Responding to Disaster with a Service Learning Project for Honors Students

ERIC Educational Resources Information Center

Yoder, Stephen A.

2013-01-01

On Thursday, April 27, 2011, one of the worst natural disasters in the history of Alabama struck in the form of ferocious tornadoes touching down in various parts of the state. The dollar amount of the property damage was in the billions. Lives were lost and thousands of survivors' lives were seriously and in many cases forever disrupted. A few…

Assessing the robustness of passive scattering proton therapy with regard to local recurrence in stage III non-small cell lung cancer: a secondary analysis of a phase II trial.

PubMed

Zhu, Zhengfei; Liu, Wei; Gillin, Michael; Gomez, Daniel R; Komaki, Ritsuko; Cox, James D; Mohan, Radhe; Chang, Joe Y

2014-05-06

We assessed the robustness of passive scattering proton therapy (PSPT) plans for patients in a phase II trial of PSPT for stage III non-small cell lung cancer (NSCLC) by using the worst-case scenario method, and compared the worst-case dose distributions with the appearance of locally recurrent lesions. Worst-case dose distributions were generated for each of 9 patients who experienced recurrence after concurrent chemotherapy and PSPT to 74 Gy(RBE) for stage III NSCLC by simulating and incorporating uncertainties associated with set-up, respiration-induced organ motion, and proton range in the planning process. The worst-case CT scans were then fused with the positron emission tomography (PET) scans to locate the recurrence. Although the volumes enclosed by the prescription isodose lines in the worst-case dose distributions were consistently smaller than enclosed volumes in the nominal plans, the target dose coverage was not significantly affected: only one patient had a recurrence outside the prescription isodose lines in the worst-case plan. PSPT is a relatively robust technique. Local recurrence was not associated with target underdosage resulting from estimated uncertainties in 8 of 9 cases.

Estimated cost of universal public coverage of prescription drugs in Canada

PubMed Central

Morgan, Steven G.; Law, Michael; Daw, Jamie R.; Abraham, Liza; Martin, Danielle

2015-01-01

Background: With the exception of Canada, all countries with universal health insurance systems provide universal coverage of prescription drugs. Progress toward universal public drug coverage in Canada has been slow, in part because of concerns about the potential costs. We sought to estimate the cost of implementing universal public coverage of prescription drugs in Canada. Methods: We used published data on prescribing patterns and costs by drug type, as well as source of funding (i.e., private drug plans, public drug plans and out-of-pocket expenses), in each province to estimate the cost of universal public coverage of prescription drugs from the perspectives of government, private payers and society as a whole. We estimated the cost of universal public drug coverage based on its anticipated effects on the volume of prescriptions filled, products selected and prices paid. We selected these parameters based on current policies and practices seen either in a Canadian province or in an international comparator. Results: Universal public drug coverage would reduce total spending on prescription drugs in Canada by $7.3 billion (worst-case scenario $4.2 billion, best-case scenario $9.4 billion). The private sector would save $8.2 billion (worst-case scenario $6.6 billion, best-case scenario $9.6 billion), whereas costs to government would increase by about $1.0 billion (worst-case scenario $5.4 billion net increase, best-case scenario $2.9 billion net savings). Most of the projected increase in government costs would arise from a small number of drug classes. Interpretation: The long-term barrier to the implementation of universal pharmacare owing to its perceived costs appears to be unjustified. Universal public drug coverage would likely yield substantial savings to the private sector with comparatively little increase in costs to government. PMID:25780047

Estimated cost of universal public coverage of prescription drugs in Canada.

PubMed

Morgan, Steven G; Law, Michael; Daw, Jamie R; Abraham, Liza; Martin, Danielle

2015-04-21

With the exception of Canada, all countries with universal health insurance systems provide universal coverage of prescription drugs. Progress toward universal public drug coverage in Canada has been slow, in part because of concerns about the potential costs. We sought to estimate the cost of implementing universal public coverage of prescription drugs in Canada. We used published data on prescribing patterns and costs by drug type, as well as source of funding (i.e., private drug plans, public drug plans and out-of-pocket expenses), in each province to estimate the cost of universal public coverage of prescription drugs from the perspectives of government, private payers and society as a whole. We estimated the cost of universal public drug coverage based on its anticipated effects on the volume of prescriptions filled, products selected and prices paid. We selected these parameters based on current policies and practices seen either in a Canadian province or in an international comparator. Universal public drug coverage would reduce total spending on prescription drugs in Canada by $7.3 billion (worst-case scenario $4.2 billion, best-case scenario $9.4 billion). The private sector would save $8.2 billion (worst-case scenario $6.6 billion, best-case scenario $9.6 billion), whereas costs to government would increase by about $1.0 billion (worst-case scenario $5.4 billion net increase, best-case scenario $2.9 billion net savings). Most of the projected increase in government costs would arise from a small number of drug classes. The long-term barrier to the implementation of universal pharmacare owing to its perceived costs appears to be unjustified. Universal public drug coverage would likely yield substantial savings to the private sector with comparatively little increase in costs to government. © 2015 Canadian Medical Association or its licensors.

Electrical Evaluation of RCA MWS5001D Random Access Memory, Volume 5, Appendix D

NASA Technical Reports Server (NTRS)

Klute, A.

1979-01-01

The electrical characterization and qualification test results are presented for the RCA MWS 5001D random access memory. The tests included functional tests, AC and DC parametric tests, AC parametric worst-case pattern selection test, determination of worst-case transition for setup and hold times, and a series of schmoo plots. Average input high current, worst case input high current, output low current, and data setup time are some of the results presented.

Estimation of human damage and economic loss of buildings for the worst-credible scenario of tsunami inundation in the city of Augusta, Italy

NASA Astrophysics Data System (ADS)

Pagnoni, Gianluca; Tinti, Stefano

2017-04-01

The city of Augusta is located in the southern part of the eastern coast of Sicily. Italian tsunami catalogue and paleo-tsunami surveys indicate that at least 7 events of tsunami affected the bay of Augusta in the last 4,000 years, two of which are associated with earthquakes (1169 and 1693) that destroyed the city. For these reasons Augusta has been chosen in the project ASTARTE as a test site for the study of issues related to tsunami hazard and risk. In last two years we studied hazard through the approach of the worst-case credible scenario and carried out vulnerability and damage analysis for buildings. In this work, we integrate that research, and estimate the damage to people and the economic loss of buildings due to structural damage. As regards inundation, we assume both uniform inundation levels (bath-tub hypothesis) and inundation data resulting from the worst-case scenario elaborated for the area by Armigliato et al. (2015). Human damage is calculated in three steps using the method introduced by Pagnoni et al. (2016) following the work by Terrier et al. (2012) and by Koshimura et al. (2009). First, we use census data to estimate the number of people present in each residential building affected by inundation; second, based on water column depth and building type, we evaluate the level of damage to people; third, we provide an estimate of fatalities. The economic loss is computed for two types of buildings (residential and trade-industrial) by using data on inundation and data from the real estate market. This study was funded by the EU Project ASTARTE - "Assessment, STrategy And Risk Reduction for Tsunamis in Europe", Grant 603839, 7th FP (ENV.2013.6.4-3)

Worst-Case Flutter Margins from F/A-18 Aircraft Aeroelastic Data

NASA Technical Reports Server (NTRS)

Lind, Rick; Brenner, Marty

1997-01-01

An approach for computing worst-case flutter margins has been formulated in a robust stability framework. Uncertainty operators are included with a linear model to describe modeling errors and flight variations. The structured singular value, micron, computes a stability margin which directly accounts for these uncertainties. This approach introduces a new method of computing flutter margins and an associated new parameter for describing these margins. The micron margins are robust margins which indicate worst-case stability estimates with respect to the defined uncertainty. Worst-case flutter margins are computed for the F/A-18 SRA using uncertainty sets generated by flight data analysis. The robust margins demonstrate flight conditions for flutter may lie closer to the flight envelope than previously estimated by p-k analysis.

On the estimation of the worst-case implant-induced RF-heating in multi-channel MRI.

PubMed

Córcoles, Juan; Zastrow, Earl; Kuster, Niels

2017-06-21

The increasing use of multiple radiofrequency (RF) transmit channels in magnetic resonance imaging (MRI) systems makes it necessary to rigorously assess the risk of RF-induced heating. This risk is especially aggravated with inclusions of medical implants within the body. The worst-case RF-heating scenario is achieved when the local tissue deposition in the at-risk region (generally in the vicinity of the implant electrodes) reaches its maximum value while MRI exposure is compliant with predefined general specific absorption rate (SAR) limits or power requirements. This work first reviews the common approach to estimate the worst-case RF-induced heating in multi-channel MRI environment, based on the maximization of the ratio of two Hermitian forms by solving a generalized eigenvalue problem. It is then shown that the common approach is not rigorous and may lead to an underestimation of the worst-case RF-heating scenario when there is a large number of RF transmit channels and there exist multiple SAR or power constraints to be satisfied. Finally, this work derives a rigorous SAR-based formulation to estimate a preferable worst-case scenario, which is solved by casting a semidefinite programming relaxation of this original non-convex problem, whose solution closely approximates the true worst-case including all SAR constraints. Numerical results for 2, 4, 8, 16, and 32 RF channels in a 3T-MRI volume coil for a patient with a deep-brain stimulator under a head imaging exposure are provided as illustrative examples.

On the estimation of the worst-case implant-induced RF-heating in multi-channel MRI

NASA Astrophysics Data System (ADS)

Córcoles, Juan; Zastrow, Earl; Kuster, Niels

2017-06-01

The increasing use of multiple radiofrequency (RF) transmit channels in magnetic resonance imaging (MRI) systems makes it necessary to rigorously assess the risk of RF-induced heating. This risk is especially aggravated with inclusions of medical implants within the body. The worst-case RF-heating scenario is achieved when the local tissue deposition in the at-risk region (generally in the vicinity of the implant electrodes) reaches its maximum value while MRI exposure is compliant with predefined general specific absorption rate (SAR) limits or power requirements. This work first reviews the common approach to estimate the worst-case RF-induced heating in multi-channel MRI environment, based on the maximization of the ratio of two Hermitian forms by solving a generalized eigenvalue problem. It is then shown that the common approach is not rigorous and may lead to an underestimation of the worst-case RF-heating scenario when there is a large number of RF transmit channels and there exist multiple SAR or power constraints to be satisfied. Finally, this work derives a rigorous SAR-based formulation to estimate a preferable worst-case scenario, which is solved by casting a semidefinite programming relaxation of this original non-convex problem, whose solution closely approximates the true worst-case including all SAR constraints. Numerical results for 2, 4, 8, 16, and 32 RF channels in a 3T-MRI volume coil for a patient with a deep-brain stimulator under a head imaging exposure are provided as illustrative examples.

49 CFR 194.5 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... crosses a major river or other navigable waters, which, because of the velocity of the river flow and vessel traffic on the river, would require a more rapid response in case of a worst case discharge or..., because of its velocity and vessel traffic, would require a more rapid response in case of a worst case...

49 CFR 194.5 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... crosses a major river or other navigable waters, which, because of the velocity of the river flow and vessel traffic on the river, would require a more rapid response in case of a worst case discharge or..., because of its velocity and vessel traffic, would require a more rapid response in case of a worst case...

49 CFR 194.5 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... crosses a major river or other navigable waters, which, because of the velocity of the river flow and vessel traffic on the river, would require a more rapid response in case of a worst case discharge or..., because of its velocity and vessel traffic, would require a more rapid response in case of a worst case...

Selection of Thermal Worst-Case Orbits via Modified Efficient Global Optimization

NASA Technical Reports Server (NTRS)

Moeller, Timothy M.; Wilhite, Alan W.; Liles, Kaitlin A.

2014-01-01

Efficient Global Optimization (EGO) was used to select orbits with worst-case hot and cold thermal environments for the Stratospheric Aerosol and Gas Experiment (SAGE) III. The SAGE III system thermal model changed substantially since the previous selection of worst-case orbits (which did not use the EGO method), so the selections were revised to ensure the worst cases are being captured. The EGO method consists of first conducting an initial set of parametric runs, generated with a space-filling Design of Experiments (DoE) method, then fitting a surrogate model to the data and searching for points of maximum Expected Improvement (EI) to conduct additional runs. The general EGO method was modified by using a multi-start optimizer to identify multiple new test points at each iteration. This modification facilitates parallel computing and decreases the burden of user interaction when the optimizer code is not integrated with the model. Thermal worst-case orbits for SAGE III were successfully identified and shown by direct comparison to be more severe than those identified in the previous selection. The EGO method is a useful tool for this application and can result in computational savings if the initial Design of Experiments (DoE) is selected appropriately.

The Worst-Case Weighted Multi-Objective Game with an Application to Supply Chain Competitions.

PubMed

Qu, Shaojian; Ji, Ying

2016-01-01

In this paper, we propose a worst-case weighted approach to the multi-objective n-person non-zero sum game model where each player has more than one competing objective. Our "worst-case weighted multi-objective game" model supposes that each player has a set of weights to its objectives and wishes to minimize its maximum weighted sum objectives where the maximization is with respect to the set of weights. This new model gives rise to a new Pareto Nash equilibrium concept, which we call "robust-weighted Nash equilibrium". We prove that the robust-weighted Nash equilibria are guaranteed to exist even when the weight sets are unbounded. For the worst-case weighted multi-objective game with the weight sets of players all given as polytope, we show that a robust-weighted Nash equilibrium can be obtained by solving a mathematical program with equilibrium constraints (MPEC). For an application, we illustrate the usefulness of the worst-case weighted multi-objective game to a supply chain risk management problem under demand uncertainty. By the comparison with the existed weighted approach, we show that our method is more robust and can be more efficiently used for the real-world applications.

An SEU resistant 256K SOI SRAM

NASA Astrophysics Data System (ADS)

Hite, L. R.; Lu, H.; Houston, T. W.; Hurta, D. S.; Bailey, W. E.

1992-12-01

A novel SEU (single event upset) resistant SRAM (static random access memory) cell has been implemented in a 256K SOI (silicon on insulator) SRAM that has attractive performance characteristics over the military temperature range of -55 to +125 C. These include worst-case access time of 40 ns with an active power of only 150 mW at 25 MHz, and a worst-case minimum WRITE pulse width of 20 ns. Measured SEU performance gives an Adams 10 percent worst-case error rate of 3.4 x 10 exp -11 errors/bit-day using the CRUP code with a conservative first-upset LET threshold. Modeling does show that higher bipolar gain than that measured on a sample from the SRAM lot would produce a lower error rate. Measurements show the worst-case supply voltage for SEU to be 5.5 V. Analysis has shown this to be primarily caused by the drain voltage dependence of the beta of the SOI parasitic bipolar transistor. Based on this, SEU experiments with SOI devices should include measurements as a function of supply voltage, rather than the traditional 4.5 V, to determine the worst-case condition.

Efficacy and cost-efficacy of biologic therapies for moderate to severe psoriasis: a meta-analysis and cost-efficacy analysis using the intention-to-treat principle.

PubMed

Chi, Ching-Chi; Wang, Shu-Hui

2014-01-01

Compared to conventional therapies, biologics are more effective but expensive in treating psoriasis. To evaluate the efficacy and cost-efficacy of biologic therapies for psoriasis. We conducted a meta-analysis to calculate the efficacy of etanercept, adalimumab, infliximab, and ustekinumab for at least 75% reduction in the Psoriasis Area and Severity Index score (PASI 75) and Physician's Global Assessment clear/minimal (PGA 0/1). The cost-efficacy was assessed by calculating the incremental cost-effectiveness ratio (ICER) per subject achieving PASI 75 and PGA 0/1. The incremental efficacy regarding PASI 75 was 55% (95% confidence interval (95% CI) 38%-72%), 63% (95% CI 59%-67%), 71% (95% CI 67%-76%), 67% (95% CI 62%-73%), and 72% (95% CI 68%-75%) for etanercept, adalimumab, infliximab, and ustekinumab 45 mg and 90 mg, respectively. The corresponding 6-month ICER regarding PASI 75 was $32,643 (best case $24,936; worst case $47,246), $21,315 (best case $20,043; worst case $22,760), $27,782 (best case $25,954; worst case $29,440), $25,055 (best case $22,996; worst case $27,075), and $46,630 (best case $44,765; worst case $49,373), respectively. The results regarding PGA 0/1 were similar. Infliximab and ustekinumab 90 mg had the highest efficacy. Meanwhile, adalimumab had the best cost-efficacy, followed by ustekinumab 45 mg and infliximab.

R&M (Reliability and Maintainability) Program Cost Drivers.

DTIC Science & Technology

1987-05-01

Specific data points used to develop the models (i.e., labor hours mid associated systems and task application characteristics) were obtained from three...study data base used to generate the CER’s em be expanded by adding project data points to the input data given in Appendix 13, adjusting the CER...FRACAS, worst-case/ thermal analyses, stress screening and R-growth. However, the studies did not assign benefits to specific task areas. c. Task

30 CFR 254.47 - Determining the volume of oil of your worst case discharge scenario.

Code of Federal Regulations, 2011 CFR

2011-07-01

... associated with the facility. In determining the daily discharge rate, you must consider reservoir characteristics, casing/production tubing sizes, and historical production and reservoir pressure data. Your...) For exploratory or development drilling operations, the size of your worst case discharge scenario is...

SU-F-T-192: Study of Robustness Analysis Method of Multiple Field Optimized IMPT Plans for Head & Neck Patients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Y; Wang, X; Li, H

Purpose: Proton therapy is more sensitive to uncertainties than photon treatments due to protons’ finite range depending on the tissue density. Worst case scenario (WCS) method originally proposed by Lomax has been adopted in our institute for robustness analysis of IMPT plans. This work demonstrates that WCS method is sufficient enough to take into account of the uncertainties which could be encountered during daily clinical treatment. Methods: A fast and approximate dose calculation method is developed to calculate the dose for the IMPT plan under different setup and range uncertainties. Effects of two factors, inversed square factor and range uncertainty,more » are explored. WCS robustness analysis method was evaluated using this fast dose calculation method. The worst-case dose distribution was generated by shifting isocenter by 3 mm along x,y and z directions and modifying stopping power ratios by ±3.5%. 1000 randomly perturbed cases in proton range and x, yz directions were created and the corresponding dose distributions were calculated using this approximated method. DVH and dosimetric indexes of all 1000 perturbed cases were calculated and compared with the result using worst case scenario method. Results: The distributions of dosimetric indexes of 1000 perturbed cases were generated and compared with the results using worst case scenario. For D95 of CTVs, at least 97% of 1000 perturbed cases show higher values than the one of worst case scenario. For D5 of CTVs, at least 98% of perturbed cases have lower values than worst case scenario. Conclusion: By extensively calculating the dose distributions under random uncertainties, WCS method was verified to be reliable in evaluating the robustness level of MFO IMPT plans of H&N patients. The extensively sampling approach using fast approximated method could be used in evaluating the effects of different factors on the robustness level of IMPT plans in the future.« less

Effect of pesticide fate parameters and their uncertainty on the selection of 'worst-case' scenarios of pesticide leaching to groundwater.

PubMed

Vanderborght, Jan; Tiktak, Aaldrik; Boesten, Jos J T I; Vereecken, Harry

2011-03-01

For the registration of pesticides in the European Union, model simulations for worst-case scenarios are used to demonstrate that leaching concentrations to groundwater do not exceed a critical threshold. A worst-case scenario is a combination of soil and climate properties for which predicted leaching concentrations are higher than a certain percentile of the spatial concentration distribution within a region. The derivation of scenarios is complicated by uncertainty about soil and pesticide fate parameters. As the ranking of climate and soil property combinations according to predicted leaching concentrations is different for different pesticides, the worst-case scenario for one pesticide may misrepresent the worst case for another pesticide, which leads to 'scenario uncertainty'. Pesticide fate parameter uncertainty led to higher concentrations in the higher percentiles of spatial concentration distributions, especially for distributions in smaller and more homogeneous regions. The effect of pesticide fate parameter uncertainty on the spatial concentration distribution was small when compared with the uncertainty of local concentration predictions and with the scenario uncertainty. Uncertainty in pesticide fate parameters and scenario uncertainty can be accounted for using higher percentiles of spatial concentration distributions and considering a range of pesticides for the scenario selection. Copyright © 2010 Society of Chemical Industry.

The Worst-Case Weighted Multi-Objective Game with an Application to Supply Chain Competitions

PubMed Central

Qu, Shaojian; Ji, Ying

2016-01-01

In this paper, we propose a worst-case weighted approach to the multi-objective n-person non-zero sum game model where each player has more than one competing objective. Our “worst-case weighted multi-objective game” model supposes that each player has a set of weights to its objectives and wishes to minimize its maximum weighted sum objectives where the maximization is with respect to the set of weights. This new model gives rise to a new Pareto Nash equilibrium concept, which we call “robust-weighted Nash equilibrium”. We prove that the robust-weighted Nash equilibria are guaranteed to exist even when the weight sets are unbounded. For the worst-case weighted multi-objective game with the weight sets of players all given as polytope, we show that a robust-weighted Nash equilibrium can be obtained by solving a mathematical program with equilibrium constraints (MPEC). For an application, we illustrate the usefulness of the worst-case weighted multi-objective game to a supply chain risk management problem under demand uncertainty. By the comparison with the existed weighted approach, we show that our method is more robust and can be more efficiently used for the real-world applications. PMID:26820512

30 CFR 254.47 - Determining the volume of oil of your worst case discharge scenario.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the daily discharge rate, you must consider reservoir characteristics, casing/production tubing sizes, and historical production and reservoir pressure data. Your scenario must discuss how to respond to... drilling operations, the size of your worst case discharge scenario is the daily volume possible from an...

Impact of respiratory motion on worst-case scenario optimized intensity modulated proton therapy for lung cancers.

PubMed

Liu, Wei; Liao, Zhongxing; Schild, Steven E; Liu, Zhong; Li, Heng; Li, Yupeng; Park, Peter C; Li, Xiaoqiang; Stoker, Joshua; Shen, Jiajian; Keole, Sameer; Anand, Aman; Fatyga, Mirek; Dong, Lei; Sahoo, Narayan; Vora, Sujay; Wong, William; Zhu, X Ronald; Bues, Martin; Mohan, Radhe

2015-01-01

We compared conventionally optimized intensity modulated proton therapy (IMPT) treatment plans against worst-case scenario optimized treatment plans for lung cancer. The comparison of the 2 IMPT optimization strategies focused on the resulting plans' ability to retain dose objectives under the influence of patient setup, inherent proton range uncertainty, and dose perturbation caused by respiratory motion. For each of the 9 lung cancer cases, 2 treatment plans were created that accounted for treatment uncertainties in 2 different ways. The first used the conventional method: delivery of prescribed dose to the planning target volume that is geometrically expanded from the internal target volume (ITV). The second used a worst-case scenario optimization scheme that addressed setup and range uncertainties through beamlet optimization. The plan optimality and plan robustness were calculated and compared. Furthermore, the effects on dose distributions of changes in patient anatomy attributable to respiratory motion were investigated for both strategies by comparing the corresponding plan evaluation metrics at the end-inspiration and end-expiration phase and absolute differences between these phases. The mean plan evaluation metrics of the 2 groups were compared with 2-sided paired Student t tests. Without respiratory motion considered, we affirmed that worst-case scenario optimization is superior to planning target volume-based conventional optimization in terms of plan robustness and optimality. With respiratory motion considered, worst-case scenario optimization still achieved more robust dose distributions to respiratory motion for targets and comparable or even better plan optimality (D95% ITV, 96.6% vs 96.1% [P = .26]; D5%- D95% ITV, 10.0% vs 12.3% [P = .082]; D1% spinal cord, 31.8% vs 36.5% [P = .035]). Worst-case scenario optimization led to superior solutions for lung IMPT. Despite the fact that worst-case scenario optimization did not explicitly account for respiratory motion, it produced motion-resistant treatment plans. However, further research is needed to incorporate respiratory motion into IMPT robust optimization. Copyright © 2015 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved.

Selection of Worst-Case Pesticide Leaching Scenarios for Pesticide Registration

NASA Astrophysics Data System (ADS)

Vereecken, H.; Tiktak, A.; Boesten, J.; Vanderborght, J.

2010-12-01

The use of pesticides, fertilizers and manure in intensive agriculture may have a negative impact on the quality of ground- and surface water resources. Legislative action has been undertaken in many countries to protect surface and groundwater resources from contamination by surface applied agrochemicals. Of particular concern are pesticides. The registration procedure plays an important role in the regulation of pesticide use in the European Union. In order to register a certain pesticide use, the notifier needs to prove that the use does not entail a risk of groundwater contamination. Therefore, leaching concentrations of the pesticide need to be assessed using model simulations for so called worst-case scenarios. In the current procedure, a worst-case scenario represents a parameterized pesticide fate model for a certain soil and a certain time series of weather conditions that tries to represent all relevant processes such as transient water flow, root water uptake, pesticide transport, sorption, decay and volatilisation as accurate as possible. Since this model has been parameterized for only one soil and weather time series, it is uncertain whether it represents a worst-case condition for a certain pesticide use. We discuss an alternative approach that uses a simpler model that requires less detailed information about the soil and weather conditions but still represents the effect of soil and climate on pesticide leaching using information that is available for the entire European Union. A comparison between the two approaches demonstrates that the higher precision that the detailed model provides for the prediction of pesticide leaching at a certain site is counteracted by its smaller accuracy to represent a worst case condition. The simpler model predicts leaching concentrations less precise at a certain site but has a complete coverage of the area so that it selects a worst-case condition more accurately.

A Framework to Improve Surgeon Communication in High-Stakes Surgical Decisions: Best Case/Worst Case.

PubMed

Taylor, Lauren J; Nabozny, Michael J; Steffens, Nicole M; Tucholka, Jennifer L; Brasel, Karen J; Johnson, Sara K; Zelenski, Amy; Rathouz, Paul J; Zhao, Qianqian; Kwekkeboom, Kristine L; Campbell, Toby C; Schwarze, Margaret L

2017-06-01

Although many older adults prefer to avoid burdensome interventions with limited ability to preserve their functional status, aggressive treatments, including surgery, are common near the end of life. Shared decision making is critical to achieve value-concordant treatment decisions and minimize unwanted care. However, communication in the acute inpatient setting is challenging. To evaluate the proof of concept of an intervention to teach surgeons to use the Best Case/Worst Case framework as a strategy to change surgeon communication and promote shared decision making during high-stakes surgical decisions. Our prospective pre-post study was conducted from June 2014 to August 2015, and data were analyzed using a mixed methods approach. The data were drawn from decision-making conversations between 32 older inpatients with an acute nonemergent surgical problem, 30 family members, and 25 surgeons at 1 tertiary care hospital in Madison, Wisconsin. A 2-hour training session to teach each study-enrolled surgeon to use the Best Case/Worst Case communication framework. We scored conversation transcripts using OPTION 5, an observer measure of shared decision making, and used qualitative content analysis to characterize patterns in conversation structure, description of outcomes, and deliberation over treatment alternatives. The study participants were patients aged 68 to 95 years (n = 32), 44% of whom had 5 or more comorbid conditions; family members of patients (n = 30); and surgeons (n = 17). The median OPTION 5 score improved from 41 preintervention (interquartile range, 26-66) to 74 after Best Case/Worst Case training (interquartile range, 60-81). Before training, surgeons described the patient's problem in conjunction with an operative solution, directed deliberation over options, listed discrete procedural risks, and did not integrate preferences into a treatment recommendation. After training, surgeons using Best Case/Worst Case clearly presented a choice between treatments, described a range of postoperative trajectories including functional decline, and involved patients and families in deliberation. Using the Best Case/Worst Case framework changed surgeon communication by shifting the focus of decision-making conversations from an isolated surgical problem to a discussion about treatment alternatives and outcomes. This intervention can help surgeons structure challenging conversations to promote shared decision making in the acute setting.

40 CFR 300.324 - Response to worst case discharges.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 28 2011-07-01 2011-07-01 false Response to worst case discharges. 300.324 Section 300.324 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION...

40 CFR 300.324 - Response to worst case discharges.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 29 2012-07-01 2012-07-01 false Response to worst case discharges. 300.324 Section 300.324 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION...

40 CFR 300.324 - Response to worst case discharges.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 29 2013-07-01 2013-07-01 false Response to worst case discharges. 300.324 Section 300.324 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION...

40 CFR 300.324 - Response to worst case discharges.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 28 2014-07-01 2014-07-01 false Response to worst case discharges. 300.324 Section 300.324 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION...

Electrical Evaluation of RCA MWS5001D Random Access Memory, Volume 1

NASA Technical Reports Server (NTRS)

Klute, A.

1979-01-01

Electrical characterization and qualification tests were performed on the RCA MWS5001D, 1024 by 1-bit, CMOS, random access memory. Characterization tests were performed on five devices. The tests included functional tests, AC parametric worst case pattern selection test, determination of worst-case transition for setup and hold times and a series of schmoo plots. The qualification tests were performed on 32 devices and included a 2000 hour burn in with electrical tests performed at 0 hours and after 168, 1000, and 2000 hours of burn in. The tests performed included functional tests and AC and DC parametric tests. All of the tests in the characterization phase, with the exception of the worst-case transition test, were performed at ambient temperatures of 25, -55 and 125 C. The worst-case transition test was performed at 25 C. The preburn in electrical tests were performed at 25, -55, and 125 C. All burn in endpoint tests were performed at 25, -40, -55, 85, and 125 C.

Reliability evaluation of high-performance, low-power FinFET standard cells based on mixed RBB/FBB technique

NASA Astrophysics Data System (ADS)

Wang, Tian; Cui, Xiaoxin; Ni, Yewen; Liao, Kai; Liao, Nan; Yu, Dunshan; Cui, Xiaole

2017-04-01

With shrinking transistor feature size, the fin-type field-effect transistor (FinFET) has become the most promising option in low-power circuit design due to its superior capability to suppress leakage. To support the VLSI digital system flow based on logic synthesis, we have designed an optimized high-performance low-power FinFET standard cell library based on employing the mixed FBB/RBB technique in the existing stacked structure of each cell. This paper presents the reliability evaluation of the optimized cells under process and operating environment variations based on Monte Carlo analysis. The variations are modelled with Gaussian distribution of the device parameters and 10000 sweeps are conducted in the simulation to obtain the statistical properties of the worst-case delay and input-dependent leakage for each cell. For comparison, a set of non-optimal cells that adopt the same topology without employing the mixed biasing technique is also generated. Experimental results show that the optimized cells achieve standard deviation reduction of 39.1% and 30.7% at most in worst-case delay and input-dependent leakage respectively while the normalized deviation shrinking in worst-case delay and input-dependent leakage can be up to 98.37% and 24.13%, respectively, which demonstrates that our optimized cells are less sensitive to variability and exhibit more reliability. Project supported by the National Natural Science Foundation of China (No. 61306040), the State Key Development Program for Basic Research of China (No. 2015CB057201), the Beijing Natural Science Foundation (No. 4152020), and Natural Science Foundation of Guangdong Province, China (No. 2015A030313147).

Query Optimization in Distributed Databases.

DTIC Science & Technology

1982-10-01

general, the strategy a31 a11 a 3 is more time comsuming than the strategy a, a, and sually we do not use it. Since the semijoin of R.XJ> RS requires...analytic behavior of those heuristic algorithms. Although some analytic results of worst case and average case analysis are difficult to obtain, some...is the study of the analytic behavior of those heuristic algorithms. Although some analytic results of worst case and average case analysis are

ANOTHER LOOK AT THE FAST ITERATIVE SHRINKAGE/THRESHOLDING ALGORITHM (FISTA)*

PubMed Central

Kim, Donghwan; Fessler, Jeffrey A.

2017-01-01

This paper provides a new way of developing the “Fast Iterative Shrinkage/Thresholding Algorithm (FISTA)” [3] that is widely used for minimizing composite convex functions with a nonsmooth term such as the ℓ1 regularizer. In particular, this paper shows that FISTA corresponds to an optimized approach to accelerating the proximal gradient method with respect to a worst-case bound of the cost function. This paper then proposes a new algorithm that is derived by instead optimizing the step coefficients of the proximal gradient method with respect to a worst-case bound of the composite gradient mapping. The proof is based on the worst-case analysis called Performance Estimation Problem in [11]. PMID:29805242

Conceptual modeling for identification of worst case conditions in environmental risk assessment of nanomaterials using nZVI and C60 as case studies.

PubMed

Grieger, Khara D; Hansen, Steffen F; Sørensen, Peter B; Baun, Anders

2011-09-01

Conducting environmental risk assessment of engineered nanomaterials has been an extremely challenging endeavor thus far. Moreover, recent findings from the nano-risk scientific community indicate that it is unlikely that many of these challenges will be easily resolved in the near future, especially given the vast variety and complexity of nanomaterials and their applications. As an approach to help optimize environmental risk assessments of nanomaterials, we apply the Worst-Case Definition (WCD) model to identify best estimates for worst-case conditions of environmental risks of two case studies which use engineered nanoparticles, namely nZVI in soil and groundwater remediation and C(60) in an engine oil lubricant. Results generated from this analysis may ultimately help prioritize research areas for environmental risk assessments of nZVI and C(60) in these applications as well as demonstrate the use of worst-case conditions to optimize future research efforts for other nanomaterials. Through the application of the WCD model, we find that the most probable worst-case conditions for both case studies include i) active uptake mechanisms, ii) accumulation in organisms, iii) ecotoxicological response mechanisms such as reactive oxygen species (ROS) production and cell membrane damage or disruption, iv) surface properties of nZVI and C(60), and v) acute exposure tolerance of organisms. Additional estimates of worst-case conditions for C(60) also include the physical location of C(60) in the environment from surface run-off, cellular exposure routes for heterotrophic organisms, and the presence of light to amplify adverse effects. Based on results of this analysis, we recommend the prioritization of research for the selected applications within the following areas: organism active uptake ability of nZVI and C(60) and ecotoxicological response end-points and response mechanisms including ROS production and cell membrane damage, full nanomaterial characterization taking into account detailed information on nanomaterial surface properties, and investigations of dose-response relationships for a variety of organisms. Copyright © 2011 Elsevier B.V. All rights reserved.

Reducing Probabilistic Weather Forecasts to the Worst-Case Scenario: Anchoring Effects

ERIC Educational Resources Information Center

Joslyn, Susan; Savelli, Sonia; Nadav-Greenberg, Limor

2011-01-01

Many weather forecast providers believe that forecast uncertainty in the form of the worst-case scenario would be useful for general public end users. We tested this suggestion in 4 studies using realistic weather-related decision tasks involving high winds and low temperatures. College undergraduates, given the statistical equivalent of the…

30 CFR 553.13 - How much OSFR must I demonstrate?

Code of Federal Regulations, 2014 CFR

2014-07-01

... OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Applicability and Amount of OSFR § 553.13... the following table: COF worst case oil-spill discharge volume Applicable amount of OSFR Over 1,000... worst case oil-spill discharge of 1,000 bbls or less if the Director notifies you in writing that the...

30 CFR 553.13 - How much OSFR must I demonstrate?

Code of Federal Regulations, 2012 CFR

2012-07-01

... OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Applicability and Amount of OSFR § 553.13... the following table: COF worst case oil-spill discharge volume Applicable amount of OSFR Over 1,000... worst case oil-spill discharge of 1,000 bbls or less if the Director notifies you in writing that the...

30 CFR 553.13 - How much OSFR must I demonstrate?

Code of Federal Regulations, 2013 CFR

2013-07-01

... OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Applicability and Amount of OSFR § 553.13... the following table: COF worst case oil-spill discharge volume Applicable amount of OSFR Over 1,000... worst case oil-spill discharge of 1,000 bbls or less if the Director notifies you in writing that the...

Parallel transmission pulse design with explicit control for the specific absorption rate in the presence of radiofrequency errors.

PubMed

Martin, Adrian; Schiavi, Emanuele; Eryaman, Yigitcan; Herraiz, Joaquin L; Gagoski, Borjan; Adalsteinsson, Elfar; Wald, Lawrence L; Guerin, Bastien

2016-06-01

A new framework for the design of parallel transmit (pTx) pulses is presented introducing constraints for local and global specific absorption rate (SAR) in the presence of errors in the radiofrequency (RF) transmit chain. The first step is the design of a pTx RF pulse with explicit constraints for global and local SAR. Then, the worst possible SAR associated with that pulse due to RF transmission errors ("worst-case SAR") is calculated. Finally, this information is used to re-calculate the pulse with lower SAR constraints, iterating this procedure until its worst-case SAR is within safety limits. Analysis of an actual pTx RF transmit chain revealed amplitude errors as high as 8% (20%) and phase errors above 3° (15°) for spokes (spiral) pulses. Simulations show that using the proposed framework, pulses can be designed with controlled "worst-case SAR" in the presence of errors of this magnitude at minor cost of the excitation profile quality. Our worst-case SAR-constrained pTx design strategy yields pulses with local and global SAR within the safety limits even in the presence of RF transmission errors. This strategy is a natural way to incorporate SAR safety factors in the design of pTx pulses. Magn Reson Med 75:2493-2504, 2016. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

41 CFR 102-80.150 - What is meant by “reasonable worst case fire scenario”?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What is meant by âreasonable worst case fire scenarioâ? 102-80.150 Section 102-80.150 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 80...

40 CFR Appendix D to Part 112 - Determination of a Worst Case Discharge Planning Volume

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 23 2013-07-01 2013-07-01 false Determination of a Worst Case Discharge Planning Volume D Appendix D to Part 112 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION Pt. 112, App. D Appendix D to Part 112—Determination of a...

40 CFR Appendix D to Part 112 - Determination of a Worst Case Discharge Planning Volume

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Determination of a Worst Case Discharge Planning Volume D Appendix D to Part 112 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION Pt. 112, App. D Appendix D to Part 112—Determination of a...

40 CFR Appendix D to Part 112 - Determination of a Worst Case Discharge Planning Volume

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Determination of a Worst Case Discharge Planning Volume D Appendix D to Part 112 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION Pt. 112, App. D Appendix D to Part 112—Determination of a...

40 CFR Appendix D to Part 112 - Determination of a Worst Case Discharge Planning Volume

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Determination of a Worst Case Discharge Planning Volume D Appendix D to Part 112 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION Pt. 112, App. D Appendix D to Part 112—Determination of a...

40 CFR Appendix D to Part 112 - Determination of a Worst Case Discharge Planning Volume

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Determination of a Worst Case Discharge Planning Volume D Appendix D to Part 112 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION Pt. 112, App. D Appendix D to Part 112—Determination of a...

41 CFR 102-80.150 - What is meant by “reasonable worst case fire scenario”?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What is meant by âreasonable worst case fire scenarioâ? 102-80.150 Section 102-80.150 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 80...

Robust Flutter Margin Analysis that Incorporates Flight Data

NASA Technical Reports Server (NTRS)

Lind, Rick; Brenner, Martin J.

1998-01-01

An approach for computing worst-case flutter margins has been formulated in a robust stability framework. Uncertainty operators are included with a linear model to describe modeling errors and flight variations. The structured singular value, mu, computes a stability margin that directly accounts for these uncertainties. This approach introduces a new method of computing flutter margins and an associated new parameter for describing these margins. The mu margins are robust margins that indicate worst-case stability estimates with respect to the defined uncertainty. Worst-case flutter margins are computed for the F/A-18 Systems Research Aircraft using uncertainty sets generated by flight data analysis. The robust margins demonstrate flight conditions for flutter may lie closer to the flight envelope than previously estimated by p-k analysis.

Pacific Walrus and climate change: observations and predictions

PubMed Central

MacCracken, James G

2012-01-01

The extent and duration of sea-ice habitats used by Pacific walrus (Odobenus rosmarus divergens) are diminishing resulting in altered walrus behavior, mortality, and distribution. I document changes that have occurred over the past several decades and make predictions to the end of the 21st century. Climate models project that sea ice will monotonically decline resulting in more ice-free summers of longer duration. Several stressors that may impact walruses are directly influenced by sea ice. How these stressors materialize were modeled as most likely-case, worst-case, and best-case scenarios for the mid- and late-21st century, resulting in four comprehensive working hypotheses that can help identify and prioritize management and research projects, identify comprehensive mitigation actions, and guide monitoring programs to track future developments and adjust programs as needed. In the short term, the most plausible hypotheses predict a continuing northward shift in walrus distribution, increasing use of coastal haulouts in summer and fall, and a population reduction set by the carrying capacity of the near shore environment and subsistence hunting. Alternatively, under worst-case conditions, the population will decline to a level where the probability of extinction is high. In the long term, walrus may seasonally abandon the Bering and Chukchi Seas for sea-ice refugia to the northwest and northeast, ocean warming and pH decline alter walrus food resources, and subsistence hunting exacerbates a large population decline. However, conditions that reverse current trends in sea ice loss cannot be ruled out. Which hypothesis comes to fruition depends on how the stressors develop and the success of mitigation measures. Best-case scenarios indicate that successful mitigation of unsustainable harvests and terrestrial haulout-related mortalities can be effective. Management and research should focus on monitoring, elucidating effects, and mitigation, while ultimately, reductions in greenhouse gas emissions are needed to reduce sea-ice habitat losses. PMID:22957206

Hot-spot investigations of utility scale panel configurations

NASA Technical Reports Server (NTRS)

Arnett, J. C.; Dally, R. B.; Rumburg, J. P.

1984-01-01

The causes of array faults and efforts to mitigate their effects are examined. Research is concentrated on the panel for the 900 kw second phase of the Sacramento Municipal Utility District (SMUD) project. The panel is designed for hot spot tolerance without comprising efficiency under normal operating conditions. Series/paralleling internal to each module improves tolerance in the power quadrant to cell short or open circuits. Analtyical methods are developed for predicting worst case shade patterns and calculating the resultant cell temperature. Experiments conducted on a prototype panel support the analytical calculations.

Less than severe worst case accidents

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sanders, G.A.

1996-08-01

Many systems can provide tremendous benefit if operating correctly, produce only an inconvenience if they fail to operate, but have extreme consequences if they are only partially disabled such that they operate erratically or prematurely. In order to assure safety, systems are often tested against the most severe environments and accidents that are considered possible to ensure either safe operation or safe failure. However, it is often the less severe environments which result in the ``worst case accident`` since these are the conditions in which part of the system may be exposed or rendered unpredictable prior to total system failure.more » Some examples of less severe mechanical, thermal, and electrical environments which may actually be worst case are described as cautions for others in industries with high consequence operations or products.« less

Integrated Optoelectronic Networks for Application-Driven Multicore Computing

DTIC Science & Technology

2017-05-08

hybrid photonic torus, the all-optical Corona crossbar, and the hybrid hierarchical Firefly crossbar. • The key challenges for waveguide photonics...improves SXR but with relatively higher EDP overhead. Our evaluation results indicate that the encoding schemes improve worst-case-SXR in Corona and...photonic crossbar architectures ( Corona and Firefly) indicate that our approach improves worst-case signal-to-noise ratio (SNR) by up to 51.7

Method of Generating Transient Equivalent Sink and Test Target Temperatures for Swift BAT

NASA Technical Reports Server (NTRS)

Choi, Michael K.

2004-01-01

The NASA Swift mission has a 600-km altitude and a 22 degrees maximum inclination. The sun angle varies from 45 degrees to 180 degrees in normal operation. As a result, environmental heat fluxes absorbed by the Burst Alert Telescope (BAT) radiator and loop heat pipe (LHP) compensation chambers (CCs) vary transiently. Therefore the equivalent sink temperatures for the radiator and CCs varies transiently. In thermal performance verification testing in vacuum, the radiator and CCs radiated heat to sink targets. This paper presents an analytical technique for generating orbit transient equivalent sink temperatures and a technique for generating transient sink target temperatures for the radiator and LHP CCs. Using these techniques, transient target temperatures for the radiator and LHP CCs were generated for three thermal environmental cases: worst hot case, worst cold case, and cooldown and warmup between worst hot case in sunlight and worst cold case in the eclipse, and three different heat transport values: 128 W, 255 W, and 382 W. The 128 W case assumed that the two LHPs transport 255 W equally to the radiator. The 255 W case assumed that one LHP fails so that the remaining LHP transports all the waste heat from the detector array to the radiator. The 382 W case assumed that one LHP fails so that the remaining LHP transports all the waste heat from the detector array to the radiator, and has a 50% design margin. All these transient target temperatures were successfully implemented in the engineering test unit (ETU) LHP and flight LHP thermal performance verification tests in vacuum.

Defense Small Business Innovation Research Program (SBIR), Volume 4, Defense Agencies Abstracts of Phase 1 Awards 1991

DTIC Science & Technology

1991-01-01

EXPERIENCE IN DEVELOPING INTEGRATED OPTICAL DEVICES, NONLINEAR MAGNETIC-OPTIC MATERIALS, HIGH FREQUENCY MODULATORS, COMPUTER-AIDED MODELING AND SOPHISTICATED... HIGH -LEVEL PRESENTATION AND DISTRIBUTED CONTROL MODELS FOR INTEGRATING HETEROGENEOUS MECHANICAL ENGINEERING APPLICATIONS AND TOOLS. THE DESIGN IS FOCUSED...STATISTICALLY ACCURATE WORST CASE DEVICE MODELS FOR CIRCUIT SIMULATION. PRESENT METHODS OF WORST CASE DEVICE DESIGN ARE AD HOC AND DO NOT ALLOW THE

Inflated Uncertainty in Multimodel-Based Regional Climate Projections.

PubMed

Madsen, Marianne Sloth; Langen, Peter L; Boberg, Fredrik; Christensen, Jens Hesselbjerg

2017-11-28

Multimodel ensembles are widely analyzed to estimate the range of future regional climate change projections. For an ensemble of climate models, the result is often portrayed by showing maps of the geographical distribution of the multimodel mean results and associated uncertainties represented by model spread at the grid point scale. Here we use a set of CMIP5 models to show that presenting statistics this way results in an overestimation of the projected range leading to physically implausible patterns of change on global but also on regional scales. We point out that similar inconsistencies occur in impact analyses relying on multimodel information extracted using statistics at the regional scale, for example, when a subset of CMIP models is selected to represent regional model spread. Consequently, the risk of unwanted impacts may be overestimated at larger scales as climate change impacts will never be realized as the worst (or best) case everywhere.

Local measles vaccination gaps in Germany and the role of vaccination providers.

PubMed

Eichner, Linda; Wjst, Stephanie; Brockmann, Stefan O; Wolfers, Kerstin; Eichner, Martin

2017-08-14

Measles elimination in Europe is an urgent public health goal, yet despite the efforts of its member states, vaccination gaps and outbreaks occur. This study explores local vaccination heterogeneity in kindergartens and municipalities of a German county. Data on children from mandatory school enrolment examinations in 2014/15 in Reutlingen county were used. Children with unknown vaccination status were either removed from the analysis (best case) or assumed to be unvaccinated (worst case). Vaccination data were translated into expected outbreak probabilities. Physicians and kindergartens with statistically outstanding numbers of under-vaccinated children were identified. A total of 170 (7.1%) of 2388 children did not provide a vaccination certificate; 88.3% (worst case) or 95.1% (best case) were vaccinated at least once against measles. Based on the worst case vaccination coverage, <10% of municipalities and <20% of kindergartens were sufficiently vaccinated to be protected against outbreaks. Excluding children without a vaccination certificate (best case) leads to over-optimistic views: the overall outbreak probability in case of a measles introduction lies between 39.5% (best case) and 73.0% (worst case). Four paediatricians were identified who accounted for 41 of 109 unvaccinated children and for 47 of 138 incomplete vaccinations; GPs showed significantly higher rates of missing vaccination certificates and unvaccinated or under-vaccinated children than paediatricians. Missing vaccination certificates pose a severe problem regarding the interpretability of vaccination data. Although the coverage for at least one measles vaccination is higher in the studied county than in most South German counties and higher than the European average, many severe and potentially dangerous vaccination gaps occur locally. If other federal German states and EU countries show similar vaccination variability, measles elimination may not succeed in Europe.

6 Project-Management Tips

ERIC Educational Resources Information Center

Demski, Jennifer

2012-01-01

When it comes to project management, the IT department is typically its own worst enemy. When project requests are pushed through the budgeting process by different departments, it's up to IT to make them all work. The staff is required to be "heroic" to get the project load done. People get to work over weekends and postpone their vacations. The…

Worst case estimation of homology design by convex analysis

NASA Technical Reports Server (NTRS)

Yoshikawa, N.; Elishakoff, Isaac; Nakagiri, S.

1998-01-01

The methodology of homology design is investigated for optimum design of advanced structures. for which the achievement of delicate tasks by the aid of active control system is demanded. The proposed formulation of homology design, based on the finite element sensitivity analysis, necessarily requires the specification of external loadings. The formulation to evaluate the worst case for homology design caused by uncertain fluctuation of loadings is presented by means of the convex model of uncertainty, in which uncertainty variables are assigned to discretized nodal forces and are confined within a conceivable convex hull given as a hyperellipse. The worst case of the distortion from objective homologous deformation is estimated by the Lagrange multiplier method searching the point to maximize the error index on the boundary of the convex hull. The validity of the proposed method is demonstrated in a numerical example using the eleven-bar truss structure.

Biomechanical behavior of a cemented ceramic knee replacement under worst case scenarios

NASA Astrophysics Data System (ADS)

Kluess, D.; Mittelmeier, W.; Bader, R.

2009-12-01

In connection with technological advances in the manufacturing of medical ceramics, a newly developed ceramic femoral component was introduced in total knee arthroplasty (TKA). The motivation to consider ceramics in TKA is based on the allergological and tribological benefits as proven in total hip arthroplasty. Owing to the brittleness and reduced fracture toughness of ceramic materials, the biomechanical performance has to be examined intensely. Apart from standard testing, we calculated the implant performance under different worst case scenarios including malposition, bone defects and stumbling. A finite-element-model was developed to calculate the implant performance in situ. The worst case conditions revealed principal stresses 12.6 times higher during stumbling than during normal gait. Nevertheless, none of the calculated principal stress amounts were above the critical strength of the ceramic material used. The analysis of malposition showed the necessity of exact alignment of the implant components.

Biomechanical behavior of a cemented ceramic knee replacement under worst case scenarios

NASA Astrophysics Data System (ADS)

Kluess, D.; Mittelmeier, W.; Bader, R.

2010-03-01

In connection with technological advances in the manufacturing of medical ceramics, a newly developed ceramic femoral component was introduced in total knee arthroplasty (TKA). The motivation to consider ceramics in TKA is based on the allergological and tribological benefits as proven in total hip arthroplasty. Owing to the brittleness and reduced fracture toughness of ceramic materials, the biomechanical performance has to be examined intensely. Apart from standard testing, we calculated the implant performance under different worst case scenarios including malposition, bone defects and stumbling. A finite-element-model was developed to calculate the implant performance in situ. The worst case conditions revealed principal stresses 12.6 times higher during stumbling than during normal gait. Nevertheless, none of the calculated principal stress amounts were above the critical strength of the ceramic material used. The analysis of malposition showed the necessity of exact alignment of the implant components.

Migration of mineral oil from party plates of recycled paperboard into foods: 1. Is recycled paperboard fit for the purpose? 2. Adequate testing procedure.

PubMed

Dima, Giovanna; Verzera, Antonella; Grob, Koni

2011-11-01

Party plates made of recycled paperboard with a polyolefin film on the food contact surface (more often polypropylene than polyethylene) were tested for migration of mineral oil into various foods applying reasonable worst case conditions. The worst case was identified as a slice of fried meat placed onto the plate while hot and allowed to cool for 1 h. As it caused the acceptable daily intake (ADI) specified by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) to be exceeded, it is concluded that recycled paperboard is generally acceptable for party plates only when separated from the food by a functional barrier. Migration data obtained with oil as simulant at 70°C was compared to the migration into foods. A contact time of 30 min was found to reasonably cover the worst case determined in food.

Telemetry data storage systems technology for the Space Station Freedom era

NASA Technical Reports Server (NTRS)

Dalton, John T.

1989-01-01

This paper examines the requirements and functions of the telemetry-data recording and storage systems, and the data-storage-system technology projected for the Space Station, with particular attention given to the Space Optical Disk Recorder, an on-board storage subsystem based on 160 gigabit erasable optical disk units each capable of operating at 300 M bits per second. Consideration is also given to storage systems for ground transport recording, which include systems for data capture, buffering, processing, and delivery on the ground. These can be categorized as the first in-first out storage, the fast random-access storage, and the slow access with staging. Based on projected mission manifests and data rates, the worst case requirements were developed for these three storage architecture functions. The results of the analysis are presented.

The effect of a loss of model structural detail due to network skeletonization on contamination warning system design: case studies.

PubMed

Davis, Michael J; Janke, Robert

2018-01-04

The effect of limitations in the structural detail available in a network model on contamination warning system (CWS) design was examined in case studies using the original and skeletonized network models for two water distribution systems (WDSs). The skeletonized models were used as proxies for incomplete network models. CWS designs were developed by optimizing sensor placements for worst-case and mean-case contamination events. Designs developed using the skeletonized network models were transplanted into the original network model for evaluation. CWS performance was defined as the number of people who ingest more than some quantity of a contaminant in tap water before the CWS detects the presence of contamination. Lack of structural detail in a network model can result in CWS designs that (1) provide considerably less protection against worst-case contamination events than that obtained when a more complete network model is available and (2) yield substantial underestimates of the consequences associated with a contamination event. Nevertheless, CWSs developed using skeletonized network models can provide useful reductions in consequences for contaminants whose effects are not localized near the injection location. Mean-case designs can yield worst-case performances similar to those for worst-case designs when there is uncertainty in the network model. Improvements in network models for WDSs have the potential to yield significant improvements in CWS designs as well as more realistic evaluations of those designs. Although such improvements would be expected to yield improved CWS performance, the expected improvements in CWS performance have not been quantified previously. The results presented here should be useful to those responsible for the design or implementation of CWSs, particularly managers and engineers in water utilities, and encourage the development of improved network models.

The effect of a loss of model structural detail due to network skeletonization on contamination warning system design: case studies

NASA Astrophysics Data System (ADS)

Davis, Michael J.; Janke, Robert

2018-05-01

The effect of limitations in the structural detail available in a network model on contamination warning system (CWS) design was examined in case studies using the original and skeletonized network models for two water distribution systems (WDSs). The skeletonized models were used as proxies for incomplete network models. CWS designs were developed by optimizing sensor placements for worst-case and mean-case contamination events. Designs developed using the skeletonized network models were transplanted into the original network model for evaluation. CWS performance was defined as the number of people who ingest more than some quantity of a contaminant in tap water before the CWS detects the presence of contamination. Lack of structural detail in a network model can result in CWS designs that (1) provide considerably less protection against worst-case contamination events than that obtained when a more complete network model is available and (2) yield substantial underestimates of the consequences associated with a contamination event. Nevertheless, CWSs developed using skeletonized network models can provide useful reductions in consequences for contaminants whose effects are not localized near the injection location. Mean-case designs can yield worst-case performances similar to those for worst-case designs when there is uncertainty in the network model. Improvements in network models for WDSs have the potential to yield significant improvements in CWS designs as well as more realistic evaluations of those designs. Although such improvements would be expected to yield improved CWS performance, the expected improvements in CWS performance have not been quantified previously. The results presented here should be useful to those responsible for the design or implementation of CWSs, particularly managers and engineers in water utilities, and encourage the development of improved network models.

Control of Ebola hemorrhagic fever: vaccine development and our Ebola project in Sierra Leone.

PubMed

Watanabe, Tokiko; Kawaoka, Yoshihiro

2016-01-01

Since December 2013, West Africa has experienced the worst Ebola virus outbreak in recorded history. Of the 28,639 cases reported to the World Health Organization as of March 2016, nearly half (14,124) occurred in Sierra Leone. With a case fatality rate of approximately 40%, this outbreak has claimed the lives of 11,316 individuals. No FDA-approved vaccines or drugs are available to prevent or treat Ebola virus infection. Experimental vaccines and therapies are being developed; however, their safety and efficacy are still being evaluated. Therefore, there is an urgent need to develop control measures to prevent or limit future Ebola virus outbreaks.Previously, we developed a replication-defective Ebola virus that lacks the coding region for the essential viral transcription activator VP30 (Ebola ΔVP30 virus). Here, we evaluated the vaccine efficacy of Ebola ΔVP30 virus in a non-human primate model and describe our collaborative Ebola project in Sierra Leone.

Sensitivity of worst-case strom surge considering influence of climate change

NASA Astrophysics Data System (ADS)

Takayabu, Izuru; Hibino, Kenshi; Sasaki, Hidetaka; Shiogama, Hideo; Mori, Nobuhito; Shibutani, Yoko; Takemi, Tetsuya

2016-04-01

There are two standpoints when assessing risk caused by climate change. One is how to prevent disaster. For this purpose, we get probabilistic information of meteorological elements, from enough number of ensemble simulations. Another one is to consider disaster mitigation. For this purpose, we have to use very high resolution sophisticated model to represent a worst case event in detail. If we could use enough computer resources to drive many ensemble runs with very high resolution model, we can handle these all themes in one time. However resources are unfortunately limited in most cases, and we have to select the resolution or the number of simulations if we design the experiment. Applying PGWD (Pseudo Global Warming Downscaling) method is one solution to analyze a worst case event in detail. Here we introduce an example to find climate change influence on the worst case storm-surge, by applying PGWD to a super typhoon Haiyan (Takayabu et al, 2015). 1 km grid WRF model could represent both the intensity and structure of a super typhoon. By adopting PGWD method, we can only estimate the influence of climate change on the development process of the Typhoon. Instead, the changes in genesis could not be estimated. Finally, we drove SU-WAT model (which includes shallow water equation model) to get the signal of storm surge height. The result indicates that the height of the storm surge increased up to 20% owing to these 150 years climate change.

Lifetime Prevalence of Posttraumatic Stress Disorder in Two American Indian Reservation Populations

PubMed Central

Beals, Janette; Manson, Spero M.; Croy, Calvin; Klein, Suzell A.; Whitesell, Nancy Rumbaugh; Mitchell, Christina M.

2015-01-01

Posttraumatic stress disorder (PTSD) has been found to be more common among American Indian populations than among other Americans. A complex diagnosis, the assessment methods for PTSD have varied across epidemiological studies, especially in terms of the trauma criteria. Here, we examined data from the American Indian Service Utilization, Psychiatric Epidemiology, Risk and Protective Factors Project (AI-SUPERPFP) to estimate the lifetime prevalence of PTSD in two culturally distinct American Indian reservation communities, using two formulas for calculating PTSD prevalence. The AI-SUPERPFP was a cross-sectional probability sample survey conducted between 1997 and 2000. Southwest (n = 1,446) and Northern Plains (n = 1,638) tribal members living on or near their reservations, aged 15–57 years at time of interview, were randomly sampled from tribal rolls. PTSD estimates were derived based on both the single worst and 3 worst traumas. Prevalence estimates varied by ascertainment method: single worst trauma (lifetime: 5.9% to 14.8%) versus 3 worst traumas (lifetime, 8.9% to 19.5%). Use of the 3-worst-event approach increased prevalence by 28.3% over the single-event method. PTSD was prevalent in these tribal communities. These results also serve to underscore the need to better understand the implications for PTSD prevalence with the current focus on a single worst event. PMID:23900893

Electrical Evaluation of RCA MWS5001D Random Access Memory, Volume 4, Appendix C

NASA Technical Reports Server (NTRS)

Klute, A.

1979-01-01

The electrical characterization and qualification test results are presented for the RCA MWS5001D random access memory. The tests included functional tests, AC and DC parametric tests, AC parametric worst-case pattern selection test, determination of worst-case transition for setup and hold times, and a series of schmoo plots. Statistical analysis data is supplied along with write pulse width, read cycle time, write cycle time, and chip enable time data.

