[The waterpipe (shisha) - indoor air quality, human biomonitoring, and health effects].

PubMed

Fromme, Hermann; Schober, Wolfgang

2016-12-01

Waterpipe (WP) smoking, also known as shisha or hookah smoking, is growing in western countries as an alternative to cigarette smoking, especially in younger age groups. A majority of smokers mistakenly believe that shisha smoking is a social entertainment practice that leads to more social behavior and relaxation and that this type of smoking is safe or less harmful and less addictive than cigarette smoking.In reality, WP smokers are exposed to hundreds of toxic substances that include well-known carcinogens. High exposures to carbon monoxide and nicotine are major health threats. There is growing evidence that WP smoke causes adverse effects on the pulmonary and cardiovascular systems and there are indications that WP smoke is associated with cancer. Persons exposed to secondhand WP smoke are also at risk.More research on the health effects of WP is urgently needed and more preventive measures for public health protection. Moreover, public WP facilities should be implemented under specific nonsmoker protection laws and consequently controlled.This review summarizes recent data on exposure to WP smoking in indoor environments, the results of biomonitoring data, and the known health effects based on currently available toxicological or epidemiological studies.

Effect of whey protein supplementation on body composition changes in women: a systematic review and meta-analysis.

PubMed

Bergia, Robert E; Hudson, Joshua L; Campbell, Wayne W

2018-04-23

A preponderance of evidence supports the beneficial effects of whey protein (WP) supplementation on body composition in men; however, there is currently insufficient evidence to make an equivalent claim in women. This systematic review and meta-analysis assessed the effects of WP supplementation with or without energy restriction (ER) and resistance training (RT) on changes in body mass, lean mass, and fat mass in women. Pubmed, Scopus, Cochrane, and CINAHL were searched using the keywords "whey protein," "body composition," and "lean mass." Two researchers independently screened 1845 abstracts and extracted 276 articles. Thirteen randomized controlled trials with 28 groups met the inclusion criteria. Globally, WP supplementation increased lean mass (WMD, 0.37 kg; 95% confidence interval [CI], 0.06 to 0.67) while not influencing changes in fat mass (-0.20 kg; 95%CI, -0.67 to 0.27) relative to non-WP control. The beneficial effect of WP on lean mass was lost when only studies with RT were included in the analysis (n = 7 comparisons; 0.23 kg; 95%CI, -0.17 to 0.63). The beneficial effect of WP on lean mass was more robust when only studies with an ER component were included (n = 6 comparisons; 0.90 kg; 95%CI, 0.31 to 1.49). There was no effect of WP on lean mass in studies without ER (n = 9 comparisons; 0.22 kg; 95%CI, -0.12 to 0.57). Whey protein supplementation improves body composition by modestly increasing lean mass without influencing changes in fat mass. Body composition improvements from WP are more robust when combined with ER .

A Novel Inhibitor of STAT3 Activation Is Efficacious Against Established Central Nervous System Melanoma and Inhibits Regulatory T Cells

PubMed Central

Kong, Ling-Yuan; Abou-Ghazal, Mohamed K.; Wei, Jun; Chakraborty, Arup; Sun, Wei; Qiao, Wei; Fuller, Gregory N.; Fokt, Izabela; Grimm, Elizabeth A.; Schmittling, Robert J.; Archer, Gary E.; Sampson, John H.; Priebe, Waldemar; Heimberger, Amy B.

2008-01-01

Purpose Activation of STAT3 has been identified as a central mediator of melanoma growth and metastasis. We hypothesized that WP1066, a novel STAT3 blockade agent, has marked antitumor activity, even against the melanoma metastasis to brain, a site typically refractory to therapies. Experimental Design The antitumor activities and related mechanisms of WP1066 were investigated both in vitro on melanoma cell lines and in vivo on mice with subcutaneously syngeneic melanoma or with intracerebral melanoma tumors. Results WP1066 achieved an IC50 of 1.6 μM, 2.3 μM, and 1.5 μM against melanoma cell line A375, B16 and B16EGFRvIII, respectively. WP1066 suppressed the phosphorylation of JAK2 and STAT3 (Tyr705) in these cells. Tumor growth in mice with subcutaneously established syngeneic melanoma was markedly inhibited by WP1066 compared with that in controls. Long-term survival (>78 days) was observed in 80% of mice with established intracerebral syngeneic melanoma treated with 40 mg/kg of WP1066 in contrast to control mice who survived for a median of 15 days. Although WP1066 did not induce immunological memory or enhance humoral responses to EGFRvIII, this compound reduced the production of immunosuppressive cytokines and chemokines (TGF-β, RANTES, MCP-1, VEGF), markedly inhibited natural and inducible Treg proliferation, and significantly increased cytotoxic immune responses of T cells. Conclusions The antitumor cytotoxic effects of WP1066 and its ability to induce antitumor immune responses suggest that this compound has potential for the effective treatment of melanoma metastatic to brain. PMID:18794085

The pecan nut (Carya illinoinensis) and its oil and polyphenolic fractions differentially modulate lipid metabolism and the antioxidant enzyme activities in rats fed high-fat diets.

PubMed

Domínguez-Avila, Jesús A; Alvarez-Parrilla, Emilio; López-Díaz, José A; Maldonado-Mendoza, Ignacio E; Gómez-García, María Del Consuelo; de la Rosa, Laura A

2015-02-01

Tree nuts such as pecans (Carya illinoinensis) contain mostly oil but are also a source of polyphenols. Nut consumption has been linked to a reduction in serum lipid levels and oxidative stress. These effects have been attributed to the oil while overlooking the potential contribution of the polyphenols. Because the evidence regarding each fraction's bioactivity is scarce, we administered high-fat (HF) diets to male Wistar rats, supplementing them with pecan oil (HF+PO), pecan polyphenols (HF+PP) or whole pecans (HF+WP), and analysed the effects of each fraction. The HF diet increased the serum leptin and total cholesterol (TC) with respect to the control levels. The HF+WP diet prevented hyperleptinemia and decreased the TC compared with the control. The HF+WP diet upregulated the hepatic expression of apolipoprotein B and LDL receptor mRNAs with respect to the HF levels. The HF+PO diet reduced the level of triacylglycerols compared with the control. The HF+PP diet stimulated the hepatic expression of liver X receptor alpha mRNA. The HF+WP diet increased the activities of hepatic catalase, glutathione peroxidase and glutathione S transferase compared with the control, and decreased the degree of lipid peroxidation compared with the HF diet. The most bioactive diet was the WP diet. Copyright © 2014 Elsevier Ltd. All rights reserved.

Whey protein hydrolysates decrease IL-8 secretion in lipopolysaccharide (LPS)-stimulated respiratory epithelial cells by affecting LPS binding to Toll-like receptor 4.

PubMed

Iskandar, Michèle M; Dauletbaev, Nurlan; Kubow, Stan; Mawji, Nadir; Lands, Larry C

2013-07-14

Whey proteins (WP) exert anti-inflammatory and antioxidant effects. Hyperbaric pressurisation of whey increases its digestibility and changes the spectrum of peptides released during digestion. We have shown that dietary supplementation with pressurised whey improves nutritional status and systemic inflammation in patients with cystic fibrosis (CF). Both clinical indices are largely affected by airway processes, to which respiratory epithelial cells actively contribute. Here, we tested whether peptides released from the digestion of pressurised whey can attenuate the inflammatory responses of CF respiratory epithelial cells. Hydrolysates of pressurised WP (pWP) and native WP (nWP, control) were generated in vitro and tested for anti-inflammatory properties judged by the suppression of IL-8 production in CF and non-CF respiratory epithelial cell lines (CFTE29o- and 1HAEo-, respectively). We observed that, in both cell lines, pWP hydrolysate suppressed IL-8 production stimulated by lipopolysaccharide (LPS) to a greater magnitude compared with nWP hydrolysate. Neither hydrolysate suppressed IL-8 production induced by TNF-α or IL-1β, suggesting an effect on the Toll-like receptor (TLR) 4 pathway, the cellular sensor for LPS. Further, neither hydrolysate affected TLR4 expression or neutralised LPS. Both pWP and nWP hydrolysates similarly reduced LPS binding to surface TLR4, while pWP tended to more potently increase extracellular antioxidant capacity. (1) anti-inflammatory properties of whey are enhanced by pressurisation; (2) suppression of IL-8 production may contribute to the clinical effects of pressurised whey supplementation on CF; (3) this effect may be partly explained by a combination of reduced LPS binding to TLR4 and enhanced extracellular antioxidant capacity.

Is Word-Problem Solving a Form of Text Comprehension?

PubMed Central

Fuchs, Lynn S.; Fuchs, Douglas; Compton, Donald L.; Hamlett, Carol L.; Wang, Amber Y.

2015-01-01

This study’s hypotheses were that (a) word-problem (WP) solving is a form of text comprehension that involves language comprehension processes, working memory, and reasoning, but (b) WP solving differs from other forms of text comprehension by requiring WP-specific language comprehension as well as general language comprehension. At the start of the 2nd grade, children (n = 206; on average, 7 years, 6 months) were assessed on general language comprehension, working memory, nonlinguistic reasoning, processing speed (a control variable), and foundational skill (arithmetic for WPs; word reading for text comprehension). In spring, they were assessed on WP-specific language comprehension, WPs, and text comprehension. Path analytic mediation analysis indicated that effects of general language comprehension on text comprehension were entirely direct, whereas effects of general language comprehension on WPs were partially mediated by WP-specific language. By contrast, effects of working memory and reasoning operated in parallel ways for both outcomes. PMID:25866461

A Description of the Framework of the Atmospheric Boundary Layer Environment (ABLE) Model

DTIC Science & Technology

2012-09-01

difference scheme (CDS). For the mass flux through the face e of CV, mUDSe CDS e UDS ee QQQQ )(  . (16) The superscript m again means that...PEPee xr  , zyCUQ EEE   , and the lowercase subscripts represents the advective fluxes at the corresponding faces of control volume...WP wW PE eE WP WP wPwW PE PE eEeP we we xx zyD FC xx zyD

Control of accidental releases of hydrogen selenide in vented storage cabinets

NASA Astrophysics Data System (ADS)

Fthenakis, V. M.; Moskowitz, P. D.; Sproull, R. D.

1988-07-01

Highly toxic hydrogen selenide and hydrogen sulfide gases are used in the production of copper-indium-diselenide photovoltaic cells by reactive sputtering. In the event of an accident, these gases may be released to the atmosphere and pose hazards to public and occupational safety and health. This paper outlines an approach for designing systems for the control of these releases given the uncertainty in release conditions and lack of data on the chemical systems involved. Accidental releases of these gases in storage cabinets can be controlled by either a venturi and packed-bed scrubber and carbon adsorption bed, or containment scrubbing equipment followed by carbon adsorption. These systems can effectively reduce toxic gas emissions to levels needed to protect public health. The costs of these controls (˜0.012/Wp) are samll in comparison with current (˜6/Wp) and projected (˜I/Wp) production costs.

Plasma rich in growth factors (PRGF-Endoret) stimulates corneal wound healing and reduces haze formation after PRK surgery.

PubMed

Anitua, E; Muruzabal, F; Alcalde, I; Merayo-Lloves, J; Orive, G

2013-10-01

This study evaluated the efficacy of Plasma rich in growth factors (PRGF-Endoret) on the corneal wound healing process after Photorefractive keratectomy (PRK). To address this, blood from three healthy donors was collected, centrifuged and, the whole plasma column (WP) and the plasma fraction with the highest platelet concentration (F3) were collected. The effects of F3 and WP on the proliferation and migration of human corneal epithelial cells (HCE) were analyzed. PRK was performed on C57BL/6 mice. Animals were divided in three treatment groups: Control, F3, and WP. Corneal wound healing and haze formation were evaluated macroscopically. Eyes were collected at 1, 2, 3, and 7 days after surgery, and were processed for histological studies. Immunofluorescence was used to assess cellular proliferation, apoptosis and myofibroblast transformation in the mouse cornea. Results showed a significant increased on proliferation and wound healing after F3 and WP treatment when compared with control group. In vivo studies showed significant reduction on haze formation in mice treated with both PRGF-Endoret formulations (F3 and WP). Histological studies showed an increase of epithelial cell proliferation in corneas of control group, promoting an epithelial hyperplasia. The number of SMA-positive cells (corresponding to myofibroblast differentiation) was significantly lower in the PRGF-Endoret group than in the control group, correlating with the higher transparence results observed macroscopically in both PRGF-Endoret groups. According to this, it can be concluded that PRGF-Endoret accelerates corneal tissue regeneration after PRK, reducing haze formation. Copyright © 2013 Elsevier Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Silva, R.A.; Cron, J.

This design analysis has shown that, on a conceptual level, the emplacement of drip shields is feasible with current technology and equipment. A plan for drip shield emplacement was presented using a Drip Shield Transporter, a Drip Shield Emplacement Gantry, a locomotive, and a Drip Shield Gantry Carrier. The use of a Drip Shield Emplacement Gantry as an emplacement concept results in a system that is simple, reliable, and interfaces with the numerous other exising repository systems. Using the Waste Emplacement/Retrieval System design as a basis for the drip shield emplacement concept proved to simplify the system by using existingmore » equipment, such as the gantry carrier, locomotive, Electrical and Control systems, and many other systems, structures, and components. Restricted working envelopes for the Drip Shield Emplacement System require further consideration and must be addressed to show that the emplacement operations can be performed as the repository design evolves. Section 6.1 describes how the Drip Shield Emplacement System may use existing equipment. Depending on the length of time between the conclusion of waste emplacement and the commencement of drip shield emplacement, this equipment could include the locomotives, the gantry carrier, and the electrical, control, and rail systems. If the exisiting equipment is selected for use in the Drip Shield Emplacement System, then the length of time after the final stages of waste emplacement and start of drip shield emplacement may pose a concern for the life cycle of the system (e.g., reliability, maintainability, availability, etc.). Further investigation should be performed to consider the use of existing equipment for drip shield emplacement operations. Further investigation will also be needed regarding the interfaces and heat transfer and thermal effects aspects. The conceptual design also requires further design development. Although the findings of this analysis are accurate for the assumptions made, further refinements of this analysis are needed as the project parameters change. The designs of the drip shield, the Emplacement Drift, and the other drip shield emplacement equipment all have a direct effect on the overall design feasibility.« less

Effects of Whey, Caseinate, or Milk Protein Ingestion on Muscle Protein Synthesis after Exercise

PubMed Central

Kanda, Atsushi; Nakayama, Kyosuke; Sanbongi, Chiaki; Nagata, Masashi; Ikegami, Shuji; Itoh, Hiroyuki

2016-01-01

Whey protein (WP) is characterized as a “fast” protein and caseinate (CA) as a “slow” protein according to their digestion and absorption rates. We hypothesized that co-ingestion of milk proteins (WP and CA) may be effective for prolonging the muscle protein synthesis response compared to either protein alone. We therefore compared the effect of ingesting milk protein (MP) to either WP or CA alone on muscle protein synthesis after exercise in rats. We also compared the effects of these milk-derived proteins to a control, soy protein (SP). Male Sprague-Dawley rats swam for two hours. Immediately after exercise, one of the following four solutions was administered: WP, CA, MP, or SP. Individual rats were euthanized at designated postprandial time points and triceps muscle samples collected for measurement of the protein fractional synthesis rate (FSR). FSR tended to increase in all groups post-ingestion, although the initial peaks of FSR occurred at different times (WP, peak time = 60 min, FSR = 7.76%/day; MP, peak time = 90 min, FSR = 8.34%/day; CA, peak time = 120 min, FSR = 7.85%/day). Milk-derived proteins caused significantly greater increases (p < 0.05) in FSR compared with SP at different times (WP, 60 min; MP, 90 and 120 min; CA, 120 min). Although statistical analysis could not be performed, the calculated the area under the curve (AUC) values for FSR following this trend were: MP, 534.61; CA, 498.22; WP, 473.46; and SP, 406.18. We conclude that ingestion of MP, CA or WP causes the initial peak time in muscle protein synthesis to occur at different times (WP, fast; MP, intermediate; CA, slow) and the dairy proteins have a superior effect on muscle protein synthesis after exercise compared with SP. PMID:27271661

Effects of Whey, Caseinate, or Milk Protein Ingestion on Muscle Protein Synthesis after Exercise.

PubMed

Kanda, Atsushi; Nakayama, Kyosuke; Sanbongi, Chiaki; Nagata, Masashi; Ikegami, Shuji; Itoh, Hiroyuki

2016-06-03

Whey protein (WP) is characterized as a "fast" protein and caseinate (CA) as a "slow" protein according to their digestion and absorption rates. We hypothesized that co-ingestion of milk proteins (WP and CA) may be effective for prolonging the muscle protein synthesis response compared to either protein alone. We therefore compared the effect of ingesting milk protein (MP) to either WP or CA alone on muscle protein synthesis after exercise in rats. We also compared the effects of these milk-derived proteins to a control, soy protein (SP). Male Sprague-Dawley rats swam for two hours. Immediately after exercise, one of the following four solutions was administered: WP, CA, MP, or SP. Individual rats were euthanized at designated postprandial time points and triceps muscle samples collected for measurement of the protein fractional synthesis rate (FSR). FSR tended to increase in all groups post-ingestion, although the initial peaks of FSR occurred at different times (WP, peak time = 60 min, FSR = 7.76%/day; MP, peak time = 90 min, FSR = 8.34%/day; CA, peak time = 120 min, FSR = 7.85%/day). Milk-derived proteins caused significantly greater increases (p < 0.05) in FSR compared with SP at different times (WP, 60 min; MP, 90 and 120 min; CA, 120 min). Although statistical analysis could not be performed, the calculated the area under the curve (AUC) values for FSR following this trend were: MP, 534.61; CA, 498.22; WP, 473.46; and SP, 406.18. We conclude that ingestion of MP, CA or WP causes the initial peak time in muscle protein synthesis to occur at different times (WP, fast; MP, intermediate; CA, slow) and the dairy proteins have a superior effect on muscle protein synthesis after exercise compared with SP.

Identifying Behavioral Measures of Stress in Individuals with Aphasia

ERIC Educational Resources Information Center

Laures-Gore, Jacqueline S.; DuBay, Michaela F.; Duff, Melissa C.; Buchanan, Tony W.

2010-01-01

Purpose: To develop valid indicators of stress in individuals with aphasia (IWA) by examining the relationship between certain language variables (error frequency [EF] and word productivity [WP]) and cortisol reactivity. Method: Fourteen IWA and 10 controls participated in a speaking task. Salivary cortisol was collected pre- and posttask. WP and…

Different proteins and biopeptides differently affect satiety and anorexigenic/orexigenic hormones in healthy humans.

PubMed

Diepvens, K; Häberer, D; Westerterp-Plantenga, M

2008-03-01

We investigated the effects of whey protein (WP), pea protein hydrolysate (PPH), a combination of WP+PPH and control (milk protein (MP) which consists of 80% casein and 20% WP) on appetite ratings, postprandial changes in hunger/satiety hormones and energy intake (EI). A randomized, crossover design which consisted of 2 parts (experiment 1 and 2). The peptides to be tested were provided as part of a shake (1024 kJ; en% P/F/C: 25/33/42) which contained either 15 g WP, 15 g PPH, a combination of 7.5 g WP and 7.5 g PPH (WP+PPH) or 15 g MP. 39 subjects (BMI: 27.6+/-1.7 kg m(-2); age: 42.3+/-13.8 years). In experiment 1 (duration 4 h), appetite profile was measured and blood samples were taken for analysis of hunger/satiety hormones and glucose. In experiment 2 (duration 7 h), appetite profile and EI (180 min after consumption of the shake) were measured. Some indications of lower hunger (experiment 1), desire to eat (experiment 2) and thirst (experiment 1 and 2) were shown after consumption of PPH compared to MP or WP+PPH (P<0.05). A longer intermeal interval and a higher satiety index were suggested after consumption of PPH. Both PPH and WP lead to greater satiety (experiment 2) and fullness (experiment 2) compared to MP and WP+PPH (P<0.05). For WP, a positive correlation between insulin and both cholecystokinine (CCK) and glucagon like peptide-1 (GLP-1) was observed (P<0.05). However, both CCK and GLP-1 were increased by MP (P<0.05), peptide YY (PYY) was stimulated by WP+PPH, while the decline in ghrelin was larger (P<0.05). No effect on EI was seen. There was modest evidence with respect to satiety by PPH consumption. Different exogenous biopeptides produced differences in release of endogenous peptides that had inconsistent relationships with satiety. Therefore, evidence derived from a supposed biomarker for satiety does not guarantee the highest satiety.

An In vitro Study of Bio-Control and Plant Growth Promotion Potential of Salicaceae Endophytes.

PubMed

Kandel, Shyam L; Firrincieli, Andrea; Joubert, Pierre M; Okubara, Patricia A; Leston, Natalie D; McGeorge, Kendra M; Mugnozza, Giuseppe S; Harfouche, Antoine; Kim, Soo-Hyung; Doty, Sharon L

2017-01-01

Microbial communities in the endosphere of Salicaceae plants, poplar ( Populus trichocarpa ) and willow ( Salix sitchensis ), have been demonstrated to be important for plant growth promotion, protection from biotic and abiotic stresses, and degradation of toxic compounds. Our study aimed to investigate bio-control activities of Salicaceae endophytes against various soil borne plant pathogens including Rhizoctonia solani AG-8, Fusarium culmorum, Gaeumannomyces graminis var. tritici , and Pythium ultimum . Additionally, different plant growth promoting traits such as biological nitrogen fixation (BNF), indole-3-acetic acid (IAA) biosynthesis, phosphate solubilization, and siderophore production were assessed in all bio-control positive strains. Burkholderia, Rahnella, Pseudomonas , and Curtobacterium were major endophyte genera that showed bio-control activities in the in-vitro assays. The bio-control activities of Burkholderia strains were stronger across all tested plant pathogens as compared to other stains. Genomes of sequenced Burkholderia strains WP40 and WP42 were surveyed to identify the putative genes involved in the bio-control activities. The ocf and hcnABC gene clusters responsible for biosynthesis of the anti-fungal metabolites, occidiofungin and hydrogen cyanide, are present in the genomes of WP40 and WP42. Nearly all endophyte strains showing the bio-control activities produced IAA, solubilized tricalcium phosphate, and synthesized siderophores in the culture medium. Moreover, some strains reduced acetylene into ethylene in the acetylene reduction assay, a common assay used for BNF. Salicaceae endophytes could be useful for bio-control of various plant pathogens, and plant growth promotion possibly through the mechanisms of BNF, IAA production, and nutrient acquisition.

Effect of Surround WP on behavior and mortality of apple maggot (Diptera: Tephritidae).

PubMed

Leskey, Tracy C; Wright, Starker E; Glenn, D Michael; Puterka, Gary J

2010-04-01

Apple maggot, Rhagoletis pomonella (Walsh) (Diptera: Tephritidae), is a key pest in apple (Malus spp.) production areas located in the northeastern and midwestern United States and the eastern provinces of Canada. The development of Surround WP has offered a new approach for controlling apple maggot and other tephritid species, because this material is considered to be compatible with advanced integrated pest management and organic production systems. We conducted studies aimed at identifying the behavioral and biological effects of this material on apple maggots. Specifically, we examined the effect of Surround WP on the visual ecology of adult flies under field conditions, on tactile responses of flies in semifield trials, and on fly mortality in laboratory-based-bioassays. We demonstrated that an even coating of white particles over a fruit-mimicking sphere surface reduced visual attractiveness. We also found that spotty-coated fruit-mimicking spheres (meant to mimic ripe fruit bearing an uneven coating of Surround WP) were perceived by flies as not having the ideal round silhouette shape stimulus. Surround WP served as a tactile deterrent; the residence time of females introduced on to treated fruit was much shorter compared with untreated fruit. Surround WP also had a toxic effect on both adult apple maggot and Rhagoletis suavis (Loew); flies exposed to and forced to stand on Surround-treated surfaces died in <2 d in all trials. The combined effectiveness of Surround WP is based on a reduction in the attractiveness of fruit-based visual cues, an increase in the likelihood of flies leaving treated surfaces due to tactile deterrence, and a potential for increased mortality due to exposure to Surround WP particles.

