Sample records for washout rate wr

  1. Effects of atrial fibrillation on myocardial washout rate of thallium-201 on myocardial perfusion single-photon emission computed tomography.

    PubMed

    Kurisu, Satoshi; Nitta, Kazuhiro; Sumimoto, Yoji; Ikenaga, Hiroki; Ishibashi, Ken; Fukuda, Yukihiro; Kihara, Yasuki

    2018-04-20

    Myocardial perfusion single-photon emission computed tomography (SPECT) with thallium (Tl)-201 is an established modality for evaluating myocardial ischemia. We assessed the effects of atrial fibrillation (AF) on the myocardial washout rate (WR) of Tl-201 on myocardial perfusion SPECT. A total of 231 patients with no evidence of myocardial ischemia were enrolled retrospectively in this study. Patients were divided into two groups on the basis of the ECG at the time of myocardial perfusion SPECT. The mean myocardial WR of Tl-201 was calculated from the stress and the redistribution Bull's eye maps. There were 34 patients with AF and 197 patients with sinus rhythm. There were no significant differences in clinical variables, except for older age and higher heart rate in patients with AF. Myocardial WR of Tl-201 was significantly lower in patients with AF than those with sinus rhythm (46±12 vs. 51±8%, P=0.03). Multivariate analysis including these factors showed that female sex (β=0.18, P=0.02), AF (β=-0.14 P=0.03), hemoglobin (β=-0.18, P<0.01), and serum creatinine (β=0.24, P<0.01) were determinants of myocardial WR of Tl-201. Our data suggest that AF is associated with reduced myocardial WR of Tl-201 on myocardial perfuison SPECT.

  2. The washout rate of (123)I-BMIPP and the evolution of left ventricular function in patients with successfully reperfused ST-segment elevation myocardial infarction: comparisons with the echocardiography.

    PubMed

    Biswas, Shankar K; Sarai, Masayoshi; Yamada, Akira; Toyama, Hiroshi; Motoyama, Sadako; Harigaya, Hiroto; Hara, Tomonori; Naruse, Hiroyuki; Hishida, Hitoshi; Ozaki, Yukio

    2010-02-01

    The evolution of the oxidative metabolism of (11)C acetate parallels the recovery of left ventricular(LV) contraction following acute myocardial infarction(AMI). This study was designed to unravel, for the first time, the impact of the global washout rate(WR) of (123)I-beta-methyl-p-iodophenylpentadecanoic acid (BMIPP) on the recovery of LV function followingAMI, as evidenced from conventional echocardiography.Twenty consecutive patients (age: 58 +/- 13 years; 16 males and 4 females) with ST-segment elevation myocardial infarction (STEMI) were enrolled and all of them underwent successful percutaneous coronary intervention (PCI). (123)I-BMIPP cardiac scintigraphy was performed at 7 +/- 3 days after admission. The WR was calculated from the polar map and the regional BMIPP defect score was calculated using a 17 segment model. Echocardiography was performed within 24 h of admission and at 3 months to record the ejection fraction (EF), the wall motion score index (WMSI), the ratio of the mitralinflow velocity to the early diastolic velocity (E/E0)and the myocardial performance index (MPI). The mean global WR of the BMIPP was 22.12 +/- 7.22%, and it was significantly correlated with the improvement of the WMSI (r = 0.61, P\\0.004). However,the relative changes of the EF, E/E0 and MPI were not correlated with the WR. The BMIPP defect score (18 +/- 10) was significantly correlated with the WMSI on admission (r = 0.74, P = 0.0002), but the defect score was not correlated with the relative changes of any of the echocardiographic parameters. We proved that the WR of the BMIPP is a promising indicator of improvement of the LV wall motion (WMSI) following ST-segment elevation myocardial infarction and successful reperfusion.

  3. Can the Contrast-Enhanced Ultrasound Washout Rate Be Used to Predict Microvascular Invasion in Hepatocellular Carcinoma?

    PubMed

    Zhu, Wei; Qing, Xiachuan; Yan, Feng; Luo, Yan; Li, Yongzhong; Zhou, Xiang

    2017-08-01

    The objective of this study was to investigate use of the washout rate of hepatocellular carcinoma on contrast-enhanced ultrasound (CEUS) for pre-operative determination of the presence of microvascular invasion. The study included 271 patients who underwent liver resection for hepatocellular carcinoma between April 2008 and December 2012, and were examined with contrast-enhanced ultrasound before surgery. Patients were followed up at 3-mo intervals for 3 y. Four washout patterns were classified according to the start time of washout: rapid, portal, delayed and slow. Rapid washout, presence of two or more tumors and tumor size ≥5 cm were identified as independent pre-operative predictors of microvascular invasion on multivariate analysis. Recurrence rates for patients with none, one, two or three predictors were 22.6%, 34.7%, 57.6% and 75.0%, respectively. In combination with tumor number and tumor size, contrast-enhanced ultrasound washout rate may have a role in identifying hepatocellular carcinoma patients with microvascular invasion. Copyright © 2017 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

  4. The metallicity dependence of WR winds

    NASA Astrophysics Data System (ADS)

    Hainich, R.; Shenar, T.; Sander, A.; Hamann, W.-R.; Todt, H.

    2017-11-01

    Wolf-Rayet (WR) stars are the most advanced stage in the evolution of the most massive stars. The strong feedback provided by these objects and their subsequent supernova (SN) explosions are decisive for a variety of astrophysical topics such as the cosmic matter cycle. Consequently, understanding the properties of WR stars and their evolution is indispensable. A crucial but still not well known quantity determining the evolution of WR stars is their mass-loss rate. Since the mass loss is predicted to increase with metallicity, the feedback provided by these objects and their spectral appearance are expected to be a function of the metal content of their host galaxy. This has severe implications for the role of massive stars in general and the exploration of low metallicity environments in particular. Hitherto, the metallicity dependence of WR star winds was not well studied. In this contribution, we review the results from our comprehensive spectral analyses of WR stars in environments of different metallicities, ranging from slightly super-solar to SMC-like metallicities. Based on these studies, we derived empirical relations for the dependence of the WN mass-loss rates on the metallicity and iron abundance, respectively.

  5. Protection of mice against fission-neutron irradiation by WR-2721 or WR-151327

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Steel, L.K.; Jacobs, A.J.; Giambarresi, L.I.

    1987-01-01

    Two phosphorothioate compounds, WR-2721 and WR-151327, were examined for their radioprotective efficacies against the effects of fission-neutron irradiation in male and female mice. Within sex groups no significant difference in lethality at 30 or 100 days postirradiation was found between WR-2721 or WR-151327 pretreatment. The dose-modification factors (DMFs) for male mice treated with either compound were 1.29 (LD50/30) and 1.24 (LD50/100), and those for drug-treated female mice were 1.21 (LD50/30) and 1.19 (LD50/100). Both WR-2721 and WR-151327 were found to be equally radioprotective when compared using DMFs as the end point. WR-151327 were found to be equally radioprotective when comparedmore » using DMFs as the end point. WR-151327 (500 mg/kg, ip) was found to be significantly more toxic to both male and female B6D2F1 mice than equimolar amounts of WR-2721. Small but significant sex differences in radioprotection were found: the DMFs for female mice pretreated with either compound were lower than those for similarly treated male mice; the incidence of mortality 31-100 days postexposure in male mice pretreated with WR-151327 was greater than for female mice. In addition, sex differences were noted in drug toxicity. Toxic death in female mice given WR-151327 (500 mg/kg, ip) is 2.6 times more probable than in males.« less

  6. Protection of mice against fission neutron irradiation by WR-2721 or WR-151327

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Steel, L.K.; Jacobs, A.J.; Giambarresi, L.I.

    1987-03-01

    Two phosphorothioate compounds, WR-2721 and WR-151327, were examined for their radioprotective efficacies against the effects of fission neutron irradiation in male and female mice. Within sex groups no significant difference in lethality at 30 or 100 days postirradiation was found between WR-2721 or WR-151327 pretreatment. The dose modification factors (DMFs) for male mice treated with either compound were 1.29 (LD50/30) and 1.24 (LD50/100), and those for drug-treated female mice were 1.21 (LD50/30) and 1.19 (LD50/100). Both WR-2721 and WR-151327 were found to be equally radioprotective when compared using DMFs as the end point. WR-151327 (500 mg/kg, ip) was found tomore » be significantly more toxic to both male and female B6D2F1 mice than equimolar amounts of WR-2721. Small but significant sex differences in radioprotection were found: the DMFs for female mice pretreated with either compound were lower than those for similarly treated male mice; the incidence of mortality 31-100 days postexposure in male mice pretreated with WR-151327 was greater than for female mice. In addition, sex differences were noted in drug toxicity. Toxic death in female mice given WR-151327 (500 mg/kg, ip) is 2.6 times more probable than in males.« less

  7. Analysis of factors that influence rates of carbon monoxide uptake, distribution, and washout from blood and extravascular tissues using a multicompartment model.

    PubMed

    Bruce, Margaret C; Bruce, Eugene N

    2006-04-01

    To better understand factors that influence carbon monoxide (CO) washout rates, we utilized a multicompartment mathematical model to predict rates of CO uptake, distribution in vascular and extravascular (muscle vs. other soft tissue) compartments, and washout over a range of exposure and washout conditions with varied subject-specific parameters. We fitted this model to experimental data from 15 human subjects, for whom subject-specific parameters were known, multiple washout carboxyhemoglobin (COHb) levels were available, and CO exposure conditions were identical, to investigate the contributions of exposure conditions and individual variability to CO washout from blood. We found that CO washout from venous blood was biphasic and that postexposure times at which COHb samples were obtained significantly influenced the calculated CO half times (P < 0.0001). The first, more rapid, phase of CO washout from the blood reflected the loss of CO to the expired air and to a slow uptake by the muscle compartment, whereas the second, slower washout phase was attributable to CO flow from the muscle compartment back to the blood and removal from blood via the expired air. When the model was used to predict the effects of varying exposure conditions for these subjects, the CO exposure duration, concentration, peak COHb levels, and subject-specific parameters each influenced washout half times. Blood volume divided by ventilation correlated better with half-time predictions than did cardiac output, muscle mass, or ventilation, but it explained only approximately 50% of half-time variability. Thus exposure conditions, COHb sampling times, and individual parameters should be considered when estimating CO washout rates for poisoning victims.

  8. Radioprotective Thiolamines WR-1065 and WR-33278 Selectively Denature Nonhistone Nuclear Proteins

    NASA Technical Reports Server (NTRS)

    Booth, Valerie K.; Roberts, Jeanette C.; Warters, Raymond L.; Wilmore, Britta H.; Lepock, James R.

    2000-01-01

    Differential scanning calorimetry was used to study the interactions of nuclei isolated from Chinese hamster V79 cells with the radioprotector WR-1065, other thiol compounds, and polyamines. Differential scanning calorimetry monitors denaturation of macromolecules and resolves the major nuclear components (e.g. constrained and relaxed DNA, nucleosome core, and nuclear matrix) of intact nuclei on the basis of thermal stability. WR-1065 treatment (0.5-10 mM) of isolated nuclei led to the irreversible denaturation of nuclear proteins, a fraction of which are nuclear matrix proteins. Denaturation of 50% of the total nonhistone nuclear protein content of isolated nuclei occurred after exposure to 4.7 mM WR-1065 for 20 min at 23 C. In addition, a 22% increase in the insoluble protein content of nuclei isolated from V79 cells that had been treated with 4 mM WR-1065 for 30 min at 37 C was observed, indicating that WR-1065-induced protein denaturation occurs not only in isolated nuclei but also in the nuclei of intact cells. From the extent of the increase in insoluble protein in the nucleus, protein denaturation by WR-1065 is expected to contribute to drug toxicity at concentrations greater than approximately 4 mM. WR-33278, the disulfide form of WR1065, was approximately twice as effective as the free thiol at denaturing nuclear proteins. The proposed mechanism for nucleoprotein denaturation is through direct interactions with protein cysteine groups with the formation of destabilizing protein-WR-1065 disulfides. In comparison to its effect on nuclear proteins in isolated nuclei, WR-1065 had only a very small effect on non-nuclear proteins of whole cells, isolated nuclear matrix, or the thiol-rich Ca (2+) ATPase of sarcoplasmic reticulum, indicating that WR-1065 can effectively denature protein only inside an intact nucleus, probably due to the increased concentration of the positively charged drug in the vicinity of DNA.

  9. 99 mTc-MIBI washout as a complementary factor in the evaluation of idiopathic dilated cardiomyopathy (IDCM) using myocardial perfusion imaging.

    PubMed

    Shiroodi, Mohammad Kazem; Shafiei, Babak; Baharfard, Nastaran; Gheidari, Mohammad Esmail; Nazari, Babak; Pirayesh, Elaheh; Kiasat, Ali; Hoseinzadeh, Samaneh; Hashemi, Abolghassem; Akbarzadeh, Mohammad Ali; Javadi, Hamid; Nabipour, Iraj; Assadi, Majid

    2012-01-01

    Rapid technetium-99 m methoxyisobutylisonitrile (99 mTc-MIBI) washout has been shown to occur in impaired myocardia. This study is based on the hypothesis that scintigraphy can be applied to calculate the myocardial 99 mTc-MIBI washout rate (WR) to diagnose and evaluate heart failure severity and other left ventricular functional parameters specifically in idiopathic dilated cardiomyopathy (IDCM) patients. Patients with IDCMP (n = 17; 52.65 ± 11.47 years) and normal subjects (n = 6; 49.67 ± 10.15 years) were intravenously administered 99 mTc-hexakis-2-methoxyisobutylisonitrile (99 mTc-MIBI). Next, early and delayed planar data were acquired (at 3.5-h intervals), and electrocardiogram (ECG)-gated myocardial perfusion single photon emission computed tomography (SPECT) was performed. The 99 mTc-MIBI WR was calculated using early and delayed planar images. Left ventricular functional parameters were also analyzed using quantitative gated SPECT (QGS) data. In target group, myocardial WRs (29.13 ± 6.68%) were significantly higher than those of control subjects (14.17 ± 3.31%; P < 0.001). The 99 mTc-MIBI WR increased with the increasing severity of the NYHA functional class (23.16 ± 1.72% for class I, 30.25 ± 0.95% for class II, 32.60 ± 6.73% for class III, and 37.50 ± 7.77% for class IV; P = 0.02). The WR was positively correlated with the end-diastolic volume (EDV) index (r (2) = 0.216; β = 0.464; P = 0.02 [ml/m(2)], the end-systolic volume (ESV) index (r (2) = 0.234; β = 0.484; P = 0.01 [ml/m(2)]), the summed motion score (SMS) (r (2) = 0.544; β = 0.738; P = 0.00), and the summed thickening score (STS) (r (2) = 0.656; β = 0.810; P = 0.00); it was negatively correlated with the left ventricular ejection fraction (LVEF) (r (2) = 0.679; β = -0.824; P = 0.00). It can be concluded that 99 mTc-MIBI scintigraphy might be a valuable molecular imaging tool for the diagnosis and evaluation of myocardial damage or dysfunction severity.

  10. The CHARA Array resolves the long-period Wolf-Rayet binaries WR 137 and WR 138

    NASA Astrophysics Data System (ADS)

    Richardson, Noel D.; Shenar, Tomer; Roy-Loubier, Olivier; Schaefer, Gail; Moffat, Anthony F. J.; St-Louis, Nicole; Gies, Douglas R.; Farrington, Chris; Hill, Grant M.; Williams, Peredur M.; Gordon, Kathryn; Pablo, Herbert; Ramiaramanantsoa, Tahina

    2016-10-01

    We report on interferometric observations with the CHARA Array of two classical Wolf-Rayet (WR) stars in suspected binary systems, namely WR 137 and WR 138. In both cases, we resolve the component stars to be separated by a few milliarcseconds. The data were collected in the H band, and provide a measure of the fractional flux for both stars in each system. We find that the WR star is the dominant H-band light source in both systems (fWR,137 = 0.59 ± 0.04; fWR,138 = 0.67 ± 0.01), which is confirmed through both comparisons with estimated fundamental parameters for WR stars and O dwarfs, as well as through spectral modelling of each system. Our spectral modelling also provides fundamental parameters for the stars and winds in these systems. The results on WR 138 provide evidence that it is a binary system which may have gone through a previous mass-transfer episode to create the WR star. The separation and position of the stars in the WR 137 system together with previous results from the IOTA interferometer provides evidence that the binary is seen nearly edge-on. The possible edge-on orbit of WR 137 aligns well with the dust production site imaged by the Hubble Space Telescope during a previous periastron passage, showing that the dust production may be concentrated in the orbital plane.

  11. Investigation of nonlinear motion simulator washout schemes

    NASA Technical Reports Server (NTRS)

    Riedel, S. A.; Hofmann, L. G.

    1978-01-01

    An overview is presented of some of the promising washout schemes which have been devised. The four schemes presented fall into two basic configurations; crossfeed and crossproduct. Various nonlinear modifications further differentiate the four schemes. One nonlinear scheme is discussed in detail. This washout scheme takes advantage of subliminal motions to speed up simulator cab centering. It exploits so-called perceptual indifference thresholds to center the simulator cab at a faster rate whenever the input to the simulator is below the perceptual indifference level. The effect is to reduce the angular and translational simulation motion by comparison with that for the linear washout case. Finally, the conclusions and implications for further research in the area of nonlinear washout filters are presented.

  12. Washout and non-washout solutions of a system describing microbial fermentation process under the influence of growth inhibitions and maximal concentration of yeast cells.

    PubMed

    Kasbawati; Gunawan, Agus Yodi; Sidarto, Kuntjoro Adjie

    2017-07-01

    An unstructured model for the growth of yeast cell on glucose due to growth inhibitions by substrate, products, and cell density is discussed. The proposed model describes the dynamical behavior of fermentation system that shows multiple steady states for a certain regime of operating parameters such as inlet glucose and dilution rate. Two types of steady state solutions are found, namely washout and non-washout solutions. Furthermore, different numerical impositions to the two parameters put in evidence three results regarding non-washout solution: a unique locally stable non-washout solution, a unique locally stable non-washout solution towards which other nearby solutions exhibit damped oscillations, and multiple non-washout solutions where one is locally stable while the other is unstable. It is also found an optimal inlet glucose which produces the highest cell and ethanol concentration. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. WR 120bb and WR 120bc: a pair of WN9h stars with possibly interacting circumstellar shells

    NASA Astrophysics Data System (ADS)

    Burgemeister, S.; Gvaramadze, V. V.; Stringfellow, G. S.; Kniazev, A. Y.; Todt, H.; Hamann, W.-R.

    2013-03-01

    Two optically obscured Wolf-Rayet (WR) stars have been recently discovered by means of their infrared (IR) circumstellar shells, which show signatures of interaction with each other. Following the systematics of the WR star catalogues, these stars obtain the names WR 120bb and WR 120bc. In this paper, we present and analyse new near-IR, J-, H- and K-band spectra using the Potsdam Wolf-Rayet model atmosphere code. For that purpose, the atomic data base of the code has been extended in order to include all significant lines in the near-IR bands. The spectra of both stars are classified as WN9h. As their spectra are very similar the parameters that we obtained by the spectral analyses hardly differ. Despite their late spectral subtype, we found relatively high stellar temperatures of 63 kK. The wind composition is dominated by helium, while hydrogen is depleted to 25 per cent by mass. Because of their location in the Scutum-Centaurus Arm, WR 120bb and WR 120bc appear highly reddened, A_{K_s} ≈ 2 mag. We adopt a common distance of 5.8 kpc to both stars, which complies with the typical absolute K-band magnitude for the WN9h subtype of -6.5 mag, is consistent with their observed extinction based on comparison with other massive stars in the region, and allows for the possibility that their shells are interacting with each other. This leads to luminosities of log ({textit {L}/L}_{odot }) = 5.66 and 5.54 for WR 120bb and WR 120bc, with large uncertainties due to the adopted distance. The values of the luminosities of WR 120bb and WR 120bc imply that the immediate precursors of both stars were red supergiants (RSG). This implies in turn that the circumstellar shells associated with WR 120bb and WR 120bc were formed by interaction between the WR wind and the dense material shed during the preceding RSG phase.

  14. Properties of selected S-nitrosothiols compared to nitrosylated WR-1065.

    PubMed

    Whiteside, William Michael; Sears, Devin N; Young, Paul R; Rubin, David B

    2002-05-01

    WR-1065 ([N-mercaptoethyl]-1-3-diaminopropane), the active form of the aminothiol drug Ethyol/Amifostine, protects against toxicity caused by radiation, chemotherapy and endotoxin. Because WR-1065 and other thiols readily bind nitric oxide (NO), injurious conditions or therapies that induce the production or mobilization of NO could alter the effects of WR-1065. S-Nitrosothiols were prepared from various thiols by a standard method to compare properties and stability. Heteromolecular quantum correlation 2D nuclear magnetic resonance was used to characterize nitrosylated glutathione (GSH) and WR-1065; both S- and N-nitrosothiols were observed, depending on the experimental conditions. Three categories of S-nitrosothiol stability were observed: (1) highly stable, with t(1/2) > 8 h, N-acetyl-L-cysteine nitrosothiol (t(1/2) 15 h) > GSH nitrosothiol (t(1/2) 8 h); (2) intermediate stability, t(1/2) approximately 2 h, cysteamine nitrosothiol and WR-1065 nitrosothiol; and (3) low stability, t(1/2) < 1 h, cysteine nitrosothiol and Captopril nitrosothiol. Similar relative rates were observed for Hg(+2)-induced denitrosylation: WR-1065 reacted faster than GSH nitrosothiol, while GSH nitrosothiol reacted faster than N-acetyl-L-cysteine nitrosothiol. Mostly mediated by mixed-NPSH disulfide formation, the activity of the redox-sensitive cysteine protease, cathepsin H, was inhibited by the S-nitrosothiols, with WR-1065 nitrosothiol > cysteine nitrosothiol > N-acetyl-L-cysteine nitrosothiol and GSH nitrosothiol. These observations indicate that, relative to other nitrosylated non-protein thiols, the S-nitrosothiol of WR-1065 is an unstable non-protein S-nitrosothiols with a high reactive potential in the modification of protein thiols.

  15. A comparison of washout filters using a human dynamic orientation model. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Riedel, S. A.

    1977-01-01

    The Ormsby model of human dynamic orientation, a discrete time computer program, was used to provide a vestibular explanation for observed differences between two washout schemes. These washout schemes, a linear washout and a nonlinear washout, were subjectively evaluated. It was found that the linear washout presented false rate cues, causing pilots to rate the simulation fidelity of the linear scheme much lower than the nonlinear scheme. By inputting these motion histories into the Ormsby model, it was shown that the linear filter causes discontinuities in the pilot's perceived angular velocity, resulting in the sensation of an anomalous rate cue. This phenomenon does not occur with the use of the nonlinear filter.

  16. Krogh-cylinder and infinite-domain models for washout of an inert diffusible solute from tissue.

    PubMed

    Secomb, Timothy W

    2015-01-01

    Models based on the Krogh-cylinder concept are developed to analyze the washout from tissue by blood flow of an inert diffusible solute that permeates blood vessel walls. During the late phase of washout, the outflowing solute concentration decays exponentially with time. This washout decay rate is predicted for a range of conditions. A single capillary is assumed to lie on the axis of a cylindrical tissue region. In the classic "Krogh-cylinder" approach, a no-flux boundary condition is applied on the outside of the cylinder. An alternative "infinite-domain" approach is proposed that allows for solute exchange across the boundary, but with zero net exchange. Both models are analyzed, using finite-element and analytical methods. The washout decay rate depends on blood flow rate, tissue diffusivity and vessel permeability of solute, and assumed boundary conditions. At low blood flow rates, the washout rate can exceed the value for a single well-mixed compartment. The infinite-domain approach predicts slower washout decay rates than the Krogh-cylinder approach. The infinite-domain approach overcomes a significant limitation of the Krogh-cylinder approach, while retaining its simplicity. It provides a basis for developing methods to deduce transport properties of inert solutes from observations of washout decay rates. © 2014 John Wiley & Sons Ltd.

  17. Sodium 22+ washout from cultured rat cells

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kino, M.; Nakamura, A.; Hopp, L.

    1986-10-01

    The washout of Na/sup +/ isotopes from tissues and cells is quite complex and not well defined. To further gain insight into this process, we have studied /sup 22/Na/sup +/ washout from cultured Wistar rat skin fibroblasts and vascular smooth muscle cells (VSMCs). In these preparations, /sup 22/Na/sup +/ washout is described by a general three-exponential function. The exponential factor of the fastest component (k1) and the initial exchange rate constant (kie) of cultured fibroblasts decrease in magnitude in response to incubation in K+-deficient medium or in the presence of ouabain and increase in magnitude when the cells are incubatedmore » in a Ca++-deficient medium. As the magnitude of the kie declines (in the presence of ouabain) to the level of the exponential factor of the middle component (k2), /sup 22/Na/sup +/ washout is adequately described by a two-exponential function. When the kie is further diminished (in the presence of both ouabain and phloretin) to the range of the exponential factor of the slowest component (k3), the washout of /sup 22/Na/sup +/ is apparently monoexponential. Calculations of the cellular Na/sup +/ concentrations, based on the /sup 22/Na/sup +/ activity in the cells at the initiation of the washout experiments, and the medium specific activity agree with atomic absorption spectrometry measurements of the cellular concentration of this ion. Thus, all three components of /sup 22/Na/sup +/ washout from cultured rat cells are of cellular origin. Using the exponential parameters, compartmental analyses of two models (in parallel and in series) with three cellular Na/sup +/ pools were performed. The results indicate that, independent of the model chosen, the relative size of the largest Na+ pool is 92-93% in fibroblasts and approximately 96% in VSMCs. This pool is most likely to represent the cytosol.« less

  18. X-rays from the colliding wind binary WR 146

    NASA Astrophysics Data System (ADS)

    Zhekov, Svetozar A.

    2017-12-01

    The X-ray emission from the massive Wolf-Rayet binary (WR 146 ) is analysed in the framework of the colliding stellar wind (CSW) picture. The theoretical CSW model spectra match well the shape of the observed X-ray spectrum of WR 146, but they overestimate considerably the observed X-ray flux (emission measure). This is valid in the case of both complete temperature equalization and partial electron heating at the shock fronts (different electron and ion temperatures), but there are indications for a better correspondence between model predictions and observations for the latter. To reconcile the model predictions and observations, the mass-loss rate of WR 146 must be reduced by a factor of 8-10 compared to the currently accepted value for this object (the latter already takes clumping into account). No excess X-ray absorption is derived from the CSW modelling.

  19. WR 148 and the not so compact companion

    NASA Astrophysics Data System (ADS)

    Munoz, Melissa; Moffat, Anthony J.; Hill, Grant M.; Shenar, Tomer; Richardson, Noel D.; Pablo, Herbert; St-Louis, Nicole; Ramiaramanantsoa, Tahina

    2017-11-01

    The objective is to determine the nature of the unseen companion of the single-lined spectroscopic binary, WR 148 (= WN7h+?). The absence of companion lines supports a compact companion (cc) scenario. The lack of hard X-rays favours a non-compact companion scenario. Is WR 148 a commonplace WR+OB binary or a rare WR+cc binary?

  20. Association of Deep Brain Stimulation Washout Effects With Parkinson Disease Duration

    PubMed Central

    Cooper, Scott E.; McIntyre, Cameron C.; Fernandez, Hubert H.; Vitek, Jerrold L.

    2016-01-01

    Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves symptoms of Parkinson disease (PD), including bradykinesia. When stimulation ceases abruptly, bradykinesia returns gradually. The duration of the gradual, slow washout varies across patients, and although the origin of this variability is unclear, it is hypothesized to be related to 1 or more clinical characteristics of patients. Objective To determine if a correlation exists between clinical characteristics of patients with Parkinson disease (age, age at disease onset, disease severity, disease duration, medication dose, or time since surgery) and the washout rate for bradykinesia when STN DBS is discontinued. Design Serial quantitative assessments of bradykinesia were performed during a defined period following cessation of STN DBS. Setting Academic research. Patients Twenty-four patients with Parkinson disease who underwent STN DBS were enrolled in the study. Patients were assessed while off medication (medication had been discontinued 10½ to 16½ hours before testing), and stimulator settings were unchanged for a mean (median) of 20 (14) months. Main Outcome Measures We measured bradykinesia in the dominant hand by assessing finger tapping (item 23 on the Unified Parkinson Disease Rating Scale), which was quantified using an angular velocity transducer strapped on the index finger. Finger tapping was assessed every 2 minutes for 20 seconds at a time. This was performed during a 20-minute period with DBS on (baseline period), during a 50-minute period following discontinuation of STN DBS for the dominant hand, and again during a 20-minute period after turning on the device. Results When STN DBS was turned off, an initial fast but partial loss of benefit was observed, which was followed by a further slow washout of the residual therapeutic effect. The half-life of the slow washout phase varied significantly across patients, and this variation was strongly related to disease

  1. CO2 Washout Testing of NASA Space Suits

    NASA Technical Reports Server (NTRS)

    Norcross, Jason

    2012-01-01

    During the presentation "CO2 Washout Testing of NASA Spacesuits," Jason Norcross discussed the results of recent carbon dioxide CO2 washout testing of NASA spacesuits including the Rear Entry I-suit (REI), Enhanced Mobility Advanced Crew Escape Suit (EM-ACES), and possibly the ACES and Z-1 EVA prototype. When a spacesuit is used during ground testing, adequate CO2 washout must be provided for the suited subject. Symptoms of acute CO2 exposure depend on the partial pressure of CO2 (ppCO2) available to enter the lungs during respiration. The primary factors during ground-based testing that influence the ppCO2 level in the oronasal area include the metabolic rate of the subject and air flow through the suit. These tests were done to characterize inspired oronasal ppCO2 for a range of workloads and flow rates for which ground testing is nominally performed. During this presentation, Norcross provided descriptions of the spacesuits, test hardware, methodology, and results, as well as implications for future ground testing and verification of flight requirements.

  2. Washout policies in long-term indwelling urinary catheterisation in adults.

    PubMed

    Shepherd, Ashley J; Mackay, William G; Hagen, Suzanne

    2017-03-06

    four were parallel-group randomised controlled trials (RCTs). Of these, two trials were added for this update (one parallel-group RCT with 40 participants and one cross-over RCT with 67 participants). Analyses of three cross-over trials yielded suboptimal results because they were based on between-group differences rather than individual participants' differences for sequential interventions. Two parallel-group trials had limited clinical value: one combined results for suprapubic and urethral catheters and the other provided data for only four participants. Only one trial was free of significant methodological limitations, but there were difficulties with recruitment and maintaining participants in this study.The included studies reported data on six of the nine primary and secondary outcome measures. None of the trials addressed: number of catheters used, washout acceptability measures (including patient satisfaction, patient discomfort, pain and ease of use), or health status/measures of psychological health; very limited data were collected for health economic outcomes. Trials assessed only three of the eight intervention comparisons identified. Two trials reported in more than one comparison group.Four trials compared washout (either saline or acidic solution) with no washout. We are uncertain if washout solutions (saline or acidic), compared to no washout solutions, has an important effect on the rate of symptomatic urinary tract infection or length of time each catheter was in situ because the results are imprecise.Four trials compared different types of washout solution; saline versus acidic solutions (2 trials); saline versus acidic solution versus antibiotic solution (1 trial); saline versus antimicrobial solution (1 trial). We are uncertain if type of washout solution has an important effect on the rate of symptomatic urinary tract infection or length of time each catheter was in situ because the results are imprecise.One trial compared different

  3. Location of WR stars in NGC 6744

    NASA Astrophysics Data System (ADS)

    Bibby, Joanne; Crowther, Paul; Sandford, Emily

    2013-06-01

    Following our recent survey of Wolf-Rayet (WR) stars in NGC 6744 we present a preliminary investigation into the location of these stars. Using high spatial resolution Hα images we find that the majority of WR stars are associated with nebular emission, albeit faint in many cases. We can use this HII association to constrain the lifetime and mass of the WR star since HII regions are such short-lived.

  4. Do catheter washouts extend patency time in long-term indwelling urethral catheters? A randomized controlled trial of acidic washout solution, normal saline washout, or standard care.

    PubMed

    Moore, Katherine N; Hunter, Kathleen F; McGinnis, Rosemary; Bacsu, Chasta; Fader, Mandy; Gray, Mikel; Getliffe, Kathy; Chobanuk, Janice; Puttagunta, Lakshmi; Voaklander, Donald C

    2009-01-01

    Blockage of long-term indwelling catheters with mineral deposit is an ongoing management issue, but evidence on optimal management is lacking. Our purpose was to examine whether catheter washouts prevent or reduce catheter blockage. A multisite randomized controlled trial. Adults with long-term indwelling catheters that required changing every 3 weeks or less, living in the community, and requiring supportive or continuing care were recruited. Participants were randomly assigned to 1 of 3 groups: control (usual care, no washout), saline washout, or commercially available acidic washout solution (Contisol Maelor Pharmaceuticals Ltd, Wrexham, UK). At baseline visit, the catheter was changed and participants were followed weekly for 8 weeks, with checks for catheter patency and urine pH. Participants randomized to saline or commercial solution had a weekly washout with the appropriate solution. Endpoints were 8 weeks (completion data), 3 or more catheter changes in the 8-week period, or symptomatic urinary tract infection (UTI) requiring antibiotics. The study hypothesis was that catheter life would be extended by 25% in the commercial solution group. It was not possible to blind participants or research nurses to washout versus no intervention, but participants in the saline and washout solution groups were blinded to solution type. One hundred twelve potential participants were screened; 73 were enrolled, randomized, and included in the final analysis. Of these, 53 completed the full 8 weeks of data collection; 16 terminated early because of 3 catheter changes or self-reported 'UTI'. Other reasons for termination were hematuria, latex sensitivity, deceased/severe illness, or personal choice. Analysis of variance was used to analyze mean differences on demographic variables and mean number of weeks in study. Kaplan-Meier survival curve analysis showed no statistical difference between the groups in time to first catheter change. At this time, the evidence is

  5. Creating an enabling environment for WR&R implementation.

    PubMed

    Stathatou, P-M; Kampragou, E; Grigoropoulou, H; Assimacopoulos, D; Karavitis, C; Gironás, J

    2017-09-01

    Reclaimed water is receiving growing attention worldwide as an effective solution for alleviating the growing water scarcity in many areas. Despite the various benefits associated with reclaimed water, water recycling and reuse (WR&R) practices are not widely applied around the world. This is mostly due to complex and inadequate local legal and institutional frameworks and socio-economic structures, which pose barriers to wider WR&R implementation. An integrated approach is therefore needed while planning the implementation of WR&R schemes, considering all the potential barriers, and aiming to develop favourable conditions for enhancing reclaimed water use. This paper proposes a comprehensive methodology supporting the development of an enabling environment for WR&R implementation. The political, economic, social, technical, legal and institutional factors that may influence positively (drivers) or negatively (barriers) WR&R implementation in the regional water systems are identified, through the mapping of local stakeholder perceptions. The identified barriers are further analysed, following a Cross-Impact/System analysis, to recognize the most significant barriers inhibiting system transition, and to prioritize the enabling instruments and arrangements that are needed to boost WR&R implementation. The proposed methodology was applied in the Copiapó River Basin in Chile, which faces severe water scarcity. Through the analysis, it was observed that barriers outweigh drivers for the implementation of WR&R schemes in the Copiapó River Basin, while the key barriers which could be useful for policy formulation towards an enabling environment in the area concern the unclear legal framework regarding the ownership of treated wastewater, the lack of environmental policies focusing on pollution control, the limited integration of reclaimed water use in current land use and development policies, the limited public awareness on WR&R, and the limited availability of

  6. Washout policies in long-term indwelling urinary catheterisation in adults.

    PubMed

    Hagen, Suzanne; Sinclair, Lesley; Cross, Stephen

    2010-03-17

    analyses reported for the two cross-over trials were inappropriate as they were based on differences between groups rather than differences within individuals receiving sequential interventions. Two parallel-group trials had limited value: one combined results for suprapubic and urethral catheters and one had data on only four participants. Only one trial was free of significant methodological limitations, but its sample size was small.Three trials compared no washout with one or more washout solution (saline or acidic solutions) and authors tended to conclude no difference in clinical outcomes between washout and no washout. In the one trial which had data of sufficient quality to allow interpretation, no difference was detected between washout and no washout groups in the rate of symptomatic urinary tract infection or time to first catheter change. Three trials compared different types of solution: saline versus acidic solutions (two trials); saline versus acidic solution versus antibiotic solution (one trial). Authors tended to report no difference between different washout solutions but the data were too few to support their conclusions. The one trial which warranted consideration concluded no difference between saline and an acidic solution in terms of symptomatic urinary tract infections or time to first catheter change. The data from five trials comparing differing washout policies were sparse and trials were generally of poor quality or poorly reported. The evidence was too scanty to conclude whether or not washouts were beneficial. In the first instance we require further rigorous, high quality trials with adequate power to detect any benefit from washout being performed as opposed to none. Then trials comparing different washout solutions, washout volumes, frequencies/timings and routes of administration are needed.

  7. Space Suit CO2 Washout During Intravehicular Activity

    NASA Technical Reports Server (NTRS)

    Augustine, Phillip M.; Navarro, Moses; Conger, Bruce; Sargusingh, Miriam M.

    2010-01-01

    Space suit carbon dioxide (CO2) washout refers to the removal of CO2 gas from the oral-nasal area of a suited astronaut's (or crewmember's) helmet using the suit's ventilation system. Inadequate washout of gases can result in diminished mental/cognitive abilities as well as headaches and light headedness. In addition to general discomfort, these ailments can impair an astronaut s ability to perform mission-critical tasks ranging from flying the space vehicle to performing lunar extravehicular activities (EVAs). During design development for NASA s Constellation Program (CxP), conflicting requirements arose between the volume of air flow that the new Orion manned space vehicle is allocated to provide to the suited crewmember and the amount of air required to achieve CO2 washout in a space suit. Historically, space suits receive 6.0 actual cubic feet per minute (acfm) of air flow, which has adequately washed out CO2 for EVAs. For CxP, the Orion vehicle will provide 4.5 acfm of air flow to the suit. A group of subject matter experts (SM Es) among the EVA Systems community came to an early consensus that 4.5 acfm may be acceptable for low metabolic rate activities. However, this value appears very risky for high metabolic rates, hence the need for further analysis and testing. An analysis was performed to validate the 4.5 acfm value and to determine if adequate CO2 washout can be achieved with the new suit helmet design concepts. The analysis included computational fluid dynamic (CFD) modeling cases, which modeled the air flow and breathing characteristics of a human wearing suit helmets. Helmet testing was performed at the National Institute of Occupational Safety and Health (NIOSH) in Pittsburgh, Pennsylvania, to provide a gross-level validation of the CFD models. Although there was not a direct data correlation between the helmet testing and the CFD modeling, the testing data showed trends that are very similar to the CFD modeling. Overall, the analysis yielded

  8. Randomized, Double-Blinded, Phase 2 Trial of WR 279,396 (Paromomycin and Gentamicin) for Cutaneous Leishmaniasis in Panama

    PubMed Central

    Sosa, Néstor; Capitán, Zeuz; Nieto, Javier; Nieto, Melissa; Calzada, José; Paz, Hector; Spadafora, Carmenza; Kreishman-Deitrick, Mara; Kopydlowski, Karen; Ullman, Diane; McCarthy, William F.; Ransom, Janet; Berman, Jonathan; Scott, Charles; Grogl, Max

    2013-01-01

    In this randomized, double-blinded Phase 2 trial, 30 patients with Leishmania panamensis cutaneous leishmaniasis were randomly allocated (1:1) to receive once daily topical treatment with WR 279,396 (15% paromomycin + 0.5% gentamicin) or Paromomycin Alone (15% paromomycin) for 20 days. The index lesion cure rate after 6 months follow-up was 13 of 15 (87%) for WR 279,396 and 9 of 15 (60%) for Paromomycin Alone (P = 0.099). When all treated lesions were included, the final cure rate for WR 279,398-treated patients was again 87%, but the final cure rate for Paromomycin Alone-treated patients was 8 of 15 (53.3%; P = 0.046). Both creams were well tolerated with mild application site reactions being the most frequent adverse event. The increased final cure rate in the WR 279,396 group in this small Phase 2 study suggests that the combination product may provide greater clinical benefit than paromomycin monotherapy against L. panamensis cutaneous leishmaniasis. PMID:23857024

  9. X-ray observations of the colliding wind binary WR 25

    NASA Astrophysics Data System (ADS)

    Arora, Bharti; Pandey, Jeewan Chandra

    2018-04-01

    Using the archival data obtained from Chandra and Suzaku spanning over '8 years, we present an analysis of a WN6h+O4f Wolf-Rayet binary, WR 25. The X-ray light curves folded over a period of '208 d in the 0.3 - 10.0 keV energy band showed phase-locked variability where the count rates were found to be maximum near the periastron passage. The X-ray spectra of WR 25 were well explained by a two-temperature plasma model with temperatures of 0.64 ± 0.01 and 2.96 ± 0.05 keV and are consistent with previous results. The orbital phase dependent local hydrogen column density was found to be maximum just after the periastron passage, when the WN type star is in front of the O star. The hard (2.0 - 10.0 keV) X-ray luminosity was linearly dependent on the inverse of binary separation which confirms that WR 25 is a colliding wind binary.

  10. Family ties of WR to LBV nebulae yielding clues for stellar evolution

    NASA Astrophysics Data System (ADS)

    Weis, K.

    Luminous Blue Variables (LBVs) are stars is a transitional phase massive stars may enter while evolving from main-sequence to Wolf-Rayet stars. The to LBVs intrinsic photometric variability is based on the modulation of the stellar spectrum. Within a few years the spectrum shifts from OB to AF type and back. During their cool phase LBVs are close to the Humphreys-Davidson (equivalent to Eddington/Omega-Gamma) limit. LBVs have a rather high mass loss rate, with stellar winds that are fast in the hot and slower in the cool phase of an LBV. These alternating wind velocities lead to the formation of LBV nebulae by wind-wind interactions. A nebula can also be formed in a spontaneous giant eruption in which larger amounts of mass are ejected. LBV nebulae are generally small (< 5 pc) mainly gaseous circumstellar nebulae, with a rather large fraction of LBV nebulae being bipolar. After the LBV phase the star will turn into a Wolf-Rayet star, but note that not all WR stars need to have passed the LBV phase. Some follow from the RSG and the most massive directly from the MS phase. In general WRs have a large mass loss and really fast stellar winds. The WR wind may interact with winds of earlier phases (MS, RSG) to form WR nebulae. As for WR with LBV progenitors the scenario might be different, here no older wind is present but an LBV nebula! The nature of WR nebulae are therefore manifold and in particular the connection (or family ties) of WR to LBV nebulae is important to understand the transition between these two phases, the evolution of massive stars, their winds, wind-wind and wind-nebula interactions. Looking at the similarities and differences of LBV and WR nebula, figuring what is a genuine LBV and WR nebula are the basic question addressed in the analysis presented here.

  11. The Orbit and Distance of WR140

    NASA Astrophysics Data System (ADS)

    Dougherty, S. M.; Trenton, V.; Beasley, A. J.

    2011-01-01

    A campaign of 35 epochs of milli-arcsecond resolution VLBA observations of the archetype colliding-wind WR+O star binary system WR 140 show the wind-collision region (WCR) as a bow-shaped arc of emission that rotates as the highly eccentric orbit progresses. The observations comprise 21 epochs from the 1993-2001 orbit, discussed by Dougherty et al. (2005), and 14 epochs from the 2001-2009 orbit, and span orbital phase 0.43 to 0.95. Assuming the WCR is symmetric about the line-of-centres of the two stars and ``points'' at the WR star, this rotation shows the O star moving from SE to E of the WR star between these orbital phases. Using IR interferometry observations from IOTA that resolve both stellar components at phase 0.297 in conjunction with orbital parameters derived from radial velocity variations, the VLBA observations constrain the inclination of the orbit plane as 120°±4°, the longitude of the ascending node as 352°±2°, and the orbit semi-major axis as 9.0±0.1 mas. This leads to a distance estimate to WR 140 of 1.81±0.08 kpc. Further refinements of the orbit and distance await more IR interferometric observations of the stellar components directly.

  12. The massive star O+WR binary γ Velorum

    NASA Astrophysics Data System (ADS)

    De Marco, O.; Willis, A. J.; Colley, S. R.

    2001-12-01

    The γ Vel O+WR binary system is known to have colliding winds from its X-ray properties. Here we use the stellar parameters of the two stars in the system, derived from the non-LTE models of De Marco & Schmutz (2000) and De Marco et al. (2000), to aid in the interpretation of the optical line variability in terms of the geometry and distribution of the gas around the two stars. We find that the rich dataset (high signal-to-noise ratio, high resolution optical spectra finely sampling the orbital period) allows a very accurate determination of the opening angle of the wake formed as the WR wind impacts the O star. This can lead to understanding whether radiative breaking (of the WR wind gas by the O star radiation field) is efficient in this system. From the location of the emission line forming regions within the WR wind (from the non-LTE models), and the variability patterns of those lines, it is possible to construct a detailed map of the WR wind. Work financed by the Asimov Fellowship program of the Americam Museum of Natural History.

  13. Pinwheel Nebula around WR 98a.

    PubMed

    Monnier; Tuthill; Danchi

    1999-11-10

    We present the first near-infrared images of the dusty Wolf-Rayet star WR 98a. Aperture-masking interferometry has been utilized to recover images at the diffraction limit of the Keck I telescope, less, similar50 mas at 2.2 µm. Multiepoch observations spanning about 1 yr have resolved the dust shell into a "pinwheel" nebula, the second example of a new class of dust shell first discovered around WR 104 by Tuthill, Monnier, & Danchi. Interpreting the collimated dust outflow in terms of an interacting winds model, the binary orbital parameters and apparent wind speed are derived: a period of 565+/-50 days, a viewing angle of 35&j0;+/-6 degrees from the pole, and a wind speed of 99+/-23 mas yr-1. This period is consistent with a possible approximately 588 day periodicity in the infrared light curve, linking the photometric variation to the binary orbit. Important implications for binary stellar evolution are discussed by identifying WR 104 and WR 98a as members of a class of massive, short-period binaries whose orbits were circularized during a previous red supergiant phase. The current component separation in each system is similar to the diameter of a red supergiant, which indicates that the supergiant phase was likely terminated by Roche lobe overflow, leading to the present Wolf-Rayet stage.

  14. Spectroscopy of the archetype colliding-wind binary WR 140 during the 2009 January periastron passage

    NASA Astrophysics Data System (ADS)

    Fahed, R.; Moffat, A. F. J.; Zorec, J.; Eversberg, T.; Chené, A. N.; Alves, F.; Arnold, W.; Bergmann, T.; Corcoran, M. F.; Correia Viegas, N. G.; Dougherty, S. M.; Fernando, A.; Frémat, Y.; Gouveia Carreira, L. F.; Hunger, T.; Knapen, J. H.; Leadbeater, R.; Marques Dias, F.; Martayan, C.; Morel, T.; Pittard, J. M.; Pollock, A. M. T.; Rauw, G.; Reinecke, N.; Ribeiro, J.; Romeo, N.; Sánchez-Gallego, J. R.; Dos Santos, E. M.; Schanne, L.; Stahl, O.; Stober, Ba.; Stober, Be.; Vollmann, K.; Williams, P. M.

    2011-11-01

    We present the results from the spectroscopic monitoring of WR 140 (WC7pd + O5.5fc) during its latest periastron passage in 2009 January. The observational campaign consisted of a constructive collaboration between amateur and professional astronomers. It took place at six locations, including Teide Observatory, Observatoire de Haute Provence, Dominion Astrophysical Observatory and Observatoire du Mont Mégantic. WR 140 is known as the archetype of colliding-wind binaries and it has a relatively long period (?8 yr) and high eccentricity (?0.9). We provide updated values for the orbital parameters, new estimates for the WR and O star masses and new constraints on the mass-loss rates and colliding-wind geometry.

  15. Single-Dose Absorption and Pharmacokinetics of WR 6026. Phase 1

    DTIC Science & Technology

    1988-08-01

    glucose, uric acid , calcium, phosphate, 8 total protein, albumin, direct and total bilirubin, aspartate aminotransferase (AST), alanine aminotransferase...Fitted Equation 42 Table 8 Elimination Rate Constant and Plasma Half-Life of WK 6026 43 Table 9 Pharmacokinetic Data for Individual Subjects 44 Table 10...failure rate of antimony compounds and the toxicity of other effective drugs, there is a clear need for development of alternative drugs. WR 6026 (8-(6

  16. Effect of hydration on nitrogen washout in human subjects

    NASA Technical Reports Server (NTRS)

    Waligora, J.; Horrigan, D. J., Jr.; Conkin, J.

    1983-01-01

    Five subjects were tested to assess the influence of drinking hypotonic water (distilled water) on whole body tissue nitrogen washout. During the test, the subjects breathed aviators' oxygen for three hours. Each subject performed two baseline nitrogen washouts in a two-week period. The third washout, in the third week, was done under a transient hydrated condition. This was accomplished by having the subjects drink 1.5 liters of hypotonic water 30 minutes before the washout. Five-minute plots of tissue nitrogen removal from the three separate washouts were analyzed to ascertain if the hydration technique had any effect. Our results clearly indicate that the hydration technique did not alter the tissue nitrogen washout characteristics to any degree over three hours. An increase in tissue nitrogen washout under a transient hydrated condition using hypotonic fluid was not demonstrated to be the mechanism responsible for the reported benefit of this technique in preventing Type I altitude decompression pain in man.

  17. Suzaku monitoring of the Wolf-Rayet binary WR140

    NASA Astrophysics Data System (ADS)

    Sugawara, Yasuharu; Maeda, Yoshitomo; Tsuboi, Yohko; Hamaguchi, Kenji

    2010-07-01

    We report the preliminary results of the Suzaku observations of the W-R binary WR 140 (WC7+O5I). We executed the observations at four different epochs around periastron passage in Jan. 2009 to understand the W-R stellar wind as well as the wind-wind collision shocks. The total exposure was 210 ksec. We detected hard X-ray excess in the HXD band (>10 keV) for the first time from a W-R binary. Another notable discovery was a soft component which is not absorbed even by the dense wind. The spectra can be fitted by three different components; one is for the stationary cool component with kT ~0.1 keV, one for a dominant high temperature component with kT ~3 keV, and one for the hardest power-low component with Γ~2. The column density at periastron is 30 times higher than that at pre-periastron, which can be explained as self-absorption by the W-R wind. The emission measure of the dominant, high temperature component is not inversely proportional to the distance between the two stars.

  18. Colliding winds in five WR+O systems of the Southern hemisphere

    NASA Astrophysics Data System (ADS)

    Fahed, R.; Moffat, A. F. J.

    2012-08-01

    We present the results of an optical spectroscopic follow-up of five WR+O systems of the Southern hemisphere that have not been studied so far for wind-wind collisions: WR 12 (WN8h), WR 21 (WN5o+O7V), WR 30 (WC6+O7.5V), WR 31 (WN4o+O8) and WR 47 (WN6o+O5). Observations were made over an entire contiguous month using the Garrison spectrograph attached to the 0.6-m Helen Sawyer Hogg telescope at Complejo Astronomico El Leoncito. We obtain improved orbital elements for these five systems and provide an estimation of the orbital inclination and shock-cone opening angle for four of them by analysing excess emission profiles with the geometrical model of Lührs. We argue that line variability in one of the stars (WR 12) might be dominated by some dynamic instabilities in the shocked plasma, making the model inappropriate in this case. A sixth star, WR 69 (WC9d+OB), was observed in the programme based on its published photometric period of 2.293 ± 0.005 d. While we found a probable spectroscopic period of 2.15 ± 0.04 d compatible with that of Marchenko et al. (1998), the period is unlikely related to orbital effects, rather to (relatively fast) rotation of the WC9d component of a much longer binary system.

  19. Large-scale Periodic Variability of the Wind of the Wolf-Rayet Star WR 1 (HD 4004)

    NASA Astrophysics Data System (ADS)

    Chené, A.-N.; St-Louis, N.

    2010-06-01

    We present the results of an intensive photometric and spectroscopic monitoring campaign of the WN4 Wolf-Rayet (WR) star WR 1 = HD 4004. Our broadband V photometry covering a timespan of 91 days shows variability with a period of P = 16.9+0.6 -0.3 days. The same period is also found in our spectral data. The light curve is non-sinusoidal with hints of a gradual change in its shape as a function of time. The photometric variations nevertheless remain coherent over several cycles and we estimate that the coherence timescale of the light curve is of the order of 60 days. The spectroscopy shows large-scale line-profile variability which can be interpreted as excess emission peaks moving from one side of the profile to the other on a timescale of several days. Although we cannot unequivocally exclude the unlikely possibility that WR 1 is a binary, we propose that the nature of the variability we have found strongly suggests that it is due to the presence in the wind of the WR star of large-scale structures, most likely corotating interaction regions (CIRs), which are predicted to arise in inherently unstable radiatively driven winds when they are perturbed at their base. We also suggest that variability observed in WR 6, WR 134, and WR 137 is of the same nature. Finally, assuming that the period of CIRs is related to the rotational period, we estimate the rotation rate of the four stars for which sufficient monitoring has been carried out, i.e., v rot = 6.5, 40, 70, and 275 km s-1 for WR 1, WR 6, WR 134, and WR 137, respectively. Based on observations obtained at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council of Canada, the Institut National des Sciences de l'Univers of the Centre National de Recherche Scientifique of France, and the University of Hawaii. Also based on observations obtained at the Observatoire du Mont Mégantic with is operated by the Centre de Recherche en Astrophysique du Québec and the Observatoire de

  20. Successful Application of Low Loss, Over-Moded WR-187 Waveguide to the ASDE-3 Radar

    DOT National Transportation Integrated Search

    1982-04-01

    Overmoded WR-187 waveguide has been incorporated into the short-range ASDE-3 system to provide a low-loss interconnection between the antenna and the transmitter/receiver. WR-62 to WR-187 transitions and WR-187 mode suppressors were developed specifi...

  1. X-Ray modeling of η Carinae & WR 140 from SPH simulations

    NASA Astrophysics Data System (ADS)

    Russell, Christopher M. P.; Corcoran, Michael F.; Okazaki, Atsuo T.; Madura, Thomas I.; Owocki, Stanley P.

    2011-07-01

    The colliding wind binary (CWB) systems η Carinae and WR140 provide unique laboratories for X-ray astrophysics. Their wind-wind collisions produce hard X-rays that have been monitored extensively by several X-ray telescopes, including RXTE. To interpret these RXTE X-ray light curves, we apply 3D hydrodynamic simulations of the wind-wind collision using smoothed particle hydrodynamics (SPH). We find adiabatic simulations that account for the absorption of X-rays from an assumed point source of X-ray emission at the apex of the wind-collision shock cone can closely match the RXTE light curves of both η Car and WR140. This point-source model can also explain the early recovery of η Car's X-ray light curve from the 2009.0 minimum by a factor of 2-4 reduction in the mass loss rate of η Car. Our more recent models account for the extended emission and absorption along the full wind-wind interaction shock front. For WR140, the computed X-ray light curves again match the RXTE observations quite well. But for η Car, a hot, post-periastron bubble leads to an emission level that does not match the extended X-ray minimum observed by RXTE. Initial results from incorporating radiative cooling and radiative forces via an anti-gravity approach into the SPH code are also discussed.

  2. WR and LBV stars

    NASA Astrophysics Data System (ADS)

    Kochiashvili, Nino; Beradze, Sophie; Kochiashvili, Ia; Natsvlishvili, Rezo; Vardosanidze, Manana

    Evolutionary scenarios of massive stars were revised in recent decades, after finding "unusual", blue progenitor of SN 1987A and after detecting the more massive stars than the accepted 120 M ⊙ maximum limit of stellar masses. A very important relation exists between WR and LBV stars. They represent the earlier, pre-SN evolutionary states of massive stars. WR and LBV stars and "classic" evolutionary scheme of the relation between the different type massive stars are discussed in this article. There also exist the newest evolutionary scenarios for low metallicity massive stars, which give us a different picture of their post main-sequence evolution. There is a rather good tradition of observations and investigations of massive stars at Abastumani Astrophysical Observatory. The authors discuss the new findings on the fate of P Cygni, the LBV star. These results on the reddening of the star and about its next possible outburst in the near future were obtained on the basis of UBV long-term electrophotometric observations of P Cygni by Eugene Kharadze and Nino Magalashvili. The observations were held in 1951-1983 at Abastumani Observatory using 33-cm and 48-cm reflectors.

  3. Washout policies in long-term indwelling urinary catheterization in adults: a short version cochrane review.

    PubMed

    Sinclair, Lesley; Hagen, Suzanne; Cross, Stephen

    2011-09-01

    protocol were addressed in these trials. Some trials addressed more than one comparison (e.g., washout vs. no washout and one type of washout solution vs. another). The analyses reported for the two cross-over trials were inappropriate as they were based on differences between groups rather than differences within individuals receiving sequential interventions. Two parallel-group trials had limited value: one combined results for suprapubic and urethral catheters and one had data on only four participants. Only one trial was free of significant methodological limitations, but its sample size was small. Three trials compared no washout with one or more washout solution (saline or acidic solutions) and authors tended to conclude no difference in clinical outcomes between washout and no washout. In the one trial which had data of sufficient quality to allow interpretation, no difference was detected between washout and no washout groups in the rate of symptomatic urinary tract infection or time to first catheter change. Three trials compared different types of solution: saline versus acidic solutions (two trials); saline versus acidic solution versus antibiotic solution (one trial). Authors tended to report no difference between different washout solutions but the data were too few to support their conclusions. The one trial which warranted consideration concluded no difference between saline and an acidic solution in terms of symptomatic urinary tract infections or time to first catheter change. The data from five trials comparing differing washout policies were sparse and trials were generally of poor quality or poorly reported. The evidence was too scant to conclude whether or not washouts were beneficial. Further rigorous, high quality trials with adequate power to detect any benefit from washout rather than no washout being performed are required in the first instance. After that, trials comparing different washout solutions, washout volumes, frequencies/timings, and

  4. Differential antimutagenicity of WR-1065 added after irradiation in L5178Y cell lines

    NASA Technical Reports Server (NTRS)

    Evans, H. H.; Horng, M. F.; Ricanati, M.; McCoy, E. C.

    1999-01-01

    The purpose of this study was to determine the antimutagenicity of WR-1065 added after irradiation of cells of cell lines differing in their ability to rejoin radiation-induced DNA double-strand breaks (DSBs). The postirradiation antimutagenicity of WR-1065 at the thymidine kinase locus was demonstrated for L5178Y (LY)-S1 cells that are deficient in repair of DNA DSBs. Less postirradiation antimutagenicity of WR-1065 was observed in LY-R16 and LY-SR1 cells, which are relatively efficient in DSB repair. Postirradiation treatment with WR-1065 had only a small stimulatory effect on DSB rejoining. A 3-h incubation of irradiated LY cells with WR-1065 caused slight changes in the distribution of cells in the phases of the cell cycle that differed between LY-S1 and LY-SR1 cells. Both LY-S1 and LY-SR1 cells were protected against the cytotoxic and mutagenic effects of radiation when WR-1065 was present 30 min before and during the irradiation. We conclude that the differential postirradiation effects of WR-1065 in the LY-S1 and LY-SR1 cells are not caused by differences in cellular uptake of the radioprotector or in its radical scavenging activity. Possible mechanisms for the postirradiation antimutagenicity of WR-1065 are discussed.

  5. Are the O stars in WR+O binaries exceptionally rapid rotators?

    NASA Astrophysics Data System (ADS)

    Reeve, Dominic; Howarth, Ian D.

    2018-05-01

    We examine claims of strong gravity-darkening effects in the O-star components of WR+O binaries. We generate synthetic spectra for a wide range of parameters, and show that the line-width results are consistent with extensive measurements of O stars that are either single or are members of `normal' binaries. By contrast, the WR+O results are at the extremes of, or outside, the distributions of both models and other observations. Remeasurement of the WR+O spectra shows that they can be reconciled with other results by judicious choice of pseudo-continuum normalization. With this interpretation, the supersynchronous rotation previously noted for the O-star components in the WR+O binaries with the longest orbital periods appears to be unexceptional. Our investigation is therefore consistent with the aphorism that if the title of a paper ends with a question mark, the answer is probably `no'.

  6. Application of nonlinear adaptive motion washout to transport ground-handling simulation

    NASA Technical Reports Server (NTRS)

    Parrish, R. V.; Martin, D. J., Jr.

    1983-01-01

    The application of a nonlinear coordinated adaptive motion washout to the transport ground-handling environment is documented. Additions to both the aircraft math model and the motion washout system are discussed. The additions to the simulated-aircraft math model provided improved modeling fidelity for braking and reverse-thrust application, and the additions to the motion-base washout system allowed transition from the desired flight parameters to the less restrictive ground parameters of the washout.

  7. X-ray Modeling of η Carinae & WR140 from SPH Simulations

    NASA Astrophysics Data System (ADS)

    Russell, Christopher M. P.; Corcoran, Michael F.; Okazaki, Atsuo T.; Madura, Thomas I.; Owocki, Stanley P.

    2011-01-01

    The colliding wind binary (CWB) systems η Carinae and WR140 provide unique laboratories for X-ray astrophysics. Their wind-wind collisions produce hard X-rays that have been monitored extensively by several X-ray telescopes, including RXTE. To interpret these RXTE X-ray light curves, we model the wind-wind collision using 3D smoothed particle hydrodynamics (SPH) simulations. Adiabatic simulations that account for the emission and absorption of X-rays from an assumed point source at the apex of the wind-collision shock cone by the distorted winds can closely match the observed 2-10keV RXTE light curves of both η Car and WR140. This point-source model can also explain the early recovery of η Car's X-ray light curve from the 2009.0 minimum by a factor of 2-4 reduction in the mass loss rate of η Car. Our more recent models relax the point-source approximation and account for the spatially extended emission along the wind-wind interaction shock front. For WR140, the computed X-ray light curve again matches the RXTE observations quite well. But for η Car, a hot, post-periastron bubble leads to an emission level that does not match the extended X-ray minimum observed by RXTE. Initial results from incorporating radiative cooling and radiatively-driven wind acceleration via a new anti-gravity approach into the SPH code are also discussed.

  8. A NEAR-INFRARED SURVEY OF THE INNER GALACTIC PLANE FOR WOLF-RAYET STARS. II. GOING FAINTER: 71 MORE NEW W-R STARS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shara, Michael M.; Faherty, Jacqueline K.; Zurek, David

    We are continuing a J, K and narrowband imaging survey of 300 deg{sup 2} of the plane of the Galaxy, searching for new Wolf-Rayet (W-R) stars. Our survey spans 150 Degree-Sign in Galactic longitude and reaches 1 Degree-Sign above and below the Galactic plane. The survey has a useful limiting magnitude of K = 15 over most of the observed Galactic plane, and K = 14 (due to severe crowding) within a few degrees of the Galactic center. Thousands of emission-line candidates have been detected. In spectrographic follow-ups of 146 relatively bright W-R star candidates, we have re-examined 11 previouslymore » known WC and WN stars and discovered 71 new W-R stars, 17 of type WN and 54 of type WC. Our latest image analysis pipeline now picks out W-R stars with a 57% success rate. Star subtype assignments have been confirmed with the K-band spectra and distances approximated using the method of spectroscopic parallax. Some of the new W-R stars are among the most distant known in our Galaxy. The distribution of these new W-R stars is beginning to trace the locations of massive stars along the distant spiral arms of the Milky Way.« less

  9. Radioprotection of mouse skin vasculature and the RIF-1 fibrosarcoma by WR-2721

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Penhaligon, M.

    1984-09-01

    The degree of radioprotection obtained with WR-2721 is critically dependent upon the oxygen tension of the tissue concerned. It was therefore considered of interest to examine the response of vascular tissue, which would be supposedly well oxygenated, to treatment with WR-2721 plus X rays. The response of this tissue is of interest because of its role in late radiation damage. In addition, for therapeutic gain an agent must protect normal tissue without concomitant tumor protection. However, data on tumor radioprotection have been conflicting and therefore the effect of WR-2721 on an experimental tumor was also tested. Vascular damage was assessedmore » using the fact that tumors grow more slowly in irradiated beds (Tumor Bed Effect). WR-2721 injected 30 minutes before 5 to 30 Gy X rays protected skin stroma by a factor of 1.6. However, WR-2721 given 10 to 60 minutes before 20 Gy X rays to the RIF-1 tumor had either no effect or was protective, according to the method of immobilizing the mice during irradiation.« less

  10. Wash-out in N{sub 2}-dominated leptogenesis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hahn-Woernle, F., E-mail: fhahnwo@mppmu.mpg.de

    2010-08-01

    We study the wash-out of a cosmological baryon asymmetry produced via leptogenesis by subsequent interactions. Therefore we focus on a scenario in which a lepton asymmetry is established in the out-of-equilibrium decays of the next-to-lightest right-handed neutrino. We apply the full classical Boltzmann equations without the assumption of kinetic equilibrium and including all quantum statistical factors to calculate the wash-out of the lepton asymmetry by interactions of the lightest right-handed state. We include scattering processes with top quarks in our analysis. This is of particular interest since the wash-out is enhanced by scatterings and the use of mode equations withmore » quantum statistical distribution functions. In this way we provide a restriction on the parameter space for this scenario.« less

  11. Compartmental analysis of washout effect in rat brain: in-beam OpenPET measurement using a 11C beam

    NASA Astrophysics Data System (ADS)

    Hirano, Yoshiyuki; Kinouchi, Shoko; Ikoma, Yoko; Yoshida, Eiji; Wakizaka, Hidekazu; Ito, Hiroshi; Yamaya, Taiga

    2013-12-01

    In-beam positron emission tomography (PET) is expected to enable visualization of a dose verification using positron emitters (β+ decay). For accurate dose verification, correction of the washout of the positron emitters should be made. In addition, the quantitative washout rate has a potential usefulness as a diagnostic index, but modeling for this has not been studied yet. In this paper, therefore, we applied compartment analyses to in-beam PET data acquired by our small OpenPET prototype, which has a physically opened field-of-view (FOV) between two detector rings. A rat brain was located at the FOV and was irradiated by a 11C beam. Time activity curves of the irradiated field were measured immediately after the irradiations, and the washout rate was obtained based on two models: the two-washout model (medium decay, k2m; slow decay, k2s) developed in a study of rabbit irradiation; and the two-compartment model used in nuclear medicine, where efflux from tissue to blood (k2), influx (k3) and efflux (k4) from the first to second compartments in tissue were evaluated. The observed k2m and k2s were 0.34 and 0.005 min-1, respectively, which was consistent with the rabbit study. Also k2m was close to the washout rate in cerebral blood flow (CBF) measurements by dynamic PET with 15O-water, while, k2, k3, and k4 were 0.16, 0.15 and 0.007 min-1. Our present work suggested the dynamics of 11C might be relevant to CBF or permeability of a molecule containing 11C atoms might be regulated by a transporter because the k2 was relatively low compared with a simple diffusion tracer.

  12. WR 148: identifying the companion of an extreme runaway massive binary*

    NASA Astrophysics Data System (ADS)

    Munoz, Melissa; Moffat, Anthony F. J.; Hill, Grant M.; Shenar, Tomer; Richardson, Noel D.; Pablo, Herbert; St-Louis, Nicole; Ramiaramanantsoa, Tahina

    2017-05-01

    WR 148 (HD 197406) is an extreme runaway system considered to be a potential candidate for a short-period (4.3173 d) rare WR + compact object binary. Provided with new high-resolution, high signal-to-noise spectra from the Keck observatory, we determine the orbital parameters for both the primary WR and the secondary, yielding respective projected orbital velocity amplitudes of 88.1 ± 3.8 km s-1 and 79.2 ± 3.1 km s-1 and implying a mass ratio of 1.1 ± 0.1. We then apply the shift-and-add technique to disentangle the spectra and obtain spectra compatible with a WN7ha and an O4-6 star. Considering an orbital inclination of ˜67°, derived from previous polarimetry observations, the system's total mass would be a mere 2-3M_{⊙}, an unprecedented result for a putative massive binary system. However, a system comprising a 37 M_{⊙} secondary (typical mass of an O5V star) and a 33 M_{⊙} primary (given the mass ratio) would infer an inclination of ˜18°. We therefore reconsider the previous methods of deriving the orbital inclination based on time-dependent polarimetry and photometry. While the polarimetric results are inconclusive requiring better data, the photometric results favour low inclinations. Finally, we compute WR 148's space velocity and retrace the runaway's trajectory back to the Galactic plane (GP). With an ejection velocity of 198 ± 27 km s-1 and a travel time of 4.7 ± 0.8 Myr to reach its current location, WR 148 was most likely ejected via dynamical interactions in a young cluster.

  13. Characterization of Carbon Dioxide Washout Measurement Techniques in the Mark-III Space Suit

    NASA Technical Reports Server (NTRS)

    Meginnis, Ian M.; Norcross, Jason; Bekdash, Omar; Ploutz-Snyder, Robert

    2016-01-01

    A space suit must provide adequate carbon dioxide (CO2) washout inside the helmet to prevent symptoms of hypercapnia. In the past, an oronasal mask has been used to measure the inspired air of suited subjects to determine a space suit's CO2 washout capability. While sufficient for super-ambient pressure testing of space suits, the oronasal mask fails to meet several human factors and operational criterion needed for future sub-ambient pressure testing (e.g. compatibility with a Valsalva device). This paper describes the evaluation of a nasal cannula as a device for measuring inspired air within a space suit. Eight test subjects were tasked with walking on a treadmill or operating an arm ergometer to achieve target metabolic rates of 1000, 2000, and 3000 British thermal units per hour (BTU/hr), at flow rates of 2, 4, and 6 actual cubic feet per minute (ACFM). Each test configuration was conducted twice, with subjects instructed to breathe either through their nose only, or however they felt comfortable. Test data shows that the nasal cannula provides more statistically consistent data across test subjects than the oronasal mask used in previous tests. The data also shows that inhaling/exhaling through only the nose provides a lower sample variance than a normal breathing style. Nose-only breathing reports better CO2 washout due to several possible reasons, including a decreased respiratory rate, an increased tidal volume, and because nose-only breathing directs all of the exhaled CO2 down and away from the oronasal region. The test subjects in this study provided feedback that the nasal cannula is comfortable and can be used with the Valsalva device.

  14. Burr Hole Washout versus Craniotomy for Chronic Subdural Hematoma: Patient Outcome and Cost Analysis

    PubMed Central

    Regan, Jacqueline M.; Worley, Emmagene; Shelburne, Christopher; Pullarkat, Ranjit; Watson, Joseph C.

    2015-01-01

    Chronic subdural hematomas (CSDH), which are frequently encountered in neurosurgical practice, are, in the majority of cases, ideally treated with surgical drainage. Despite this common practice, there is still controversy surrounding the best surgical procedure. With lack of clear evidence of a superior technique, surgeons are free to base the decision on other factors that are not related to patient care. A retrospective chart review of 119 patients requiring surgical drainage of CSDH was conducted at a large tertiary care center over a three-year period. Of the cases reviewed, 58 patients underwent craniotomy, while 61 patients underwent burr hole washout. The study focused on re-operation rates, mortality, and morbidity, as measured by Glasgow coma scores (GCS), discharge Rankin disability scores, and discharge disposition. Secondary endpoints included length of stay and cost of procedure. Burr hole washout was superior to craniotomy with respect to patient outcome, length of stay and recurrence rates. In both study groups, patients required additional surgical procedures (6.6% of burr hole patients and 24.1% of craniotomy patients) (P = 0.0156). Of the patients treated with craniotomy, 51.7% were discharged home, whereas 65.6% of the burr hole patients were discharged home. Patients who underwent burr hole washout spent a mean of 78.8 minutes in the operating suite while the patients undergoing craniotomy spent 129.4 minutes (P < 0.001). The difference in mean cost per patient, based solely on operating time, was $2,828 (P < 0.001). This does not include the further cost due to additional procedures and hospital stay. The mean length of stay after surgical intervention was 3 days longer for the craniotomy group (P = 0.0465). Based on this retrospective study, burr hole washout is superior for both patients’ clinical and financial outcome; however, prospective long-term multicenter clinical studies are required to verify these findings. PMID:25611468

  15. Burr hole washout versus craniotomy for chronic subdural hematoma: patient outcome and cost analysis.

    PubMed

    Regan, Jacqueline M; Worley, Emmagene; Shelburne, Christopher; Pullarkat, Ranjit; Watson, Joseph C

    2015-01-01

    Chronic subdural hematomas (CSDH), which are frequently encountered in neurosurgical practice, are, in the majority of cases, ideally treated with surgical drainage. Despite this common practice, there is still controversy surrounding the best surgical procedure. With lack of clear evidence of a superior technique, surgeons are free to base the decision on other factors that are not related to patient care. A retrospective chart review of 119 patients requiring surgical drainage of CSDH was conducted at a large tertiary care center over a three-year period. Of the cases reviewed, 58 patients underwent craniotomy, while 61 patients underwent burr hole washout. The study focused on re-operation rates, mortality, and morbidity, as measured by Glasgow coma scores (GCS), discharge Rankin disability scores, and discharge disposition. Secondary endpoints included length of stay and cost of procedure. Burr hole washout was superior to craniotomy with respect to patient outcome, length of stay and recurrence rates. In both study groups, patients required additional surgical procedures (6.6% of burr hole patients and 24.1% of craniotomy patients) (P = 0.0156). Of the patients treated with craniotomy, 51.7% were discharged home, whereas 65.6% of the burr hole patients were discharged home. Patients who underwent burr hole washout spent a mean of 78.8 minutes in the operating suite while the patients undergoing craniotomy spent 129.4 minutes (P < 0.001). The difference in mean cost per patient, based solely on operating time, was $2,828 (P < 0.001). This does not include the further cost due to additional procedures and hospital stay. The mean length of stay after surgical intervention was 3 days longer for the craniotomy group (P = 0.0465). Based on this retrospective study, burr hole washout is superior for both patients' clinical and financial outcome; however, prospective long-term multicenter clinical studies are required to verify these findings.

  16. The variable X-ray spectrum of the Wolf-Rayet binary WR140 with Suzaku

    NASA Astrophysics Data System (ADS)

    Sugawara, Yasuharu; Maeda, Yoshitomo; Tsuboi, Yohko; Hamaguchi, Kenji; Corcoran, Michael; Pollock, Andy; Moffat, Anthony; Williams, Peredur; Dougherty, Sean; Pittard, Julian

    2011-01-01

    We report the preliminary results of the Suzaku observations of the W-R binary WR 140 (WC7+O5I). We executed the observations at four different epochs around periastron passage in Jan. 2009 to understand the W-R stellar wind as well as the wind-wind collision shocks. The total exposure was 210 ks. We detected hard X-ray excess in the HXD band (> 10 keV) for the first time from a W-R binary. Another notable discovery was a soft component which is less absorbed even by the dense wind. The spectra can be fitted by three different components; one is for the cool component with kT=0.1--0.6 keV, one for a dominant high-temperature component with kT ˜3 keV, and one for the hardest power-law component with the photon index of ˜2. As periastron approached, the column density of the high-temperature component increased, which can be explained as self-absorption by the W-R wind. The emission measure of the dominant, high-temperature component is not inversely proportional to the distance between the two stars.

  17. A Chandra grating observation of the dusty Wolf-Rayet star WR 48a

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhekov, Svetozar A.; Gagné, Marc; Skinner, Stephen L., E-mail: szhekov@space.bas.bg, E-mail: mgagne@wcupa.edu, E-mail: stephen.skinner@colorado.edu

    We present results of a Chandra High-Energy Transmission Grating (HETG) observation of the carbon-rich Wolf-Rayet (WR) star WR 48a. These are the first high-resolution spectra of this object in X-ray. Blueshifted centroids of the spectral lines of ∼ – 360 km s{sup –1} and line widths of 1000-1500 km s{sup –1} (FWHM) were deduced from the analysis of the line profiles of strong emission lines. The forbidden line of Si XIII is strong and not suppressed, indicating that the rarified 10-30 MK plasma forms far from strong sources of far-ultraviolet emission, most likely in a wind collision zone. Global spectralmore » modeling showed that the X-ray spectrum of WR 48a suffered higher absorption in the 2012 October Chandra observation compared with a previous 2008 January XMM-Newton observation. The emission measure of the hot plasma in WR 48a decreased by a factor ∼3 over the same period of time. The most likely physical picture that emerges from the analysis of the available X-ray data is that of colliding stellar winds in a wide binary system with an elliptical orbit. We propose that the unseen secondary star in the system is another WR star or perhaps a luminous blue variable.« less

  18. Risk Assessment for the Explosive Washout Lagoons (Site 4), Umatilla Depot Activity Hermiston, Oregon

    DTIC Science & Technology

    1992-03-01

    Activity .............................. 2 2-2 Explosive Washout Lagoons (Site 4) and Washout Plant Area ............................... 2-3 3-1 Site 4...ponds for liquid wastes from bomb-washing operations in the washout plant . The measured dimensions of the flat bottoms of the two lagoons are 30 by 80...explosives washout plant system was drained, flushed, and cleaned approximately once each week from the mid-1950s until 1965. The lagoons received all of the

  19. Kinetics of Uptake and Washout of Lidocaine in Rat Sciatic Nerve In Vitro

    PubMed Central

    Leeson, Stanley; Strichartz, Gary

    2012-01-01

    Background The potency and efficacy of local anesthetics injected clinically for peripheral nerve block depends strongly on the rate of neural drug uptake. However, since diffusion into surrounding tissues and removal by the vascular system are major factors in the overall distribution of lidocaine in vivo, true kinetics of drug/neural tissue interactions must be studied in the absence of those confounding factors. Methods Uptake: Ensheathed or desheathed isolated rat sciatic nerves were exposed to [14C]-lidocaine for 0-180min and then removed and the lidocaine content of nerve and sheath analyzed. Washout: Isolated nerves were soaked in [14C]-lidocaine for 60min and then placed in lidocaine-free solution for 0-30min, with samples removed at different times to assess the drug content. Experimental variables included the effects of the ensheathing epineurium, lidocaine concentration, pH, presence of CO2-bicarbonate, and incubation duration. Results The equilibrium uptake of lidocaine increased with incubation time, concentration and the fraction of molecules in the non-ionized form. The uptake rate was unaffected by drug concentration, but was about halved by the presence of the epineurial sheath, with the washout rate slowed less. Slight alkalinization, from pH 6.8 to pH 7.4, by bicarbonate-CO2 buffer or a non-bicarbonate buffer, enhanced the neural uptake, and to the same degree. The washout of lidocaine was faster after shorter incubations at high concentrations than when equal amounts of lidocaine were taken up after long incubations at low lidocaine concentrations. Conclusion Lidocaine enters a nerve by a process other than free diffusion, through an epineurial sheath that is a slight obstacle. Given the rapid entry in vitro compared to the much smaller and transient content measured in vivo, it seems highly unlikely that lidocaine equilibrates with the nerve during a peripheral blockade. PMID:23400993

  20. Maintaining Adequate Carbon Dioxide Washout for an Advanced Extravehicular Mobility Unit

    NASA Technical Reports Server (NTRS)

    Chullen, Cinda; Navarro, Moses; Conger, Bruce; Korona, Adam; McMillin, Summer; Norcross, Jason; Swickrath, Mike

    2013-01-01

    Over the past several years, NASA has realized tremendous progress in technology development that is aimed at the production of an Advanced Extravehicular Mobility Unit (AEMU). Of the many functions provided by the spacesuit and portable life support subsystem within the AEMU, delivering breathing gas to the astronaut along with removing the carbon dioxide (CO2) remains one of the most important environmental functions that the AEMU can control. Carbon dioxide washout is the capability of the ventilation flow in the spacesuit helmet to provide low concentrations of CO2 to the crew member to meet breathing requirements. CO2 washout performance is a critical parameter needed to ensure proper and sufficient designs in a spacesuit and in vehicle applications such as sleep stations and hygiene compartments. Human testing to fully evaluate and validate CO2 washout performance is necessary but also expensive due to the levied safety requirements. Moreover, correlation of math models becomes challenging because of human variability and movement. To supplement human CO2 washout testing, a breathing capability will be integrated into a suited manikin test apparatus to provide a safe, lower cost, stable, easily modeled alternative to human testing. Additionally, this configuration provides NASA Johnson Space Center (JSC) the capability to evaluate CO2 washout under off-nominal conditions that would otherwise be unsafe for human testing or difficult due to fatigue of a test subject. Testing has been under way in-house at JSC and analysis has been initiated to evaluate whether the technology provides sufficient performance in ensuring that the CO2 is removed sufficiently and the ventilation flow is adequate for maintaining CO2 washout in the AEMU spacesuit helmet of the crew member during an extravehicular activity. This paper will review recent CO2 washout testing and analysis activities, testing planned in-house with a spacesuit simulator, and the associated analytical work

  1. Antimutagenicity of WR-1065 in L5178Y cells exposed to accelerated (56)Fe ions

    NASA Technical Reports Server (NTRS)

    Evans, H. H.; Evans, T. E.; Horng, M. F.

    2002-01-01

    The ability of the aminothiol WR-1065 [N-(2-mercaptoethyl)-1,3-diaminopropane] to protect L5178Y (LY) cells against the cytotoxic and mutagenic effects of exposure to accelerated (56)Fe ions (1.08 GeV/nucleon) was determined. It was found that while WR-1065 reduced the mutagenicity in both cell lines when it was present during the irradiation, the addition of WR-1065 after the exposure had no effect on the mutagenicity of the radiation in either cell line. No marked protection against the cytotoxic effects of exposure to (56)Fe ions was provided by WR-1065 when added either during or after irradiation in either cell line. We reported previously that WR-1065 protected the LY-S1 and LY-SR1 cell lines against both the cytotoxicity and mutagenicity of X radiation when present during exposure, but that its protection when administered after exposure was limited to the mutagenic effects in the radiation-hypersensitive cell line, LY-S1. The results indicate that the mechanisms involved differ in the protection against cytotoxic compared to mutagenic effects and in the protection against damage caused by accelerated (56)Fe ions compared to X radiation.

  2. [Research on the eventual cross-reactivity of anti-Wr(a) with various viral, bacterial and mycotic antigenes (author's transl)].

    PubMed

    Garelli, S; Valbonesi, M; Picerno, G; Vazzana, A

    1978-09-01

    Among the sera of 1011 blood donors, they have been collected 34 anti-Wr(a) antibodies. By IgG antiglobulin test, the titer was 1/8 or more in 21 sera. After absorption on viral, bacterial and mycotic antigens, the sera were still reactive with Wr(a) + red blood cells. These results show that no tested antigen is cross-reactive with Wr(a) antigen. However, the AA. suggest that the research of a widley diffused antigen, cross-reactive with Wr(a) + red blood cells, is a valuable approach to the problem of IgG anti-Wr(a) antibodies in normal, never transfused blood donors.

  3. Determination of the cytoprotective agent WR-2721 (Amifostine, Ethyol) and its metabolites in human blood using monobromobimane fluorescent labeling and high-performance liquid chromatography.

    PubMed

    Souid, A K; Newton, G L; Dubowy, R L; Fahey, R C; Bernstein, M L

    1998-01-01

    WR-2721 [S-2-(3-aminopropylamino)ethylphosphorothioic acid] is a chemoprotective agent that is currently in pediatric clinical trials. It is a prodrug that is dephosphorylated by alkaline phosphatase to the active free thiol form, WR-1065 [S-2-(3-aminopropylamino)ethanethiol]. It is likely that adequate and sustained cellular levels of the drug are necessary for optimum cytoprotection. To date, a method to measure both plasma and cellular levels of WR-2721 and its metabolites in clinical samples has not been available. In the study reported here the monobromobimane (mBBr) fluorescent labeling method was used to measure these levels when drug was added in vitro to blood samples from normal volunteers. In addition, we present pharmacokinetic data from a pediatric patient receiving WR-2721 (825 mg/m2 x 2). The results can be summarized as follows: (1) WR-2721 was detected in the patient's plasma with a half-life of about 10 min; (2) the WR-1065 concentration in the blood cellular fraction was similar to that of plasma; (3) both WR-1065 and WR-SS-low molecular weight (WR-SS-LMW) metabolites disappeared from plasma and the cellular fraction by 3.6 h after WR-2721 infusion; (4) a large proportion of WR-1065 was oxidized in plasma to WR-SS protein and WR-SS-LMW; (5) a large proportion of WR-1065 in the cellular fraction was oxidized to WR-SS-protein; (6) the WR-SS-LMW concentration in the cellular fraction was low; and (7) saturation of plasma and cellular protein binding sites was possible. The pharmacokinetic data that were generated with this technique could guide clinical trials using WR-2721.

  4. Physical properties of the WR stars in Westerlund 1

    NASA Astrophysics Data System (ADS)

    Rosslowe, C. K.; Crowther, P. A.; Clark, J. S.; Negueruela, I.

    The Westerlund 1 (Wd1) cluster hosts a rich and varied collection of massive stars. Its dynamical youth and the absence of ongoing star formation indicate a coeval population. As such, the simultaneous presence of both late-type supergiants and Wolf-Rayet stars has defied explanation in the context of single-star evolution. Observational evidence points to a high binary fraction, hence this stellar population offers a robust test for stellar models accounting for both single-star and binary evolution. We present an optical to near-IR (VLT & NTT) spectroscopic analysis of 22 WR stars in Wd 1, delivering physical properties for the WR stars. We discuss how these differ from the Galactic field population, and how they may be reconciled with the predictions of single and binary evolutionary models.

  5. A New Surgical Device for Anterograde Intraoperative Rectal Washout.

    PubMed

    Rondelli, Fabio; Santinelli, Roberto; Stella, Paolo; Bugiantella, Walter; Ceccarelli, Graziano; Balzarotti, Ruben Carlo; De Rosa, Michele; Avenia, Nicola

    2018-06-01

    Colorectal cancer is the fourth most diffuse cause of death in the world and local recurrence is associated with a reduced long-term life expectancy, with a reduced quality of life. Rectal washout at the anastomosis site leads to a statistically significant reduction of local recurrences. We developed the idea of a new laparoscopic stapler with an integrated washout system that could decontaminate the rectal stump before resection, without the need to enlarge the standard surgical incision or even to distort the incision site, closing the rectal stump just below the inferior part of the cancer, and then proceeding with the resection and stapling of the distal part of the tumor. Combined with these canonical functionalities, the new device, equipped with a patented washout system (patent number EP 3103401A1) will also allow to inject in the closed bowel a physiologic saline liquid. In force of the mechanical action of the liquid injected, carcinogenic exfoliated cells eventually floating in the affected region of the colonic lumen will be expelled through the anal orifice. The intraoperative rectal washout, both in minimally invasive and in traditional open surgery, thus becomes a simple, effective, and reproducible procedure. We describe the technical features and the possible clinical applications of a potentially new surgical laparoscopic stapler coupled with an integrated irrigation system. We have patented the system and we are developing a prototype with the aim to start an experimental pilot study.

  6. Characterization of Carbon Dioxide Washout Measurement Techniques in the Mark-III Space Suit

    NASA Technical Reports Server (NTRS)

    Meginnis, I; Norcross, J.; Bekdash, O.

    2016-01-01

    It is essential to provide adequate carbon dioxide (CO2) washout in a space suit to reduce the risks associated with manned operations in space suits. Symptoms of elevated CO2 levels range from reduced cognitive performance and headache to unconsciousness and death at high levels of CO2. Because of this, NASA imposes limits on inspired CO2 levels for space suits when they are used in space and for ground testing. Testing and/or analysis must be performed to verify that a space suit meets CO2 washout requirements. Testing for developmental space suits has traditionally used an oronasal mask that collects CO2 samples at the left and rights sides of the mouth. Testing with this mask resulted in artificially elevated CO2 concentration measurements, which is most likely due to the dead space volume at the front of the mask. The mask also extends outward and into the supply gas stream, which may disrupt the washout effect of the suit supply gas. To mitigate these problems, a nasal cannula was investigated as a method for measuring inspired CO2 based on the assumptions that it is low profile and would not interfere with the designed suit gas flow path, and it has reduced dead space. This test series compared the performance of a nasal cannula to the oronasal mask in the Mark III space suit. Inspired CO2 levels were measured with subjects at rest and at metabolic workloads of 1000, 2000, and 3000 BTU/hr. Workloads were achieved by use of an arm ergometer or treadmill. Test points were conducted at air flow rates of 2, 4, and 6 actual cubic feet per minute, with a suit pressure of 4.3 psid. Results from this test series will evaluate the accuracy and repeatability across subjects of the nasal cannula collection method, which will provide rationale for using a nasal cannula as the new method for measuring inspired CO2 in a space suit. Proper characterization of sampling methods and of suit CO2 washout capability will better inform requirements definition and verification

  7. Plasmid partition system of the P1par family from the pWR100 virulence plasmid of Shigella flexneri.

    PubMed

    Sergueev, Kirill; Dabrazhynetskaya, Alena; Austin, Stuart

    2005-05-01

    P1par family members promote the active segregation of a variety of plasmids and plasmid prophages in gram-negative bacteria. Each has genes for ParA and ParB proteins, followed by a parS partition site. The large virulence plasmid pWR100 of Shigella flexneri contains a new P1par family member: pWR100par. Although typical parA and parB genes are present, the putative pWR100parS site is atypical in sequence and organization. However, pWR100parS promoted accurate plasmid partition in Escherichia coli when the pWR100 Par proteins were supplied. Unique BoxB hexamer motifs within parS define species specificities among previously described family members. Although substantially different from P1parS from the P1 plasmid prophage of E. coli, pWR100parS has the same BoxB sequence. As predicted, the species specificity of the two types proved identical. They also shared partition-mediated incompatibility, consistent with the proposed mechanistic link between incompatibility and species specificity. Among several informative sequence differences between pWR100parS and P1parS is the presence of a 21-bp insert at the center of the pWR100parS site. Deletion of this insert left much of the parS activity intact. Tolerance of central inserts with integral numbers of helical DNA turns reflects the critical topology of these sites, which are bent by binding the host IHF protein.