Electrical Evaluation of RCA MWS5501D Random Access Memory, Volume 2, Appendix a

NASA Technical Reports Server (NTRS)

Klute, A.

1979-01-01

The electrical characterization and qualification test results are presented for the RCA MWS5001D random access memory. The tests included functional tests, AC and DC parametric tests, AC parametric worst-case pattern selection test, determination of worst-case transition for setup and hold times, and a series of schmoo plots. The address access time, address readout time, the data hold time, and the data setup time are some of the results surveyed.

Probabilistic Models for Solar Particle Events

NASA Technical Reports Server (NTRS)

Adams, James H., Jr.; Dietrich, W. F.; Xapsos, M. A.; Welton, A. M.

2009-01-01

Probabilistic Models of Solar Particle Events (SPEs) are used in space mission design studies to provide a description of the worst-case radiation environment that the mission must be designed to tolerate.The models determine the worst-case environment using a description of the mission and a user-specified confidence level that the provided environment will not be exceeded. This poster will focus on completing the existing suite of models by developing models for peak flux and event-integrated fluence elemental spectra for the Z>2 elements. It will also discuss methods to take into account uncertainties in the data base and the uncertainties resulting from the limited number of solar particle events in the database. These new probabilistic models are based on an extensive survey of SPE measurements of peak and event-integrated elemental differential energy spectra. Attempts are made to fit the measured spectra with eight different published models. The model giving the best fit to each spectrum is chosen and used to represent that spectrum for any energy in the energy range covered by the measurements. The set of all such spectral representations for each element is then used to determine the worst case spectrum as a function of confidence level. The spectral representation that best fits these worst case spectra is found and its dependence on confidence level is parameterized. This procedure creates probabilistic models for the peak and event-integrated spectra.

A Multidimensional Assessment of Children in Conflictual Contexts: The Case of Kenya

ERIC Educational Resources Information Center

Okech, Jane E. Atieno

2012-01-01

Children in Kenya's Kisumu District Primary Schools (N = 430) completed three measures of trauma. Respondents completed the "My Worst Experience Scale" (MWES; Hyman and Snook 2002) and its supplement, the "School Alienation and Trauma Survey" (SATS; Hyman and Snook 2002), sharing their worst experiences overall and specifically…

Projected impacts of climate change on environmental suitability for malaria transmission in West Africa.

PubMed

Yamana, Teresa K; Eltahir, Elfatih A B

2013-10-01

Climate change is expected to affect the distribution of environmental suitability for malaria transmission by altering temperature and rainfall patterns; however, the local and global impacts of climate change on malaria transmission are uncertain. We assessed the effect of climate change on malaria transmission in West Africa. We coupled a detailed mechanistic hydrology and entomology model with climate projections from general circulation models (GCMs) to predict changes in vectorial capacity, an indication of the risk of human malaria infections, resulting from changes in the availability of mosquito breeding sites and temperature-dependent development rates. Because there is strong disagreement in climate predictions from different GCMs, we focused on the GCM projections that produced the best and worst conditions for malaria transmission in each zone of the study area. Simulation-based estimates suggest that in the desert fringes of the Sahara, vectorial capacity would increase under the worst-case scenario, but not enough to sustain transmission. In the transitional zone of the Sahel, climate change is predicted to decrease vectorial capacity. In the wetter regions to the south, our estimates suggest an increase in vectorial capacity under all scenarios. However, because malaria is already highly endemic among human populations in these regions, we expect that changes in malaria incidence would be small. Our findings highlight the importance of rainfall in shaping the impact of climate change on malaria transmission in future climates. Even under the GCM predictions most conducive to malaria transmission, we do not expect to see a significant increase in malaria prevalence in this region.

DEVELOPMENT OF A LOW-COST INFERENTIAL NATURAL GAS ENERGY FLOW RATE PROTOTYPE RETROFIT MODULE

DOE Office of Scientific and Technical Information (OSTI.GOV)

E. Kelner; T.E. Owen; D.L. George

2004-03-01

In 1998, Southwest Research Institute{reg_sign} began a multi-year project co-funded by the Gas Research Institute (GRI) and the U.S. Department of Energy. The project goal is to develop a working prototype instrument module for natural gas energy measurement. The module will be used to retrofit a natural gas custody transfer flow meter for energy measurement, at a cost an order of magnitude lower than a gas chromatograph. Development and evaluation of the prototype retrofit natural gas energy flow meter in 2000-2001 included: (1) evaluation of the inferential gas energy analysis algorithm using supplemental gas databases and anticipated worst-case gas mixtures;more » (2) identification and feasibility review of potential sensing technologies for nitrogen diluent content; (3) experimental performance evaluation of infrared absorption sensors for carbon dioxide diluent content; and (4) procurement of a custom ultrasonic transducer and redesign of the ultrasonic pulse reflection correlation sensor for precision speed-of-sound measurements. A prototype energy meter module containing improved carbon dioxide and speed-of-sound sensors was constructed and tested in the GRI Metering Research Facility at SwRI. Performance of this module using transmission-quality natural gas and gas containing supplemental carbon dioxide up to 9 mol% resulted in gas energy determinations well within the inferential algorithm worst-case tolerance of {+-}2.4 Btu/scf (nitrogen diluent gas measured by gas chromatograph). A two-week field test was performed at a gas-fired power plant to evaluate the inferential algorithm and the data acquisition requirements needed to adapt the prototype energy meter module to practical field site conditions.« less

Worst-error analysis of batch filter and sequential filter in navigation problems. [in spacecraft trajectory estimation

NASA Technical Reports Server (NTRS)

Nishimura, T.

1975-01-01

This paper proposes a worst-error analysis for dealing with problems of estimation of spacecraft trajectories in deep space missions. Navigation filters in use assume either constant or stochastic (Markov) models for their estimated parameters. When the actual behavior of these parameters does not follow the pattern of the assumed model, the filters sometimes result in very poor performance. To prepare for such pathological cases, the worst errors of both batch and sequential filters are investigated based on the incremental sensitivity studies of these filters. By finding critical switching instances of non-gravitational accelerations, intensive tracking can be carried out around those instances. Also the worst errors in the target plane provide a measure in assignment of the propellant budget for trajectory corrections. Thus the worst-error study presents useful information as well as practical criteria in establishing the maneuver and tracking strategy of spacecraft's missions.

Avoiding verisimilitude when modelling ecological responses to climate change: the influence of weather conditions on trapping efficiency in European badgers (Meles meles).

PubMed

Noonan, Michael J; Rahman, M Abidur; Newman, Chris; Buesching, Christina D; Macdonald, David W

2015-10-01

The signal for climate change effects can be abstruse; consequently, interpretations of evidence must avoid verisimilitude, or else misattribution of causality could compromise policy decisions. Examining climatic effects on wild animal population dynamics requires ability to trap, observe or photograph and to recapture study individuals consistently. In this regard, we use 19 years of data (1994-2012), detailing the life histories on 1179 individual European badgers over 3288 (re-) trapping events, to test whether trapping efficiency was associated with season, weather variables (both contemporaneous and time lagged), body-condition index (BCI) and trapping efficiency (TE). PCA factor loadings demonstrated that TE was affected significantly by temperature and precipitation, as well as time lags in these variables. From multi-model inference, BCI was the principal driver of TE, where badgers in good condition were less likely to be trapped. Our analyses exposed that this was enacted mechanistically via weather variables driving BCI, affecting TE. Notably, the very conditions that militated for poor trapping success have been associated with actual survival and population abundance benefits in badgers. Using these findings to parameterize simulations, projecting best-/worst-case scenario weather conditions and BCI resulted in 8.6% ± 4.9 SD difference in seasonal TE, leading to a potential 55.0% population abundance under-estimation under the worst-case scenario; 38.6% over-estimation under the best case. Interestingly, simulations revealed that while any single trapping session might prove misrepresentative of the true population abundance, due to weather effects, prolonging capture-mark-recapture studies under sub-optimal conditions decreased the accuracy of population estimates significantly. We also use these projection scenarios to explore how weather could impact government-led trapping of badgers in the UK, in relation to TB management. We conclude that population monitoring must be calibrated against the likelihood that weather conditions could be altering trap success directly, and therefore biasing model design. © 2015 John Wiley & Sons Ltd.

Experimental measurement of preferences in health and healthcare using best-worst scaling: an overview.

PubMed

Mühlbacher, Axel C; Kaczynski, Anika; Zweifel, Peter; Johnson, F Reed

2016-12-01

Best-worst scaling (BWS), also known as maximum-difference scaling, is a multiattribute approach to measuring preferences. BWS aims at the analysis of preferences regarding a set of attributes, their levels or alternatives. It is a stated-preference method based on the assumption that respondents are capable of making judgments regarding the best and the worst (or the most and least important, respectively) out of three or more elements of a choice-set. As is true of discrete choice experiments (DCE) generally, BWS avoids the known weaknesses of rating and ranking scales while holding the promise of generating additional information by making respondents choose twice, namely the best as well as the worst criteria. A systematic literature review found 53 BWS applications in health and healthcare. This article expounds possibilities of application, the underlying theoretical concepts and the implementation of BWS in its three variants: 'object case', 'profile case', 'multiprofile case'. This paper contains a survey of BWS methods and revolves around study design, experimental design, and data analysis. Moreover the article discusses the strengths and weaknesses of the three types of BWS distinguished and offered an outlook. A companion paper focuses on special issues of theory and statistical inference confronting BWS in preference measurement.

Job Prospects for Petroleum Engineers.

ERIC Educational Resources Information Center

Basta, Nicholas

1988-01-01

Describes petroleum engineering as one area in industry where job opportunities are few but where the worst of the declines has been seen. Discusses the causes of the decline. Lists several areas where petroleum engineers have found alternatives including environmental projects, water supply projects, and computer applications. (CW)

Effect of Impact Location on the Response of Shuttle Wing Leading Edge Panel 9

NASA Technical Reports Server (NTRS)

Lyle, Karen H.; Spellman, Regina L.; Hardy, Robin C.; Fasanella, Edwin L.; Jackson, Karen E.

2005-01-01

The objective of this paper is to compare the results of several simulations performed to determine the worst-case location for a foam impact on the Space Shuttle wing leading edge. The simulations were performed using the commercial non-linear transient dynamic finite element code, LS-DYNA. These simulations represent the first in a series of parametric studies performed to support the selection of the worst-case impact scenario. Panel 9 was selected for this study to enable comparisons with previous simulations performed during the Columbia Accident Investigation. The projectile for this study is a 5.5-in cube of typical external tank foam weighing 0.23 lb. Seven locations spanning the panel surface were impacted with the foam cube. For each of these cases, the foam was traveling at 1000 ft/s directly aft, along the orbiter X-axis. Results compared from the parametric studies included strains, contact forces, and material energies for various simulations. The results show that the worst case impact location was on the top surface, near the apex.

Phylogenetic diversity, functional trait diversity and extinction: avoiding tipping points and worst-case losses

PubMed Central

Faith, Daniel P.

2015-01-01

The phylogenetic diversity measure, (‘PD’), measures the relative feature diversity of different subsets of taxa from a phylogeny. At the level of feature diversity, PD supports the broad goal of biodiversity conservation to maintain living variation and option values. PD calculations at the level of lineages and features include those integrating probabilities of extinction, providing estimates of expected PD. This approach has known advantages over the evolutionarily distinct and globally endangered (EDGE) methods. Expected PD methods also have limitations. An alternative notion of expected diversity, expected functional trait diversity, relies on an alternative non-phylogenetic model and allows inferences of diversity at the level of functional traits. Expected PD also faces challenges in helping to address phylogenetic tipping points and worst-case PD losses. Expected PD may not choose conservation options that best avoid worst-case losses of long branches from the tree of life. We can expand the range of useful calculations based on expected PD, including methods for identifying phylogenetic key biodiversity areas. PMID:25561672

Space Environment Effects: Model for Emission of Solar Protons (ESP): Cumulative and Worst Case Event Fluences

NASA Technical Reports Server (NTRS)

Xapsos, M. A.; Barth, J. L.; Stassinopoulos, E. G.; Burke, E. A.; Gee, G. B.

1999-01-01

The effects that solar proton events have on microelectronics and solar arrays are important considerations for spacecraft in geostationary and polar orbits and for interplanetary missions. Designers of spacecraft and mission planners are required to assess the performance of microelectronic systems under a variety of conditions. A number of useful approaches exist for predicting information about solar proton event fluences and, to a lesser extent, peak fluxes. This includes the cumulative fluence over the course of a mission, the fluence of a worst-case event during a mission, the frequency distribution of event fluences, and the frequency distribution of large peak fluxes. Naval Research Laboratory (NRL) and NASA Goddard Space Flight Center, under the sponsorship of NASA's Space Environments and Effects (SEE) Program, have developed a new model for predicting cumulative solar proton fluences and worst-case solar proton events as functions of mission duration and user confidence level. This model is called the Emission of Solar Protons (ESP) model.

Space Environment Effects: Model for Emission of Solar Protons (ESP)--Cumulative and Worst-Case Event Fluences

NASA Technical Reports Server (NTRS)

Xapsos, M. A.; Barth, J. L.; Stassinopoulos, E. G.; Burke, Edward A.; Gee, G. B.

1999-01-01

The effects that solar proton events have on microelectronics and solar arrays are important considerations for spacecraft in geostationary and polar orbits and for interplanetary missions. Designers of spacecraft and mission planners are required to assess the performance of microelectronic systems under a variety of conditions. A number of useful approaches exist for predicting information about solar proton event fluences and, to a lesser extent, peak fluxes. This includes the cumulative fluence over the course of a mission, the fluence of a worst-case event during a mission, the frequency distribution of event fluences, and the frequency distribution of large peak fluxes. Naval Research Laboratory (NRL) and NASA Goddard Space Flight Center, under the sponsorship of NASA's Space Environments and Effects (SEE) Program, have developed a new model for predicting cumulative solar proton fluences and worst-case solar proton events as functions of mission duration and user confidence level. This model is called the Emission of Solar Protons (ESP) model.

Robust guaranteed-cost adaptive quantum phase estimation

NASA Astrophysics Data System (ADS)

Roy, Shibdas; Berry, Dominic W.; Petersen, Ian R.; Huntington, Elanor H.

2017-05-01

Quantum parameter estimation plays a key role in many fields like quantum computation, communication, and metrology. Optimal estimation allows one to achieve the most precise parameter estimates, but requires accurate knowledge of the model. Any inevitable uncertainty in the model parameters may heavily degrade the quality of the estimate. It is therefore desired to make the estimation process robust to such uncertainties. Robust estimation was previously studied for a varying phase, where the goal was to estimate the phase at some time in the past, using the measurement results from both before and after that time within a fixed time interval up to current time. Here, we consider a robust guaranteed-cost filter yielding robust estimates of a varying phase in real time, where the current phase is estimated using only past measurements. Our filter minimizes the largest (worst-case) variance in the allowable range of the uncertain model parameter(s) and this determines its guaranteed cost. It outperforms in the worst case the optimal Kalman filter designed for the model with no uncertainty, which corresponds to the center of the possible range of the uncertain parameter(s). Moreover, unlike the Kalman filter, our filter in the worst case always performs better than the best achievable variance for heterodyne measurements, which we consider as the tolerable threshold for our system. Furthermore, we consider effective quantum efficiency and effective noise power, and show that our filter provides the best results by these measures in the worst case.

Physical and composition characteristics of clinical secretions compared with test soils used for validation of flexible endoscope cleaning.

PubMed

Alfa, M J; Olson, N

2016-05-01

To determine which simulated-use test soils met the worst-case organic levels and viscosity of clinical secretions, and had the best adhesive characteristics. Levels of protein, carbohydrate and haemoglobin, and vibrational viscosity of clinical endoscope secretions were compared with test soils including ATS, ATS2015, Edinburgh, Edinburgh-M (modified), Miles, 10% serum and coagulated whole blood. ASTM D3359 was used for adhesion testing. Cleaning of a single-channel flexible intubation endoscope was tested after simulated use. The worst-case levels of protein, carbohydrate and haemoglobin, and viscosity of clinical material were 219,828μg/mL, 9296μg/mL, 9562μg/mL and 6cP, respectively. Whole blood, ATS2015 and Edinburgh-M were pipettable with viscosities of 3.4cP, 9.0cP and 11.9cP, respectively. ATS2015 and Edinburgh-M best matched the worst-case clinical parameters, but ATS had the best adhesion with 7% removal (36.7% for Edinburgh-M). Edinburgh-M and ATS2015 showed similar soiling and removal characteristics from the surface and lumen of a flexible intubation endoscope. Of the test soils evaluated, ATS2015 and Edinburgh-M were found to be good choices for the simulated use of endoscopes, as their composition and viscosity most closely matched worst-case clinical material. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Level II scour analysis for Bridge 38 (CONCTH00060038) on Town Highway 6, crossing the Moose River, Concord, Vermont

USGS Publications Warehouse

Olson, Scott A.

1996-01-01

Contraction scour for all modelled flows ranged from 0.1 to 3.1 ft. The worst-case contraction scour occurred at the incipient-overtopping discharge. Abutment scour at the left abutment ranged from 10.4 to 12.5 ft with the worst-case occurring at the 500-year discharge. Abutment scour at the right abutment ranged from 25.3 to 27.3 ft with the worst-case occurring at the incipient-overtopping discharge. The worst-case total scour also occurred at the incipient-overtopping discharge. The incipient-overtopping discharge was in between the 100- and 500-year discharges. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Evaluation of migration models that might be used in support of regulations for food-contact plastics.

PubMed

Begley, T; Castle, L; Feigenbaum, A; Franz, R; Hinrichs, K; Lickly, T; Mercea, P; Milana, M; O'Brien, A; Rebre, S; Rijk, R; Piringer, O

2005-01-01

Materials and articles intended to come into contact with food must be shown to be safe because they might interact with food during processing, storage and the transportation of foodstuffs. Framework Directive 89/109/EEC and its related specific Directives provide this safety basis for the protection of the consumer against inadmissible chemical contamination from food-contact materials. Recently, the European Commission charged an international group of experts to demonstrate that migration modelling can be regarded as a valid and reliable tool to calculate 'reasonable worst-case' migration rates from the most important food-contact plastics into the European Union official food simulants. The paper summarizes the main steps followed to build up and validate a migration estimation model that can be used, for a series of plastic food-contact materials and migrants, for regulatory purposes. Analytical solutions of the diffusion equation in conjunction with an 'upper limit' equation for the migrant diffusion coefficient, D(P), and the use of 'worst case' partitioning coefficients K(P,F) were used in the migration model. The results obtained were then validated, at a confidence level of 95%, by comparison with the available experimental evidence. The successful accomplishment of the goals of this project is reflected by the fact that in Directive 2002/72/EC, the European Commission included the mathematical modelling as an alternative tool to determine migration rates for compliance purposes.

Scoring best-worst data in unbalanced many-item designs, with applications to crowdsourcing semantic judgments.

PubMed

Hollis, Geoff

2018-04-01

Best-worst scaling is a judgment format in which participants are presented with a set of items and have to choose the superior and inferior items in the set. Best-worst scaling generates a large quantity of information per judgment because each judgment allows for inferences about the rank value of all unjudged items. This property of best-worst scaling makes it a promising judgment format for research in psychology and natural language processing concerned with estimating the semantic properties of tens of thousands of words. A variety of different scoring algorithms have been devised in the previous literature on best-worst scaling. However, due to problems of computational efficiency, these scoring algorithms cannot be applied efficiently to cases in which thousands of items need to be scored. New algorithms are presented here for converting responses from best-worst scaling into item scores for thousands of items (many-item scoring problems). These scoring algorithms are validated through simulation and empirical experiments, and considerations related to noise, the underlying distribution of true values, and trial design are identified that can affect the relative quality of the derived item scores. The newly introduced scoring algorithms consistently outperformed scoring algorithms used in the previous literature on scoring many-item best-worst data.

Coherent detection of frequency-hopped quadrature modulations in the presence of jamming. I - QPSK and QASK modulations

NASA Technical Reports Server (NTRS)

Simon, M. K.; Polydoros, A.

1981-01-01

This paper examines the performance of coherent QPSK and QASK systems combined with FH or FH/PN spread spectrum techniques in the presence of partial-band multitone or noise jamming. The worst-case jammer and worst-case performance are determined as functions of the signal-to-background noise ratio (SNR) and signal-to-jammer power ratio (SJR). Asymptotic results for high SNR are shown to have a linear dependence between the jammer's optimal power allocation and the system error probability performance.

Optimal Analyses for 3×n AB Games in the Worst Case

NASA Astrophysics Data System (ADS)

Huang, Li-Te; Lin, Shun-Shii

The past decades have witnessed a growing interest in research on deductive games such as Mastermind and AB game. Because of the complicated behavior of deductive games, tree-search approaches are often adopted to find their optimal strategies. In this paper, a generalized version of deductive games, called 3×n AB games, is introduced. However, traditional tree-search approaches are not appropriate for solving this problem since it can only solve instances with smaller n. For larger values of n, a systematic approach is necessary. Therefore, intensive analyses of playing 3×n AB games in the worst case optimally are conducted and a sophisticated method, called structural reduction, which aims at explaining the worst situation in this game is developed in the study. Furthermore, a worthwhile formula for calculating the optimal numbers of guesses required for arbitrary values of n is derived and proven to be final.

Estimated Probabililty of Chest Injury During an International Space Station Mission

NASA Technical Reports Server (NTRS)

Lewandowski, Beth E.; Milo, Eric A.; Brooker, John E.; Weaver, Aaron S.; Myers, Jerry G., Jr.

2013-01-01

The Integrated Medical Model (IMM) is a decision support tool that is useful to spaceflight mission planners and medical system designers when assessing risks and optimizing medical systems. The IMM project maintains a database of medical conditions that could occur during a spaceflight. The IMM project is in the process of assigning an incidence rate, the associated functional impairment, and a best and a worst case end state for each condition. The purpose of this work was to develop the IMM Chest Injury Module (CIM). The CIM calculates the incidence rate of chest injury per person-year of spaceflight on the International Space Station (ISS). The CIM was built so that the probability of chest injury during one year on ISS could be predicted. These results will be incorporated into the IMM Chest Injury Clinical Finding Form and used within the parent IMM model.

Estimated Probability of Traumatic Abdominal Injury During an International Space Station Mission

NASA Technical Reports Server (NTRS)

Lewandowski, Beth E.; Brooker, John E.; Weavr, Aaron S.; Myers, Jerry G., Jr.; McRae, Michael P.

2013-01-01

The Integrated Medical Model (IMM) is a decision support tool that is useful to spaceflight mission planners and medical system designers when assessing risks and optimizing medical systems. The IMM project maintains a database of medical conditions that could occur during a spaceflight. The IMM project is in the process of assigning an incidence rate, the associated functional impairment, and a best and a worst case end state for each condition. The purpose of this work was to develop the IMM Abdominal Injury Module (AIM). The AIM calculates an incidence rate of traumatic abdominal injury per person-year of spaceflight on the International Space Station (ISS). The AIM was built so that the probability of traumatic abdominal injury during one year on ISS could be predicted. This result will be incorporated into the IMM Abdominal Injury Clinical Finding Form and used within the parent IMM model.

How can health systems research reach the worst-off? A conceptual exploration.

PubMed

Pratt, Bridget; Hyder, Adnan A

2016-11-15

Health systems research is increasingly being conducted in low and middle-income countries (LMICs). Such research should aim to reduce health disparities between and within countries as a matter of global justice. For such research to do so, ethical guidance that is consistent with egalitarian theories of social justice proposes it ought to (amongst other things) focus on worst-off countries and research populations. Yet who constitutes the worst-off is not well-defined. By applying existing work on disadvantage from political philosophy, the paper demonstrates that (at least) two options exist for how to define the worst-off upon whom equity-oriented health systems research should focus: those who are worst-off in terms of health or those who are systematically disadvantaged. The paper describes in detail how both concepts can be understood and what metrics can be relied upon to identify worst-off countries and research populations at the sub-national level (groups, communities). To demonstrate how each can be used, the paper considers two real-world cases of health systems research and whether their choice of country (Uganda, India) and research population in 2011 would have been classified as amongst the worst-off according to the proposed concepts. The two proposed concepts can classify different countries and sub-national populations as worst-off. It is recommended that health researchers (or other actors) should use the concept that best reflects their moral commitments-namely, to perform research focused on reducing health inequalities or systematic disadvantage more broadly. If addressing the latter, it is recommended that they rely on the multidimensional poverty approach rather than the income approach to identify worst-off populations.

Phylogenetic diversity, functional trait diversity and extinction: avoiding tipping points and worst-case losses.

PubMed

Faith, Daniel P

2015-02-19

The phylogenetic diversity measure, ('PD'), measures the relative feature diversity of different subsets of taxa from a phylogeny. At the level of feature diversity, PD supports the broad goal of biodiversity conservation to maintain living variation and option values. PD calculations at the level of lineages and features include those integrating probabilities of extinction, providing estimates of expected PD. This approach has known advantages over the evolutionarily distinct and globally endangered (EDGE) methods. Expected PD methods also have limitations. An alternative notion of expected diversity, expected functional trait diversity, relies on an alternative non-phylogenetic model and allows inferences of diversity at the level of functional traits. Expected PD also faces challenges in helping to address phylogenetic tipping points and worst-case PD losses. Expected PD may not choose conservation options that best avoid worst-case losses of long branches from the tree of life. We can expand the range of useful calculations based on expected PD, including methods for identifying phylogenetic key biodiversity areas. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

Optimization of vibratory energy harvesters with stochastic parametric uncertainty: a new perspective

NASA Astrophysics Data System (ADS)

Haji Hosseinloo, Ashkan; Turitsyn, Konstantin

2016-04-01

Vibration energy harvesting has been shown as a promising power source for many small-scale applications mainly because of the considerable reduction in the energy consumption of the electronics and scalability issues of the conventional batteries. However, energy harvesters may not be as robust as the conventional batteries and their performance could drastically deteriorate in the presence of uncertainty in their parameters. Hence, study of uncertainty propagation and optimization under uncertainty is essential for proper and robust performance of harvesters in practice. While all studies have focused on expectation optimization, we propose a new and more practical optimization perspective; optimization for the worst-case (minimum) power. We formulate the problem in a generic fashion and as a simple example apply it to a linear piezoelectric energy harvester. We study the effect of parametric uncertainty in its natural frequency, load resistance, and electromechanical coupling coefficient on its worst-case power and then optimize for it under different confidence levels. The results show that there is a significant improvement in the worst-case power of thus designed harvester compared to that of a naively-optimized (deterministically-optimized) harvester.

Combining instruction prefetching with partial cache locking to improve WCET in real-time systems.

PubMed

Ni, Fan; Long, Xiang; Wan, Han; Gao, Xiaopeng

2013-01-01

Caches play an important role in embedded systems to bridge the performance gap between fast processor and slow memory. And prefetching mechanisms are proposed to further improve the cache performance. While in real-time systems, the application of caches complicates the Worst-Case Execution Time (WCET) analysis due to its unpredictable behavior. Modern embedded processors often equip locking mechanism to improve timing predictability of the instruction cache. However, locking the whole cache may degrade the cache performance and increase the WCET of the real-time application. In this paper, we proposed an instruction-prefetching combined partial cache locking mechanism, which combines an instruction prefetching mechanism (termed as BBIP) with partial cache locking to improve the WCET estimates of real-time applications. BBIP is an instruction prefetching mechanism we have already proposed to improve the worst-case cache performance and in turn the worst-case execution time. The estimations on typical real-time applications show that the partial cache locking mechanism shows remarkable WCET improvement over static analysis and full cache locking.

Combining Instruction Prefetching with Partial Cache Locking to Improve WCET in Real-Time Systems

PubMed Central

Ni, Fan; Long, Xiang; Wan, Han; Gao, Xiaopeng

2013-01-01

Caches play an important role in embedded systems to bridge the performance gap between fast processor and slow memory. And prefetching mechanisms are proposed to further improve the cache performance. While in real-time systems, the application of caches complicates the Worst-Case Execution Time (WCET) analysis due to its unpredictable behavior. Modern embedded processors often equip locking mechanism to improve timing predictability of the instruction cache. However, locking the whole cache may degrade the cache performance and increase the WCET of the real-time application. In this paper, we proposed an instruction-prefetching combined partial cache locking mechanism, which combines an instruction prefetching mechanism (termed as BBIP) with partial cache locking to improve the WCET estimates of real-time applications. BBIP is an instruction prefetching mechanism we have already proposed to improve the worst-case cache performance and in turn the worst-case execution time. The estimations on typical real-time applications show that the partial cache locking mechanism shows remarkable WCET improvement over static analysis and full cache locking. PMID:24386133

Dual respiratory and cardiac motion estimation in PET imaging: Methods design and quantitative evaluation.

PubMed

Feng, Tao; Wang, Jizhe; Tsui, Benjamin M W

2018-04-01

The goal of this study was to develop and evaluate four post-reconstruction respiratory and cardiac (R&C) motion vector field (MVF) estimation methods for cardiac 4D PET data. In Method 1, the dual R&C motions were estimated directly from the dual R&C gated images. In Method 2, respiratory motion (RM) and cardiac motion (CM) were separately estimated from the respiratory gated only and cardiac gated only images. The effects of RM on CM estimation were modeled in Method 3 by applying an image-based RM correction on the cardiac gated images before CM estimation, the effects of CM on RM estimation were neglected. Method 4 iteratively models the mutual effects of RM and CM during dual R&C motion estimations. Realistic simulation data were generated for quantitative evaluation of four methods. Almost noise-free PET projection data were generated from the 4D XCAT phantom with realistic R&C MVF using Monte Carlo simulation. Poisson noise was added to the scaled projection data to generate additional datasets of two more different noise levels. All the projection data were reconstructed using a 4D image reconstruction method to obtain dual R&C gated images. The four dual R&C MVF estimation methods were applied to the dual R&C gated images and the accuracy of motion estimation was quantitatively evaluated using the root mean square error (RMSE) of the estimated MVFs. Results show that among the four estimation methods, Methods 2 performed the worst for noise-free case while Method 1 performed the worst for noisy cases in terms of quantitative accuracy of the estimated MVF. Methods 4 and 3 showed comparable results and achieved RMSE lower by up to 35% than that in Method 1 for noisy cases. In conclusion, we have developed and evaluated 4 different post-reconstruction R&C MVF estimation methods for use in 4D PET imaging. Comparison of the performance of four methods on simulated data indicates separate R&C estimation with modeling of RM before CM estimation (Method 3) to be the best option for accurate estimation of dual R&C motion in clinical situation. © 2018 American Association of Physicists in Medicine.

The Future of Drought in the Southeastern U.S.: Projections from downscaled CMIP5 models

NASA Astrophysics Data System (ADS)

Keellings, D.; Engstrom, J.

2017-12-01

The Southeastern U.S. has been repeatedly impacted by severe droughts that have affected the environment and economy of the region. In this study the ability of 32 downscaled CMIP5 models, bias corrected using localized constructed analogs (LOCA), to simulate historical observations of dry spells from 1950-2005 are assessed using Perkins skill scores and significance tests. The models generally simulate the distribution of dry days well but there are significant differences between the ability of the best and worst performing models, particularly when it comes to the upper tail of the distribution. The best and worst performing models are then projected through 2099, using RCP 4.5 and 8.5, and estimates of 20 year return periods are compared. Only the higher skill models provide a good estimate of extreme dry spell lengths with simulations of 20 year return values within ± 5 days of observed values across the region. Projected return values differ by model grouping, but all models exhibit significant increases.

Severe anaemia associated with Plasmodium falciparum infection in children: consequences for additional blood sampling for research.

PubMed

Kuijpers, Laura Maria Francisca; Maltha, Jessica; Guiraud, Issa; Kaboré, Bérenger; Lompo, Palpouguini; Devlieger, Hugo; Van Geet, Chris; Tinto, Halidou; Jacobs, Jan

2016-06-02

Plasmodium falciparum infection may cause severe anaemia, particularly in children. When planning a diagnostic study on children suspected of severe malaria in sub-Saharan Africa, it was questioned how much blood could be safely sampled; intended blood volumes (blood cultures and EDTA blood) were 6 mL (children aged <6 years) and 10 mL (6-12 years). A previous review [Bull World Health Organ. 89: 46-53. 2011] recommended not to exceed 3.8 % of total blood volume (TBV). In a simulation exercise using data of children previously enrolled in a study about severe malaria and bacteraemia in Burkina Faso, the impact of this 3.8 % safety guideline was evaluated. For a total of 666 children aged >2 months to <12 years, data of age, weight and haemoglobin value (Hb) were available. For each child, the estimated TBV (TBVe) (mL) was calculated by multiplying the body weight (kg) by the factor 80 (ml/kg). Next, TBVe was corrected for the degree of anaemia to obtain the functional TBV (TBVf). The correction factor consisted of the rate 'Hb of the child divided by the reference Hb'; both the lowest ('best case') and highest ('worst case') reference Hb values were used. Next, the exact volume that a 3.8 % proportion of this TBVf would present was calculated and this volume was compared to the blood volumes that were intended to be sampled. When applied to the Burkina Faso cohort, the simulation exercise pointed out that in 5.3 % (best case) and 11.4 % (worst case) of children the blood volume intended to be sampled would exceed the volume as defined by the 3.8 % safety guideline. Highest proportions would be in the age groups 2-6 months (19.0 %; worst scenario) and 6 months-2 years (15.7 %; worst case scenario). A positive rapid diagnostic test for P. falciparum was associated with an increased risk of violating the safety guideline in the worst case scenario (p = 0.016). Blood sampling in children for research in P. falciparum endemic settings may easily violate the proposed safety guideline when applied to TBVf. Ethical committees and researchers should be wary of this and take appropriate precautions.

The influence of climate change on Tanzania's hydropower sustainability

NASA Astrophysics Data System (ADS)

Sperna Weiland, Frederiek; Boehlert, Brent; Meijer, Karen; Schellekens, Jaap; Magnell, Jan-Petter; Helbrink, Jakob; Kassana, Leonard; Liden, Rikard

2015-04-01

Economic costs induced by current climate variability are large for Tanzania and may further increase due to future climate change. The Tanzanian National Climate Change Strategy addressed the need for stabilization of hydropower generation and strengthening of water resources management. Increased hydropower generation can contribute to sustainable use of energy resources and stabilization of the national electricity grid. To support Tanzania the World Bank financed this study in which the impact of climate change on the water resources and related hydropower generation capacity of Tanzania is assessed. To this end an ensemble of 78 GCM projections from both the CMIP3 and CMIP5 datasets was bias-corrected and down-scaled to 0.5 degrees resolution following the BCSD technique using the Princeton Global Meteorological Forcing Dataset as a reference. To quantify the hydrological impacts of climate change by 2035 the global hydrological model PCR-GLOBWB was set-up for Tanzania at a resolution of 3 minutes and run with all 78 GCM datasets. From the full set of projections a probable (median) and worst case scenario (95th percentile) were selected based upon (1) the country average Climate Moisture Index and (2) discharge statistics of relevance to hydropower generation. Although precipitation from the Princeton dataset shows deviations from local station measurements and the global hydrological model does not perfectly reproduce local scale hydrographs, the main discharge characteristics and precipitation patterns are represented well. The modeled natural river flows were adjusted for water demand and irrigation within the water resources model RIBASIM (both historical values and future scenarios). Potential hydropower capacity was assessed with the power market simulation model PoMo-C that considers both reservoir inflows obtained from RIBASIM and overall electricity generation costs. Results of the study show that climate change is unlikely to negatively affect the average potential of future hydropower production; it will likely make hydropower more profitable. Yet, the uncertainty in climate change projections remains large and risks are significant, adaptation strategies should ideally consider a worst case scenario to ensure robust power generation. Overall a diversified power generation portfolio, anchored in hydropower and supported by other renewables and fossil fuel-based energy sources, is the best solution for Tanzania

Discussions On Worst-Case Test Condition For Single Event Burnout

NASA Astrophysics Data System (ADS)

Liu, Sandra; Zafrani, Max; Sherman, Phillip

2011-10-01

This paper discusses the failure characteristics of single- event burnout (SEB) on power MOSFETs based on analyzing the quasi-stationary avalanche simulation curves. The analyses show the worst-case test condition for SEB would be using the ion that has the highest mass that would result in the highest transient current due to charge deposition and displacement damage. The analyses also show it is possible to build power MOSFETs that will not exhibit SEB even when tested with the heaviest ion, which have been verified by heavy ion test data on SEB sensitive and SEB immune devices.

Atmospheric transport of radioactive debris to Norway in case of a hypothetical accident related to the recovery of the Russian submarine K-27.

PubMed

Bartnicki, Jerzy; Amundsen, Ingar; Brown, Justin; Hosseini, Ali; Hov, Øystein; Haakenstad, Hilde; Klein, Heiko; Lind, Ole Christian; Salbu, Brit; Szacinski Wendel, Cato C; Ytre-Eide, Martin Album

2016-01-01

The Russian nuclear submarine K-27 suffered a loss of coolant accident in 1968 and with nuclear fuel in both reactors it was scuttled in 1981 in the outer part of Stepovogo Bay located on the eastern coast of Novaya Zemlya. The inventory of spent nuclear fuel on board the submarine is of concern because it represents a potential source of radioactive contamination of the Kara Sea and a criticality accident with potential for long-range atmospheric transport of radioactive particles cannot be ruled out. To address these concerns and to provide a better basis for evaluating possible radiological impacts of potential releases in case a salvage operation is initiated, we assessed the atmospheric transport of radionuclides and deposition in Norway from a hypothetical criticality accident on board the K-27. To achieve this, a long term (33 years) meteorological database has been prepared and used for selection of the worst case meteorological scenarios for each of three selected locations of the potential accident. Next, the dispersion model SNAP was run with the source term for the worst-case accident scenario and selected meteorological scenarios. The results showed predictions to be very sensitive to the estimation of the source term for the worst-case accident and especially to the sizes and densities of released radioactive particles. The results indicated that a large area of Norway could be affected, but that the deposition in Northern Norway would be considerably higher than in other areas of the country. The simulations showed that deposition from the worst-case scenario of a hypothetical K-27 accident would be at least two orders of magnitude lower than the deposition observed in Norway following the Chernobyl accident. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Acoustic and Thermal Testing of an Integrated Multilayer Insulation and Broad Area Cooling Shield System

NASA Technical Reports Server (NTRS)

Wood, Jessica J.; Foster, Lee W.

2013-01-01

A Multilayer Insulation (MLI) and Broad Area Cooling (BAC) shield thermal control system shows promise for long-duration storage of cryogenic propellant. The NASA Cryogenic Propellant Storage and Transfer (CPST) project is investigating the thermal and structural performance of this tank-applied integrated system. The MLI/BAC Shield Acoustic and Thermal Test was performed to evaluate the MLI/BAC shield's structural performance by subjecting it to worst-case launch acoustic loads. Identical thermal tests using Liquid Nitrogen (LN2) were performed before and after the acoustic test. The data from these tests was compared to determine if any degradation occurred in the thermal performance of the system as a result of exposure to the acoustic loads. The thermal test series consisted of two primary components: a passive boil-off test to evaluate the MLI performance and an active cooling test to evaluate the integrated MLI/BAC shield system with chilled vapor circulating through the BAC shield tubes. The acoustic test used loads closely matching the worst-case envelope of all launch vehicles currently under consideration for CPST. Acoustic test results yielded reasonable responses for the given load. The thermal test matrix was completed prior to the acoustic test and successfully repeated after the acoustic test. Data was compared and yielded near identical results, indicating that the MLI/BAC shield configuration tested in this series is an option for structurally implementing this thermal control system concept.

Finite volume analysis of temperature effects induced by active MRI implants: 2. Defects on active MRI implants causing hot spots.

PubMed

Busch, Martin H J; Vollmann, Wolfgang; Grönemeyer, Dietrich H W

2006-05-26

Active magnetic resonance imaging implants, for example stents, stent grafts or vena cava filters, are constructed as wireless inductively coupled transmit and receive coils. They are built as a resonator tuned to the Larmor frequency of a magnetic resonance system. The resonator can be added to or incorporated within the implant. This technology can counteract the shielding caused by eddy currents inside the metallic implant structure. This may allow getting diagnostic information of the implant lumen (in stent stenosis or thrombosis for example). The electro magnetic rf-pulses during magnetic resonance imaging induce a current in the circuit path of the resonator. A by material fatigue provoked partial rupture of the circuit path or a broken wire with touching surfaces can set up a relatively high resistance on a very short distance, which may behave as a point-like power source, a hot spot, inside the body part the resonator is implanted to. This local power loss inside a small volume can reach (1/4) of the total power loss of the intact resonating circuit, which itself is proportional to the product of the resonator volume and the quality factor and depends as well from the orientation of the resonator with respect to the main magnetic field and the imaging sequence the resonator is exposed to. First an analytical solution of a hot spot for thermal equilibrium is described. This analytical solution with a definite hot spot power loss represents the worst case scenario for thermal equilibrium inside a homogeneous medium without cooling effects. Starting with this worst case assumptions additional conditions are considered in a numerical simulation, which are more realistic and may make the results less critical. The analytical solution as well as the numerical simulations use the experimental experience of the maximum hot spot power loss of implanted resonators with a definite volume during magnetic resonance imaging investigations. The finite volume analysis calculates the time developing temperature maps for the model of a broken linear metallic wire embedded in tissue. Half of the total hot spot power loss is assumed to diffuse into both wire parts at the location of a defect. The energy is distributed from there by heat conduction. Additionally the effect of blood perfusion and blood flow is respected in some simulations because the simultaneous appearance of all worst case conditions, especially the absence of blood perfusion and blood flow near the hot spot, is very unlikely for vessel implants. The analytical solution as worst case scenario as well as the finite volume analysis for near worst case situations show not negligible volumes with critical temperature increases for part of the modeled hot spot situations. MR investigations with a high rf-pulse density lasting below a minute can establish volumes of several cubic millimeters with temperature increases high enough to start cell destruction. Longer exposure times can involve volumes larger than 100 mm3. Even temperature increases in the range of thermal ablation are reached for substantial volumes. MR sequence exposure time and hot spot power loss are the primary factors influencing the volume with critical temperature increases. Wire radius, wire material as well as the physiological parameters blood perfusion and blood flow inside larger vessels reduce the volume with critical temperature increases, but do not exclude a volume with critical tissue heating for resonators with a large product of resonator volume and quality factor. The worst case scenario assumes thermal equilibrium for a hot spot embedded in homogeneous tissue without any cooling due to blood perfusion or flow. The finite volume analysis can calculate the results for near and not close to worst case conditions. For both cases a substantial volume can reach a critical temperature increase in a short time. The analytical solution, as absolute worst case, points out that resonators with a small product of inductance volume and quality factor (Q V(ind) < 2 cm3) are definitely save. Stents for coronary vessels or resonators used as tracking devices for interventional procedures therefore have no risk of high temperature increases. The finite volume analysis shows for sure that also conditions not close to the worst case reach physiologically critical temperature increases for implants with a large product of inductance volume and quality factor (Q V(ind) > 10 cm3). Such resonators exclude patients from exactly the MRI investigation these devices are made for.

Finite volume analysis of temperature effects induced by active MRI implants: 2. Defects on active MRI implants causing hot spots

PubMed Central

Busch, Martin HJ; Vollmann, Wolfgang; Grönemeyer, Dietrich HW

2006-01-01

Background Active magnetic resonance imaging implants, for example stents, stent grafts or vena cava filters, are constructed as wireless inductively coupled transmit and receive coils. They are built as a resonator tuned to the Larmor frequency of a magnetic resonance system. The resonator can be added to or incorporated within the implant. This technology can counteract the shielding caused by eddy currents inside the metallic implant structure. This may allow getting diagnostic information of the implant lumen (in stent stenosis or thrombosis for example). The electro magnetic rf-pulses during magnetic resonance imaging induce a current in the circuit path of the resonator. A by material fatigue provoked partial rupture of the circuit path or a broken wire with touching surfaces can set up a relatively high resistance on a very short distance, which may behave as a point-like power source, a hot spot, inside the body part the resonator is implanted to. This local power loss inside a small volume can reach ¼ of the total power loss of the intact resonating circuit, which itself is proportional to the product of the resonator volume and the quality factor and depends as well from the orientation of the resonator with respect to the main magnetic field and the imaging sequence the resonator is exposed to. Methods First an analytical solution of a hot spot for thermal equilibrium is described. This analytical solution with a definite hot spot power loss represents the worst case scenario for thermal equilibrium inside a homogeneous medium without cooling effects. Starting with this worst case assumptions additional conditions are considered in a numerical simulation, which are more realistic and may make the results less critical. The analytical solution as well as the numerical simulations use the experimental experience of the maximum hot spot power loss of implanted resonators with a definite volume during magnetic resonance imaging investigations. The finite volume analysis calculates the time developing temperature maps for the model of a broken linear metallic wire embedded in tissue. Half of the total hot spot power loss is assumed to diffuse into both wire parts at the location of a defect. The energy is distributed from there by heat conduction. Additionally the effect of blood perfusion and blood flow is respected in some simulations because the simultaneous appearance of all worst case conditions, especially the absence of blood perfusion and blood flow near the hot spot, is very unlikely for vessel implants. Results The analytical solution as worst case scenario as well as the finite volume analysis for near worst case situations show not negligible volumes with critical temperature increases for part of the modeled hot spot situations. MR investigations with a high rf-pulse density lasting below a minute can establish volumes of several cubic millimeters with temperature increases high enough to start cell destruction. Longer exposure times can involve volumes larger than 100 mm3. Even temperature increases in the range of thermal ablation are reached for substantial volumes. MR sequence exposure time and hot spot power loss are the primary factors influencing the volume with critical temperature increases. Wire radius, wire material as well as the physiological parameters blood perfusion and blood flow inside larger vessels reduce the volume with critical temperature increases, but do not exclude a volume with critical tissue heating for resonators with a large product of resonator volume and quality factor. Conclusion The worst case scenario assumes thermal equilibrium for a hot spot embedded in homogeneous tissue without any cooling due to blood perfusion or flow. The finite volume analysis can calculate the results for near and not close to worst case conditions. For both cases a substantial volume can reach a critical temperature increase in a short time. The analytical solution, as absolute worst case, points out that resonators with a small product of inductance volume and quality factor (Q Vind < 2 cm3) are definitely save. Stents for coronary vessels or resonators used as tracking devices for interventional procedures therefore have no risk of high temperature increases. The finite volume analysis shows for sure that also conditions not close to the worst case reach physiologically critical temperature increases for implants with a large product of inductance volume and quality factor (Q Vind > 10 cm3). Such resonators exclude patients from exactly the MRI investigation these devices are made for. PMID:16729878

Geometrical Design of a Scalable Overlapping Planar Spiral Coil Array to Generate a Homogeneous Magnetic Field.

PubMed

Jow, Uei-Ming; Ghovanloo, Maysam

2012-12-21

We present a design methodology for an overlapping hexagonal planar spiral coil (hex-PSC) array, optimized for creation of a homogenous magnetic field for wireless power transmission to randomly moving objects. The modular hex-PSC array has been implemented in the form of three parallel conductive layers, for which an iterative optimization procedure defines the PSC geometries. Since the overlapping hex-PSCs in different layers have different characteristics, the worst case coil-coupling condition should be designed to provide the maximum power transfer efficiency (PTE) in order to minimize the spatial received power fluctuations. In the worst case, the transmitter (Tx) hex-PSC is overlapped by six PSCs and surrounded by six other adjacent PSCs. Using a receiver (Rx) coil, 20 mm in radius, at the coupling distance of 78 mm and maximum lateral misalignment of 49.1 mm (1/√3 of the PSC radius) we can receive power at a PTE of 19.6% from the worst case PSC. Furthermore, we have studied the effects of Rx coil tilting and concluded that the PTE degrades significantly when θ > 60°. Solutions are: 1) activating two adjacent overlapping hex-PSCs simultaneously with out-of-phase excitations to create horizontal magnetic flux and 2) inclusion of a small energy storage element in the Rx module to maintain power in the worst case scenarios. In order to verify the proposed design methodology, we have developed the EnerCage system, which aims to power up biological instruments attached to or implanted in freely behaving small animal subjects' bodies in long-term electrophysiology experiments within large experimental arenas.

Failed State 2030: Nigeria - A Case Study

DTIC Science & Technology

2011-02-01

disastrous ecological conditions in its Niger Delta region, and is fighting one of the modern world?s worst legacies of political and economic corruption. A ...world’s worst legacies of political and economic corruption. A nation with more than 350 ethnic groups, 250 languages, and three distinct religious...happening in the world. The discus- sion herein is a mix of cultural sociology, political science, econom - ics, military science (sometimes called

Decision making with epistemic uncertainty under safety constraints: An application to seismic design

USGS Publications Warehouse

Veneziano, D.; Agarwal, A.; Karaca, E.

2009-01-01

The problem of accounting for epistemic uncertainty in risk management decisions is conceptually straightforward, but is riddled with practical difficulties. Simple approximations are often used whereby future variations in epistemic uncertainty are ignored or worst-case scenarios are postulated. These strategies tend to produce sub-optimal decisions. We develop a general framework based on Bayesian decision theory and exemplify it for the case of seismic design of buildings. When temporal fluctuations of the epistemic uncertainties and regulatory safety constraints are included, the optimal level of seismic protection exceeds the normative level at the time of construction. Optimal Bayesian decisions do not depend on the aleatory or epistemic nature of the uncertainties, but only on the total (epistemic plus aleatory) uncertainty and how that total uncertainty varies randomly during the lifetime of the project. ?? 2009 Elsevier Ltd. All rights reserved.

Acquisition Management for System-of-Systems: Requirement Evolution and Acquisition Strategy Planning

DTIC Science & Technology

2012-04-30

DoD SERC Aeronautics & Astronautics 5/16/2012 NPS 9th Annual Acquisition Research Symposium...0.6 0.7 0.8 0.9 1 0 60 120 180 240 300 360 420 480 540 600 Pr ob ab ili ty to c om pl et e a m is si on Time (mins) architecture 1 architecture 2...1 6 11 /1 6 12 /1 6 13 /1 6 14 /1 6 15 /1 6 1Pr ob ab ili ty to c om pl et e a m is si on % of system failures worst-case in arch1 worst-case in

Fine-Scale Structure Design for 3D Printing

NASA Astrophysics Data System (ADS)

Panetta, Francis Julian

Modern additive fabrication technologies can manufacture shapes whose geometric complexities far exceed what existing computational design tools can analyze or optimize. At the same time, falling costs have placed these fabrication technologies within the average consumer's reach. Especially for inexpert designers, new software tools are needed to take full advantage of 3D printing technology. This thesis develops such tools and demonstrates the exciting possibilities enabled by fine-tuning objects at the small scales achievable by 3D printing. The thesis applies two high-level ideas to invent these tools: two-scale design and worst-case analysis. The two-scale design approach addresses the problem that accurately simulating--let alone optimizing--the full-resolution geometry sent to the printer requires orders of magnitude more computational power than currently available. However, we can decompose the design problem into a small-scale problem (designing tileable structures achieving a particular deformation behavior) and a macro-scale problem (deciding where to place these structures in the larger object). This separation is particularly effective, since structures for every useful behavior can be designed once, stored in a database, then reused for many different macroscale problems. Worst-case analysis refers to determining how likely an object is to fracture by studying the worst possible scenario: the forces most efficiently breaking it. This analysis is needed when the designer has insufficient knowledge or experience to predict what forces an object will undergo, or when the design is intended for use in many different scenarios unknown a priori. The thesis begins by summarizing the physics and mathematics necessary to rigorously approach these design and analysis problems. Specifically, the second chapter introduces linear elasticity and periodic homogenization. The third chapter presents a pipeline to design microstructures achieving a wide range of effective isotropic elastic material properties on a single-material 3D printer. It also proposes a macroscale optimization algorithm placing these microstructures to achieve deformation goals under prescribed loads. The thesis then turns to worst-case analysis, first considering the macroscale problem: given a user's design, the fourth chapter aims to determine the distribution of pressures over the surface creating the highest stress at any point in the shape. Solving this problem exactly is difficult, so we introduce two heuristics: one to focus our efforts on only regions likely to concentrate stresses and another converting the pressure optimization into an efficient linear program. Finally, the fifth chapter introduces worst-case analysis at the microscopic scale, leveraging the insight that the structure of periodic homogenization enables us to solve the problem exactly and efficiently. Then we use this worst-case analysis to guide a shape optimization, designing structures with prescribed deformation behavior that experience minimal stresses in generic use.

SU-F-R-39: Effects of Radiation Dose Reduction On Renal Cell Carcinoma Discrimination Using Multi-Phasic CT Imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wahi-Anwar, M; Young, S; Lo, P

Purpose: A method to discriminate different types of renal cell carcinoma (RCC) was developed using attenuation values observed in multiphasic contrast-enhanced CT. This work evaluates the sensitivity of this RCC discrimination task at different CT radiation dose levels. Methods: We selected 5 cases of kidney lesion patients who had undergone four-phase CT scans covering the abdomen to the lilac crest. Through an IRB-approved study, the scans were conducted on 64-slice CT scanners (Definition AS/Definition Flash, Siemens Healthcare) using automatic tube-current modulation (TCM). The protocol included an initial baseline unenhanced scan, followed by three post-contrast injection phases. CTDIvol (32 cm phantom)more » measured between 9 to 35 mGy for any given phase. As a preliminary study, we limited the scope to the cortico-medullary phase—shown previously to be the most discriminative phase. A previously validated method was used to simulate a reduced dose acquisition via adding noise to raw CT sinogram data, emulating corresponding images at simulated doses of 50%, 25%, and 10%. To discriminate the lesion subtype, ROIs were placed in the most enhancing region of the lesion. The mean HU value of an ROI was extracted and used to discriminate to the worst-case RCC subtype, ranked in the order of clear cell, papillary, chromophobe and the benign oncocytoma. Results: Two patients exhibited a change of worst case RCC subtype between original and simulated scans, at 25% and 10% doses. In one case, the worst-case RCC subtype changed from oncocytoma to chromophobe at 10% and 25% doses, while the other case changed from oncocytoma to clear cell at 10% dose. Conclusion: Based on preliminary results from an initial cohort of 5 patients, worst-case RCC subtypes remained constant at all simulated dose levels except for 2 patients. Further study conducted on more patients will be needed to confirm our findings. Institutional research agreement, Siemens Healthcare; Past recipient, research grant support, Siemens Healthcare; Consultant, Toshiba America Medical Systems; Consultant, Samsung Electronics; NIH Grant Support from: U01 CA181156.« less

Comparison of linear and nonlinear programming approaches for "worst case dose" and "minmax" robust optimization of intensity-modulated proton therapy dose distributions.

PubMed

Zaghian, Maryam; Cao, Wenhua; Liu, Wei; Kardar, Laleh; Randeniya, Sharmalee; Mohan, Radhe; Lim, Gino

2017-03-01

Robust optimization of intensity-modulated proton therapy (IMPT) takes uncertainties into account during spot weight optimization and leads to dose distributions that are resilient to uncertainties. Previous studies demonstrated benefits of linear programming (LP) for IMPT in terms of delivery efficiency by considerably reducing the number of spots required for the same quality of plans. However, a reduction in the number of spots may lead to loss of robustness. The purpose of this study was to evaluate and compare the performance in terms of plan quality and robustness of two robust optimization approaches using LP and nonlinear programming (NLP) models. The so-called "worst case dose" and "minmax" robust optimization approaches and conventional planning target volume (PTV)-based optimization approach were applied to designing IMPT plans for five patients: two with prostate cancer, one with skull-based cancer, and two with head and neck cancer. For each approach, both LP and NLP models were used. Thus, for each case, six sets of IMPT plans were generated and assessed: LP-PTV-based, NLP-PTV-based, LP-worst case dose, NLP-worst case dose, LP-minmax, and NLP-minmax. The four robust optimization methods behaved differently from patient to patient, and no method emerged as superior to the others in terms of nominal plan quality and robustness against uncertainties. The plans generated using LP-based robust optimization were more robust regarding patient setup and range uncertainties than were those generated using NLP-based robust optimization for the prostate cancer patients. However, the robustness of plans generated using NLP-based methods was superior for the skull-based and head and neck cancer patients. Overall, LP-based methods were suitable for the less challenging cancer cases in which all uncertainty scenarios were able to satisfy tight dose constraints, while NLP performed better in more difficult cases in which most uncertainty scenarios were hard to meet tight dose limits. For robust optimization, the worst case dose approach was less sensitive to uncertainties than was the minmax approach for the prostate and skull-based cancer patients, whereas the minmax approach was superior for the head and neck cancer patients. The robustness of the IMPT plans was remarkably better after robust optimization than after PTV-based optimization, and the NLP-PTV-based optimization outperformed the LP-PTV-based optimization regarding robustness of clinical target volume coverage. In addition, plans generated using LP-based methods had notably fewer scanning spots than did those generated using NLP-based methods. © 2017 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

Cost-efficacy of biologic therapies for psoriatic arthritis from the perspective of the Taiwanese healthcare system.

PubMed

Yang, Tsong-Shing; Chi, Ching-Chi; Wang, Shu-Hui; Lin, Jing-Chi; Lin, Ko-Ming

2016-10-01

Biologic therapies are more effective but more costly than conventional therapies in treating psoriatic arthritis. To evaluate the cost-efficacy of etanercept, adalimumab and golimumab therapies in treating active psoriatic arthritis in a Taiwanese setting. We conducted a meta-analysis of randomized placebo-controlled trials to calculate the incremental efficacy of etanercept, adalimumab and golimumab, respectively, in achieving Psoriatic Arthritis Response Criteria (PsARC) and a 20% improvement in the American College of Rheumatology score (ACR20). The base, best, and worst case incremental cost-effectiveness ratios (ICERs) for one subject to achieve PsARC and ACR20 were calculated. The annual ICER per PsARC responder were US$27 047 (best scenario US$16 619; worst scenario US$31 350), US$39 339 (best scenario US$31 846; worst scenario US$53 501) and US$27 085 (best scenario US$22 716; worst scenario US$33 534) for etanercept, adalimumab and golimumab, respectively. The annual ICER per ACR20 responder were US$27 588 (best scenario US$20 900; worst scenario US$41 800), US$39 339 (best scenario US$25 236; worst scenario US$83 595) and US$33 534 (best scenario US$27 616; worst scenario US$44 013) for etanercept, adalimumab and golimumab, respectively. In a Taiwanese setting, etanercept had the lowest annual costs per PsARC and ACR20 responder, while adalimumab had the highest annual costs per PsARC and ACR responder. © 2015 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

A Worst-Case Approach for On-Line Flutter Prediction

NASA Technical Reports Server (NTRS)

Lind, Rick C.; Brenner, Martin J.

1998-01-01

Worst-case flutter margins may be computed for a linear model with respect to a set of uncertainty operators using the structured singular value. This paper considers an on-line implementation to compute these robust margins in a flight test program. Uncertainty descriptions are updated at test points to account for unmodeled time-varying dynamics of the airplane by ensuring the robust model is not invalidated by measured flight data. Robust margins computed with respect to this uncertainty remain conservative to the changing dynamics throughout the flight. A simulation clearly demonstrates this method can improve the efficiency of flight testing by accurately predicting the flutter margin to improve safety while reducing the necessary flight time.

Minimax Quantum Tomography: Estimators and Relative Entropy Bounds.

PubMed

Ferrie, Christopher; Blume-Kohout, Robin

2016-03-04

A minimax estimator has the minimum possible error ("risk") in the worst case. We construct the first minimax estimators for quantum state tomography with relative entropy risk. The minimax risk of nonadaptive tomography scales as O(1/sqrt[N])-in contrast to that of classical probability estimation, which is O(1/N)-where N is the number of copies of the quantum state used. We trace this deficiency to sampling mismatch: future observations that determine risk may come from a different sample space than the past data that determine the estimate. This makes minimax estimators very biased, and we propose a computationally tractable alternative with similar behavior in the worst case, but superior accuracy on most states.