EQ6 Calculation for Chemical Degradation of Shippingport LWBR (TH/U Oxide) Spent Nuclear Fuel Waste Packages

DOE Office of Scientific and Technical Information (OSTI.GOV)

S. Arthur

The Monitored Geologic Repository (MGR) Waste Package Department of the Civilian Radioactive Waste Management System Management & Operating contractor (CRWMS M&O) performed calculations to provide input for disposal of spent nuclear fuel (SNF) from the Shippingport Light Water Breeder Reactor (LWBR) (Ref. 1). The Shippingport LWBR SNF has been considered for disposal at the potential Yucca Mountain site. Because of the high content of fissile material in the SNF, the waste package (WP) design requires special consideration of the amount and placement of neutron absorbers and the possible loss of absorbers and SNF materials over geologic time. For some WPs,more » the outer shell corrosion-resistant material (CRM) and the corrosion-allowance inner shell may breach (Refs. 2 and 3), allowing the influx of water. Water in the WP will moderate neutrons, increasing the likelihood of a criticality event within the WP; and the water may, in time, gradually leach the fissile components and neutron absorbers from the WP, further affecting the neutronics of the system. This study presents calculations of the long-term geochemical behavior of WPs containing a Shippingport LWBR SNF seed assembly, and high-level waste (HLW) glass canisters arranged according to the codisposal concept (Ref. 4). The specific study objectives were to determine: (1) The extent to which criticality control material, suggested for this WP design, will remain in the WP after corrosion/dissolution of the initial WP configuration (such that it can be effective in preventing criticality); (2) The extent to which fissile uranium and fertile thorium will be carried out of the degraded WP by infiltrating water (such that internal criticality is no longer possible, but the possibility of external criticality may be enhanced); and (3) The nominal chemical composition for the criticality evaluations of the WP design, and to suggest the range of parametric variations for additional evaluations. The scope of this calculation, the chemical compositions (and subsequent criticality evaluations), of the simulations are limited to time periods up to 3.17 x 10{sup 5} years. This longer time frame is closer to the one million year time horizon recently recommended by the National Academy of Sciences to the Environmental Protection Agency for performance assessment related to a nuclear repository (Ref. 5). However, it is important to note that after 100,000 years, most of the materials of interest (fissile and absorber materials) will have either been removed from the WP, reached a steady state, or been transmuted. The calculation included elements with high neutron-absorption cross sections, notably gadolinium (Gd), as well as the fissile materials. The results of this analysis will be used to ensure that the type and amount of criticality control material used in the WP design will prevent criticality.« less

Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells.

PubMed

Lee, Hsueh-Te; Xue, Jianfei; Chou, Ping-Chieh; Zhou, Aidong; Yang, Phillip; Conrad, Charles A; Aldape, Kenneth D; Priebe, Waldemar; Patterson, Cam; Sawaya, Raymond; Xie, Keping; Huang, Suyun

2015-04-30

Brain metastasis is a major cause of morbidity and mortality in patients with breast cancer. Our previous studies indicated that Stat3 plays an important role in brain metastasis. Here, we present evidence that Stat3 functions at the level of the microenvironment of brain metastases. Stat3 controlled constitutive and inducible VEGFR2 expression in tumor-associated brain endothelial cells. Furthermore, inhibition of Stat3 by WP1066 decreased the incidence of brain metastases and increased survival in a preclinical model of breast cancer brain metastasis. WP1066 inhibited Stat3 activation in tumor-associated endothelial cells, reducing their infiltration and angiogenesis. WP1066 also inhibited breast cancer cell invasion. Our results indicate that WP1066 can inhibit tumor angiogenesis and brain metastasis mediated by Stat3 in endothelial and tumor cells.

The role of Toll-like receptor-4 in pertussis vaccine-induced immunity

PubMed Central

Banus, Sander; Stenger, Rachel M; Gremmer, Eric R; Dormans, Jan AMA; Mooi, Frits R; Kimman, Tjeerd G; Vandebriel, Rob J

2008-01-01

Background The gram-negative bacterium Bordetella pertussis is an important causative agent of pertussis, an infectious disease of the respiratory tract. After introduction of whole-cell vaccines (wP) in the 1950's, pertussis incidence has decreased significantly. Because wP were found to be reactogenic, in most developed countries they have been replaced by acellular vaccines (aP). We have previously shown a role for Toll-like receptor 4 (Tlr4) in pertussis-infected mice and the pertussis toxin (Ptx)-IgG response in wP-vaccinated children, raising the issue of the relative importance of Tlr4 in wP vaccination of mice. Here we analyze the effects of wP and aP vaccination and B. pertussis challenge, in Tlr4-deficient C3H/HeJ and wild-type C3H/HeOuJ mice. aP consists of Ptx, filamentous hemagglutinin (FHA), and pertactin (Prn). Results We show an important role of Tlr4 in wP and (to a lesser extent) aP vaccination, induction of Th1 and Th17 cells by wP but not aP vaccination, and induction of Th17 cells by infection, confirming data by Higgins et al. (J Immunol 2006, 177:7980–9). Furthermore, in Tlr4-deficient mice, compared to wild-type controls (i) after vaccination only, Ptx-IgG (that was induced by aP but not wP vaccination), FHA-IgG, and Prn-IgG levels were similar, (ii) after infection (only), lung IL-1α and IL-1β expression were lower, (iii) after wP vaccination and challenge, Prn-IgG level and lung IL-5 expression were higher, while lung IL-1β, TNF-α, IFN-γ, IL-17, and IL-23 expression were lower, and lung pathology was absent, and (iv) after aP vaccination and challenge, Prn-IgG level and lung IL-5 expression were higher, while Ptx-IgG level was lower. Conclusion Tlr4 does not influence the humoral response to vaccination (without challenge), plays an important role in natural immunity, wP and aP efficacy, and induction of Th1 and Th17 responses, is critical for lung pathology and enhances pro-inflammatory cytokine production after wP vaccination and challenge, and diminishes Th2 responses after both wP and aP vaccination and challenge. wP vaccination does not induce Ptx-IgG. A role for LPS in the efficacy of wP underlines the usefulness of LPS analogs to improve bacterial subunit vaccines such as aP. PMID:18498620

Genetic variation in susceptibility to fusiform rust in seedlings from a wild population of loblolly pine

Treesearch

Bohun B. Kinloch Jr.; Roy W. Stonecypher

1969-01-01

Striking genetic variation in susceptibility to fusiform rust was observed among SS controlled-pollinated (CP) and 48 wind-pollinated (WP) families from parent trees of loblolly pine selected at random in a natural forest stand in southwest Georgia. The mating design permitted statistical tests for estimating both additive and total genetic variance. WP families were...

Whey protein enhances normal inflammatory responses during cutaneous wound healing in diabetic rats

PubMed Central

2011-01-01

Background Prolonged wound healing is a complication of diabetes that contributes to mortality. Impaired wound healing occurs as a consequence of excessive reactive oxygen species (ROS) production. Whey protein (WP) is able to reduce the oxygen radicals and increase the levels of the antioxidant glutathione. Thus, the aim of this study was to determine whether dietary supplementation with WP could enhance normal inflammatory responses during wound healing in diabetic rats. Animals were assigned into a wounded control group (WN), a wounded diabetic group (WD) and a wounded diabetic group orally supplemented with whey protein (WDWP) at a dose of 100 mg/kg body weight. Results Whey protein was found to significantly decrease the levels of malondialdehyde (MDA), nitric oxide (NO) and ROS. A significant restoration of the glutathione level was observed in WDWP rats. During the early wound healing stage, IL-1β, TNF-α, IL-6, IL-4 and neutrophil infiltration were significantly decreased in WD mice. WP supplementation was found to restore the levels of these inflammatory markers to the levels observed in control animals. In addition, the time required for wound healing was significantly prolonged in diabetic rats. WP was found to significantly decrease the time required for wound healing in WDWP rats. Conclusion In conclusion, dietary supplementation with WP enhances the normal inflammatory responses during wound healing in diabetic mice by restoring the levels of oxidative stress and inflammatory cytokines. PMID:22168406

Efficacy of Newer Molecules, Bioagents and Botanicals against Maydis Leaf Blight and Banded Leaf and Sheath Blight of Maize

PubMed Central

Malik, Vinod Kumar; Singh, Manjeet; Hooda, Karambir Singh; Yadav, Naresh Kumar; Chauhan, Prashant Kumar

2018-01-01

Maize (Zea mays L.; 2N=20) is major staple food crop grown worldwide adapted to several biotic and abiotic stresses. Maydis leaf blight (MLB) and banded leaf and sheath blight (BLSB) are serious foliar fungal diseases may cause up to 40% and 100% grain yield loss, respectively. The present studies were undertaken to work out the efficacy of chemicals, botanicals and bioagents for the management of MLB and BLSB under field condition for two seasons Kharif 2014 and 2015. Five molecules (propiconazole 25 EC, hexaconazole 25 EC, carbendazim 50 WP, mancozeb 75 WP and carbedazim 12 WP + mancozeb 63 WP), two bioagents i.e. Trichoderma harzianum and T. viridae and three botanicals namely azadirachtin, sarpagandha and bel pathar were tested for their efficacy against MLB. Eight newer fungicides viz., difenconazole 250 SC, hexaconazole 5 EC, carbendazim 50WP, validamycin 3 L, tebuconazole 250 EC, trifloxystrobin 50 WG + tebuconazole 50 WG, azoxystrobin 250 EC and pencycuron 250 SC were evaluated against BLSB. Analysis revealed significant effects of propiconazole at 0.1%, carbendazim 12 WP + mancozeb 63 WP at 0.125% and sarpagandha leaves at 10% against MLB pathogen, whereas validamycin at 0.1% and trifloxystrobin 25 WG + tebuconazole 50 WG at 0.05% were found effective against BLSB. The slow rate of disease control virtually by the bioagents might have not shown instant effect on plant response to the yield enhancing components. The identified sources of management can be used further in strengthening the plant protection in maize against MLB and BLSB. PMID:29628818

Efficacy of Newer Molecules, Bioagents and Botanicals against Maydis Leaf Blight and Banded Leaf and Sheath Blight of Maize.

PubMed

Malik, Vinod Kumar; Singh, Manjeet; Hooda, Karambir Singh; Yadav, Naresh Kumar; Chauhan, Prashant Kumar

2018-04-01

Maize ( Zea mays L.; 2N=20) is major staple food crop grown worldwide adapted to several biotic and abiotic stresses. Maydis leaf blight (MLB) and banded leaf and sheath blight (BLSB) are serious foliar fungal diseases may cause up to 40% and 100% grain yield loss, respectively. The present studies were undertaken to work out the efficacy of chemicals, botanicals and bioagents for the management of MLB and BLSB under field condition for two seasons Kharif 2014 and 2015. Five molecules (propiconazole 25 EC, hexaconazole 25 EC, carbendazim 50 WP, mancozeb 75 WP and carbedazim 12 WP + mancozeb 63 WP), two bioagents i.e. Trichoderma harzianum and T. viridae and three botanicals namely azadirachtin, sarpagandha and bel pathar were tested for their efficacy against MLB. Eight newer fungicides viz., difenconazole 250 SC, hexaconazole 5 EC, carbendazim 50WP, validamycin 3 L, tebuconazole 250 EC, trifloxystrobin 50 WG + tebuconazole 50 WG, azoxystrobin 250 EC and pencycuron 250 SC were evaluated against BLSB. Analysis revealed significant effects of propiconazole at 0.1%, carbendazim 12 WP + mancozeb 63 WP at 0.125% and sarpagandha leaves at 10% against MLB pathogen, whereas validamycin at 0.1% and trifloxystrobin 25 WG + tebuconazole 50 WG at 0.05% were found effective against BLSB. The slow rate of disease control virtually by the bioagents might have not shown instant effect on plant response to the yield enhancing components. The identified sources of management can be used further in strengthening the plant protection in maize against MLB and BLSB.

Comparison of human immunodeficiency virus assays in window phase and elite controller samples: viral load distribution and implications for transmission risk

PubMed Central

Vermeulen, Marion; Coleman, Charl; Mitchel, Josephine; Reddy, Ravi; van Drimmelen, Harry; Fickett, Tracy; Busch, Michael; Lelie, Nico

2016-01-01

BACKGROUND After 3 years of individual-donation nucleic acid test (ID-NAT) screening by the South African National Blood Service (SANBS), a repository of 73 human immunodeficiency virus antibody (anti-HIV)-negative window period (WP)-yield samples and 28 anti-HIV–positive, HIV-RNA–negative elite controllers (ECs) became available for comparison of a p24 antigen (p24 Ag) assay (Innogenetics), two viral load assays (Siemens branch DNA [bDNA] 3.0 and Abbott real-time polymerase chain reaction [RT-PCR]), and three triplex NAT assays (Novartis Diagnostics Ultrio and Ultrio-Plus and Roche TaqScreen) by replicate testing of dilutions. STUDY DESIGN AND METHODS Viral loads were assessed by bDNA and RT-PCR assays and if below 100 copies (cps)/mL, by Ultrio limiting dilution probit analysis. The probability of virus transmission by WP and EC donations was estimated for different levels of the 50% minimum infectious dose (ID50) using Poisson distribution statistics. RESULTS The equal distribution of WP donations plotted by log HIV-RNA levels indicated a random appearance of donors in the ramp-up phase. The HIV p24 Ag assay detected 45% of WP samples and the cutoff crossing point was estimated at 8140 (bDNA)/ 22,710 (RT-PCR) cps/mL. On replicate retesting of 40 HIV p24 Ag–negative ID-NAT WP-yield samples Ultrio minipool (MP)8, Ultrio-Plus MP8, and TaqScreen MP6 detected 79, 81, and 78%, respectively. Modeling with an estimated ID50 of 31.6 virions/RBC indicated that 15% of p24 Ag–negative ID-NAT WP-yield donations would have transmitted HIV if MP6–8 NAT had been used. Only 2% of RBC transfusions from ECs are estimated to be infectious with a worst-case ID50 estimate of 316 virions. CONCLUSION Our analysis of viremia and infectivity of WP and EC donations enables comparison of the efficacy of NAT options in preventing HIV transmission risk. PMID:23445273

Comparison of human immunodeficiency virus assays in window phase and elite controller samples: viral load distribution and implications for transmission risk.

PubMed

Vermeulen, Marion; Coleman, Charl; Mitchel, Josephine; Reddy, Ravi; van Drimmelen, Harry; Fickett, Tracy; Busch, Michael; Lelie, Nico

2013-10-01

After 3 years of individual-donation nucleic acid test (ID-NAT) screening by the South African National Blood Service (SANBS), a repository of 73 human immunodeficiency virus antibody (anti-HIV)-negative window period (WP)-yield samples and 28 anti-HIV-positive, HIV-RNA-negative elite controllers (ECs) became available for comparison of a p24 antigen (p24 Ag) assay (Innogenetics), two viral load assays (Siemens branch DNA [bDNA] 3.0 and Abbott real-time polymerase chain reaction [RT-PCR]), and three triplex NAT assays (Novartis Diagnostics Ultrio and Ultrio-Plus and Roche TaqScreen) by replicate testing of dilutions. Viral loads were assessed by bDNA and RT-PCR assays and if below 100 copies (cps)/mL, by Ultrio limiting dilution probit analysis. The probability of virus transmission by WP and EC donations was estimated for different levels of the 50% minimum infectious dose (ID50 ) using Poisson distribution statistics. The equal distribution of WP donations plotted by log HIV-RNA levels indicated a random appearance of donors in the ramp-up phase. The HIV p24 Ag assay detected 45% of WP samples and the cutoff crossing point was estimated at 8140 (bDNA)/22,710 (RT-PCR) cps/mL. On replicate retesting of 40 HIV p24 Ag-negative ID-NAT WP-yield samples Ultrio minipool (MP)8, Ultrio-Plus MP8, and TaqScreen MP6 detected 79, 81, and 78%, respectively. Modeling with an estimated ID50 of 31.6 virions/RBC indicated that 15% of p24 Ag-negative ID-NAT WP-yield donations would have transmitted HIV if MP6-8 NAT had been used. Only 2% of RBC transfusions from ECs are estimated to be infectious with a worst-case ID50 estimate of 316 virions. Our analysis of viremia and infectivity of WP and EC donations enables comparison of the efficacy of NAT options in preventing HIV transmission risk. © 2013 American Association of Blood Banks.

Predicting First Graders' Development of Calculation versus Word-Problem Performance: The Role of Dynamic Assessment.

PubMed

Seethaler, Pamela M; Fuchs, Lynn S; Fuchs, Douglas; Compton, Donald L

2012-02-01

The purpose of this study was to assess the value of dynamic assessment (DA; degree of scaffolding required to learn unfamiliar mathematics content) for predicting 1(st)-grade calculations (CA) and word problems (WP) development, while controlling for the role of traditional assessments. Among 184 1(st) graders, predictors (DA, Quantity Discrimination, Test of Mathematics Ability, language, and reasoning) were assessed near the start of 1(st) grade. CA and WP were assessed near the end of 1(st) grade. Planned regression and commonality analyses indicated that for forecasting CA development, Quantity Discrimination, which accounted for 8.84% of explained variance, was the single most powerful predictor, followed by Test of Mathematics Ability and DA; language and reasoning were not uniquely predictive. By contrast, for predicting WP development, DA was the single most powerful predictor, which accounted for 12.01% of explained variance, with Test of Mathematics Ability, Quantity Discrimination, and language also uniquely predictive. Results suggest that different constellations of cognitive resources are required for CA versus WP development and that DA may be useful in predicting 1(st)-grade mathematics development, especially WP.

Predicting First Graders’ Development of Calculation versus Word-Problem Performance: The Role of Dynamic Assessment

PubMed Central

Seethaler, Pamela M.; Fuchs, Lynn S.; Fuchs, Douglas; Compton, Donald L.

2012-01-01

The purpose of this study was to assess the value of dynamic assessment (DA; degree of scaffolding required to learn unfamiliar mathematics content) for predicting 1st-grade calculations (CA) and word problems (WP) development, while controlling for the role of traditional assessments. Among 184 1st graders, predictors (DA, Quantity Discrimination, Test of Mathematics Ability, language, and reasoning) were assessed near the start of 1st grade. CA and WP were assessed near the end of 1st grade. Planned regression and commonality analyses indicated that for forecasting CA development, Quantity Discrimination, which accounted for 8.84% of explained variance, was the single most powerful predictor, followed by Test of Mathematics Ability and DA; language and reasoning were not uniquely predictive. By contrast, for predicting WP development, DA was the single most powerful predictor, which accounted for 12.01% of explained variance, with Test of Mathematics Ability, Quantity Discrimination, and language also uniquely predictive. Results suggest that different constellations of cognitive resources are required for CA versus WP development and that DA may be useful in predicting 1st-grade mathematics development, especially WP. PMID:22347725

Experimental Comparison of Efficiency of First Aid Dressings in Burning White Phosphorus on Bacon Model.

PubMed

Witkowski, Wojciech; Surowiecka-Pastewka, Agnieszka; Biesaga, Magdalena; Gierczak, Tomasz

2015-08-12

The aim of this study was to determine effectiveness of first aid dressings in extinguishing burning white phosphorous (WP), eliminating WP pieces from the surface, inhibiting re-ignition on the model (fresh bacon covered with military uniform), and preventing from late re-ignition caused by persistent WP pieces. Burning WP was extinguished with several dressings: tactical Military Dressing (WJ10), wet gauze, 2 hydrocolloids, and 3 prototypes of hydrocolloids developed by the authors. All examined dressings were effective in extinguishing WP provided that the entire area of the burning substance was completely covered. Moist gauze was especially effective in extinguishing WP, and also removed and absorbed the majority of the WP mass, preventing deeper penetration of WP particles. The immediate re-ignition was observed when all the remaining examined dressings were removed from the bacon. A stream of water was dangerous, as it splashed and transferred pieces of WP around. Moist gauze placed on burning WP for approximately 3 min was most effective in extinguishing WP and removing most of the WP pieces. We recommend moist gauze, used once or twice, as the best primary means for WP elimination and preventing tissue penetration. As a dressing used for medical evacuation (MEDEVAC), or as a second step after complete removal of visible WP, innovative hydrocolloid or hydrogel dressings should be used.

Experimental Comparison of Efficiency of First Aid Dressings in Burning White Phosphorus on Bacon Model

PubMed Central

Witkowski, Wojciech; Surowiecka-Pastewka, Agnieszka; Biesaga, Magdalena; Gierczak, Tomasz

2015-01-01

Background The aim of this study was to determine effectiveness of first aid dressings in extinguishing burning white phosphorous (WP), eliminating WP pieces from the surface, inhibiting re-ignition on the model (fresh bacon covered with military uniform), and preventing from late re-ignition caused by persistent WP pieces. Material/Methods Burning WP was extinguished with several dressings: tactical Military Dressing (WJ10), wet gauze, 2 hydrocolloids, and 3 prototypes of hydrocolloids developed by the authors. Results All examined dressings were effective in extinguishing WP provided that the entire area of the burning substance was completely covered. Moist gauze was especially effective in extinguishing WP, and also removed and absorbed the majority of the WP mass, preventing deeper penetration of WP particles. The immediate re-ignition was observed when all the remaining examined dressings were removed from the bacon. A stream of water was dangerous, as it splashed and transferred pieces of WP around. Conclusions Moist gauze placed on burning WP for approximately 3 min was most effective in extinguishing WP and removing most of the WP pieces. We recommend moist gauze, used once or twice, as the best primary means for WP elimination and preventing tissue penetration. As a dressing used for medical evacuation (MEDEVAC), or as a second step after complete removal of visible WP, innovative hydrocolloid or hydrogel dressings should be used. PMID:26264209

Antioxidant properties of selected Oriental non-culinary/nutraceutical herb extracts as evaluated in raw and cooked meat.

PubMed

Han, J; Rhee, K S

2005-05-01

Ethanol extracts of white peony (WP), red peony (RP), sappanwood (SW), Moutan peony (MP), rehmania (RE) or angelica (AN) were individually added to ground goat meat at 0.5-2.0% (g dry extract/100 g final meat sample), and raw and cooked samples were aerobically refrigerated for 0, 3 or 6 days. These extracts and rosemary extract (RO) were also individually added to salted or unsalted ground beef at 0.01-0.25% and refrigerated as raw or cooked patties. WP, RP, RE, SW and MP markedly reduced (P<0.05) lipid oxidation in cooked-stored goat meat. With 0.25% of WP, RP, SW, MP or RO in beef, lipid oxidation during storage was minimal in raw and cooked patties (plain or salted); raw patty redness values at day 6 were higher (P<0.05) for SW, WP, RP or MP than RO treatment or the control. At 0.01%, SW was more antioxidative (P<0.05) than the other extracts.

Contributions of the German Research Center for Geosciences (GFZ) to the EPOS Implementation Phase 2015-18 (European Plate Observing System)

NASA Astrophysics Data System (ADS)

Hoffmann, T. L.; Lauterjung, J.

2016-12-01

The European Plate Observing System project is currently approaching the end of year one of its four-year Implementation Phase 2015-18 (EPOS-IP). Established under the Horizon 2020 Programme INFRADEV-3, the EPOS cyberinfrastructure is being established as an ERIC (European Research Infrastructure Consortium) and encompasses the implementation of both the EPOS Integrated Core Services (ICS) for solid Earth Science and a multitude of EPOS Thematic Core Services (TCS). The TCS-Elements themselves will integrate a number of Service Providers that deliver Data, Data Products, Services and Software (DDSS) to their specific scientific community. As one of the 29 awardees of the EC grant, the German Research Center for Geosciences (GFZ) plays an important role in the implementation of EPOS and its Thematic and Integrated Core Services. The presented poster will give an overview of GFZ's participation in nine technical EPOS Work Packages (WP7 ICS Development, WP8 Seismology, WP11 Volcano Observations, WP12 Satellite Data, WP13 Geomagnetic Observations, WP14 Anthropogenic Hazards, WP15 Geological Information and Modelling, WP16 Multi-Scale Laboratories and WP17 Geo Energy Test Beds) as well as in four administrative EPOS Work Packages (WP2 Communication, WP3 Harmonization, WP4 Legal & Governance, and WP5 Financial).