  8. POPULATION I WOLF-RAYET RUNAWAY STARS: THE CASE OF WR124 AND ITS EXPANDING NEBULA M1-67

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Marchenko, S. V.; Moffat, A. F. J.; Crowther, P. A., E-mail: sergey.marchenko@ssaihq.co, E-mail: moffat@astro.umontreal.c, E-mail: Paul.Crowther@sheffield.ac.u

    2010-11-20

    In 1997 and 2008 we used the WFPC2 camera on board the Hubble Space Telescope to obtain two sets of narrow-band H{alpha} images of the runaway Wolf-Rayet (WR) star WR 124 surrounded by its nebula M1-67. This two-epoch imaging provides an expansion parallax and thus a practically assumption-free geometric distance to the nebula, d = 3.35 {+-} 0.67 kpc. Combined with the global velocity distribution in the ejected nebula, this confirms the extreme runaway status of WR 124. WR stars embedded within such ejection nebulae at the point of core collapse would produce different supernova characteristics from those expected formore » stars surrounded by wind-filled cavities. In galaxies with extremely low ambient metallicity, Z {<=} 10{sup -3} Z {sub sun}, {gamma}-ray bursts originating from fast-moving runaway WR stars may produce afterglows which appear to be coming from regions with a relatively homogeneous circumburst medium.« less

  9. Thyroglobulin assay in fluids from lymph node fine needle-aspiration washout: influence of pre-analytical conditions.

    PubMed

    Casson, Florence Boux de; Moal, Valérie; Gauchez, Anne-Sophie; Moineau, Marie-Pierre; Sault, Corinne; Schlageter, Marie-Hélène; Massart, Catherine

    2017-04-01

    The aim of this study was to evaluate the pre-analytical factors contributing to uncertainty in thyroglobulin measurement in fluids from fine-needle aspiration (FNA) washout of cervical lymph nodes. We studied pre-analytical stability, in different conditions, of 41 samples prepared with concentrated solutions of thyroglobulin (FNA washout or certified standard) diluted in physiological saline solution or buffer containing 6% albumin. In this buffer, over time, no changes in thyroglobulin concentrations were observed in all storage conditions tested. In albumin free saline solution, thyroglobulin recovery rates depended on initial sample concentrations and on modalities of their conservation (in conventional storage tubes, recovery mean was 56% after 3 hours-storage at room temperature and 19% after 24 hours-storage for concentrations ranged from 2 to 183 μg/L; recovery was 95%, after 3 hours or 24 hours-storage at room temperature, for a concentration of 5,656 μg/L). We show here that these results are due to non-specific adsorption of thyroglobulin in storage tubes, which depends on sample protein concentrations. We also show that possible contamination of fluids from FNA washout by plasma proteins do not always adequately prevent this adsorption. In conclusion, non-specific adsorption in storage tubes strongly contributes to uncertainty in thyroglobulin measurement in physiological saline solution. It is therefore recommended, for FNA washout, to use a buffer containing proteins provided by the laboratory.

  10. N-(2-Mercaptoethyl)-1,3-Propanediamine (WR-1065) Protects Thymocytes from Programed Cell Death

    DTIC Science & Technology

    1992-03-15

    and most characteristic biohemical marker for apoptosts is calcium lontophores stimulate a suicide process in nuclear DNA fragmentation Into...1065 the dephosphory- exposed to -7-radiation. dexamethazone. or calcium lated form of WR-2721 and generally considered to be Ionophore A23187. WR...33258 fluorochrome was purchased from Calbiochem-Rehring. La Jolla, CA: Dexameth- azone and calcium lonophore A23 187 were purchased from Sigmatos

  11. Research on wire rope stress distribution of WR-CVT

    NASA Astrophysics Data System (ADS)

    Zhang, Wu; Guo, Wei; Zhang, Chuanwei; Lu, Zhengxiong; Xu, Xiaobin

    2017-10-01

    A wire rope continuously variable transmissions (WR-CVT) has been introduced in the paper, in view of its less research, this paper mainly studied the stress distribution of 6×7+IWS bending wire rope. The results shown that the wire stress is layered distribution in each section, the stress at the outer strand center wire and outer strand side wire was the greatest, the stress value of the outer strand side wire and metal block circular notch is second. As the transmission ratio decreases, the wire stress decreases, which is related to the pulley working radius increases. Compared with the section A1, the stress value on the section A2 is smaller, mainly because the section A2 is not in contact with the metal block or the contact pressure is small. This study provides a basis for the study of fatigue and wears failure of WR-CVT components.

  12. Enhanced Photoacoustic Gas Analyser Response Time and Impact on Accuracy at Fast Ventilation Rates during Multiple Breath Washout

    PubMed Central

    Horsley, Alex; Macleod, Kenneth; Gupta, Ruchi; Goddard, Nick; Bell, Nicholas

    2014-01-01

    Background The Innocor device contains a highly sensitive photoacoustic gas analyser that has been used to perform multiple breath washout (MBW) measurements using very low concentrations of the tracer gas SF6. Use in smaller subjects has been restricted by the requirement for a gas analyser response time of <100 ms, in order to ensure accurate estimation of lung volumes at rapid ventilation rates. Methods A series of previously reported and novel enhancements were made to the gas analyser to produce a clinically practical system with a reduced response time. An enhanced lung model system, capable of delivering highly accurate ventilation rates and volumes, was used to assess in vitro accuracy of functional residual capacity (FRC) volume calculation and the effects of flow and gas signal alignment on this. Results 10–90% rise time was reduced from 154 to 88 ms. In an adult/child lung model, accuracy of volume calculation was −0.9 to 2.9% for all measurements, including those with ventilation rate of 30/min and FRC of 0.5 L; for the un-enhanced system, accuracy deteriorated at higher ventilation rates and smaller FRC. In a separate smaller lung model (ventilation rate 60/min, FRC 250 ml, tidal volume 100 ml), mean accuracy of FRC measurement for the enhanced system was minus 0.95% (range −3.8 to 2.0%). Error sensitivity to flow and gas signal alignment was increased by ventilation rate, smaller FRC and slower analyser response time. Conclusion The Innocor analyser can be enhanced to reliably generate highly accurate FRC measurements down at volumes as low as those simulating infant lung settings. Signal alignment is a critical factor. With these enhancements, the Innocor analyser exceeds key technical component recommendations for MBW apparatus. PMID:24892522

  13. Preparation of hydroxyapatite/collagen injectable bone paste with an anti-washout property utilizing sodium alginate. Part 1: influences of excess supplementation of calcium compounds.

    PubMed

    Sato, Taira; Kikuchi, Masanori; Aizawa, Mamoru

    2017-03-01

    The anti-washout property, viscosity, and cytocompatibility to an osteoblastic cell line, MG-63, of anti-washout pastes were investigated. Mixing a hydroxyapatite/collagen bone-like nanocomposite (HAp/Col), an aqueous solution of sodium alginate (Na-Alg), which is a paste hardening and lubricant agent, and supplementation of calcium carbonate or calcium citrate (Ca-Cit) as a calcium resource for the hardening reaction realized an injectable bone paste. Adding Ca-Cit at a concentration greater than eight times the Ca 2+ ion concentration to Na-Alg improved the anti-washout property. Although the viscosity test indicated a gradual increase in the paste viscosity as the calcium compounds increased, pastes with excess supplementation of calcium compounds exhibited injectability through a syringe with a 1.8 mm inner diameter, realizing an injectable bone filler. Furthermore, the anti-washout pastes with Ca-Cit had almost the same cell proliferation rate as that of the HAp/Col dense body. Therefore, HAp/Col injectable anti-washout pastes composed of the HAp/Col, Na-Alg, and Ca-Cit are potential candidates for bioresorbable bone filler pastes.

  14. Acyclic High-Energy Variability in Eta Carinae and WR 140

    NASA Technical Reports Server (NTRS)

    Corcoran, Michael F.

    2012-01-01

    Eta Carinae and WR 140 are similar long-period colliding wind binaries in which X-ray emission is produced by a strong shock due to the collision of the powerful stellar winds. The change in the orientation and density of this shock as the stars revolve in their orbits influences the X-ray flux and spectrum in a phase dependent way. Monitoring observations with RXTE and other X-ray satellite observatories since the 1990s have detailed this variability but have also shown significant deviations from strict phase dependence (short-term brightness changes or "flares", and cyc1e-to-cyc1e average flux differences). We examine these acylic variations in Eta Car and WR 140 and discuss what they tell us about the stability of the wind-wind collision shock.

  15. Research on wire rope deformation distribution of WR-CVT

    NASA Astrophysics Data System (ADS)

    Zhang, Wu; Guo, Wei; Zhang, Chuanwei; Lu, Zhengxiong; Xu, Xiaobin

    2017-07-01

    A wire rope continuously variable transmissions (WR-CVT) has been introduced in the paper, in view of its less research, this paper mainly studied the deformation distribution of 6×7+IWS bending wire rope. The results shown that in the same section, half of the side strands are in a stretched state and half are in a compressed state. When the transmission ratio i=2.35, the maximum deformation and the minimum deformation are decrease when section U1 to U2, U3 transition. Wire deformation distribution when the transmission ratio i=0.42 is similar to that of i=0.2.35. Wire deformation amount and the deformation difference decrease as the transmission ratio decreases, this shows that the increase in the bending radius of the wire will make the wire deformation more uniform, and the reduction of the deformation difference will also reduce the wear. This study provides a basis for the study of fatigue and wears failure of WR-CVT components.

  16. Hypolipidemic action of chrysin on Triton WR-1339-induced hyperlipidemia in female C57BL/6 mice.

    PubMed

    Zarzecki, Micheli Stéfani; Araujo, Stífani M; Bortolotto, Vandreza C; de Paula, Mariane Trindade; Jesse, Cristiano Ricardo; Prigol, Marina

    2014-01-01

    Chrysin (5,7-dihydroxyflavone) is a flavonoid, natural component of traditional medicinal herbs, present in honey, propolis and many plant extracts. The objective of this study was to investigate the hypolipidemic properties of chrysin on Triton WR-1339-induced hyperlipidemia in female C57BL/6 mice. Triton WR-1339 was administered intraperitoneally (400 mg/kg) to overnight-fasted mice to develop acute hyperlipidemia. Chrysin was administered orally (10 mg/kg) 30 min before Triton WR-1339. At 24 h after Triton WR-1339 injection, blood samples were collected to measure plasma lipid levels. The hepatic thiobarbituric acid reactive substances (TBARS), carbonyl content, non-protein sulfhydryl (NPSH) and ascorbic acid (AA) levels, as well as catalase (CAT) and superoxide dismutase (SOD) activity were recorded. Chrysin administration significantly decreased total cholesterol levels. In addition, it partially decreased non-high density lipoprotein-cholesterol and triglycerides levels in plasma of hyperlipidaemic mice. In addition chrysin administration prevented the increase on TBARS levels and prevented the decrease in SOD activity induced by Triton WR-1339. These findings indicated that chrysin was able to decrease plasma lipids concentration and that its antioxidant properties was, at least in part, involved in the hypolipidaemic action of chrysin.

  17. The washout of combustion-generated hydrogen chloride. [rocket exhaust raindrop scavenging quantification

    NASA Technical Reports Server (NTRS)

    Fenton, D. L.; Purcell, R. Y.; Hrdina, D.; Knutson, E. O.

    1980-01-01

    The coefficient for the washout from a rocket exhaust cloud of HCl generated by the combustion of an ammonium perchlorate-based solid rocket propellant such as that to be used for the Space Shuttle Booster is determined. A mathematical model of HCl scavenging by rain is developed taking into account rain droplet size, fall velocity and concentration under various rain conditions, partitioning of exhaust HCl between liquid and gaseous phases, the tendency of HCl to promote water vapor condensation and the concentration and size of droplets within the exhaust cloud. The washout coefficient is calculated as a function of total cloud water content, total HCl content at 100% relative humidity, condensation nuclei concentration and rain intensity. The model predictions are compared with experimental results obtained in scavenging tests with solid rocket exhaust and raindrops of different sizes, and the large reduction in washout coefficient at high relative humidities predicted by the model is not observed. A washout coefficient equal to 0.0000512 times the -0.176 power of the mass concentration of HCl times the 0.773 power of the rainfall intensity is obtained from the experimental data.

  18. Dynamic contrast-enhanced MRI for differentiation of major salivary glands neoplasms, a 3-T MRI study

    PubMed Central

    Aghaghazvini, L; Salahshour, F; Yazdani, N; Kooraki, S; Pakravan, M; Shakiba, M

    2015-01-01

    Objectives: Pre-operative differentiation of salivary gland neoplasms is of great importance. This study was designed to evaluate the use of dynamic contrast-enhanced MRI (DCE-MRI) for differentiation between malignant, Warthin and benign non-Warthin (BNW) neoplasms of major salivary glands. Methods: 46 major salivary gland tumours (SGTs) underwent pre-operative DCE-MRI. Post-surgical histopathological evaluation showed 30 BNW, 6 Warthin and 10 malignant tumours. Time–signal intensity curves (TICs) were categorized as (a) Tpeak >43 s and washout ratio at 180 s (WR180) <4.6%; (b) Tpeak <43 s and WR >22%; (c) Tpeak >43 s and WR180 = 4.6–22.0% Results: Accuracy of Tpeak was 98.9% for differentiation between BNW and Warthin tumours, 83.7% between BNW and malignant and 80% between malignant and Warthin tumours. All Warthin tumours showed Tpeak ≤43 s, while one BNW had Tpeak <43 s. A Tpeak <63.5 s differentiated 8/10 (80%) malignant tumours from BNW tumours, whereas 4/30 of BNW tumours had a Tpeak <63.5 s. Two malignant tumours had Tpeak <43 s. WR180 had an accuracy of 100% for differentiation between Warthin and BNW tumours, 87.3% between BNW and malignant, and 93.3% between Warthin and malignant tumours. 29 (96.7%) BNW tumours had a washout <4.60%, while 8 (80%) malignant tumours had a washout >4.60%. All Warthin tumours had a WR180 >22%, while two malignant tumours had a WR180 >22%. 29/30 of BNW tumours demonstrated TIC curve Type A and 1 tumour demonstrated Type C. 6/10 of malignant tumours had TIC Type C, 2 had TIC Type A and 2 Type B. All Warthin tumours were categorized as Type B. Conclusions: This study showed that DCE-MRI could be helpful in pre-operative differentiation of SGTs; especially for discrimination between Warthin and BNW tumours. PMID:25299931

  19. Characterization of Carbon Dioxide Washout Measurement Techniques in the Mark-III Space Suit

    NASA Technical Reports Server (NTRS)

    Norcross, J.; Bekdash, O.; Meginnis, I.

    2016-01-01

    Providing adequate carbon dioxide (CO2) washout is essential to the reduction of risk in performing suited operations. Long term CO2 exposure can lead to symptoms such as headache, lethargy, dizziness, and in severe cases can lead to unconsciousness and death. Thus maintaining adequate CO2 washout in both ground testing and during in flight EVAs is a requirement of current and future suit designs. It is necessary to understand the inspired CO2 of suit wearers such that future requirements for space suits appropriately address the risk of inadequate washout. Testing conducted by the EVA Physiology Laboratory at the NASA Johnson Space Center aimed to characterize a method for noninvasively measuring inspired oronasal CO2 under pressurized suited conditions in order to better inform requirements definition and verification techniques for future CO2 washout limits in space suits. Prior work conducted by the EPL examined several different wearable, respirator style, masks that could be used to sample air from the vicinity surround the nose and mouth of a suited test subject. Previously published studies utilized these masks, some being commercial products and some novel designs, to monitor CO2 under various exercise and flow conditions with mixed results for repeatability and/or consistency between subjects. Based on a meta-analysis of those studies it was decided to test a nasal cannula as it is a commercially available device that is placed directly in the flow path of the user as they breathe. A nasal cannula was used to sample air inhaled by the test subjects during both rest and exercise conditions. Eight subjects were tasked with walking on a treadmill or operating an arm ergometer to reach target metabolic rates of 1000, 2000, and 3000 BTU/hr. Suit pressure was maintained at 4.3 psid for all tests, with supply flow rates of 6, 4, and 2 actual cubic feet per minute depending on the test condition. Each test configuration was conducted twice with subjects breathing

  20. Spectral Identification of New Galactic cLBV and WR Stars

    NASA Astrophysics Data System (ADS)

    Stringfellow, G. S.; Gvaramadze, V. V.; Beletsky, Y.; Kniazev, A. Y.

    2012-12-01

    We have undertaken a near-IR spectral survey of stars associated with compact nebulae recently revealed by the Spitzer and WISE imaging surveys. These circumstellar nebulae, produced by massive evolved stars, display a variety of symmetries and shapes and are often only evident at mid-IR wavelengths. Stars associated with ˜50 of these nebulae have been observed. We also obtained recent spectra of previously confirmed (known) luminous blue variables (LBVs) and candidate LBVs (cLBVs). The spectral similarity of the stars observed when compared directly to known LBVs and Wolf-Rayet (WR) stars indicate many are newly identified cLBVs, with a few being newly discovered WR stars, mostly of WN8-9h spectral type. These results suggest that a large population of previously unidentified cLBVs and related transitional stars reside in the Galaxy and confirm that circumstellar nebulae are inherent to most (c)LBVs.

  1. CO2 Washout Testing of the REI and EM-ACES Space Suits

    NASA Technical Reports Server (NTRS)

    Mitchell, Kathryn C.; Norcross, Jason

    2012-01-01

    When a space suit is used during ground testing, adequate carbon dioxide (CO2) washout must be provided for the suited subject. Symptoms of acute CO2 exposure depend on partial pressure of CO2 (ppCO2), metabolic rate of the subject, and other factors. This test was done to characterize inspired oronasal ppCO2 in the Rear Entry I-Suit (REI) and the Enhanced Mobility Advanced Crew Escape Suit (EM-ACES) for a range of workloads and flow rates for which ground testing is nominally performed. Three subjects were tested in each suit. In all but one case, each subject performed the test twice. Suit pressure was maintained at 4.3 psid. Subjects wore the suit while resting, performing arm ergometry, and walking on a treadmill to generate metabolic workloads of about 500 to 3000 BTU/hr. Supply airflow was varied between 6, 5, and 4 actual cubic feet per minute (ACFM) at each workload. Subjects wore an oronasal mask with an open port in front of the mouth and were allowed to breathe freely. Oronasal ppCO2 was monitored in real time by gas analyzers with sampling tubes connected to the mask. Metabolic rate was calculated from the total CO2 production measured by an additional gas analyzer at the suit air outlet. Real-time metabolic rate was used to adjust the arm ergometer or treadmill workload to meet target metabolic rates. In both suits, inspired CO2 was affected mainly by the metabolic rate of the subject: increased metabolic rate significantly (P < 0.05) increased inspired ppCO2. Decreased air flow caused small increases in inspired ppCO2. The effect of flow was more evident at metabolic rates . 2000 BTU/hr. CO2 washout values of the EM-ACES were slightly but not significantly better than those of the REI suit. Regression equations were developed for each suit to predict the mean inspired ppCO2 as a function of metabolic rate and suit flow rate. This paper provides detailed descriptions of the test hardware, methodology, and results as well as implications for future

  2. REVEALING THE ASYMMETRY OF THE WIND OF THE VARIABLE WOLF-RAYET STAR WR1 (HD 4004) THROUGH SPECTROPOLARIZATION

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    St-Louis, N., E-mail: stlouis@astro.umontreal.ca

    In this paper, high quality spectropolarimetric observations of the Wolf-Rayet (WR) star WR1 (HD 4004) obtained with ESPaDOnS at the Canada-France-Hawaii Telescope are presented. All major emission lines present in the spectrum show depolarization in the relative Stokes parameters Q/I and U/I. From the behavior of the amount of line depolarization as a function of line strength, the intrinsic continuum light polarization of WR1 is estimated to be P/I = 0.443% ± 0.028% with an angle of θ = –26.°2. Although such a level of polarization could in principle be caused by a wind flattened by fast rotation, the scenariomore » in which it is a consequence of the presence of corotating interaction regions (CIRs) in the wind is preferred. This is supported by previous photometric and spectroscopic observations showing periodic variations with a period of 16.9 days. This is now the third WR star thought to exhibit CIRs in its wind that is found to have line depolarization. Previous authors have found a strong correlation between line depolarization and the presence of an ejected nebula, which they interpret as a sign that the star has relatively recently reached the WR phase since the nebula are thought to dissipate very fast. In cases where the presence of CIRs in the wind is favored to explain the depolarization across spectral lines, the above-mentioned correlation may indicate that those massive stars have only very recently transited from the previous evolutionary phase to the WR phase.« less

  3. Isocapnic hyperventilation shortens washout time for sevoflurane - an experimental in vivo study.

    PubMed

    Hallén, K; Stenqvist, O; Ricksten, S-E; Lindgren, S

    2016-10-01

    Isocapnic hyperventilation (IHV) is a method that fastens weaning from inhalation anaesthesia by increasing airway concentration of carbon dioxide (CO2 ) during hyperventilation (HV). In an animal model, we evaluated a technique of adding CO2 directly to the breathing circuit of a standard anaesthesia apparatus. Eight anaesthetised pigs weighing 28 ± 2 kg were intubated and mechanically ventilated. From a baseline ventilation of 5 l/min, HV was achieved by doubling minute volume and fresh gas flow. Respiratory rate was increased from 15 to 22/min. The CO2 absorber was disconnected and CO2 was delivered (DCO2 ) to the inspiratory limb of a standard breathing circuit via a mixing box. Time required to decrease end-tidal sevoflurane concentration from 2.7% to 0.2% was defined as washout time. Respiration and haemodynamics were monitored by blood gas analysis, spirometry, electric impedance tomography and pulse contour analysis. A DCO2 of 261 ± 19 ml/min was necessary to achieve isocapnia during HV. The corresponding FICO2 -level remained stable at 3.1 ± 0.3%. During IHV, washout of sevoflurane was three times faster, 433 ± 135 s vs. 1387 ± 204 s (P < 0.001). Arterial CO2 tension and end-tidal CO2 , was 5.2 ± 0.4 kPa and 5.6 ± 0.4%, respectively, before IHV and 5.1 ± 0.3 kPa and 5.7 ± 0.3%, respectively, during IHV. In this experimental in vivo model of isocapnic hyperventilation, the washout time of sevoflurane anaesthesia was one-third compared to normal ventilation. The method for isocapnic hyperventilation described can potentially be transferred to a clinical setting with the intention to decrease emergence time from inhalation anaesthesia. © 2016 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

  4. Early surgical suction and washout for treatment of cytotoxic drug extravasations.

    PubMed

    Vandeweyer, E; Deraemaecker, R

    2000-02-01

    This case report is presented to assess safety and efficiency of early suction and saline washout of extravasated cytotoxic drugs. Through multiple small skin incisions, the area of extravasation is first suctioned and subsequently extensively washed out with saline. Incisions are left open and the arm is elevated for 24 hours. A complete healing was obtained in five days without any skin or soft tissue loss. No additional treatment was needed. Early referral and surgical treatment by suction and washout is a safe and reliable treatment protocol for major cytotoxic drug extravasation injuries.

  5. Washout of hepatocellular carcinoma on portal venous phase of multidetector computed tomography in a pre-transplant population.

    PubMed

    Kitzing, Yu Xuan; Ng, Bernard H K; Kitzing, Bjoern; Waugh, Richard; Kench, James G; Strasser, Simone I; McCormack, Samuel

    2015-12-01

    Washout is an important diagnostic imaging feature of hepatocellular carcinoma (HCC) on computed tomography (CT). The primary aim of this study is to evaluate the prevalence and the interobserver variation in the detection of portal venous phase (PVP) washout of HCCs using CT in a transplant population. The secondary aim is to evaluate factors influencing the detection of PVP washout. Forty-five patients who underwent CT liver imaging within the 60 days before transplantation had viable HCCs confirmed on pathology. Two radiologists retrospectively reviewed the images for HCCs including features of arterial enhancement and PVP washout. Clinical data, peak kilovoltage, imaging features of portal hypertension, region of interest attenuation measurements of the individual lesions, background liver parenchyma and portal vein were obtained. Liver to lesion attenuation ratio was also calculated. Statistical analysis was performed. The two readers identified 50 arterially enhancing HCCs in 45 patients. In consensus, the two readers identified washout in 60% of the HCCs with a substantial interobserver agreement (kappa = 0.633). PVP washout was associated with larger lesion size, increased background liver parenchyma attenuation, increased liver to lesion attenuation ratio, increased portal vein attenuation and hepatitis B viral status (P = 0.027, 0.008, 0.014, 0.017 and 0.037 respectively). In our transplant population, portal venous phase washout was seen in 60% of the hypervascular HCCs. Factors influencing the presence of PVP washout include lesion size as well as the liver and portal vein attenuation reflective of the portal haemodynamics. © 2015 The Royal Australian and New Zealand College of Radiologists.

  6. Evaluation of the Impact of Alveolar Nitrogen Excretion on Indices Derived from Multiple Breath Nitrogen Washout

    PubMed Central

    Nielsen, Niklas; Nielsen, Jorgen G.; Horsley, Alex R.

    2013-01-01

    Background A large body of evidence has now accumulated describing the advantages of multiple breath washout tests over conventional spirometry in cystic fibrosis (CF). Although the majority of studies have used exogenous sulphur hexafluoride (SF6) as the tracer gas this has also led to an increased interest in nitrogen washout tests, despite the differences between these methods. The impact of body nitrogen excreted across the alveoli has previously been ignored. Methods A two-compartment lung model was developed that included ventilation heterogeneity and dead space (DS) effects, but also incorporated experimental data on nitrogen excretion. The model was used to assess the impact of nitrogen excretion on washout progress and accuracy of functional residual capacity (FRC) and lung clearance index (LCI) measurements. Results Excreted nitrogen had a small effect on accuracy of FRC (1.8%) in the healthy adult model. The error in LCI calculated with true FRC was greater (6.3%), and excreted nitrogen contributed 21% of the total nitrogen concentration at the end of the washout. Increasing DS and ventilation heterogeneity both caused further increase in measurement error. LCI was increased by 6–13% in a CF child model, and excreted nitrogen increased the end of washout nitrogen concentration by 24–49%. Conclusions Excreted nitrogen appears to have complex but clinically significant effects on washout progress, particularly in the presence of abnormal gas mixing. This may explain much of the previously described differences in washout outcomes between SF6 and nitrogen. PMID:24039916

  7. CO2 Washout Testing of the REI and EM-ACES Space Suits

    NASA Technical Reports Server (NTRS)

    Mitchell, Kate; Norcross, Jason

    2011-01-01

    Requirements for using a space suit during ground testing include providing adequate carbon dioxide (CO2) washout for the suited subject. Acute CO2 exposure can lead to symptoms including headache, dyspnea, lethargy and eventually unconsciousness or even death. Symptoms depend on several factors including partial pressure of CO2 (ppCO2), duration of exposure, metabolic rate of the subject and physiological differences between subjects. The objective of this test was to characterize inspired oronasal ppCO2 in the Rear Entry I-Suit (REI) and the Enhanced Mobility Advanced Crew Escape Suit (EM-ACES) across a range of workloads and flow rates for which ground testing is nominally performed. Three subjects were tested in each suit. In all but one case, each subject performed the test twice to allow for comparison between tests. Suit pressure was maintained at 4.3 psid. Subjects wore the suit while resting, performing arm ergometry, and walking on a treadmill to generate metabolic workloads of approximately 500 to 3000 BTU/hr. Supply airflow was varied at 6, 5 and 4 actual cubic feet per minute (ACFM) at each workload. Subjects wore an oronasal mask with an open port in front of the mouth and were allowed to breathe freely. Oronasal ppCO2 was monitored real-time via gas analyzers with sampling tubes connected to the oronasal mask. Metabolic rate was calculated from the total CO2 production measured by an additional gas analyzer at the air outlet from the suit. Real-time metabolic rate was used to adjust the arm ergometer or treadmill workload to meet target metabolic rates. In both suits, inspired CO2 was primarily affected by the metabolic rate of the subject, with increased metabolic rate resulting in increased inspired ppCO2. Suit flow rate also affected inspired ppCO2, with decreased flow causing small increases in inspired ppCO2. The effect of flow was more evident at metabolic rates greater than or equal to 2000 BTU/hr. Results were consistent between suits, with

  8. A phase I study of WR-2721 in combination with total body irradiation (TBI) in patients with refractory lymphoid malignancies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Coia, L.; Krigel, R.; Hanks, G.

    This Phase I study was designed to establish the maximum tolerated dose (MTD) of WR-2721 when given twice weekly with total body irradiation (TBI) in the treatment of patients with advanced refractory lymphoid malignancies and to define the toxicities of this combination and schedule. Patients eligible for this study had advanced recurrent indolent non-Hodgkin's lymphoma (NHL) or chronic lymphocytic leukemia (CLL). Patients had symptomatic or progressive disease, a performance status of 0, 1, or 2, and adequate bone marrow, hepatic, and renal function. Only patients failing one or two regimens of prior chemotherapy were eligible. Patients who had received priormore » extended field irradiation were ineligible. Patients received TBI twice weekly (Tuesday and Friday) to a total of 10 doses at 15 cGy/fx. WR-2721 was given intravenously over 15 min beginning 30 min before irradiation. The escalation of WR-2721 was Level 1: 740 mg/m2 and Level 2: 910 mg/m2. The MTD of WR-2721 was that dose which produced predictable and reversible toxicity and would not interfere with patient well-being. Seven patients were entered onto the study, three at 740 mg/m2 and four at 910 mg/m2. Five patients had CLL and two patients small lymphocytic NHL. No patient had hypotension or nausea requiring reduction in dose level or even interruption of infusion of WR-2721. At 740 mg/m2 no grade 3 or 4 toxicities related to WR-2721 were observed, but two patients could not complete treatment because of TBI-induced prolonged thrombocytopenia following treatments 5 and 8. One patient completed all 10 treatments. At 910 mg/m2 of WR-2721, two patients requested removal from study because of malaise, one after 5 cycles and one after 7 cycles. One patient completed all 10 treatments.« less

  9. [Development of a Computer-aided Diagnosis System to Distinguish between Benign and Malignant Mammary Tumors in Dynamic Magnetic Resonance Images: Automatic Detection of the Position with the Strongest Washout Effect in the Tumor].

    PubMed

    Miyazaki, Yoshiaki; Tabata, Nobuyuki; Taroura, Tomomi; Shinozaki, Kenji; Kubo, Yuichiro; Tokunaga, Eriko; Taguchi, Kenichi

    We propose a computer-aided diagnostic (CAD) system that uses time-intensity curves to distinguish between benign and malignant mammary tumors. Many malignant tumors show a washout pattern in time-intensity curves. Therefore, we designed a program that automatically detects the position with the strongest washout effect using the technique, such as the subtraction technique, which extracts only the washout area in the tumor, and by scanning data in 2×2 pixel region of interest (ROI). Operation of this independently developed program was verified using a phantom system that simulated tumors. In three cases of malignant tumors, the washout pattern detection rate in images with manually set ROI was ≤6%, whereas the detection rate with our novel method was 100%. In one case of a benign tumor, when the same method was used, we checked that there was no washout effect and detected the persistent pattern. Thus, the distinction between benign and malignant tumors using our method was completely consistent with the pathological diagnoses made. Our novel method is therefore effective for differentiating between benign and malignant mammary tumors in dynamic magnetic resonance images.

  10. Analytical evaluation of two motion washout techniques

    NASA Technical Reports Server (NTRS)

    Young, L. R.

    1977-01-01

    Practical tools were developed which extend the state of the art of moving base flight simulation for research and training purposes. The use of visual and vestibular cues to minimize the actual motion of the simulator itself was a primary consideration. The investigation consisted of optimum programming of motion cues based on a physiological model of the vestibular system to yield 'ideal washout logic' for any given simulator constraints.

  11. Combined technetium radioisotope penile plethysmography and xenon washout: A technique for evaluating corpora cavernosal inflow and outflow during early tumescence

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schwartz, A.N.; Graham, M.M.

    1991-03-01

    Combined technetium radioisotope penile plethysmography and xenon washout is a new technique that measures both corporal arterial inflow and venous sinusoidal outflow during early tumescence in patients with erectile dysfunction. Fourteen patients were studied using 99mTc-RBCs to measure inflow and 133Xe or 127Xe in saline to measure outflow. Tumescence was induced by injecting papaverine intracorporally. Peak corporal rates corrected for inflow (r = 0.88) and uncorrected for outflow (r = 0.91) and change in volume over 2 min centered around peak inflow (r = 0.96) all correlated with angiography. Outflow measurements did not correlate with intracorporal resistance. Thus, outflow ratesmore » alone could not be used to predict venous sinusoidal competence. Normal inflow rate is greater than 20 ml/min; probable normal 12-20; indeterminate inflow 7-12; and abnormal inflow less than 7 ml/min. Technetium-99m radioisotope penile plethysmography and xenon washout can be performed together and both provide a method for simultaneously evaluating the relationship between corporal inflow and outflow rates in patients with erectile dysfunction.« less

  12. Cisplatin neuropathy. Risk factors, prognosis, and protection by WR-2721

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mollman, J.E.; Glover, D.J.; Hogan, W.M.

    1988-06-01

    A prospective study of patients receiving cis-diaminedichloroplatin II (DDP) was carried out to determine if risk factors could be identified related to the patient's living habits or past medical history that would predict in which patients DDP neuropathy might develop. Sixty-nine patients receiving six different combinations of chemotherapeutic agents, including DDP were examined. Twenty-eight of these patients received DDP in combination with the radioprotective agent S-2-(3-aminopropylamino)-ethylphosporothioic acid (WR 2721). No risk factors were identified relating to personal habits or past medical history of the patients. However, patients receiving DDP (40 mg/m2) on 5 consecutive days had a significantly higher incidencemore » of neuropathy. Patients receiving DDP in combination with WR 2721 had a significantly lower incidence of neuropathy, and the mean dose at onset was significantly higher than the mean dose at onset of neuropathy for all other groups. In addition, five of six patients who were available for long-term follow-up demonstrated nearly complete reversal of the signs and symptoms of neuropathy.« less

  13. Effects of WR1065 on 6-hydroxydopamine-induced motor imbalance: Possible involvement of oxidative stress and inflammatory cytokines.

    PubMed

    Kheradmand, Afshin; Nayebi, Alireza M; Jorjani, Masoumeh; Khalifeh, Solmaz; Haddadi, Rasool

    2016-08-03

    Over production of reactive oxygen species (ROS) is postulated to be the main contributor in degeneration of nigrostriatal dopaminergic neurons. In this study we investigated the effects of WR1065, a free radical scavenger, on motor imbalance, oxidative stress parameters and inflammatory cytokines in CSF and brain of hemi-parkinsonian rats. Lesion of dopaminergic neurons was done by unilateral infusion of 6-hydroxydopamine into the central region of the substentia nigra pars compacta (SNc) to induce hemi-parkinsonism and motor imbalance in rats. WR1065 (20, 40 and 80μg/2μl/rat) was administered three days before 6-OHDA administration. After three weeks behavioral study was performed and then brain and CSF samples were collected to assess tumor necrosis factor (TNFα), interlukin (IL-1β), reduced glutathione (GSH), and malondialdehyde (MDA). WR1065 pre-treatment in rats before receiving 6-OHDA, improved significantly motor impairment and caused reduction of MDA and inflammatory cytokines TNFα and IL-1β levels, while GSH level significantly increased when compared with lesioned rats. Our study indicated that WR1065 could improve 6-OHDA-induced motor imbalance. Furthermore, it decreased lipid peroxidation and inflammatory cytokines and restored the level of GSH up to normal range. We suggest that WR1065 can be proposed as a potential neuroprotective agent in motor impairments of PD. However to prove this hypothesis more clinical trial studies should be done. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  14. CO2 Washout Testing Using Various Inlet Vent Configurations in the Mark-III Space Suit

    NASA Technical Reports Server (NTRS)

    Korona, F. Adam; Norcross, Jason; Conger, Bruce; Navarro, Moses

    2014-01-01

    Requirements for using a space suit during ground testing include providing adequate carbon dioxide (CO2) washout for the suited subject. Acute CO2 exposure can lead to symptoms including headache, dyspnea, lethargy and eventually unconsciousness or even death. Symptoms depend on several factors including inspired partial pressure of CO2 (ppCO2), duration of exposure, metabolic rate of the subject and physiological differences between subjects. Computational Fluid Dynamic (CFD) analysis has predicted that the configuration of the suit inlet vent has a significant effect on oronasal CO2 concentrations. The main objective of this test is to characterize inspired oronasal ppCO2 for a variety of inlet vent configurations in the Mark-III space suit across a range of workload and flow rates. As a secondary objective, results will be compared to the predicted CO2 concentrations and used to refine existing CFD models. These CFD models will then be used to help design an inlet vent configuration for the Z-2 space suit, which maximizes oronasal CO2 washout. This test has not been completed, but is planned for January 2014. The results of this test will be incorporated into this paper. The testing methodology used in this test builds upon past CO2 washout testing performed on the Z-1 suit, Rear Entry I-Suit (REI) and the Enhanced Mobility Advanced Crew Escape Suit (EM-ACES). Three subjects will be tested in the Mark-III space suit with each subject performing two test sessions to allow for comparison between tests. Six different helmet inlet vent configurations will be evaluated during each test session. Suit pressure will be maintained at 4.3 psid. Subjects will wear the suit while walking on a treadmill to generate metabolic workloads of approximately 2000 and 3000 BTU/hr. Supply airflow rates of 6 and 4 actual cubic feet per minute (ACFM) will be tested at each workload. Subjects will wear an oronasal mask with an open port in front of the mouth and will be allowed to

  15. Analysis of heart rate and oxygen uptake kinetics studied by two different pseudo-random binary sequence work rate amplitudes.

    PubMed

    Drescher, U; Koschate, J; Schiffer, T; Schneider, S; Hoffmann, U

    2017-06-01

    The aim of the study was to compare the kinetics responses of heart rate (HR), pulmonary (V˙O 2 pulm) and predicted muscular (V˙O 2 musc) oxygen uptake between two different pseudo-random binary sequence (PRBS) work rate (WR) amplitudes both below anaerobic threshold. Eight healthy individuals performed two PRBS WR protocols implying changes between 30W and 80W and between 30W and 110W. HR and V˙O 2 pulm were measured beat-to-beat and breath-by-breath, respectively. V˙O 2 musc was estimated applying the approach of Hoffmann et al. (Eur J Appl Physiol 113: 1745-1754, 2013) considering a circulatory model for venous return and cross-correlation functions (CCF) for the kinetics analysis. HR and V˙O 2 musc kinetics seem to be independent of WR intensity (p>0.05). V˙O 2 pulm kinetics show prominent differences in the lag of the CCF maximum (39±9s; 31±4s; p<0.05). A mean difference of 14W between the PRBS WR amplitudes impacts venous return significantly, while HR and V˙O 2 musc kinetics remain unchanged. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. PROBING WOLF–RAYET WINDS: CHANDRA/HETG X-RAY SPECTRA OF WR 6

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Huenemoerder, David P.; Schulz, N. S.; Gayley, K. G.

    With a deep Chandra/HETGS exposure of WR 6, we have resolved emission lines whose profiles show that the X-rays originate from a uniformly expanding spherical wind of high X-ray-continuum optical depth. The presence of strong helium-like forbidden lines places the source of X-ray emission at tens to hundreds of stellar radii from the photosphere. Variability was present in X-rays and simultaneous optical photometry, but neither were correlated with the known period of the system or with each other. An enhanced abundance of sodium revealed nuclear-processed material, a quantity related to the evolutionary state of the star. The characterization of themore » extent and nature of the hot plasma in WR 6 will help to pave the way to a more fundamental theoretical understanding of the winds and evolution of massive stars.« less

  17. LM1-64: a Newly Reported Lmc-Pn with WR Nucleus

    NASA Astrophysics Data System (ADS)

    Pena, M.; Olguin, L.; Ruiz, M. T.; Torres-Peimbert, S.

    1993-05-01

    The object LM1-64 was reported by Lindsay & Mullan (1963, Irish Astron. J., 5, 51) as a probable PN in the LMC. Optical and UV spectra taken by us confirm that suggestion. LM1-64 is a high excitation planetary nebulae which shows evidence of having a WC central star. Broad stellar emission at lambda 4650 is detected in the optical spectrum obtained with the CTIO 4m telescope, in 1989. A UV spectrum in the range from 1200 Angstroms to 2000 Angstroms was obtained with IUE in 1990. We have measured all the emission line fluxes available and determined values for the physical conditions and chemical abundances of the nebular ionized gas. The derived values are T(OIII) = 14000K, log He/H = 11.05, log C/H = 9.48, log O/H = 8.55 and log Ne/H = 7.94. LM1-64 shows a large C enhancement in the envelope as result of the central star activity, while He, O and Ne are comparable to the average values reported for the LMC-PNe (Monk, Barlow & Clegg, 1988, MNRAS, 234, 583). We have estimated the He II Zanstra temperature of the central star to be ~ 80,000 K. This temperature is much higher than the values reported for the known LMC-PNe with WR nucleus that Monk et al. have classified as W4 to W8. The only other high temperature WR nucleus in a LMC-PN is N66 which recently showed evidence of undergoing a WR episode (Torres-Peimbert, Ruiz, Peimbert & Pe\\ na, 1993, IAU Symp. 155, eds. A. Acker & R. Weinberger, in press).

  18. Washout Ratio in the Hepatic Vein Measured by Contrast-Enhanced Ultrasonography to Distinguish Between Inflammatory and Noninflammatory Hepatic Disorders in Dogs.

    PubMed

    Morishita, K; Hiramoto, A; Michishita, A; Takagi, S; Osuga, T; Lim, S Y; Nakamura, K; Sasaki, N; Ohta, H; Takiguchi, M

    2017-05-01

    Perflubutane microbubbles, a second-generation ultrasound contrast agent, are phagocytized by Kupffer cells. This characteristic may be useful to differentiate diffuse hepatic diseases in dogs. To determine whether the washout ratio in the hepatic vein (HV) measured by contrast-enhanced ultrasonography (CEUS) can distinguish between inflammatory and noninflammatory hepatic disorders in dogs. Forty-one client-owned dogs with hepatic disorders including 14 with hepatitis, 7 with primary hypoplasia of the portal vein (PHPV), 9 with congenital portosystemic shunt (cPSS), and 11 with other hepatopathy were enrolled. Six dogs without hepatic disease also were evaluated as healthy controls. Dogs with hepatic disorders were prospectively included. Contrast-enhanced ultrasonography of the HV was performed for 2 minutes. Washout ratio was defined as the attenuation rate from peak intensity to the intensity at the end of the CEUS study. Washout ratio in the hepatitis group (median, 18.0%; range, 2.0-37.0%) was significantly lower than that of the PHPV (median, 52.2%; range, 11.5-86.3%), cPSS (median, 60.0%; range, 28.6-77.4%), other hepatopathy (median, 70.5%; range, 26.6-88.4%), and normal (median, 78.0%; range, 60.7-91.7%) groups. The area under the receiver operating characteristic curve for hepatitis was 0.960, with a 95% confidence interval (CI) of 0.853-0.990. Washout ratio ≤37.1% resulted in a sensitivity of 100% (95% CI, 78.5-100%) and specificity of 85.2% (95% CI, 67.5-94.1%) for the prediction of hepatitis. Washout ratio can distinguish hepatitis from the other noninflammatory disorders with high accuracy. This result might reflect impaired Kupffer cell phagocytosis in dogs with hepatitis. Copyright © 2017 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

  19. Comparison of flow and gas washout characteristics between pressure control and high-frequency percussive ventilation using a test lung

    PubMed Central

    Dutta, Rabijit; Xing, Tao; Swanson, Craig; Heltborg, Jeff; Murdoch, Gordon K

    2018-01-01

    Objective A comparison between flow and gas washout data for high-frequency percussive ventilation (HFPV) and pressure control ventilation (PCV) under similar conditions is currently not available. This bench study aims to compare and describe the flow and gas washout behavior of HFPV and PCV in a newly designed experimental setup and establish a framework for future clinical and animal studies. Approach We studied gas washout behavior using a newly designed experimental setup that is motivated by the multi-breath nitrogen washout measurements. In this procedure, a test lung was filled with nitrogen gas before it was connected to a ventilator. Pressure, volume, and oxygen concentrations were recorded under different compliance and resistance conditions. PCV was compared with two settings of HFPV, namely, HFPV-High and HFPV-Low, to simulate the different variations in its clinical application. In the HFPV-Low mode, the peak pressures and drive pressures of HFPV and PCV are matched, whereas in the HFPV-High mode, the mean airway pressures (MAP) are matched. Main results HFPV-Low mode delivers smaller tidal volume (VT) as compared to PCV under all lung conditions, whereas HFPV-High delivers a larger VT. HFPV-High provides rapid washout as compared to PCV under all lung conditions. HFPV-Low takes a longer time to wash out nitrogen except at a low compliance, where it expedites washout at a smaller VT and MAP compared to PCV washout. Significance Various flow parameters for HFPV and PCV are mathematically defined. A shorter washout time at a small VT in low compliant test lungs for HFPV could be regarded as a hypothesis for lung protective ventilation for animal or human lungs. PMID:29369819

  20. Comparison of flow and gas washout characteristics between pressure control and high-frequency percussive ventilation using a test lung.

    PubMed

    Dutta, Rabijit; Xing, Tao; Swanson, Craig; Heltborg, Jeff; Murdoch, Gordon K

    2018-03-15

    A comparison between flow and gas washout data for high-frequency percussive ventilation (HFPV) and pressure control ventilation (PCV) under similar conditions is currently not available. This bench study aims to compare and describe the flow and gas washout behavior of HFPV and PCV in a newly designed experimental setup and establish a framework for future clinical and animal studies. We studied gas washout behavior using a newly designed experimental setup that is motivated by the multi-breath nitrogen washout measurements. In this procedure, a test lung was filled with nitrogen gas before it was connected to a ventilator. Pressure, volume, and oxygen concentrations were recorded under different compliance and resistance conditions. PCV was compared with two settings of HFPV, namely, HFPV-High and HFPV-Low, to simulate the different variations in its clinical application. In the HFPV-Low mode, the peak pressures and drive pressures of HFPV and PCV are matched, whereas in the HFPV-High mode, the mean airway pressures (MAP) are matched. HFPV-Low mode delivers smaller tidal volume (V T ) as compared to PCV under all lung conditions, whereas HFPV-High delivers a larger V T . HFPV-High provides rapid washout as compared to PCV under all lung conditions. HFPV-Low takes a longer time to wash out nitrogen except at a low compliance, where it expedites washout at a smaller V T and MAP compared to PCV washout. Various flow parameters for HFPV and PCV are mathematically defined. A shorter washout time at a small V T in low compliant test lungs for HFPV could be regarded as a hypothesis for lung protective ventilation for animal or human lungs.

  1. Neutrino jets from high-mass WR gauge bosons in TeV-scale left-right symmetric models

    NASA Astrophysics Data System (ADS)

    Mitra, Manimala; Ruiz, Richard; Scott, Darren J.; Spannowsky, Michael

    2016-11-01

    We reexamine the discovery potential at hadron colliders of high-mass right-handed (RH) gauge bosons WR—an inherent ingredient of left-right symmetric models (LRSM). We focus on the regime where the WR is very heavy compared to the heavy Majorana neutrino N , and we investigate an alternative signature for WR→N decays. The produced neutrinos are highly boosted in this mass regime. Subsequently, their decays via off-shell WR bosons to jets, i.e., N →ℓ±jj, are highly collimated, forming a single neutrino jet (jN). The final-state collider signature is then ℓ±jN, instead of the widely studied ℓ±ℓ±j j . Present search strategies are not sensitive to this hierarchical mass regime due to the breakdown of the collider signature definition. We take into account QCD corrections beyond next-to-leading order (NLO) that are important for high-mass Drell-Yan processes at the 13 TeV Large Hadron Collider (LHC). For the first time, we evaluate WR production at NLO with threshold resummation at next-to-next-to-leading logarithm (NNLL) matched to the threshold-improved parton distributions. With these improvements, we find that a WR of mass MWR=3 (4 )[5 ] TeV and mass ratio of (mN/MWR)<0.1 can be discovered with a 5 - 6 σ statistical significance at 13 TeV after 10 (100 )[2000 ] fb-1 of data. Extending the analysis to the hypothetical 100 TeV Very Large Hadron Collider (VLHC), 5 σ can be obtained for WR masses up to MW R=15 (30 ) with approximately 100 fb-1 (10 ab-1 ). Conversely, with 0.9 (10 )[150 ] fb-1 of 13 TeV data, MWR<3 (4 )[5 ] TeV and (mN/MWR)<0.1 can be excluded at 95% C.L.; with 100 fb-1 (2.5 ab-1 ) of 100 TeV data, MW R<22 (33 ) TeV can be excluded.

  2. Analytic model for washout of HCl(g) from dispersing rocket exhaust clouds

    NASA Technical Reports Server (NTRS)

    Pellett, G. L.

    1981-01-01

    The potential is investigated that precipitation scavenging of HCl from large solid rocket exhaust clouds may result in unacceptably acidic rain in the Cape Canaveral, Florida, area before atmospheric dispersion reduces HCl concentrations to safe limits. Several analytic expressions for HCl(g) and HCl(g + aq) washout are derived; a geometric mean washout coefficient is recommended. A previous HCl washout model is refined and applied to a space shuttle case (70 t HCl exhausted up to 4 km) and eight Titan 3 (60 percent less exhaust) dispersion cases. The vertical column density (sigma) decays were deduced by application of a multilayer Gaussian diffusion model to seven standard meteorological regimes for overland advection. The Titan 3 decays of sigma and initial rain pH differed greatly among regimes; e.g., a range of 2 pH units was spanned at x 100 km downwind and t = 2 hr. Environmentally significant pH's .5 for infrequent exposures were shown possible at X = 50 km and t 5 hr for the two least dispersive Titan 3 cases. Representative examples of downwind rainwater pH and G(X) are analyzed. Factors affecting the validity of the results are discussed.

  3. Detached dust shell around Wolf-Rayet star WR60-6 in the young stellar cluster VVV CL036

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Borissova, J.; Amigo, P.; Kurtev, R.

    The discovery of a detached dust shell around the Wolf-Rayet (WR) star WR60-6 in the young stellar cluster VVV CL036 is reported. This shell is uncovered through the Spitzer-MIPS 24 μm image, where it appears brightest, and it is invisible at shorter wavelengths. Using new APEX observations and other data available from the literature, we have estimated some of the shell parameters: the inner and outer radii of 0.15 and 0.90 pc, respectively; the overall systemic velocity of the molecular {sup 12}CO(3 → 2) emission of –45.7 ± 2.3 km s{sup –1}; an expansion velocity of the gas of 16.3more » ± 1 km s{sup –1}; the dust temperature and opacity of 122 ± 12 K and 1.04, respectively; and an age of 2.8 × 10{sup 4} yr. The WR star displays some cyclic variability. The mass computed for the WR60-6 nebula indicates that the material was probably ejected during its previous stages of evolution. In addition, we have identified a bright spot very close to the shell, which can be associated with the Midcourse Space Experiment source G312.13+00.20.« less

  4. WR 20a Is an Eclipsing Binary: Accurate Determination of Parameters for an Extremely Massive Wolf-Rayet System

    NASA Astrophysics Data System (ADS)

    Bonanos, A. Z.; Stanek, K. Z.; Udalski, A.; Wyrzykowski, L.; Żebruń, K.; Kubiak, M.; Szymański, M. K.; Szewczyk, O.; Pietrzyński, G.; Soszyński, I.

    2004-08-01

    We present a high-precision I-band light curve for the Wolf-Rayet binary WR 20a, obtained as a subproject of the Optical Gravitational Lensing Experiment. Rauw et al. have recently presented spectroscopy for this system, strongly suggesting extremely large minimum masses of 70.7+/-4.0 and 68.8+/-3.8 Msolar for the component stars of the system, with the exact values depending strongly on the period of the system. We detect deep eclipses of about 0.4 mag in the light curve of WR 20a, confirming and refining the suspected period of P=3.686 days and deriving an inclination angle of i=74.5d+/-2.0d. Using these photometric data and the radial velocity data of Rauw et al., we derive the masses for the two components of WR 20a to be 83.0+/-5.0 and 82.0+/-5.0 Msolar. Therefore, WR 20a is confirmed to consist of two extremely massive stars and to be the most massive binary known with an accurate mass determination. Based on observations obtained with the 1.3 m Warsaw telescope at Las Campanas Observatory, which is operated by the Carnegie Institute of Washington.

  5. First Visual Orbit for the Prototypical Colliding-wind Binary WR 140

    NASA Astrophysics Data System (ADS)

    Monnier, John D.; Zhao, M.; Pedretti, E.; Millan-Gabet, R.; Berger, J.; Schloerb, F.; Traub, W.; ten Brummelaar, T.; McAlister, H.; Ridgway, S.; Turner, N.; Sturmann, L.; Sturmann, J.; Baron, F.; Tannirkulam, A.; Kraus, S.; Williams, P.

    2012-01-01

    Wolf-Rayet stars represent one of the final stages of massive stellar evolution. Relatively little is known about this short-lived phase and we currently lack reliable mass, distance, and binarity determinations for a representative sample. Here we report the first visual orbit for WR 140 (=HD193793), a WC7+O5 binary system known for its periodic dust production episodes triggered by intense colliding winds near periastron passage. The IOTA and CHARA interferometers resolved the pair of stars in each year from 2003--2009, covering most of the highly-eccentric, 7.9 year orbit. Combining our results with the recent improved double-line spectroscopic orbit of Fahed et al. (2011), we can estimate the distance to WR 140 with about 2% error and estimate component masses with about 4% error. Our precision orbit yields key parameters with uncertainties about 6 times smaller than previous work and paves the way for detailed modeling of the system. Our newly measured flux ratios at the near-infrared H and Ks bands allow an SED decomposition and analysis of the component evolutionary states.

  6. Effects of S-2-(3-Methylaminopropylamino)ethyl Phosphorothioic Acid (WR- 3689), Alone or Combined with Caffeine, on Catecholamine Content of Mouse Hypothalamus

    DTIC Science & Technology

    1993-01-01

    INSTITUTE I cIEINTIFIC•IEPOET SR93-16 Effects of S-2-(3-Methylaminopropylamino)ethyl Phosphorothioic Acid (WR-3689), Alone or Combined with Caffeine...and 220 pg/mg and 69 and 94 pg/mg of hypothalamic tissue, respectively. WR- 3689 had no effect on the content of NE and DA. In contrast, NE increased...increased to 142 ± 13 pg/mg (P < 0.05) 4 hr after injection of 40 mg/kg of caffeine. The combination of WR-3689 and caffeine had no effect on NE and DA

  7. Comparative behavioral toxicity of four sulfhydryl radioprotective compounds in mice: Wr2721, cysteamine, diethyldithiocarbamate, and n-acetylcysteine

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Landauer, M.R.; Davis, H.D.; Dominitz, J.A.

    1988-01-01

    A number of sulfhydryl compounds have been shown to protect against ionizing radiation. One of the most effective radioprotectors is S-2(3-aminopropylamino)ethylphosphorothioic acid, also known aas ethiofos, gammaphos, or WR-2721 (Davidson, 1980; Giambarresi and Jacobs, 1987). This drug is currently under clinical investigation for its potential in protecting normal tissue during radiation treatment and chemotherapy (Blumberg et al., 1982; Glover et al., 1988; Yuhas et al., 1980). B-Mercaptoethylamine (MEA, cysteamine) was for years the standard against which the effectiveness of other radioprotectors was judged, but is more toxic than WR-2721 (Giambarresi and Jacobs, 1987). Diethyldithiocarbamate (DDC) and N-acetylcysteine (NAC) are othermore » compounds shown to have radioprotective properties (Milas et al., 1988; Weiss et al., 1984). Studies in a variety of animal species have shown significant behavioral toxicity after administration of WR-2721 (Bogo et al., 1985; Bogo, 1988; Landauer et al., 1987b, 1988).« less

  8. Prophylaxis of Plasmodium falciparum Infection in a Human Challenge Model with WR 238605, a New 8-Aminoquinoline Antimalarial

    PubMed Central

    Brueckner, Ralf P.; Coster, Trinka; Wesche, David L.; Shmuklarsky, Moshe; Schuster, Brian G.

    1998-01-01

    The prophylactic efficacy of WR 238605, a primaquine analog, was studied with a human Plasmodium falciparum challenge model. A single oral dose of 600 mg, administered 1 day prior to challenge, successfully protected three of four subjects. The fourth subject developed mild, oligosymptomatic malaria on day 31, with drug concentrations one-half of those in the protected individuals. WR 238605 appears to be a promising prophylactic drug for P. falciparum malaria. PMID:9593172

  9. Analysis of metabolic washout of positron emitters produced during carbon ion head and neck radiotherapy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Helmbrecht, Stephan; Enghardt, Wolfgang; Parodi, Katia

    2013-09-15

    Purpose: Particle Therapy Positron Emission Tomography (PT-PET) is a suitable method for verification of therapeutic dose delivery by measurements of irradiation-induced β{sup +}-activity. Due to metabolic processes in living tissue β{sup +}-emitters can be removed from the place of generation. This washout is a limiting factor for image quality. The purpose of this study is to investigate whether a washout model obtained by animal experiments is applicable to patient data.Methods: A model for the washout has been developed by Mizuno et al. [Phys. Med. Biol. 48(15), 2269–2281 (2003)] and Tomitani et al. [Phys. Med. Biol. 48(7), 875–889 (2003)]. It ismore » based upon measurements in a rabbit in living and dead conditions. This model was modified and applied to PET data acquired during the experimental therapy project at GSI Helmholtzzentrum für Schwerionenforschung Darmstadt, Germany. Three components are expected: A fast one with a half life of 2 s, a medium one in the range of 2–3 min, and a slow component of the order of 2–3 h. Ten patients were selected randomly for investigation of the fast component. To analyze the other two components, 12 one-of-a-kind measurements from a single volunteer patient are available.Results: A fast washout on the time scale of a few seconds was not observed in the patient data. The medium processes showed a mean half life of 155.7 ± 4.6 s. This is in the expected range. Fractions of the activity not influenced by the washout were found.Conclusions: On the time scale of an in-beam or in-room measurement only the medium-time washout processes play a remarkable role. A slow component may be neglected if the measurements do not exceed 20 min after the end of the irradiation. The fast component is not observed due to the low relative blood filled volume in the brain.« less

  10. Tidal volume single breath washout of two tracer gases--a practical and promising lung function test.

    PubMed

    Singer, Florian; Stern, Georgette; Thamrin, Cindy; Fuchs, Oliver; Riedel, Thomas; Gustafsson, Per; Frey, Urs; Latzin, Philipp

    2011-03-10

    Small airway disease frequently occurs in chronic lung diseases and may cause ventilation inhomogeneity (VI), which can be assessed by washout tests of inert tracer gas. Using two tracer gases with unequal molar mass (MM) and diffusivity increases specificity for VI in different lung zones. Currently washout tests are underutilised due to the time and effort required for measurements. The aim of this study was to develop and validate a simple technique for a new tidal single breath washout test (SBW) of sulfur hexafluoride (SF(6)) and helium (He) using an ultrasonic flowmeter (USFM). The tracer gas mixture contained 5% SF(6) and 26.3% He, had similar total MM as air, and was applied for a single tidal breath in 13 healthy adults. The USFM measured MM, which was then plotted against expired volume. USFM and mass spectrometer signals were compared in six subjects performing three SBW. Repeatability and reproducibility of SBW, i.e., area under the MM curve (AUC), were determined in seven subjects performing three SBW 24 hours apart. USFM reliably measured MM during all SBW tests (n = 60). MM from USFM reflected SF(6) and He washout patterns measured by mass spectrometer. USFM signals were highly associated with mass spectrometer signals, e.g., for MM, linear regression r-squared was 0.98. Intra-subject coefficient of variation of AUC was 6.8%, and coefficient of repeatability was 11.8%. The USFM accurately measured relative changes in SF(6) and He washout. SBW tests were repeatable and reproducible in healthy adults. We have developed a fast, reliable, and straightforward USFM based SBW method, which provides valid information on SF(6) and He washout patterns during tidal breathing.

  11. Tidal Volume Single Breath Washout of Two Tracer Gases - A Practical and Promising Lung Function Test

    PubMed Central

    Singer, Florian; Stern, Georgette; Thamrin, Cindy; Fuchs, Oliver; Riedel, Thomas; Gustafsson, Per; Frey, Urs; Latzin, Philipp

    2011-01-01

    Background Small airway disease frequently occurs in chronic lung diseases and may cause ventilation inhomogeneity (VI), which can be assessed by washout tests of inert tracer gas. Using two tracer gases with unequal molar mass (MM) and diffusivity increases specificity for VI in different lung zones. Currently washout tests are underutilised due to the time and effort required for measurements. The aim of this study was to develop and validate a simple technique for a new tidal single breath washout test (SBW) of sulfur hexafluoride (SF6) and helium (He) using an ultrasonic flowmeter (USFM). Methods The tracer gas mixture contained 5% SF6 and 26.3% He, had similar total MM as air, and was applied for a single tidal breath in 13 healthy adults. The USFM measured MM, which was then plotted against expired volume. USFM and mass spectrometer signals were compared in six subjects performing three SBW. Repeatability and reproducibility of SBW, i.e., area under the MM curve (AUC), were determined in seven subjects performing three SBW 24 hours apart. Results USFM reliably measured MM during all SBW tests (n = 60). MM from USFM reflected SF6 and He washout patterns measured by mass spectrometer. USFM signals were highly associated with mass spectrometer signals, e.g., for MM, linear regression r-squared was 0.98. Intra-subject coefficient of variation of AUC was 6.8%, and coefficient of repeatability was 11.8%. Conclusion The USFM accurately measured relative changes in SF6 and He washout. SBW tests were repeatable and reproducible in healthy adults. We have developed a fast, reliable, and straightforward USFM based SBW method, which provides valid information on SF6 and He washout patterns during tidal breathing. PMID:21423739

  12. Prognostic value of cardiac sympathetic nerve activity evaluated by [123I]m-iodobenzylguanidine imaging in patients with ST-segment elevation myocardial infarction.

    PubMed

    Kasama, Shu; Toyama, Takuji; Sumino, Hiroyuki; Kumakura, Hisao; Takayama, Yoshiaki; Minami, Kazutomo; Ichikawa, Shuichi; Matsumoto, Naoya; Sato, Yuichi; Kurabayashi, Masahiko

    2011-01-01

    Many studies have shown that cardiac sympathetic nerve activity evaluated by [(123)I]m-iodobenzylguanidine ([(123)I]MIBG) scintigraphic study during a stable period is useful for determining the prognosis of patients with chronic heart failure. To examine whether results of this imaging method performed 3 weeks after the onset of ST-segment elevation myocardial infarction (STEMI) are a reliable prognostic marker for patients with STEMI. The study analysed findings for 213 consecutive patients with STEMI undergoing [(123)I]MIBG scintigraphy. The left ventricular (LV) end-diastolic and end-systolic volume and LV ejection fraction (EF) were determined by left ventriculography or echocardiography 3 weeks after the onset of STEMI. The delayed total defect score, heart-to-mediastinum ratio and washout rate (WR) were also determined from [(123)I]MIBG scintigraphy at the same time. Of the 213 patients, 46 experienced major adverse cardiac events (MACE) during the study. The median follow-up period was 982 days. Patients were divided into an event-free group (n = 167; 78.4%) and a MACE group (n = 46; 21.6%). The LV and [(123)I]MIBG scintigraphic parameters in the event-free group were better than those in the MACE group. Multivariate Cox regression analyses revealed that WR was a significant predictor of MACE along with oral nicorandil (ATP-sensitive potassium channel opener) treatment and undergoing percutaneous coronary intervention. On Kaplan-Meier analysis, the event-free rate of patients with a WR<40% was significantly higher than that in patients with a WR ≥ 40% (p<0.001). Even when confined to patients with LVEF>45%, WR was a predictor of MACE, pump failure death, cardiac death and progression of heart failure in patients with STEMI. WR evaluated by [(123)I]MIBG scintigraphy 3 weeks after the onset of STEMI is a significant predictor of MACE in patients with STEMI, independent of LVEF.

  13. Modelling the colliding-wind spectra of the WC8d+O8-9IV binary CV Ser (WR 113)

    NASA Astrophysics Data System (ADS)

    Hill, G. M.; Moffat, A. F. J.; St-Louis, N.

    2018-03-01

    Striking profile variations of the C III λ5696 emission line are visible amongst the high signal-to-noise ratio, moderate resolution spectra of the 29.7 d WC8d+O8-9IV binary CV Ser (WR 113) presented here. Using a significantly revised code, we have modelled these variations assuming the emission originates from the undisturbed WR star wind and a colliding wind shock region that partially wraps around the O star. Changes to the modelling code are chiefly in the form of additional parameters, intended to refine the modelling and facilitate comparison with recent predictions arising from theoretical and hydrodynamical work. This modelling provides measurements of crucial parameters such as the orbital inclination (63.5° ± 2.5°) and thus, together with the RV orbits, the stellar masses (11.7 ± 0.9 M⊙ for the WR star and 33.3 ± 2.0 M⊙ for the O star). We find good agreement with expectations based on theoretical studies and hydrodynamical modelling of colliding wind systems. Moreover, it raises the exciting prospect of providing a reliable method to learn more about WR stellar masses and winds, and for studying the physics of colliding winds in massive stars.

  14. 123I-BMIPP delayed scintigraphic imaging in patients with chronic heart failure.

    PubMed

    Kida, Keisuke; Akashi, Yoshihiro J; Yoneyama, Kihei; Shimokawa, Mitsuhiro; Musha, Haruki

    2008-11-01

    The objective of the present study was to clarify the ability of 123I-beta-methyl-iodophenylpentadecanoic acid (123I-BMIPP) to evaluate the heart-to-mediastinum (H/M) ratio and myocardial global washout rate (WR) in patients with chronic heart failure (CHF). The severity of CHF was evaluated on the basis of the New York Heart Association (NYHA) classification. Twenty patients with CHF (13 with idiopathic dilated cardiomyopathy and 7 with ischemic cardiomyopathy) and 11 age-matched controls underwent myocardial radionuclide imaging. Scintigraphic images were obtained from each participant at the early (30 min following radio-isotope injection) and late (4 h) phases using 123I-BMIPP. The H/M ratio and WR were calculated from planar images. Concentrations of plasma brain natriuretic peptide (BNP) were measured prior to the scintigraphic study. The 123I-BMIPP uptake of early H/M and global WR did not significantly differ among groups, but uptake of delayed H/M was significantly lower in patients with NYHA class III than in controls (control 2.47 +/- 0.39; class III 1.78 +/- 0.28, P < 0.05). The uptake of delayed H/M and global WR correlated with plasma log BNP in all participants (r = -0.38, P < 0.05; 0.43, P < 0.05, respectively). These data suggest that 123I-BMIPP uptake of delayed H/M enhances the image of CHF severity. The myocardial WR of 123I-BMIPP also effectively depicted the severity of CHF.

  15. Statistical comparison of pooled nitrogen washout data of various altitude decompression response groups

    NASA Technical Reports Server (NTRS)

    Edwards, B. F.; Waligora, J. M.; Horrigan, D. J., Jr.

    1985-01-01

    This analysis was done to determine whether various decompression response groups could be characterized by the pooled nitrogen (N2) washout profiles of the group members, pooling individual washout profiles provided a smooth time dependent function of means representative of the decompression response group. No statistically significant differences were detected. The statistical comparisons of the profiles were performed by means of univariate weighted t-test at each 5 minute profile point, and with levels of significance of 5 and 10 percent. The estimated powers of the tests (i.e., probabilities) to detect the observed differences in the pooled profiles were of the order of 8 to 30 percent.

  16. Prophylactic activity of mefloquine hydrochloride (WR 142 490) in drug-resistant malaria*

    PubMed Central

    Rieckmann, K. H.; Trenholme, G. M.; Williams, R. L.; Carson, P. E.; Frischer, H.; Desjardins, R. E.

    1974-01-01

    In preliminary studies with mefloquine (WR 142 490) a single dose exerted prolonged suppressive activity against a drug-resistant strain of Plasmodium falciparum. Development of patent parasitaemia was prevented when nonimmune persons were exposed to infected mosquitos 2 weeks after medication, and it was delayed when exposure occurred 3 weeks after drug administration. PMID:4619059

  17. Ventilatory inhomogeneity determined from multiple-breath washouts during sustained microgravity on Spacelab SLS-1.

    PubMed

    Prisk, G K; Guy, H J; Elliott, A R; Paiva, M; West, J B

    1995-02-01

    We used multiple-breath N2 washouts (MBNW) to study the inhomogeneity of ventilation in four normal humans (mean age 42.5 yr) before, during, and after 9 days of exposure to microgravity on Spacelab Life Sciences-1. Subjects performed 20-breath MBNW at tidal volumes of approximately 700 ml and 12-breath MBNW at tidal volumes of approximately 1,250 ml. Six indexes of ventilatory inhomogeneity were derived from data from 1) distribution of specific ventilation (SV) from mixed-expired and 2) end-tidal N2, 3) change of slope of N2 washout (semilog plot) with time, 4) change of slope of normalized phase III of successive breaths, 5) anatomic dead space, and 6) Bohr dead space. Significant ventilatory inhomogeneity was seen in the standing position at normal gravity (1 G). When we compared standing 1 G with microgravity, the distributions of SV became slightly narrower, but the difference was not significant. Also, there were no significant changes in the change of slope of the N2 washout, change of normalized phase III slopes, or the anatomic and Bohr dead spaces. By contrast, transition from the standing to supine position in 1 G resulted in significantly broader distributions of SV (P < 0.05) and significantly greater changes in the changes in slope of the N2 washouts (P < 0.001), indicating more ventilatory inhomogeneity in that posture. Thus these techniques can detect relatively small changes in ventilatory inhomogeneity. We conclude that the primary determinants of ventilatory inhomogeneity during tidal breathing in the upright posture are not gravitational in origin.

  18. Ventilatory inhomogeneity determined from multiple-breath washouts during sustained microgravity on Spacelab SLS-1

    NASA Technical Reports Server (NTRS)

    Prisk, G. Kim; Guy, Harold J. B.; Elliott, Ann R.; Paiva, Manuel; West, John B.

    1995-01-01

    We used multiple-breath N2 washouts (MBNW) to study the homogeneity of ventilation in four normal humans (mean age 42.5 yr) before, during, and after 9 days of exposure to microgravity on Spacelab Life Sciences-1. Subjects performed 20-breath MBNW at tidal volumes of approximately 700 ml and 12-breath MBNW at tidal volumes of approximately 1,250 ml. Six indexes of ventilatory inhomogeneity were derived from data from (1) distribution of specific ventilation (SV) from mixed-expired and (2) end-tidal N2, (3) change of slope of N2 washout (semilog plot) with time, (4) change of slope of normalized phase III of successive breaths, (5) anatomic lead dead space, and (6) Bohr dead space. Significant ventilatory inhomogeneity was seen in the standing position at normal gravity (1 G). When we compared standing 1 G with microgravity, the distributions of SV became slightly narrower, but the difference was not significant. Also, there were no significant changes in the change of slope of the N2 washout, change of normalized phase III slopes, or the anatomic and Bohr dead spaces. By contrast, transition from the standing to supine position in 1 G resulted in significantly broader distributions of SV and significantly greater changes in the changes in slope of the N2 washouts, indicating more ventilatory inhomogeneity in that posture. Thus these techniques can detect relatively small changes in ventilatory inhomogeneity. We conclude that the primary determinants of ventilatory inhomogeneity during tidal breathing in the upright posture are not gravitational in origin.

  19. LEW.1WR1 RATS DEVELOP AUTOIMMUNE DIABETES SPONTANEOUSLY AND IN RESPONSE TO ENVIRONMENTAL PERTURBATION

    PubMed Central

    Mordes, John P.; Leif, Jean H.; Woda, Bruce A.; Flanagan, Joan F.; Greiner, Dale L.; Kislauskis, Edward H.; Tirabassi, Rebecca S.

    2005-01-01

    We describe a new rat model of autoimmune diabetes that arose in a major histocompatibility complex (MHC) congenic LEW rat. Spontaneous diabetes in LEW.1WR1 rats (RT1u/u/a) occurs with a cumulative frequency of ∼2% at a median age of 59 days. The disease is characterized by hyperglycemia, glycosuria, ketonuria and polyuria. Both sexes are affected, and islets of acutely diabetic rats are devoid of beta cells whereas alpha and delta cell populations are spared. The peripheral lymphoid phenotype is normal, including the fraction of ART2+ regulatory T cells (Tregs). We tested the hypothesis that the expression of diabetes would be increased by immunological perturbation of innate or adaptive immunity. Treatment of young rats with depleting anti-ART2.1 mAb increased the frequency of diabetes to 50%. Treatment with the toll-like receptor 3 (TLR3) ligand polyinosinic:polycytidylic acid increased the frequency of diabetes to 100%. All diabetic rats exhibited end-stage islets. The LEW.1WR1 rat is also susceptible to collagen-induced arthritis but is free of spontaneous thyroiditis. The LEW.1WR1 rat provides a new model for studying autoimmune diabetes and arthritis in an animal with a genetic predisposition to both disorders that can be amplified by environmental perturbation. PMID:16123363

  20. The wash-out of emissions from the atmosphere by precipitation

    Treesearch

    Ladislav Hanu& #154; ka; Eva Nov& #225; kov& #225; ; Nov& #225; kov& #225; Eva NO-VALUE

    1976-01-01

    We investigated the mechanism and dynamics of solid particles, emissions, and the concentrations of sulphur dioxide as integral components of the contamination of atmosphere. The only way of decontamination is the wash-out by precipitation (solid - snow, liquid - rain). We started from the items of information acquired during the studies of snow acidity in mountain...

  1. [Protective effects of WR2721 on early bone marrow hematopoietic function in mice exposed to 6.5 Gy of (60)Co γ-rays].

    PubMed

    Deng, Zi-Liang; Zhang, Liu-Zhen; Cong, Yue; Liu, Xiao-Lan; Yu, Zu-Ying; Shan, Ya-Jun; Cui, Yu; Wang, Li-Mei; Xing, Shuang; Cong, Yu-Wen; Luo, Qing-Liang

    2014-06-01

    The aim of this study was to investigate the effect of WR2721(amifostine) against bone marrow hematopoietic damage of mice exposed to 6.5 Gy of (60)Co-γ ray. A total of 60 C57/BL6J mice was divided into 3 groups:normal group (mice were injected with physiological salt solution), irradiation group (mice were injected with physiologic salt solution before irradiation) and WR2721 group (mice were injected with WR2721 before irradiation). The WBC, neutrophil (Neut), Plt and RBC levels in peripheral blood of 3 group mice were counted within 60 days after irradiation; the bone marrow nuclear cells (BMNC) were counted at 2 and 24 hours after irradiation; the hematopoietic stem/progenitor cell (LK/LSK) level and colony formation capability were detected by flow cytometry at 2 and 24 hours after irradiation. The results indicated that the counts of WBC and neut at 4 and 18 days, Plt at 7-18 days and RBC at 10-30 day after irradiation in WR2721 group were higher than those in irradiation group (P < 0.05); the BMNC, LSK and LK levels obviously increased at 24 hours after irradiation (P < 0.05), the CFU-GEMM, CFU-GM, CFU-MK BFU-E and CFU-E all significantly increased at 2 and 24 hours after irradiation (P < 0.01), as compared with irradiation group. It is concluded that WR2721 can effectively alleviate early hematopoietic damage and promote the fast recovery of peripheral blood cells in mice exposed to γ-ray, suggesting that the WR2721 has significant radioprotective effect on hematopoietic system.

  2. The contribution of site to washout and rainout: Precipitation chemistry based on sample analysis from 0.5 mm precipitation increments and numerical simulation

    NASA Astrophysics Data System (ADS)

    Aikawa, Masahide; Kajino, Mizuo; Hiraki, Takatoshi; Mukai, Hitoshi

    2014-10-01

    Datasets of precipitation chemistry at a precipitation resolution of 0.5 mm from three sites were studied to determine whether the washout and rainout mechanisms differed with site type (urban, suburban, rural). Rainout accounted for approximately one-third of the total NO3- deposition and washout contributed two-thirds, irrespective of the site type, although the washout contribution at the urban site (over 70%) was larger than that at the other two sites. The rainout mechanism and the washout mechanism both accounted for about half the total SO42- deposition at the suburban and rural sites, whereas at the urban site the rainout contribution was over 80%. A chemical transport model produced similar levels of washout and rainout contributions as the precipitation chemistry data.

  3. Coupling hydrodynamics with comoving frame radiative transfer. I. A unified approach for OB and WR stars

    NASA Astrophysics Data System (ADS)

    Sander, A. A. C.; Hamann, W.-R.; Todt, H.; Hainich, R.; Shenar, T.

    2017-07-01

    Context. For more than two decades, stellar atmosphere codes have been used to derive the stellar and wind parameters of massive stars. Although they have become a powerful tool and sufficiently reproduce the observed spectral appearance, they can hardly be used for more than measuring parameters. One major obstacle is their inconsistency between the calculated radiation field and the wind stratification due to the usage of prescribed mass-loss rates and wind-velocity fields. Aims: We present the concepts for a new generation of hydrodynamically consistent non-local thermodynamical equilibrium (non-LTE) stellar atmosphere models that allow for detailed studies of radiation-driven stellar winds. As a first demonstration, this new kind of model is applied to a massive O star. Methods: Based on earlier works, the PoWR code has been extended with the option to consistently solve the hydrodynamic equation together with the statistical equations and the radiative transfer in order to obtain a hydrodynamically consistent atmosphere stratification. In these models, the whole velocity field is iteratively updated together with an adjustment of the mass-loss rate. Results: The concepts for obtaining hydrodynamically consistent models using a comoving-frame radiative transfer are outlined. To provide a useful benchmark, we present a demonstration model, which was motivated to describe the well-studied O4 supergiant ζPup. The obtained stellar and wind parameters are within the current range of literature values. Conclusions: For the first time, the PoWR code has been used to obtain a hydrodynamically consistent model for a massive O star. This has been achieved by a profound revision of earlier concepts used for Wolf-Rayet stars. The velocity field is shaped by various elements contributing to the radiative acceleration, especially in the outer wind. The results further indicate that for more dense winds deviations from a standard β-law occur.

  4. The washout effects of rainfall on atmospheric particulate pollution in two Chinese cities.

    PubMed

    Guo, Ling-Chuan; Zhang, Yonghui; Lin, Hualiang; Zeng, Weilin; Liu, Tao; Xiao, Jianpeng; Rutherford, Shannon; You, Jing; Ma, Wenjun

    2016-08-01

    Though rainfall is recognized as one of the main mechanisms to reduce atmospheric particulate pollution, few studies have quantified this effect, particularly the corresponding lag effect and threshold. This study aimed to investigate the association between rainfall and air quality using a distributed lag non-linear model. Daily data on ambient PM2.5 and PM2.5-10 (particulate matter with an aerodynamic diameter less than 2.5 μm and from 2.5 to 10 μm) and meteorological factors were collected in Guangzhou and Xi'an from 2013 to 2014. A better washout effect was found for PM2.5-10 than for PM2.5, and the rainfall thresholds for both particle fractions were 7 mm in Guangzhou and 1 mm in Xi'an. The decrease in PM2.5 levels following rain lasted for 3 and 6 days in Guangzhou and Xi'an, respectively. Rainfall had a better washout effect in Xi'an compared with that in Guangzhou. Findings from this study contribute to a better understanding of the washout effects of rainfall on particulate pollution, which may help to understand the category and sustainability of dust-haze and enforce anthropogenic control measures in time. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. Bayesian population analysis of a washin-washout physiologically based pharmacokinetic model for acetone

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Moerk, Anna-Karin, E-mail: anna-karin.mork@ki.s; Jonsson, Fredrik; Pharsight, a Certara company, St. Louis, MO

    2009-11-01

    The aim of this study was to derive improved estimates of population variability and uncertainty of physiologically based pharmacokinetic (PBPK) model parameters, especially of those related to the washin-washout behavior of polar volatile substances. This was done by optimizing a previously published washin-washout PBPK model for acetone in a Bayesian framework using Markov chain Monte Carlo simulation. The sensitivity of the model parameters was investigated by creating four different prior sets, where the uncertainty surrounding the population variability of the physiological model parameters was given values corresponding to coefficients of variation of 1%, 25%, 50%, and 100%, respectively. The PBPKmore » model was calibrated to toxicokinetic data from 2 previous studies where 18 volunteers were exposed to 250-550 ppm of acetone at various levels of workload. The updated PBPK model provided a good description of the concentrations in arterial, venous, and exhaled air. The precision of most of the model parameter estimates was improved. New information was particularly gained on the population distribution of the parameters governing the washin-washout effect. The results presented herein provide a good starting point to estimate the target dose of acetone in the working and general populations for risk assessment purposes.« less

  6. CO2 Washout Testing Using Various Inlet Vent Configurations in the Mark-III Space Suit

    NASA Technical Reports Server (NTRS)

    Korona, F. Adam; Norcross, Jason; Conger, Bruce; Navarro, Moses

    2014-01-01

    Requirements for using a space suit during ground testing include providing adequate carbon dioxide (CO2) washout for the suited subject. Acute CO2 exposure can lead to symptoms including headache, dyspnea, lethargy and eventually unconsciousness or even death. Symptoms depend on several factors including inspired partial pressure of CO2 (ppCO2), duration of exposure, metabolic rate of the subject and physiological differences between subjects. Computational Fluid Dynamic (CFD) analysis has predicted that the configuration of the suit inlet vent has a significant effect on oronasal CO2 concentrations. The main objective of this test was to characterize inspired oronasal ppCO2 for a variety of inlet vent configurations in the Mark-III suit across a range of workload and flow rates. Data and trends observed during testing along with refined CFD models will be used to help design an inlet vent configuration for the Z-2 space suit. The testing methodology used in this test builds upon past CO2 washout testing performed on the Z-1 suit, Rear Entry I-Suit (REI) and the Enhanced Mobility Advanced Crew Escape Suit (EM-ACES). Three subjects performed two test sessions each in the Mark-III suit to allow for comparison between tests. Six different helmet inlet vent configurations were evaluated during each test session. Suit pressure was maintained at 4.3 psid. Suited test subjects walked on a treadmill to generate metabolic workloads of approximately 2000 and 3000 BTU/hr. Supply airflow rates of 6 and 4 actual cubic feet per minute (ACFM) were tested at each workload. Subjects wore an oronasal mask with an open port in front of the mouth and were allowed to breathe freely. Oronasal ppCO2 was monitored real-time via gas analyzers with sampling tubes connected to the oronasal mask. Metabolic rate was calculated from the total oxygen consumption and CO2 production measured by additional gas analyzers at the air outlet from the suit. Realtime metabolic rate measurements were

  7. Carbon Dioxide Washout Testing Using Various Inlet Vent Configurations in the Mark-III Space Suit

    NASA Technical Reports Server (NTRS)

    Korona, F. Adam; Norcross, Jason; Conger, Bruce; Navarro, Moses

    2014-01-01

    Requirements for using a space suit during ground testing include providing adequate carbon dioxide (CO2) washout for the suited subject. Acute CO2 exposure can lead to symptoms including headache, dyspnea, lethargy, and eventually unconsciousness or even death. Symptoms depend on several factors including inspired partial pressure of CO2 (ppCO2), duration of exposure, metabolic rate of the subject, and physiological differences between subjects. Computational Fluid Dynamics (CFD) analysis has predicted that the configuration of the suit inlet vent has a significant effect on oronasal CO2 concentrations. The main objective of this test was to characterize inspired oronasal ppCO2 for a variety of inlet vent configurations in the Mark-III suit across a range of workload and flow rates. Data and trends observed during testing along with refined CFD models will be used to help design an inlet vent configuration for the Z-2 space suit. The testing methodology used in this test builds upon past CO2 washout testing performed on the Z-1 suit, Rear Entry I-Suit, and the Enhanced Mobility Advanced Crew Escape Suit. Three subjects performed two test sessions each in the Mark-III suit to allow for comparison between tests. Six different helmet inlet vent configurations were evaluated during each test session. Suit pressure was maintained at 4.3 psid. Suited test subjects walked on a treadmill to generate metabolic workloads of approximately 2000 and 3000 BTU/hr. Supply airflow rates of 6 and 4 actual cubic feet per minute were tested at each workload. Subjects wore an oronasal mask with an open port in front of the mouth and were allowed to breathe freely. Oronasal ppCO2 was monitored real-time via gas analyzers with sampling tubes connected to the oronasal mask. Metabolic rate was calculated from the CO2 production measured by an additional gas analyzer at the air outlet from the suit. Real-time metabolic rate measurements were used to adjust the treadmill workload to meet

  8. CO2 Washout Testing Using Various Inlet Vent Configurations in the Mark-III Space Suit

    NASA Technical Reports Server (NTRS)

    Korona, F. Adam; Norcross, Jason; Conger, Bruce; Navarro, Moses

    2014-01-01

    Requirements for using a space suit during ground testing include providing adequate carbon dioxide (CO2) washout for the suited subject. Acute CO2 exposure can lead to symptoms including headache, dyspnea, lethargy and eventually unconsciousness or even death. Symptoms depend on several factors including inspired partial pressure of CO2 (ppCO2), duration of exposure, metabolic rate of the subject and physiological differences between subjects. Computational Fluid Dynamic (CFD) analysis has predicted that the configuration of the suit inlet vent has a significant effect on oronasal CO2 concentrations. The main objective of this test was to characterize inspired oronasal ppCO2 for a variety of inlet vent configurations in the Mark-III suit across a range of workload and flow rates. Data and trends observed during testing along with refined CFD models will be used to help design an inlet vent configuration for the Z-2 space suit. The testing methodology used in this test builds upon past CO2 washout testing performed on the Z-1 suit, Rear Entry I-Suit (REI) and the Enhanced Mobility Advanced Crew Escape Suit (EM-ACES). Three subjects performed two test sessions each in the Mark-III suit to allow for comparison between tests. Six different helmet inlet vent configurations were evaluated during each test session. Suit pressure was maintained at 4.3 psid. Suited test subjects walked on a treadmill to generate metabolic workloads of approximately 2000 and 3000 BTU/hr. Supply airflow rates of 6 and 4 actual cubic feet per minute (ACFM) were tested at each workload. Subjects wore an oronasal mask with an open port in front of the mouth and were allowed to breathe freely. Oronasal ppCO2 was monitored real-time via gas analyzers with sampling tubes connected to the oronasal mask. Metabolic rate was calculated from the total oxygen consumption and CO2 production measured by additional gas analyzers at the air outlet from the suit. Real-time metabolic rate measurements were

  9. The enigmatic WR46: A binary or a pulsator in disguise. II. The spectroscopy

    NASA Astrophysics Data System (ADS)

    Veen, P. M.; van Genderen, A. M.; Crowther, P. A.; van der Hucht, K. A.

    2002-04-01

    , we discern a flaring behaviour, i.e., an emission bump appeared on the blue wing of two He Ii-lines (around -1700 km s-1) lasting less than 5 min. Finally, the line fluxes follow the observed brightenings, also on a time scale of years. We conclude that the short-term cyclic variability confirms the WR nature as established from the WR standard model analysis by Crowther et al. (\\cite{Crowther95}; hereafter referred to as CSH). The various time-delay effects are consistent with the formation of the spectrum in a stratified stellar wind. The outer layers trail the inner ones. The variability is inconsistent with the formation of the spectrum in a stellar disc as proposed by Niemela et al. (\\cite{Niemela95}) and Steiner & Diaz (\\cite{Steiner98}). The long-term cyclic variability of the brightness and line fluxes is related to an increase of the mass-loss-rate, and, possibly, to the period changes. The interpretation of the nature of the variability is deferred to Veen et al. (\\cite{Veen02b}, Paper III). Based on observations collected at the European Southern Observatory (ESO), La Silla, Chile.

  10. Radiation protection of murine intestine by WR-2721, 16,16-dimethyl prostaglandin E2, and the combination of both agents

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hanson, W.R.