Level II scour analysis for Bridge 120 (LEICUS00070120) on U.S. Route 7, crossing the Leicester River, Leicester, Vermont

USGS Publications Warehouse

Boehmler, Erick M.; Severance, Timothy

1997-01-01

Contraction scour for all modelled flows ranged from 3.8 to 6.1 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 4.0 to 6.7 ft. The worst-case abutment scour also occurred at the 500-year discharge. Pier scour ranged from 9.1 to 10.2. The worst-case pier scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 49 (WODSTH00990049) on Town Highway 99, crossing Gulf Brook, Woodstock, Vermont

USGS Publications Warehouse

Olson, Scott A.; Hammond, Robert E.

1996-01-01

Contraction scour for all modelled flows ranged from 0.0 to 0.9 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour at the left abutment ranged from 3.1 to 10.3 ft. with the worst-case occurring at the 500-year discharge. Abutment scour at the right abutment ranged from 6.4 to 10.4 ft. with the worst-case occurring at the 100-year discharge.Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 26 (JAMATH00010026) on Town Highway 1, crossing Ball Mountain Brook, Jamaica, Vermont

USGS Publications Warehouse

Burns, Ronda L.; Medalie, Laura

1997-01-01

Contraction scour for the modelled flows ranged from 1.0 to 2.7 ft. The worst-case contraction scour occurred at the incipient-overtopping discharge. Abutment scour ranged from 8.4 to 17.6 ft. The worst-case abutment scour for the right abutment occurred at the incipient-overtopping discharge. For the left abutment, the worst-case abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 37 (TOWNTH00290037) on Town Highway 29, crossing Mill Brook, Townshend, Vermont

USGS Publications Warehouse

Burns, R.L.; Medalie, Laura

1998-01-01

Contraction scour for all modelled flows ranged from 0.0 to 2.1 ft. The worst-case contraction scour occurred at the 500-year discharge. Left abutment scour ranged from 6.7 to 8.7 ft. The worst-case left abutment scour occurred at the incipient roadway-overtopping discharge. Right abutment scour ranged from 7.8 to 9.5 ft. The worst-case right abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A crosssection of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and Davis, 1995, p. 46). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

A semi-quantitative World Health Organization grading scheme evaluating worst tumor differentiation predicts disease-free survival in oral squamous carcinoma patients.

PubMed

Jain, Dhruv; Tikku, Gargi; Bhadana, Pallavi; Dravid, Chandrashekhar; Grover, Rajesh Kumar

2017-08-01

We investigated World Health Organization (WHO) grading and pattern of invasion based histological schemes as independent predictors of disease-free survival, in oral squamous carcinoma patients. Tumor resection slides of eighty-seven oral squamous carcinoma patients [pTNM: I&II/III&IV-32/55] were evaluated. Besides examining various patterns of invasion, invasive front grade, predominant and worst (highest) WHO grade were recorded. For worst WHO grading, poor-undifferentiated component was estimated semi-quantitatively at advancing tumor edge (invasive growth front) in histology sections. Tumor recurrence was observed in 31 (35.6%) cases. The 2-year disease-free survival was 47% [Median: 656; follow-up: 14-1450] days. Using receiver operating characteristic curves, we defined poor-undifferentiated component exceeding 5% of tumor as the cutoff to assign an oral squamous carcinoma as grade-3, when following worst WHO grading. Kaplan-Meier curves for disease-free survival revealed prognostic association with nodal involvement, tumor size, worst WHO grading; most common pattern of invasion and invasive pattern grading score (sum of two most predominant patterns of invasion). In further multivariate analysis, tumor size (>2.5cm) and worst WHO grading (grade-3 tumors) independently predicted reduced disease-free survival [HR, 2.85; P=0.028 and HR, 3.37; P=0.031 respectively]. The inter-observer agreement was moderate for observers who semi-quantitatively estimated percentage of poor-undifferentiated morphology in oral squamous carcinomas. Our results support the value of semi-quantitative method to assign tumors as grade-3 with worst WHO grading for predicting reduced disease-free survival. Despite limitations, of the various histological tumor stratification schemes, WHO grading holds adjunctive value for its prognostic role, ease and universal familiarity. Copyright © 2017 Elsevier Inc. All rights reserved.

Isolator fragmentation and explosive initiation tests

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dickson, Peter; Rae, Philip John; Foley, Timothy J.

2016-09-19

Three tests were conducted to evaluate the effects of firing an isolator in proximity to a barrier or explosive charge. The tests with explosive were conducted without a barrier, on the basis that since any barrier will reduce the shock transmitted to the explosive, bare explosive represents the worst-case from an inadvertent initiation perspective. No reaction was observed. The shock caused by the impact of a representative plastic material on both bare and cased PBX 9501 is calculated in the worst-case, 1-D limit, and the known shock response of the HE is used to estimate minimum run-to-detonation lengths. The estimatesmore » demonstrate that even 1-D impacts would not be of concern and that, accordingly, the divergent shocks due to isolator fragment impact are of no concern as initiating stimuli.« less

Isolator fragmentation and explosive initiation tests

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dickson, Peter; Rae, Philip John; Foley, Timothy J.

2015-09-30

Three tests were conducted to evaluate the effects of firing an isolator in proximity to a barrier or explosive charge. The tests with explosive were conducted without barrier, on the basis that since any barrier will reduce the shock transmitted to the explosive, bare explosive represents the worst-case from an inadvertent initiation perspective. No reaction was observed. The shock caused by the impact of a representative plastic material on both bare and cased PBX9501 is calculated in the worst-case, 1-D limit, and the known shock response of the HE is used to estimate minimum run-to-detonation lengths. The estimates demonstrate thatmore » even 1-D impacts would not be of concern and that, accordingly, the divergent shocks due to isolator fragment impact are of no concern as initiating stimuli.« less

Conscious worst case definition for risk assessment, part I: a knowledge mapping approach for defining most critical risk factors in integrative risk management of chemicals and nanomaterials.

PubMed

Sørensen, Peter B; Thomsen, Marianne; Assmuth, Timo; Grieger, Khara D; Baun, Anders

2010-08-15

This paper helps bridge the gap between scientists and other stakeholders in the areas of human and environmental risk management of chemicals and engineered nanomaterials. This connection is needed due to the evolution of stakeholder awareness and scientific progress related to human and environmental health which involves complex methodological demands on risk management. At the same time, the available scientific knowledge is also becoming more scattered across multiple scientific disciplines. Hence, the understanding of potentially risky situations is increasingly multifaceted, which again challenges risk assessors in terms of giving the 'right' relative priority to the multitude of contributing risk factors. A critical issue is therefore to develop procedures that can identify and evaluate worst case risk conditions which may be input to risk level predictions. Therefore, this paper suggests a conceptual modelling procedure that is able to define appropriate worst case conditions in complex risk management. The result of the analysis is an assembly of system models, denoted the Worst Case Definition (WCD) model, to set up and evaluate the conditions of multi-dimensional risk identification and risk quantification. The model can help optimize risk assessment planning by initial screening level analyses and guiding quantitative assessment in relation to knowledge needs for better decision support concerning environmental and human health protection or risk reduction. The WCD model facilitates the evaluation of fundamental uncertainty using knowledge mapping principles and techniques in a way that can improve a complete uncertainty analysis. Ultimately, the WCD is applicable for describing risk contributing factors in relation to many different types of risk management problems since it transparently and effectively handles assumptions and definitions and allows the integration of different forms of knowledge, thereby supporting the inclusion of multifaceted risk components in cumulative risk management. Copyright 2009 Elsevier B.V. All rights reserved.

Faster than classical quantum algorithm for dense formulas of exact satisfiability and occupation problems

NASA Astrophysics Data System (ADS)

Mandrà, Salvatore; Giacomo Guerreschi, Gian; Aspuru-Guzik, Alán

2016-07-01

We present an exact quantum algorithm for solving the Exact Satisfiability problem, which belongs to the important NP-complete complexity class. The algorithm is based on an intuitive approach that can be divided into two parts: the first step consists in the identification and efficient characterization of a restricted subspace that contains all the valid assignments of the Exact Satisfiability; while the second part performs a quantum search in such restricted subspace. The quantum algorithm can be used either to find a valid assignment (or to certify that no solution exists) or to count the total number of valid assignments. The query complexities for the worst-case are respectively bounded by O(\\sqrt{{2}n-{M\\prime }}) and O({2}n-{M\\prime }), where n is the number of variables and {M}\\prime the number of linearly independent clauses. Remarkably, the proposed quantum algorithm results to be faster than any known exact classical algorithm to solve dense formulas of Exact Satisfiability. As a concrete application, we provide the worst-case complexity for the Hamiltonian cycle problem obtained after mapping it to a suitable Occupation problem. Specifically, we show that the time complexity for the proposed quantum algorithm is bounded by O({2}n/4) for 3-regular undirected graphs, where n is the number of nodes. The same worst-case complexity holds for (3,3)-regular bipartite graphs. As a reference, the current best classical algorithm has a (worst-case) running time bounded by O({2}31n/96). Finally, when compared to heuristic techniques for Exact Satisfiability problems, the proposed quantum algorithm is faster than the classical WalkSAT and Adiabatic Quantum Optimization for random instances with a density of constraints close to the satisfiability threshold, the regime in which instances are typically the hardest to solve. The proposed quantum algorithm can be straightforwardly extended to the generalized version of the Exact Satisfiability known as Occupation problem. The general version of the algorithm is presented and analyzed.

Worst-case scenario approach to the tsunami hazard assessment for the Apulian coasts (southern Italy)

NASA Astrophysics Data System (ADS)

Armigliato, Alberto; Pagnoni, Gianluca; Zaniboni, Filippo; Tinti, Stefano

2014-05-01

In the framework of the Mediterranean basin, Apulia cannot be counted among the most active areas in terms of earthquake and tsunami activity. Nonetheless, in its northern part, which includes the Gargano peninsula, several earthquakes with magnitudes up to 6.7 occurred historically, some of which were also tsunamigenic. The most famous one is the 30 July 1627 event, which produced extensive inundation in the northern part of Gargano and relevant effects also in some portions of its southern side. Its parent fault is still a matter of debate, since both the inland epicentral location determined by macroseismic studies and the strike-slip dominant focal mechanism inferred from local geology are incompatible with a tsunami excitation capable of producing the effects reported by the coeval sources. Moreover, Apulia is bounded by much more tectonically active and tsunamigenic regions, such as the Dalmatia-Montenegro-Albania coastal belt to the East, the western Hellenic Arc to the South-East and the Calabrian arc to the South-West. Finally, Apulia is located in a strategic position in between eastern and western Europe, involving the installation of crucial international infrastructures, such as the Trans-Adriatic gas pipeline. For all the reasons mentioned above, performing an accurate assessment of the hazard related (at least) to earthquakes and tsunami impact in Apulia represents a need. The OTRIONS project developed a multi-parametric network for this purpose, and in its framework we studied the tsunami hazard along the Apulian coasts by means of a worst-case credible scenario approach. This involved the selection and characterisation of all possible tsunamigenic sources both at local and remote distances: this task was carried out as a shared effort with the Italian national RITMARE project. The recognised sources, mainly retrieved from the published literature and from databases available online, include tectonic faults as well as submarine landslides. The tectonic faults we selected are located mainly in the Gargano region, in the central and southern Adriatic offshore, along the coastal belt ranging from Dalmatia to Albania, in different sectors of the western Hellenic Arc and along the eastern Calabria coasts. The landslide scenario is based on the Pleistocene (circa 25 Ka BP) Gondola slide mapped offshore southern Gargano. Coherently with the worst-case approach, a key problem we faced and discuss here is the definition of the maximum magnitude for all the selected tectonic sources. For all scenarios, the tsunami simulations have been performed by means of the in-house UBO-TSUFD numerical code: the main outputs, that we present and discuss for few selected examples, include wave elevation time series in selected coastal sites, maximum wave amplitudes and wave propagation snapshots over the entire computational domain. Finally, we will go into finer spatial detail by studying the tsunami impact inside two Apulian harbours, namely Brindisi and Otranto, that represent important sites from the industrial and infrastructure point of view.

Managing risk in a challenging financial environment.

PubMed

Kaufman, Kenneth

2008-08-01

Five strategies can help hospital financial leaders balance their organizations' financial and risk positions: Understand the hospital's financial condition; Determine the desired level of risk; Consider total risk; Use a portfolio approach; Explore best-case/worst-case scenarios to measure risk.

Measuring efficiency of university-industry Ph.D. projects using best worst method.

PubMed

Salimi, Negin; Rezaei, Jafar

A collaborative Ph.D. project, carried out by a doctoral candidate, is a type of collaboration between university and industry. Due to the importance of such projects, researchers have considered different ways to evaluate the success, with a focus on the outputs of these projects. However, what has been neglected is the other side of the coin-the inputs. The main aim of this study is to incorporate both the inputs and outputs of these projects into a more meaningful measure called efficiency. A ratio of the weighted sum of outputs over the weighted sum of inputs identifies the efficiency of a Ph.D. The weights of the inputs and outputs can be identified using a multi-criteria decision-making (MCDM) method. Data on inputs and outputs are collected from 51 Ph.D. candidates who graduated from Eindhoven University of Technology. The weights are identified using a new MCDM method called Best Worst Method (BWM). Because there may be differences in the opinion of Ph.D. candidates and supervisors on weighing the inputs and outputs, data for BWM are collected from both groups. It is interesting to see that there are differences in the level of efficiency from the two perspectives, because of the weight differences. Moreover, a comparison between the efficiency scores of these projects and their success scores reveals differences that may have significant implications. A sensitivity analysis divulges the most contributing inputs and outputs.

Computational algebraic geometry for statistical modeling FY09Q2 progress.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, David C.; Rojas, Joseph Maurice; Pebay, Philippe Pierre

2009-03-01

This is a progress report on polynomial system solving for statistical modeling. This is a progress report on polynomial system solving for statistical modeling. This quarter we have developed our first model of shock response data and an algorithm for identifying the chamber cone containing a polynomial system in n variables with n+k terms within polynomial time - a significant improvement over previous algorithms, all having exponential worst-case complexity. We have implemented and verified the chamber cone algorithm for n+3 and are working to extend the implementation to handle arbitrary k. Later sections of this report explain chamber cones inmore » more detail; the next section provides an overview of the project and how the current progress fits into it.« less

A Fully Coupled Multi-Rigid-Body Fuel Slosh Dynamics Model Applied to the Triana Stack

NASA Technical Reports Server (NTRS)

London, K. W.

2001-01-01

A somewhat general multibody model is presented that accounts for energy dissipation associated with fuel slosh and which unifies some of the existing more specialized representations. This model is used to predict the mutation growth time constant for the Triana Spacecraft, or Stack, consisting of the Triana Observatory mated with the Gyroscopic Upper Stage of GUS (includes the solid rocket motor, SRM, booster). At the nominal spin rate of 60 rpm and with 145 kg of hydrazine propellant on board, a time constant of 116 s is predicted for worst case sloshing of a spherical slug model compared to 1,681 s (nominal), 1,043 s (worst case) for sloshing of a three degree of freedom pendulum model.

SU-E-T-452: Impact of Respiratory Motion On Robustly-Optimized Intensity-Modulated Proton Therapy to Treat Lung Cancers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, W; Schild, S; Bues, M

Purpose: We compared conventionally optimized intensity-modulated proton therapy (IMPT) treatment plans against the worst-case robustly optimized treatment plans for lung cancer. The comparison of the two IMPT optimization strategies focused on the resulting plans' ability to retain dose objectives under the influence of patient set-up, inherent proton range uncertainty, and dose perturbation caused by respiratory motion. Methods: For each of the 9 lung cancer cases two treatment plans were created accounting for treatment uncertainties in two different ways: the first used the conventional Method: delivery of prescribed dose to the planning target volume (PTV) that is geometrically expanded from themore » internal target volume (ITV). The second employed the worst-case robust optimization scheme that addressed set-up and range uncertainties through beamlet optimization. The plan optimality and plan robustness were calculated and compared. Furthermore, the effects on dose distributions of the changes in patient anatomy due to respiratory motion was investigated for both strategies by comparing the corresponding plan evaluation metrics at the end-inspiration and end-expiration phase and absolute differences between these phases. The mean plan evaluation metrics of the two groups were compared using two-sided paired t-tests. Results: Without respiratory motion considered, we affirmed that worst-case robust optimization is superior to PTV-based conventional optimization in terms of plan robustness and optimality. With respiratory motion considered, robust optimization still leads to more robust dose distributions to respiratory motion for targets and comparable or even better plan optimality [D95% ITV: 96.6% versus 96.1% (p=0.26), D5% - D95% ITV: 10.0% versus 12.3% (p=0.082), D1% spinal cord: 31.8% versus 36.5% (p =0.035)]. Conclusion: Worst-case robust optimization led to superior solutions for lung IMPT. Despite of the fact that robust optimization did not explicitly account for respiratory motion it produced motion-resistant treatment plans. However, further research is needed to incorporate respiratory motion into IMPT robust optimization.« less

Integrated Safety Risk Reduction Approach to Enhancing Human-Rated Spaceflight Safety

NASA Astrophysics Data System (ADS)

Mikula, J. F. Kip

2005-12-01

This paper explores and defines the current accepted concept and philosophy of safety improvement based on a Reliability enhancement (called here Reliability Enhancement Based Safety Theory [REBST]). In this theory a Reliability calculation is used as a measure of the safety achieved on the program. This calculation may be based on a math model or a Fault Tree Analysis (FTA) of the system, or on an Event Tree Analysis (ETA) of the system's operational mission sequence. In each case, the numbers used in this calculation are hardware failure rates gleaned from past similar programs. As part of this paper, a fictional but representative case study is provided that helps to illustrate the problems and inaccuracies of this approach to safety determination. Then a safety determination and enhancement approach based on hazard, worst case analysis, and safety risk determination (called here Worst Case Based Safety Theory [WCBST]) is included. This approach is defined and detailed using the same example case study as shown in the REBST case study. In the end it is concluded that an approach combining the two theories works best to reduce Safety Risk.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strauss, Henry

This research was mostly concerned with asymmetric vertical displacement event (AVDE) disruptions, which are the worst case scenario for producing a large asymmetric wall force. This is potentially a serious problem in ITER.

ROVER: A prototype active vision system

NASA Astrophysics Data System (ADS)

Coombs, David J.; Marsh, Brian D.

1987-08-01

The Roving Eyes project is an experiment in active vision. We present the design and implementation of a prototype that tracks colored balls in images from an on-line charge coupled device (CCD) camera. Rover is designed to keep up with its rapidly changing environment by handling best and average case conditions and ignoring the worst case. This allows Rover's techniques to be less sophisticated and consequently faster. Each of Rover's major functional units is relatively isolated from the others, and an executive which knows all the functional units directs the computation by deciding which jobs would be most effective to run. This organization is realized with a priority queue of jobs and their arguments. Rover's structure not only allows it to adapt its strategy to the environment, but also makes the system extensible. A capability can be added to the system by adding a functional module with a well defined interface and by modifying the executive to make use of the new module. The current implementation is discussed in the appendices.

Multiple usage of the CD PLUS/UNIX system: performance in practice.

PubMed Central

Volkers, A C; Tjiam, I A; van Laar, A; Bleeker, A

1995-01-01

In August 1994, the CD PLUS/Ovid literature retrieval system based on UNIX was activated for the Faculty of Medicine and Health Sciences of Erasmus University in Rotterdam, the Netherlands. There were up to 1,200 potential users. Tests were carried out to determine the extent to which searching for literature was affected by other end users of the system. In the tests, search times and download times were measured in relation to a varying number of continuously active workstations. Results indicated a linear relationship between search times and the number of active workstations. In the "worst case" situation with sixteen active workstations, the time required for record retrieval increased by a factor of sixteen and downloading time by a factor of sixteen over the "best case" of no other active stations. However, because the worst case seldom, if ever, happens in real life, these results are considered acceptable. PMID:8547902

Multiple usage of the CD PLUS/UNIX system: performance in practice.

PubMed

Volkers, A C; Tjiam, I A; van Laar, A; Bleeker, A

1995-10-01

In August 1994, the CD PLUS/Ovid literature retrieval system based on UNIX was activated for the Faculty of Medicine and Health Sciences of Erasmus University in Rotterdam, the Netherlands. There were up to 1,200 potential users. Tests were carried out to determine the extent to which searching for literature was affected by other end users of the system. In the tests, search times and download times were measured in relation to a varying number of continuously active workstations. Results indicated a linear relationship between search times and the number of active workstations. In the "worst case" situation with sixteen active workstations, the time required for record retrieval increased by a factor of sixteen and downloading time by a factor of sixteen over the "best case" of no other active stations. However, because the worst case seldom, if ever, happens in real life, these results are considered acceptable.

'Worst case' methodology for the initial assessment of societal risk from proposed major accident installations.

PubMed

Carter, D A; Hirst, I L

2000-01-07

This paper considers the application of one of the weighted risk indicators used by the Major Hazards Assessment Unit (MHAU) of the Health and Safety Executive (HSE) in formulating advice to local planning authorities on the siting of new major accident hazard installations. In such cases the primary consideration is to ensure that the proposed installation would not be incompatible with existing developments in the vicinity, as identified by the categorisation of the existing developments and the estimation of individual risk values at those developments. In addition a simple methodology, described here, based on MHAU's "Risk Integral" and a single "worst case" even analysis, is used to enable the societal risk aspects of the hazardous installation to be considered at an early stage of the proposal, and to determine the degree of analysis that will be necessary to enable HSE to give appropriate advice.

Ground Plane and Near-Surface Thermal Analysis for NASA's Constellation Program

NASA Technical Reports Server (NTRS)

Gasbarre, Joseph F.; Amundsen, Ruth M.; Scola, Salvatore; Leahy, Frank F.; Sharp, John R.

2008-01-01

Most spacecraft thermal analysis tools assume that the spacecraft is in orbit around a planet and are designed to calculate solar and planetary fluxes, as well as radiation to space. On NASA Constellation projects, thermal analysts are also building models of vehicles in their pre-launch condition on the surface of a planet. This process entails making some modifications in the building and execution of a thermal model such that the radiation from the planet, both reflected albedo and infrared, is calculated correctly. Also important in the calculation of pre-launch vehicle temperatures are the natural environments at the vehicle site, including air and ground temperatures, sky radiative background temperature, solar flux, and optical properties of the ground around the vehicle. A group of Constellation projects have collaborated on developing a cohesive, integrated set of natural environments that accurately capture worst-case thermal scenarios for the pre-launch and launch phases of these vehicles. The paper will discuss the standardization of methods for local planet modeling across Constellation projects, as well as the collection and consolidation of natural environments for launch sites. Methods for Earth as well as lunar sites will be discussed.

E-Assessment within the Bologna Paradigm: Evidence from Portugal

ERIC Educational Resources Information Center

Ferrao, Maria

2010-01-01

The Bologna Declaration brought reforms into higher education that imply changes in teaching methods, didactic materials and textbooks, infrastructures and laboratories, etc. Statistics and mathematics are disciplines that traditionally have the worst success rates, particularly in non-mathematics core curricula courses. This research project,…

Improving Life-Cycle Cost Management of Spacecraft Missions

NASA Technical Reports Server (NTRS)

Clardy, Dennon

2010-01-01

This presentation will explore the results of a recent NASA Life-Cycle Cost study and how project managers can use the findings and recommendations to improve planning and coordination early in the formulation cycle and avoid common pitfalls resulting in cost overruns. The typical NASA space science mission will exceed both the initial estimated and the confirmed life-cycle costs by the end of the mission. In a fixed-budget environment, these overruns translate to delays in starting or launching future missions, or in the worst case can lead to cancelled missions. Some of these overruns are due to issues outside the control of the project; others are due to the unpredictable problems (unknown unknowns) that can affect any development project. However, a recent study of life-cycle cost growth by the Discovery and New Frontiers Program Office identified a number of areas that are within the scope of project management to address. The study also found that the majority of the underlying causes for cost overruns are embedded in the project approach during the formulation and early design phases, but the actual impacts typically are not experienced until late in the project life cycle. Thus, project management focus in key areas such as integrated schedule development, management structure and contractor communications processes, heritage and technology assumptions, and operations planning, can be used to validate initial cost assumptions and set in place management processes to avoid the common pitfalls resulting in cost overruns.

40 CFR 90.119 - Certification procedure-testing.

Code of Federal Regulations, 2010 CFR

2010-07-01

... must select the duty cycle that will result in worst-case emission results for certification. For any... facility, in which case instrumentation and equipment specified by the Administrator must be made available... manufacturers may not use any equipment, instruments, or tools to identify malfunctioning, maladjusted, or...

From up to date climate and ocean evidence with updated UN emissions projections, the time is now to recommend an immediate massive effort on CO2.

NASA Astrophysics Data System (ADS)

Carter, Peter

2017-04-01

This paper provides further compelling evidence for 'an immediate, massive effort to control CO2 emissions, stopped by mid-century' (Cai, Lenton & Lontzek, 2016). Atmospheric CO2 which is above 405 ppm (actual and trend) still accelerating, despite flat emissions since 2014, with a 2015 >3ppm unprecedented spike in Earth history (A. Glikson),is on the worst case IPCC scenario. Atmospheric methane is increasing faster than its past 20-year rate, almost on the worst-case IPCC AR5 scenario (Global Carbon Project, 2016). Observed effects of atmospheric greenhouse gas (GHG) pollution are increasing faster. This includes long-lived atmospheric GHG concentrations, radiative forcing, surface average warming, Greenland ice sheet melting, Arctic daily sea ice anomaly, ocean heat (and rate of going deeper), ocean acidification, and ocean de-oxygenation. The atmospheric GHG concentration of 485 ppm CO2 eq (WMO, 2015) commits us to 'about 2°C' equilibrium (AR5). 2°C by 2100 would require 'substantial emissions reductions over the next few decades' (AR5). Instead, the May 2016 UN update on 'intended' national emissions targets under the Paris Agreement projects global emissions will be 16% higher by 2030 and the November 2016 International Energy Agency update projects energy-related CO2 eq emissions will be 30% higher by 2030, leading to 'around 2.7°C by 2100 and above 3°C thereafter'. Climate change feedback will be positive this century and multiple large vulnerable sources of amplifying feedback exist (AR5). 'Extensive tree mortality and widespread forest die-back linked to drought and temperature stress have been documented on all vegetated continents' (AR5). 'Recent studies suggest a weakening of the land sink, further amplifying atmospheric growth of CO2' (WMO, 2016). Under all but the best-case IPCC AR5 scenario, surface temperature is projected to increase above 2°C by 2100, which is above 3°C (equilibrium) after 2100, with ocean acidification still increasing at 2100. Ocean heat is increasing under all scenarios at 2100. For all producing regions 'With or without adaptation, negative impacts on average crop yields become likely from the 2030s' (AR5). Crop models do not capture all adverse effects. The climate change of 2030 is practically locked in. NASA NEX downscaled daily maximum temperature projections at 1.5°C are incompatible with today's crop yields in major agricultural regions. Climate-change-related impacts from extreme events are high at 1.5°C (AR5) and add to modeled crop declines. 'Some unique and threatened systems are already at risk from climate change (high confidence)' with 'risk of severe consequences' higher with warming of around 1.5°C (AR5). At today's surface temperature increase, 'risks associated with tipping points become moderate' and 'increase disproportionately' as temperature increases above 1.5°C (AR5). According to mitigation projections, global emissions would decline forthwith for a better than 66% chance of a 2°C limit by 2100 (over 3°C after 2100). Failure to do so would risk the future sustainability of civilization and the human population. The IPCC does not make recommendations so this falls on scientists. By recommending immediate (emergency) massive action on CO2, the science community would make a momentous contribution to the future of humanity.

Level II scour analysis for Bridge 81 (MARSUS00020081) on U.S. Highway 2, crossing the Winooski River, Marshfield, Vermont

USGS Publications Warehouse

Ivanoff, Michael A.

1997-01-01

Contraction scour for all modelled flows ranged from 2.1 to 4.2 ft. The worst-case contraction scour occurred at the 500-year discharge. Left abutment scour ranged from 14.3 to 14.4 ft. The worst-case left abutment scour occurred at the incipient roadwayovertopping and 500-year discharge. Right abutment scour ranged from 15.3 to 18.5 ft. The worst-case right abutment scour occurred at the 100-year and the incipient roadwayovertopping discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) give “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

In situ LTE exposure of the general public: Characterization and extrapolation.

PubMed

Joseph, Wout; Verloock, Leen; Goeminne, Francis; Vermeeren, Günter; Martens, Luc

2012-09-01

In situ radiofrequency (RF) exposure of the different RF sources is characterized in Reading, United Kingdom, and an extrapolation method to estimate worst-case long-term evolution (LTE) exposure is proposed. All electric field levels satisfy the International Commission on Non-Ionizing Radiation Protection (ICNIRP) reference levels with a maximal total electric field value of 4.5 V/m. The total values are dominated by frequency modulation (FM). Exposure levels for LTE of 0.2 V/m on average and 0.5 V/m maximally are obtained. Contributions of LTE to the total exposure are limited to 0.4% on average. Exposure ratios from 0.8% (LTE) to 12.5% (FM) are obtained. An extrapolation method is proposed and validated to assess the worst-case LTE exposure. For this method, the reference signal (RS) and secondary synchronization signal (S-SYNC) are measured and extrapolated to the worst-case value using an extrapolation factor. The influence of the traffic load and output power of the base station on in situ RS and S-SYNC signals are lower than 1 dB for all power and traffic load settings, showing that these signals can be used for the extrapolation method. The maximal extrapolated field value for LTE exposure equals 1.9 V/m, which is 32 times below the ICNIRP reference levels for electric fields. Copyright © 2012 Wiley Periodicals, Inc.

Worst-Case Energy Efficiency Maximization in a 5G Massive MIMO-NOMA System.

PubMed

Chinnadurai, Sunil; Selvaprabhu, Poongundran; Jeong, Yongchae; Jiang, Xueqin; Lee, Moon Ho

2017-09-18

In this paper, we examine the robust beamforming design to tackle the energy efficiency (EE) maximization problem in a 5G massive multiple-input multiple-output (MIMO)-non-orthogonal multiple access (NOMA) downlink system with imperfect channel state information (CSI) at the base station. A novel joint user pairing and dynamic power allocation (JUPDPA) algorithm is proposed to minimize the inter user interference and also to enhance the fairness between the users. This work assumes imperfect CSI by adding uncertainties to channel matrices with worst-case model, i.e., ellipsoidal uncertainty model (EUM). A fractional non-convex optimization problem is formulated to maximize the EE subject to the transmit power constraints and the minimum rate requirement for the cell edge user. The designed problem is difficult to solve due to its nonlinear fractional objective function. We firstly employ the properties of fractional programming to transform the non-convex problem into its equivalent parametric form. Then, an efficient iterative algorithm is proposed established on the constrained concave-convex procedure (CCCP) that solves and achieves convergence to a stationary point of the above problem. Finally, Dinkelbach's algorithm is employed to determine the maximum energy efficiency. Comprehensive numerical results illustrate that the proposed scheme attains higher worst-case energy efficiency as compared with the existing NOMA schemes and the conventional orthogonal multiple access (OMA) scheme.

MP3 player listening sound pressure levels among 10 to 17 year old students.

PubMed

Keith, Stephen E; Michaud, David S; Feder, Katya; Haider, Ifaz; Marro, Leonora; Thompson, Emma; Marcoux, Andre M

2011-11-01

Using a manikin, equivalent free-field sound pressure level measurements were made from the portable digital audio players of 219 subjects, aged 10 to 17 years (93 males) at their typical and "worst-case" volume levels. Measurements were made in different classrooms with background sound pressure levels between 40 and 52 dBA. After correction for the transfer function of the ear, the median equivalent free field sound pressure levels and interquartile ranges (IQR) at typical and worst-case volume settings were 68 dBA (IQR = 15) and 76 dBA (IQR = 19), respectively. Self-reported mean daily use ranged from 0.014 to 12 h. When typical sound pressure levels were considered in combination with the average daily duration of use, the median noise exposure level, Lex, was 56 dBA (IQR = 18) and 3.2% of subjects were estimated to exceed the most protective occupational noise exposure level limit in Canada, i.e., 85 dBA Lex. Under worst-case listening conditions, 77.6% of the sample was estimated to listen to their device at combinations of sound pressure levels and average daily durations for which there is no known risk of permanent noise-induced hearing loss, i.e., ≤  75 dBA Lex. Sources and magnitudes of measurement uncertainties are also discussed.

Worst-Case Energy Efficiency Maximization in a 5G Massive MIMO-NOMA System

PubMed Central

Jeong, Yongchae; Jiang, Xueqin; Lee, Moon Ho

2017-01-01

In this paper, we examine the robust beamforming design to tackle the energy efficiency (EE) maximization problem in a 5G massive multiple-input multiple-output (MIMO)-non-orthogonal multiple access (NOMA) downlink system with imperfect channel state information (CSI) at the base station. A novel joint user pairing and dynamic power allocation (JUPDPA) algorithm is proposed to minimize the inter user interference and also to enhance the fairness between the users. This work assumes imperfect CSI by adding uncertainties to channel matrices with worst-case model, i.e., ellipsoidal uncertainty model (EUM). A fractional non-convex optimization problem is formulated to maximize the EE subject to the transmit power constraints and the minimum rate requirement for the cell edge user. The designed problem is difficult to solve due to its nonlinear fractional objective function. We firstly employ the properties of fractional programming to transform the non-convex problem into its equivalent parametric form. Then, an efficient iterative algorithm is proposed established on the constrained concave-convex procedure (CCCP) that solves and achieves convergence to a stationary point of the above problem. Finally, Dinkelbach’s algorithm is employed to determine the maximum energy efficiency. Comprehensive numerical results illustrate that the proposed scheme attains higher worst-case energy efficiency as compared with the existing NOMA schemes and the conventional orthogonal multiple access (OMA) scheme. PMID:28927019

Level II scour analysis for Bridge 7 (CHARTH00010007) on Town Highway 1, crossing Mad Brook, Charleston, Vermont

USGS Publications Warehouse

Boehmler, Erick M.; Weber, Matthew A.

1997-01-01

Contraction scour for all modelled flows ranged from 0.0 to 0.3 ft. The worst-case contraction scour occurred at the incipient overtopping discharge, which was less than the 100-year discharge. Abutment scour ranged from 6.2 to 9.4 ft. The worst-case abutment scour for the right abutment was 9.4 feet at the 100-year discharge. The worst-case abutment scour for the left abutment was 8.6 feet at the incipient overtopping discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 16, (NEWBTH00500016) on Town Highway 50, crossing Halls Brook, Newbury, Vermont

USGS Publications Warehouse

Burns, Ronda L.; Degnan, James R.

1997-01-01

Contraction scour for all modelled flows ranged from 2.6 to 4.6 ft. The worst-case contraction scour occurred at the incipient roadway-overtopping discharge. The left abutment scour ranged from 11.6 to 12.1 ft. The worst-case left abutment scour occurred at the incipient road-overtopping discharge. The right abutment scour ranged from 13.6 to 17.9 ft. The worst-case right abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in Tables 1 and 2. A cross-section of the scour computed at the bridge is presented in Figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 46). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Adhesive strength of total knee endoprostheses to bone cement - analysis of metallic and ceramic femoral components under worst-case conditions.

PubMed

Bergschmidt, Philipp; Dammer, Rebecca; Zietz, Carmen; Finze, Susanne; Mittelmeier, Wolfram; Bader, Rainer

2016-06-01

Evaluation of the adhesive strength of femoral components to the bone cement is a relevant parameter for predicting implant safety. In the present experimental study, three types of cemented femoral components (metallic, ceramic and silica/silane-layered ceramic) of the bicondylar Multigen Plus knee system, implanted on composite femora were analysed. A pull-off test with the femoral components was performed after different load and several cementing conditions (four groups and n=3 components of each metallic, ceramic and silica/silane-layered ceramic in each group). Pull-off forces were comparable for the metallic and the silica/silane-layered ceramic femoral components (mean 4769 N and 4298 N) under standard test condition, whereas uncoated ceramic femoral components showed reduced pull-off forces (mean 2322 N). Loading under worst-case conditions led to decreased adhesive strength by loosening of the interface implant and bone cement using uncoated metallic and ceramic femoral components, respectively. Silica/silane-coated ceramic components were stably fixed even under worst-case conditions. Loading under high flexion angles can induce interfacial tensile stress, which could promote early implant loosening. In conclusion, a silica/silane-coating layer on the femoral component increased their adhesive strength to bone cement. Thicker cement mantles (>2 mm) reduce adhesive strength of the femoral component and can increase the risk of cement break-off.

Validation of a contemporary prostate cancer grading system using prostate cancer death as outcome.

PubMed

Berney, Daniel M; Beltran, Luis; Fisher, Gabrielle; North, Bernard V; Greenberg, David; Møller, Henrik; Soosay, Geraldine; Scardino, Peter; Cuzick, Jack

2016-05-10

Gleason scoring (GS) has major deficiencies and a novel system of five grade groups (GS⩽6; 3+4; 4+3; 8; ⩾9) has been recently agreed and included in the WHO 2016 classification. Although verified in radical prostatectomies using PSA relapse for outcome, it has not been validated using prostate cancer death as an outcome in biopsy series. There is debate whether an 'overall' or 'worst' GS in biopsies series should be used. Nine hundred and eighty-eight prostate cancer biopsy cases were identified between 1990 and 2003, and treated conservatively. Diagnosis and grade was assigned to each core as well as an overall grade. Follow-up for prostate cancer death was until 31 December 2012. A log-rank test assessed univariable differences between the five grade groups based on overall and worst grade seen, and using univariable and multivariable Cox proportional hazards. Regression was used to quantify differences in outcome. Using both 'worst' and 'overall' GS yielded highly significant results on univariate and multivariate analysis with overall GS slightly but insignificantly outperforming worst GS. There was a strong correlation with the five grade groups and prostate cancer death. This is the largest conservatively treated prostate cancer cohort with long-term follow-up and contemporary assessment of grade. It validates the formation of five grade groups and suggests that the 'worst' grade is a valid prognostic measure.

Command and Control Software Development Memory Management

NASA Technical Reports Server (NTRS)

Joseph, Austin Pope

2017-01-01

This internship was initially meant to cover the implementation of unit test automation for a NASA ground control project. As is often the case with large development projects, the scope and breadth of the internship changed. Instead, the internship focused on finding and correcting memory leaks and errors as reported by a COTS software product meant to track such issues. Memory leaks come in many different flavors and some of them are more benign than others. On the extreme end a program might be dynamically allocating memory and not correctly deallocating it when it is no longer in use. This is called a direct memory leak and in the worst case can use all the available memory and crash the program. If the leaks are small they may simply slow the program down which, in a safety critical system (a system for which a failure or design error can cause a risk to human life), is still unacceptable. The ground control system is managed in smaller sub-teams, referred to as CSCIs. The CSCI that this internship focused on is responsible for monitoring the health and status of the system. This team's software had several methods/modules that were leaking significant amounts of memory. Since most of the code in this system is safety-critical, correcting memory leaks is a necessity.

Stochastic Robust Mathematical Programming Model for Power System Optimization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Cong; Changhyeok, Lee; Haoyong, Chen

2016-01-01

This paper presents a stochastic robust framework for two-stage power system optimization problems with uncertainty. The model optimizes the probabilistic expectation of different worst-case scenarios with ifferent uncertainty sets. A case study of unit commitment shows the effectiveness of the proposed model and algorithms.

Minimax Quantum Tomography: Estimators and Relative Entropy Bounds

DOE PAGES

Ferrie, Christopher; Blume-Kohout, Robin

2016-03-04

A minimax estimator has the minimum possible error (“risk”) in the worst case. Here we construct the first minimax estimators for quantum state tomography with relative entropy risk. The minimax risk of nonadaptive tomography scales as O (1/more » $$\\sqrt{N}$$ ) —in contrast to that of classical probability estimation, which is O (1/N) —where N is the number of copies of the quantum state used. We trace this deficiency to sampling mismatch: future observations that determine risk may come from a different sample space than the past data that determine the estimate. Lastly, this makes minimax estimators very biased, and we propose a computationally tractable alternative with similar behavior in the worst case, but superior accuracy on most states.« less

Charging and discharging characteristics of dielectric materials exposed to low- and mid-energy electrons

NASA Technical Reports Server (NTRS)

Coakley, P.; Kitterer, B.; Treadaway, M.

1982-01-01

Charging and discharging characteristics of dielectric samples exposed to 1-25 keV and 25-100 keV electrons in a laboratory environment are reported. The materials examined comprised OSR, Mylar, Kapton, perforated Kapton, and Alphaquartz, serving as models for materials employed on spacecraft in geosynchronous orbit. The tests were performed in a vacuum chamber with electron guns whose beams were rastered over the entire surface of the planar samples. The specimens were examined in low-impedance-grounded, high-impedance-grounded, and isolated configurations. The worst-case and average peak discharge currents were observed to be independent of the incident electron energy, the time-dependent changes in the worst case discharge peak current were independent of the energy, and predischarge surface potentials are negligibly dependent on incident monoenergetic electrons.

Worst-case space radiation environments for geocentric missions

NASA Technical Reports Server (NTRS)

Stassinopoulos, E. G.; Seltzer, S. M.

1976-01-01

Worst-case possible annual radiation fluences of energetic charged particles in the terrestrial space environment, and the resultant depth-dose distributions in aluminum, were calculated in order to establish absolute upper limits to the radiation exposure of spacecraft in geocentric orbits. The results are a concise set of data intended to aid in the determination of the feasibility of a particular mission. The data may further serve as guidelines in the evaluation of standard spacecraft components. Calculations were performed for each significant particle species populating or visiting the magnetosphere, on the basis of volume occupied by or accessible to the respective species. Thus, magnetospheric space was divided into five distinct regions using the magnetic shell parameter L, which gives the approximate geocentric distance (in earth radii) of a field line's equatorial intersect.

``Carbon Credits'' for Resource-Bounded Computations Using Amortised Analysis

NASA Astrophysics Data System (ADS)

Jost, Steffen; Loidl, Hans-Wolfgang; Hammond, Kevin; Scaife, Norman; Hofmann, Martin

Bounding resource usage is important for a number of areas, notably real-time embedded systems and safety-critical systems. In this paper, we present a fully automatic static type-based analysis for inferring upper bounds on resource usage for programs involving general algebraic datatypes and full recursion. Our method can easily be used to bound any countable resource, without needing to revisit proofs. We apply the analysis to the important metrics of worst-case execution time, stack- and heap-space usage. Our results from several realistic embedded control applications demonstrate good matches between our inferred bounds and measured worst-case costs for heap and stack usage. For time usage we infer good bounds for one application. Where we obtain less tight bounds, this is due to the use of software floating-point libraries.

Hepatitis Aand E Co-Infection with Worst Outcome.

PubMed

Saeed, Anjum; Cheema, Huma Arshad; Assiri, Asaad

2016-06-01

Infections are still a major problem in the developing countries like Pakistan because of poor sewage disposal and economic restraints. Acute viral hepatitis like Aand E are not uncommon in pediatric age group because of unhygienic food handling and poor sewage disposal, but majority recovers well without any complications. Co-infections are rare occurrences and physicians need to be well aware while managing such conditions to avoid worst outcome. Co-infection with hepatitis Aand E is reported occasionally in the literature, however, other concurrent infections such as hepatitis A with Salmonellaand hepatotropic viruses like viral hepatitis B and C are present in the literature. Co-infections should be kept in consideration when someone presents with atypical symptoms or unusual disease course like this presented case. We report here a girl child who had acute hepatitis A and E concurrent infections and presented with hepatic encephalopathy and had worst outcome, despite all the supportive measures being taken.

Implementation of School Health Promotion: Consequences for Professional Assistance

ERIC Educational Resources Information Center

Boot, N. M. W. M.; de Vries, N. K.

2012-01-01

Purpose: This case study aimed to examine the factors influencing the implementation of health promotion (HP) policies and programs in secondary schools and the consequences for professional assistance. Design/methodology/approach: Group interviews were held in two schools that represented the best and worst case of implementation of a health…

Compression in the Superintendent Ranks

ERIC Educational Resources Information Center

Saron, Bradford G.; Birchbauer, Louis J.

2011-01-01

Sadly, the fiscal condition of school systems now not only is troublesome, but in some cases has surpassed all expectations for the worst-case scenario. Among the states, one common response is to drop funding for public education to inadequate levels, leading to permanent program cuts, school closures, staff layoffs, district dissolutions and…

Quality management for space systems in ISRO

NASA Astrophysics Data System (ADS)

Satish, S.; Selva Raju, S.; Nanjunda Swamy, T. S.; Kulkarni, P. L.

2009-11-01

In a little over four decades, the Indian Space Program has carved a niche for itself with the unique application driven program oriented towards National development. The end-to-end capability approach of the space projects in the country call for innovative practices and procedures in assuring the quality and reliability of space systems. The System Reliability (SR) efforts initiated at the start of the projects continue during the entire life cycle of the project encompassing design, development, realisation, assembly, testing and integration and during launch. Even after the launch, SR groups participate in the on-orbit evaluation of transponders in communication satellites and camera systems in remote sensing satellites. SR groups play a major role in identification, evaluation and inculcating quality practices in work centres involved in the fabrication of mechanical, electronics and propulsion systems required for Indian Space Research Organization's (ISRO's) launch vehicle and spacecraft projects. Also the reliability analysis activities like prediction, assessment and demonstration as well as de-rating analysis, Failure Mode Effects and Criticality Analysis (FMECA) and worst-case analysis are carried out by SR groups during various stages of project realisation. These activities provide the basis for project management to take appropriate techno-managerial decisions to ensure that the required reliability goals are met. Extensive test facilities catering to the needs of the space program has been set up. A system for consolidating the experience and expertise gained for issue of standards called product assurance specifications to be used in all ISRO centres has also been established.

Preliminary Radiation Analysis of the Total Ionizing Dose for the Resource Prospector Mission

NASA Technical Reports Server (NTRS)

Rojdev, Kristina; Tylka, Allan J.; Atwell, William

2015-01-01

NASA's Resource Prospector (RP) is a collaborative project between multiple centers and institutions to search for volatiles at the polar regions of the Moon as a potential resource for oxygen and propellant production. The mission is rated Class D and will be the first In-Situ Resource Utilization (ISRU) demonstration on the lunar surface and at the lunar poles. Given that this mission is rated Class D, the project is considering using commercial off the shelf (COTS) electronics parts to reduce cost. However, COTS parts can be more susceptible to space radiation than typical aerospace electronic parts and carry some additional risk. Thus, prior to parts selection, having a better understanding of the radiation environment can assist designers in the parts selection process. The focus of this paper is to provide a preliminary analysis of the radiation environment from launch, through landing on the surface, and some surface stay as an initial step in determining worst case mission doses to assist designers in screening out electronic parts that would not meet the potential dose levels experienced on this mission.

A Low Power SOC Architecture for the V2.0+EDR Bluetooth Using a Unified Verification Platform

NASA Astrophysics Data System (ADS)

Kim, Jeonghun; Kim, Suki; Baek, Kwang-Hyun

This paper presents a low-power System on Chip (SOC) architecture for the v2.0+EDR (Enhanced Data Rate) Bluetooth and its applications. Our design includes a link controller, modem, RF transceiver, Sub-Band Codec (SBC), Expanded Instruction Set Computer (ESIC) processor, and peripherals. To decrease power consumption of the proposed SOC, we reduce data transfer using a dual-port memory, including a power management unit, and a clock gated approach. We also address some of issues and benefits of reusable and unified environment on a centralized data structure and SOC verification platform. This includes flexibility in meeting the final requirements using technology-independent tools wherever possible in various processes and for projects. The other aims of this work are to minimize design efforts by avoiding the same work done twice by different people and to reuse the similar environment and platform for different projects. This chip occupies a die size of 30mm2 in 0.18µm CMOS, and the worst-case current of the total chip is 54mA.

40 CFR 85.2115 - Notification of intent to certify.

Code of Federal Regulations, 2013 CFR

2013-07-01

... testing and durability demonstration represent worst case with respect to emissions of all those... submitted by the aftermarket manufacturer to: Mod Director, MOD (EN-340F), Attention: Aftermarket Parts, 401...

40 CFR 85.2115 - Notification of intent to certify.

Code of Federal Regulations, 2012 CFR

2012-07-01

... testing and durability demonstration represent worst case with respect to emissions of all those... submitted by the aftermarket manufacturer to: Mod Director, MOD (EN-340F), Attention: Aftermarket Parts, 401...

40 CFR 85.2115 - Notification of intent to certify.

Code of Federal Regulations, 2014 CFR

2014-07-01

... testing and durability demonstration represent worst case with respect to emissions of all those... submitted by the aftermarket manufacturer to: Mod Director, MOD (EN-340F), Attention: Aftermarket Parts, 401...

10 CFR 434.501 - General.

Code of Federal Regulations, 2011 CFR

2011-01-01

... size and type will vary only with climate, the number of stories, and the choice of simulation tool... practice for some climates or buildings, but represent a reasonable worst case of energy cost resulting...

10 CFR 434.501 - General.

Code of Federal Regulations, 2012 CFR

2012-01-01

... size and type will vary only with climate, the number of stories, and the choice of simulation tool... practice for some climates or buildings, but represent a reasonable worst case of energy cost resulting...

10 CFR 434.501 - General.

Code of Federal Regulations, 2013 CFR

2013-01-01

... size and type will vary only with climate, the number of stories, and the choice of simulation tool... practice for some climates or buildings, but represent a reasonable worst case of energy cost resulting...

10 CFR 434.501 - General.

Code of Federal Regulations, 2014 CFR

2014-01-01

... size and type will vary only with climate, the number of stories, and the choice of simulation tool... practice for some climates or buildings, but represent a reasonable worst case of energy cost resulting...

10 CFR 434.501 - General.

Code of Federal Regulations, 2010 CFR

2010-01-01

... size and type will vary only with climate, the number of stories, and the choice of simulation tool... practice for some climates or buildings, but represent a reasonable worst case of energy cost resulting...

Adaptive Attitude Control of the Crew Launch Vehicle

NASA Technical Reports Server (NTRS)

Muse, Jonathan

2010-01-01

An H(sub infinity)-NMA architecture for the Crew Launch Vehicle was developed in a state feedback setting. The minimal complexity adaptive law was shown to improve base line performance relative to a performance metric based on Crew Launch Vehicle design requirements for all most all of the Worst-on-Worst dispersion cases. The adaptive law was able to maintain stability for some dispersions that are unstable with the nominal control law. Due to the nature of the H(sub infinity)-NMA architecture, the augmented adaptive control signal has low bandwidth which is a great benefit for a manned launch vehicle.

Lake water quality mapping from Landsat

NASA Technical Reports Server (NTRS)

Scherz, J. P.

1977-01-01

In the project described remote sensing was used to check the quality of lake waters. The lakes of three Landsat scenes were mapped with the Bendix MDAS multispectral analysis system. From the MDAS color coded maps, the lake with the worst algae problem was easily located. The lake was closely checked, and the presence of 100 cows in the springs which fed the lake could be identified as the pollution source. The laboratory and field work involved in the lake classification project is described.

Marjorie C. Chiafery: Righting the Ship by Broadening the Base

ERIC Educational Resources Information Center

Goldman, Jay P.

2005-01-01

In her 27 years as an administrator in Merrimack, New Hampshire, Marge Chiafery can legitimately claim to have seen the best of times and the worst. The high moments were the earlier years when Merrimack's job-sharing initiative, teacher evaluation system and middle school project promoting parent-child communication were emulated statewide. The…

Among Friends: Effective Peer Critiquing.

ERIC Educational Resources Information Center

Dossin, Mary Mortimore

2003-01-01

Describes a project in which the author asked the students to write about either their best classroom experience with writing or their worst. Finds that the most potent influence on writing instruction is the atmosphere of the classroom rather than the techniques that are used. Notes that the single strongest positive influence was the presence of…

Validation of a contemporary prostate cancer grading system using prostate cancer death as outcome

PubMed Central

Berney, Daniel M; Beltran, Luis; Fisher, Gabrielle; North, Bernard V; Greenberg, David; Møller, Henrik; Soosay, Geraldine; Scardino, Peter; Cuzick, Jack

2016-01-01

Background: Gleason scoring (GS) has major deficiencies and a novel system of five grade groups (GS⩽6; 3+4; 4+3; 8; ⩾9) has been recently agreed and included in the WHO 2016 classification. Although verified in radical prostatectomies using PSA relapse for outcome, it has not been validated using prostate cancer death as an outcome in biopsy series. There is debate whether an ‘overall' or ‘worst' GS in biopsies series should be used. Methods: Nine hundred and eighty-eight prostate cancer biopsy cases were identified between 1990 and 2003, and treated conservatively. Diagnosis and grade was assigned to each core as well as an overall grade. Follow-up for prostate cancer death was until 31 December 2012. A log-rank test assessed univariable differences between the five grade groups based on overall and worst grade seen, and using univariable and multivariable Cox proportional hazards. Regression was used to quantify differences in outcome. Results: Using both ‘worst' and ‘overall' GS yielded highly significant results on univariate and multivariate analysis with overall GS slightly but insignificantly outperforming worst GS. There was a strong correlation with the five grade groups and prostate cancer death. Conclusions: This is the largest conservatively treated prostate cancer cohort with long-term follow-up and contemporary assessment of grade. It validates the formation of five grade groups and suggests that the ‘worst' grade is a valid prognostic measure. PMID:27100731

RMP*Comp

EPA Pesticide Factsheets

You can use this free software program to complete the Off-site Consequence Analyses (both worst case scenarios and alternative scenarios) required under the Risk Management Program rule, so that you don't have to do calculations by hand.

49 CFR 194.105 - Worst case discharge.

Code of Federal Regulations, 2013 CFR

2013-10-01

...: Prevention measure Standard Credit(percent) Secondary containment >100% NFPA 30 50 Built/repaired to API standards API STD 620/650/653 10 Overfill protection standards API RP 2350 5 Testing/cathodic protection API...

49 CFR 194.105 - Worst case discharge.

Code of Federal Regulations, 2010 CFR

2010-10-01

...: Prevention measure Standard Credit(percent) Secondary containment > 100% NFPA 30 50 Built/repaired to API standards API STD 620/650/653 10 Overfill protection standards API RP 2350 5 Testing/cathodic protection API...

49 CFR 194.105 - Worst case discharge.

Code of Federal Regulations, 2014 CFR

2014-10-01

...: Prevention measure Standard Credit(percent) Secondary containment >100% NFPA 30 50 Built/repaired to API standards API STD 620/650/653 10 Overfill protection standards API RP 2350 5 Testing/cathodic protection API...

49 CFR 194.105 - Worst case discharge.

Code of Federal Regulations, 2012 CFR

2012-10-01

...: Prevention measure Standard Credit(percent) Secondary containment > 100% NFPA 30 50 Built/repaired to API standards API STD 620/650/653 10 Overfill protection standards API RP 2350 5 Testing/cathodic protection API...

49 CFR 194.105 - Worst case discharge.

Code of Federal Regulations, 2011 CFR

2011-10-01

...: Prevention measure Standard Credit(percent) Secondary containment > 100% NFPA 30 50 Built/repaired to API standards API STD 620/650/653 10 Overfill protection standards API RP 2350 5 Testing/cathodic protection API...

Calculations of the skyshine gamma-ray dose rates from independent spent fuel storage installations (ISFSI) under worst case accident conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pace, J.V. III; Cramer, S.N.; Knight, J.R.

1980-09-01

Calculations of the skyshine gamma-ray dose rates from three spent fuel storage pools under worst case accident conditions have been made using the discrete ordinates code DOT-IV and the Monte Carlo code MORSE and have been compared to those of two previous methods. The DNA 37N-21G group cross-section library was utilized in the calculations, together with the Claiborne-Trubey gamma-ray dose factors taken from the same library. Plots of all results are presented. It was found that the dose was a strong function of the iron thickness over the fuel assemblies, the initial angular distribution of the emitted radiation, and themore » photon source near the top of the assemblies. 16 refs., 11 figs., 7 tabs.« less

Most Probable Fire Scenarios in Spacecraft and Extraterrestrial Habitats: Why NASA's Current Test 1 Might Not Always be Conservative

NASA Technical Reports Server (NTRS)

Olson, S. L.

2004-01-01

NASA's current method of material screening determines fire resistance under conditions representing a worst-case for normal gravity flammability - the Upward Flame Propagation Test (Test 1). Its simple pass-fail criteria eliminates materials that burn for more than 12 inches from a standardized ignition source. In addition, if a material drips burning pieces that ignite a flammable fabric below, it fails. The applicability of Test 1 to fires in microgravity and extraterrestrial environments, however, is uncertain because the relationship between this buoyancy-dominated test and actual extraterrestrial fire hazards is not understood. There is compelling evidence that the Test 1 may not be the worst case for spacecraft fires, and we don t have enough information to assess if it is adequate at Lunar or Martian gravity levels.

Most Probable Fire Scenarios in Spacecraft and Extraterrestrial Habitats: Why NASA's Current Test 1 Might Not Always Be Conservative

NASA Technical Reports Server (NTRS)

Olson, S. L.

2004-01-01

NASA s current method of material screening determines fire resistance under conditions representing a worst-case for normal gravity flammability - the Upward Flame Propagation Test (Test 1[1]). Its simple pass-fail criteria eliminates materials that burn for more than 12 inches from a standardized ignition source. In addition, if a material drips burning pieces that ignite a flammable fabric below, it fails. The applicability of Test 1 to fires in microgravity and extraterrestrial environments, however, is uncertain because the relationship between this buoyancy-dominated test and actual extraterrestrial fire hazards is not understood. There is compelling evidence that the Test 1 may not be the worst case for spacecraft fires, and we don t have enough information to assess if it is adequate at Lunar or Martian gravity levels.

LANDSAT-D MSS/TM tuned orbital jitter analysis model LDS900

NASA Technical Reports Server (NTRS)

Pollak, T. E.

1981-01-01

The final LANDSAT-D orbital dynamic math model (LSD900), comprised of all test validated substructures, was used to evaluate the jitter response of the MSS/TM experiments. A dynamic forced response analysis was performed at both the MSS and TM locations on all structural modes considered (thru 200 Hz). The analysis determined the roll angular response of the MSS/TM experiments to improve excitation generated by component operation. Cross axis and cross experiment responses were also calculated. The excitations were analytically represented by seven and nine term Fourier series approximations, for the MSS and TM experiment respectively, which enabled linear harmonic solution techniques to be applied to response calculations. Single worst case jitter was estimated by variations of the eigenvalue spectrum of model LSD 900. The probability of any worst case mode occurrence was investigated.

Natural Hazards Risk Reduction and the ARkStorm Scenario

NASA Astrophysics Data System (ADS)

Cox, D. A.; Dettinger, M. D.; Ralph, F. M.