Temperature niche shift observed in a Lepidoptera population under allochronic divergence.

PubMed

Santos, H; Paiva, M R; Tavares, C; Kerdelhué, C; Branco, M

2011-09-01

A process of adaptive divergence for tolerance to high temperatures was identified using a rare model system, consisting of two sympatric populations of a Lepidoptera (Thaumetopoea pityocampa) with different life cycle timings, a 'mutant' population with summer larval development, Leiria SP, and the founder natural population, having winter larval development, Leiria WP. A third, allopatric population (Bordeaux WP) was also studied. First and second instar larvae were experimentally exposed to daily-cycles of heat treatment reaching maximum values of 36, 38, 40 and 42 °C; control groups placed at 25 °C. A lethal temperature effect was only significant at 42 °C, for Leiria SP, whereas all temperatures tested had a significant negative effect upon Leiria WP, thus indicating an upper threshold of survival c.a. 6 °C above that of the WP. Cox regression model, for pooled heat treatments, predicted mortality hazard to increase for Leiria WP (+108%) and Bordeaux WP (+78%) in contrast to Leiria SP; to increase by 24% for each additional °C; and to decrease by 53% from first to second instar larvae. High variability among individuals was observed, a population characteristic that may favour selection and consequent adaptation. Present findings provide an example of ecological differentiation, following a process of allochronic divergence. Results further contribute to a better understanding of the implications of climate change for ecological genetics. © 2011 The Authors. Journal of Evolutionary Biology © 2011 European Society For Evolutionary Biology.

Electrical power system WP-04

NASA Astrophysics Data System (ADS)

Nored, Donald L.

Viewgraphs on Space Station Freedom Electrical Power System (EPS) WP-40 are presented. Topics covered include: key EPS technical requirements; photovoltaic power module systems; solar array assembly; blanket containment box and box positioning subassemblies; solar cell; bypass diode assembly; Kapton with atomic oxygen resistant coating; sequential shunt unit; gimbal assembly; energy storage subsystem; thermal control subsystem; direct current switching unit; integrated equipment assembly; PV cargo element; PMAD system; and PMC and AC architecture.

Electrical power system WP-04

NASA Technical Reports Server (NTRS)

Nored, Donald L.

1990-01-01

Viewgraphs on Space Station Freedom Electrical Power System (EPS) WP-40 are presented. Topics covered include: key EPS technical requirements; photovoltaic power module systems; solar array assembly; blanket containment box and box positioning subassemblies; solar cell; bypass diode assembly; Kapton with atomic oxygen resistant coating; sequential shunt unit; gimbal assembly; energy storage subsystem; thermal control subsystem; direct current switching unit; integrated equipment assembly; PV cargo element; PMAD system; and PMC and AC architecture.

A TNF receptor loop peptide mimic blocks RANK ligand–induced signaling, bone resorption, and bone loss

PubMed Central

Aoki, Kazuhiro; Saito, Hiroaki; Itzstein, Cecile; Ishiguro, Masaji; Shibata, Tatsuya; Blanque, Roland; Mian, Anower Hussain; Takahashi, Mariko; Suzuki, Yoshifumi; Yoshimatsu, Masako; Yamaguchi, Akira; Deprez, Pierre; Mollat, Patrick; Murali, Ramachandran; Ohya, Keiichi; Horne, William C.; Baron, Roland

2006-01-01

Activating receptor activator of NF-κB (RANK) and TNF receptor (TNFR) promote osteoclast differentiation. A critical ligand contact site on the TNFR is partly conserved in RANK. Surface plasmon resonance studies showed that a peptide (WP9QY) that mimics this TNFR contact site and inhibits TNF-α–induced activity bound to RANK ligand (RANKL). Changing a single residue predicted to play an important role in the interaction reduced the binding significantly. WP9QY, but not the altered control peptide, inhibited the RANKL-induced activation of RANK-dependent signaling in RAW 264.7 cells but had no effect on M-CSF–induced activation of some of the same signaling events. WP9QY but not the control peptide also prevented RANKL-induced bone resorption and osteoclastogenesis, even when TNFRs were absent or blocked. In vivo, where both RANKL and TNF-α promote osteoclastogenesis, osteoclast activity, and bone loss, WP9QY prevented the increased osteoclastogenesis and bone loss induced in mice by ovariectomy or low dietary calcium, in the latter case in both wild-type and TNFR double-knockout mice. These results suggest that a peptide that mimics a TNFR ligand contact site blocks bone resorption by interfering with recruitment and activation of osteoclasts by both RANKL and TNF. PMID:16680194

Fault-controlled pluton emplacement in the Sevier fold-and-thrust belt of southwest Montana, USA

NASA Astrophysics Data System (ADS)

Kalakay, Thomas J.; John, Barbara E.; Lageson, David R.

2001-06-01

Problems associated with syncompressional pluton emplacement center on the need to make room for magma in environments where crustal shortening, not extension, occurs on a regional scale. New structural data from the Pioneer and Boulder batholiths of southwest Montana, USA, suggest emplacement at the top of frontal thrust ramps as composite tabular bodies at crustal depths between 1 and 10 km. Frontal thrust facilitated pluton emplacement was accommodated by: (1) a magma feeder zone created along the ramp interface; (2) providing 'releasing steps' at ramp tops that serve as initial points of emplacement and subsequent pluton growth; and (3) localizing antithetic back-thrusts that assist in pluton ascent. A model of magma emplacement is proposed that involves these elements. This model for syntectonic ramp-top emplacement of plutons helps explain how space is made for plutons within fold-and-thrust belts.

Effectiveness of Diflubenzuron in the control of houseflies.

PubMed

Tilak, Rina; Verma, A K; Wankhade, Urmila B

2010-06-01

Houseflies are one of the major pest problems worldwide. The current housefly control strategy in the country hinges on the use of Dichlorvos as a housefly larvicide and pyrethrum spray in kitchens/dining areas. The present study was undertaken to evaluate the newer housefly control options in the wake of concerns about human toxicity of Dichlorvos and its continued use in public health. Efficacy of Diflubenzuron WP and granule formulations (chitin synthesis inhibitor) vis-à-vis Dichlorvos EC in the control of housefly was assessed in laboratory by adult emergence inhibition after treatment and in field conditions by estimation of density post-application up to three weeks using standard methods. Dichlorvos EC and Diflubenzuron formulations (WP and granule) brought about 100% inhibition of adult emergence under laboratory conditions. However, in the field evaluation, effective suppression of housefly population was brought about by Dichlorvos and Diflubenzuron granule formulation (though delayed). Dichlorvos EC and Diflubenzuron granule formulation are effective housefly larvicides. It is recommended that Diflubenzuron WP formulation be evaluated at a higher frequency to enhance its effectiveness and its use may be considered in conjunction with an initial suppression of housefly adults with an adulticide, e.g. Cyphenothrin, etc.

The Prevalence, Attitudes, and Correlates of Waterpipe Smoking Among High School Students in Iran: a Cross-Sectional Study.

PubMed

Ziaei, Reza; Mohammadi, Reza; Dastgiri, Saeed; Viitasara, Eija; Rahimi, Vahab Asl; Jeddi, Abolfazl; Soares, Joaquim

2016-12-01

The purpose of the present study was to determine the correlates of waterpipe (WP) smoking among 15-17-year-old high school students in Iran. Data were collected using the Global Youth Tobacco Survey (GYTS), a self-administrated questionnaire distributed to a representative sample of high school students aged 15-17 in the city of Tabriz. Current WP smoking was defined as past 30-day use, and ever WP smoking was defined as at least one or two lifetime puffs. Differences in WP use, knowledge, and attitudes were analyzed using chi-square and Fisher exact tests. Binary logistic regression estimated the association between relevant independent variables (e.g., age) and the dependent variables (current/ever WP smoking). Of 1517 students, 21.6 % (95 % confidence interval [CI] = 19.5, 23.8) were ever WP smokers, and 9.7 % (95 % CI = 8.2, 11.2) were current WP smokers. Of current WP smokers, 40.3 % have stated that they want to stop smoking now. Moreover, 14.1 % of non-WP smokers reported that they might enjoy smoking WP. Of current WP smokers, 49.0 % have smoked at cafés. Additionally, 95.3 % of current WP smokers reported that their age did not prevent them from being served a WP. Studying in high school third grade (adjusted odds ratios (AORs) = 1.70; 95 % CI [1.10, 2.63]), experience of cigarette smoking (AORs = 1.57; 95 % CI [1.12, 2.20]), and being prepared to accept a WP offered by close friends (AORs = 3.31; 95 % CI [2.17, 5.04]) were independently associated with ever WP smoking, and accepting a WP offered by close friends (AORs = 4.36; 95 % CI [2.69, 7.07]) and gender (female) (AORs = 0.45; 95 % CI [0.30, 0.70] were independently associated with current WP smoking. Prevalence of current and ever WP smoking is high in Tabriz. There is an urgent need to design interventions in order to increase students' and their parents' awareness regarding the harmfulness of WP, and to establish legal measures to restrict adolescents' access to WPs and tobacco in society.

Improving low fat meatball characteristics by adding whey powder.

PubMed

Serdaroğlu, Meltem

2006-01-01

In this study whey powder (WP) at levels of 0%, 2% and 4% was added to beef meatballs formulated with 5%, 10% and 20% fat levels. Raw and cooked meatballs were analyzed for protein, fat, moisture, ash and pH. Meatballs were evaluated for cooking characteristics, juiciness, colour parameters (L*,a*,b*) and sensory properties. Addition of WP did not affect fat and protein contents of meatballs. Addition of 2% or 4% WP significantly increased cooking yield regardless of the fat level. Both fat level and WP level significantly affected fat retention values of meatballs. Incorporating WP had no effect on meatball juiciness. Addition of WP increased fat and moisture retention of meatballs. Twenty percent fat resulted in higher L* and lower a* values. Adding WP resulted in higher L* values but WP had no effect on a* and b* values. WP had no detrimental effect on sensory properties.

Enhanced biocompatibility and osteogenic potential of mesoporous magnesium silicate/polycaprolactone/wheat protein composite scaffolds.

PubMed

Kang, Yun Gyeong; Wei, Jie; Shin, Ji Won; Wu, Yan Ru; Su, Jiacan; Park, Young Shik; Shin, Jung-Woog

2018-01-01

Successful bone tissue engineering using scaffolds is primarily dependent on the properties of the scaffold, including biocompatibility, highly interconnected porosity, and mechanical integrity. In this study, we propose new composite scaffolds consisting of mesoporous magnesium silicate (m_MS), polycaprolactone (PCL), and wheat protein (WP) manufactured by a rapid prototyping technique to provide a micro/macro porous structure. Experimental groups were set based on the component ratio: (1) WP0% (m_MS:PCL:WP =30:70:0 weight per weight; w/w); (2) WP15% (m_MS:PCL:WP =30:55:15 w/w); (3) WP30% (m_MS:PCL:WP =30:40:30 w/w). Evaluation of the properties of fabricated scaffolds indicated that increasing the amount of WP improved the surface hydrophilicity and biodegradability of m_MS/PCL/WP composites, while reducing the mechanical strength. Moreover, experiments were performed to confirm the biocompatibility and osteogenic differentiation of human mesenchymal stem cells (MSCs) according to the component ratio of the scaffold. The results confirmed that the content of WP affects proliferation and osteogenic differentiation of MSCs. Based on the last day of the experiment, ie, the 14th day, the proliferation based on the amount of DNA was the best in the WP30% group, but all of the markers measured by PCR were the most expressed in the WP15% group. These results suggest that the m_MS/PCL/WP composite is a promising candidate for use as a scaffold in cell-based bone regeneration.

Antidepressant-like effects of ecstasy in subjects with a predisposition to depression.

PubMed

Majumder, Irina; White, Jason M; Irvine, Rodney J

2012-10-01

Positive effects of ecstasy on mood and self-esteem due to increased synaptic serotonin levels may indicate a potential antidepressant-like action. This effect may be more prominent in subjects with a pre-existing mood disturbance who may use ecstasy more frequently as a 'self-medication'. This study compared depressive symptoms and the immediate effects of ecstasy on mood in subjects with (WP) and without (NP) a predisposition to depression. Current ecstasy users were assessed using the profile of mood states (POMS) and beck depression inventory (BDI) when drug-free, and during social gathering, when 20 subjects voluntarily consumed ecstasy (ecstasy group) and 20 abstained from ecstasy (control group). Predisposition to depression was determined using the Brief Symptom Inventory. During social gathering, POMS and BDI were administered 60 min after ecstasy consumption, or at matched time for controls. 3,4-Methylenedioxymethamphetamine (MDMA) exposure was confirmed using saliva samples collected 60 min after pill ingestion. There was no difference in ecstasy use patterns between the groups. When drug-free, the WP subjects had greater mood disturbance and depressive symptoms than the NP group (POMS: NP 5.85±1.63, WP 14.5±2.81, p<0.05, BDI: NP 4.9±0.86, WP 11.2±1.65, p<0.01). During social gathering, WP subjects who consumed ecstasy reported a significant decrease in depressive symptoms (F(1,35)=5.47, p<0.05). A decrease in depressive symptoms was observed in subjects predisposed to depression. This antidepressant-like action of MDMA may contribute to its use, particularly among people with an existing or latent depressive disorder. Copyright © 2012 Elsevier Ltd. All rights reserved.

Low-volume application by mist-blower compared with conventional compression sprayer treatment of houses with residual pyrethroid to control the malaria vector Anopheles albimanus in Mexico.

PubMed

Villarreal, C; Rodriguez, M H; Bown, D N; Arredondo-Jiménez, J I

1995-04-01

Village-scale trials were carried out in southern Mexico to compare the efficacy of indoor-spraying of the pyrethroid insecticide lambda-cyhalothrin applied either as low-volume (LV) aqueous emulsion or as wettable-powder (WP) aqueous suspension for residual control of the principal coastal malaria vector Anopheles albimanus. Three indoor spray rounds were conducted at 3-month intervals using back-pack mist-blowers to apply lambda-cyhalothrin 12.5 mg a.i./m2 by LV, whereas the WP was applied by conventional compression sprayer at a mean rate of 26.5 mg a.i./m2. Both treatments caused mosquito mortality indoors and outdoors (collected inside house curtains) as a result of contact with treated surfaces before and after feeding, but had no significant impact on overall population density of An. albimanus resting indoors or assessed by human bait collections. Contact bioassays showed that WP and LV treatments with lambda-cyhalothrin were effective for 12-20 weeks (> 75% mortality) without causing excito-repellency. Compared to the WP treatment (8 houses/man/day), LV treatment (25 houses/man/day) was more than 3 times quicker per house, potentially saving 68% of labour costs. This is offset, however, by the much lower unit price of a compression sprayer (e.g. Hudson 'X-pert' at US$120) than a mist-blower (e.g. 'Super Jolly' at US$350), and higher running costs for LV applications. It was calculated, therefore, that LV becomes more economical than WP after 18.8 treatments/100 houses/10 men at equivalent rates of application, or after 7.6 spray rounds with half-rate LV applications.

Protocol for Pertussis Immunisation and Food Allergy (PIFA): a case–control study of the association between pertussis vaccination in infancy and the risk of IgE-mediated food allergy among Australian children

PubMed Central

Marsh, Julie A; Campbell, Dianne E; Gold, Michael S; Allen, Katrina J; Richmond, Peter; Waddington, Claire S; Snelling, Thomas L

2018-01-01

Introduction Atopic diseases, including food allergy, have become a predominant cause of chronic illness among children in developed countries. In Australia, a rise in hospitalisations among infants coded as anaphylaxis to foods coincided with the replacement of whole-cell pertussis (wP) vaccine with subunit acellular pertussis (aP) vaccine on the national immunisation schedule in the late 1990s. Atopy is characterised by a tendency to mount T helper type 2 (Th2) responses to otherwise innocuous environmental antigens. Compared with infants who receive aP as their first pertussis vaccine, those who receive wP appear less likely to mount Th2 immune responses to either vaccine or extraneous antigens. We therefore speculate that removal of wP from the vaccine schedule contributed to the observed rise in IgE-mediated food allergy among Australian infants. Methods and analysis This is a retrospective individually matched case–control study among a cohort of Australian children born from 1997 to 1999, the period of transition from wP to aP vaccines; we include in the cohort children listed on Australia’s comprehensive population-based immunisation register as having received a first dose of either pertussis vaccine by 16 weeks old. 500 cohort children diagnosed as having IgE-mediated food allergy at specialist allergy clinics will be included as cases. Controls matched to each case by date and jurisdiction of birth and regional socioeconomic index will be sampled from the immunisation register. Conditional logistic regression will be used to estimate OR (±95% CI) of receipt of wP (vs aP) as the first vaccine dose among cases compared with controls. Ethics and dissemination The study is approved by all relevant human research ethics committees: Western Australia Child and Adolescent Health Services (2015052EP), Women’s and Children’s Hospital (HREC/15/WCHN/162), Royal Children’s Hospital (35230A) and Sydney Children’s Hospital Network (HREC/15/SCHN/405). Outcomes will be disseminated through publication and scientific presentation. Trial registration number NCT02490007. PMID:29391374

Harm perception, attitudes and predictors of waterpipe (shisha) smoking among secondary school adolescents in Al-Hassa, Saudi Arabia.

PubMed

Amin, Tarek Tawfik; Amr, Mostafa Abdel Monem; Zaza, Burhan Omar; Suleman, Wassem

2010-01-01

This study aimed to determine the prevalence and social determinants of waterpipe (WP) smoking among secondary school students in Al-Hassa, Saudi Arabia and to assess their health related knowledge and attitudes toward WP. A cross-sectional study was conducted with 1,652 Saudi secondary school students of both genders aged between 15-19 years selected by multistage sampling method. A self-administered anonymous Arabic version of Global Youth Tobacco Survey modified with items dedicated to WP smoking and to assess perception of health related hazards and attitudes towards WP was employed for data collection. Prevalence of current smokers 'all forms' was 30.3% among males (C.I= 27.5- 33.2%) and 8.5% in females (C.I= 6.6-10.9%). WP was used by 53.9% of the current tobacco users, significantly higher among older age students. Of the regular WP smokers, 20.7% smoked WP on daily basis, 23.8% weekly, 64.2% stated using flavored " Muassel " tobacco. Primary motives for WP smoking were outings with friends, company, boredom and wasting time. Of the total, 49.7% of students stated that WP smoking is less harmful than cigarettes, 60.5% believed that harmful substances were purified through water filtration, with non-addictive properties in 67.8%. Knowledge about health hazards of WP smoking was low, irrespective of student's smoking status. WP smoking is more socially acceptable than cigarettes (52.1%), represents a good opportunity for gathering of friends and family (33.8%), and smoking of WP can relieve stress and tensions (37.8%). Hierarchical regression analysis showed that socializing motives, cigarette smoking, smoking among close family and friends, male gender and increasing age were positive predictors for WP smoking. Social acceptability, poor knowledge of WP health related hazards and certain socio demographics are favoring the increasing current trend of WP use among adolescents in Al Hassa, Saudi Arabia.

Cardiac Vagal Tone and Quality of Parenting Show Concurrent and Time-Ordered Associations That Diverge in Abusive, Neglectful, and Non-Maltreating Mothers

PubMed Central

Skowron, Elizabeth A.; Cipriano-Essel, Elizabeth; Benjamin, Lorna Smith; Pincus, Aaron L.; Van Ryzin, Mark J.

2014-01-01

Concurrent and lagged maternal respiratory sinus arrhythmia (RSA) was monitored in the context of parenting. One hundred and forty-one preschooler-mother dyads—involved with child welfare as documented perpetrators of child abuse or neglect, or non-maltreating (non-CM)—were observed completing a resting baseline and joint challenge task. Parenting behaviors were coded using SASB (Benjamin, 1996) and maternal RSA was simultaneously monitored, longitudinally-nested within-person (WP), and subjected to MLM. Abusive and neglectful mothers displayed less positive parenting and more strict/hostile control, relative to non-CM mothers. Non-CM mothers displayed greater WP heterogeneity in variance over time in their RSA scores, and greater consistency over time in their parenting behaviors, relative to abusive or neglectful mothers. CM group also moderated concurrent and lagged WP associations in RSA and positive parenting. When abusive mothers displayed lower RSA in a given epoch, relative to their task average, they showed concurrent increases in positive parenting, and higher subsequent levels of hostile control in the following epoch, suggesting that it is physiologically taxing for abusive mothers to parent in positive ways. In contrast, lagged effects for non-CM mothers were observed in which RSA decreases led to subsequent WP increases in positive parenting and decreases in control. Reversed models were significant only for neglectful mothers: Increases in positive parenting led to subsequent increases in RSA levels, and increases in strict, hostile control led to subsequent RSA decreases. These results provide new evidence that concurrent and time-ordered coupling in maternal physiology and behavior during parenting vary in theoretically meaningful ways across CM and non-CM mothers. Implications for intervention and study limitations are discussed. PMID:24729945

Contributions of the German Research Center for Geosciences (GFZ) to the EPOS (European Plate Observing System) Implementation Phase 2015-18

NASA Astrophysics Data System (ADS)

Hoffmann, T. L.; Lauterjung, J.

2017-12-01

The European Plate Observing System project is currently approaching the end of year two of its four-year Implementation Phase 2015-18 (EPOS-IP). Under the Horizon 2020 Programme INFRADEV-3, the EPOS cyberinfrastructure is being established as an ERIC (European Research Infrastructure Consortium) and encompasses the implementation of both the EPOS Integrated Core Services (ICS) for solid Earth Science and a multitude of EPOS Thematic Core Services (TCS). During year two, a basic set of ICS and TCS services was developed and implemented, so that in October 2017 the validation phase (year 3) of EPOS is ready to be launched. Up to now, various TCS-Elements have integrated different Service Providers (SD) that are delivering Data, Data Products, Services and Software (DDSS) to their specific scientific community. As one of the 29 awardees of the EC grant, the German Research Center for Geosciences (GFZ) plays an important role in the implementation of EPOS and its Thematic and Integrated Core Services. The presented poster will give an overview of GFZ's participation in the work of nine technical EPOS Work Packages (WP7 ICS Development, WP8 Seismology, WP11 Volcano Observations, WP12 Satellite Data, WP13 Geomagnetic Observations, WP14 Anthropogenic Hazards, WP15 Geological Information and Modelling, WP16 Multi-Scale Laboratories and WP17 Geo Energy Test Beds) as well as in four administrative EPOS Work Packages (WP2 Communication, WP3 Harmonization, WP4 Legal & Governance, and WP5 Financial).

Enhanced biocompatibility and osteogenic potential of mesoporous magnesium silicate/polycaprolactone/wheat protein composite scaffolds

PubMed Central

Kang, Yun Gyeong; Wei, Jie; Shin, Ji Won; Wu, Yan Ru; Su, Jiacan; Park, Young Shik; Shin, Jung-Woog

2018-01-01

Background Successful bone tissue engineering using scaffolds is primarily dependent on the properties of the scaffold, including biocompatibility, highly interconnected porosity, and mechanical integrity. Methods In this study, we propose new composite scaffolds consisting of mesoporous magnesium silicate (m_MS), polycaprolactone (PCL), and wheat protein (WP) manufactured by a rapid prototyping technique to provide a micro/macro porous structure. Experimental groups were set based on the component ratio: (1) WP0% (m_MS:PCL:WP =30:70:0 weight per weight; w/w); (2) WP15% (m_MS:PCL:WP =30:55:15 w/w); (3) WP30% (m_MS:PCL:WP =30:40:30 w/w). Results Evaluation of the properties of fabricated scaffolds indicated that increasing the amount of WP improved the surface hydrophilicity and biodegradability of m_MS/PCL/WP composites, while reducing the mechanical strength. Moreover, experiments were performed to confirm the biocompatibility and osteogenic differentiation of human mesenchymal stem cells (MSCs) according to the component ratio of the scaffold. The results confirmed that the content of WP affects proliferation and osteogenic differentiation of MSCs. Based on the last day of the experiment, ie, the 14th day, the proliferation based on the amount of DNA was the best in the WP30% group, but all of the markers measured by PCR were the most expressed in the WP15% group. Conclusion These results suggest that the m_MS/PCL/WP composite is a promising candidate for use as a scaffold in cell-based bone regeneration. PMID:29520139

Resistant starch and protein intake enhances fat oxidation and feelings of fullness in lean and overweight/obese women.