    1987-08-01

    The survival of murine intestinal clonogenic cells (ICC) and the survival of mice after whole-body exposure to /sup 137/Cs irradiation were used to measure radiation protection by ethiophos (WR-2721), 16,16-dimethyl prostaglandin E2, and the combination of the two. Doses from 2 to 12.5 mg/mouse of WR-2721 increased cell survival linearly from 3.2 +/- 0.3 in controls given 15.0 Gy to 93.1 +/- 5.2 per jejunal circumference. In contrast, 16,16-dm PGE2 increased ICC survival at 15.0 Gy rapidly from 1 to 10 micrograms/mouse, followed by a plateau up to 100 micrograms/mouse. Animal survival at 6 days (LD50/6) increased from 16.3 +/-more » 0.4 Gy (95% confidence limits) in controls to 20.3 +/- 0.6 Gy in the PG-treated animals. WR-2721 increased the LD50/6 to 26.1 +/- 1.4 Gy. The dose modification factors were 1.25 and 1.60, respectively. The combination of agents increased ICC survival above that seen with each agent alone up to 8 mg WR-2721, above which no additional protection was seen. Animals given 10 micrograms PG plus 10 mg WR-2721 survived longer than with either agent given alone. The LD50/6 was 36.3 +/- 1.8 Gy for a dose modification factor (DMF) of 2.23. In addition, the slope of the probit curve was reduced from those of each agent alone. PG-induced changes in villus epithelial cell morphology and survival may account, in part, for these observations. The results suggest that either the mechanisms for these two types of radiation protectors are different or they act on separate subcellular targets which are critical to survival from radiation injury.« less

  11. Similar Hydrodynamic and Morphological Changes in the Aqueous Humor Outflow Pathway after Washout and Y27632 Treatment in Monkey Eyes

    PubMed Central

    Lu, Zhaozeng; Zhang, Yuyan; Freddo, Thomas F.; Gong, Haiyan

    2011-01-01

    Our previous studies in bovine eyes demonstrated that the structural correlate to the increase in outflow facility after either Rho-kinase inhibitor Y-27632 (Y27) treatment or washout appeared to be separation between the juxtacanalicular tissue (JCT) and inner wall (IW) of the aqueous plexus, the bovine equivalent of Schlemm's canal (SC). While these findings suggest that Y27 and washout may increase outflow facility through a similar mechanism, the anatomy of bovine outflow pathway differs considerably from both the human and monkey outflow pathway; however, only the human eye does not exhibit washout. In light of this, we compared the effects of Y27 and washout on outflow facility, hydrodynamic patterns of outflow, and the morphology of the IW and JCT in monkey eyes, given that their anatomy is closer to human eyes. Twelve freshly enucleated monkey eyes were used in this study. Eyes were perfused with Dulbecco's PBS containing 5.5 mM glucose (GPBS) to establish a baseline facility at 15 mmHg. Four eyes were perfused for a short-duration (30 min) as a control, 4 eyes for a long-duration (180 min) to induce washout, and 4 eyes with GPBS+50 μM Y27 for 30 min. All eyes were then perfused with fluorescent microspheres (0.5μm; 0.002%) to label the hydrodynamic patterns of outflow and then perfusion-fixed. Confocal images of frontal sections were taken along the IW of SC. The total length (TL) and the tracer decorated length (FL) of the IW were measured to calculate the average percent effective filtration length (PEFL=FL/TL). Sections with SC were examined by light and electron microscopy. The TL of the IW and the length exhibiting separation (SL) in the JCT were measured to calculate the average percent separation length (PSL= SL/TL). Outflow facility increased 149.2% (p<0.01) from baseline after washout during long-duration perfusion, and 114.9% (p=0.004) after Y27 treatment, but did not change significantly after short-duration perfusion in control eyes (p=0

  12. Leptogenesis with TeV Scale WR

    NASA Astrophysics Data System (ADS)

    Gu, Pei-Hong; Mohapatra, Rabindra N.

    2018-04-01

    Successful leptogenesis within the conventional TeV-scale left-right implementation of type-I seesaw has been shown to require that the mass of the right-handed WR± boson should have a lower bound much above the reach of the Large Hadron Collider. This bound arises from the necessity to suppress the washout of lepton asymmetry due to WR±-mediated Δ L ≠0 processes. We show that in an alternative quark seesaw realization of left-right symmetry, the above bound can be avoided. Lepton asymmetry in this model is generated not via the usual right-handed neutrino decay but rather via the decay of new heavy scalars producing an asymmetry in the B -L carrying Higgs triplets responsible for type-II seesaw, whose decay leads to the lepton asymmetry.

  13. PopIII-star siblings in IZw18 and metal-poor WR galaxies unveiled from integral field spectroscopy

    NASA Astrophysics Data System (ADS)

    Kehrig, C.; Vílchez, J. M.; Pérez-Montero, E.; Iglesias-Páramo, J.; Brinchmann, J.; Crowther, P. A.; Durret, F.; Kunth, D.

    Here, we highlight our recent results from the IFS study of Mrk178, the closest metal-poor WR galaxy, and of IZw18, the most metal-poor star-forming galaxy known in the local Universe. The IFS data of Mrk178 show the importance of aperture effects on the search for WR features, and the extent to which physical variations in the ISM properties can be detected. Our IFS data of IZw18 reveal its entire nebular HeIIλ4686-emitting region, and indicate for the very first time that peculiar, hot (nearly) metal-free ionizing stars (called here PopIII-star siblings) might hold the key to the HeII-ionization in IZw18.

  14. Love-type seam-waves in washout models of coal seams

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Breitzke, M.; Dresen, L.

    The propagation of Love seam-waves across washouts of coal seams was studied by calculating synthetic seismograms with a finite-difference method. Seam interruption, seam end and seam thinning models ere investigated. The horizontal offset, the dip of the discontinuities and the degree of erosion served as variable parameters. Maximum displacement amplitudes, relative spectral amplitudes and phase and group slowness curves were extracted from the synthetic seismograms. Both seam interruption and seam thinning reduce the maximum displacement amplitudes of the transmitted Love seam-waves. The degree of amplitude reduction depends on the horizontal offset and the degree of erosion. It is four timesmore » greater for a total seam interruption than for an equivalent seam thinning with a horizontal offset of four times the seam thickness. In a seam cut vertically, the impedance contrast between the coal and the washout filling determines the maximum displacement amplitudes of the reflected Love seam-waves. They diminish by a maximum factor of four in oblique interruption zone discontinuities with a dip of maximum 27/sup 0/, and by a maximum factor of ten in a seam thinning with a degree of erosion of at least 22%.« less

  15. Microcrustacea in flowing water - experimental-analysis of washout times and a field-test

    USGS Publications Warehouse

    Richardson, W.B.

    1992-01-01

    1. Flow-chamber experiments were conducted to evaluate the ability of microcrustacea to maintain position in moving water. These results were compared to distributions of zooplankton and water velocity in a stream pool to determine the relationship of animal density to water movement and swimming ability.^2. Cladocerans exhibited negative rheotaxis (directed behaviour against a current) but poor ability to maintain position at velocities >2.5 Cm s-1. Daphnia and scapholeberis were better at avoiding washout than moina and diaphanosoma. At velocities 2.5 Cm s-1, scapholeberis >3.2 Cm s-1 and eucyclops >7.75 Cm s-1. Washout time of daphnia and scapholeberis was positively related to body size and negatively to water velocity and possession of eggs. Washout was inversely related to water velocity for eucyclops.^4. Highest densities of microcrustacea in a stream pool were found in non-flowing or downstream zones of the pool. Benthic (hydracarina, harpacticoid copepods, ostracods) and fast-swimming (cyclopoids) forms were most common in flowing zones. Facultatively benthic cladocera were abundant in regions of no flow. Rotifers and immature copepods were most abundant at the downstream end of the pool.^5. Behavioural mechanisms for remaining in stream pools at times of high flow appear to include: (i) flow avoidance (simocephalus, chydorus, scapholeberis and cyclopoids), (ii) use of benthic habitat (ostracods, harpacticoids, hydracarina), (iii) strong swimming ability (cyclopoids).

  16. Transmission-blocking activity of tafenoquine (WR-238605) and artelinic acid against naturally circulating strains of Plasmodium vivax in Thailand.

    PubMed

    Ponsa, Narong; Sattabongkot, Jetsumon; Kittayapong, Pattamaporn; Eikarat, Nantana; Coleman, Russell E

    2003-11-01

    The sporontocidal activity of tafenoquine (WR-238605) and artelinic acid was determined against naturally circulating isolates of Plasmodium vivax in western Thailand. Primaquine was used as a negative control and a dihydroacridine-dione (WR-250547) was used as a positive control. Laboratory-reared Anopheles dirus mosquitoes were infected with P. vivax by allowing mosquitoes to feed on blood (placed in an artificial-membrane feeding apparatus) collected from gametocytemic volunteers reporting to local malaria clinics in Tak province, Thailand. Four days post-infection, mosquitoes were refed on uninfected mice treated 90 minutes earlier with a given drug. Drug activity was determined by assessing oocyst and sporozoite development. Neither primaquine nor artelinic acid affected oocyst or sporozoite development at a dose of 100 mg of base drug/kg of mouse body weight. In contrast, tafenoquine and WR-250547 affected sporogonic development at doses as low as 25.0 and 0.39 mg/kg, respectively. The potential role of these compounds in the prevention of malaria transmission is discussed, as are alternative strategies for the use of transmission-blocking antimalarial drugs.

  17. JWST DD ERS Team Update: Decoding Smoke Signals from WR140 using NIRISS+AMI and MIRI/MRS

    NASA Astrophysics Data System (ADS)

    Lau, Ryan M.; Hankins, Matt; WR DustERS Team

    2018-06-01

    Dust is a key component of the interstellar medium and plays and important role in the formation of stars and planets. However, the dominant channels of dust production throughout cosmic time are uncertain. With its unprecedented sensitivity and spatial resolution in the mid-IR, the James Webb Space Telescope (JWST) is the ideal platform to address this issue by investigating the dust abundance, composition, and production rates of various dusty sources. In particular, colliding-wind Wolf-Rayet (WR) binaries are known to be efficient dust producers in the local Universe and likely existed in the earliest galaxies. In our Early Release Science (ERS) program, we will use JWST to observe the archetypal colliding-wind binary, WR 140, to study its dust composition, abundance, and formation mechanisms. We will utilize two key JWST observing modes with the medium-resolution spectrometer (MRS) on the Mid-Infrared Instrument (MIRI) and the Aperture Masking Interferometry (AMI) mode with the Near Infrared Imager and Slitless Spectrograph (NIRISS).Our planned observations will establish a benchmark for key observing modes for imaging bright sources with faint extended emission at high spatial resolutions. This will be valuable in various astrophysical contexts including mass-loss from evolved stars, dusty tori around active galactic nuclei, and protoplanetary disks. We are committed to delivering science-enabling products for the JWST community that include high-level pipeline tools to mitigate bright source artifacts and image reconstruction tools compatible with NIRISS+AMI data.

  18. Novel methodology to perform sulfur hexafluoride (SF6)-based multiple-breath wash-in and washout in infants using current commercially available equipment.

    PubMed

    Gustafsson, P M; Robinson, P D; Lindblad, A; Oberli, D

    2016-11-01

    Multiple-breath inert gas washout (MBW) is ideally suited for early detection and monitoring of serious lung disease, such as cystic fibrosis, in infants and young children. Validated commercial options for the MBW technique are limited, and suitability of nitrogen (N 2 )-based MBW is of concern given the detrimental effect of exposure to pure O 2 on infant breathing pattern. We propose novel methodology using commercially available N 2 MBW equipment to facilitate 4% sulfur hexafluoride (SF 6 ) multiple-breath inert gas wash-in and washout suitable for the infant age range. CO 2 , O 2 , and sidestream molar mass sensor signals were used to accurately calculate SF 6 concentrations. An improved dynamic method for synchronization of gas and respiratory flow was developed to take into account variations in sidestream sample flow during MBW measurement. In vitro validation of triplicate functional residual capacity (FRC) assessments was undertaken under dry ambient conditions using lung models ranging from 90 to 267 ml, with tidal volumes of 28-79 ml, and respiratory rates 20-60 per minute. The relative mean (SD, 95% confidence interval) error of triplicate FRC determinations by washout was -0.26 (1.84, -3.86 to +3.35)% and by wash-in was 0.57 (2.66, -4.66 to +5.79)%. The standard deviations [mean (SD)] of percentage error among FRC triplicates were 1.40 (1.14) and 1.38 (1.32) for washout and wash-in, respectively. The novel methodology presented achieved FRC accuracy as outlined by current MBW consensus recommendations (95% of measurements within 5% accuracy). Further clinical evaluation is required, but this new technique, using existing commercially available equipment, has exciting potential for research and clinical use. Copyright © 2016 the American Physiological Society.

  19. The first orbital solution for the massive colliding-wind binary HD 93162 (≡WR 25)

    NASA Astrophysics Data System (ADS)

    Gamen, R.; Gosset, E.; Morrell, N.; Niemela, V.; Sana, H.; Nazé, Y.; Rauw, G.; Barbá, R.; Solivella, G.

    2006-12-01

    Context: Since the discovery, with the EINSTEIN satellite, of strong X-ray emission associated with HD 93162 (≡WR 25), this object has been predicted to be a colliding-wind binary system. However, radial-velocity variations that would prove the suspected binary nature have yet to be found. Aims: We spectroscopically monitored this object to investigate its possible variability to address this discordance. Methods: We compiled the largest available radial-velocity data set for this star to look for variations that might be due to binary motion. We derived radial velocities from spectroscopic data acquired mainly between 1994 and 2006, and searched these radial velocities for periodicities using different numerical methods. Results: For the first time, periodic radial-velocity variations are detected. Our analysis definitively shows that the Wolf-Rayet star WR 25 is an eccentric binary system with a probable period of about 208 days.

  20. The field experiments on the HTO washout from the atmosphere

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Golubev, A.V.; Mavrin, S.V.; Golubeva, V.N.

    2015-03-15

    HTO (tritiated water) wash-out from the atmosphere is one of the key processes governing the HTO transport from the atmosphere into soil and plants. Experimental studies of the HTO interaction with water drops were carried out both in laboratories and in the field. In the course of experiments, the following rain characteristics were recorded: rain intensity, size distribution of drops, and falling velocities and their dependence on drop diameter. A laser optical device was designed and used to measure the distribution of the drop radius and velocities during the period of experiment. The tritium source was placed at a heightmore » of 30 m. Rainwater samples were collected in plastic bottles and their HTO activity was determined by liquid scintillation techniques. The data obtained for the experimental values of the scavenging rate are within the range from 4.12*10{sup -5} to 1.57*10{sup -4} s{sup -1} and correspond to the precipitation intensity from 0.3 to 1.26 mm/hour. These results are in sufficiently good agreement with the results of earlier papers.« less

  1. [Determination of polioksin B in the air environment and in washouts from skin of operators by HPLC].

    PubMed

    Volkova, V N; Mukhina, L P; Chistova, Zh A; Fedorova, S G

    Polyoxin B being an effective inhibitor of synthesis of chitin of the cell wall of many phytopathogenic fungi, is recommended as a fungicide for control of phytopathogenic organisms that cause damage to crop. For the determination of the exposure of employees working with pesticides there was developed the method of the measurement of concentrations of polyoxin B in air of working area, atmospheric air of populated areas and washouts from the operators ’ integuments, based on high performance liquid chromatography with ultraviolet detector (detection wavelength of270 nm), including sampling air environment in the sorption tube ORBO-44, filled with sorbent XAD-2, extraction of the sorbent with polyoxin by a mixture of carbinol-water (in a ratio of 95:5,on volume), washout from the surface of the skin with ethyl alcohol by way of washing, concentrating, quantitative chromatographic analysis. Lower limits of the quantification ofpolyoxin B in the air ofworking area - 0.2 mg/m at the aspiration of 2 dm of air, atmospheric air - 0.016 mg/m at the aspiration of 25 dm of air, in washouts from the operators’ integuments - 0.4 pg/wash, the linear range of the defined concentrations accounted for of 0.2 - 2.4 pg/cm, the total error of measurement of the concentrations of polyoxin B in air is 17%; in washouts from the operators’ integuments - 16%. The developed method was approbated for the determination of polyoxin in samples of air of working zone, atmospheric air within the sanitary gap, washouts from the operators ’ integuments and air drift samples taken under processing of roses in the hothouse and in the monitoring of the phytosanitary condition of the plants every other day after treatment.

  2. Experimental and calculated characteristics of three wings of NACA 64-210 and 65-210 airfoil sections with and without 2 degree washout

    NASA Technical Reports Server (NTRS)

    Sivells, James C

    1947-01-01

    Report presents the results of an investigation conducted to determine some of the effects of airfoil section and washout on the experimental and calculated characteristics of 10-percent-thick wings. Three wings of aspect ratio 9 and ratio of root chord to tip chord 2.5 were tested. One wing had NACA 64-210 sections and 2 degree washout, the second had NACA 65-210 sections and 2 degree washout, and the third had NACA 65-210 sections and 0 degree washout. It was found that the experimental characteristics of the wings could be satisfactorily predicted from calculations based upon two-dimensional data when the airfoil contours of the wings conformed to the true airfoil sections with the same high degree of accuracy as the two-dimensional models.

  3. Evolution of Planetary Nebulae with WR-type Central Stars

    NASA Astrophysics Data System (ADS)

    Danehkar, Ashkbiz

    2014-04-01

    This thesis presents a study of the kinematics, physical conditions and chemical abundances for a sample of Galactic planetary nebulae (PNe) with Wolf-Rayet (WR) and weak emission-line stars (wels), based on optical integral field unit (IFU) spectroscopy obtained with the Wide Field Spectrograph (WiFeS) on the Australian National University 2.3 telescope at Siding Spring Observatory, and complemented by spectra from the literature. PNe surrounding WR-type stars constitute a particular study class for this study. A considerable fraction of currently well-identified central stars of PNe exhibit 'hydrogen-deficient' fast expanding atmospheres characterized by a large mass-loss rate. Most of them were classified as the carbon-sequence and a few of them as the nitrogen-sequence of the WR-type stars. What are less clear are the physical mechanisms and evolutionary paths that remove the hydrogen-rich outer layer from these degenerate cores, and transform it into a fast stellar wind. The aim of this thesis is to determine kinematic structure, density distribution, thermal structure and elemental abundances for a sample of PNe with different hydrogen-deficient central stars, which might provide clues about the origin and formation of their hydrogen-deficient stellar atmospheres. Hα and [N II] emission features have been used to determine kinematic structures. Based on spatially resolved observations of these emission lines, combined with archival Hubble Space Telescope imaging for compact PNe, morphological structures of these PNe have been determined. Comparing the velocity maps from the IFU spectrograph with those provided by morpho-kinematic models allowed disentangling of the different morphological components of most PNe, apart from the compact objects. The results indicate that these PNe have axisymmetric morphologies, either bipolar or elliptical. In many cases, the associated kinematic maps for PNe around hot WR-type stars also show the presence of so-called fast

  4. Penile blood flow by xenon-133 washout

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Haden, H.T.; Katz, P.G.; Mulligan, T.

    1989-06-01

    Penile erectile failure is often attributed to abnormalities of vascular supply or drainage, but few direct measurements of penile blood flow have been made. We describe the xenon washout method for measurement of penile blood flow, and present the results obtained in a group of normal and impotent subjects. The procedure was performed with standard nuclear imaging equipment. Flaccid-state penile blood flow in the impotent patients studied was not significantly different from the normal group, suggesting that flaccid-state measurements may not be helpful in evaluation of erectile failure. However, this method can be used to measure penile venous outflow withmore » stimulated or induced erection, and may provide a method for detecting abnormal venous leakage.« less

  5. Protection of mice against mixed fission neutron-gamma (n: gamma = 1:1) irradiation by WR-2721, 16,16-dimethyl PGE2, and the combination of both agents

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Steel, L.K.; Walden, T.L. Jr.; Hughes, H.N.

    1988-09-01

    The survival of mice after whole-body exposure to a modified fission neutron-gamma field (n: gamma = 1:1) was used to examine radiation protection by WR-2721, 16,16-dimethyl PGE2(DiPGE2), and the combination of both agents. Administration of WR-2721 (453 mg/kg) increased the LD50/30 from 5.24 to 7.17 Gy (DMF = 1.37), whereas pretreatment with DiPGE2 (1.6 mg/kg) increased the LD50/30 to 5.77 Gy (dose modification factor (DMF) = 1.10). The combination of 453 mg/kg WR-2721 and 0.4 mg/kg DiPGE2 resulted in an LD50/30 of 7.33 Gy, yielding a DMF of 1.39. However, no significant difference in protection was obtained with the combinationmore » of the two agents compared to that seen with WR-2721 alone.« less

  6. Status of rates and rate equations for thermal leptogenesis

    NASA Astrophysics Data System (ADS)

    Biondini, S.; Bödeker, D.; Brambilla, N.; Garny, M.; Ghiglieri, J.; Hohenegger, A.; Laine, M.; Mendizabal, S.; Millington, P.; Salvio, A.; Vairo, A.

    2018-02-01

    In many realizations of leptogenesis, heavy right-handed neutrinos play the main role in the generation of an imbalance between matter and antimatter in the early Universe. Hence, it is relevant to address quantitatively their dynamics in a hot and dense environment by taking into account the various thermal aspects of the problem at hand. The strong washout regime offers an interesting framework to carry out calculations systematically and reduce theoretical uncertainties. Indeed, any matter-antimatter asymmetry generated when the temperature of the hot plasma T exceeds the right-handed neutrino mass scale M is efficiently erased, and one can focus on the temperature window T ≪ M. We review recent progress in the thermal field theoretic derivation of the key ingredients for the leptogenesis mechanism: the right-handed neutrino production rate, the CP asymmetry in the heavy-neutrino decays and the washout rates. The derivation of evolution equations for the heavy-neutrino and lepton-asymmetry number densities, their rigorous formulation and applicability are also discussed.

  7. Enhanced washout of 99mTc-tetrofosmin in hypertrophic cardiomyopathy: quantitative comparisons with regional 123I-BMIPP uptake and wall thickness determined by MRI.

    PubMed

    Thet-Thet-Lwin; Takeda, Tohoru; Wu, Jin; Fumikura, Yuko; Iida, Keiji; Kawano, Satoru; Yamaguchi, Iwao; Itai, Yuji

    2003-07-01

    The diagnostic value of technetium-99m tetrofosmin (TF) washout in hypertrophic cardiomyopathy (HCM) was examined by investigating its relation to the metabolic abnormality depicted by iodine-123 beta-methyl- p-iodophenylpentadecanoic acid (BMIPP) uptake and the left ventricular (LV) myocardial wall thickness as measured by magnetic resonance imaging (MRI). TF washout was evaluated in 31 patients with HCM and 23 normal control subjects using 30-min (early) and 3-h (delayed) TF single-photon emission tomography images. The LV myocardial wall was divided into 19 segments and the percentage TF washout, regional BMIPP uptake and LV wall thickness were measured in each segment. Mean TF washout in the patients with HCM was significantly faster than that in normal control subjects (23.7+/-5.7 vs 13.4+/-4.1, P<0.0001). In the patients with HCM, TF washout showed an excellent correlation with MRI wall thickness ( r=0.82, P<0.0001) and a good inverse correlation with regional BMIPP uptake ( r=-0.72, P<0.0001). In addition, a good linear correlation was observed between TF uptake and MRI wall thickness in the 19 regional segments. In conclusion, the degree of TF washout corresponds well with the severity of myocardial wall thickness and the degree of metabolic abnormality in patients with HCM. These results suggest that enhanced TF washout might provide additional clinical information regarding metabolic alterations in HCM.

  8. Hydrodynamical simulations of Pinwheel nebula WR 104

    NASA Astrophysics Data System (ADS)

    Lamberts, A.; Fromang, S.; Dubus, G.

    2010-12-01

    The interaction of stellar winds from two companion stars leads to the formation of a shocked structure. Several analytic solutions have been developped to model this phenomenon. We compare our 2D and 3D hydrodynamical simulations to these results and highlight their shortcomings. Analytic solutions do not take orbital motion into account although this drastically changes the structure at large distances, turning it into a spiral. This is observed in Pinwheel Nebulae, binaries composed of a Wolf-Rayet star and an early-type star. Their infrared emission is due to dust whose origin is stil poorly constrained. We perform large scale 2D simulations of one particular system, WR 104. Including the orbital motion, we follow the flow up to a few steps of the spiral. This is made possible using adaptive mesh refinement. We determine the properties of the gas in the winds and confirm the flow in the spiral has a ballistic motion.

  9. Measurement of tafenoquine (WR 238605) in human plasma and venous and capillary blood by high-pressure liquid chromatography.

    PubMed

    Kocisko, D A; Walsh, D S; Eamsila, C; Edstein, M D

    2000-04-01

    A simple, rapid, and accurate high-pressure liquid chromatographic method with fluorescence detection is described for the measurement of tafenoquine (TQ) (also known as WR 238605) from human plasma and venous and capillary blood. Tafenoquine was measured in plasma and venous blood following protein precipitation. Chromatographic separation was achieved using a Waters S5P Spherisorb phenyl analytical cartridge (150 mm x 4.6 mm I.D., 5 microm particle size) (Waters, Milford, MA, USA) and a mobile phase of 22 mM ammonium acetate, pH 4:acetonitrile (45:55, vol/vol). The flow rate was 1.5 mL/min and the retention times were approximately 3.5 min for WR VIIIAc (internal standard) and approximately 7.8 min for TQ. The interday and intraday coefficients of variation of TQ over a concentration range of 20-1000 ng/mL in plasma were < or =8.4% and in venous blood were < or =9.6%. The mean percent difference between added concentration and obtained concentration was 7.3% in plasma and 8.5% in venous blood over the corresponding concentration range. The limit of quantitation for both fluids was 10 ng/mL. Tafenoquine concentrations were comparable between capillary and venous blood with no significant difference between measurement in both biological fluids. The clinical application of the method was demonstrated by measuring plasma and whole blood concentrations of TQ from participants in a chemosuppression trial of the drug against malaria infections in Thailand.

  10. Blood schizontocidal activity of WR 238605 (Tafenoquine) against Plasmodium cynomolgi and Plasmodium fragile infections in rhesus monkeys.

    PubMed

    Puri, S K; Dutta, G P

    2003-04-01

    A new 8-aminoquinoline antimalarial WR 238605 (Tafenoquine), developed initially as a primaquine alternative for prevention of Plasmodium vivax relapses was evaluated for blood schizontocidal activity against two simian malaria infections namely Plasmodium cynomolgi B and Plasmodium fragile in rhesus monkeys. Treatment with WR 238605 at a dose of 3.16 mg(base)/kg/day x 7 days cured established trophozoite induced infections in monkeys with both these parasites. The lower dose of 1.00 mg/kg/day cured 9 out of 12 monkeys infected with P. cynomolgi B and 10 out of 11 monkeys infected with P. fragile. Primaquine was only partially curative at 10.0 mg(base)/kg/day x 7 dose regimen against both these infections. The potent blood schizontocidal activity of tafenoquine adds to the armoury of antimalarial drugs.

  11. Hepatocellular carcinoma in cirrhotic patients at multidetector CT: hepatic venous phase versus delayed phase for the detection of tumour washout

    PubMed Central

    Furlan, A; Marin, D; Vanzulli, A; Patera, G Palermo; Ronzoni, A; Midiri, M; Bazzocchi, M; Lagalla, R; Brancatelli, G

    2011-01-01

    Objectives Our aim was to compare retrospectively hepatic venous and delayed phase images for the detection of tumour washout during multiphasic multidetector row CT (MDCT) of the liver in patients with hepatocellular carcinoma (HCC). Methods 30 cirrhotic patients underwent multiphasic MDCT in the 90 days before liver transplantation. MDCT was performed before contrast medium administration and during hepatic arterial hepatic venous and delayed phases, images were obtained at 12, 55 and 120 s after trigger threshold. Two radiologists qualitatively evaluated images for lesion attenuation. Tumour washout was evaluated subjectively and objectively. Tumour-to-liver contrast (TLC) was measured for all pathologically proven HCCs. Results 48 HCCs were detected at MDCT. 46 of the 48 tumours (96%) appeared as either hyper- or isoattenuating during the hepatic arterial phase subjective washout was present in 15 HCCs (33%) during the hepatic venous phase and in 35 (76%) during the delayed phase (p<0.001, McNemar’s test). Objective washout was present in 30 of the 46 HCCs (65%) during the hepatic venous phase and in 42 of the HCCs (91%) during the delayed phase (p=0.001). The delayed phase yielded significantly higher mean TLC absolute values compared with the hepatic venous phase (−16.1±10.8 HU vs −10.5±10.2 HU; p<0.001). Conclusions The delayed phase is superior to the hepatic venous phase for detection of tumour washout of pathologically proven HCC in cirrhotic patients. PMID:21081569

  12. Determination of the radioprotective effects of topical applications of MEA, WR-2721, and N-acetylcysteine on murine skin

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Verhey, L.J.; Sedlacek, R.

    1983-01-01

    Topical applications of MEA (beta-mercaptoethylamine or cysteamine), WR-2721 (S-2-(3-aminopropylamino)-ethylphosphorothioic acid), and N-acetylcysteine (NAC) were tested for their ability to protect the normal skin of the hind legs of mice against acute and late damage from single doses of /sup 137/Cs radiation. No significant protection was observed with either WR-2721 or NAC. MEA was shown to offer significant protection against acute skin damage in both buffered and unbuffered forms, but no significant protection against late contraction. The use of topical MEA on unanesthetized animals breathing carbogen (95% O2, 5% CO2) appears to give an enhanced level of radioprotection over that shownmore » for anesthetized, air-breathing animals.« less

  13. Emptying patterns of the lung studied by multiple-breath N2 washout

    NASA Technical Reports Server (NTRS)

    Lewis, S. M.

    1978-01-01

    Changes in the nitrogen concentration seen during the single-breath nitrogen washout reflect changes in relative flow (ventilation) from units with differing ventilation/volume ratios. The multiple-breath washout provides sufficient data on ventilation for units with varying ventilation/volume ratios to be plotted as a function of the volume expired. Flow from the dead space may also be determined. In young normals the emptying patterns are narrow and unimodal throughout the alveolar plateau with little or no flow from the dead space at the end of the breath. Older normals show more flow from the dead space, particularly toward the end of the breath, and some show a high ventilation/volume ratio mode early in the breath. Patients with obstructive lung disease have a high flow from the dead space which is present throughout the breath. A well ventilated mode at the end of the breath is seen in some obstructed subjects. Patients with cystic fibrosis showed a poorly ventilated mode appearing at the end of the breath as well as a very high dead space.

  14. Bacterial Selection during the Formation of Early-Stage Aerobic Granules in Wastewater Treatment Systems Operated Under Wash-Out Dynamics

    PubMed Central

    Weissbrodt, David G.; Lochmatter, Samuel; Ebrahimi, Sirous; Rossi, Pierre; Maillard, Julien; Holliger, Christof

    2012-01-01

    Aerobic granular sludge is attractive for high-rate biological wastewater treatment. Biomass wash-out conditions stimulate the formation of aerobic granules. Deteriorated performances in biomass settling and nutrient removal during start-up have however often been reported. The effect of wash-out dynamics was investigated on bacterial selection, biomass settling behavior, and metabolic activities during the formation of early-stage granules from activated sludge of two wastewater treatment plants (WWTP) over start-up periods of maximum 60 days. Five bubble-column sequencing batch reactors were operated with feast-famine regimes consisting of rapid pulse or slow anaerobic feeding followed by aerobic starvation. Slow-settling fluffy granules were formed when an insufficient superficial air velocity (SAV; 1.8 cm s−1) was applied, when the inoculation sludge was taken from a WWTP removing organic matter only, or when reactors were operated at 30°C. Fast-settling dense granules were obtained with 4.0 cm s−1 SAV, or when the inoculation sludge was taken from a WWTP removing all nutrients biologically. However, only carbon was aerobically removed during start-up. Fluffy granules and dense granules were displaying distinct predominant phylotypes, namely filamentous Burkholderiales affiliates and Zoogloea relatives, respectively. The latter were predominant in dense granules independently from the feeding regime. A combination of insufficient solid retention time and of leakage of acetate into the aeration phase during intensive biomass wash-out was the cause for the proliferation of Zoogloea spp. in dense granules, and for the deterioration of BNR performances. It is however not certain that Zoogloea-like organisms are essential in granule formation. Optimal operation conditions should be elucidated for maintaining a balance between organisms with granulation propensity and nutrient removing organisms in order to form granules with BNR activities in short

  15. Bacterial Selection during the Formation of Early-Stage Aerobic Granules in Wastewater Treatment Systems Operated Under Wash-Out Dynamics.

    PubMed

    Weissbrodt, David G; Lochmatter, Samuel; Ebrahimi, Sirous; Rossi, Pierre; Maillard, Julien; Holliger, Christof

    2012-01-01

    Aerobic granular sludge is attractive for high-rate biological wastewater treatment. Biomass wash-out conditions stimulate the formation of aerobic granules. Deteriorated performances in biomass settling and nutrient removal during start-up have however often been reported. The effect of wash-out dynamics was investigated on bacterial selection, biomass settling behavior, and metabolic activities during the formation of early-stage granules from activated sludge of two wastewater treatment plants (WWTP) over start-up periods of maximum 60 days. Five bubble-column sequencing batch reactors were operated with feast-famine regimes consisting of rapid pulse or slow anaerobic feeding followed by aerobic starvation. Slow-settling fluffy granules were formed when an insufficient superficial air velocity (SAV; 1.8 cm s(-1)) was applied, when the inoculation sludge was taken from a WWTP removing organic matter only, or when reactors were operated at 30°C. Fast-settling dense granules were obtained with 4.0 cm s(-1) SAV, or when the inoculation sludge was taken from a WWTP removing all nutrients biologically. However, only carbon was aerobically removed during start-up. Fluffy granules and dense granules were displaying distinct predominant phylotypes, namely filamentous Burkholderiales affiliates and Zoogloea relatives, respectively. The latter were predominant in dense granules independently from the feeding regime. A combination of insufficient solid retention time and of leakage of acetate into the aeration phase during intensive biomass wash-out was the cause for the proliferation of Zoogloea spp. in dense granules, and for the deterioration of BNR performances. It is however not certain that Zoogloea-like organisms are essential in granule formation. Optimal operation conditions should be elucidated for maintaining a balance between organisms with granulation propensity and nutrient removing organisms in order to form granules with BNR activities in short

  16. Roll tracking effects of G-vector tilt and various types of motion washout

    NASA Technical Reports Server (NTRS)

    Jex, H. R.; Magdaleno, R. E.; Junker, A. M.

    1978-01-01

    In a dogfight scenario, the task was to follow the target's roll angle while suppressing gust disturbances. All subjects adopted the same behavioral strategies in following the target while suppressing the gusts, and the MFP-fitted math model response was generally within one data symbol width. The results include the following: (1) comparisons of full roll motion (both with and without the spurious gravity tilt cue) with the static case. These motion cues help suppress disturbances with little net effect on the visual performance. Tilt cues were clearly used by the pilots but gave only small improvement in tracking errors. (2) The optimum washout (in terms of performance close to real world, similar behavioral parameters, significant motion attenuation (60 percent), and acceptable motion fidelity) was the combined attenuation and first-order washout. (3) Various trends in parameters across the motion conditions were apparent, and are discussed with respect to a comprehensive model for predicting adaptation to various roll motion cues.

  17. Spatially resolved spectroscopy of WR ring nebulae. I - NGC 2359 and RCW 78

    NASA Astrophysics Data System (ADS)

    Esteban, C.; Vilchez, J. M.; Manchado, A.; Edmunds, M. G.

    1990-01-01

    We report detailed spatially resolved spectroscopy of the WR nebulae NGC 2359 and RCW 78 surrounding the WN 5 HD 56925 and WN 8 HD 117688 stars. The aim of this work has been to study possible abundance inhomogeneities and the ionization structure of the nebulae, as well as to derive reliable values for the degree of self-enrichment. In NGC 2359 the derived ratio O2+/O+ shows localized variations resulting from the compression of the gas in the filaments with respect to the shell gas. Effective temperatures for the central stars of both nebulae have been estimated on the basis of the ionization structure; the values found appear appropriate for their spectral types. Abundances of O/H, NIH, Ne/H, and He/H have been determined in twelve different positions in NGC 2359, covering its different morphological zones. No significant differences in the N/H and O/H abundances across the nebula have been found, although He/H shows marginal evidence for localized enhancements. In the case of RCW 78 the derived value of O/H is roughly solar, but He/H and NIH may be slightly overabundant. The results suggest that the amount of chemical self-enrichment of these WR nebulae is, at most, small.

  18. Hypolipidemic effect of MeOH extract of Bambusae Caulis in Taeniam in hyperlipidemia induced by Triton WR-1339 and high cholesterol diet in rats.

    PubMed

    Ham, Inhye; Yang, Gabsik; Lee, Jaejun; Lee, Kyung-Jin; Choi, Ho-Young

    2009-01-01

    Hyperlipidemia has been implicated in atherosclerosis which is the leading cause of death among world population and resulting from lipid metabolic changes is a major cause of atherosclerosis. Bambusae Caulis in Taeniam belongs to Bambusaceae is the stem of Phyllostachys nigra (Lodd.) Munro var. henonis (Bean) Stapf of Phyllostachys bambusoides Siebold et Zuccarini, the perennial evergreen tree. The green middle layer of stem is dried in string-shape I shadow after the bark had been removed. In this study, the effects of middle layer of PN, PB, PP, and BCT on rat with hyperlipidemia, induced by Triton WR-1339 and high cholesterol diet were investigated. We measured plasma levels of triglyceride, total cholesterol, low-density lipoprotein (LDL)-cholesterol, and high-density lipoprotein (HDL)-cholesterol as measure of its hyperlipidemic effects. As a result, all of the Bambusae Caulis in Taeniam was reduced total cholesterol, LDL. Inhibition rate on LDL-oxidation, hACAT-1, and hACAT-2 was increased dose-dependently. Therefore all of the Bambusae Caulis in Taeniam is a good candidate for the treatment on Triton WR-1339 and high cholesterol diet-induced blood circulatory disorders, obesity, and hyperlipidemia.

  19. Randomized dose-ranging study of the safety and efficacy of WR 238605 (Tafenoquine) in the prevention of relapse of Plasmodium vivax malaria in Thailand.

    PubMed

    Walsh, D S; Looareesuwan, S; Wilairatana, P; Heppner, D G; Tang, D B; Brewer, T G; Chokejindachai, W; Viriyavejakul, P; Kyle, D E; Milhous, W K; Schuster, B G; Horton, J; Braitman, D J; Brueckner, R P

    1999-10-01

    WR 238605 is an 8-aminoquinoline developed for the radical cure of Plasmodium vivax. Forty-four P. vivax-infected patients were randomly assigned to 1 of 4 treatment regimens: 3 groups received a blood schizonticidal dose of chloroquine followed by WR 238605: group A (n=15) received 300 mg daily for 7 days; group B (n=11), 500 mg daily for 3 days, repeated 1 week after the initial dose; group C (n=9), 1 dose of 500 mg. A fourth group (D; n=9) received chloroquine only. Among patients who completed 2-6 months of follow-up (n=23), there was 1 relapse in group B (day 120) and 1 in group C (day 112). Among patients treated with chloroquine only, there were 4 relapses (days 40, 43, 49, and 84). WR 238605 was safe, well tolerated, and effective in preventing P. vivax relapse.

  20. Multiwavelength observations of NaSt1 (WR 122): equatorial mass loss and X-rays from an interacting Wolf-Rayet binary

    NASA Astrophysics Data System (ADS)

    Mauerhan, Jon; Smith, Nathan; Van Dyk, Schuyler D.; Morzinski, Katie M.; Close, Laird M.; Hinz, Philip M.; Males, Jared R.; Rodigas, Timothy J.

    2015-07-01

    NaSt1 (aka Wolf-Rayet 122) is a peculiar emission-line star embedded in an extended nebula of [N II] emission with a compact dusty core. The object was previously characterized as a Wolf-Rayet (WR) star cloaked in an opaque nebula of CNO-processed material, perhaps analogous to η Car and its Homunculus nebula, albeit with a hotter central source. To discern the morphology of the [N II] nebula we performed narrow-band imaging using the Hubble Space Telescope and Wide-field Camera 3. The images reveal that the nebula has a disc-like geometry tilted ≈12° from edge-on, composed of a bright central ellipsoid surrounded by a larger clumpy ring. Ground-based spectroscopy reveals radial velocity structure (±10 km s-1) near the outer portions of the nebula's major axis, which is likely to be the imprint of outflowing gas. Near-infrared adaptive-optics imaging with Magellan AO has resolved a compact ellipsoid of Ks-band emission aligned with the larger [N II] nebula, which we suspect is the result of scattered He I line emission (λ2.06 μm). Observations with the Chandra X-ray Observatory have revealed an X-ray point source at the core of the nebula that is heavily absorbed at energies <1 keV and has properties consistent with WR stars and colliding-wind binaries. We suggest that NaSt1 is a WR binary embedded in an equatorial outflow that formed as the result of non-conservative mass transfer. NaSt1 thus appears to be a rare and important example of a stripped-envelope WR forming through binary interaction, caught in the brief Roche lobe overflow phase.

  1. Free thyroxine in needle washout after fine needle aspiration biopsy of toxic thyroid nodules.

    PubMed

    Raikov, Nikolai; Nonchev, Boyan; Chaushev, Borislav; Vjagova, Diyana; Todorov, Svetoslav; Bocheva, Yana; Malceva, Daniela; Vicheva, Snejinka; Raikova, Asyia; Argatska, Antoaneta; Raikov, Miroslav

    2016-01-01

    The main diagnostic tool for toxic adenomas (TA) is radionuclide imaging indicated in patients with evidence of thyroid nodules in combination with thyrotoxic syndrome. Thyroid ultrasound and fine-needle aspiration biopsy (FNAB) are widely used for the valuation of thyroid masses. There is no literature data concerning the utility of FNAB and related tests for the diagnosis of hyperfunctioning thyroid nodules. The purpose of this study is to determine the levels of free thyroxine (FT4) in the needle washout after FNAB of hot thyroid nodules. The results of our study show that the FT4 levels in needle washout from TA were significantly higher than the surrounding parenchyma and correlated with the hormonal changes in patients with thyroid hyperfunctioning nodules. Further studies on a large number of patients are needed to refine the diagnostic value of this method and evaluate its importance in quantitative risk assessment of thyroid autonomy.

  2. WR279,396, a Third Generation Aminoglycoside Ointment for the Treatment of Leishmania major Cutaneous Leishmaniasis: A Phase 2, Randomized, Double Blind, Placebo Controlled Study

    PubMed Central

    Morizot, Gloria; Ben Massoud, Nathalie; Zâatour, Amor; Ben Alaya, Nissaf; Haj Hamida, Nabil Bel; Ahmadi, Zaher El; Downs, Matthew T.; Smith, Philip L.; Dellagi, Koussay; Grögl, Max

    2009-01-01

    Background Cutaneous leishmaniasis (CL) is a disfiguring disease that confronts clinicians with a quandary: leave patients untreated or engage in a complex or toxic treatment. Topical treatment of CL offers a practical and safe option. Accordingly, the treatment of CL with WR279,396, a formulation of paromomycin and gentamicin in a hydrophilic base, was investigated in a phase 2 clinical study in Tunisia and France. Methods A phase 2, randomized, double blind, vehicle-controlled study was conducted to assess the safety and efficacy of topical WR279,396 when applied twice a day for 20 days as treatment for parasitologically confirmed CL. The study protocol established the primary efficacy end point as complete clinical response (CCR) defined as 50% or greater reduction in the ulceration size of an index lesion by day 50 (D50) followed by complete re-epithelialization by D100, and no relapse through D180. Results Ninety-two subjects were randomized. Leishmania major was identified in 66 of 68 isolates typed (97%). In the intent-to-treat population, 47 of 50 WR279,396 treated participants (94%) met the definition of CCR, compared with 30 of 42 vehicle-placebo participants (71%) [p = 0.0045]. Erythema occurred in 30% and 24% of participants receiving WR279,396 and placebo, respectively [p = 0.64]. There was no clinical or laboratory evidence of systemic toxicity. Conclusion Application of WR279,396 for 20 days was found to be safe and effective in treating L. major CL, and offers great potential as a new, simple, easily applicable, and inexpensive topical therapy for this neglected disease. Trial Registration ClinicalTrials.gov NCT00703924 PMID:19415122

  3. A kinesthetic washout filter for force-feedback rendering.

    PubMed

    Danieau, Fabien; Lecuyer, Anatole; Guillotel, Philippe; Fleureau, Julien; Mollet, Nicolas; Christie, Marc

    2015-01-01

    Today haptic feedback can be designed and associated to audiovisual content (haptic-audiovisuals or HAV). Although there are multiple means to create individual haptic effects, the issue of how to properly adapt such effects on force-feedback devices has not been addressed and is mostly a manual endeavor. We propose a new approach for the haptic rendering of HAV, based on a washout filter for force-feedback devices. A body model and an inverse kinematics algorithm simulate the user's kinesthetic perception. Then, the haptic rendering is adapted in order to handle transitions between haptic effects and to optimize the amplitude of effects regarding the device capabilities. Results of a user study show that this new haptic rendering can successfully improve the HAV experience.

  4. Four Week Oral Toxicity Study of WR242511 in Dogs. Volume 2

    DTIC Science & Technology

    1994-06-03

    10^6/cmm Erythrocytes 0.00 NO 6.00 6.00 8.00 8.00 2. HGB g/dL Hemoglobin 0.0 NO 12.0 12.0 19.0 19.0 3. HCT % Hematocrit 0.0 NO 35.0 35.0...IS/ UU CAJ U INDIVIDUAL ANIMAL HEMATOLOGY REPORT BY GROUP TEST : Erythrocytes STUDY ID: 134 SEX: MALE STUDY NO: 134 • ABBR...FOUR WEEK ORAL TOXICITY STUDY OF WR242511 IN DOGS DRAFT INDIVIDUAL ANIMAL HEMATOLOGY REPORT BY GROUP TEST: Erythrocytes STUDY ID: 134 STUDY NO

  5. Measurement of lung volume in mechanically ventilated monkeys with an ultrasonic flow meter and the nitrogen washout method.

    PubMed

    Schibler, Andreas; Hammer, Jürg; Isler, Ruedi; Buess, Christian; Newth, Christopher J L

    2004-01-01

    Measurement of functional residual capacity (FRC) during mechanical ventilation is important to standardise respiratory system compliance and adjust the ventilator settings to optimise lung recruitment. In the present study we compared three methods to measure FRC. The bias flow nitrogen washout technique (FRC(N2MC)), the multiple breath nitrogen washout (FRC(MBNW)) and the multiple breath sulphur-hexafluoride washout using the molar mass signal of an ultrasonic flow meter (FRC(MBSF6)) were compared in six adult monkeys after endotracheal intubation and during spontaneous breathing and mechanical ventilation at three different positive end-expiratory pressure (PEEP) levels of 0, 5 and 10 cmH2O. Animal research laboratory. We found good agreement between all three methods and they all accurately measured changes in FRC when PEEP was increased. The coefficients of variance of the three measurement techniques were in the same range (1.3-9.2%). The measurement of the tracer gas concentration with the molar mass signal of the ultrasonic flow meter provides a good and simple alternative to respiratory mass spectrometer for FRC measurements in ventilated subjects.

  6. Using the orbiting companion to trace WR wind structures in the 29d WC8d + O8-9IV binary CV Ser

    NASA Astrophysics Data System (ADS)

    David-Uraz, Alexandre; Moffat, Anthony F. J.

    2011-07-01

    We have used continuous, high-precision, broadband visible photometry from the MOST satellite to trace wind structures in the WR component of CV Ser over more than a full orbit. Most of the small-scale light-curve variations are likely due to extinction by clumps along the line of sight to the O companion as it orbits and shines through varying columns of the WR wind. Parallel optical spectroscopy from the Mont Megantic Observatory is used to refine the orbital and wind-collision parameters, as well as to reveal line emission from clumps.

  7. Survival of irradiated mice treated with WR-151327, synthetic trehalose dicorynomycolate, or ofloxacin

    NASA Astrophysics Data System (ADS)

    Ledney, G. D.; Elliott, T. B.; Landauer, M. R.; Vigneulle, R. M.; Henderson, P. L.; Harding, R. A.; Tom, S. P.

    1994-10-01

    Spaceflight personnel need treatment options that would enhance survival from radiation and would not disrupt task performance. Doses of prophylactic or therapeutic agents known to induce significant short-term (30-day) survival with minimal behavioral (locomotor) changes were used for 180-day survival studies. In protection studies, groups of mice were treated with the phosphorothioate WR-151327 (200 mg/kg, 25% of the LD10) or the immunomodulator, synthetic trehalose dicorynomycolate (S-TDCM; 8 mg/kg), before lethal irradiation with reactor-generated fission neutrons and γ-rays (n/γ = 1) or 60Co γ-rays. In therapy studies, groups of mice received either S-TDCM, the antimicrobial ofloxacin, or S-TDCM plus ofloxacin after irradiation. For WR-151327 treated-mice, survival at 180 days for n/γ = 1 and γ-irradiated mice was 90% and 92%, respectively; for S-TDCM (protection), 57% and 78%, respectively; for S-TDCM (therapy), 20% and 25%, respectively; for ofloxacin, 38% and 5%, respectively; for S-TDCM combined with ofloxacin, 30% and 30%, respectively; and for saline, 8% and 5%, respectively. Ofloxacin or combined ofloxacin and S-TDCM increased survival from the gram-negative bacterial sepsis that predominated in n/γ = 1) irradiated mice. The efficacies of the treatments depended on radiation quality, treatment agent and its mode of use, and microflora of the host.

  8. Sustainability of a Compartmentalized Host-Parasite Replicator System under Periodic Washout-Mixing Cycles

    PubMed Central

    Furubayashi, Taro

    2018-01-01

    The emergence and dominance of parasitic replicators are among the major hurdles for the proliferation of primitive replicators. Compartmentalization of replicators is proposed to relieve the parasite dominance; however, it remains unclear under what conditions simple compartmentalization uncoupled with internal reaction secures the long-term survival of a population of primitive replicators against incessant parasite emergence. Here, we investigate the sustainability of a compartmentalized host-parasite replicator (CHPR) system undergoing periodic washout-mixing cycles, by constructing a mathematical model and performing extensive simulations. We describe sustainable landscapes of the CHPR system in the parameter space and elucidate the mechanism of phase transitions between sustainable and extinct regions. Our findings revealed that a large population size of compartments, a high mixing intensity, and a modest amount of nutrients are important factors for the robust survival of replicators. We also found two distinctive sustainable phases with different mixing intensities. These results suggest that a population of simple host–parasite replicators assumed before the origin of life can be sustained by a simple compartmentalization with periodic washout-mixing processes. PMID:29373536

  9. The significance of 123I-BMIPP delayed scintigraphic imaging in cardiac patients.

    PubMed

    Akashi, Yoshihiro J; Kida, Keisuke; Suzuki, Kae; Inoue, Koji; Kawasaki, Kensuke; Yamauchi, Masahiro; Musha, Haruki; Anker, Stefan D

    2007-04-25

    Earlier studies have not fully investigated the significance of radionuclide planar imaging in cardiac patients using the fatty acid analogue 123I-beta-methyl-iodophenylpentadecanoic acid (123I-BMIPP). This study was to clarify the effectiveness of 123I-BMIPP in assessing the heart-to-mediastinum ratio (H/M) and myocardial washout rate (WR) in patients with heart disease. Myocardial 123I-BMIPP imaging was performed in 33 patients (20 with chronic heart failure [CHF] and 13 with stable angina pectoris [AP]) and 11 control subjects. Myocardial 123I-BMIPP planner images were obtained 30 min (early image) and 4 h (delayed image) after tracer injection. The left ventricular ejection fraction (LVEF) was measured by quantitative gated single photon emission computed tomography. The concentration of plasma brain natriuretic peptide (BNP) was measured before the scintigraphic study. (1) Delayed H/M was much lower in CHF than in AP (1.93 +/- 0.37 vs. 2.21 +/- 0.38, p < 0.05) and controls (vs. 2.47 +/- 0.38, p < 0.001). (2) The WR in CHF and AP were higher than the WR in controls (39.8 +/- 12.7% and 38.7 +/- 11.1 vs. 27.9 +/- 10.2%, p < 0.01 and p < 0.05, respectively). (3) In all subjects, LVEF was correlated with delayed H/M (r = 0.39, p < 0.01). And, the BNP was correlated with both the WR (r = 0.36, p < 0.05) and delayed H/M (r = - 0.29, p = 0.05). These data strongly suggest that the delayed H/M and myocardial WR of 123I-BMIPP enhances the assessment of the myocardial fatty acid metabolism disorders in patients with heart disease in both masked and unmasked conditions.

  10. Six Month Oral Toxicity Study of WR238605 Succinate in Rats. Volume 1

    DTIC Science & Technology

    1996-02-02

    expressed on the basis of mg base/kg/day. Statistical analyses was performed on an IBM • compatible computer using the commercially available LabCat... iTP (F) tA/G *BUN tTBA(M/F?) Hematology1 NE *RBC(F) iHCT(F) *HGB(F) tMETHGB *PLT(M) i RBC...1 A-2 Part 1: Identity, Purity and Stability of Neat WR238605 Succinate 0bjttaTO IBM ! The objective of this study was to confirm the identity and

  11. Alternatives for reducing relapse rate when switching from natalizumab to fingolimod in multiple sclerosis.

    PubMed

    Fragoso, Yara Dadalti; Adoni, Tarso; Alves-Leon, Soniza Vieira; Apostolos-Pereira, Samira Luisa; Araujo, Yuna Ribeiro de; Becker, Jefferson; Brooks, Joseph Bruno Bidin; Correa, Eber Castro; Damasceno, Alfredo; Damasceno, Carlos Augusto de Albuquerque; Ferreira, Maria Lucia B; Gama, Paulo Diniz da; Gama, Rodrigo Assad Diniz da; Gomes, Sidney; Goncalves, Marcus Vinicius Magno; Grzesiuk, Anderson Kuntz; Machado, Suzana Costa Nunes; Matta, Andre Palma da Cunha; Mendes, Maria Fernanda; Ribeiro, Taysa Alexandrino Goncalves Jube; Rocha, Cristiane Franklin da; Ruocco, Heloisa Helena; Sato, Henry; Simm, Renata Faria; Tauil, Carlos Bernardo; Vasconcelos, Claudia Cristina Ferreira; Vieira, Vera Lucia Ferreira

    2016-02-21

    Natalizumab is a therapeutic option for treating multiple sclerosis (MS) and is particularly efficacious for patients with highly active disease. A long washout period has been recommended between withdrawal of natalizumab and start of fingolimod (another option for treating MS). This long washout period has been associated with a significant increase in MS activity. In the present study, a group of 96 patients who were switched from natalizumab to fingolimod had short washout periods between drugs, or monthly corticosteroid pulse therapy if longer washout periods were recommended. This therapeutic approach led to the lowest reported relapse rate so far, among patients with MS switching from natalizumab to fingolimod (8.3%). No complications from short withdrawal were observed in this group of patients.

  12. Understanding the Unusual X-Ray Emission Properties of the Massive, Close Binary WR 20a: A High Energy Window into the Stellar Wind Initiation Region

    NASA Astrophysics Data System (ADS)

    Montes, Gabriela; Ramirez-Ruiz, Enrico; De Colle, Fabio; Strickler, Rachel

    2013-11-01

    The problem of explaining the X-ray emission properties of the massive, close binary WR 20a is discussed. Located near the cluster core of Westerlund 2, WR 20a is composed of two nearly identical Wolf-Rayet stars of 82 and 83 solar masses orbiting with a period of only 3.7 days. Although Chandra observations were taken during the secondary optical eclipse, the X-ray light curve shows no signs of a flux decrement. In fact, WR 20a appears slightly more X-ray luminous and softer during the optical eclipse, opposite to what has been observed in other binary systems. To aid in our interpretation of the data, we compare with the results of hydrodynamical simulations using the adaptive mesh refinement code Mezcal which includes radiative cooling and a radiative acceleration force term. It is shown that the X-ray emission can be successfully explained in models where the wind-wind collision interface in this system occurs while the outflowing material is still being accelerated. Consequently, WR 20a serves as a critical test-case for how radiatively driven stellar winds are initiated and how they interact. Our models not only procure a robust description of current Chandra data, which cover the orbital phases between 0.3 and 0.6, but also provide detailed predictions over the entire orbit.

  13. Anomalous cosmic ray fluxes in diffusive shock acceleration processes in the heliosphere and in planetary and WR-nebulae

    NASA Astrophysics Data System (ADS)

    Yeghikyan, Ararat

    2018-04-01

    Based on the analogy between interacting stellar winds of planetary nebulae and WR-nebulae, on the one hand, and the heliosphere and the expanding envelopes of supernovae, on the other, an attempt is made to calculate the differential intensity of the energetic protons accelerated to energies of 100 MeV by the shock wave. The proposed one-parameter formula for estimating the intensity at 1-100 MeV, when applied to the heliosphere, shows good agreement with the Voyager-1 data, to within a factor of less than 2. The same estimate for planetary (and WR-) nebulae yields a value 7-8 (3-4) orders of magnitude higher than the mean galactic intensity value. The obtained estimate of the intensity of energetic protons in mentioned kinds of nebulae was used to estimate the doses of irradiation of certain substances, in order to show that such accelerated particles play an important role in radiation-chemical transformations in such nebulae.

  14. Utility of Intermediate-Delay Washout CT Images for Differentiation of Malignant and Benign Adrenal Lesions: A Multivariate Analysis.

    PubMed

    Ng, Chaan S; Altinmakas, Emre; Wei, Wei; Ghosh, Payel; Li, Xiao; Grubbs, Elizabeth G; Perrier, Nancy D; Lee, Jeffrey E; Prieto, Victor G; Hobbs, Brian P

    2018-06-27

    The objective of this study was to identify features that impact the diagnostic performance of intermediate-delay washout CT for distinguishing malignant from benign adrenal lesions. This retrospective study evaluated 127 pathologically proven adrenal lesions (82 malignant, 45 benign) in 126 patients who had undergone portal venous phase and intermediate-delay washout CT (1-3 minutes after portal venous phase) with or without unenhanced images. Unenhanced images were available for 103 lesions. Quantitatively, lesion CT attenuation on unenhanced (UA) and delayed (DL) images, absolute and relative percentage of enhancement washout (APEW and RPEW, respectively), descriptive CT features (lesion size, margin characteristics, heterogeneity or homogeneity, fat, calcification), patient demographics, and medical history were evaluated for association with lesion status using multiple logistic regression with stepwise model selection. Area under the ROC curve (A z ) was calculated from both univariate and multivariate analyses. The predictive diagnostic performance of multivariate evaluations was ascertained through cross-validation. A z for DL, APEW, RPEW, and UA was 0.751, 0.795, 0.829, and 0.839, respectively. Multivariate analyses yielded the following significant CT quantitative features and associated A z when combined: RPEW and DL (A z = 0.861) when unenhanced images were not available and APEW and UA (A z = 0.889) when unenhanced images were available. Patient demographics and presence of a prior malignancy were additional significant factors, increasing A z to 0.903 and 0.927, respectively. The combined predictive classifier, without and with UA available, yielded 85.7% and 87.3% accuracies with cross-validation, respectively. When appropriately combined with other CT features, washout derived from intermediate-delay CT with or without additional clinical data has potential utility in differentiating malignant from benign adrenal lesions.

  15. Antihyperlipidemic activity of Ichnocarpus frutescens in triton WR-1339-induced and high-fat diet animals.

    PubMed

    Saravanan, M; Pandikumar, P; Prakash Babu, N; Ignacimuthu, S

    2011-10-01

    Ichnocarpus frutescens (L.) R.Br. (Apocynaceae) is used to treat diabetes and hyperlipidemia in folk medicine. The crude methanol extract and fractions of I. frutescens were investigated for antihyperlipidemic effect. Fresh leaves of I. frutescens were extracted with methanol and fractionated with hexane, benzene, ethyl acetate, acetone, and methanol. The active acetone fraction was subfractionated, which resulted in active fraction 3. The antihyperlipidemic effects of the methanol extract and fractions of I. frutescens were studied in triton WR-1339-induced and high-fat diet (HFD) obese animals. Further, lipid absorption and excretion were studied. The methanol extract significantly reduced total cholesterol (TC) by 29.63% and triglyceride (Tg) by 51.10% at 400 mg/kg in triton WR-1339-induced animals and significantly reduced TC (27.81%) and Tg (37.03%) at 400 mg/kg in HFD animals. Fraction 3 showed significant reduction in TC (25.03%) and Tg (58.05%) at 200 mg/kg. Feeding of HFD consisting 3% of fraction 3 increased feces weight and Tg level in mice. Fraction 3, showed significant decrease in plasma Tg level at the second hour, after oral administration of the lipid emulsion to rats. The observed properties apparently validate the folk medicinal use of this plant in amelioration of hyperlipidemia.

  16. Preschool Multiple-Breath Washout Testing. An Official American Thoracic Society Technical Statement.

    PubMed

    Robinson, Paul D; Latzin, Philipp; Ramsey, Kathryn A; Stanojevic, Sanja; Aurora, Paul; Davis, Stephanie D; Gappa, Monika; Hall, Graham L; Horsley, Alex; Jensen, Renee; Lum, Sooky; Milla, Carlos; Nielsen, Kim G; Pittman, Jessica E; Rosenfeld, Margaret; Singer, Florian; Subbarao, Padmaja; Gustafsson, Per M; Ratjen, Felix

    2018-03-01

    Obstructive airway disease is nonuniformly distributed throughout the bronchial tree, although the extent to which this occurs can vary among conditions. The multiple-breath washout (MBW) test offers important insights into pediatric lung disease, not available through spirometry or resistance measurements. The European Respiratory Society/American Thoracic Society inert gas washout consensus statement led to the emergence of validated commercial equipment for the age group 6 years and above; specific recommendations for preschool children were beyond the scope of the document. Subsequently, the focus has shifted to MBW applications within preschool subjects (aged 2-6 yr), where a "window of opportunity" exists for early diagnosis of obstructive lung disease and intervention. This preschool-specific technical standards document was developed by an international group of experts, with expertise in both custom-built and commercial MBW equipment. A comprehensive review of published evidence was performed. Recommendations were devised across areas that place specific age-related demands on MBW systems. Citing evidence where available in the literature, recommendations are made regarding procedures that should be used to achieve robust MBW results in the preschool age range. The present work also highlights the important unanswered questions that need to be addressed in future work. Consensus recommendations are outlined to direct interested groups of manufacturers, researchers, and clinicians in preschool device design, test performance, and data analysis for the MBW technique.

  17. Multiple breath washout analysis in infants: quality assessment and recommendations for improvement.

    PubMed

    Anagnostopoulou, Pinelopi; Egger, Barbara; Lurà, Marco; Usemann, Jakob; Schmidt, Anne; Gorlanova, Olga; Korten, Insa; Roos, Markus; Frey, Urs; Latzin, Philipp

    2016-03-01

    Infant multiple breath washout (MBW) testing serves as a primary outcome in clinical studies. However, it is still unknown whether current software algorithms allow between-centre comparisons. In this study of healthy infants, we quantified MBW measurement errors and tried to improve data quality by simply changing software settings. We analyzed best quality MBW measurements performed with an ultrasonic flowmeter in 24 infants from two centres in Switzerland with the current software settings. To challenge the robustness of these settings, we also used alternative analysis approaches. Using the current analysis software, the coefficient of variation (CV) for functional residual capacity (FRC) differed significantly between centres (mean  ±  SD (%): 9.8  ±  5.6 and 5.8  ±  2.9, respectively, p  =  0.039). In addition, FRC values calculated during the washout differed between  -25 and  +30% from those of the washin of the same tracing. Results were mainly influenced by analysis settings and temperature recordings. Changing few algorithms resulted in significantly more robust analysis. Non-systematic inter-centre differences can be reduced by using correctly recorded environmental data and simple changes in the software algorithms. We provide implications that greatly improve infant MBW outcomes' quality and can be applied when multicentre trials are conducted.

  18. Accurate Region-of-Interest Recovery Improves the Measurement of the Cell Migration Rate in the In Vitro Wound Healing Assay.

    PubMed

    Bedoya, Cesar; Cardona, Andrés; Galeano, July; Cortés-Mancera, Fabián; Sandoz, Patrick; Zarzycki, Artur

    2017-12-01

    The wound healing assay is widely used for the quantitative analysis of highly regulated cellular events. In this essay, a wound is voluntarily produced on a confluent cell monolayer, and then the rate of wound reduction (WR) is characterized by processing images of the same regions of interest (ROIs) recorded at different time intervals. In this method, sharp-image ROI recovery is indispensable to compensate for displacements of the cell cultures due either to the exploration of multiple sites of the same culture or to transfers from the microscope stage to a cell incubator. ROI recovery is usually done manually and, despite a low-magnification microscope objective is generally used (10x), repositioning imperfections constitute a major source of errors detrimental to the WR measurement accuracy. We address this ROI recovery issue by using pseudoperiodic patterns fixed onto the cell culture dishes, allowing the easy localization of ROIs and the accurate quantification of positioning errors. The method is applied to a tumor-derived cell line, and the WR rates are measured by means of two different image processing software. Sharp ROI recovery based on the proposed method is found to improve significantly the accuracy of the WR measurement and the positioning under the microscope.

  19. Wash-in and wash-out curves of sevoflurane and isoflurane in morbidly obese patients.

    PubMed

    Torri, G; Casati, A; Comotti, L; Bignami, E; Santorsola, R; Scarioni, M

    2002-06-01

    The aim of this prospective, randomized study is to compare sevoflurane and isoflurane pharmacokinetics in morbidly obese patients. With Ethical Committee approval and written informed consent, 14 obese patients (BMI >35 kg/m2), ASA physical status II, undergoing laparoscopic, silicone-adjustable gastric banding were randomly allocated to receive either sevoflurane (n=7) or isoflurane (n=7) as main anesthetic agents. General anesthesia was induced with 1 mg x kg-1 fentanyl, 6 mg x kg-1 sodium thiopental, and 1 mg x kg-1 succinylcholine followed by 0.4 mg kg-1 x h-1 atracurium bromide (doses were referred to ideal body weight). Intermittent positive pressure ventilation (IPPV) was applied using a Servo-900C ventilator with a nonrebreathing circuit and a 15 l x min-1 fresh gas flow (tidal volume: of 10 ml x kg-1; respiratory rate: 12 breaths/min; inspiratory to expiratory time ratio of 1:2) using an oxygen/air mixture (FiO2=50%), while supplemental boluses of thiopental or fentanyl were given as indicated in order to maintain blood pressure and heart rate values within +/-20% from baseline. After adequate placement of tracheal tube and stabilization of the ventilation parameters, 2% sevoflurane or 1.2% isoflurane was given for 30 min via a nonrebreathing circuit. End-tidal samples were collected at 1, 5, 10, 15, 20, 25 and 30 min, and measured using a calibrated infrared gas analyzer. General anesthesia was then maintained with the same inhalational agents, while supplemental fentanyl was given as indicated. After the last skin suture the inhalational agents were suspended, and the end tidal samples were collected at 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, and 5 min. Then the lungs were manually ventilated until extubation. No differences in age, gender and body mass index were reported between the two groups. Surgical procedure required 91+/-13 in the sevoflurane group and 83+/-32 min in the isoflurane group. The FA/FI ratio was higher in the sevoflurane group from the

  20. TC-99m MIBI SPECT imaging in patients with lung carcinoma: is it a functional probe of multidrug resistance genes?

    PubMed

    Ak, Ilknur; Gülbaş, Zafer; Ocak, Suna; Kaya, Eser; Alataş, Füsun; Vardareli, Erkan; Metintaş, Muzaffer

    2007-01-01

    Multidrug-resistance (MDR) phenotype concerns altered membrane transport that results in lower cell concentrations of cytotoxic drug in many cancer types, including lung cancer, and is related to the overexpression of a variety of proteins that act as adenosine triphosphate-dependent extrusion pumps. Tc-99m Sestamibi (MIBI) is a transport substrate for P-glycoprotein (Pgp) pump. In this study, we assessed the uptake and clearance of technetium-99m-2-hexakis 2-methoxyisobutylisonitrile (Tc-99m MIBI) from the tumor and its correlation with messenger RNA (mRNA) levels of Pgp, MDR-associated protein (MRP1), and lung resistance protein (LRP) in lung carcinoma. This study was carried out on 19 patients (mean age, 60.1 +/- 2.07 years) with advanced-stage lung carcinoma. The tumor samples obtained by bronchoscopy were assessed to estimate the levels of Pgp, MRP1, and LRP expression on mRNA level by quantitative real-time reverse-transcription polymerase chain reaction. Tc-99m MIBI chest imaging was performed 15 and 180 minutes after injection of 740 MBq Tc-99m MIBI. The early (T/Be) and delayed (T/Bd) Tc-99m MIBI uptakes and washout rate (WR) of Tc-99m MIBI from the tumor were measured. No correlation was found between the T/Be Tc-99m MIBI uptake of tumors (T/Be) and the levels of Pgp mRNA, MRP1 mRNA, and LRP mRNA by reverse-transcription polymerase chain reaction. There was a correlation between the mean T/Bd Tc-99m MIBI uptake and Pgp expression of the tumors (P = 0.001, Spearman rho = - 0.702). There was a correlation between the WR of Tc-99m MIBI from the tumor and Pgp expression of the tumor (P = 0.000, Spearman rho = 0.875). Washout rate of Tc-99m MIBI was not related to the levels of MRP1 mRNA (P = 0.93, Spearman rho = 0.02) or LRP mRNA (P = 0.47, Spearman rho = 0.177). Increased WR of Tc-99m MIBI is related in Pgp over expression of the tumor. Tc-99m MIBI single photon emission computed tomography imaging may be a functional probe of overexpression of Pgp in

  1. Special report on the data collection programs for the ground based nitrogen washout experiment. Volume 1: User's guide

    NASA Technical Reports Server (NTRS)

    Bueker, P. A.

    1982-01-01

    The Nitrogen Washout System measures nitrogen elimination on a breath basis from the body tissues of a subject breathing pure oxygen. The system serves as a prototype for a Space Shuttle Life Sciences experiment and in the Environmental Physiology Laboratory. Typically, a subject washes out body nitrogen for three hours while breathing oxygen from a mask enclosed in a positive-pressure oxygen tent. A nitrogen washout requires one test operator and the test subject. A DEC LSI-11/02 computer is used to (1) control and calibrate the mass spectrometer and Skylab spirometer, (2) gather and store experimental data and (3) provide limited real time analysis and more extensive post-experiment analysis. Five programs are used to gather and store the experimental data and perform all the real time control and analysis.

  2. Washout of ⁸²Rb as a marker of impaired tissue integrity, obtained by list-mode cardiac PET/CT: relationship with perfusion/metabolism patterns of myocardial viability.

    PubMed

    Chien, David T; Bravo, Paco; Higuchi, Takahiro; Merrill, Jennifer; Bengel, Frank M

    2011-08-01

    Myocardial washout of the potassium analogue (82)Rb may indicate tissue impairment. Few studies have evaluated its usefulness for viability assessment, and controversial results were reported. We revisited this topic using list-mode positron emission tomography (PET)/CT. A total of 22 patients with chronic ischemic cardiomyopathy (ICM) and 11 control subjects with normal CT coronary angiogram were studied. Rest (82)Rb PET/CT studies were acquired in list mode and resampled to static, gated, and dynamic images. Using a 17-segment model, (82)Rb washout was determined by monoexponential fitting of myocardial time-activity curves. In ICM patients, (18)F-fluorodeoxyglucose (FDG) studies were obtained in the same session and segments were classified as normally perfused, mismatch, or matched defect. (82)Rb washout was minimal and homogeneous in control subjects. Normally perfused segments of ICM did not differ (p = 0.33). ICM patients had a left ventricular ejection fraction (LVEF) of 25 ± 12%, 25/353 mismatched, and 46/353 matched defect segments. (82)Rb washout was higher in hypoperfused vs normal segments (p < 0.05), but not different between mismatch and matched defect (p = 0.18). Intraindividual analysis in nine patients showing both FDG mismatch and matched defect confirmed absence of differences. Overall, segmental (82)Rb washout correlated inversely with (82)Rb uptake (r = -0.70; p < 0.05) and less well with FDG uptake (r = -0.31; p < 0.05). Using state-of-the-art PET/CT technology for myocardial viability assessment, (82)Rb washout does not distinguish between perfusion/metabolism patterns of hibernating myocardium and scar. Tissue integrity may be at least partially impaired in hibernation.

  3. Relevance of I-BMIPP delayed scintigraphic imaging for patients with angina pectoris - a pilot study.

    PubMed

    Koyama, Kohei; Akashi, Yoshihiro J; Kida, Keisuke; Suzuki, Kengo; Ishibashi, Yuki; Musha, Haruki; Banach, Maciej

    2011-06-01

    The study was designed to clarify the role of (123)I-β-methyl-iodophenylpentadecanoic acid ((123)I-BMIPP) in the evaluation of myocardial fatty acid metabolism in patients with stable angina pectoris (AP) before and after percutaneous coronary intervention (PCI). TEN CONTROLS (MEAN AGE: 70.4 ±10.5 years) and 12 patients with AP (mean age: 67.4 ±11.6 years) and single vessel coronary artery disease participated in the radionuclide cardiac study. Scintigraphic images were acquired at 30 min and at 4 h after (123)I-BMIPP injection to determine early and delayed BMIPP uptake, respectively. The heart-to-mediastinum (H/M) ratio and the washout rate (WR) were calculated from the planar images. All patients underwent scintigraphy one day before PCI and again 1 month after successful PCI. NO SIGNIFICANT DIFFERENCES IN THE EARLY OR DELAYED H/M RATIOS WERE OBSERVED BETWEEN THE PATIENTS AND THE CONTROLS BEFORE PCI (EARLY: 2.70 ±0.36 vs. 2.73 ±0.57; delayed: 2.26 ±0.33 vs. 2.40 ±0.43; p > 0.2 for both). The early and delayed H/M ratios remained unchanged with the comparison with before PCI (early: 2.72 ±0.27, delayed: 2.23 ±0.22; p > 0.2 for both). The global WR before PCI was significantly higher in the patients than in the control group (36.7 ±9.3%, vs. 28.1 ±8.2%, p = 0.02). However, the WR after PCI did not significantly differ between the patients and the controls (34.3 ±7.8% vs. 28.1 ±8.2%, p = 0.1). These data may suggest that the WR of (123)I-BMIPP determined from the planar images enhances the presence of myocardial ischaemia.

  4. Relevance of 123I-BMIPP delayed scintigraphic imaging for patients with angina pectoris – a pilot study

    PubMed Central

    Koyama, Kohei; Akashi, Yoshihiro J.; Kida, Keisuke; Suzuki, Kengo; Ishibashi, Yuki; Musha, Haruki; Banach, Maciej

    2011-01-01

    Introduction The study was designed to clarify the role of 123I-β-methyl-iodophenylpentadecanoic acid (123I-BMIPP) in the evaluation of myocardial fatty acid metabolism in patients with stable angina pectoris (AP) before and after percutaneous coronary intervention (PCI). Material and methods Ten controls (mean age: 70.4 ±10.5 years) and 12 patients with AP (mean age: 67.4 ±11.6 years) and single vessel coronary artery disease participated in the radionuclide cardiac study. Scintigraphic images were acquired at 30 min and at 4 h after 123I-BMIPP injection to determine early and delayed BMIPP uptake, respectively. The heart-to-mediastinum (H/M) ratio and the washout rate (WR) were calculated from the planar images. All patients underwent scintigraphy one day before PCI and again 1 month after successful PCI. Results No significant differences in the early or delayed H/M ratios were observed between the patients and the controls before PCI (early: 2.70 ±0.36 vs. 2.73 ±0.57; delayed: 2.26 ±0.33 vs. 2.40 ±0.43; p > 0.2 for both). The early and delayed H/M ratios remained unchanged with the comparison with before PCI (early: 2.72 ±0.27, delayed: 2.23 ±0.22; p > 0.2 for both). The global WR before PCI was significantly higher in the patients than in the control group (36.7 ±9.3%, vs. 28.1 ±8.2%, p = 0.02). However, the WR after PCI did not significantly differ between the patients and the controls (34.3 ±7.8% vs. 28.1 ±8.2%, p = 0.1). Conclusions These data may suggest that the WR of 123I-BMIPP determined from the planar images enhances the presence of myocardial ischaemia. PMID:22295024

  5. Orbitally modulated dust formation by the WC7+O5 colliding-wind binary WR140

    NASA Astrophysics Data System (ADS)

    Williams, P. M.; Marchenko, S. V.; Marston, A. P.; Moffat, A. F. J.; Varricatt, W. P.; Dougherty, S. M.; Kidger, M. R.; Morbidelli, L.; Tapia, M.

    2009-05-01

    We present high-resolution infrared (2-18 μm) images of the archetypal periodic dust-making Wolf-Rayet binary system WR140 (HD 193793) taken between 2001 and 2005, and multi-colour (J - [19.5]) photometry observed between 1989 and 2001. The images resolve the dust cloud formed by WR140 in 2001, allowing us to track its expansion and cooling, while the photometry allows tracking the average temperature and total mass of the dust. The combination of the two data sets constrains the optical properties of the dust, and suggests that they differ from those of the dust made by the WC9 dust-makers, including the classical `pinwheel', WR104. The photometry of individual dust emission features shows them to be significantly redder in (nbL'-[3.99]), but bluer in ([7.9]-[12.5]), than the binary, as expected from the spectra of heated dust and the stellar wind of a Wolf-Rayet star. The most persistent dust features, two concentrations at the ends of a `bar' of emission to the south of the star, were observed to move with constant proper motions of 324 +/- 8 and 243 +/- 7 mas yr-1. Longer wavelength (4.68 and 12.5 μm) images show dust emission from the corresponding features from the previous (1993) periastron passage and dust formation episode, showing that the dust expanded freely in a low-density void for over a decade, with dust features repeating from one cycle to the next. A third persistent dust concentration to the east of the binary (the `arm') was found to have a proper motion ~320 mas yr-1, and a dust mass about one-quarter that of the `bar'. Extrapolation of the motions of the concentrations back to the binary suggests that the eastern `arm' began expansion four to five months earlier than those in the southern `bar', consistent with the projected rotation of the binary axis and wind-collision region (WCR) on the sky. A comparison of model dust images and the observations constrains the intervals when the WCR was producing sufficiently compressed wind for dust

  6. Computationally-efficient optical coherence elastography to assess degenerative osteoarthritis based on ultrasound-induced fringe washout (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Tong, Minh Q.; Hasan, M. Monirul; Gregory, Patrick D.; Shah, Jasmine; Park, B. Hyle; Hirota, Koji; Liu, Junze; Choi, Andy; Low, Karen; Nam, Jin

    2017-02-01

    We demonstrate a computationally-efficient optical coherence elastography (OCE) method based on fringe washout. By introducing ultrasound in alternating depth profile, we can obtain information on the mechanical properties of a sample within acquisition of a single image. This can be achieved by simply comparing the intensity in adjacent depth profiles in order to quantify the degree of fringe washout. Phantom agar samples with various densities were measured and quantified by our OCE technique, the correlation to Young's modulus measurement by atomic force micrscopy (AFM) were observed. Knee cartilage samples of monoiodo acetate-induced arthiritis (MIA) rat models were utilized to replicate cartilage damages where our proposed OCE technique along with intensity and birefringence analyses and AFM measurements were applied. The results indicate that our OCE technique shows a correlation to the techniques as polarization-sensitive OCT, AFM Young's modulus measurements and histology were promising. Our OCE is applicable to any of existing OCT systems and demonstrated to be computationally-efficient.

  7. Importance of compensatory heart rate increase during myocardial ischemia to preserve appropriate oxygen kinetics.

    PubMed

    Yoshida, Sadamitsu; Adachi, Hitoshi; Murata, Makoto; Tomono, Junichi; Oshima, Shigeru; Kurabayashi, Masahiko

    2017-09-01

    Myocardial ischemia induces cardiac dysfunction, resulting in insufficient oxygen supply to peripheral tissues and mismatched energy production during exercise. To relieve the insufficient oxygen supply, heart rate (HR) response is augmented; however, beta-adrenergic receptor blockers (BB) restrict HR response. Although BB are essential drugs for angina pectoris, the effect of BB on exercise tolerance in patients with angina has not been studied. The aim of this study was to clarify the importance of HR augmentation to preserve exercise tolerance in patients with angina pectoris. Forty-two subjects who underwent cardiopulmonary exercise testing (CPX) to detect myocardial ischemia were enrolled. CPX was performed until exhaustion or onset of significant myocardial ischemia using a ramp protocol. Subjects were assigned to three groups (Group A: with ST depression during CPX with significant coronary stenosis and taking BB; Group B: with ST depression and not taking BB; Group C: without ST depression and not taking BB). HR response to exercise was evaluated during the following two periods: below and above ischemic threshold (IT). In Group C, it was evaluated during the first 2min and the last 2min of a ramp exercise. No significant differences were observed among the three groups with regard to patients' basic characteristics. Below IT, there were no differences in oxygen pulse/watt (O 2 pulse increasing rate), HR/watt (ΔHR/ΔWR), and ΔV˙O 2 /ΔWR. Above IT, O 2 pulse increasing rate was greater in Group A than in Group B. ΔHR/ΔWR was smaller in Group A than in Group B. ΔV˙O 2 /ΔWR became smaller in Group A than in Group B. There was no difference in anaerobic threshold, and peak V˙O 2 was smaller in Group A than in Group B. Restriction of HR response by a BB is shown to be one of the important factors in diminished exercise tolerance. Copyright © 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

  8. Strong washout approximation to resonant leptogenesis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Garbrecht, Björn; Gautier, Florian; Klaric, Juraj, E-mail: garbrecht@tum.de, E-mail: florian.gautier@tum.de, E-mail: juraj.klaric@tum.de

    We show that the effective decay asymmetry for resonant Leptogenesis in the strong washout regime with two sterile neutrinos and a single active flavour can in wide regions of parameter space be approximated by its late-time limit ε=Xsin(2φ)/(X{sup 2}+sin{sup 2}φ), where X=8πΔ/(|Y{sub 1}|{sup 2}+|Y{sub 2}|{sup 2}), Δ=4(M{sub 1}-M{sub 2})/(M{sub 1}+M{sub 2}), φ=arg(Y{sub 2}/Y{sub 1}), and M{sub 1,2}, Y{sub 1,2} are the masses and Yukawa couplings of the sterile neutrinos. This approximation in particular extends to parametric regions where |Y{sub 1,2}|{sup 2}>> Δ, i.e. where the width dominates the mass splitting. We generalise the formula for the effective decay asymmetry to themore » case of several flavours of active leptons and demonstrate how this quantity can be used to calculate the lepton asymmetry for phenomenological scenarios that are in agreement with the observed neutrino oscillations. We establish analytic criteria for the validity of the late-time approximation for the decay asymmetry and compare these with numerical results that are obtained by solving for the mixing and the oscillations of the sterile neutrinos. For phenomenologically viable models with two sterile neutrinos, we find that the flavoured effective late-time decay asymmetry can be applied throughout parameter space.« less

  9. Training in multiple breath washout testing for respiratory physiotherapists.

    PubMed

    O'Neill, Katherine; Elborn, J Stuart; Tunney, Michael M; O'Neill, Philip; Rowan, Stephen; Martin, Susan; Bradley, Judy M

    2018-03-01

    The development of multiple breath washout (MBW) testing in respiratory disease highlights the need for increased awareness amongst respiratory physiotherapists and a potential opportunity for professional development in the use of an important outcome measure for clinical trials. To rationalise how MBW may be a useful assessment tool for respiratory physiotherapists and to describe a local MBW training and certification programme for physiotherapists. The respiratory Multidisciplinary Team in the Belfast Health and Social Care Trust (BHSCT) identified a need for MBW testing to be available to facilitate clinical research and assessment. A 2day training programme consisting of prereading preparation, self-directed learning, theory presentations, practical demonstrations and hands-on practice was developed and delivered. All participants underwent a certification process. We have demonstrated the successful training and certification of clinical and research physiotherapists and encourage other respiratory physiotherapists to consider MBW test training. Copyright © 2017 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.

  10. The in vitro antibiotic release from anti-washout apatite cement using chitosan.

    PubMed

    Takechi, Masaaki; Miyamoto, Youji; Momota, Yukihiro; Yuasa, Tetsuya; Tatehara, Seikou; Nagayama, Masaru; Ishikawa, Kunio; Suzuki, Kazuomi

    2002-10-01

    The in vitro antibiotic release from anti-washout apatite cement using chitosan (aw-AC(chi)) was investigated in a preliminary evaluation. Flomoxef sodium was employed as the antibiotic and was incorporated into the powder phase aw-AC(chi) at up to 10%. The setting times were measured for aw-AC(chi) containing various amounts of flomoxef sodium. X-ray diffraction (XRD) analysis was also conducted for the identification of products. To evaluate the drug release profile, set aw-AC was immersed in saline and the released flomoxef sodium was determined at regular intervals. The setting time was prolonged slightly with the addition of flomoxef sodium. The difference at 10% flomoxef sodium (0% vs. 10%) was not significant (p>0.05), and can be negligible in clinic. The XRD analysis revealed that formation of hydroxyapatite (HAP) from aw-AC(chi) was reduced, even after 24 h, when the aw-AC(chi) contained flomoxef sodium at 8% or more. The flomoxef sodium release from aw-AC(chi) showed the typical profile observed in skeleton type drug delivery system (DDS). Changing the concentration of chitosan can control the rate of drug release from aw-AC. Therefore, we conclude that aw-AC(chi) is a good candidate for potential use as a DDS carrier that may be useful in surgical operations.

  11. Gravitational independence of single-breath washout tests in recumbent dogs

    NASA Technical Reports Server (NTRS)

    Tomioka, Shinichi; Kubo, Susumu; Guy, Harold J. B.; Prisk, G. K.

    1988-01-01

    The effect of gravitational orientation in the mechanism of lung filling and emptying in dogs was examined by conducting simultaneously Ar-bolus and N2 single-breath washout tests (SBWTs) in 10 anesthetized dogs (prone and supine), with three of the dogs subjected to body rotation. Transpulmonary pressure was measured simultaneously, allowing identification of the lung volume above residual volume at which there was an inflection point in the pressure-volume curve. Combined resident gas and bolus SBWTs in recumbent dogs were found to be different from such tests in humans; in dogs, the regional distribution of ventilation was not primarily determined by gravity. The measurements did not make it possible to discern exact mechanisms of filling and emptying, but both processes appear to be related to lung, thorax, and mediastinum interactions and/or differences in regional mechanical properties of the lungs.

  12. Determination of washout performance of various monochrome displays under simulated flight ambient and solar lighting conditions

    NASA Technical Reports Server (NTRS)

    Batson, Vernon M.; Robertson, James B.; Parrish, Russell V.

    1990-01-01

    The aircraft cockpit ambient lighting simulation system (ACALSS) has been developed to study display readability and associated pilot/vehicle performance effects in a part-task simulator cockpit. In the study reported here, the ACALSS was used to determine the illumination levels at which subjects lose the ability to maintain aircraft states when using three display technologies as display media for primary flight displays: a standard monochrome EL (electroluminescent) flat-panel, a laboratory-class monochrome CRT, and an enhanced-brightness EL flat-panel. The multivariate statistical technique of modified profile analysis was used to test for performance differences between display devices as functions of illumination levels. The standard monochrome EL flat-panel display began to washout after the 2500 foot-candle level of illumination. The monochrome CRT began to washout after the 5500 foot-candle level of illumination. No performance decrements by increased illumination up to the 12,000 foot-candle level were found for the enhanced-brightness EL flat-panel display. What was not anticipated was that half the subjects would subjectively prefer the CRT over the enhanced-brightness EL, even though their performance errors would have indicated the opposite.

  13. Helium Star Models with Optically Thick Winds: Implications for the Internal Structures and Mass-loss Rates of Wolf–Rayet Stars

    NASA Astrophysics Data System (ADS)

    Nakauchi, Daisuke; Saio, Hideyuki

    2018-01-01

    We construct helium (He) star models with optically thick winds and compare them with the properties of Galactic Wolf–Rayet (WR) stars. Hydrostatic He-core solutions are connected smoothly to trans-sonic wind solutions that satisfy the regularity conditions at the sonic point. Velocity structures in the supersonic parts are assumed by a simple β-type law. By constructing a center-to-surface structure, a mass-loss rate {\\dot{M}}{{w}} can be obtained as an eigenvalue of the equations. Sonic points appear at temperatures ≈ (1.8{--}2.8)× {10}5 {{K}} below the Fe-group opacity peak, where the radiation force becomes comparable to the local gravity. Photospheres are located at radii 3–10 times larger than sonic points. The obtained mass-loss rates are comparable to those of WR stars. Our {\\dot{M}}{{w}}–luminosity relation agrees well with the relation recently obtained by Gräfener et al. Photospheric temperatures of WR stars tend to be cooler than our predictions. We discuss the effects of stellar evolution, detailed radiation transfer, and wind clumping, which are ignored in this paper.