2016-12-01

The ARkStorm Scenario project began in 2008, led by the USGS Multi-Hazards Demonstration Project (now Science Application for Risk Reduction) in an effort to innovate the application of science to reduce natural-hazard risk associated with large atmospheric-river (AR) storms on the West Coast of the US. The effort involved contributions from many federal, state and academic organizations including NOAA's Environmental Systems Laboratory. The ARkStorm project used new understanding of atmospheric river physics, combined with downscaled meteorological data from two recent ARs (in 1969 and 1986), to describe and model a prolonged sequence of back-to-back storms similar to those that bankrupted California in 1862. With this scientifically plausible (but not worst-case) scenario, the ARkStorm team engaged flood and levee experts to identify plausible flooding extents and durations, created a coastal-storm inundation model (CoSMoS), and California's first landslide susceptibility map, to better understand secondary meteorological and geophysical hazards (flood, wind, landslide, coastal erosion and inundation) across California. Physical damages to homes, infrastructure, agriculture, and the environment were then estimated to calculate the likely social and economic impact to California and the nation. Across California, property damage from the ARkStorm scenario was estimated to exceed 300 billion, mostly from flooding. Including damage and losses, lifeline damages and business interruptions, the total cost of an ARkStorm-sized series of storms came to nearly 725 billion, nearly three times the losses estimated from another SAFRR scenario describing a M7.8 earthquake in southern California. Thus, atmospheric rivers have the potential to be California's other "Big One." Since its creation, the ARkStorm scenario has been used in preparedness exercises by NASA, the US Navy, the State of California, the County of Ventura, and cities and counties in the Tahoe Basin and downstream into Nevada. These efforts have examined how large AR events could plausibly impact many aspects of society and environment, and how to avoid the worst of the disaster outcomes. The ARkStorm scenario will next be used in a climate extremes scenario for the U.S. Southwest.

An Alaskan Theater Airlift Model.

DTIC Science & Technology

1982-02-19

overt attack on American soil . In any case, such a reaotion represents the worst-case scenario In that theater forces would be denied the advantages of...NNSETNTAFE,SS(l06), USL (100), 7 TNET,THOV,1X(100) REAL A,CHKTIN INTEGER ORIC,DEST,ISCTMP,WXFLG,ALLW,T(RT,ZPTR,ZONE, * FTNFLG.WX,ZONLST(150) DATA ZNSI

78 FR 49831 - Endangered and Threatened Wildlife and Plants; Proposed Designation of Critical Habitat for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-15

... Service (NPS) for the Florida leafwing and the pine rockland ecosystem, in general. Sea Level Rise... habitat. In the best case scenario, which assumes low sea level rise, high financial resources, proactive... human population. In the worst case scenario, which assumes high sea level rise, low financial resources...

A Different Call to Arms: Women in the Core of the Communications Revolution.

ERIC Educational Resources Information Center

Rush, Ramona R.

A "best case" model for the role of women in the postindustrial communications era predicts positive leadership roles based on the preindustrial work characteristics of cooperation and consensus. A "worst case" model finds women entrepreneurs succumbing to the competitive male ethos and extracting the maximum amount of work…

Benefits of investing in ecosystem restoration.

PubMed

DE Groot, Rudolf S; Blignaut, James; VAN DER Ploeg, Sander; Aronson, James; Elmqvist, Thomas; Farley, Joshua

2013-12-01

Measures aimed at conservation or restoration of ecosystems are often seen as net-cost projects by governments and businesses because they are based on incomplete and often faulty cost-benefit analyses. After screening over 200 studies, we examined the costs (94 studies) and benefits (225 studies) of ecosystem restoration projects that had sufficient reliable data in 9 different biomes ranging from coral reefs to tropical forests. Costs included capital investment and maintenance of the restoration project, and benefits were based on the monetary value of the total bundle of ecosystem services provided by the restored ecosystem. Assuming restoration is always imperfect and benefits attain only 75% of the maximum value of the reference systems over 20 years, we calculated the net present value at the social discount rates of 2% and 8%. We also conducted 2 threshold cum sensitivity analyses. Benefit-cost ratios ranged from about 0.05:1 (coral reefs and coastal systems, worst-case scenario) to as much as 35:1 (grasslands, best-case scenario). Our results provide only partial estimates of benefits at one point in time and reflect the lower limit of the welfare benefits of ecosystem restoration because both scarcity of and demand for ecosystem services is increasing and new benefits of natural ecosystems and biological diversity are being discovered. Nonetheless, when accounting for even the incomplete range of known benefits through the use of static estimates that fail to capture rising values, the majority of the restoration projects we analyzed provided net benefits and should be considered not only as profitable but also as high-yielding investments. Beneficios de Invertir en la Restauración de Ecosistemas. © 2013 Society for Conservation Biology.

How well do CMIP5 models simulate the low-level jet in western Colombia?

NASA Astrophysics Data System (ADS)

Sierra, Juan P.; Arias, Paola A.; Vieira, Sara C.; Agudelo, Jhoana

2017-11-01

The Choco jet is an important atmospheric feature of Colombian and northern South America hydro-climatology. This work assesses the ability of 26 coupled and 11 uncoupled (AMIP) global climate models (GCMs) included in the fifth phase of the Coupled Model Intercomparison Project (CMIP5) archive to simulate the climatological basic features (annual cycle, spatial distribution and vertical structure) of this jet. Using factor and cluster analysis, we objectively classify models in Best, Worst, and Intermediate groups. Despite the coarse resolution of the GCMs, this study demonstrates that nearly all models can represent the existence of the Choco low-level jet. AMIP and Best models present a more realistic simulation of jet. Worst models exhibit biases such as an anomalous southward location of the Choco jet during the whole year and a shallower jet. The model skill to represent this jet comes from their ability to reproduce some of its main causes, such as the temperature and pressure differences between particular regions in the eastern Pacific and western Colombian lands, which are non-local features. Conversely, Worst models considerably underestimate temperature and pressure differences between these key regions. We identify a close relationship between the location of the Choco jet and the Inter-tropical Convergence Zone (ITCZ), and CMIP5 models are able to represent such relationship. Errors in Worst models are related with bias in the location of the ITCZ over the eastern tropical Pacific Ocean, as well as the representation of the topography and the horizontal resolution.

The HLA-matching effect in different cohorts of kidney transplant recipients: 10 years later.

PubMed

Sasaki, Nori; Idica, Adam

2010-01-01

Almost all the HLA-matching effects found by the 2000 analysis were confirmed by this study. The only HLA-matching effect found in the 2000 analysis that disappeared were those of "small matching effect" found in sub-populations of type I diabetes (PRA < 10%, donor age 20-35). The 2000 analysis found a lack of HLA matching effect in non-African American kidney transplant patients with type I diabetes between 1987 and 2000. The 2000 analysis found that a patients' ethnic group was a factor in graft survival; African American patients were found to have a significantly lower 10-year graft survival in the 5 or 6 mismatched group (27%) compared to Caucasian patients (40%). In addition, Asian patients (42%) had higher graft survival compared to that of Caucasian patients. In this study, we observe a similar pattern with death-censored graft analysis for all ethnic groups with 10-year graft survivals at 72.9% for Asians, 69.5% for Caucasians, and 49.3% for African Americans. There was an overall lack of HLA-matching effect on patient survival in the 2000 analysis. In our current analysis, the patient survivals remained virtually the same despite moderate increase in graft survival over the same period of time. The HLA-C locus mismatch was found to have additive effect to the 10-year graft survival trends observed in A and B mismatch cases. HLA-DQ mismatch on the other hand, showed limited HLA-matching effect and did not show the same additive effect as C. There are various possible issues in the DQ mismatch analysis, from the consistency of DQ typing results, lack of diversity in the DQ antigen, to the possibility of DQ mismatch having little effect on the graft survival. Utilizing kidney transplant cases performed from 1995 through 2000, the 2000 analysis projected 10-year survivals of 64% and 47% for the 0 ABDR mismatch and 5 or 6 ABDR mismatched cases respectively; the 2000 projection only missed actual death-censored survivals by 9% lower for the 0 mismatch and 17% lower for the 5 or 6 mismatch cases. Utilizing the transplant cases of 2005 through 2009, we projected their 10-year graft survivals for year 2020. The 10-year graft survival for 0 ABDR mismatched patients is expected to be over 85% and nearly 70% for 5 or 6 ABDR mismatched patients. The general upward trend of graft survival we have observed in the last 10 years has been dependent upon the development of novel transplant protocols and use of novel immunomodulatory reagents. This trend is likely to continue given the promise of new drugs and personalized healthcare. The decreasing range of the differences in the 10-year graft survival between best matched and worst matched HLA groups is also likely to continue. One interesting trend that is clearly evident is the increasing difference between the best and worst HLA-matching in terms of the associated graft half-life. The positive HLA-matching effect on long-term graft survival is clearly evident and should be taken into consideration for all kidney transplants.

RMP Guidance for Offsite Consequence Analysis

EPA Pesticide Factsheets

Offsite consequence analysis (OCA) consists of a worst-case release scenario and alternative release scenarios. OCA is required from facilities with chemicals above threshold quantities. RMP*Comp software can be used to perform calculations described here.

Moving from Colonization toward Balance and Harmony: A Native American Perspective on Wellness

ERIC Educational Resources Information Center

Hodge, David R.; Limb, Gordon E.; Cross, Terry L.

2009-01-01

At best, mainstream mental health services are often ineffective with Native American clients, and, at worst, they are a vehicle for Western colonization. As such, the authors explore the notion of abandoning the Western therapeutic project and rebuilding the helping process on the basis of indigenous knowledge foundations. To this end, they…

Experimental Charging Behavior of Orion UltraFlex Array Designs

NASA Technical Reports Server (NTRS)

Golofaro, Joel T.; Vayner, Boris V.; Hillard, Grover B.

2010-01-01

The present ground based investigations give the first definitive look describing the charging behavior of Orion UltraFlex arrays in both the Low Earth Orbital (LEO) and geosynchronous (GEO) environments. Note the LEO charging environment also applies to the International Space Station (ISS). The GEO charging environment includes the bounding case for all lunar mission environments. The UltraFlex photovoltaic array technology is targeted to become the sole power system for life support and on-orbit power for the manned Orion Crew Exploration Vehicle (CEV). The purpose of the experimental tests is to gain an understanding of the complex charging behavior to answer some of the basic performance and survivability issues to ascertain if a single UltraFlex array design will be able to cope with the projected worst case LEO and GEO charging environments. Stage 1 LEO plasma testing revealed that all four arrays successfully passed arc threshold bias tests down to -240 V. Stage 2 GEO electron gun charging tests revealed that only the front side area of indium tin oxide coated array designs successfully passed the arc frequency tests

Tsunami Evacuation Plan for the City of Tangier-Morocco

NASA Astrophysics Data System (ADS)

Benchekroun, Sabah; Omira, Rachid; Baptista, Maria Ana; Arbi Toto, El

2016-04-01

Tsunami evacuation plan is an important tool to mitigate the tsunami impact. It is the most efficient way to save human lives, well before the waves reach the threatened coastal area, by providing evacuation routes and appropriate shelters. In this study, we propose a tsunami evacuation plan for the city of Tangier-Morocco. This plan is designed considering the tsunami threat from the tsunamigenic sources located in the SW Iberia Margin and using the inundation maps of the worst case to define the limit of flooding area. The evacuation plan is elaborated through modelling the required time for the threatened coastal population to reach the shelters. Results of this study will be useful for decision makers and local authorities in preventing the community resiliency for tsunami hazard. This work received funding from collaborative project ASTARTE - Assessment Strategy and Risk Reduction for Tsunamis in Europe Grant 603839, FP7.

Planning Education for Regional Economic Integration: The Case of Paraguay and MERCOSUR.

ERIC Educational Resources Information Center

McGinn, Noel

This paper examines the possible impact of MERCOSUR on Paraguay's economic and educational systems. MERCOSUR is a trade agreement among Argentina, Brazil, Paraguay, and Uruguay, under which terms all import tariffs among the countries will be eliminated by 1994. The countries will enter into a common economic market. The worst-case scenario…

Asteroid Bennu Temperature Maps for OSIRIS-REx Spacecraft and Instrument Thermal Analyses

NASA Technical Reports Server (NTRS)

Choi, Michael K.; Emery, Josh; Delbo, Marco

2014-01-01

A thermophysical model has been developed to generate asteroid Bennu surface temperature maps for OSIRIS-REx spacecraft and instrument thermal design and analyses at the Critical Design Review (CDR). Two-dimensional temperature maps for worst hot and worst cold cases are used in Thermal Desktop to assure adequate thermal design margins. To minimize the complexity of the Bennu geometry in Thermal Desktop, it is modeled as a sphere instead of the radar shape. The post-CDR updated thermal inertia and a modified approach show that the new surface temperature predictions are more benign. Therefore the CDR Bennu surface temperature predictions are conservative.

Availability Simulation of AGT Systems

DOT National Transportation Integrated Search

1975-02-01

The report discusses the analytical and simulation procedures that were used to evaluate the effects of failure in a complex dual mode transportation system based on a worst case study-state condition. The computed results are an availability figure ...

40 CFR 68.25 - Worst-case release scenario analysis.

Code of Federal Regulations, 2013 CFR

2013-07-01

... used is based on TNT equivalent methods. (1) For regulated flammable substances that are normally gases... shall be used to determine the distance to the explosion endpoint if the model used is based on TNT...

40 CFR 68.25 - Worst-case release scenario analysis.

Code of Federal Regulations, 2011 CFR

2011-07-01

... used is based on TNT equivalent methods. (1) For regulated flammable substances that are normally gases... shall be used to determine the distance to the explosion endpoint if the model used is based on TNT...

40 CFR 68.25 - Worst-case release scenario analysis.

Code of Federal Regulations, 2010 CFR

2010-07-01

... used is based on TNT equivalent methods. (1) For regulated flammable substances that are normally gases... shall be used to determine the distance to the explosion endpoint if the model used is based on TNT...

40 CFR 68.25 - Worst-case release scenario analysis.

Code of Federal Regulations, 2012 CFR

2012-07-01

... used is based on TNT equivalent methods. (1) For regulated flammable substances that are normally gases... shall be used to determine the distance to the explosion endpoint if the model used is based on TNT...

40 CFR 68.25 - Worst-case release scenario analysis.

Code of Federal Regulations, 2014 CFR

2014-07-01

... used is based on TNT equivalent methods. (1) For regulated flammable substances that are normally gases... shall be used to determine the distance to the explosion endpoint if the model used is based on TNT...

RMP Guidance for Warehouses - Chapter 4: Offsite Consequence Analysis

EPA Pesticide Factsheets

Offsite consequence analysis (OCA) informs government and the public about potential consequences of an accidental toxic or flammable chemical release at your facility, and consists of a worst-case release scenario and alternative release scenarios.

RMP Guidance for Chemical Distributors - Chapter 4: Offsite Consequence Analysis

EPA Pesticide Factsheets

How to perform the OCA for regulated substances, informing the government and the public about potential consequences of an accidental chemical release at your facility. Includes calculations for worst-case scenario, alternative scenarios, and endpoints.

Gum Disease

MedlinePlus

... damage to the tissue and bone supporting the teeth. In the worst cases, you can lose teeth. In gingivitis, the gums become red and swollen. ... flossing and regular cleanings by a dentist or dental hygienist. Untreated gingivitis can lead to periodontitis. If ...

The Effect of Reaction Control System Thruster Plume Impingement on Orion Service Module Solar Array Power Production

NASA Technical Reports Server (NTRS)

Bury, Kristen M.; Kerslake, Thomas W.

2008-01-01

NASA's new Orion Crew Exploration Vehicle has geometry that orients the reaction control system (RCS) thrusters such that they can impinge upon the surface of Orion's solar array wings (SAW). Plume impingement can cause Paschen discharge, chemical contamination, thermal loading, erosion, and force loading on the SAW surface, especially when the SAWs are in a worst-case orientation (pointed 45 towards the aft end of the vehicle). Preliminary plume impingement assessment methods were needed to determine whether in-depth, timeconsuming calculations were required to assess power loss. Simple methods for assessing power loss as a result of these anomalies were developed to determine whether plume impingement induced power losses were below the assumed contamination loss budget of 2 percent. This paper details the methods that were developed and applies them to Orion's worst-case orientation.

Performance of a normalized energy metric without jammer state information for an FH/MFSK system in worst case partial band jamming

NASA Technical Reports Server (NTRS)

Lee, P. J.

1985-01-01

For a frequency-hopped noncoherent MFSK communication system without jammer state information (JSI) in a worst case partial band jamming environment, it is well known that the use of a conventional unquantized metric results in very poor performance. In this paper, a 'normalized' unquantized energy metric is suggested for such a system. It is shown that with this metric, one can save 2-3 dB in required signal energy over the system with hard decision metric without JSI for the same desired performance. When this very robust metric is compared to the conventional unquantized energy metric with JSI, the loss in required signal energy is shown to be small. Thus, the use of this normalized metric provides performance comparable to systems for which JSI is known. Cutoff rate and bit error rate with dual-k coding are used for the performance measures.

Centaur Propellant Thermal Conditioning Study

NASA Technical Reports Server (NTRS)

Blatt, M. H.; Pleasant, R. L.; Erickson, R. C.

1976-01-01

A wicking investigation revealed that passive thermal conditioning was feasible and provided considerable weight advantage over active systems using throttled vent fluid in a Centaur D-1s launch vehicle. Experimental wicking correlations were obtained using empirical revisions to the analytical flow model. Thermal subcoolers were evaluated parametrically as a function of tank pressure and NPSP. Results showed that the RL10 category I engine was the best candidate for boost pump replacement and the option showing the lowest weight penalty employed passively cooled acquisition devices, thermal subcoolers, dry ducts between burns and pumping of subcooler coolant back into the tank. A mixing correlation was identified for sizing the thermodynamic vent system mixer. Worst case mixing requirements were determined by surveying Centaur D-1T, D-1S, IUS, and space tug vehicles. Vent system sizing was based upon worst case requirements. Thermodynamic vent system/mixer weights were determined for each vehicle.

Updated model assessment of pollution at major U. S. airports

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yamartino, R.J.; Rote, D.M.

1979-02-01

The air quality impact of aircraft at and around Los Angeles International Airport (LAX) was simulated for hours of peak aircraft operation and 'worst case' pollutant dispersion conditions by using an updated version of the Argonne Airport Vicinity Air Pollution model; field programs at LAX, O'Hara, and John F. Kennedy International Airports determined the 'worst case' conditions. Maximum carbon monoxide concentrations at LAX were low relative to National Ambient Air Quality Standards; relatively high and widespread hydrocarbon concentrations indicated that aircraft emissions may aggravate oxidant problems near the airport; nitrogen oxide concentrations were close to the levels set in proposedmore » standards. Data on typical time-in-mode for departing and arriving aircraft, the 8/4/77 diurnal variation in airport activity, and carbon monoxide concentration isopleths are given, and the update factors in the model are discussed.« less

Bristol Ridge: A 28-nm $$\\times$$ 86 Performance-Enhanced Microprocessor Through System Power Management

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sundaram, Sriram; Grenat, Aaron; Naffziger, Samuel

Power management techniques can be effective at extracting more performance and energy efficiency out of mature systems on chip (SoCs). For instance, the peak performance of microprocessors is often limited by worst case technology (Vmax), infrastructure (thermal/electrical), and microprocessor usage assumptions. Performance/watt of microprocessors also typically suffers from guard bands associated with the test and binning processes as well as worst case aging/lifetime degradation. Similarly, on multicore processors, shared voltage rails tend to limit the peak performance achievable in low thread count workloads. In this paper, we describe five power management techniques that maximize the per-part performance under the before-mentionedmore » constraints. Using these techniques, we demonstrate a net performance increase of up to 15% depending on the application and TDP of the SoC, implemented on 'Bristol Ridge,' a 28-nm CMOS, dual-core x 86 accelerated processing unit.« less

VEGA Launch Vehicle Dynamic Environment: Flight Experience and Qualification Status

NASA Astrophysics Data System (ADS)

Di Trapani, C.; Fotino, D.; Mastrella, E.; Bartoccini, D.; Bonnet, M.

2014-06-01

VEGA Launch Vehicle (LV) during flight is equipped with more than 400 sensors (pressure transducers, accelerometers, microphones, strain gauges...) aimed to catch the physical phenomena occurring during the mission. Main objective of these sensors is to verify that the flight conditions are compliant with the launch vehicle and satellite qualification status and to characterize the phenomena that occur during flight. During VEGA development, several test campaigns have been performed in order to characterize its dynamic environment and identify the worst case conditions, but only with the flight data analysis is possible to confirm the worst cases identified and check the compliance of the operative life conditions with the components qualification status.Scope of the present paper is to show a comparison of the sinusoidal dynamic phenomena that occurred during VEGA first and second flight and give a summary of the launch vehicle qualification status.

The Effect of Reaction Control System Thruster Plume Impingement on Orion Service Module Solar Array Power Production

NASA Astrophysics Data System (ADS)

Bury, Kristen M.; Kerslake, Thomas W.

2008-06-01

NASA's new Orion Crew Exploration Vehicle has geometry that orients the reaction control system (RCS) thrusters such that they can impinge upon the surface of Orion's solar array wings (SAW). Plume impingement can cause Paschen discharge, chemical contamination, thermal loading, erosion, and force loading on the SAW surface, especially when the SAWs are in a worst-case orientation (pointed 45 towards the aft end of the vehicle). Preliminary plume impingement assessment methods were needed to determine whether in-depth, timeconsuming calculations were required to assess power loss. Simple methods for assessing power loss as a result of these anomalies were developed to determine whether plume impingement induced power losses were below the assumed contamination loss budget of 2 percent. This paper details the methods that were developed and applies them to Orion's worst-case orientation.

An interior-point method-based solver for simulation of aircraft parts riveting

NASA Astrophysics Data System (ADS)

Stefanova, Maria; Yakunin, Sergey; Petukhova, Margarita; Lupuleac, Sergey; Kokkolaras, Michael

2018-05-01

The particularities of the aircraft parts riveting process simulation necessitate the solution of a large amount of contact problems. A primal-dual interior-point method-based solver is proposed for solving such problems efficiently. The proposed method features a worst case polynomial complexity bound ? on the number of iterations, where n is the dimension of the problem and ε is a threshold related to desired accuracy. In practice, the convergence is often faster than this worst case bound, which makes the method applicable to large-scale problems. The computational challenge is solving the system of linear equations because the associated matrix is ill conditioned. To that end, the authors introduce a preconditioner and a strategy for determining effective initial guesses based on the physics of the problem. Numerical results are compared with ones obtained using the Goldfarb-Idnani algorithm. The results demonstrate the efficiency of the proposed method.

Statistical analysis of QC data and estimation of fuel rod behaviour

NASA Astrophysics Data System (ADS)

Heins, L.; Groβ, H.; Nissen, K.; Wunderlich, F.

1991-02-01

The behaviour of fuel rods while in reactor is influenced by many parameters. As far as fabrication is concerned, fuel pellet diameter and density, and inner cladding diameter are important examples. Statistical analyses of quality control data show a scatter of these parameters within the specified tolerances. At present it is common practice to use a combination of superimposed unfavorable tolerance limits (worst case dataset) in fuel rod design calculations. Distributions are not considered. The results obtained in this way are very conservative but the degree of conservatism is difficult to quantify. Probabilistic calculations based on distributions allow the replacement of the worst case dataset by a dataset leading to results with known, defined conservatism. This is achieved by response surface methods and Monte Carlo calculations on the basis of statistical distributions of the important input parameters. The procedure is illustrated by means of two examples.

A Graph Based Backtracking Algorithm for Solving General CSPs

NASA Technical Reports Server (NTRS)

Pang, Wanlin; Goodwin, Scott D.

2003-01-01

Many AI tasks can be formalized as constraint satisfaction problems (CSPs), which involve finding values for variables subject to constraints. While solving a CSP is an NP-complete task in general, tractable classes of CSPs have been identified based on the structure of the underlying constraint graphs. Much effort has been spent on exploiting structural properties of the constraint graph to improve the efficiency of finding a solution. These efforts contributed to development of a class of CSP solving algorithms called decomposition algorithms. The strength of CSP decomposition is that its worst-case complexity depends on the structural properties of the constraint graph and is usually better than the worst-case complexity of search methods. Its practical application is limited, however, since it cannot be applied if the CSP is not decomposable. In this paper, we propose a graph based backtracking algorithm called omega-CDBT, which shares merits and overcomes the weaknesses of both decomposition and search approaches.

On the Application of Science Systems Engineering and Uncertainty Quantification for Ice Sheet Science and Sea Level Projections

NASA Astrophysics Data System (ADS)

Schlegel, Nicole-Jeanne; Boening, Carmen; Larour, Eric; Limonadi, Daniel; Schodlok, Michael; Seroussi, Helene; Watkins, Michael

2017-04-01

Research and development activities at the Jet Propulsion Laboratory (JPL) currently support the creation of a framework to formally evaluate the observational needs within earth system science. One of the pilot projects of this effort aims to quantify uncertainties in global mean sea level rise projections, due to contributions from the continental ice sheets. Here, we take advantage of established uncertainty quantification tools embedded within the JPL-University of California at Irvine Ice Sheet System Model (ISSM). We conduct sensitivity and Monte-Carlo style sampling experiments on forward simulations of the Greenland and Antarctic ice sheets. By varying internal parameters and boundary conditions of the system over both extreme and credible worst-case ranges, we assess the impact of the different parameter ranges on century-scale sea level rise projections. The results inform efforts to a) isolate the processes and inputs that are most responsible for determining ice sheet contribution to sea level; b) redefine uncertainty brackets for century-scale projections; and c) provide a prioritized list of measurements, along with quantitative information on spatial and temporal resolution, required for reducing uncertainty in future sea level rise projections. Results indicate that ice sheet mass loss is dependent on the spatial resolution of key boundary conditions - such as bedrock topography and melt rates at the ice-ocean interface. This work is performed at and supported by the California Institute of Technology's Jet Propulsion Laboratory. Supercomputing time is also supported through a contract with the National Aeronautics and Space Administration's Cryosphere program.

ASTM F1717 standard for the preclinical evaluation of posterior spinal fixators: can we improve it?

PubMed

La Barbera, Luigi; Galbusera, Fabio; Villa, Tomaso; Costa, Francesco; Wilke, Hans-Joachim

2014-10-01

Preclinical evaluation of spinal implants is a necessary step to ensure their reliability and safety before implantation. The American Society for Testing and Materials reapproved F1717 standard for the assessment of mechanical properties of posterior spinal fixators, which simulates a vertebrectomy model and recommends mimicking vertebral bodies using polyethylene blocks. This set-up should represent the clinical use, but available data in the literature are few. Anatomical parameters depending on the spinal level were compared to published data or measurements on biplanar stereoradiography on 13 patients. Other mechanical variables, describing implant design were considered, and all parameters were investigated using a numerical parametric finite element model. Stress values were calculated by considering either the combination of the average values for each parameter or their worst-case combination depending on the spinal level. The standard set-up represents quite well the anatomy of an instrumented average thoracolumbar segment. The stress on the pedicular screw is significantly influenced by the lever arm of the applied load, the unsupported screw length, the position of the centre of rotation of the functional spine unit and the pedicular inclination with respect to the sagittal plane. The worst-case combination of parameters demonstrates that devices implanted below T5 could potentially undergo higher stresses than those described in the standard suggestions (maximum increase of 22.2% at L1). We propose to revise F1717 in order to describe the anatomical worst case condition we found at L1 level: this will guarantee higher safety of the implant for a wider population of patients. © IMechE 2014.

Learning Search Control Knowledge for Deep Space Network Scheduling

NASA Technical Reports Server (NTRS)

Gratch, Jonathan; Chien, Steve; DeJong, Gerald

1993-01-01

While the general class of most scheduling problems is NP-hard in worst-case complexity, in practice, for specific distributions of problems and constraints, domain-specific solutions have been shown to perform in much better than exponential time.

Availability Analysis of Dual Mode Systems

DOT National Transportation Integrated Search

1974-04-01

The analytical procedures presented define a method of evaluating the effects of failures in a complex dual-mode system based on a worst case steady-state analysis. The computed result is an availability figure of merit and not an absolute prediction...

Topical Backgrounder: Evaluating Chemical Hazards in the Community: Using RMP's Offsite Consequence Analysis

EPA Pesticide Factsheets

Part of a May 1999 series on the Risk Management Program Rule and issues related to chemical emergency management. Explains hazard versus risk, worst-case and alternative release scenarios, flammable endpoints and toxic endpoints.

General RMP Guidance - Chapter 4: Offsite Consequence Analysis

EPA Pesticide Factsheets

This chapter provides basic compliance information, not modeling methodologies, for people who plan to do their own air dispersion modeling. OCA is a required part of the risk management program, and involves worst-case and alternative release scenarios.

INCORPORATING NONCHEMICAL STRESSORS INTO CUMMULATIVE RISK ASSESSMENTS

EPA Science Inventory

The risk assessment paradigm has begun to shift from assessing single chemicals using "reasonable worst case" assumptions for individuals to considering multiple chemicals and community-based models. Inherent in community-based risk assessment is examination of all stressors a...

30 CFR 254.26 - What information must I include in the “Worst case discharge scenario” appendix?

Code of Federal Regulations, 2011 CFR

2011-07-01

... limits of current technology, for the range of environmental conditions anticipated at your facility; and... Society for Testing of Materials (ASTM) publication F625-94, Standard Practice for Describing...

30 CFR 254.26 - What information must I include in the “Worst case discharge scenario” appendix?

Code of Federal Regulations, 2010 CFR

2010-07-01

..., materials, support vessels, and strategies listed are suitable, within the limits of current technology, for... equipment. Examples of acceptable terms include those defined in American Society for Testing of Materials...

Characteristics of worst hour rainfall rate for radio wave propagation modelling in Nigeria

NASA Astrophysics Data System (ADS)

Osita, Ibe; Nymphas, E. F.

2017-10-01

Radio waves especially at the millimeter-wave band are known to be attenuated by rain. Radio engineers and designers need to be able to predict the time of the day when radio signal will be attenuated so as to provide measures to mitigate this effect. This is achieved by characterizing the rainfall intensity for a particular region of interest into worst month and worst hour of the day. This paper characterized rainfall in Nigeria into worst year, worst month, and worst hour. It is shown that for the period of study, 2008 and 2009 are the worst years, while September is the most frequent worst month in most of the stations. The evening time (LT) is the worst hours of the day in virtually all the stations.

Stressful life events and catechol-O-methyl-transferase (COMT) gene in bipolar disorder.

PubMed

Hosang, Georgina M; Fisher, Helen L; Cohen-Woods, Sarah; McGuffin, Peter; Farmer, Anne E

2017-05-01

A small body of research suggests that gene-environment interactions play an important role in the development of bipolar disorder. The aim of the present study is to contribute to this work by exploring the relationship between stressful life events and the catechol-O-methyl-transferase (COMT) Val 158 Met polymorphism in bipolar disorder. Four hundred eighty-two bipolar cases and 205 psychiatrically healthy controls completed the List of Threatening Experiences Questionnaire. Bipolar cases reported the events experienced 6 months before their worst depressive and manic episodes; controls reported those events experienced 6 months prior to their interview. The genotypic information for the COMT Val 158 Met variant (rs4680) was extracted from GWAS analysis of the sample. The impact of stressful life events was moderated by the COMT genotype for the worst depressive episode using a Val dominant model (adjusted risk difference = 0.09, 95% confidence intervals = 0.003-0.18, P = .04). For the worst manic episodes no significant interactions between COMT and stressful life events were detected. This is the first study to explore the relationship between stressful life events and the COMT Val 158 Met polymorphism focusing solely on bipolar disorder. The results of this study highlight the importance of the interplay between genetic and environmental factors for bipolar depression. © 2017 Wiley Periodicals, Inc.

Probability-of-success studies for geothermal projects: from subsurface data to geological risk analysis

NASA Astrophysics Data System (ADS)

Schumacher, Sandra; Pierau, Roberto; Wirth, Wolfgang

2017-04-01

In recent years, the development of geothermal plants in Germany has increased significantly due to a favorable political setting and resulting financial incentives. However, most projects are developed by local communities or private investors, which cannot afford a project to fail. To cover the risk of total loss if the geothermal well should not provide the energy output necessary for an economically viable project, investors try to procure insurances for this worst case scenario. In order to issue such insurances, the insurance companies insist on so called probability-of-success studies (POS studies), in which the geological risk for not achieving the necessary temperatures and/or flow rates for an economically successful project is quantified. Quantifying the probability of reaching a minimum temperature, which has to be defined by the project investors, is relatively straight forward as subsurface temperatures in Germany are comparatively well known due tens of thousands of hydrocarbon wells. Moreover, for the German Molasse Basin a method to characterize the hydraulic potential of a site based on pump test analysis has been developed and refined in recent years. However, to quantify the probability of reaching a given flow rate with a given drawdown is much more challenging in areas where pump test data are generally not available (e.g. the North German Basin). Therefore, a new method based on log and core derived porosity and permeability data was developed to quantify the geological risk of reaching a determined flow rate in such areas. We present both methods for POS studies and show how subsurface data such as pump tests or log and core measurements can be used to predict the chances of a potential geothermal project from a geological point of view.

"Just Let the Worst Students Go": A Critical Case Analysis of Public Discourse about Race, Merit, and Worth

ERIC Educational Resources Information Center

Zirkel, Sabrina; Pollack, Terry M.

2016-01-01

We present a case analysis of the controversy and public debate generated from a school district's efforts to address racial inequities in educational outcomes by diverting special funds from the highest performing students seeking elite college admissions to the lowest performing students who were struggling to graduate from high school.…

Beyond the Moscow Treaty: Alternative Perspectives on the Future Roles and Utility of Nuclear Weapons

DTIC Science & Technology

2008-03-01

Adversarial Tripolarity ................................................................................... VII-1 VIII. Fallen Nuclear Dominoes...power dimension, it is possible to imagine a best case (deep concert) and a worst case (adversarial tripolarity ) and some less extreme outcomes, one...vanquished and the sub-regions have settled into relative stability). 5. Adversarial U.S.-Russia-China tripolarity : In this world, the regional

The Best of Times and the Worst of Times: Research Managed as a Performance Economy--The Australian Case. ASHE Annual Meeting Paper.

ERIC Educational Resources Information Center

Marginson, Simon

This study examined the character of the emerging systems of corporate management in Australian universities and their effects on academic and administrative practices, focusing on relations of power. Case studies were conducted at 17 individual universities of various types. In each institution, interviews were conducted with senior…

Elementary Social Studies in 2005: Danger or Opportunity?--A Response to Jeff Passe

ERIC Educational Resources Information Center

Libresco, Andrea S.

2006-01-01

From the emphasis on lower-level test-prep materials to the disappearance of the subject altogether, elementary social studies is, in the best case scenario, being tested and, thus, taught with a heavy emphasis on recall; and, in the worst-case scenario, not being taught at all. In this article, the author responds to Jeff Passe's views on…

Thermal Analysis of a Metallic Wing Glove for a Mach-8 Boundary-Layer Experiment

NASA Technical Reports Server (NTRS)

Gong, Leslie; Richards, W. Lance

1998-01-01

A metallic 'glove' structure has been built and attached to the wing of the Pegasus(trademark) space booster. An experiment on the upper surface of the glove has been designed to help validate boundary-layer stability codes in a free-flight environment. Three-dimensional thermal analyses have been performed to ensure that the glove structure design would be within allowable temperature limits in the experiment test section of the upper skin of the glove. Temperature results obtained from the design-case analysis show a peak temperature at the leading edge of 490 F. For the upper surface of the glove, approximately 3 in. back from the leading edge, temperature calculations indicate transition occurs at approximately 45 sec into the flight profile. A worst-case heating analysis has also been performed to ensure that the glove structure would not have any detrimental effects on the primary objective of the Pegasus a launch. A peak temperature of 805 F has been calculated on the leading edge of the glove structure. The temperatures predicted from the design case are well within the temperature limits of the glove structure, and the worst-case heating analysis temperature results are acceptable for the mission objectives.

Extrapolating target tracks

NASA Astrophysics Data System (ADS)

Van Zandt, James R.

2012-05-01

Steady-state performance of a tracking filter is traditionally evaluated immediately after a track update. However, there is commonly a further delay (e.g., processing and communications latency) before the tracks can actually be used. We analyze the accuracy of extrapolated target tracks for four tracking filters: Kalman filter with the Singer maneuver model and worst-case correlation time, with piecewise constant white acceleration, and with continuous white acceleration, and the reduced state filter proposed by Mookerjee and Reifler.1, 2 Performance evaluation of a tracking filter is significantly simplified by appropriate normalization. For the Kalman filter with the Singer maneuver model, the steady-state RMS error immediately after an update depends on only two dimensionless parameters.3 By assuming a worst case value of target acceleration correlation time, we reduce this to a single parameter without significantly changing the filter performance (within a few percent for air tracking).4 With this simplification, we find for all four filters that the RMS errors for the extrapolated state are functions of only two dimensionless parameters. We provide simple analytic approximations in each case.

Comprehensive all-sky search for periodic gravitational waves in the sixth science run LIGO data

NASA Astrophysics Data System (ADS)

Abbott, B. P.; Abbott, R.; Abbott, T. D.; Abernathy, M. R.; Acernese, F.; Ackley, K.; Adams, C.; Adams, T.; Addesso, P.; Adhikari, R. X.; Adya, V. B.; Affeldt, C.; Agathos, M.; Agatsuma, K.; Aggarwal, N.; Aguiar, O. D.; Aiello, L.; Ain, A.; Ajith, P.; Allen, B.; Allocca, A.; Altin, P. A.; Anderson, S. B.; Anderson, W. G.; Arai, K.; Araya, M. C.; Arceneaux, C. C.; Areeda, J. S.; Arnaud, N.; Arun, K. G.; Ascenzi, S.; Ashton, G.; Ast, M.; Aston, S. M.; Astone, P.; Aufmuth, P.; Aulbert, C.; Babak, S.; Bacon, P.; Bader, M. K. M.; Baker, P. T.; Baldaccini, F.; Ballardin, G.; Ballmer, S. W.; Barayoga, J. C.; Barclay, S. E.; Barish, B. C.; Barker, D.; Barone, F.; Barr, B.; Barsotti, L.; Barsuglia, M.; Barta, D.; Bartlett, J.; Bartos, I.; Bassiri, R.; Basti, A.; Batch, J. C.; Baune, C.; Bavigadda, V.; Bazzan, M.; Bejger, M.; Bell, A. S.; Berger, B. K.; Bergmann, G.; Berry, C. P. L.; Bersanetti, D.; Bertolini, A.; Betzwieser, J.; Bhagwat, S.; Bhandare, R.; Bilenko, I. A.; Billingsley, G.; Birch, J.; Birney, R.; Biscans, S.; Bisht, A.; Bitossi, M.; Biwer, C.; Bizouard, M. A.; Blackburn, J. K.; Blair, C. D.; Blair, D. G.; Blair, R. M.; Bloemen, S.; Bock, O.; Boer, M.; Bogaert, G.; Bogan, C.; Bohe, A.; Bond, C.; Bondu, F.; Bonnand, R.; Boom, B. A.; Bork, R.; Boschi, V.; Bose, S.; Bouffanais, Y.; Bozzi, A.; Bradaschia, C.; Brady, P. R.; Braginsky, V. B.; Branchesi, M.; Brau, J. E.; Briant, T.; Brillet, A.; Brinkmann, M.; Brisson, V.; Brockill, P.; Broida, J. E.; Brooks, A. F.; Brown, D. A.; Brown, D. D.; Brown, N. M.; Brunett, S.; Buchanan, C. C.; Buikema, A.; Bulik, T.; Bulten, H. J.; Buonanno, A.; Buskulic, D.; Buy, C.; Byer, R. L.; Cabero, M.; Cadonati, L.; Cagnoli, G.; Cahillane, C.; Calderón Bustillo, J.; Callister, T.; Calloni, E.; Camp, J. B.; Cannon, K. C.; Cao, J.; Capano, C. D.; Capocasa, E.; Carbognani, F.; Caride, S.; Casanueva Diaz, J.; Casentini, C.; Caudill, S.; Cavaglià, M.; Cavalier, F.; Cavalieri, R.; Cella, G.; Cepeda, C. B.; Cerboni Baiardi, L.; Cerretani, G.; Cesarini, E.; Chan, M.; Chao, S.; Charlton, P.; Chassande-Mottin, E.; Cheeseboro, B. D.; Chen, H. Y.; Chen, Y.; Cheng, C.; Chincarini, A.; Chiummo, A.; Cho, H. S.; Cho, M.; Chow, J. H.; Christensen, N.; Chu, Q.; Chua, S.; Chung, S.; Ciani, G.; Clara, F.; Clark, J. A.; Cleva, F.; Coccia, E.; Cohadon, P.-F.; Colla, A.; Collette, C. G.; Cominsky, L.; Constancio, M.; Conte, A.; Conti, L.; Cook, D.; Corbitt, T. R.; Cornish, N.; Corsi, A.; Cortese, S.; Costa, C. A.; Coughlin, M. W.; Coughlin, S. B.; Coulon, J.-P.; Countryman, S. T.; Couvares, P.; Cowan, E. E.; Coward, D. M.; Cowart, M. J.; Coyne, D. C.; Coyne, R.; Craig, K.; Creighton, J. D. E.; Creighton, T.; Cripe, J.; Crowder, S. G.; Cumming, A.; Cunningham, L.; Cuoco, E.; Dal Canton, T.; Danilishin, S. L.; D'Antonio, S.; Danzmann, K.; Darman, N. S.; Dasgupta, A.; Da Silva Costa, C. F.; Dattilo, V.; Dave, I.; Davier, M.; Davies, G. S.; Daw, E. J.; Day, R.; De, S.; DeBra, D.; Debreczeni, G.; Degallaix, J.; De Laurentis, M.; Deléglise, S.; Del Pozzo, W.; Denker, T.; Dent, T.; Dergachev, V.; De Rosa, R.; DeRosa, R. T.; DeSalvo, R.; Devine, R. C.; Dhurandhar, S.; Díaz, M. C.; Di Fiore, L.; Di Giovanni, M.; Di Girolamo, T.; Di Lieto, A.; Di Pace, S.; Di Palma, I.; Di Virgilio, A.; Dolique, V.; Donovan, F.; Dooley, K. L.; Doravari, S.; Douglas, R.; Downes, T. P.; Drago, M.; Drever, R. W. P.; Driggers, J. C.; Ducrot, M.; Dwyer, S. E.; Edo, T. B.; Edwards, M. C.; Effler, A.; Eggenstein, H.-B.; Ehrens, P.; Eichholz, J.; Eikenberry, S. S.; Engels, W.; Essick, R. C.; Etzel, T.; Evans, M.; Evans, T. M.; Everett, R.; Factourovich, M.; Fafone, V.; Fair, H.; Fairhurst, S.; Fan, X.; Fang, Q.; Farinon, S.; Farr, B.; Farr, W. M.; Favata, M.; Fays, M.; Fehrmann, H.; Fejer, M. M.; Fenyvesi, E.; Ferrante, I.; Ferreira, E. C.; Ferrini, F.; Fidecaro, F.; Fiori, I.; Fiorucci, D.; Fisher, R. P.; Flaminio, R.; Fletcher, M.; Fournier, J.-D.; Frasca, S.; Frasconi, F.; Frei, Z.; Freise, A.; Frey, R.; Frey, V.; Fritschel, P.; Frolov, V. V.; Fulda, P.; Fyffe, M.; Gabbard, H. A. G.; Gair, J. R.; Gammaitoni, L.; Gaonkar, S. G.; Garufi, F.; Gaur, G.; Gehrels, N.; Gemme, G.; Geng, P.; Genin, E.; Gennai, A.; George, J.; Gergely, L.; Germain, V.; Ghosh, Abhirup; Ghosh, Archisman; Ghosh, S.; Giaime, J. A.; Giardina, K. D.; Giazotto, A.; Gill, K.; Glaefke, A.; Goetz, E.; Goetz, R.; Gondan, L.; González, G.; Gonzalez Castro, J. M.; Gopakumar, A.; Gordon, N. A.; Gorodetsky, M. L.; Gossan, S. E.; Gosselin, M.; Gouaty, R.; Grado, A.; Graef, C.; Graff, P. B.; Granata, M.; Grant, A.; Gras, S.; Gray, C.; Greco, G.; Green, A. C.; Groot, P.; Grote, H.; Grunewald, S.; Guidi, G. M.; Guo, X.; Gupta, A.; Gupta, M. K.; Gushwa, K. E.; Gustafson, E. K.; Gustafson, R.; Hacker, J. J.; Hall, B. R.; Hall, E. D.; Hammond, G.; Haney, M.; Hanke, M. M.; Hanks, J.; Hanna, C.; Hannam, M. D.; Hanson, J.; Hardwick, T.; Harms, J.; Harry, G. M.; Harry, I. W.; Hart, M. J.; Hartman, M. T.; Haster, C.-J.; Haughian, K.; Heidmann, A.; Heintze, M. C.; Heitmann, H.; Hello, P.; Hemming, G.; Hendry, M.; Heng, I. S.; Hennig, J.; Henry, J.; Heptonstall, A. W.; Heurs, M.; Hild, S.; Hoak, D.; Hofman, D.; Holt, K.; Holz, D. E.; Hopkins, P.; Hough, J.; Houston, E. A.; Howell, E. J.; Hu, Y. M.; Huang, S.; Huerta, E. A.; Huet, D.; Hughey, B.; Husa, S.; Huttner, S. H.; Huynh-Dinh, T.; Indik, N.; Ingram, D. R.; Inta, R.; Isa, H. N.; Isac, J.-M.; Isi, M.; Isogai, T.; Iyer, B. R.; Izumi, K.; Jacqmin, T.; Jang, H.; Jani, K.; Jaranowski, P.; Jawahar, S.; Jian, L.; Jiménez-Forteza, F.; Johnson, W. W.; Jones, D. I.; Jones, R.; Jonker, R. J. G.; Ju, L.; Haris, K.; Kalaghatgi, C. V.; Kalogera, V.; Kandhasamy, S.; Kang, G.; Kanner, J. B.; Kapadia, S. J.; Karki, S.; Karvinen, K. S.; Kasprzack, M.; Katsavounidis, E.; Katzman, W.; Kaufer, S.; Kaur, T.; Kawabe, K.; Kéfélian, F.; Kehl, M. S.; Keitel, D.; Kelley, D. B.; Kells, W.; Kennedy, R.; Key, J. S.; Khalili, F. Y.; Khan, I.; Khan, S.; Khan, Z.; Khazanov, E. A.; Kijbunchoo, N.; Kim, Chi-Woong; Kim, Chunglee; Kim, J.; Kim, K.; Kim, N.; Kim, W.; Kim, Y.-M.; Kimbrell, S. J.; King, E. J.; King, P. J.; Kissel, J. S.; Klein, B.; Kleybolte, L.; Klimenko, S.; Koehlenbeck, S. M.; Koley, S.; Kondrashov, V.; Kontos, A.; Korobko, M.; Korth, W. Z.; Kowalska, I.; Kozak, D. B.; Kringel, V.; Krishnan, B.; Królak, A.; Krueger, C.; Kuehn, G.; Kumar, P.; Kumar, R.; Kuo, L.; Kutynia, A.; Lackey, B. D.; Landry, M.; Lange, J.; Lantz, B.; Lasky, P. D.; Laxen, M.; Lazzarini, A.; Lazzaro, C.; Leaci, P.; Leavey, S.; Lebigot, E. O.; Lee, C. H.; Lee, H. K.; Lee, H. M.; Lee, K.; Lenon, A.; Leonardi, M.; Leong, J. R.; Leroy, N.; Letendre, N.; Levin, Y.; Lewis, J. B.; Li, T. G. F.; Libson, A.; Littenberg, T. B.; Lockerbie, N. A.; Lombardi, A. L.; London, L. T.; Lord, J. E.; Lorenzini, M.; Loriette, V.; Lormand, M.; Losurdo, G.; Lough, J. D.; Lück, H.; Lundgren, A. P.; Lynch, R.; Ma, Y.; Machenschalk, B.; MacInnis, M.; Macleod, D. M.; Magaña-Sandoval, F.; Magaña Zertuche, L.; Magee, R. M.; Majorana, E.; Maksimovic, I.; Malvezzi, V.; Man, N.; Mandel, I.; Mandic, V.; Mangano, V.; Mansell, G. L.; Manske, M.; Mantovani, M.; Marchesoni, F.; Marion, F.; Márka, S.; Márka, Z.; Markosyan, A. S.; Maros, E.; Martelli, F.; Martellini, L.; Martin, I. W.; Martynov, D. V.; Marx, J. N.; Mason, K.; Masserot, A.; Massinger, T. J.; Masso-Reid, M.; Mastrogiovanni, S.; Matichard, F.; Matone, L.; Mavalvala, N.; Mazumder, N.; McCarthy, R.; McClelland, D. E.; McCormick, S.; McGuire, S. C.; McIntyre, G.; McIver, J.; McManus, D. J.; McRae, T.; McWilliams, S. T.; Meacher, D.; Meadors, G. D.; Meidam, J.; Melatos, A.; Mendell, G.; Mercer, R. A.; Merilh, E. L.; Merzougui, M.; Meshkov, S.; Messenger, C.; Messick, C.; Metzdorff, R.; Meyers, P. M.; Mezzani, F.; Miao, H.; Michel, C.; Middleton, H.; Mikhailov, E. E.; Milano, L.; Miller, A. L.; Miller, A.; Miller, B. B.; Miller, J.; Millhouse, M.; Minenkov, Y.; Ming, J.; Mirshekari, S.; Mishra, C.; Mitra, S.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Moggi, A.; Mohan, M.; Mohapatra, S. R. P.; Montani, M.; Moore, B. C.; Moore, C. J.; Moraru, D.; Moreno, G.; Morriss, S. R.; Mossavi, K.; Mours, B.; Mow-Lowry, C. M.; Mueller, G.; Muir, A. W.; Mukherjee, Arunava; Mukherjee, D.; Mukherjee, S.; Mukund, N.; Mullavey, A.; Munch, J.; Murphy, D. J.; Murray, P. G.; Mytidis, A.; Nardecchia, I.; Naticchioni, L.; Nayak, R. K.; Nedkova, K.; Nelemans, G.; Nelson, T. J. N.; Neri, M.; Neunzert, A.; Newton, G.; Nguyen, T. T.; Nielsen, A. B.; Nissanke, S.; Nitz, A.; Nocera, F.; Nolting, D.; Normandin, M. E. N.; Nuttall, L. K.; Oberling, J.; Ochsner, E.; O'Dell, J.; Oelker, E.; Ogin, G. H.; Oh, J. J.; Oh, S. H.; Ohme, F.; Oliver, M.; Oppermann, P.; Oram, Richard J.; O'Reilly, B.; O'Shaughnessy, R.; Ottaway, D. J.; Overmier, H.; Owen, B. J.; Pai, A.; Pai, S. A.; Palamos, J. R.; Palashov, O.; Palomba, C.; Pal-Singh, A.; Pan, H.; Pankow, C.; Pannarale, F.; Pant, B. C.; Paoletti, F.; Paoli, A.; Papa, M. A.; Paris, H. R.; Parker, W.; Pascucci, D.; Pasqualetti, A.; Passaquieti, R.; Passuello, D.; Patricelli, B.; Patrick, Z.; Pearlstone, B. L.; Pedraza, M.; Pedurand, R.; Pekowsky, L.; Pele, A.; Penn, S.; Perreca, A.; Perri, L. M.; Phelps, M.; Piccinni, O. J.; Pichot, M.; Piergiovanni, F.; Pierro, V.; Pillant, G.; Pinard, L.; Pinto, I. M.; Pitkin, M.; Poe, M.; Poggiani, R.; Popolizio, P.; Post, A.; Powell, J.; Prasad, J.; Predoi, V.; Prestegard, T.; Price, L. R.; Prijatelj, M.; Principe, M.; Privitera, S.; Prix, R.; Prodi, G. A.; Prokhorov, L.; Puncken, O.; Punturo, M.; Puppo, P.; Pürrer, M.; Qi, H.; Qin, J.; Qiu, S.; Quetschke, V.; Quintero, E. A.; Quitzow-James, R.; Raab, F. J.; Rabeling, D. S.; Radkins, H.; Raffai, P.; Raja, S.; Rajan, C.; Rakhmanov, M.; Rapagnani, P.; Raymond, V.; Razzano, M.; Re, V.; Read, J.; Reed, C. M.; Regimbau, T.; Rei, L.; Reid, S.; Reitze, D. H.; Rew, H.; Reyes, S. D.; Ricci, F.; Riles, K.; Rizzo, M.; Robertson, N. A.; Robie, R.; Robinet, F.; Rocchi, A.; Rolland, L.; Rollins, J. G.; Roma, V. J.; Romano, J. D.; Romano, R.; Romanov, G.; Romie, J. H.; Rosińska, D.; Rowan, S.; Rüdiger, A.; Ruggi, P.; Ryan, K.; Sachdev, S.; Sadecki, T.; Sadeghian, L.; Sakellariadou, M.; Salconi, L.; Saleem, M.; Salemi, F.; Samajdar, A.; Sammut, L.; Sanchez, E. J.; Sandberg, V.; Sandeen, B.; Sanders, J. R.; Sassolas, B.; Sathyaprakash, B. S.; Saulson, P. R.; Sauter, O. E. S.; Savage, R. L.; Sawadsky, A.; Schale, P.; Schilling, R.; Schmidt, J.; Schmidt, P.; Schnabel, R.; Schofield, R. M. S.; Schönbeck, A.; Schreiber, E.; Schuette, D.; Schutz, B. F.; Scott, J.; Scott, S. M.; Sellers, D.; Sengupta, A. S.; Sentenac, D.; Sequino, V.; Sergeev, A.; Setyawati, Y.; Shaddock, D. A.; Shaffer, T.; Shahriar, M. S.; Shaltev, M.; Shapiro, B.; Shawhan, P.; Sheperd, A.; Shoemaker, D. H.; Shoemaker, D. M.; Siellez, K.; Siemens, X.; Sieniawska, M.; Sigg, D.; Silva, A. D.; Singer, A.; Singer, L. P.; Singh, A.; Singh, R.; Singhal, A.; Sintes, A. M.; Slagmolen, B. J. J.; Smith, J. R.; Smith, N. D.; Smith, R. J. E.; Son, E. J.; Sorazu, B.; Sorrentino, F.; Souradeep, T.; Srivastava, A. K.; Staley, A.; Steinke, M.; Steinlechner, J.; Steinlechner, S.; Steinmeyer, D.; Stephens, B. C.; Stone, R.; Strain, K. A.; Straniero, N.; Stratta, G.; Strauss, N. A.; Strigin, S.; Sturani, R.; Stuver, A. L.; Summerscales, T. Z.; Sun, L.; Sunil, S.; Sutton, P. J.; Swinkels, B. L.; Szczepańczyk, M. J.; Tacca, M.; Talukder, D.; Tanner, D. B.; Tápai, M.; Tarabrin, S. P.; Taracchini, A.; Taylor, R.; Theeg, T.; Thirugnanasambandam, M. P.; Thomas, E. G.; Thomas, M.; Thomas, P.; Thorne, K. A.; Thrane, E.; Tiwari, S.; Tiwari, V.; Tokmakov, K. V.; Toland, K.; Tomlinson, C.; Tonelli, M.; Tornasi, Z.; Torres, C. V.; Torrie, C. I.; Töyrä, D.; Travasso, F.; Traylor, G.; Trifirò, D.; Tringali, M. C.; Trozzo, L.; Tse, M.; Turconi, M.; Tuyenbayev, D.; Ugolini, D.; Unnikrishnan, C. S.; Urban, A. L.; Usman, S. A.; Vahlbruch, H.; Vajente, G.; Valdes, G.; van Bakel, N.; van Beuzekom, M.; van den Brand, J. F. J.; Van Den Broeck, C.; Vander-Hyde, D. C.; van der Schaaf, L.; van Heijningen, J. V.; van Veggel, A. A.; Vardaro, M.; Vass, S.; Vasúth, M.; Vaulin, R.; Vecchio, A.; Vedovato, G.; Veitch, J.; Veitch, P. J.; Venkateswara, K.; Verkindt, D.; Vetrano, F.; Viceré, A.; Vinciguerra, S.; Vine, D. J.; Vinet, J.-Y.; Vitale, S.; Vo, T.; Vocca, H.; Vorvick, C.; Voss, D. V.; Vousden, W. D.; Vyatchanin, S. P.; Wade, A. R.; Wade, L. E.; Wade, M.; Walker, M.; Wallace, L.; Walsh, S.; Wang, G.; Wang, H.; Wang, M.; Wang, X.; Wang, Y.; Ward, R. L.; Warner, J.; Was, M.; Weaver, B.; Wei, L.-W.; Weinert, M.; Weinstein, A. J.; Weiss, R.; Wen, L.; Weßels, P.; Westphal, T.; Wette, K.; Whelan, J. T.; Whiting, B. F.; Williams, R. D.; Williamson, A. R.; Willis, J. L.; Willke, B.; Wimmer, M. H.; Winkler, W.; Wipf, C. C.; Wittel, H.; Woan, G.; Woehler, J.; Worden, J.; Wright, J. L.; Wu, D. S.; Wu, G.; Yablon, J.; Yam, W.; Yamamoto, H.; Yancey, C. C.; Yu, H.; Yvert, M.; ZadroŻny, A.; Zangrando, L.; Zanolin, M.; Zendri, J.-P.; Zevin, M.; Zhang, L.; Zhang, M.; Zhang, Y.; Zhao, C.; Zhou, M.; Zhou, Z.; Zhu, X. J.; Zucker, M. E.; Zuraw, S. E.; Zweizig, J.; LIGO Scientific Collaboration; Virgo Collaboration

2016-08-01

We report on a comprehensive all-sky search for periodic gravitational waves in the frequency band 100-1500 Hz and with a frequency time derivative in the range of [-1.18 ,+1.00 ] ×1 0-8 Hz /s . Such a signal could be produced by a nearby spinning and slightly nonaxisymmetric isolated neutron star in our galaxy. This search uses the data from the initial LIGO sixth science run and covers a larger parameter space with respect to any past search. A Loosely Coherent detection pipeline was applied to follow up weak outliers in both Gaussian (95% recovery rate) and non-Gaussian (75% recovery rate) bands. No gravitational wave signals were observed, and upper limits were placed on their strength. Our smallest upper limit on worst-case (linearly polarized) strain amplitude h0 is 9.7 ×1 0-25 near 169 Hz, while at the high end of our frequency range we achieve a worst-case upper limit of 5.5 ×1 0-24 . Both cases refer to all sky locations and entire range of frequency derivative values.

Zika virus in French Polynesia 2013-14: anatomy of a completed outbreak.

PubMed

Musso, Didier; Bossin, Hervé; Mallet, Henri Pierre; Besnard, Marianne; Broult, Julien; Baudouin, Laure; Levi, José Eduardo; Sabino, Ester C; Ghawche, Frederic; Lanteri, Marion C; Baud, David

2018-05-01

The Zika virus crisis exemplified the risk associated with emerging pathogens and was a reminder that preparedness for the worst-case scenario, although challenging, is needed. Herein, we review all data reported during the unexpected emergence of Zika virus in French Polynesia in late 2013. We focus on the new findings reported during this outbreak, especially the first description of severe neurological complications in adults and the retrospective description of CNS malformations in neonates, the isolation of Zika virus in semen, the potential for blood-transfusion transmission, mother-to-child transmission, and the development of new diagnostic assays. We describe the effect of this outbreak on health systems, the implementation of vector-borne control strategies, and the line of communication used to alert the international community of the new risk associated with Zika virus. This outbreak highlighted the need for careful monitoring of all unexpected events that occur during an emergence, to implement surveillance and research programmes in parallel to management of cases, and to be prepared to the worst-case scenario. Copyright © 2018 Elsevier Ltd. All rights reserved.

Are we producing PHAs? On the target selection for a proposed mitigation demo-mission within the NEO-Shield project

NASA Astrophysics Data System (ADS)

Eggl, S.; Hestroffer, D.; Thuillot, W.