PubMed

Gentile, Christopher L; Ward, Emery; Holst, Jens Juul; Astrup, Arne; Ormsbee, Michael J; Connelly, Scott; Arciero, Paul J

2015-10-29

Diets high in either resistant starch or protein have been shown to aid in weight management. We examined the effects of meals high in non-resistant or resistant starch with and without elevated protein intake on substrate utilization, energy expenditure, and satiety in lean and overweight/obese women. Women of varying levels of adiposity consumed one of four pancake test meals in a single-blind, randomized crossover design: 1) waxy maize (control) starch (WMS); 2) waxy maize starch and whey protein (WMS+WP); 3) resistant starch (RS); or 4) RS and whey protein (RS+WP). Total post-prandial energy expenditure did not differ following any of the four test meals (WMS = 197.9 ± 8.9; WMS+WP = 188 ± 8.1; RS = 191.9 ± 8.9; RS+WP = 195.8 ± 8.7, kcals/180 min), although the combination of RS+WP, but not either intervention alone, significantly increased (P <0.01) fat oxidation (WMS = 89.5 ± 5.4; WMS+WP = 84.5 ± 7.2; RS = 97.4 ± 5.4; RS+WP = 107.8 ± 5.4, kcals/180 min). Measures of fullness increased (125% vs. 45%) and hunger decreased (55% vs. 16%) following WP supplemented versus non-whey conditions (WMS+WP, RS+WP vs. WMS, RS), whereas circulating hunger and satiety factors were not different among any of the test meals. However, peptide YY (PYY) was significantly elevated at 180 min following RS+WP meal. The combined consumption of dietary resistant starch and protein increases fat oxidation, PYY, and enhances feelings of satiety and fullness to levels that may be clinically relevant if maintained under chronic conditions. This trial was registered at clinicaltrials.gov as NCT02418429.

DESIGN ANALYSIS FOR THE NAVAL SNF WASTE PACKAGE

DOE Office of Scientific and Technical Information (OSTI.GOV)

T.L. Mitchell

2000-05-31

The purpose of this analysis is to demonstrate the design of the naval spent nuclear fuel (SNF) waste package (WP) using the Waste Package Department's (WPD) design methodologies and processes described in the ''Waste Package Design Methodology Report'' (CRWMS M&O [Civilian Radioactive Waste Management System Management and Operating Contractor] 2000b). The calculations that support the design of the naval SNF WP will be discussed; however, only a sub-set of such analyses will be presented and shall be limited to those identified in the ''Waste Package Design Sensitivity Report'' (CRWMS M&O 2000c). The objective of this analysis is to describe themore » naval SNF WP design method and to show that the design of the naval SNF WP complies with the ''Naval Spent Nuclear Fuel Disposal Container System Description Document'' (CRWMS M&O 1999a) and Interface Control Document (ICD) criteria for Site Recommendation. Additional criteria for the design of the naval SNF WP have been outlined in Section 6.2 of the ''Waste Package Design Sensitivity Report'' (CRWMS M&O 2000c). The scope of this analysis is restricted to the design of the naval long WP containing one naval long SNF canister. This WP is representative of the WPs that will contain both naval short SNF and naval long SNF canisters. The following items are included in the scope of this analysis: (1) Providing a general description of the applicable design criteria; (2) Describing the design methodology to be used; (3) Presenting the design of the naval SNF waste package; and (4) Showing compliance with all applicable design criteria. The intended use of this analysis is to support Site Recommendation reports and assist in the development of WPD drawings. Activities described in this analysis were conducted in accordance with the technical product development plan (TPDP) ''Design Analysis for the Naval SNF Waste Package (CRWMS M&O 2000a).« less

Phase II randomized clinical trial evaluating neoadjuvant chemotherapy regimens with weekly paclitaxel or eribulin followed by doxorubicin and cyclophosphamide in women with locally advanced HER2-negative breast cancer: NSABP Foundation Study FB-9.

PubMed

Abraham, Jame; Robidoux, André; Tan, Antoinette R; Limentani, Steven; Sturtz, Keren; Shalaby, Ibrahim; Alcorn, Hope; Buyse, Marc E; Wolmark, Norman; Jacobs, Samuel A

2015-07-01

Locally advanced breast cancer (LABC) is a good setting in which to monitor response to neoadjuvant chemotherapy, to downsize the tumor (which facilitates breast-conserving surgery), and to test newer agents in untreated patients. Eribulin (E) has shown activity in patients who have undergone previous taxane, anthracycline, and capecitabine treatment. We aimed to evaluate the neoadjuvant use of E followed by doxorubicin and cyclophosphamide (AC) in patients with HER2-negative LABC, using as a control a randomized group of women who received weekly paclitaxel (WP). Fifty women with LABC were accrued January-August 2013. Patients were randomized (1:2) to receive either WP (N = 19) for 12 treatments or E (N = 31) every 3 weeks for 4 cycles followed by AC every 3 weeks for 4 cycles before surgery. 17/19 patients who took WP and 25/30 who took E completed all cycles. Patients were evaluated by clinical examination and breast MRI at baseline and after completion of E or WP. Surgical pCR in breast and lymph nodes was determined by a local pathologist following chemotherapy. Forty-nine patients received ≥1 dose of neoadjuvant chemotherapy and are included in this analysis. Forty-eight underwent surgery; one had disease that was inoperable (on E) and is included as no-pCR patient. 17/19 of these patients who took WP completed 12 doses; 28/30 on E completed 4 cycles. Six discontinued treatment on WP, E, or AC. Both treatments were well tolerated. pCR on WP = 5/19(26 %) and on E = 5/30(17 %). Both regimens were equally well tolerated with no unexpected toxicities. pCR did not suggest higher activity with E than with other standard regimens in these LABC patients.

Efficient temporal and interlayer parameter prediction for weighted prediction in scalable high efficiency video coding

NASA Astrophysics Data System (ADS)

Tsang, Sik-Ho; Chan, Yui-Lam; Siu, Wan-Chi

2017-01-01

Weighted prediction (WP) is an efficient video coding tool that was introduced since the establishment of the H.264/AVC video coding standard, for compensating the temporal illumination change in motion estimation and compensation. WP parameters, including a multiplicative weight and an additive offset for each reference frame, are required to be estimated and transmitted to the decoder by slice header. These parameters cause extra bits in the coded video bitstream. High efficiency video coding (HEVC) provides WP parameter prediction to reduce the overhead. Therefore, WP parameter prediction is crucial to research works or applications, which are related to WP. Prior art has been suggested to further improve the WP parameter prediction by implicit prediction of image characteristics and derivation of parameters. By exploiting both temporal and interlayer redundancies, we propose three WP parameter prediction algorithms, enhanced implicit WP parameter, enhanced direct WP parameter derivation, and interlayer WP parameter, to further improve the coding efficiency of HEVC. Results show that our proposed algorithms can achieve up to 5.83% and 5.23% bitrate reduction compared to the conventional scalable HEVC in the base layer for SNR scalability and 2× spatial scalability, respectively.

Whey protein hydrolysate increases translocation of GLUT-4 to the plasma membrane independent of insulin in wistar rats.

PubMed

Morato, Priscila Neder; Lollo, Pablo Christiano Barboza; Moura, Carolina Soares; Batista, Thiago Martins; Camargo, Rafael Ludemann; Carneiro, Everardo Magalhães; Amaya-Farfan, Jaime

2013-01-01

Whey protein (WP) and whey protein hydrolysate (WPH) have the recognized capacity to increase glycogen stores. The objective of this study was to verify if consuming WP and WPH could also increase the concentration of the glucose transporters GLUT-1 and GLUT-4 in the plasma membrane (PM) of the muscle cells of sedentary and exercised animals. Forty-eight Wistar rats were divided into 6 groups (n = 8 per group), were treated and fed with experimental diets for 9 days as follows: a) control casein (CAS); b) WP; c) WPH; d) CAS exercised; e) WP exercised; and f) WPH exercised. After the experimental period, the animals were sacrificed, muscle GLUT-1 and GLUT-4, p85, Akt and phosphorylated Akt were analyzed by western blotting, and the glycogen, blood amino acids, insulin levels and biochemical health indicators were analyzed using standard methods. Consumption of WPH significantly increased the concentrations of GLUT-4 in the PM and glycogen, whereas the GLUT-1 and insulin levels and the health indicators showed no alterations. The physical exercise associated with consumption of WPH had favorable effects on glucose transport into muscle. These results should encourage new studies dealing with the potential of both WP and WPH for the treatment or prevention of type II diabetes, a disease in which there is reduced translocation of GLUT-4 to the plasma membrane.

Environmental species sorting dominates forest-bird community assembly across scales.

PubMed

Özkan, Korhan; Svenning, Jens-Christian; Jeppesen, Erik

2013-01-01

Environmental species sorting and dispersal are seen as key factors in community assembly, but their relative importance and scale dependence remain uncertain, as the extent to which communities are consistently assembled throughout their biomes. To address these issues, we analysed bird metacommunity structure in a 1200-km(2) forested landscape (Istranca Forests) in Turkish Thrace at the margin of the Western Palaearctic (WP) temperate-forest biome. First, we used spatial regressions and Mantel tests to assess the relative importance of environmental and spatial factors as drivers of local species richness and composition within the metacommunity. Second, we analysed species' abundance-occupancy relationship across the metacommunity and used null models to assess whether occupancy is determined by species' environmental niches. Third, we used generalized linear models to test for links between species' metacommunity-wide occupancy and their broader WP regional populations and assessed whether these links are consistent with environmental species sorting. There was strong environmental control on local species richness and composition patterns within the metacommunity, but non-environmental spatial factors had also an important joint role. Null model analyses on randomized communities showed that species' occupancy across the metacommunity was strongly determined by species' environmental niches, with occupancy being related to niche position marginality. Species' metacommunity-wide occupancy correlated with their local abundance as well as with their range size and total abundance for the whole WP, suggesting that the same assembly mechanisms act consistently across local to regional scales. A species specialization index that was estimated by bird species' habitat use across France, incorporating both niche position and breadth, was significantly related to species' occupancy and abundance at both metacommunity and WP regional scales. Hence, the same niche-related assembly mechanisms appear to act consistently across the WP region. Overall, our results suggest that the structure of the Istranca Forest' bird metacommunity was predominantly controlled by environmental species sorting in a manner consistent with the broader WP region. However, variability in local community structure was also linked to purely spatial factors, albeit more weakly. © 2012 The Authors. Journal of Animal Ecology © 2012 British Ecological Society.

Erratum: Correction to: Emplacement controls for the basaltic-andesitic radial dikes of Summer Coon volcano and implications for flank vents at stratovolcanoes

NASA Astrophysics Data System (ADS)

Harp, A. G.; Valentine, G. A.

2018-06-01

In the article "Emplacement controls for the basaltic-andesitic radial dikes of Summer Coon volcano and implications for flank vents at stratovolcanoes", the vertical axis for Fig. 8 a was incorrectly labeled (i.e., the value for dikes per km2).

Text Comprehension and Oral Language as Predictors of Word-Problem Solving: Insights into Word-Problem Solving as a Form of Text Comprehension

PubMed Central

Fuchs, Lynn S.; Gilbert, Jennifer K.; Fuchs, Douglas; Seethaler, Pamela M.; Martin, BrittanyLee N.

2018-01-01

This study was designed to deepen insights on whether word-problem (WP) solving is a form of text comprehension (TC) and on the role of language in WPs. A sample of 325 second graders, representing high, average, and low reading and math performance, was assessed on (a) start-of-year TC, WP skill, language, nonlinguistic reasoning, working memory, and foundational skill (word identification, arithmetic) and (b) year-end WP solving, WP-language processing (understanding WP statements, without calculation demands), and calculations. Multivariate, multilevel path analysis, accounting for classroom and school effects, indicated that TC was a significant and comparably strong predictor of all outcomes. Start-of-year language was a significantly stronger predictor of both year-end WP outcomes than of calculations, whereas start-of-year arithmetic was a significantly stronger predictor of calculations than of either WP measure. Implications are discussed in terms of WP solving as a form of TC and a theoretically coordinated approach, focused on language, for addressing TC and WP-solving instruction. PMID:29643723

Word problems: a review of linguistic and numerical factors contributing to their difficulty

PubMed Central

Daroczy, Gabriella; Wolska, Magdalena; Meurers, Walt Detmar; Nuerk, Hans-Christoph

2015-01-01

Word problems (WPs) belong to the most difficult and complex problem types that pupils encounter during their elementary-level mathematical development. In the classroom setting, they are often viewed as merely arithmetic tasks; however, recent research shows that a number of linguistic verbal components not directly related to arithmetic contribute greatly to their difficulty. In this review, we will distinguish three components of WP difficulty: (i) the linguistic complexity of the problem text itself, (ii) the numerical complexity of the arithmetic problem, and (iii) the relation between the linguistic and numerical complexity of a problem. We will discuss the impact of each of these factors on WP difficulty and motivate the need for a high degree of control in stimuli design for experiments that manipulate WP difficulty for a given age group. PMID:25883575

Synthesis of Zr2WP2O12/ZrO2 Composites with Adjustable Thermal Expansion.

PubMed

Zhang, Zhiping; Sun, Weikang; Liu, Hongfei; Xie, Guanhua; Chen, Xiaobing; Zeng, Xianghua

2017-01-01

Zr 2 WP 2 O 12 /ZrO 2 composites were fabricated by solid state reaction with the goal of tailoring the thermal expansion coefficient. XRD, SEM and TMA were used to investigate the composition, microstructure, and thermal expansion behavior of Zr 2 WP 2 O 12 /ZrO 2 composites with different mass ratio. Relative densities of all the resulting Zr 2 WP 2 O 12 /ZrO 2 samples were also tested by Archimedes' methods. The obtained Zr 2 WP 2 O 12 /ZrO 2 composites were comprised of orthorhombic Zr 2 WP 2 O 12 and monoclinic ZrO 2 . As the increase of the Zr 2 WP 2 O 12 , the relative densities of Zr 2 WP 2 O 12 /ZrO 2 ceramic composites increased gradually. The coefficient of thermal expansion of the Zr 2 WP 2 O 12 /ZrO 2 composites can be tailored from 4.1 × 10 -6 K -1 to -3.3 × 10 -6 K -1 by changing the content of Zr 2 WP 2 O 12 . The 2:1 Zr 2 WP 2 O 12 /ZrO 2 specimen shows close to zero thermal expansion from 25 to 700°C with an average linear thermal expansion coefficient of -0.09 × 10 -6 K -1 . These adjustable and near zero expansion ceramic composites will have great potential application in many fields.

Word Processing Curriculum Guide.

ERIC Educational Resources Information Center

Anderson, Marcia A.; Kusek, Robert W.

A combination of facts, examples, models, tools, and sources useful in developing and teaching word processing (WP) programs is provided in this guide. Eight sections are included. Sections 1 and 2 present introductory information on WP (e.g., history, five phases of WP, problems occurring in WP offices, factors of people, procedures, and…

Patients with Concomitant Chronic Neck Pain and Myofascial Pain in Masticatory Muscles Have More Widespread Pain and Distal Hyperalgesia than Patients with Only Chronic Neck Pain.

PubMed

Muñoz-García, Daniel; López-de-Uralde-Villanueva, Ibai; Beltrán-Alacreu, Héctor; La Touche, Roy; Fernández-Carnero, Josué

2017-03-01

Insufficient evidence exists to compare widespread pain (WP), pain sensibility, and psychological factors that occur in patients presenting with chronic neck pain (CNP) or a combination of temporomandibular disorder (TMD) and other complaints. The present study compared the pain sensibility and psychological factors of subjects with CNP with those with TMD + CNP. Cross-sectional study. Local community. A nonprobabilistic convenience sample of 86 persons with CNP or TMD was recruited into three groups: CNP, TMD with myofascial pain in masticatory muscles with cocomitant CNP (TMD + CNP), and asymptomatic control groups consisted of 27, 29, and 30 participants, respectively. Participants underwent a clinical examination to evaluate WP with computerized assessment based on the pain drawing, pressure pain thresholds (PPT), and psychological factors, which were evaluated using the pain catastrophizing scale (PCS) and the state-trait anxiety inventory (STAI). Statistically significant differences were observed between participants with CNP and TMD + CNP for WP (t = -2.80, P  < 0.01, d = -1.06). Post hoc analyses only revealed significant differences between TMD + CNP participants and asymptomatic controls for PPT at extratrigeminal areas. Pearson correlation analyses showed a moderate positive association between symptomatic groups within the WP and STAI ( P  < 0.05) and a moderate negative association between PCS and PPT ( P  < 0.05) at the right tibialis muscle. TMD + CNP participants had more areas of pain and also showed widespread pain hyperalgesia. Both groups of participants had psychological factors positively associated with STAI and WP; further, PCS and the PPT at the extratrigeminal region were negatively associated with each other in both groups, except for the left tibialis in the TMD + CNP group. © 2016 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Efficacy of three formulations of diflubenzuron, an insect growth regulator, against Culex quinquefasciatus Say, the vector of Bancroftian filariasis in India

PubMed Central

Sadanandane, C.; Doss, P. S. Boopathi; Jambulingam, P.

2012-01-01

Background & objectives: Insect growth regulators (IGRs) offer alternatives to conventional chemical larvicides that pose problem of resistance and environmental safety. However, only a limited number of IGRs have been approved for use in mosquito control. In the present study, two new formulations of the IGR diflubenzuron, 2 per cent granular (GR) and 2 per cent tablet (DT) were tested for its efficacy against Culex quinquefasciatus, in comparison to its 25 per cent wettable powder (WP) formulation. Methods: The WP, GR and DT formulations were tested in cesspits, street drains and abandoned wells each at four dosages, 25, 50, 75 and 100 g ai/ha. Additionally, the DT formulation was tested at a higher dosage of 1 tablet/m2 (equal to 400 g ai/ha). Results: The WP and GR formulations yielded >80 per cent inhibition of adult emergence (IE) for 7-10 days in cesspits, 4-7 days in street drains and 7-21 days in abandoned wells at all dosages tested. The DT formulation was effective only at higher dosage 100 g ai/ha and or 1 tablet/m2 for 7-15 days at all habitats. Interpretation & conclusions: The trial showed that the dosage 25 g ai/ha of 25 per cent WP could be the field dosage for cesspits and wells, and 50 g ai/ha for drains, to be applied at weekly intervals. The dosages 25, 50 and 100 g ai/ha of 2 per cent GR could be the field dosages for application in cesspits at weekly intervals, in abandoned wells every three weeks and in drains at weekly intervals, respectively. Diflubenzuron 25 per cent WP and 2 per cent GR could be used for larval control of Cx. quinquefasciatus under integrated vector management programme. PMID:23287125

Influence of Pre- and Postharvest Summer Pruning on the Growth, Yield, Fruit Quality, and Carbohydrate Content of Early Season Peach Cultivars

PubMed Central

Ikinci, Ali

2014-01-01

Winter and summer pruning are widely applied processes in all fruit trees, including in peach orchard management. This study was conducted to determine the effects of summer prunings (SP), as compared to winter pruning (WP), on shoot length, shoot diameter, trunk cross sectional area (TCSA) increment, fruit yield, fruit quality, and carbohydrate content of two early ripening peach cultivars (“Early Red” and “Maycrest”) of six years of age, grown in semiarid climate conditions, in 2008 to 2010. The trees were grafted on GF 677 rootstocks, trained with a central leader system, and spaced 5 × 5 m apart. The SP carried out after harvesting in July and August decreased the shoot length significantly; however, it increased its diameter. Compared to 2009, this effect was more marked in year 2010. In general, control and winter pruned trees of both cultivars had the highest TCSA increment and yield efficiency. The SP increased the average fruit weight and soluble solids contents (SSC) more than both control and WP. The titratable acidity showed no consistent response to pruning time. The carbohydrate accumulation in shoot was higher in WP and in control than in SP trees. SP significantly affected carbohydrate accumulation; postharvest pruning showed higher carbohydrate content than preharvest pruning. PMID:24737954

Waterpipe (Hookah) Smoking Among Youth and Women in Canada is New, not Traditional.

PubMed

Hammal, Fadi; Wild, T Cameron; Nykiforuk, Candace; Abdullahi, Khadija; Mussie, Dawit; Finegan, Barry A

2016-05-01

When asserting the right of individuals to be free to smoke a hookah (waterpipe [WP]) in public places, the "cultural" importance of the practice is often cited. The purpose of this study was to explore the cultural significance of WP smoking. Qualitative methods were used to elicit the views of groups of WP smokers from different cultural backgrounds. Sixteen group discussion sessions with a total of 75 WP smokers aged between 18 and 30 were conducted. A few participants saw culture as a factor supporting WP smoking initiation and maintenance. The vast majority indicated that WPs being perceived as "healthier" than cigarettes, and the availability of flavored shisha as important factors in their initiation and ongoing use. Most started smoking before the age of 18 calling it a "high school thing" and admitted that they had easy access to WP cafés. Many indicated that they did not know if they were smoking tobacco or a "herbal" substance. Peer influence, availability of flavored products and facile access to WP cafés are major factors in WP initiation. Ethno-cultural traditions play only a minor role. The assertion that cultural traditions and practice are inherent in WP smoking as implied by media and marketing was not supported by our findings. Contemporary use of WP is spreading among new non-traditional users. Lack of knowledge about the harms of WP smoking indicates a need for education and regulation to require packaging and health warning labels and restrictions on access, especially to minors. © The Author 2015. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

2007 Wholesale Power Rate Case Initial Proposal : Wholesale Power Rate Development Study.

DOE Office of Scientific and Technical Information (OSTI.GOV)

United States. Bonneville Power Administration.

The Wholesale Power Rate Development Study (WPRDS) calculates BPA proposed rates based on information either developed in the WPRDS or supplied by the other studies that comprise the BPA rate proposal. All of these studies, and accompanying documentation, provide the details of computations and assumptions. In general, information about loads and resources is provided by the Load Resource Study (LRS), WP-07-E-BPA-01, and the LRS Documentation, WP-07-E-BPA-01A. Revenue requirements information, as well as the Planned Net Revenues for Risk (PNNR), is provided in the Revenue Requirement Study, WP-07-E-BPA-02, and its accompanying Revenue Requirement Study Documentation, WP-07-E-BPA-02A and WP-07-E-BPA-02B. The Market Pricemore » Forecast Study (MPFS), WP-07-E-BPA-03, and the MPFS Documentation, WP-07-E-BPA-03A, provide the WPRDS with information regarding seasonal and diurnal differentiation of energy rates, as well information regarding monthly market prices for Demand Rates. In addition, this study provides information for the pricing of unbundled power products. The Risk Analysis Study, WP-07-E-BPA-04, and the Risk Analysis Study Documentation, WP-07-E-BPA-04A, provide short-term balancing purchases as well as secondary energy sales and revenue. The Section 7(b)(2) Rate Test Study, WP-07-E-BPA-06, and the Section 7(b)(2) Rate Test Study Documentation, WP-07-E-BPA-06A, implement Section 7(b)(2) of the Northwest Power Act to ensure that BPA preference customers firm power rates applied to their general requirements are no higher than rates calculated using specific assumptions in the Northwest Power Act.« less

Springtime trans-Pacific transport of Asian pollutants characterized by the Western Pacific (WP) pattern

NASA Astrophysics Data System (ADS)

Koo, Ja-Ho; Kim, Jaemin; Kim, Jhoon; Lee, Hanlim; Noh, Young Min; Lee, Yun Gon

2016-12-01

Springtime trans-Pacific transport of Asian air pollutants has been investigated in many ways to figure out its mechanism. Based on the Western Pacific (WP) pattern, one of climate variabilities in the Northern Hemisphere known to be associated with the pattern of atmospheric circulation over the North Pacific Ocean, in this study, we characterize the pattern of springtime trans-Pacific transport using long-term satellite measurements and reanalysis datasets. A positive WP pattern is characterized by intensification of the dipole structure between the northern Aleutian Low and the southern Pacific High over the North Pacific. The TOMS/OMI Aerosol Index (AI) and MOPITT CO show the enhancement of Asian pollutant transport across the Pacific during periods of positive WP pattern, particularly between 40 and 50°N. This enhancement is confirmed by high correlations of WP index with AI and CO between 40 and 50°N. To evaluate the influence of the WP pattern, we examine several cases of trans-Pacific transport reported in previous research. Interestingly, most trans-Pacific transport cases are associated with the positive WP pattern. During the period of negative WP pattern, reinforced cyclonic wave breaking is consistently found over the western North Pacific, which obstructs zonal advection across the North Pacific. However, some cases show the trans-Pacific transport of CO in the period of negative WP pattern, implying that the WP pattern is more influential on the transport of particles mostly emitted near ∼40°N. This study reveals that the WP pattern can be utilized to diagnose the strength of air pollutant transport from East Asia to North America.