  14. Erratum: The 2.27 day period of WR-134 (HD 191765)

    NASA Astrophysics Data System (ADS)

    McCandliss, Stephan R.; Bohannan, Bruce; Robert, Carmelle; Moffat, Anthony F. J.

    1994-11-01

    The original temporal analysis of a 12 night spectral timeseries of Wolf-Rayet (WR)-134 has been found to be flawed and a re-analysis shows that the line profile variations are indeed periodic. When combined with a 4 night timeseries taken 45 days earlier, a period near 2.27 d is found in periodograms of the He II lambda 5412 line centroid, rms line width, and line skew variations. When the emission line residuals are ordered as a function of phase, a sinuous feature appears to 'snake' about the line center with an amplitude of +/-500 km/s. This is approximately equal to 20 larger than the line centroid amplitude; the calculation of which is heavily weighted by static portions of the line profile. In addition to the 'snake,' emission residuals appear that move away from line center on unbound trajectories and are thought to result from the interaction of a periodic driver with the unstable flow of the radiation driven wind.

  15. Erratum: The 2.27 day period of WR-134 (HD 191765)

    NASA Technical Reports Server (NTRS)

    Mccandliss, Stephan R.; Bohannan, Bruce; Robert, Carmelle; Moffat, Anthony F. J.

    1994-01-01

    The original temporal analysis of a 12 night spectral timeseries of Wolf-Rayet (WR)-134 has been found to be flawed and a re-analysis shows that the line profile variations are indeed periodic. When combined with a 4 night timeseries taken 45 days earlier, a period near 2.27 d is found in periodograms of the He II lambda 5412 line centroid, rms line width, and line skew variations. When the emission line residuals are ordered as a function of phase, a sinuous feature appears to 'snake' about the line center with an amplitude of +/-500 km/s. This is approximately equal to 20 larger than the line centroid amplitude; the calculation of which is heavily weighted by static portions of the line profile. In addition to the 'snake,' emission residuals appear that move away from line center on unbound trajectories and are thought to result from the interaction of a periodic driver with the unstable flow of the radiation driven wind.

  16. Radioprotective effects of Sipunculus nudus L. polysaccharide combined with WR-2721, rhIL-11 and rhG-CSF on radiation-injured mice

    PubMed Central

    Jiang, Shuqi; Shen, Xianrong; Liu, Yuming; He, Ying; Jiang, Dingwen; Chen, Wei

    2015-01-01

    This study investigated the radioprotective effect of Sipunculus nudus L. polysaccharide (SNP) in combination with WR-2721, rhIL-11 and rhG-CSF on irradiated mice. A total of 70 Imprinting Control Region (ICR) mice were divided into seven groups: the control group, the model group and five administration groups. All groups, except the control group, were exposed to a 5 Gy 60Co γ-ray beam. Blood parameters [including white blood cell (WBC), red blood cell (RBC) and platelet counts and hemoglobin level] were assessed three days before irradiation, and the on the 3rd, 7th and 14th days after irradiation. Spleen, thymus and testicular indices, DNA contents of bone marrow cells, bone marrow nucleated cells, sperm counts, superoxide dismutase (SOD), malondialdehyde (MDA), testosterone and estradiol levels in the serum were assessed on the 14th day after irradiation. The combined administration of SNP, WR-2721, rhIL-11 and rhG-CSF exerted synergistic recovery effects on peripheral blood WBC, RBC and platelet counts and hemoglobin levels in irradiated mice, and synergistic promotion effects on spleen, thymus, testicle, bone marrow nucleated cells and sperm counts in irradiated mice. The synergistic administration increased the serum SOD activities and serum testosterone content of irradiated mice, but synergy decreased the content of serum MDA and estradiol in irradiated mice. These results suggest that the combined administration of SNP, WR-2721, rhIL-11 and rhG-CSF should increase the efficacy of these drugs for acute radiation sickness, protect immunity, hematopoiesis and the reproductive organs of irradiated-damaged mice, and improve oxidation resistance in the body. PMID:25852150

  17. The risk of river pollution due to washout from contaminated floodplain water bodies during high floods

    NASA Astrophysics Data System (ADS)

    Lyubimova, Tatyana; Lepikhin, Anatoly; Parshakova, Yanina; Tiunov, Alexey

    2016-04-01

    Today, the potential impact of extremely high floods, which in the last years have become a rather frequent weather-related disaster, is the problem of primary concern. In studies of the potential impact of floods the emphasis is placed first of all on the estimation of possible flood zones and the analysis of the flow regimes in these zones. However, in some cases the hydrochemical parameters related to changes in the chemical composition of water are more important than the hydraulic parameters. It is generally believed that the higher is the flow rate, the more intensive is the process of dissolution, i.e. the lower is the concentration of limiting contaminants in water. However, this statement is valid provided that flooding does not activate new sources of water pollution such as contaminated floodplain water bodies located in the vicinity of water supply systems. Being quite reliable and safe at small and moderate discharges, in the case of extremely high level of river waters they become intensive sources of water pollution, essentially limiting the water consumption schedule for downstream water consumers. It should be noted that compared to the well-studied mechanisms of waste discharge due to failure of hydraulic engineering structures by flood waves, the mechanisms of pollutant washout from the contaminated floodplain water bodies by the flood waves is still poorly understood. We analyze the impacts of such weather-related events on the quality of water in the water intake system, taking as an example, the section of the Vyatka River located in the Prikamskaya lowland of the Russian Federation. The risk of river pollution due to washout from the contaminated floodplain water bodies during high floods is studied by hydrodynamical modeling in the framework of combined approach using one-, two- and three-dimensional hydrodynamic models are implemented and by in situ measurements. It is shown that during high floods the removal of pollutants from the

  18. Percutaneous debridement and washout of walled-off abdominal abscess and necrosis using flexible endoscopy: a large single-center experience.

    PubMed

    Mathers, Bradley; Moyer, Matthew; Mathew, Abraham; Dye, Charles; Levenick, John; Gusani, Niraj; Dougherty-Hamod, Brandy; McGarrity, Thomas

    2016-01-01

    Direct percutaneous endoscopic necrosectomy has been described as a minimally invasive intervention for the debridement of walled-off pancreatic necrosis (WOPN). In this retrospective cohort study, we aimed to confirm these findings in a US referral center and evaluate the clinical value of this modality in the treatment of pancreatic necrosis as well as other types of intra-abdominal fluid collections and necrosis. Twelve consecutive patients with WOPN or other abdominal abscess requiring debridement and washout underwent computed tomography (CT)-guided drainage catheter placement. Each patient then underwent direct percutaneous endoscopic necrosectomy and washout with repeat debridement performed until complete. Drains were then removed once output fell below 30 mL/day and imaging confirmed resolution. The primary endpoints were time to clinical resolution and sustained resolution at 1-year follow up.  Ten patients were treated for WOPN, one for necrotic hepatic abscesses, and one for omental necrosis. The median time to intervention was 85 days with an average of 2.3 necrosectomies performed. Complete removal of drains was accomplished in 11 patients (92 %). The median time to resolution was 57 days. No serious adverse events occurred; however, one patient developed pancreaticocutaneous fistulas. Ten patients completed 1-year surveillance of which none required drain replacement. No patients required surgery or repeat endoscopy. This series supports the premise that direct percutaneous endoscopic necrosectomy is a safe and effective intervention for intra-abdominal fluid collections and necrosis in appropriately selected patients. Our study demonstrates a high clinical success rate with minimal adverse events. This modality offers several potential advantages over surgical and transgastric approaches including use of improved accessibility, an excellent safety profile, and requirement for only deep or moderate sedation.

  19. The effect of rain characteristics on scavenging rate of tritium-oxide from the atmosphere

    NASA Astrophysics Data System (ADS)

    Piskunov, V. N.; Golubev, A. V.; Balashov, Yu. S.; Mavrin, S. V.; Golubeva, V. N.; Aleinikov, A. Yu.; Kovalenko, V. P.; Solomatin, I. I.

    2012-12-01

    The results of field experiments, involving HTO scavenging from the atmosphere by precipitation in the vicinity of HT and HTO emission sources, are presented. The experiments were aimed at obtaining direct experimental data on atmospheric HTO scavenging for a variety of rain characteristics (rain intensity and drop spectra).The most reliable are the calculations of the rate of wash-out with precipitation with the use of the method of integration of the constant exchange for a spectrum of drops. The results of such calculations are in good agreement with the experimental data and can serve as a basis for the generalized parameterization dependences. It is shown that the exact calculation can be replaced by a simpler formula using the mean-value theorem.For the known approximations of the spectra of the rain drops, formulas were obtained to give parameterization dependence of the rate of wash-out Λ on the intensity of precipitation p. This approach can be used for rapid assessment, as well as to determine parameters of wash-out of gases with precipitation in the numerical complexes, which are used for the calculation of the transfer and removal of impurities from the atmosphere.

  20. Utilizing a Suited Manikin Test Apparatus and Spacesuit Ventilation Loop to Evaluate Carbon Dioxide Washout

    NASA Technical Reports Server (NTRS)

    Chullen, Cinda; Conger, Bruce; Korona, Adam; Kanne, Bryan; McMillin, Summer; Norcross, Jason; Jeng, Frank; Swickrath, Mike

    2014-01-01

    NASA is pursuing technology development of an Advanced Extravehicular Mobility Unit (AEMU) which is an integrated assembly made up of primarily a pressure garment system and a Portable Life Support System (PLSS). The PLSS is further composed of an oxygen subsystem, a ventilation subsystem, and a thermal subsystem. One of the key functions of the ventilation system is to remove and control the carbon dioxide delivered to the crewmember. Carbon dioxide washout is the mechanism by which CO2 levels are controlled within the spacesuit helmet to limit the concentration of CO2 inhaled by the crew member. CO2 washout performance is a critical parameter needed to ensure proper and robust designs that are insensitive to human variabilities in a spacesuit. A Suited Manikin Test Apparatus (SMTA) is being developed to augment testing of the PLSS ventilation loop in order to provide a lower cost and more controlled alternative to human testing. The CO2 removal function is performed by the regenerative Rapid Cycle Amine (RCA) within the PLSS ventilation loop and its performance is evaluated within the integrated SMTA and Ventilation Loop test system. This paper will provide a detailed description of the schematics, test configurations, and hardware components of this integrated system. Results and analysis of testing performed with this integrated system will be presented within this paper.

  1. Ventilation Inception and Washout, Scaling, and Effects on Hydrodynamic Performance of a Surface Piercing Strut

    NASA Astrophysics Data System (ADS)

    Harwood, Casey; Young, Yin Lu; Ceccio, Steven

    2014-11-01

    High-lift devices that operate at or near a fluid free surface (such as surface-piercing or shallowly-submerged propellers and hydrofoils) are prone to a multiphase flow phenomenon called ventilation, wherein non-condensable gas is entrained in the low-pressure flow, forming a cavity around the body and dramatically altering the global hydrodynamic forces. Experiments are being conducted at the University of Michigan's towing tank using a canonical surface-piercing strut to investigate atmospheric ventilation. The goals of the work are (i) to gain an understanding of the dominant physics in fully wetted, partially ventilated, and fully ventilated flow regimes, (ii) to quantify the effects of governing dimensionless parameters on the transition between flow regimes, and (iii) to develop scaling relations for the transition between flow regimes. Using theoretical arguments and flow visualization techniques, new criteria are developed for classifying flow regimes and transition mechanisms. Unsteady transition mechanisms are described and mapped as functions of the governing non-dimensional parameters. A theoretical scaling relationship is developed for ventilation washout, which is shown to adequately capture the experimentally-observed washout boundary. This material is based upon work supported by the National Science Foundation Graduate Student Research Fellowship under Grant No. DGE 1256260. Support also comes from the Naval Engineering Education Center (Award No. N65540-10-C-003).

  2. A Novel Physiological Investigation of the Functional Residual Capacity by the Bias Flow Nitrogen Washout Technique in Infants

    PubMed Central

    Morris, Mohy G.

    2011-01-01

    Summary The dynamic functional residual capacity (FRCdyn), the lung volume most routinely measured in infants, is an unreliable volume landmark. In addition to the FRCdyn, we measured the (passive) static FRC (FRCst) by inducing a brief post-hyperventilation apnea (PHA) in 33 healthy infants aged 7.4–127.2 weeks. A commercial system for nitrogen (N2) washout to measure FRC, and a custom made system to monitor and record flow and airwayopening pressure signals in real-time were used in unison. Infants were manually hyperventilated to induce a PHA. After the last passive expiration, FRCst was estimated by measuring the volume of N2 expired after end-passive expiratory switching of the inspired gas from room air to 100% oxygen during the post-expiratory apneic pause. Repeatable intrasubject FRCst and FRCdyn measurements overlapped in most infants including the younger ones (P = 0.2839). Mean (95% confidence interval [CI]) FRCst was 21.1 (20.0–22.3), and error-corrected FRCdyn was 21.4 (20.4–22.4) ml/kg. Mean (washout time [t]) tFRCst was longer than tFRCdyn 60 sec (95% CI 55–65) versus 47 sec (95% CI 43–51) (P<0.0001). The FRC and washout time were dependent on body length, weight and age. We conclude that the FRCst is not different from the FRCdyn in infants. The FRCst is a reliable volume landmark because the PHA stabilizes the end-expiratory level by potentially abolishing the sedated infant’s breathing strategies. The FRCst lacks potential sources of errors and disadvantages associated with measuring the FRCdyn. The findings cast significant doubt on the traditional physiology of air trapping in healthy infants’ lungs. PMID:19499588

  3. Continuous distributions of specific ventilation recovered from inert gas washout

    NASA Technical Reports Server (NTRS)

    Lewis, S. M.; Evans, J. W.; Jalowayski, A. A.

    1978-01-01

    A new technique is described for recovering continuous distributions of ventilation as a function of tidal ventilation/volume ratio from the nitrogen washout. The analysis yields a continuous distribution of ventilation as a function of tidal ventilation/volume ratio represented as fractional ventilations of 50 compartments plus dead space. The procedure was verified by recovering known distributions from data to which noise had been added. Using an apparatus to control the subject's tidal volume and FRC, mixed expired N2 data gave the following results: (a) the distributions of young, normal subjects were narrow and unimodal; (b) those of subjects over age 40 were broader with more poorly ventilated units; (c) patients with pulmonary disease of all descriptions showed enlarged dead space; (d) patients with cystic fibrosis showed multimodal distributions with the bulk of the ventilation going to overventilated units; and (e) patients with obstructive lung disease fell into several classes, three of which are illustrated.

  4. Is 123I-metaiodobenzylguanidine heart-to-mediastinum ratio dependent on age? From Japanese Society of Nuclear Medicine normal database.

    PubMed

    Nakajima, Kenichi; Okuda, Koichi; Matsuo, Shinro; Wakabayashi, Hiroshi; Kinuya, Seigo

    2018-04-01

    Heart-to-mediastinum ratios (HMRs) of 123 I-metaiodobenzylguanidine (MIBG) have usually been applied to prognostic evaluations of heart failure and Lewy body disease. However, whether these ratios depend on patient age has not yet been clarified using normal databases. We analyzed 62 patients (average age 57 ± 19 years, male 45%) derived from a normal database of the Japanese Society of Nuclear Medicine working group. The HMR was calculated from early (15 min) and delayed (3-4 h) anterior planar 123 I-MIBG images. All HMRs were standardized to medium-energy general purpose (MEGP) collimator equivalent conditions using conversion coefficients for the collimator types. Washout rates (WR) were also calculated, and we analyzed whether early and late HMR, and WR are associated with age. Before standardization of HMR to MEGP collimator conditions, HMR and age did not significantly correlate. However, late HMR significantly correlated with age after standardization: late HMR = - 0.0071 × age + 3.69 (r 2  = 0.078, p = 0.028), indicating that a 14-year increase in age corresponded to a decrease in HMR of 0.1. Whereas the lower limit (2.5% quantile) of late HMR was 2.3 for all patients, it was 2.5 and 2.0 for those aged ≤ 63 and > 63 years, respectively. Early HMR tended to be lower in subjects with the higher age (p = 0.076), whereas WR was not affected by age. While late HMR was slightly decreased in elderly patients, the lower limit of 2.2-2.3 can still be used to determine both early and late HMR.

  5. Multiple-Breath Washout Outcomes Are Sensitive to Inflammation and Infection in Children with Cystic Fibrosis.

    PubMed

    Ramsey, Kathryn A; Foong, Rachel E; Grdosic, Jasmine; Harper, Alana; Skoric, Billy; Clem, Charles; Davis, Miriam; Turkovic, Lidija; Stick, Stephen M; Davis, Stephanie D; Ranganathan, Sarath C; Hall, Graham L

    2017-09-01

    The lung clearance index is a measure of ventilation distribution derived from the multiple-breath washout technique. The lung clearance index is increased in the presence of lower respiratory tract inflammation and infection in infants with cystic fibrosis; however, the associations during the preschool years are unknown. We assessed the ability of the lung clearance index to detect the presence and extent of lower respiratory tract inflammation and infection in preschool children with cystic fibrosis. Ventilation distribution outcomes were assessed at 82 visits with 58 children with cystic fibrosis and at 38 visits with 31 healthy children aged 3-6 years. Children with cystic fibrosis also underwent bronchoalveolar lavage fluid collection for detection of lower respiratory tract inflammation and infection. Associations between multiple-breath washout indices and the presence and extent of airway inflammation and infection were assessed using linear mixed effects models. Lung clearance index was elevated in children with cystic fibrosis (mean [SD], 8.00 [1.45]) compared with healthy control subjects (6.67 [0.56]). In cystic fibrosis, the lung clearance index was elevated in individuals with lower respiratory tract infections (difference compared with uninfected [95% confidence interval], 0.62 [0.06, 1.18]) and correlated with the extent of airway inflammation. These data suggest that the lung clearance index may be a useful surveillance tool for monitoring the presence and extent of lower airway inflammation and infection in preschool children with cystic fibrosis.

  6. Comparison of heliox and oxygen as washing gases for the nitrogen washout technique in preterm infants.

    PubMed

    Poets, C F; Rau, G A; Gappa, M; Seidenberg, J

    1996-06-01

    The nitrogen washout technique usually involves exposure of the patient to 100% oxygen for several minutes. This may be dangerous in preterm infants who are at risk of retinopathy of prematurity (ROP). We wanted to know whether heliox (79% He, 21% O2) can be used instead of oxygen when determining functional residual capacity (FRC). FRC measurements were made in 14 preterm infants [median (range) gestational age at birth 34 wk (27-37 wk), and at time of study 36 wk (33-40 wk)] who were breathing room air. FRC was measured using a computerized infant pulmonary function system, beginning in random order with either 100% O2 followed by heliox or vice versa. There was no systematic difference between the two methods with regard to lung volume measurements: mean (SD) FRC values, corrected for body weight, were 22.9 (7.1) mL/kg for O2 and 23.4 (7.0) mL/kg for heliox. We did not observe a systematic influence of the type of washing gas used (heliox or oxygen) on FRC in these infants. Our results suggest that the use of heliox instead of pure oxygen may be a suitable and safer alternative for FRC measurements with the nitrogen washout technique in preterm infants who are breathing low concentrations of inspired oxygen and are still at risk of ROP.

  7. Utilizing a Suited Manikin Test Apparatus and Space Suit Ventilation Loop to Evaluate Carbon Dioxide Washout

    NASA Technical Reports Server (NTRS)

    Chullen, Cinda; Conger, Bruce; Korona, Adam; Kanne, Bryan; McMillin, Summer; Paul, Thomas; Norcross, Jason; Alonso, Jesus Delgado; Swickrath, Mike

    2015-01-01

    NASA is pursuing technology development of an Advanced Extravehicular Mobility Unit (AEMU) which is an integrated assembly made up of primarily a pressure garment system and a portable life support subsystem (PLSS). The PLSS is further composed of an oxygen subsystem, a ventilation subsystem, and a thermal subsystem. One of the key functions of the ventilation system is to remove and control the carbon dioxide (CO2) delivered to the crewmember. Carbon dioxide washout is the mechanism by which CO2 levels are controlled within the space suit helmet to limit the concentration of CO2 inhaled by the crew member. CO2 washout performance is a critical parameter needed to ensure proper and robust designs that are insensitive to human variabilities in a space suit. A suited manikin test apparatus (SMTA) was developed to augment testing of the PLSS ventilation loop in order to provide a lower cost and more controlled alternative to human testing. The CO2 removal function is performed by the regenerative Rapid Cycle Amine (RCA) within the PLSS ventilation loop and its performance is evaluated within the integrated SMTA and Ventilation Loop test system. This paper will provide a detailed description of the schematics, test configurations, and hardware components of this integrated system. Results and analysis of testing performed with this integrated system will be presented within this paper.

  8. VizieR Online Data Catalog: NIR spectroscopy of Galactic WR stars. III (Kanarek+, 2015)

    NASA Astrophysics Data System (ADS)

    Kanarek, G.; Shara, M.; Faherty, J.; Zurek, D.; Moffat, A.

    2016-02-01

    This survey was previously described in Paper I (Shara et al., 2009AJ....138..402S). More than 88000 exposures were taken of the Galactic plane on the Cerro Tololo Inter-American Observatory (CTIO) 1.5-m telescope over approximately 200 nights during 2005-2006. IRTF: at the 3m NASA Infrared Telescope Facility (IRTF), we obtained NIR spectra of 150 candidate WR stars, selected using the criteria above, with the SpeX spectrograph. MDM 2011: during a run of excellent weather over the seven nights in 2011 June, we obtained 113 NIR spectra of candidate stars using TIFKAM in spectroscopic mode on the 2.4m Hiltner telescope at MDM Observatory. MDM 2012: during early 2012, the original survey data were reduced again, using different methods to produce better images. (10 data files).

  9. The first orbital solution for the massive colliding-wind binary HD 93162 (≡ WR 25)

    NASA Astrophysics Data System (ADS)

    Gamen, R.; Gosset, E.; Morrell, N. I.; Niemela, V. S.; Sana, H.; Nazé, Y.; Rauw, G.; Barbá, R. H.; Solivella, G. R.

    2008-08-01

    Since the discovery, with EINSTEIN, of strong X-ray emission associated with HD 93162, this object was recurrently predicted by some authors to be a colliding-wind binary system. However, radial-velocity variations that would prove the suspected binary nature have never been found so far. We spectroscopically monitored this object in order to investigate its possible variability and to provide an answer to the above-mentioned discordance. We derived radial velocities from spectroscopic data acquired mainly between 1994 and 2006, and searched for periodicities. For the first time, periodic radial-velocity variations are detected. Our analysis definitively shows that the Wolf-Rayet star WR 25 is actually an eccentric binary system with a probable period of about 208 days.

  10. How do Swedish day center attendees with psychiatric disabilities view their worker role? A structural equation modeling study.

    PubMed

    Eklund, Mona; Bäckström, Martin; Bejerholm, Ulrika

    2018-05-01

    To investigate how day center attendees with psychiatric disabilities perceived their worker role and the importance of current work situation and personal factors in that respect. Two-hundred attendees completed the Worker Role Self-assessment and questionnaires addressing possible predictors of the worker role: current employment situation, satisfaction with that situation, and a personal factor (encompassing self-esteem, self-mastery and engagement). Structural equation modeling was used. A model indicated two worker role factors; belief in a future worker role (WR1) and current capacities and routines (WR2). WR1 was positively influenced by having a job, younger age and the personal factor. Satisfaction with current work situation (usually unemployment) was negatively associated with WR1. The personal factor was single predictor of WR2. The attendees rated WR2 more positively than WR1. The personal factor was crucial for both WR1 and WR2. Work-related factors were only important for WR1. The more negative rating of belief in a future worker role may be interpreted as mistrust in the services. The attendees' positive ratings of capacities indicate, however, that they had a rehabilitation potential to develop. Enhancing self-esteem, mastery and engagement may be an avenue for staff in efforts to support the attendee's worker role.

  11. Light absorbing material (soot) in rainwater and in aerosol particles in the Maldives

    NASA Astrophysics Data System (ADS)

    Granat, L.; EngströM, J. E.; Praveen, S.; Rodhe, H.

    2010-08-01

    Simultaneous measurements of soot (absorbing material at 528 nm) and inorganic ions in aerosol and precipitation at the Maldives Climate Observatory Hanimaadhoo during the period May 2005 to February 2007 have made it possible to calculate the washout ratio (WR) of these components as a measure of how efficiently they are scavenged by precipitation. On the basis of air trajectories the data have been separated into days with polluted air arriving from the Indian subcontinent in a northeasterly sector during winter and clean monsoon days with southerly flow from the Indian Ocean. The average soot concentration was a factor of 10 higher in the former situations. Despite considerable scatter for individual days, a systematic pattern emerged when the WR for the different components were compared with each other. During the monsoon season the WR for soot was similar to that of sulfate and other fine mode aerosol components, indicating that soot containing particles in these situations were efficient as cloud condensation nuclei. The origin of the light absorbing material during the monsoon season is unclear. During the polluted winter days, on the other hand, the WR for soot was three times smaller than that of sulfate. This indicates that, even after a travel time of several days, the soot containing particles from India have retained much of their hydrophobic property. The low WR and the infrequent rain during this season probably contribute to extending the atmospheric lifetime of soot well beyond several days. Surprisingly high concentrations of non-sea-salt calcium were measured during the monsoon season, substantially higher than during the winter season. The origin of these high values could be long-range transport from the Australian or African continents. Another possibility might be exopolymer gels derived from the ocean surface microlayer.

  12. Effects of fresh gas flow, tidal volume, and charcoal filters on the washout of sevoflurane from the Datex Ohmeda (GE) Aisys, Aestiva/5, and Excel 210 SE Anesthesia Workstations.

    PubMed

    Sabouri, A Sassan; Lerman, Jerrold; Heard, Christopher

    2014-10-01

    We investigated the effects of tidal volume (VT), fresh gas flow (FGF), and a charcoal filter in the inspiratory limb on the washout of sevoflurane from the following Datex Ohmeda (GE) Anesthesia Workstations (AWSs): Aisys, Aestiva/5, and Excel 210SE. After equilibrating the AWSs with 2% sevoflurane, the anesthetic was discontinued, and the absorbent anesthesia breathing circuit (ABC), reservoir bag, and test lung were changed. The lung was ventilated with 350 or 200 mL·breath(-1), 15 breaths·min(-1), and a FGF of 10 L·min(-1) while the washout of sevoflurane was performed in triplicate using a calibrated Datex Ohmeda Capnomac Ultima™ and a calibrated MIRAN SapphIRe XL ambient air analyzer until the concentration was ≤ 10 parts per million (ppm). The effects of decreasing the FGF to 5 and 2 L·min(-1) after the initial washout and of a charcoal filter in the ABC were recorded separately. The median washout times with the Aisys AWS (14 min, P < 0.01) and the Aestiva/5 (17 min, P < 0.001) with VT 350 mL·breath(-1) were significantly less than that with the Excel 210SE (32 min). The mean (95% confidence interval) washout time with the Aisys increased to 23.5 (21.5 to 25.5) min with VT 200 mL·breath(-1) (P < 0.01). Decreasing the FGF from 10 to 5 and 2 L·min(-1) with the Aisys caused a rebound in sevoflurane concentration to ≥ 50 ppm. Placement of a charcoal filter in the inspiratory limb reduced the sevoflurane concentration to < 2 ppm in the Aisys and Aestiva/5 AWSs within two minutes. The GE AWSs should be purged with large FGFs and VTs ~350 mL·breath(-1) for ~25 min to achieve 10 ppm sevoflurane. The FGF should be maintained to avoid a rebound in anesthetic concentration. Charcoal filters rapidly decrease the anesthetic concentration to < 2 ppm.

  13. Minimizing atelectasis formation during general anaesthesia—oxygen washout is a non-essential supplement to PEEP

    PubMed Central

    Östberg, Erland; Auner, Udo; Enlund, Mats; Zetterström, Henrik; Edmark, Lennart

    2017-01-01

    Background Following preoxygenation and induction of anaesthesia, most patients develop atelectasis. We hypothesized that an immediate restoration to a low oxygen level in the alveoli would prevent atelectasis formation and improve oxygenation during the ensuing anaesthesia. Methods We randomly assigned 24 patients to either a control group (n = 12) or an intervention group (n = 12) receiving an oxygen washout procedure directly after intubation. Both groups were, depending on body mass index, ventilated with a positive end-expiratory pressure (PEEP) of 6–8 cmH2O during surgery. The atelectasis area was studied by computed tomography before emergence. Oxygenation levels were evaluated by measuring blood gases and calculating estimated venous admixture (EVA). Results The atelectasis areas expressed as percentages of the total lung area were 2.0 (1.5–2.7) (median [interquartile range]) and 1.8 (1.4–3.3) in the intervention and control groups, respectively. The difference was non-significant, and also oxygenation was similar between the two groups. Compared to oxygenation before the start of anaesthesia, oxygenation at the end of surgery was improved in the intervention group, mean (SD) EVA from 7.6% (6.6%) to 3.9% (2.9%) (P = .019) and preserved in the control group, mean (SD) EVA from 5.0% (5.3%) to 5.6% (7.1%) (P = .59). Conclusion Although the oxygen washout restored a low pulmonary oxygen level within minutes, it did not further reduce atelectasis size. Both study groups had small atelectasis and good oxygenation. These results suggest that a moderate PEEP alone is sufficient to minimize atelectasis and maintain oxygenation in healthy patients. PMID:28434271

  14. Minimizing atelectasis formation during general anaesthesia-oxygen washout is a non-essential supplement to PEEP.

    PubMed

    Östberg, Erland; Auner, Udo; Enlund, Mats; Zetterström, Henrik; Edmark, Lennart

    2017-06-01

    Following preoxygenation and induction of anaesthesia, most patients develop atelectasis. We hypothesized that an immediate restoration to a low oxygen level in the alveoli would prevent atelectasis formation and improve oxygenation during the ensuing anaesthesia. We randomly assigned 24 patients to either a control group (n = 12) or an intervention group (n = 12) receiving an oxygen washout procedure directly after intubation. Both groups were, depending on body mass index, ventilated with a positive end-expiratory pressure (PEEP) of 6-8 cmH 2 O during surgery. The atelectasis area was studied by computed tomography before emergence. Oxygenation levels were evaluated by measuring blood gases and calculating estimated venous admixture (EVA). The atelectasis areas expressed as percentages of the total lung area were 2.0 (1.5-2.7) (median [interquartile range]) and 1.8 (1.4-3.3) in the intervention and control groups, respectively. The difference was non-significant, and also oxygenation was similar between the two groups. Compared to oxygenation before the start of anaesthesia, oxygenation at the end of surgery was improved in the intervention group, mean (SD) EVA from 7.6% (6.6%) to 3.9% (2.9%) (P = .019) and preserved in the control group, mean (SD) EVA from 5.0% (5.3%) to 5.6% (7.1%) (P = .59). Although the oxygen washout restored a low pulmonary oxygen level within minutes, it did not further reduce atelectasis size. Both study groups had small atelectasis and good oxygenation. These results suggest that a moderate PEEP alone is sufficient to minimize atelectasis and maintain oxygenation in healthy patients.

  15. Towards a better understanding of the evolution of Wolf-Rayet stars and Type Ib/Ic supernova progenitors

    NASA Astrophysics Data System (ADS)

    Yoon, Sung-Chul

    2017-10-01

    Hydrogen-deficient Wolf-Rayet (WR) stars are potential candidates of Type Ib/Ic supernova (SN Ib/Ic) progenitors and their evolution is governed by mass-loss. Stellar evolution models with the most popular prescription for WR mass-loss rates given by Nugis & Lamers have difficulties in explaining the luminosity distribution of WR stars of WC and WO types and the SN Ic progenitor properties. Here, we suggest some improvements in the WR mass-loss rate prescription and discuss its implications for the evolution of WR stars and SN Ib/Ic progenitors. Recent studies on Galactic WR stars clearly indicate that the mass-loss rates of WC stars are systematically higher than those of WNE stars for a given luminosity. The luminosity and initial metallicity dependences of WNE mass-loss rates are also significantly different from those of WC stars. These factors have not been adequately considered together in previous stellar evolution models. We also find that an overall increase of WR mass-loss rates by about 60 per cent compared to the empirical values obtained with a clumping factor of 10 is needed to explain the most faint WC/WO stars. This moderate increase with our new WR mass-loss rate prescription results in SN Ib/Ic progenitor models more consistent with observations than those given by the Nugis & Lamers prescription. In particular, our new models predict that the properties of SN Ib and SN Ic progenitors are distinctively different, rather than they form a continuous sequence.

  16. Maintaining Adequate CO2 Washout for an Advanced EMU via a New Rapid Cycle Amine Technology

    NASA Technical Reports Server (NTRS)

    Chullen, Cinda; Conger, Bruce

    2012-01-01

    Over the past several years, NASA has realized tremendous progress in Extravehicular Activity (EVA) technology development. This has been evidenced by the progressive development of a new Rapid Cycle Amine (RCA) system for the Advanced Extravehicular Mobility Unit (AEMU) Portable Life Support Subsystem (PLSS). The PLSS is responsible for the life support of the crew member in the spacesuit. The RCA technology is responsible for carbon dioxide (CO2) and humidity control. Another aspect of the RCA is that it is on-back vacuum-regenerable, efficient, and reliable. The RCA also simplifies the PLSS schematic by eliminating the need for a condensing heat exchanger for humidity control in the current EMU. As development progresses on the RCA, it is important that the sizing be optimized so that the demand on the PLSS battery is minimized. As well, maintaining the CO2 washout at adequate levels during an EVA is an absolute requirement of the RCA and associated ventilation system. Testing has been underway in-house at NASA Johnson Space Center and analysis has been initiated to evaluate whether the technology provides exemplary performance in ensuring that the CO2 is removed sufficiently and the ventilation flow is adequate for maintaining CO2 washout in the AEMU spacesuit helmet of the crew member during an EVA. This paper will review the recent developments of the RCA unit, testing planned in-house with a spacesuit simulator, and the associated analytical work along with insights from the medical aspect on the testing. 1

  17. Anticontrol of Hopf bifurcation and control of chaos for a finance system through washout filters with time delay.

    PubMed

    Zhao, Huitao; Lu, Mengxia; Zuo, Junmei

    2014-01-01

    A controlled model for a financial system through washout-filter-aided dynamical feedback control laws is developed, the problem of anticontrol of Hopf bifurcation from the steady state is studied, and the existence, stability, and direction of bifurcated periodic solutions are discussed in detail. The obtained results show that the delay on price index has great influences on the financial system, which can be applied to suppress or avoid the chaos phenomenon appearing in the financial system.

  18. Characterisation and bioactivity of protein-bound polysaccharides from submerged-culture fermentation of Coriolus versicolor Wr-74 and ATCC-20545 strains.

    PubMed

    Cui, Jian; Goh, Kelvin Kim Tha; Archer, Richard; Singh, Harjinder

    2007-05-01

    The protein-bound polysaccharides of Coriolus versicolor (CPS) have been reported to stimulate overall immune functions against cancers and various infectious diseases by activating specific cell functions. A New Zealand isolate (Wr-74) and a patented strain (ATCC-20545) of C. versicolor were compared in this study. The fruit bodies of both strains were grown for visual verification. Both strains were grown in submerged-culture using an airlift fermentor with milk permeate as the base medium supplemented with glucose, yeast extract and salt. Metabolic profiles of both strains obtained over 7-day fermentation showed very similar trends in terms of biomass production (8.9-10.6 mg/ml), amounts of extracellular polysaccharide (EPS) from the culture medium (1150-1132 microg/ml), and intracellular polysaccharide (IPS) from the mycelium (80-100 microg/ml). Glucose was the dominant sugar in both EPS and IPS, and the polymers each consisted of three molecular weight fractions ranging from 2 x 10(6) to 3 x 10(3 )Da. Both the EPS and IPS were able to significantly induce cytokine production (interleukin 12 and gamma interferon) in murine splenocytes in vitro. Highest levels of interleukin 12 (291 pg/ml) and gamma interferon (6,159 pg/ml) were obtained from samples containing Wr-74 IPS (0.06 microg/ml) and ATCC 20545 IPS (0.1 microg/ml), respectively. The results indicated that lower levels of EPS and IPS generally resulted in higher immune responses than did higher polymer concentrations.

  19. Nasal versus face mask for multiple-breath washout technique in preterm infants.

    PubMed

    Schulzke, S M; Deeptha, K; Sinhal, S; Baldwin, D N; Pillow, J J

    2008-09-01

    The large dead space associated with face masks might impede the accuracy and feasibility of multiple-breath washout (MBW) measurements in small infants. We asked if a low dead space nasal mask would provide measurements of resting lung volume and ventilation inhomogeneity comparable to those obtained with a face mask, when using the MBW technique. Unsedated preterm infants breathing without mechanical assistance and weighing between 1.50 and 2.49 kg were studied. Paired MBW tests with nasal and face masks were obtained using sulphur hexafluoride (SF(6)) as the tracer gas. The order of mask application was quasi-randomized. Bland-Altman method and intraclass correlation coefficient were used to analyze outcomes. Measurements were obtained in 20 infants with a mean (SD) postmenstrual age of 36 (1.4) w and a test weight of 2.0 (0.3) kg. The mean difference (95% CI) for nasal vs. face mask was -3.2 breaths/min (-6.2, -0.1 breaths/min) for respiratory rate, -1.0 ml/kg (-2.3, 0.3 ml/kg) for lung volume, 0.6 (0.1, 1.1) for lung clearance index, 0.2 (0.1, 0.3) for first to zeroeth moment ratio and 1.33 (0.6, 2.4) for second to zeroeth moment ratio. Paired measurements of lung volume showed acceptable agreement and good correlation, but there was poor agreement and poor correlation between indices of ventilation inhomogeneity obtained with the two masks. Functional dead space of the nasal mask was similar to that of the face mask despite its smaller water displacement volume. During MBW in infants below 2.5 kg body weight, a nasal mask results in comparable lung volume measurements. Indices of ventilation inhomogeneity may not be directly comparable using masks with different dead space. (c) 2008 Wiley-Liss, Inc.

  20. Cadaveric renal preservation with hyperosmolar, intracellular hypothermic washout solution and cold storage.

    PubMed

    Diethelm, A G; Blackstone, E H

    1978-07-01

    All 54 kidneys obtained from heart-beating cadavers functioned when preserved by a brief washout using a hypothermic, hyperosmolar, hyperkalemic perfusate, followed by cold storage. The duration of preservation ranged from two hours and 57 minutes to 39 hours and 47 minutes. Two other kidneys retrieved from a nonheart-beating cadaver and preserved by the same technique failed to function because of irreversible acute tubular necrosis. Fifty-six consecutive transplant patients were divided into four groups according to the period of preservation. There was no correlation between graft rejection, frequency of post-transplant dialysis, long term graft function and survival time, when the duration of preservation was less than 24 hours. The advantages of this technique included technical simplicity, low cost, minimal risk of graft infection and easy transportation. The two primary disadvantages were an apparent 24 to 30 hour limit of organ preservation with prompt function and the inability to determine intrarenal perfusion pressure during preservation, thereby missing an important parameter of graft viability.

  1. Correction to "A general power equation for predicting bed load transport rates in gravel bed rivers"

    Treesearch

    Jeffrey J. Barry; John M. Buffington; John G. King

    2007-01-01

    In the paper "A general power equation for predicting bed load transport rates in gravel bed rivers" by Jeffrey J. Barry et al. (Water Resources Research, 40, W10401, doi:10.1029/2004WR003190, 2004), the y axis for Figures 5 and 10 was incorrectly labeled and should have read "log10 (predicted transport) - log10 (observed transport)." In addition,...

  2. Special Report on the Data Collection Programs for the Ground Based Nitrogen Washout Experiment. Volume 2 - Detailed Program Descriptions, Listings, Examples and Hardware Specifications

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Personal data input, decompression data, nitrogen washout, nitrogen data, and update computer programs are described. Input data and formats; program output, reports, and data; program flowcharts; program listings; sample runs with input and output pages; hardware operation; and engineering data are provided.

  3. A comparison of data sources for the surveillance of work-related carpal tunnel syndrome in Massachusetts.

    PubMed

    Davis, Letitia; Wellman, Helen; Hart, James; Cleary, Robert; Gardstein, Betsey M; Sciuchetti, Paul

    2004-09-01

    This study examined whether a state surveillance system for work-related carpal tunnel syndrome (WR-CTS) based on workers' compensation claims (Sentinel Event Notification System for Occupational Risks, SENSOR) and the Annual Survey of Occupational Injuries and Illnesses (SOII) identified the same industries, occupations, sources of injury, and populations for intervention. Trends in counts, rates, and female/male ratios of WR-CTS during 1994-1997, and age distributions were compared across three data sources: SENSOR, Massachusetts SOII, and National SOII. SENSOR and National SOII data on WR-CTS were compared by industry, occupation, and injury source. Due to small sample size and subsequent gaps in available information, state SOII data on WR-CTS were of little use in identifying specific industries and occupations for intervention. SENSOR and National SOII data on the frequency of WR-CTS cases identified many similar occupations and industries, and both surveillance systems pointed to computer use as a risk factor for WR-CTS. Some high rate industries identified by SENSOR were not identified using National SOII rates even when national findings were restricted to take into account the distribution of the Massachusetts workforce. Use of national SOII data on rates of WR-CTS for identifying state industry priorities for WR-CTS prevention should be undertaken with caution. Options for improving state SOII data and use of other state data systems should be pursued.

  4. A simple method to reconstruct the molar mass signal of respiratory gas to assess small airways with a double-tracer gas single-breath washout.

    PubMed

    Port, Johannes; Tao, Ziran; Junger, Annika; Joppek, Christoph; Tempel, Philipp; Husemann, Kim; Singer, Florian; Latzin, Philipp; Yammine, Sophie; Nagel, Joachim H; Kohlhäufl, Martin

    2017-11-01

    For the assessment of small airway diseases, a noninvasive double-tracer gas single-breath washout (DTG-SBW) with sulfur hexafluoride (SF 6 ) and helium (He) as tracer components has been proposed. It is assumed that small airway diseases may produce typical ventilation inhomogeneities which can be detected within one single tidal breath, when using two tracer components. Characteristic parameters calculated from a relative molar mass (MM) signal of the airflow during the washout expiration phase are analyzed. The DTG-SBW signal is acquired by subtracting a reconstructed MM signal without tracer gas from the signal measured with an ultrasonic sensor during in- and exhalation of the double-tracer gas for one tidal breath. In this paper, a simple method to determine the reconstructed MM signal is presented. Measurements on subjects with and without obstructive lung diseases including the small airways have shown high reliability and reproducibility of this method.

  5. Isotropic, anisotropic, and borehole washout analyses in Gulf of Mexico Gas Hydrate Joint Industry Project Leg II, Alaminos Canyon well 21-A

    USGS Publications Warehouse

    Lee, Myung W.

    2012-01-01

    Through the use of three-dimensional seismic amplitude mapping, several gas hydrate prospects were identified in the Alaminos Canyon area of the Gulf of Mexico. Two of the prospects were drilled as part of the Gulf of Mexico Gas Hydrate Joint Industry Program Leg II in May 2009, and a suite of logging-while-drilling logs was acquired at each well site. Logging-while-drilling logs at the Alaminos Canyon 21–A site indicate that resistivities of approximately 2 ohm-meter and P-wave velocities of approximately 1.9 kilometers per second were measured in a possible gas-hydrate-bearing target sand interval between 540 and 632 feet below the sea floor. These values are slightly elevated relative to those measured in the hydrate-free sediment surrounding the sands. The initial well log analysis is inconclusive in determining the presence of gas hydrate in the logged sand interval, mainly because large washouts in the target interval degraded well log measurements. To assess gas-hydrate saturations, a method of compensating for the effect of washouts on the resistivity and acoustic velocities is required. To meet this need, a method is presented that models the washed-out portion of the borehole as a vertical layer filled with seawater (drilling fluid). Owing to the anisotropic nature of this geometry, the apparent anisotropic resistivities and velocities caused by the vertical layer are used to correct measured log values. By incorporating the conventional marine seismic data into the well log analysis of the washout-corrected well logs, the gas-hydrate saturation at well site AC21–A was estimated to be in the range of 13 percent. Because gas hydrates in the vertical fractures were observed, anisotropic rock physics models were also applied to estimate gas-hydrate saturations.

  6. Maintaining Adequate CO2 Washout for an Advanced EMU via a New Rapid Cycle Amine Technology

    NASA Technical Reports Server (NTRS)

    Chullen, Cinda

    2011-01-01

    Over the past several years, NASA has realized tremendous progress in Extravehicular Activity (EVA) technology development. This has been evidenced by the progressive development of a new Rapic Cycle Amine (RCA) system for the Advanced Extravehicular Mobility Unit (AEMU) Portable Life Support Subsystem (PLSS). The PLSS is responsible for the life support of the crew member in the spacesuit. The RCA technology is responsible for carbon dioxide (CO2) and humidity control. Another aspect of the RCA is that it is on-back vacuum-regenerable, efficient, and reliable. The RCA also simplifies the PLSS schematic by eliminating the need for a condensing heat exchanger for humidity control in the current EMU. As development progresses on the RCA, it is important that the sizing be optimized so that the demand on the PLSS battery is minimized. As well, maintaining the CO2 washout at adequate levels during an EVA is an absolute requirement of the RCA and associated ventilation system. Testing has been underway in-house at NASA Johnson Space Center and analysis has been initiated to evaluate whether the technology provides exemplary performance in ensuring that the CO2 is removed sufficiently enough and the ventilation flow is adequate enough to maintain CO2 1 Project Engineer, Space Suit and Crew Survival Systems Branch, Crew and Thermal Systems Division, 2101 NASA Parkway, Houston, TX 77058/EC5. washout in the AEMU spacesuit helmet of the crew member during an EVA. This paper will review the recent developments of the RCA unit, the testing results performed in-house with a spacesuit simulator, and the associated analytical work along with insights from the medical aspect on the testing.

  7. A new prescription for the mass-loss rates of hydrogen-free WR stars

    NASA Astrophysics Data System (ADS)

    Tramper, Frank; Sana, Hugues; de Koter, Alex

    2017-11-01

    We present a new empirical prescription for the mass-loss rates of hydrogen-free Wolf-Rayet stars based on results of detailed spectral analyses of WC and WO stars. Compared to the prescription of Nugis & Lamers (2000), M⊙ is less sensitive to the surface helium abundance, implying a stronger mass loss at the late stages of Wolf-Rayet evolution. The winds of hydrogen-free WN stars have a strong metallicity dependence, while those of WC and WO stars have a very weak metallicity dependence.

  8. Dependence of weak interaction rates on the nuclear composition during stellar core collapse

    NASA Astrophysics Data System (ADS)

    Furusawa, Shun; Nagakura, Hiroki; Sumiyoshi, Kohsuke; Kato, Chinami; Yamada, Shoichi

    2017-02-01

    We investigate the influences of the nuclear composition on the weak interaction rates of heavy nuclei during the core collapse of massive stars. The nuclear abundances in nuclear statistical equilibrium (NSE) are calculated by some equation of state (EOS) models including in-medium effects on nuclear masses. We systematically examine the sensitivities of electron capture and neutrino-nucleus scattering on heavy nuclei to the nuclear shell effects and the single-nucleus approximation. We find that the washout of the shell effect at high temperatures brings significant change to weak rates by smoothing the nuclear abundance distribution: the electron capture rate decreases by ˜20 % in the early phase and increases by ˜40 % in the late phase at most, while the cross section for neutrino-nucleus scattering is reduced by ˜15 % . This is because the open-shell nuclei become abundant instead of those with closed neutron shells as the shell effects disappear. We also find that the single-nucleus description based on the average values leads to underestimations of weak rates. Electron captures and neutrino coherent scattering on heavy nuclei are reduced by ˜80 % in the early phase and by ˜5 % in the late phase, respectively. These results indicate that NSE like EOS accounting for shell washout is indispensable for the reliable estimation of weak interaction rates in simulations of core-collapse supernovae.

  9. Evaluation of a linear washout for simulator motion cue presentation during landing approach

    NASA Technical Reports Server (NTRS)

    Parrish, R. V.; Martin, D. J., Jr.

    1975-01-01

    The comparison of a fixed-base versus a five-degree-of-freedom motion base simulation of a 737 conventional take-off and landing (CTOL) aircraft performing instrument landing system (ILS) landing approaches was used to evaluate a linear motion washout technique. The fact that the pilots felt that the addition of motion increased the pilot workload and this increase was not reflected in the objective data results, indicates that motion cues, as presented, are not a contributing factor to root-mean-square (rms) performance during the landing approach task. Subjective results from standard maneuvering about straight-and-level flight for specific motion cue evaluation revealed that the longitudinal channels (pitch and surge) possibly the yaw channel produce acceptable motions. The roll cue representation, involving both roll and sway channels, was found to be inadequate for large roll inputs, as used for example, in turn entries.

  10. Seismic investigation of gas hydrates in the Gulf of Mexico: 2013 multi-component and high-resolution 2D acquisition at GC955 and WR313

    USGS Publications Warehouse

    Haines, Seth S.; Hart, Patrick E.; Shedd, William W.; Frye, Matthew

    2014-01-01

    The U.S. Geological Survey led a seismic acquisition cruise at Green Canyon 955 (GC955) and Walker Ridge 313 (WR313) in the Gulf of Mexico from April 18 to May 3, 2013, acquiring multicomponent and high-resolution 2D seismic data. GC955 and WR313 are established, world-class study sites where high gas hydrate saturations exist within reservoir-grade sands in this long-established petroleum province. Logging-while-drilling (LWD) data acquired in 2009 by the Gulf of Mexico Gas Hydrates Joint Industry Project provide detailed characterization at the borehole locations, and industry seismic data provide regional- and local-scale structural and stratigraphic characterization. Significant remaining questions regarding lithology and hydrate saturation between and away from the boreholes spurred new geophysical data acquisition at these sites. The goals of our 2013 surveys were to (1) achieve improved imaging and characterization at these sites and (2) refine geophysical methods for gas hydrate characterization in other locations. In the area of GC955 we deployed 21 ocean-bottom seismometers (OBS) and acquired approximately 400 km of high-resolution 2D streamer seismic data in a grid with line spacing as small as 50 m and along radial lines that provide source offsets up to 10 km and diverse azimuths for the OBS. In the area of WR313 we deployed 25 OBS and acquired approximately 450 km of streamer seismic data in a grid pattern with line spacing as small as 250 m and along radial lines that provide source offsets up to 10 km for the OBS. These new data afford at least five times better resolution of the structural and stratigraphic features of interest at the sites and enable considerably improved characterization of lithology and the gas and gas hydrate systems. Our recent survey represents a unique application of dedicated geophysical data to the characterization of confirmed reservoir-grade gas hydrate accumulations.

  11. Role of right ventricle and dynamic pulmonary hypertension on determining ΔVO2/ΔWork Rate flattening: insights from cardiopulmonary exercise test combined with exercise echocardiography.

    PubMed

    Bandera, Francesco; Generati, Greta; Pellegrino, Marta; Donghi, Valeria; Alfonzetti, Eleonora; Gaeta, Maddalena; Villani, Simona; Guazzi, Marco

    2014-09-01

    Several cardiovascular diseases are characterized by an impaired O2 kinetic during exercise. The lack of a linear increase of Δoxygen consumption (VO2)/ΔWork Rate (WR) relationship, as assessed by expired gas analysis, is considered an indicator of abnormal cardiovascular efficiency. We aimed at describing the frequency of ΔVO2/ΔWR flattening in a symptomatic population of cardiac patients, characterizing its functional profile, and testing the hypothesis that dynamic pulmonary hypertension and right ventricular contractile reserve play a major role as cardiac determinants. We studied 136 patients, with different cardiovascular diseases, referred for exertional dyspnoea. Cardiopulmonary exercise test combined with simultaneous exercise echocardiography was performed using a symptom-limited protocol. ΔVO2/ΔWR flattening was observed in 36 patients (group A, 26.5% of population) and was associated with a globally worse functional profile (reduced peak VO2, anaerobic threshold, O2 pulse, impaired VE/VCO2). At univariate analysis, exercise ejection fraction, exercise mitral regurgitation, rest and exercise tricuspid annular plane systolic excursion, exercise systolic pulmonary artery pressure, and exercise cardiac output were all significantly (P<0.05) impaired in group A. The multivariate analysis identified exercise systolic pulmonary artery pressure (odds ratio, 1.06; confidence interval, 1.01-1.11; P=0.01) and exercise tricuspid annular plane systolic excursion (odds ratio, 0.88; confidence interval, 0.80-0.97; P=0.01) as main cardiac determinants of ΔVO2/ΔWR flattening; female sex was strongly associated (odds ratio, 6.10; confidence interval, 2.11-17.7; P<0.01). In patients symptomatic for dyspnea, the occurrence of ΔVO2/ΔWR flattening reflects a significantly impaired functional phenotype whose main cardiac determinants are the excessive systolic pulmonary artery pressure increase and the reduced peak right ventricular longitudinal systolic function.

  12. Modelling responses of the inert-gas washout and MRI to bronchoconstriction.

    PubMed

    Foy, Brody H; Kay, David; Bordas, Rafel

    2017-01-01

    Many lung diseases lead to an increase in ventilation heterogeneity (VH). Two clinical practices for the measurement of patient VH are in vivo imaging, and the inert gas multiple breath washout (MBW). In this study computational modelling was used to compare the responses of MBW indices LCI and s cond and MRI measured global and local ventilation indices, σ r and σ local , to constriction of airways in the conducting zone of the lungs. The simulations show that s cond , LCI and σ r behave quite similarly to each other, all being sensitive to increases in the severity of constriction, while exhibiting little sensitivity to the depth at which constriction occurs. In contrast, the local MRI index σ local shows strong sensitivity to depth of constriction, but lowered sensitivity to constriction severity. We finish with an analysis of the sensitivity of MRI indices to grid sizes, showing that results should be interpreted with reference to the image resolution. Overall we conclude that the application of both local and global VH measures may help to classify different types of bronchoconstriction. Copyright © 2016 Elsevier B.V. All rights reserved.

  13. The effect of time-of-day and chest physiotherapy on multiple breath washout measures in children with clinically stable cystic fibrosis.

    PubMed

    Voldby, Christian; Green, Kent; Rosthøj, Susanne; Kongstad, Thomas; Philipsen, Lue; Buchvald, Frederik; Skov, Marianne; Pressler, Tania; Gustafsson, Per; Nielsen, Kim G

    2018-01-01

    In this pilot study we investigated daytime variation of multiple breath nitrogen washout (N2MBW) measures in children with clinically stable cystic fibrosis. To our knowledge the effect of time-of-day on multiple breath washout measures in patients with cystic fibrosis has not previously been reported. Furthermore, we assessed the influence of chest physiotherapy on N2MBW measures. Ten school children with cystic fibrosis performed N2MBW followed by spirometry and plethysmography in the morning and afternoon at three visits that were one month apart. Chest physiotherapy was performed immediately before the afternoon measurements at visit 2 and immediately before morning and afternoon measurements at visit 3. The influence of time-of-day and chest physiotherapy on the measures was evaluated using linear mixed models. There were adequate quality data from 8 children with median age (range) 9.6 (6.0; 15.1) years. Baseline lung clearance index (LCI) (range) was 9.0 (7.1; 13.0) and baseline FEV1% predicted was 97.5 (78.5; 117.9). No N2MBW measures were significantly influenced by time-of-day or chest physiotherapy. LCI (95% confidence interval) decreased non-significantly 0.05 (-0.32; 0.22) during the day and increased non-significantly 0.08 (-0.26; 0.42) after chest physiotherapy. All spirometric measures were unaffected by time-of-day and chest physiotherapy. For plethysmographic measures FRCpleth decreased significantly (p<0.01) 110 mL during the day, whereas a borderline significant (p = 0.046) decrease in ΔFRCpleth-MBW during the day and a borderline significant (p = 0.03) increase in TLC after CPT were observed. This study demonstrated that the time-of-day as well as chest physiotherapy performed immediately prior to N2MBW had no consistent or significant influence on N2MBW measures. However, we emphasize that further studies of the effect of both daytime variation and the effect of chest physiotherapy on multiple breath washout measures are warranted.

  14. Effects of Mass Flow Rate on the Thermal-Flow Characteristics of Microwave CO2 Plasma.

    PubMed

    Hong, Chang-Ki; Na, Young-Ho; Uhm, Han-Sup; Kim, Youn-Jea

    2015-03-01

    In this study, the thermal-flow characteristics of atmospheric pressure microwave CO2 plasma were numerically investigated by simulation. The electric and gas flow fields in the reaction chamber with a microwave axial injection torch operated at 2.45 GHz were simulated. The microwave launcher had the standard rectangular waveguide WR340 geometry. The simulation was performed by using the COMSOL Multiphysics plasma model with various mass flow rates of CO2. The electric fields, temperature profiles and the density of electrons were graphically depicted for different CO2 inlet mass flow rates.

  15. Exposure to Leadership WalkRounds in neonatal intensive care units is associated with a better patient safety culture and less caregiver burnout

    PubMed Central

    Sexton, J Bryan; Sharek, Paul J; Thomas, Eric J; Gould, Jeffrey B; Nisbet, Courtney C; Amspoker, Amber B; Kowalkowski, Mark A; Schwendimann, René; Profit, Jochen

    2014-01-01

    Background Leadership WalkRounds (WR) are widely used in healthcare organisations to improve patient safety. The relationship between WR and caregiver assessments of patient safety culture, and healthcare worker burnout is unknown. Methods This cross-sectional survey study evaluated the association between receiving feedback about actions taken as a result of WR and healthcare worker assessments of patient safety culture and burnout across 44 neonatal intensive care units (NICUs) actively participating in a structured delivery room management quality improvement initiative. Results Of 3294 administered surveys, 2073 were returned for an overall response rate of 62.9%. More WR feedback was associated with better safety culture results and lower burnout rates in the NICUs. Participation in WR and receiving feedback about WR were less common in NICUs than in a benchmarking comparison of adult clinical areas. Conclusions WR are linked to patient safety and burnout. In NICUs, where they occurred more often, the workplace appears to be a better place to deliver and to receive care. PMID:24825895

  16. Diagnosis of vasculogenic impotence: Combination of penile xenon-133 washout and papaverine tests

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lin, S.N.; Liu, R.S.; Yu, P.C.

    1989-07-01

    The present study evaluates both penile xenon-133 washout (XWT) and papaverine tests (PT) in the diagnosis of vasculogenic impotence. XWT was accomplished by subcutaneous injection of xenon-133 (1-2 mCi in 0.1 mL saline solution) into the dorsal coronal prepuce. Abnormal XWT was suggested in patients whose clearance time (T1/2) was longer than 7.5 minutes and whose penile blood flow rate (Q) was less than 6 mL/100 g tissue/min. PT was done by intracavernous injection of papaverine (60 mg in 20 mL normal saline). Abnormal PT was indicated in patients whose onset of full erection was more than ten minutes aftermore » papaverine injection and whose duration of erection was less than one hour. Ten young and 11 older normal volunteers were examined with XWT only; all showed normal results. A total of 60 impotent patients were examined with both XWT and PT and were classified into four groups: in 2 patients (3.3%) both XWT and PT were normal (group I); in 8 (13.3%) XWT was abnormal and PT normal (group II); in 14 (23.3%) XWT was normal and PT abnormal (group III); and in 36 (60%) both XWT and PT were abnormal (group IV). On further examination with bilateral hypogastric arteriography in 10 XWT-abnormal patients and on surgical correction of abnormal curvature in 5 XWT-abnormal patients, all (100%) were proved to have penile arterial insufficiency. Erection cavernosography performed in 15 PT-abnormal patients confirmed penile venous insufficiency in 80 percent. We conclude both XWT and PT are simple and effective for evaluation of the penile arterial blood flow and venous competence, respectively.« less

  17. Ability of the new AT1 receptor blocker azilsartan to block angiotensin II-induced AT1 receptor activation after wash-out.

    PubMed

    Miura, Shin-ichiro; Matsuo, Yoshino; Nakayama, Asuka; Tomita, Sayo; Suematsu, Yasunori; Saku, Keijiro

    2014-03-01

    The recently approved angiotensin II (Ang II) type 1 (AT1) receptor blocker (ARB) azilsartan strongly reduces blood pressure (BP) in patients with hypertension. We previously reported that azilsartan showed unique binding behavior to the AT1 receptor because of its 5-oxo-1,2,4-oxadiazole moiety. However, the ability of azilsartan to block Ang II-dependent AT1 receptor activation is not yet clear. Azilsartan and a derivative of azilsartan (azilsartan-7H) that lacks a carboxyl group at the benzimidazole ring were used. Ang II-induced inositol phosphate (IP) production and extracellular signal-regulated kinase (ERK) activation were analyzed in a cell-based wash-out assay. Azilsartan, but not azilsartan-7H, completely blocked Ang II-induced IP production and ERK activation. Our previous report demonstrated that azilsartan mainly interacts with Tyr(113), Lys(199), and Gln(257) in the AT1 receptor. The interactions between azilsartan and Tyr(113) and Gln(257), but not Lys(199), were critical for blocking Ang II-induced IP production and ERK activation after wash-out. Although our findings regarding the molecule-specific effects of azilsartan are based on basic research, they may lead to an exciting insight into the mechanism of azilsartan.

  18. Leptogenesis constraints on the mass of right-handed gauge bosons

    NASA Astrophysics Data System (ADS)

    Dev, P. S. Bhupal; Lee, Chang-Hun; Mohapatra, R. N.

    2014-11-01

    We discuss leptogenesis constraints on the mass of the right-handed W boson (WR ) in a TeV-scale left-right seesaw model for neutrino masses. For generic Dirac mass of the neutrinos, i.e. with all Yukawa couplings ≲1 0-5.5 , it has been pointed out that successful leptogenesis requires a lower bound of 18 TeV on the WR mass, pushing it beyond the reach of the LHC. Such TeV-scale left-right seesaw model must, however, be parity asymmetric for type-I seesaw to give the observed neutrino masses. This class of models can accommodate larger Yukawa couplings, which give simultaneous fits to charged-lepton and neutrino masses, by invoking either cancellations or specific symmetry textures for Dirac (MD) and Majorana (MN) masses in the seesaw formula. We show that in this case the leptogenesis bound on MWRcan be substantially weaker, i.e. MW R≳3 TeV for MN≲MW R. This happens due to considerable reduction of the dilution effects from WR-mediated decays and scatterings, while the washout effects due to inverse decays are under control for certain parameter ranges of the Yukawa couplings. We also show that this model is consistent with all other low-energy constraints, such as lepton flavor violation and neutrinoless double beta decay. Thus, a discovery of the right-handed gauge bosons alone at the LHC will not falsify leptogenesis as the mechanism behind the matter-antimatter asymmetry in our Universe.

  19. Evaluation of the Appropriate Washout Period Following Fan Therapy for Dyspnea in Patients With Advanced Cancer: A Pilot Study.

    PubMed

    Kako, Jun; Morita, Tatsuya; Yamaguchi, Takuhiro; Sekimoto, Asuko; Kobayashi, Masamitsu; Kinoshita, Hiroya; Ogawa, Asao; Zenda, Sadamoto; Uchitomi, Yosuke; Inoguchi, Hironobu; Matsushima, Eisuke

    2018-02-01

    To clarify the duration required for dyspnea to return to baseline severity after fan therapy, to evaluate whether fan-to-legs therapy or no fan therapy would be a suitable control therapy, and to investigate changes in patients' face surface temperature after fan therapy. In this pilot study, all participants received 3 interventions in the following order: no fan, fan to legs, and fan to face. Participants used a fan for 5 minutes, and they scored their dyspnea at 10-minute intervals for 60 minutes or until the score had returned to its baseline value, whichever occurred first. Nine patients with advanced cancer admitted to a palliative care unit were included; they had dyspnea at rest and rated its severity as at least 3 points on a 0- to 10-point numerical rating scale. Descriptive statistics and the Wilcoxon signed rank test were used to analyze the data. All patients completed the study. Of the 9 participants, 6 experienced a clinical benefit from using a fan to their faces. Of these patients, only 2 participants' (2 of 6) dyspnea scores returned to baseline by the end of the 60-minute assessment period after exposure to fan-to-face therapy. In fan-to-legs and no fan settings, there was no change in the dyspnea scores. There were significant differences between the baseline face surface temperature and that after fan-to-face and fan-to-legs settings. When using a crossover design to investigate the effect of fan therapy on dyspnea, 1 hour is an insufficient washout period.

  20. Technical note: adipose tissue blood flow in miniature swine (Sus scrofa) using the 133xenon washout technique.

    PubMed

    Moher, H E; Carey, G B

    2002-05-01

    The purpose of this study was to examine the 133xenon washout technique as a viable method for measuring adipose tissue blood flow (ATBF) in swine. Using a total of 32 female Yucatan miniature swine (Sus scrofa), the partition coefficient for 133xenon in swine subcutaneous adipose tissue was determined and ATBF was measured at rest and under various physiological conditions. These conditions included feeding, anesthesia, epinephrine infusion, and acute exercise. The effects of epinephrine and acute exercise were examined in both sedentary and exercise-trained swine. The partition coefficient value for 133xenon in swine subcutaneous adipose tissue was 9.23+/-0.26 mL/g (mean +/- SD, n = 10). The average value for resting ATBF in swine was 3.98+/-2.72 mL/(100 g tissue-min) (n = 19). Feeding increased ATBF by approximately fivefold over fasting values, and isoflurane anesthesia significantly decreased ATBF compared to rest (1.64+/-1.12 vs 3.92+/-4.22 mL/[100 g x min], n = 10). A 30-min epinephrine infusion (1 microg/[kg BW x min]) significantly increased ATBF from a resting value of 3.13+/-2.61 to 10.35+/-5.31 mL/(100 g x min) (n = 12). Epinephrine infusion into exercise-trained swine increased ATBF to the same extent as when infused into sedentary swine. An acute, 20-min bout of exercise significantly increased ATBF in swine, and the sedentary swine showed a larger increase in ATBF than their exercise-trained littermates relative to rest: 7.83 vs 2.98 mL/(100 g x min). In conclusion, the 133xenon washout technique appears to be a viable method for measuring ATBF in swine; our findings are comparable to swine ATBF values reported using the microsphere method and are consistent with values reported in animal and human studies.

  1. Tracing WR wind structures by using the orbiting companion in the 29d WC8d + O8-9IV binary CV Ser

    NASA Astrophysics Data System (ADS)

    David-Uraz, Alexandre; Moffat, Anthony F. J.; Chené, André Nicolas; Lange, Nicholas

    2011-01-01

    We have obtained continuous, high-precision, broadband visible photometry from the MOST satellite of CV Ser over more than a full orbit in order to link the small-scale light-curve variations to extinction due to wind structures in the WR component, thus permitting us to trace these structures. The light-curve presented unexpected characteristics, in particular eclipses with a varying depth. Parallel optical spectroscopy from the Mont Megantic Observatory and Dominion Astrophysical Observatory was obtained to refine the orbital and wind-collision parameters, as well as to reveal line emission from clumps.

  2. Hypolipidemic activity of Phellinus rimosus against triton WR-1339 and high cholesterol diet induced hyperlipidemic rats.

    PubMed

    Rony, K A; Ajith, T A; Nima, N; Janardhanan, K K

    2014-03-01

    Patients with the risk for atherosclerotic disease will be targeted to reduce the existing hyperlipidemia. The hypolipidemic activity of Phellinus rimosus was studied using triton WR-1339 and high cholesterol diet (HCD) induced models. The triton induced elevated lipid profile was attenuated by P. rimosus or standard drug atorvastatin. Similarly, administration of P. rimosus along with HCD significantly decline serum triglyceride, total cholesterol, low-density lipoprotein, with elevating the high-density lipoprotein. Thiobarbituric acid reacting substances in heart and liver significantly decreased; where as activity of enzymatic antioxidants and level of reduced glutathione were significantly increased. In both models, P. rimosus extract showed a significant ameliorative effect on the elevated atherogenic index as well as LDL/HDL-C ratio. The hypolipidemic activity of P. rimosus can be ascribed to its inhibitory effect on the liver HMG CoA reductase activity. The results suggest the possible therapeutic potential of this fungus as hypolipidemic agent. Copyright © 2014 Elsevier B.V. All rights reserved.

  3. Effect of cement washout on loosening of abutment screws and vice versa in screw- and cement- retained implant-supported dental prosthesis

    PubMed Central

    Kim, Seok-Gyu; Son, Mee-Kyoung

    2015-01-01

    PURPOSE The purpose of this study was to examine the abutment screw stability of screw- and cement-retained implant-supported dental prosthesis (SCP) after simulated cement washout as well as the stability of SCP cements after complete loosening of abutment screws. MATERIALS AND METHODS Thirty-six titanium CAD/CAM-made implant prostheses were fabricated on two implants placed in the resin models. Each prosthesis is a two-unit SCP: one screw-retained and the other cemented. After evaluating the passive fit of each prosthesis, all implant prostheses were randomly divided into 3 groups: screwed and cemented SCP (Control), screwed and noncemented SCP (Group 1), unscrewed and cemented SCP (Group 2). Each prosthesis in Control and Group 1 was screwed and/or cemented, and the preloading reverse torque value (RTV) was evaluated. SCP in Group 2 was screwed and cemented, and then unscrewed (RTV=0) after the cement was set. After cyclic loading was applied, the postloading RTV was measured. RTV loss and decementation ratios were calculated for statistical analysis. RESULTS There was no significant difference in RTV loss ratio between Control and Group 1 (P=.16). No decemented prosthesis was found among Control and Group 2. CONCLUSION Within the limits of this in vitro study, the stabilities of SCP abutment screws and cement were not significantly changed after simulated cement washout or screw loosening. PMID:26140172

  4. Results from Carbon Dioxide Washout Testing Using a Suited Manikin Test Apparatus with a Space Suit Ventilation Test Loop

    NASA Technical Reports Server (NTRS)

    Chullen, Cinda; Conger, Bruce; McMillin, Summer; Vonau, Walt; Kanne, Bryan; Korona, Adam; Swickrath, Mike

    2016-01-01

    NASA is developing an advanced portable life support system (PLSS) to meet the needs of a new NASA advanced space suit. The PLSS is one of the most critical aspects of the space suit providing the necessary oxygen, ventilation, and thermal protection for an astronaut performing a spacewalk. The ventilation subsystem in the PLSS must provide sufficient carbon dioxide (CO2) removal and ensure that the CO2 is washed away from the oronasal region of the astronaut. CO2 washout is a term used to describe the mechanism by which CO2 levels are controlled within the helmet to limit the concentration of CO2 inhaled by the astronaut. Accumulation of CO2 in the helmet or throughout the ventilation loop could cause the suited astronaut to experience hypercapnia (excessive carbon dioxide in the blood). A suited manikin test apparatus (SMTA) integrated with a space suit ventilation test loop was designed, developed, and assembled at NASA in order to experimentally validate adequate CO2 removal throughout the PLSS ventilation subsystem and to quantify CO2 washout performance under various conditions. The test results from this integrated system will be used to validate analytical models and augment human testing. This paper presents the system integration of the PLSS ventilation test loop with the SMTA including the newly developed regenerative Rapid Cycle Amine component used for CO2 removal and tidal breathing capability to emulate the human. The testing and analytical results of the integrated system are presented along with future work.

  5. Blood flow regulation and oxygen uptake during high-intensity forearm exercise.

    PubMed

    Nyberg, S K; Berg, O K; Helgerud, J; Wang, E

    2017-04-01

    The vascular strain is very high during heavy handgrip exercise, but the intensity and kinetics to reach peak blood flow, and peak oxygen uptake, are uncertain. We included 9 young (25 ± 2 yr) healthy males to evaluate blood flow and oxygen uptake responses during continuous dynamic handgrip exercise with increasing intensity. Blood flow was measured using Doppler-ultrasound, and venous blood was drawn from a deep forearm vein to determine arteriovenous oxygen difference (a-vO 2diff ) during 6-min bouts of 60, 80, and 100% of maximal work rate (WR max ), respectively. Blood flow and oxygen uptake increased ( P < 0.05) from 60%WR max [557 ± 177(SD) ml/min; 56.0 ± 21.6 ml/min] to 80%WR max (679 ± 190 ml/min; 70.6 ± 24.8 ml/min), but no change was seen from 80%WR max to 100%WR max Blood velocity (49.5 ± 11.5 to 58.1 ± 11.6 cm/s) and brachial diameter (0.49 ± 0.05 to 0.50 ± 0.06 cm) showed concomitant increases ( P < 0.05) with blood flow from 60% to 80%WR max, whereas no differences were observed in a-vO 2diff Shear rate also increased ( P < 0.05) from 60% (822 ± 196 s -1 ) to 80% (951 ± 234 s -1 ) of WR max The mean response time (MRT) was slower ( P < 0.05) for blood flow (60%WR max 50 ± 22 s; 80%WR max 51 ± 20 s; 100%WR max 51 ± 23 s) than a-vO 2diff (60%WR max 29 ± 9 s; 80%WR max 29 ± 5 s; 100%WR max 20 ± 5 s), but not different from oxygen uptake (60%WR max 44 ± 25 s; 80%WR max 43 ± 14 s; 100%WR max 41 ± 32 s). No differences were observed in MRT for blood flow or oxygen uptake with increased exercise intensity. In conclusion, when approaching maximal intensity, oxygen uptake appeared to reach a critical level at ~80% of WR max and be regulated by blood flow. This implies that high, but not maximal, exercise intensity may be an optimal stimulus for shear stress-induced small muscle mass training adaptations. NEW & NOTEWORTHY This study evaluated blood flow regulation and oxygen uptake during small muscle mass forearm exercise with high to

  6. Impact of Software Settings on Multiple-Breath Washout Outcomes.

    PubMed

    Summermatter, Selina; Singer, Florian; Latzin, Philipp; Yammine, Sophie

    2015-01-01

    Multiple-breath washout (MBW) is an attractive test to assess ventilation inhomogeneity, a marker of peripheral lung disease. Standardization of MBW is hampered as little data exists on possible measurement bias. We aimed to identify potential sources of measurement bias based on MBW software settings. We used unprocessed data from nitrogen (N2) MBW (Exhalyzer D, Eco Medics AG) applied in 30 children aged 5-18 years: 10 with CF, 10 formerly preterm, and 10 healthy controls. This setup calculates the tracer gas N2 mainly from measured O2 and CO2concentrations. The following software settings for MBW signal processing were changed by at least 5 units or >10% in both directions or completely switched off: (i) environmental conditions, (ii) apparatus dead space, (iii) O2 and CO2 signal correction, and (iv) signal alignment (delay time). Primary outcome was the change in lung clearance index (LCI) compared to LCI calculated with the settings as recommended. A change in LCI exceeding 10% was considered relevant. Changes in both environmental and dead space settings resulted in uniform but modest LCI changes and exceeded >10% in only two measurements. Changes in signal alignment and O2 signal correction had the most relevant impact on LCI. Decrease of O2 delay time by 40 ms (7%) lead to a mean LCI increase of 12%, with >10% LCI change in 60% of the children. Increase of O2 delay time by 40 ms resulted in mean LCI decrease of 9% with LCI changing >10% in 43% of the children. Accurate LCI results depend crucially on signal processing settings in MBW software. Especially correct signal delay times are possible sources of incorrect LCI measurements. Algorithms of signal processing and signal alignment should thus be optimized to avoid susceptibility of MBW measurements to this significant measurement bias.

  7. Progress in joining, reuse, and customization of WR284 waveguide in the laboratory

    NASA Astrophysics Data System (ADS)

    Clark, Mike; Flanagan, Ken; Milhone, Jason; Nonn, Paul; Forest, Cary

    2017-10-01

    A system of five 20 kW magnetrons is being installed for the Big Red Ball (BRB) to produce and heat the plasma with 2.45GHz RF energy. An existing system of two 6 kW magentrons of the same frequency is actively used for the same purpose on Plasma Couette Experiment Upgrade (PCX-U). In each experiment, the RF is transmitted to the vessel via WR284 waveguide. Waveguide occasionally needs to be disassembled, modified and rebuilt for different reasons such as physics interests, ongoing problems (arcing), or efficient utilization of laboratory space. Reuse of disassembled waveguide parts is desirable for cost savings. Methods of assembly, disassembly, and modification of waveguide will be discussed. Also, frequently used designs of chokes, windows, and limiters will be shown. Materials used include copper, brass, and even aluminum. The vacuum vessel of PCX-U is a 1 meter diameter, 1 meter tall cylinder comprised of ¼'' thick stainless steel. PCX-U has one removable end. The vacuum vessel of the BRB is a 3 meter diameter, sphere comprised of two hemispheres of 1-¼'' thick cast A356 aluminum. Rings comprised of hundreds of SmCo magnets in each vessel create a cusp field to contain the plasma and provide a resonance surface for the RF. Supported by NSF and DoE.

  8. Comparison of low-abundance biomarker levels in capillary-collected nonstimulated tears and washout tears of aqueous-deficient and normal patients.

    PubMed

    Guyette, Nicole; Williams, Larezia; Tran, My-Tho; Than, Tammy; Bradley, John; Kehinde, Lucy; Edwards, Clara; Beasley, Mark; Fullard, Roderick

    2013-05-01

    Low tear volume limits the use of nonstimulated (NS) microcapillary tear collection in aqueous-deficient (AD) patients. Adding a small amount of "washout" fluid to the eye prior to tear collection is a potentially viable alternative method for abundant proteins, but is relatively untested for low-abundance biomarkers. This study determined the feasibility of the washout (WO) method as an NS alternative for low-abundance biomarkers. NS and WO biomarker profiles were compared between AD patients and non-AD controls to determine if the two methods identify the same intergroup differences. Matching NS and WO tears were collected from 48 patients by micropipette, the WO sample after instillation of 10 μL saline. Tear cytokine levels were measured by 27-Plex Bio-Rad assay. Bland-Altman analyses for each biomarker determined the agreement between tear sample types. Patients were grouped as AD or non-AD based on Schirmer score to determine if NS profile between-group differences were preserved in WO tears. Bland-Altman plots showed good biomarker level agreement between NS and WO tears for most cytokines. Five biomarkers, among those most often cited as differing in AD dry eye, differed significantly between non-AD and AD groups in both tear types. Additional biomarker differences were seen in NS tears only. The WO tear collection method is a viable alternative to NS tears for many low-abundance biomarkers and is able to replicate major NS tear differences between dry eye groups. More subtle intergroup differences are lost in WO samples because of reduced statistical power.

  9. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Golubev, A.; Balashov, Y.; Mavrin, S.

    Washout coefficient Λ is widely used as a parameter in washout models. These models describes overall HTO washout with rain by a first-order kinetic equation, while washout coefficient Λ depends on the type of rain event and rain intensity and empirical parameters a, b. The washout coefficient is a macroscopic parameter and we have considered in this paper its relationship with a microscopic rate K of HTO isotopic exchange in atmospheric humidity and drops of rainwater. We have shown that the empirical parameters a, b can be represented through the rain event characteristics using the relationships of molecular impact rate,more » rain intensity and specific rain water content while washout coefficient Λ can be represented through the exchange rate K, rain intensity, raindrop diameter and terminal raindrop velocity.« less

  10. Probing leptogenesis

    NASA Astrophysics Data System (ADS)

    Chun, E. J.; Cvetič, G.; Dev, P. S. B.; Drewes, M.; Fong, C. S.; Garbrecht, B.; Hambye, T.; Harz, J.; Hernández, P.; Kim, C. S.; Molinaro, E.; Nardi, E.; Racker, J.; Rius, N.; Zamora-Saa, J.

    2018-02-01

    The focus of this paper lies on the possible experimental tests of leptogenesis scenarios. We consider both leptogenesis generated from oscillations, as well as leptogenesis from out-of-equilibrium decays. As the Akhmedov-Rubakov-Smirnov (ARS) mechanism allows for heavy neutrinos in the GeV range, this opens up a plethora of possible experimental tests, e.g. at neutrino oscillation experiments, neutrinoless double beta decay, and direct searches for neutral heavy leptons at future facilities. In contrast, testing leptogenesis from out-of-equilibrium decays is a quite difficult task. We comment on the necessary conditions for having successful leptogenesis at the TeV-scale. We further discuss possible realizations and their model specific testability in extended seesaw models, models with extended gauge sectors, and supersymmetric leptogenesis. Not being able to test high-scale leptogenesis directly, we present a way to falsify such scenarios by focusing on their washout processes. This is discussed specifically for the left-right symmetric model and the observation of a heavy WR, as well as model independently when measuring ΔL = 2 washout processes at the LHC or neutrinoless double beta decay.

  11. Insights into Gulf of Mexico Gas Hydrate Study Sites GC955 and WR313 from New Multicomponent and High-Resolution 2D Seismic Data

    NASA Astrophysics Data System (ADS)

    Haines, S. S.; Hart, P. E.; Collett, T. S.; Shedd, W. W.; Frye, M.

    2014-12-01

    In 2013, the U.S. Geological Survey led a seismic acquisition expedition in the Gulf of Mexico, acquiring multicomponent data and high-resolution 2D multichannel seismic (MCS) data at Green Canyon 955 (GC955) and Walker Ridge 313 (WR313). Based on previously collected logging-while-drilling (LWD) borehole data, these gas hydrate study sites are known to include high concentrations of gas hydrate within sand layers. At GC955 our new 2D data reveal at least three features that appear to be fluid-flow pathways (chimneys) responsible for gas migration and thus account for some aspects of the gas hydrate distribution observed in the LWD data. Our new data also show that the main gas hydrate target, a Pleistocene channel/levee complex, has an areal extent of approximately 5.5 square kilometers and that a volume of approximately 3 x 107 cubic meters of this body lies within the gas hydrate stability zone. Based on LWD-inferred values and reasonable assumptions for net sand, sand porosity, and gas hydrate saturation, we estimate a total equivalent gas-in-place volume of approximately 8 x 108 cubic meters for the inferred gas hydrate within the channel/levee deposits. At WR313 we are able to map the thin hydrate-bearing sand layers in considerably greater detail than that provided by previous data. We also can map the evolving and migrating channel feature that persists in this area. Together these data and the emerging results provide valuable new insights into the gas hydrate systems at these two sites.

  12. Bayesian modelling of lung function data from multiple-breath washout tests.

    PubMed

    Mahar, Robert K; Carlin, John B; Ranganathan, Sarath; Ponsonby, Anne-Louise; Vuillermin, Peter; Vukcevic, Damjan

    2018-05-30

    Paediatric respiratory researchers have widely adopted the multiple-breath washout (MBW) test because it allows assessment of lung function in unsedated infants and is well suited to longitudinal studies of lung development and disease. However, a substantial proportion of MBW tests in infants fail current acceptability criteria. We hypothesised that a model-based approach to analysing the data, in place of traditional simple empirical summaries, would enable more efficient use of these tests. We therefore developed a novel statistical model for infant MBW data and applied it to 1197 tests from 432 individuals from a large birth cohort study. We focus on Bayesian estimation of the lung clearance index, the most commonly used summary of lung function from MBW tests. Our results show that the model provides an excellent fit to the data and shed further light on statistical properties of the standard empirical approach. Furthermore, the modelling approach enables the lung clearance index to be estimated by using tests with different degrees of completeness, something not possible with the standard approach. Our model therefore allows previously unused data to be used rather than discarded, as well as routine use of shorter tests without significant loss of precision. Beyond our specific application, our work illustrates a number of important aspects of Bayesian modelling in practice, such as the importance of hierarchical specifications to account for repeated measurements and the value of model checking via posterior predictive distributions. Copyright © 2018 John Wiley & Sons, Ltd.

  13. A model for the global Wolf-Rayet population of the Milky Way

    NASA Astrophysics Data System (ADS)

    Rosslowe, Christopher K.; Crowther, Paul A.

    2013-06-01

    Prompted by the rapidly increasing discovery rate of Galactic Wolf-Rayet stars, we have produced a new near-IR absolute magnitude-spectral subtype calibration from Wolf-Rayet stars at known distances (mostly via cluster membership). We combine this with the relative distribution of WR subtypes for the inner disk, solar circle, and outer disk to model the global WR population in the Milky Way. We adopt the observed vertical scale height of known WR stars plus the measured spatial distribution of dust to produce an expected variation in apparent near-IR magnitudes, of relevance to future spectroscopic surveys. Finally, we use our model apparent magnitude distribution to quantify the total Galactic WR population, and compare this total to expectations from various star formation rate indicators.

  14. A brief Oligocene period of flood volcanism in Yemen: implications for the duration and rate of continental flood volcanism at the Afro-Arabian triple junction

    NASA Astrophysics Data System (ADS)

    Baker, Joel; Snee, Lawrence; Menzies, Martin

    1996-02-01

    40Ar/39Ar dating of mineral separates and whole-rock (WR) samples has established that basaltic continental flood volcanism (CFV) began between 30.9 and 29.2 Ma in northwestern and southwestern Yemen, respectively. Rhyolitic volcanism commenced at 29.0-29.3 Ma throughout Yemen. Lower basaltic lavas were erupted every 10-100 kyr, whereas upper bimodal volcanic units were erupted every 100-500 kyr, which reflects generation of rhyolitic magmas from basalts that resided for longer periods in lithospheric magma chambers than during the early phase of exclusively mafic magmatism. The youngest dated flood volcanic units were erupted between 26.9 and 26.5 Ma throughout Yemen. The duration of preserved CFV defined by 40Ar/39Ar dating (4.4 myr) contrasts with the wide range of WR KAr dates previously obtained in Yemen (> 50 myr). 40Ar/39Ar step-heating studies of WR samples has shown that this discrepancy is due to the disturbed Ar systematics of volcanic samples. Most samples have experienced post-crystallization loss of radiogenic Ar and/or contain excess Ar, with only ca. 25% of the WR KAr dates within 1-2 myr of true crystallization ages. WR KAr data can be screened for reliability using the radiogenic Ar yield and 40K/36Ar ratio, which reflect the Ar retentivity of the sample, the likelihood that alteration has disturbed a sample's Ar systematics, and the susceptibility of the sample to a finite amount of Ar loss or the presence of a finite amount of excess Ar. Examination of existing WR KAr data in the Ethiopian part of this flood volcanic province, using these parameters, suggests that much of these data are also misleading. Two phases of flood volcanism are inferred in Ethiopia and Eritrea at 38-30 Ma and ca. 20 Ma. The older phase is equivalent to that in Yemen, and is consistent with the progression in basal volcanic ages obtained in Yemen moving from north to south. The younger phase is related to the onset of upper crustal extension and incipient Red

  15. A brief Oligocene period of flood volcanism in Yemen: Implications for the duration and rate of continental flood volcanism at the Afro-Arabian triple junction

    USGS Publications Warehouse

    Baker, J.; Snee, L.; Menzies, M.

    1996-01-01

    40Ar39Ar dating of mineral separates and whole-rock (WR) samples has established that basaltic continental flood volcanism (CFV) began between 30.9 and 29.2 Ma in northwestern and southwestern Yemen, respectively. Rhyolitic volcanism commenced at 29.3-29.0 Ma throughout Yemen. Lower basaltic lavas were erupted every 10-100 kyr, whereas upper bimodal volcanic units were erupted every 100-500 kyr, which reflects generation of rhyolitic magmas from basalts that resided for longer periods in lithospheric magma chambers than during the early phase of exclusively mafic magmatism. The youngest dated flood volcanic units were erupted between 26.9 and 26.5 Ma throughout Yemen. The duration of preserved CFV defined by 40Ar/39Ar dating (4.4 myr) contrasts with the wide range of WR K-Ar dates previously obtained in Yemen (> 50 myr). 40Ar/39Ar step-heating studies of WR samples has shown that this discrepancy is due to the disturbed Ar systematics of volcanic samples. Most samples have experienced post-crystallization loss of radiogenic Ar and/or contain excess Ar, with only ca. 25% of the WR K-Ar dates within 1-2 myr of true crystallization ages. WR K-Ar data can be screened for reliability using the radiogenic Ar yield and 40K/36Ar ratio, which reflect the Ar retentivity of the sample, the likelihood that alteration has disturbed a sample's Ar systematics, and the susceptibility of the sample to a finite amount of Ar loss or the presence of a finite amount of excess Ar. Examination of existing WR K-Ar data in the Ethiopian part of this flood volcanic province, using these parameters, suggests that much of these data are also misleading. Two phases of flood volcanism are inferred in Ethiopia and Eritrea at 38-30 Ma and ca. 20 Ma. The older phase is equivalent to that in Yemen, and is consistent with the progression in basal volcanic ages obtained in Yemen moving from north to south. The younger phase is related to the onset of upper crustal extension and incipient Red Sea

  16. A novel sidestream ultrasonic flow sensor for multiple breath washout in children.

    PubMed

    Fuchs, Susanne I; Sturz, J; Junge, S; Ballmann, M; Gappa, M

    2008-08-01

    Inert gas multiple breath washout (MBW) for measuring Lung Clearance Index using mass spectrometry and 4% sulfur hexafluoride (SF(6)) as the tracer gas has been shown to be sensitive for detecting early Cystic Fibrosis (CF) lung disease. However, mass spectrometry requires bulky equipment and is expensive to buy and maintain. A novel sidestream ultrasonic device may overcome this problem. The aims of this study were to assess the feasibility and clinical validity of measuring lung volume (functional residual capacity, FRC) and the LCI using the sidestream ultrasonic flow sensor in children and adolescents with CF in relation to spirometry and plain chest radiographs. MBW using the sidestream ultrasonic device and conventional spirometry were performed in 26 patients with CF and 22 healthy controls. In the controls (4.7-17.7 years) LCI was similar to that reported using mass spectrometry (mean (SD) 6.7 (0.5)). LCI was elevated in 77% of the CF children (6.8-18.9 years), whereas spirometry was abnormal in only 38.5%, 61.5%, and 26.9% for FEV(1), MEF(25), and FEV(1)/FVC, respectively. This was more marked in children <10 years. LCI correlated with the Crispin-Norman score, whereas FEV(1) did not. Sidestream ultrasonic MBW is a valid and simple alternative to mass spectrometry for assessing ventilation homogeneity in children. (c) 2008 Wiley-Liss, Inc.