2013-09-01

The Chelyabinsk event on February 15th, 2013 has shown once again that even small near earth objects (NEOs) can become a real safety concern. Eventhough we believe to have the capabilities to avert larger potentially disastrous asteroid impacts, only the realization of mitigation demonstration missions can confirm this claim. The target selection process for such deflection demonstrations is a demanding task, as physical, dynamical and engineering aspects have to be considered in great detail. One of the top priorities of such a demonstration mission is, of course, that a harmless asteroid should not be turned into a potentially hazardous object (PHO). Given the potentially large uncertainties in the asteroid's physical parameters as well as the additional uncertainties introduced during the deflection attempt, an in depth analysis of the impact probabilities over the next century becomes necessary, in order to exclude an augmentation of potential risks. Assuming worst case scenarios regard- ing the orbital, physical and mitigation induced uncertainties, we provide a keyhole and impact risk analysis of a list of potential targets for the mitigation demomission proposed in the framework of the NEO-Shield project.

Wear-Out Sensitivity Analysis Project Abstract

NASA Technical Reports Server (NTRS)

Harris, Adam

2015-01-01

During the course of the Summer 2015 internship session, I worked in the Reliability and Maintainability group of the ISS Safety and Mission Assurance department. My project was a statistical analysis of how sensitive ORU's (Orbital Replacement Units) are to a reliability parameter called the wear-out characteristic. The intended goal of this was to determine a worst case scenario of how many spares would be needed if multiple systems started exhibiting wear-out characteristics simultaneously. The goal was also to determine which parts would be most likely to do so. In order to do this, my duties were to take historical data of operational times and failure times of these ORU's and use them to build predictive models of failure using probability distribution functions, mainly the Weibull distribution. Then, I ran Monte Carlo Simulations to see how an entire population of these components would perform. From here, my final duty was to vary the wear-out characteristic from the intrinsic value, to extremely high wear-out values and determine how much the probability of sufficiency of the population would shift. This was done for around 30 different ORU populations on board the ISS.

Probability Quantization for Multiplication-Free Binary Arithmetic Coding

NASA Technical Reports Server (NTRS)

Cheung, K. -M.

1995-01-01

A method has been developed to improve on Witten's binary arithmetic coding procedure of tracking a high value and a low value. The new method approximates the probability of the less probable symbol, which improves the worst-case coding efficiency.

Carbon monoxide screen for signalized intersections : COSIM, version 4.0 - technical documentation.

DOT National Transportation Integrated Search

2013-06-01

Illinois Carbon Monoxide Screen for Intersection Modeling (COSIM) Version 3.0 is a Windows-based computer : program currently used by the Illinois Department of Transportation (IDOT) to estimate worst-case carbon : monoxide (CO) concentrations near s...

Global climate change: The quantifiable sustainability challenge

EPA Science Inventory

Population growth and the pressures spawned by increasing demands for energy and resource-intensive goods, foods and services are driving unsustainable growth in greenhouse gas (GHG) emissions. Recent GHG emission trends are consistent with worst-case scenarios of the previous de...

Potential health gains and health losses in eleven EU countries attainable through feasible prevalences of the life-style related risk factors alcohol, BMI, and smoking: a quantitative health impact assessment.

PubMed

Lhachimi, Stefan K; Nusselder, Wilma J; Smit, Henriette A; Baili, Paolo; Bennett, Kathleen; Fernández, Esteve; Kulik, Margarete C; Lobstein, Tim; Pomerleau, Joceline; Boshuizen, Hendriek C; Mackenbach, Johan P

2016-08-05

Influencing the life-style risk-factors alcohol, body mass index (BMI), and smoking is an European Union (EU) wide objective of public health policy. The population-level health effects of these risk-factors depend on population specific characteristics and are difficult to quantify without dynamic population health models. For eleven countries-approx. 80 % of the EU-27 population-we used evidence from the publicly available DYNAMO-HIA data-set. For each country the age- and sex-specific risk-factor prevalence and the incidence, prevalence, and excess mortality of nine chronic diseases are utilized; including the corresponding relative risks linking risk-factor exposure causally to disease incidence and all-cause mortality. Applying the DYNAMO-HIA tool, we dynamically project the country-wise potential health gains and losses using feasible, i.e. observed elsewhere, risk-factor prevalence rates as benchmarks. The effects of the "worst practice", "best practice", and the currently observed risk-factor prevalence on population health are quantified and expected changes in life expectancy, morbidity-free life years, disease cases, and cumulative mortality are reported. Applying the best practice smoking prevalence yields the largest gains in life expectancy with 0.4 years for males and 0.3 year for females (approx. 332,950 and 274,200 deaths postponed, respectively) while the worst practice smoking prevalence also leads to the largest losses with 0.7 years for males and 0.9 year for females (approx. 609,400 and 710,550 lives lost, respectively). Comparing morbidity-free life years, the best practice smoking prevalence shows the highest gains for males with 0.4 years (342,800 less disease cases), whereas for females the best practice BMI prevalence yields the largest gains with 0.7 years (1,075,200 less disease cases). Smoking is still the risk-factor with the largest potential health gains. BMI, however, has comparatively large effects on morbidity. Future research should aim to improve knowledge of how policies can influence and shape individual and aggregated life-style-related risk-factor behavior.

Accident epidemiology and the U.S. chemical industry: accident history and worst-case data from RMP*Info.

PubMed

Kleindorfer, Paul R; Belke, James C; Elliott, Michael R; Lee, Kiwan; Lowe, Robert A; Feldman, Harold I

2003-10-01

This article reports on the data collected on one of the most ambitious government-sponsored environmental data acquisition projects of all time, the Risk Management Plan (RMP) data collected under section 112(r) of the Clean Air Act Amendments of 1990. This RMP Rule 112(r) was triggered by the Bhopal accident in 1984 and led to the requirement that each qualifying facility develop and file with the U.S. Environmental Protection Agency a Risk Management Plan (RMP) as well as accident history data for the five-year period preceding the filing of the RMP. These data were collected in 1999-2001 on more than 15,000 facilities in the United States that store or use listed toxic or flammable chemicals believed to be a hazard to the environment or to human health of facility employees or off-site residents of host communities. The resulting database, RMP*Info, has become a key resource for regulators and researchers concerned with the frequency and severity of accidents, and the underlying facility-specific factors that are statistically associated with accident and injury rates. This article analyzes which facilities actually filed under the Rule and presents results on accident frequencies and severities available from the RMP*Info database. This article also presents summaries of related results from RMP*Info on Offsite Consequence Analysis (OCA), an analytical estimate of the potential consequences of hypothetical worst-case and alternative accidental releases on the public and environment around the facility. The OCA data have become a key input in the evaluation of site security assessment and mitigation policies for both government planners as well as facility managers and their insurers. Following the survey of the RMP*Info data, we discuss the rich set of policy decisions that may be informed by research based on these data.

Programmable Logic Application Notes

NASA Technical Reports Server (NTRS)

Katz, Richard

2000-01-01

This column will be provided each quarter as a source for reliability, radiation results, NASA capabilities, and other information on programmable logic devices and related applications. This quarter will start a series of notes concentrating on analysis techniques with this issues section discussing worst-case analysis requirements.

Alien invasive birds.

PubMed

Brochier, B; Vangeluwe, D; van den Berg, T

2010-08-01

A bird species is regarded as alien invasive if it has been introduced, intentionally or accidentally, to a location where it did not previously occur naturally, becomes capable of establishing a breeding population without further intervention by humans, spreads and becomes a pest affecting the environment, the local biodiversity, the economy and/or society, including human health. European Starling (Sturnus vulgaris), Common Myna (Acridotheres tristis) and Red-vented Bulbul (Pycnonotus cafer) have been included on the list of '100 of the World's Worst Invasive Alien Species', a subset of the Global Invasive Species Database. The 'Delivering Alien Invasive Species Inventories for Europe' project has selected Canada Goose (Branta canadensis), Ruddy Duck (Oxyura jamaicensis), Rose-ringed Parakeet (Psittacula krameri) and Sacred Ibis (Threskiornis aethiopicus) as among 100 of the worst invasive species in Europe. For each of these alien bird species, the geographic range (native and introduced range), the introduction pathway, the general impacts and the management methods are presented.

Selective robust optimization: A new intensity-modulated proton therapy optimization strategy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Yupeng; Niemela, Perttu; Siljamaki, Sami

2015-08-15

Purpose: To develop a new robust optimization strategy for intensity-modulated proton therapy as an important step in translating robust proton treatment planning from research to clinical applications. Methods: In selective robust optimization, a worst-case-based robust optimization algorithm is extended, and terms of the objective function are selectively computed from either the worst-case dose or the nominal dose. Two lung cancer cases and one head and neck cancer case were used to demonstrate the practical significance of the proposed robust planning strategy. The lung cancer cases had minimal tumor motion less than 5 mm, and, for the demonstration of the methodology,more » are assumed to be static. Results: Selective robust optimization achieved robust clinical target volume (CTV) coverage and at the same time increased nominal planning target volume coverage to 95.8%, compared to the 84.6% coverage achieved with CTV-based robust optimization in one of the lung cases. In the other lung case, the maximum dose in selective robust optimization was lowered from a dose of 131.3% in the CTV-based robust optimization to 113.6%. Selective robust optimization provided robust CTV coverage in the head and neck case, and at the same time improved controls over isodose distribution so that clinical requirements may be readily met. Conclusions: Selective robust optimization may provide the flexibility and capability necessary for meeting various clinical requirements in addition to achieving the required plan robustness in practical proton treatment planning settings.« less

A framework for multi-stakeholder decision-making and ...

EPA Pesticide Factsheets

We propose a decision-making framework to compute compromise solutions that balance conflicting priorities of multiple stakeholders on multiple objectives. In our setting, we shape the stakeholder dis-satisfaction distribution by solving a conditional-value-at-risk (CVaR) minimization problem. The CVaR problem is parameterized by a probability level that shapes the tail of the dissatisfaction distribution. The proposed approach allows us to compute a family of compromise solutions and generalizes multi-stakeholder settings previously proposed in the literature that minimize average and worst-case dissatisfactions. We use the concept of the CVaR norm to give a geometric interpretation to this problem +and use the properties of this norm to prove that the CVaR minimization problem yields Pareto optimal solutions for any choice of the probability level. We discuss a broad range of potential applications of the framework that involve complex decision-making processes. We demonstrate the developments using a biowaste facility location case study in which we seek to balance stakeholder priorities on transportation, safety, water quality, and capital costs. This manuscript describes the methodology of a new decision-making framework that computes compromise solutions that balance conflicting priorities of multiple stakeholders on multiple objectives as needed for SHC Decision Science and Support Tools project. A biowaste facility location is employed as the case study

Analysis of Separation Corridors for Visiting Vehicles from the International Space Station

NASA Technical Reports Server (NTRS)

Zaczek, Mariusz P.; Schrock, Rita R.; Schrock, Mark B.; Lowman, Bryan C.

2011-01-01

The International Space Station (ISS) is a very dynamic vehicle with many operational constraints that affect its performance, operations, and vehicle lifetime. Most constraints are designed to alleviate various safety concerns that are a result of dynamic activities between the ISS and various Visiting Vehicles (VVs). One such constraint that has been in place for Russian Vehicle (RV) operations is the limitation placed on Solar Array (SA) positioning in order to prevent collisions during separation and subsequent relative motion of VVs. An unintended consequence of the SA constraint has been the impacts to the operational flexibility of the ISS resulting from the reduced power generation capability as well as from a reduction in the operational lifetime of various SA components. The purpose of this paper is to discuss the technique and the analysis that were applied in order to relax the SA constraints for RV undockings, thereby improving both the ISS operational flexibility and extending its lifetime for many years to come. This analysis focused on the effects of the dynamic motion that occur both prior to and following RV separations. The analysis involved a parametric approach in the conservative application of various initial conditions and assumptions. These included the use of the worst case minimum and maximum vehicle configurations, worst case initial attitudes and attitude rates, and the worst case docking port separation dynamics. Separations were calculated for multiple ISS docking ports, at varied deviations from the nominal undocking attitudes and included the use of two separate attitude control schemes: continuous free-drift and a post separation attitude hold. The analysis required numerical propagation of both the separation motion and the vehicle attitudes using 3-degree-of-freedom (DOF) relative motion equations coupled with rigid body rotational dynamics to generate a large set of separation trajectories.

A structured framework for assessing sensitivity to missing data assumptions in longitudinal clinical trials.

PubMed

Mallinckrodt, C H; Lin, Q; Molenberghs, M

2013-01-01

The objective of this research was to demonstrate a framework for drawing inference from sensitivity analyses of incomplete longitudinal clinical trial data via a re-analysis of data from a confirmatory clinical trial in depression. A likelihood-based approach that assumed missing at random (MAR) was the primary analysis. Robustness to departure from MAR was assessed by comparing the primary result to those from a series of analyses that employed varying missing not at random (MNAR) assumptions (selection models, pattern mixture models and shared parameter models) and to MAR methods that used inclusive models. The key sensitivity analysis used multiple imputation assuming that after dropout the trajectory of drug-treated patients was that of placebo treated patients with a similar outcome history (placebo multiple imputation). This result was used as the worst reasonable case to define the lower limit of plausible values for the treatment contrast. The endpoint contrast from the primary analysis was - 2.79 (p = .013). In placebo multiple imputation, the result was - 2.17. Results from the other sensitivity analyses ranged from - 2.21 to - 3.87 and were symmetrically distributed around the primary result. Hence, no clear evidence of bias from missing not at random data was found. In the worst reasonable case scenario, the treatment effect was 80% of the magnitude of the primary result. Therefore, it was concluded that a treatment effect existed. The structured sensitivity framework of using a worst reasonable case result based on a controlled imputation approach with transparent and debatable assumptions supplemented a series of plausible alternative models under varying assumptions was useful in this specific situation and holds promise as a generally useful framework. Copyright © 2012 John Wiley & Sons, Ltd.

Ecological risk estimation of organophosphorus pesticides in riverine ecosystems.

PubMed

Wee, Sze Yee; Aris, Ahmad Zaharin

2017-12-01

Pesticides are of great concern because of their existence in ecosystems at trace concentrations. Worldwide pesticide use and its ecological impacts (i.e., altered environmental distribution and toxicity of pesticides) have increased over time. Exposure and toxicity studies are vital for reducing the extent of pesticide exposure and risk to the environment and humans. Regional regulatory actions may be less relevant in some regions because the contamination and distribution of pesticides vary across regions and countries. The risk quotient (RQ) method was applied to assess the potential risk of organophosphorus pesticides (OPPs), primarily focusing on riverine ecosystems. Using the available ecotoxicity data, aquatic risks from OPPs (diazinon and chlorpyrifos) in the surface water of the Langat River, Selangor, Malaysia were evaluated based on general (RQ m ) and worst-case (RQ ex ) scenarios. Since the ecotoxicity of quinalphos has not been well established, quinalphos was excluded from the risk assessment. The calculated RQs indicate medium risk (RQ m  = 0.17 and RQ ex  = 0.66; 0.1 ≤ RQ < 1) of overall diazinon. The overall chlorpyrifos exposure was observed at high risk (RQ ≥ 1) based on RQ m and RQ ex at 1.44 and 4.83, respectively. A contradictory trend of RQs > 1 (high risk) was observed for both the general and worst cases of chlorpyrifos, but only for the worst cases of diazinon at all sites from downstream to upstream regions. Thus, chlorpyrifos posed a higher risk than diazinon along the Langat River, suggesting that organisms and humans could be exposed to potentially high levels of OPPs. Copyright © 2017 Elsevier Ltd. All rights reserved.

Reducing the worst case running times of a family of RNA and CFG problems, using Valiant's approach.

PubMed

Zakov, Shay; Tsur, Dekel; Ziv-Ukelson, Michal

2011-08-18

RNA secondary structure prediction is a mainstream bioinformatic domain, and is key to computational analysis of functional RNA. In more than 30 years, much research has been devoted to defining different variants of RNA structure prediction problems, and to developing techniques for improving prediction quality. Nevertheless, most of the algorithms in this field follow a similar dynamic programming approach as that presented by Nussinov and Jacobson in the late 70's, which typically yields cubic worst case running time algorithms. Recently, some algorithmic approaches were applied to improve the complexity of these algorithms, motivated by new discoveries in the RNA domain and by the need to efficiently analyze the increasing amount of accumulated genome-wide data. We study Valiant's classical algorithm for Context Free Grammar recognition in sub-cubic time, and extract features that are common to problems on which Valiant's approach can be applied. Based on this, we describe several problem templates, and formulate generic algorithms that use Valiant's technique and can be applied to all problems which abide by these templates, including many problems within the world of RNA Secondary Structures and Context Free Grammars. The algorithms presented in this paper improve the theoretical asymptotic worst case running time bounds for a large family of important problems. It is also possible that the suggested techniques could be applied to yield a practical speedup for these problems. For some of the problems (such as computing the RNA partition function and base-pair binding probabilities), the presented techniques are the only ones which are currently known for reducing the asymptotic running time bounds of the standard algorithms.

Reducing the worst case running times of a family of RNA and CFG problems, using Valiant's approach

PubMed Central

2011-01-01

Background RNA secondary structure prediction is a mainstream bioinformatic domain, and is key to computational analysis of functional RNA. In more than 30 years, much research has been devoted to defining different variants of RNA structure prediction problems, and to developing techniques for improving prediction quality. Nevertheless, most of the algorithms in this field follow a similar dynamic programming approach as that presented by Nussinov and Jacobson in the late 70's, which typically yields cubic worst case running time algorithms. Recently, some algorithmic approaches were applied to improve the complexity of these algorithms, motivated by new discoveries in the RNA domain and by the need to efficiently analyze the increasing amount of accumulated genome-wide data. Results We study Valiant's classical algorithm for Context Free Grammar recognition in sub-cubic time, and extract features that are common to problems on which Valiant's approach can be applied. Based on this, we describe several problem templates, and formulate generic algorithms that use Valiant's technique and can be applied to all problems which abide by these templates, including many problems within the world of RNA Secondary Structures and Context Free Grammars. Conclusions The algorithms presented in this paper improve the theoretical asymptotic worst case running time bounds for a large family of important problems. It is also possible that the suggested techniques could be applied to yield a practical speedup for these problems. For some of the problems (such as computing the RNA partition function and base-pair binding probabilities), the presented techniques are the only ones which are currently known for reducing the asymptotic running time bounds of the standard algorithms. PMID:21851589

Indoor exposure to toluene from printed matter matters: complementary views from life cycle assessment and risk assessment.

PubMed

Walser, Tobias; Juraske, Ronnie; Demou, Evangelia; Hellweg, Stefanie

2014-01-01

A pronounced presence of toluene from rotogravure printed matter has been frequently observed indoors. However, its consequences to human health in the life cycle of magazines are poorly known. Therefore, we quantified human-health risks in indoor environments with Risk Assessment (RA) and impacts relative to the total impact of toxic releases occurring in the life cycle of a magazine with Life Cycle Assessment (LCA). We used a one-box indoor model to estimate toluene concentrations in printing facilities, newsstands, and residences in a best, average, and worst-case scenario. The modeled concentrations are in the range of the values measured in on-site campaigns. Toluene concentrations can be close or even surpass the occupational legal thresholds in printing facilities in realistic worst-case scenarios. The concentrations in homes can surpass the US EPA reference dose (69 μg/kg/day) in worst-case scenarios, but are still at least 1 order of magnitude lower than in press rooms or newsstands. However, toluene inhaled at home becomes the dominant contribution to the total potential human toxicity impacts of toluene from printed matter when assessed with LCA, using the USEtox method complemented with indoor characterization factors for toluene. The significant contribution (44%) of toluene exposure in production, retail, and use in households, to the total life cycle impact of a magazine in the category of human toxicity, demonstrates that the indoor compartment requires particular attention in LCA. While RA works with threshold levels, LCA assumes that every toxic emission causes an incremental change to the total impact. Here, the combination of the two paradigms provides valuable information on the life cycle stages of printed matter.

Level II scour analysis for Bridge 21 (MIDBTH00230021) on Town Highway 23, crossing the Middlebury River, Middlebury, Vermont

USGS Publications Warehouse

Boehmler, Erick M.; Degnan, James R.

1997-01-01

year discharges. In addition, the incipient roadway-overtopping discharge is determined and analyzed as another potential worst-case scour scenario. Total scour at a highway crossing is comprised of three components: 1) long-term streambed degradation; 2) contraction scour (due to accelerated flow caused by a reduction in flow area at a bridge) and; 3) local scour (caused by accelerated flow around piers and abutments). Total scour is the sum of the three components. Equations are available to compute depths for contraction and local scour and a summary of the results of these computations follows. Contraction scour for all modelled flows ranged from 1.2 to 1.8 feet. The worst-case contraction scour occurred at the incipient overtopping discharge, which is less than the 500-year discharge. Abutment scour ranged from 17.7 to 23.7 feet. The worst-case abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Economic losses to buildings due to tsunami impact: the case of Rhodes city, Greece

NASA Astrophysics Data System (ADS)

Triantafyllou, Ioanna; Novikova, Tatyana; Papadopoulos, Gerassimos

2017-04-01

The expected economic losses to buildings due to the tsunami impact is of particular importance for the tsunami risk management. However, only few efforts can be found in this direction. In this study we approached this issue selecting the city of Rhodes Isl., Greece, as a test-site. The methodological steps followed include (a) selection of worst case scenario in the study area based on the tsunami history of the area which includes several powerful events, e.g. 142 AD, 1303, 1481, 1609, 1741, (b) numerical simulation of the tsunami and determination of the inundation zone, (c) application of the DAMASCHE empirical tool, produced by the SCHEMA EU-FP6 project, for the calculation of the damage level expected at each one of the buildings as a function of the water depth in the inundation area, (d) calculation of the buildings that would need reparation after partial damage and of those that would need reconstruction after total destruction, (e) calculation of the cost implied for both reparation and reconstruction. The several data sets which are needed for the execution of these steps, are susceptible to uncertainties and, therefore, the final results are quite sensitive to changes of the data sets. Alternative costs were calculated by taking into account the several uncertainties involved. This research is a contribution to the EU-FP7 tsunami research project ASTARTE (Assessment, Strategy And Risk Reduction for Tsunamis in Europe), grant agreement no: 603839, 2013-10-30.

Poison ivy - oak - sumac rash

MedlinePlus

... reaction can vary from mild to severe. In rare cases, the person with the rash needs to be treated in the hospital. The worst symptoms are often seen during days 4 to 7 after coming in contact with the plant. The rash may last for 1 to 3 ...

Closed Environment Module - Modularization and extension of the Virtual Habitat

NASA Astrophysics Data System (ADS)

Plötner, Peter; Czupalla, Markus; Zhukov, Anton

2013-12-01

The Virtual Habitat (V-HAB), is a Life Support System (LSS) simulation, created to perform dynamic simulation of LSS's for future human spaceflight missions. It allows the testing of LSS robustness by means of computer simulations, e.g. of worst case scenarios.

49 CFR 238.431 - Brake system.

Code of Federal Regulations, 2011 CFR

2011-10-01

... train is operating under worst-case adhesion conditions. (b) The brake system shall be designed to allow... a brake rate consistent with prevailing adhesion, passenger safety, and brake system thermal... adhesion control system designed to automatically adjust the braking force on each wheel to prevent sliding...

40 CFR 300.135 - Response operations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION CONTINGENCY... discharge is a worst case discharge as discussed in § 300.324; the pathways to human and environmental exposure; the potential impact on human health, welfare, and safety and the environment; whether the...

Management of reliability and maintainability; a disciplined approach to fleet readiness

NASA Technical Reports Server (NTRS)

Willoughby, W. J., Jr.

1981-01-01

Material acquisition fundamentals were reviewed and include: mission profile definition, stress analysis, derating criteria, circuit reliability, failure modes, and worst case analysis. Military system reliability was examined with emphasis on the sparing of equipment. The Navy's organizational strategy for 1980 is presented.

Empirical Modeling Of Single-Event Upset

NASA Technical Reports Server (NTRS)

Zoutendyk, John A.; Smith, Lawrence S.; Soli, George A.; Thieberger, Peter; Smith, Stephen L.; Atwood, Gregory E.

1988-01-01

Experimental study presents examples of empirical modeling of single-event upset in negatively-doped-source/drain metal-oxide-semiconductor static random-access memory cells. Data supports adoption of simplified worst-case model in which cross sectionof SEU by ion above threshold energy equals area of memory cell.

A General Safety Assessment for Purified Food Ingredients Derived From Biotechnology Crops: Case Study of Brazilian Sugar and Beverages Produced From Insect-Protected Sugarcane.

PubMed

Kennedy, Reese D; Cheavegatti-Gianotto, Adriana; de Oliveira, Wladecir S; Lirette, Ronald P; Hjelle, Jerry J

2018-01-01

Insect-protected sugarcane that expresses Cry1Ab has been developed in Brazil. Analysis of trade information has shown that effectively all the sugarcane-derived Brazilian exports are raw or refined sugar and ethanol. The fact that raw and refined sugar are highly purified food ingredients, with no detectable transgenic protein, provides an interesting case study of a generalized safety assessment approach. In this study, both the theoretical protein intakes and safety assessments of Cry1Ab, Cry1Ac, NPTII, and Bar proteins used in insect-protected biotechnology crops were examined. The potential consumption of these proteins was examined using local market research data of average added sugar intakes in eight diverse and representative Brazilian raw and refined sugar export markets (Brazil, Canada, China, Indonesia, India, Japan, Russia, and the USA). The average sugar intakes, which ranged from 5.1 g of added sugar/person/day (India) to 126 g sugar/p/day (USA) were used to calculated possible human exposure. The theoretical protein intake estimates were carried out in the "Worst-case" scenario, assumed that 1 μg of newly-expressed protein is detected/g of raw or refined sugar; and the "Reasonable-case" scenario assumed 1 ng protein/g sugar. The "Worst-case" scenario was based on results of detailed studies of sugarcane processing in Brazil that showed that refined sugar contains less than 1 μg of total plant protein /g refined sugar. The "Reasonable-case" scenario was based on assumption that the expression levels in stalk of newly-expressed proteins were less than 0.1% of total stalk protein. Using these calculated protein intake values from the consumption of sugar, along with the accepted NOAEL levels of the four representative proteins we concluded that safety margins for the "Worst-case" scenario ranged from 6.9 × 10 5 to 5.9 × 10 7 and for the "Reasonable-case" scenario ranged from 6.9 × 10 8 to 5.9 × 10 10 . These safety margins are very high due to the extremely low possible exposures and the high NOAELs for these non-toxic proteins. This generalized approach to the safety assessment of highly purified food ingredients like sugar illustrates that sugar processed from Brazilian GM varieties are safe for consumption in representative markets globally.

Vapor Hydrogen Peroxide as Alternative to Dry Heat Microbial Reduction

NASA Technical Reports Server (NTRS)

Cash, Howard A.; Kern, Roger G.; Chung, Shirley Y.; Koukol, Robert C.; Barengoltz, Jack B.

2006-01-01

The Jet Propulsion Laboratory, in conjunction with the NASA Planetary Protection Officer, has selected vapor phase hydrogen peroxide (VHP) sterilization process for continued development as a NASA approved sterilization technique for spacecraft subsystems and systems. The goal is to include this technique, with appropriate specification, in NPG8020.12C as a low temperature complementary technique to the dry heat sterilization process. A series of experiments were conducted in vacuum to determine VHP process parameters that provided significant reductions in spore viability while allowing survival of sufficient spores for statistically significant enumeration. With this knowledge of D values, sensible margins can be applied in a planetary protection specification. The outcome of this study provided an optimization of test sterilizer process conditions: VHP concentration, process duration, a process temperature range for which the worst case D value may be imposed, a process humidity range for which the worst case D value may be imposed, and robustness to selected spacecraft material substrates.

Comparison of temporal realistic telecommunication base station exposure with worst-case estimation in two countries.

PubMed

Mahfouz, Zaher; Verloock, Leen; Joseph, Wout; Tanghe, Emmeric; Gati, Azeddine; Wiart, Joe; Lautru, David; Hanna, Victor Fouad; Martens, Luc

2013-12-01

The influence of temporal daily exposure to global system for mobile communications (GSM) and universal mobile telecommunications systems and high speed downlink packet access (UMTS-HSDPA) is investigated using spectrum analyser measurements in two countries, France and Belgium. Temporal variations and traffic distributions are investigated. Three different methods to estimate maximal electric-field exposure are compared. The maximal realistic (99 %) and the maximal theoretical extrapolation factor used to extrapolate the measured broadcast control channel (BCCH) for GSM and the common pilot channel (CPICH) for UMTS are presented and compared for the first time in the two countries. Similar conclusions are found in the two countries for both urban and rural areas: worst-case exposure assessment overestimates realistic maximal exposure up to 5.7 dB for the considered example. In France, the values are the highest, because of the higher population density. The results for the maximal realistic extrapolation factor at the weekdays are similar to those from weekend days.

Full band all-sky search for periodic gravitational waves in the O1 LIGO data

NASA Astrophysics Data System (ADS)

Abbott, B. P.; Abbott, R.; Abbott, T. D.; Acernese, F.; Ackley, K.; Adams, C.; Adams, T.; Addesso, P.; Adhikari, R. X.; Adya, V. B.; Affeldt, C.; Afrough, M.; Agarwal, B.; Agathos, M.; Agatsuma, K.; Aggarwal, N.; Aguiar, O. D.; Aiello, L.; Ain, A.; Allen, B.; Allen, G.; Allocca, A.; Altin, P. A.; Amato, A.; Ananyeva, A.; Anderson, S. B.; Anderson, W. G.; Angelova, S. V.; Antier, S.; Appert, S.; Arai, K.; Araya, M. C.; Areeda, J. S.; Arnaud, N.; Ascenzi, S.; Ashton, G.; Ast, M.; Aston, S. M.; Astone, P.; Atallah, D. V.; Aufmuth, P.; Aulbert, C.; AultONeal, K.; Austin, C.; Avila-Alvarez, A.; Babak, S.; Bacon, P.; Bader, M. K. M.; Bae, S.; Baker, P. T.; Baldaccini, F.; Ballardin, G.; Ballmer, S. W.; Banagiri, S.; Barayoga, J. C.; Barclay, S. E.; Barish, B. C.; Barker, D.; Barkett, K.; Barone, F.; Barr, B.; Barsotti, L.; Barsuglia, M.; Barta, D.; Bartlett, J.; Bartos, I.; Bassiri, R.; Basti, A.; Batch, J. C.; Bawaj, M.; Bayley, J. C.; Bazzan, M.; Bécsy, B.; Beer, C.; Bejger, M.; Belahcene, I.; Bell, A. S.; Berger, B. K.; Bergmann, G.; Bero, J. J.; Berry, C. P. L.; Bersanetti, D.; Bertolini, A.; Betzwieser, J.; Bhagwat, S.; Bhandare, R.; Bilenko, I. A.; Billingsley, G.; Billman, C. R.; Birch, J.; Birney, R.; Birnholtz, O.; Biscans, S.; Biscoveanu, S.; Bisht, A.; Bitossi, M.; Biwer, C.; Bizouard, M. A.; Blackburn, J. K.; Blackman, J.; Blair, C. D.; Blair, D. G.; Blair, R. M.; Bloemen, S.; Bock, O.; Bode, N.; Boer, M.; Bogaert, G.; Bohe, A.; Bondu, F.; Bonilla, E.; Bonnand, R.; Boom, B. A.; Bork, R.; Boschi, V.; Bose, S.; Bossie, K.; Bouffanais, Y.; Bozzi, A.; Bradaschia, C.; Brady, P. R.; Branchesi, M.; Brau, J. E.; Briant, T.; Brillet, A.; Brinkmann, M.; Brisson, V.; Brockill, P.; Broida, J. E.; Brooks, A. F.; Brown, D. A.; Brown, D. D.; Brunett, S.; Buchanan, C. C.; Buikema, A.; Bulik, T.; Bulten, H. J.; Buonanno, A.; Buskulic, D.; Buy, C.; Byer, R. L.; Cabero, M.; Cadonati, L.; Cagnoli, G.; Cahillane, C.; Bustillo, J. Calderón; Callister, T. A.; Calloni, E.; Camp, J. B.; Canepa, M.; Canizares, P.; Cannon, K. C.; Cao, H.; Cao, J.; Capano, C. D.; Capocasa, E.; Carbognani, F.; Caride, S.; Carney, M. F.; Casanueva Diaz, J.; Casentini, C.; Caudill, S.; Cavaglià, M.; Cavalier, F.; Cavalieri, R.; Cella, G.; Cepeda, C. B.; Cerdá-Durán, P.; Cerretani, G.; Cesarini, E.; Chamberlin, S. J.; Chan, M.; Chao, S.; Charlton, P.; Chase, E.; Chassande-Mottin, E.; Chatterjee, D.; Cheeseboro, B. D.; Chen, H. Y.; Chen, X.; Chen, Y.; Cheng, H.-P.; Chia, H. Y.; Chincarini, A.; Chiummo, A.; Chmiel, T.; Cho, H. S.; Cho, M.; Chow, J. H.; Christensen, N.; Chu, Q.; Chua, A. J. K.; Chua, S.; Chung, A. K. W.; Chung, S.; Ciani, G.; Ciecielag, P.; Ciolfi, R.; Cirelli, C. E.; Cirone, A.; Clara, F.; Clark, J. A.; Clearwater, P.; Cleva, F.; Cocchieri, C.; Coccia, E.; Cohadon, P.-F.; Cohen, D.; Colla, A.; Collette, C. G.; Cominsky, L. R.; Constancio, M.; Conti, L.; Cooper, S. J.; Corban, P.; Corbitt, T. R.; Cordero-Carrión, I.; Corley, K. R.; Cornish, N.; Corsi, A.; Cortese, S.; Costa, C. A.; Coughlin, E. T.; Coughlin, M. W.; Coughlin, S. B.; Coulon, J.-P.; Countryman, S. T.; Couvares, P.; Covas, P. B.; Cowan, E. E.; Coward, D. M.; Cowart, M. J.; Coyne, D. C.; Coyne, R.; Creighton, J. D. E.; Creighton, T. D.; Cripe, J.; Crowder, S. G.; Cullen, T. J.; Cumming, A.; Cunningham, L.; Cuoco, E.; Dal Canton, T.; Dálya, G.; Danilishin, S. L.; D'Antonio, S.; Danzmann, K.; Dasgupta, A.; Da Silva Costa, C. F.; Dattilo, V.; Dave, I.; Davier, M.; Davis, D.; Daw, E. J.; Day, B.; De, S.; DeBra, D.; Degallaix, J.; De Laurentis, M.; Deléglise, S.; Del Pozzo, W.; Demos, N.; Denker, T.; Dent, T.; De Pietri, R.; Dergachev, V.; De Rosa, R.; DeRosa, R. T.; De Rossi, C.; DeSalvo, R.; de Varona, O.; Devenson, J.; Dhurandhar, S.; Díaz, M. C.; Di Fiore, L.; Di Giovanni, M.; Di Girolamo, T.; Di Lieto, A.; Di Pace, S.; Di Palma, I.; Di Renzo, F.; Doctor, Z.; Dolique, V.; Donovan, F.; Dooley, K. L.; Doravari, S.; Dorosh, O.; Dorrington, I.; Douglas, R.; Dovale Álvarez, M.; Downes, T. P.; Drago, M.; Dreissigacker, C.; Driggers, J. C.; Du, Z.; Ducrot, M.; Dupej, P.; Dwyer, S. E.; Edo, T. B.; Edwards, M. C.; Effler, A.; Eggenstein, H.-B.; Ehrens, P.; Eichholz, J.; Eikenberry, S. S.; Eisenstein, R. A.; Essick, R. C.; Estevez, D.; Etienne, Z. B.; Etzel, T.; Evans, M.; Evans, T. M.; Factourovich, M.; Fafone, V.; Fair, H.; Fairhurst, S.; Fan, X.; Farinon, S.; Farr, B.; Farr, W. M.; Fauchon-Jones, E. J.; Favata, M.; Fays, M.; Fee, C.; Fehrmann, H.; Feicht, J.; Fejer, M. M.; Fernandez-Galiana, A.; Ferrante, I.; Ferreira, E. C.; Ferrini, F.; Fidecaro, F.; Finstad, D.; Fiori, I.; Fiorucci, D.; Fishbach, M.; Fisher, R. P.; Fitz-Axen, M.; Flaminio, R.; Fletcher, M.; Fong, H.; Font, J. A.; Forsyth, P. W. F.; Forsyth, S. S.; Fournier, J.-D.; Frasca, S.; Frasconi, F.; Frei, Z.; Freise, A.; Frey, R.; Frey, V.; Fries, E. M.; Fritschel, P.; Frolov, V. V.; Fulda, P.; Fyffe, M.; Gabbard, H.; Gadre, B. U.; Gaebel, S. M.; Gair, J. R.; Gammaitoni, L.; Ganija, M. R.; Gaonkar, S. G.; Garcia-Quiros, C.; Garufi, F.; Gateley, B.; Gaudio, S.; Gaur, G.; Gayathri, V.; Gehrels, N.; Gemme, G.; Genin, E.; Gennai, A.; George, D.; George, J.; Gergely, L.; Germain, V.; Ghonge, S.; Ghosh, Abhirup; Ghosh, Archisman; Ghosh, S.; Giaime, J. A.; Giardina, K. D.; Giazotto, A.; Gill, K.; Glover, L.; Goetz, E.; Goetz, R.; Gomes, S.; Goncharov, B.; González, G.; Gonzalez Castro, J. M.; Gopakumar, A.; Gorodetsky, M. L.; Gossan, S. E.; Gosselin, M.; Gouaty, R.; Grado, A.; Graef, C.; Granata, M.; Grant, A.; Gras, S.; Gray, C.; Greco, G.; Green, A. C.; Gretarsson, E. M.; Groot, P.; Grote, H.; Grunewald, S.; Gruning, P.; Guidi, G. M.; Guo, X.; Gupta, A.; Gupta, M. K.; Gushwa, K. E.; Gustafson, E. K.; Gustafson, R.; Halim, O.; Hall, B. R.; Hall, E. D.; Hamilton, E. Z.; Hammond, G.; Haney, M.; Hanke, M. M.; Hanks, J.; Hanna, C.; Hannam, M. D.; Hannuksela, O. A.; Hanson, J.; Hardwick, T.; Harms, J.; Harry, G. M.; Harry, I. W.; Hart, M. J.; Haster, C.-J.; Haughian, K.; Healy, J.; Heidmann, A.; Heintze, M. C.; Heitmann, H.; Hello, P.; Hemming, G.; Hendry, M.; Heng, I. S.; Hennig, J.; Heptonstall, A. W.; Heurs, M.; Hild, S.; Hinderer, T.; Hoak, D.; Hofman, D.; Holt, K.; Holz, D. E.; Hopkins, P.; Horst, C.; Hough, J.; Houston, E. A.; Howell, E. J.; Hreibi, A.; Hu, Y. M.; Huerta, E. A.; Huet, D.; Hughey, B.; Husa, S.; Huttner, S. H.; Huynh-Dinh, T.; Indik, N.; Inta, R.; Intini, G.; Isa, H. N.; Isac, J.-M.; Isi, M.; Iyer, B. R.; Izumi, K.; Jacqmin, T.; Jani, K.; Jaranowski, P.; Jawahar, S.; Jiménez-Forteza, F.; Johnson, W. W.; Jones, D. I.; Jones, R.; Jonker, R. J. G.; Ju, L.; Junker, J.; Kalaghatgi, C. V.; Kalogera, V.; Kamai, B.; Kandhasamy, S.; Kang, G.; Kanner, J. B.; Kapadia, S. J.; Karki, S.; Karvinen, K. S.; Kasprzack, M.; Katolik, M.; Katsavounidis, E.; Katzman, W.; Kaufer, S.; Kawabe, K.; Kéfélian, F.; Keitel, D.; Kemball, A. J.; Kennedy, R.; Kent, C.; Key, J. S.; Khalili, F. Y.; Khan, I.; Khan, S.; Khan, Z.; Khazanov, E. A.; Kijbunchoo, N.; Kim, Chunglee; Kim, J. C.; Kim, K.; Kim, W.; Kim, W. S.; Kim, Y.-M.; Kimbrell, S. J.; King, E. J.; King, P. J.; Kinley-Hanlon, M.; Kirchhoff, R.; Kissel, J. S.; Kleybolte, L.; Klimenko, S.; Knowles, T. D.; Koch, P.; Koehlenbeck, S. M.; Koley, S.; Kondrashov, V.; Kontos, A.; Korobko, M.; Korth, W. Z.; Kowalska, I.; Kozak, D. B.; Krämer, C.; Kringel, V.; Krishnan, B.; Królak, A.; Kuehn, G.; Kumar, P.; Kumar, R.; Kumar, S.; Kuo, L.; Kutynia, A.; Kwang, S.; Lackey, B. D.; Lai, K. H.; Landry, M.; Lang, R. N.; Lange, J.; Lantz, B.; Lanza, R. K.; Lartaux-Vollard, A.; Lasky, P. D.; Laxen, M.; Lazzarini, A.; Lazzaro, C.; Leaci, P.; Leavey, S.; Lee, C. H.; Lee, H. K.; Lee, H. M.; Lee, H. W.; Lee, K.; Lehmann, J.; Lenon, A.; Leonardi, M.; Leroy, N.; Letendre, N.; Levin, Y.; Li, T. G. F.; Linker, S. D.; Littenberg, T. B.; Liu, J.; Lo, R. K. L.; Lockerbie, N. A.; London, L. T.; Lord, J. E.; Lorenzini, M.; Loriette, V.; Lormand, M.; Losurdo, G.; Lough, J. D.; Lovelace, G.; Lück, H.; Lumaca, D.; Lundgren, A. P.; Lynch, R.; Ma, Y.; Macas, R.; Macfoy, S.; Machenschalk, B.; MacInnis, M.; Macleod, D. M.; Magaña Hernandez, I.; Magaña-Sandoval, F.; Magaña Zertuche, L.; Magee, R. M.; Majorana, E.; Maksimovic, I.; Man, N.; Mandic, V.; Mangano, V.; Mansell, G. L.; Manske, M.; Mantovani, M.; Marchesoni, F.; Marion, F.; Márka, S.; Márka, Z.; Markakis, C.; Markosyan, A. S.; Markowitz, A.; Maros, E.; Marquina, A.; Martelli, F.; Martellini, L.; Martin, I. W.; Martin, R. M.; Martynov, D. V.; Mason, K.; Massera, E.; Masserot, A.; Massinger, T. J.; Masso-Reid, M.; Mastrogiovanni, S.; Matas, A.; Matichard, F.; Matone, L.; Mavalvala, N.; Mazumder, N.; McCarthy, R.; McClelland, D. E.; McCormick, S.; McCuller, L.; McGuire, S. C.; McIntyre, G.; McIver, J.; McManus, D. J.; McNeill, L.; McRae, T.; McWilliams, S. T.; Meacher, D.; Meadors, G. D.; Mehmet, M.; Meidam, J.; Mejuto-Villa, E.; Melatos, A.; Mendell, G.; Mercer, R. A.; Merilh, E. L.; Merzougui, M.; Meshkov, S.; Messenger, C.; Messick, C.; Metzdorff, R.; Meyers, P. M.; Miao, H.; Michel, C.; Middleton, H.; Mikhailov, E. E.; Milano, L.; Miller, A. L.; Miller, B. B.; Miller, J.; Millhouse, M.; Milovich-Goff, M. C.; Minazzoli, O.; Minenkov, Y.; Ming, J.; Mishra, C.; Mitra, S.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Moffa, D.; Moggi, A.; Mogushi, K.; Mohan, M.; Mohapatra, S. R. P.; Montani, M.; Moore, C. J.; Moraru, D.; Moreno, G.; Morriss, S. R.; Mours, B.; Mow-Lowry, C. M.; Mueller, G.; Muir, A. W.; Mukherjee, Arunava; Mukherjee, D.; Mukherjee, S.; Mukund, N.; Mullavey, A.; Munch, J.; Muñiz, E. A.; Muratore, M.; Murray, P. G.; Napier, K.; Nardecchia, I.; Naticchioni, L.; Nayak, R. K.; Neilson, J.; Nelemans, G.; Nelson, T. J. N.; Nery, M.; Neunzert, A.; Nevin, L.; Newport, J. M.; Newton, G.; Ng, K. Y.; Nguyen, T. T.; Nichols, D.; Nielsen, A. B.; Nissanke, S.; Nitz, A.; Noack, A.; Nocera, F.; Nolting, D.; North, C.; Nuttall, L. K.; Oberling, J.; O'Dea, G. D.; Ogin, G. H.; Oh, J. J.; Oh, S. H.; Ohme, F.; Okada, M. A.; Oliver, M.; Oppermann, P.; Oram, Richard J.; O'Reilly, B.; Ormiston, R.; Ortega, L. F.; O'Shaughnessy, R.; Ossokine, S.; Ottaway, D. J.; Overmier, H.; Owen, B. J.; Pace, A. E.; Page, J.; Page, M. A.; Pai, A.; Pai, S. A.; Palamos, J. R.; Palashov, O.; Palomba, C.; Pal-Singh, A.; Pan, Howard; Pan, Huang-Wei; Pang, B.; Pang, P. T. H.; Pankow, C.; Pannarale, F.; Pant, B. C.; Paoletti, F.; Paoli, A.; Papa, M. A.; Parida, A.; Parker, W.; Pascucci, D.; Pasqualetti, A.; Passaquieti, R.; Passuello, D.; Patil, M.; Patricelli, B.; Pearlstone, B. L.; Pedraza, M.; Pedurand, R.; Pekowsky, L.; Pele, A.; Penn, S.; Perez, C. J.; Perreca, A.; Perri, L. M.; Pfeiffer, H. P.; Phelps, M.; Piccinni, O. J.; Pichot, M.; Piergiovanni, F.; Pierro, V.; Pillant, G.; Pinard, L.; Pinto, I. M.; Pirello, M.; Pisarski, A.; Pitkin, M.; Poe, M.; Poggiani, R.; Popolizio, P.; Porter, E. K.; Post, A.; Powell, J.; Prasad, J.; Pratt, J. W. W.; Pratten, G.; Predoi, V.; Prestegard, T.; Prijatelj, M.; Principe, M.; Privitera, S.; Prodi, G. A.; Prokhorov, L. G.; Puncken, O.; Punturo, M.; Puppo, P.; Pürrer, M.; Qi, H.; Quetschke, V.; Quintero, E. A.; Quitzow-James, R.; Raab, F. J.; Rabeling, D. S.; Radkins, H.; Raffai, P.; Raja, S.; Rajan, C.; Rajbhandari, B.; Rakhmanov, M.; Ramirez, K. E.; Ramos-Buades, A.; Rapagnani, P.; Raymond, V.; Razzano, M.; Read, J.; Regimbau, T.; Rei, L.; Reid, S.; Reitze, D. H.; Ren, W.; Reyes, S. D.; Ricci, F.; Ricker, P. M.; Rieger, S.; Riles, K.; Rizzo, M.; Robertson, N. A.; Robie, R.; Robinet, F.; Rocchi, A.; Rolland, L.; Rollins, J. G.; Roma, V. J.; Romano, R.; Romel, C. L.; Romie, J. H.; Rosińska, D.; Ross, M. P.; Rowan, S.; Rüdiger, A.; Ruggi, P.; Rutins, G.; Ryan, K.; Sachdev, S.; Sadecki, T.; Sadeghian, L.; Sakellariadou, M.; Salconi, L.; Saleem, M.; Salemi, F.; Samajdar, A.; Sammut, L.; Sampson, L. M.; Sanchez, E. J.; Sanchez, L. E.; Sanchis-Gual, N.; Sandberg, V.; Sanders, J. R.; Sassolas, B.; Saulson, P. R.; Sauter, O.; Savage, R. L.; Sawadsky, A.; Schale, P.; Scheel, M.; Scheuer, J.; Schmidt, J.; Schmidt, P.; Schnabel, R.; Schofield, R. M. S.; Schönbeck, A.; Schreiber, E.; Schuette, D.; Schulte, B. W.; Schutz, B. F.; Schwalbe, S. G.; Scott, J.; Scott, S. M.; Seidel, E.; Sellers, D.; Sengupta, A. S.; Sentenac, D.; Sequino, V.; Sergeev, A.; Shaddock, D. A.; Shaffer, T. J.; Shah, A. A.; Shahriar, M. S.; Shaner, M. B.; Shao, L.; Shapiro, B.; Shawhan, P.; Sheperd, A.; Shoemaker, D. H.; Shoemaker, D. M.; Siellez, K.; Siemens, X.; Sieniawska, M.; Sigg, D.; Silva, A. D.; Singer, L. P.; Singh, A.; Singhal, A.; Sintes, A. M.; Slagmolen, B. J. J.; Smith, B.; Smith, J. R.; Smith, R. J. E.; Somala, S.; Son, E. J.; Sonnenberg, J. A.; Sorazu, B.; Sorrentino, F.; Souradeep, T.; Spencer, A. P.; Srivastava, A. K.; Staats, K.; Staley, A.; Steinke, M.; Steinlechner, J.; Steinlechner, S.; Steinmeyer, D.; Stevenson, S. P.; Stone, R.; Stops, D. J.; Strain, K. A.; Stratta, G.; Strigin, S. E.; Strunk, A.; Sturani, R.; Stuver, A. L.; Summerscales, T. Z.; Sun, L.; Sunil, S.; Suresh, J.; Sutton, P. J.; Swinkels, B. L.; Szczepańczyk, M. J.; Tacca, M.; Tait, S. C.; Talbot, C.; Talukder, D.; Tanner, D. B.; Tao, D.; Tápai, M.; Taracchini, A.; Tasson, J. D.; Taylor, J. A.; Taylor, R.; Tewari, S. V.; Theeg, T.; Thies, F.; Thomas, E. G.; Thomas, M.; Thomas, P.; Thorne, K. A.; Thrane, E.; Tiwari, S.; Tiwari, V.; Tokmakov, K. V.; Toland, K.; Tonelli, M.; Tornasi, Z.; Torres-Forné, A.; Torrie, C. I.; Töyrä, D.; Travasso, F.; Traylor, G.; Trinastic, J.; Tringali, M. C.; Trozzo, L.; Tsang, K. W.; Tse, M.; Tso, R.; Tsukada, L.; Tsuna, D.; Tuyenbayev, D.; Ueno, K.; Ugolini, D.; Unnikrishnan, C. S.; Urban, A. L.; Usman, S. A.; Vahlbruch, H.; Vajente, G.; Valdes, G.; van Bakel, N.; van Beuzekom, M.; van den Brand, J. F. J.; Van Den Broeck, C.; Vander-Hyde, D. C.; van der Schaaf, L.; van Heijningen, J. V.; van Veggel, A. A.; Vardaro, M.; Varma, V.; Vass, S.; Vasúth, M.; Vecchio, A.; Vedovato, G.; Veitch, J.; Veitch, P. J.; Venkateswara, K.; Venugopalan, G.; Verkindt, D.; Vetrano, F.; Viceré, A.; Viets, A. D.; Vinciguerra, S.; Vine, D. J.; Vinet, J.-Y.; Vitale, S.; Vo, T.; Vocca, H.; Vorvick, C.; Vyatchanin, S. P.; Wade, A. R.; Wade, L. E.; Wade, M.; Walet, R.; Walker, M.; Wallace, L.; Walsh, S.; Wang, G.; Wang, H.; Wang, J. Z.; Wang, W. H.; Wang, Y. F.; Ward, R. L.; Warner, J.; Was, M.; Watchi, J.; Weaver, B.; Wei, L.-W.; Weinert, M.; Weinstein, A. J.; Weiss, R.; Wen, L.; Wessel, E. K.; Weßels, P.; Westerweck, J.; Westphal, T.; Wette, K.; Whelan, J. T.; Whiting, B. F.; Whittle, C.; Wilken, D.; Williams, D.; Williams, R. D.; Williamson, A. R.; Willis, J. L.; Willke, B.; Wimmer, M. H.; Winkler, W.; Wipf, C. C.; Wittel, H.; Woan, G.; Woehler, J.; Wofford, J.; Wong, W. K.; Worden, J.; Wright, J. L.; Wu, D. S.; Wysocki, D. M.; Xiao, S.; Yamamoto, H.; Yancey, C. C.; Yang, L.; Yap, M. J.; Yazback, M.; Yu, Hang; Yu, Haocun; Yvert, M.; Zadroźny, A.; Zanolin, M.; Zelenova, T.; Zendri, J.-P.; Zevin, M.; Zhang, L.; Zhang, M.; Zhang, T.; Zhang, Y.-H.; Zhao, C.; Zhou, M.; Zhou, Z.; Zhu, S. J.; Zhu, X. J.; Zucker, M. E.; Zweizig, J.; LIGO Scientific Collaboration; Virgo Collaboration

2018-05-01

We report on a new all-sky search for periodic gravitational waves in the frequency band 475-2000 Hz and with a frequency time derivative in the range of [-1.0 ,+0.1 ] ×1 0-8 Hz /s . Potential signals could be produced by a nearby spinning and slightly nonaxisymmetric isolated neutron star in our Galaxy. This search uses the data from Advanced LIGO's first observational run O1. No gravitational-wave signals were observed, and upper limits were placed on their strengths. For completeness, results from the separately published low-frequency search 20-475 Hz are included as well. Our lowest upper limit on worst-case (linearly polarized) strain amplitude h0 is ˜4 ×1 0-25 near 170 Hz, while at the high end of our frequency range, we achieve a worst-case upper limit of 1.3 ×1 0-24. For a circularly polarized source (most favorable orientation), the smallest upper limit obtained is ˜1.5 ×1 0-25.

Quantum systems as embarrassed colleagues: what do tax evasion and state tomography have in common?

NASA Astrophysics Data System (ADS)

Ferrie, Chris; Blume-Kohout, Robin

2011-03-01

Quantum state estimation (a.k.a. ``tomography'') plays a key role in designing quantum information processors. As a problem, it resembles probability estimation - e.g. for classical coins or dice - but with some subtle and important discrepancies. We demonstrate an improved classical analogue that captures many of these differences: the ``noisy coin.'' Observations on noisy coins are unreliable - much like soliciting sensitive information such as ones tax preparation habits. So, like a quantum system, it cannot be sampled directly. Unlike standard coins or dice, whose worst-case estimation risk scales as 1 / N for all states, noisy coins (and quantum states) have a worst-case risk that scales as 1 /√{ N } and is overwhelmingly dominated by nearly-pure states. The resulting optimal estimation strategies for noisy coins are surprising and counterintuitive. We demonstrate some important consequences for quantum state estimation - in particular, that adaptive tomography can recover the 1 / N risk scaling of classical probability estimation.

Derivation and experimental verification of clock synchronization theory

NASA Technical Reports Server (NTRS)

Palumbo, Daniel L.

1994-01-01

The objective of this work is to validate mathematically derived clock synchronization theories and their associated algorithms through experiment. Two theories are considered, the Interactive Convergence Clock Synchronization Algorithm and the Mid-Point Algorithm. Special clock circuitry was designed and built so that several operating conditions and failure modes (including malicious failures) could be tested. Both theories are shown to predict conservative upper bounds (i.e., measured values of clock skew were always less than the theory prediction). Insight gained during experimentation led to alternative derivations of the theories. These new theories accurately predict the clock system's behavior. It is found that a 100% penalty is paid to tolerate worst case failures. It is also shown that under optimal conditions (with minimum error and no failures) the clock skew can be as much as 3 clock ticks. Clock skew grows to 6 clock ticks when failures are present. Finally, it is concluded that one cannot rely solely on test procedures or theoretical analysis to predict worst case conditions. conditions.

Experimental validation of clock synchronization algorithms

NASA Technical Reports Server (NTRS)

Palumbo, Daniel L.; Graham, R. Lynn

1992-01-01

The objective of this work is to validate mathematically derived clock synchronization theories and their associated algorithms through experiment. Two theories are considered, the Interactive Convergence Clock Synchronization Algorithm and the Midpoint Algorithm. Special clock circuitry was designed and built so that several operating conditions and failure modes (including malicious failures) could be tested. Both theories are shown to predict conservative upper bounds (i.e., measured values of clock skew were always less than the theory prediction). Insight gained during experimentation led to alternative derivations of the theories. These new theories accurately predict the behavior of the clock system. It is found that a 100 percent penalty is paid to tolerate worst-case failures. It is also shown that under optimal conditions (with minimum error and no failures) the clock skew can be as much as three clock ticks. Clock skew grows to six clock ticks when failures are present. Finally, it is concluded that one cannot rely solely on test procedures or theoretical analysis to predict worst-case conditions.

Direct simulation Monte Carlo prediction of on-orbit contaminant deposit levels for HALOE

NASA Technical Reports Server (NTRS)

Woronowicz, Michael S.; Rault, Didier F. G.

1994-01-01

A three-dimensional version of the direct simulation Monte Carlo method is adapted to assess the contamination environment surrounding a highly detailed model of the Upper Atmosphere Research Satellite. Emphasis is placed on simulating a realistic, worst-case set of flow field and surface conditions and geometric orientations for the satellite in order to estimate an upper limit for the cumulative level of volatile organic molecular deposits at the aperture of the Halogen Occultation Experiment. A detailed description of the adaptation of this solution method to the study of the satellite's environment is also presented. Results pertaining to the satellite's environment are presented regarding contaminant cloud structure, cloud composition, and statistics of simulated molecules impinging on the target surface, along with data related to code performance. Using procedures developed in standard contamination analyses, along with many worst-case assumptions, the cumulative upper-limit level of volatile organic deposits on HALOE's aperture over the instrument's 35-month nominal data collection period is estimated at about 13,350 A.

Correct consideration of the index of refraction using blackbody radiation.

PubMed

Hartmann, Jurgen

2006-09-04

The correct consideration of the index of refraction when using blackbody radiators as standard sources for optical radiation is derived and discussed. It is shown that simply using the index of refraction of air at laboratory conditions is not sufficient. A combination of the index of refraction of the media used inside the blackbody radiator and for the optical path between blackbody and detector has to be used instead. A worst case approximation for the introduced error when neglecting these effects is presented, showing that the error is below 0.1 % for wavelengths above 200 nm. Nevertheless, for the determination of the spectral radiance for the purpose of radiation temperature measurements the correct consideration of the refractive index is mandatory. The worst case estimation reveals that the introduced error in temperature at a blackbody temperature of 3000 degrees C can be as high as 400 mk at a wavelength of 650 nm and even higher at longer wavelengths.

Thermal-hydraulic analysis of N Reactor graphite and shield cooling system performance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Low, J.O.; Schmitt, B.E.

1988-02-01

A series of bounding (worst-case) calculations were performed using a detailed hydrodynamic RELAP5 model of the N Reactor graphite and shield cooling system (GSCS). These calculations were specifically aimed to answer issues raised by the Westinghouse Independent Safety Review (WISR) committee. These questions address the operability of the GSCS during a worst-case degraded-core accident that requires the GDCS to mitigate the consequences of the accident. An accident scenario previously developed was designed as the hydrogen-mitigation design-basis accident (HMDBA). Previous HMDBA heat transfer analysis,, using the TRUMP-BD code, was used to define the thermal boundary conditions that the GSDS may bemore » exposed to. These TRUMP/HMDBA analysis results were used to define the bounding operating conditions of the GSCS during the course of an HMDBA transient. Nominal and degraded GSCS scenarios were investigated using RELAP5 within or at the bounds of the HMDBA transient. 10 refs., 42 figs., 10 tabs.« less

Zero-moment point determination of worst-case manoeuvres leading to vehicle wheel lift

NASA Astrophysics Data System (ADS)

Lapapong, S.; Brown, A. A.; Swanson, K. S.; Brennan, S. N.