United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU).

PubMed

Löhr, J Matthias; Dominguez-Munoz, Enrique; Rosendahl, Jonas; Besselink, Marc; Mayerle, Julia; Lerch, Markus M; Haas, Stephan; Akisik, Fatih; Kartalis, Nikolaos; Iglesias-Garcia, Julio; Keller, Jutta; Boermeester, Marja; Werner, Jens; Dumonceau, Jean-Marc; Fockens, Paul; Drewes, Asbjorn; Ceyhan, Gürlap; Lindkvist, Björn; Drenth, Joost; Ewald, Nils; Hardt, Philip; de Madaria, Enrique; Witt, Heiko; Schneider, Alexander; Manfredi, Riccardo; Brøndum, Frøkjer J; Rudolf, Sasa; Bollen, Thomas; Bruno, Marco

2017-03-01

There have been substantial improvements in the management of chronic pancreatitis, leading to the publication of several national guidelines during recent years. In collaboration with United European Gastroenterology, the working group on 'Harmonizing diagnosis and treatment of chronic pancreatitis across Europe' (HaPanEU) developed these European guidelines using an evidence-based approach. Twelve multidisciplinary review groups performed systematic literature reviews to answer 101 predefined clinical questions. Recommendations were graded using the Grading of Recommendations Assessment, Development and Evaluation system and the answers were assessed by the entire group in a Delphi process online. The review groups presented their recommendations during the 2015 annual meeting of United European Gastroenterology. At this one-day, interactive conference, relevant remarks were voiced and overall agreement on each recommendation was quantified using plenary voting (Test and Evaluation Directorate). After a final round of adjustments based on these comments, a draft version was sent out to external reviewers. The 101 recommendations covered 12 topics related to the clinical management of chronic pancreatitis: aetiology (working party (WP)1), diagnosis of chronic pancreatitis with imaging (WP2 and WP3), diagnosis of pancreatic exocrine insufficiency (WP4), surgery in chronic pancreatitis (WP5), medical therapy (WP6), endoscopic therapy (WP7), treatment of pancreatic pseudocysts (WP8), pancreatic pain (WP9), nutrition and malnutrition (WP10), diabetes mellitus (WP11) and the natural course of the disease and quality of life (WP12). Using the Grading of Recommendations Assessment, Development and Evaluation system, 70 of the 101 (70%) recommendations were rated as 'strong' and plenary voting revealed 'strong agreement' for 99 (98%) recommendations. The 2016 HaPanEU/United European Gastroenterology guidelines provide evidence-based recommendations concerning key aspects of the medical and surgical management of chronic pancreatitis based on current available evidence. These recommendations should serve as a reference standard for existing management of the disease and as a guide for future clinical research.

Wikipedia as a gateway to biomedical research: The relative distribution and use of citations in the English Wikipedia.

PubMed

Maggio, Lauren A; Willinsky, John M; Steinberg, Ryan M; Mietchen, Daniel; Wass, Joseph L; Dong, Ting

2017-01-01

Wikipedia is a gateway to knowledge. However, the extent to which this gateway ends at Wikipedia or continues via supporting citations is unknown. Wikipedia's gateway functionality has implications for information design and education, notably in medicine. This study aims to establish benchmarks for the relative distribution and referral (click) rate of citations-as indicated by presence of a Digital Object Identifier (DOI)-from Wikipedia, with a focus on medical citations. DOIs referred from the English Wikipedia in August 2016 were obtained from Crossref.org. Next, based on a DOI's presence on a WikiProject Medicine page, all DOIs in Wikipedia were categorized as medical (WP:MED) or non-medical (non-WP:MED). Using this categorization, referred DOIs were classified as WP:MED, non-WP:MED, or BOTH, meaning the DOI may have been referred from either category. Data were analyzed using descriptive and inferential statistics. Out of 5.2 million Wikipedia pages, 4.42% (n = 229,857) included at least one DOI. 68,870 were identified as WP:MED, with 22.14% (n = 15,250) featuring one or more DOIs. WP:MED pages featured on average 8.88 DOI citations per page, whereas non-WP:MED pages had on average 4.28 DOI citations. For DOIs only on WP:MED pages, a DOI was referred every 2,283 pageviews and for non-WP:MED pages every 2,467 pageviews. DOIs from BOTH pages accounted for 12% (n = 58,475). The referral of DOI citations found in BOTH could not be assigned to WP:MED or non-WP:MED, as the page from which the referral was made was not provided with the data. While these results cannot provide evidence of greater citation referral from WP:MED than non-WP:MED, they do provide benchmarks to assess strategies for changing referral patterns. These changes might include editors adopting new methods for designing and presenting citations or the introduction of teaching strategies that address the value of consulting citations as a tool for extending learning.

Wikipedia as a gateway to biomedical research: The relative distribution and use of citations in the English Wikipedia

PubMed Central

Willinsky, John M.; Steinberg, Ryan M.; Mietchen, Daniel; Wass, Joseph L.; Dong, Ting

2017-01-01

Wikipedia is a gateway to knowledge. However, the extent to which this gateway ends at Wikipedia or continues via supporting citations is unknown. Wikipedia’s gateway functionality has implications for information design and education, notably in medicine. This study aims to establish benchmarks for the relative distribution and referral (click) rate of citations—as indicated by presence of a Digital Object Identifier (DOI)—from Wikipedia, with a focus on medical citations. DOIs referred from the English Wikipedia in August 2016 were obtained from Crossref.org. Next, based on a DOI’s presence on a WikiProject Medicine page, all DOIs in Wikipedia were categorized as medical (WP:MED) or non-medical (non-WP:MED). Using this categorization, referred DOIs were classified as WP:MED, non-WP:MED, or BOTH, meaning the DOI may have been referred from either category. Data were analyzed using descriptive and inferential statistics. Out of 5.2 million Wikipedia pages, 4.42% (n = 229,857) included at least one DOI. 68,870 were identified as WP:MED, with 22.14% (n = 15,250) featuring one or more DOIs. WP:MED pages featured on average 8.88 DOI citations per page, whereas non-WP:MED pages had on average 4.28 DOI citations. For DOIs only on WP:MED pages, a DOI was referred every 2,283 pageviews and for non-WP:MED pages every 2,467 pageviews. DOIs from BOTH pages accounted for 12% (n = 58,475). The referral of DOI citations found in BOTH could not be assigned to WP:MED or non-WP:MED, as the page from which the referral was made was not provided with the data. While these results cannot provide evidence of greater citation referral from WP:MED than non-WP:MED, they do provide benchmarks to assess strategies for changing referral patterns. These changes might include editors adopting new methods for designing and presenting citations or the introduction of teaching strategies that address the value of consulting citations as a tool for extending learning. PMID:29267345

Papers and Proceedings. Syntopican VIII: "Moving Information--Concepts in Transition." (Minneapolis, MN, June 23-26, 1980).

ERIC Educational Resources Information Center

1980

This collection of 22 papers examines various word processing (WP) technologies, systems, and applications. The first five papers by C. Briggs, C. Taylor, G. McLean, D. Remsen, and C. Norris discuss WP applications in the Army, a WP system for an insurance firm, the organization of the International Word Processing Association, WP fundamentals,…

Dynamic of small photovoltaic systems

NASA Astrophysics Data System (ADS)

Mehrmann, A.; Kleinkauf, W.; Pigorsch, W.; Steeb, H.

The results of 1.5 yr of field-testing of two photovoltaic (PV) power plants, one equipped with an electrolyzer and H2 storage, are reported. Both systems were interconnected with the grid and featured the PV module, a power conditioning unit, ac and dc load connections, and control units. The rated power of both units was 100 Wp. The system with electrolysis was governed by control laws which maximized the electrolyzer current. The tests underscored the preference for a power conditioning unit, rather than direct output to load connections. A 1 kWp system was developed in a follow-up program and will be tested in concert with electrolysis and interconnection with several grid customers. The program is geared to eventual development of larger units for utility-size applications.

Co-ingestion of carbohydrate and whey protein increases fasted rates of muscle protein synthesis immediately after resistance exercise in rats

PubMed Central

Wang, Wanyi; Ding, Zhenping; Solares, Geoffrey J.; Choi, Soon-Mi; Wang, Bo; Yoon, Aram; Farrar, Roger P.; Ivy, John L.

2017-01-01

The objective of the study was to investigate whether co-ingestion of carbohydrate and protein as compared with protein alone augments muscle protein synthesis (MPS) during early exercise recovery. Two months old rats performed 10 repetitions of ladder climbing with 75% of body weight attached to their tails. Placebo (PLA), whey protein (WP), or whey protein plus carbohydrate (CP) was then given to rats by gavage. An additional group of sedentary rats (SED) was used as controls. Blood samples were collected immediately and at either 1 or 2 h after exercise. The flexor hallucis longus muscle was excised at 1 or 2 h post exercise for analysis of MPS and related signaling proteins. MPS was significantly increased by CP compared with PLA (p<0.05), and approached significance compared with WP at 1 h post exercise (p = 0.08). CP yielded a greater phosphorylation of mTOR compared with SED and PLA at 1 h post exercise and SED and WP at 2 h post exercise. CP also increased phosphorylation of p70S6K compared with SED at 1 and 2 h post exercise. 4E-BP1 phosphorylation was inhibited by PLA at 1 h but elevated by WP and CP at 2 h post exercise relative to SED. The phosphorylation of AMPK was elevated by exercise at 1 h post exercise, and this elevated level was sustained only in the WP group at 2 h. The phosphorylation of Akt, GSK3, and eIF2Bε were unchanged by treatments. Plasma insulin was transiently increased by CP at 1 h post exercise. In conclusion, post-exercise CP supplementation increases MPS post exercise relative to PLA and possibly WP, which may have been mediated by greater activation of the mTOR signaling pathway. PMID:28296942

50 kWp Photovoltaic Concentrator Application Experiment, Phase I. Final report, 1 June 1978-28 February 1979

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maget, H.J.R.

1979-06-15

This program consists of a design study and component development for an experimental 50-kWp photovoltaic concentrator system to supply power to the San Ramon substation of the Pacific Gas and Electric Company. The photovoltaic system is optimized to produce peaking power to relieve the air conditioning load on the PG and E system during summer afternoons; and would therefore displace oil-fired power generation capacity. No electrical storage is required. The experiment would use GaAs concentrator cells with point-focus fresnel lenses operating at 400X, in independent tracking arrays of 440 cells each, generating 3.8 kWp. Fourteen arrays, each 9 feet bymore » 33 feet, are connected electrically in series to generate the 50 kWp. The high conversion efficiency possible with GaAs concentrator cells results in a projected annual average system efficiency (AC electric power output to sunlight input) of better than 15%. The capability of GaAs cells for high temperature operation made possible the design of a total energy option, whereby thermal power from selected arrays could be used to heat and cool the control center for the installation. System design and analysis, fabrication and installation, environmental assessment, and cost projections are described in detail. (WHK)« less

Wnt-beta-catenin pathway signals metastasis-associated tumor cell phenotypes in triple negative breast cancers.

PubMed

De, Pradip; Carlson, Jennifer H; Wu, Hui; Marcus, Adam; Leyland-Jones, Brian; Dey, Nandini

2016-07-12

Tumor cells acquire metastasis-associated (MA) phenotypes following genetic alterations in them which cause deregulation of different signaling pathways. Earlier, we reported that an upregulation of the Wnt-beta-catenin pathway (WP) is one of the genetic salient features of triple-negative breast cancer (TNBC), and WP signaling is associated with metastasis in TNBC. Using cBioPortal, here we found that collective % of alteration(s) in WP genes, CTNNB1, APC and DVL1 among breast-invasive-carcinomas was 21% as compared to 56% in PAM50 Basal. To understand the functional relevance of WP in the biology of heterogeneous/metastasizing TNBC cells, we undertook this comprehensive study using 15 cell lines in which we examined the role of WP in the context of integrin-dependent MA-phenotypes. Directional movement of tumor cells was observed by confocal immunofluorescence microscopy and quantitative confocal-video-microscopy while matrigel-invasion was studied by MMP7-specific casein-zymography. WntC59, XAV939, sulindac sulfide and beta-catenin siRNA (1) inhibited fibronectin-directed migration, (2) decreased podia-parameters and motility-descriptors, (3) altered filamentous-actin, (4) decreased matrigel-invasion and (5) inhibited cell proliferation as well as 3D clonogenic growth. Sulindac sulfide and beta-catenin siRNA decreased beta-catenin/active-beta-catenin and MMP7. LWnt3ACM-stimulated proliferation, clonogenicity, fibronectin-directed migration and matrigel-invasion were perturbed by WP-modulators, sulindac sulfide and GDC-0941. We studied a direct involvement of WP in metastasis by stimulating brain-metastasis-specific MDA-MB231BR cells to demonstrate that LWnt3ACM-stimulated proliferation, clonogenicity and migration were blocked following sulindac sulfide, GDC-0941 and beta-catenin knockdown. We present the first evidence showing a direct functional relationship between WP activation and integrin-dependent MA-phenotypes. By proving the functional relationship between WP activation and MA-phenotypes, our data mechanistically explains (1) why different components of WP are upregulated in TNBC, (2) how WP activation is associated with metastasis and (3) how integrin-dependent MA-phenotypes can be regulated by mitigating the WP.

Wnt-beta-catenin pathway signals metastasis-associated tumor cell phenotypes in triple negative breast cancers

PubMed Central

De, Pradip; Carlson, Jennifer H.; Wu, Hui; Marcus, Adam; Leyland-Jones, Brian; Dey, Nandini

2016-01-01

Tumor cells acquire metastasis-associated (MA) phenotypes following genetic alterations in them which cause deregulation of different signaling pathways. Earlier, we reported that an upregulation of the Wnt-beta-catenin pathway (WP) is one of the genetic salient features of triple-negative breast cancer (TNBC), and WP signaling is associated with metastasis in TNBC. Using cBioPortal, here we found that collective % of alteration(s) in WP genes, CTNNB1, APC and DVL1 among breast-invasive-carcinomas was 21% as compared to 56% in PAM50 Basal. To understand the functional relevance of WP in the biology of heterogeneous/metastasizing TNBC cells, we undertook this comprehensive study using 15 cell lines in which we examined the role of WP in the context of integrin-dependent MA-phenotypes. Directional movement of tumor cells was observed by confocal immunofluorescence microscopy and quantitative confocal-video-microscopy while matrigel-invasion was studied by MMP7-specific casein-zymography. WntC59, XAV939, sulindac sulfide and beta-catenin siRNA (1) inhibited fibronectin-directed migration, (2) decreased podia-parameters and motility-descriptors, (3) altered filamentous-actin, (4) decreased matrigel-invasion and (5) inhibited cell proliferation as well as 3D clonogenic growth. Sulindac sulfide and beta-catenin siRNA decreased beta-catenin/active-beta-catenin and MMP7. LWnt3ACM-stimulated proliferation, clonogenicity, fibronection-directed migration and matrigel-invasion were perturbed by WP-modulators, sulindac sulfide and GDC-0941. We studied a direct involvement of WP in metastasis by stimulating brain-metastasis-specific MDA-MB231BR cells to demonstrate that LWnt3ACM-stimulated proliferation, clonogenicity and migration were blocked following sulindac sulfide, GDC-0941 and beta-catenin knockdown. We present the first evidence showing a direct functional relationship between WP activation and integrin-dependent MA-phenotypes. By proving the functional relationship between WP activation and MA-phenotypes, our data mechanistically explains (1) why different components of WP are upregulated in TNBC, (2) how WP activation is associated with metastasis and (3) how integrin-dependent MA-phenotypes can be regulated by mitigating the WP. PMID:27281609

Temporal Variations of Water Productivity in Irrigated Corn: An Analysis of Factors Influencing Yield and Water Use across Central Nebraska

PubMed Central

Carr, Tony; Yang, Haishun; Ray, Chittaranjan

2016-01-01

Water Productivity (WP) of a crop defines the relationship between the economic or physical yield of the crop and its water use. With this concept it is possible to identify disproportionate water use or water-limited yield gaps and thereby support improvements in agricultural water management. However, too often important qualitative and quantitative environmental factors are not part of a WP analysis and therefore neglect the aspect of maintaining a sustainable agricultural system. In this study, we examine both the physical and economic WP in perspective with temporally changing environmental conditions. The physical WP analysis was performed by comparing simulated maximum attainable corn yields per unit of water using the crop model Hybrid-Maize with observed data from 2005 through 2013 from 108 farm plots in the Central Platte and the Tri Basin Natural Resource Districts of Nebraska. In order to expand the WP analysis on external factors influencing yields, a second model, Maize-N, was used to estimate optimal nitrogen (N)–fertilizer rate for specific fields in the study area. Finally, a vadose zone flow and transport model, HYDRUS-1D for simulating vertical nutrient transport in the soil, was used to estimate locations of nitrogen pulses in the soil profile. The comparison of simulated and observed data revealed that WP was not on an optimal level, mainly due to large amounts of irrigation used in the study area. The further analysis illustrated year-to-year variations of WP during the nine consecutive years, as well as the need to improve fertilizer management to favor WP and environmental quality. In addition, we addressed the negative influence of groundwater depletion on the economic WP through increasing pumping costs. In summary, this study demonstrated that involving temporal variations of WP as well as associated environmental and economic issues can represent a bigger picture of WP that can help to create incentives to sustainably improve agricultural production. PMID:27575368

Comparative Toxicity and Dosimetric Profile of Whole-Pelvis Versus Prostate Bed-Only Intensity-Modulated Radiation Therapy After Prostatectomy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deville, Curtiland, E-mail: deville@uphs.upenn.edu; Vapiwala, Neha; Hwang, Wei-Ting

2012-03-15

Purpose: To assess whether whole-pelvis (WP) intensity modulated radiation therapy (IMRT) for prostate cancer (PCa) after prostatectomy is associated with increased toxicity compared to prostate-bed only (PB) IMRT. Methods and Materials: All patients (n = 67) undergoing postprostatectomy IMRT to 70.2 Gy at our institution from January 2006 to January 2009 with minimum 12-month follow-up were divided into WP (n = 36) and PB (n = 31) comparison groups. WP patients received initial pelvic nodal IMRT to 45 Gy. Pretreatment demographics, bladder and rectal dose-volume histograms, and maximum genitourinary (GU) and gastrointestinal (GI) toxicities were compared. Logistic regression models evaluatedmore » uni- and multivariate associations between pretreatment demographics and toxicities. Results: Pretreatment demographics including age and comorbidities were similar between groups. WP patients had higher Gleason scores, T stages, and preoperative prostate-specific antigen (PSA) levels, and more WP patients underwent androgen deprivation therapy (ADT). WP minimum (Dmin) and mean bladder doses, bladder volumes receiving more than 5 Gy (V5) and V20, rectal Dmin, and PB bladder and rectal V65 were significantly increased. Maximum acute GI toxicity was Grade 2 and was increased for WP (61%) vs. PB (29%) patients (p = 0.001); there was no significant difference in acute Grade {>=}2 GU toxicity (22% WP vs. 10% PB; p = 0.193), late Grade {>=}2 GI toxicity (3% WP vs. 0% PB; p = 0.678), or late Grade {>=}2 GU toxicity (28% WP vs. 19% PB; p = 0.274) with 25-month median follow-up (range, 12-44 months). On multivariate analysis, long-term ADT use was associated with Grade {>=}2 late GU toxicity (p = 0.02). Conclusion: Despite dosimetric differences in irradiated bowel, bladder, and rectum, WP IMRT resulted only in clinically significant increased acute GI toxicity in comparison to that with PB IMRT, with no differences in GU or late GI toxicity.« less

Description of 15 DNA-positive and antibody-negative "window-period" blood donations identified during prospective screening for Babesia microti.

PubMed

Moritz, Erin D; Tonnetti, Laura; Hewins, Mary Ellen; Berardi, Victor P; Dodd, Roger Y; Stramer, Susan L

2017-07-01

Blood donation screening detecting only antibodies fails to identify donors in the earliest stage of infection, before a detectable immunologic response, that is, the "window period" (WP). We present data on WP donations identified during prospective screening for Babesia microti, a transfusion-transmissible parasite of increasing concern in the United States. Blood donations collected in Connecticut, Massachusetts, Minnesota, and Wisconsin were screened using polymerase chain reaction (PCR) and arrayed fluorescence immunoassay (AFIA) to detect B. microti DNA and antibodies, respectively. Parasite loads were estimated using quantitative PCR. Red blood cell (RBC) samples were inoculated into hamsters to assess infectivity. Donors screening reactive were indefinitely deferred, tested by supplemental methods, and followed to assess DNA and antibody clearance. Demographic data from WP donors (i.e., those screening PCR positive and AFIA negative) were compared to data from other positive donors. Of 220,479 donations screened from June 2012 to August 2016, a total of 700 were positive, of which 15 (2% of positive donations or 1 per 14,699 screened donations) were confirmed WP donations. The median estimated parasite load in WP donations was 350 parasites/mL, no different than AFIA-positive and PCR-positive donors. Parasite loads in RBC samples from WP units ranged from 14 to 11,022 parasites/mL; RBC samples from three of 10 (30%) WP donations infected hamsters. The mean age of WP donors was 48 years (range, 17-75 years); three (20%) were female. WP donor demographics did not differ significantly from demographics of other donors. We report one per 15,000 B. microti WP infections in blood donors in endemic areas, demonstrating the importance of nucleic acid testing to mitigate the risk of transfusion-transmitted babesiosis. © 2017 AABB.

Dynamics and Control of a Minimally Actuated Biomimetic Vehicle: Part 1 - Aerodynamic Model (Postprint)

DTIC Science & Technology

2009-08-01

B L     LW Downstroke rcp B LWD =     xWPcp sinα+∆x B L xWPcp sinφLW cosα− y WP cp cosφLW − w 2 xWPcp cosφLW cosα + y WP cp sinφLW +∆z B L...associated with each wing and stroke are given by MBRWU = rcp B RWU × FBRWU MBRWD = rcp B RWD × FBRWD MBLWU = rcp B LWU × FBLWU MBLWD = rcp B LWD × FBLWD (14

Knowledge About the Waterpipe (Hookah), a Qualitative Assessment Among Community Workers in a Major Urban Center in Canada.

PubMed

Hammal, Fadi; Wild, T Cameron; Finegan, Barry A

2016-08-01

Waterpipe (WP) use has surged in popularity since the introduction of flavoured shisha. It is now an increasingly popular form of smoking among youth in North America. Health professionals/educators knowledge about the WP may well be inadequate. This study, using qualitative methods, sought to explore the knowledge and attitude of leaders in the community toward the WP. Family physicians, pharmacists, tobacco counsellors, social workers and educators were invited to participate in a one-one interview using open-ended questions. A total of 27 interviews were conducted. Individuals from Eastern Mediterranean backgrounds raised doubt about the overemphasised cultural significance of the WP and perceived this as a marketing strategy by industry. Most felt that WP smokers believed the WP to be less harmful than cigarettes and that the use of flavoured tobacco was motivating people to smoke. Participants believed that education should be directed at the general public and healthcare professionals, suggesting school programs and the use of social media to inform young smokers. Most thought that the current practices regarding packaging and second hand smoke exposure are confusing. They identified the lack of knowledge, poor enforcement procedures, "so called cultural aspects" and the economic impact of banning the WP on small businesses as barriers to change. Despite the awareness of an increase in WP use, our participants recognized that little has been done to curb this problem. Our findings emphasize the need for further education and better legislation to regulate WP use and availability.