  17. Early detection of cystic fibrosis lung disease: multiple‐breath washout versus raised volume tests

    PubMed Central

    Lum, Sooky; Gustafsson, Per; Ljungberg, Henrik; Hülskamp, Georg; Bush, Andrew; Carr, Siobhán B; Castle, Rosemary; Hoo, Ah‐fong; Price, John; Ranganathan, Sarath; Stroobant, John; Wade, Angie; Wallis, Colin; Wyatt, Hilary; Stocks, Janet

    2007-01-01

    Background Lung clearance index (LCI), a measure of ventilation inhomogeneity derived from the multiple‐breath inert gas washout (MBW) technique, has been shown to detect abnormal lung function more readily than spirometry in preschool children with cystic fibrosis, but whether this holds true during infancy is unknown. Objectives To compare the extent to which parameters derived from the MBW and the raised lung volume rapid thoraco–abdominal compression (RVRTC) techniques identify diminished airway function in infants with cystic fibrosis when compared with healthy controls. Methods Measurements were performed during quiet sleep, with the tidal breathing MBW technique being performed before the forced expiratory manoeuvres. Results Measurements were obtained in 39 infants with cystic fibrosis (mean (SD) age 41.4 (22.0) weeks) and 21 controls (37.0 (15.1) weeks). Infants with cystic fibrosis had a significantly higher respiratory rate (38 (10) vs 32 (5) bpm) and LCI (8.4 (1.5) vs 7.2 (0.3)), and significantly lower values for all forced expiratory flow‐volume parameters compared with controls. Girls with cystic fibrosis had significantly lower forced expiratory volume (FEV0.5 and FEF25–75 ) than boys (mean (95% CI girls–boys): –1.2 (–2.1 to −0.3) for FEV0.5 Z score; FEF25–75: –1.2 (–2.2 to −0.15)). When using both the MBW and RVRTC techniques, abnormalities were detected in 72% of the infants with cystic fibrosis, with abnormalities detected in 41% using both techniques and a further 15% by each of the two tests performed. Conclusions These findings support the view that inflammatory and/or structural changes in the airways of children with cystic fibrosis start early in life, and have important implications regarding early detection and interventions. Monitoring of early lung disease and functional status in infants and young children with cystic fibrosis may be enhanced by using both MBW and the RVRTC. PMID:17121870

  18. The X-ray monitoring of the long-period colliding wind binaries

    NASA Astrophysics Data System (ADS)

    Sugawara, Y.; Maeda, Y.; Tsuboi, Y.

    2017-10-01

    We present the first results from XMM-Newton and Swift observations of two long-period colliding wind binaries WR19 and WR125 around periastron passages. Mass-loss is one of the most important and uncertain parameters in the evolution of a massive star. The X-ray spectrum off the colliding wind binary is the best measure of conditions in the hot postshock gas. By monitoring the changing of the X-ray luminosity and column density along with the orbital phases, we derive the mass-loss rates of these stars. It is known that WR19 (WC5+O9; P=10.1 yr) and WR125 (WC7+O9; P> 24.3 yr) are the dust-making binaries. Each periastron is expected to come in 2016-2017. Since 2016, we carry out on-going monitoring campaigns of WR19 and WR125 with XMM-Newton and Swift. On these observations, the X-rays from WR19 and WR125 were detected for the first time. In the case of WR19, as periastron approached, the column density increased, which indicates that the emission from the wind-wind collision plasma was absorbed by the dense Wolf-Rayet wind.

  19. 2009: A Colliding-Wind Odyssey

    NASA Astrophysics Data System (ADS)

    Fahed, R.; Moffat, A. F. J.; Zorec, J.; Eversberg, T.; Chené, A. N.; Alves, F.; Arnold, W.; Bergmann, T.; Corcoran, M. F.; Correia Viegas, N. G.; Dougherty, S. M.; Fernando, A.; Frémat, Y.; Gouveia Carreira, L. F.; Hunger, T.; Knapen, J. H.; Leadbeater, R.; Marques Dias, F.; Martayan, C.; Morel, T.; Pittard, J. M.; Pollock, A. M. T.; Rauw, G.; Reinecke, N.; Ribeiro, J.; Romeo, N.; Sánchez-Gallego, J. R.; dos Santos, E. M.; Schanne, L.; Stahl, O.; Stober, Ba.; Stober, Be.; Vollmann, K.; Williams, P. M.

    2012-12-01

    We present the results from two optical spectroscopic campaigns on colliding-wind binaries (CWB) which both occurred in 2009. The first one was on WR 140 (WC7pd + O5.5fc), the archetype of CWB, which experienced periastron passage of its highly elliptical 8-year orbit in January. The WR 140 campaign consisted of a unique and constructive collaboration between amateur and professional astronomers and took place at half a dozen locations, including Teide Observatory, Observatoire de Haute Provence, Dominion Astrophysical Observatory, Observatoire du Mont-Mégantic and at several small private observatories. The second campaign was on a selection of 5 short-period WR + O binaries not yet studied for colliding-wind effects: WR 12 (WN8h), WR 21 (WN5o + O7 V), WR 30 (WC6 + O7.5 V), WR 31 (WN4o + O8), and WR 47 (WN6o + O5). The campaign took place at Leoncito Observatory, Argentina, during 1 month. We provide updated values of most of these systems for the orbital parameters, new estimates for the WR and O star masses and new constraints on the mass-loss rates and colliding wind geometry.

  20. The WR/LBV system HD 5980 in the Small Magellanic Cloud: What is its evolutionary status?

    NASA Astrophysics Data System (ADS)

    Koenigsberger, Gloria; Morrell, Nidia; Hillier, D. John; Barba, Rodolfo; Gamen, Roberto

    2013-06-01

    HD 5980 is located in the Small Magellanic Cloud and consists of two binary systems which, if physically associated, are very widely separated. Their orbital periods are 19.3d and 97d and each of these systems contains very luminous massive stars. The P=19.3d binary is peculiar in that it consists of two WR stars, one of which underwent an LBV eruption in 1994. Because this binary is eclipsing and because it has been monitored since the 1950s, we now have a good grasp on the fundamental parameters of the LBV component. Particularly noteworthy is the fact that its bolometric luminosity increased during the 1994 eruption. In this poster we will summarize our current knowledge of HD 5980, including recent results derived from observations at Las Campanas Observatory which yield an improved orbital solution for the two binary systems and strong limits on the mass of the LBV. With these data, it should now be possible to constrain the evolutionary path that has been followed by the LBV and speculate on its properties as it approaches the supernova stage.

  1. Antiwhirl PDC bits increased penetration rates in Alberta drilling. [Polycrystalline Diamond Compact

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bobrosky, D.; Osmak, G.

    1993-07-05

    The antiwhirl PDC bits and an inhibitive mud system contributed to the quicker drilling of the time-sensitive shales. The hole washouts in the intermediate section were dramatically reduced, resulting in better intermediate casing cement jobs. Also, the use of antirotation PDC-drillable cementing plugs eliminated the need to drill out plugs and float equipment with a steel tooth bit and then trip for the PDC bit. By using an antiwhirl PDC bit, at least one trip was eliminated in the intermediate section. Offset data indicated that two to six conventional bits would have been required to drill the intermediate hole interval.more » The PDC bit was rebuildable and therefore rerunnable even after being used on five wells. In each instance, the cost of replacing chipped cutters was less than the cost of a new insert roller cone bit. The paper describes the antiwhirl bits; the development of the bits; and their application in a clastic sequence, a carbonate sequence, and the Shekilie oil field; the improvement in the rate of penetration; the selection of bottom hole assemblies; washout problems; and drill-out characteristics.« less

  2. Treatment response of airway clearance assessed by single-breath washout in children with cystic fibrosis.

    PubMed

    Abbas, Chiara; Singer, Florian; Yammine, Sophie; Casaulta, Carmen; Latzin, Philipp

    2013-12-01

    We studied the ability of 4 single-breath gas washout (SBW) tests to measure immediate effects of airway clearance in children with CF. 25 children aged 4-16 years with CF performed pulmonary function tests to assess short-term variability at baseline and response to routine airway clearance. Tidal helium and sulfur hexafluoride (double-tracer gas: DTG) SBW, tidal capnography, tidal and vital capacity nitrogen (N2) SBW and spirometry were applied. We analyzed the gasses' phase III slope (SnIII--normalized for tidal volume) and FEV1 from spirometry. SnIII from tidal DTG-SBW, SnIII from vital capacity N2-SBW, and FEV1 improved significantly after airway clearance. From these tests, individual change of SnIII from tidal DTG-SBW and FEV1 exceeded short-term variability in 10 and 6 children. With the tidal DTG-SBW, an easy and promising test for peripheral gas mixing efficiency, immediate pulmonary function response to airway clearance can be assessed in CF children. Copyright © 2013 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

  3. A new primaquine analogue, tafenoquine (WR 238605), for prophylaxis against Plasmodium falciparum malaria.

    PubMed

    Shanks, G D; Oloo, A J; Aleman, G M; Ohrt, C; Klotz, F W; Braitman, D; Horton, J; Brueckner, R

    2001-12-15

    We tested tafenoquine (WR 238605), a new long-acting 8-aminoquinoline, for its ability to prevent malaria in an area that is holoendemic for Plasmodium falciparum. In a double-blinded, placebo-controlled, randomized clinical trial in western Kenya, adult volunteers received a treatment course of 250 mg halofantrine per day for 3 days, to effect clearance of preexisting parasites. The volunteers were then assigned to 1 of 4 drug regimens: placebo throughout; 3 days of 400 mg (base) of tafenoquine per day, followed by placebo weekly; 3 days of 200 mg of tafenoquine per day, followed by 200 mg per week; and 3 days of 400 mg of tafenoquine per day, followed by 400 mg per week. Prophylaxis was continued for up to 13 weeks. Of the evaluable subjects (223 of 249 randomized subjects), volunteers who received 400 mg tafenoquine for only 3 days had a protective efficacy of 68% (95% confidence interval [CI], 53%-79%), as compared with placebo recipients; those who received 200 mg per day for 3 days followed by 200 mg per week had a protective efficacy of 86% (95% CI, 73%-93%); and those who received 400 mg for 3 days followed by 400 mg per week had a protective efficacy of 89% (95% CI, 77%-95%). A similar number of volunteers in the 4 treatment groups reported adverse events. Prophylactic regimens of 200 mg or 400 mg of tafenoquine, taken weekly for < or =13 weeks, are highly efficacious in preventing falciparum malaria and are well tolerated.

  4. [Comparison of initial and delayed myocardial imaging with beta-methyl-p-[123I]-iodophenylpentadecanoic acid in acute myocardial infarction].

    PubMed

    Naruse, H; Yoshimura, N; Yamamoto, J; Morita, M; Fukutake, N; Ohyanagi, M; Iwasaki, T; Fukuchi, M

    1994-01-01

    Myocardial imaging using beta-methyl-p-[123I]-iodophenylpentadecanoic acid (BMIPP) of 15 patients with acute myocardial infarction was performed to assess "fill-in" and "washout" defects in the delayed myocardial image. The initial and delayed images were evaluated by a visual and quantitative washout rate method. Visual judgement found 8/180 (4%) segments showed "fill-in" defects, and 24/180 segments (13%) showed "washout" defects. There was no relationship between days from onset to the study and the frequency of fill-in and washout defects. The mean washout rate in the segments with "fill-in" defects was 9.0 +/- 16.6%, and that of "washout" defects was 24.9 +/- 18.1% which was significantly higher than in controls (8.7 +/- 15.4%, p < 0.05). There was no correlation between mean washout rate and total blood lipids, total cholesterol, triglyceride and HDL-cholesterol. Therefore, neither time from onset nor blood lipids level was related to changes from the initial image to the delayed image. These changes may be due to relative (false) findings due to changes in circumference, and may be based on myocardial characteristics after myocardial infarction and/or reperfusion.

  5. Formation of methemoglobin and metmyoglobin using 8-aminoquinoline derivatives or sodium nitrite and subsequent reaction with cyanide.

    PubMed

    Steinhaus, R K; Baskin, S I; Clark, J H; Kirby, S D

    1990-10-01

    The kinetics of the oxidation of hemoglobin (Hb) and myoglobin (Mb) by sodium nitrite, 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-quinoline diphosphate (primaquine), 6-methoxy-8-(6-diethylaminohexylamino)-4-methyl-quinoline dihydrochloride (WR6026) and 8-[(4-amino-1-methylbutyl)amino]-2,6-dimethoxy-4-methyl- 5-[(3-trifluoromethyl)phenoxy]quinoline succinate (WR238,605) were studied at pH values ranging from 7.4 to 7.6 and at 37 +/- 1 degrees C. The reaction between Hb and primaquine, WR6026 and WR238,605 resulted in precipitation, as did the reaction between Mb and WR238,605. The reaction between nitrite ion (NO2-) and Hb showed a lag period followed by an autocatalytic phase. The data in this study are consistent with and substantiate the proposed mechanism for the Hb-NO2- oxidation reaction. The reaction between Mb and NO2- at higher NO2- concentrations also showed a lag period followed by an autocatalytic period, while at lower NO2- concentrations no lag period was seen. The data suggest a shift in rate constant at these lower NO2- concentrations. The reaction between Mb and both WR6026 and primaquine followed a two-term rate law with oxidant-dependent and -independent terms. Concentration-effect curve data, along with these results, suggest the presence of a catalytic pathway. The rates of formation of cyanomethemoglobin and cyanometmyoglobin complexes from cyanide ion and methemoglobin (MHb) and metmyoglobin (MMb), respectively, were followed in the presence of the heme oxidants. The rate constants were all within a narrow range and suggest that complexation of cyanide by MHb and MMb is not affected by the presence of oxidants.

  6. Evaluation of spatial plan in controlling stream flow rate in Wakung Watershed, Pemalang, Central Java, Indonesia

    NASA Astrophysics Data System (ADS)

    Anwar, Y.; Setyasih, I.; Setiawan, M. A.; Christanto, N.

    2018-04-01

    Evaluation study for such a regional spatial plan (RTRW) in Indonesia has not been evaluated for its effectiveness in controlling the surface run off that contributed to streamflow. This necessity can be accomplishsed by applying a modeling approach, such as Soil Water Assessment Tool (SWAT). The objectives of this research are 1) to simulate the streamflow of Wakung watershed based on actual landuse, 2) to predict streamflow of Wakung watershed based on RTRW, and 3) to evaluate the effectiveness of the RTRW of Pemalang District in controling streamflow rate at Wakung Watershed. ArcSWAT model was used to determine the erosion rate prediction. The model was then calibrated by using SWATCUP. Model performance were tested by using R2 and ENS. The calibration and validation results showed that R2 and ENS (monthly) > 0.5. The result of SWAT simulation in Wakung sub-watershed reaching 161 - 4950 m3/s/years for W-A scenario (actual landuse and weather data of 2013), for scenario W-R (RTRW and weather data of 2013), 330 - 4919 m3/s/year. The comparison between actual and spatial plan land use data for stream flow is showing that the W-A scenario is lower than the W-R scenario in 19 sub watersheds. This is because there are many plans for adding land use for urban and intensive horticulture land in areas with steep slopes (> 25%). This condition is caused by the demands of fulfilling the needs of settlement and food for people in the Wakung watershed.

  7. An Extreme Case of a Misaligned Highly Flattened Wind in the Wolf-Rayet Binary CX Cephei

    NASA Astrophysics Data System (ADS)

    Villar-Sbaffi, A.; St-Louis, N.; Moffat, Anthony F. J.; Piirola, Vilppu

    2006-04-01

    CX Cep (WR 151) is the WR+O binary (WN5+O5 V) with the second shortest period known in our Galaxy. To examine the circumstellar matter distribution and to better constraint the orbital parameters and mass-loss rate of the W-R star, we obtained broadband and multiband (i.e., UBVRI) linear polarization observations of the system. Our analysis of the phase-locked polarimetric modulation confirms the high orbital inclination of the system (i.e., i=65deg). Using the orbital solution of Lewis et al. (1993), we obtain masses of 33.9 and 23.9 Msolar for the O and W-R stars, respectively, which agree with their spectral types. A simple polarimetric model accounting for finite stellar size effects allowed us to derive a mass-loss rate for the W-R star of (0.3-0.5)×10-5 Msolar yr-1. This result was remarkably independent of the model's input parameters and favors an earlier spectral type for the W-R component (i.e., WN4). Finally, using our multiband observations, we fitted and subtracted from our data the interstellar polarization. The resulting constant intrinsic polarization of 3%-4% is misaligned in relation to the orbital plane (i.e., θCIP=26deg vs. Ω=75deg) and is the highest intrinsic polarization ever observed for a W-R star. This misalignment points toward a rotational (or magnetic) origin for the asymmetry and contradicts the most recent evolutionary models for massive stars (Meynet & Maeder 2003) that predict spherically symmetric winds during the W-R phase (i.e., CIP=0%).

  8. Optical spectroscopy of the bladder washout fluid to optimize fluorescence cystoscopy with Hexvix®.

    PubMed

    Martoccia, Carla; Zellweger, Matthieu; Lovisa, Blaise; Jichlinski, Patrice; van den Bergh, Hubert; Wagnières, Georges

    2014-09-01

    Fluorescence cystoscopy enhances detection of early bladder cancer. Water used to inflate thebladder during the procedure rapidly contains urine, which may contain fluorochromes. This frequently degradesfluorescence images. Samples of bladder washout fluid (BWF) or urine were collected (15 subjects). We studiedtheir fluorescence properties and assessed changes induced by pH (4 to 9) and temperature (15°C to 41°C).A typical fluorescence spectrum of BWF features a main peak (excitation/emission: 320∕420 nm, FWHM =50∕100 nm) and a weaker (5% to 20% of main peak intensity), secondary peak (excitation/emission: 455∕525 nm, FWHM = 80∕50 nm). Interpatient fluctuations of fluorescence intensity are observed. Fluorescence intensity decreases when temperature increases (max 30%) or pH values vary (max 25%). Neither approach is compatible with clinical settings. Fluorescence lifetime measurements suggest that 4-pyridoxic acid/riboflavin is the most likely molecule responsible for urine’s main/secondary fluorescence peak. Our measurements give an insight into the spectroscopy of the detrimental background fluorescence. This should be included in the optical design of fluorescence cystoscopes. We estimate that restricting the excitation range from 370–430 nm to 395–415 nm would reduce the BWF background by a factor 2.

  9. How Wolf-Rayet winds are driven by starlight and spectral lines

    NASA Astrophysics Data System (ADS)

    Onifer, Andrew Joseph, III

    Finding the cause of the enormous increase in the mass- loss rate of a Wolf-Rayet (W-R) star, as compared to its O star progenitor, has remained a challenge for many years. This thesis explores the hypothesis that line driving causes the large observed W-R mass-loss rates. Frequency redistribution can cause the photons to filter into gaps in the line spectrum, reducing the efficiency of line driving. Therefore, the role that frequency redistribution plays in lowering the predicted mass-loss rate is explored, both via simple two-domain idealizations of the line list and via a real W-R line list. A simple analytic theory, called the Statistical Sobolev Rosseland (SSR) theory, is developed that calculates the local efficiency of line driving in a completely redistributing wind. In the process a conceptual language is developed to explain the key issues in W-R wind line driving. The results are that with no redistribution, the reduction in radius, and corresponding increase in temperature, of an O star as it evolves into a W-R star causes roughly a six-fold increase in the mass-loss rate. However, with large amounts of redistribution, the efficiency of the wind drops greatly in the presence of spectral gaps. In the most extreme case of SSR, the mass- loss rate drops by a factor of up to an order of magnitude relative to the gray value. To avoid this it is necessary to fill the gaps in the spectrum, and the effect that ionization stratification has in filling the gaps globally over the wind is explored. It is found that with the current line list ionization changes can only fill the gaps sufficiently to cause about a factor of two increase over the SSR value. The conclusion is that in order for line driving to explain the mass-loss rates of W-R winds, more opacity needs to be discovered to fill the gaps, either locally, or globally over a realistic range of ionization strata.

  10. Radioprotection of intestinal stem cells and whole body radiation lethality from photons and neutrons by prostaglandins along or in combination with WR-2721. Technical report 24 Feb 86-30 Sep 89

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hanson, W.R.

    1990-12-01

    Prostaglandins (PGs) have been shown to protect the gastrointestinal and hematopoietic cell renewal systems from some degree of radiation damage. The mechanism(s) to account for these observations are unknown. Based on preliminary evidence that PGs varied in the degree to which they afforded protection of intestinal stem cells, we studied protection by several PGs and their analogues. The most protective PGs found to date were 16,16 dm PGE2, misoprostol, a PGE1 analogues, and iloprost, a PGI2 analogue. The relative degrees of protection were 400%, 700% and 800% above control values at a dose of 13.5 137 Cs gamma radiation. Thesemore » three PGs were used for subsequent studies. Iloprost is a stable PG at room temperature and was found to be protective given orally. In addition to radioprotection of the intestinal stem cells, these Pgs increased the LD50/6, LD50/30 and animal longevity through both the gastrointestinal and hematopoietic syndromes. Misoprostol protected the gut from JANUS neutrons and increased animal longevity following neutron irradiation. Although the mechanism for PG-induced radioprotection is unknown, it appears to be different compared to the widely studied amino thiol, WR-2721. Evidence to support this contention came from data showing that all these analogues were additive to the protective effect of Wr-2721.« less

  11. The clinical utility of lung clearance index in early cystic fibrosis lung disease is not impacted by the number of multiple-breath washout trials

    PubMed Central

    Foong, Rachel E.; Harper, Alana J.; King, Louise; Turkovic, Lidija; Davis, Miriam; Clem, Charles C.; Davis, Stephanie D.; Ranganathan, Sarath; Hall, Graham L.

    2018-01-01

    The lung clearance index (LCI) from the multiple-breath washout (MBW) test is a promising surveillance tool for pre-school children with cystic fibrosis (CF). Current guidelines for MBW testing recommend that three acceptable trials are required. However, success rates to achieve these criteria are low in children aged <7 years and feasibility may improve with modified pre-school criteria that accepts tests with two acceptable trials. This study aimed to determine if relationships between LCI and clinical outcomes of CF lung disease differ when only two acceptable MBW trials are assessed. Healthy children and children with CF aged 3–6 years were recruited for MBW testing. Children with CF also underwent bronchoalveolar lavage fluid collection and a chest computed tomography scan. MBW feasibility increased from 46% to 75% when tests with two trials were deemed acceptable compared with tests where three acceptable trials were required. Relationships between MBW outcomes and markers of pulmonary inflammation, infection and structural lung disease were not different between tests with three acceptable trials compared with tests with two acceptable trials. This study indicates that pre-school MBW data from two acceptable trials may provide sufficient information on ventilation distribution if three acceptable trials are not possible. PMID:29707562

  12. Spatial distribution of Galactic Wolf-Rayet stars and implications for the global population

    NASA Astrophysics Data System (ADS)

    Rosslowe, C. K.; Crowther, P. A.

    2015-03-01

    We construct revised near-infrared absolute magnitude calibrations for 126 Galactic Wolf-Rayet (WR) stars at known distances, based in part upon recent large-scale spectroscopic surveys. Application to 246 WR stars located in the field permits us to map their Galactic distribution. As anticipated, WR stars generally lie in the thin disc (˜40 pc half-width at half-maximum) between Galactocentric radii 3.5-10 kpc, in accordance with other star formation tracers. We highlight 12 WR stars located at vertical distances of ≥300 pc from the mid-plane. Analysis of the radial variation in WR subtypes exposes a ubiquitously higher NWC/NWN ratio than predicted by stellar evolutionary models accounting for stellar rotation. Models for non-rotating stars or accounting for close binary evolution are more consistent with observations. We consolidate information acquired about the known WR content of the Milky Way to build a simple model of the complete population. We derive observable quantities over a range of wavelengths, allowing us to estimate a total number of 1900 ± 250 Galactic WR stars, implying an average duration of ˜ 0.4 Myr for the WR phase at the current Milky Way star formation rate. Of relevance to future spectroscopic surveys, we use this model WR population to predict follow-up spectroscopy to KS ≃ 17.5 mag will be necessary to identify 95 per cent of Galactic WR stars. We anticipate that ESA's Gaia mission will make few additional WR star discoveries via low-resolution spectroscopy, though will significantly refine existing distance determinations. Appendix A provides a complete inventory of 322 Galactic WR stars discovered since the VIIth catalogue (313 including Annex), including a revised nomenclature scheme.

  13. Success in Developing Regions: World Records Evolution through a Geopolitical Prism

    PubMed Central

    Guillaume, Marion; Helou, Nour El; Nassif, Hala; Berthelot, Geoffroy; Len, Stéphane; Thibault, Valérie; Tafflet, Muriel; Quinquis, Laurent; Desgorces, François; Hermine, Olivier; Toussaint, Jean-François

    2009-01-01

    A previous analysis of World Records (WR) has revealed the potential limits of human physiology through athletes' personal commitment. The impact of political factors on sports has only been studied through Olympic medals and results. Here we studied 2876 WR from 63 nations in four summer disciplines. We propose three new indicators and show the impact of historical, geographical and economical factors on the regional WR evolution. The south-eastward path of weighted annual barycenter (i.e. the average of country coordinates weighting by the WR number) shows the emergence of East Africa and China in WR archives. Home WR ratio decreased from 79.9% before the second World War to 23.3% in 2008, underlining sports globalization. Annual Cumulative Proportions (ACP, i.e. the cumulative sum of the WR annual rate) highlight the regional rates of progression. For all regions, the mean slope of ACP during the Olympic era is 0.0101, with a maximum between 1950 and 1989 (0.0156). For European countries, this indicator reflects major historical events (slowdown for western countries after 1945, slowdown for eastern countries after 1990). Mean North-American ACP slope is 0.0029 over the century with an acceleration between 1950 and 1989 at 0.0046. Russia takes off in 1935 and slows down in 1988 (0.0038). For Eastern Europe, maximal progression is seen between 1970 and 1989 (0.0045). China starts in 1979 with a maximum between 1990 and 2008 (0.0021), while other regions have largely declined (mean ACP slope for all other countries  = 0.0011). A similar trend is observed for the evolution of the 10 best performers. The national analysis of WR reveals a precise and quantifiable link between the sport performances of a country, its historical or geopolitical context, and its steps of development. PMID:19862324

  14. Do the Threshold Limit Values for Work in Hot Conditions Adequately Protect Workers?

    PubMed

    Meade, Robert D; Poirier, Martin P; Flouris, Andreas D; Hardcastle, Stephen G; Kenny, Glen P

    2016-06-01

    We evaluated core temperature responses and the change in body heat content (ΔHb) during work performed according to the ACGIH threshold limit values (TLV) for heat stress, which are designed to ensure a stable core temperature that does not exceed 38.0°C. Nine young males performed a 120-min work protocol consisting of cycling at a fixed rate of heat production (360 W). On the basis of the TLV, each protocol consisted of a different work-rest (WR) allocation performed in different wet-bulb globe temperatures (WBGT). The first was 120 min of continuous (CON) cycling at 28.0°C WBGT (CON[28.0°C]). The remaining three protocols were intermittent work bouts (15-min duration) performed at various WR and WBGT: (i) WR of 3:1 at 29.0°C (WR3:1[29.0°C]), (ii) WR of 1:1 at 30.0°C (WR1:1[30.0°C]), and (iii) WR of 1:3 at 31.5°C (WR1:3[31.5°C]) (total exercise time: 90, 60, and 30 min, respectively). The change in rectal (ΔTre) and mean body temperature (ΔTb) was evaluated with thermometry. ΔHb was determined via direct calorimetry and also used to calculate ΔTb. Although average rectal temperature did not exceed 38.0°C, heat balance was not achieved during exercise in any work protocol (i.e., rate of ΔTre > 0°C·min; all P values ≤ 0.02). Consequently, it was projected that if work was extended to 4 h, the distribution of participant core temperatures higher and lower than 38.0°C would be statistically similar (all P values ≥ 0.10). Furthermore, ΔHb was similar between protocols (P = 0.70). However, a greater ΔTb was observed with calorimetry relative to thermometry in WR3:1[29.0°C] (P = 0.03), WR1:1[30.0°C] (P = 0.02), and WR1:3[31.5°C] (P < 0.01) but not CON[28.0°C] (P = 0.32). The current study demonstrated that heat balance was not achieved and ΔTb and ΔHb were inconsistent, suggesting that the TLV may not adequately protect workers during work in hot conditions.

  15. Application of the Speed-Duration Relationship to Normalize the Intensity of High-Intensity Interval Training

    PubMed Central

    Ferguson, Carrie; Wilson, John; Birch, Karen M.; Kemi, Ole J.

    2013-01-01

    The tolerable duration of continuous high-intensity exercise is determined by the hyperbolic Speed-tolerable duration (S-tLIM) relationship. However, application of the S-tLIM relationship to normalize the intensity of High-Intensity Interval Training (HIIT) has yet to be considered, with this the aim of present study. Subjects completed a ramp-incremental test, and series of 4 constant-speed tests to determine the S-tLIM relationship. A sub-group of subjects (n = 8) then repeated 4 min bouts of exercise at the speeds predicted to induce intolerance at 4 min (WR4), 6 min (WR6) and 8 min (WR8), interspersed with bouts of 4 min recovery, to the point of exercise intolerance (fixed WR HIIT) on different days, with the aim of establishing the work rate that could be sustained for 960 s (i.e. 4×4 min). A sub-group of subjects (n = 6) also completed 4 bouts of exercise interspersed with 4 min recovery, with each bout continued to the point of exercise intolerance (maximal HIIT) to determine the appropriate protocol for maximizing the amount of high-intensity work that can be completed during 4×4 min HIIT. For fixed WR HIIT tLIM of HIIT sessions was 399±81 s for WR4, 892±181 s for WR6 and 1517±346 s for WR8, with total exercise durations all significantly different from each other (P<0.050). For maximal HIIT, there was no difference in tLIM of each of the 4 bouts (Bout 1: 229±27 s; Bout 2: 262±37 s; Bout 3: 235±49 s; Bout 4: 235±53 s; P>0.050). However, there was significantly less high-intensity work completed during bouts 2 (153.5±40. 9 m), 3 (136.9±38.9 m), and 4 (136.7±39.3 m), compared with bout 1 (264.9±58.7 m; P>0.050). These data establish that WR6 provides the appropriate work rate to normalize the intensity of HIIT between subjects. Maximal HIIT provides a protocol which allows the relative contribution of the work rate profile to physiological adaptations to be considered during alternative intensity-matched HIIT protocols. PMID:24244266

  16. The recommended Threshold Limit Values for heat exposure fail to maintain body core temperature within safe limits in older working adults.

    PubMed

    Lamarche, Dallon T; Meade, Robert D; D'Souza, Andrew W; Flouris, Andreas D; Hardcastle, Stephen G; Sigal, Ronald J; Boulay, Pierre; Kenny, Glen P

    2017-09-01

    The American Conference of Governmental and Industrial Hygienists (ACGIH®) Threshold Limit Values (TLV® guidelines) for work in the heat consist of work-rest (WR) allocations designed to ensure a stable core temperature that does not exceed 38°C. However, the TLV® guidelines have not been validated in older workers. This is an important shortcoming given that adults as young as 40 years demonstrate impairments in their ability to dissipate heat. We therefore evaluated body temperature responses in older adults during work performed in accordance to the TLV® recommended guidelines. On three occasions, 9 healthy older (58 ± 5 years) males performed a 120-min work-simulated protocol in accordance with the TLV® guidelines for moderate-to-heavy intensity work (360 W fixed rate of heat production) in different wet-bulb globe temperatures (WBGT). The first was 120 min of continuous (CON) cycling at 28.0°C WBGT (CON[28°C]). The other two protocols were 15-min intermittent work bouts performed with different WR cycles and WBGT: (i) WR of 3:1 at 29.0°C (WR3:1[29°C]) and (ii) WR of 1:1 at 30.0°C (WR1:1[30°C]). Rectal temperature was measured continuously. The rate of change in mean body temperature was determined via thermometry (weighting coefficients: rectal, 0.9; mean skin temperature, 0.1) and direct calorimetry. Rectal temperature exceeded 38°C in all participants in CON[28°C] and WR3:1[29°C] whereas a statistically similar proportion of workers exceeded 38°C in WR1:1[30°C] (χ 2 ; P = 0.32). The average time for rectal temperature to reach 38°C was: CON[28°C], 53 ± 7; WR3:1[29°C], 79 ± 11; and WR1:1[30°C], 100 ± 29 min. Finally, while a stable mean body temperature was not achieved in any work condition as measured by thermometry (i.e., >0°C·min -1 ; all P<0.01), heat balance as determined by direct calorimetry was achieved in WR3:1[29°C] and WR1:1[30°C] (both P ≥ 0.08). Our findings indicate that the TLV® guidelines do not prevent

  17. Washout of heme-containing proteins dramatically improves tetrazolium-based infarct staining.

    PubMed

    Pitts, Kelly R; Stiko, Ann; Buetow, Bernard; Lott, Fred; Guo, Ping; Virca, Duke; Toombs, Christopher F

    2007-01-01

    Methods to determine infarct size following ischemia-reperfusion injury include gross staining with triphenyltetrazolium chloride (TTC) and perfusion of colored dyes to demarcate the non-ischemic zone. Infarcted tissue (INF) can typically appear a mottled tan to brownish color, making a border between INF and TTC-positive tissue difficult to discern. Previous work in our lab indicated that following TTC staining, prolonged washing of thick sections dramatically sharpened this boundary. Adult rats underwent 30 min ischemia via LAD ligation and reperfusion/recovery over 24 h. Hearts were then harvested, thick-sectioned, and stained with TTC. Stained sections were stored in PBS at 4 degrees C for up to 3 weeks. Histology on thin sections from infarcted hearts fixed directly after harvest revealed extensive hemorrhage within the INF. However, this hemorrhage is washed out when hearts are stored in PBS for 3 weeks. SDS-PAGE of PBS samples taken at 1, 2, and 3 weeks showed a low molecular weight band appearing over time. Peptide sequencing revealed the presence of several proteins including the heme-containing proteins (HCPs) hemoglobin, cytochrome c, and myoglobin. The loss of HCPs from thick sections to PBS corresponded with the blanching of the previously mottled INF within each section. HPLC analysis of these samples confirmed the loss of HCPs contributes to INF whitening. Further, analysis of infarct size values derived from heart slices with or without HCPs showed a significant decrease in measurement error when values were derived from slices without HCPs. These data suggest that HCPs in the heart tissue contribute to the non-uniform and discolored appearance of the INF, and that washout of these proteins produces an INF more easily distinguished from neighboring non-infarcted tissue. This method greatly reduces the error associated with infarct measurements and improves the analysis of the effects of drug treatments and other interventions designed to impact

  18. Sulfur Dioxide Emission Rates from Kilauea Volcano, Hawai`i, an Update: 1998-2001

    USGS Publications Warehouse

    Elias, Tamar; Sutton, A. Jefferson

    2002-01-01

    Introduction Sulfur dioxide (SO2) emission rates from Kilauea Volcano were first measured by Stoiber and Malone (1975) and have been measured on a regular basis since 1979 (Greenland and others, 1985; Casadevall and others, 1987; Elias and others, 1998; Sutton and others, 2001). A compilation of SO2 emission-rate and wind-vector data from 1979 through 1997 is available as Open-File Report 98-462 (Elias and others, 1998) and on the web at http://hvo.wr.usgs.gov/products/OF98462/. The purpose of this report is to update the existing database through 2001. Kilauea releases SO2 gas predominantly from its summit caldera and east rift zone (ERZ) (fig. 1), as described in previous reports (Elias and others, 1998; Sutton and others, 2001). These two distinct sources are quantified independently. The summit and east rift zone emission rates reported here were derived using vehicle-based Correlation Spectrometry (COSPEC) measurements as described in Elias and others (1998). In 1998 and 1999, these measurements were augmented with airborne and tripod-based surveys.

  19. Effects of added antibiotics on the basic properties of anti-washout-type fast-setting calcium phosphate cement.

    PubMed

    Takechi, M; Miyamoto, Y; Ishikawa, K; Nagayama, M; Kon, M; Asaoka, K; Suzuki, K

    1998-02-01

    The effect of added antibiotics on the basic properties of anti-washout-type fast-setting calcium phosphate cement (aw-FSCPC) was investigated in a preliminary evaluation of aw-FSCPC containing drugs. Flomoxef sodium was employed as the antibiotic and was incorporated into the powder-phase aw-FSCPC at up to 10%. The setting time, consistency, wet diametral tensile strength (DTS) value, and porosity were measured for aw-FSCPC containing various amounts of flomoxef sodium. X-ray diffraction (XRD) analysis was also conducted for the identification of products. To evaluate the drug-release profile, set aw-FSCPC was immersed in saline and the released flomoxef sodium was determined at regular intervals. The spread area of the cement paste as an index of consistency of the cement increased progressively with the addition of flomoxef sodium, and it doubled when the aw-FSCPC contained 8% flomoxef sodium. In contrast, the wet DTS value decreased with increase in flomoxef sodium content. Bulk density measurement and scanning electron microscopic observation revealed that the set mass was more porous with the amount of flomoxef sodium contained in the aw-FSCPC. The XRD analysis revealed that formation of hydroxyapatite (HAP) from aw-FSCPC was reduced even after 24 h, when the aw-FSCPC contained flomoxef sodium at > or = 6%. Therefore, the decrease of wet DTS value was thought to be partly the result of the increased porosity and inhibition of HAP formation in aw-FSCPC containing large amounts of flomoxef sodium. The flomoxef sodium release from aw-FSCPC showed the typical profile observed in a skeleton-type drug delivery system (DDS). The rate of drug release from aw-FSCPC can be controlled by changing the concentration of sodium alginate. Although flomoxef sodium addition has certain disadvantageous effects on the basic properties of aw-FSCPC, we conclude that aw-FSCPC is a good candidate for potential use as a DDS carrier that may be useful in surgical operations.

  20. The Citius End: World Records Progression Announces the Completion of a Brief Ultra-Physiological Quest

    PubMed Central

    Berthelot, Geoffroy; Thibault, Valérie; Tafflet, Muriel; Escolano, Sylvie; El Helou, Nour; Jouven, Xavier; Hermine, Olivier; Toussaint, Jean-François

    2008-01-01

    World records (WR) in sports illustrate the ultimate expression of human integrated muscle biology, through speed or strength performances. Analysis and prediction of man's physiological boundaries in sports and impact of external (historical or environmental) conditions on WR occurrence are subject to scientific controversy. Based on the analysis of 3263 WR established for all quantifiable official contests since the first Olympic Games, we show here that WR progression rate follows a piecewise exponential decaying pattern with very high accuracy (mean adjusted r2 values = 0.91±0.08 (s.d.)). Starting at 75% of their estimated asymptotic values in 1896, WR have now reached 99%, and, present conditions prevailing, half of all WR will not be improved by more than 0,05% in 2027. Our model, which may be used to compare future athletic performances or assess the impact of international antidoping policies, forecasts that human species' physiological frontiers will be reached in one generation. This will have an impact on the future conditions of athlete training and on the organization of competitions. It may also alter the Olympic motto and spirit. PMID:18253499

  1. Subcutaneous blood flow in psoriasis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Klemp, P.

    1985-03-01

    The simultaneously recorded disappearance rates of /sup 133/xe from subcutaneous adipose tissue in the crus were studied in 10 patients with psoriasis vulgaris using atraumatic labeling of the tissue in lesional skin (LS) areas and symmetrical, nonlesional skin (NLS) areas. Control experiments were performed bilaterally in 10 younger, healthy subjects. The subcutaneous washout rate constant was significantly higher in LS, 0.79 +/- 0.05 min-1 x 10(2) compared to the washout rate constant of NLS, 0.56 +/- 0.07 min-1. 10(2), or the washout rate constant in the normal subjects, 0.46 +/- 0.17 min-1 x 10(2). The mean washout rate constant inmore » NLS was 25% higher than the mean washout rate constant in the normal subjects. The difference was, however, not statistically significant. Differences in the washout rate constants might be due to abnormal subcutaneous tissue-to-blood partition (lambda) in the LS--and therefore not reflecting the real differences in the subcutaneous blood flow (SBF). The lambda for /sup 133/Xe was therefore measured--using a double isotope washout method (/sup 133/Xe and (/sup 131/I)antipyrine)--in symmetrical sites of the lateral crus in LS and NLS of 10 patients with psoriasis vulgaris and in 10 legs of normal subjects. In LS the lambda was 4.52 +/- 1.67 ml/g, which was not statistically different from that of NLS, 5.25 +/- 2.19 ml/g, nor from that of normal subcutaneous tissue, 4.98 +/- 1.04 ml/g. Calculations of the SBF using the obtained lambda values gave a significantly higher SBF in LS, 3.57 +/- 0.23 ml/100 g/min, compared to SBF in the NLS, 2.94 +/- 0.37 ml/100 g/min. There was no statistically significant difference between SBF in NLS and SBF in the normal subjects. The increased SBF in LS of psoriatics might be a secondary phenomenon to an increased heat loss in the lesional skin.« less

  2. The Influence of Exercise Intensity on Postexercise Baroreflex Sensitivity

    ERIC Educational Resources Information Center

    Reynolds, Linda J.; De Ste Croix, Mark B. A.; James, David V. B.

    2017-01-01

    Purpose: The purpose of this study was to investigate the influence of exercise intensity on postexercise supine and tilt baroreflex sensitivity (BRS). Method: Nine healthy, active men performed 2 conditions of interval cycling of 40% maximal work rate (WR[subscript max]) and 75% WR[subscript max] of matched work done and a control condition of no…

  3. Assessment of antiradiation drug effectiveness to fission neutron irradiation. Annual report September 1981-August 1982

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sigdestad, C.P.

    1982-09-01

    This report describes the assays of various compounds for their toxicity and anti-radiation efficacy following exposure to either Co-60 or fission neutron irradiation. The chemicals covered in this report are: WR 347, WR 1065, WR 2529, WR 2721, WR 3689, WR 44923, WR 109342, WR 151327 and WR 168643. The drugs and their respective dose modification factors (DMF) for fission neutron gastrointestinal lethality (LD50-6) following intraperitoneal administration are, in decreasing order of effectiveness: WR 44923 (1.77), WR 2529 (1.47), WR 1065 (1.42), WR 2721 (1.39), WR 16843 (1.23). Following per os (P. O.) administration of the drug, the DMF's formore » the LD50-6 are: WR 109342 (1.47), WR 3689 (1.36), and WR 168643 (1.31). For hematopoietic neutron radiation lethality (LD50-30) the DMF's are: following i.p. administration, WR 2529 (1.04); WR 151327 (1.34), WR 168643 (1.25), WR 44923 (1.22), WR 2721 (1.20), WR 1065 (1.04); following P. O. administration, WR 168643 (1.38), WR 109342 (1.21), WR 3689 (1.04). Using an intestinal microcolony assay system the following drugs provided the listed DMF's against neutron radiation after i.p. injection: WR 3689 (1.24), WR 2721 (1.15), WR 44923 (1.14), and WR 347 (1.05). The protective effects against neutron radiation using an endogenous spleen colony assay and i.p. administration were: WR 3689 (1.18), WR 2529 (1.15), WR 2721 (1.10), WR 44923 (1.02) and WR 347 (0.94).« less

  4. Discovery of a new Wolf-Rayet star and its ring nebula in Cygnus

    NASA Astrophysics Data System (ADS)

    Gvaramadze, V. V.; Fabrika, S.; Hamann, W.-R.; Sholukhova, O.; Valeev, A. F.; Goranskij, V. P.; Cherepashchuk, A. M.; Bomans, D. J.; Oskinova, L. M.

    2009-11-01

    We report the serendipitous discovery of a ring nebula around a candidate Wolf-Rayet (WR) star, HBHA4202-22, in Cygnus using the Spitzer Space Telescope archival data. Our spectroscopic follow-up observations confirmed the WR nature of this star (we named it WR138a) and showed that it belongs to the WN8-9h subtype. We thereby add a new example to the known sample of late WN stars with circumstellar nebulae. We analysed the spectrum of WR138a by using the Potsdam Wolf-Rayet (PoWR) model atmospheres, obtaining a stellar temperature of 40kK. The stellar wind composition is dominated by helium with 20 per cent of hydrogen. The stellar spectrum is highly reddened and absorbed (EB- V = 2.4mag, AV = 7.4mag). Adopting a stellar luminosity of logL/Lsolar = 5.3, the star has a mass-loss rate of 10-4.7Msolaryr-1, and resides in a distance of 4.2 kpc. We measured the proper motion for WR138a and found that it is a runaway star with a peculiar velocity of ~=50kms-1. Implications of the runaway nature of WR138a for constraining the mass of its progenitor star and understanding the origin of its ring nebula are discussed.

  5. Wolf-Rayet phenomena

    NASA Technical Reports Server (NTRS)

    Conti, P. S.

    1982-01-01

    The properties of stars showing Wolf-Rayet phenomena are outlined along with the direction of future work. Emphasis is placed on the characteristics of W-R spectra. Specifically the following topics are covered: the absolute visual magnitudes; the heterogeneity of WN spectra; the existence of transition type spectra and compositions the mass loss rates; and the existence of very luminous and possibly very massive W-R stars. Also, a brief overview of current understanding of the theoretical aspects of stellar evolution and stellar winds and the various scenarios that have been proposed to understand W-R spectra are included.

  6. Comparison of quantitative regional ventilation-weighted fourier decomposition MRI with dynamic fluorinated gas washout MRI and lung function testing in COPD patients.

    PubMed

    Kaireit, Till F; Gutberlet, Marcel; Voskrebenzev, Andreas; Freise, Julia; Welte, Tobias; Hohlfeld, Jens M; Wacker, Frank; Vogel-Claussen, Jens

    2018-06-01

    Ventilation-weighted Fourier decomposition-MRI (FD-MRI) has matured as a reliable technique for quantitative measures of regional lung ventilation in recent years, but has yet not been validated in COPD patients. To compare regional fractional lung ventilation obtained by ventilation-weighted FD-MRI with dynamic fluorinated gas washout MRI ( 19 F-MRI) and lung function test parameters. Prospective study. Twenty-seven patients with chronic obstructive pulmonary disease (COPD, median age 61 [54-67] years) were included. For FD-MRI and for 19 F-MRI a spoiled gradient echo sequence was used at 1.5T. FD-MRI coronal slices were acquired in free breathing. Dynamic 19 F-MRI was performed after inhalation of 25-30 L of a mixture of 79% fluorinated gas (C 3 F 8 ) and 21% oxygen via a closed face mask tubing using a dedicated coil tuned to 59.9 MHz. 19 F washout times in numbers of breaths ( 19 F-n breaths ) as well as fractional ventilation maps for both methods (FD-FV, 19 F-FV) were calculated. Slices were matched using a landmark driven algorithm, and only corresponding slices with an overlap of >90% were coregistered for evaluation. The obtained parameters were correlated with each other using Spearman's correlation coefficient (r). FD-FV strongly correlated with 19 F-n breaths on a global (r = -0.72, P < 0.0001) as well as on a lobar level and with lung function test parameters (FD-FV vs. FEV1, r = 0.76, P < 0.0001). There was a small systematic overestimation of FD-FV compared to 19 F-FV (mean difference -0.03 (95% confidence interval [CI]: -0.097; -0.045). Regional ventilation-weighted Fourier decomposition-MRI is a promising noninvasive, radiation-free tool for quantification of regional ventilation in COPD patients. 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:1534-1541. © 2017 International Society for Magnetic Resonance in Medicine.

  7. Calcitonin assay in wash-out fluid after fine-needle aspiration biopsy in patients with a thyroid nodule and border-line value of the hormone.

    PubMed

    Massaro, F; Dolcino, M; Degrandi, R; Ferone, D; Mussap, M; Minuto, F; Giusti, M

    2009-04-01

    Assaying calcitonin (CT) in the wash-out fluid from fine-needle aspiration biopsies (CT-FNAB) could be useful in the diagnosis of medullary thyroid carcinoma (MTC). The aim of this study was to correlate serum CT with cytology and CT-FNAB. Twenty-seven subjects (age range 27-75 yr) were studied. FNAB was performed in a thyroid nodule (no.=16) or lymph-node (no.=1 previously operated on for MTC) or in the prevalent nodule of multinodular goiters (no.=10). CT-FNAB values obtained in 37 subjects with normal serum CT (<10 ng/l) who underwent FNAB for thyroid nodules served as a negative control. In these subjects, CTFNAB values were 8.2+/-6.4 ng/l (range 2-30 ng/l). In patients with a thyroid nodule under evaluation for MTC, serum CT and CT-FNAB values were 14.5+/-3.9 ng/l (range 10-24 ng/l) and 16.4+/-29.8 ng/l (range 2-144 ng/l), respectively. In 4 patients, CT-FNAB values were higher than the highest values found in our negative controls (30 ng/l), but cytology results were compatible with a benign thyroid lesion and pentagastrin testing was negative. In 3 cases with CT-FNAB <30 ng/l, cytology was indicative of an indeterminate or probably follicular malignant lesion and histology was negative for MTC. None of the other subjects in whom pentagastrin testing was conducted showed serum CT values >100 ng/l. Our data do not show any correlation between CT-FNAB and serum CT. In conclusion, borderline CT values in patients with thyroid nodules are not rare. Our experience suggests that CT-FNAB does not have the same importance as that reported in the literature for thyroglobulin and PTH assay in wash-out fluid after FNAB in malignant thyroid and hyperfunctioning parathyroid lesions.

  8. Complementary role of parathormone washout test to 99mTc-MIBI parathyroid scintigraphy and histopathologic analysis of cell types in parathyroid adenomas.

    PubMed

    Ince, Semra; Emer, Ozdes; Deveci, Salih; Okuyucu, Kursat; Alagoz, Engin; San, Huseyin; Ayan, Aslı; Karacalioglu, Ozgur; Haymana, Cem; Gunalp, Bengul; Arslan, Nuri

    2018-05-02

    Parathyroid scintigraphy (PS) can be negative or equivocal (N/E) in a considerable number of cases with highly suspicious clinical findings and biochemical results for parathyroid adenoma (PA). The aims of this study were to investigate the complementary role of parathormone washout test (PWT) to PS in patients with primary hyperparathyroidism (PHPT) and evaluate histopathologic aspects of PAs in comparison with PS results. Thirty-eight patients with PHPT referred for PS were included in the study. Seventeen patients had both scintigraphic and ultrasonographic findings concordant with PA (Group A). Twenty-one patients having N/E PS, but suspected lesions for PA on ultrasonography (US) formed Group B. PWT was performed for all patients and they underwent the surgical intervention. An adenoma was removed in all patients and the histopathologic cell characteristics were established. The tumor size on US was larger in those patients whose adenomas were seen on the PS (P<.001). The percentages of chief (or principal), oxyphilic and clear cells in PAs were not statistically different between the groups. Serum parathormone level and PWT were not statistically significant between Group A and Group B (P=.095 and P=.04, respectively). Although there is not a definitive threshold value, the sensitivity of PS increases with lesion size. While chief cell and oxyphilic cell content of PAs tend to deplete in N/E PS, clear cell rate increases substantially. Combining PS with both US and PWT increases the sensitivity of detection and localization of PAs. Copyright © 2018. Publicado por Elsevier España, S.L.U.

  9. RED EYES ON WOLF-RAYET STARS: 60 NEW DISCOVERIES VIA INFRARED COLOR SELECTION

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mauerhan, Jon C.; Van Dyk, Schuyler D.; Morris, Patrick W., E-mail: mauerhan@ipac.caltech.edu

    We have spectroscopically identified 60 Galactic Wolf-Rayet (WR) stars, including 38 nitrogen types (WN) and 22 carbon types (WC). Using photometry from the Spitzer/GLIMPSE and Two Micron All Sky Survey databases, the new WRs were selected via a method we have established that exploits their unique infrared colors, which is mainly the result of excess radiation generated by free-free scattering within their dense ionized winds. The selection criterion has been refined since the last report, resulting in a WR detection rate of {approx}20% in spectroscopic follow-up of candidates that comprise a broad color space defined by the color distribution ofmore » all known WRs having B > 14 mag. However, there are smaller regions within this color space that yield WRs at a rate of >50% in spectroscopic follow-up. Candidates that are not WRs are mainly Be stars, which is possibly attributable to the physical similarities between the free-free emission parameters of Be disks and WR winds. As an additional selection experiment, the list of WR candidates was cross-correlated with archival X-ray point-source catalogs, which increases the WR detection rate of the broad color space to {approx}40%; 10 new WR X-ray sources have been found in addition to a previously unrecognized X-ray counterpart to a known WR. The extinction values, distances, and Galactocentric radii of all new WRs are calculated using the method of spectroscopic parallax. Although the majority of the new WRs have no obvious association with stellar clusters, two WC8 stars reside in a previously unknown massive-star cluster, in which five OB supergiants were also identified. The new system lies at an estimated distance of {approx}6.1 kpc, near the intersection of the Scutum-Centaurus Arm with the Galaxy's bar. In addition, two WC and four WN stars, all but one of which are X-ray sources, were identified in association with the stellar clusters Danks 1 and 2. A WN9 star has also been associated with the cluster

  10. Red Eyes on Wolf-Rayet Stars: 60 New Discoveries via Infrared Color Selection

    NASA Astrophysics Data System (ADS)

    Mauerhan, Jon C.; Van Dyk, Schuyler D.; Morris, Patrick W.

    2011-08-01

    We have spectroscopically identified 60 Galactic Wolf-Rayet (WR) stars, including 38 nitrogen types (WN) and 22 carbon types (WC). Using photometry from the Spitzer/GLIMPSE and Two Micron All Sky Survey databases, the new WRs were selected via a method we have established that exploits their unique infrared colors, which is mainly the result of excess radiation generated by free-free scattering within their dense ionized winds. The selection criterion has been refined since the last report, resulting in a WR detection rate of ≈20% in spectroscopic follow-up of candidates that comprise a broad color space defined by the color distribution of all known WRs having B > 14 mag. However, there are smaller regions within this color space that yield WRs at a rate of >50% in spectroscopic follow-up. Candidates that are not WRs are mainly Be stars, which is possibly attributable to the physical similarities between the free-free emission parameters of Be disks and WR winds. As an additional selection experiment, the list of WR candidates was cross-correlated with archival X-ray point-source catalogs, which increases the WR detection rate of the broad color space to ≈40% 10 new WR X-ray sources have been found in addition to a previously unrecognized X-ray counterpart to a known WR. The extinction values, distances, and Galactocentric radii of all new WRs are calculated using the method of spectroscopic parallax. Although the majority of the new WRs have no obvious association with stellar clusters, two WC8 stars reside in a previously unknown massive-star cluster, in which five OB supergiants were also identified. The new system lies at an estimated distance of ≈6.1 kpc, near the intersection of the Scutum-Centaurus Arm with the Galaxy's bar. In addition, two WC and four WN stars, all but one of which are X-ray sources, were identified in association with the stellar clusters Danks 1 and 2. A WN9 star has also been associated with the cluster [DBS2003] 179. This work

  11. An in flight investigation of pitch rate flight control systems and application of frequency domain and time domain predictive criteria

    NASA Technical Reports Server (NTRS)

    Berthe, C. J.; Chalk, C. R.; Sarrafian, S.

    1984-01-01

    The degree of attitude control provided by current integral-proportional pitch rate command-type control systems, while a prerequisite for flared landing, is insufficient for 'Level 1' performance. The pilot requires 'surrogate' feedback cues to precisely control flight path in the landing flare. Monotonic stick forces and pilot station vertical acceleration are important cues which can be provided by means of angle-of-attack and pitch rate feedback in order to achieve conventional short period and phugoid characteristics. Integral-proportional pitch rate flight control systems can be upgraded to Level 1 flared landing performance by means of lead/lag and washout prefilters in the command path. Strong pilot station vertical acceleration cues can provide Level 1 flared landing performance even in the absence of monotonic stick forces.

  12. Non-fatal work-related motor vehicle traffic crash injuries in New Zealand: analysis of a national claims database.

    PubMed

    Sultana, Shaheen; Robb, Gillian; Ameratunga, Shanthi; Jackson, Rod T

    2007-12-14

    This study describes event rates and associated costs from non-fatal work-related motor vehicle traffic crash (WR MVTC) injuries on public roads in New Zealand based on an analysis of the Accident Compensation Corporation (ACC) entitlement claims database. WR MVTC injury claims between July 2004 and June 2006 were identified from the ACC Motor Vehicle Account. Cross-sectional analyses were performed to describe the characteristics of the claims. Injury rates were estimated where appropriate. The overall age-standardised rate of non-fatal WR MVTC injury claims during the study period was 109 per 100,000 workers per year. The majority of claimants were male (75%) and New Zealand (NZ) European (67%), and one in three of these injuries occurred among plant and machine operators and assemblers. In contrast to rates of road traffic injury resulting in deaths and hospital admissions in NZ, younger and older workers had similar proportionate representation in the claims data. The total cost associated with the 1968 claims made during the 12 months from July 2004 to June 2005 was approximately NZ$6 million, with an average cost per claim of NZ$2884. To our knowledge this is the first published analysis of non-fatal WR MVTC injury claims in New Zealand. These analyses identify industry and demographic groups that appear to be at increased risk of WR MVTC injuries that could be targeted for preventive interventions. However, a number of limitations in the database, including uncertainties regarding the definition and coding of crashes deemed as "work-related", under-reporting of claims, and lack of a reliable indicator of injury severity significantly compromised our ability to interpret the results. Considerable improvement in the quality and reporting of claims data is required to facilitate the utility of this information to inform injury prevention strategies.

  13. Angiotensin-converting enzyme inhibition improves cardiac fatty acid metabolism in patients with congestive heart failure.

    PubMed

    Yamauchi, S; Takeishi, Y; Minamihaba, O; Arimoto, T; Hirono, O; Takahashi, H; Miyamoto, T; Nitobe, J; Nozaki, N; Tachibana, H; Watanabe, T; Fukui, A; Kubota, I

    2003-08-01

    This study aimed to examine whether angiotensin-converting enzyme (ACE) inhibition improved cardiac fatty acid metabolism in patients with congestive heart failure (CHF). Myocardial 123I-beta-methyl-iodophenylpentadecanoic acid (123I-BMIPP) imaging was performed in 25 patients with CHF and in 10 control subjects. Myocardial 123I-BMIPP images were obtained 30 min and 4 h after tracer injection. The heart-to-mediastinum (H/M) ratio of 123I-BMIPP uptake and the washout rate of 123I-BMIPP from the myocardium were calculated. Patients were given enalapril for 6 months, and 123I-BMIPP imaging was repeated. H/M ratios on early and delayed images were lower in CHF patients than in normal controls (P<0.01). The washout rate of 123I-BMIPP from the myocardium was faster in CHF patients than in controls (P<0.01). As the severity of the New York Heart Association (NYHA) functional class increased, the H/M ratio decreased and the washout rate increased. The washout rate of 123I-BMIPP was inversely correlated with left ventricular fractional shortening (R=-0.62, P<0.01). ACE inhibition with enalapril increased the H/M ratio on delayed images (P<0.05) and reduced the washout rate of 123I-BMIPP (P<0.05) in CHF patients. These data suggest that: (1) angiotensin II-mediated intracellular signalling activation may be a possible mechanism for the decreased myocardial uptake and enhanced washout of 123I-BMIPP in heart failure patients; and (2) the improvement in fatty acid metabolism by ACE inhibition may represent a new mechanism for the beneficial effect of this therapy in heart failure.

  14. A deep near-infrared spectroscopic survey of the Scutum-Crux arm for Wolf-Rayet stars

    NASA Astrophysics Data System (ADS)

    Rosslowe, C. K.; Crowther, Paul A.

    2018-01-01

    We present a New Technology Telescope/Son-of-Isaac spectroscopic survey of infrared selected Wolf-Rayet (WR) candidates in the Scutum-Crux spiral arm (298° ≤ l ≤ 340°, |b| ≤ 0.5°. We obtained near-IR spectra of 127 candidates, revealing 17 WR stars - a ∼13 per cent success rate - of which 16 are newly identified here. The majority of the new WR stars are classified as narrow-lined WN5-7 stars, with two broad-lined WN4-6 stars and three WC6-8 stars. The new stars, with distances estimated from previous absolute magnitude calibrations, have no obvious association with the Scutum-Crux arm. Refined near-infrared (YHJK) classification criteria based on over a hundred Galactic and Magellanic Cloud WR stars, providing diagnostics for hydrogen in WN stars, plus the identification of WO stars and intermediate WN/C stars. Finally, we find that only a quarter of WR stars in the survey region are associated with star clusters and/or H II regions, with similar statistics found for luminous blue variables (LBVs) in the Milky Way. The relative isolation of evolved massive stars is discussed, together with the significance of the co-location of LBVs and WR stars in young star clusters.

  15. Assessment of antiradiation drug effectiveness to fission neutron irradiation. Annual report No. 1, April-August 1981

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sigdestad, C.P.

    1981-09-01

    This report deals with the assays of various compounds for their toxicity of anti-radiation efficacy following exposure to either Co-60 or fission neutron irradiation. The compounds reported herein include WR 347, WR 2721, WR 3689, WR 44923, WR 109342, WR 151327, WR 16843, and WR 176542. The end-points measured in the radiation studies were LD50(6) and LD50(30). The compounds and their dose modification factors (DMF) for the neutron LD50(6) following i.p. administration, were, in descending order of effectiveness: WR 151327 (1.42), WR 347 (1.37), WR 3689 (1.34) WR 44923 (1.34), WR 2721 (1.26), WR 168643 (1.24), and WR 176542 (1.23).more » The corresponding LD50(30)'s for fission neutron irradiation following i.p. administration, were: WR 168643 (1.67), WR 3689 (1.52), WR 151327 (1.45), WR 44923 (1.39), WR 347 (1.22), WR 2721 (1.21), and WR 176542 (1.18). For low LET Co-60 gamma irradiation the LD50(6) and LD50(30) were determined for WR 347 following i.p. administration. The DMF's obtained were: LD50(6) (1.4), LD50(30) (1.5).« less

  16. Purification and characterization of the extracellular laccase produced by Trametes polyzona WR710-1 under solid-state fermentation.

    PubMed

    Chairin, Thanunchanok; Nitheranont, Thitinard; Watanabe, Akira; Asada, Yasuhiko; Khanongnuch, Chartchai; Lumyong, Saisamorn

    2014-01-01

    Laccase from Trametes polyzona WR710-1 was produced under solid-state fermentation using the peel from the Tangerine orange (Citrus reticulata Blanco) as substrate, and purified to homogeneity. This laccase was found to be a monomeric protein with a molecular mass of about 71 kDa estimated by SDS-PAGE. The optimum pH was 2.0 for ABTS, 4.0 for L-DOPA, guaiacol, and catechol, and 5.0 for 2,6-DMP. The K(m) value of the enzyme for the substrate ABTS was 0.15 mM, its corresponding V(max) value was 1.84 mM min(-1), and the k(cat)/K(m) value was about 3960 s(-1)  mM(-1). The enzyme activity was stable between pH 6.0 and 8.0, at temperatures of up to 40 °C. The laccase was inhibited by more than 50% in the presence of 20 mM NaCl, by 95% at 5 mM of Fe(2+), and it was completely inhibited by 0.1 mM NaN(3). The N-terminal amino acid sequence of this laccase is AVTPVADLQISNAGISPDTF, which is highly similar to those of laccases from other white-rot basidiomycetes. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Clinical application of inert gas Multiple Breath Washout in children and adolescents with asthma.

    PubMed

    Zwitserloot, Annelies; Fuchs, Susanne I; Müller, Christina; Bisdorf, Kornelia; Gappa, Monika

    2014-09-01

    Children with asthma often have normal spirometry despite significant disease. The pathology of the small airways in asthma may be assessed using Multiple Breath Washout (MBW) and calculating the Lung Clearance Index (LCI). There are only few studies using MBW in children with asthma and existing data regarding bronchodilator effect are contradictory. The aim of the present pilot study was to compare LCI in asthma and controls and assess the effect of salbutamol in children with asthma on the LCI. Unselected patients with a diagnosis of asthma visiting the outpatient department of our hospital between 04-2010 and 03-2011 were recruited and compared to a healthy control group. MBW was performed as inert gas MBW using sulfurhexafluorid (SF6) as the tracer gas. Clinical data were documented and spirometry and MBW (EasyOne Pro, MBW module, NDD Switzerland) were performed before and after the use of salbutamol (200-400 μg). Healthy controls performed baseline MBW only. 32 children diagnosed with asthma (4.7-17.4 years) and 42 controls (5.3-20.8) were included in the analysis. LCI differed between patients and controls, with a mean LCI (SD) of 6.48 (0.48) and 6.21 (0.38) (P = 0.008). Use of salbutamol had no significant effect on LCI for the group. These pilot data show that clinically stable asthma patients and controls both have a LCI in the normal range. However, in patients the LCI is significantly higher indicating that MBW may have a role in assessing small airways disease in asthma. Copyright © 2014 Elsevier Ltd. All rights reserved.

  18. Effects of Spinal Cord Stimulation on Cardiac Sympathetic Nerve Activity in Patients with Heart Failure.

    PubMed

    Naar, Jan; Jaye, Deborah; Linde, Cecilia; Neužil, Petr; Doškář, Petr; Málek, Filip; Braunschweig, Frieder; Lund, Lars H; Mortensen, Lars; Linderoth, Bengt; Lind, Göran; Bone, Dianna; Scholte, Arthur J; Kueffer, Fred; Koehler, Jodi; Shahgaldi, Kambiz; Lang, Otto; Ståhlberg, Marcus

    2017-05-01

    Spinal cord stimulation (SCS) reduces sympathetic activity in animal models of heart failure with reduced ejection fraction (HF) but limited data exist of SCS in patients with HF. The aim of the present study was to test the primary hypothesis that SCS reduces cardiac sympathetic nerve activity in HF patients. Secondary hypotheses were that SCS improves left ventricular function and dimension, exercise capacity, and clinical variables relevant to HF. HF patients with a SCS device previously participating in the DEFEAT-HF trial were included in this crossover study with 6-week intervention periods (SCS-ON and SCS-OFF). SCS (50 Hz, 210-μs pulse duration, aiming at T2-T4 segments) was delivered for 12 hours daily. Indices of myocardial sympathetic neuronal function (heart-to-mediastinum ratio, HMR) and activity (washout rate, WR) were assessed using 123 I-metaiodobenzylguanidine (MIBG) scintigraphy. Echocardiography, exercise testing, and clinical data collection were also performed. We included 13 patients (65.3 ± 8.0 years, nine males) and MIBG scintigraphy data were available in 10. HMR was not different comparing SCS-ON (1.37 ± 0.16) and SCS-OFF (1.41 ± 0.21, P = 0.46). WR was also unchanged comparing SCS-ON (41.5 ± 5.3) and SCS-OFF (39.1 ± 5.8, P = 0.30). Similarly, average New York Heart Association class (2.4 ± 0.5 vs 2.3 ± 0.6, P = 0.34), quality of life score (24 ± 16 vs 24 ± 16, P = 0.94), and left ventricular dimension and function as well as exercise capacity were all unchanged comparing SCS-ON and SCS-OFF. In patients with HF, SCS (12 hours daily, targeting the T2-T4 segments of the spinal cord) does not appear to influence cardiac sympathetic neuronal activity or function as assessed by MIBG scintigraphy. © 2017 Wiley Periodicals, Inc.

  19. ORACLE (Oversight of Resources and Capability for Logistics Effectiveness) and Requirements Forecasting. Volume 3. Predicting the Peacetime Spares Requirements.

    DTIC Science & Technology

    1988-05-01

    Shearing Machines WR/MMI DG 3446 Forging Machinery and Hammers WR/MMI DG 3447 Wire and Metal Ribbon Forming Machines WR/MMI DG 3448 Riveting Machines ...R/MN1I DG 3449 Miscellaneous Secondary Metal Forming & Cutting WR/MMI DG Machinery 3450 Machine Tools, Portable WR/MMI DG 3455 Cutting Tools for...Secondary Metalworking Machinery WR/MMI DG WR 3465 Production Jigs, Fixtures and Templates WR/MMI DG WR 3470 Machine Shop Sets, Kits, and Outfits WR/MMI DG

  20. Prognostic significance of contrast-enhanced CT attenuation value in extrahepatic cholangiocarcinoma.

    PubMed

    Asayama, Yoshiki; Nishie, Akihiro; Ishigami, Kousei; Ushijima, Yasuhiro; Takayama, Yukihisa; Okamoto, Daisuke; Fujita, Nobuhiro; Ohtsuka, Takao; Yoshizumi, Tomoharu; Aishima, Shinichi; Oda, Yoshinao; Honda, Hiroshi

    2017-06-01

    To determine whether washout characteristics of dynamic contrast-enhanced computed tomography (CT) could predict survival in patients with extrahepatic cholangiocarcinoma (EHC). This study collected 46 resected cases. All cases were examined by dynamic contrast study on multidetector-row CT. Region-of-interest measurements were obtained at the non-enhanced, portal venous phase and delayed phase in the tumour and were used to calculate the washout ratio as follows: [(attenuation value at portal venous phase CT - attenuation value at delayed enhanced CT)/(attenuation value at portal venous phase CT - attenuation value at unenhanced CT)] × 100. On the basis of the median washout ratio, we classified the cases into two groups, a high-washout group and low-washout group. Associations between overall survival and various factors including washout rates were analysed. The median washout ratio was 29.4 %. Univariate analysis revealed that a lower washout ratio, venous invasion, lymphatic permeation and lymph node metastasis were associated with shorter survival. Multivariate analysis identified the lower washout ratio as an independent prognostic factor (hazard ratio, 3.768; p value, 0.027). The washout ratio obtained from the contrast-enhanced CT may be a useful imaging biomarker for the prediction of survival of patients with EHC. • Dynamic contrast study can evaluate the aggressiveness of extrahepatic cholangiocarcinoma. • A lower washout ratio was an independent prognostic factor for overall survival. • CT can predict survival and inform decisions on surgical options or chemotherapy.

  1. The effect of water restriction on physiological and blood parameters on lactating dairy cows reared under Mediterranean climate.

    PubMed

    Benatallah, Amel; Ghozlane, Faissal; Marie, Michel

    2018-05-31

    This study was conducted to evaluate the effect of water restriction (WR) on physiological and blood parameters on lactating dairy cows reared under Mediterranean climate. The trial lasted 16 days preceded by two weeks of adaptation to the experimental condition in spring 2014 on 6 dairy cows in mid-lactation. These cows were watered at will for 4 days (W100) (hydration period), then split into 2 groups, one group has received 25% and the other 50% of water compared to their mean water consumption during the hydration period; then rehydrated for 4 days. Feed intake and physiological parameters: respiratory rate (RR), heart rate (HR) and rectal temperature (RT) were recorded twice a day. Par cons, the blood was collected once a day and analyzed for serum concentration of glucose (Glc), triglycerides (TG), cholesterol (Chol), urea (Ur), creatinine (Crea) and total protein (TP) by enzymatic colorimetric method and cortisol (Cort) by radioimmunoassay (RIA). Total dry matter intake (TDMI) was affected by WR. In fact, a decrease in TDMI was observed in WR groups compared to W100 group (effect, group, period, day, group x day, period x day: p<0.001). Also, WR resulted in a significant increase in RR, HR, RT in WR groups than in W100 group (effect, group: p<0.001). In addition, an increase in the serum concentration of Glc, TG, Chol, Ur, Crea, TP and Cort was noted in WR groups (effect, group, period, day: p<0.001) . This study has shown the ability of cows raised in a Mediterranean climate to cope with different levels of water restriction and thus reach a new equilibrium. As result, the important role of water as a limiting factor for livestock in environments with low water availability.

  2. Final Environmental Assessment: C-17 Program Changes Altus Air Force Base, Oklahoma

    DTIC Science & Technology

    2004-07-01

    speed aircraft on MTRs showed that there is little probability of structural damage from such operations ( Sutherland 1989). One finding in that...October. Plotkin, K.J., 1996. PCBoom3 Sonic Boom Prediction Model: Version 1.0c. Wyle Research Report WR 95-22C. May. Plotkin, K.J., Sutherland ...Rate on Aircraft Noise Annoyance. Volume 3: Hybrid Own-Home Experiment. Wyle Laboratories Research Report WR 93-22. December. Sutherland , L

  3. Multiple breath washout with a sidestream ultrasonic flow sensor and mass spectrometry: a comparative study.

    PubMed

    Fuchs, Susanne I; Buess, Christian; Lum, Sooky; Kozlowska, Wanda; Stocks, Janet; Gappa, Monika

    2006-12-01

    Over recent years, there has been renewed interest in the multiple breath wash-out (MBW) technique for assessing ventilation inhomogeneity (VI) as a measure of early lung disease in children. While currently considered the gold standard, use of mass spectrometry (MS) to measure MBW is not commercially available, thereby limiting widespread application of this technique. A mainstream ultrasonic flow sensor was marketed for MBW a few years ago, but its use was limited to infants. We have recently undertaken intensive modifications of both hardware and software for the ultrasonic system to extend its use for older children. The aim of the current in vivo study was to compare simultaneous measurements of end-tidal tracer gas concentrations and lung clearance index (LCI) from this modified ultrasonic device with those from a mass spectrometer. Paired measurements of three MBW, using 4% sulfur hexafluoride (SF(6)) as the tracer gas and the two systems in series, were obtained in nine healthy adult volunteers. End-tidal tracer gas concentrations (n = 675 paired values) demonstrated close agreement (95% CI of difference -0.23; -0.17%, r(2) = 1). FRC was slightly higher from the MS (95%CI 0.08;0.17 L), but there was no difference in LCI (95%CI -0.10; 0.3). We conclude, that this ultrasonic prototype system measures end-tidal tracer gas concentration accurately and may therefore be a valid tool for MBW beyond early childhood. This prototype system could be the basis for a commercial device allowing more widespread application of MBW in the near future.

  4. Highly reliable wind-rolling triboelectric nanogenerator operating in a wide wind speed range

    PubMed Central

    Yong, Hyungseok; Chung, Jihoon; Choi, Dukhyun; Jung, Daewoong; Cho, Minhaeng; Lee, Sangmin

    2016-01-01

    Triboelectric nanogenerators are aspiring energy harvesting methods that generate electricity from the triboelectric effect and electrostatic induction. This study demonstrates the harvesting of wind energy by a wind-rolling triboelectric nanogenerator (WR-TENG). The WR-TENG generates electricity from wind as a lightweight dielectric sphere rotates along the vortex whistle substrate. Increasing the kinetic energy of a dielectric converted from the wind energy is a key factor in fabricating an efficient WR-TENG. Computation fluid dynamics (CFD) analysis is introduced to estimate the precise movements of wind flow and to create a vortex flow by adjusting the parameters of the vortex whistle shape to optimize the design parameters to increase the kinetic energy conversion rate. WR-TENG can be utilized as both a self-powered wind velocity sensor and a wind energy harvester. A single unit of WR-TENG produces open-circuit voltage of 11.2 V and closed-circuit current of 1.86 μA. Additionally, findings reveal that the electrical power is enhanced through multiple electrode patterns in a single device and by increasing the number of dielectric spheres inside WR-TENG. The wind-rolling TENG is a novel approach for a sustainable wind-driven TENG that is sensitive and reliable to wind flows to harvest wasted wind energy in the near future. PMID:27653976

  5. Genetic Bases of Fungal White Rot Wood Decay Predicted by Phylogenomic Analysis of Correlated Gene-Phenotype Evolution.

    PubMed

    Nagy, László G; Riley, Robert; Bergmann, Philip J; Krizsán, Krisztina; Martin, Francis M; Grigoriev, Igor V; Cullen, Dan; Hibbett, David S

    2017-01-01

    Fungal decomposition of plant cell walls (PCW) is a complex process that has diverse industrial applications and huge impacts on the carbon cycle. White rot (WR) is a powerful mode of PCW decay in which lignin and carbohydrates are both degraded. Mechanistic studies of decay coupled with comparative genomic analyses have provided clues to the enzymatic components of WR systems and their evolutionary origins, but the complete suite of genes necessary for WR remains undetermined. Here, we use phylogenomic comparative methods, which we validate through simulations, to identify shifts in gene family diversification rates that are correlated with evolution of WR, using data from 62 fungal genomes. We detected 409 gene families that appear to be evolutionarily correlated with WR. The identified gene families encode well-characterized decay enzymes, e.g., fungal class II peroxidases and cellobiohydrolases, and enzymes involved in import and detoxification pathways, as well as 73 gene families that have no functional annotation. About 310 of the 409 identified gene families are present in the genome of the model WR fungus Phanerochaete chrysosporium and 192 of these (62%) have been shown to be upregulated under ligninolytic culture conditions, which corroborates the phylogeny-based functional inferences. These results illuminate the complexity of WR and suggest that its evolution has involved a general elaboration of the decay apparatus, including numerous gene families with as-yet unknown exact functions. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  6. X ray emission from Wolf-Rayet stars with recurrent dust formation

    NASA Technical Reports Server (NTRS)

    Rawley, Gayle L.

    1993-01-01

    We were granted a ROSAT observation of the Wolf-Rayet star WR 137 (equals HD 192641) to test a proposed mechanism for producing the infrared variability reported by Williams et al. (1987). These studies showed one clear infrared outburst preceded by what may be the dimming of a previous outburst. The recurrent dust formation model was put forward by Williams et al. (1990) to account for similar variability seen in WR 140, which varies in both the infrared and X-ray bands. The detected X-ray flux from WR 140 was observed to decrease from its normally high (for Wolf-Rayet stars) level as the infrared flux increased. Observation of two apparently-periodic infrared outbursts led to the hypothesis that WR 140 had an O star companion in an eccentric orbit, and that the increase in infrared flux came from a dust formation episode triggered by the compression of the O star and Wolf-Rayet star winds. The absorption of the X-rays by the increased material explained the decrease in flux at those wavelengths. If the infrared variability in WR 137 were caused by a similar interaction of the Wolf-Rayet star with a companion, we might expect that WR 137 would show corresponding X-ray variability and an X-ray luminosity somewhat higher than typical WC stars, as well as a phase-dependent non-thermal X-ray spectrum. Our goals in this study were to obtain luminosity estimates from our counting rates for comparison with previous observations of WR 137 and other WC class stars, especially WR 140; to compare the luminosity with the IR lightcurve; and to characterize the spectral shape of the X-ray emission, including the column density.

  7. Potential Application of Shallow Bed Wetland Roof systems for green urban cities

    NASA Astrophysics Data System (ADS)

    Bui, X. T.

    2016-12-01

    This study aims to investigate the growth, nutrient uptake, domestic wastewater treatment, green (leaf) area and heat reduction of four shallow subsurface flow wetland roof (WR) systems with four different new local plants. Selected species included Cyperus Javanicus Hot (WR1), Eleusine Indica (L.) Gaertn (WR2), Struchium Sparganophorum (L.) Kuntze (WR3) and Kyllinga Brevifolia Rottb (WR4). These systems were operated during 61 days at hydraulic loading rates of 353 - 403 m3/ha.day. The biomass growth of 4.9-73.7g fresh weight/day, and 0.8-11.4 g dry weight/day were observed. The nutrient accumulation according to dry biomass achieved 0.25-2.14% of total nitrogen (TN) and 0.13-1.07% of total phosphorus (TP). The average COD, TN and TP removal was 61-79%; 54-81% and 62-83%, which corresponding to 27-33 kg COD/ha.day, 10-14 kg TN/ha.day and 0.4-0.5 kg TP/ha.day, respectively. The WR4 system achieved the highest COD and TN removal among the WRs. The TP removal efficiency showed an insignificant difference for the systems. Consequently, the treated water quality complied with the Vietnam standard limits (QCVN 14:2008, level B). The green area of the four plants varied between 63-92 m2 green leaf/m2 WR. The WR4 was the highest green area. Moreover, the results also showed the temperature under the flat roof was 1-3°C lower than that of the ambient air. In summary, wetland roof is a promising technology, which not only owns the effective domestic wastewater treatment capacity, but also contributes to green urban with several above benefits.

  8. Infant multiple breath washout using a new commercially available device: Ready to replace the previous setup?

    PubMed

    Kentgens, Anne-Christianne; Guidi, Marisa; Korten, Insa; Kohler, Lena; Binggeli, Severin; Singer, Florian; Latzin, Philipp; Anagnostopoulou, Pinelopi

    2018-05-01

    Multiple breath washout (MBW) is a sensitive test to measure lung volumes and ventilation inhomogeneity from infancy on. The commonly used setup for infant MBW, based on ultrasonic flowmeter, requires extensive signal processing, which may reduce robustness. A new setup may overcome some previous limitations but formal validation is lacking. We assessed the feasibility of infant MBW testing with the new setup and compared functional residual capacity (FRC) values of the old and the new setup in vivo and in vitro. We performed MBW in four healthy infants and four infants with cystic fibrosis, as well as in a Plexiglas lung simulator using realistic lung volumes and breathing patterns, with the new (Exhalyzer D, Spiroware 3.2.0, Ecomedics) and the old setup (Exhalyzer D, WBreath 3.18.0, ndd) in random sequence. The technical feasibility of MBW with the new device-setup was 100%. Intra-subject variability in FRC was low in both setups, but differences in FRC between the setups were considerable (mean relative difference 39.7%, range 18.9; 65.7, P = 0.008). Corrections of software settings decreased FRC differences (14.0%, -6.4; 42.3, P = 0.08). Results were confirmed in vitro. MBW measurements with the new setup were feasible in infants. However, despite attempts to correct software settings, outcomes between setups were not interchangeable. Further work is needed before widespread application of the new setup can be recommended. © 2018 Wiley Periodicals, Inc.

  9. Expanding the "Active Layer": Discussion of Church and Haschenburger (2017) What is the "Active Layer"? Water Resources Research 53, 5-10, Doi:10.1002/2016WR019675

    NASA Astrophysics Data System (ADS)

    Ashmore, Peter; Peirce, Sarah; Leduc, Pauline

    2018-03-01

    Church and Haschenburger (2017, https://doi.org/10.1002/2016WR019675) make helpful distinctions around the issue of defining the active layer, with which we agree. We propose expanding discussion and definition of the "active layer" in fluvial bedload transport to include the concept of the "morphological active layer." This is particularly applicable to laterally unstable rivers (such as braided rivers) in which progressive morphological change over short time periods is the process by which much of the bedload transport occurs. The morphological active layer is also distinguished by variable lateral and longitudinal extent continuity over a range of flows and transport intensity. We suggest that the issue of forms of active layer raised by Church and Haschenburger opens up an important discussion on the nature of bedload transport in relation to river morpho-dynamics over the range of river types.

  10. Cardiorespiratory demand of acute voluntary cycling with functional electrical stimulation in individuals with multiple sclerosis with severe mobility impairment.

    PubMed

    Edwards, Thomas; Motl, Robert W; Pilutti, Lara A

    2018-01-01

    Exercise training is one strategy for improving cardiorespiratory fitness (CRF) in multiple sclerosis (MS); however, few modalities are accessible for those with severe mobility impairment. Functional electrical stimulation (FES) cycling is an adapted exercise modality with the potential for improving CRF in people with severe MS. The objective of this study was to characterize the cardiorespiratory response of acute voluntary cycling with FES in people with MS with severe mobility impairment, and to compare this response to passive leg cycling. Eleven participants with MS that required assistance for ambulation completed a single bout of voluntary cycling with FES or passive leg cycling. Oxygen consumption, heart rate (HR), work rate (WR), and ratings of perceived exertion (RPE) were recorded throughout the session. For the FES group, mean exercising oxygen consumption was 8.7 ± 1.8 mL/(kg·min) -1 , or 63.5% of peak oxygen consumption. Mean HR was 102 ± 9.7 bpm, approximately 76.4% of peak HR. Mean WR was 27.0 ± 9.2 W, or 57.3% of peak WR, and median RPE was 13.5 (interquartile range = 5.5). Active cycling with FES was significantly (p < 0.05) more intense than passive leg cycling based on oxygen consumption, HR, WR, and RPE during exercise. In conclusion, voluntary cycling with FES elicited an acute response that corresponded with moderate-to vigorous-intensity activity, suggesting that active cycling with FES can elicit a sufficient stimulus for improving CRF.

  11. Dynamic 123I-BMIPP single-photon emission computed tomography in patients with congestive heart failure: effect of angiotensin II type-1 receptor blockade.

    PubMed

    Takeishi, Yasuchika; Minamihaba, Osamu; Yamauchi, Sou; Arimoto, Takanori; Hirono, Osamu; Takahashi, Hiroki; Akiyama, Hideyuki; Miyamoto, Takuya; Nitobe, Joji; Nozaki, Naoki; Tachibana, Hidetada; Okuyama, Masaki; Fukui, Akio; Kubota, Isao; Okada, Akio; Takahashi, Kazuei

    2004-04-01

    Heart failure is a major and growing public health problem with a high mortality rate. Although recent studies have demonstrated that a variety of metabolic and/or neurohumoral factors are involved in the progression of this syndrome, the precise mechanisms responsible for this complex condition are poorly understood. To examine 123I-beta-methyl-iodophenylpentadecanoic acid (BMIPP) kinetics in the early phase soon after tracer injection in patients with congestive heart failure (CHF), we performed dynamic single-photon emission computed tomography (SPECT). Twenty-six patients with CHF and eight control subjects were examined. The consecutive 15 images of 2-min dynamic SPECT were acquired for 30 min after injection. In the early phase after injection (0-4 min), a significant amount of radioactivity existed in the blood pool. After 6 min, the myocardial 123I-BMIPP image was clear and thus the washout rate of 123I-BMIPP from 6 to 30 min was calculated. The washout rate of 123I-BMIPP from the myocardium was faster in patients with CHF than in the controls (8 +/- 4 vs. -5 +/- 3%, p < 0.01). The washout rate of 123I-BMIPP demonstrated positive correlation with left ventricular (LV) end-diastolic volume index (R = 0.54, p < 0.02) and inverse correlation with LV ejection fraction (R = 0.53, p <0.02). Patients were given the angiotensin II type-1 receptor antagonist candesartan for 6 months, and dynamic SPECT was repeated. The enhanced washout rate of 123I-BMIPP in CHF was reduced after treatment with candesartan (p < 0.05). These data suggest that (1) enhanced washout of 123I-BMIPP was observed soon after injection in patients with CHF, (2) the activation of angiotensin II signaling pathway is involved as an intracellular mechanism for enhanced 123I-BMIPP washout in heart failure, and (3) improvement in fatty acid metabolism may represent a new mechanism for beneficial effects of angiotensin II receptor blockade on cardiac function and survival in patients with heart

  12. The washout effect during laundry on benzothiazole, benzotriazole, quinoline, and their derivatives in clothing textiles.

    PubMed

    Luongo, Giovanna; Avagyan, Rozanna; Hongyu, Ren; Östman, Conny

    2016-02-01

    In two previous papers, the authors have shown that benzothiazole, benzotriazole, quinoline, and several of their derivatives are widespread in clothing textile articles. A number of these compounds exhibit allergenic and irritating properties and, due to their octanol-water partition coefficient, are prone to be absorbed by the skin. Moreover, they are slightly soluble in water, which could make washing of clothes a route of emission into the environment. In the present study, the washout effect of benzothiazole, benzotriazole, quinoline, and some of their derivatives has been investigated. Twenty-seven textile samples were analyzed before, as well as after five and ten times of washing. The most abundant analyte was found to be benzothiazole, which was detected in 85 % of the samples with an average concentration of 0.53 μg/g (median 0.44 μg/g), followed by quinoline, detected in 81 % of the samples with an average concentration of 2.42 μg/g (median 0.21 μg/g). The average decrease in concentration for benzothiazoles was 50 % after ten times washing, while it was around 20 % for quinolines. The average emission to household wastewater of benzothiazoles and quinolines during one washing (5 kg of clothes made from polyester materials) was calculated to 0.5 and 0.24 g, respectively. These results strongly indicate that laundering of clothing textiles can be an important source of release of these compounds to household wastewater and in the end to aquatic environments. It also demonstrates a potential source of human exposure to these chemicals since considerable amounts of the compounds remain in the clothes even after ten times of washing.