2012-01-01

This paper proposes a method to evaluate vehicle rollover propensity based on a frequency-domain representation of the zero-moment point (ZMP). Unlike other rollover metrics such as the static stability factor, which is based on the steady-state behaviour, and the load transfer ratio, which requires the calculation of tyre forces, the ZMP is based on a simplified kinematic model of the vehicle and the analysis of the contact point of the vehicle relative to the edge of the support polygon. Previous work has validated the use of the ZMP experimentally in its ability to predict wheel lift in the time domain. This work explores the use of the ZMP in the frequency domain to allow a chassis designer to understand how operating conditions and vehicle parameters affect rollover propensity. The ZMP analysis is then extended to calculate worst-case sinusoidal manoeuvres that lead to untripped wheel lift, and the analysis is tested across several vehicle configurations and compared with that of the standard Toyota J manoeuvre.

Level II scour analysis for Bridge 37, (BRNETH00740037) on Town Highway 74, crossing South Peacham Brook, Barnet, Vermont

USGS Publications Warehouse

Burns, Ronda L.; Severance, Timothy

1997-01-01

Contraction scour for all modelled flows ranged from 15.8 to 22.5 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 6.7 to 11.1 ft. The worst-case abutment scour also occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in Tables 1 and 2. A cross-section of the scour computed at the bridge is presented in Figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

DCT-based iris recognition.

PubMed

Monro, Donald M; Rakshit, Soumyadip; Zhang, Dexin

2007-04-01

This paper presents a novel iris coding method based on differences of discrete cosine transform (DCT) coefficients of overlapped angular patches from normalized iris images. The feature extraction capabilities of the DCT are optimized on the two largest publicly available iris image data sets, 2,156 images of 308 eyes from the CASIA database and 2,955 images of 150 eyes from the Bath database. On this data, we achieve 100 percent Correct Recognition Rate (CRR) and perfect Receiver-Operating Characteristic (ROC) Curves with no registered false accepts or rejects. Individual feature bit and patch position parameters are optimized for matching through a product-of-sum approach to Hamming distance calculation. For verification, a variable threshold is applied to the distance metric and the False Acceptance Rate (FAR) and False Rejection Rate (FRR) are recorded. A new worst-case metric is proposed for predicting practical system performance in the absence of matching failures, and the worst case theoretical Equal Error Rate (EER) is predicted to be as low as 2.59 x 10(-4) on the available data sets.

A CMOS matrix for extracting MOSFET parameters before and after irradiation

NASA Technical Reports Server (NTRS)

Blaes, B. R.; Buehler, M. G.; Lin, Y.-S.; Hicks, K. A.

1988-01-01

An addressable matrix of 16 n- and 16 p-MOSFETs was designed to extract the dc MOSFET parameters for all dc gate bias conditions before and after irradiation. The matrix contains four sets of MOSFETs, each with four different geometries that can be biased independently. Thus the worst-case bias scenarios can be determined. The MOSFET matrix was fabricated at a silicon foundry using a radiation-soft CMOS p-well LOCOS process. Co-60 irradiation results for the n-MOSFETs showed a threshold-voltage shift of -3 mV/krad(Si), whereas the p-MOSFETs showed a shift of 21 mV/krad(Si). The worst-case threshold-voltage shift occurred for the n-MOSFETs, with a gate bias of 5 V during the anneal. For the p-MOSFETs, biasing did not affect the shift in the threshold voltage. A parasitic MOSFET dominated the leakage of the n-MOSFET biased with 5 V on the gate during irradiation. Co-60 test results for other parameters are also presented.

Mad cows and computer models: the U.S. response to BSE.

PubMed

Ackerman, Frank; Johnecheck, Wendy A

2008-01-01

The proportion of slaughtered cattle tested for BSE is much smaller in the U.S. than in Europe and Japan, leaving the U.S. heavily dependent on statistical models to estimate both the current prevalence and the spread of BSE. We examine the models relied on by USDA, finding that the prevalence model provides only a rough estimate, due to limited data availability. Reassuring forecasts from the model of the spread of BSE depend on the arbitrary constraint that worst-case values are assumed by only one of 17 key parameters at a time. In three of the six published scenarios with multiple worst-case parameter values, there is at least a 25% probability that BSE will spread rapidly. In public policy terms, reliance on potentially flawed models can be seen as a gamble that no serious BSE outbreak will occur. Statistical modeling at this level of abstraction, with its myriad, compound uncertainties, is no substitute for precautionary policies to protect public health against the threat of epidemics such as BSE.

Modelling the long-term evolution of worst-case Arctic oil spills.

PubMed

Blanken, Hauke; Tremblay, Louis Bruno; Gaskin, Susan; Slavin, Alexander

2017-03-15

We present worst-case assessments of contamination in sea ice and surface waters resulting from hypothetical well blowout oil spills at ten sites in the Arctic Ocean basin. Spill extents are estimated by considering Eulerian passive tracers in the surface ocean of the MITgcm (a hydrostatic, coupled ice-ocean model). Oil in sea ice, and contamination resulting from melting of oiled ice, is tracked using an offline Lagrangian scheme. Spills are initialized on November 1st 1980-2010 and tracked for one year. An average spill was transported 1100km and potentially affected 1.1 million km 2 . The direction and magnitude of simulated oil trajectories are consistent with known large-scale current and sea ice circulation patterns, and trajectories frequently cross international boundaries. The simulated trajectories of oil in sea ice match observed ice drift trajectories well. During the winter oil transport by drifting sea ice is more significant than transport with surface currents. Copyright © 2017 Elsevier Ltd. All rights reserved.

Multiple Microcomputer Control Algorithm.

DTIC Science & Technology

1979-09-01

discrete and semaphore supervisor calls can be used with tasks in separate processors, in which case they are maintained in shared memory. Operations on ...the source or destination operand specifier of each mode in most cases . However, four of the 16 general register addressing modes and one of the 8 pro...instruction time is based on the specified usage factors and the best cast, and worst case execution times for the instruc- 1I 5 1NAVTRAEQZJ1PCrN M’.V7~j

Performance evaluation of restaurant food waste and biowaste to biogas pilot projects in China and implications for national policy.

PubMed

De Clercq, Djavan; Wen, Zongguo; Fan, Fei

2017-03-15

The objective of this research was to conduct a performance evaluation of three food waste/biowaste-to-biogas pilot projects across 7 scenarios in China based on multi-criteria decision analysis (MCDA) methodology. The projects ranked included a food waste-biogas project in Beijing, a food waste-biogas project in Suzhou and a co-digestion project producing biomethane in Hainan. The projects were ranked from best to worst based on technical, economic and environmental criteria under the MCDA framework. The results demonstrated that some projects are encountering operational problems. Based on these findings, six national policy recommendations were provided: (1) shift away from capital investment subsidies to performance-based subsidies; (2) re-design feed in tariffs; (3) promote bio-methane and project clustering; (4) improve collection efficiency by incentivizing FW producers to direct waste to biogas projects; (5) incentivize biogas projects to produce multiple outputs; (6) incentivize food waste-based projects to co-digest food waste with other substrates for higher gas output. Copyright © 2016 Elsevier Ltd. All rights reserved.

A Framework for Multi-Stakeholder Decision-Making and ...

EPA Pesticide Factsheets

This contribution describes the implementation of the conditional-value-at-risk (CVaR) metric to create a general multi-stakeholder decision-making framework. It is observed that stakeholder dissatisfactions (distance to their individual ideal solutions) can be interpreted as random variables. We thus shape the dissatisfaction distribution and find an optimal compromise solution by solving a CVaR minimization problem parameterized in the probability level. This enables us to generalize multi-stakeholder settings previously proposed in the literature that minimizes average and worst-case dissatisfactions. We use the concept of the CVaR norm to give a geometric interpretation to this problem and use the properties of this norm to prove that the CVaR minimization problem yields Pareto optimal solutions for any choice of the probability level. We discuss a broad range of potential applications of the framework. We demonstrate the framework in a bio-waste processing facility location case study, where we seek compromise solutions (facility locations) that balance stakeholder priorities on transportation, safety, water quality, and capital costs. This conference presentation abstract explains a new decision-making framework that computes compromise solution alternatives (reach consensus) by mitigating dissatisfactions among stakeholders as needed for SHC Decision Science and Support Tools project.

Detailed Uncertainty Analysis of the Ares I A106 Liftoff/Transition Database

NASA Technical Reports Server (NTRS)

Hanke, Jeremy L.

2011-01-01

The Ares I A106 Liftoff/Transition Force and Moment Aerodynamics Database describes the aerodynamics of the Ares I Crew Launch Vehicle (CLV) from the moment of liftoff through the transition from high to low total angles of attack at low subsonic Mach numbers. The database includes uncertainty estimates that were developed using a detailed uncertainty quantification procedure. The Ares I Aerodynamics Panel developed both the database and the uncertainties from wind tunnel test data acquired in the NASA Langley Research Center s 14- by 22-Foot Subsonic Wind Tunnel Test 591 using a 1.75 percent scale model of the Ares I and the tower assembly. The uncertainty modeling contains three primary uncertainty sources: experimental uncertainty, database modeling uncertainty, and database query interpolation uncertainty. The final database and uncertainty model represent a significant improvement in the quality of the aerodynamic predictions for this regime of flight over the estimates previously used by the Ares Project. The maximum possible aerodynamic force pushing the vehicle towards the launch tower assembly in a dispersed case using this database saw a 40 percent reduction from the worst-case scenario in previously released data for Ares I.

Investigation of the Human Response to Upper Torso Retraction with Weighted Helmets

DTIC Science & Technology

2013-09-01

coverage of each test. The Kodak system is capable of recording high-speed motion up to a rate of 1000 frames per second. For this study , the video...the measured center-of-gravity (CG) of the worst- case test helmet fell outside the current limits and no injuries were observed, it can be stated...8 Figure 7. T-test Cases 1-9 (0 lb Added Helmet Weight

Walsh Preprocessor.

DTIC Science & Technology

1980-08-01

tile se(q uenw threshold does not utilize thle D)C level inlforiat ion and the time thlresliolditig adaptively adjusts for DC lvel . 𔃻This characteristic...lowest 256/8 = 32 elements. The above observation can be mathematically proven to also relate the fact that the lowest (NT/W) elements can, at worst case

When Food Is a Foe.

ERIC Educational Resources Information Center

Fitzgerald, Patricia L.

1998-01-01

Although only 5% of the population has severe food allergies, school business officials must be prepared for the worst-case scenario. Banning foods and segregating allergic children are harmful practices. Education and sensible behavior are the best medicine when food allergies and intolerances are involved. Resources are listed. (MLH)

Shuttle ECLSS ammonia delivery capability

NASA Technical Reports Server (NTRS)

1976-01-01

The possible effects of excessive requirements on ammonia flow rates required for entry cooling, due to extreme temperatures, on mission plans for the space shuttles, were investigated. An analysis of worst case conditions was performed, and indicates that adequate flow rates are available. No mission impact is therefore anticipated.

41 CFR 102-80.145 - What is meant by “flashover”?

Code of Federal Regulations, 2010 CFR

2010-07-01

...”? Flashover means fire conditions in a confined area where the upper gas layer temperature reaches 600 °C (1100 °F) and the heat flux at floor level exceeds 20 kW/m2 (1.8 Btu/ft2/sec). Reasonable Worst Case...

41 CFR 102-80.145 - What is meant by “flashover”?

Code of Federal Regulations, 2011 CFR

2011-01-01

...”? Flashover means fire conditions in a confined area where the upper gas layer temperature reaches 600 °C (1100 °F) and the heat flux at floor level exceeds 20 kW/m2 (1.8 Btu/ft2/sec). Reasonable Worst Case...

Independent Orbiter Assessment (IOA): FMEA/CIL assessment

NASA Technical Reports Server (NTRS)

Saiidi, Mo J.; Swain, L. J.; Compton, J. M.

1988-01-01

The results of the Independent Orbiter Assessment (IOA) of the Failure Modes and Effects Analysis (FMEA) and Critical Items List (CIL) are presented. Direction was given by the Orbiter and GFE Projects Office to perform the hardware analysis and assessment using the instructions and ground rules defined in NSTS 22206. The IOA analysis features a top-down approach to determine hardware failure modes, criticality, and potential critical items. To preserve independence, the anlaysis was accomplished without reliance upon the results contained within the NASA and prime contractor FMEA/CIL documentation. The assessment process compares the independently derived failure modes and criticality assignments to the proposed NASA Post 51-L FMEA/CIL documentation. When possible, assessment issues are discussed and resolved with the NASA subsystem managers. The assessment results for each subsystem are summarized. The most important Orbiter assessment finding was the previously unknown stuck autopilot push-button criticality 1/1 failure mode, having a worst case effect of loss of crew/vehicle when a microwave landing system is not active.

Resilient Grid Operational Strategies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pasqualini, Donatella

Extreme weather-related disturbances, such as hurricanes, are a leading cause of grid outages historically. Although physical asset hardening is perhaps the most common way to mitigate the impacts of severe weather, operational strategies may be deployed to limit the extent of societal and economic losses associated with weather-related physical damage.1 The purpose of this study is to examine bulk power-system operational strategies that can be deployed to mitigate the impact of severe weather disruptions caused by hurricanes, thereby increasing grid resilience to maintain continuity of critical infrastructure during extreme weather. To estimate the impacts of resilient grid operational strategies, Losmore » Alamos National Laboratory (LANL) developed a framework for hurricane probabilistic risk analysis (PRA). The probabilistic nature of this framework allows us to estimate the probability distribution of likely impacts, as opposed to the worst-case impacts. The project scope does not include strategies that are not operations related, such as transmission system hardening (e.g., undergrounding, transmission tower reinforcement and substation flood protection) and solutions in the distribution network.« less

Calibrated Multivariate Regression with Application to Neural Semantic Basis Discovery.

PubMed

Liu, Han; Wang, Lie; Zhao, Tuo

2015-08-01

We propose a calibrated multivariate regression method named CMR for fitting high dimensional multivariate regression models. Compared with existing methods, CMR calibrates regularization for each regression task with respect to its noise level so that it simultaneously attains improved finite-sample performance and tuning insensitiveness. Theoretically, we provide sufficient conditions under which CMR achieves the optimal rate of convergence in parameter estimation. Computationally, we propose an efficient smoothed proximal gradient algorithm with a worst-case numerical rate of convergence O (1/ ϵ ), where ϵ is a pre-specified accuracy of the objective function value. We conduct thorough numerical simulations to illustrate that CMR consistently outperforms other high dimensional multivariate regression methods. We also apply CMR to solve a brain activity prediction problem and find that it is as competitive as a handcrafted model created by human experts. The R package camel implementing the proposed method is available on the Comprehensive R Archive Network http://cran.r-project.org/web/packages/camel/.

Thermal Analysis of the NASA Integrated Vehicle Health Monitoring Experiment Technology for X-Vehicles (NITEX)

NASA Technical Reports Server (NTRS)

Hegab, Hisham E.

2002-01-01

The purpose of this project was to perform a thermal analysis for the NASA Integrated Vehicle Health Monitoring (IVHM) Technology Experiment for X-vehicles (NITEX). This electronics package monitors vehicle sensor information in flight and downlinks vehicle health summary information via telemetry. The experiment will be tested on the X-34 in an unpressurized compartment, in the vicinity of one of the vehicle's liquid oxygen tanks. The transient temperature profile for the electronics package has been determined using finite element analysis for possible mission profiles that will most likely expose the package to the most extreme hot and cold environmental conditions. From the analyses, it was determined that temperature limits for the electronics would be exceeded for the worst case cold environment mission profile. The finite element model used for the analyses was modified to examine the use of insulation to address this problem. Recommendations for insulating the experiment for the cold environment are presented, and were analyzed to determine their effect on a nominal mission profile.

Thermal Analysis Of The NASA Integrated Vehicle Health Monitoring Experiment Technology For X-Vehicles (NITEX)

NASA Technical Reports Server (NTRS)

Hegab, Hisham E.

2001-01-01

The purpose of this project was to perform a thermal analysis for the NASA Integrated Vehicle Health Monitoring (IVHM) Technology Experiment for X-vehicles (NITEX). This electronics package monitors vehicle sensor information in flight and downlinks vehicle health summary information via telemetry. The experiment will be tested on the X-34 in an unpressurized compartment, in the vicinity of one of the vehicle's liquid oxygen tanks. The transient temperature profile for the electronics package has been determined using finite element analysis for possible mission profiles that will most likely expose the package to the most extreme hot and cold environmental conditions. From the analyses, it was determined that temperature limits for the electronics would be exceeded for the worst case cold environment mission profile. The finite element model used for the analyses was modified to examine the use of insulation to address this problem. Recommendations for insulating the experiment for the cold environment are presented, and were analyzed to determine their effect on a nominal mission profile.

40 CFR 266.106 - Standards to control metals emissions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... HAZARDOUS WASTE MANAGEMENT FACILITIES Hazardous Waste Burned in Boilers and Industrial Furnaces § 266.106... implemented by limiting feed rates of the individual metals to levels during the trial burn (for new... screening limit for the worst-case stack. (d) Tier III and Adjusted Tier I site-specific risk assessment...

40 CFR 266.106 - Standards to control metals emissions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... HAZARDOUS WASTE MANAGEMENT FACILITIES Hazardous Waste Burned in Boilers and Industrial Furnaces § 266.106... implemented by limiting feed rates of the individual metals to levels during the trial burn (for new... screening limit for the worst-case stack. (d) Tier III and Adjusted Tier I site-specific risk assessment...

49 CFR 238.431 - Brake system.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Brake system. 238.431 Section 238.431... Equipment § 238.431 Brake system. (a) A passenger train's brake system shall be capable of stopping the... train is operating under worst-case adhesion conditions. (b) The brake system shall be designed to allow...

Assessment of the Incentives Created by Public Disclosure of Off-Site Consequence Analysis Information for Reduction in the Risk of Accidental Releases

EPA Pesticide Factsheets

The off-site consequence analysis (OCA) evaluates the potential for worst-case and alternative accidental release scenarios to harm the public and environment around the facility. Public disclosure would likely reduce the number/severity of incidents.

33 CFR 155.1230 - Response plan development and evaluation criteria.

Code of Federal Regulations, 2011 CFR

2011-07-01

... VESSELS Response plan requirements for vessels carrying animal fats and vegetable oils as a primary cargo... carry animal fats or vegetable oils as a primary cargo must provide information in their plan that identifies— (1) Procedures and strategies for responding to a worst case discharge of animal fats or...

33 CFR 155.1230 - Response plan development and evaluation criteria.

Code of Federal Regulations, 2010 CFR

2010-07-01

... VESSELS Response plan requirements for vessels carrying animal fats and vegetable oils as a primary cargo... carry animal fats or vegetable oils as a primary cargo must provide information in their plan that identifies— (1) Procedures and strategies for responding to a worst case discharge of animal fats or...

33 CFR 154.1029 - Worst case discharge.

Code of Federal Regulations, 2010 CFR

2010-07-01

... facility. The discharge from each pipe is calculated as follows: The maximum time to discover the release from the pipe in hours, plus the maximum time to shut down flow from the pipe in hours (based on... vessel regardless of the presence of secondary containment; plus (2) The discharge from all piping...

33 CFR 154.1029 - Worst case discharge.

Code of Federal Regulations, 2011 CFR

2011-07-01

... facility. The discharge from each pipe is calculated as follows: The maximum time to discover the release from the pipe in hours, plus the maximum time to shut down flow from the pipe in hours (based on... vessel regardless of the presence of secondary containment; plus (2) The discharge from all piping...

33 CFR 154.1029 - Worst case discharge.

Code of Federal Regulations, 2012 CFR

2012-07-01

... facility. The discharge from each pipe is calculated as follows: The maximum time to discover the release from the pipe in hours, plus the maximum time to shut down flow from the pipe in hours (based on... vessel regardless of the presence of secondary containment; plus (2) The discharge from all piping...

33 CFR 154.1029 - Worst case discharge.

Code of Federal Regulations, 2013 CFR

2013-07-01

... facility. The discharge from each pipe is calculated as follows: The maximum time to discover the release from the pipe in hours, plus the maximum time to shut down flow from the pipe in hours (based on... vessel regardless of the presence of secondary containment; plus (2) The discharge from all piping...

33 CFR 154.1029 - Worst case discharge.

Code of Federal Regulations, 2014 CFR

2014-07-01

... facility. The discharge from each pipe is calculated as follows: The maximum time to discover the release from the pipe in hours, plus the maximum time to shut down flow from the pipe in hours (based on... vessel regardless of the presence of secondary containment; plus (2) The discharge from all piping...

33 CFR 155.1230 - Response plan development and evaluation criteria.

Code of Federal Regulations, 2013 CFR

2013-07-01

... VESSELS Response plan requirements for vessels carrying animal fats and vegetable oils as a primary cargo... carry animal fats or vegetable oils as a primary cargo must provide information in their plan that identifies— (1) Procedures and strategies for responding to a worst case discharge of animal fats or...

33 CFR 155.1230 - Response plan development and evaluation criteria.

Code of Federal Regulations, 2014 CFR

2014-07-01

... VESSELS Response plan requirements for vessels carrying animal fats and vegetable oils as a primary cargo... carry animal fats or vegetable oils as a primary cargo must provide information in their plan that identifies— (1) Procedures and strategies for responding to a worst case discharge of animal fats or...

33 CFR 155.1230 - Response plan development and evaluation criteria.

Code of Federal Regulations, 2012 CFR

2012-07-01

... VESSELS Response plan requirements for vessels carrying animal fats and vegetable oils as a primary cargo... carry animal fats or vegetable oils as a primary cargo must provide information in their plan that identifies— (1) Procedures and strategies for responding to a worst case discharge of animal fats or...

Competitive Strategies and Financial Performance of Small Colleges

ERIC Educational Resources Information Center

Barron, Thomas A., Jr.

2017-01-01

Many institutions of higher education are facing significant financial challenges, resulting in diminished economic viability and, in the worst cases, the threat of closure (Moody's Investor Services, 2015). The study was designed to explore the effectiveness of competitive strategies for small colleges in terms of financial performance. Five…

40 CFR 63.11980 - What are the test methods and calculation procedures for process wastewater?

Code of Federal Regulations, 2013 CFR

2013-07-01

... calculation procedures for process wastewater? 63.11980 Section 63.11980 Protection of Environment... § 63.11980 What are the test methods and calculation procedures for process wastewater? (a) Performance... performance tests during worst-case operating conditions for the PVCPU when the process wastewater treatment...

40 CFR 63.11980 - What are the test methods and calculation procedures for process wastewater?

Code of Federal Regulations, 2012 CFR

2012-07-01

... calculation procedures for process wastewater? 63.11980 Section 63.11980 Protection of Environment... § 63.11980 What are the test methods and calculation procedures for process wastewater? (a) Performance... performance tests during worst-case operating conditions for the PVCPU when the process wastewater treatment...

40 CFR 63.11980 - What are the test methods and calculation procedures for process wastewater?

Code of Federal Regulations, 2014 CFR

2014-07-01

... calculation procedures for process wastewater? 63.11980 Section 63.11980 Protection of Environment... § 63.11980 What are the test methods and calculation procedures for process wastewater? (a) Performance... performance tests during worst-case operating conditions for the PVCPU when the process wastewater treatment...

30 CFR 254.21 - How must I format my response plan?

Code of Federal Regulations, 2010 CFR

2010-07-01

... divide your response plan for OCS facilities into the sections specified in paragraph (b) and explained in the other sections of this subpart. The plan must have an easily found marker identifying each.... (ii) Contractual agreements. (iii) Worst case discharge scenario. (iv) Dispersant use plan. (v) In...

Safety in the Chemical Laboratory: Laboratory Air Quality: Part I. A Concentration Model.

ERIC Educational Resources Information Center

Butcher, Samuel S.; And Others

1985-01-01

Offers a simple model for estimating vapor concentrations in instructional laboratories. Three methods are described for measuring ventilation rates, and the results of measurements in six laboratories are presented. The model should provide a simple screening tool for evaluating worst-case personal exposures. (JN)

A Didactic Analysis of Functional Queues

ERIC Educational Resources Information Center

Rinderknecht, Christian

2011-01-01

When first introduced to the analysis of algorithms, students are taught how to assess the best and worst cases, whereas the mean and amortized costs are considered advanced topics, usually saved for graduates. When presenting the latter, aggregate analysis is explained first because it is the most intuitive kind of amortized analysis, often…

Genetically modified crops and aquatic ecosystems: considerations for environmental risk assessment and non-target organism testing.

PubMed

Carstens, Keri; Anderson, Jennifer; Bachman, Pamela; De Schrijver, Adinda; Dively, Galen; Federici, Brian; Hamer, Mick; Gielkens, Marco; Jensen, Peter; Lamp, William; Rauschen, Stefan; Ridley, Geoff; Romeis, Jörg; Waggoner, Annabel

2012-08-01

Environmental risk assessments (ERA) support regulatory decisions for the commercial cultivation of genetically modified (GM) crops. The ERA for terrestrial agroecosystems is well-developed, whereas guidance for ERA of GM crops in aquatic ecosystems is not as well-defined. The purpose of this document is to demonstrate how comprehensive problem formulation can be used to develop a conceptual model and to identify potential exposure pathways, using Bacillus thuringiensis (Bt) maize as a case study. Within problem formulation, the insecticidal trait, the crop, the receiving environment, and protection goals were characterized, and a conceptual model was developed to identify routes through which aquatic organisms may be exposed to insecticidal proteins in maize tissue. Following a tiered approach for exposure assessment, worst-case exposures were estimated using standardized models, and factors mitigating exposure were described. Based on exposure estimates, shredders were identified as the functional group most likely to be exposed to insecticidal proteins. However, even using worst-case assumptions, the exposure of shredders to Bt maize was low and studies supporting the current risk assessments were deemed adequate. Determining if early tier toxicity studies are necessary to inform the risk assessment for a specific GM crop should be done on a case by case basis, and should be guided by thorough problem formulation and exposure assessment. The processes used to develop the Bt maize case study are intended to serve as a model for performing risk assessments on future traits and crops.

Uncertainty Quantification for Ice Sheet Science and Sea Level Projections

NASA Astrophysics Data System (ADS)

Boening, C.; Schlegel, N.; Limonadi, D.; Schodlok, M.; Seroussi, H. L.; Larour, E. Y.; Watkins, M. M.

2017-12-01

In order to better quantify uncertainties in global mean sea level rise projections and in particular upper bounds, we aim at systematically evaluating the contributions from ice sheets and potential for extreme sea level rise due to sudden ice mass loss. Here, we take advantage of established uncertainty quantification tools embedded within the Ice Sheet System Model (ISSM) as well as sensitivities to ice/ocean interactions using melt rates and melt potential derived from MITgcm/ECCO2. With the use of these tools, we conduct Monte-Carlo style sampling experiments on forward simulations of the Antarctic ice sheet, by varying internal parameters and boundary conditions of the system over both extreme and credible worst-case ranges. Uncertainty bounds for climate forcing are informed by CMIP5 ensemble precipitation and ice melt estimates for year 2100, and uncertainty bounds for ocean melt rates are derived from a suite of regional sensitivity experiments using MITgcm. Resulting statistics allow us to assess how regional uncertainty in various parameters affect model estimates of century-scale sea level rise projections. The results inform efforts to a) isolate the processes and inputs that are most responsible for determining ice sheet contribution to sea level; b) redefine uncertainty brackets for century-scale projections; and c) provide a prioritized list of measurements, along with quantitative information on spatial and temporal resolution, required for reducing uncertainty in future sea level rise projections. Results indicate that ice sheet mass loss is dependent on the spatial resolution of key boundary conditions - such as bedrock topography and melt rates at the ice-ocean interface. This work is performed at and supported by the California Institute of Technology's Jet Propulsion Laboratory. Supercomputing time is also supported through a contract with the National Aeronautics and Space Administration's Cryosphere program.

Lessons Learned from Real-Time, Event-Based Internet Science Communications

NASA Technical Reports Server (NTRS)

Phillips, T.; Myszka, E.; Gallagher, D. L.; Adams, M. L.; Koczor, R. J.; Whitaker, Ann F. (Technical Monitor)

2001-01-01

For the last several years the Science Directorate at Marshall Space Flight Center has carried out a diverse program of Internet-based science communication. The Directorate's Science Roundtable includes active researchers, NASA public relations, educators, and administrators. The Science@NASA award-winning family of Web sites features science, mathematics, and space news. The program includes extended stories about NASA science, a curriculum resource for teachers tied to national education standards, on-line activities for students, and webcasts of real-time events. The focus of sharing science activities in real-time has been to involve and excite students and the public about science. Events have involved meteor showers, solar eclipses, natural very low frequency radio emissions, and amateur balloon flights. In some cases, broadcasts accommodate active feedback and questions from Internet participants. Through these projects a pattern has emerged in the level of interest or popularity with the public. The pattern differentiates projects that include science from those that do not, All real-time, event-based Internet activities have captured public interest at a level not achieved through science stories or educator resource material exclusively. The worst event-based activity attracted more interest than the best written science story. One truly rewarding lesson learned through these projects is that the public recognizes the importance and excitement of being part of scientific discovery. Flying a camera to 100,000 feet altitude isn't as interesting to the public as searching for viable life-forms at these oxygen-poor altitudes. The details of these real-time, event-based projects and lessons learned will be discussed.

Tissue Engineering Initiative

DTIC Science & Technology

2000-08-01

forefoot with the foot in the neutral position, and (b) similar to (a) but with heel landing. Although the authors reported no absolute strain values...diameter of sensors (or, in the case of a rectangular sensor, width as measured along pin axis). Worst case : Strike line from inside edges of sensors...potoroo it is just prior to "toe strike ". The locomotion of the potoroo is described as digitigrade, unlike humans, who walk in a plantigrade manner

Space Based Intelligence, Surveillance, and Reconnaissance Contribution to Global Strike in 2035

DTIC Science & Technology

2012-02-15

include using high altitude air platforms and airships as a short-term solution, and small satellites with an Operationally Responsive Space (ORS) launch...irreversible threats, along with a worst case scenario. Section IV provides greater detail of the high altitude air platform, airship , and commercial space...Resultantly, the U.S. could use high altitude air platforms, airships , and cyber to complement its space systems in case of denial, degradation, or

Assess the flood resilience tools integration in the landuse projects

NASA Astrophysics Data System (ADS)

Moulin, E.; Deroubaix, J.-F.

2012-04-01

Despite a severe regulation concerning the building in flooding areas, 80% of these areas are already built in the Greater Paris (Paris, Val-de-Marne, Hauts-de-Seine and Seine-Saint-Denis). The land use in flooding area is presented as one of the main solutions to solve the ongoing real estate pressure. For instance some of the industrial wastelands located along the river are currently in redevelopment and residential buildings are planned. So the landuse in the flooding areas is currently a key issue in the development of the Greater Paris area. To deal with floods there are some resilience tools, whether structural (such as perimeter barriers or building aperture barriers, etc) or non structural (such as warning systems, etc.). The technical solutions are available and most of the time efficient1. Still, we notice that these tools are not much implemented. The people; stakeholders and inhabitants, literally seems to be not interested. This papers focus on the integration of resilience tools in urban projects. Indeed one of the blockages in the implementation of an efficient flood risk prevention policy is the lack of concern of the landuse stakeholders and the inhabitants for the risk2. We conducted an important number of interviews with stakeholders involved in various urban projects and we assess, in this communication, to what extent the improvement of the resilience to floods is considered as a main issue in the execution of an urban project? How this concern is maintained or could be maintained throughout the project. Is there a dilution of this concern? In order to develop this topic we rely on a case study. The "Ardoines" is a project aiming at redeveloping an industrial site (South-East Paris), into a project including residential and office buildings and other amenities. In order to elaborate the master plan, the urban planning authority brought together some flood risk experts. According to the comments of the experts, the architect in charge of the landuse elaborated the master plan taking into account the flood risk; reducing vulnerability of the area and improving the resilience in case of floods, towards a threshold plan. We set this case-study back in the French policy context of prevention and protection against floods and in the context of the Greater Paris development. There are two levels of problems: In the case of the Ardoines project, the reduction of vulnerability isn't linked with the improvement of the resilience. Indeed, the stakeholders do not envisage an event worst than the 100-years flood return period, the one taken into account in a flood prevention plan. The regulation is the guide for construction rules but there is no consideration for the crisis management. Moreover, the reduction of vulnerability appears less important than the economical issues in the management of a project. This case study illustrates how the lack of awareness for territorial resilience issues and the lack of interest for flood resilience tools are embedded in the "governance" of the risk in the greater Paris area.

Managing in a New Reality

ERIC Educational Resources Information Center

Goldstein, Philip J.

2009-01-01

The phrase "worst since the Great Depression" has seemingly punctuated every economic report. The United States is experiencing the worst housing market, the worst unemployment level, and the worst drop in gross domestic product since the Great Depression. Although the steady drumbeat of bad news may have made everyone nearly numb, one…

Tsunami vulnerability and damage assessment in the coastal area of Rabat and Salé, Morocco

NASA Astrophysics Data System (ADS)

Atillah, A.; El Hadani, D.; Moudni, H.; Lesne, O.; Renou, C.; Mangin, A.; Rouffi, F.

2011-12-01

This study, a companion paper to Renou et al. (2011), focuses on the application of a GIS-based method to assess building vulnerability and damage in the event of a tsunami affecting the coastal area of Rabat and Salé, Morocco. This approach, designed within the framework of the European SCHEMA project (www.schemaproject.org) is based on the combination of hazard results from numerical modelling of the worst case tsunami scenario (inundation depth) based on the historical Lisbon earthquake of 1755 and the Portugal earthquake of 1969, together with vulnerability building types derived from Earth Observation data, field surveys and GIS data. The risk is then evaluated for this highly concentrated population area characterized by the implementation of a vast project of residential and touristic buildings within the flat area of the Bouregreg Valley separating the cities of Rabat and Salé. A GIS tool is used to derive building damage maps by crossing layers of inundation levels and building vulnerability. The inferred damage maps serve as a base for elaborating evacuation plans with appropriate rescue and relief processes and to prepare and consider appropriate measures to prevent the induced tsunami risk.

The lionfish Pterois sp. invasion: Has the worst-case scenario come to pass?

PubMed

Côté, I M; Smith, N S

2018-03-01

This review revisits the traits thought to have contributed to the success of Indo-Pacific lionfish Pterois sp. as an invader in the western Atlantic Ocean and the worst-case scenario about their potential ecological effects in light of the more than 150 studies conducted in the past 5 years. Fast somatic growth, resistance to parasites, effective anti-predator defences and an ability to circumvent predator recognition mechanisms by prey have probably contributed to rapid population increases of lionfish in the invaded range. However, evidence that lionfish are strong competitors is still ambiguous, in part because demonstrating competition is challenging. Geographic spread has likely been facilitated by the remarkable capacity of lionfish for prolonged fasting in combination with other broad physiological tolerances. Lionfish have had a large detrimental effect on native reef-fish populations in the northern part of the invaded range, but similar effects have yet to be seen in the southern Caribbean. Most other envisaged direct and indirect consequences of lionfish predation and competition, even those that might have been expected to occur rapidly, such as shifts in benthic composition, have yet to be realized. Lionfish populations in some of the first areas invaded have started to decline, perhaps as a result of resource depletion or ongoing fishing and culling, so there is hope that these areas have already experienced the worst of the invasion. In closing, we place lionfish in a broader context and argue that it can serve as a new model to test some fundamental questions in invasion ecology. © 2018 The Fisheries Society of the British Isles.

Costs and cost-effectiveness of 9-valent human papillomavirus (HPV) vaccination in two East African countries.

PubMed

Kiatpongsan, Sorapop; Kim, Jane J

2014-01-01

Current prophylactic vaccines against human papillomavirus (HPV) target two of the most oncogenic types, HPV-16 and -18, which contribute to roughly 70% of cervical cancers worldwide. Second-generation HPV vaccines include a 9-valent vaccine, which targets five additional oncogenic HPV types (i.e., 31, 33, 45, 52, and 58) that contribute to another 15-30% of cervical cancer cases. The objective of this study was to determine a range of vaccine costs for which the 9-valent vaccine would be cost-effective in comparison to the current vaccines in two less developed countries (i.e., Kenya and Uganda). The analysis was performed using a natural history disease simulation model of HPV and cervical cancer. The mathematical model simulates individual women from an early age and tracks health events and resource use as they transition through clinically-relevant health states over their lifetime. Epidemiological data on HPV prevalence and cancer incidence were used to adapt the model to Kenya and Uganda. Health benefit, or effectiveness, from HPV vaccination was measured in terms of life expectancy, and costs were measured in international dollars (I$). The incremental cost of the 9-valent vaccine included the added cost of the vaccine counterbalanced by costs averted from additional cancer cases prevented. All future costs and health benefits were discounted at an annual rate of 3% in the base case analysis. We conducted sensitivity analyses to investigate how infection with multiple HPV types, unidentifiable HPV types in cancer cases, and cross-protection against non-vaccine types could affect the potential cost range of the 9-valent vaccine. In the base case analysis in Kenya, we found that vaccination with the 9-valent vaccine was very cost-effective (i.e., had an incremental cost-effectiveness ratio below per-capita GDP), compared to the current vaccines provided the added cost of the 9-valent vaccine did not exceed I$9.7 per vaccinated girl. To be considered very cost-effective, the added cost per vaccinated girl could go up to I$5.2 and I$16.2 in the worst-case and best-case scenarios, respectively. At a willingness-to-pay threshold of three times per-capita GDP where the 9-valent vaccine would be considered cost-effective, the thresholds of added costs associated with the 9-valent vaccine were I$27.3, I$14.5 and I$45.3 per vaccinated girl for the base case, worst-case and best-case scenarios, respectively. In Uganda, vaccination with the 9-valent vaccine was very cost-effective when the added cost of the 9-valent vaccine did not exceed I$8.3 per vaccinated girl. To be considered very cost-effective, the added cost per vaccinated girl could go up to I$4.5 and I$13.7 in the worst-case and best-case scenarios, respectively. At a willingness-to-pay threshold of three times per-capita GDP, the thresholds of added costs associated with the 9-valent vaccine were I$23.4, I$12.6 and I$38.4 per vaccinated girl for the base case, worst-case and best-case scenarios, respectively. This study provides a threshold range of incremental costs associated with the 9-valent HPV vaccine that would make it a cost-effective intervention in comparison to currently available HPV vaccines in Kenya and Uganda. These prices represent a 71% and 61% increase over the price offered to the GAVI Alliance ($5 per dose) for the currently available 2- and 4-valent vaccines in Kenya and Uganda, respectively. Despite evidence of cost-effectiveness, critical challenges around affordability and feasibility of HPV vaccination and other competing needs in low-resource settings such as Kenya and Uganda remain.

Costs and Cost-Effectiveness of 9-Valent Human Papillomavirus (HPV) Vaccination in Two East African Countries

PubMed Central

Kiatpongsan, Sorapop; Kim, Jane J.

2014-01-01

Background Current prophylactic vaccines against human papillomavirus (HPV) target two of the most oncogenic types, HPV-16 and -18, which contribute to roughly 70% of cervical cancers worldwide. Second-generation HPV vaccines include a 9-valent vaccine, which targets five additional oncogenic HPV types (i.e., 31, 33, 45, 52, and 58) that contribute to another 15–30% of cervical cancer cases. The objective of this study was to determine a range of vaccine costs for which the 9-valent vaccine would be cost-effective in comparison to the current vaccines in two less developed countries (i.e., Kenya and Uganda). Methods and Findings The analysis was performed using a natural history disease simulation model of HPV and cervical cancer. The mathematical model simulates individual women from an early age and tracks health events and resource use as they transition through clinically-relevant health states over their lifetime. Epidemiological data on HPV prevalence and cancer incidence were used to adapt the model to Kenya and Uganda. Health benefit, or effectiveness, from HPV vaccination was measured in terms of life expectancy, and costs were measured in international dollars (I$). The incremental cost of the 9-valent vaccine included the added cost of the vaccine counterbalanced by costs averted from additional cancer cases prevented. All future costs and health benefits were discounted at an annual rate of 3% in the base case analysis. We conducted sensitivity analyses to investigate how infection with multiple HPV types, unidentifiable HPV types in cancer cases, and cross-protection against non-vaccine types could affect the potential cost range of the 9-valent vaccine. In the base case analysis in Kenya, we found that vaccination with the 9-valent vaccine was very cost-effective (i.e., had an incremental cost-effectiveness ratio below per-capita GDP), compared to the current vaccines provided the added cost of the 9-valent vaccine did not exceed I$9.7 per vaccinated girl. To be considered very cost-effective, the added cost per vaccinated girl could go up to I$5.2 and I$16.2 in the worst-case and best-case scenarios, respectively. At a willingness-to-pay threshold of three times per-capita GDP where the 9-valent vaccine would be considered cost-effective, the thresholds of added costs associated with the 9-valent vaccine were I$27.3, I$14.5 and I$45.3 per vaccinated girl for the base case, worst-case and best-case scenarios, respectively. In Uganda, vaccination with the 9-valent vaccine was very cost-effective when the added cost of the 9-valent vaccine did not exceed I$8.3 per vaccinated girl. To be considered very cost-effective, the added cost per vaccinated girl could go up to I$4.5 and I$13.7 in the worst-case and best-case scenarios, respectively. At a willingness-to-pay threshold of three times per-capita GDP, the thresholds of added costs associated with the 9-valent vaccine were I$23.4, I$12.6 and I$38.4 per vaccinated girl for the base case, worst-case and best-case scenarios, respectively. Conclusions This study provides a threshold range of incremental costs associated with the 9-valent HPV vaccine that would make it a cost-effective intervention in comparison to currently available HPV vaccines in Kenya and Uganda. These prices represent a 71% and 61% increase over the price offered to the GAVI Alliance ($5 per dose) for the currently available 2- and 4-valent vaccines in Kenya and Uganda, respectively. Despite evidence of cost-effectiveness, critical challenges around affordability and feasibility of HPV vaccination and other competing needs in low-resource settings such as Kenya and Uganda remain. PMID:25198104

Astronomy for teachers: A South African Perspective

NASA Astrophysics Data System (ADS)

de Witt, Aletha; West, Marion; Leeuw, Lerothodi; Gouws, Eldrie

2015-08-01

South Africa has nominated Astronomy as a “flagship science” and aims to be an international Astronomy hub through projects such as the Square Kilometre Array (SKA) and the South African Large Telescope (SALT). These projects open up career opportunities in maths, science and engineering and therefore offers a very real door for learners to enter into careers in science and technology through Astronomy. However, the Trends in International Mathematics and Science Survey (TIMSS), the Global Competitiveness Report (GCR) and Annual National Assessment (ANA) have highlighted that South Africa’s Science and Mathematics education is in a critical condition and that South African learners score amongst the worst in the world in both these subjects. In South Africa Astronomy is generally regarded as the worst taught and most avoided Natural Science knowledge strand, and most teachers that specialised in Natural Sciences, never covered Astronomy in their training.In order to address these issues a collaborative project between the University of South Africa (UNISA) and the Hartebeesthoek Radio Astronomy Observatory (HartRAO) was initiated, which aims to assist teachers to gain more knowledge and skills so that they can teach Astronomy with confidence. By collaborating we aim to ensure that the level of astronomy development will be raised in both South Africa and the rest of Africa.With the focus on Teaching and Learning, the research was conducted within a quantitative paradigm and 600 structured questionnaires were administered to Natural Science teachers in Public primary schools in Gauteng, South Africa. This paper reports the findings of this research and makes recommendations on how to assist teachers to teach Astronomy with confidence.

A Systematic Review Comparing the Acceptability, Validity and Concordance of Discrete Choice Experiments and Best-Worst Scaling for Eliciting Preferences in Healthcare.

PubMed

Whitty, Jennifer A; Oliveira Gonçalves, Ana Sofia

2018-06-01

The aim of this study was to compare the acceptability, validity and concordance of discrete choice experiment (DCE) and best-worst scaling (BWS) stated preference approaches in health. A systematic search of EMBASE, Medline, AMED, PubMed, CINAHL, Cochrane Library and EconLit databases was undertaken in October to December 2016 without date restriction. Studies were included if they were published in English, presented empirical data related to the administration or findings of traditional format DCE and object-, profile- or multiprofile-case BWS, and were related to health. Study quality was assessed using the PREFS checklist. Fourteen articles describing 12 studies were included, comparing DCE with profile-case BWS (9 studies), DCE and multiprofile-case BWS (1 study), and profile- and multiprofile-case BWS (2 studies). Although limited and inconsistent, the balance of evidence suggests that preferences derived from DCE and profile-case BWS may not be concordant, regardless of the decision context. Preferences estimated from DCE and multiprofile-case BWS may be concordant (single study). Profile- and multiprofile-case BWS appear more statistically efficient than DCE, but no evidence is available to suggest they have a greater response efficiency. Little evidence suggests superior validity for one format over another. Participant acceptability may favour DCE, which had a lower self-reported task difficulty and was preferred over profile-case BWS in a priority setting but not necessarily in other decision contexts. DCE and profile-case BWS may be of equal validity but give different preference estimates regardless of the health context; thus, they may be measuring different constructs. Therefore, choice between methods is likely to be based on normative considerations related to coherence with theoretical frameworks and on pragmatic considerations related to ease of data collection.

Current and future disease progression of the chronic HCV population in the United States.

PubMed

Zalesak, Martin; Francis, Kevin; Gedeon, Alex; Gillis, John; Hvidsten, Kyle; Kidder, Phyllis; Li, Hong; Martyn, Derek; Orne, Leslie; Smith, Amanda; Kwong, Ann

2013-01-01

Chronic hepatitis C virus (HCV) infection can lead to advanced liver disease (AdvLD), including cirrhosis, decompensated cirrhosis, and liver cancer. The aim of this study was to determine recent historical rates of HCV patient progression to AdvLD and to project AdvLD prevalence through 2015. We first determined total 2008 US chronic HCV prevalence from the National Health and Nutrition Evaluation Surveys. Next, we examined disease progression and associated non-pharmacological costs of diagnosed chronic HCV-infected patients between 2007-2009 in the IMS LifeLink and CMS Medicare claims databases. A projection model was developed to estimate AdvLD population growth through 2015 in patients diagnosed and undiagnosed as of 2008, using the 2007-2009 progression rates to generate a "worst case" projection of the HCV-related AdvLD population (i.e., scenario where HCV treatment is the same in the forecasted period as it was before 2009). We found that the total diagnosed chronic HCV population grew from 983,000 to 1.19 million in 2007-2009, with patients born from 1945-1964 accounting for 75.0% of all patients, 83.7% of AdvLD patients, and 79.2% of costs in 2009, indicating that HCV is primarily a disease of the "baby boomer" population. Non-pharmacological costs grew from $7.22 billion to $8.63 billion, with the majority of growth derived from the 60,000 new patients that developed AdvLD in 2007-2009, 91.5% of whom were born between 1945 and 1964. The projection model estimated the total AdvLD population would grow from 195,000 in 2008 to 601,000 in 2015, with 73.5% of new AdvLD cases from patients undiagnosed as of 2008. AdvLD prevalence in patients diagnosed as of 2008 was projected to grow 6.5% annually to 303,000 patients in 2015. These findings suggest that strategies to diagnose and treat HCV-infected patients are urgently needed to increase the likelihood that progression is interrupted, particularly for patients born from 1945-1964.

DSN human factors project

NASA Technical Reports Server (NTRS)

Chafin, R. L.; Martin, T. H.

1980-01-01

The project plan was to hold focus groups to identify the factors influencing the ease of use characteristics of software and to bond the problem. A questionnaire survey was conducted to evaluate those factors which were more appropriately measured with that method. The performance oriented factors were analyzed and relationships hypothesized. The hypotheses were put to test in the experimental phase of the project. In summary, the initial analysis indicates that there is an initial performance effect favoring computer controlled dialogue but the advantage fades fast as operators become experienced. The user documentation style is seen to have a significant effect on performance. The menu and prompt command formats are preferred by inexperienced operators. The short form mnemonic is least favored. There is no clear best command format but the short form mnemonic is clearly the worst.

Trauma and conditional risk of posttraumatic stress disorder in two American Indian reservation communities.

PubMed

Beals, Janette; Belcourt-Dittloff, Annjeanette; Garroutte, Eva M; Croy, Calvin; Jervis, Lori L; Whitesell, Nancy Rumbaugh; Mitchell, Christina M; Manson, Spero M

2013-06-01

To determine conditional risk of posttraumatic stress disorder (PTSD) in two culturally distinct American Indian reservation communities. Data derived from the American Indian Service Utilization, Psychiatric Epidemiology, Risk and Protective Factors Project, a cross-sectional population-based survey that was completed between 1997 and 2000. This study focused on 1,967 participants meeting the DSM-IV criteria for trauma exposure. Traumas were grouped into interpersonal, non-interpersonal, witnessed, and "trauma to close others" categories. Analyses examined distribution of worst traumas, conditional rates of PTSD following exposure, and distributions of PTSD cases deriving from these events. Bivariate and multivariate logistic regressions estimated associations of lifetime PTSD with trauma type. Overall, 15.9 % of those exposed to DSM-IV trauma qualified for lifetime PTSD, a rate comparable to similar US studies. Women were more likely to develop PTSD than were men. The majority (60 %) of cases of PTSD among women derived from interpersonal trauma exposure (in particular, sexual and physical abuse); among men, cases were more evenly distributed across trauma categories. Previous research has demonstrated higher rates of both trauma exposure and PTSD in American Indian samples compared to other Americans. This study shows that conditional rates of PTSD are similar to those reported elsewhere, suggesting that the elevated prevalence of this disorder in American Indian populations is largely due to higher rates of trauma exposure.

78 FR 53494 - Dam Safety Modifications at Cherokee, Fort Loudoun, Tellico, and Watts Bar Dams

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-29

... fundamental part of this mission was the construction and operation of an integrated system of dams and... by the Federal Emergency Management Agency, TVA prepares for the worst case flooding event in order... appropriate best management practices during all phases of construction and maintenance associated with the...

Task 1, Design Analysis Report: Pulsed plasma solid propellant microthruster for the synchronous meteorological satellite

NASA Technical Reports Server (NTRS)

Guman, W. J. (Editor)

1971-01-01

Thermal vacuum design supporting thruster tests indicate no problems under the worst case conditions of sink temperature and spin rate. The reliability of the system was calculated to be 0.92 for a five-year mission. Minus the main energy storage capacitor it is 0.98.

40 CFR 300.320 - General pattern of response.

Code of Federal Regulations, 2010 CFR

2010-07-01

...., substantial threat to the public health or welfare of the United States, worst case discharge) of the... private party efforts, and where the discharge does not pose a substantial threat to the public health or... 40 Protection of Environment 27 2010-07-01 2010-07-01 false General pattern of response. 300.320...

Small Wars 2.0: A Working Paper on Land Force Planning After Iraq and Afghanistan

DTIC Science & Technology

2011-02-01

official examination of future ground combat demands that look genetically distinct from those undertaken in the name of the WoT. The concept of...under the worst-case rubric but for very different reasons. The latter are small wars. However, that by no means aptly describes their size

The +vbar breakout during approach to Space Station Freedom

NASA Technical Reports Server (NTRS)

Dunham, Scott D.

1993-01-01

A set of burn profiles was developed to provide bounding jet firing histories for a +vbar breakout during approaches to Space Station Freedom. The delta-v sequences were designed to place the Orbiter on a safe trajectory under worst case conditions and to try to minimize plume impingement on Space Station Freedom structure.

A Comparison of Learning Technologies for Teaching Spacecraft Software Development

ERIC Educational Resources Information Center

Straub, Jeremy

2014-01-01

The development of software for spacecraft represents a particular challenge and is, in many ways, a worst case scenario from a design perspective. Spacecraft software must be "bulletproof" and operate for extended periods of time without user intervention. If the software fails, it cannot be manually serviced. Software failure may…

Providing Exemplars in the Learning Environment: The Case For and Against

ERIC Educational Resources Information Center

Newlyn, David

2013-01-01

Contemporary education has moved towards the requirement of express articulation of assessment criteria and standards in an attempt to provide legitimacy in the measurement of student performance/achievement. Exemplars are provided examples of best or worst practice in the educational environment, which are designed to assist students to increase…

Ageing of Insensitive DNAN Based Melt-Cast Explosives

DTIC Science & Technology

2014-08-01

diurnal cycle (representative of the MEAO climate). Analysis of the ingredient composition, sensitiveness, mechanical and thermal properties was...first test condition was chosen to provide a worst-case scenario. Analysis of the ingredient composition, theoretical maximum density, sensitiveness...5 4.1.1 ARX-4027 Ingredient Analysis .............................................................. 5 4.1.2 ARX-4028 Ingredient Analysis

Power Analysis for Anticipated Non-Response in Randomized Block Designs

ERIC Educational Resources Information Center

Pustejovsky, James E.

2011-01-01

Recent guidance on the treatment of missing data in experiments advocates the use of sensitivity analysis and worst-case bounds analysis for addressing non-ignorable missing data mechanisms; moreover, plans for the analysis of missing data should be specified prior to data collection (Puma et al., 2009). While these authors recommend only that…

33 CFR 154.1120 - Operating restrictions and interim operating authorization.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) Facility Operating in Prince William Sound, Alaska § 154.1120 Operating restrictions and interim operating authorization. (a) The owner or operator of a TAPAA facility may not operate in Prince William Sound, Alaska... practicable, a worst case discharge or a discharge of 200,000 barrels of oil, whichever is grater, in Prince...

Facilitating Interdisciplinary Work: Using Quality Assessment to Create Common Ground

ERIC Educational Resources Information Center

Oberg, Gunilla

2009-01-01

Newcomers often underestimate the challenges of interdisciplinary work and, as a rule, do not spend sufficient time to allow them to overcome differences and create common ground, which in turn leads to frustration, unresolved conflicts, and, in the worst case scenario, discontinued work. The key to successful collaboration is to facilitate the…

76 FR 34799 - Permanent Dam Safety Modification at Cherokee, Fort Loudoun, Tellico, and Watts Bar Dams, TN

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-14

... notice is provided in accordance with the Council on Environmental Quality's regulations (40 CFR parts... interconnected, fabric-lined, sand-filled HESCO containers in order to safely pass predicted worst-case..., but will not necessarily be limited to, the potential impacts on water quality, aquatic and...

Mixed-Age Grouping in Kindergarten: A Best Case Example of Developmentally Appropriate Practice or Horace Mann's Worst Nightmare?

ERIC Educational Resources Information Center

Tercek, Patricia M.

This practicum study examined kindergarten teachers' perspectives regarding mixed-age groupings that included kindergarten students. The study focused on pedagogical reasons for using mixed-age grouping, ingredients necessary for successful implementation of a multiage program that includes kindergartners, and the perceived effects of a multiage…

Case Study: POLYTECH High School, Woodside, Delaware.

ERIC Educational Resources Information Center

Southern Regional Education Board, Atlanta, GA.

POLYTECH High School in Woodside, Delaware, has gone from being among the worst schools in the High Schools That Work (HSTW) network to among the best. Polytech, which is now a full-time technical high school, has improved its programs and outcomes by implementing a series of organizational, curriculum, teaching, guidance, and leadership changes,…

Guide for Oxygen Component Qualification Tests

NASA Technical Reports Server (NTRS)

Bamford, Larry J.; Rucker, Michelle A.; Dobbin, Douglas

1996-01-01

Although oxygen is a chemically stable element, it is not shock sensitive, will not decompose, and is not flammable. Oxygen use therefore carries a risk that should never be overlooked, because oxygen is a strong oxidizer that vigorously supports combustion. Safety is of primary concern in oxygen service. To promote safety in oxygen systems, the flammability of materials used in them should be analyzed. At the NASA White Sands Test Facility (WSTF), we have performed configurational tests of components specifically engineered for oxygen service. These tests follow a detailed WSTF oxygen hazards analysis. The stated objective of the tests was to provide performance test data for customer use as part of a qualification plan for a particular component in a particular configuration, and under worst-case conditions. In this document - the 'Guide for Oxygen Component Qualification Tests' - we outline recommended test systems, and cleaning, handling, and test procedures that address worst-case conditions. It should be noted that test results apply specifically to: manual valves, remotely operated valves, check valves, relief valves, filters, regulators, flexible hoses, and intensifiers. Component systems are not covered.

The impact of the fast ion fluxes and thermal plasma loads on the design of the ITER fast ion loss detector

NASA Astrophysics Data System (ADS)

Kocan, M.; Garcia-Munoz, M.; Ayllon-Guerola, J.; Bertalot, L.; Bonnet, Y.; Casal, N.; Galdon, J.; Garcia-Lopez, J.; Giacomin, T.; Gonzalez-Martin, J.; Gunn, J. P.; Rodriguez-Ramos, M.; Reichle, R.; Rivero-Rodriguez, J. F.; Sanchis-Sanchez, L.; Vayakis, G.; Veshchev, E.; Vorpahl, C.; Walsh, M.; Walton, R.

2017-12-01

Thermal plasma loads to the ITER Fast Ion Loss Detector are studied for QDT = 10 burning plasma equilibrium using the 3D field line tracing. The simulations are performed for a FILD insertion 9-13 cm past the port plasma facing surface, optimized for fast ion measurements, and include the worst-case perturbation of the plasma boundary and the error in the magnetic reconstruction. The FILD head is exposed to superimposed time-averaged ELM heat load, static inter-ELM heat flux and plasma radiation. The study includes the estimate of the instantaneous temperature rise due to individual 0.6 MJ controlled ELMs. The maximum time-averaged surface heat load is lesssim 12 MW/m2 and will lead to increase of the FILD surface temperature well below the melting temperature of the materials considered here, for the FILD insertion time of 0.2 s. The worst-case instantaneous temperature rise during controlled 0.6 MJ ELMs is also significantly smaller than the melting temperature of e.g. Tungsten or Molybdenum, foreseen for the FILD housing.

Virtual sensors for active noise control in acoustic-structural coupled enclosures using structural sensing: robust virtual sensor design.

PubMed

Halim, Dunant; Cheng, Li; Su, Zhongqing

2011-03-01

The work was aimed to develop a robust virtual sensing design methodology for sensing and active control applications of vibro-acoustic systems. The proposed virtual sensor was designed to estimate a broadband acoustic interior sound pressure using structural sensors, with robustness against certain dynamic uncertainties occurring in an acoustic-structural coupled enclosure. A convex combination of Kalman sub-filters was used during the design, accommodating different sets of perturbed dynamic model of the vibro-acoustic enclosure. A minimax optimization problem was set up to determine an optimal convex combination of Kalman sub-filters, ensuring an optimal worst-case virtual sensing performance. The virtual sensing and active noise control performance was numerically investigated on a rectangular panel-cavity system. It was demonstrated that the proposed virtual sensor could accurately estimate the interior sound pressure, particularly the one dominated by cavity-controlled modes, by using a structural sensor. With such a virtual sensing technique, effective active noise control performance was also obtained even for the worst-case dynamics. © 2011 Acoustical Society of America

Evaluating predictors of lead exposure for activities disturbing materials painted with or containing lead using historic published data from U.S. workplaces.