[Enhancement of functional expression of wheat peroxidase WP1 in prokaryotic system by co-transforming with hemA and hemL of Esherichia coli].

PubMed

Zhang, Chao; Shan, Liwei; Su, Shuaikun; Nan, Yanni; Guo, Zhongyu; Fan, Sanhong

2012-07-01

Wheat grain peroxidase 1 (WP1) belonged to class III plant peroxidase with cofactor heme, which not only has antifungal activity, but also influences the processing quality of flour. In order to enhance functional expression of WP1 in prokaryotic system by increasing endogenous heme synthesis, we constructed a recombinant plasmid pACYC-A-L containing hemA and hemL of Esherichia coli. Then, we co-transformed it into host strain T7 Express with secretive expression vector (pMAL-p4x-WP1) or non-secretive expression vector (pET21a-MBP-WP1), respectively. The MBP-WP1 fusion protein was further purified by amylose affinity chromatography and its peroxidase activity was assayed using 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonate) (ABTS) as substrate. At 12 h after induction at 28 degree, the extracellular 5-aminolevulinic acid (5-ALA) production of T7 Express/pACYC-A-L was up to 146.73 mg/L, simultaneously the extracellular porphrins also increased dramatically. The peroxidase activity of functional MBP-WP1 obtained from T7 Express/ (pACYC-A-L + pMAL-p4x-WP1) was 14.6-folds of that purified from T7 Express/ pET21a-MBP-WP1. This study not only successfully enhanced functional expression of wheat peroxidase 1 in Esherichia coli, but also provided beneficial references for other important proteins with cofactor heme.

Whey versus soy protein diets and renal status in rats.

PubMed

Aparicio, Virginia A; Nebot, Elena; Tassi, Mohamed; Camiletti-Moirón, Daniel; Sanchez-Gonzalez, Cristina; Porres, Jesús M; Aranda, Pilar

2014-09-01

Different dietary protein sources can promote different renal statuses. We examined the effects of whey protein (WP) and soy protein (SP) intake on plasma, urinary, and morphological renal parameters in rats. One hundred and twenty Wistar rats were randomly distributed into 2 experimental groups fed with either WP or SP diets over 12 weeks. These diets were based on commercial WP or SP isolates. The urinary calcium content was higher in the WP diet compared to the SP diet group (P<.001) whereas the urinary citrate level was lower (P<.001). The urinary pH was more acidic in the WP diet group compared to the SP diet group (P<.001); however, no differences were observed between the groups for any of the renal morphological parameters analyzed (all, P>.05) or other plasma renal markers such as albumin or urea concentrations. The increase of acid and urinary calcium and the lower urinary citrate level observed in the WP diet group could increase the incidence of nephrolithiasis compared to the SP diet group. Despite the WP showed poorer acid-base profile, no significant morphological renal changes were observed. These results suggest that the use of SP instead of WP appears to promote a more alkaline plasma and urinary profile, with their consequent renal advantages.

Physical controls and depth of emplacement of igneous bodies: A review

NASA Astrophysics Data System (ADS)

Menand, Thierry

2011-03-01

The formation and growth of magma bodies are now recognised as involving the amalgamation of successive, discrete pulses such as sills. Sills would thus represent the building blocks of larger plutons ( sensu lato). Mechanical and thermal considerations on the incremental development of these plutons raise the issue of the crustal levels at which magma can stall and accumulate as sills. Reviewing the mechanisms that could a priori explain sill formation, it is shown that principal physical controls include: rigidity contrast, where sills form at the interface between soft strata overlaid by comparatively stiffer strata; rheology anisotropy, where sills form within the weakest ductile zones; and rotation of deviatoric stress, where sills form when the minimum compressive stress becomes vertical. Comparatively, the concept of neutral buoyancy is unlikely to play a leading control in the emplacement of sills, although it could assist their formation. These different controls on sill formation, however, do not necessarily operate on the same length scale. The length scale associated with the presence of interfaces separating upper stiffer layers from lower softer ones determines the depth at which rigidity-controlled sills will form. On another hand, the emplacement depths for rheology-controlled sills are likely to be determined by the distribution of the weakest ductile zones. Whereas the emplacement depth of stress-controlled sills is determined by a balance between the horizontal maximum compressive stress, which favours sill formation, and the buoyancy of their feeder dykes, which drives magma vertically. Ultimately, the depth at which a sill forms depends on whether crustal anisotropy or stress rotation is the dominant control, i.e. which of these processes operates at the smallest length scale. Using dimensional analysis, it is shown that sill formation controlled by remote stress rotation would occur on length scales of hundreds of meters or greater. This therefore suggests that crustal heterogeneities and their associated anisotropy are likely to play a larger role than remote stress rotation in controlling sill emplacement, unless these heterogeneities are several hundred meters or more apart. This also reinforces the role of local stress barriers, owing to interactions between deviatoric stress and crustal heterogeneities, in the formation of sills.

Improvements in musculoskeletal health and computing behaviors: Effects of a macroergonomics office workplace and training intervention.

PubMed

Robertson, Michelle M; Huang, Yueng Hsiang; Lee, Jin

2017-07-01

Computer use and its association with musculoskeletal and visual symptoms is an escalating concern. Organizations are shifting to a more proactive injury prevention perspective. Accordingly, a macroergonomics intervention consisting of flexible workplace design and office ergonomics training was designed to examine the effects on worker's computing behaviors, postures, and musculoskeletal discomfort, and their relationship to psychosocial factors. Participants were assigned to either group: 1) no-intervention control 2) flexible Workplace-only (WP-only), and 3) flexible Workplace + Training (WP+T). Observational findings indicate both intervention groups experienced positive, significant changes in improved workstation arrangements and computing postures, with the WP+T intervention group exhibiting a higher, significant change of behavioral translation. Also, significant, positive relationships between observed postures and musculoskeletal discomfort/pain were found. The intervention effect was stronger when management was responsive to workers' ergonomics needs. This study suggests that a macroergonomics intervention can produce beneficial effects for office and computer workers and organizations. Copyright © 2017 Elsevier Ltd. All rights reserved.

75 FR 51332 - Eleventh Meeting: RTCA Special Committee 209: In Joint Session With EUROCAE WG-49: ATCRBS/Mode S...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-19

... of the Minutes of Meeting 10 (SC209-WP11-02) Review of the Status of Open Action Items AI-10-11--Review of Documents for P5 Pulse Position Differences (WP11-03) AI-10-03--Issues Related to Zeroing Registers 08 16 & 20 16 (WP11-04) AI-10-02--Register 60 16 Maximum Update Interval Changes (WP11-05) AI-10...

Bis-anthracycline WP760 abrogates melanoma cell growth by transcription inhibition, p53 activation and IGF1R downregulation.

PubMed

Olbryt, Magdalena; Rusin, Aleksandra; Fokt, Izabela; Habryka, Anna; Tudrej, Patrycja; Student, Sebastian; Sochanik, Aleksander; Zieliński, Rafał; Priebe, Waldemar

2017-10-01

Anthracycline chemotherapeutics, e.g. doxorubicin and daunorubicin, are active against a broad spectrum of cancers. Their cytotoxicity is mainly attributed to DNA intercalation, interference with topoisomerase activity, and induction of double-stranded DNA breaks. Since modification of anthracyclines can profoundly affect their pharmacological properties we attempted to elucidate the mechanism of action, and identify possible molecular targets, of bis-anthracycline WP760 which previously demonstrated anti-melanoma activity at low nanomolar concentrations. We studied the effect of WP760 on several human melanoma cell lines derived from tumors in various development stages and having different genetic backgrounds. WP760 inhibited cell proliferation (IC 50  = 1-99 nM), impaired clonogenic cell survival (100 nM), and inhibited spheroid growth (≥300 nM). WP760 did not induce double-stranded DNA breaks but strongly inhibited global transcription. Moreover, WP760 caused nucleolar stress and led to activation of the p53 pathway. PCR array analysis showed that WP760 suppressed transcription of ten genes (ABCC1, MTOR, IGF1R, EGFR, GRB2, PRKCA, PRKCE, HDAC4, TXNRD1, AKT1) associated with, inter alia, cytoprotective mechanisms initiated in cancer cells during chemotherapy. Furthermore, WP760 downregulated IGF1R and upregulated PLK2 expression in most of the tested melanoma cell lines. These results suggest that WP760 exerts anti-melanoma activity by targeting global transcription and activation of the p53 pathway and could become suitable as an effective therapeutic agent.

Effects of 18-week in-season heavy-resistance and power training on throwing velocity, strength, jumping, and maximal sprint swim performance of elite male water polo players.

PubMed

Ramos Veliz, Rafael; Requena, Bernardo; Suarez-Arrones, Luis; Newton, Robert U; Sáez de Villarreal, Eduardo

2014-04-01

We examined the effects of 18 weeks of strength and high-intensity training on key sport performance measures of elite male water polo (WP) players. Twenty-seven players were randomly assigned to 2 groups, control (in-water training only) and strength group, (strength training sessions [twice per week] + in-water training). In-water training was conducted 5 d·wk. Twenty-meter maximal sprint swim, maximal dynamic strength 1-repetition maximum (1RM) for upper bench press (BP) and lower full squat (FS) body, countermovement jump (CMJ), and throwing velocity were measured before and after the training. The training program included upper and lower body strength and high-intensity exercises (BP, FS, military press, pull-ups, CMJ loaded, and abs). Baseline-training results showed no significant differences between the groups in any of the variables tested. No improvement was found in the control group; however, meaningful improvement was found in all variables in the experimental group: CMJ (2.38 cm, 6.9%, effect size [ES] = 0.48), BP (9.06 kg, 10.53%, ES = 0.66), FS (11.06 kg, 14.21%, ES = 0.67), throwing velocity (1.76 km·h(-1), 2.76%, ES = 0.25), and 20-m maximal sprint swim (-0.26 seconds, 2.25%, ES = 0.29). Specific strength and high-intensity training in male WP players for 18 weeks produced a positive effect on performance qualities highly specific to WP. Therefore, we propose modifications to the current training methodology for WP players to include strength and high-intensity training for athlete preparation in this sport.

Effect of plant growth-promoting rhizobacteria (PGPRs) on plant growth, yield, and quality of tomato (Lycopersicon esculentum Mill.) under simulated seawater irrigation.

PubMed

Shen, Min; Jun Kang, Yi; Li Wang, Huan; Sheng Zhang, Xiang; Xin Zhao, Qing

2012-01-01

To determine the effects of three PGPRs on plant growth, yield, and quality of tomato under simulated seawater irrigation, a two consecutive seasons' field experiment was conducted in Yancheng Teachers University plot from April to June and August to October, 2011. The results showed that Erwinia persicinus RA2 containing ACC deaminase exhibited the best ability compared with Bacillus pumilus WP8 and Pseudomonas putida RBP1 which had no ACC deaminase activity to enhance marketable yields of fresh and dried fruits in tomato under simulated seawater irrigation especially under HS condition. B. pumilus WP8 had significant effects on improving tomato fruit quality under the conditions of irrigating with 1.0% NaCl solution (MS) and with 2.0% NaCl solution (HS). Na(+) contents were generally accumulated much more in tomato plant mid-shoot leaves than in fruits whatever the salt concentration. More sodium accumulation in leaves of E. persicinus RA2 and B. pumilus WP8 treatments under HS condition were found than in control. E. persicinus RA2 and B. pumilus WP8 can promote tomato growth, improve fruit quality more firmly than P. putida RBP1 during two consecutive seasons. Our study suggested that E. persicinus RA2 and B. pumilus WP8 are considered to be promising PGPR strains which are suited for application in salt marsh planting, ACC deaminase activity was not unique index on screening for PGPRs with the aim of salt stress tolerance, and plant growth promoting activities may be relevant to different growth indices and different stress conditions.

Association analysis of the beta-3 adrenergic receptor Trp64Arg (rs4994) polymorphism with urate and gout.

PubMed

Fatima, Tahzeeb; Altaf, Sara; Phipps-Green, Amanda; Topless, Ruth; Flynn, Tanya J; Stamp, Lisa K; Dalbeth, Nicola; Merriman, Tony R

2016-02-01

The Arg64 allele of variant rs4994 (Trp64Arg) in the β3-adrenergic receptor gene has been associated with increased serum urate and risk of gout. Our objective was to investigate the relationship of rs4994 with serum urate and gout in New Zealand European, Māori and Pacific subjects. A total of 1730 clinically ascertained gout cases and 2145 controls were genotyped for rs4994 by Taqman(®). Māori and Pacific subjects were subdivided into Eastern Polynesian (EP) and Western Polynesian (WP) sample sets. Publicly available genotype data from the Atherosclerosis Risk in Communities Study and the Framingham Heart Study were utilized for serum urate association analysis. Multivariate logistic and linear regression adjusted for potential confounders was carried out using R version 2.15.2. No significant association of the minor Arg64 (G) allele of rs4994 with gout was found in the combined Polynesian cohorts (OR = 0.98, P = 0.88), although there was evidence, after adjustment for renal disease, for association in both the WP (OR = 0.53, P = 0.03) and the lower Polynesian ancestry EP sample sets (OR = 1.86, P = 0.05). There was no evidence for association with gout in the European sample set (OR = 1.11, P = 0.57). However, the Arg64 allele was positively associated with urate in the WP data set (β = 0.036, P = 0.004, P Corrected = 0.032). Association of the Arg64 variant with increased urate in the WP sample set was consistent with the previous literature, although the protective effect of this variant with gout in WP was inconsistent. This association provides an etiological link between metabolic syndrome components and urate homeostasis.

Importance of a diffusion-dominant small volume to activate cell-secreted soluble factor signaling in embryonic stem cell culture in microbioreactors: a mathematical model based study.

PubMed

Chowdhury, Mohammad Mahfuz; Fujii, Teruo; Sakai, Yasuyuki

2013-07-01

In our previous studies, we observed that cell-secreted BMP4 had a prominent influence on mouse embryonic stem cell (mESC) behaviors in a membrane-based two-chambered microbioreactor (MB), but not in a macro-scale culture (6-well plate/6WP). In this study, we investigated how the physical aspects of these cultures regulated BMP4 signaling by developing mathematical models of the cultures. The models estimated signaling activity in the cultures by considering size of the undifferentiated mESC colonies and their growth, diffusion of BMP4, and BMP4 trafficking process in the colonies. The models successfully depicted measured profile of BMP4 concentration in the culture medium which was two times higher in the MB than that in the 6WP during 5-day culture. The models estimated that, owing to the small volume and the membrane, cells were exposed to a higher BMP4 concentration in the top chamber of the MB than that in the 6WP culture. The higher concentration of BMP4 induced a higher concentration of BMP4-bound receptor in the colony in the MB than in the 6WP, thereby leading to the higher activation of BMP4 signaling in the MB. The models also predicted that the size of the MB, but not that of the 6WP, was suitable for maximizing BMP4 accumulation and upregulating its signaling. This study will be helpful in analyzing culture systems, designing microfluidic devices for controlling ESC or other cell behavior. Copyright © 2013 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Influence of the Western Pacific teleconnection pattern on Western North Pacific tropical cyclone activity

NASA Astrophysics Data System (ADS)

Choi, Ki-Seon; Moon, Il-Ju

2012-09-01

This study analyzes the characteristics of Western North Pacific (WNP) tropical cyclone (TC) activity and large-scale environments according to the Western Pacific (WP) teleconnection pattern in summer. In the positive WP phase, an anomalous cyclone and an anomalous anticyclone develop in the low and middle latitudes of the East Asia area, respectively. As a result, southeasterlies are reinforced in the northeast area of East Asia (including Korea and Japan), which facilitates the movement of TC to this area, whereas northwesterlies are reinforced in the southwest area of East Asia (including southern China and the Indochina Peninsula) which blocks the movement of TC to that area. Due to the spatial distribution of this reinforced pressure system, TCs that develop during the positive WP phase move and turn more to the northeast of the WNP than TCs which develop during the negative WP phase. The characteristics of this TC activity during the positive WP phase are associated with the upper tropospheric jet being located farther to the northeast. TCs during the negative WP phase mainly move to the west from the Philippines toward southern China and the Indochina Peninsula. Due to the terrain effect caused by the passage of TCs in mainland China, the intensity of TCs during the negative WP phase is weaker than those during the positive WP phase.

Encephalopathy after whole-cell pertussis or measles vaccination: lack of evidence for a causal association in a retrospective case-control study.

PubMed

Ray, Paula; Hayward, Jean; Michelson, David; Lewis, Edwin; Schwalbe, Joan; Black, Steve; Shinefield, Henry; Marcy, Michael; Huff, Ken; Ward, Joel; Mullooly, John; Chen, Robert; Davis, Robert

2006-09-01

Whole-cell pertussis (wP) and measles vaccines are effective in preventing disease but have also been suspected of increasing the risk of encephalopathy or encephalitis. Although many countries now use acellular pertussis vaccines, wP vaccine is still widely used in the developing world. It is therefore important to evaluate whether wP vaccine increases the risk of neurologic disorders. A retrospective case-control study was performed at 4 health maintenance organizations. Records from January 1, 1981, through December 31, 1995, were examined to identify children aged 0 to 6 years old hospitalized with encephalopathy or related conditions. The cause of the encephalopathy was categorized as known, unknown or suspected but unconfirmed. Up to 3 controls were matched to each case. Conditional logistic regression was used to analyze the relative risk of encephalopathy after vaccination with diphtheria-tetanus-pertussis (DTP) or measles-mumps-rubella (MMR) vaccines in the 90 days before disease onset as defined by chart review compared with an equivalent period among controls indexed by matching on case onset date. Four-hundred fifty-two cases were identified. Cases were no more likely than controls to have received either vaccine during the 90 days before disease onset. When encephalopathies of known etiology were excluded, the odds ratio for case children having received DTP within 7 days before onset of disease was 1.22 (95% confidence interval [CI] = 0.45-3.31, P = 0.693) compared with control children. For MMR in the 90 days before onset of encephalopathy, the odds ratio was 1.23 (95% confidence interval = 0.51-2.98, P = 0.647). In this study of more than 2 million children, DTP and MMR vaccines were not associated with an increased risk of encephalopathy after vaccination.

The role of declining summer sea ice extent in increasing Arctic winter precipitation

NASA Astrophysics Data System (ADS)

Hamman, J.; Roberts, A.; Cassano, J. J.; Nijssen, B.

2016-12-01

In the past three decades, the Arctic has experienced large declines in summer sea ice cover, permafrost extent, and spring snow cover, and increases in winter precipitation. This study explores the relationship between declining Arctic sea ice extent (IE) and winter precipitation (WP) across the Arctic land masses. The first part of this presentation presents the observed relationship between IE and WP. Using satellite estimates of IE and WP data based on a combination of in-situ observations and global reanalyses, we show that WP is negatively correlated with summer IE and that this relationship is strongest before the year 2000. After 2000, around the time IE minima began to decline most rapidly, the relationship between IE and WP degenerates. This indicates that other processes are driving changes in IE and WP. We hypothesize that positive anomalies in poleward moisture transport have historically driven anomalously low IE and high WP, and that since the significant decline in IE, moisture divergence from the central Arctic has been a larger contributor to WP over land. To better understand the physical mechanisms driving the observed changes in the Arctic climate system and the sensitivity of the Arctic climate system to declining sea ice, we have used the fully-coupled Regional Arctic System Model (RASM) to simulate two distinct sea ice climates. The first climate represents normal IE, while the second includes reduced summer IE. The second portion of this presentation analyzes these two RASM simulations, in conjunction with our observation-based analysis, to understand the coupled relationship between poleward moisture transport, IE, evaporation from the Arctic Ocean, and precipitation. We will present the RASM-simulated Arctic water budget and demonstrate the role of IE in driving WP anomalies. Finally, a spatial correlation analysis identifies characteristic patterns in IE, ocean evaporation, and polar cap convergence that contribute to anomalies in WP.

Wine grape pomace as antioxidant dietary fibre for enhancing nutritional value and improving storability of yogurt and salad dressing.

PubMed

Tseng, Angela; Zhao, Yanyun

2013-05-01

Wine grape pomace (WGP) as a source of antioxidant dietary fibre (ADF) was fortified in yogurt (Y), Italian (I) and Thousand Island (T) salad dressings. During the 3 weeks of storage at 4 °C, viscosity and pH of WGP-Y increased and decreased, respectively, but syneresis and lactic acid percentage of WGP-Y and pH of WGP-I and WGP-T were stable. Adding WGP resulted in 35-65% reduction of peroxide values in all samples. Dried whole pomace powder (WP) fortified products had dietary fibre content of 0.94-3.6% (w/w product), mainly insoluble fractions. Total phenolic content and DPPH radical scavenging activity were 958-1340 mg GAE/kg product and 710-936 mg AAE/kg product, respectively. The highest ADF was obtained in 3% WP-Y, 1% WP-I and 2% WP-T, while 1% WP-Y, 0.5% WP-I and 1% WP-T were mostly liked by consumers based on the sensory study. Study demonstrated that WGP may be used as a functional food ingredient for promoting human health and extending shelf-life of food products. Copyright © 2012 Elsevier Ltd. All rights reserved.

Potential of kaolin-based particle film barriers for Formosan subterranean termite (Isoptera: Rhinotermitidae) control

USGS Publications Warehouse

Wiltz, B.A.; Woodson, W.D.; Puterka, G.J.

2010-01-01

Effects of three particle film products on Formosan subterranean termites, Coptotermes formosanus Shiraki, were evaluated in feeding, tunneling, and contact assays. The particle films, hydrophobic M96-018 and hydrophilic Surround and Surround WP are based on the inert clay mineral kaolin. In 2-week long no-choice feeding tests, significant mortality occurred only with M96-018-coated wood. When a choice was provided, M96-018 and Surround were consumed at higher rates than untreated wood. Surround WP did not differ from controls in either test. In the tunneling assay termites were given the option of crossing a kaolin-sand mixture to reach an alternate food source. After 3-weeks, rates of 1% and 5% M96-018 provided an effective barrier to Formosan termite tunneling, while termites were not stopped by rates as high as 20% Surround and Surround WP. Dust treatments of all three formulations caused significant increases in mortality within 24 h, with mortality rates ranging from 72.0 - 97.3% within 72 h of treatment. The particle films were most effective when moisture levels were low, suggesting that desiccation was the mechanism for mortality. All particle films showed potential for use in above ground applications while hydrophobic M06-018 has the most potential as a soil barrier to subterranean termites.

Myoprotective Potential of Creatine Is Greater than Whey Protein after Chemically-Induced Damage in Rat Skeletal Muscle

PubMed Central

Cooke, Matthew B.; Stathis, Christos G.; Hayes, Alan

2018-01-01

The myoprotective effects of creatine monohydrate (CR) and whey protein (WP) are equivocal, with the use of proxy measures of muscle damage making interpretation of their effectiveness limited. The purpose of the study was to determine the effects of CR and WP supplementation on muscle damage and recovery following controlled, chemically-induced muscle damage. Degeneration of the extensor digitorum longus (EDL) muscle was induced by bupivacaine in rats supplemented with either CR, WP, or standard rat chow (CON). At day 7 and 14 post-myotoxic injury, injured EDL muscles were surgically removed and tested for isometric contractile properties, followed by the contralateral, non-injured EDL muscle. At the completion of testing, muscles were snap-frozen in liquid nitrogen and stored for later analysis. Data were analyzed using analysis of variance. Creatine-supplemented muscles displayed a greater proportion of non-damaged (intact) fibers (p = 0.002) and larger cross-sectional areas of regenerating and non-damaged fibers (p = 0.024) compared to CON muscles at day 7 post-injury. At day 14 post-injury, CR-supplemented muscles generated higher absolute forces concomitant with greater contractile protein levels compared to CON (p = 0.001, p = 0.008) and WP-supplemented muscles (p = 0.003, p = 0.006). Creatine supplementation appears to offer an element of myoprotection which was not observed following whey protein supplementation. PMID:29710855

Potential role of viruses in white plague coral disease.