  13. Hepatic Hemangiomas: Factors Associated with Pseudo Washout Sign on Gd-EOB-DTPA-enhanced MR Imaging.

    PubMed

    Tateyama, Akihiro; Fukukura, Yoshihiko; Takumi, Koji; Shindo, Toshikazu; Kumagae, Yuichi; Nakamura, Fumihiko

    2016-01-01

    Our study aim was to clarify the characteristics of hemangiomas with pseudo washout sign (PWS) by comparing their features with those of hemangiomas without PWS on gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) imaging. We evaluated the features of hemangiomas on Gd-EOB-DTPA-enhanced MR imaging of 70 hepatic hemangiomas in 31 patients, investigating the presence of peripheral or central nodular enhancement, diffuse enhancement, and arterioportal shunt during the arterial phase, fill-in enhancement during the portal venous phase, and PWS, which is low signal intensity during the late phase. We visually assessed the intensity of contrast enhancement of the lesion during the arterial, portal venous, late, and hepatobiliary phases using a 4-grade scale and used the Fisher exact and Mann-Whitney U tests to compare hemangiomas with and without PWS. We observed PWS in 33 (47%) of 70 hemangiomas, which were significantly smaller than the hemangiomas without PWS (17.4 mm ± 20.3 versus 30.1 mm ± 28.5; P = 0.005); more frequent diffuse enhancement in hemangiomas with PWS than those without (21.2% versus 2.7%; P = 0.026); and no significant differences in nodular enhancement (P = 0.231), arterioportal shunt (P = 0.403), or fill-in enhancement (P = 0.357) between hemangiomas with and without PWS. Visually determined grades of tumor contrast enhancement were significantly lower in hemangiomas with PWS during the portal venous (P = 0.007) and late (P < 0.001) phases. Small hemangiomas tend to decrease in signal intensity during the portal venous phase and show PWS during the late phase.

  14. Long-term performance of high-rate anaerobic reactors for the treatment of oily wastewater.

    PubMed

    Jeganathan, Jeganaesan; Nakhla, George; Bassi, Amarjeet

    2006-10-15

    Complex oily wastewater from a food industry was treated in three different UASB reactors at different operating conditions. Although all three systems achieved fat, oil, and grease (FOG) and COD removal efficiencies above 80% at an organic loading of 3 kg COD/m3 x d, system performance deteriorated sharply at higher loading rates, and the presence of high FOG caused a severe sludge flotation resulting in failure. Initially, FOG accumulated onto the biomass which led to sludge flotation and washout of biomass. The loss of sludge in the bed increased the FOG loading to the biomass and failure ensued. Contrary to previous findings, accumulation of FOG rather than influent FOG concentrations or volumetric FOG loading rate was the most importantfactor governing the high-rate anaerobic reactor performance. The critical accumulated FOG loading was identified as 1.04 +/- 0.13 g FOG/g VSS for all three reactors. Furthermore, FOG accumulation onto the biomass was identified mainly as palmitic acid (>60%) whereas the feed LCFA contained only 30% of palmitic acid and 50% of oleic acid.

  15. Predictors of post-partum weight retention in a prospective longitudinal study.

    PubMed

    Martin, Julia Elizabeth; Hure, Alexis Jayne; Macdonald-Wicks, Lesley; Smith, Roger; Collins, Clare Elizabeth

    2014-10-01

    Post-partum weight retention (WR) occurs in 60-80% of women with some retaining ≥10 kg with contributing factors reported as pre-pregnancy body mass index (BMI), gestational weight gain (GWG) and breastfeeding. A longitudinal study of pregnancy, with 12-month post-partum follow-up was conducted to determine factors associated with WR. Pregnant women (n = 152) were recruited from the John Hunter Hospital antenatal clinic in New South Wales, Australia. Pre-pregnancy weight was self-reported; weight was measured four times during pregnancy (for GWG) and in the first 12 months post-partum. Infant feeding data were obtained via questionnaires. Breastfeeding was categorised as exclusive, predominant, complementary or not breastfeeding. Linear mixed models tested the predictors of WR, with and without adjustment for potential confounders. Compared with pre-pregnancy weight, 68% of women retained weight at 12 months, median (interquartile range) [4.5 kg (2.1-8.9)]. After adjustment, GWG was positively associated with WR (P < 0.01), but pre-pregnancy weight did not predict WR. For each additional week of any breastfeeding, 0.04 kg less weight was retained. Compared with women who retained weight, those women who did retain had higher rates of exclusive breastfeeding at three months (P < 0.05), but the number of weeks of exclusive breastfeeding failed to predict WR for all women. WR following childbirth is common and associated with GWG, while the number of weeks of 'any' breastfeeding contributed to post-partum weight loss. Whether these factors are modifiable strategies to optimise the weight status of women at this life stage requires further research. © 2012 John Wiley & Sons Ltd.

  16. Radiological Impact of Tritium from Gaseous Effluent Releases at Cook Nuclear Power Plant

    NASA Astrophysics Data System (ADS)

    Young, Joshua Allan

    The purpose of this study was to investigate the washout of tritiated water by snow and rain from gaseous effluent releases at Donald C. Cook Nuclear Power Plant. Primary concepts studied were determination of washout coefficients for rainfall and snowfall; correlations between rainfall and snow fall tritium concentrations with tritium concentrations in the spent fuel pool, reactor cooling systems, and tritium release rates; and calculations of received doses from the process of recapture. The dose calculations are under the assumption of a maximally exposed individual to get the most conservative estimate of the effect that washout of tritiated water has on individuals around the plant site. This study is in addition to previous work that has been conducted at Cook Nuclear Power Plant for several years. The calculated washout coefficients were typically within the range of 1x10-7s -1 to 1x10-5s-1. A strong correlation between tritium concentration within the spent fuel pool and the tritium release rates was determined.

  17. Stationary hydrodynamic models of Wolf-Rayet stars with optically thick winds.

    NASA Astrophysics Data System (ADS)

    Heger, A.; Langer, N.

    1996-11-01

    We investigate the influence of a grey, optically thick wind on the surface and internal structure of Wolf-Rayet (WR) stars. We calculate hydrodynamic models of chemically homogeneous helium stars with stationary outflows, solving the full set of stellar structure equations from the stellar center up to well beyond the sonic point of the wind, including the line force originating from absorption lines in a parameterized way. For specific assumptions about mass loss rate and wind opacity above our outer boundary, we find that the iron opacity peak may lead to local super-Eddington luminosities at the sonic point. By varying the stellar wind parameters over the whole physically plausible range, we show that the radius of the sonic point of the wind flow is always very close to the hydrostatic stellar radius obtained in WR star models which ignore the wind. However, our models confirm the possibility of large values for observable WR radii and correspondingly small effective temperatures found in earlier models. We show further that the energy which is contained in a typical WR wind can not be neglected. The stellar luminosity may be reduced by several 10%, which has a pronounced effect on the mass-luminosity relation, i. e., the WR masses derived for a given luminosity may be considerably larger. Thereby, also the momentum problem of WR winds is considerably reduced, as well as the scatter in the ˙(M) vs. M diagram for observed hydrogen-free WN stars.

  18. Estrellas Wolf-Rayet y el medio interestelar: huellas de una fuerte interacción

    NASA Astrophysics Data System (ADS)

    Cichowolski, S.; Arnal, E. M.

    Se presentan resultados observacionales de un estudio de la distribución de hidrógeno neutro en los alrededores de estrellas Wolf-Rayet (WR) galácticas. Los datos de la línea de 21 cm provienen de observaciones de resolución angular intermedia (9') tomadas con el radiotelescopio de Effelsberg. La muestra está compuesta por cuatro WR de la serie del nitrógeno (WN): WR130, WR131, WR155, WR156 y tres WR de la serie del carbono (WC): WR154, WR117 y WR126. Este análisis ha permitido detectar cavidades y envolturas de HI en expansión presumiblemente vinculadas a dichas estrellas.

  19. Improvement in antithrombogenicity in a centrifugal pump with self wash-out structure for long-term use.

    PubMed

    Wakisaka, Y; Taenaka, Y; Tatsumi, E; Araki, K; Masuzawa, T; Nakatani, T; Baba, Y; Anai, H; Eya, K; Toda, K

    1995-01-01

    Antithrombogenicity in the initial (NCVC-1) centrifugal pump (CP) developed at our institute is provided by a central balancing hole in an impeller that promotes self wash-out blood flow (Sf) around the impeller. The current CP (NCVC-2) was ameliorated to obtain better antithrombogenicity, where the balancing hole diameter was widened to improve Sf velocity (Vsf), and the edge of a thrust bearing (TB) was rounded to minimize flow separation. Effects of the modifications were assessed in in vitro and in vivo studies. The Vsf of the NCVC-1 and the NCVC-2 evaluated by Doppler velocimeter were 12.8 and 22.1 cm/sec, respectively. Flow around the TB visualized by a light cutting method confirmed less flow stagnation in the NCVC-2. In vivo antithrombogenicity of the CPs was investigated in three goats. A pulsatile VAD (P-VAD) was installed paracorporeally between the left atrium and the aorta. After 3 weeks, the P-VAD was exchanged for the NCVC-2 and the NCVC-1 in sequence. Each CP was driven for 1 week and disassembled. No anticoagulation was used, except for heparin injection at pump exchange. Thrombus at the TB was found in the two NCVC-1s, and two little thrombi were on the impeller of another NCVC-1, whereas a thrombus smaller than 1 mm3 at the TB was noted in one NCVC-2. These results indicate that the NCVC-2 has better antithrombogenicity and Sf around the impeller and the TB.

  20. Effects of self washout structure on the antithrombogenicity and the hemolytic properties of a centrifugal pump.

    PubMed

    Wakisaka, Y; Taenaka, Y; Araki, K; Chikanari, K; Nakatani, T; Baba, Y; Anai, H; Eya, K; Toda, K; Takano, H

    1997-02-01

    Antithrombogenicity in an initial type (N1) of a centrifugal pump (CP) developed in our institute is provided by the central balancing hole of an impeller. A new CP (N2) was modified to obtain better antithrombogenicity, in which the balancing hole was widened to improve self washout flow velocity (Vsf), and an edge of the thrust bearing was rounded off to minimize flow separation. Effects of the modifications were assessed in vitro and in vivo studies. The Vsf of the N1 and the N2 evaluated by a Doppler velocimeter were 12.8 and 22.1 cm/s, respectively. Flow around the thrust bearing, which was visualized by a light cutting method, confirmed less flow stagnation in the N2. The hemolytic indices of the N1 and the N2 were 0.023 and 0.008 mg/dl, respectively. In vivo antithrombogenicity and the hemolytic properties of the N2 and the N1 were investigated without anticoagulation therapy in 3 goats. In each goat the N2 was driven for 1 week and exchanged for the N1, which was driven for the same period. Red thrombi at the thrust bearing were found in 2 N1s, and 2 small thrombi were on the impeller of another N1, whereas a thrombus of less than 1 mm3 at the TB was noted in 1 N2. Plasma free hemoglobin was not increased in either CP. These results indicate that the N2 has better antithrombogenicity and hemolytic properties than the N1.

  1. The evolution of massive stars including mass loss - Presupernova models and explosion

    NASA Technical Reports Server (NTRS)

    Woosley, S. E.; Langer, Norbert; Weaver, Thomas A.

    1993-01-01

    The evolution of massive stars of 35, 40, 60, and 85 solar masses is followed through all stages of nuclear burning to the point of Fe core collapse. Critical nuclear reaction and mass-loss rates are varied. Efficient mass loss during the Wolf-Rayet (WR) stage is likely to lead to final masses as small as 4 solar masses. For a reasonable parameterization of the mass loss, there may be convergence of all WR stars, both single and in binaries, to a narrow band of small final masses. Our representative model, a 4.25 solar-mass WR presupernova derived from a 60 solar mass star, is followed through a simulated explosion, and its explosive nucleosynthesis and light curve are determined. Its properties are similar to those observed in Type Ib supernovae. The effects of the initial mass and mass loss on the presupernova structure of small mass WR models is also explored. Important properties of the presupernova star and its explosion can only be obtained by following the complete evolution starting on the main sequence.

  2. Synthesis of iron composites on nano-pore substrates: identification and its application to removal of cyanide.

    PubMed

    Do, Si-Hyun; Jo, Young-Hoon; Park, Ho-Dong; Kong, Sung-Ho

    2012-11-01

    Two types of nano-pore substrates, waste-reclaimed (WR) and soil mineral (SM) with the relatively low density, were modified by the reaction with irons (i.e. Fe(II):Fe(III)=1:2) and the applicability of the modified substrates (i.e. Fe-WR and Fe-SM) on cyanide removal was investigated. Modification (i.e. Fe immobilization on substrate) decreased the BET surface area and PZC of the original substrates while it increased the pore diameter and the cation exchange capacity (CEC) of them. XRD analysis identified that maghemite (γ-Fe(2)O(3)) and iron silicate composite ((Mg, Fe)SiO(3)) existed on Fe-WR, while clinoferrosilite (FeSiO(3)) was identified on Fe-SM. Cyanide adsorption showed that WR adsorbed cyanide more favorably than SM. The adsorption ability of both original substrates was enhanced by the modification, which increased the negative charges of the surfaces. Without the pH adjustment, cyanide was removed as much as 97% by the only application of Fe-WR, but the undesirable transfer to hydrogen cyanide was possible because the pH was dropped to around 7.5. With a constant pH of 12, only 54% of cyanide was adsorbed on Fe-WR. On the other hand, the pH was kept as 12 without adjustment in Fe-WR/H(2)O(2) system and cyanide was effectively removed by not only adsorption but also the catalytic oxidation. The observed first-order rate constant (k(obs)) for cyanide removal were 0.49 (± 0.081) h(-1). Moreover, the more cyanate production with the modified substrates indicated the iron composites, especially maghemite, on substrates had the catalytic property to increase the reactivity of H(2)O(2). Copyright © 2012 Elsevier Ltd. All rights reserved.

  3. Machine-learning approaches to select Wolf-Rayet candidates

    NASA Astrophysics Data System (ADS)

    Marston, A. P.; Morello, G.; Morris, P.; van Dyk, S.; Mauerhan, J.

    2017-11-01

    The WR stellar population can be distinguished, at least partially, from other stellar populations by broad-band IR colour selection. We present the use of a machine learning classifier to quantitatively improve the selection of Galactic Wolf-Rayet (WR) candidates. These methods are used to separate the other stellar populations which have similar IR colours. We show the results of the classifications obtained by using the 2MASS J, H and K photometric bands, and the Spitzer/IRAC bands at 3.6, 4.5, 5.8 and 8.0μm. The k-Nearest Neighbour method has been used to select Galactic WR candidates for observational follow-up. A few candidates have been spectroscopically observed. Preliminary observations suggest that a detection rate of 50% can easily be achieved.

  4. Radiation protection issues in galactic cosmic ray risk assessment.

    PubMed

    Sinclair, W K

    1994-01-01

    Radiation protection involves the limitation of exposure to below threshold doses for direct (or deterministic) effects and a knowledge of the risk of stochastic effects after low doses. The principal stochastic risk associated with low dose rate galactic cosmic rays is the increased risk of cancer. Estimates of this risk depend on two factors (a) estimates of cancer risk for low-LET radiation and (b) values of the appropriate radiation weighting factors, WR, for the high-LET radiations of galactic cosmic rays. Both factors are subject to considerable uncertainty. The low-LET cancer risk derived from the late effects of the atomic bombs is vulnerable to a number of uncertainties including especially that from projection in time, and from extrapolation from high to low dose rate. Nevertheless, recent low dose studies of workers and others tend to confirm these estimates. WR, relies on biological effects studied mainly in non-human systems. Additional laboratory studies could reduce the uncertainties in WR and thus produce a more confident estimate of the overall risk of galactic cosmic rays.

  5. Radiation protection issues in galactic cosmic ray risk assessment

    NASA Technical Reports Server (NTRS)

    Sinclair, W. K.

    1994-01-01

    Radiation protection involves the limitation of exposure to below threshold doses for direct (or deterministic) effects and a knowledge of the risk of stochastic effects after low doses. The principal stochastic risk associated with low dose rate galactic cosmic rays is the increased risk of cancer. Estimates of this risk depend on two factors (a) estimates of cancer risk for low-LET radiation and (b) values of the appropriate radiation weighting factors, WR, for the high-LET radiations of galactic cosmic rays. Both factors are subject to considerable uncertainty. The low-LET cancer risk derived from the late effects of the atomic bombs is vulnerable to a number of uncertainties including especially that from projection in time, and from extrapolation from high to low dose rate. Nevertheless, recent low dose studies of workers and others tend to confirm these estimates. WR, relies on biological effects studied mainly in non-human systems. Additional laboratory studies could reduce the uncertainties in WR and thus produce a more confident estimate of the overall risk of galactic cosmic rays.

  6. Evaluation of different types of anaerobic seed sludge for the high rate anaerobic digestion of pig slurry in UASB reactors.

    PubMed

    Rico, Carlos; Montes, Jesús A; Rico, José Luis

    2017-08-01

    Three different types of anaerobic sludge (granular, thickened digestate and anaerobic sewage) were evaluated as seed inoculum sources for the high rate anaerobic digestion of pig slurry in UASB reactors. Granular sludge performance was optimal, allowing a high efficiency process yielding a volumetric methane production rate of 4.1LCH 4 L -1 d -1 at 1.5days HRT (0.248LCH 4 g -1 COD) at an organic loading rate of 16.4gCODL -1 d -1 . The thickened digestate sludge experimented flotation problems, thus resulting inappropriate for the UASB process. The anaerobic sewage sludge reactor experimented biomass wash-out, but allowed high process efficiency operation at 3days HRT, yielding a volumetric methane production rate of 1.7LCH 4 L -1 d -1 (0.236LCH 4 g -1 COD) at an organic loading rate of 7.2gCODL -1 d -1 . To guarantee the success of the UASB process, the settleable solids of the slurry must be previously removed. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Polarization light curve modelling of corotating interaction regions in the wind of the Wolf-Rayet star WR 6

    NASA Astrophysics Data System (ADS)

    St-Louis, N.; Tremblay, Patrick; Ignace, Richard

    2018-02-01

    The intriguing WN4b star WR 6 has been known to display epoch-dependent spectroscopic, photometric and polarimetric variability for several decades. In this paper, we set out to verify if a simplified analytical model in which corotating interaction regions (CIRs) threading an otherwise spherical wind is able to reproduce the many broad-band continuum light curves from the literature with a reasonable set of parameters. We modified the optically thin model developed by Ignace, St-Louis & Proulx-Giraldeau to approximately account for multiple scattering and used it to fit 13 separate data sets of this star. By including two CIRs in the wind, we obtained reasonable fits for all data sets with coherent values for the inclination of the rotation axis (i0 = 166°) and for its orientation in the plane of the sky, although in the latter case we obtained two equally acceptable values (ψ = 63° and 152°) from the polarimetry. Additional line profile variation simulations using the Sobolev approximation for the line transfer allowed us to eliminate the ψ = 152° solution. With the adopted configuration (i0 = 166° and ψ = 63°), we were able to reproduce all data sets relatively well with two CIRs located near the stellar equator and always separated by ˜90° in longitude. The epoch dependence comes from the fact that these CIRs migrate along the surface of the star. Density contrasts smaller than a factor of 2 and large opening angles for the CIR (β ⪆ 35°) were found to best reproduce the type of spectroscopic variability reported in the literature.

  8. The relative importance of hydrophobicity in determining runoff-infiltration processes in burned forest soils

    NASA Astrophysics Data System (ADS)

    Wittenberg, Lea; Malkinson, Dan; Voogt, Annelies; Leska, Danny; Argaman, Eli; Keesstra, Saskia

    2010-05-01

    were taken in concentric circles around the burned trees at two soil depths. We complemented this investigation by conducting a series of laboratory simulations. Non-burned soil was taken for laboratory analysis and rainfall simulations. Four treatment types were conducted: non-burned soil, non-burned soil + pine needles, burned soil without ash (300°C/15 min. after adding pine needles) and burned soil with the residue ash (300°C/15 min. after adding pine needles). Hydrophobicity was measured in all trays. Constant rainfall intensity of 30 mm/hr was simulated until terminal infiltration rates were reached. The experimental trays were oven dried and simulated again to imitate the effect of second rainstorm. Preliminary results indicate strong surface WR (60% >180s) at a distance of 1m and at the subsurface (50% >180s) directly by the trunk. In the control non-burned site stronger WR was found in proximity to the trunks. While in the burned sites extreme values (>300s) were apparent (15-35%) and correlated with distance from the trunk, no corresponding patterns were noticed in the control trees. The attempt to create homogeneous layer of WR under controlled laboratory conditions yielded a scattered pattern of repellency, similar to the field conditions. In contrast to expected, the bare soil and bare soil covered by needles exhibited the highest and lowest infiltration rates, respectively, while the burned hydrophobic soils demonstrated intermediate rates. It is thus suggested that in some soils, WR might enhance infiltration capacity by creating a complex mosaic of runoff-generating and runoff-absorbing micro-patches. In the experimental non-burned soil a rapid crusting of the surface provided lateral connectivity whilst the accumulation of litter and organic matter blanket the surface and enhance the vertical conductivity. To better understand the role of WR in generating hydrological response, it is required to consider the 3D 'sponge like' properties of the WR

  9. Wolf-Rayet stars

    NASA Technical Reports Server (NTRS)

    Abbott, David C.; Conti, Peter S.

    1987-01-01

    The properties and evolutionary status of WR stars are examined, reviewing the results of recent observational and theoretical investigations. Topics discussed include spectral types and line strengths, magnitudes and colors, intrinsic variability, IR and radio observations, X-ray observations, the Galactic distribution of WR stars, WR stars in other galaxies, and WR binaries. Consideration is given to the inferred masses, composition, and stellar winds of WR stars; model atmospheres; WR stars and the Galactic environment; and WR stars as a phase of stellar evolution. Diagrams, graphs, and tables of numerical data are provided.

  10. New method to calculate the N2 evolution from mixed venous blood during the N2 washout.

    PubMed

    Han, D; Jeng, D R; Cruz, J C; Flores, X F; Mallea, J M

    2001-08-01

    To model the normalized phase III slope (Sn) from N2 expirograms of the multibreath N2 washout is a challenge to researchers. Experimental measurements show that Sn increases with the number of breaths. Previously, we predicted Sn by setting the concentration (atm) of mixed venous blood (Fbi,N2) to a constant value of 0.3 after the fifth breath to calculate the amount of N2 transferred from the blood to the alveoli. As a consequence, the predicted curve of the Sn values showed a maximum before the quasi-steady state was reached. In this paper, we present a way of calculating the amount of N2 transferred from the blood to the alveoli by setting Fbi,N2 in the following way: In the first six breaths Fbi,N2 is kept constant at the initial value of 0.8 because circulation time needs at least 30 s to alter it. Thereafter, a single exponential function with respect the number of breaths is used: Fbi = 0.8 exp[0.112(6-n)], in which n is the breath number. The predicted Sn values were compared with experimental data from the literature. The assumption of an exponential decay in the N2 evolved from mixed venous blood is important in determining the shape of the Sn curve but new experimental data are needed to determine the validity of the model. We concluded that this new approach to calculate the N2 evolution from the blood is more meaningful physiologically.

  11. Kinetic study of benzyl [1-14C]acetate as a potential probe for astrocytic energy metabolism in the rat brain: Comparison with benzyl [2-14C]acetate.

    PubMed

    Okada, Maki; Yanamoto, Kazuhiko; Kagawa, Tomohiko; Yoshino, Keiko; Hosoi, Rie; Abe, Kohji; Zhang, Ming-Rong; Inoue, Osamu

    2016-02-01

    Brain uptake of [(14)C]acetate has been reported to be a useful marker of astrocytic energy metabolism. In addition to uptake values, the rate of radiolabeled acetate washout from the brain appears to reflect CO2 exhaustion and oxygen consumption in astrocytes. We measured the time-radioactivity curves of benzyl [1-(14)C]acetate ([1-(14)C]BA), a lipophilic probe of [1-(14)C]acetate, and compared it with that of benzyl [2-(14)C]acetate ([2-(14)C]BA) in rat brains. The highest brain uptake was observed immediately after injecting either [1-(14)C]BA or [2-(14)C]BA, and both subsequently disappeared from the brain in a single-exponential manner. Estimated [1-(14)C]BA washout rates in the cerebral cortex and cerebellum were higher than those of [2-(14)C]BA. These results suggested that [1-(14)C]BA could be a useful probe for estimating the astrocytic oxidative metabolism. The [1-(14)C]BA washout rate in the cerebral cortex of immature rats was lower than that of mature rats. An autoradiographic study showed that the washout rates of [1-(14)C]BA from the rat brains of a lithium-pilocarpine-induced status epilepticus model were not significantly different from the values in control rat brains except for the medial septal nucleus. These results implied that the enhancement of amino acid turnover rate rather than astrocytic oxidative metabolism was increased in status epilepticus. © The Author(s) 2015.

  12. The spectra of WC9 stars: evolution and dust formation

    NASA Astrophysics Data System (ADS)

    Williams, P. M.; Crowther, P. A.; van der Hucht, K. A.

    2015-05-01

    We present analyses of new optical spectra of three WC9 stars, WR 88, WR 92 and WR 103 to test the suggestion that they exemplify an evolutionary sequence amongst the WC9 stars. The spectrum of WR 88 shows conspicuous lines of N III and N IV, leading to classification as a transitional WN8o/WC9 star. The three stars show a sequence of increasing O II and O III line strengths, confirming and extending earlier studies. The spectra were analysed using CMFGEN models, finding greater abundances of oxygen and carbon in WR 103 than in WR 92 and, especially, in WR 88. Of the three stars, only WR 103 makes circumstellar dust. We suggest that oxygen itself does not enhance this process but that it is its higher carbon abundance that allows WR 103 to make dust.

  13. THE PREVALENCE AND IMPACT OF WOLF–RAYET STARS IN EMERGING MASSIVE STAR CLUSTERS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sokal, Kimberly R.; Johnson, Kelsey E.; Indebetouw, Rémy

    We investigate Wolf–Rayet (WR) stars as a source of feedback contributing to the removal of natal material in the early evolution of massive star clusters. Despite previous work suggesting that massive star clusters clear out their natal material before the massive stars evolve into the WR phase, WR stars have been detected in several emerging massive star clusters. These detections suggest that the timescale for clusters to emerge can be at least as long as the time required to produce WR stars (a few million years), and could also indicate that WR stars may be providing the tipping point inmore » the combined feedback processes that drive a massive star cluster to emerge. We explore the potential overlap between the emerging phase and the WR phase with an observational survey to search for WR stars in emerging massive star clusters hosting WR stars. We select candidate emerging massive star clusters from known radio continuum sources with thermal emission and obtain optical spectra with the 4 m Mayall Telescope at Kitt Peak National Observatory and the 6.5 m MMT.{sup 4} We identify 21 sources with significantly detected WR signatures, which we term “emerging WR clusters.” WR features are detected in ∼50% of the radio-selected sample, and thus we find that WR stars are commonly present in currently emerging massive star clusters. The observed extinctions and ages suggest that clusters without WR detections remain embedded for longer periods of time, and may indicate that WR stars can aid, and therefore accelerate, the emergence process.« less

  14. An X-ray Study of a Massive Star and its Wind

    NASA Astrophysics Data System (ADS)

    Maeda, Yoshitomo; Sugawara, Yasuharu; Tsuboi, Yohko; Hamaguchi, Kenji

    2010-10-01

    WR 140 is one of the best known examples of a Wolf-Rayet stars. We executed the Suzaku X-ray observations at four different epochs around periastron passage in Jan. 2009 to understand the W-R stellar wind as well as the wind-wind collision shocks. The column density at periastron is about 30 times higher than that at pre-periastron, which can be explained as self-absorption by the Wolf-Rayet wind. The spectra are dominated by a line and continuum emission from a optically thin-thermal plasma. The strong Ne-K lines are evidence that the thermal plasma is shock-heated W-R wind materials by the interaction with the wind from the companion O star. We present the parameters of the wind, such as a mass-loss rate, which were calculated with the absorption and line emission in the spectra.

  15. Survey of selected pathogens and blood parameters of northern yellowstone elk: Wolf sanitation effect implications

    USGS Publications Warehouse

    Barber-Meyer, S. M.; White, P.J.; Mech, L.D.

    2007-01-01

    The restoration or conservation of predators could reduce seroprevalences of certain diseases in prey if predation selectively removes animals exhibiting clinical signs. We assessed disease seroprevalences and blood parameters of 115 adult female elk (Cervus elaphus) wintering on the northern range of Yellowstone National Park [YNP] during 2000-2005 and compared them to data collected prior to wolf (Canis lupus) restoration (WR) in 1995 and to two other herds in Montana to assess this prediction. Blood parameters were generally within two standard deviations of the means observed in other Montana herds (Gravelly-Snowcrest [GS] and Garnet Mountain [GM]), but Yellowstone elk had higher seroprevalences of parainfluenza-3 virus (95% CI YNP = 61.1-78.6, GS = 30.3-46.5) and bovine-virus-diarrhea virus type 1 (95% CI YNP = 15.9-31.9, GM = 0). In comparisons between pre-wolf restoration [pre-WR] (i.e., prior to 1995) seroprevalences with those post-wolf restoration [post-WR] in Yellowstone, we found lower seroprevalences for some disease-causing agents post-wolf restoration (e.g., bovine-virus-diarrhea virus type-1 [95% CI pre-WR = 73.1-86.3, post-WR = 15.9-31.9] and bovine-respiratory syncytial virus [95% CI pre-WR = 70.0-83.8, post-WR = 0]), but similar (e.g., Brucella abortus [95% CI pre-WR = 0-4.45, post-WR = 0-4.74] and epizootic hemorrhagic disease virus [95% CI pre-WR = 0, post-WR = 0]) or higher for others (e.g., Anaplasma marginale [95% CI pre-WR = 0, post-WR = 18.5-38.7] and Leptospira spp. [95% CI pre-WR = 0.5-6.5, post-WR = 9.5-23.5]). Though we did not detect an overall strong predation effect through reduced disease seroprevalence using retrospective comparisons with sparse data, our reference values will facilitate future assessments of this issue.

  16. SAFL Baffle retrofit for suspended sediment removal in storm sewer sumps.

    PubMed

    Howard, Adam; Mohseni, Omid; Gulliver, John; Stefan, Heinz

    2011-11-15

    Standard sumps (manholes) provide a location for pipe junctions and maintenance access in stormwater drainage systems. Standard sumps can also remove sand and silt particles from stormwater, but have a high propensity for washout of the collected sediment. With appropriate maintenance these sumps may qualify as a stormwater best management practice (BMP) device for the removal of suspended sediment from stormwater runoff. To decrease the maintenance frequency and prevent standard sumps from becoming a source of suspended sediment under high flow conditions, a porous baffle, named the SAFL Baffle, has been designed and tested as a retrofit to the sump. Multiple configurations with varying percent open area and different angles of attack were evaluated in scale models. An optimum configuration was then constructed at the prototype scale and evaluated for both removal efficiency and washout. Results obtained with the retrofit indicate that with the right baffle dimensions and porosity, sediment washout from the sump at high flow rates can be almost eliminated, and removal efficiency can be significantly increased at low flow rates. Removal efficiency and washout functions have been developed for standard sumps retrofitted with the SAFL Baffle. The results of this research provide a new, versatile stormwater treatment device and implemented new washout and removal efficiency testing procedures that will improve research and development of stormwater treatment devices. Copyright © 2011 Elsevier Ltd. All rights reserved.

  17. Methane Hydrate Concentrations at GC955 and WR313 Drilling Sites in the Gulf of Mexico Determined from Seismic Prestack Waveform Inversion

    NASA Astrophysics Data System (ADS)

    Fortin, W.; Goldberg, D.; Küçük, H. M.

    2016-12-01

    Gas hydrates are naturally occurring compounds, which, at a molecular scale, are lattice structures of ice embedded with various gas molecules in the lattice voids. Volumetric estimates of associated hydrocarbons vary greatly due to the difficulty in remotely estimating hydrate concentrations in marine sediments but embedded hydrocarbon stores are thought to represent a significant portion of global deposits. The unstable nature of methane hydrates has been linked to submarine landslides and the subsequent release of large quantities of methane can accelerate global climate change. Understanding the details of gas hydrate systems is important for potential economic production and assessing natural hazards risks. Seismic reflection techniques are uniquely capable of detecting gas hydrates. Often, hydrate layers appear as bottom simulating reflectors (BSRs); however, BSRs are not present everywhere gas hydrates are known to occur. Using recently reprocessed prestack time migrated data and prestack waveform inversion (PWI) techniques, we produce velocity models at high vertical and horizontal resolution in order to investigate the presence of gas hydrates in the Gulf of Mexico. Coupling our PWI results with known velocity-property relationships and data from nearby well controls, we determine the viability of recently collected high-resolution seismic data and outline small-scale heterogeneities at GC955 and WR313. We outline where PWI techniques are capable of identifying gas hydrates in seismic reflection data where BSRs are not present.

  18. Eclipses and dust formation by WC9 type Wolf-Rayet stars

    NASA Astrophysics Data System (ADS)

    Williams, P. M.

    2014-12-01

    Visual photometry of 16 WC8-9 dust-making Wolf-Rayet (WR) stars during 2001-2009 was extracted from the All-Sky Automated Survey All Star Catalogue (ASAS-3) to search for eclipses attributable to extinction by dust formed in clumps in our line of sight. Data for a comparable number of dust-free WC6-9 stars were also examined to help characterize the data set. Frequent eclipses were observed from WR 104, and several from WR 106, extending the 1994-2001 studies by Kato et al., but not supporting their phasing the variations in WR 104 with its `pinwheel' rotation period. Only four other stars showed eclipses, WR 50 (one of the dust-free stars), WR 69, WR 95 and WR 117, and there may have been an eclipse by WR 121, which had shown two eclipses in the past. No dust eclipses were shown by the `historic' eclipsers WR 103 and WR 113. The atmospheric eclipses of the latter were observed but the suggestion by David-Uraz et al. that dust may be partly responsible for these is not supported. Despite its frequent eclipses, there is no evidence in the infrared images of WR 104 for dust made in its eclipses, demonstrating that any dust formed in this process is not a significant contributor to its circumstellar dust cloud and suggesting that the same applies to the other stars showing fewer eclipses.

  19. Exercise Thresholds on Trial: Are They Really Equivalent?

    PubMed

    Caen, Kevin; Vermeire, Kobe; Bourgois, Jan G; Boone, Jan

    2018-06-01

    The interchangeable use of whole-body exercise thresholds and breakpoints (BP) in the local oxygenation response, as measured via near-infrared spectroscopy, has recently been questioned in scientific literature. Therefore, the present study aimed to longitudinally investigate the interrelationship of four commonly used exercise thresholds: critical power (CP), the respiratory compensation point (RCP), and BP in muscle (m[HHb]BP) and brain (c[O2Hb]BP) oxygenation. Nine male participants (21.8 ± 1.2 yr) completed 6 wk of cycling interval training. Before and after this intervention period, subjects performed a ramp incremental exercise protocol to determine RCP, m[HHb]BP, and c[O2Hb]BP and four constant work rate (WR) tests to calculate CP. WR associated with CP, RCP, m[HHB]BP, and c[O2Hb]BP increased by 7.7% ± 4.2%, 13.6% ± 9.0%, 9.8% ± 5.7%, and 11.3% ± 11.1%, respectively. CP was lower (pre: 260 ± 32 W, post: 280 ± 41 W; P < 0.05) than the WR associated with RCP (pre: 281 ± 28 W, post: 318 ± 36 W) and c[O2Hb]BP (pre: 283 ± 36 W, post: 313 ± 32 W) which occurred concomitantly (P = 0.683). M[HHb]BP occurred at the highest WR and differed from all others (pre: 313 ± 23 W, post: 344 ± 32 W; P < 0.05). Training-induced WR differences (ΔWR) did not contrast between thresholds, and initial parameter differences were not affected by the intervention (P = 0.253). Thresholds were partly correlated before (R = 0.67-0.85, P < 0.05) and after (R = 0.83-0.96, P < 0.05) training, but ΔWR values were not associated (P > 0.05). Results of the present study strongly question true equivalence of CP, RCP, m[HHb]BP, and c[O2Hb]BP during ramp incremental exercise. Therefore, these exercise thresholds should not be used interchangeably.

  20. Astronomy in Denver: Spectropolarimetric Observations of 5 Wolf-Rayet Binary Stars with SALT/RSS

    NASA Astrophysics Data System (ADS)

    Fullard, Andrew; Ansary, Zyed; Azancot Luchtan, Daniel; Gallegos, Hunter; Luepker, Martin; Hoffman, Jennifer L.; Nordsieck, Kenneth H.; SALT observation team

    2018-06-01

    Mass loss from massive stars is an important yet poorly understood factor in shaping their evolution. Wolf-Rayet (WR) stars are of particular interest due to their stellar winds, which create large regions of circumstellar material (CSM). They are also supernova and possible gamma-ray burst (GRB) progenitors. Like other massive stars, WR stars often occur in binaries, where interaction can affect their mass loss rates and provide the rapid rotation thought to be required for GRB production. The diagnostic tool of spectropolarimetry, along with the potentially eclipsing nature of a binary system, helps us to better characterize the CSM created by the stars’ colliding winds. Thus, we can determine mass loss rates and infer rapid rotation. We present spectropolarimetric results for five WR+O eclipsing binary systems, obtained with the Robert Stobie Spectrograph at the South African Large Telescope, between April 2017 and April 2018. The data allow us to map both continuum and emission line polarization variations with phase, which constrains where different CSM components scatter light in the systems. We discuss our initial findings and interpretations of the polarimetric variability in each binary system, and compare the systems.

  1. Validation Studies for Early Learning and Care Quality Rating and Improvement Systems: A Review of the Literature. Working Paper WR-1051-DOEL

    ERIC Educational Resources Information Center

    Karoly, Lynn A.

    2014-01-01

    Care Quality Rating and Improvement Systems (QRISs) have advanced and matured, a number of states and localities have undertaken evaluations to validate the systems. Such efforts stem from the desire to ensure that the system is designed and operating in the ways envisioned when the system was established. Given that a central component in a QRIS…

  2. Influence of the number of players and the relative pitch area per player on heart rate and physical demands in youth soccer.

    PubMed

    Castellano, Julen; Puente, Asier; Echeazarra, Ibon; Casamichana, David

    2015-06-01

    The aim of this study was to analyze the influence of different large-sided games on the physical and physiological variables in under-13 soccer players. The effects on heart rate (HR) and physical demands of different number of players (NP) (7, 9, and 11) together with the relative pitch area (RPA) (100, 200, and 300 m) during two 12-minute repetitions were analyzed in this study. The variables analyzed were mean, maximum and different intensity zones of HR; total distance (TD); work:rest ratio (W:R); player load (PL); 5 absolute and 3 relative speed categories. The results support the hypothesis that a change in pitch dimensions affects locomotor activity more than the NP does but also refute the hypothesis that the change in the NP has a greater effect on HR. To be more specific, an increase in the RPA per player (300/200/100 m2) was associated with higher values of the following variables: TD (2,250-2,314/2,003-2,148/1,766-1,845 m), W:R (0.5-0.6/0.4-0.5/0.3 arbitrary unit [AU]), PL (271-306/246-285/229-267 AU), %HRmean (85-88/85-89/81-83%), %HRmax (95-100/97-100/95-98%), and affected the percentage of time spent in both absolute (above 8 km·h(-1)) and relative speed (above 40% Vmax) categories (p ≤ 0.05, effect size: 0.31-0.85). These results may help youth soccer coaches to plan the progressive introduction of large-sided games so that task demands are adapted to the physiological and physical development of participants.

  3. Relationships among condition indices, feeding and growth of walleye in Lake Erie

    USGS Publications Warehouse

    Hartman, K.J.; Margraf, F.J.

    2006-01-01

    Condition indices are often used as surrogates of fish health, growth, and feeding and to compare ecological well-being among fish populations. In an effort to identify easily measured indices, growth and food consumption were compared with gonadal-somatic index, liver-somatic index (LSI), fat-somatic index and relative weight (Wr) for ages 1-3 walleye, Sander vitreus (Mitchill), in Lake Erie from 1986 to 1988. The LSI and Wr were significantly correlated with growth rate or food consumption, but correlations were too small to be considered biologically meaningful. Furthermore, no consistent relationships between condition indices and growth or consumption were found among combinations of fish age and season. None of the indices are considered reliable surrogates for more laborious estimates of growth and food consumption for Lake Erie walleye. Significant relationships between Wr and relative abundance of key prey species warrant further investigation. ?? 2006 Blackwell Publishing Ltd.

  4. Effect of the dilution rate on microbial competition: r-strategist can win over k-strategist at low substrate concentration.

    PubMed

    Winkler, Mari-K H; Boets, Pieter; Hahne, Birk; Goethals, Peter; Volcke, Eveline I P

    2017-01-01

    The conditions present in both in vitro and in vivo ecosystems determine the microbial population harbouring it. One commonly accepted theory is that a species with a high substrate affinity and low growth rate (k-strategist) will win the competition against a second species with a lower substrate affinity and higher growth rate (r-strategist) if both species are subjected to low substrate concentrations. In this study two nitrite oxidizing bacteria (NOB), Nitrospira defluvii (k-strategist) and Nitrobacter vulgaris (r-strategist), were cultivated in a continuous reactor systems. The minimal hydraulic retention time (HRT) required for maintaining the slower growing Nitrospira was first determined. A reactor containing Nitrobacter was set to the same HRT and Nitrospira was injected to evaluate the effect of the dilution rate on the competition between both species. By following the microbial population dynamics with qPCR analysis, it was shown that not only the substrate affinity drives the competition between k- and r-strategists but also the dilution rate. Experimental data and numerical simulations both revealed that the washout of Nitrobacter was significantly delayed at dilution rates close to the μmax of Nitrospira. The competition could be even reverted towards Nitrobacter (r-strategist) despite of low nitrite concentrations and dilution rates lower than the μmax of Nitrospira.

  5. Uncovering multiple Wolf-Rayet star clusters and the ionized ISM in Mrk 178: the closest metal-poor Wolf-Rayet H II galaxy

    NASA Astrophysics Data System (ADS)

    Kehrig, C.; Pérez-Montero, E.; Vílchez, J. M.; Brinchmann, J.; Kunth, D.; García-Benito, R.; Crowther, P. A.; Hernández-Fernández, J.; Durret, F.; Contini, T.; Fernández-Martín, A.; James, B. L.

    2013-07-01

    New integral field spectroscopy (IFS) has been obtained for the nearby metal-poor Wolf-Rayet (WR) galaxy Mrk 178 to examine the spatial correlation between its WR stars and the neighbouring ionized interstellar medium (ISM). The strength of the broad WR features and its low metallicity make Mrk 178 an intriguing object. We have detected the blue and red WR bumps in different locations across the field of view (˜300 pc × 230 pc) in Mrk 178. The study of the WR content has been extended, for the first time, beyond its brightest star-forming knot uncovering new WR star clusters. Using Large/Small Magellanic Cloud-template WR stars, we empirically estimate a minimum of ˜20 WR stars within the region sampled. Maps of the spatial distribution of the emission lines and of the physical-chemical properties of the ionized ISM have been created and analysed. Here, we refine the statistical methodology by Pérez-Montero et al. (2011) to probe the presence of variations in the ISM properties. An error-weighted mean of 12+log(O/H) = 7.72 ± 0.01 is taken as the representative oxygen abundance for Mrk 178. A localized N and He enrichment, spatially correlated with WR stars, is suggested by this analysis. Nebular He II λ4686 emission is shown to be spatially extended reaching well beyond the location of the WR stars. This spatial offset between WRs and He II emission can be explained based on the mechanical energy input into the ISM by the WR star winds, and does not rule out WR stars as the He II ionization source. We study systematic aperture effects on the detection and measurement of the WR features, using Sloan Digital Sky Survey spectra combined with the power of IFS. In this regard, the importance of targeting low metallicity nearby systems is discussed.

  6. Prediction of Chemoresistance in Women Undergoing Neo-Adjuvant Chemotherapy for Locally Advanced Breast Cancer: Volumetric Analysis of First-Order Textural Features Extracted from Multiparametric MRI.

    PubMed

    Panzeri, M M; Losio, C; Della Corte, A; Venturini, E; Ambrosi, A; Panizza, P; De Cobelli, F

    2018-01-01

    To assess correlations between volumetric first-order texture parameters on baseline MRI and pathological response after neoadjuvant chemotherapy (NAC) for locally advanced breast cancer (BC). 69 patients with locally advanced BC candidate to neoadjuvant chemotherapy underwent MRI within 4 weeks from the start of therapeutic regimen. T2, DWI, and DCE sequences were analyzed and maps were generated for Apparent Diffusion Coefficient (ADC), T2 signal intensity, and the following dynamic parameters: k -trans, peak enhancement, area under curve (AUC), time to maximal enhancement (TME), wash-in rate, and washout rate. Volumetric analysis of these parameters was performed, yielding a histogram analysis including first-order texture kinetics (percentiles, maximum value, minimum value, range, standard deviation, mean, median, mode, skewness, and kurtosis). Finally, correlations between these values and response to NAC (evaluated on the surgical specimen according to RECIST 1.1 criteria) were assessed. Out of 69 tumors, 33 (47.8%) achieved complete pathological response, 26 (37.7%) partial response, and 10 (14.5%) no response. Higher levels of AUCmax ( p value = 0.0338), AUCrange ( p value = 0.0311), and TME 75 ( p value = 0.0452) and lower levels of washout 10 ( p value = 0.0417), washout 20 ( p value = 0.0138), washout 25 ( p value = 0.0114), and washout 30 ( p value = 0.05) were predictive of noncomplete response. Histogram-derived texture analysis of MRI images allows finding quantitative parameters predictive of nonresponse to NAC in women affected by locally advanced BC.

  7. EMG and oxygen uptake responses during slow and fast ramp exercise in humans.

    PubMed

    Scheuermann, Barry W; Tripse McConnell, Joyce H; Barstow, Thomas J

    2002-01-01

    This study examined the relationship between muscle recruitment patterns using surface electromyography (EMG) and the excess O(2) uptake (Ex.V(O(2))) that accompanies slow (SR, 8 W min(-1)) but not fast (FR, 64 W min(-1)) ramp increases in work rate (WR) during exercise on a cycle ergometer. Nine subjects (2 females) participated in this study (25 +/- 2 years, +/- S.E.M.). EMG was obtained from the vastus lateralis and medialis and analysed in the time (root mean square, RMS) and frequency (median power frequency, MDPF) domain. Results for each muscle were averaged to provide an overall response and expressed relative to a maximal voluntary contraction (%MVC). Delta.V(O(2))/DeltaWR was calculated for exercise below (S(1)) and above (S(2)) the lactate threshold (LT) using linear regression. The increase in RMS relative to the increase in WR for exercise below the LT (DeltaRMS/DeltaWR-S(1)) was determined using linear regression. Due to non-linearities in RMS above the LT, DeltaRMS/DeltaWR-S(2) is reported as the difference in RMS (DeltaRMS) and the difference in WR (DeltaWR) at end-exercise and the LT. SR was associated with a higher (P < 0.05) Delta.V(O(2))/DeltaWR (S(1), 9.3 +/- 0.3 ml min(-1) W(-1); S(2), 12.5 +/- 0.6 ml min(-1) W(-1)) than FR (S(1), 8.5 +/- 0.4 ml min(-1) W(-1); S(2), 7.9 +/- 0.4 ml min(-1) W(-1)) but a similar DeltaRMS/DeltaWR-S(1) (SR, 0.11 +/- 0.01% W(-1); FR, 0.10 +/- 0.01 % W(-1)). Ex.V(O(2)) was greater (P < 0.05) in SR (3.6 +/- 0.7 l) than FR (-0.7 +/- 0.4 l) but was not associated with a difference in either DeltaRMS/DeltaWR-S(2) (SR, 0.14 +/- 0.01% W(-1); FR, 15 +/- 0.02 % W(-1)) or MDPF (SR, 2.6 +/- 5.9 %; FR, -15.4 +/- 4.5 %). The close matching between power output and RMS during SR and FR suggests that the Ex.V(O(2)) of heavy exercise is not associated with the recruitment of additional motor units since Ex.V(O(2)) was observed during SR only. Compared to the progressive decrease in MDPF observed during FR, the MDPF remained

  8. Correlates of diuretic renography in experimental hydronephrosis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kekomaeki, M.R.; Rikalainen, H.; Ruotsalainen, P.

    1989-02-01

    We studied the correlations between diuretic renographs and kidney function in experimental hydronephrosis in rabbits. Features of furosemide-stimulated /sup 99m/Tc-diethylenetriamine-pentaacetic acid renographs were compared to the growth rate, thirst test and endogenous creatinine clearance rate in a chronic solitary-kidney animal model. Intravenous pyelograms, done four weeks after laparotomy, left nephrectomy, bladder resection and constriction of the right pyeloureteric junction, showed signs of obstruction in all the 12 animals of the experimental group. An absent tracer washout after intravenous furosemide, found in five animals, was associated with retarded growth, isosthenuria and an abnormal creatinine clearance. In all of the other sevenmore » animals, a distinct tracer washout after intravenous furosemide was accompanied with a normal growth rate and creatinine clearance. However, no one of these seven animals had a normal ability to retain water and concentrate urine in the thirst test. We conclude that, in this experimental model, a furosemide-induced tracer washout from the kidney pelvis cannot be taken as a proof of the absence of any upper urinary tract obstruction.« less

  9. Business Planning Model Programmer’s Guide

    DTIC Science & Technology

    1993-12-01

    BPMREPI.PRG 847 temnpupgrade BPMOPEN.PRG 163 te - da -org BPMWHA2.PRG 1949 te tot BPMWHA2.PRG 1912 tgzzoggle BPMWHA2.PRG 349 tlbr UTILITY.PRG 921 toggle...closewindowIdispcapital get-totals disp capital. openwindow disp capital pad disp capital showeditinsg disp__capital tlbr disp capital wr-arr disp capital wr-dulsUdisp_...showeditnisg disp__contract tlbr disp contract wr -arrIdisp_ contract wr -duls disp contract wr uls disp__contract wrjyears disp expense closewindow

  10. On Surface Losses in Direct Metal Laser Sintering Printed Millimeter and Submillimeter Waveguides

    NASA Astrophysics Data System (ADS)

    Holmberg, Max; Dancila, Dragos; Rydberg, Anders; Hjörvarsson, Björgvin; Jansson, Ulf; Marattukalam, Jithin James; Johansson, Niklas; Andersson, Joakim

    2018-02-01

    Different lengths of WR3 (220-330 GHz) and WR10 (75-110 GHz) waveguides are fabricated through direct metal laser sintering (DMLS). The losses in these waveguides are measured and modelled using the Huray surface roughness model. The losses in WR3 are around 0.3 dB/mm and in WR10 0.05 dB/mm. The Huray equation model is accounting relatively good for the attenuation in the WR10 waveguide but deviates more in the WR3 waveguide. The model is compared to finite element simulations of the losses assuming an approximate surface structure similar to the resulting one from the DMLS process.

  11. A new survey of nebulae around Galactic Wolf-Rayet stars in the northern sky

    NASA Technical Reports Server (NTRS)

    Miller, Grant J.; Chu, You-Hua

    1993-01-01

    Interference filter CCD images have been obtained in H-alpha and forbidden O III 5007 A for 62 Wolf-Rayet (W-R) stars, representing a complete survey of nebulae around Galactic W-R stars in the northern sky. We find probable new ring nebulae around W-R stars number 113, 116 and 132, and possible new ring nebulae around W-R stars number 133 and 153. All survey images showing nebulosities around W-R stars are presented in this paper. New physical information is derived from the improved images of known ring nebulae. The absence of ring nebulae around most W-R stars is discussed.

  12. On Surface Losses in Direct Metal Laser Sintering Printed Millimeter and Submillimeter Waveguides

    NASA Astrophysics Data System (ADS)

    Holmberg, Max; Dancila, Dragos; Rydberg, Anders; Hjörvarsson, Björgvin; Jansson, Ulf; Marattukalam, Jithin James; Johansson, Niklas; Andersson, Joakim

    2018-06-01

    Different lengths of WR3 (220-330 GHz) and WR10 (75-110 GHz) waveguides are fabricated through direct metal laser sintering (DMLS). The losses in these waveguides are measured and modelled using the Huray surface roughness model. The losses in WR3 are around 0.3 dB/mm and in WR10 0.05 dB/mm. The Huray equation model is accounting relatively good for the attenuation in the WR10 waveguide but deviates more in the WR3 waveguide. The model is compared to finite element simulations of the losses assuming an approximate surface structure similar to the resulting one from the DMLS process.

  13. Peritoneal clearances in hypertensive CAPD patients after oral administration of clonidine, enalapril, and nifedipine.

    PubMed

    Favazza, A; Motanaro, D; Messa, P; Antonucci, F; Gropuzzo, M; Mioni, G

    1992-01-01

    The authors investigated whether the reduction of arterial pressure, induced by the oral administration of clonidine (CLO), enalapril (EN), and nifedipine (NIF), has any effect on peritoneal transport rates. The study was performed in nine hypertensive patients undergoing continuous ambulatory peritoneal dialysis (CAPD). The patients were submitted to administration of CLO, EN, and NIF, each in randomized succession for two weeks, after withdrawal of any hypotensive therapy for eight days (washout period). The nine patients underwent a four-hour dwell exchange using a 2.27 g/dL glucose two-liter bag after washout and after each hypotensive period. The following parameters were analyzed: mean arterial pressure (MAP), performed in the sitting position; net ultrafiltration; effluent/initial dialysate glucose ratio (GL D/Do); peritoneal clearance of K, BUN, creatinine (Cr), phosphate, beta-2 microglobulin (beta 2), total proteins, and the ratio between beta 2 and Cr clearance. Moreover, residual renal Cr and beta 2 clearances were analyzed. The three drugs significantly reduced MAP at a similar rate. The peritoneal transport parameters after CLO were similar to the results in the washout period. On the contrary, after EN and NIF therapy, Cr and beta 2 clearances were significantly increased, and GL D/Do decreased in comparison to the washout period. The other peritoneal transport parameters after EN and NIF were similar to the washout period. Residual renal Cr and beta 2 clearances after the three drugs were similar to those in the washout. these data suggest that after two weeks of therapy with EN and NIF, glucose, Cr, and beta 2 peritoneal transports are influenced by these hypotensive drugs irrespective of the effect on the arterial pressure.(ABSTRACT TRUNCATED AT 250 WORDS)

  14. Walk-Rally Support System Using Two-Dimensional Codes and Mobile Phones

    ERIC Educational Resources Information Center

    Miyagawa, Tetsuya; Yamagishi, Yoshio; Mizuno, Shun

    2013-01-01

    "Walk Rally" (WR), an orienteering-like recreation game, is common, especially in Japan. Numerous trials to combine WR with educational activities are being carried out by some educators. However, participants are always at the risk of straying and subjected to various accidents during the WR. We developed a WR support system based on…

  15. Gamma-ray burst progenitors and the population of rotating Wolf-Rayet stars.

    PubMed

    Vink, Jorick S

    2013-06-13

    In our quest for gamma-ray burst (GRB) progenitors, it is relevant to consider the progenitor evolution of normal supernovae (SNe). This is largely dominated by mass loss. We discuss the mass-loss rate for very massive stars up to 300M⊙. These objects are in close proximity to the Eddington Γ limit. We describe the new concept of the transitional mass-loss rate, enabling us to calibrate wind mass loss. This allows us to consider the occurrence of pair-instability SNe in the local Universe. We also discuss luminous blue variables and their link to luminous SNe. Finally, we address the polarization properties of Wolf-Rayet (WR) stars, measuring their wind asphericities. We argue to have found a group of rotating WR stars that fulfil the required criteria to make long-duration GRBs.

  16. Washout of water-soluble vitamins and of homocysteine during haemodialysis: effect of high-flux and low-flux dialyser membranes.

    PubMed

    Heinz, Judith; Domröse, Ute; Westphal, Sabine; Luley, Claus; Neumann, Klaus H; Dierkes, Jutta

    2008-10-01

    Vitamin deficiencies are common in patients with end-stage renal disease (ESRD) owing to dietary restrictions, drug-nutrient interactions, changes in metabolism, and vitamin losses during dialysis. The present study investigated the levels of serum and red blood cell (RBC) folate, plasma pyridoxal-5'-phosphate (PLP), serum cobalamin, blood thiamine, blood riboflavin, and plasma homocysteine (tHcy) before and after haemodialysis treatment. Vitamin and tHcy blood concentrations were measured in 30 patients with ESRD before and after dialysis session either with low-flux (n = 15) or high-flux (n = 15) dialysers. After the dialysis procedure, significantly lower concentrations of serum folate (37%), plasma PLP (35%), blood thiamine (6%) and blood riboflavin (7%) were observed. No significant changes were found for serum cobalamin or for RBC folate. There were no differences in the washout of water-soluble vitamins between treatments with low-flux and high-flux membranes. Furthermore, a 41% lower concentration in tHcy was observed. The percentage decrease in tHcy was significantly greater in the patients treated with high-flux dialysers (48% vs 37%; P < 0.01). The percentage change during dialysis was significantly inversely related to the molecular weight of the vitamins measured (r =-0.867, P < 0.01). This study showed significantly lower blood or serum levels of various water-soluble vitamins after dialysis, independently of the dialyser membrane. The monitoring of the vitamin status is essential in patients treated with high-flux dialysers as well as in patients treated with low-flux dialysers.

  17. The effect of vacuum devices on penile hemodynamics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Katz, P.G.; Haden, H.T.; Mulligan, T.

    1990-01-01

    External vacuum devices are being used increasingly for the management of erectile dysfunction. There is limited information regarding the effect of vacuum devices on penile blood flow and potential for ischemic penile injury. The penile xenon washout rate was measured before and after application of 2 vacuum systems in 15 subjects. Compared to flaccid state measurements the xenon washout rate did not change significantly with the Synergist Erection System but it was significantly reduced with the Osbon ErecAid System. However, the degree and duration of decrease in penile blood flow that may result in ischemic changes are unknown.

  18. Comparing Digital Flood Insurance Rate Maps (DFIRMs) to Interferometric Synthetic Aperture Radar (IFSAR) Products

    DTIC Science & Technology

    2000-09-01

    specifications and procedures call for the use of Digital Orthophoto Quarter Quadrangles (DOQs) produced by the USGS to be the default base map if...egm96.html (14 September 2000). USGS. “Digital Orthophoto Quadrangles”, http://www-wmc.wr.usgs.gov/doq (7 November 2000). United States Naval...Technologies Inc. Global Terrain Metadata File (DEM) File Creation date: Wednesday, June 02, 1999 Tile Identifier #: GT1N36W075H8V1.bil Project Area

  19. Prestack Waveform Inversion and Well Log Examination at GC955 and WR313 in the Gulf of Mexico for Estimation of Methane Hydrate Concentrations

    NASA Astrophysics Data System (ADS)

    Fortin, W.; Goldberg, D.; Kucuk, H. M.

    2017-12-01

    Gas hydrates are naturally occurring compounds, which, at a molecular scale, are lattice structures of ice embedded with various gas molecules in the lattice voids. Volumetric estimates of associated hydrocarbons vary greatly due to the difficulty in remotely estimating hydrate concentrations in marine sediments but embedded hydrocarbon stores are thought to represent a significant portion of global deposits. Inherent hydrate instabilities obscure our understanding of and complicates processes related to resource extraction and hydrate response to disturbances in the local environment. Understanding the spatial extent and variability of hydrate deposits have important implications for potential economic production, climate change, and assessing natural hazards risks. Seismic reflection techniques are capable of determining the extent of gas hydrate deposits, often through the observation of bottom simulating reflectors (BSRs). However, BSRs are not present everywhere gas hydrates exist. Using high resolution prestack time migrated seismic data and prestack waveform inversion (PWI) we produce highly resolved velocity models and compare them to co-located well logs. Coupling our PWI results with velocity-porosity relationships and nearby well control, we map hydrate properties at GC955 and WR313. Integrating small scale heterogeneities and variations along the velocity model with in-situ measurements, we develop a workflow aimed to quantify hydrate concentrations observed in seismic data over large areas in great detail regardless of the existence of a BSR.

  20. A search for ejecta nebulae around Wolf-Rayet stars using the SHS Hα survey

    NASA Astrophysics Data System (ADS)

    Stock, D. J.; Barlow, M. J.

    2010-12-01

    Recent large-scale Galactic plane Hα surveys allow a re-examination of the environs of Wolf-Rayet (WR) stars for the presence of a circumstellar nebula. Using the morphologies of WR nebulae known to be composed of stellar ejecta as a guide, we constructed ejecta nebula criteria similar to those of Chu and searched for likely WR ejecta nebulae in the Southern Hα Survey (SHS). A new WR ejecta nebula around WR 8 is found and its morphology is discussed. The fraction of WR stars with ejecta-type nebulae is roughly consistent between the Milky Way (MW) and Large Magellanic Cloud (LMC) at around 5-6 per cent, with the MW sample dominated by nitrogen-rich WR central stars (WN type) and the LMC stars having a higher proportion of carbon-rich WR central stars (WC type). We compare our results with those of previous surveys, including those of Marston and Miller & Chu, and find broad consistency. We investigate several trends in the sample: most of the clear examples of ejecta nebulae have WNh central stars, and very few ejecta nebulae have binary central stars. Finally, the possibly unique evolutionary status of the nebula around the binary star WR 71 is explored.

  1. Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates.

    PubMed

    Vandeputte, Doris; Falony, Gwen; Vieira-Silva, Sara; Tito, Raul Y; Joossens, Marie; Raes, Jeroen

    2016-01-01

    The assessment of potentially confounding factors affecting colon microbiota composition is essential to the identification of robust microbiome based disease markers. Here, we investigate the link between gut microbiota variation and stool consistency using Bristol Stool Scale classification, which reflects faecal water content and activity, and is considered a proxy for intestinal colon transit time. Through 16S rDNA Illumina profiling of faecal samples of 53 healthy women, we evaluated associations between microbiome richness, Bacteroidetes:Firmicutes ratio, enterotypes, and genus abundance with self-reported, Bristol Stool Scale-based stool consistency. Each sample's microbiota growth potential was calculated to test whether transit time acts as a selective force on gut bacterial growth rates. Stool consistency strongly correlates with all known major microbiome markers. It is negatively correlated with species richness, positively associated to the Bacteroidetes:Firmicutes ratio, and linked to Akkermansia and Methanobrevibacter abundance. Enterotypes are distinctly distributed over the BSS-scores. Based on the correlations between microbiota growth potential and stool consistency scores within both enterotypes, we hypothesise that accelerated transit contributes to colon ecosystem differentiation. While shorter transit times can be linked to increased abundance of fast growing species in Ruminococcaceae-Bacteroides samples, hinting to a washout avoidance strategy of faster replication, this trend is absent in Prevotella-enterotyped individuals. Within this enterotype adherence to host tissue therefore appears to be a more likely bacterial strategy to cope with washout. The strength of the associations between stool consistency and species richness, enterotypes and community composition emphasises the crucial importance of stool consistency assessment in gut metagenome-wide association studies. Published by the BMJ Publishing Group Limited. For permission to

  2. Prediction of Chemoresistance in Women Undergoing Neo-Adjuvant Chemotherapy for Locally Advanced Breast Cancer: Volumetric Analysis of First-Order Textural Features Extracted from Multiparametric MRI

    PubMed Central

    Losio, C.; Della Corte, A.; Venturini, E.; Ambrosi, A.; Panizza, P.; De Cobelli, F.

    2018-01-01

    Purpose To assess correlations between volumetric first-order texture parameters on baseline MRI and pathological response after neoadjuvant chemotherapy (NAC) for locally advanced breast cancer (BC). Materials and Methods 69 patients with locally advanced BC candidate to neoadjuvant chemotherapy underwent MRI within 4 weeks from the start of therapeutic regimen. T2, DWI, and DCE sequences were analyzed and maps were generated for Apparent Diffusion Coefficient (ADC), T2 signal intensity, and the following dynamic parameters: k-trans, peak enhancement, area under curve (AUC), time to maximal enhancement (TME), wash-in rate, and washout rate. Volumetric analysis of these parameters was performed, yielding a histogram analysis including first-order texture kinetics (percentiles, maximum value, minimum value, range, standard deviation, mean, median, mode, skewness, and kurtosis). Finally, correlations between these values and response to NAC (evaluated on the surgical specimen according to RECIST 1.1 criteria) were assessed. Results Out of 69 tumors, 33 (47.8%) achieved complete pathological response, 26 (37.7%) partial response, and 10 (14.5%) no response. Higher levels of AUCmax (p value = 0.0338), AUCrange (p value = 0.0311), and TME75 (p value = 0.0452) and lower levels of washout10 (p value = 0.0417), washout20 (p value = 0.0138), washout25 (p value = 0.0114), and washout30 (p value = 0.05) were predictive of noncomplete response. Conclusion Histogram-derived texture analysis of MRI images allows finding quantitative parameters predictive of nonresponse to NAC in women affected by locally advanced BC. PMID:29853811

  3. Implications of the Low Binary Black Hole Aligned Spins Observed by LIGO

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hotokezaka, Kenta; Piran, Tsvi

    We explore the implications of the low-spin components along the orbital axis observed in an Advanced LIGO O1 run on binary black hole (BBH) merger scenarios in which the merging BBHs have evolved from field binaries. The coalescence time determines the initial orbital separation of BBHs. This, in turn, determines whether the stars are synchronized before collapse, and hence determines their projected spins. Short coalescence times imply synchronization and large spins. Among known stellar objects, Wolf–Rayet (WR) stars seem to be the only progenitors consistent with the low aligned spins observed in LIGO’s O1, provided that the orbital axis maintainsmore » its direction during the collapse. We calculate the spin distribution of BBH mergers in the local universe, and its redshift evolution for WR progenitors. Assuming that the BBH formation rate peaks around a redshift of ∼2–3, we show that BBH mergers in the local universe are dominated by low-spin events. The high-spin population starts to dominate at a redshift of ∼0.5–1.5. WR stars are also progenitors of long gamma-ray bursts that take place at a comparable rate to BBH mergers. We discuss the possible connection between the two phenomena. Additionally, we show that hypothetical Population III star progenitors are also possible. Although WR and Population III progenitors are consistent with the current data, both models predict a non-vanishing fraction of high positive values of the BBHs’ aligned spin. If those are not detected within the coming LIGO/Virgo runs, it will be unlikely that the observed BBHs formed via field binaries.« less

  4. 8-Aminoquinolines from Walter Reed Army Institute for Research for treatment and prophylaxis of Pneumocystis pneumonia in rat models.

    PubMed Central

    Bartlett, M S; Queener, S F; Tidwell, R R; Milhous, W K; Berman, J D; Ellis, W Y; Smith, J W

    1991-01-01

    Three 8-aminoquinolines from the Walter Reed Army Institute for Research (WRAIR), WR6026, WR238605, and WR242511, strongly inhibited Pneumocystis carinii growth in vitro at 1 microgram/ml. This activity was similar to that of primaquine. In rat therapy models, the WRAIR compounds affected Pneumocystis pneumonia at doses as low as 0.25 mg/kg (WR242511) or 0.5 mg/kg (WR6026 and WR238605). At these doses, primaquine alone was ineffective as therapy. In a rat prophylaxis model, all three WRAIR 8-aminoquinolines were extremely effective at daily doses of 0.57 mg/kg, showing activity greater than that of primaquine at this dosage and comparable to that of trimethoprim-sulfamethoxazole at 50/250 mg/kg. PMID:2024961

  5. Assessment of inflow and washout of indocyanine green in the adult human brain by monitoring of diffuse reflectance at large source-detector separation

    NASA Astrophysics Data System (ADS)

    Liebert, Adam; Sawosz, Piotr; Milej, Daniel; Kacprzak, Michał; Weigl, Wojciech; Botwicz, Marcin; MaCzewska, Joanna; Fronczewska, Katarzyna; Mayzner-Zawadzka, Ewa; Królicki, Leszek; Maniewski, Roman

    2011-04-01

    Recently, it was shown in measurements carried out on humans that time-resolved near-infrared reflectometry and fluorescence spectroscopy may allow for discrimination of information originating directly from the brain avoiding influence of contaminating signals related to the perfusion of extracerebral tissues. We report on continuation of these studies, showing that the near-infrared light can be detected noninvasively on the surface of the tissue at large interoptode distance. A multichannel time-resolved optical monitoring system was constructed for measurements of diffuse reflectance in optically turbid medium at very large source-detector separation up to 9 cm. The instrument was applied during intravenous injection of indocyanine green and the distributions of times of flight of photons were successfully acquired showing inflow and washout of the dye in the tissue. Time courses of the statistical moments of distributions of times of flight of photons are presented and compared to the results obtained simultaneously at shorter source-detector separations (3, 4, and 5 cm). We show in a series of experiments carried out on physical phantom and healthy volunteers that the time-resolved data acquisition in combination with very large source-detector separation may allow one to improve depth selectivity of perfusion assessment in the brain.

  6. Stabilization of glucocorticoid receptors in isolated rat hepatocytes by radioprotectants

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Karle, J.M.; Ridder, W.E.; Wright, N.

    1986-05-01

    Previous work has shown that glucocorticoid receptors in rat liver homogenate can be stabilized by the addition of MoO/sub 4/ plus the sulfhydryl-containing compounds dithiothreitol and WR 1065. The latter is the dephosphorylated, principal metabolite of the radioprotectant WR 2721 (or S-2-(3-aminopropylamino)ethanesphosphorothioic acid). The current work results from applying this knowledge to intact rat hepatocytes. Cells were isolated by collagenase perfusion and incubated in supplemented minimum essential medium at 37/sup 0/C with various concentrations of WR 2721, WR 1065, or vehicle. Samples of these cell suspensions were analyzed at various times for steroid binding capacity by incubating homogenates (27,000 xmore » g supernates) with 50 nM /sup 3/H-triamcinolone acetonide in the presence or absence of excess unlabelled dexamethasone. Concentrations of 10 mM WR 2721 provided marked preservation of the binding capacity (>85% of the initial value at 5 hours) compared to control at <20% by 2 hours. WR 2721 at 1 mM preserved >60% of the binding capacity. WR 1065 at 10 mM provided no such protection. This is consistent with the observation that WR 1065 does not pass cell membranes. The authors propose that supplying reducing equivalents to intracellular components such as the glucocorticoid receptor may be one mechanism of the radioprotection afforded by WR 2721.« less

  7. Infrared Photometric Study of Wolf–Rayet Galaxies

    NASA Astrophysics Data System (ADS)

    Chen, P. S.; Yang, X. H.; Liu, J. Y.; Shan, H. G.

    2018-01-01

    We collected observational data on 781 Wolf–Rayet (WR) galaxies from the literature to photometrically study their infrared properties measured by the 2MASS, WISE, IRAS, AKARI, and Herschel missions. It is found that in the 1–5 μm range the radiations of WR galaxies are dominated by the free–free emissions from the stellar winds and the circumstellar dust from the late-type stars in the host galaxy. In the 5–22 μm range, the radiation of WR galaxies is dominated by the free–free emissions and the synchrotron radiation from the central active galactic nucleus (AGN; but not always present). In the 22–140 μm range, the radiations of WR galaxies are dominated by the free–free emissions and the star formation/starburst activities. In the 250–500 μm range, the radiation of WR galaxies is dominated by the free–free emissions. In addition, the comparison with the non-WR galaxies is made. It is shown that some star formation WR galaxies have redder near-infrared colors than non-WR star-forming galaxies probably due to the gas emission in the near-infrared. In the 2–5 μm region WR galaxies have redder colors due to the thermal emission from circumstellar dust of late-type stars and the enhanced gas emission. In the 5–22 μm region, both WR galaxies and non-WR galaxies have similar behavior, indicative of having similar free–free emission as the dominant radiation. In the 25–140 μm region, both types of galaxies also have similar behavior, indicative of having free–free emission from the stellar winds or the thermal radiation from the starburst/star formation as the dominant radiation.

  8. Wolf-Rayet stars in the Small Magellanic Cloud as testbed for massive star evolution

    NASA Astrophysics Data System (ADS)

    Schootemeijer, A.; Langer, N.

    2018-03-01

    Context. The majority of the Wolf-Rayet (WR) stars represent the stripped cores of evolved massive stars who lost most of their hydrogen envelope. Wind stripping in single stars is expected to be inefficient in producing WR stars in metal-poor environments such as the Small Magellanic Cloud (SMC). While binary interaction can also produce WR stars at low metallicity, it is puzzling that the fraction of WR binaries appears to be about 40%, independent of the metallicity. Aim. We aim to use the recently determined physical properties of the twelve known SMC WR stars to explore their possible formation channels through comparisons with stellar models. Methods: We used the MESA stellar evolution code to construct two grids of stellar models with SMC metallicity. One of these consists of models of rapidly rotating single stars, which evolve in part or completely chemically homogeneously. In a second grid, we analyzed core helium burning stellar models assuming constant hydrogen and helium gradients in their envelopes. Results: We find that chemically homogeneous evolution is not able to account for the majority of the WR stars in the SMC. However, in particular the apparently single WR star SMC AB12, and the double WR system SMC AB5 (HD 5980) appear consistent with this channel. We further find a dichotomy in the envelope hydrogen gradients required to explain the observed temperatures of the SMC WR stars. Shallow gradients are found for the WR stars with O star companions, while much steeper hydrogen gradients are required to understand the group of hot apparently single WR stars. Conclusions: The derived shallow hydrogen gradients in the WR component of the WR+O star binaries are consistent with predictions from binary models where mass transfer occurs early, in agreement with their binary properties. Since the hydrogen profiles in evolutionary models of massive stars become steeper with time after the main sequence, we conclude that most of the hot (Teff > 60 k

  9. Combined effect of coffee ingestion and repeated bouts of low-intensity exercise on fat oxidation.

    PubMed

    Kurobe, Kazumichi; Nakao, Saori; Nishiwaki, Masato; Matsumoto, Naoyuki

    2017-03-01

    We investigated the effect of the combination of coffee ingestion and repeated bouts of low-intensity exercise on fat oxidation. Subjects were seven young, healthy male adults. They performed four trials: a single 30-min bout of exercise following ingestion of plain hot water (WS) or coffee (CS); a trial with three 10-min bouts of exercise separated by 10-min periods of rest following ingestion of plain hot water (WR) or coffee (CR). The coffee contained 5 mg kg -1 of caffeine. All trials were performed on a cycle ergometer at 40% maximal oxygen uptake for each subject an hour after beverage ingestion. Oxygen uptake in the CS and CR trials was higher compared with the WS and WR trials at 90 min after exercise (P<0·05). Respiratory exchange ratio (RER) in the CS and CR trials was decreased during the whole recovery period compared with baseline (P<0·05), whereas no significant decreases were observed in either the WS or WR trials. Moreover, RER was significantly lower at 30 min after exercise in the CR trial than in either the WS or WR trials (P<0·05 each). Similarly, it is notable that fat oxidation rate in the CR trial was significantly higher at 30 min after exercise compared to that in the WS and WR trials (P<0·05). These results suggest that the combination of coffee intake and repeated bouts of low-intensity exercise enhances fat oxidation in the period after exercise. © 2015 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.

  10. First survey of Wolf-Rayet star populations over the full extension of nearby galaxies observed with CALIFA

    NASA Astrophysics Data System (ADS)

    Miralles-Caballero, D.; Díaz, A. I.; López-Sánchez, Á. R.; Rosales-Ortega, F. F.; Monreal-Ibero, A.; Pérez-Montero, E.; Kehrig, C.; García-Benito, R.; Sánchez, S. F.; Walcher, C. J.; Galbany, L.; Iglesias-Páramo, J.; Vílchez, J. M.; González Delgado, R. M.; van de Ven, G.; Barrera-Ballesteros, J.; Lyubenova, M.; Meidt, S.; Falcon-Barroso, J.; Mast, D.; Mendoza, M. A.; Califa Collaboration

    2016-08-01

    The search of extragalactic regions with conspicuous presence of Wolf-Rayet (WR) stars outside the Local Group is challenging task owing to the difficulty in detecting their faint spectral features. In this exploratory work, we develop a methodology to perform an automated search of WR signatures through a pixel-by-pixel analysis of integral field spectroscopy (IFS) data belonging to the Calar Alto Legacy Integral Field Area survey, CALIFA. This procedure has been applied to a sample of nearby galaxies spanning a wide range of physical, morphological, and environmental properties. This technique allowed us to build the first catalogue of regions rich in WR stars with spatially resolved information, and enabled us to study the properties of these complexes in a two-dimensional (2D) context. The detection technique is based on the identification of the blue WR bump (around He IIλ4686 Å, mainly associated with nitrogen-rich WR stars; WN) and the red WR bump (around C ivλ5808 Å, mainly associated with carbon-rich WR stars; WC) using a pixel-by-pixel analysis that maximizes the number of independent regions within a given galaxy. We identified 44 WR-rich regions with blue bumps distributed in 25 out of a total of 558 galaxies. The red WR bump was identified only in 5 of those regions. Most of the WR regions are located within one effective radius from the galaxy centre, and around one-third are located within ~1 kpc or less from the centre. We found that the majority of the galaxies hosting WR populations in our sample are involved in some kind of interaction process. Half of the host galaxies share some properties with gamma-ray burst (GRB) hosts where WR stars, such as potential candidates to the progenitors of GRBs, are found. We also compared the WR properties derived from the CALIFA data with stellar population synthesis models, and confirm that simple star models are generally not able to reproduce the observations. We conclude that other effects, such as

  11. Attention networks in adolescent anorexia nervosa.

    PubMed

    Weinbach, Noam; Sher, Helene; Lock, James D; Henik, Avishai

    2018-03-01

    Anorexia nervosa (AN) usually develops during adolescence when considerable structural and functional brain changes are taking place. Neurocognitive inefficiencies have been consistently found in adults with enduring AN and were suggested to play a role in maintaining the disorder. However, such findings are inconsistent in children and adolescents with AN. The current study conducted a comprehensive assessment of attention networks in adolescents with AN who were not severely underweight during the study using an approach that permits disentangling independent components of attention. Twenty partially weight-restored adolescents with AN (AN-WR) and 24 healthy adolescents performed the Attention Network Test which assesses the efficiency of three main attention networks-executive control, orienting, and alerting. The results revealed abnormal function in the executive control network among adolescents with AN-WR. Specifically, adolescents with AN-WR demonstrated superior ability to suppress attention to task-irrelevant information while focusing on a central task. Moreover, the alerting network modulated this ability. No difference was found between the groups in the speed of orienting attention, but reorienting attention to a target resulted in higher error rates in the AN-WR group. The findings suggest that adolescents with AN have attentional abnormalities that cannot be explained by a state of starvation. These attentional dysregulations may underlie clinical phenotypes of the disorder such as increased attention of details.

  12. Revealing the nebular properties and Wolf-Rayet population of IC10 with Gemini/GMOS

    NASA Astrophysics Data System (ADS)

    Tehrani, Katie; Crowther, Paul A.; Archer, I.

    2017-12-01

    We present a deep imaging and spectroscopic survey of the Local Group irregular galaxy IC10 using Gemini North and GMOS to unveil its global Wolf-Rayet (WR) population. We obtain a star formation rate (SFR) of 0.045 ± 0.023 M⊙ yr-1, for IC10 from the nebular H α luminosity, which is comparable to the Small Magellanic Cloud. We also present a revised nebular oxygen abundance of log(O/H) + 12 = 8.40 ± 0.04, comparable to the LMC. It has previously been suggested that for IC10 to follow the WR subtype-metallicity dependance seen in other Local Group galaxies, a large WN population awaits discovery. Our search revealed three new WN stars, and six candidates awaiting confirmation, providing little evidence to support this claim. The new global WR star total of 29 stars is consistent with the Large Magellanic Cloud population when scaled to the reduced SFR of IC10. For spectroscopically confirmed WR stars, the WC/WN ratio is lowered to 1.0; however, including all potential candidates, and assuming those unconfirmed to be WN stars, would reduce the ratio to ∼0.7. We attribute the high WC/WN ratio to the high star formation surface density of IC10 relative to the Magellanic Clouds, which enhances the frequency of high-mass stars capable of producing WC stars.

  13. Preventing a Washout.

    ERIC Educational Resources Information Center

    Poindexter, Dave

    1996-01-01

    Offers ideas for locating a roof leak. Discusses why many leaks originate in the roof's base flashings and the importance of knowing the roof's material makeup. Advocates keeping a roof-leak history and gives advice on performing inspections to check for leaks. Discusses how to find small holes in roofs. (RJM)

  14. Determination/Validation of Technologies for Treatment/Recycle of Contaminated Sludges: Phase 1 - Site/Sludge Characterization and Laboratory Testing

    DTIC Science & Technology

    1998-08-01

    b. WR-ALC IWTP Plant #2 ........................... 35 2. Analysis of WR-ALC IWTP Streams and Sludges ................. 36 a. RCRA Metal Removal at WR...ECONOMIC ANALYSIS OF MOS-LLX AND USE OF A STOICHIO- METRIC AMOUNT OF FERROUS SULFATE FOR CrvI REDUCTION AT IWTP PLANT #2 AT WR-ALC...per day ICP or ICAP Inductively coupled Argon Plasma Elemental Analysis Technique IWTP Industrial Waste Water Treatment Plant LIX Liquid Ion Exchange

  15. Influence of thyroid gland status on the thyroglobulin cutoff level in washout fluid from cervical lymph nodes of patients with recurrent/metastatic papillary thyroid cancer.

    PubMed

    Lee, Jun Ho; Lee, Hyun Chul; Yi, Ha Woo; Kim, Bong Kyun; Bae, Soo Youn; Lee, Se Kyung; Choe, Jun-Ho; Kim, Jung-Han; Kim, Jee Soo

    2016-04-01

    The influence of serum thyroglobulin (Tg) and thyroidectomy status on Tg in fine-needle aspiration cytology (FNAC) washout fluid is unclear. A total of 282 lymph nodes were prospectively subjected to FNAC, fine-needle aspiration (FNA)-Tg measurement, and frozen and permanent biopsies. We evaluated the diagnostic performance of several predetermined FNA-Tg cutoff values for recurrence/metastasis in lymph nodes according to thyroidectomy status. The diagnostic performance of FNA-Tg varied according to thyroidectomy status. The optimized cutoff value of FNA-Tg was 2.2 ng/mL. However, among FNAC-negative lymph nodes, the FNA-Tg cutoff value of 0.9 ng/mL showed better diagnostic performance in patients with a thyroid gland. An FNA-Tg/serum-Tg cutoff ratio of 1 showed the best diagnostic performance in patients without a thyroid gland. Applying the optimal cutoff values of FNA-Tg according to thyroid gland status and serum Tg level facilitates the diagnostic evaluation of neck lymph node recurrences/metastases in patients with papillary thyroid carcinoma (PTC). © 2015 Wiley Periodicals, Inc. Head Neck 38: E1705-E1712, 2016. © 2015 Wiley Periodicals, Inc.

  16. Work-related mild-moderate traumatic brain injury and the construction industry.

    PubMed

    Liu, Margaret; Wei, Wenli; Fergenbaum, Jennifer; Comper, Paul; Colantonio, Angela

    2011-01-01

    Consequences of traumatic brain injury underscore the need to study high-risk groups. Few studies have investigated work-related traumatic brain injuries (WrTBIs) in the construction industry. To examine WrTBIs in Ontario for the construction industry compared to other industries. A retrospective study of individuals who sustained a WrTBI and had a clinical assessment as an outpatient at a hospital-based referral centre. Data were collected for a number of factors including demographic, injury and occupation and were analyzed according to the Person-Environment-Occupation (PEO) model. 435 individuals who sustained a WrTBI. There were 19.1% in the construction industry, 80.9% in other industries. Compared to other industries, individuals in the construction industry were more likely to be male, to not have attained post-secondary education, and experience multiple traumas. WrTBIs in the construction industry were commonly due to elevated work. The construction occupations involved included skilled workers and general labourers, and compared to other industries, WrTBIs occurred most often for those employed for a short duration in the construction industry. Construction industry workers experience serious WrTBIs that are amenable to prevention. Use of the PEO model increased our understanding of WrTBIs in the construction industry.

  17. An X-ray spectral study of colliding wind binaries

    NASA Astrophysics Data System (ADS)

    Sugawara, Yasuharu; Maeda, Yoshitomo; Tsuboi, Yohko

    2012-03-01

    We present results of spectral studies of two Wolf-Rayet colliding wind binaries (WR 140 and WR 30a), using the data obtained by the Suzaku and XMM-Newton satellites. WR 140 is one of the best known examples of a Wolf-Rayet star. We executed the Suzaku X-ray observations at four different epochs around periastron passage in Jan. 2009 to understand the W-R stellar wind as well as the wind-wind collision shocks. We detected hard X-ray excess in the HXD band (> 10 keV) for the first time from a W-R binary. The emission measure of the dominant, high temperature component is not inversely proportional to the distance between the two stars. WR 30a is the rare WO-type W-R binary. We executed XMM-Newton observations and detected X-ray emission for the first time. The broad-band spectrum was well-fitted with double-absorption model. The hard X-ray emission was heavily absorbed. This can be interpreted that the hard X-ray emitting plasma exist near WO star.

  18. Hepatic Phospholipidosis Is Associated with Altered Hepatobiliary Function as Assessed by Gadoxetate Dynamic Contrast-enhanced Magnetic Resonance Imaging.

    PubMed

    Lenhard, Stephen C; Lev, Mally; Webster, Lindsey O; Peterson, Richard A; Goulbourne, Christopher N; Miller, Richard T; Jucker, Beat M

    2016-01-01

    To determine if amiodarone induces hepatic phospholipidosis (PLD) sufficient to detect changes in hepatobiliary transporter function as assessed by gadoxetate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), rats were orally dosed with vehicle (1% methyl cellulose) or amiodarone (300 mg/kg/day) for 7 consecutive days. Gadoxetate DCE-MRI occurred at baseline, day 7, and following a 2-week washout of amiodarone. At day 7, the gadoxetate washout rate was significantly decreased compared to the vehicle group. Blood chemistry analysis revealed no significant changes in liver enzymes (alanine aminotransferase [ALT]/aspartate aminotransferase [AST]/alkaline phosphatase [ALP]), bilirubin, or bile acids between vehicle or amiodarone groups. Hepatic PLD was confirmed in all rats treated with amiodarone at day 7 by transmission electron microscopy. Following the 2-week washout, there was no ultrastructural evidence of hepatic PLD in rats and the gadoxetate washout rate returned to baseline levels. This is the first study to show the application of gadoxetate DCE-MRI to detect hepatobiliary functional changes associated with PLD and offer a potential new technique with clinical utility in patients suspected of having PLD. These results also suggest PLD itself has functional consequences on hepatobiliary function in the absence of biomarkers of toxicity, given the cause/effect relationship between PLD and function has not been fully established. © The Author(s) 2015.

  19. A deep survey for Galactic Wolf-Rayet stars. I - Motivation, search technique, and first results

    NASA Technical Reports Server (NTRS)

    Shara, Michael M.; Smith, Lindsey F.; Potter, Michael; Moffat, Anthony F. J.

    1991-01-01

    Results are presented from a survey of large areas of the southern Milky Way for Wolf-Rayet (WR) stars to 17-18th magnitude, carried out using direct narrowband and broadband Schmidt plates. Thirteen new WR stars were detected in an about 40-deg-sq region in Carina, where 24 WR stars were already known; the new stars were found to be significantly redder, fainter, and farther away than the known stars. Of the new WR stars, 11 are of subtype WN, and two are WC, compared to the 17 WN and seven WC stars among the previously known WR stars in the same area.

  20. Chemotherapy of Rodent Malaria.

    DTIC Science & Technology

    1981-09-01

    floxacrine analogue WR* (BK 02771) which remained fully effective against P.y.nigeriensis challenge seven days after treatment and was still partially...In particular we note that the Mannich base WR 194965 is highly active sc against the N strain and the moderately chloroquine resistant RC strain. The...this line. Floxacrine and the two floxacrine analogues WR* (BK02771) and WR* (BK 02780) have been compared and, whilst both analogues are markedj

  1. Factors responsible for the patchy distribution of natural soil water repellency in Mediterranean semiarid forest

    NASA Astrophysics Data System (ADS)

    Lozano, E.; Jiménez-Pinilla, P.; Mataix-Solera, J.; González-Pérez, J. A.; García-Orenes, F.; Torres, M. P.; Arcenegui, V.; Mataix-Beneyto, J.