PubMed

Locke, Sarah J; Deziel, Nicole C; Koh, Dong-Hee; Graubard, Barry I; Purdue, Mark P; Friesen, Melissa C

2017-02-01

We evaluated predictors of differences in published occupational lead concentrations for activities disturbing material painted with or containing lead in U.S. workplaces to aid historical exposure reconstruction. For the aforementioned tasks, 221 air and 113 blood lead summary results (1960-2010) were extracted from a previously developed database. Differences in the natural log-transformed geometric mean (GM) for year, industry, job, and other ancillary variables were evaluated in meta-regression models that weighted each summary result by its inverse variance and sample size. Air and blood lead GMs declined 5%/year and 6%/year, respectively, in most industries. Exposure contrast in the GMs across the nine jobs and five industries was higher based on air versus blood concentrations. For welding activities, blood lead GMs were 1.7 times higher in worst-case versus non-worst case scenarios. Job, industry, and time-specific exposure differences were identified; other determinants were too sparse or collinear to characterize. Am. J. Ind. Med. 60:189-197, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

A radiation briefer's guide to the PIKE Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steadman, Jr, C R

1990-03-01

Gamma-radiation-exposure estimates to populations living immediately downwind from the Nevada Test Site have been required for many years by the US Department of Energy (DOE) before each containment-designed nuclear detonation. A highly unlikely worst-case'' scenario is utilized which assumes that there will be an accidental massive venting of radioactive debris into the atmosphere shortly after detonation. The Weather Service Nuclear Support Office (WSNSO) has supplied DOE with such estimates for the last 25 years using the WSNSO Fallout Scaling Technique (FOST), which employs a worst-case analog event that actually occurred in the past. The PIKE Model'' is the application ofmore » the FOST using the PIKE nuclear event as the analog. This report, which is primarily intended for WSNSO meteorologists who derive radiation estimates, gives a brief history of the model,'' presents the mathematical, radiological, and meteorological concepts upon which it is based, states its limitations, explains it apparent advantages over more sophisticated models, and details how it is used operationally. 10 refs., 31 figs., 7 tabs.« less

Housing for the "Worst of the Worst" Inmates: Public Support for Supermax Prisons

ERIC Educational Resources Information Center

Mears, Daniel P.; Mancini, Christina; Beaver, Kevin M.; Gertz, Marc

2013-01-01

Despite concerns whether supermaximum security prisons violate human rights or prove effective, these facilities have proliferated in America over the past 25 years. This punishment--aimed at the "worst of the worst" inmates and involving 23-hr-per-day single-cell confinement with few privileges or services--has emerged despite little…

Opposite latitudinal gradients in projected ocean acidification and bleaching impacts on coral reefs.

PubMed

van Hooidonk, Ruben; Maynard, Jeffrey Allen; Manzello, Derek; Planes, Serge

2014-01-01

Coral reefs and the services they provide are seriously threatened by ocean acidification and climate change impacts like coral bleaching. Here, we present updated global projections for these key threats to coral reefs based on ensembles of IPCC AR5 climate models using the new Representative Concentration Pathway (RCP) experiments. For all tropical reef locations, we project absolute and percentage changes in aragonite saturation state (Ωarag) for the period between 2006 and the onset of annual severe bleaching (thermal stress >8 degree heating weeks); a point at which it is difficult to believe reefs can persist as we know them. Severe annual bleaching is projected to start 10-15 years later at high-latitude reefs than for reefs in low latitudes under RCP8.5. In these 10-15 years, Ωarag keeps declining and thus any benefits for high-latitude reefs of later onset of annual bleaching may be negated by the effects of acidification. There are no long-term refugia from the effects of both acidification and bleaching. Of all reef locations, 90% are projected to experience severe bleaching annually by 2055. Furthermore, 5% declines in calcification are projected for all reef locations by 2034 under RCP8.5, assuming a 15% decline in calcification per unit of Ωarag. Drastic emissions cuts, such as those represented by RCP6.0, result in an average year for the onset of annual severe bleaching that is ~20 years later (2062 vs. 2044). However, global emissions are tracking above the current worst-case scenario devised by the scientific community, as has happened in previous generations of emission scenarios. The projections here for conditions on coral reefs are dire, but provide the most up-to-date assessment of what the changing climate and ocean acidification mean for the persistence of coral reefs. © 2013 John Wiley & Sons Ltd.

Hydraulic Fracturing of Soils; A Literature Review.

DTIC Science & Technology

1977-03-01

best case, or worst case. The study reported herein is an overview of one such test or technique, hydraulic fracturing , which is defined as the...formation of cracks, in soil by the application of hydraulic pressure greater than the minor principal stress at that point. Hydraulic fracturing , as a... hydraulic fracturing as a means for determination of lateral stresses, the technique can still be used for determining in situ total stress and permeability at a point in a cohesive soil.

Health risk impacts analysis of fugitive aromatic compounds emissions from the working face of a municipal solid waste landfill in China.

PubMed

Liu, Yanjun; Liu, Yanting; Li, Hao; Fu, Xindi; Guo, Hanwen; Meng, Ruihong; Lu, Wenjing; Zhao, Ming; Wang, Hongtao

2016-12-01

Aromatic compounds (ACs) emitted from landfills have attracted a lot of attention of the public due to their adverse impacts on the environment and human health. This study assessed the health risk impacts of the fugitive ACs emitted from the working face of a municipal solid waste (MSW) landfill in China. The emission data was acquired by long-term in-situ samplings using a modified wind tunnel system. The uncertainty of aromatic emissions is determined by means of statistics and the emission factors were thus developed. Two scenarios, i.e. 'normal-case' and 'worst-case', were presented to evaluate the potential health risk in different weather conditions. For this typical large anaerobic landfill, toluene was the dominant species owing to its highest releasing rate (3.40±3.79g·m -2 ·d -1 ). Despite being of negligible non-carcinogenic risk, the ACs might bring carcinogenic risks to human in the nearby area. Ethylbenzene was the major health threat substance. The cumulative carcinogenic risk impact area is as far as ~1.5km at downwind direction for the normal-case scenario, and even nearly 4km for the worst-case scenario. Health risks of fugitive ACs emissions from active landfills should be concerned, especially for landfills which still receiving mixed MSW. Copyright © 2016 Elsevier Ltd. All rights reserved.

"Best Case/Worst Case": Qualitative Evaluation of a Novel Communication Tool for Difficult in-the-Moment Surgical Decisions.

PubMed

Kruser, Jacqueline M; Nabozny, Michael J; Steffens, Nicole M; Brasel, Karen J; Campbell, Toby C; Gaines, Martha E; Schwarze, Margaret L

2015-09-01

To evaluate a communication tool called "Best Case/Worst Case" (BC/WC) based on an established conceptual model of shared decision-making. Focus group study. Older adults (four focus groups) and surgeons (two focus groups) using modified questions from the Decision Aid Acceptability Scale and the Decisional Conflict Scale to evaluate and revise the communication tool. Individuals aged 60 and older recruited from senior centers (n = 37) and surgeons from academic and private practices in Wisconsin (n = 17). Qualitative content analysis was used to explore themes and concepts that focus group respondents identified. Seniors and surgeons praised the tool for the unambiguous illustration of multiple treatment options and the clarity gained from presentation of an array of treatment outcomes. Participants noted that the tool provides an opportunity for in-the-moment, preference-based deliberation about options and a platform for further discussion with other clinicians and loved ones. Older adults worried that the format of the tool was not universally accessible for people with different educational backgrounds, and surgeons had concerns that the tool was vulnerable to physicians' subjective biases. The BC/WC tool is a novel decision support intervention that may help facilitate difficult decision-making for older adults and their physicians when considering invasive, acute medical treatments such as surgery. © 2015, Copyright the Authors Journal compilation © 2015, The American Geriatrics Society.

Primary Spinal Cord Melanoma: A Case Report and a Systemic Review of Overall Survival.

PubMed

Zhang, Mingzhe; Liu, Raynald; Xiang, Yi; Mao, Jianhui; Li, Guangjie; Ma, Ronghua; Sun, Zhaosheng

2018-06-01

The incidence of primary spinal cord melanoma (PSCM) is rare. Several case series and case reports have been published in the literature. However, the predictive factors of PSCM survival and management options are not discussed in detail. We present a case of PSCM; total resection was achieved and chemotherapy was given postoperatively. A comprehensive search was performed on PubMed's electronic database using the words "primary spinal cord melanoma." Survival rates with various gender, location, treatment, and metastasis condition were collected from the published articles and analyzed. Fifty nine cases were eligible for the survival analysis; 54% were male and 46% were female. Patient sex did not influence overall survival. The most common location was the thorax. Patient sex and tumor location did not influence overall survival. The major presenting symptoms were weakness and paresthesia of the extremities. Metastasis or dissemination was noted in 45.16% of 31 patients. In the Kaplan-Meier survival analysis, patients who had metastasis had the worst prognosis. Extent of resection was not related to mortality. Patients who received surgery and surgery with adjuvant therapy had a better median survival than did those who had adjuvant therapy alone. Prognosis was worst in those patients who underwent only adjuvant therapy without surgery (5 months). Surgery is the first treatment of choice in treating PSCM. The goal of tumor resection is to reduce symptoms. Adjuvant therapy after surgery had a beneficial effect on limiting the metastasis. Copyright © 2018 Elsevier Inc. All rights reserved.

Estimated intake of the artificial sweeteners acesulfame-K, aspartame, cyclamate and saccharin in a group of Swedish diabetics.

PubMed

Ilbäck, N-G; Alzin, M; Jahrl, S; Enghardt-Barbieri, H; Busk, L

2003-02-01

Few sweetener intake studies have been performed on the general population and only one study has been specifically designed to investigate diabetics and children. This report describes a Swedish study on the estimated intake of the artificial sweeteners acesulfame-K, aspartame, cyclamate and saccharin by children (0-15 years) and adult male and female diabetics (types I and II) of various ages (16-90 years). Altogether, 1120 participants were asked to complete a questionnaire about their sweetener intake. The response rate (71%, range 59-78%) was comparable across age and gender groups. The most consumed 'light' foodstuffs were diet soda, cider, fruit syrup, table powder, table tablets, table drops, ice cream, chewing gum, throat lozenges, sweets, yoghurt and vitamin C. The major sources of sweetener intake were beverages and table powder. About 70% of the participants, equally distributed across all age groups, read the manufacturer's specifications of the food products' content. The estimated intakes showed that neither men nor women exceeded the ADI for acesulfame-K; however, using worst-case calculations, high intakes were found in young children (169% of ADI). In general, the aspartame intake was low. Children had the highest estimated (worst case) intake of cyclamate (317% of ADI). Children's estimated intake of saccharin only slightly exceeded the ADI at the 5% level for fruit syrup. Children had an unexpected high intake of tabletop sweeteners, which, in Sweden, is normally based on cyclamate. The study was performed during two winter months when it can be assumed that the intake of sweeteners was lower as compared with during warm, summer months. Thus, the present study probably underestimates the average intake on a yearly basis. However, our worst-case calculations based on maximum permitted levels were performed on each individual sweetener, although exposure is probably relatively evenly distributed among all sweeteners, except for cyclamate containing table sweeteners.

Dispelling urban myths about default uncertainty factors in chemical risk assessment – sufficient protection against mixture effects?

PubMed Central

2013-01-01

Assessing the detrimental health effects of chemicals requires the extrapolation of experimental data in animals to human populations. This is achieved by applying a default uncertainty factor of 100 to doses not found to be associated with observable effects in laboratory animals. It is commonly assumed that the toxicokinetic and toxicodynamic sub-components of this default uncertainty factor represent worst-case scenarios and that the multiplication of those components yields conservative estimates of safe levels for humans. It is sometimes claimed that this conservatism also offers adequate protection from mixture effects. By analysing the evolution of uncertainty factors from a historical perspective, we expose that the default factor and its sub-components are intended to represent adequate rather than worst-case scenarios. The intention of using assessment factors for mixture effects was abandoned thirty years ago. It is also often ignored that the conservatism (or otherwise) of uncertainty factors can only be considered in relation to a defined level of protection. A protection equivalent to an effect magnitude of 0.001-0.0001% over background incidence is generally considered acceptable. However, it is impossible to say whether this level of protection is in fact realised with the tolerable doses that are derived by employing uncertainty factors. Accordingly, it is difficult to assess whether uncertainty factors overestimate or underestimate the sensitivity differences in human populations. It is also often not appreciated that the outcome of probabilistic approaches to the multiplication of sub-factors is dependent on the choice of probability distributions. Therefore, the idea that default uncertainty factors are overly conservative worst-case scenarios which can account both for the lack of statistical power in animal experiments and protect against potential mixture effects is ill-founded. We contend that precautionary regulation should provide an incentive to generate better data and recommend adopting a pragmatic, but scientifically better founded approach to mixture risk assessment. PMID:23816180

Dispelling urban myths about default uncertainty factors in chemical risk assessment--sufficient protection against mixture effects?

PubMed

Martin, Olwenn V; Martin, Scholze; Kortenkamp, Andreas

2013-07-01

Assessing the detrimental health effects of chemicals requires the extrapolation of experimental data in animals to human populations. This is achieved by applying a default uncertainty factor of 100 to doses not found to be associated with observable effects in laboratory animals. It is commonly assumed that the toxicokinetic and toxicodynamic sub-components of this default uncertainty factor represent worst-case scenarios and that the multiplication of those components yields conservative estimates of safe levels for humans. It is sometimes claimed that this conservatism also offers adequate protection from mixture effects. By analysing the evolution of uncertainty factors from a historical perspective, we expose that the default factor and its sub-components are intended to represent adequate rather than worst-case scenarios. The intention of using assessment factors for mixture effects was abandoned thirty years ago. It is also often ignored that the conservatism (or otherwise) of uncertainty factors can only be considered in relation to a defined level of protection. A protection equivalent to an effect magnitude of 0.001-0.0001% over background incidence is generally considered acceptable. However, it is impossible to say whether this level of protection is in fact realised with the tolerable doses that are derived by employing uncertainty factors. Accordingly, it is difficult to assess whether uncertainty factors overestimate or underestimate the sensitivity differences in human populations. It is also often not appreciated that the outcome of probabilistic approaches to the multiplication of sub-factors is dependent on the choice of probability distributions. Therefore, the idea that default uncertainty factors are overly conservative worst-case scenarios which can account both for the lack of statistical power in animal experiments and protect against potential mixture effects is ill-founded. We contend that precautionary regulation should provide an incentive to generate better data and recommend adopting a pragmatic, but scientifically better founded approach to mixture risk assessment.

Assessing oral bioaccessibility of trace elements in soils under worst-case scenarios by automated in-line dynamic extraction as a front end to inductively coupled plasma atomic emission spectrometry.

PubMed

Rosende, María; Magalhães, Luis M; Segundo, Marcela A; Miró, Manuel

2014-09-09

A novel biomimetic extraction procedure that allows for the in-line handing of ≥400 mg solid substrates is herein proposed for automatic ascertainment of trace element (TE) bioaccessibility in soils under worst-case conditions as per recommendations of ISO norms. A unified bioaccessibility/BARGE method (UBM)-like physiological-based extraction test is evaluated for the first time in a dynamic format for accurate assessment of in-vitro bioaccessibility of Cr, Cu, Ni, Pb and Zn in forest and residential-garden soils by on-line coupling of a hybrid flow set-up to inductively coupled plasma atomic emission spectrometry. Three biologically relevant operational extraction modes mimicking: (i) gastric juice extraction alone; (ii) saliva and gastric juice composite in unidirectional flow extraction format and (iii) saliva and gastric juice composite in a recirculation mode were thoroughly investigated. The extraction profiles of the three configurations using digestive fluids were proven to fit a first order reaction kinetic model for estimating the maximum TE bioaccessibility, that is, the actual worst-case scenario in human risk assessment protocols. A full factorial design, in which the sample amount (400-800 mg), the extractant flow rate (0.5-1.5 mL min(-1)) and the extraction temperature (27-37°C) were selected as variables for the multivariate optimization studies in order to obtain the maximum TE extractability. Two soils of varied physicochemical properties were analysed and no significant differences were found at the 0.05 significance level between the summation of leached concentrations of TE in gastric juice plus the residual fraction and the total concentration of the overall assayed metals determined by microwave digestion. These results showed the reliability and lack of bias (trueness) of the automatic biomimetic extraction approach using digestive juices. Copyright © 2014 Elsevier B.V. All rights reserved.

Relaxing USOS Solar Array Constraints for Russian Vehicle Undocking

NASA Technical Reports Server (NTRS)

Menkin, Evgeny; Schrock, Mariusz; Schrock, Rita; Zaczek, Mariusz; Gomez, Susan; Lee, Roscoe; Bennet, George

2011-01-01

With the retirement of Space Shuttle cargo delivery capability and the ten year life extension of the International Space Station (ISS) more emphasis is being put on preservation of the service life of ISS critical components. Current restrictions on the United States Orbital Segment (USOS) Solar Array (SA) positioning during Russian Vehicle (RV) departure from ISS nadir and zenith ports cause SA to be positioned in the plume field of Service Module thrusters and lead to degradation of SAs as well as potential damage to Sun tracking Beta Gimbal Assemblies (BGA). These restrictions are imposed because of the single fault tolerant RV Motion Control System (MCS), which does not meet ISS Safety requirements for catastrophic hazards and dictates 16 degree Solar Array Rotary Joint position, which ensures that ISS and RV relative motion post separation, does lead to collision. The purpose of this paper is to describe a methodology and the analysis that was performed to determine relative motion trajectories of the ISS and separating RV for nominal and contingency cases. Analysis was performed in three phases that included ISS free drift prior to Visiting Vehicle separation, ISS and Visiting Vehicle relative motion analysis and clearance analysis. First, the ISS free drift analysis determined the worst case attitude and attitude rate excursions prior to RV separation based on a series of different configurations and mass properties. Next, the relative motion analysis calculated the separation trajectories while varying the initial conditions, such as docking mechanism performance, Visiting Vehicle MCS failure, departure port location, ISS attitude and attitude rates at the time of separation, etc. The analysis employed both orbital mechanics and rigid body rotation calculations while accounting for various atmospheric conditions and gravity gradient effects. The resulting relative motion trajectories were then used to determine the worst case separation envelopes during the clearance analysis. Analytical models were developed individually for each stage and the results were used to build initial conditions for the following stages. In addition to the analysis approach, this paper also discusses the analysis results, showing worst case relative motion envelopes, the recommendations for ISS appendage positioning and the suggested approach for future analyses.

Modelling Long Term Disability following Injury: Comparison of Three Approaches for Handling Multiple Injuries

PubMed Central

Gabbe, Belinda J.; Harrison, James E.; Lyons, Ronan A.; Jolley, Damien

2011-01-01

Background Injury is a leading cause of the global burden of disease (GBD). Estimates of non-fatal injury burden have been limited by a paucity of empirical outcomes data. This study aimed to (i) establish the 12-month disability associated with each GBD 2010 injury health state, and (ii) compare approaches to modelling the impact of multiple injury health states on disability as measured by the Glasgow Outcome Scale – Extended (GOS-E). Methods 12-month functional outcomes for 11,337 survivors to hospital discharge were drawn from the Victorian State Trauma Registry and the Victorian Orthopaedic Trauma Outcomes Registry. ICD-10 diagnosis codes were mapped to the GBD 2010 injury health states. Cases with a GOS-E score >6 were defined as “recovered.” A split dataset approach was used. Cases were randomly assigned to development or test datasets. Probability of recovery for each health state was calculated using the development dataset. Three logistic regression models were evaluated: a) additive, multivariable; b) “worst injury;” and c) multiplicative. Models were adjusted for age and comorbidity and investigated for discrimination and calibration. Findings A single injury health state was recorded for 46% of cases (1–16 health states per case). The additive (C-statistic 0.70, 95% CI: 0.69, 0.71) and “worst injury” (C-statistic 0.70; 95% CI: 0.68, 0.71) models demonstrated higher discrimination than the multiplicative (C-statistic 0.68; 95% CI: 0.67, 0.70) model. The additive and “worst injury” models demonstrated acceptable calibration. Conclusions The majority of patients survived with persisting disability at 12-months, highlighting the importance of improving estimates of non-fatal injury burden. Additive and “worst” injury models performed similarly. GBD 2010 injury states were moderately predictive of recovery 1-year post-injury. Further evaluation using additional measures of health status and functioning and comparison with the GBD 2010 disability weights will be needed to optimise injury states for future GBD studies. PMID:21984951

Tsunamis from Tectonic Sources along Caribbean Plate Boundaries

NASA Astrophysics Data System (ADS)

Lopez, A. M.; Chacon, S.; Zamora, N.; Audemard, F. A.; Dondin, F. J. Y.; Clouard, V.; Løvholt, F.; Harbitz, C. B.; Vanacore, E. A.; Huerfano Moreno, V. A.

2015-12-01

The Working Group 2 (WG2) of the Intergovernmental Coordination Group for the Tsunami and Other Coastal Hazards Warning System for the Caribbean and Adjacent Regions (ICG/CARIBE-EWS) in charge of Tsunami Hazards Assessment, has generated a list of tsunami sources for the Caribbean region. Simulating these worst-case, most credible scenarios would provide an estimate of the resulting effects on coastal areas within the Caribbean. In the past few years, several publications have addressed this issue resulting in a collection of potential tsunami sources and scenarios. These publications come from a wide variety of sources; from government agencies to academic institutions. Although these provide the scientific community with a list of sources and scenarios, it was the interest of the WG2 to evaluate what has been proposed and develop a comprehensive list of sources, therefore leaving aside proposed scenarios. The seismo-tectonics experts of the Caribbean within the WG2 members were tasked to evaluate comprehensively which published sources are credible, worst-cases, and consider other sources that have been omitted from available reports. Among these published sources are the GEM Faulted Earth Subduction Characterization Project, and the LANTEX/Caribe Wave annual exercise publications (2009-2015). Caribbean tectonic features capable of generating tsunamis from seismic dislocation are located along the Northeastern Caribbean, the Lesser Antilles Trench, and the Panamá and Southern Caribbean Deformed Belts. The proposed sources have been evaluated based on historical and instrumental seismicity as well as geological and geophysical studies. This paper presents the sources and their justification as most-probable tsunami sources based on the context of crustal deformation due to Caribbean plate interacting with neighboring North and South America plates. Simulations of these sources is part of a subsequent phase in which effects of these tectonically induced tsunamis are evaluated in the near-field, and wave history snapshots are used to estimate arrival times and coastal effects at other locations within the Caribbean basin. This study is part of a contribution of the WG2 of ICG/CARIBE-EWS to UNESCO's Intergovernmental Oceanographic Commission.

Tail mean and related robust solution concepts

NASA Astrophysics Data System (ADS)

Ogryczak, Włodzimierz

2014-01-01

Robust optimisation might be viewed as a multicriteria optimisation problem where objectives correspond to the scenarios although their probabilities are unknown or imprecise. The simplest robust solution concept represents a conservative approach focused on the worst-case scenario results optimisation. A softer concept allows one to optimise the tail mean thus combining performances under multiple worst scenarios. We show that while considering robust models allowing the probabilities to vary only within given intervals, the tail mean represents the robust solution for only upper bounded probabilities. For any arbitrary intervals of probabilities the corresponding robust solution may be expressed by the optimisation of appropriately combined mean and tail mean criteria thus remaining easily implementable with auxiliary linear inequalities. Moreover, we use the tail mean concept to develope linear programming implementable robust solution concepts related to risk averse optimisation criteria.

Cyber-security Considerations for Real-Time Physiological Status Monitoring: Threats, Goals, and Use Cases

DTIC Science & Technology

2016-11-01

low- power RF transmissions used by the OBAN system. B. Threat Analysis Methodology To analyze the risk presented by a particular threat we use a... power efficiency5 and in the absolute worst case a compromise of the wireless channel could result in death. Fitness trackers on the other hand are...analysis is intended to inform the development of secure RT-PSM architectures. I. INTRODUCTION The development of very low- power computing devices and

Considering the worst-case metabolic scenario, but training to the typical-case competitive scenario: response to Amtmann (2012).

PubMed

Del Vecchio, Fabrício Boscolo; Franchini, Emerson

2013-08-01

This response to Amtmann's letter emphasizes that the knowledge of the typical time structure, as well as its variation, together with the main goal of the mixed martial arts athletes--to win by knock out or submission--need to be properly considered during the training sessions. Example with other combat sports are given and discussed, especially concerning the importance of adapting the physical conditioning workouts to the technical-tactical profile of the athlete and not the opposite.

The reduction of a ""safety catastrophic'' potential hazard: A case history

NASA Technical Reports Server (NTRS)

Jones, J. P.

1971-01-01

A worst case analysis is reported on the safety of time watch movements for triggering explosive packages on the lunar surface in an experiment to investigate physical lunar structural characteristics through induced seismic energy waves. Considered are the combined effects of low pressure, low temperature, lunar gravity, gear train error, and position. Control measures constitute a seal control cavity and design requirements to prevent overbanking in the mainspring torque curve. Thus, the potential hazard is reduced to safety negligible.

Indigenous traditional medicine and intercultural healthcare in Bolivia: a case study from the Potosi region.

PubMed

Torri, Maria Costanza; Hollenberg, Daniel

2013-01-01

Indigenous peoples have the worst socio-demographic indicators and the largest inequalities in terms of access to social services and health in the Latin American region, Bolivia included. In the last few years, attempts to implement policies that support indigenous people's health rights led to the development of intercultural health approaches. Yet, acceptance and integration of indigenous medicine into the biomedical health system presents a major challenge to intercultural health in Latin America. The objective of this article is to analyze the case of a health center in Tinguipaya, one of the first and few examples of intercultural health initiatives in Bolivia. This intercultural health project, which represents a pioneer experience with regard to the creation of intercultural health services in Bolivia, aims to create a network between local communities, traditional healers, and biomedical staff and offer a more culturally sensitive and holistic health service for indigenous people living in the area. The aim of this article is to critically assess this initiative and to analyze the main challenges met in the creation of a more effective intercultural health policy. The extent to which this initiative succeeded in promoting the integration between indigenous health practitioners and biomedical staff as well as in improving access to health care for local indigenous patients will also be examined.

Using a Historical Lens to Envision the Next Generation of Genomic Translation Research.

PubMed

McBride, Colleen M; Abrams, Leah R; Koehly, Laura M

2015-01-01

The past 20 years have witnessed successive and exponential advances in genomic discovery and technology, with a broad scientific imperative pushing for continual advancements. The most consistent critique of these advances is that they have vastly outpaced translation of new knowledge into improvements in public health and medicine. We employ a historical and epistemological analysis to characterize how prevailing scientific meta-narratives have shaped the pace and priorities of research applying genomics to health promotion. We use four 'pivotal events' - the genetic characterization of Down syndrome, the launch of the Human Genome Research Project, the discovery of BRCA1, and the emergence of direct-to- consumer genetic testing - to illustrate how these scientific meta-narratives have inhibited genomic translation research. The notion that discovery should precede translation research has over-focused translation research on the latest genetic testing platform. The idea that genetic-related research has an exceptional potential for public harm has encouraged research on worst case scenarios. The perceived competition between genetics and social determinants of health has discouraged a unified research agenda to move genomic translation forward. We make a case for creating new scientific meta-narratives in which discovery and translation research agendas are envisioned as an interdependent enterprise. © 2015 S. Karger AG, Basel.

Small hydropower plants standardization, between myth and reality

NASA Astrophysics Data System (ADS)

Paraschivescu, A. V.; Ahmad-Rashid, K.; Popa, F.; Popa, B.

2017-01-01

Many providers for small hydropower plants equipment have tried to standardize the components and even the entire equipment. So called “compact turbines” were launched on the market, ensuring the pre-designed solution of the modular components, but usually with lower efficiency then turbines specially designed for a certain site. For civil works it is possible to standardize some components, such as the powerhouse, the surge tank or the headrace, but not the intake and the weir. Part of the hydropower plants can be standardized, but not the entire project, because there are a lot of variables that influence the design. Among these, the dimension, materials and design of the canal and the penstock are given by the hydrology, topography and the geology of the project’s area. This paper presents an attempt at standardization by using different heads and different installed flows. The case study is made on the Lukosi River from Tanzania, because there is a good hydrological database on power and energy calculation. For the powerhouse, pressure tower and intake dimensioning, the assumptions and materials considered cover all challenges that could appear in the geological and topographical structure of the project’s area (worst case, most expensive). The study has highlighted African climatologic and hydrological conditions and the adapting of current technology to these conditions.

33 CFR 154.1035 - Specific requirements for facilities that could reasonably be expected to cause significant and...

Code of Federal Regulations, 2011 CFR

2011-07-01

... spill mitigation procedures. (i) This subsection must describe the volume(s) and oil groups that would... applicable, the worst case discharge from the non-transportation-related facility. This must be the same volume provided in the response plan for the non-transportation-related facility. (ii) This subsection...

Effects of forcing uncertainties in the improvement skills of assimilating satellite soil moisture retrievals into flood forecasting models

USDA-ARS?s Scientific Manuscript database

Floods have negative impacts on society, causing damages in infrastructures and industry, and in the worst cases, causing loss of human lives. Thus early and accurate warning is crucial to significantly reduce the impacts on public safety and economy. Reliable flood warning can be generated using ...

Evaluation of Bias Correction Methods for "Worst-case" Selective Non-participation in NAEP

ERIC Educational Resources Information Center

McLaughlin, Don; Gallagher, Larry; Stancavage, Fran

2004-01-01

With the advent of No Child Left Behind (NCLB), the context for NAEP participation is changing. Whereas in the past participation in NAEP has always been voluntary, participation is now mandatory for some grade and subjects among schools receiving Title I funds. While this will certainly raise school-level participation rates in the mandated…

30 CFR 254.26 - What information must I include in the “Worst case discharge scenario” appendix?

Code of Federal Regulations, 2012 CFR

2012-07-01

... ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.26... the facility that oil could move in a time period that it reasonably could be expected to persist in...

30 CFR 254.26 - What information must I include in the “Worst case discharge scenario” appendix?

Code of Federal Regulations, 2014 CFR

2014-07-01

... ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.26... the facility that oil could move in a time period that it reasonably could be expected to persist in...

30 CFR 254.26 - What information must I include in the “Worst case discharge scenario” appendix?

Code of Federal Regulations, 2013 CFR

2013-07-01

... ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.26... the facility that oil could move in a time period that it reasonably could be expected to persist in...

40 CFR 57.405 - Formulation, approval, and implementation of requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... study shall be submitted after the end of the worst case three-month period as a part of the next semi... study demonstrating that the SCS will prevent violations of the NAAQS in the smelter's DLA at all times. The reliability study shall include a comprehensive analysis of the system's operation during one or...

Algorithm Diversity for Resilent Systems

DTIC Science & Technology

2016-06-27

data structures. 15. SUBJECT TERMS computer security, software diversity, program transformation 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF 18...systematic method for transforming Datalog rules with general universal and existential quantification into efficient algorithms with precise complexity...worst case in the size of the ground rules. There are numerous choices during the transformation that lead to diverse algorithms and different

CTE Delivers Leaders

ERIC Educational Resources Information Center

Magnuson, Peter

2013-01-01

Imagine a football team without a quarterback. Imagine a ship without a captain. Imagine a kitchen without a chef. Right now, you are probably running a number of worst-case scenarios through your head: a losing season; a ship adrift; some not-so-tasty cookies. The reason your mind has conjured up these end results is because in each of these…

The Mayors' Charter Schools

ERIC Educational Resources Information Center

Magee, Michael

2014-01-01

In 2007, the case could be made that Rhode Island had, dollar for dollar, the worst-performing public education system in the United States. Despite per-pupil expenditures ranking in the top 10 nationally, the state's 8th graders fared no better than 40th in reading and 33rd in math on the National Assessment of Educational Progress (NAEP). Only…

Improved Multiple-Species Cyclotron Ion Source

NASA Technical Reports Server (NTRS)

Soli, George A.; Nichols, Donald K.

1990-01-01

Use of pure isotope 86Kr instead of natural krypton in multiple-species ion source enables source to produce krypton ions separated from argon ions by tuning cylcotron with which source used. Addition of capability to produce and separate krypton ions at kinetic energies of 150 to 400 MeV necessary for simulation of worst-case ions occurring in outer space.

Analyzing Uncertainty and Risk in the Management of Water Resources in the State Of Texas

NASA Astrophysics Data System (ADS)

Singh, A.; Hauffpauir, R.; Mishra, S.; Lavenue, M.

2010-12-01

The State of Texas updates its state water plan every five years to determine the water demand required to meet its growing population. The plan compiles forecasts of water deficits from state-wide regional water planning groups as well as the water supply strategies to address these deficits. To date, the plan has adopted a deterministic framework, where reference values (e.g., best estimates, worst-case scenario) are used for key factors such as population growth, demand for water, severity of drought, water availability, etc. These key factors can, however, be affected by multiple sources of uncertainties such as - the impact of climate on surface water and groundwater availability, uncertainty in population projections, changes in sectoral composition of the economy, variability in water usage, feasibility of the permitting process, cost of implementation, etc. The objective of this study was to develop a generalized and scalable methodology for addressing uncertainty and risk in water resources management both at the regional and the local water planning level. The study proposes a framework defining the elements of an end-to-end system model that captures the key components of demand, supply and planning modules along with their associated uncertainties. The framework preserves the fundamental elements of the well-established planning process in the State of Texas, promoting an incremental and stakeholder-driven approach to adding different levels of uncertainty (and risk) into the decision-making environment. The uncertainty in the water planning process is broken down into two primary categories: demand uncertainty and supply uncertainty. Uncertainty in Demand is related to the uncertainty in population projections and the per-capita usage rates. Uncertainty in Supply, in turn, is dominated by the uncertainty in future climate conditions. Climate is represented in terms of time series of precipitation, temperature and/or surface evaporation flux for some future time period of interest, which can be obtained as outputs of global climate models (GCMs). These are then linked with hydrologic and water-availability models (WAMs) to estimate water availability for the worst drought conditions under each future climate scenario. Combining the demand scenarios with the water availability scenarios yields multiple scenarios for water shortage (or surplus). Given multiple shortage/surplus scenarios, various water management strategies can be assessed to evaluate the reliability of meeting projected deficits. These reliabilities are then used within a multi-criteria decision-framework to assess trade-offs between various water management objectives, thus helping to make more robust decisions while planning for the water needs of the future.

Best-worst scaling to assess the most important barriers and facilitators for the use of health technology assessment in Austria.

PubMed

Feig, Chiara; Cheung, Kei Long; Hiligsmann, Mickaël; Evers, Silvia M A A; Simon, Judit; Mayer, Susanne

2018-04-01

Although Health Technology Assessment (HTA) is increasingly used to support evidence-based decision-making in health care, several barriers and facilitators for the use of HTA have been identified. This best-worst scaling (BWS) study aims to assess the relative importance of selected barriers and facilitators of the uptake of HTA studies in Austria. A BWS object case survey was conducted among 37 experts in Austria to assess the relative importance of HTA barriers and facilitators. Hierarchical Bayes estimation was applied, with the best-worst count analysis as sensitivity analysis. Subgroup analyses were also performed on professional role and HTA experience. The most important barriers were 'lack of transparency in the decision-making process', 'fragmentation', 'absence of appropriate incentives', 'no explicit framework for decision-making process', and 'insufficient legal support'. The most important facilitators were 'transparency in the decision-making process', 'availability of relevant HTA research for policy makers', 'availability of explicit framework for decision-making process', 'sufficient legal support', and 'appropriate incentives'. This study suggests that HTA barriers and facilitators related to the context of decision makers, especially 'policy characteristics' and 'organization and resources' are the most important in Austria. A transparent and participatory decision-making process could improve the adoption of HTA evidence.

Use of Medicare claims to rank hospitals by surgical site infection risk following coronary artery bypass graft surgery.

PubMed

Huang, Susan S; Placzek, Hilary; Livingston, James; Ma, Allen; Onufrak, Fallon; Lankiewicz, Julie; Kleinman, Ken; Bratzler, Dale; Olsen, Margaret A; Lyles, Rosie; Khan, Yosef; Wright, Paula; Yokoe, Deborah S; Fraser, Victoria J; Weinstein, Robert A; Stevenson, Kurt; Hooper, David; Vostok, Johanna; Datta, Rupak; Nsa, Wato; Platt, Richard

2011-08-01

To evaluate whether longitudinal insurer claims data allow reliable identification of elevated hospital surgical site infection (SSI) rates. We conducted a retrospective cohort study of Medicare beneficiaries who underwent coronary artery bypass grafting (CABG) in US hospitals performing at least 80 procedures in 2005. Hospitals were assigned to deciles by using case mix-adjusted probabilities of having an SSI-related inpatient or outpatient claim code within 60 days of surgery. We then reviewed medical records of randomly selected patients to assess whether chart-confirmed SSI risk was higher in hospitals in the worst deciles compared with the best deciles. Fee-for-service Medicare beneficiaries who underwent CABG in these hospitals in 2005. We evaluated 114,673 patients who underwent CABG in 671 hospitals. In the best decile, 7.8% (958/12,307) of patients had an SSI-related code, compared with 24.8% (2,747/11,068) in the worst decile ([Formula: see text]). Medical record review confirmed SSI in 40% (388/980) of those with SSI-related codes. In the best decile, the chart-confirmed annual SSI rate was 3.2%, compared with 9.4% in the worst decile, with an adjusted odds ratio of SSI of 2.7 (confidence interval, 2.2-3.3; [Formula: see text]) for CABG performed in a worst-decile hospital compared with a best-decile hospital. Claims data can identify groups of hospitals with unusually high or low post-CABG SSI rates. Assessment of claims is more reproducible and efficient than current surveillance methods. This example of secondary use of routinely recorded electronic health information to assess quality of care can identify hospitals that may benefit from prevention programs.

Case series: Two cases of eyeball tattoos with short-term complications.

PubMed

Duarte, Gonzalo; Cheja, Rashel; Pachón, Diana; Ramírez, Carolina; Arellanes, Lourdes

2017-04-01

To report two cases of eyeball tattoos with short-term post procedural complications. Case 1 is a 26-year-old Mexican man that developed orbital cellulitis and posterior scleritis 2 h after an eyeball tattoo. Patient responded satisfactorily to systemic antibiotic and corticosteroid treatment. Case 2 is a 17-year-old Mexican man that developed two sub-episcleral nodules in the ink injection sites immediately after the procedure. Eyeball tattoos are performed by non-ophthalmic trained personnel. There are a substantial number of short-term risks associated with this procedure. Long-term effects on the eyes and vision are still unknown, but in a worst case scenario could include loss of vision or permanent damage to the eyes.

Modelling of occupational respirable crystalline silica exposure for quantitative exposure assessment in community-based case-control studies.

PubMed

Peters, Susan; Vermeulen, Roel; Portengen, Lützen; Olsson, Ann; Kendzia, Benjamin; Vincent, Raymond; Savary, Barbara; Lavoué, Jérôme; Cavallo, Domenico; Cattaneo, Andrea; Mirabelli, Dario; Plato, Nils; Fevotte, Joelle; Pesch, Beate; Brüning, Thomas; Straif, Kurt; Kromhout, Hans

2011-11-01

We describe an empirical model for exposure to respirable crystalline silica (RCS) to create a quantitative job-exposure matrix (JEM) for community-based studies. Personal measurements of exposure to RCS from Europe and Canada were obtained for exposure modelling. A mixed-effects model was elaborated, with region/country and job titles as random effect terms. The fixed effect terms included year of measurement, measurement strategy (representative or worst-case), sampling duration (minutes) and a priori exposure intensity rating for each job from an independently developed JEM (none, low, high). 23,640 personal RCS exposure measurements, covering a time period from 1976 to 2009, were available for modelling. The model indicated an overall downward time trend in RCS exposure levels of -6% per year. Exposure levels were higher in the UK and Canada, and lower in Northern Europe and Germany. Worst-case sampling was associated with higher reported exposure levels and an increase in sampling duration was associated with lower reported exposure levels. Highest predicted RCS exposure levels in the reference year (1998) were for chimney bricklayers (geometric mean 0.11 mg m(-3)), monument carvers and other stone cutters and carvers (0.10 mg m(-3)). The resulting model enables us to predict time-, job-, and region/country-specific exposure levels of RCS. These predictions will be used in the SYNERGY study, an ongoing pooled multinational community-based case-control study on lung cancer.

A randomised controlled trial of three or one breathing technique training sessions for breathlessness in people with malignant lung disease.

PubMed

Johnson, Miriam J; Kanaan, Mona; Richardson, Gerry; Nabb, Samantha; Torgerson, David; English, Anne; Barton, Rachael; Booth, Sara

2015-09-07

About 90 % of patients with intra-thoracic malignancy experience breathlessness. Breathing training is helpful, but it is unknown whether repeated sessions are needed. The present study aims to test whether three sessions are better than one for breathlessness in this population. This is a multi-centre randomised controlled non-blinded parallel arm trial. Participants were allocated to three sessions or single (1:2 ratio) using central computer-generated block randomisation by an independent Trials Unit and stratified for centre. The setting was respiratory, oncology or palliative care clinics at eight UK centres. Inclusion criteria were people with intrathoracic cancer and refractory breathlessness, expected prognosis ≥3 months, and no prior experience of breathing training. The trial intervention was a complex breathlessness intervention (breathing training, anxiety management, relaxation, pacing, and prioritisation) delivered over three hour-long sessions at weekly intervals, or during a single hour-long session. The main primary outcome was worst breathlessness over the previous 24 hours ('worst'), by numerical rating scale (0 = none; 10 = worst imaginable). Our primary analysis was area under the curve (AUC) 'worst' from baseline to 4 weeks. All analyses were by intention to treat. Between April 2011 and October 2013, 156 consenting participants were randomised (52 three; 104 single). Overall, the 'worst' score reduced from 6.81 (SD, 1.89) to 5.84 (2.39). Primary analysis [n = 124 (79 %)], showed no between-arm difference in the AUC: three sessions 22.86 (7.12) vs single session 22.58 (7.10); P value = 0.83); mean difference 0.2, 95 % CIs (-2.31 to 2.97). Complete case analysis showed a non-significant reduction in QALYs with three sessions (mean difference -0.006, 95 % CIs -0.018 to 0.006). Sensitivity analyses found similar results. The probability of the single session being cost-effective (threshold value of £20,000 per QALY) was over 80 %. There was no evidence that three sessions conferred additional benefits, including cost-effectiveness, over one. A single session of breathing training seems appropriate and minimises patient burden. Registry: ISRCTN; ISRCTN49387307; http://www.isrctn.com/ISRCTN49387307 ; registration date: 25/01/2011.

Determination of the Changes of Drought Occurrence in Turkey Using Regional Climate Modeling

NASA Astrophysics Data System (ADS)

Sibel Saygili, Fatma; Tufan Turp, M.; Kurnaz, M. Levent

2017-04-01

As a consequence of the negative impacts of climate change, Turkey, being a country in the Mediterranean Basin, is under a serious risk of increased drought conditions. In this study, it is aimed to determine and compare the spatial distributions of climatological drought probabilities for Turkey. For this purpose, by making use of Regional Climate Model (RegCM4.4) of the Abdus Salam International Centre for Theoretical Physics (ICTP), the outputs of the MPI-ESM-MR global climate model of the Max Planck Institute for Meteorology are downscaled to 50km for Turkey. To make the future projection over Turkey for the period of 2071-2100 with respect to the reference period of 1986-2005, the worst case emission pathway RCP8.5 is used. The Palmer Drought Severity Index (PDSI) values are computed and classified in accordance with the seven classifications of National Oceanic and Atmospheric Administration (NOAA). Finally, the spatial distribution maps showing the changes in drought probabilities over Turkey are obtained in order to see the impact of climate change on Turkey's drought patterns.

Hydrology of Fritchie Marsh, coastal Louisiana

USGS Publications Warehouse

Kuniansky, E.L.

1985-01-01

Fritchie Marsh, near Slidell, Louisiana, is being considered as a disposal site for sewage effluent. A two-dimensional, finite element, surface water modeling systems was used to solve the shallow water equations for flow. Factors affecting flow patterns are channel locations, inlets, outlets, islands, marsh vegetation, marsh geometry, stage of the West Pearl River, flooding over the lower Pearl River basin, gravity tides, wind-induced currents, and sewage discharge to the marsh. Four steady-state simulations were performed for two hydrologic events at two rates of sewage discharge. The events, near tide with no wind or rain and neap tide with a tide differential across the marsh, were selected as worst-case events for sewage effluent dispersion and were assumed as steady state events. Because inflows and outflows to the marsh are tidally affected, steady state simulations cannot fully define the hydraulic characteristics of the marsh for all hydrologic events. Model results and field data indicate that, during near tide with little or no rain, large parts of the marsh are stagnant; and sewage effluent, at existing and projected flows, has minimal effect on marsh flows. (USGS)

Low-to-high refractive index contrast transition (RICT) device for low loss polymer-based optical coupling

NASA Astrophysics Data System (ADS)

Calabretta, N.; Cooman, I. A.; Stabile, R.

2018-04-01

We propose for the first time a coupling device concept for passive low-loss optical coupling, which is compatible with the ‘generic’ indium phosphide (InP) multi-project-wafer manufacturing. A low-to-high vertical refractive index contrast transition InP waveguide is designed and tapered down to adiabatically couple light into a top polymer waveguide. The on-chip embedded polymer waveguide is engineered at the chip facets for offering refractive-index and spot-size-matching to silica fiber-arrays. Numerical analysis shows that coupling losses lower than 1.5 dB can be achieved for a TE-polarized light between the InP waveguide and the on-chip embedded polymer waveguide at 1550 nm wavelength. The performance is mainly limited by the difficulty to control single-mode operation. However, coupling losses lower than 1.9 dB can be achieved for a bandwidth as large as 200 nm. Moreover, the foreseen fabrication process steps are indicated, which are compatible with the ‘generic’ InP multi-project-wafer manufacturing. A fabrication error tolerance study is performed, indicating that fabrication errors occur only in 0.25 dB worst case excess losses, as long as high precision lithography is used. The obtained results are promising and may open the route to large port counts and cheap packaging of InP-based photonic integrated chips.

Technology readiness levels and technology status for selected long term/high payoff technologies on the RLV program

NASA Technical Reports Server (NTRS)

Rosmait, Russell L.

1996-01-01

The development of a new space transportation system in a climate of constant budget cuts and staff reductions can be and is a difficult task. It is no secret that NASA's current launching system consumes a very large portion of NASA funding and requires a large army of people to operate & maintain the system. The new Reusable Launch Vehicle (RLV) project and it's programs are faced with a monumental task of making the cost of access to space dramatically lower and more efficient than NASA's current system. With pressures from congressional budget cutters and also increased competition and loss of market share from international agencies RLV's first priority is to develop a 'low-cost, reliable transportation to earth orbit.' One of the RLV's major focus in achieving low-cost, reliable transportation to earth orbit is to rely on the maturing of advanced technologies. The technologies for the RLV are numerous and varied. Trying to assess their current status, within the RLV development program is paramount. There are several ways to assess these technologies. One way is through the use of Technology Readiness Levels (TRL's). This project focused on establishing current (summer 95) 'worst case' TRL's for six selected technologies that are under consideration for use within the RLV program. The six technologies evaluated were Concurrent Engineering, Embedded Sensor Technology, Rapid Prototyping, Friction Stir Welding, Thermal Spray Coatings, and VPPA Welding.

Emergency Management Span of Control: Optimizing Organizational Structures to Better Prepare Vermont for the Next Major or Catastrophic Disaster

DTIC Science & Technology

2008-12-01

full glare of media and public scrutiny, they are expected to perform flawlessly like a goalie in hockey or soccer, or a conversion kicker in...among all levels of government, not a plan that is pulled off the shelf only during worst- case disasters. The lifecycle of disasters entails a

Sports Competition--Integrated or Segregated? Which Is Better for Your Child?

ERIC Educational Resources Information Center

Grosse, Susan J.

2008-01-01

Selecting competitive sports opportunities for a child is a challenging process. Parents have to make the right choices so that their young athletes will have many years of healthy, happy, active experiences. If parents make the wrong choices, their son or daughter will have, at the very least, a few unhappy hours, and worst-case scenario, could…

Modelling the Growth of Swine Flu

ERIC Educational Resources Information Center

Thomson, Ian

2010-01-01

The spread of swine flu has been a cause of great concern globally. With no vaccine developed as yet, (at time of writing in July 2009) and given the fact that modern-day humans can travel speedily across the world, there are fears that this disease may spread out of control. The worst-case scenario would be one of unfettered exponential growth.…

Between the Under-Labourer and the Master-Builder: Observations on Bunge's Method

ERIC Educational Resources Information Center

Agassi, Joseph

2012-01-01

Mario Bunge has repeatedly discussed contributions to philosophy and to science that are worthless at best and dangerous at worst, especially cases of pseudo-science. He clearly gives his reason in his latest essay on this matter: "The fact that science can be faked to the point of deceiving science lovers suggests the need for a rigorous sifting…

Technology, design, simulation, and evaluation for SEP-hardened circuits

NASA Technical Reports Server (NTRS)

Adams, J. R.; Allred, D.; Barry, M.; Rudeck, P.; Woodruff, R.; Hoekstra, J.; Gardner, H.

1991-01-01

This paper describes the technology, design, simulation, and evaluation for improvement of the Single Event Phenomena (SEP) hardness of gate-array and SRAM cells. Through the use of design and processing techniques, it is possible to achieve an SEP error rate less than 1.0 x 10(exp -10) errors/bit-day for a 9O percent worst-case geosynchronous orbit environment.

33 CFR 154.1047 - Response plan development and evaluation criteria for facilities that handle, store, or transport...

Code of Federal Regulations, 2011 CFR

2011-07-01

... evaluation criteria for facilities that handle, store, or transport Group V petroleum oils. 154.1047 Section... Group V petroleum oils. (a) An owner or operator of a facility that handles, stores, or transports Group...) Procedures and strategies for responding to a worst case discharge of Group V petroleum oils to the maximum...

33 CFR 154.1047 - Response plan development and evaluation criteria for facilities that handle, store, or transport...

Code of Federal Regulations, 2013 CFR

2013-07-01

... evaluation criteria for facilities that handle, store, or transport Group V petroleum oils. 154.1047 Section... Group V petroleum oils. (a) An owner or operator of a facility that handles, stores, or transports Group...) Procedures and strategies for responding to a worst case discharge of Group V petroleum oils to the maximum...

33 CFR 154.1047 - Response plan development and evaluation criteria for facilities that handle, store, or transport...

Code of Federal Regulations, 2010 CFR

2010-07-01

... evaluation criteria for facilities that handle, store, or transport Group V petroleum oils. 154.1047 Section... Group V petroleum oils. (a) An owner or operator of a facility that handles, stores, or transports Group...) Procedures and strategies for responding to a worst case discharge of Group V petroleum oils to the maximum...

33 CFR 154.1047 - Response plan development and evaluation criteria for facilities that handle, store, or transport...

Code of Federal Regulations, 2014 CFR

2014-07-01

... evaluation criteria for facilities that handle, store, or transport Group V petroleum oils. 154.1047 Section... Group V petroleum oils. (a) An owner or operator of a facility that handles, stores, or transports Group...) Procedures and strategies for responding to a worst case discharge of Group V petroleum oils to the maximum...

33 CFR 154.1047 - Response plan development and evaluation criteria for facilities that handle, store, or transport...

Code of Federal Regulations, 2012 CFR

2012-07-01

... evaluation criteria for facilities that handle, store, or transport Group V petroleum oils. 154.1047 Section... Group V petroleum oils. (a) An owner or operator of a facility that handles, stores, or transports Group...) Procedures and strategies for responding to a worst case discharge of Group V petroleum oils to the maximum...

40 CFR Appendix A to Subpart Ddddd... - Methodology and Criteria for Demonstrating Eligibility for the Health-Based Compliance Alternatives

Code of Federal Regulations, 2012 CFR

2012-07-01

... rate, type of control devices, process parameters (e.g., maximum heat input), and non-process... control systems (if applicable) and explain why the conditions are worst-case. (c) Number of test runs... located at the outlet of the control device and prior to any releases to the atmosphere. (e) Collection of...

40 CFR Appendix A to Subpart Ddddd... - Methodology and Criteria for Demonstrating Eligibility for the Health-Based Compliance Alternatives

Code of Federal Regulations, 2011 CFR

2011-07-01

... rate, type of control devices, process parameters (e.g., maximum heat input), and non-process... control systems (if applicable) and explain why the conditions are worst-case. (c) Number of test runs... located at the outlet of the control device and prior to any releases to the atmosphere. (e) Collection of...

40 CFR Appendix A to Subpart Ddddd... - Methodology and Criteria for Demonstrating Eligibility for the Health-Based Compliance Alternatives

Code of Federal Regulations, 2010 CFR

2010-07-01

... rate, type of control devices, process parameters (e.g., maximum heat input), and non-process... control systems (if applicable) and explain why the conditions are worst-case. (c) Number of test runs... located at the outlet of the control device and prior to any releases to the atmosphere. (e) Collection of...

The conservation of diversity in forest trees

Treesearch

F. Thomas Ledig

1988-01-01

Deforestation, pollution, and climatic change threaten forest diversity all over the world. And because forests are the habitats for diverse organisms, the threat is extended to all the flora and fauna associated with forests, not only forest trees. In a worst case scenario, if the tropical forest in Latin America was reduced to the areas now set aside in parks and...

Management adaptation to fires in the wildland-urban risk areas in Spain

Treesearch

Gema Herrero-Corral

2013-01-01

Forest fires not only cause damage to ecosystems but also result in major socio-economic losses and in the worst cases loss of human life. Specifically, the incidence of fires in the overlapping areas between building structures and forest vegetation (wildland-urban interface, WUI) generates highly-complex emergencies due to the presence of people and goods....

Level II scour analysis for Bridge 38 (RANDTH00640038) on Town Highway 64, crossing the Second Branch of the White River, Randolph, Vermont

USGS Publications Warehouse

Olson, Scott A.

1996-01-01

Contraction scour for all modelled flows ranged from 1.7 to 2.6 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 7.2 to 24.2 ft. The worst-case abutment scour also occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Thermal Performance of LANDSAT-7 ETM+ Instruments During First Year in Flight

NASA Technical Reports Server (NTRS)

Choi, Michael K.

2000-01-01

Landsat-7 was successfully launched into orbit on April 15, 1999. After devoting three months to the t bakeout and cool-down of the radiative cooler, and on- t orbit checkout, the Enhanced Thematic Mapper Plus (ETM+) began the normal imaging phase of the mission in mid-July 1999. This paper presents the thermal performance of the ETM+ from mid-July 1999 to mid-May 2000. The flight temperatures are compared to the yellow temperature limits, and worst cold case and worst hot case flight temperature predictions in the 15-orbit mission design profile. The flight temperature predictions were generated by a thermal model, which was correlated to the observatory thermal balance test data. The yellow temperature limits were derived from the flight temperature predictions, plus some margins. The yellow limits work well in flight, so that only several minor changes to them were needed. Overall, the flight temperatures and flight temperature predictions have good agreement. Based on the ETM+ thermal vacuum qualification test, new limits on the imaging time are proposed to increase the average duty cycle, and to resolve the problems experienced by the Mission Operation Team.

Level II scour analysis for Bridge 36 (RANDTH00480036) on Town Highway 48, crossing Snows Brook, Randolph, Vermont

USGS Publications Warehouse

Olson, Scott A.

1996-01-01

Contraction scour for all modelled flows ranged from 0.0 to 0.8 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 6.1 to 11.6 ft. The worst-case abutment scour occurred at the incipient-overtopping discharge, which was 50 cfs lower than the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scouredstreambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particlesize distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Dynamic safety assessment of natural gas stations using Bayesian network.

PubMed

Zarei, Esmaeil; Azadeh, Ali; Khakzad, Nima; Aliabadi, Mostafa Mirzaei; Mohammadfam, Iraj

2017-01-05

Pipelines are one of the most popular and effective ways of transporting hazardous materials, especially natural gas. However, the rapid development of gas pipelines and stations in urban areas has introduced a serious threat to public safety and assets. Although different methods have been developed for risk analysis of gas transportation systems, a comprehensive methodology for risk analysis is still lacking, especially in natural gas stations. The present work is aimed at developing a dynamic and comprehensive quantitative risk analysis (DCQRA) approach for accident scenario and risk modeling of natural gas stations. In this approach, a FMEA is used for hazard analysis while a Bow-tie diagram and Bayesian network are employed to model the worst-case accident scenario and to assess the risks. The results have indicated that the failure of the regulator system was the worst-case accident scenario with the human error as the most contributing factor. Thus, in risk management plan of natural gas stations, priority should be given to the most probable root events and main contribution factors, which have identified in the present study, in order to reduce the occurrence probability of the accident scenarios and thus alleviate the risks. Copyright © 2016 Elsevier B.V. All rights reserved.

Level II scour analysis for Bridge 42 (BENNCYSCHL0042) on School Street, crossing Walloomsac River, Bennington, Vermont

USGS Publications Warehouse

Olson, Scott A.; Degnan, James R.

1997-01-01

Contraction scour computed for all modelled flows was 0.0 ft. Computed left abutment scour ranged from 9.4 to 10.2 ft. with the worst-case scour occurring at the 500-year discharge. Computed right abutment scour ranged from 2.7 to 5.7 ft. with the worst-case scour occurring at the incipient roadway-overtopping discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 46 (ENOSVT01080046) on State Route 108, crossing an Unnamed "The Branch" Tributary, Enosburg, Vermont

USGS Publications Warehouse

Boehmler, Erick M.; Medalie, Laura

1996-01-01

Contraction scour for all modelled flows ranged from 0.3 to 0.5 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 4.0 to 8.0 ft. The worst-case abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 30 (BRNATH00470030) on Town Highway 47, crossing Locust Creek, Barnard, Vermont

USGS Publications Warehouse

Boehmler, Erick M.; Song, Donald L.

1997-01-01

Contraction scour for all modelled flows ranged from 0.0 to 1.4 feet. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 2.3 to 8.9 feet. The worst-case abutment scour occurred at the 100-year discharge at the right abutment. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

A Minimax Network Flow Model for Characterizing the Impact of Slot Restrictions

NASA Technical Reports Server (NTRS)

Lee, Douglas W.; Patek, Stephen D.; Alexandrov, Natalia; Bass, Ellen J.; Kincaid, Rex K.

2010-01-01

This paper proposes a model for evaluating long-term measures to reduce congestion at airports in the National Airspace System (NAS). This model is constructed with the goal of assessing the global impacts of congestion management strategies, specifically slot restrictions. We develop the Minimax Node Throughput Problem (MINNTHRU), a multicommodity network flow model that provides insight into air traffic patterns when one minimizes the worst-case operation across all airports in a given network. MINNTHRU is thus formulated as a model where congestion arises from network topology. It reflects not market-driven airline objectives, but those of a regulatory authority seeking a distribution of air traffic beneficial to all airports, in response to congestion management measures. After discussing an algorithm for solving MINNTHRU for moderate-sized (30 nodes) and larger networks, we use this model to study the impacts of slot restrictions on the operation of an entire hub-spoke airport network. For both a small example network and a medium-sized network based on 30 airports in the NAS, we use MINNTHRU to demonstrate that increasing the severity of slot restrictions increases the traffic around unconstrained hub airports as well as the worst-case level of operation over all airports.

Level II scour analysis for Bridge 25 (DANVTH00610025) on Town Highway 61, crossing Water Andric Brook, Danville, Vermont

USGS Publications Warehouse

Flynn, Robert H.; Severance, Timothy

1997-01-01

Contraction scour for all modelled flows ranged from 0.7 to 1.3 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 9.1 to 12.5 ft. The worst-case abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 8 (WELLTH00020008) on Town Highway 2, crossing Wells Brook, Wells, Vermont

USGS Publications Warehouse

Striker, Lora K.; Ivanoff, Michael A.

1997-01-01

Contraction scour for all modelled flows ranged from 0.0 to 0.8 ft. The worst-case contraction scour occurred at the incipient roadway-overtopping discharge, which was less than the 100-year discharge. Abutment scour ranged from 5.6 to 10.0 ft at the left abutment and from 3.1 to 4.2 ft at the right abutment. The worst-case abutment scour occurred at the incipient roadway-overtopping discharge at the left abutment. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 39 (TOPSTH00510039) on Town Highway 51, crossing Tabor Branch Waits River, Topsham, Vermont

USGS Publications Warehouse

Striker, Lora K.; Severance, Tim

1997-01-01

Contraction scour for all modelled flows ranged from 0.0 to 0.4 ft. The worst-case contraction scour occurred at the maximum free surface flow discharge, which was less than the 100-year discharge. Abutment scour ranged from 4.8 to 8.0 ft. The worst-case abutment scour occurred at 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A crosssection of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 145 (HANCVT01000145) on Vermont Highway 100, crossing the Hancock Branch of the White River, Hancock, Vermont

USGS Publications Warehouse

Ivanoff, Michael A.; Hammond, Robert E.