PubMed

Soffer, Nitzan; Brandt, Marilyn E; Correa, Adrienne M S; Smith, Tyler B; Thurber, Rebecca Vega

2014-02-01

White plague (WP)-like diseases of tropical corals are implicated in reef decline worldwide, although their etiological cause is generally unknown. Studies thus far have focused on bacterial or eukaryotic pathogens as the source of these diseases; no studies have examined the role of viruses. Using a combination of transmission electron microscopy (TEM) and 454 pyrosequencing, we compared 24 viral metagenomes generated from Montastraea annularis corals showing signs of WP-like disease and/or bleaching, control conspecific corals, and adjacent seawater. TEM was used for visual inspection of diseased coral tissue. No bacteria were visually identified within diseased coral tissues, but viral particles and sequence similarities to eukaryotic circular Rep-encoding single-stranded DNA viruses and their associated satellites (SCSDVs) were abundant in WP diseased tissues. In contrast, sequence similarities to SCSDVs were not found in any healthy coral tissues, suggesting SCSDVs might have a role in WP disease. Furthermore, Herpesviridae gene signatures dominated healthy tissues, corroborating reports that herpes-like viruses infect all corals. Nucleocytoplasmic large DNA virus (NCLDV) sequences, similar to those recently identified in cultures of Symbiodinium (the algal symbionts of corals), were most common in bleached corals. This finding further implicates that these NCLDV viruses may have a role in bleaching, as suggested in previous studies. This study determined that a specific group of viruses is associated with diseased Caribbean corals and highlights the potential for viral disease in regional coral reef decline.

A Global Transnational Sunni Caliphate: Realistic or Utopian Vision?

DTIC Science & Technology

2009-04-01

sovereignty and power, and are the completion of the Bible and Torah. The Quran is God’s divine word to man on how to conduct himself in this life in...conferences/WP886/ pdfs /WP886. pdf , (accessed on 3 April 2009). 16 Notes 49 Julia Voelker McQuaid reporting on Jakarata Caliphate conference observed...http://www.wiltonpark.org.uk/documents/conferences/WP886/ pdfs /WP886. pdf (accessed on 3 April 2009), p. 5. 50 Ibid, p. 20. 51 Ibid, p. 20. 17

Within-prison drug injection among HIV-infected male prisoners in Indonesia: a highly constrained choice.

PubMed

Culbert, Gabriel J; Waluyo, Agung; Iriyanti, Mariska; Muchransyah, Azalia P; Kamarulzaman, Adeeba; Altice, Frederick L

2015-04-01

In Indonesia, incarceration of people who inject drugs (PWID) and access to drugs in prison potentiate within-prison drug injection (WP-DI), a preventable and extremely high-risk behavior that may contribute substantially to HIV transmission in prison and communities to which prisoners are released. This mixed method study examined the prevalence, correlates, and social context of WP-DI among HIV-infected male prisoners in Indonesia. 102 randomly selected HIV-infected male prisoners completed semi-structured voice-recorded interviews about drug use changes after arrest, drug use cues within prison, and impact of WP-DI on HIV and addiction treatment. Logistic regression identified multivariate correlates of WP-DI and thematic analysis of interview transcripts used grounded-theory. Over half (56%) of participants reported previous WP-DI. Of those, 93% shared injection equipment in prison, and 78.6% estimated sharing needles with ≥ 10 other prisoners. Multivariate analyses independently correlated WP-DI with being incarcerated for drug offenses (AOR = 3.29, 95%CI = 1.30-8.31, p = 0.011) and daily drug injection before arrest (AOR = 5.23, 95%CI = 1.42-19.25, p = 0.013). Drug availability and proximity to drug users while incarcerated were associated with frequent drug craving and escalating drug use risk behaviors after arrest. Energetic heroin marketing and stigmatizing attitudes toward methadone contribute to WP-DI and impede addiction and HIV treatment. Frequent WP-DI and needle sharing among these HIV-infected Indonesian prison inmates indicate the need for structural interventions that reduce overcrowding, drug supply, and needle sharing, and improve detection and treatment of substance use disorders upon incarceration to minimize WP-DI and associated harm. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Within-Prison Drug Injection among HIV-infected Male Prisoners in Indonesia: A Highly Constrained Choice

PubMed Central

Culbert, Gabriel J.; Waluyo, Agung; Iriyanti, Mariska; Muchransyah, Azalia P.; Kamarulzaman, Adeeba; Altice, Frederick L.

2016-01-01

Background In Indonesia, incarceration of people who inject drugs (PWID) and access to drugs in prison potentiate within-prison drug injection (WP-DI), a preventable and extremely high-risk behavior that may contribute substantially to HIV transmission in prison and communities to which prisoners are released. Aims This mixed method study examined the prevalence, correlates, and social context of WP-DI among HIV-infected male prisoners in Indonesia. Methods 102 randomly selected HIV-infected male prisoners completed semi-structured voice-recorded interviews about drug use changes after arrest, drug use cues within prison, and impact of WP-DI on HIV and addiction treatment. Logistic regression identified multivariate correlates of WP-DI and thematic analysis of interview transcripts used grounded-theory. Results Over half (56%) of participants reported previous WP-DI. Of those, 93% shared injection equipment in prison, and 78.6% estimated sharing needles with ≥10 other prisoners. Multivariate analyses independently correlated WP-DI with being incarcerated for drug offenses (AOR=3.29, 95%CI=1.30–8.31, p=0.011) and daily drug injection before arrest (AOR=5.23, 95%CI=1.42–19.25, p=0.013). Drug availability and proximity to drug users while incarcerated were associated with frequent drug craving and escalating drug use risk behaviors after arrest. Energetic heroin marketing and stigmatizing attitudes toward methadone contribute to WP-DI and impede addiction and HIV treatment. Conclusions Frequent WP-DI and needle sharing among these HIV-infected Indonesian prison inmates indicate the need for structural interventions that reduce overcrowding, drug supply, and needle sharing, and improve detection and treatment of substance use disorders upon incarceration to minimize WP-DI and associated harm. PMID:25659895

Droop Control of Solar PV, Grid and Critical Load using Suppressing DC Current Injection Technique without Battery Storage

NASA Astrophysics Data System (ADS)

Dama Mr., Jayachandra; (Mrs. , Lini Mathew, Dr.; Srikanth Mr., G.

2017-08-01

This paper presents design of a sustainable solar Photo voltaic system for an Indian cities based residential/community house, integrated with grid, supporting it as supplementary sources, to meet energy demand of domestic loads. The role of renewable energy sources in Distributed Generation (DG) is increasingly being recognized as a supplement and an alternative to large conventional central power supply. Though centralized economic system that solely depends on cities is hampered due to energy deficiency, the use of solar energy in cities is never been tried widely due to technical inconvenience and high installation cost. To mitigate these problems, this paper proposes an optimized design of grid-tied PV system without storage which is suitable for Indian origin as it requires less installallation cost and supplies residential loads when the grid power is unavailable. The energy requirement is mainly fulfilled from PV energy module for critical load of a city located residential house and supplemented by grid/DG for base and peak load. The system has been developed for maximum daily household demand of 50kWp and can be scaled to any higher value as per requirement of individual/community building ranging from 50kWp to 60kWp as per the requirement. A simplified control system model has been developed to optimize and control flow of power from these sources. The simulation work, using MATLAB Simulink software for proposed energy management, has resulted in an optimal yield leading efficient power flow control of proposed system.

Teaching WP and DP with CP/M-Based Microcomputers.

ERIC Educational Resources Information Center

Bartholome, Lloyd W.

1982-01-01

The use of CP/M (Control Program Monitor)-based microcomputers in teaching word processing and data processing is explored. The system's advantages, variations, dictionary software, and future are all discussed. (CT)

Water Processor and Oxygen Generation Assembly

NASA Technical Reports Server (NTRS)

Bedard, John

1997-01-01

This report documents the results of the tasks which initiated efforts on design issues relating to the Water Processor (WP) and the Oxygen Generation Assembly (OGA) Flight Hardware for the International Space Station. This report fulfills the Statement of Work deliverables requirement for contract H-29387D. The following lists the tasks required by contract H-29387D: (1) HSSSI shall coordinate a detailed review of WP/OGA Flight Hardware program requirements with personnel from MSFC to identify requirements that can be eliminated without affecting the technical integrity of the WP/OGA Hardware; (2) HSSSI shall conduct the technical interchanges with personnel from MSFC to resolve design issues related to WP/OGA Flight Hardware; (3) HSSSI will initiate discussions with Zellwegger Analytics, Inc. to address design issues related to WP and PCWQM interfaces.

Determinants of Work Performance in Workers with Depression and Anxiety: A Cross-Sectional Study.

PubMed

Ivandic, Ivana; Kamenov, Kaloyan; Rojas, Diego; Cerón, Gloria; Nowak, Dennis; Sabariego, Carla

2017-04-26

Depression and anxiety are highly prevalent disorders with an impact on existential aspects of person's life, including employment i.e., work performance (WP). In order to develop appropriate strategies, it is essential to identify determinants of WP. The objective of this study was to identify the built, social, attitudinal and health system-related environmental determinants of WP in workers with anxiety or depression in total ( N = 1211) and regarding the level of disability. Hierarchical binary logistic regression was performed on data obtained from implementation of the WHO Model Disability Survey (MDS) in Chile in 2015. Hindering aspects of means of transportation and workplace, and the use of personal assistance were determinants of WP for all workers with anxiety or depression. Results differed with level of disability. Hindering aspects of means of transportation and workplace, and discrimination were determinants of WP for persons with mild to moderate disability, while hindering aspects of the workplace and dwelling, and the use of personal assistance were determinants of WP for persons with severe disability. Our results emphasize the need for a broader understanding of determinants of WP and the requirement for an integrative approach in developing both universal and specific strategies that go beyond workplace settings.

Determinants of Work Performance in Workers with Depression and Anxiety: A Cross-Sectional Study

PubMed Central

Ivandic, Ivana; Kamenov, Kaloyan; Rojas, Diego; Cerón, Gloria; Nowak, Dennis; Sabariego, Carla

2017-01-01

Depression and anxiety are highly prevalent disorders with an impact on existential aspects of person’s life, including employment i.e., work performance (WP). In order to develop appropriate strategies, it is essential to identify determinants of WP. The objective of this study was to identify the built, social, attitudinal and health system-related environmental determinants of WP in workers with anxiety or depression in total (N = 1211) and regarding the level of disability. Hierarchical binary logistic regression was performed on data obtained from implementation of the WHO Model Disability Survey (MDS) in Chile in 2015. Hindering aspects of means of transportation and workplace, and the use of personal assistance were determinants of WP for all workers with anxiety or depression. Results differed with level of disability. Hindering aspects of means of transportation and workplace, and discrimination were determinants of WP for persons with mild to moderate disability, while hindering aspects of the workplace and dwelling, and the use of personal assistance were determinants of WP for persons with severe disability. Our results emphasize the need for a broader understanding of determinants of WP and the requirement for an integrative approach in developing both universal and specific strategies that go beyond workplace settings. PMID:28445433

Pro-apoptotic activity of new analog of anthracyclines--WP 631 in advanced ovarian cancer cell line.

PubMed

Gajek, Arkadiusz; Denel, Marta; Bukowska, Barbara; Rogalska, Aneta; Marczak, Agnieszka

2014-03-01

In this work we investigated the mode of cell death induced by WP 631, a novel anthracycline antibiotic, in the ovarian cancer cell line (OV-90) derived from the malignant ascites of a patient diagnosed with advanced disease. The effects were compared with those of doxorubicin (DOX), a first generation anthracycline. The ability of WP 631 to induce apoptosis and necrosis was examined by double staining with Annexin V and propidium iodide, measurements of the level of intracellular calcium ions and cytochrome c, PARP cleavage. We also investigated the possible involvement of the caspases activation, DNA degradation (comet assay) and intracellular reactive oxygen species (ROS) production in the development of the apoptotic events and their significance for drug efficiency. The results obtained clearly demonstrate that antiproliferative capacity of WP 631 in tested cell line was a few times greater than that of DOX. Furthermore, ovarian cancer cells treated with WP 631 showed a higher mean level of basal DNA damage in comparison to DOX. In conclusion, WP 631 is able to induce caspase - dependent apoptosis in human ovarian cancer cells. Obtained results suggested that WP 631 may be a candidate for further evaluation as chemotherapeutic agents for human cancers. Copyright © 2013 Elsevier Ltd. All rights reserved.

Thermal Performance Analysis of a Geologic Borehole Repository

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reagin, Lauren

2016-08-16

The Brazilian Nuclear Research Institute (IPEN) proposed a design for the disposal of Disused Sealed Radioactive Sources (DSRS) based on the IAEA Borehole Disposal of Sealed Radioactive Sources (BOSS) design that would allow the entirety of Brazil’s inventory of DSRS to be disposed in a single borehole. The proposed IPEN design allows for 170 waste packages (WPs) containing DSRS (such as Co-60 and Cs-137) to be stacked on top of each other inside the borehole. The primary objective of this work was to evaluate the thermal performance of a conservative approach to the IPEN proposal with the equivalent of twomore » WPs and two different inside configurations using Co-60 as the radioactive heat source. The current WP configuration (heterogeneous) for the IPEN proposal has 60% of the WP volume being occupied by a nuclear radioactive heat source and the remaining 40% as vacant space. The second configuration (homogeneous) considered for this project was a homogeneous case where 100% of the WP volume was occupied by a nuclear radioactive heat source. The computational models for the thermal analyses of the WP configurations with the Co-60 heat source considered three different cooling mechanisms (conduction, radiation, and convection) and the effect of mesh size on the results from the thermal analysis. The results of the analyses yielded maximum temperatures inside the WPs for both of the WP configurations and various mesh sizes. The heterogeneous WP considered the cooling mechanisms of conduction, convection, and radiation. The temperature results from the heterogeneous WP analysis suggest that the model is cooled predominantly by conduction with effect of radiation and natural convection on cooling being negligible. From the thermal analysis comparing the two WP configurations, the results suggest that either WP configuration could be used for the design. The mesh sensitivity results verify the meshes used, and results obtained from the thermal analyses were close to being independent of mesh size. The results from the computational case and analytically-calculated case for the homogeneous WP in benchmarking were almost identical, which indicates that the computational approach used here was successfully verified by the analytical solution.« less

WASTE PACKAGE REMEDIATION SYSTEM DESCRIPTION DOCUMENT

DOE Office of Scientific and Technical Information (OSTI.GOV)

N.D. Sudan

2000-06-22

The Waste Package Remediation System remediates waste packages (WPs) and disposal containers (DCs) in one of two ways: preparation of rejected DC closure welds for repair or opening of the DC/WP. DCs are brought to the Waste Package Remediation System for preparation of rejected closure welds if testing of the closure weld by the Disposal Container Handling System indicates an unacceptable, but repairable, welding flaw. DC preparation of rejected closure welds will require removal of the weld in such a way that the Disposal Container Handling System may resume and complete the closure welding process. DCs/WPs are brought to themore » Waste Package Remediation System for opening if the Disposal Container Handling System testing of the DC closure weld indicates an unrepairable welding flaw, or if a WP is recovered from the subsurface repository because suspected damage to the WP or failure of the WP has occurred. DC/WP opening will require cutting of the DC/WP such that a temporary seal may be installed and the waste inside the DC/WP removed by another system. The system operates in a Waste Package Remediation System hot cell located in the Waste Handling Building that has direct access to the Disposal Container Handling System. One DC/WP at a time can be handled in the hot cell. The DC/WP arrives on a transfer cart, is positioned within the cell for system operations, and exits the cell without being removed from the cart. The system includes a wide variety of remotely operated components including a manipulator with hoist and/or jib crane, viewing systems, machine tools for opening WPs, and equipment used to perform pressure and gas composition sampling. Remotely operated equipment is designed to facilitate DC/WP decontamination and hot cell equipment maintenance, and interchangeable components are provided where appropriate. The Waste Package Remediation System interfaces with the Disposal Container Handling System for the receipt and transport of WPs and DCs. The Waste Handling Building System houses the system, and provides the facility, safety, and auxiliary systems required to support operations. The system receives power from the Waste Handling Building Electrical System. The system also interfaces with the various DC systems.« less

East Asian winter temperature variation associated with the combined effects of AO and WP pattern

NASA Astrophysics Data System (ADS)

Park, Hye-Jin; Ahn, Joong-Bae

2016-04-01

The combined effects of the Arctic Oscillation (AO) and Western Pacific (WP) teleconnection pattern on the East Asian winter monsoon (EAWM) over the last 56 years (1958/59-2013/2014) were investigated using NCEP/NCAR reanalysis data (Park and Ahn, 2015). The study results revealed that the effect of the AO on winter temperature in East Asia could be changed depending on the phases of the WP pattern in the North Pacific. The negative relationship between the EAWM and the AO increased when the AO and WP were in-phase with each other. Hence, when winter negative (positive) AO was accompanied by negative (positive) WP, negative (positive) temperature anomalies were dominant across the entire East Asia region. Conversely, when the AO and WP were of-of-phase, the winter temperature anomaly in East Asia did not show distinct changes. Furthermore, from the perspective of stationary planetary waves, the zonal wavenumber-2 patterns of sea level pressure and geopotential height at 500hPa circulation strengthened when the AO and WP were in-phase but were not significant for the out-of-phase condition. It explained the possible mechanism of the combined effects of the AO and WP on the circulation related to EAWM. Reference Park, H.-J., and J.-B. Ahn (2015) Combined effect of the Arctic Oscillation and the Western Pacific pattern on East Asia winter temperature, Clim. Dyn. DOI:10.1007/s00382-015-2763-2. Acknowledgements This work was funded by the Korea Meteorological Administration Research and Development Program under grant KMIPA2015-2081.

ETV REPORT: REMOVAL OF CHEMICAL CONTAMINANTS IN DRINKING WATER – WATTS PREMIER INC. WP-4V DRINKING WATER TREATMENT SYSTEM

EPA Science Inventory

The Watts Premier WP-4V POU drinking water treatment system was tested for removal of aldicarb, benzene, cadmium, carbofuran, cesium, chloroform, dichlorvos, dicrotophos, fenamiphos, mercury, mevinphos, oxamyl, strontium, and strychnine. The WP-4V employs a reverse osmosis (RO) m...

Is Word-Problem Solving a Form of Text Comprehension?

ERIC Educational Resources Information Center

Fuchs, Lynn S.; Fuchs, Douglas; Compton, Donald L.; Hamlett, Carol L.; Wang, Amber Y.

2015-01-01

This study's hypotheses were that (a) word-problem (WP) solving is a form of text comprehension that involves language comprehension processes, working memory, and reasoning, but (b) WP solving differs from other forms of text comprehension by requiring WP-specific language comprehension as well as general language comprehension. At the start of…

Crystal structure and functional characterization of yeast YLR011wp, an enzyme with NAD(P)H-FMN and ferric iron reductase activities.

PubMed

Liger, Dominique; Graille, Marc; Zhou, Cong-Zhao; Leulliot, Nicolas; Quevillon-Cheruel, Sophie; Blondeau, Karine; Janin, Joël; van Tilbeurgh, Herman

2004-08-13

Flavodoxins are involved in a variety of electron transfer reactions that are essential for life. Although FMN-binding proteins are well characterized in prokaryotic organisms, information is scarce for eukaryotic flavodoxins. We describe the 2.0-A resolution crystal structure of the Saccharomyces cerevisiae YLR011w gene product, a predicted flavoprotein. YLR011wp indeed adopts a flavodoxin fold, binds the FMN cofactor, and self-associates as a homodimer. Despite the absence of the flavodoxin key fingerprint motif involved in FMN binding, YLR011wp binds this cofactor in a manner very analogous to classical flavodoxins. YLR011wp closest structural homologue is the homodimeric Bacillus subtilis Yhda protein (25% sequence identity) whose homodimer perfectly superimposes onto the YLR011wp one. Yhda, whose function is not documented, has 53% sequence identity with the Bacillus sp. OY1-2 azoreductase. We show that YLR011wp has an NAD(P)H-dependent FMN reductase and a strong ferricyanide reductase activity. We further demonstrate a weak but specific reductive activity on azo dyes and nitrocompounds.

Dual photo- and pH-responsive supramolecular nanocarriers based on water-soluble pillar[6]arene and different azobenzene derivatives for intracellular anticancer drug delivery.

PubMed

Hu, Xiao-Yu; Jia, Keke; Cao, Yu; Li, Yan; Qin, Shan; Zhou, Fan; Lin, Chen; Zhang, Dongmei; Wang, Leyong

2015-01-12

Two novel types of supramolecular nanocarriers fabricated by the amphiphilic host-guest inclusion complex formed from water-soluble pillar[6]arene (WP6) and azobenzene derivatives G1 or G2 have been developed, in which G1 is structurally similar to G2 but has an extra phenoxy group in its hydrophobic region. Supramolecular micelles can be initially formed by WP6 with G1, which gradually transform into layered structures with liquid-crystalline properties, whereas stable supramolecular vesicles are obtained from WP6 and G2, which exhibit dual photo- and pH-responsiveness. Notably, the resulting WP6⊃G2 vesicles can efficiently encapsulate anticancer drug mitoxantrone (MTZ) to achieve MTZ-loaded vesicles, which maintain good stability in a simulated normal physiological environment, whereas in an acid environment similar to that of tumor cells or with external UV irradiation, the encapsulated drug is promptly released. More importantly, cytotoxicity assay indicates that such vesicles have good biocompatibility and the MTZ-loaded vesicles exhibit comparable anticancer activity to free MTZ, especially with additional UV stimulus, whereas its cytotoxicity for normal cells was remarkably reduced. Flow cytometric analysis further confirms that the cancer cell death caused by MTZ-loaded vesicles is associated with apoptosis. Therefore, the dual pH- and UV-responsive supramolecular vesicles are a potential platform for controlled release and targeted anticancer drug delivery. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Effects of Whey Protein Supplementation Associated With Resistance Training on Muscular Strength, Hypertrophy, and Muscle Quality in Preconditioned Older Women.

PubMed

Sugihara Junior, Paulo; Ribeiro, Alex S; Nabuco, Hellen C G; Fernandes, Rodrigo R; Tomeleri, Crisieli M; Cunha, Paolo M; Venturini, Danielle; Barbosa, Décio S; Schoenfeld, Brad J; Cyrino, Edilson S

2018-06-22

The purpose of this study was to investigate the effect of whey protein (WP) supplementation on muscular strength, hypertrophy, and muscular quality in older women preconditioned to resistance training (RT). In a randomized, double-blind, and placebo (PLA)-controlled design, 31 older women (67.4 ± 4.0 years, 62.0 ± 6.9 kg, 155.9 ± 5.7 cm, and 25.5 ± 2.4 kg/m 2 ) received either 35 g of WP (n = 15) or 35 g of PLA (n = 16) over a 12-week study period while performing an RT program three times a week. Dietary intake, one-repetition maximum test, and skeletal muscle mass by dual-energy X-ray absorptiometry were assessed before and after the intervention period. Both groups showed significant (p < .05) improvements in skeletal muscle mass and total strength, and the WP group realized greater increases (p < .05) in these measures compared with PLA (skeletal muscle mass: WP = +4.8% vs. PLA = +2.3%; strength: WP = +8.7% vs. PLA = +4.9%). Muscular quality increased (p < .05) in both groups (WP = +2.9% vs. PLA = +1.5%) without statistical differences (p > .05) noted between conditions. We conclude that WP supplementation in combination with RT induces higher increases in both strength and hypertrophy in older women preconditioned to RT.

A small molecule deubiquitinase inhibitor increases localization of inducible nitric oxide synthase to the macrophage phagosome and enhances bacterial killing.