    2012-04-01

    Soil water repellency (WR) is commonly observed in forest areas showing wettable and water repellent patches with high spatial variability. This has important hydrological implications; in semiarid areas where water supply is limited, even slight WR may play an important role in infiltration patterns and distribution of water into the soil (Mataix-Solera et al., 2007). It has been proposed that the origin of WR is the release of organic compounds from different plants species and sources (due to waxes and other organic substances in their tissues; Doerr et al., 1998). However, the relationship between WR and plants may not always be a direct one: a group of fungi (mainly mycorrhizal fungi) and microorganisms could be also responsible for WR. The aim of this research is to study the relationships between WR in soils under different plant cover with selected soil properties and the quantity of fungi and their exudates. The study area is located in Southeast Spain, "Sierra de la Taja" near Pinoso (Alicante)), with a semiarid Mediterranean climate (Pm=260mm). Samples were taken in September 2011, when WR is normally strongest after summer drought. Soil samples were collected from the first 2.5cm of the mineral A horizon at microsites beneath each of the four most representative species (Pinus halepensis, Rosmarinus officinalis, Quercus. rotundifolia and Cistus albidus; n=15 per specie) and 5 samples from bare soil with no influence of any species. Different soil parameters were analyzed; water content, soil organic mater content (SOM), pH, WR, easily extractable glomalin (EEG), total mycelium and extractable lipids. The occurrence of WR was higher under P. halepensis (87% of samples) and Q. rotundifolia (60% of samples). Positive significant correlations were found between WR and SOM content for all species, with the best correlations for Pinus and Quercus (r=0.855**, r= 0.934** respectively). In addition, negative significant correlations were found between WR and p

  2. Seafloor Tectonic Fault Fabric and the Evolution of the Walvis Ridge-Rio Grande Rise Hot Spot Twins in the South Atlantic

    NASA Astrophysics Data System (ADS)

    Sager, W. W.; Engfer, D.; Thoram, S.; Koppers, A. A. P.; Class, C.

    2015-12-01

    Walvis Ridge (WR) and Rio Grande Rise (RGR) are Cretaceous-Cenozoic large igneous provinces (LIPs) formed by the Tristan-Gough hot spot interacting with the Mid-Atlantic Ridge (MAR). Although hot spot-ridge interaction has long been considered a primary factor controlling WR-RGR morphology, details are fuzzy owing to sparse geophysical data. We examined tectonic fabric revealed in satellite altimetry-derived gravity data to infer details about RGR-WR evolution. Plate tectonic reconstructions indicate that the main RGR plateau and large N-S plateau in the eastern WR erupted at the same point at ~90 Ma. Over the next ~8 Myr, these conjunct LIPs formed a "V" shape with a basin in between. Curved fracture zones within the basin imply the two LIPs formed around a microplate. The prominent rift in the middle of RGR formed nearly perpendicular to the RGR-WR intersection, suggesting an extensional microplate boundary. Hot spot eruptions continued at the MAR, emplacing the eastern WR and two main RGR plateaus until ~60 Ma. During this period, the N-S trending Eastern Rio Grande Rise (ERGR) was erupted along the MAR. Both the ERGR and WR formed bathymetric lineaments parallel to seafloor fault fabric and were likely connected. This resulted in WR seamounts with a "tadpole" shape, the head being small to medium seamounts on the WR track and the tails being low, spreading-fabric-parallel ridges extending up to ~150 km northward. Similar, small seamounts are found in the contemporaneous ERGR. Another critical observation is that the WR-RGR formed at a large crustal discontinuity (~700 km at anomaly C33, ~84 Ma) at one or more fracture zone offsets. By late Cenozoic time (anomaly C5, ~10 Ma), the offset was reduced by half while several new fracture zones formed at the junction between RGR and WR. This implies a connection between ridge reorganization and RGR-WR volcanism that may have resulted from the fracture zones becoming oblique to the spreading direction as Euler poles

  3. Postmenopausal estrogen therapy modulates nocturnal nonlinear heart rate dynamics.

    PubMed

    Virtanen, Irina; Ekholm, Eeva; Polo-Kantola, Päivi; Hiekkanen, Heikki; Huikuri, Heikki

    2008-01-01

    To study the effects of postmenopausal estrogen therapy (ET) on nocturnal nonlinear heart rate variability (HRV). In this prospective, randomized, double-blind, placebo-controlled study, 71 healthy hysterectomized postmenopausal women received either transdermal estradiol or placebo for 3 months. After a washout period of 1 month, the treatments were reversed. Sleep studies were performed after both treatment periods. One steady-state epoch per night of the awake state, stage 2 (light) non-rapid eye movement (REM) sleep, stage 3-4 (deep) non-REM sleep, also known as slow-wave sleep, and REM sleep was extracted. From the electrocardiogram, nonlinear HRV was analyzed as the fractal scaling exponents alpha1 and alpha2, approximate entropy (ApEn), and the Poincaré plot variability coefficients SD1 and SD2. These were correlated to ET use in both different sleep stages and averaged across all sleep stages. During ET, the nocturnal ApEn decreased from 0.80 +/- 0.01 to 0.74 +/- 0.02 (P < 0.05), the most marked reduction occurring during slow-wave sleep (from 0.77 +/- 0.05 to 0.63 +/- 0.06, P < 0.05). In addition, SD2 decreased in slow-wave sleep and REM sleep during ET (P < 0.05 for both). In light non-REM sleep, alpha1 slightly increased during ET (P < 0.05). ET has a slightly but distinctively attenuating effect on some nocturnal nonlinear measures of HRV, especially on complexity of heart rate dynamics. This implies that ET may have potentially deleterious effects on cardiovascular health during sleep.

  4. A SYSTEMATIC SEARCH FOR COROTATING INTERACTION REGIONS IN APPARENTLY SINGLE GALACTIC WOLF-RAYET STARS. II. A GLOBAL VIEW OF THE WIND VARIABILITY

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chene, A.-N.; St-Louis, N., E-mail: achene@astro-udec.cl, E-mail: stlouis@astro.umontreal.ca

    This study is the second part of a survey searching for large-scale spectroscopic variability in apparently single Wolf-Rayet (WR) stars. In a previous paper (Paper I), we described and characterized the spectroscopic variability level of 25 WR stars observable from the northern hemisphere and found 3 new candidates presenting large-scale wind variability, potentially originating from large-scale structures named corotating interaction regions (CIRs). In this second paper, we discuss an additional 39 stars observable from the southern hemisphere. For each star in our sample, we obtained 4-5 high-resolution spectra with a signal-to-noise ratio of {approx}100 and determined its variability level usingmore » the approach described in Paper I. In total, 10 new stars are found to show large-scale spectral variability of which 7 present CIR-type changes (WR 8, WR 44, WR55, WR 58, WR 61, WR 63, WR 100). Of the remaining stars, 20 were found to show small-amplitude changes and 9 were found to show no spectral variability as far as can be concluded from the data on hand. Also, we discuss the spectroscopic variability level of all single galactic WR stars that are brighter than v {approx} 12.5, and some WR stars with 12.5 < v {<=} 13.5, i.e., all the stars presented in our two papers and four more stars for which spectra have already been published in the literature. We find that 23/68 stars (33.8%) present large-scale variability, but only 12/54 stars ({approx}22.1%) are potentially of CIR type. Also, we find that 31/68 stars (45.6%) only show small-scale variability, most likely due to clumping in the wind. Finally, no spectral variability is detected based on the data on hand for 14/68 (20.6%) stars. Interestingly, the variability with the highest amplitude also has the widest mean velocity dispersion.« less

  5. Antihypercholesterolemic and Antioxidative Potential of an Extract of the Plant, Piper betle, and Its Active Constituent, Eugenol, in Triton WR-1339-Induced Hypercholesterolemia in Experimental Rats.

    PubMed

    Venkadeswaran, Karuppasamy; Muralidharan, Arumugam Ramachandran; Annadurai, Thangaraj; Ruban, Vasanthakumar Vasantha; Sundararajan, Mahalingam; Anandhi, Ramalingam; Thomas, Philip A; Geraldine, Pitchairaj

    2014-01-01

    Hypercholesterolemia is a dominant risk factor for atherosclerosis and cardiovascular diseases. In the present study, the putative antihypercholesterolemic and antioxidative properties of an ethanolic extract of Piper betle and of its active constituent, eugenol, were evaluated in experimental hypercholesterolemia induced by a single intraperitoneal injection of Triton WR-1339 (300 mg/kg b.wt) in Wistar rats. Saline-treated hypercholesterolemic rats revealed significantly higher mean blood/serum levels of glucose, total cholesterol, triglycerides, low density and very low density lipoprotein cholesterol, and of serum hepatic marker enzymes; in addition, significantly lower mean serum levels of high density lipoprotein cholesterol and significantly lower mean activities of enzymatic antioxidants and nonenzymatic antioxidants were noted in hepatic tissue samples from saline-treated hypercholesterolemic rats, compared to controls. However, in hypercholesterolemic rats receiving the Piper betle extract (500 mg/kg b.wt) or eugenol (5 mg/kg b.wt) for seven days orally, all these parameters were significantly better than those in saline-treated hypercholesterolemic rats. The hypercholesterolemia-ameliorating effect was better defined in eugenol-treated than in Piper betle extract-treated rats, being as effective as that of the standard lipid-lowering drug, lovastatin (10 mg/kg b.wt). These results suggest that eugenol, an active constituent of the Piper betle extract, possesses antihypercholesterolemic and other activities in experimental hypercholesterolemic Wistar rats.

  6. Antihypercholesterolemic and Antioxidative Potential of an Extract of the Plant, Piper betle, and Its Active Constituent, Eugenol, in Triton WR-1339-Induced Hypercholesterolemia in Experimental Rats

    PubMed Central

    Venkadeswaran, Karuppasamy; Muralidharan, Arumugam Ramachandran; Annadurai, Thangaraj; Ruban, Vasanthakumar Vasantha; Sundararajan, Mahalingam; Anandhi, Ramalingam; Thomas, Philip A.; Geraldine, Pitchairaj

    2014-01-01

    Hypercholesterolemia is a dominant risk factor for atherosclerosis and cardiovascular diseases. In the present study, the putative antihypercholesterolemic and antioxidative properties of an ethanolic extract of Piper betle and of its active constituent, eugenol, were evaluated in experimental hypercholesterolemia induced by a single intraperitoneal injection of Triton WR-1339 (300 mg/kg b.wt) in Wistar rats. Saline-treated hypercholesterolemic rats revealed significantly higher mean blood/serum levels of glucose, total cholesterol, triglycerides, low density and very low density lipoprotein cholesterol, and of serum hepatic marker enzymes; in addition, significantly lower mean serum levels of high density lipoprotein cholesterol and significantly lower mean activities of enzymatic antioxidants and nonenzymatic antioxidants were noted in hepatic tissue samples from saline-treated hypercholesterolemic rats, compared to controls. However, in hypercholesterolemic rats receiving the Piper betle extract (500 mg/kg b.wt) or eugenol (5 mg/kg b.wt) for seven days orally, all these parameters were significantly better than those in saline-treated hypercholesterolemic rats. The hypercholesterolemia-ameliorating effect was better defined in eugenol-treated than in Piper betle extract-treated rats, being as effective as that of the standard lipid-lowering drug, lovastatin (10 mg/kg b.wt). These results suggest that eugenol, an active constituent of the Piper betle extract, possesses antihypercholesterolemic and other activities in experimental hypercholesterolemic Wistar rats. PMID:24523820

  7. The first optical spectra of Wolf-Rayet stars in M101 revealed with Gemini/GMOS

    NASA Astrophysics Data System (ADS)

    Pledger, J. L.; Shara, M. M.; Wilde, M.; Crowther, P. A.; Long, K. S.; Zurek, D.; Moffat, A. F. J.

    2018-01-01

    Deep narrow-band Hubble Space Telescope (HST) imaging of the iconic spiral galaxy M101 has revealed over a thousand new Wolf-Rayet (WR) candidates. We report spectrographic confirmation of 10 He II-emission line sources hosting 15 WR stars. We find WR stars present at both sub- and super-solar metallicities with WC stars favouring more metal-rich regions compared to WN stars. We investigate the association of WR stars with H II regions using archival HST imaging and conclude that the majority of WR stars are in or associated with H II regions. Of the 10 emission lines sources, only one appears to be unassociated with a star-forming region. Our spectroscopic survey provides confidence that our narrow-band photometric candidates are in fact bona fide WR stars, which will allow us to characterize the progenitors of any core-collapse supernovae that erupt in the future in M101.

  8. Association of Commercial Rice Varieties with Weedy Rice Accessions (Oryza sativa complex) in Pulau Pinang's Rice Granary Area.

    PubMed

    Hussain, Zainudin; Man, Azmi; Othman, Ahmad Sofiman

    2011-12-01

    Weedy rice (WR) is the most significant weed in direct-seeded fields. It has morphological characteristics similar to those of cultivated rice varieties. WR is more difficult to control than other weeds. We collected WR accessions from four sites within the Pulau Pinang rice growing areas. Thirty six different accessions were collected from each site: B, the northern site; P, the central site; A, the southern site; and N, the southwestern site. Wild rice (Oryza rufipogon), which grows in the sampled areas, was also collected together with four varieties (MR84, MR185, MR211 and MR219) that have been widely planted in these areas for a long period of time. The objective of this study was to compare the morphological characteristics of the WR accessions and cultivated rice. Twenty characteristics were observed for the comparison of WR accessions and rice cultivars. Morpho-matrix analyses allowed the specimens to be grouped to two main groups (A and B), based on a 95% dissimilarity matrix. Group A was subdivided into 7 subgroups consisting of a few WR accessions, wild rice and MR211 (control), and group B was subdivided to 10 subgroups consisting of other WR accessions and the 3 other control varieties. Dendrogram analysis indicated that the morphological traits used in this study were able to differentiate among the WR accessions and the cultivars, except for rice cultivar MR211 and WRA8, which grouped together in subgroup A2. STRUCTURE program analysis indicated that all individuals were distinguishable and were divided into 18 clusters. These results suggest that some genes of the WR accessions have been influenced by commercial varieties. The information gained from this study will be useful to develop rice weed management protocols and good agricultural practices to control WR in the future.

  9. Wrist Circumference and Frame Size Percentiles in 6-17-Year-Old Turkish Children and Adolescents in Kayseri.

    PubMed

    Öztürk, Ahmet; Çiçek, Betül; Mazıcıoğlu, M Mümtaz; Zararsız, Gökmen; Kurtoğlu, Selim

    2017-12-15

    The aim of the current study was to provide wrist circumference (WrC) and body frame size (height/WrC) percentile values in Turkish children and adolescents aged 6-17 years. In this cross-sectional study, the data of "Determination of Anthropometric Measures of Turkish Children and Adolescents" (DAMTCA II) study in Kayseri/Turkey were used. A total of 4330 observations were recorded (1931 boys, 2399 girls). The WrC and frame size reference values were produced with generalized additive models for location, scale and shape. The WrC percentiles (3rd-97th) were calculated. The frame size (height/WrC) was estimated as small, medium, and large (<15 th , 15-85 th , and ≥85 th percentiles, respectively). For both genders, WrC linearly increased with age (13.0-16.8 cm for boys and 12.5-15.5 cm for girls). In boys and girls, the mean ± standard deviation of WrC is 13.00±0.89 cm and 12.48±0.93 cm (6 years) and increases to 16.83±1.16 and 15.58±0.86 cm (17 years), respectively. The WrC values in all age groups were higher in boys compared with girls. The increment in frame size from 6 to 17 years were 1.25 cm in boys and 0.85 cm in girls. WrC is a simple, easy-to-detect anthropometric index which is not subject to measurement errors. Additionally, WrC can be used both to decide about frame size and to determine metabolic risks related to obesity. We consider that this easy-to-get anthropometric index can be used both in screening procedures and clinical assessment procedure for obesity-related metabolic consequences.

  10. Chronic wheel running reduces maladaptive patterns of methamphetamine intake: regulation by attenuation of methamphetamine-induced neuronal nitric oxide synthase.

    PubMed

    Engelmann, Alexander J; Aparicio, Mark B; Kim, Airee; Sobieraj, Jeffery C; Yuan, Clara J; Grant, Yanabel; Mandyam, Chitra D

    2014-03-01

    We investigated whether prior exposure to chronic wheel running (WR) alters maladaptive patterns of excessive and escalating methamphetamine intake under extended access conditions, and intravenous methamphetamine self-administration-induced neurotoxicity. Adult rats were given access to WR or no wheel (sedentary) in their home cage for 6 weeks. A set of WR rats were injected with 5-bromo-2'-deoxyuridine (BrdU) to determine WR-induced changes in proliferation (2-h old) and survival (28-day old) of hippocampal progenitors. Another set of WR rats were withdrawn (WRw) or continued (WRc) to have access to running wheels in their home cages during self-administration days. Following self-administration [6 h/day], rats were tested on the progressive ratio (PR) schedule. Following PR, BrdU was injected to determine levels of proliferating progenitors (2-h old). WRc rats self-administered significantly less methamphetamine than sedentary rats during acquisition and escalation sessions, and demonstrated reduced motivation for methamphetamine seeking. Methamphetamine reduced daily running activity of WRc rats compared with that of pre-methamphetamine days. WRw rats self-administered significantly more methamphetamine than sedentary rats during acquisition, an effect that was not observed during escalation and PR sessions. WR-induced beneficial effects on methamphetamine self-administration were not attributable to neuroplasticity effects in the hippocampus and medial prefrontal cortex, but were attributable to WR-induced inhibition of methamphetamine-induced increases in the number of neuronal nitric oxide synthase expressing neurons and apoptosis in the nucleus accumbens shell. Our results demonstrate that WR prevents methamphetamine-induced damage to forebrain neurons to provide a beneficial effect on drug-taking behavior. Importantly, WR-induced neuroprotective effects are transient and continued WR activity is necessary to prevent compulsive methamphetamine intake.

  11. Chronic wheel running reduces maladaptive patterns of methamphetamine intake: regulation by attenuation of methamphetamine-induced neuronal nitric oxide synthase

    PubMed Central

    Engelmann, Alexander J.; Aparicio, Mark B.; Kim, Airee; Sobieraj, Jeffery C.; Yuan, Clara J.; Grant, Yanabel

    2013-01-01

    We investigated whether prior exposure to chronic wheel running (WR) alters maladaptive patterns of excessive and escalating methamphetamine intake under extended access conditions, and intravenous methamphetamine self-administration-induced neurotoxicity. Adult rats were given access to WR or no wheel (sedentary) in their home cage for 6 weeks. A set of WR rats were injected with 5-bromo-2′-deoxyuridine (BrdU) to determine WR-induced changes in proliferation (2-h old) and survival (28-day old) of hippocampal progenitors. Another set of WR rats were withdrawn (WRw) or continued (WRc) to have access to running wheels in their home cages during self-administration days. Following self-administration [6 h/day], rats were tested on the progressive ratio (PR) schedule. Following PR, BrdU was injected to determine levels of proliferating progenitors (2-h old). WRc rats self-administered significantly less methamphetamine than sedentary rats during acquisition and escalation sessions, and demonstrated reduced motivation for methamphetamine seeking. Methamphetamine reduced daily running activity of WRc rats compared with that of pre-methamphetamine days. WRw rats self-administered significantly more methamphetamine than sedentary rats during acquisition, an effect that was not observed during escalation and PR sessions. WR-induced beneficial effects on methamphetamine self-administration were not attributable to neuroplasticity effects in the hippocampus and medial prefrontal cortex, but were attributable to WR-induced inhibition of methamphetamine-induced increases in the number of neuronal nitric oxide synthase expressing neurons and apoptosis in the nucleus accumbens shell. Our results demonstrate that WR prevents methamphetamine-induced damage to forebrain neurons to provide a beneficial effect on drug-taking behavior. Importantly, WR-induced neuroprotective effects are transient and continued WR activity is necessary to prevent compulsive methamphetamine intake

  12. Blood values of adult captive cheetahs (Acinonyx jubatus) fed either supplemented beef or whole rabbit carcasses.

    PubMed

    Depauw, Sarah; Hesta, M; Whitehouse-Tedd, K; Stagegaard, J; Buyse, J; Janssens, G P J

    2012-01-01

    This study evaluated nutrient intake and relevant blood parameters of 14 captive cheetahs, randomly assigned to a meat-only diet (supplemented beef, SB) or a whole prey diet (whole rabbit, WR) for 4 weeks each. Despite a higher food intake, daily metabolizable energy intake was lower when fed WR (308 kJ BW(-1) ) compared with SB (347 kJ BW(-1) ) (P = 0.002). The ratio of protein to fat was markedly lower for WR (2.3:1) compared with SB (8.8:1), which was reflected in higher serum urea levels when fed SB (P = 0.033), and a tendency for elevated cholesterol levels when fed WR (P = 0.055). Taurine intake of cheetahs fed WR was low (0.06% on DM basis); however, analytical error during taurine analysis cannot be ruled out. Feeding WR resulted in a well-balanced mineral intake, in contrast to SB. The latter provided a low calcium:phosphorus ratio (1:2.3), thereby increasing the risk of metabolic bone disease. The high zinc content of SB (200 mg/kg DM), compared with WR (94 mg/kg DM), was reflected in higher serum zinc concentrations (P = 0.011). Feeding WR resulted in an increase in serum vitamin A (P = 0.011). Therefore, the risk of hypervitaminosis A in captive cheetahs when fed WR exclusively on a long-term basis should be evaluated. Our findings suggest that neither diet is likely to provide appropriate nutrition to captive cheetahs when fed exclusively. © 2011 Wiley Periodicals, Inc.

  13. Soil recovery across a chronosequence of restored wetlands in the Florida Everglades

    NASA Astrophysics Data System (ADS)

    Wang, Qibing; Li, Yuncong; Zhang, Min

    2015-12-01

    The restoration project in the Hole-in-the-Donut of Everglades National Park in Florida, USA is to reestablish native wetlands by complete removal of the invasive plants and the associated soil. However, there is little information available about changes in properties of the newly formed Marl soils in restored wetlands. In this study, we measured soil physicochemical properties, soil enzymatic activities, and stable isotopes of carbon (δ13C) in plants and soil organic carbon (SOC) in an undisturbed natural wetland (UNW) and three wetlands restored respectively in 1989, 1996 and 1999 (WR89, WR96 and WR99). The older restored wetlands (WR89 and WR96) are characterized by greater SOC and mineral nitrogen. The values of soil dehydrogenase and phosphatase activities in the four wetlands follow the order: UNW > WR89 > WR96 > WR99, and are consistent with changes in vegetation coverage. The principal component analysis shows that dehydrogenase and phosphatase activities are the vital variables contributing to the soil of UNW. The similar δ13C values of SOC and plants in the restored wetlands suggest the formation of SOC during restoration is mainly derived from the associated plants. These results indicate that the newly restored soils develop toward the soil in the UNW with time since restoration.

  14. Soil recovery across a chronosequence of restored wetlands in the Florida Everglades.

    PubMed

    Wang, Qibing; Li, Yuncong; Zhang, Min

    2015-12-01

    The restoration project in the Hole-in-the-Donut of Everglades National Park in Florida, USA is to reestablish native wetlands by complete removal of the invasive plants and the associated soil. However, there is little information available about changes in properties of the newly formed Marl soils in restored wetlands. In this study, we measured soil physicochemical properties, soil enzymatic activities, and stable isotopes of carbon (δ(13)C) in plants and soil organic carbon (SOC) in an undisturbed natural wetland (UNW) and three wetlands restored respectively in 1989, 1996 and 1999 (WR89, WR96 and WR99). The older restored wetlands (WR89 and WR96) are characterized by greater SOC and mineral nitrogen. The values of soil dehydrogenase and phosphatase activities in the four wetlands follow the order: UNW > WR89 > WR96 > WR99, and are consistent with changes in vegetation coverage. The principal component analysis shows that dehydrogenase and phosphatase activities are the vital variables contributing to the soil of UNW. The similar δ(13)C values of SOC and plants in the restored wetlands suggest the formation of SOC during restoration is mainly derived from the associated plants. These results indicate that the newly restored soils develop toward the soil in the UNW with time since restoration.

  15. Angiotensin II induces water absorption behavior in two species of desert anurans.

    PubMed

    Propper, C R; Johnson, W E

    1994-03-01

    The octapeptide, angiotensin II (A-II), induces drinking behavior in several vertebrate species; however, relatively little is understood about A-II-induced thirst in amphibians. Scaphiopus couchii and Bufo cognatus were dehydrated to 90% of their ad libitum weight. This level of dehydration was sufficient to induce water absorption response (WR) behavior in both species. Fully hydrated toads injected intraperitoneally with A-II exhibited a significant amount of WR behavior. The minimum effective dose for inducing WR behavior was 10 micrograms/100 g-animal for S. couchii and 100 micrograms/100 g-animal for B. cognatus. When dehydrated toads were treated with the A-II receptor antagonist, Thr8-saralasin, S. couchii, exhibited a significant increase in WR behavior, while B. cognatus did not respond behaviorally. Finally, treatment of dehydrated toads with captopril, a compound that inhibits conversion of angiotensin I to A-II, did not significantly affect WR behavior in either species. These results support other findings that A-II may be involved in WR behavior in amphibians. However, the failure of Thr2-saralasin or captopril to inhibit WR behavior in dehydrated toads suggests that the receptor mechanisms involved in thirst regulation in toads may be different from those in mammals, and the renin-angiotensin system may not be the only potential mediator of WR behavior in these species.

  16. Habitual exercise training in older adults offsets the age-related prolongation in leg vasodilator kinetics during single limb lower body exercise.

    PubMed

    Hughes, William E; Kruse, Nicholas T; Ueda, Kenichi; Casey, Darren P

    2018-06-01

    We tested the hypothesis that aging is associated with prolonged leg vasodilator kinetics and habitual exercise training in older adults improves these responses relative to untrained older adults. Additionally, we examined the relationship between contraction-induced rapid onset vasodilation (ROV) and vasodilator kinetics. Young (n=10), older untrained (n=13) and older trained (n=14) adults performed single and rhythmic knee-extension contractions at 20% and 40% work-rate maximum (WR max ). Femoral artery diameter and mean blood velocity were measured by Doppler ultrasound. Vascular conductance (VC; ml·min -1 ·mmHg-1) was calculated using blood flow (ml·min -1 ) and mean arterial pressure (mmHg). The primary outcome was the kinetic response (mean response time; MRT), modeled using an exponential model, expressed as the number of duty cycles to change 63% of the steady-state amplitude. There was no age or training related differences in VC MRT between the groups at 20% WR max . Older untrained adults exhibited prolonged VC MRT at 40% WR max relative to young (37{plus minus}16 vs. 24{plus minus}10 duty-cycles; P<0.05) and older trained adults (37{plus minus}16 vs. 23{plus minus}14 duty-cycles; P<0.05). There were no differences in VC MRT between young and older trained adults at 40% WR max (P=0.96). There were no associations between peak ROV and VC MRT at 20% or 40% WR max (r=-0.08 and 0.22; P=0.67 and 0.20, respectively) in the group as a whole. Our data suggest 1) advancing age prolongs leg vasodilator kinetics; 2) habitual exercise training in older adults offsets this age-related prolongation; and 3) contraction-induced ROV is not related to vasodilator kinetics within a group of young and older adults.

  17. Abnormal end-tidal PO(2) and PCO(2) at the anaerobic threshold correlate well with impaired exercise gas exchange in patients with left ventricular dysfunction.

    PubMed

    Kano, Hiroto; Koike, Akira; Hoshimoto-Iwamoto, Masayo; Nagayama, Osamu; Sakurada, Koji; Suzuki, Takeya; Tsuneoka, Hidekazu; Sawada, Hitoshi; Aizawa, Tadanori; Wasserman, Karlman

    2012-01-01

    The aim of the present study was to compare the end-tidal O(2) pressure (PETO(2)) to end-tidal CO(2) pressure (PETCO(2)) in cardiac patients during rest and during 2 states of exercise: at anaerobic threshold (AT) and at peak. The purpose was to see which metabolic state, PETO(2) or PETCO(2), best correlated with exercise limitation. Thirty-eight patients with left ventricular (LV) ejection fraction <40% underwent cardiopulmonary exercise testing (CPX). PETO(2) and PETCO(2) were measured during CPX, along with peak O(2) uptake (VO(2)), AT, slope of the increase in ventilation (VE) relative to the increase in CO(2) output (VCO(2)) (VE vs. VCO(2) slope), and the ratio of the increase in VO(2) to the increase in work rate (ΔVO(2)/ΔWR). Both PETO(2) and PETCO(2) measured at AT were best correlated with peakVO(2), AT, ΔVO(2)/ΔWR and VE vs. VCO(2) slope. PETO(2) at AT correlated with reduced peak VO(2) (r=-0.60), reduced AT (r=-0.52), reduced ΔVO(2)/ΔWR (r=-0.55) and increased VE vs. VCO(2) slope (r=0.74). PETCO(2) at AT correlated with reduced peak VO(2) (r=0.67), reduced AT (r=0.61), reduced ΔVO(2)/ΔWR (r=0.58) and increased VE vs. VCO(2) slope (r=-0.80). PETCO(2) and PETO(2) at AT correlated with peak VO(2), AT and ΔVO(2)/ΔWR, but best correlated with increased VE vs. VCO(2) slope. PETO(2) and PETCO(2) at AT can be used as a prime index of impaired cardiopulmonary function during exercise in patients with LV failure.

  18. A new Wolf-Rayet star and its circumstellar nebula in Aquila

    NASA Astrophysics Data System (ADS)

    Gvaramadze, V. V.; Kniazev, A. Y.; Hamann, W.-R.; Berdnikov, L. N.; Fabrika, S.; Valeev, A. F.

    2010-04-01

    We report the discovery of a new Wolf-Rayet star in Aquila via detection of its circumstellar nebula (reminiscent of ring nebulae associated with late WN stars) using the Spitzer Space Telescope archival data. Our spectroscopic follow-up of the central point source associated with the nebula showed that it is a WN7h star (we named it WR121b). We analysed the spectrum of WR121b by using the Potsdam Wolf-Rayet model atmospheres, obtaining a stellar temperature of ~=50kK. The stellar wind composition is dominated by helium with ~20 per cent of hydrogen. The stellar spectrum is highly reddened [E(B - V) = 2.85mag]. Adopting an absolute magnitude of Mv = -5.7, the star has a luminosity of logL/Lsolar = 5.75 and a mass-loss rate of 10-4.7Msolaryr-1, and resides at a distance of 6.3kpc. We searched for a possible parent cluster of WR121b and found that this star is located at ~=1° from the young star cluster embedded in the giant HII region W43 (containing a WN7+a/OB? star - WR121a). We also discovered a bow shock around the O9.5III star ALS9956, located at from the cluster. We discuss the possibility that WR121b and ALS9956 are runaway stars ejected from the cluster in W43. Based on observations collected at the German-Spanish Astronomical Center, Calar Alto, jointly operated by the Max-Planck-Institut für Astronomie Heidelberg and the Instituto de Astrofísica de Andalucía (CSIC). E-mail: vgvaram@mx.iki.rssi.ru (VVG); akniazev@saao.ac.za (AYK); wrh@astro.physik.uni-potsdam.de (WRH); berdnik@sai.msu.ru (LNB); fabrika@sao.ru (SF); azamat@sao.ru (AFV)

  19. On the optically thick winds of Wolf-Rayet stars

    NASA Astrophysics Data System (ADS)

    Gräfener, G.; Owocki, S. P.; Grassitelli, L.; Langer, N.

    2017-12-01

    Context. The classical Wolf-Rayet (WR) phase is believed to mark the end stage of the evolution of massive stars with initial masses higher than 25M⊙. Stars in this phase expose their stripped cores with the products of H- or He-burning at their surface. They develop strong, optically thick stellar winds that are important for the mechanical and chemical feedback of massive stars, and that determine whether the most massive stars end their lives as neutron stars or black holes. The winds of WR stars are currently not well understood, and their inclusion in stellar evolution models relies on uncertain empirical mass-loss relations. Aims: We investigate theoretically the mass-loss properties of H-free WR stars of the nitrogen sequence (WN stars). Methods: We connected stellar structure models for He stars with wind models for optically thick winds and assessed the degree to which these two types of models can simultaneously fulfil their respective sonic-point conditions. Results: Fixing the outer wind law and terminal wind velocity ν∞, we obtain unique solutions for the mass-loss rates of optically thick, radiation-driven winds of WR stars in the phase of core He-burning. The resulting mass-loss relations as a function of stellar parameters agree well with previous empirical relations. Furthermore, we encounter stellar mass limits below which no continuous solutions exist. While these mass limits agree with observations of WR stars in the Galaxy, they contradict observations in the LMC. Conclusions: While our results in particular confirm the slope of often-used empirical mass-loss relations, they imply that only part of the observed WN population can be understood in the framework of the standard assumptions of a smooth transonic flow and compact stellar core. This means that alternative approaches such as a clumped and inflated wind structure or deviations from the diffusion limit at the sonic point may have to be invoked. Qualitatively, the existence of mass

  20. A Hubble Space Telescope planetary camera view of giant H II regions - The Wolf-Rayet content of NGC 595 and NGC 604 in M33

    NASA Technical Reports Server (NTRS)

    Drissen, Laurent; Moffat, Anthony F. J.; Shara, Michael M.

    1993-01-01

    We present images of NGC 595 and NGC 604, the most massive giant H II regions in M33, obtained with the Planetary Camera aboard the HST in order to study their WR population. Fourteen WR and/or Of candidates are detected in NGC 604, and eleven in NGC 595. All previously claimed 'superluminous' WR stars are found to be tight (diameter less than 3 pc) stellar aggregates containing one (or sometimes more) normal WR star. As suspected from ground-based data, the WR/O number ratio is significantly higher in NGC 595 (about 0.3) than in NGC 604 (about 0.1). The WR stars may be major contributors to the output of mechanical power and energy into the interstellar medium in both clusters. Over the observable initial mass range, the initial mass functions (IMFs) have similar slopes. These IMFs are somewhat flatter than those generally derived for massive stars in the Galaxy or the Magellanic Clouds.

  1. ON THE LAUNCHING AND STRUCTURE OF RADIATIVELY DRIVEN WINDS IN WOLF–RAYET STARS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ro, Stephen; Matzner, Christopher D., E-mail: ro@astro.utoronto.ca

    Hydrostatic models of Wolf–Rayet (WR) stars typically contain low-density outer envelopes that inflate the stellar radii by a factor of several and are capped by a denser shell of gas. Inflated envelopes and density inversions are hallmarks of envelopes that become super-Eddington as they cross the iron-group opacity peak, but these features disappear when mass loss is sufficiently rapid. We re-examine the structures of steady, spherically symmetric wind solutions that cross a sonic point at high optical depth, identifying the physical mechanism through which the outflow affects the stellar structure, and provide an improved analytical estimate for the critical mass-lossmore » rate above which extended structures are erased. Weak-flow solutions below this limit resemble hydrostatic stars even in supersonic zones; however, we infer that these fail to successfully launch optically thick winds. WR envelopes will therefore likely correspond to the strong, compact solutions. We also find that wind solutions with negligible gas pressure are stably stratified at and below the sonic point. This implies that convection is not the source of variability in WR stars, as has been suggested; however, acoustic instabilities provide an alternative explanation. Our solutions are limited to high optical depths by our neglect of Doppler enhancements to the opacity, and do not account for acoustic instabilities at high Eddington factors; yet, they do provide useful insights into WR stellar structures.« less

  2. Using MOST to reveal the secrets of the mischievous Wolf-Rayet binary CV Ser

    NASA Astrophysics Data System (ADS)

    David-Uraz, Alexandre; Moffat, Anthony F. J.; Chené, André-Nicolas; Rowe, Jason F.; Lange, Nicholas; Guenther, David B.; Kuschnig, Rainer; Matthews, Jaymie M.; Rucinski, Slavek M.; Sasselov, Dimitar; Weiss, Werner W.

    2012-11-01

    The Wolf-Rayet (WR) binary CV Serpentis (= WR113, WC8d + O8-9IV) has been a source of mystery since it was shown that its atmospheric eclipses change with time over decades, in addition to its sporadic dust production. The first high-precision time-dependent photometric observations obtained with the Microvariability and Oscillations of STars (MOST) space telescope in 2009 show two consecutive eclipses over the 29-d orbit, with varying depths. A subsequent MOST run in 2010 showed a seemingly asymmetric eclipse profile. In order to help make sense of these observations, parallel optical spectroscopy was obtained from the Mont Megantic Observatory (2009, 2010) and from the Dominion Astrophysical Observatory (2009). Assuming these depth variations are entirely due to electron scattering in a β-law wind, an unprecedented 62 per cent increase in M⊙ is observed over one orbital period. Alternatively, no change in mass-loss rate would be required if a relatively small fraction of the carbon ions in the wind globally recombined and coaggulated to form carbon dust grains. However, it remains a mystery as to how this could occur. There also seems to be evidence for the presence of corotating interaction regions (CIR) in the WR wind: a CIR-like signature is found in the light curves, implying a potential rotation period for the WR star of 1.6 d. Finally, a new circular orbit is derived, along with constraints for the wind collision.

  3. An extensive spectroscopic time series of three Wolf-Rayet stars - I. The lifetime of large-scale structures in the wind of WR 134

    NASA Astrophysics Data System (ADS)

    Aldoretta, E. J.; St-Louis, N.; Richardson, N. D.; Moffat, A. F. J.; Eversberg, T.; Hill, G. M.; Shenar, T.; Artigau, É.; Gauza, B.; Knapen, J. H.; Kubát, J.; Kubátová, B.; Maltais-Tariant, R.; Muñoz, M.; Pablo, H.; Ramiaramanantsoa, T.; Richard-Laferrière, A.; Sablowski, D. P.; Simón-Díaz, S.; St-Jean, L.; Bolduan, F.; Dias, F. M.; Dubreuil, P.; Fuchs, D.; Garrel, T.; Grutzeck, G.; Hunger, T.; Küsters, D.; Langenbrink, M.; Leadbeater, R.; Li, D.; Lopez, A.; Mauclaire, B.; Moldenhawer, T.; Potter, M.; dos Santos, E. M.; Schanne, L.; Schmidt, J.; Sieske, H.; Strachan, J.; Stinner, E.; Stinner, P.; Stober, B.; Strandbaek, K.; Syder, T.; Verilhac, D.; Waldschläger, U.; Weiss, D.; Wendt, A.

    2016-08-01

    During the summer of 2013, a 4-month spectroscopic campaign took place to observe the variabilities in three Wolf-Rayet stars. The spectroscopic data have been analysed for WR 134 (WN6b), to better understand its behaviour and long-term periodicity, which we interpret as arising from corotating interaction regions (CIRs) in the wind. By analysing the variability of the He II λ5411 emission line, the previously identified period was refined to P = 2.255 ± 0.008 (s.d.) d. The coherency time of the variability, which we associate with the lifetime of the CIRs in the wind, was deduced to be 40 ± 6 d, or ˜18 cycles, by cross-correlating the variability patterns as a function of time. When comparing the phased observational grey-scale difference images with theoretical grey-scales previously calculated from models including CIRs in an optically thin stellar wind, we find that two CIRs were likely present. A separation in longitude of Δφ ≃ 90° was determined between the two CIRs and we suggest that the different maximum velocities that they reach indicate that they emerge from different latitudes. We have also been able to detect observational signatures of the CIRs in other spectral lines (C IV λλ5802,5812 and He I λ5876). Furthermore, a DAC was found to be present simultaneously with the CIR signatures detected in the He I λ5876 emission line which is consistent with the proposed geometry of the large-scale structures in the wind. Small-scale structures also show a presence in the wind, simultaneously with the larger scale structures, showing that they do in fact co-exist.

  4. Comprehensive integrated spirometry using raised volume passive and forced expirations and multiple-breath nitrogen washout in infants

    PubMed Central

    Morris, Mohy G.

    2009-01-01

    With the rapid somatic growth and development in infants, simultaneous accurate measurements of lung volume and airway function are essential. Raised volume rapid thoracoabdominal compression (RTC) is widely used to generate forced expiration from an airway opening pressure of 30 cm H2O (V30). The (dynamic) functional residual capacity (FRCdyn) remains the lung volume most routinely measured. The aim of this study was to develop comprehensive integrated spirometry that included all subdivisions of lung volume at V30 or total lung capacity (TLC30). Measurements were performed on seventeen healthy infants aged 8.6–119.7 weeks. A commercial system for multiple-breath nitrogen washout (MBNW) to measure lung volumes and a custom made system to perform RTC were used in unison. A refined automated raised volume RTC and the following two novel single maneuvers with dual volume measurements were performed from V30 during a brief post-hyperventilation apneic pause: (1) the passive expiratory flow was integrated to produce the inspiratory capacity (IC) and the static (passive) FRC (FRCst) was estimated by initiating MBNW after end-passive expiration; (2) RTC was initiated late during passive expiration, flow was integrated to produce the slow vital capacity (jSVC) and the residual volume (RV) was measured by initiating MBNW after end-expiration while the jacket (j) was inflated. Intrasubject FRCdyn and FRCst measurements overlapped (p= 0.6420) but neither did with the RV (p<0.0001). Means (95% confidence interval) of FRCdyn, IC, FRCst, jSVC, RV, forced vital capacity and tidal volume were 21.2 (19.7–22.7), 36.7 (33.0–40.4), 21.2 (19.6–22.8), 40.7 (37.2–44.2), 18.1 (16.6–19.7), 40.7 (37.1–44.2) and 10.2 (9.6–10.7) ml/kg, respectively. Static lung volumes and capacities at V30 and variables from the best forced expiratory flow-volume curve were dependent on age, body length and weight. In conclusion, we developed a comprehensive physiologically

  5. Comprehensive integrated spirometry using raised volume passive and forced expirations and multiple-breath nitrogen washout in infants.

    PubMed

    Morris, Mohy G

    2010-02-28

    With the rapid somatic growth and development in infants, simultaneous accurate measurements of lung volume and airway function are essential. Raised volume rapid thoracoabdominal compression (RTC) is widely used to generate forced expiration from an airway opening pressure of 30 cmH(2)O (V(30)). The (dynamic) functional residual capacity (FRC(dyn)) remains the lung volume most routinely measured. The aim of this study was to develop comprehensive integrated spirometry that included all subdivisions of lung volume at V(30) or total lung capacity (TLC(30)). Measurements were performed on 17 healthy infants aged 8.6-119.7 weeks. A commercial system for multiple-breath nitrogen washout (MBNW) to measure lung volumes and a custom made system to perform RTC were used in unison. A refined automated raised volume RTC and the following two novel single maneuvers with dual volume measurements were performed from V(30) during a brief post-hyperventilation apneic pause: (1) the passive expiratory flow was integrated to produce the inspiratory capacity (IC) and the static (passive) FRC (FRC(st)) was estimated by initiating MBNW after end-passive expiration; (2) RTC was initiated late during passive expiration, flow was integrated to produce the slow vital capacity ((j)SVC) and the residual volume (RV) was measured by initiating MBNW after end-expiration while the jacket (j) was inflated. Intrasubject FRC(dyn) and FRC(st) measurements overlapped (p=0.6420) but neither did with the RV (p<0.0001). Means (95% confidence interval) of FRC(dyn), IC, FRC(st), (j)SVC, RV, forced vital capacity and tidal volume were 21.2 (19.7-22.7), 36.7 (33.0-40.4), 21.2 (19.6-22.8), 40.7 (37.2-44.2), 18.1 (16.6-19.7), 40.7 (37.1-44.2) and 10.2 (9.6-10.7)ml/kg, respectively. Static lung volumes and capacities at V(30) and variables from the best forced expiratory flow-volume curve were dependent on age, body length and weight. In conclusion, we developed a comprehensive physiologically integrated

  6. The Wolf-Rayet star population in the dwarf galaxy NGC 625

    NASA Astrophysics Data System (ADS)

    Monreal-Ibero, A.; Walsh, J. R.; Iglesias-Páramo, J.; Sandin, C.; Relaño, M.; Pérez-Montero, E.; Vílchez, J.

    2017-07-01

    Context. Quantifying the number, type, and distribution of Wolf-Rayet (W-R) stars is a key component in the context of galaxy evolution, since they put constraints on the age of the star formation bursts. Nearby galaxies (distances ≲5 Mpc) are particularly relevant in this context since they fill the gap between studies in the Local Group, where individual stars can be resolved, and galaxies in the Local Volume and beyond. Aims: We intend to characterise the W-R star population in one of these systems, NGC 625, which is a low-metallicity dwarf galaxy suffering a currently declining burst of star formation. Methods: Optical integral field spectroscopy (IFS) data have been obtained with the VIMOS-IFU and the HR_Orange and HR_Blue gratings at the Very Large Telescope covering the starburst region of NGC 625. Ancillary Hubble Space Telescope (HST) images in the F555W and F814W bands are also used for comparison. We estimate the number of W-R stars using a linear combination of three W-R templates: one early-type nitrogen (WN) star, one late-type WN star, and one carbon-type (WC) star (or oxygen-type (WO) star). Fits using several ensembles of templates were tested. Results were confronted with I) high spatial resolution HST photometry; II) numbers of W-R stars in nearby galaxies; and III) model predictions. Results: The W-R star population is spread over the main body of the galaxy and is not necessarily coincident with the overall stellar distribution. Our best estimation for the number of W-R stars yields a total of 28 W-R stars in the galaxy, out of which 17 are early-type WN, six are late-type WN, and five are WC stars. The width of the stellar features nicely correlates with the dominant W-R type found in each aperture. The distribution of the different types of WR in the galaxy is roughly compatible with the way star formation has propagated in the galaxy, according to previous findings using high spatial resolution with the HST. Fits using templates at the

  7. Simultaneous Introduction of a Novel High Fat Diet and Wheel Running Induces Anorexia

    PubMed Central

    Scarpace, E. T.; Matheny, M.; Strehler, K. Y. E.; Shapiro, A.; Cheng, K. Y.; Tümer, N.; Scarpace, P. J.

    2011-01-01

    Voluntary wheel running (WR) is a form of physical activity in rodents that influences ingestive behavior. The present report describes an anorexic behavior triggered by the simultaneous introduction of a novel diet and WR. This study examined the sequential, compared with the simultaneous, introduction of a novel high-fat (HF) diet and voluntary WR in rats of three different ages and revealed a surprising finding; the simultaneous introduction of HF food and voluntary WR induced a behavior in which the animals chose not to eat although food was available at all times. This phenomenon was apparently not due to an aversion to the novel HF diet because introduction of the running wheels plus the HF diet, while continuing the availability of the normal chow diet did not prevent the anorexia. Moreover, the anorexia was prevented with prior exposure to the HF diet. In addition, the anorexia was not related to extent of WR but dependent on the act of WR. The introduction a HF diet and locked running wheels did not induce the anorexia. This voluntary anorexia was accompanied by substantial weight loss, and the anorexia was rapidly reversed by removal of the running wheels. Moreover, the HF/WR-induced anorexia is preserved across the age span despite the intrinsic decrease in WR activity and increased consumption of HF food with advancing age. The described phenomenon provides a new model to investigate anorexia behavior in rodents. PMID:22115947

  8. Winds from the S-Star Cluster Reduce the Accretion Rate onto Sgr A*

    NASA Astrophysics Data System (ADS)

    Yusef-Zadeh, Farhad; Wardle, M.; Roberts, D. A; Haggard, Daryl; Lacy, John H.; Royster, Marc; Cotton, William D.

    2014-06-01

    High-resolution radio continuum images of the region within a few arcseconds of Sgr A* at wavelengths of 7 and 12 mm show three new radio structures. One is a 2-3'' hollow teardrop-shaped structure centered on Sgr A*. Highly blue-shifted [NeII] and [FeIII] line emission is detected along the boundary of this teardrop-shaped bubble, ~2.2'' south of Sgr A*. The second structure is a faint, incomplete ring surrounding Sgr A* with typical surface brightness at 7 mm of ~0.1 mJy per ~0.04'' x 0.08'' beam. This partial ring coincides with the outer boundary of the S-star cluster which consists of ~30 B dwarfs orbiting within 1'' of Sgr A*. Lastly, on a scale of ~20'' to the N of Sgr A*, a balloon-shaped structure is detected.We interpret that the new morphological and kinematic structures result from the dynamical effects of a combined cluster wind. This wind is created at a rate ~3 x 10^{-5} solar mass per year by the merging of individual stellar winds from the B stars in the S-star cluster. What is significant about this interpretation is that the expanding wind excludes the shocked winds from O and WR stars in the central parsec of the Galaxy. Meanwhile Sgr A* accretes material from within the S cluster at a rate less than or equal 3 x 10^{-7} solar mass per year, thus explaining the low luminosity of Sgr A* without the ejection of a large fraction of the accreted material.

  9. The origin of extended interstellar shells around Wolf-Rayet stars having bright optical ring nebulae

    NASA Technical Reports Server (NTRS)

    Nichols, J. S.; Fesen, R. A.

    1994-01-01

    Investigations of the interstellar environment around Wolf-Rayet (WR) stars have lead to the discovery of extended shells of gas and dust 50-100 pc in diameter in the lines of sight toward three WR stars. In this paper, several origins for these extended shells are discussed. While positional coincidences cannot be excluded, the locations of the WR stars near the projected centers of the shells, the detection of only shortward-shifted, high-velocity UV absorption line components in their IUE spectra, plus commonality of some WR star properties which are rare in the general WR star population suggest some casual connections between the WR stars and formation of interstellar shells. To access whether the high-velocity UV interstellar absorption lines are a frequent phenomenon related to WR stellar winds, we present a survey of such features in all WR stars observed with IUE through 1991. Of 35 stars studied, only four are found to have components with velocity displacements greater than 45 km/s which are not attributable to previously identified OB association superbubbles. The means a surprising 82% of non-OB association WR stars show no evidence of high-velocity gas in their lines of sight at IUE's spectral resolution, suggesting that high-velocity interstellar absorption lines are not a common consequence of Wolf-Rayet star stellar winds alone. We review the properties of three WR stars (HD 50896, HD 96548, and HD 192163) which may reside inside extended interstellar shells and find that they are similar in terms of spectral class (WN5-8), presence of an optical ring nebula, and reported photometric variability. Evaluation of possible origins of the extended shells suggests these three stars are in a post X-ray binary stage of high-mass binary star evolution. If this is correct, then the large interstellar shells detected might be evidence of either supernova remnant shells generated by the explosion of the binary's primary star, or non-conservative mass transfer

  10. Wolf-Rayet spin at low metallicity and its implication for black hole formation channels

    NASA Astrophysics Data System (ADS)

    Vink, Jorick S.; Harries, Tim J.

    2017-07-01

    Context. The spin of Wolf-Rayet (WR) stars at low metallicity (Z) is most relevant for our understanding of gravitational wave sources, such as GW 150914, and of the incidence of long-duration gamma-ray bursts (GRBs). Two scenarios have been suggested for both phenomena: one of them involves rapid rotation and quasi-chemical homogeneous evolution (CHE) and the other invokes classical evolution through mass loss in single and binary systems. Aims: The stellar spin of WR stars might enable us to test these two scenarios. In order to obtain empirical constraints on black hole progenitor spin we infer wind asymmetries in all 12 known WR stars in the Small Magellanic Cloud (SMC) at Z = 1 / 5 Z⊙ and within a significantly enlarged sample of single and binary WR stars in the Large Magellanic Cloud (LMC at Z = 1 / 2 Z⊙), thereby tripling the sample of Vink from 2007. This brings the total LMC sample to 39, making it appropriate for comparison to the Galactic sample. Methods: We measured WR wind asymmetries with VLT-FORS linear spectropolarimetry, a tool that is uniquely poised to perform such tasks in extragalactic environments. Results: We report the detection of new line effects in the LMC WN star BAT99-43 and the WC star BAT99-70, along with the well-known WR LBV HD 5980 in the SMC, which might be undergoing a chemically homogeneous evolution. With the previous reported line effects in the late-type WNL (Ofpe/WN9) objects BAT99-22 and BAT99-33, this brings the total LMC WR sample to four, I.e. a frequency of 10%. Perhaps surprisingly, the incidence of line effects amongst low Z WR stars is not found to be any higher than amongst the Galactic WR sample, challenging the rotationally induced CHE model. Conclusions: As WR mass loss is likely Z-dependent, our Magellanic Cloud line-effect WR stars may maintain their surface rotation and fulfill the basic conditions for producing long GRBs, both via the classical post-red supergiant or luminous blue variable channel, or

  11. Plankton community respiration, net ecosystem metabolism, and oxygen dynamics on the Louisiana continental shelf: implications for hypoxia

    EPA Science Inventory

    We conducted a multi-year study of the Louisiana continental shelf (LCS) to better understand the linkages between water column metabolism and the formation of hypoxia (dissolved oxygen <2 mg L-1) in the region. Water column community respiration rates (WR) were measured on 10 cr...

  12. Return-to-work challenges following a work-related mild TBI: The injured worker perspective.

    PubMed

    Mansfield, Elizabeth; Stergiou-Kita, Mary; Cassidy, John David; Bayley, Mark; Mantis, Steve; Kristman, Vicki; Kirsh, Bonnie; Gomez, Manuel; Jeschke, Mark G; Vartanian, Oshin; Moody, Joel; Colantonio, Angela

    2015-01-01

    To explore how individuals with work-related mild traumatic brain injury (wrMTBI) experience return-to-work (RTW) processes when returning to the workplace where the injury occurred. RTW experiences were explored using in-depth interviews and an inductive analytic approach. Qualitative analysis guided by the research question moved through phases of line-by-line and thematic coding through which categories and the interaction between categories emerged. Twelve workers diagnosed with a wrMTBI reported on their RTW experiences following wrMTBIs that occurred 3-5 years prior to the time of the interview. Participants perceived employer and workers' compensation factors as profoundly influencing their RTW experiences. Participants consistently reported that employers and workers' compensation representatives had an inadequate understanding of wrMTBI sequelae. Six of 12 participants were re-injured following their wrMTBI, with three of these injuries occurring at work. Employers, co-workers and workers' compensation representatives should be aware of wrMTBI sequelae so injured workers can receive appropriate supports and both stigmatization and re-injury can be mitigated. Greater attention to the structural and social elements of workplace and compensation environments could inform strategies to break down barriers to successful return-to-work following a wrMTBI.

  13. Return-to-work challenges following a work-related mild TBI: The injured worker perspective.

    PubMed

    Mansfield, Elizabeth; Stergiou-Kita, Mary; Cassidy, John David; Bayley, Mark; Mantis, Steve; Kristman, Vicki; Kirsh, Bonnie; Gomez, Manuel; Jeschke, Mark G; Vartanian, Oshin; Moody, Joel; Colantonio, Angela

    2015-08-07

    To explore how individuals with work-related mild traumatic brain injury (wrMTBI) experience return-to-work (RTW) processes when returning to the workplace where the injury occurred. RTW experiences were explored using in-depth interviews and an inductive analytic approach. Qualitative analysis guided by the research question moved through phases of line-by-line and thematic coding through which categories and the interaction between categories emerged. Twelve workers diagnosed with a wrMTBI reported on their RTW experiences following wrMTBIs that occurred 3-5 years prior to the time of the interview. Participants perceived employer and workers' compensation factors as profoundly influencing their RTW experiences. Participants consistently reported that employers and workers' compensation representatives had an inadequate understanding of wrMTBI sequelae. Six of 12 participants were re-injured following their wrMTBI, with three of these injuries occurring at work. Employers, co-workers and workers' compensation representatives should be aware of wrMTBI sequelae so injured workers can receive appropriate supports and both stigmatization and re-injury can be mitigated. Greater attention to the structural and social elements of workplace and compensation environments could inform strategies to break down barriers to successful return-to-work following a wrMTBI.

  14. Soil suppressiveness to fusarium disease: shifts in root microbiome associated with reduction of pathogen root colonization.

    PubMed

    Klein, Eyal; Ofek, Maya; Katan, Jaacov; Minz, Dror; Gamliel, Abraham

    2013-01-01

    Soil suppressiveness to Fusarium disease was induced by incubating sandy soil with debris of wild rocket (WR; Diplotaxis tenuifolia) under field conditions. We studied microbial dynamics in the roots of cucumber seedlings following transplantation into WR-amended or nonamended soil, as influenced by inoculation with Fusarium oxysporum f. sp. radicis-cucumerinum. Disease symptoms initiated in nonamended soil 6 days after inoculation, compared with 14 days in WR-amended soil. Root infection by F. oxysporum f. sp. radicis-cucumerinum was quantified using real-time polymerase chain reaction (PCR). Target numbers were similar 3 days after inoculation for both WR-amended and nonamended soils, and were significantly lower (66%) 6 days after inoculation and transplanting into the suppressive (WR-amended) soil. This decrease in root colonization was correlated with a reduction in disease (60%) 21 days after inoculation and transplanting into the suppressive soil. Fungal community composition on cucumber roots was assessed using mass sequencing of fungal internal transcribed spacer gene fragments. Sequences related to F. oxysporum, Fusarium sp. 14005, Chaetomium sp. 15003, and an unclassified Ascomycota composed 96% of the total fungal sequences in all samples. The relative abundances of these major groups were highly affected by root inoculation with F. oxysporum f. sp. radicis-cucumerinum, with a 10-fold increase in F. oxysporum sequences, but were not affected by the WR amendment. Quantitative analysis and mass-sequencing methods indicated a qualitative shift in the root's bacterial community composition in suppressive soil, rather than a change in bacterial numbers. A sharp reduction in the size and root dominance of the Massilia population in suppressive soil was accompanied by a significant increase in the relative abundance of specific populations; namely, Rhizobium, Bacillus, Paenibacillus, and Streptomyces spp. Composition of the Streptomyces community shifted

  15. In pursuit of gamma-ray burst progenitors: the identification of a sub-population of rotating Wolf-Rayet stars

    NASA Astrophysics Data System (ADS)

    Vink, J. S.; Gräfener, G.; Harries, T. J.

    2011-12-01

    Long-duration gamma-ray bursts (GRBs) involve the most powerful cosmic explosions since the Big Bang. Whilst it has been established that GRBs are related to the death throes of massive stars, the identification of their elusive progenitors has proved challenging. Theoretical modelling suggests that rotating Wolf-Rayet (WR) stars are the best candidates. Wolf-Rayet stars are thought to be in advanced core burning stages, just prior to explosion, but their strong stellar winds shroud their surfaces, preventing a direct measurement of their rotation. Fortunately, linear spectropolarimetry may be used to probe the flattening of their winds because of stellar spin. Spectropolarimetry surveys have shown that the vast majority of WR stars (80%) have spherically symmetric winds and are therefore rotating slowly, yet a small minority (of 20%) display a spectropolarimetric signature indicative of rotation. Here we find a highly significant correlation between WR objects that carry the signature of stellar rotation and the small subset of WR stars with ejecta nebulae that have only recently transitioned from a previous red sugergiant or luminous blue variable phase. As these youthful WR stars have yet to spin-down because of mass loss, they are the best candidate GRB progenitors identified to date. When we take recently published WR ejecta nebula numbers (of Stock & Barlow 2010, MNRAS, 409, 1429), we find that five out of the six line-effect WR stars are surrounded by ejecta nebulae. The statistics imply that the null hypothesis of no correlation between line-effect WR stars and ejecta nebulae can be rejected at the 0.0004% level. Given that four line-effect and WR ejecta nebula have spectroscopically been confirmed to contain nucleo-synthetic products, we argue that the correlation is both statistically significant and physically convincing. The implication is that we have identified a sub-population of WR stars that fulfils the necessary criteria for making GRBs. Finally

  16. Repeatability and genotypic correlations of reproductive and productive traits of crossbred beef cattle dams.

    PubMed

    Silva, L N; Gasparino, E; Torres Júnior, R A A; Euclides Filho, K; Silva, L O C; Alencar, M M; Souza Júnior, M D; Battistelli, J V F; Silva, S C C

    2015-05-22

    Beef cattle production requires reproductive efficiency. However, measures of reproductive traits are not usually collected; consequently, correlated traits that could be used as indicators would be useful. We examined associations between measures of reproductive and productive efficiency that could be used as selection indicators. Data from 194 dams of the genetic groups Angus x Nelore, Caracu x Nelore, and Valdostana x Nelore collected over 4 years were used. The reproductive traits analyzed were days to heat (DH), calving interval (CI), days to calving (DC), and pregnancy rate (PR). The productive traits were dam weight (DW), body condition score (BCS), calf weight (CW), and weaning rate (WR). The effects on the model were: year, genetic group, reproductive status (RS), age, reproductive rest, and breed of bull (CW and WR). Multivariate analyses were performed, using the Bayesian approach via Gibbs sampling. We conclude that the reproductive measures are ineffective as selection indicators, whereas using dam weight may be a good alternative.

  17. Non-motor symptoms and cardiac innervation in SYNJ1-related parkinsonism.

    PubMed

    De Rosa, A; Pellegrino, T; Pappatà, S; Lieto, M; Bonifati, V; Palma, V; Topa, A; Santoro, L; Bilo, L; Cuocolo, A; De Michele, G

    2016-02-01

    PARK20 is a rare autosomal recessive parkinsonism related to the SYNJ1 gene and characterized by early-onset of disease and atypical signs such as supranuclear vertical gaze palsy, dementia, dystonia, and generalized tonic-clonic seizures. Non-motor features and cardiac sympathetic innervation were assessed in two siblings affected by parkinsonism who harboured the homozygous Arg258Gln mutation in the SYNJ1 gene. The Non-Motor Symptoms, the SCOPA-AUT, the Mayo Sleep Questionnaires and polysomnography were used to investigate non-motor signs (NMS), autonomic dysfunction and REM Behavioural Disorder (RBD). Cognitive functions were examined by an extensive battery of neuropsychological tests. In addition, motor and sensory nerve conduction studies and evoked laser potentials were performed. Cardiac sympathetic innervation was assessed in the two patients by (123)I-metaiodobenzylguanidine (MIBG) scintigraphy, computing early and late heart-to-mediastinum (H/M) ratios and myocardial washout rates (WR). Among the non-motor symptoms and autonomic signs, case 1 had cold intolerance, drooling and dysphagia, while case 2 had pain and urinary dysfunction. Both cases showed mood and behavioural disorders. RBD were not found, whereas the neuropsychological assessment revealed a progressive cognitive impairment. Neurophysiological studies revealed no abnormalities. Indexes of cardiac sympathetic innervation in the two patients did not differ from those of control subjects. Our findings expand the phenotypic profile of SYNJ1-related parkinsonism. Preserved cardiac sympathetic function and absence of RBD suggest that PARK20 should be explained by a pathogenic mechanism different from Lewy Body pathology, or that the latter is not as widespread as idiopathic Parkinson's disease. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. X-ray Observations of Binary and Single Wolf-Rayet Stars with XMM-Newton and Chandra

    NASA Technical Reports Server (NTRS)

    Skinner, Stephen; Gudel, Manuel; Schmutz, Werner; Zhekov, Svetozar

    2006-01-01

    We present an overview of recent X-ray observations of Wolf-Rayet (WR) stars with XMM-Newton and Chandra. These observations are aimed at determining the differences in X-ray properties between massive WR + OB binary systems and putatively single WR stars. A new XMM spectrum of the nearby WN8 + OB binary WR 147 shows hard absorbed X-ray emission (including the Fe Ka line complex), characteristic of colliding wind shock sources. In contrast, sensitive observations of four of the closest known single WC (carbon-rich) WR stars have yielded only nondetections. These results tentatively suggest that single WC stars are X-ray quiet. The presence of a companion may thus be an essential factor in elevating the X-ray emission of WC + OB stars to detectable levels.

  19. Newly discovered Wolf-Rayet and weak emission-line central stars of planetary nebulae

    NASA Astrophysics Data System (ADS)

    DePew, K.; Parker, Q. A.; Miszalski, B.; De Marco, O.; Frew, D. J.; Acker, A.; Kovacevic, A. V.; Sharp, R. G.

    2011-07-01

    We present the spectra of 32 previously unpublished confirmed and candidate Wolf-Rayet ([WR]) and weak emission-line (WELS) central stars of planetary nebulae (CSPNe). 18 stars have been discovered in the Macquarie/AAO/Strasbourg Hα (MASH) PN survey sample, and we have also uncovered 14 confirmed and candidate [WR]s and WELS among the CSPNe of previously known PNe. Spectral classifications have been undertaken using both Acker & Neiner and Crowther, De Marco & Barlow schemes. 22 members in this sample are identified as probable [WR]s; the remaining 10 appear to be WELS. Observations undertaken as part of the MASH spectroscopic survey have now increased the number of known [WR]s by ˜30 per cent. This will permit a better analysis of [WR] subclass distribution, metallicity effects and evolutionary sequences in these uncommon objects.

  20. Rectosigmoid stump washout as an alternative to permanent mucous fistula in patients undergoing subtotal colectomy for ulcerative colitis in emergency settings.

    PubMed

    Pellino, Gianluca; Sciaudone, Guido; Candilio, Giuseppe; Canonico, Silvestro; Selvaggi, Francesco

    2012-01-01

    Restorative proctocolectomy with ileopouch-anal anastomosis (IPAA) is the treatment of choice for intractable or complicated ulcerative colitis(UC). Elderly patients often present with acute colitis requiring emergent subtotal colectomy(SC). Frail patients are at risk of developing septic complications related to the closed rectosigmoidal stump, often requiring formation of a second stoma to be reversed at the time of completion proctectomy. This carries nuisance to such exhausted patients. We propose a simple and inexpensive trick to avoid the need for creating a mucous fistula. IPAA was performed as a 3-stage procedure in emergency settings. The rectosigmoidal stump was closed and placed subcutaneously; skin was closed over it. After SC, if patients showed signs of stump-related pelvic sepsis, a lavage of the rectal stump with povidone iodine solution and with saline was carried out as a rescue treatment aiming to avoid the need of opening the rectal stump to drain sepsis. Thirty-five patients underwent SC for UC between 1987 and 2012. The skin was closed over the closed stump in the 20. Seven patients out of these 20 experienced early stump-related septic complication. In five cases, we were able to avoid opening of the rectal stump, and a second stoma was unnecessary. After opening the closed stump in the remaining ones, a prompt improving of symptoms was observed. Rectal washout was well tolerated and avoided a second stoma in five out of seven patients, with better quality of life and body perception after IPAA surgery. This is relevant when dealing with geriatric patients, needing to completely recover before undergoing completion proctectomy.

  1. Providing feedback following Leadership WalkRounds is associated with better patient safety culture, higher employee engagement and lower burnout

    PubMed Central

    Sexton, J Bryan; Adair, Kathryn C; Leonard, Michael W; Frankel, Terri Christensen; Proulx, Joshua; Watson, Sam R; Magnus, Brooke; Bogan, Brittany; Jamal, Maleek; Schwendimann, Rene; Frankel, Allan S

    2018-01-01

    Background There is a poorly understood relationship between Leadership WalkRounds (WR) and domains such as safety culture, employee engagement, burnout and work-life balance. Methods This cross-sectional survey study evaluated associations between receiving feedback about actions taken as a result of WR and healthcare worker assessments of patient safety culture, employee engagement, burnout and work-life balance, across 829 work settings. Results 16 797 of 23 853 administered surveys were returned (70.4%). 5497 (32.7% of total) reported that they had participated in WR, and 4074 (24.3%) reported that they participated in WR with feedback. Work settings reporting more WR with feedback had substantially higher safety culture domain scores (first vs fourth quartile Cohen’s d range: 0.34–0.84; % increase range: 15–27) and significantly higher engagement scores for four of its six domains (first vs fourth quartile Cohen’s d range: 0.02–0.76; % increase range: 0.48–0.70). Conclusion This WR study of patient safety and organisational outcomes tested relationships with a comprehensive set of safety culture and engagement metrics in the largest sample of hospitals and respondents to date. Beyond measuring simply whether WRs occur, we examine WR with feedback, as WR being done well. We suggest that when WRs are conducted, acted on, and the results are fed back to those involved, the work setting is a better place to deliver and receive care as assessed across a broad range of metrics, including teamwork, safety, leadership, growth opportunities, participation in decision-making and the emotional exhaustion component of burnout. Whether WR with feedback is a manifestation of better norms, or a cause of these norms, is unknown, but the link is demonstrably potent. PMID:28993441

  2. An IRAS-Based Search for New Dusty Late-Type WC Wolf-Rayet Stars

    NASA Technical Reports Server (NTRS)

    Cohen, Martin

    1995-01-01

    I have examined all Infrared Astronomical Satellite (IRAS) data relevant to the 173 Galactic Wolf-Rayet (W-R) stars in an updated catalog, including the 13 stars newly discovered by Shara and coworkers. Using the W-R coordinates in these lists, I have examined the IRAS Point Source Catalog (PSC), the Faint Source Catalog, and the Faint Source Reject Catalog, and have generated one-dimensional spatial profiles, 'ADDSCANs', and two-dimensional full-resolution images, 'FRESCOS'. The goal was to assemble the best set of observed IRAS color indices for different W-R types, in particular for known dusty late-type WC Wolf-Rayet (WCL) objects. I have also unsuccessfully sought differences in IRAS colors and absolute magnitudes between single and binary W-R stars. The color indices for the entire ensemble of W-R stars define zones in the IRAS color-color ([12] - [25], [25] - [60])-plane. By searching the PSC for otherwise unassociated sources that satisfy these colors, I have identified potential new W-R candidates, perhaps too faint to have been recognized in previous optical searches. I have extracted these candidates' IRAS low-resolution spectrometer (LRS) data and compared the spectra with the highly characteristic LRS shape for known dusty WCL stars. The 13 surviving candidates must now be ex amined by optical spectroscopy. This work represents a much more rigorous and exhaustive version of the LRS study that identified IRAS 17380 - 3031 (WR98a) as the first new W-R (WC9) star discovered by IPAS. This search should have detected dusty WCL stars to a distance of 7.0 kpc from the Sun, for l is greater than 30 degrees, and to 2.9 kpc even in the innermost galaxy. For free-free-dominated W-R stars the corresponding distances are 2.5 and 1.0 kpc, respectively.

  3. An IRAS-based search for new Dusty Late-Type WC Wolf-Rayet stars

    NASA Technical Reports Server (NTRS)

    Cohen, Martin

    1995-01-01

    I have examined all Infrared Astronomical Satellite (IRAS) data relevant to the 173 Galactic Wolf-Rayet (W-R) stars in an updated catalog, including the 13 stars newly discovered by Shara and coworkers. Using the W-R coordinates in these lists, I have examined the IRAS Point Source Catalog (PSC), the Faint Source Catalog, and the Faint Source Reject Catalog, and have generated one-dimensional spatial profiles ('ADDSCANs') and two-dimensional full-resolution images ('FRESCOs'). The goal was to assemble the best set of observed IRAS color indices for different W-R types, in particular for known dusty late-type WC Wolf-Rayet (WCL) objects. I have also unsuccessfully sought differences in IRAS colors and absolute magnitudes between single and binary W-R stars. The color indices for the entire ensemble of W-R stars define zones in the IRAS color-color plane. By searching the PSC for otherwise unassociated sources that satisfy these colors, I have identified potential new W-R candidates, perhaps too faint to have been recognized in previous optical searches. I have extracted these candidates' IRAS low-resolution spectrometer (LRS) data and compared the spectra with the highly characteristic LRS shape for known dusty WCL stars. The 13 surviving candidates must now be examined by optical spectroscopy. This work represents a much more rigorous and exhaustive version of the LRS study that identified IRAS 17380 - 3031 (WR98a) as the first new W-R (WC9) star discovered by IRAS. This search should have detected dusty WCL stars to a distance of 7.0 kpc from the Sun, for the absolute value of l greater than 30 deg, and to 2.9 kpc even in the innermost Galaxy. For free-free-dominated W-R stars the corresponding distances are 2.5 and 1.0 kpc, respectively.

  4. Providing feedback following Leadership WalkRounds is associated with better patient safety culture, higher employee engagement and lower burnout.

    PubMed

    Sexton, J Bryan; Adair, Kathryn C; Leonard, Michael W; Frankel, Terri Christensen; Proulx, Joshua; Watson, Sam R; Magnus, Brooke; Bogan, Brittany; Jamal, Maleek; Schwendimann, Rene; Frankel, Allan S

    2018-04-01

    There is a poorly understood relationship between Leadership WalkRounds (WR) and domains such as safety culture, employee engagement, burnout and work-life balance. This cross-sectional survey study evaluated associations between receiving feedback about actions taken as a result of WR and healthcare worker assessments of patient safety culture, employee engagement, burnout and work-life balance, across 829 work settings. 16 797 of 23 853 administered surveys were returned (70.4%). 5497 (32.7% of total) reported that they had participated in WR, and 4074 (24.3%) reported that they participated in WR with feedback. Work settings reporting more WR with feedback had substantially higher safety culture domain scores (first vs fourth quartile Cohen's d range: 0.34-0.84; % increase range: 15-27) and significantly higher engagement scores for four of its six domains (first vs fourth quartile Cohen's d range: 0.02-0.76; % increase range: 0.48-0.70). This WR study of patient safety and organisational outcomes tested relationships with a comprehensive set of safety culture and engagement metrics in the largest sample of hospitals and respondents to date. Beyond measuring simply whether WRs occur, we examine WR with feedback, as WR being done well . We suggest that when WRs are conducted, acted on, and the results are fed back to those involved, the work setting is a better place to deliver and receive care as assessed across a broad range of metrics, including teamwork, safety, leadership, growth opportunities, participation in decision-making and the emotional exhaustion component of burnout. Whether WR with feedback is a manifestation of better norms, or a cause of these norms, is unknown, but the link is demonstrably potent. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  5. Color excesses, intrinsic colors, and absolute magnitudes of Galactic and Large Magellanic Cloud Wolf-Rayet stars

    NASA Technical Reports Server (NTRS)

    Vacca, William D.; Torres-Dodgen, Ana V.

    1990-01-01

    A new method of determining the color excesses of WR stars in the Galaxy and the LMC has been developed and is used to determine the excesses for 44 Galactic and 32 LMC WR stars. The excesses are combined with line-free, narrow-band spectrophotometry to derive intrinsic colors of the WR stars of nearly all spectral subtypes. No correlation of UV spectral index or intrinsic colors with spectral subtype is found for the samples of single WN or WC stars. There is evidence that early WN stars in the LMC have flatter UV continua and redder intrinsic colors than early WN stars in the Galaxy. No separation is found between the values derived for Galactic WC stars and those obtained for LMC WC stars. The intrinsic colors are compared with those calculated from model atmospheres of WR stars and generally good agreement is found. Absolute magnitudes are derived for WR stars in the LMC and for those Galactic WR stars located in clusters and associations for which there are reliable distance estimates.

  6. Relationships among the serum omega fatty acid levels, serum C-reactive protein levels and arterial stiffness/wave reflection in Japanese men.

    PubMed

    Tomiyama, Hirofumi; Matsumoto, Chisa; Odaira, Mari; Yamada, Jiko; Yoshida, Masanobu; Shiina, Kazuki; Nagata, Mikio; Yamashina, Akira

    2011-08-01

    We examined the relationship among the serum omega-3 and omega-6 fatty acid (O3FA and O6FA) levels, serum C-reactive protein (CRP) levels, and arterial stiffness/wave reflection (AS/WR) in healthy Japanese men. In 2206 Japanese healthy men, parameters related to the AS/WR (i.e., brachial-ankle pulse wave velocity and radial arterial pulse wave analysis) were measured. No significant inverse relationships were observed between the serum O3FA levels and the AS/WR-related parameters. Adjusted values of the AS/WR-related parameters and serum CRP levels were higher in the subjects with serum O6FA levels in the highest tertile than in those with serum O6FA levels in the lowest tertile. In healthy Japanese men with known high dietary intakes of O3FAs, the serum O3FA levels may not reflect the pathophysiological abnormalities related to AS/WR. Increased serum O6FA levels appeared to be independently associated with the unfavorable conditions related to AS/WR and inflammation. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  7. Preoperative antibiotics for septic arthritis in children: delay in diagnosis.

    PubMed

    MacLean, Simon B M; Timmis, Christopher; Evans, Scott; Lawniczak, Dominik; Nijran, Amit; Bache, Edward

    2015-04-01

    To review the records of 50 children who underwent open joint washout for septic arthritis with (n=25) or without (n=25) preoperative antibiotics. Records of 50 children who underwent open joint washout for presumed septic arthritis with (n=25) or without (n=25) preoperative antibiotics were reviewed. 17 boys and 8 girls aged 3 weeks to 16 years (median, 1.5 years) who were prescribed preoperative antibiotics before joint washout were compared with 12 boys and 13 girls aged one month to 14 years (median, 2 years) who were not. Following arthrotomy and washout, all patients were commenced on high-dose intravenous antibiotics. Patients were followed up for 6 to 18 months until asymptomatic. Patients who were referred from places other than our emergency department were twice as likely to have been prescribed preoperative antibiotics (p=0.0032). Patients prescribed preoperative antibiotics had a longer median (range) time from symptom onset to joint washout (8 [2-23] vs. 4 [1-29] days, p=0.05) and a higher mean erythrocyte sedimentation rate (93.1 vs. 54.3 mm/h, p=0.023) at presentation. Nonetheless, the 2 groups were comparable for weight bearing status, fever, and positive culture, as well as the mean (range) duration of antibiotic treatment (4.9 [4-7] vs. 4.7 [1-8] weeks, p=0.586). Preoperative antibiotics should be avoided in the management of septic arthritis in children. Their prescription delays diagnosis and definitive surgery, and leads to additional washouts and complications. A high index of suspicion and expedite referral to a specialist paediatric orthopaedic unit is needed if septic arthritis is suspected.

  8. The extent to which the public health 'war on obesity' reflects the ethical values and principles of critical health promotion: a multimedia critical discourse analysis.

    PubMed

    O'Hara, Lily; Taylor, Jane; Barnes, Margaret

    2015-12-01

    The discipline of health promotion is responsible for implementing strategies within weight-related public health initiatives (WR-PHI). It is imperative that such initiatives be subjected to critical analysis through a health promotion ethics lens to help ensure ethical health promotion practice. Multimedia critical discourse analysis was used to examine the claims, values, assumptions, power relationships and ideologies within Australian WR-PHI. The Health Promotion Values and Principles Continuum was used as a heuristic to evaluate the extent to which the WR-PHI reflected the ethical values of critical health promotion: active participation of people in the initiative; respect for personal autonomy; beneficence; non-maleficence; and strong evidential and theoretical basis for practice. Ten initiatives were analysed. There was some discourse about the need for participation of people in the WR-PHI, but people were routinely labelled as 'target groups' requiring 'intervention'. Strong evidence of a coercive and paternalistic discourse about choice was identified, with minimal attention to respect for personal autonomy. There was significant emphasis on the beneficiaries of the WR-PHI but minimal attention to the health benefits, and nothing about the potential for harm. Discourse about the evidence of need was objectivist, and there was no discussion about the theoretical foundations of the WR-PHI. The WR-PHI were not reflective of the ethical values and principles of critical health promotion. So what? Health promotion researchers and practitioners engaged in WR-PHI should critically reflect on the extent to which they are consistent with the ethical aspects of critical health promotion practice.

  9. Bearing the brunt: co-workers' experiences of work reintegration processes.

    PubMed

    Dunstan, Debra A; MacEachen, Ellen

    2013-03-01

    Work disability research has found co-worker support to be a significant but under-recognised aspect of work reintegration (WR) processes. Although co-workers work alongside returning workers, their practical contribution to WR success or failure is often invisible to others. This study aimed to gain further insight into the role and contribution of co-workers in WR interventions. An exploratory qualitative pilot study was conducted in Toronto, Canada in 2011. Three focus groups were conducted with 13 co-workers, recruited for their direct experience of 'working alongside' a returning worker. An iterative data gathering and analysis process occurred. Themes were generated from categories in open-ended interview questions and new issues arising from the data. The findings detail co-workers' practical experiences of WR processes and their reflections on social and work conditions that impacted their participation. Co-workers' capacity to support returning workers was related to the quality of the WR arrangements, the relationship with the returning worker, work culture, and the duration of the required support. Workplace privacy and confidentiality requirements were identified as a key challenge for co-worker participation. The effects on co-workers of WR processes ranged from the opportunity to learn new skills to disillusionment and withdrawal from the workplace. In worst case scenarios, 'ripple effects' including emotional distress, physical injury and termination of co-workers' employment had occurred. Co-workers are not a neutral party in WR procedures. Formalizing the co-worker role to include communication, consideration and recognition might improve co-workers' WR experiences.

  10. Wolf-Rayet content of the Milky Way

    NASA Astrophysics Data System (ADS)

    Crowther, P. A.

    An overview of the known Wolf-Rayet (WR) population of the Milky Way is presented, including a brief overview of historical catalogues and recent advances based on infrared photometric and spectroscopic observations resulting in the current census of 642 (vl.13 online catalogue). The observed distribution of WR stars is considered with respect to known star clusters, given that ≤20% of WR stars in the disk are located in clusters. WN stars outnumber WC stars at all galactocentric radii, while early-type WC stars are strongly biased against the inner Milky Way. Finally, recent estimates of the global WR population in the Milky Way are reassessed, with 1,200±100 estimated, such that the current census may be 50% complete. A characteristic WR lifetime of 0.25 Myr is inferred for an initial mass threshold of 25 M⊙.

  11. Evolutionary pattern of improved 1-mile running performance.

    PubMed

    Foster, Carl; de Koning, Jos J; Thiel, Christian

    2014-07-01

    The official world records (WR) for the 1-mile run for men (3:43.13) and for women (4:12.58) have improved 12.2% and 32.3%, respectively, since the first WR recognized by the International Association of Athletics Federations. Previous observations have suggested that the pacing pattern for successive laps is characteristically faster-slower-slowest-faster. However, modeling studies have suggested that uneven energy-output distribution, particularly a high velocity at the end of the race, is essentially wasted kinetic energy that could have been used to finish sooner. Here the authors report that further analysis of the pacing pattern in 32 men's WR races is characterized by a progressive reduction in the within-lap variation of pace, suggesting that improving the WR in the 1-mile run is as much about how energetic resources are managed as about the capacity of the athletes performing the race. In the women's WR races, the pattern of lap times has changed little, probably secondary to a lack of depth in the women's fields. Contemporary WR performances have been achieved a coefficient of variation of lap times on the order of 1.5-3.0%. Reasonable projection suggests that the WR is overdue for improving and may require lap times with a coefficient of variation of ~1%.

  12. O2 uptake kinetics during exercise at peak O2 uptake.

    PubMed

    Scheuermann, Barry W; Barstow, Thomas J

    2003-11-01

    Compared with moderate- and heavy-intensity exercise, the adjustment of O2 uptake (VO2) to exercise intensities that elicit peak VO2 has received relatively little attention. This study examined the VO2 response of 21 young, healthy subjects (25 +/- 6 yr; mean +/- SD) during cycle ergometer exercise to step transitions in work rate (WR) corresponding to 90, 100, and 110% of the peak WR achieved during a preliminary ramp protocol (15-30 W/min). Gas exchange was measured breath by breath and interpolated to 1-s values. VO2 kinetics were determined by use of a two- or three-component exponential model to isolate the time constant (tau2) as representative of VO2 kinetics and the amplitude (Amp) of the primary fast component independent of the appearance of any VO2 slow component. No difference in VO2 kinetics was observed between WRs (tau90 = 24.7 +/- 9.0; tau100 = 22.8 +/- 6.7; tau110 = 21.5 +/- 9.2 s, where subscripts denote percent of peak WR; P > 0.05); nor in a subgroup of eight subjects was tau2 different from the value for moderate-intensity ( 0.05). As expected, the Amp increased with increasing WRs (Amp90 = 2,089 +/- 548; Amp100 = 2,165 +/- 517; Amp110 = 2,225 +/- 559 ml/min; Amp90 vs. Amp110, P < 0.05). However, the gain (G) of the VO2 response (deltaVO2/deltaWR) decreased with increasing WRs (G90 = 8.5 +/- 0.6; G100 = 7.9 +/- 0.6; G110 = 7.3 +/- 0.6 ml.min-1.W-1; P < 0.05). The Amp of the primary component approximated 85, 88, and 89% of peak Vo2 during 90, 100, and 110% WR transitions, respectively. The results of the present study demonstrate that, compared with moderate- and heavy-intensity exercise, the gain of the Vo2 response (as deltaVO2/DeltaWR) is reduced for exercise transitions in the severe-intensity domain, but the approach to this gain is well described by a common time constant that is invariant across work intensities. The lower deltaVO2/deltaWR may be due to an insufficient adjustment of

  13. Internal jugular vein blood flow in multiple sclerosis patients and matched controls.

    PubMed

    Mancini, Marcello; Lanzillo, Roberta; Liuzzi, Raffaele; Di Donato, Orlando; Ragucci, Monica; Monti, Serena; Salvatore, Elena; Morra, Vincenzo Brescia; Salvatore, Marco

    2014-01-01

    The aim of the study was to investigate the Internal Jugular Veins dynamics using contrast enhanced ultrasonography in Multiple Sclerosis patients, clinically isolated syndrome patients and healthy controls. Contrast enhanced ultrasonography imaging of the Internal Jugular Vein was performed in fifty-eight patients with Multiple Sclerosis, seven clinically isolated syndrome patients and in thirteen healthy controls. Time-intensity curves were quantified using a semi-automated method and compared with clinical disease outcomes. Wash-out parameters were calculated and six Time-intensity curves shapes were created. Significantly reduction of wash-out rate in Internal Jugular Veins was detected in Multiple Sclerosis patients compared to healthy controls [22.2% (2.7%-65.9%) vs. 33.4% (16.2%-76.8%); P<0.005]. Internal Jugular Vein enhancement was heterogeneous in patients with Multiple Sclerosis and consisted of slow wash-out Time-intensity curves shapes, compared with almost only one type of Time-intensity curves shape in control subjects that correspond to fast enhancement and fast wash-out. The vein wash-in parameters were similar in Multiple Sclerosis group compared with controls. A significant correlation was found between Internal Jugular Vein wash-out and level of disability (R =  -0.402, p<0.05). Contrast enhanced ultrasonography of the Internal Jugular Vein with time intensity curve analysis revealed alterations of cerebral venous outflow in Multiple Sclerosis patients, however mechanisms that determine this condition remains unclear.

  14. Brown rice and retrograded brown rice alleviate inflammatory response in dextran sulfate sodium (DSS)-induced colitis mice.

    PubMed

    Praengam, Kemika; Sahasakul, Yuraporn; Kupradinun, Piengchai; Sakarin, Siriwan; Sanitchua, Wanwisa; Rungsipipat, Anudep; Rattanapinyopituk, Kasem; Angkasekwinai, Pornpimon; Changsri, Khaimuk; Mhuantong, Wuttichai; Tangphatsornruang, Sithichoke; Tuntipopipat, Siriporn

    2017-12-13

    The present study was aimed to investigate the impacts of brown rice (BR) and retrograded brown rice (R-BR) consumption on colonic health and gut microbiota in dextran sulfate sodium (DSS) induced colitis mice. Thirty two female C57Bl/6Mlac mice were fed with modified AIN 93G diets by replacing cornstarch in the original composition with white rice (WR), BR and R-BR powder. The mice were divided into 4 groups and fed with the following experimental diets for 4 weeks: (1) negative control (WR: diet with WR), (2) positive control (DSS_WR: DSS and diet with WR), (3) DSS_BR: DSS and diet with BR, and (4) DSS_R-BR: DSS and diet with R-BR. BR and R-BR had a greater content of fat, dietary fiber, GABA, γ-oryzanol, γ-tocotrienol, ferulic acid and p-coumaric acid than WR (p < 0.05). No significant difference in the level of these bioactive compounds was noted between BR and R-BR. Nevertheless, R-BR had a 1.8 fold resistant starch (RS) content of BR (p < 0.05). The DSS_BR and DSS_R-BR groups showed a lower ratio of colonic weight to length, and a lower content of iNOS, COX-2, MPO, IL-6 and INF-γ in colonic homogenates than the DSS_WR group. However, the DSS treated mice fed with the R-BR diet had significantly milder histopathological inflammatory injury and lower colonic iNOS expression than the DSS_BR and DSS_WR groups. The percentage of mesenteric regulatory T cells significantly increased in the DSS_R-BR group compared to that in the DSS_WR group. The DSS treated mice fed with the R-BR diet showed a significant increase in cecal bacterial diversity and abundance of genera Prevotella, Ruminococcus, Dorea, Coprococcus and Dehalobacterium but a significant decrease in pathogenic bacteria including Bacteroides and Enterococcus compared to the DSS_WR group. Thus, the present data indicate that BR and R-BR ameliorate colonic inflammation in experimental colitis induced by DSS in mice by suppressing inflammatory mediators and modulating regulatory T cell responses as well as

  15. Fermi-LAT upper limits on gamma-ray emission from colliding wind binaries

    DOE PAGES

    Werner, Michael; Reimer, O.; Reimer, A.; ...