1996-01-01

Contraction scour for all modelled flows ranged from 3.4 to 4.3 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 8.2 to 11.1 ft. The worst-case abutment scour occurred at the 100-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

How safe is safe enough. The relation of environmental characteristics and economic competitiveness in fusion-reactor design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holdren, J.P.

The need for fusion energy depends strongly on fusion's potential to achieve ambitious safety goals more completely or more economically than fission can. The history and present complexion of public opinion about environment and safety gives little basis for expecting either that these concerns will prove to be a passing fad or that the public will make demands for zero risk that no energy source can meet. Hazard indices based on ''worst case'' accidents and exposures should be used as design tools to promote combinations of fusion-reactor materials and configurations that bring the worst cases down to levels small comparedmore » to the hazards people tolerate from electricity at the point of end use. It may well be possible, by building such safety into fusion from the ground up, to accomplish this goal at costs competitive with other inexhaustible electricity sources. Indeed, the still rising and ultimately indeterminate costs of meeting safety and environmental requirements in nonbreeder fission reactors and coal-burning power plants mean that fusion reactors meeting ambitious safety goals may be able to compete economically with these ''interim'' electricity sources as well.« less

Level II scour analysis for Bridge 5 (MORRTH00060005) on Town Highway 6, crossing Bedell Brook, Morristown, Vermont

USGS Publications Warehouse

Boehmler, Erick M.; Degnan, James R.

1997-01-01

Contraction scour for all modelled flows ranged from 1.1 to 2.0 feet. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 3.9 to 8.6 feet. The worst-case abutment scour occurred at the 500-year event. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model.

PubMed

Frederiksen, Marie; Vorkamp, Katrin; Jensen, Niels Martin; Sørensen, Jens Ahm; Knudsen, Lisbeth E; Sørensen, Lars S; Webster, Thomas F; Nielsen, Jesper B

2016-11-01

The dermal uptake and percutaneous penetration of ten organic flame retardants was measured using an ex vivo human skin model. The studied compounds were DBDPE, BTBPE, TBP-DBPE, EH-TBB, BEH-TEBP, α, β and γ-HBCDD as well as syn- and anti-DDC-CO. Little or none of the applied flame retardants was recovered in either type of the receptor fluids used (physiological and worst-case). However, significant fractions were recovered in the skin depot, particularly in the upper skin layers. The primary effect of the worst-case receptor fluid was deeper penetration into the skin. The recovered mass was used to calculate lower- and upper-bound permeability coefficients kp. Despite large structural variation between the studied compounds, a clear, significant decreasing trend of kp was observed with increasing log Kow. The results indicate that the dermis may provide a significant barrier for these highly lipophilic compounds. However, based on our results, dermal uptake should be considered in exposure assessments, though it may proceed in a time-lagged manner compared to less hydrophobic compounds. Copyright © 2016 Elsevier Ltd. All rights reserved.

Level II scour analysis for Bridge 25 (CLARTH00100025) on Town Highway 10, crossing the Clarendon River, Clarendon, Vermont

USGS Publications Warehouse

Ayotte, Joseph D.

1996-01-01

Contraction scour for all modelled flows ranged from 0.0 to 0.8 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 5.7 to 10.6 ft. The worst-case abutment scour also occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for brigde 5 (STOCTH00360005) on Town Highway 36, crossing Stony Brook, Stockridge, Vermont

USGS Publications Warehouse

Striker, Lora K.; Weber, Matthew A.

1998-01-01

Contraction scour for all modelled flows ranged from 2.0 to 3.2 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 9.7 to 22.2 ft. The worst-case abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and Davis, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

New Algorithms and Lower Bounds for Sequential-Access Data Compression

NASA Astrophysics Data System (ADS)

Gagie, Travis

2009-02-01

This thesis concerns sequential-access data compression, i.e., by algorithms that read the input one or more times from beginning to end. In one chapter we consider adaptive prefix coding, for which we must read the input character by character, outputting each character's self-delimiting codeword before reading the next one. We show how to encode and decode each character in constant worst-case time while producing an encoding whose length is worst-case optimal. In another chapter we consider one-pass compression with memory bounded in terms of the alphabet size and context length, and prove a nearly tight tradeoff between the amount of memory we can use and the quality of the compression we can achieve. In a third chapter we consider compression in the read/write streams model, which allows us passes and memory both polylogarithmic in the size of the input. We first show how to achieve universal compression using only one pass over one stream. We then show that one stream is not sufficient for achieving good grammar-based compression. Finally, we show that two streams are necessary and sufficient for achieving entropy-only bounds.

On the Convergence Analysis of the Optimized Gradient Method.

PubMed

Kim, Donghwan; Fessler, Jeffrey A

2017-01-01

This paper considers the problem of unconstrained minimization of smooth convex functions having Lipschitz continuous gradients with known Lipschitz constant. We recently proposed the optimized gradient method for this problem and showed that it has a worst-case convergence bound for the cost function decrease that is twice as small as that of Nesterov's fast gradient method, yet has a similarly efficient practical implementation. Drori showed recently that the optimized gradient method has optimal complexity for the cost function decrease over the general class of first-order methods. This optimality makes it important to study fully the convergence properties of the optimized gradient method. The previous worst-case convergence bound for the optimized gradient method was derived for only the last iterate of a secondary sequence. This paper provides an analytic convergence bound for the primary sequence generated by the optimized gradient method. We then discuss additional convergence properties of the optimized gradient method, including the interesting fact that the optimized gradient method has two types of worstcase functions: a piecewise affine-quadratic function and a quadratic function. These results help complete the theory of an optimal first-order method for smooth convex minimization.

Level II scour analysis for Bridge 17 (POMFTH00010017) on Town Highway 1 (FAS 166) crossing Mill Brook, Pomfret, Vermont

USGS Publications Warehouse

Boehmler, Erick M.; Hammond, Robert E.

1997-01-01

Contraction scour for all modelled flows ranged from 0.0 to 0.9 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 3.6 to 7.1 ft. The worst-case abutment scour also occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Hurricane Rita and the destruction of Holly Beach, Louisiana: Why the chenier plain is vulnerable to storms

USGS Publications Warehouse

Sallenger, A.H.; Wright, C.W.; Doran, K.; Guy, K.; Morgan, K.

2009-01-01

Hurricane Rita devastated gulf-front communities along the western Louisiana coast in 2005. LIDAR (light detection and ranging) topographic surveys and aerial photography collected before and after the storm showed the loss of every structure within the community of Holly Beach. Average shoreline change along western Louisiana's 140-km-long impacted shore was -23.3 ?? 30.1 m of erosion, although shoreline change in Holly Beach was substantially less, and erosion was not pervasive where the structures were lost. Before the storm, peak elevations of the dunes, or berms in the absence of dunes, along the impacted shore averaged 1.6 m. The storm surge, which reached 3.5 m just east of Holly Beach, completely inundated the beach systems along the impacted western Louisiana shore. The high surge potential and low land elevations make this coast extremely vulnerable to hurricanes. In fact, most of the western Louisiana shore impacted by Rita will be completely inundated by the storm surge of a worst-case Saffi r-Simpson category 1 hurricane. All of this shore will be inundated by worst-case category 2-5 storms. ?? 2009 The Geological Society of America.

Quantum Discord Determines the Interferometric Power of Quantum States

NASA Astrophysics Data System (ADS)

Girolami, Davide; Souza, Alexandre M.; Giovannetti, Vittorio; Tufarelli, Tommaso; Filgueiras, Jefferson G.; Sarthour, Roberto S.; Soares-Pinto, Diogo O.; Oliveira, Ivan S.; Adesso, Gerardo

2014-05-01

Quantum metrology exploits quantum mechanical laws to improve the precision in estimating technologically relevant parameters such as phase, frequency, or magnetic fields. Probe states are usually tailored to the particular dynamics whose parameters are being estimated. Here we consider a novel framework where quantum estimation is performed in an interferometric configuration, using bipartite probe states prepared when only the spectrum of the generating Hamiltonian is known. We introduce a figure of merit for the scheme, given by the worst-case precision over all suitable Hamiltonians, and prove that it amounts exactly to a computable measure of discord-type quantum correlations for the input probe. We complement our theoretical results with a metrology experiment, realized in a highly controllable room-temperature nuclear magnetic resonance setup, which provides a proof-of-concept demonstration for the usefulness of discord in sensing applications. Discordant probes are shown to guarantee a nonzero phase sensitivity for all the chosen generating Hamiltonians, while classically correlated probes are unable to accomplish the estimation in a worst-case setting. This work establishes a rigorous and direct operational interpretation for general quantum correlations, shedding light on their potential for quantum technology.

On the Convergence Analysis of the Optimized Gradient Method

PubMed Central

Kim, Donghwan; Fessler, Jeffrey A.

2016-01-01

This paper considers the problem of unconstrained minimization of smooth convex functions having Lipschitz continuous gradients with known Lipschitz constant. We recently proposed the optimized gradient method for this problem and showed that it has a worst-case convergence bound for the cost function decrease that is twice as small as that of Nesterov’s fast gradient method, yet has a similarly efficient practical implementation. Drori showed recently that the optimized gradient method has optimal complexity for the cost function decrease over the general class of first-order methods. This optimality makes it important to study fully the convergence properties of the optimized gradient method. The previous worst-case convergence bound for the optimized gradient method was derived for only the last iterate of a secondary sequence. This paper provides an analytic convergence bound for the primary sequence generated by the optimized gradient method. We then discuss additional convergence properties of the optimized gradient method, including the interesting fact that the optimized gradient method has two types of worstcase functions: a piecewise affine-quadratic function and a quadratic function. These results help complete the theory of an optimal first-order method for smooth convex minimization. PMID:28461707

Level II scour analysis for Bridge 6 (VICTTH000110006) on Town Highway 1, crossing the Moose River, Victory, Vermont

USGS Publications Warehouse

Olson, Scott A.

1997-01-01

Contraction scour for all modelled flows ranged from 0.2 to 0.4 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 7.3 to 8.2 ft. The worst-case abutment scour also occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 8, (MANCTH00060008) on Town Highway 6, crossing Bourn Brook, Manchester, Vermont

USGS Publications Warehouse

Burns, Ronda L.; Hammond, Robert E.

1997-01-01

Contraction scour for all modelled flows was zero ft. The left abutment scour ranged from 3.6 to 9.2 ft. The worst-case left abutment scour occurred at the 500-year discharge. The right abutment scour ranged from 9.8 to 12.6 ft. The worst case right abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 36 (ANDOVT00110036) on VT 11, crossing Middle Branch Williams River, Andover, Vermont

USGS Publications Warehouse

Striker, Lora K.; Burns, Rhonda L.

1997-01-01

Contraction scour for all modelled flows ranged from 0.0 to 2.8 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 9.5 to 13.7 ft. The worst-case abutment scour also occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 6 (BRISVT01160006) on State Highway 116, crossing Little Notch Brook, Bristol, Vermont

USGS Publications Warehouse

Boehmler, Erick M.; Burns, Ronda L.

1997-01-01

Contraction scour for all modelled flows ranged from 3.2 to 4.3 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 6.0 to 10.0 ft. The worst-case abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 92 (WSTOVT01000092) on State Highway 100, crossing the West River, Weston, Vermont

USGS Publications Warehouse

Flynn, Robert H.; Burns, Ronda L.

1997-01-01

Contraction scour for all modelled flows ranged from 0.4 to 2.1 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 8.4 to 30.7 ft. The worst-case abutment scour occurred at the 500-year discharge along the left abutment. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 50 (STARTH00250050) on Town Highway 25, crossing Lewis Creek, Starksboro, Vermont

USGS Publications Warehouse

Burns, Ronda L.; Boehmler, Erick M.

1997-01-01

Contraction scour for all modelled flows ranged from 5.2 to 9.1 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 13.1 to 18.2 ft. The worst-case abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 4 (RYEGTH00050004) on Town Highway 5, crossing the Wells River, Ryegate, Vermont

USGS Publications Warehouse

Ivanoff, Michael A.; Hammond, Robert E.

1997-01-01

Contraction scour for all modelled flows ranged from 1.8 to 2.6 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 10.2 to 22.6 ft. The worst-case abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 46 (BRNETH00610046) on Town Highway 61, crossing East Peacham Brook, Barnet, Vermont

USGS Publications Warehouse

Ivanoff, Michael A.

1997-01-01

Contraction scour for all modelled flows ranged from 0 to 1.2 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 10.4 to 13.9 ft. The worst-case abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 45 (NFIETH00250045) on Town Highway 25, crossing Union Brook, Northfield, Vermont

USGS Publications Warehouse

Burns, Ronda L.; Ivanoff, Michael A.

1997-01-01

Contraction scour for all modelled flows ranged from 0.4 to 0.9 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 4.5 to 9.1 ft. The worst-case abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 21 (WALDTH00450021) on Town Highway 45, crossing Joes Brook, Walden, Vermont

USGS Publications Warehouse

Ivanoff, Michael A.; Medalie, Laura

1997-01-01

Contraction scour for all modelled flows ranged from 0.0 to 1.5 ft. The worst-case contraction scour occurred at the incipient roadway-overtopping discharge, which was less than the 100-year discharge. Abutment scour ranged from 12.4 to 24.4 ft. The worst-case abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scouredstreambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particlesize distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 81 (NFIETH00PL0081) on Pleasant Street, crossing Union Brook, Northfield, Vermont

USGS Publications Warehouse

Burns, Ronda L.; Medalie, Laura

1997-01-01

Contraction scour for all modelled flows ranged from 0.0 to 0.5 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 4.2 to 13.3 ft. The worst-case abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 9 (JAYVT02420009) on Vermont Highway 242, crossing the Jay Branch of the Missisquoi River, Jay, Vermont

USGS Publications Warehouse

Flynn, Robert H.; Ivanoff, Michael A.

1996-01-01

Contraction scour for all modelled flows ranged from 0.0 to 0.6 ft. The worst-case contraction scour occurred at the 100-year discharge. Abutment scour ranged from 0.8 to 5.6 ft. The worst-case abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Tsunami hazard assessment for the island of Rhodes, Greece

NASA Astrophysics Data System (ADS)

Pagnoni, Gianluca; Armigliato, Alberto; Zaniboni, Filippo; Tinti, Stefano

2013-04-01

The island of Rhodes is part of the Dodecanese archipelago, and is one of the many islands that are found in the Aegean Sea. The tectonics of the Rhodes area is rather complex, involving both strike-slip and dip-slip (mainly thrust) processes. Tsunami catalogues (e.g. Papadopulos et al, 2007) show the relative high frequency of occurrence of tsunamis in this area, some also destructive, in particular between the coasts of Rhodes and Turkey. In this part of the island is located the town of Rhodes, the capital and also the largest and most populated city. Rhodes is historically famous for the Colossus of Rhodes, collapsed following an earthquake, and nowadays is a popular tourist destination. This work is focused on the hazard assessment evaluation with research performed in the frame of the European project NearToWarn. The hazard is assessed by using the worst-credible case scenario, a method introduced and used to study local tsunami hazard in coastal towns like Catania, Italy, and Alexandria, Egypt (Tinti et al., 2012). The tsunami sources chosen for building scenarios are three: two located in the sea area in front of the Turkish coasts where the events are more frequent represent local sources and were selected in the frame of the European project NearToWarn, while one provides the case of a distant source. The first source is taken from the paper Ebeling et al. (2012) and modified by UNIBO and models the earthquake and small tsunami occurred on 25th April 1957.The second source is a landslide and is derived from the TRANSFER Project "Database of Tsunamigenic Non-Seismic Sources" and coincides with the so-called "Northern Rhodes Slide", possibly responsible for the 24th March 2002 tsunami. The last source is the fault that is located close to the island of Crete believed to be responsible for the tsunami event of 1303 that was reported to have caused damage in the city of Rhodes. The simulations are carried out using the finite difference code UBO-TSUFD that solves the Navier Stokes equations in shallow water approximation. To cover the entire basin two nested grids (a coarse one with 30 arc sec resolution and a finer one with 200 m resolution) are used, constructed on bathymetry data provided by the TRANSFER database. The results, as fields of highest wave elevation, maximum flood, maximum speed, arrival times and synthetic tide-gauges, are provided and discussed both individually (i.e. separately for each source) as well as in the form of a single, aggregate result, as required by the worst-case scenario technique. References Ebeling, C.W., Okal., E.A., Kalligeris, N., Synolakis, C.E.: Modern seismological reassessment and tsunami simulation of historical Hellenic Arc earthquakes. Tectonophysics, 530-531, 225-239, 2012. Papadopoulos, G. A., Daskalaki, E., Fokaefs, A., and Giraleas, N.: Tsunami hazards in the Eastern Mediterranean: strong earthquakes and tsunamis in the East Hellenic Arc and Trench system, Nat. Hazards Earth Syst. Sci., 7, 57-64, doi:10.5194/nhess-7-57-2007, 2007. Tinti S., Pagnoni G., Armigliato A., and Tonini R.: Tsunami inundation scenarios and tsunami vulnerability assessment forthe town of Alexandria, Egypt, Geophysical Research Abstracts Vol. 14, EGU2012-10325, 2012, EGU General Assembly 2012.

EPHECT II: Exposure assessment to household consumer products.

PubMed

Dimitroulopoulou, C; Trantallidi, M; Carrer, P; Efthimiou, G C; Bartzis, J G

2015-12-01

Within the framework of the EPHECT project (Emissions, exposure patterns and health effects of consumer products in the EU), irritative and respiratory health effects were assessed in relation to acute and long-term exposure to key and emerging indoor air pollutants emitted during household use of selected consumer products. In this context, inhalation exposure assessment was carried out for six selected 'target' compounds (acrolein, formaldehyde, benzene, naphthalene, d-limonene and α-pinene). This paper presents the methodology and the outcomes from the micro-environmental modelling of the 'target' pollutants following single or multiple use of selected consumer products and the subsequent exposure assessment. The results indicate that emissions from consumer products of benzene and α-pinene were not considered to contribute significantly to the EU indoor background levels, in contrast to some cases of formaldehyde and d-limonene emissions in Eastern Europe (mainly from cleaning products). The group of housekeepers in East Europe appears to experience the highest exposures to acrolein, formaldehyde and benzene, followed by the group of the retired people in North, who experiences the highest exposures to naphthalene and α-pinene. High exposure may be attributed to the scenarios developed within this project, which follow a 'most-representative worst-case scenario' strategy for exposure and health risk assessment. Despite the above limitations, this is the first comprehensive study that provides exposure estimates for 8 population groups across Europe exposed to 6 priority pollutants, as a result of the use of 15 consumer product classes in households, while accounting for regional differences in uses, use scenarios and ventilation conditions of each region. Crown Copyright © 2015. Published by Elsevier B.V. All rights reserved.

Hydrological and water quality impact assessment of a Mediterranean limno-reservoir under climate change and land use management scenarios

NASA Astrophysics Data System (ADS)

Molina-Navarro, Eugenio; Trolle, Dennis; Martínez-Pérez, Silvia; Sastre-Merlín, Antonio; Jeppesen, Erik

2014-02-01

Water scarcity and water pollution constitute a big challenge for water managers in the Mediterranean region today and will exacerbate in a projected future warmer world, making a holistic approach for water resources management at the catchment scale essential. We expanded the Soil and Water Assessment Tool (SWAT) model developed for a small Mediterranean catchment to quantify the potential effects of various climate and land use change scenarios on catchment hydrology as well as the trophic state of a new kind of waterbody, a limno-reservoir (Pareja Limno-reservoir), created for environmental and recreational purposes. We also checked for the possible synergistic effects of changes in climate and land use on water flow and nutrient exports from the catchment. Simulations showed a noticeable impact of climate change in the river flow regime and consequently the water level of the limno-reservoir, especially during summer, complicating the fulfillment of its purposes. Most of the scenarios also predicted a deterioration of trophic conditions in the limno-reservoir. Fertilization and soil erosion were the main factors affecting nitrate and total phosphorus concentrations. Combined climate and land use change scenarios showed noticeable synergistic effects on nutrients exports, relative to running the scenarios individually. While the impact of fertilization on nitrate export is projected to be reduced with warming in most cases, an additional 13% increase in the total phosphorus export is expected in the worst-case combined scenario compared to the sum of individual scenarios. Our model framework may help water managers to assess and manage how these multiple environmental stressors interact and ultimately affect aquatic ecosystems.

Lung tumor tracking in fluoroscopic video based on optical flow

PubMed Central

Xu, Qianyi; Hamilton, Russell J.; Schowengerdt, Robert A.; Alexander, Brian; Jiang, Steve B.

2008-01-01

Respiratory gating and tumor tracking for dynamic multileaf collimator delivery require accurate and real-time localization of the lung tumor position during treatment. Deriving tumor position from external surrogates such as abdominal surface motion may have large uncertainties due to the intra- and interfraction variations of the correlation between the external surrogates and internal tumor motion. Implanted fiducial markers can be used to track tumors fluoroscopically in real time with sufficient accuracy. However, it may not be a practical procedure when implanting fiducials bronchoscopically. In this work, a method is presented to track the lung tumor mass or relevant anatomic features projected in fluoroscopic images without implanted fiducial markers based on an optical flow algorithm. The algorithm generates the centroid position of the tracked target and ignores shape changes of the tumor mass shadow. The tracking starts with a segmented tumor projection in an initial image frame. Then, the optical flow between this and all incoming frames acquired during treatment delivery is computed as initial estimations of tumor centroid displacements. The tumor contour in the initial frame is transferred to the incoming frames based on the average of the motion vectors, and its positions in the incoming frames are determined by fine-tuning the contour positions using a template matching algorithm with a small search range. The tracking results were validated by comparing with clinician determined contours on each frame. The position difference in 95% of the frames was found to be less than 1.4 pixels (∼0.7 mm) in the best case and 2.8 pixels (∼1.4 mm) in the worst case for the five patients studied. PMID:19175094

Lung tumor tracking in fluoroscopic video based on optical flow.

PubMed

Xu, Qianyi; Hamilton, Russell J; Schowengerdt, Robert A; Alexander, Brian; Jiang, Steve B

2008-12-01

Respiratory gating and tumor tracking for dynamic multileaf collimator delivery require accurate and real-time localization of the lung tumor position during treatment. Deriving tumor position from external surrogates such as abdominal surface motion may have large uncertainties due to the intra- and interfraction variations of the correlation between the external surrogates and internal tumor motion. Implanted fiducial markers can be used to track tumors fluoroscopically in real time with sufficient accuracy. However, it may not be a practical procedure when implanting fiducials bronchoscopically. In this work, a method is presented to track the lung tumor mass or relevant anatomic features projected in fluoroscopic images without implanted fiducial markers based on an optical flow algorithm. The algorithm generates the centroid position of the tracked target and ignores shape changes of the tumor mass shadow. The tracking starts with a segmented tumor projection in an initial image frame. Then, the optical flow between this and all incoming frames acquired during treatment delivery is computed as initial estimations of tumor centroid displacements. The tumor contour in the initial frame is transferred to the incoming frames based on the average of the motion vectors, and its positions in the incoming frames are determined by fine-tuning the contour positions using a template matching algorithm with a small search range. The tracking results were validated by comparing with clinician determined contours on each frame. The position difference in 95% of the frames was found to be less than 1.4 pixels (approximately 0.7 mm) in the best case and 2.8 pixels (approximately 1.4 mm) in the worst case for the five patients studied.

The Effect of Sonic Booms on Earthquake Warning Systems

NASA Technical Reports Server (NTRS)

Wurman, Gilead; Haering, Edward A, Jr.; Price, Michael J.

2011-01-01

Several aerospace companies are designing quiet supersonic business jets for service over the United States. These aircraft have the potential to increase the occurrence of mild sonic booms across the country. This leads to interest among earthquake warning (EQW) developers and the general seismological community in characterizing the effect of sonic booms on seismic sensors in the field, their potential impact on EQW systems, and means of discriminating their signatures from those of earthquakes. The SonicBREWS project (Sonic Boom Resistant Earthquake Warning Systems) is a collaborative effort between Seismic Warning Systems, Inc. (SWS) and NASA Dryden Flight Research Center. This project aims to evaluate the effects of sonic booms on EQW sensors. The study consists of exposing high-sample-rate (1000 sps) triaxial accelerometers to sonic booms with overpressures ranging from 10 to 600 Pa in the free field and the built environment. The accelerometers record the coupling of the sonic boom to the ground and surrounding structures, while microphones record the acoustic wave above ground near the sensor. Sonic booms are broadband signals with more high-frequency content than earthquakes. Even a 1000 sps accelerometer will produce a significantly aliased record. Thus the observed peak ground velocity is strongly dependent on the sampling rate, and increases as the sampling rate is reduced. At 1000 sps we observe ground velocities that exceed those of P-waves from M_L 3 earthquakes at local distances, suggesting that sonic booms are not negligible for EQW applications. We present the results of several experiments conducted under SonicBREWS showing the effects of typical-case low amplitude sonic booms and worst-case high amplitude booms. We show the effects of various sensor placements and sensor array geometries. Finally, we suggest possible avenues for discriminating sonic booms from earthquakes for the purposes of EQW.

A case-control, mono-center, open-label, pilot study to evaluate the feasibility of therapeutic touch in preventing radiation dermatitis in women with breast cancer receiving adjuvant radiation therapy.

PubMed

Younus, Jawaid; Lock, Michael; Vujovic, Olga; Yu, Edward; Malec, Jitka; D'Souza, David; Stitt, Larry

2015-08-01

Therapeutic touch (TT) is a non-invasive commonly used complementary therapy. TT is based on the use of hand movements and detection of energy field congestion to correct imbalances. Improvement in subjective symptoms in a variety of clinical trials has been seen with TT. The effect of TT during radiotherapy for breast cancer is unknown. Women undergoing adjuvant radiation for Stage I/II breast cancer post conservative surgery were recruited for this cohort study. TT treatments were administered three times per week following radiation therapy. Feasibility was defined as an a priori threshold of 15 of 17 patients completing all TT treatments. The preventive effectiveness of TT was evaluated by documenting the 'time to develop' and the 'worst grade of radiation' dermatitis. Toxicity was assessed using NCIC CTC V3 dermatitis scale. Cosmetic rating was performed using the EORTC Breast Cosmetic Rating. The quality of life, mood and energy, and fatigue were assessed by EORTC QLQ C30, POMS, and BFI, respectively. The parameters were assessed at baseline, and serially during treatment. A total of 49 patients entered the study (17 in the TT Cohort and 32 in the Control Cohort). Median age in TT arm was 63 years and in control arm was 59 years. TT was considered feasible as all 17 patients screened completed TT treatment. There were no side effects observed with the TT treatments. In the TT Cohort, the worst grade of radiation dermatitis was grade II in nine patients (53%). Median time to develop the worst grade was 22 days. In the Control Cohort, the worst grade of radiation dermatitis was grade III in 1 patient. However, the most common toxicity grade was II in 15 patients (47%). Three patients did not develop any dermatitis. Median time to develop the worst grade in the control group was 31 days. There was no difference between cohorts for the overall EORTC cosmetic score and there was no significant difference in before and after study levels in quality of life, mood and fatigue. This study is the first evaluation of TT in patients with breast cancer using objective measures. Although TT is feasible for the management of radiation induced dermatitis, we were not able to detect a significant benefit of TT on NCIC toxicity grade or time to develop the worst grade for radiation dermatitis. In addition, TT did not improve quality of life, mood, fatigue and overall cosmetic outcome. Copyright © 2014 Elsevier Ltd. All rights reserved.

Climate Change Impacts on the Tree of Life: Changes in Phylogenetic Diversity Illustrated for Acropora Corals

PubMed Central

Faith, Daniel P.; Richards, Zoe T.

2012-01-01

The possible loss of whole branches from the tree of life is a dramatic, but under-studied, biological implication of climate change. The tree of life represents an evolutionary heritage providing both present and future benefits to humanity, often in unanticipated ways. Losses in this evolutionary (evo) life-support system represent losses in “evosystem” services, and are quantified using the phylogenetic diversity (PD) measure. High species-level biodiversity losses may or may not correspond to high PD losses. If climate change impacts are clumped on the phylogeny, then loss of deeper phylogenetic branches can mean disproportionately large PD loss for a given degree of species loss. Over time, successive species extinctions within a clade each may imply only a moderate loss of PD, until the last species within that clade goes extinct, and PD drops precipitously. Emerging methods of “phylogenetic risk analysis” address such phylogenetic tipping points by adjusting conservation priorities to better reflect risk of such worst-case losses. We have further developed and explored this approach for one of the most threatened taxonomic groups, corals. Based on a phylogenetic tree for the corals genus Acropora, we identify cases where worst-case PD losses may be avoided by designing risk-averse conservation priorities. We also propose spatial heterogeneity measures changes to assess possible changes in the geographic distribution of corals PD. PMID:24832524

A STRICTLY CONTRACTIVE PEACEMAN-RACHFORD SPLITTING METHOD FOR CONVEX PROGRAMMING.

PubMed

Bingsheng, He; Liu, Han; Wang, Zhaoran; Yuan, Xiaoming

2014-07-01

In this paper, we focus on the application of the Peaceman-Rachford splitting method (PRSM) to a convex minimization model with linear constraints and a separable objective function. Compared to the Douglas-Rachford splitting method (DRSM), another splitting method from which the alternating direction method of multipliers originates, PRSM requires more restrictive assumptions to ensure its convergence, while it is always faster whenever it is convergent. We first illustrate that the reason for this difference is that the iterative sequence generated by DRSM is strictly contractive, while that generated by PRSM is only contractive with respect to the solution set of the model. With only the convexity assumption on the objective function of the model under consideration, the convergence of PRSM is not guaranteed. But for this case, we show that the first t iterations of PRSM still enable us to find an approximate solution with an accuracy of O (1/ t ). A worst-case O (1/ t ) convergence rate of PRSM in the ergodic sense is thus established under mild assumptions. After that, we suggest attaching an underdetermined relaxation factor with PRSM to guarantee the strict contraction of its iterative sequence and thus propose a strictly contractive PRSM. A worst-case O (1/ t ) convergence rate of this strictly contractive PRSM in a nonergodic sense is established. We show the numerical efficiency of the strictly contractive PRSM by some applications in statistical learning and image processing.

Specific exercises reduce brace prescription in adolescent idiopathic scoliosis: a prospective controlled cohort study with worst-case analysis.

PubMed

Negrini, Stefano; Zaina, Fabio; Romano, Michele; Negrini, Alessandra; Parzini, Silvana

2008-06-01

To compare the effect of Scientific Exercises Approach to Scoliosis (SEAS) exercises with "usual care" rehabilitation programmes in terms of the avoidance of brace prescription and prevention of curve progression in adolescent idiopathic scoliosis. Prospective controlled cohort observational study. Seventy-four consecutive outpatients with adolescent idiopathic scoliosis, mean 15 degrees (standard deviation 6) Cobb angle, 12.4 (standard deviation 2.2) years old, at risk of bracing who had not been treated previously. Thirty-five patients were included in the SEAS exercises group and 39 in the usual physiotherapy group. The primary outcome included the number of braced patients, Cobb angle and the angle of trunk rotation. There were 6.1% braced patients in the SEAS exercises group vs 25.0% in the usual physiotherapy group. Failures of treatment in the worst-case analysis were 11.5% and 30.8%, respectively. In both cases the differences were statistically significant. Cobb angle improved in the SEAS exercises group, but worsened in the usual physiotherapy group. In the SEAS exercises group, 23.5% of patients improved and 11.8% worsened, while in the usual physiotherapy group 11.1% improved and 13.9% worsened. These data confirm the effectiveness of exercises in patients with scoliosis who are at high risk of progression. Compared with non-adapted exercises, a specific and personalized treatment (SEAS) appears to be more effective.

Level II scour analysis for Bridge 23 (CRAFTH00390023) on Town Highway 39, crossing the Black River, Craftsbury, Vermont

USGS Publications Warehouse

Boehmler, Erick M.

1997-01-01

Contraction scour for all modelled flows ranged from 20.1 to 25.2 and the worst-case contraction scour occurred at the 500-year discharge. Although this bridge has two piers, the flow through the spans between each abutment and pier is assumed to be negligible. Hence, abutment scour was computed assuming the forces contributing to scour actually occur on the main-span sides of each pier in this case. Abutment scour ranged from 8.8 to 10.6 and the worst-case abutment scour occurred at the 500-year discharge. Scour depths and depths to armoring are summarized on p. 14 in the section titled “Scour Results”. Scour elevations, based on the calculated depths are presented in tables 1 and 2. A graph of the scour elevations is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Unmet Expectations and Symptoms of Depression among the Three Gorges Project Resettlers

PubMed Central

Xi, Juan; Hwang, Sean-Shong

2010-01-01

To successfully resettle 1.27 million Chinese for the construction of the Three Gorges Project (TGP), the Chinese government employed a new re-resettlement policy which emphasizes infrastructural development of the resettlement sites to assure resettlers a sustainable livelihood following resettlement. Unfortunately, many benefits the policy promised have not materialized. As a result, many resettlers have suffered an increase in depressive symptoms associated with unmet expectations. Using panel data collected before and after relocation from a sample of Three Gorges resettlers, we found that a high proportion of resettlers reported unmet expectations which were significantly associated with an increase in depressive symptoms. Our findings indicate that undeliverable promises can backfire and further aggravate the harm inflicted on the displaced caused by the project-induced displacement. From the perspective of resettlers, a sound coping strategy to minimize the harm caused by the displacement on their mental wellbeing is to expect for the worst. PMID:21278844

International Neural Network Society Annual Meeting (1994) Held in San Diego, California on 5-9 June 1994. Volume 2

DTIC Science & Technology

1994-06-09

following dominating factor. A(L) - I r- (17) where sat(x)X i ox1. Then the above description can be expressed as the following equation: where uw is the...Electrical & Computer Engineering University of Wisconsin- Madison 1415 Johnson Drive Madison , WI 53706-1691 USA Abstract - Iterative least-mean square...u, = u:,. for all k. The worst-case relative mismatch for the case considered is then given by - ut,, . . = 28 (22) UW - 1+8., where 6 = Ao / o. For

Default values for assessment of potential dermal exposure of the hands to industrial chemicals in the scope of regulatory risk assessments.

PubMed

Marquart, Hans; Warren, Nicholas D; Laitinen, Juha; van Hemmen, Joop J

2006-07-01

Dermal exposure needs to be addressed in regulatory risk assessment of chemicals. The models used so far are based on very limited data. The EU project RISKOFDERM has gathered a large number of new measurements on dermal exposure to industrial chemicals in various work situations, together with information on possible determinants of exposure. These data and information, together with some non-RISKOFDERM data were used to derive default values for potential dermal exposure of the hands for so-called 'TGD exposure scenarios'. TGD exposure scenarios have similar values for some very important determinant(s) of dermal exposure, such as amount of substance used. They form narrower bands within the so-called 'RISKOFDERM scenarios', which cluster exposure situations according to the same purpose of use of the products. The RISKOFDERM scenarios in turn are narrower bands within the so-called Dermal Exposure Operation units (DEO units) that were defined in the RISKOFDERM project to cluster situations with similar exposure processes and exposure routes. Default values for both reasonable worst case situations and typical situations were derived, both for single datasets and, where possible, for combined datasets that fit the same TGD exposure scenario. The following reasonable worst case potential hand exposures were derived from combined datasets: (i) loading and filling of large containers (or mixers) with large amounts (many litres) of liquids: 11,500 mg per scenario (14 mg cm(-2) per scenario with surface of the hands assumed to be 820 cm(2)); (ii) careful mixing of small quantities (tens of grams in <1l): 4.1 mg per scenario (0.005 mg cm(-2) per scenario); (iii) spreading of (viscous) liquids with a comb on a large surface area: 130 mg per scenario (0.16 mg cm(-2) per scenario); (iv) brushing and rolling of (relatively viscous) liquid products on surfaces: 6500 mg per scenario (8 mg cm(-2) per scenario) and (v) spraying large amounts of liquids (paints, cleaning products) on large areas: 12,000 mg per scenario (14 mg cm(-2) per scenario). These default values are considered useful for estimating exposure for similar substances in similar situations with low uncertainty. Several other default values based on single datasets can also be used, but lead to estimates with a higher uncertainty, due to their more limited basis. Sufficient analogy in all described parameters of the scenario, including duration, is needed to enable proper use of the default values. The default values lead to similar estimates as the RISKOFDERM dermal exposure model that was based on the same datasets, but uses very different parameters. Both approaches are preferred over older general models, such as EASE, that are not based on data from actual dermal exposure situations.

Probabilistic Tsunami Hazard Assessment: the Seaside, Oregon Pilot Study

NASA Astrophysics Data System (ADS)

Gonzalez, F. I.; Geist, E. L.; Synolakis, C.; Titov, V. V.

2004-12-01

A pilot study of Seaside, Oregon is underway, to develop methodologies for probabilistic tsunami hazard assessments that can be incorporated into Flood Insurance Rate Maps (FIRMs) developed by FEMA's National Flood Insurance Program (NFIP). Current NFIP guidelines for tsunami hazard assessment rely on the science, technology and methodologies developed in the 1970s; although generally regarded as groundbreaking and state-of-the-art for its time, this approach is now superseded by modern methods that reflect substantial advances in tsunami research achieved in the last two decades. In particular, post-1990 technical advances include: improvements in tsunami source specification; improved tsunami inundation models; better computational grids by virtue of improved bathymetric and topographic databases; a larger database of long-term paleoseismic and paleotsunami records and short-term, historical earthquake and tsunami records that can be exploited to develop improved probabilistic methodologies; better understanding of earthquake recurrence and probability models. The NOAA-led U.S. National Tsunami Hazard Mitigation Program (NTHMP), in partnership with FEMA, USGS, NSF and Emergency Management and Geotechnical agencies of the five Pacific States, incorporates these advances into site-specific tsunami hazard assessments for coastal communities in Alaska, California, Hawaii, Oregon and Washington. NTHMP hazard assessment efforts currently focus on developing deterministic, "credible worst-case" scenarios that provide valuable guidance for hazard mitigation and emergency management. The NFIP focus, on the other hand, is on actuarial needs that require probabilistic hazard assessments such as those that characterize 100- and 500-year flooding events. There are clearly overlaps in NFIP and NTHMP objectives. NTHMP worst-case scenario assessments that include an estimated probability of occurrence could benefit the NFIP; NFIP probabilistic assessments of 100- and 500-yr events could benefit the NTHMP. The joint NFIP/NTHMP pilot study at Seaside, Oregon is organized into three closely related components: Probabilistic, Modeling, and Impact studies. Probabilistic studies (Geist, et al., this session) are led by the USGS and include the specification of near- and far-field seismic tsunami sources and their associated probabilities. Modeling studies (Titov, et al., this session) are led by NOAA and include the development and testing of a Seaside tsunami inundation model and an associated database of computed wave height and flow velocity fields. Impact studies (Synolakis, et al., this session) are led by USC and include the computation and analyses of indices for the categorization of hazard zones. The results of each component study will be integrated to produce a Seaside tsunami hazard map. This presentation will provide a brief overview of the project and an update on progress, while the above-referenced companion presentations will provide details on the methods used and the preliminary results obtained by each project component.

Worst theft losses are for Mercedes model; 2 of 3 worst are for acura

DOT National Transportation Integrated Search

2000-05-13

The Highway Loss Data Institute's annual list of vehicles with worst theft losses has Mercedes S class heading the list of passenger vehicles with the highest insurance losses for theft. Overall losses for this car are 10 times higher than the averag...

Extensions of the Einstein-Schrodinger non-symmetric theory of gravity

NASA Astrophysics Data System (ADS)

Shifflett, James A.

We modify the Einstein-Schrödinger theory to include a cosmological constant L z which multiplies the symmetric metric. The cosmological constant L z is assumed to be nearly cancelled by Schrödinger's cosmological constant L b which multiplies the nonsymmetric fundamental tensor, such that the total L = L z + L b matches measurement. The resulting theory becomes exactly Einstein-Maxwell theory in the limit as |L z | [arrow right] oo. For |L z | ~ 1/(Planck length) 2 the field equations match the ordinary Einstein and Maxwell equations except for extra terms which are < 10 -16 of the usual terms for worst-case field strengths and rates-of-change accessible to measurement. Additional fields can be included in the Lagrangian, and these fields may couple to the symmetric metric and the electromagnetic vector potential, just as in Einstein-Maxwell theory. The ordinary Lorentz force equation is obtained by taking the divergence of the Einstein equations when sources are included. The Einstein- Infeld-Hoffmann (EIH) equations of motion match the equations of motion for Einstein-Maxwell theory to Newtonian/Coulombian order, which proves the existence of a Lorentz force without requiring sources. An exact charged solution matches the Reissner-Nordström solution except for additional terms which are ~ 10 -66 of the usual terms for worst-case radii accessible to measurement. An exact electromagnetic plane-wave solution is identical to its counterpart in Einstein-Maxwell theory. Peri-center advance, deflection of light and time delay of light have a fractional difference of < 10 -56 compared to Einstein-Maxwell theory for worst-case parameters. When a spin-1/2 field is included in the Lagrangian, the theory gives the ordinary Dirac equation, and the charged solution results in fractional shifts of < 10 -50 in Hydrogen atom energy levels. Newman-Penrose methods are used to derive an exact solution of the connection equations, and to show that the charged solution is Petrov type- D like the Reissner-Nordström solution. The Newman-Penrose asymptotically flat [Special characters omitted.] (1/ r 2 ) expansion of the field equations is shown to match Einstein-Maxwell theory. Finally we generalize the theory to non-Abelian fields, and show that a special case of the resulting theory closely approximates Einstein-Weinberg-Salam theory.

Impacts of fertilizer additions on water quality of a drained pine plantation in North Carolina. A worst case scenario.

Treesearch

Bray J. Beltran; Devendra M. Amatya; Martin Jones; R. Wayne Skaggs; William Neal P.E. Reynolds; Timothy J. Callahan; Jami E. Nettles

2008-01-01

Intensive plantation forestry will be increasingly important in the next 50 years to meet the high demand for domestic wood in the US. However, forestry management practices can substantially influence downstream water quality and ecology. In this study, the effect of fertilization on drainage water quality of a coastal pine plantation located in Carteret County, NC...

Impacts of fertilizer additions on water quality of a drained pine plantation in North Carolina. A worst case scenario.

Treesearch

Bray J. Beltran; Devendra M. Amatya; Martin Jones; R. Wayne Skaggs; William Neal Reynolds; Timothy J. Callahan; Jami E. Nettles

2008-01-01

Abstract. Intensive plantation forestry will be increasingly important in the next 50 years to meet the high demand for domestic wood in the US. However, forestry management practices can substantially influence downstream water quality and ecology. In this study, the effect of fertilization on drainage water quality of a coastal pine plantation located in Carteret...

Do Pupils with Differing Cognitive Abilities Benefit Similarly from a Self-Regulated Learning Training Program?

ERIC Educational Resources Information Center

Stoeger, Heidrun; Ziegler, Albert

2010-01-01

The inclusive education of the gifted is often met with skepticism. For example, it might be that gifted pupils are either under-challenged or excessive demands are placed on pupils with average abilities--and in the worst case, both. An alternative to handling this problem is presented by self-regulated learning which allows all students in the…

Preparing for the Worst-Case Scenario--Planning Pays Off with First-Ever Stadium Evacuation

ERIC Educational Resources Information Center

Bradley, Carol C.

2012-01-01

It's Saturday, September 3, Notre Dame vs. South Florida--the first home game of the season--and nearing halftime. The only person feeling more pressure than Head Coach Brian Kelly is Mike Seamon, associate vice president for campus safety and director of game day operations. Bad weather is on the way, and he's about to make the call to evacuate…

Ways through Which Principals Acquire the Leadership Competencies Required for Effective Management of Secondary Schools in Nairobi County, Kenya

ERIC Educational Resources Information Center

Githiari, Florence W.

2017-01-01

The last two decades have seen principals in Kenya come under heavy criticism over some serious cases of mismanagement that resulted in some of the worst institutional accidents, disasters/tragedies, unrests and even social and economic crimes that Kenya has witnessed. This study sought to find out ways that principals acquire the leadership…

E-Learning, Resilience and Change in Higher Education: Helping a University Cope after a Natural Disaster

ERIC Educational Resources Information Center

Ayebi-Arthur, Kofi

2017-01-01

This paper presents a case study of one College of Business (College of Business and Law from 2013) impacted in 2011 by earthquakes in New Zealand. Analyses from interviews of nine staff and documents were used to describe processes of increasing resilience with e-learning over the worst seismic events. Increasing deployment of the University's…

Cultivating Engineering Ethics and Critical Thinking: A Systematic and Cross-Cultural Education Approach Using Problem-Based Learning

ERIC Educational Resources Information Center

Chang, Pei-Fen; Wang, Dau-Chung

2011-01-01

In May 2008, the worst earthquake in more than three decades struck southwest China, killing more than 80,000 people. The complexity of this earthquake makes it an ideal case study to clarify the intertwined issues of ethics in engineering and to help cultivate critical thinking skills. This paper first explores the need to encourage engineering…

Level II scour analysis for Bridge 49 (BENNCYHUNT0049) on Hunt Street, crossing the Walloomsac River, Bennington, Vermont

USGS Publications Warehouse

Olson, Scott A.; Medalie, Laura

1997-01-01

2 stone fill also protects the channel banks upstream and downstream of the bridge for a minimum distance of 17 feet from the respective bridge faces. Additional details describing conditions at the site are included in the Level II Summary and Appendices D and E. Scour depths and recommended rock rip-rap sizes were computed using the general guidelines described in Hydraulic Engineering Circular 18 (Richardson and others, 1995). Total scour at a highway crossing is comprised of three components: 1) long-term streambed degradation; 2) contraction scour (due to accelerated flow caused by a reduction in flow area at a bridge) and; 3) local scour (caused by accelerated flow around piers and abutments). Total scour is the sum of the three components. Equations are available to compute depths for contraction and local scour and a summary of the results of these computations follows. Contraction scour computed for all modelled flows ranged from 0.9 to 5.0 ft. The worst-case contraction scour occurred at the 500-year discharge. Computed left abutment scour ranged from 15.3 to 16.5 ft. with the worst-case scour occurring at the incipient roadway-overtopping discharge. Computed right abutment scour ranged from 6.0 to 8.7 ft. with the worst-case scour occurring at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

15 CFR 335.3 - Applications to receive allocation.

Code of Federal Regulations, 2014 CFR

2014-01-01

... cut and sewed in the United States all three of the following apparel products: Worsted Wool Suits, Worsted Wool Suit-Type Jackets, and Worsted Wool Trousers. The applicant may either have cut and sewn... average fiber diameters of 18.5 microns or less, suitable for use in making suits, suit-type jackets, and...

15 CFR 335.3 - Applications to receive allocation.

Code of Federal Regulations, 2012 CFR

2012-01-01

... cut and sewed in the United States all three of the following apparel products: Worsted Wool Suits, Worsted Wool Suit-Type Jackets, and Worsted Wool Trousers. The applicant may either have cut and sewn... average fiber diameters of 18.5 microns or less, suitable for use in making suits, suit-type jackets, and...

15 CFR 335.3 - Applications to receive allocation.

Code of Federal Regulations, 2013 CFR

2013-01-01

... cut and sewed in the United States all three of the following apparel products: Worsted Wool Suits, Worsted Wool Suit-Type Jackets, and Worsted Wool Trousers. The applicant may either have cut and sewn... average fiber diameters of 18.5 microns or less, suitable for use in making suits, suit-type jackets, and...

15 CFR 335.3 - Applications to receive allocation.

Code of Federal Regulations, 2011 CFR

2011-01-01

... cut and sewed in the United States all three of the following apparel products: Worsted Wool Suits, Worsted Wool Suit-Type Jackets, and Worsted Wool Trousers. The applicant may either have cut and sewn... average fiber diameters of 18.5 microns or less, suitable for use in making suits, suit-type jackets, and...

15 CFR 335.3 - Applications to receive allocation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... cut and sewed in the United States all three of the following apparel products: Worsted Wool Suits, Worsted Wool Suit-Type Jackets, and Worsted Wool Trousers. The applicant may either have cut and sewn... average fiber diameters of 18.5 microns or less, suitable for use in making suits, suit-type jackets, and...

Design and modeling of a measuring device for a TIR-R concentrator

NASA Astrophysics Data System (ADS)

Calero, Daniel Pérez; Miñano, Juan Carlos; Benitez, Pablo; Hernandez, Maikel; Cvetkovic, Aleksandra

2006-08-01

One of the most usual procedures to measure a concentrator optical efficiency is by direct comparison between the photocurrent generated by the compound concentrator/solar cell and photocurrent that single cell would generate under identical radiation conditions. Unfortunately, such procedure can give a good idea of the generator final performance, but can not indicate the real amount of radiation that will impinge over the cell. This apparent contradiction is based on the fact that once the cell is coupled with the concentrator, rays incidence is not perpendicular, but highly oblique, with an angle that can reach 70 ° or even greater for high concentration devices. The antireflective coating of the cell does not perform well enough for the whole incidence angle and frequency ranges because low cost is other important requirement for the solar cells. In consequence, the generated photocurrent drops for large incidence angles. In our case, a 70% incidence angle could, in the worst case, mean a 34% loss on generated photocurrent. With the aim of correcting such problem a special device has been designed in the framework of a EU funded project called HAMLET. The concept of the device is to substitute the concentrator receptor by a system formed by an optical collimator that would reduce concentration and incidence angle, and a characterized solar cell. The paper gives the results of this measuring procedure.

Vulnerability and impact assessment of extreme climatic event: A case study of southern Punjab, Pakistan.

PubMed

Aslam, Abdul Qayyum; Ahmad, Sajid R; Ahmad, Iftikhar; Hussain, Yawar; Hussain, Muhammad Sameem

2017-02-15

Understanding of frequency, severity, damages and adaptation costs of climate extremes is crucial to manage their aftermath. Evaluation of PRECIS RCM modelled data under IPCC scenarios in Southern Punjab reveals that monthly mean temperature is 30°C under A2 scenario, 2.4°C higher than A1B which is 27.6°C in defined time lapses. Monthly mean precipitation under A2 scenario ranges from 12 to 15mm and for A1B scenario it ranges from 15 to 19mm. Frequency modelling of floods and droughts via poisson distribution shows increasing trend in upcoming decades posing serious impacts on agriculture and livestock, food security, water resources, public health and economic status. Cumulative loss projected for frequent floods without adaptation will be in the range of USD 66.8-79.3 billion in time lapse of 40years from 2010 base case. Drought damage function @ 18% for A2 scenario and @ 13.5% for A1B scenario was calculated; drought losses on agriculture and livestock sectors were modelled. Cumulative loss projected for frequent droughts without adaptation under A2 scenario will be in the range of USD 7.5-8.5 billion while under A1B scenario it will be in the range of USD 3.5-4.2 billion for time lapse of 60years from base case 1998-2002. Severity analysis of extreme events shows that situation get worse if adaptations are not only included in the policy but also in the integrated development framework with required allocation of funds. This evaluation also highlights the result of cost benefit analysis, benefits of the adaptation options (mean & worst case) for floods and droughts in Southern Punjab. Additionally the research highlights the role of integrated extreme events impact assessment methodology in performing the vulnerability assessments and to support the adaptation decisions. This paper is an effort to highlight importance of bottom up approaches to deal with climate change. Copyright © 2016 Elsevier B.V. All rights reserved.

The Mesaba Energy Project: Clean Coal Power Initiative, Round 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stone, Richard; Gray, Gordon; Evans, Robert

2014-07-31

The Mesaba Energy Project is a nominal 600 MW integrated gasification combine cycle power project located in Northeastern Minnesota. It was selected to receive financial assistance pursuant to code of federal regulations (?CFR?) 10 CFR 600 through a competitive solicitation under Round 2 of the Department of Energy?s Clean Coal Power Initiative, which had two stated goals: (1) to demonstrate advanced coal-based technologies that can be commercialized at electric utility scale, and (2) to accelerate the likelihood of deploying demonstrated technologies for widespread commercial use in the electric power sector. The Project was selected in 2004 to receive a totalmore » of $36 million. The DOE portion that was equally cost shared in Budget Period 1 amounted to about $22.5 million. Budget Period 1 activities focused on the Project Definition Phase and included: project development, preliminary engineering, environmental permitting, regulatory approvals and financing to reach financial close and start of construction. The Project is based on ConocoPhillips? E-Gas? Technology and is designed to be fuel flexible with the ability to process sub-bituminous coal, a blend of sub-bituminous coal and petroleum coke and Illinois # 6 bituminous coal. Major objectives include the establishment of a reference plant design for Integrated Gasification Combined Cycle (?IGCC?) technology featuring advanced full slurry quench, multiple train gasification, integration of the air separation unit, and the demonstration of 90% operational availability and improved thermal efficiency relative to previous demonstration projects. In addition, the Project would demonstrate substantial environmental benefits, as compared with conventional technology, through dramatically lower emissions of sulfur dioxide, nitrogen oxides, volatile organic compounds, carbon monoxide, particulate matter and mercury. Major milestones achieved in support of fulfilling the above goals include obtaining Site, High Voltage Transmission Line Route, and Natural Gas Pipeline Route Permits for a Large Electric Power Generating Plant to be located in Taconite, Minnesota. In addition, major pre-construction permit applications have been filed requesting authorization for the Project to i) appropriate water sufficient to accommodate its worst case needs, ii) operate a major stationary source in compliance with regulations established to protect public health and welfare, and iii) physically alter the geographical setting to accommodate its construction. As of the current date, the Water Appropriation Permits have been obtained.« less

When is best-worst best? A comparison of best-worst scaling, numeric estimation, and rating scales for collection of semantic norms.

PubMed

Hollis, Geoff; Westbury, Chris

2018-02-01

Large-scale semantic norms have become both prevalent and influential in recent psycholinguistic research. However, little attention has been directed towards understanding the methodological best practices of such norm collection efforts. We compared the quality of semantic norms obtained through rating scales, numeric estimation, and a less commonly used judgment format called best-worst scaling. We found that best-worst scaling usually produces norms with higher predictive validities than other response formats, and does so requiring less data to be collected overall. We also found evidence that the various response formats may be producing qualitatively, rather than just quantitatively, different data. This raises the issue of potential response format bias, which has not been addressed by previous efforts to collect semantic norms, likely because of previous reliance on a single type of response format for a single type of semantic judgment. We have made available software for creating best-worst stimuli and scoring best-worst data. We also made available new norms for age of acquisition, valence, arousal, and concreteness collected using best-worst scaling. These norms include entries for 1,040 words, of which 1,034 are also contained in the ANEW norms (Bradley & Lang, Affective norms for English words (ANEW): Instruction manual and affective ratings (pp. 1-45). Technical report C-1, the center for research in psychophysiology, University of Florida, 1999).

77 FR 70473 - Child Labor, Forced Labor, and Forced or Indentured Child Labor in the Production of Goods in...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-26

... Production of Goods in Foreign Countries and Efforts by Certain Countries To Eliminate the Worst Forms of...'s individual advancement toward eliminating the worst forms of child labor during the current... beneficiary country's implementation of its international commitments to eliminate the worst forms of child...

Reliability Practice at NASA Goddard Space Flight Center

NASA Technical Reports Server (NTRS)

Pruessner, Paula S.; Li, Ming

2008-01-01

This paper describes in brief the Reliability and Maintainability (R&M) Programs performed directly by the reliability branch at Goddard Space Flight Center (GSFC). The mission assurance requirements flow down is explained. GSFC practices for PRA, reliability prediction/fault tree analysis/reliability block diagram, FMEA, part stress and derating analysis, worst case analysis, trend analysis, limit life items are presented. Lessons learned are summarized and recommendations on improvement are identified.

Natural Hazards Observer. Volume 32, Number 2, November 2007

DTIC Science & Technology

2007-11-01

global warming plan that proposed an obligatory, market -based, cap-and-trade pro- gram that would reverse the worst-case effects of climate change by... market penetration for flood insurance, building Report (under Goal 4: "Lofty Targets"). and elevation requirements, hazard mitigation grants, The Report...reinsurance markets in subsequent years. With an unbiased perspective of all catastrophe model- 8th Pacific Conference on Earthquake Engineering-Sin- ing

Preparing for the Worst: Psychological Excellence of First Responders - A Katrina Lessons Learned Study

DTIC Science & Technology

2008-01-01

cases on human cognition and performance. For instance, when you learn to fly an airplane, you will be instructed to use a simple rule to avoid...Existing Training Technologies; First Responders; Katrina; Lesson Learned 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER... student . Based in Maryland, the training institute prepares first responders using online learning courses or training exercises. Such topics

A Roadmap for Future Security in the Western Balkans

DTIC Science & Technology

2012-03-22

and a specific cultural ambience.”5 In its historical background, the Balkan region was full of lasting frictions and security dilemmas. Probably...full moral , political, and diplomatic authority in a coherent and consistent way.”45 Although the EU has made a lot of organizational and... moral and pragmatic reasons toward the Western Balkan crisis in order to prevent the worst case scenario: escalating conflicts in Europe, and the

Draft Environmental Impact Statement-Consolidated Space Operations Center.

DTIC Science & Technology

1980-10-01

about 10 in the human resonance (worst case) region of the electromagnetic spectrum. The USAF has a significant Radiofrequency Radiation (RFR...accessis necessary. I 3. Restrict all air traffic within 1000 feet of the antenna - field to avoid possible exposure of electroexplosive de- vices to...Permissible Exposure Level (MPEL) for occupational personnel is 10 mw/cm 2 and is based on past knowledge of radiofrequency radiation effects (Ref

TID and SEE Response of an Advanced Samsung 4G NAND Flash Memory

NASA Technical Reports Server (NTRS)

Oldham, Timothy R.; Friendlich, M.; Howard, J. W.; Berg, M. D.; Kim, H. S.; Irwin, T. L.; LaBel, K. A.

2007-01-01

Initial total ionizing dose (TID) and single event heavy ion test results are presented for an unhardened commercial flash memory, fabricated with 63 nm technology. Results are that the parts survive to a TID of nearly 200 krad (SiO2), with a tractable soft error rate of about 10(exp -l2) errors/bit-day, for the Adams Ten Percent Worst Case Environment.

A Risk-Based Approach to Variable Load Configuration Validation in Steam Sterilization: Application of PDA Technical Report 1 Load Equivalence Topic.

PubMed

Pavell, Anthony; Hughes, Keith A

2010-01-01

This article describes a method for achieving the load equivalence model, described in Parenteral Drug Association Technical Report 1, using a mass-based approach. The item and load bracketing approach allows for mixed equipment load size variation for operational flexibility along with decreased time to introduce new items to the operation. The article discusses the utilization of approximately 67 items/components (Table IV) identified for routine sterilization with varying quantities required weekly. The items were assessed for worst-case identification using four temperature-related criteria. The criteria were used to provide a data-based identification of worst-case items, and/or item equivalence, to carry forward into cycle validation using a variable load pattern. The mass approach to maximum load determination was used to bracket routine production use and allows for variable loading patterns. The result of the item mapping and load bracketing data is "a proven acceptable range" of sterilizing conditions including loading configuration and location. The application of these approaches, while initially more time/test-intensive than alternate approaches, provides a method of cycle validation with long-term benefit of ease of ongoing qualification, minimizing time and requirements for new equipment qualification for similar loads/use, and for rapid and rigorous assessment of new items for sterilization.