    2013-07-09

    Here, colliding wind binaries (CWBs) are thought to give rise to a plethora of physical processes including acceleration and interaction of relativistic particles. Observation of synchrotron radiation in the radio band confirms there is a relativistic electron population in CWBs. Accordingly, CWBs have been suspected sources of high-energy γ-ray emission since the COS-B era. Theoretical models exist that characterize the underlying physical processes leading to particle acceleration and quantitatively predict the non-thermal energy emission observable at Earth. Furthermore, we strive to find evidence of γ-ray emission from a sample of seven CWB systems: WR 11, WR 70, WR 125, WRmore » 137, WR 140, WR 146, and WR 147. Theoretical modelling identified these systems as the most favourable candidates for emitting γ-rays. We make a comparison with existing γ-ray flux predictions and investigate possible constraints. We used 24 months of data from the Large Area Telescope (LAT) on-board the Fermi Gamma Ray Space Telescope to perform a dedicated likelihood analysis of CWBs in the LAT energy range. As a result, we find no evidence of γ-ray emission from any of the studied CWB systems and determine corresponding flux upper limits. For some CWBs the interplay of orbital and stellar parameters renders the Fermi-LAT data not sensitive enough to constrain the parameter space of the emission models. In the cases of WR140 and WR147, the Fermi -LAT upper limits appear to rule out some model predictions entirely and constrain theoretical models over a significant parameter space. A comparison of our findings to the CWB η Car is made.« less

  16. Comparison of the Impact of the Arctic Oscillation and East Atlantic - West Russia Teleconnection on Interannual Variation in East Asian Winter Temperatures and Monsoon

    NASA Technical Reports Server (NTRS)

    Lim, Young-Kwon; Kim, Hae-Dong

    2014-01-01

    The large-scale impacts of the Arctic Oscillation (AO) and the East Atlantic/West Russia (EA/WR) teleconnection on the East Asian winter climate anomalies are compared for the past 34 winters focusing on 1) interannual monthly to seasonal temperature variability, 2) East Asian winter monsoon (EAWM), and 3) the Siberian high (SH) and cold surge. Regression analysis reveals warming by AO and EA/WR over mid-latitude East Asia during their positive phase and vice versa. The EA/WR impact is found to be comparable to the AO impact in affecting the East Asian temperature and monsoon. For example, warm (cold) months over mid-latitude East Asia during the positive (negative) AO are clearly seen when the AO and EA/WR are in the same phase. Near zero correlation is found between temperature and the AO phase when both teleconnections are in an opposite phase. The well-known negative relationship between SH and the AO phase is observed significantly more often when the AO is in the same phase with the EA/WR. Also, the indices of EAWM, cold surge, and SH are found to be more highly negative-correlated with the EA/WR rather than with the AO. The advective temperature change and associated circulation demonstrate that the anomalous large-scale field including the SH over the mid-latitude Asian inland is better represented by the EA/WR, influencing the East Asian winter climates. These results suggest that the impact of EA/WR should be considered more important than previously thought for a better understanding of East Asian winter temperature and monsoon variability.

  17. Insoluble fiber is a major constituent responsible for lowering the post-prandial blood glucose concentration in the pre-germinated brown rice.

    PubMed

    Seki, Taiichiro; Nagase, Ryohei; Torimitsu, Mariko; Yanagi, Megumi; Ito, Yukihiko; Kise, Mitsuo; Mizukuchi, Aya; Fujimura, Naoko; Hayamizu, Kohusuke; Ariga, Toyohiko

    2005-08-01

    The intake of pre-germinated brown rice (PR) instead of white rice (WR) ameliorates the hyperglycemia. To clarify the mechanism(s) to decrease the post-prandial blood glucose concentration, the effect of water-soluble/oil-soluble fraction-depleted PR bran (termed as "DB"; which is destarched and defatted PR bran) on post-prandial blood glucose was compared with that of full-fat PR bran (PB) or WR. The test diets, WR diet, PB diet and DB diet which are containing identical amount of available carbohydrate (1.5 g) were fed to Wistar strain rats. Post-prandial blood glucose concentration and incremental area under the curve (IAUC) for DB diet were lower than those for WR diet, and there was no difference between the DB diet and PB diet. Changes in plasma insulin concentration and the IAUC obtained also revealed the same tendency as those observed in blood glucose concentration. These results indicate that the blood glucose-lowering effect of PB diet may be derived from the properties of PB involving substantially higher content of dietary fiber than WR, and that the potential benefit of intake of PR instead of WR in the prevention of diabetic vascular complications.

  18. Effects of repetitive shoulder activity on the subacromial space in manual wheelchair users.

    PubMed

    Lin, Yen-Sheng; Boninger, Michael; Worobey, Lynn; Farrokhi, Shawn; Koontz, Alicia

    2014-01-01

    This study investigated (1) the effect of repetitive weight-relief raises (WR) and shoulder external rotation (ER) on the acromiohumeral distance (AHD) among manual wheelchair users (MWUs) and (2) the relationship between shoulder pain, subject characteristics, and AHD changes. Twenty-three MWUs underwent ultrasound imaging of the nondominant shoulder in an unloaded baseline position and while holding a WR position before and after the WR/ER tasks. Paired t-tests and Spearman correlational analysis were used to assess differences in the AHD before and after each task and the relationships between pain, subject characteristics, and the AHD measures. A significant reduction in the subacromial space (P<0.01) occurred when subjects performed a WR position compared to baseline. Individuals with increased years of disability had greater AHD percentage narrowing after WR (P=0.008). Increased shoulder pain was associated with AHD percentage narrowing after ER (P≤0.007). The results support clinical practice guidelines that recommend MWUs limit WR to preserve shoulder function. The isolated repetitive shoulder activity did not contribute to the changes of subacromial space in MWUs. The ultrasonographic measurement of the AHD may be a target for identifying future interventions that prevent pain.

  19. Effects of Repetitive Shoulder Activity on the Subacromial Space in Manual Wheelchair Users

    PubMed Central

    Lin, Yen-Sheng; Boninger, Michael; Worobey, Lynn; Farrokhi, Shawn; Koontz, Alicia

    2014-01-01

    This study investigated (1) the effect of repetitive weight-relief raises (WR) and shoulder external rotation (ER) on the acromiohumeral distance (AHD) among manual wheelchair users (MWUs) and (2) the relationship between shoulder pain, subject characteristics, and AHD changes. Twenty-three MWUs underwent ultrasound imaging of the nondominant shoulder in an unloaded baseline position and while holding a WR position before and after the WR/ER tasks. Paired t-tests and Spearman correlational analysis were used to assess differences in the AHD before and after each task and the relationships between pain, subject characteristics, and the AHD measures. A significant reduction in the subacromial space (P < 0.01) occurred when subjects performed a WR position compared to baseline. Individuals with increased years of disability had greater AHD percentage narrowing after WR (P = 0.008). Increased shoulder pain was associated with AHD percentage narrowing after ER (P ≤ 0.007). The results support clinical practice guidelines that recommend MWUs limit WR to preserve shoulder function. The isolated repetitive shoulder activity did not contribute to the changes of subacromial space in MWUs. The ultrasonographic measurement of the AHD may be a target for identifying future interventions that prevent pain. PMID:25215283

  20. Basal Serum Calcitonin, After Calcium Stimulation, and in the Needle Washout of Patients with Thyroid Nodules and Mild or Moderate Basal Hypercalcitoninemia.

    PubMed

    Rosario, P W; Calsolari, M R

    2017-02-01

    This prospective study evaluated the concentrations of basal serum calcitonin (Ctn), Ctn after stimulation with calcium, and Ctn in the needle washout (FNA-Ctn) as predictors of sporadic medullary thyroid carcinoma (MTC) in patients with thyroid nodules and basal Ctn between 10 and 100 pg/ml. Forty-one patients were included in the study. MTC was diagnosed in only 6 patients (14.6%). None of the patients with basal Ctn≤24.6 pg/ml (n=26) or stimulated Ctn≤186.5 pg/ml (n=21) had MTC. All patients without MTC had basal Ctn<47 pg/ml and stimulated Ctn<655.2 pg/ml. Among patients with basal Ctn between 24.6 and 47 pg/ml (n=12), 3 (25%) had MTC. Among patients with stimulated Ctn between 186.5 and 655.2 pg/ml (n=18), 4 (22.2%) had MTC. FNA-Ctn distinguished nodules that were MTC (n=6) from those that were not (n=60), without overlapping results. In the calcium stimulation test, 19 patients (46.3%) reported some adverse effect, but none of them was severe or required specific treatment. Our results highlight that in patients without a history suspicious for MTC, mild or moderate basal hypercalcitoninemia should not establish the diagnosis of this tumor. Depending on the concentration found, basal Ctn should be sufficient to define patient management. In doubtful cases, FNA-Ctn seems to be the best diagnostic test. Calcium stimulation testing was safe, but more studies are needed to determine the Ctn cutoff after stimulation with calcium. © Georg Thieme Verlag KG Stuttgart · New York.

  1. Forming short-period Wolf-Rayet X-ray binaries and double black holes through stable mass transfer

    NASA Astrophysics Data System (ADS)

    van den Heuvel, E. P. J.; Portegies Zwart, S. F.; de Mink, S. E.

    2017-11-01

    We show that black hole high-mass X-ray binaries (HMXBs) with O- or B-type donor stars and relatively short orbital periods, of order one week to several months may survive spiral-in, to then form Wolf-Rayet (WR) X-ray binaries with orbital periods of order a day to a few days; while in systems where the compact star is a neutron star, HMXBs with these orbital periods never survive spiral-in. We therefore predict that WR X-ray binaries can only harbour black holes. The reason why black hole HMXBs with these orbital periods may survive spiral-in is: the combination of a radiative envelope of the donor star and a high mass of the compact star. In this case, when the donor begins to overflow its Roche lobe, the systems are able to spiral in slowly with stable Roche lobe overflow, as is shown by the system SS433. In this case, the transferred mass is ejected from the vicinity of the compact star (so-called isotropic re-emission mass-loss mode, or SS433-like mass-loss), leading to gradual spiral-in. If the mass ratio of donor and black hole is ≳3.5, these systems will go into common-envelope evolution and are less likely to survive. If they survive, they produce WR X-ray binaries with orbital periods of a few hours to one day. Several of the well-known WR+O binaries in our Galaxy and the Magellanic Clouds, with orbital periods in the range between a week and several months, are expected to evolve into close WR-black hole binaries, which may later produce close double black holes. The galactic formation rate of double black holes resulting from such systems is still uncertain, as it depends on several poorly known factors in this evolutionary picture. It might possibly be as high as ˜10-5 yr-1.

  2. A Military Vignette for a Heterogeneous Data Proximity Tool (HDPT) Study

    DTIC Science & Technology

    2013-06-01

    religion) member of HDPT binary Mild theology = Mld; radical theology = Rad Skill HDPT nominal Photography = PH; writing = WR; electrical = EL...photography (PH), writing (WR), driving (DR), computer (CO), electrical (EL), and financial (FI). There are no embedded trends within skill values...Still Serving Skill: WR ( Writing ) Address: HAV (Hanover Village) Education Level: High Ridha Mahdi El-Mofty (S7) Tribal Affiliation is Pastu Criminal

  3. Drug Evaluation in the Plasmodium Falciparum - Aotus Model

    DTIC Science & Technology

    1986-10-01

    blood schizonticidal/curative activity of experimental antimalarial drugs. WR 245082, an acridineainine, at similar doses cured infections of chloroquine ...Guinea - Chesson strain). The curative activity of WR 245082, an acridineamine, for chloroquine - sensitive and chloroquine -resistant strains of P...antimalarial activity of two analogues of the amino acid histidine was assessed against infections of the Uganda Palo Alto strain. WR 251853, 2-fluoro-l

  4. The Long-Lasting Enhancing Effect of Distigmine on Acetylcholine-Induced Contraction of Guinea Pig Detrusor Smooth Muscle Correlates with Its Anticholinesterase Activity.

    PubMed

    Obara, Keisuke; Ogawa, Tsukasa; Chino, Daisuke; Tanaka, Yoshio

    2017-01-01

    Distigmine bromide (distigmine), a reversible, long-lasting cholinesterase (ChE) inhibitor, is used for the treatment of underactive bladder in Japan and has been shown to potentiate urinary bladder (UB) contractility. We studied the duration of distigmine's potentiating effects on acetylcholine (ACh)-induced UB contraction and its inhibitory effects on ChE activity, and compared that with those of other ChE inhibitors (neostigmine, pyridostigmine, and ambenonium). The duration of potentiating/inhibitory effects of ChE inhibitors, including distigmine, on ACh-induced guinea pig UB contraction/ChE activity was evaluated for 12 h following washout. Dissociation rate constants (k) of the inhibitors were also tentatively calculated based on the time courses of their ChE inhibitory effects. The potentiating effect of distigmine (10 -6  M) on ACh-induced UB contraction and its inhibitory effect on ChE activity were significantly sustained 12 h after washout. The potentiating effect of other ChE inhibitors on ACh-induced UB contraction, however, was sustained only until 3 h after washout. The ChE inhibitory effects of these inhibitors dissipated in a time-dependent manner after washout, with more than 75% of ChE activity restored by 4 h after washout. The k values of ChE inhibitors approached 0.50 h -1 , except for distigmine, where k could not be determined. Compared with that of other ChE inhibitors, the potentiating effect of distigmine on UB contractile function was significantly more sustainable following washout, which was likely associated with its corresponding long-lasting ChE inhibitory effect. Distigmine may associate more strongly with UB ChE than other ChE inhibitors, which would partly explain its sustained effects.

  5. Plaster core washout tool

    NASA Technical Reports Server (NTRS)

    Heisman, R. M.; Keir, A. R.; Teramura, K.

    1977-01-01

    Tool powered by pressurized water or air removes water soluble plaster lining from Kevlar/epoxy duct. Rotating plastic cutterhead with sealed end fitting connects flexible shaft that allows tool to be used with curved ducts.

  6. Effect of early thermal experience on pituitary-gonadal axis in female rats.

    PubMed

    Kurowicka, Beata; Gajewska, Alina; Franczak, Anita

    2006-03-01

    The reproductive system fully develops during postnatal stages of life, and as such it may be susceptible to environmental cues such as high temperature. Thus, the purpose of the study was to compare how exposure to 34 degrees Celsius ambient temperature affects pituitary-gonadal axis of immature and adult female rats. Three groups of females at proestrous or metaestrous (n=38) were used in the study. The females were housed in ambient temperature of 34 degrees Celsius (WR group, n=10) or room temperature (CR group, n=16) from birth to adulthood. The females from the third group were acclimated to 34 degrees Celsius as adults (WA group, n=12). In the WR group the onset of puberty was delayed in comparison to the CR group. The plasma PRL level was lower during proestrous and higher during metaestrous in the WR group compared to the CR group. During metaestrous, lower FSH and higher progesterone (P(4)) plasma concentrations were found in the WR females. No changes in LH and oestradiol (E(2)) plasma concentrations were demonstrated. Higher in vitro E(2) and lower P(4) secretions under FSH stimulation were observed in the WR follicles compared to those of the CR group. The WR group also demonstrated higher basal and LH-stimulated luteal in vitro secretion of P(4) than controls. Plasma LH and FSH concentrations during metaestrous were higher in WA females than in the WR group, but PRL level was lower. Follicles of the WA group were unresponsive to FSH with respect to steroid secretion. In addition, LH stimulated luteal E(2) secretion in this group. P(4) release by luteal cells was lower in the WA than in the WR group. We concluded that WR females differ from WA in reproductive system adjustments to rearing temperature and that early thermal experience is more effective in antagonizing the effect of high temperature than acclimation of adult females.

  7. Conceptual Design of a Stand-Off Weapon for Maritime Patrol Aircraft

    DTIC Science & Technology

    1988-09-01

    19:p. 98) c feet in front of the CG position and the rate gyro is placed such that its position does not coincide with a vibration node. [Ref. 19:p...Davis, W.R., Surpressing the Infrared Signature of Marine Gas Turbines, paper presented at the Gas Turbine and Aeroengine Congress and Exposition

  8. Effects of dietary carbohydrate replaced with wild rice (Zizania latifolia (Griseb) Turcz) on insulin resistance in rats fed with a high-fat/cholesterol diet.

    PubMed

    Han, Shufen; Zhang, Hong; Qin, Liqiang; Zhai, Chengkai

    2013-02-15

    Wild rice (WR) is a very nutritious grain that has been used to treat diabetes in Chinese medicinal practice. City diet (CD) is based on the diet consumed by Asian area residents in modern society, which is rich in saturated fats, cholesterol and carbohydrates. The present study was aimed at evaluating the effects of replacing white rice and processed wheat starch of CD with WR as the chief source of dietary carbohydrates on insulin resistance in rats fed with a high-fat/cholesterol diet. Except the rats of the low-fat (LF) diet group, the rats of the other three groups, including to high-fat/cholesterol (HFC) diet, CD and WR diet, were fed with high-fat/cholesterol diets for eight weeks. The rats fed with CD exhibited higher weight gain and lower insulin sensitivity compared to the rats consuming a HFC diet. However, WR suppressed high-fat/cholesterol diet-induced insulin resistance. WR decreased liver homogenate triglyceride and free fatty acids levels, raised serum adiponectin concentration and reduced serum lipocalin-2 and visfatin concentrations. In addition, the WR diet potently augmented the relative expressions of adiponectin receptor 2, peroxisome proliferator-activated receptors, alpha and gamma, and abated relative expressions of leptin and lipocalin-2 in the tissues of interest. These findings indicate that WR is effective in ameliorating abnormal glucose metabolism and insulin resistance in rats, even when the diet consumed is high in fat and cholesterol.

  9. Using rainfall radar data to improve interpolated maps of dose rate in the Netherlands.

    PubMed

    Hiemstra, Paul H; Pebesma, Edzer J; Heuvelink, Gerard B M; Twenhöfel, Chris J W

    2010-12-01

    The radiation monitoring network in the Netherlands is designed to detect and track increased radiation levels, dose rate more specifically, in 10-minute intervals. The network consists of 153 monitoring stations. Washout of radon progeny by rainfall is the most important cause of natural variations in dose rate. The increase in dose rate at a given time is a function of the amount of progeny decaying, which in turn is a balance between deposition of progeny by rainfall and radioactive decay. The increase in progeny is closely related to average rainfall intensity over the last 2.5h. We included decay of progeny by using weighted averaged rainfall intensity, where the weight decreases back in time. The decrease in weight is related to the half-life of radon progeny. In this paper we show for a rainstorm on the 20th of July 2007 that weighted averaged rainfall intensity estimated from rainfall radar images, collected every 5min, performs much better as a predictor of increases in dose rate than using the non-averaged rainfall intensity. In addition, we show through cross-validation that including weighted averaged rainfall intensity in an interpolated map using universal kriging (UK) does not necessarily lead to a more accurate map. This might be attributed to the high density of monitoring stations in comparison to the spatial extent of a typical rain event. Reducing the network density improved the accuracy of the map when universal kriging was used instead of ordinary kriging (no trend). Consequently, in a less dense network the positive influence of including a trend is likely to increase. Furthermore, we suspect that UK better reproduces the sharp boundaries present in rainfall maps, but that the lack of short-distance monitoring station pairs prevents cross-validation from revealing this effect. Copyright © 2010 Elsevier B.V. All rights reserved.

  10. Organic carbon, water repellency and soil stability to slaking at aggregate and intra-aggregate scales

    NASA Astrophysics Data System (ADS)

    Jordán López, Antonio; García-Moreno, Jorge; Gordillo-Rivero, Ángel J.; Zavala, Lorena M.; Cerdà, Artemi; Alanís, Nancy; Jiménez-Compán, Elizabeth

    2015-04-01

    Water repellency (WR) is a property of some soils that inhibits or delays water infiltration between a few seconds and days or weeks. Inhibited or delayed infiltration contributes to ponding and increases runoff flow generation, often increasing soil erosion risk. In water-repellent soils, water infiltrates preferentially through cracks or macropores, causing irregular soil wetting patterns, the development of preferential flow paths and accelerated leaching of nutrients. Although low inputs of hydrophobic organic substances and high mineralization rates lead to low degrees of WR in cropped soils, it has been reported that conservative agricultural practices may induce soil WR. Although there are many studies at catchment, slope or plot scales very few studies have been carried out at particle or aggregate scale. Intra-aggregate heterogeneity of physical, biological and chemical properties conditions the transport of substances, microbial activity and biochemical processes, including changes in the amount, distribution and chemical properties of organic matter. Some authors have reported positive relationships between soil WR and aggregate stability, since it may delay the entry of water into aggregates, increase structural stability and contribute to reduce soil erosion risk. Organic C (OC) content, aggregate stability and WR are therefore strongly related parameters. In the case of agricultural soils, where both the type of management as crops can influence all these parameters, it is important to evaluate the interactions among them and their consequences. Studies focused on the intra-aggregate distribution of OC and WR are necessary to shed light on the soil processes at a detailed scale. It is extremely important to understand how the spatial distribution of OC in soil aggregates can protect against rapid water entry and help stabilize larger structural units or lead to preferential flow. The objectives of this research are to study [i] the OC content and the

  11. Number of Players and Relative Pitch Area per Player: Comparing Their Influence on Heart Rate and Physical Demands in Under-12 and Under-13 Football Players.

    PubMed

    Castellano, Julen; Puente, Asier; Echeazarra, Ibon; Usabiaga, Oidui; Casamichana, David

    2016-01-01

    The aim of the present study is to analyse the influence of different large-sided games (LSGs) on the physical and physiological variables in under-12s (U12) and -13s (U13) soccer players. The effects of the combination of different number of players per team, 7, 9, and 11 (P7, P9, and P11, respectively) with three relative pitch areas, 100, 200, and 300 m(2) (A100, A200, and A300, respectively), were analysed in this study. The variables analysed were: 1) global indicator such as total distance (TD); work:rest ratio (W:R); player-load (PL) and maximal speed (Vmax); 2) heart rate (HR) mean and time spent in different intensity zones of HR (<75%, 75-84%, 84-90% and >90%), and; 3) five absolute (<8, 8-13, 13-16 and >16 Km h(-1)) and three relative speed categories (<40%, 40-60% and >60% Vmax). The results support the theory that a change in format (player number and pitch dimensions) affects no similarly in the two players categories. Although it can seem that U13 players are more demanded in this kind of LSG, when the work load is assessed from a relative point of view, great pitch dimensions and/or high number of player per team are involved in the training task to the U12 players. The results of this study could alert to the coaches to avoid some types of LSGs for the U12 players such as: P11 played in A100, A200 or A300, P9 played in A200 or A300 and P7 played in A300 due to that U13>U12 in several physical and physiological variables (W:R, time spent in 84-90%HRmax, distance in 8-13 and 13-16 Km h(-1) and time spent in 40-60%Vmax). These results may help youth soccer coaches to plan the progressive introduction of LSGs so that task demands are adapted to the physiological and physical development of participants.

  12. Semantic organizational strategy predicts verbal memory and remission rate of geriatric depression.

    PubMed

    Morimoto, Sarah Shizuko; Gunning, Faith M; Kanellopoulos, Dora; Murphy, Christopher F; Klimstra, Sibel A; Kelly, Robert E; Alexopoulos, George S

    2012-05-01

    This study tests the hypothesis that the use of semantic organizational strategy during the free-recall phase of a verbal memory task predicts remission of geriatric depression. Sixty-five older patients with major depression participated in a 12-week escitalopram treatment trial. Neuropsychological performance was assessed at baseline after a 2-week drug washout period. The Hopkins Verbal Learning Test-Revised was used to assess verbal learning and memory. Remission was defined as a Hamilton Depression Rating Scale score of ≤ 7 for 2 consecutive weeks and no longer meeting the DSM-IV-TR criteria for major depression. The association between the number of clusters used at the final learning trial (trial 3) and remission was examined using Cox's proportional hazards survival analysis. The relationship between the number of clusters utilized in the final learning trial and the number of words recalled after a 25-min delay was examined in a regression with age and education as covariates. Higher number of clusters utilized predicted remission rates (hazard ratio, 1.26 (95% confidence interval, 1.04-1.54); χ(2)  = 4.23, df = 3, p = 0.04). There was a positive relationship between the total number of clusters used by the end of the third learning trial and the total number of words recalled at the delayed recall trial (F(3,58) = 7.93; p < 0.001). Effective semantic strategy use at baseline on a verbal list learning task by older depressed patients was associated with higher rates of remission with antidepressant treatment. This result provides support for previous findings indicating that measures of executive functioning at baseline are useful in predicting antidepressant response. Copyright © 2011 John Wiley & Sons, Ltd.

  13. Statistical properties of relative weight distributions of four salmonid species and their sampling implications

    USGS Publications Warehouse

    Hyatt, M.W.; Hubert, W.A.

    2001-01-01

    We assessed relative weight (Wr) distributions among 291 samples of stock-to-quality-length brook trout Salvelinus fontinalis, brown trout Salmo trutta, rainbow trout Oncorhynchus mykiss, and cutthroat trout O. clarki from lentic and lotic habitats. Statistics describing Wr sample distributions varied slightly among species and habitat types. The average sample was leptokurtotic and slightly skewed to the right with a standard deviation of about 10, but the shapes of Wr distributions varied widely among samples. Twenty-two percent of the samples had nonnormal distributions, suggesting the need to evaluate sample distributions before applying statistical tests to determine whether assumptions are met. In general, our findings indicate that samples of about 100 stock-to-quality-length fish are needed to obtain confidence interval widths of four Wr units around the mean. Power analysis revealed that samples of about 50 stock-to-quality-length fish are needed to detect a 2% change in mean Wr at a relatively high level of power (beta = 0.01, alpha = 0.05).

  14. Time-resolved comparative metabolomes for Koji fermentation with brown-, white-, and giant embryo-rice.

    PubMed

    Lee, Da Eun; Lee, Sunmin; Singh, Digar; Jang, Eun Seok; Shin, Hye Won; Moon, Byoung Seok; Lee, Choong Hwan

    2017-09-15

    A time-resolved non-targeted metabolomic study towards evaluating the effects of three rice substrate types viz., white rice (WR), giant embryo rice (GER), and brown rice (BR), on Koji fermentation was performed. Notwithstanding the relatively higher proportions of metabolites in unfermented BR (BR 0>WR 0, GER 0), the relative levels of metabolic repertoire in BR Koji were marginally enhanced during 36h fermentation except those for phenolic acids, fatty acids, and vitamins. The WR Koji showed higher levels of lysophospholipids (LysoPC's) and protease-released amino acids (WR 36>GER 36>BR 36). The higher β-glucosidase activity in GER Koji effected the increased levels of sugars and flavonoid aglycons complementing its higher antioxidant activity (GER Koji>BR Koji∼WR Koji). The present study holistically underpins the dynamic metabolomes and enzymatic states during rice Koji fermentation with varying substrate types. The present study finds applications in optimization of commercial Koji production. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. Impotence evaluated by the use of prostaglandin E1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hwang, T.I.; Yang, C.R.; Wang, S.J.

    1989-06-01

    We screened 80 patients at our hospital for the differential diagnosis of impotence using intracavernous injection of prostaglandin E1 (20 micrograms). The rate of positive response was 78.8 per cent (63 patients). Neither systemic reactions nor priapism occurred. However, a considerable incidence (23.8 per cent, 19 of 80 patients) of tolerable injection pain was encountered. The 133-xenon penile washout study was conducted routinely in impotent men for hemodynamic evaluation of penile vascularity. In 80 patients a positive correlation between the response of intracavernous prostaglandin E1 injection and the result of the washout study was found (r equals 0.381, p lessmore » than 0.0002). We selected 14 subjects randomly to receive additional intravenous infusions of prostaglandin E1 (6 ampules, 120 micrograms total) for 3 days, after which another 133-xenon washout study was done. The washout studies before and after intravenous prostaglandin E1 infusion were compared, and 10 patients (71.4 per cent) appeared to obtain improvement in half-time clearance and penile blood flow. However, only 3 patients noticed improvement subjectively. We suggest that prostaglandin E1 could be a desirable alternative for the diagnosis and treatment of impotence.« less

  16. Efficient delivery of cell impermeable phosphopeptides by a cyclic peptide amphiphile containing tryptophan and arginine.

    PubMed

    Nasrolahi Shirazi, Amir; Tiwari, Rakesh Kumar; Oh, Donghoon; Banerjee, Antara; Yadav, Arpita; Parang, Keykavous

    2013-05-06

    Phosphopeptides are valuable reagent probes for studying protein-protein and protein-ligand interactions. The cellular delivery of phosphopeptides is challenging because of the presence of the negatively charged phosphate group. The cellular uptake of a number of fluorescent-labeled phosphopeptides, including F'-GpYLPQTV, F'-NEpYTARQ, F'-AEEEIYGEFEAKKKK, F'-PEpYLGLD, F'-pYVNVQN-NH2, and F'-GpYEEI (F' = fluorescein), was evaluated in the presence or absence of a [WR]4, a cyclic peptide containing alternative arginine (R) and tryptophan (W) residues, in human leukemia cells (CCRF-CEM) after 2 h incubation using flow cytometry. [WR]4 improved significantly the cellular uptake of all phosphopeptides. PEpYLGLD is a sequence that mimics the pTyr1246 of ErbB2 that is responsible for binding to the Chk SH2 domain. The cellular uptake of F'-PEpYLGLD was enhanced dramatically by 27-fold in the presence of [WR]4 and was found to be time-dependent. Confocal microscopy of a mixture of F'-PEpYLGLD and [WR]4 in live cells exhibited intracellular localization and significantly higher cellular uptake compared to that of F'-PEpYLGLD alone. Transmission electron microscopy (TEM) and isothermal calorimetry (ITC) were used to study the interaction of PEpYLGLD and [WR]4. TEM results showed that the mixture of PEpYLGLD and [WR]4 formed noncircular nanosized structures with width and height of 125 and 60 nm, respectively. ITC binding studies confirmed the interaction between [WR]4 and PEpYLGLD. The binding isotherm curves, derived from sequential binding models, showed an exothermic interaction driven by entropy. These studies suggest that amphiphilic peptide [WR]4 can be used as a cellular delivery tool of cell-impermeable negatively charged phosphopeptides.

  17. Seal Technology Development for Advanced Component for Airbreathing Engines

    NASA Technical Reports Server (NTRS)

    Snyder, Philip H.

    2008-01-01

    Key aspects of the design of sealing systems for On Rotor Combustion/Wave Rotor (ORC/WR) systems were addressed. ORC/WR systems generally fit within a broad class of pressure gain Constant Volume Combustors (CVCs) or Pulse Detonation Combustors (PDCs) which are currently being considered for use in many classes of turbine engines for dramatic efficiency improvement. Technology readiness level of this ORC/WR approaches are presently at 2.0. The results of detailed modeling of an ORC/WR system as applied to a regional jet engine application were shown to capture a high degree of pressure gain capabilities. The results of engine cycle analysis indicated the level of specific fuel consumption (SFC) benefits to be 17 percent. The potential losses in pressure gain due to leakage were found to be closely coupled to the wave processes at the rotor endpoints of the ORC/WR system. Extensive investigation into the sealing approaches is reported. Sensitivity studies show that SFC gains of 10 percent remain available even when pressure gain levels are highly penalized. This indicates ORC/WR systems to have a high degree of tolerance to rotor leakage effects but also emphasizes their importance. An engine demonstration of an ORC/WR system is seen as key to progressing the TRL of this technology. An industrial engine was judged to be a highly advantageous platform for demonstration of a first generation ORC/WR system. Prior to such a demonstration, the existing NASA pressure exchanger wave rotor rig was identified as an opportunity to apply both expanded analytical modeling capabilities developed within this program and to identify and fix identified leakage issues existing within this rig. Extensive leakage analysis of the rig was performed and a detailed design of additional sealing strategies for this rig was generated.

  18. Predictors of Success in Bariatric Surgery: the Role of BMI and Pre-operative Comorbidities.

    PubMed

    da Cruz, Magda Rosa Ramos; Branco-Filho, Alcides José; Zaparolli, Marília Rizzon; Wagner, Nathalia Farinha; de Paula Pinto, José Simão; Campos, Antônio Carlos Ligocki; Taconeli, Cesar Augusto

    2018-05-01

    This is a retrospective review of 204 patients who underwent bariatric surgery. The impact of weight regain (WR), pre-operative comorbidities and BMI values on the recurrence of comorbidities was evaluated, and an equation was elaborated to estimate BMI at 5 years of bariatric surgery. Pre-operative data, after 1 year and after 5 years, was collected from the medical records. Descriptive analyses and bivariate hypothesis tests were performed first, and then, a generalised linear regression model with Tweedie distribution was adjusted. The hit rate and the Kendall coefficient of concordance (Kendall's W) of the equation were calculated. At the end, the Mann-Whitney test was performed between the BMI, WR and the presence of comorbidities, after a post-operative period of 5 years. The adjustment of the model resulted in an equation that estimates the mean value of BMI 5 years after surgery. The hit rate was 82.35% and the value of Kendall's W was 0.85 for the equation. It was found that patients with comorbidities presented a higher median WR (10.13%) and a higher mean BMI (30.09 kg/m 2 ) 5 years after the surgery. It is concluded that the equation is useful for estimating the mean BMI at 5 years of surgery and that patients with low pre-operative HDL and folic acid levels, with depression and/or anxiety and a higher BMI, have a higher BMI at 5 years of surgery and higher incidence of comorbid return and dissatisfaction with post-operative results.

  19. Rabbitpox virus and vaccinia virus infection of rabbits as a model for human smallpox.

    PubMed

    Adams, Mathew M; Rice, Amanda D; Moyer, R W

    2007-10-01

    The threat of smallpox release and use as a bioweapon has encouraged the search for new vaccines and antiviral drugs, as well as development of new small-animal models in which their efficacy can be determined. Here, we reinvestigate a rabbit model in which the intradermal infection of rabbits with very low doses of either rabbitpox virus (RPV) or vaccinia virus Western Reserve (VV-WR) recapitulates many of the clinical features of human smallpox. Following intradermal inoculation with RPV, rabbits develop systemic disease characterized by extensive viremia, numerous secondary lesions on the skin and mucocutaneous tissues, severe respiratory disease, death by 9 days postinfection, and, importantly, natural aerosol transmission between animals. Contrary to previous reports, intradermal infection with VV-WR also resulted in a very similar lethal systemic disease in rabbits, again with natural aerosol transmission between animals. When sentinel and index animals were cohoused, transmission rates approached 100% with either virus, with sentinel animals exhibiting a similar, severe disease. Lower rates of transmission were observed when index and sentinel animals were housed in separate cages. Sentinel animals infected with RPV with one exception succumbed to the disease. However, the majority of VV-WR-infected sentinel animals, while becoming seriously ill, survived. Finally, we tested the efficacy of the drug 1-O-hexadecyloxypropyl-cidofovir in the RPV/rabbit model and found that an oral dose of 5 mg/kg twice a day for 5 days beginning 1 day before infection was able to completely protect rabbits from lethal disease.

  20. Blue bubble in Carina

    NASA Image and Video Library

    2016-02-22

    Sparkling at the centre of this beautiful NASA/ESA Hubble Space Telescope image is a Wolf–Rayet star known as WR 31a, located about 30 000 light-years away in the constellation of Carina (The Keel). The distinctive blue bubble appearing to encircle WR 31a, and its uncatalogued stellar sidekick, is a Wolf–Rayet nebula — an interstellar cloud of dust, hydrogen, helium and other gases. Created when speedy stellar winds interact with the outer layers of hydrogen ejected by Wolf–Rayet stars, these nebulae are frequently ring-shaped or spherical. The bubble — estimated to have formed around 20 000 years ago — is expanding at a rate of around 220 000 kilometres per hour! Unfortunately, the lifecycle of a Wolf–Rayet star is only a few hundred thousand years — the blink of an eye in cosmic terms. Despite beginning life with a mass at least 20 times that of the Sun, Wolf–Rayet stars typically lose half their mass in less than 100 000 years. And WR 31a is no exception to this case. It will, therefore, eventually end its life as a spectacular supernova, and the stellar material expelled from its explosion will later nourish a new generation of stars and planets.

  1. VizieR Online Data Catalog: Rotating Wolf-Rayet stars in post RSG/LBV phase (Graefener+, 2012)

    NASA Astrophysics Data System (ADS)

    Graefener, G.; Vink, J. S.; Harries, T. J.; Langer, N.

    2013-01-01

    Wolf-Rayet (WR) stars with fast rotating cores are thought to be the direct progenitors of long-duration gamma-ray bursts (LGRBs). A well accepted evolutionary channel towards LGRBs is chemically-homogeneous evolution at low metallicities, which completely avoids a red supergiant (RSG), or luminous blue variable (LBV) phase. On the other hand, strong absorption features with velocities of several hundred km/s have been found in some LGRB afterglow spectra (GRB 020813 and GRB 021004), which have been attributed to dense circumstellar (CS) material that has been ejected in a previous RSG or LBV phase, and is interacting with a fast WR-type stellar wind. Here we investigate the properties of Galactic WR stars and their environment to identify similar evolutionary channels that may lead to the formation of LGRBs. We compile available information on the spectropolarimetric properties of 29 WR stars, the presence of CS ejecta for 172 WR stars, and the CS velocities in the environment of 34 WR stars in the Galaxy. We use linear line-depolarization as an indicator of rotation, nebular morphology as an indicator of stellar ejecta, and velocity patterns in UV absorption features as an indicator of increased velocities in the CS environment. (2 data files).

  2. Reduction of extinction and reinstatement of cocaine seeking by wheel running in female rats.

    PubMed

    Zlebnik, Natalie E; Anker, Justin J; Gliddon, Luke A; Carroll, Marilyn E

    2010-03-01

    Previous work has shown that wheel running reduced the maintenance of cocaine self-administration in rats. In the present study, the effect of wheel running on extinction and reinstatement of cocaine seeking was examined. Female rats were trained to run in a wheel during 6-h sessions, and they were then catheterized and placed in an operant conditioning chamber where they did not have access to the wheel but were allowed to self-administer iv cocaine. Subsequently, rats were divided into four groups and were tested on the extinction and reinstatement of cocaine seeking while they had varying access to a wheel in an adjoining compartment. The four groups were assigned to the following wheel access conditions: (1) wheel running during extinction and reinstatement (WER), (2) wheel running during extinction and a locked wheel during reinstatement (WE), (3) locked wheel during extinction and wheel running during reinstatement (WR), and (4) locked wheel during extinction and reinstatement (WL). WE and WR were retested later to examine the effect of one session of wheel access on cocaine-primed reinstatement. There were no group differences in wheel revolutions, in rate of acquisition of cocaine self-administration, or in responding during maintenance when there was no wheel access. However, during extinction, WE and WER responded less than WR and WL. WR and WER had lower cocaine-primed reinstatement than WE and WL. One session of wheel exposure in WE also suppressed cocaine-primed reinstatement. Wheel running immediately and effectively reduced cocaine-seeking behavior, but concurrent access to running was necessary. Thus, exercise is a useful and self-sustaining intervention to reduce cocaine-seeking behavior.

  3. Altered metabolism of orally administered loxoprofen in human subjects after an oral administration of loxoprofen for three consecutive days followed by a seven-day washout.

    PubMed

    Kim, In-Wha; Chung, Suk-Jae; Shim, Chang-Koo

    2002-04-01

    The effect of pretreatment (i.e., oral administration of loxoprofen for 3 consecutive days followed by a 7-day washout) on the pharmacokinetics and metabolism of the drug was studied in humans. In a control study, a Loxonin tablet (60 mg as loxoprofen anhydrous) was administered orally to 6 healthy male Korean subjects. In a pretreatment study, a Loxonin tablet was administered orally to the subjects once daily for 3 consecutive days. On the 10(th) day, a Loxonin tablet was administered orally to the subjects, and the concentrations of loxoprofen and the trans- and cis-alcohol metabolites in the plasma and urine were measured as a function of time. Using this pretreatment, the area under the curve (AUC) of the trans-alcohol metabolite of loxoprofen in the plasma, but not those of loxoprofen and the cis-alcohol metabolite, was increased (1.5-fold, p < 0.05), leading to increased contribution of the trans-alcohol metabolite to the total urinary recovery of loxoprofen (1.3-fold, p < 0.05). The urinary recovery of total metabolites, which was largely (> 90%) comprised of conjugate metabolites, was also increased as a result of the pretreatment (1.5-fold, p < 0.05). These results indicate that stereoselective reduction to trans-alcohol metabolites as well as the phase II metabolism of loxoprofen may be increased by such a pretreatment in human subjects. Copyright 2002 Wiley-Liss, Inc. and the American Pharmaceutical Association J Pharm Sci 91:973-979, 2002

  4. Differential effects of simple vs. complex carbohydrates on VLDL secretion rates and HDL metabolism in the guinea pig.

    PubMed

    Fernandez, M L; Abdel-Fattah, G; McNamara, D J

    1995-04-28

    Guinea pigs were fed isocaloric diets containing 52% (w/w) carbohydrate, either sucrose or starch, to investigate effects of simple vs. complex carbohydrates on plasma VLDL and HDL metabolism. Plasma cholesterol concentrations were not different between dietary groups while plasma triacylglycerol (TAG) and VLDL cholesterol levels were significantly increased in animals fed the sucrose diet (P < 0.05). Hepatic VLDL TAG secretion rates measured following intravenous injection of Triton WR-1339 were not affected by carbohydrate type whereas the rate of apo B secretion was 1.9-fold higher in sucrose fed animals (P < 0.02). Nascent VLDL from the sucrose group contained less TAG per apo B suggesting that the higher plasma TAG in animals fed simple carbohydrates results from increased secretion of VLDL particles with lower TAG content. Sucrose fed animals exhibited higher concentrations of hepatic free cholesterol (P < 0.01) while hepatic TAG levels and acyl CoA:cholesterol acyltransferase (ACAT) activity were not different between groups. Plasma HDL cholesterol concentrations and composition, and plasma lecithin cholesterol acyltransferase (LCAT) activity were not affected by diet yet there was a positive correlation between HDL cholesteryl ester content and LCAT activities (r = 0.70, P < 0.05). Hepatic membranes from the sucrose group had a higher hepatic HDL binding protein number (Bmax) with no changes in the dissociation constant (Kd). These results suggest that at the same carbohydrate energy intake, simple sugars induce modest changes in HDL metabolism while VLDL metabolism is affected at multiple sites, as indicated by the higher concentrations of hepatic cholesterol, dissociation in the synthesis rates of VLDL components, and compositional changes in nascent and mature VLDL.

  5. Suboptimal Weight Loss and Weight Regain after Gastric Bypass Surgery-Postoperative Status of Energy Intake, Eating Behavior, Physical Activity, and Psychometrics.

    PubMed

    Amundsen, Tina; Strømmen, Magnus; Martins, Catia

    2017-05-01

    Suboptimal weight loss (SWL) and weight regain (WR) after gastric bypass surgery (GB) remains poorly understood. This study aims to compare GB patients experiencing SWL or significant WR (SigWR) with successful controls, regarding postoperative food intake, eating behavior, physical activity (PA), and psychometrics. Forty-nine patients with >1 year post-surgery were classified as either experiencing SWL (excess body weight loss, EWL, <50%, n = 22) or SigWR (total weight regain ≥15%, n = 38), with respective control groups. Energy intake (EI) was measured with a Food Frequency Questionnaire, eating behavior using the Dutch Eating Behavior Questionnaire and the Three-Factor Eating Questionnaire, and PA using both SenseWear Armbands and the International Physical Activity Questionnaire. Eating disorders, depression, and quality of life (QoL) were measured using the Eating Disorder Examination Questionnaire, Beck Depression Inventory II, and Impact of Weight on Quality of Life, respectively. EI, macronutrient distribution, and meal frequency were similar among groups. However, disinhibited eating behavior score was higher, while most subcategories from IWQOL were significantly lower in both SWL and SigWR groups compared with their respective controls. PA was significantly lower in the SWL and SigWR groups compared with the respective controls. There were no differences between groups regarding depression. Lower PA levels, disordered eating behavior and lower QoL are associated with unsuccessful weigh loss outcome after GB surgery. Longitudinal studies are needed to clarify the potential causal relationship between the previously described variables and SWL/SigWR after GB.

  6. XMM-Newton X-ray Observatory Guest Observer program (AO-1) at CASA

    NASA Technical Reports Server (NTRS)

    Skinner, Stephen L.

    2003-01-01

    In this research program, we obtained and analyzed X-ray observations of the Wolf-Rayet (WR) star WR 110 (HD 165688) using the XMM-Newton space-based observatory. Radio observations were also obtained using the Very Large Array (VLA) radio telescope located in New Mexico and operated by the Natl. Radio Astronomy Observatory (NRAO). This star was targeted for observations primarily because it is believed to be a single WR star without a companion. Single WR stars are thought to emit X-rays from cool plasma in shocks distributed throughout their powerful stellar winds. However, there has been little observational work done to test this idea since single WR stars are relatively weak X-ray sources and have been difficult to detect with previous generation telescopes. The launch of XMM-Newton provides a new telescope that is much more sensitive than its predecessors, allowing single WR stars to be studied in detail for the first time. X-ray emission was clearly detected from WR 110. Analysis of its spectrum yields a surprising result. Its X-ray emitting plasma is distributed over a range of temperatures and is dominated by relatively cool plasma with a characteristic temperature T is approximately 6 million K. Such plasma can be explained by existing theoretical wind shock models. However, the spectrum also shows hotter plasma whose temperature is uncertain but is thought to be in excess of T approximately 30 million K. The origin of this hotter plasma is yet unknown, but possible mechanisms are identified

  7. Investigations Concerning Hydrolysis and Stabilization of Antiradiation Compounds

    DTIC Science & Technology

    1982-01-01

    Stability of Unencapsulated WR 2721 31 V. DISCUSSION 35 A. Microencapsulation 35 1. Microspheres 35 2. Microcapsules 35 B. Hydrolytic Stability of...in 1.5 hours at 370C in buffered solutions of pH 1.0 or 3.0. 3^ The more promising microspheres and microcapsules released the WR 2721 within two...hours at pH 7.5 in buffered solutions. 4) Analytical procedures were developed for: "♦ WR 2721 (directly) in microcapsules using an HPLC

  8. The Definition of Epstein Barr Virus (EBV)’s Role in HTLV-III Infected USAF Personnel as Related to Disease Progression

    DTIC Science & Technology

    1988-12-27

    were considerably greater than those noted in patients with acute EBV induced infectious mononucleosis (IM), while the antibody levels to early... infectious (WR 1 - 6) (WR 1 only) (WR 1) Controls mononucleosis Oropharyngeat EBV 14/20 (70 ) 6/10 (60 ) 19/30 (63 ) 5/23 (21.7) 17/19 (89.5) Spontaneous... EBV infection in patients with ARC and AIDS. B cell lymphomas containing EBV - DNA are being reported in increased frequency in homosexuals and AIDS

  9. Influence of cycling history on the ventilatory response to cycle-ergometry in humans: a role for respiratory memory?

    PubMed

    Cathcart, Andrew J; Whipp, Brian J; Turner, Anthony P; Wilson, John; Ward, Susan A

    2010-01-01

    The ventilatory (V' E) mechanisms subserving stability of alveolar and arterial PCO2 (PACO2, PaCO2) during moderate exercise (< lactate threshold, thetaL) remain controversial. As long-term modulation has been argued to be an important contributor to this control process, we proposed that subjects with no experience of cycling (NEx) might provide insight into this issue. With no exercise familiarization, 9 sedentary NEx subjects and 9 age-, sex-, and activity-matched controls (C) who had cycled regularly for recreational purposes since childhood completed a square-wave (6-min stage) cycle-ergometry test: 10 W-WR1-WR2-WR1-10 W; WR1 range 25-45 W, WR2 range 50-90 W. WRs were subsequently confirmed to

  10. Preload of slowly digestible carbohydrate microspheres decreases gastric emptying rate of subsequent meal in humans.

    PubMed

    Cisse, Fatimata; Pletsch, Elizabeth A; Erickson, Daniel P; Chegeni, Mohammad; Hayes, Anna M R; Hamaker, Bruce R

    2017-09-01

    Gastric emptying rate influences how fast the nutrients of a meal are delivered to the body, and when slow, it moderates glycemic response and may impact satiety. Carbohydrates are one of the macronutrients that trigger the ileal brake, and we hypothesized that slowly digestible carbohydrate (SDC) administered in a premeal load would delay gastric emptying. A crossover design study was conducted with 10 healthy adults using fabricated SDC-microspheres (cooked) that were given 20 minutes before a non-nutritive viscous paste meal. There were 4 treatment arms, each separated by a 1-week washout period, consisting of (1) the paste alone, (2) a rapidly digesting maltodextrin (Polycose) preload followed by the paste 20 minutes later, (3) an SDC-microsphere preload followed by the paste, and (4) a comparably slower SDC-microsphere preload followed by the paste. A 13 C-labeled octanoic acid breath test method was used to measure gastric emptying, with the label incorporated into the non-nutritive paste. The microspheres were less than 1 mm in diameter (a size that does not require breakdown in the stomach before emptying) and, after cooking, were of the same density value. Compared with the paste alone, both of the SDC-microsphere preloads (slow and comparably slower digesting) decreased gastric emptying rate of the paste, with the latter having the most effect (half-emptying times of 1.7, 2.3, and 2.8 hours, respectively [each different at P<.05]). In conclusion, SDCs decreased gastric emptying rate, and this was suggested to be due to a triggering of the ileal brake. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. The effect of 2-[(aminopropyl)amino] ethanethiol on fission-neutron-induced DNA damage and repair.

    PubMed Central

    Grdina, D. J.; Sigdestad, C. P.; Dale, P. J.; Perrin, J. M.

    1989-01-01

    The effect(s) of the radioprotector 2-[(aminopropyl)amino] ethanethiol (WR 1065) on fission-neutron-induced DNA damage and repair in V79 Chinese hamster cells was determined by using a neutral filter elution procedure (pH 7.2). When required, WR1065, at a final working concentration of 4 mM, was added to the culture medium, either 30 min before and during irradiation with fission spectrum neutrons (beam energy of 0.85 MeV) from the JANUS research reactor, or for selected intervals of time following exposure. The frequency of neutron-induced DNA strand breaks as measured by neutral elution as a function of dose equalled that observed for 60Co gamma-ray-induced damage (relative biological effectiveness of one). In contrast to the protective effect exhibited by WR1065 in reducing 60Co-induced DNA damage, WR1065 was ineffective in reducing or protecting against induction of DNA strand breaks by JANUS neutrons. The kinetics of DNA double-strand rejoining were measured following neutron irradiation. In the absence of WR1065, considerable DNA degradation by cellular enzymes was observed. This process was inhibited when WR1065 was present. These results indicate that, under the conditions used, the quality (i.e. nature), rather than quantity, of DNA lesions (measured by neutral elution) formed by neutrons was significantly different from that formed by gamma-rays. PMID:2667608

  12. X-Ray Emission from Massive Stars in Cyg OB2

    NASA Astrophysics Data System (ADS)

    Rauw, G.; Nazé, Y.; Wright, N. J.; Drake, J. J.; Guarcello, M. G.; Prinja, R. K.; Peck, L. W.; Albacete Colombo, J. F.; Herrero, A.; Kobulnicky, H. A.; Sciortino, S.; Vink, J. S.

    2015-11-01

    We report on the analysis of the Chandra-ACIS data of O, B, and WR stars in the young association Cyg OB2. X-ray spectra of 49 O-stars, 54 B-stars, and 3 WR-stars are analyzed and for the brighter sources, the epoch dependence of the X-ray fluxes is investigated. The O-stars in Cyg OB2 follow a well-defined scaling relation between their X-ray and bolometric luminosities: {log}\\\\frac{{L}{{X}}}{{L}{bol}}=-7.2+/- 0.2. This relation is in excellent agreement with the one previously derived for the Carina OB1 association. Except for the brightest O-star binaries, there is no general X-ray overluminosity due to colliding winds in O-star binaries. Roughly half of the known B-stars in the surveyed field are detected, but they fail to display a clear relationship between LX and Lbol. Out of the three WR stars in Cyg OB2, probably only WR 144 is itself responsible for the observed level of X-ray emission, at a very low {log}\\\\frac{{L}{{X}}}{{L}{bol}}=-8.8+/- 0.2. The X-ray emission of the other two WR-stars (WR 145 and 146) is most probably due to their O-type companion along with a moderate contribution from a wind-wind interaction zone.

  13. Work reintegration after long-term sick leave: domains of influence on co-workers' ability to be supportive.

    PubMed

    Petersen, Kirsten Schultz; Labriola, Merete; Nielsen, Claus Vinther; Larsen, Eva Ladekjær

    2016-09-01

    The purpose of the study is to identify domains of influence on co-workers' ability to be supportive of returning worker during the work reintegration (WR) process. An ethnographic study design was chosen involving fieldwork at four different workplaces, at an emergency care service, a waste disposal company and at two nursing homes. Qualitative methods for inquiry were used including participant observation, individual- and group interviews of 30 participants. Data were coded and analysed according to a grounded theory approach. Four themes were identified related to domains of influence on co-workers' ability to be supportive of returning worker during the WR process: (1) organisation of work and level of interaction; (2) disruption of work routines, (3) relationship with returning worker and (4) attitudes towards sick leave. The WR process after long-term sick leave is not only influenced by the WR's arrangements made, but also by the co-workers' responses to the process. Work arrangements not only affect the returning worker's ability to return-to-work (RTW) successfully, but also the co-workers' ability to be supportive and their ability to take active part in the process. Implications for Rehabilitation The process of WR after long-term sick leave involves interaction with co-workers. Domains of influence is in the co-workers' perspective influencing their ability to be supportive during reintegration of a returning worker. Future WR management could benefit from integrating the conditions for co-worker support. We encourage co-workers to be involved in the RTW planning, monitoring and evaluation with particular focus on how the WR arrangements are influencing their work and their ability to be supportive.

  14. The Distribution of Massive Stars in M101

    NASA Astrophysics Data System (ADS)

    Bibby, J.; Shara, M.; Zurek, D.; Crowther, P. A.; Moffat, A. F. J.; Drissen, L.; Wilde, M.

    75 WR stars and 164 RSGs are identified in a single WFC3 pointing of our M101 survey. We find that within it's large star-forming complex NGC 5462 WR stars are preferentially located in the core whilst RSGs are found in the halo, suggesting two bursts of star-formation. A review of our WR candidates reveals that only ˜30% are detected in the archival broad-band ACS imaging whilst only ˜50% are associated with HII regions.

  15. Ring nebulae around Wolf-Rayet stars in M33

    NASA Technical Reports Server (NTRS)

    Drissen, Laurent; Shara, Michael M.; Moffat, Anthony F. J.

    1991-01-01

    Results of a systematic search for H II ring nebulae surrounding Wolf-Rayet (WR) stars in M33 are presented. Eleven objects are found to be good candidates, while eight others are classified as possible WR ring nebulae. The WR rings in M33 are larger on average than their Galactic counterparts, but the H-alpha luminosity of most of them is comparable to the bright Galactic wind-blown bubbles. The rings are associated with WC as well as with WN stars.

  16. AFRRI (Armed Forces Radiobiology Research Institute) Reports, October-December 1985.

    DTIC Science & Technology

    1985-01-01

    ability of WR-2721 to mitigate the early performance decrement ( PD ) produced by ionizing radiation. In the first study, rats trained on the accelerod motor...occur, (3) WR-2721 does not protect ś- for radiation-induced PD , and (4) WR-2721 combined with radiation disrupts performance more severely than either...interest is the decrement in performance ( PD ) that occurs 0033-7387/85 $3.00 2 Copyfht 0 1ř by Academic Pmrt Inc. AN fthts a" monaduction may form mvnud

  17. HST FGS1R Results On the Association Between Binary Wolf-Rayet Stars and Non-Thermal Radio Emission

    NASA Astrophysics Data System (ADS)

    Wallace, D. J.; Gies, D. R.; Nelan, E.; Leitherer, C.

    2000-12-01

    Two separate models have been proposed to explain the non-thermal emission detected in some Wolf-Rayet (WR) stars. In models based on single WR stars, this emission is proposed to arise via synchrotron radiative processes in the outer (intrinsically unstable) WR wind (e.g. White & Chen 1995). In models based on WR + O systems, this non-thermal radio emission is suggested to arise from the WR wind colliding with the wind of a companion (e.g. Williams et al. 1990). In order to be observed, the colliding winds region is believed to occur in wide binaries where the interaction zone is outside the WR radio photosphere (≈30 AU based on spherically symmetric uniform wind models). HST FGS1R observations of 9 non-thermal and 9, as a control group, purely thermal radio emitting stars attempted to verify the theory that this non-thermal emission is always a result of binary interactions. If the binary model is correct, then most or all of our non-thermal targets should have companions with projected separations of 0.01″ WR 48, no companions were found. While this result does not rule out the role of companions in producing the non-thermal radio emission, it does not support the companion hypothesis. These results do strongly suggest that a wind interaction region, if occurring, must lie closer to the WR star than previously believed. Support for this work was provided by NASA through grant number GO-8309 from the Space Telescope Science Institute, which is operated by AURA, Inc., under NASA contract NAS5-26555.

  18. Behavioral toxicity of selected radioprotectors

    NASA Astrophysics Data System (ADS)

    Landauer, M. R.; Davis, H. D.; Kumar, K. S.; Weiss, J. F.

    1992-10-01

    Effective radioprotection with minimal behavioral disruption is essential for the selection of protective agents to be used in manned spaceflight. This overview summarizes the studies on the behavioral toxicity of selected radioprotectors classified as phosphorothioates (WR-2721, WR-3689), bioactive lipids (16, 16 dimethylprostaglandin E2(DiPGE2), platelet activating factor (PAF), leukotriene C4), and immunomodulators (glucan, synthetic trehalose dicorynomycolate, and interleukin-1). Behavioral toxicity was examined in laboratory mice using a locomotor activity test. For all compounds tested, there was a dose-dependent decrease in locomotor behavior that paralleled the dose-dependent increase in radioprotection. While combinations of radioprotective compounds (DiPGE2 plus WR-2721) increased radioprotection, they also decreased locomotor activity. The central nervous system stimulant, caffeine, was able to mitigate the locomotor decrement produced by WR-3689 or PAF.

  19. The Results of the 2013 Pro-Am Wolf-Rayet Campaign

    NASA Astrophysics Data System (ADS)

    Aldoretta, E. J.; St-Louis, N.; Richardson, N. D.; Moffat, A. F. J.; Eversberg, T.; Hill, G. M.; World-Wide WR Pro-Am Campaign Team

    Professional and amateur astronomers around the world contributed to a 4-month long campaign in 2013, mainly in spectroscopy but also in photometry, interferometry and polarimetry, to observe the first 3 Wolf-Rayet stars discovered: WR 134 (WN6b), WR 135 (WC8) and WR 137 (WC7pd+O9). Each of these stars are interesting in their own way, showing a variety of stellar wind structures. The spectroscopic data from this campaign were reduced and analyzed for WR 134 in order to better understand its behavior and long-term periodicity in the context of CIRs in the wind. We will be presenting the results of these spectroscopic data, which include the confirmation of the CIR variability and a time-coherency of ˜ 40 days (half-life of ˜ 20 days).

  20. Thermal destruction of organic waste hydrophobicity for agricultural soils application.

    PubMed

    Comino, Francisco; Aranda, Víctor; Domínguez-Vidal, Ana; Ayora-Cañada, María José

    2017-11-01

    Use of organic amendments is a good strategy for combating the growing problem of soil degradation due to deterioration of organic matter content, particularly severe in semi-arid European Mediterranean regions, while at the same time providing an opportunity for recycling organic wastes. Olive mill pomace (OMP), the main by-product of the olive oil industry, is being used increasingly in olive grove soils for this purpose. Although the positive effects of OMP amendments have been widely studied, they also have some negative effects on soil. One of the most critical is that they increase water repellency (WR) due to the presence of poorly evolved, strongly aliphatic compounds. This detrimental effect has received very little attention, although it may impair plant water availability and infiltration rates, increase erosion and lower long-term soil quality. This study proposed, for the first time, thermal treatment as an effective way of reducing WR in organic amendments (i.e. mixtures of OMP, olive tree pruning, chicken manure and spent coffee grounds) prior to their application to soil. Thermal treatment at 275 °C proved effective in removing WR, while lower temperatures (175 or 225 °C) can even increase it. Changes by thermal treatment in the characteristics of the organic amendments studied with FTIR and UV-Vis spectroscopy and thermogravimetric analysis showed that it strongly reduced the aliphatic compounds mainly responsible for their hydrophobicity, concentrated aromatic compounds and increased thermostability. Heating also reduced phytotoxicity, making all of the organic amendments usable in the field (germination index over 100%). Therefore, heating at 275 °C could be an acceptable option for removing WR from organic amendments, enhancing their quality with more stable evolved characteristics. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Winds from stripped low-mass helium stars and Wolf-Rayet stars

    NASA Astrophysics Data System (ADS)

    Vink, Jorick S.

    2017-11-01

    We present mass-loss predictions from Monte Carlo radiative transfer models for helium (He) stars as a function of stellar mass, down to 2 M⊙. Our study includes both massive Wolf-Rayet (WR) stars and low-mass He stars that have lost their envelope through interaction with a companion. For these low-mass He stars we predict mass-loss rates that are an order of magnitude smaller than by extrapolation of empirical WR mass-loss rates. Our lower mass-loss rates make it harder for these elusive stripped stars to be discovered via line emission, and we should attempt to find these stars through alternative methods instead. Moreover, lower mass-loss rates make it less likely that low-mass He stars provide stripped-envelope supernovae (SNe) of type Ibc. We express our mass-loss predictions as a function of L and Z and not as a function of the He abundance, as we do not consider this physically astute given our earlier work. The exponent of the M⊙ versus Z dependence is found to be 0.61, which is less steep than relationships derived from recent empirical atmospheric modelling. Our shallower exponent will make it more challenging to produce "heavy" black holes of order 40 M⊙, as recently discovered in the gravitational wave event GW 150914, making low metallicity for these types of events even more necessary.

  2. Potential gene flow from transgenic rice (Oryza sativa L.) to different weedy rice (Oryza sativa f. spontanea) accessions based on reproductive compatibility.

    PubMed

    Song, Xiaoling; Liu, Linli; Wang, Zhou; Qiang, Sheng

    2009-08-01

    The possibility of gene flow from transgenic crops to wild relatives may be affected by reproductive capacity between them. The potential gene flow from two transgenic rice lines containing the bar gene to five accessions of weedy rice (WR1-WR5) was determined through examination of reproductive compatibility under controlled pollination. The pollen grain germination of two transgenic rice lines on the stigma of all weedy rice, rice pollen tube growth down the style and entry into the weedy rice ovary were similar to self-pollination in weedy rice. However, delayed double fertilisation and embryo abortion in crosses between WR2 and Y0003 were observed. Seed sets between transgenic rice lines and weedy rice varied from 8 to 76%. Although repeated pollination increased seed set significantly, the rank of the seed set between the weedy rice accessions and rice lines was not changed. The germination rates of F(1) hybrids were similar or greater compared with respective females. All F(1) plants expressed glufosinate resistance in the presence of glufosinate selection pressure. The frequency of gene flow between different weedy rice accessions and transgenic herbicide-resistant rice may differ owing to different reproductive compatibility. This result suggests that, when wild relatives are selected as experimental materials for assessing the gene flow of transgenic rice, it is necessary to address the compatibility between transgenic rice and wild relatives.

  3. Acute kinematic and kinetic adaptations to wearable resistance during vertical jumping.

    PubMed

    Macadam, Paul; Simperingham, Kim D; Cronin, John B; Couture, Grace; Evison, Chloe

    2017-06-01

    One variation of vertical jump (VJ) training is resisted or weighted jump training, where wearable resistance (WR) enables jumping to be overloaded in a movement specific manner. A two-way analysis of variance with Bonferroni post hoc contrasts was used to determine the acute changes in VJ performance with differing load magnitudes and load placements. Kinematic and kinetic data were quantified using a force plate and contact mat. Twenty sport active subjects (age: 27.8 ± 3.8 years; body mass (BM): 70.2 ± 12.2 kg; height: 1.74 ± 0.78 m) volunteered to participate in the study. Subjects performed the counter movement jump (CMJ), drop jump (DJ) and pogo jump (PJ) wearing no resistance, 3% or 6% BM affixed to the upper or lower body. The main finding in terms of the landing phase was that the effect of WR was non-significant (P > .05) on peak ground reaction force. With regard to the propulsive phase the main findings were that for both the CMJ and DJ, WR resulted in a significant (P < .05) decrease in jump height (CMJ: -12% to -17%, DJ: -10% to -14%); relative peak power (CMJ: -8% to -17%, DJ: -7% to -10%); and peak velocity (CMJ: -4% to -7%, DJ: -3% to -8%); while PJ reactive strength index was significantly reduced (-15% to -21%) with all WR conditions. Consideration should be given to the inclusion of WR in sports where VJ's are important components as it may provide a novel movement specific training stimulus. Highlights WR of 3 or 6 % BM provided a means to overload the subjects in this study resulting in decreased propulsive power and velocity that lead to a reduced jump height and landing force. Specific strength exercises that closely mimic sporting performance are more likely to optimise transference, therefore WR with light loads of 3-6% body mass (BM)appear a suitable tool for movement specific overload training and maximising transference to sporting performance. Practitioners can safely load their athletes with upper or lower

  4. Vectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition.

    PubMed

    Kleinpeter, Patricia; Fend, Laetitia; Thioudellet, Christine; Geist, Michel; Sfrontato, Nathalie; Koerper, Véronique; Fahrner, Catherine; Schmitt, Doris; Gantzer, Murielle; Remy-Ziller, Christelle; Brandely, Renée; Villeval, Dominique; Rittner, Karola; Silvestre, Nathalie; Erbs, Philippe; Zitvogel, Laurence; Quéméneur, Eric; Préville, Xavier; Marchand, Jean-Baptiste

    2016-01-01

    We report here the successful vectorization of a hamster monoclonal IgG (namely J43) recognizing the murine Programmed cell death-1 (mPD-1) in Western Reserve (WR) oncolytic vaccinia virus. Three forms of mPD-1 binders have been inserted into the virus: whole antibody (mAb), Fragment antigen-binding (Fab) or single-chain variable fragment (scFv). MAb, Fab and scFv were produced and assembled with the expected patterns in supernatants of cells infected by the recombinant viruses. The three purified mPD-1 binders were able to block the binding of mPD-1 ligand to mPD-1 in vitro . Moreover, mAb was detected in tumor and in serum of C57BL/6 mice when the recombinant WR-mAb was injected intratumorally (IT) in B16F10 and MCA 205 tumors. The concentration of circulating mAb detected after IT injection was up to 1,900-fold higher than the level obtained after a subcutaneous (SC) injection (i.e., without tumor) confirming the virus tropism for tumoral cells and/or microenvironment. Moreover, the overall tumoral accumulation of the mAb was higher and lasted longer after IT injection of WR-mAb1, than after IT administration of 10 µg of J43. The IT injection of viruses induced a massive infiltration of immune cells including activated lymphocytes (CD8 + and CD4 + ). Interestingly, in the MCA 205 tumor model, WR-mAb1 and WR-scFv induced a therapeutic control of tumor growth similar to unarmed WR combined to systemically administered J43 and superior to that obtained with an unarmed WR. These results pave the way for next generation of oncolytic vaccinia armed with immunomodulatory therapeutic proteins such as mAbs.

  5. Vectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition

    PubMed Central

    Kleinpeter, Patricia; Fend, Laetitia; Thioudellet, Christine; Geist, Michel; Sfrontato, Nathalie; Koerper, Véronique; Fahrner, Catherine; Schmitt, Doris; Gantzer, Murielle; Remy-Ziller, Christelle; Brandely, Renée; Villeval, Dominique; Rittner, Karola; Silvestre, Nathalie; Erbs, Philippe; Zitvogel, Laurence; Quéméneur, Eric; Préville, Xavier; Marchand, Jean-Baptiste

    2016-01-01

    ABSTRACT We report here the successful vectorization of a hamster monoclonal IgG (namely J43) recognizing the murine Programmed cell death-1 (mPD-1) in Western Reserve (WR) oncolytic vaccinia virus. Three forms of mPD-1 binders have been inserted into the virus: whole antibody (mAb), Fragment antigen-binding (Fab) or single-chain variable fragment (scFv). MAb, Fab and scFv were produced and assembled with the expected patterns in supernatants of cells infected by the recombinant viruses. The three purified mPD-1 binders were able to block the binding of mPD-1 ligand to mPD-1 in vitro. Moreover, mAb was detected in tumor and in serum of C57BL/6 mice when the recombinant WR-mAb was injected intratumorally (IT) in B16F10 and MCA 205 tumors. The concentration of circulating mAb detected after IT injection was up to 1,900-fold higher than the level obtained after a subcutaneous (SC) injection (i.e., without tumor) confirming the virus tropism for tumoral cells and/or microenvironment. Moreover, the overall tumoral accumulation of the mAb was higher and lasted longer after IT injection of WR-mAb1, than after IT administration of 10 µg of J43. The IT injection of viruses induced a massive infiltration of immune cells including activated lymphocytes (CD8+ and CD4+). Interestingly, in the MCA 205 tumor model, WR-mAb1 and WR-scFv induced a therapeutic control of tumor growth similar to unarmed WR combined to systemically administered J43 and superior to that obtained with an unarmed WR. These results pave the way for next generation of oncolytic vaccinia armed with immunomodulatory therapeutic proteins such as mAbs. PMID:27853644

  6. The Vast Population of Wolf-Rayet and Red Supergiant Stars in M101. I. Motivation and First Results

    NASA Astrophysics Data System (ADS)

    Shara, Michael M.; Bibby, Joanne L.; Zurek, David; Crowther, Paul A.; Moffat, Anthony F. J.; Drissen, Laurent

    2013-12-01

    Assembling a catalog of at least 10,000 Wolf-Rayet (W-R) stars is an essential step in proving (or disproving) that these stars are the progenitors of Type Ib and Type Ic supernovae. To this end, we have used the Hubble Space Telescope (HST) to carry out a deep, He II optical narrowband imaging survey of the ScI spiral galaxy M101. Almost the entire galaxy was imaged with the unprecedented depth and resolution that only the HST affords. Differenced with archival broadband images, the narrowband images allow us to detect much of the W-R star population of M101. We describe the extent of the survey and our images, as well as our data reduction procedures. A detailed broadband-narrowband imaging study of a field east of the center of M101, containing the giant star-forming region NGC 5462, demonstrates our completeness limits, how we find W-R candidates, their properties and spatial distribution, and how we rule out most contaminants. We use the broadband images to locate luminous red supergiant (RSG) candidates. The spatial distributions of the W-R and RSG stars near NGC 5462 are strikingly different. W-R stars dominate the complex core, while RSGs dominate the complex halo. Future papers in this series will describe and catalog more than a thousand W-R and RSG candidates that are detectable in our images, as well as spectra of many of those candidates.

  7. Thermochronometrically constrained anatomy and evolution of a Miocene extensional accommodation zone and tilt domain boundary: The southern Wassuk Range, Nevada

    NASA Astrophysics Data System (ADS)

    Gorynski, Kyle E.; Stockli, Daniel F.; Douglas Walker, J.

    2013-06-01

    (AHe) and Zircon (ZHe) (U-Th)/He thermochronometric data from the southern Wassuk Range (WR) coupled with 40Ar/39Ar age data from the overlying tilted Tertiary section are used to constrain the thermal evolution of an extensional accommodation zone and tilt-domain boundary. AHe and ZHe data record two episodes of rapid cooling related to the tectonic exhumation of the WR fault block beginning at ~15 and ~4 Ma. Extension was accommodated through fault-block rotation and variably tilted the southern WR to the west from ~60°-70° in the central WR to ~15°-35° in the southernmost WR and Pine Grove Hills, and minimal tilting in the Anchorite Hills and along the Mina Deflection to the south. Middle Miocene geothermal gradient estimates record heating immediately prior to large-magnitude extension that was likely coeval with the extrusion of the Lincoln Flat andesite at ~14.8 Ma. Geothermal gradients increase from ~19° ± 4°C/km to ≥ 65° ± 20°C/km toward the Mina Deflection, suggesting that it was the focus of Middle Miocene arc magmatism in the upper crust. The decreasing thickness of tilt blocks toward the south resulted from a shallowing brittle/ductile transition zone. Postmagmatic Middle Miocene extension and fault-block advection were focused in the northern and central WR and coincidentally moderated the large lateral thermal gradient within the uppermost crust.

  8. The vast population of Wolf-Rayet and red supergiant stars in M101. I. Motivation and first results

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shara, Michael M.; Bibby, Joanne L.; Zurek, David

    Assembling a catalog of at least 10,000 Wolf-Rayet (W-R) stars is an essential step in proving (or disproving) that these stars are the progenitors of Type Ib and Type Ic supernovae. To this end, we have used the Hubble Space Telescope (HST) to carry out a deep, He II optical narrowband imaging survey of the ScI spiral galaxy M101. Almost the entire galaxy was imaged with the unprecedented depth and resolution that only the HST affords. Differenced with archival broadband images, the narrowband images allow us to detect much of the W-R star population of M101. We describe the extentmore » of the survey and our images, as well as our data reduction procedures. A detailed broadband-narrowband imaging study of a field east of the center of M101, containing the giant star-forming region NGC 5462, demonstrates our completeness limits, how we find W-R candidates, their properties and spatial distribution, and how we rule out most contaminants. We use the broadband images to locate luminous red supergiant (RSG) candidates. The spatial distributions of the W-R and RSG stars near NGC 5462 are strikingly different. W-R stars dominate the complex core, while RSGs dominate the complex halo. Future papers in this series will describe and catalog more than a thousand W-R and RSG candidates that are detectable in our images, as well as spectra of many of those candidates.« less

  9. 76 FR 68459 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-04

    ... designate a class of employees from W.R. Grace and Company in Curtis Bay, Maryland, as an addition to the... by W.R. Grace and Company in Curtis Bay, Maryland, for the operational period from May 1, 1956...

  10. The Wolf-Rayet star population in the most massive giant H II regions of M33

    NASA Technical Reports Server (NTRS)

    Drissen, Laurent; Moffat, Anthony F. J.; Shara, Michael M.

    1990-01-01

    Narrow-band images of NGC 604, NGC 595, and NGC 592, the most massive giant H II regions (GHRs) in M33 have been obtained, in order to study their Wolf-Rayet content. These images reveal the presence of nine candidates in NGC 604 (seven WN, two WC), 10 in NGC 595 (nine WN, one WC), and two in NGC 592 (two WN). Precise positions and estimated magnitudes are given for the candidates, half of which have so far been confirmed spectroscopically as genuine W-R stars. The flux in the emission lines of all candidates is comparable to that of normal Galactic W-R stars of similar subtype. A few of the putative superluminous W-R stars are shown to be close visual double or multiple stars; their newly estimated luminosities are now more compatible with those of normal W-R stars. NGC 595 seems to be overabundant in W-R stars for its mass compared to other GHRs, while NGC 604 is normal. Factors influencing the W-R/O number ratio in GHRs are discussed: metallicity and age appear to be the most important.

  11. US/UK Loan Account Project Status PMOD477

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stevens, Patrice A.

    2012-07-12

    The viewgraphs describe the status of PMOD477 for LANL. The meeting will occur at DOE-HQ with NA-11 and Military Applications personnel in attendance. Serves to repatriate material with a balance to zero by December 2012. Phase 1 -- Establish formality of operations for War Reserve (WR): Complete surrogate taskings to A90 through a Materials Channel and perform US/UK lessons learned; Complete the US/UK agreed Quality Acceptance Plan, Materials Plan, Shipping procedure, and establish the formal UK/US point of contacts. Phase 2 -- Metal Manufacture (WR): Process material and store material as electrorefined metal (ER) rings, with initial assay and isotopicmore » analysis, prior to manufacturing. Material is cast into accepted configuration and appropriate acceptance document for each aliquot will be generated. Phase 3 -- Intermediate Material Manufacture, Packaging and Shipping (WR): Continue processing of the material in accepted configuration with appropriate acceptance documentation for each aliquot. Provide an initial tasking of the material owed to UK including appropriate quality acceptance documentation. Phase 4 -- Complete Tasking (WR). Phase 5 -- Residue Processing (Non-WR): Complete processing of residue material and waste into accepted configuration with appropriate acceptance document for disposal.« less

  12. Baseline Tumor Lipiodol Uptake after Transarterial Chemoembolization for Hepatocellular Carcinoma: Identification of a Threshold Value Predicting Tumor Recurrence.

    PubMed

    Matsui, Yusuke; Horikawa, Masahiro; Jahangiri Noudeh, Younes; Kaufman, John A; Kolbeck, Kenneth J; Farsad, Khashayar

    2017-12-01

    The aim of the study was to evaluate the association between baseline Lipiodol uptake in hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE) with early tumor recurrence, and to identify a threshold baseline uptake value predicting tumor response. A single-institution retrospective database of HCC treated with Lipiodol-TACE was reviewed. Forty-six tumors in 30 patients treated with a Lipiodol-chemotherapy emulsion and no additional particle embolization were included. Baseline Lipiodol uptake was measured as the mean Hounsfield units (HU) on a CT within one week after TACE. Washout rate was calculated dividing the difference in HU between the baseline CT and follow-up CT by time (HU/month). Cox proportional hazard models were used to correlate baseline Lipiodol uptake and other variables with tumor response. A receiver operating characteristic (ROC) curve was used to identify the optimal threshold for baseline Lipiodol uptake predicting tumor response. During the follow-up period (mean 5.6 months), 19 (41.3%) tumors recurred (mean time to recurrence = 3.6 months). In a multivariate model, low baseline Lipiodol uptake and higher washout rate were significant predictors of early tumor recurrence ( P = 0.001 and < 0.0001, respectively). On ROC analysis, a threshold Lipiodol uptake of 270.2 HU was significantly associated with tumor response (95% sensitivity, 93% specificity). Baseline Lipiodol uptake and washout rate on follow-up were independent predictors of early tumor recurrence. A threshold value of baseline Lipiodol uptake > 270.2 HU was highly sensitive and specific for tumor response. These findings may prove useful for determining subsequent treatment strategies after Lipiodol TACE.

  13. Preclinical and clinical aspects on the use of amifostine as chemoprotector in neuroblastoma patients.

    PubMed

    Fulda, S; Fichtner, I; Hero, B; Berthold, F

    2001-01-01

    In several studies in adults, amifostine (WR-2721) and its active metabolite WR-1065 have shown protection against myelo- and nephrotoxicity of chemotherapeutic agents without compromising cytotoxic efficacy to the tumor. In the present study, the effect of amifostine and WR-1065 on neuroblastoma tumor growth and its protective potential for hematotoxicity were investigated. Neither amifostine nor WR-1065 reduced the cytotoxic effect of six drugs commonly used for this tumor when tested on neuroblastoma cells in vitro. In mice carrying human xeno-transplanted neuroblastoma, tumor growth and antitumor activity of chemotherapy were unaffected by amifostine. In addition, hematotoxicity of alkylators was relieved in some cases. In patients with neuroblastoma, amifostine only slightly reduced bone marrow toxicity and was highly emetogenic. Therefore, amifostine warrants further investigation before its widespread clinical use in the treatment of children with neuroblastoma.

  14. [Biomechanical characteristics of the wiping reflex cycle].

    PubMed

    Berkinblit, M B; Zharkova, I S; Fel'dman, A G; Fukson, O I

    1984-01-01

    Multijoint goal-directed hindlimb movements in response to chemical stimulation delivered to different skin sites on the medial back surface (wiping reflex-WR) were filmed and analysed in spinal or intact frogs Rana temporaria. Each WR cycle was divisible into five phases (flexion, lifting, aiming, wiping and extension) usually separated from each other by postural interruptions. One or several of the phases might spontaneously be reduced or deleted at all (e. g. the extension phase), although the WR was still effective. Such a reduction was, as a rule, observed in intact frogs while spinal ones usually exhibited the maximum phase sequence. It is suggested that the central spinal generator of the WR is formed of separate functional blocks each of which specifies a certain interjoint coordination and brings the joints to the central-conditioned equilibrium positions.

  15. VLTI and KI Interferometric Observations of Massive Evolved Stars and Their Dusty Circumstellar Environments

    NASA Astrophysics Data System (ADS)

    Wallace, Debra J.; Danchi, W. C.; Rajagopal, J.; Chesneau, O.; Lopez, B.; Menut, J.; Monnier, J.; Tuthill, P.; Ireland, M.; Barry, R.; Richardson, L. J.

    2007-12-01

    Recent aperture-masking and interferometric observations of late-type WC Wolf-Rayet stars strongly support the theory that dust formation in these objects is a result of colliding winds in binary systems. To explore and quantify this possible explanation, we have conducted a high-resolution interferometric survey of late-type massive stars utilizing the VLTI, KI, IOTA, and FGS1r interferometers. We present here the motivation for this study. We also present the first results from the MIDI instrument on the VLTI, and the KI and IOTA observations. Our VLTI study is aimed primarily at resolving and characterizing the dust around the WC9 star WR 85a and the LBV WR 122, both dust-producing but at different phases of massive star evolution. Our IOTA and KI interferometric observations resolve the WR star WR 137 into a dust-producing binary system.

  16. Spatial distribution of soil moisture and hydrophobicity in the immediate period after a grassland fire in Lithuania

    NASA Astrophysics Data System (ADS)

    Pereira, P.; Pundyte, N.; Vaitkute, D.; Cepanko, V.; Pranskevicius, M.; Ubeda, X.; Mataix-Solera, J.; Cerda, A.

    2012-04-01

    Fire can affect significantly soil moisture (SM) and water repellency (WR) in the immediate period after the fire due the effect of the temperatures into soil profile and ash. This impact can be very heterogeneous, even in small distances, due to different conditions of combustion (e.g. fuel and soil moisture, fuel amount and type, distribution and connection, and geomorphological variables as aspect and slope) that influences fire temperature and severity. The aim of this work it is study the spatial distribution of SM and WR in a small plot (400 m2 with a sampling distance of 5 m) immediately after the a low severity grassland fire.. This was made in a burned but also in a control (unburned) plot as reference to can compare. In each plot we analyzed a total of 25 samples. SM was measured gravimetrically and WR with the water drop penetration time test (WDPT). Several interpolation methods were tested in order to identify the best predictor of SM and WR, as the Inverse Distance to a Weight (IDW) (with the power of 1,2,3,4 and 5), Local Polynomial with the first and second polynomial order, Polynomial Regression (PR), Radial Basis Functions (RBF) as Multilog (MTG), Natural Cubic Spline (NCS), Multiquadratic (MTQ), Inverse Multiquadratic (IMTQ) and Thin Plate Spline (TPS) and Ordinary Kriging. Interpolation accuracy was observed with the cross-validation method that is achieved by taking each observation in turn out of the sample and estimating from the remaining ones. The errors produced in each interpolation allowed us to calculate the Root Mean Square Error (RMSE). The best method is the one that showed the lower RMSE. The results showed that on average the SM in the control plot was 13.59 % (±2.83) and WR 2.9 (±1.3) seconds (s). The majority of the soils (88%) were hydrophilic (WDPT <5s). SM in the control plot showed a weak negative relationship with WR (r=-0.33, p<0.10). The coefficient of variation (CV%) of SM was 20.77% and SW of 44.62%. In the burned plot

  17. Number of Players and Relative Pitch Area per Player: Comparing Their Influence on Heart Rate and Physical Demands in Under-12 and Under-13 Football Players

    PubMed Central

    Castellano, Julen; Puente, Asier; Echeazarra, Ibon; Usabiaga, Oidui; Casamichana, David

    2016-01-01

    The aim of the present study is to analyse the influence of different large-sided games (LSGs) on the physical and physiological variables in under-12s (U12) and -13s (U13) soccer players. The effects of the combination of different number of players per team, 7, 9, and 11 (P7, P9, and P11, respectively) with three relative pitch areas, 100, 200, and 300 m2 (A100, A200, and A300, respectively), were analysed in this study. The variables analysed were: 1) global indicator such as total distance (TD); work:rest ratio (W:R); player-load (PL) and maximal speed (Vmax); 2) heart rate (HR) mean and time spent in different intensity zones of HR (<75%, 75–84%, 84–90% and >90%), and; 3) five absolute (<8, 8–13, 13–16 and >16 Km h-1) and three relative speed categories (<40%, 40–60% and >60% Vmax). The results support the theory that a change in format (player number and pitch dimensions) affects no similarly in the two players categories. Although it can seem that U13 players are more demanded in this kind of LSG, when the work load is assessed from a relative point of view, great pitch dimensions and/or high number of player per team are involved in the training task to the U12 players. The results of this study could alert to the coaches to avoid some types of LSGs for the U12 players such as: P11 played in A100, A200 or A300, P9 played in A200 or A300 and P7 played in A300 due to that U13>U12 in several physical and physiological variables (W:R, time spent in 84–90%HRmax, distance in 8–13 and 13–16 Km h-1 and time spent in 40–60%Vmax). These results may help youth soccer coaches to plan the progressive introduction of LSGs so that task demands are adapted to the physiological and physical development of participants. PMID:26752422

  18. Acute Consumption of Resistant Starch Reduces Food Intake but Has No Effect on Appetite Ratings in Healthy Subjects.

    PubMed

    Ble-Castillo, Jorge L; Juárez-Rojop, Isela E; Tovilla-Zárate, Carlos A; García-Vázquez, Carlos; Servin-Cruz, Magda Z; Rodríguez-Hernández, Arturo; Araiza-Saldaña, Claudia I; Nolasco-Coleman, Ana M; Díaz-Zagoya, Juan C

    2017-07-04

    Previous studies have shown the benefits of native banana starch (NBS) supplementation in improving glucose metabolism and reducing body weight (BW) in humans. However, the effect of this starch on appetite regulation is unknown. The aim of this study was to examine the effects of NBS rich resistant starch on subjective measurements of appetite, energy intake, and appetite hormones in healthy subjects. Postprandial glucose and insulin responses were also assessed. In a randomized, single-blind, crossover study, 28 healthy young subjects consumed a beverage containing either 40 g of NBS or 40 g of digestible corn starch (DCS) on two separate occasions. Effects on appetite were estimated using visual analogue scales (VAS) and satiety hormone responses. At the end of the intervention, participants were provided with a pre-weighed ad libitum homogeneous test meal. After a washout period of 1 week, subjects received the alternative treatment. NBS supplementation induced a reduction in food intake, glucose area under the curve (AUC)-180 min, and insulin AUC-180 min. However, there was no associated effect on the subjective appetite ratings or gut hormones. NBS supplementation may help to reduce meal size and control BW.

  19. Acute Consumption of Resistant Starch Reduces Food Intake but Has No Effect on Appetite Ratings in Healthy Subjects

    PubMed Central

    Ble-Castillo, Jorge L.; Juárez-Rojop, Isela E.; Tovilla-Zárate, Carlos A.; García-Vázquez, Carlos; Servin-Cruz, Magda Z.; Rodríguez-Hernández, Arturo; Araiza-Saldaña, Claudia I.; Nolasco-Coleman, Ana M.

    2017-01-01

    Previous studies have shown the benefits of native banana starch (NBS) supplementation in improving glucose metabolism and reducing body weight (BW) in humans. However, the effect of this starch on appetite regulation is unknown. The aim of this study was to examine the effects of NBS rich resistant starch on subjective measurements of appetite, energy intake, and appetite hormones in healthy subjects. Postprandial glucose and insulin responses were also assessed. In a randomized, single-blind, crossover study, 28 healthy young subjects consumed a beverage containing either 40 g of NBS or 40 g of digestible corn starch (DCS) on two separate occasions. Effects on appetite were estimated using visual analogue scales (VAS) and satiety hormone responses. At the end of the intervention, participants were provided with a pre-weighed ad libitum homogeneous test meal. After a washout period of 1 week, subjects received the alternative treatment. NBS supplementation induced a reduction in food intake, glucose area under the curve (AUC)-180 min, and insulin AUC-180 min. However, there was no associated effect on the subjective appetite ratings or gut hormones. NBS supplementation may help to reduce meal size and control BW. PMID:28677623

  20. Salvage of infected craniotomy bone flaps with the wash-in, wash-out indwelling antibiotic irrigation system. Technical note and case series of 12 patients.

    PubMed

    Auguste, Kurtis I; McDermott, Michael W

    2006-10-01

    When complicated by infection, craniotomy bone flaps are commonly removed, discarded, and delayed cranioplasty is performed. This treatment paradigm is costly, carries the risks associated with additional surgery, and may cause cosmetic deformities. The authors present their experience with an indwelling antibiotic irrigation system used for the sterilization and salvage of infected bone flaps as an alternative to their removal and replacement. The authors retrospectively reviewed the medical records for 12 patients with bone flap infections following craniotomy who received treatment with the wash-in, wash-out indwelling antibiotic irrigation system. Infected flaps were removed and scrubbed with povidone-iodine solution and soaked in 1.5% hydrogen peroxide while the wound was debrided. The bone flaps were returned to the skull and the irrigation system was installed. Antibiotic medication was infused through the system for a mean of 5 days. Intravenous antibiotic therapy was continued for 2 weeks and oral antibiotics for 3 months postoperatively. Wound checks were performed at clinic follow-up visits, and there was a mean follow-up period of 13 months. Eleven of the 12 patients who had undergone placement of the bone flap irrigation system experienced complete resolution of the infection. In five patients there was involvement of the nasal sinus cavities, and in four there was a history of radiation treatment. In the one patient whose infection recurred, there was both involvement of the nasal sinuses and a history of extensive radiation treatment. Infected bone flaps can be salvaged, thus avoiding the cost, risk, and possible disfigurement associated with flap removal and delayed cranioplasty. Although prior radiation treatment and involvement of the nasal sinuses may interfere with wound healing and clearance of the infection, these factors should not preclude the use of irrigation with antibiotic agents for bone flap salvage.