PubMed

Burkholder, Kristin M; Perry, Jeffrey W; Wobus, Christiane E; Donato, Nicholas J; Showalter, Hollis D; Kapuria, Vaibhav; O'Riordan, Mary X D

2011-12-01

Macrophages are key mediators of antimicrobial defense and innate immunity. Innate intracellular defense mechanisms can be rapidly regulated at the posttranslational level by the coordinated addition and removal of ubiquitin by ubiquitin ligases and deubiquitinases (DUBs). While ubiquitin ligases have been extensively studied, the contribution of DUBs to macrophage innate immune function is incompletely defined. We therefore employed a small molecule DUB inhibitor, WP1130, to probe the role of DUBs in the macrophage response to bacterial infection. Treatment of activated bone marrow-derived macrophages (BMM) with WP1130 significantly augmented killing of the intracellular bacterial pathogen Listeria monocytogenes. WP1130 also induced killing of phagosome-restricted bacteria, implicating a bactericidal mechanism associated with the phagosome, such as the inducible nitric oxide synthase (iNOS). WP1130 had a minimal antimicrobial effect in macrophages lacking iNOS, indicating that iNOS is an effector mechanism for WP1130-mediated bacterial killing. Although overall iNOS levels were not notably different, we found that WP1130 significantly increased colocalization of iNOS with the Listeria-containing phagosome during infection. Taken together, our data indicate that the deubiquitinase inhibitor WP1130 increases bacterial killing in macrophages by enhancing iNOS localization to the phagosome and suggest a potential role for ubiquitin regulation in iNOS trafficking.

RpA, an extracellular protease similar to the metalloprotease of serralysin family, is required for pathogenicity of Ralstonia pickettii.

PubMed

Chen, C-M; Liu, J-J; Chou, C-W; Lai, C-H; Wu, L-T

2015-10-01

To investigate the biochemical and functional properties of an extracellular protease, RpA, in Ralstonia pickettii WP1 isolated from water supply systems. An extracellular protease was identified and characterized from R. pickettii WP1. A mutant strain WP1M2 was created from strain WP1 by mini-Tn5 transposition. The culture filtrates from WP1M2 had a lower cytotoxic effect than the parental WP1 on several mammalian cell lines. Cloning and sequence analysis revealed the Tn5 transposon inserted at a protease gene (rpA) which is 81% homologous to prtA and aprX genes of Pseudomonas fluorescens. The rpA gene encodes a 482-residue protein showing sequence similarity to metalloproteases of the serralysin family. The RpA protein was expressed in Escherichia coli using a pET expression vector and purified as a 55 kDa molecular weight protein. Furthermore, the protease activity of RpA was inhibited by protease inhibitor and heat treatment. The in vitro cytotoxic activity of R. pickettii culture filtrates was attributed to RpA protease. An extracellular protease, RpA, was identified from R. pickettii WP1 isolated from water supply system. The RpA metalloproteases is required for the pathogenicity of R. pickettii to mammalian cell lines. © 2015 The Society for Applied Microbiology.

Resistance and behavioural response of Plutella xylostella (Lepidoptera: Plutellidae) populations to Bacillus thuringiensis formulations.

PubMed

Zago, Hugo B; Siqueira, Herbert Á A; Pereira, Eliseu J G; Picanço, Marcelo C; Barros, Reginaldo

2014-03-01

Insecticide resistance is probably the major cause of control failure of Plutella xylostella (L.) in Brazil. In most production regions, the use of chemicals has been the prevalent method of control, with reduced efficacy through cropping seasons, even for the most recent use of products based on Bacillus thuringiensis (Bt). The current status of the resistance to these products was assessed, as well as the behavioural response of P. xylostella populations to Bt sprays. Most populations of P. xylostella were resistant to Bt products, particularly to Xentari®WDG (2-54-fold). Differences in walking characteristics of larvae were variable for most populations, for both Dipel®WP and Xentari®WDG, but not associated with resistance. Most females preferred to lay eggs on untreated surfaces and showed a reduced proportion of oviposition on treated surfaces that only correlated with resistance to Dipel®WP (r = -0.74, P = 0.02). Broad and indiscriminate use of Bt-based products has selected Brazilian P. xylostella populations to resistance. Larval movement appears to be a resistance-independent mechanism. Most populations of P. xylostella preferred to lay eggs on Bt-free surfaces, which might be a result of growers' practice of spraying the cabbage head. Reduced oviposition on treated surfaces correlated with physiological resistance, suggesting a behavioural response among the Bt-resistant colonies to Dipel®WP. © 2013 Society of Chemical Industry.

Potent in vivo antifungal activity against powdery mildews of pregnane glycosides from the roots of Cynanchum wilfordii.

PubMed

Yoon, Mi-Young; Choi, Nam Hee; Min, Byung Sun; Choi, Gyung Ja; Choi, Yong Ho; Jang, Kyoung Soo; Han, Seong-Sook; Cha, Byeongjin; Kim, Jin-Cheol

2011-11-23

Two new pregnane glycosides, kidjoranine 3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 4)-α-L-cymaropyranosyl-(1 → 4)-β-D-cymaropyranosyl-(1→4)-α-L-diginopyranosyl-(1 → 4)-β-D-cymaropyranoside (5) and caudatin 3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 4)-α-L-cymaropyranosyl-(1 → 4)-β-D-cymaropyranosyl-(1 → 4)-α-L-diginopyranosyl-(1 → 4)-β-D-cymaropyranoside (6), were isolated from the roots of Cynanchum wilfordii along with four known compounds (1-4). The antifungal activities of the six compounds against barley powdery mildew caused by Blumeria graminis f. sp. hordei were compared to the antifungal activity of polyoxin B. The caudatin glycosides (1, 4, and 6) showed stronger antifungal activities than polyoxin B, whereas kidjoranine glycosides (2, 3, and 5) had weaker activities than polyoxin B. A wettable powder-type formulation (C. wilfordii-WP20) of the ethyl acetate extract from C. wilfordii roots prohibited the development of barley powdery mildew much more effectively than the commercial fungicide polyoxin B-WP10. In addition, C. wilfordii-WP20 effectively controlled strawberry powdery mildew caused by Sphaerotheca humuli under greenhouse conditions. Thus, the crude extract containing the pregnane glycosides can be used as a botanical fungicide for the environmentally benign control of powdery mildews.

Phylogenetic analysis of Archaea in the deep-sea sediments of west Pacific Warm Pool.

PubMed

Wang, Peng; Xiao, Xiang; Wang, Fengping

2005-06-01

Archaea are known to play important roles in carbon cycling in marine sediments. The main compositions of archaeal community in five deep-sea sediment samples collected from west Pacific Warm Pool area (WP-0, WP-1, WP-2, WP-3, WP-4), and in five sediment layers (1 cm-, 3 cm-, 6 cm-, 10 cm-, 12 cm- layer) of the 12 cm sediment core of WP-0 were checked and compared by denaturing gradient gel electrophoresis and 16 S rRNA gene sequencing. It was revealed that all the deep-sea sediment samples checked contained members of non-thermophilic marine group I crenarchaeota as the predominant archaeal group. To further detect groups of archaea possibly relating with C1 metabolism, PCR amplification was carried out using primers targeting methane-oxidizing archaea. Although no methane-oxidizing archaea was detected, a group of novel archaea (named as WPA) was instead identified from all these five WP samples by clone analysis. They could be placed in the euryarchaeota kingdom, separated into two distinct groups, the main group was peripherally related with methanogens, the other group related with Thermoplasma. The vertical distributions of WPA, archaea and bacteria along the WP-0 sediment column were determined by quantitative-PCR. It was found that bacteria dominated at all depths, the numbers of bacteria were 10-10(4) times more than those of archaea. The proportion of archaea versus bacteria had a depth related increasing tendency, it was lowest at the first layer (0.01%), reached highest at the 12 cm- layer (10%). WPA only constituted a small proportion of the archaeal community (0.05% to 5%) of west Pacific Warm Pool sediment.

Limiting prolonged inflammation during proliferation and remodeling phases of wound healing in streptozotocin-induced diabetic rats supplemented with camel undenatured whey protein.

PubMed

Ebaid, Hossam; Ahmed, Osama M; Mahmoud, Ayman M; Ahmed, Rasha R

2013-07-25

Impaired diabetic wound healing occurs as a consequence of excessive reactive oxygen species (ROS) and inflammatory cytokine production. We previously found that whey protein (WP) was able to normally regulate the ROS and inflammatory cytokines during the inflammatory phase (first day) in streptozotocin (STZ)-diabetic wound healing. This study was designed to assess the effect of WP on metabolic status, the inflammation and anti-inflammation response, oxidative stress and the antioxidant defense system during different phases of the wound healing process in diabetic rats. WP at a dosage of 100 mg/kg of body weight, dissolved in 1% CMC, was orally administered daily to wounded normal (non-diabetic) and STZ-induced diabetic rats for 8 days starting from the 1st day after wounding. The data revealed that WP enhanced wound closure and was associated with an increase in serum insulin levels in diabetic rats and an alleviation of hyperglycemic and hyperlipidemic states in diabetic animals. The increase in insulin levels as a result of WP administration is associated with a marked multiplication of β-cells in the core of islets of Langerhans. WP induced a reduction in serum TNF-α, IL-1β and IL-6 levels and an increase in IL-10 levels, especially on the 4th day after wounding and treatment. WP also suppressed hepatic lipid peroxidation and stimulated the antioxidant defense system by increasing the level of glutathione and the activity of glutathione-S-transferase, glutathione peroxidase and superoxide dismutase (SOD) in wounded diabetic rats. WP was observed to enhance wound closure by improving the diabetic condition, limiting prolonged inflammation, suppressing oxidative stress and elevating the antioxidant defense system in diabetic rats.

Widespread pain following whiplash-associated disorders: incidence, course, and risk factors.

PubMed

Holm, Lena W; Carroll, Linda J; Cassidy, J David; Skillgate, Eva; Ahlbom, Anders

2007-01-01

To investigate the incidence and course of widespread pain (WP) subsequent to localized pain in subjects with whiplash-associated disorders (WAD); and to investigate the influence of depressive symptoms, neck pain intensity, number of whiplash-associated symptoms, and number of painful body areas on such conditions. From a large prospective cohort of injury claimants who reported WAD after motor vehicle collision (MVC; n = 7462), we identified a subgroup with only localized head/neck/back pain, and who responded to one or more followup questionnaires mailed at 6 weeks and 4, 6, and 12 months after the MVC (n = 266). Pain drawings were distributed at the followup, and we defined WP as having 9 or more painful areas, including posterior neck, at any of these occasions. Depressive symptoms were assessed with the Center for Epidemiological Studies Depression Scale and pain intensity with on a visual analog scale (VAS). The cumulative incidence of WP was 21%, and it occurred early after the injury. Continuous WP over the 12 months was rare. The odds for developing WP were greater in those with depressive symptoms (OR 3.2, 95% CI 1.6-6.3), VAS pain intensity 55-100 (OR 3.2, 95% CI 1.3-8.0), reporting > or = 3 pain-associated symptoms (OR 1.9, 95% CI 0.9-3.8), and those reporting 4 or 5 painful body areas (OR 2.6, 95% CI 1.3-5.4). WP occurred early in the course. Even though the cumulative incidence was 21%, continuous WP was rare. Subjects with WAD who report early depressive symptoms and more severe neck injury symptoms are at risk of developing WP after MVC.

Limiting prolonged inflammation during proliferation and remodeling phases of wound healing in streptozotocin-induced diabetic rats supplemented with camel undenatured whey protein

PubMed Central

2013-01-01

Background Impaired diabetic wound healing occurs as a consequence of excessive reactive oxygen species (ROS) and inflammatory cytokine production. We previously found that whey protein (WP) was able to normally regulate the ROS and inflammatory cytokines during the inflammatory phase (first day) in streptozotocin (STZ)-diabetic wound healing. This study was designed to assess the effect of WP on metabolic status, the inflammation and anti-inflammation response, oxidative stress and the antioxidant defense system during different phases of the wound healing process in diabetic rats. WP at a dosage of 100 mg/kg of body weight, dissolved in 1% CMC, was orally administered daily to wounded normal (non-diabetic) and STZ-induced diabetic rats for 8 days starting from the 1st day after wounding. Results The data revealed that WP enhanced wound closure and was associated with an increase in serum insulin levels in diabetic rats and an alleviation of hyperglycemic and hyperlipidemic states in diabetic animals. The increase in insulin levels as a result of WP administration is associated with a marked multiplication of β-cells in the core of islets of Langerhans. WP induced a reduction in serum TNF-α, IL-1β and IL-6 levels and an increase in IL-10 levels, especially on the 4th day after wounding and treatment. WP also suppressed hepatic lipid peroxidation and stimulated the antioxidant defense system by increasing the level of glutathione and the activity of glutathione-S-transferase, glutathione peroxidase and superoxide dismutase (SOD) in wounded diabetic rats. Conclusions WP was observed to enhance wound closure by improving the diabetic condition, limiting prolonged inflammation, suppressing oxidative stress and elevating the antioxidant defense system in diabetic rats. PMID:23883360

Determination of the water retention of peat soils in the range of the permanent wilting point.

NASA Astrophysics Data System (ADS)

Nünning, Lena; Bechtold, Michel; Dettmann, Ullrich; Piayda, Arndt; Tiemeyer, Bärbel; Durner, Wolfgang

2017-04-01

Global coverage of peatlands decreases due to the use of peat for horticulture and to the drainage of peatlands for agriculture and forestry. While alternatives for peat in horticulture exist, profitable agriculture on peatlands and climate protection are far more difficult to combine. A controlled water management that is optimized to stabilize yields while reducing peat degradation provides a promising path in this direction. For this goal, profound knowledge of hydraulic properties of organic soil is essential, for which, however, literature is scarce. This study aimed to compare different methods to determine the water retention of organic soils in the dry range (pF 3 to 4.5). Three common methods were compared: two pressure based apparatus (ceramic plate vs. membrane, Eijkelkamp) and a dew point potentiameter (WP4C, Decagon Devices), which is based on the equilibrium of soil water potential and air humidity. Two different types of organic soil samples were analyzed: i) samples wet from the field and ii) samples that were rewetted after oven-drying. Additional WP4C measurements were performed at samples from standard evaporation experiments directly after they have been finished. Results were: 1) no systematic differences between pressure apparatus and WP4C measurements, 2) however, high moisture variability of the samples from the pressure apparatus as well as high variability of the WP4C measurements at these samples when they were removed from these devices which indicated that applied pressure did not establish well in all samples, 3) rewetted oven-dried samples resulted in up to three times lower soil moistures even after long equilibrium times, i.e. there was a strong and long-lasting hysteresis effect that was highest for less degraded peat samples, 4) and highly consistent WP4C measurements at samples from the end of the evaporation experiment. Results provide useful information for deriving reliable water retention characteristics for organic soils.

Stable Weyl points, trivial surface states, and particle-hole compensation in WP2

NASA Astrophysics Data System (ADS)

Razzoli, E.; Zwartsenberg, B.; Michiardi, M.; Boschini, F.; Day, R. P.; Elfimov, I. S.; Denlinger, J. D.; Süss, V.; Felser, C.; Damascelli, A.

2018-05-01

A possible connection between extremely large magnetoresistance and the presence of Weyl points has garnered much attention in the study of topological semimetals. Exploration of these concepts in transition-metal diphosphides WP2 has been complicated by conflicting experimental reports. Here we combine angle-resolved photoemission spectroscopy (ARPES) and density functional theory (DFT) calculations to disentangle surface and bulk contributions to the ARPES intensity, the superposition of which has plagued the determination of the band structure in WP2. Our results show that while the hole- and electronlike Fermi surface sheets originating from surface states have different areas, the bulk-band structure of WP2 is electron-hole compensated in agreement with DFT. Furthermore, the ARPES band structure is compatible with the presence of at least four temperature-independent Weyl points, confirming the topological nature of WP2 and its stability against lattice distortions.

Michigan/Air Force Research Laboratory (AFRL) Collaborative Center in Control Science (MACCCS)

DTIC Science & Technology

2016-09-01

AFRL-RQ-WP-TR-2016-0139 MICHIGAN/AIR FORCE RESEARCH LABORATORY (AFRL) COLLABORATIVE CENTER IN CONTROL SCIENCE (MACCCS) Anouck Girard...Final 18 April 2007 – 30 September 2016 4. TITLE AND SUBTITLE MICHIGAN/AIR FORCE RESEARCH LABORATORY (AFRL) COLLABORATIVE CENTER IN CONTROL SCIENCE...and amplify an internationally recognized center of excellence in control science research and education, through interaction between the faculty and

Efficacy of a workplace-based weight loss program for overweight male shift workers: the Workplace POWER (Preventing Obesity Without Eating like a Rabbit) randomized controlled trial.

PubMed

Morgan, Philip J; Collins, Clare E; Plotnikoff, Ronald C; Cook, Alyce T; Berthon, Bronwyn; Mitchell, Simon; Callister, Robin

2011-05-01

To evaluate the feasibility and efficacy of a workplace-based weight loss program (Workplace POWER-WP) for male shift workers. A prospective, two-armed randomized controlled trial of 110 overweight/obese (BMI 25-40) (mean [SD] age = 44.4 [8.6] years; BMI = 30.5 [3.6]) male employees at Tomago Aluminium aged 18-65. In October (2009) men were randomized to either (i) WP program (n=65) or (ii) a 14-week wait-list control group (n=45). The 3-month program involved one information session, program booklets, group-based financial incentives and an online component. Men were assessed at baseline and at 14-week follow-up for weight (primary outcome), waist circumference, BMI, blood pressure, resting heart rate, self-reported physical activity and dietary variables, and physical activity and dietary cognitions. Intention-to-treat analysis using linear mixed models revealed significant between group differences for weight loss after 14 weeks (P < .001, Cohen's d = 0.34). Significant intervention effects were also found for waist circumference (P < .001, d = 0.63), BMI (P < .001, d = 0.41), systolic blood pressure (P = .02, d = 0.48), resting heart rate (P < .001, d = 0.81), physical activity (P = .03, d = 0.77), sweetened beverages (P < .02, d = 0.5-0.6) and physical activity-related cognitions (P < .02, d=0.6). The WP program was feasible and efficacious and resulted in significant weight loss and improved health-related outcomes and behaviours in overweight male shift workers. Copyright © 2011 Elsevier Inc. All rights reserved.

Vigilant Spirit Control Station (VSCS) - The Face of COUNTER

DTIC Science & Technology

2008-08-01

AFRL-RH-WP-TR-2012-0015 VIGILANT SPIRIT CONTROL STATION ( VSCS ) “THE FACE OF COUNTER” Gregory L. Feitshans, Allen J. Rowe, Jason E...From - To) 01-08-08 Interim 1 JUN 2006 – 1 JUN 2008 4. TITLE AND SUBTITLE VIGILANT SPIRIT CONTROL STATION ( VSCS ) “THE FACE OF COUNTER” 5a...7 4.0 VSCS USER INTERFACE PRIMARY COMPONENTS OVERVIEW

Genome Sequence of Thalassospira profundimaris Type Strain WP0211

PubMed Central

Lai, Qiliang

2012-01-01

Thalassospira profundimaris WP0211T was isolated from a pyrene-degrading consortium, enriched from deep-sea sediment collected from the West Pacific Ocean. Here, we present the draft genome of strain WP0211T, which contains 4,380,232 bp with a G+C content of 55.19% and contains 4,040 protein-coding genes and 45 tRNAs. PMID:23209215

Genome sequence of Thalassospira profundimaris type strain WP0211.

PubMed

Lai, Qiliang; Shao, Zongze

2012-12-01

Thalassospira profundimaris WP0211(T) was isolated from a pyrene-degrading consortium, enriched from deep-sea sediment collected from the West Pacific Ocean. Here, we present the draft genome of strain WP0211(T), which contains 4,380,232 bp with a G+C content of 55.19% and contains 4,040 protein-coding genes and 45 tRNAs.

Photometric Observations of the Near-Earth Asteroids (326683) 2002 WP and 2016 LX48

NASA Astrophysics Data System (ADS)

Sonka, Adrian Bruno; Popescu, Marcel; Nedelcu, Dan Alin; Gherase, Radu Mihai; Vass, Gheroghe

2017-07-01

We obtained photometric results for the near-Earth asteroids (326683) 2002 WP and 2016 LX48 during their close approaches in 2016 December and October, respectively. Our analysis found a synodic period for (326683) 2002 WP of P = 6.2772 ± 0.0479 h and, for 2016 LX48, P = 5.6742 ± 0.0074 h.

[Carbon footprint of wheat-summer direct-seeding peanut planting system in Shandong Pro-vince, China].

PubMed

Ziu, Xiao Xia; Zhang, Xiao Jun; Wang, Yue Fu; Wang, Ming Lun

2018-03-01

Clarifying the carbon emissions in wheat-summer direct-seeding peanut planting (W-P) system could help realize the synergistic effects of high yield and low carbon emissions. Based on whole life cycle method, we constructed a carbon footprint model to calculate the carbon emissions of W-P system. We found that the net income of W-P system was 71.2%-88.3% higher than that of wheat-maize rotation (W-M) system. The carbon emissions per unit area under W-P system was 6977.9-8018.5 kg·hm -2 , being 6.2% higher than that of W-M system. The carbon emission of per net income under W-P system was 0.23-0.28 kg CO 2 -eq·yuan -1 , which was 37.4%-44.1% lower than that of W-M system. Combining the net income and carbon emissions of per net income, W-P system could achieve synergistic effects of high yield and low carbon emissions, which would fulfill the targets of agricultural supply-side structural reform with optimizing supply, enhancing quality and efficiency, and increasing income of peasants.

Maximum value of the pulse energy of a passively Q-switched laser as a function of the pump power.

PubMed

Li, Jianlang; Ueda, Ken-ichi; Dong, Jun; Musha, Mitsuru; Shirakawa, Akira

2006-07-20

The finite recovery time Ts of the bleached absorber is presented as one of the possible mechanisms accounting for the increase-maximum-decrease in pulse energy E with the pumping rate Wp in cw-pumped passively Q-switched solid-state lasers, by analytically evaluating the sign of the derivative partial differentialE/ partial differentialWP. The results show that, in the low pump regime (T>Ts, T is the interpulse period), the initial population density ni remains constant, the final population density nf decreases with Wp, and this results in a monotonic increase of E with Wp. In the high pump regime (T

In Situ Synthesis of Gold Nanoparticles on Wool Powder and Their Catalytic Application.

PubMed

Tang, Bin; Zhou, Xu; Zeng, Tian; Lin, Xia; Zhou, Ji; Ye, Yong; Wang, Xungai

2017-03-15

Gold nanoparticles (AuNPs) were synthesized in situ on wool powder (WP) under heating conditions. Wool powder not only reduced Au ions to AuNPs, but also provided a support for as-synthesized AuNPs. WPs were treated under different concentrations of Au ions, and corresponding optical features and morphologies of the treated WPs were investigated by UV-VIS diffuse reflectance absorption spectroscopy and scanning electron microscopy (SEM). X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and transmission electron microscope (TEM) were also employed to characterize the WP treated with AuNPs. The results demonstrate that AuNPs were produced in the presence of WP and distributed over the wool particles. The porous structure led to the synthesis of AuNPs in the internal parts of WP. Acid conditions and high temperature facilitated the synthesis of AuNPs by WP in aqueous solution. The reducibility of wool was improved after being converted to powder from fibers, due to exposure of more active groups. Moreover, the obtained AuNP-WP complexes showed significant catalytic activity to accelerate the reduction reaction of 4-nitrophenol (4-NP) by sodium borohydride (NaBH₄).

Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo

PubMed Central

Karpel-Massler, Georg; Banu, Matei A.; Shu, Chang; Halatsch, Marc-Eric; Westhoff, Mike-Andrew; Bruce, Jeffrey N.; Canoll, Peter; Siegelin, Markus D.

2016-01-01

It remains a challenge in oncology to identify novel drug regimens to efficiently tackle glioblastoma, the most common primary brain tumor in adults. Here, we target deubiquitinases for glioblastoma therapy by utilizing the small-molecule inhibitor WP1130 which has been characterized as a deubiquitinase inhibitor that interferes with the function of Usp9X. Expression analysis data confirm that Usp9X expression is increased in glioblastoma compared to normal brain tissue indicating its potential as a therapeutic. Consistently, increasing concentrations of WP1130 decrease the cellular viability of established, patient-derived xenograft (PDX) and stem cell-like glioblastoma cells. Specific down-regulation of Usp9X reduces viability in glioblastoma cells mimicking the effects of WP1130. Mechanistically, WP1130 elicits apoptosis and increases activation of caspases. Moreover, WP1130 and siRNAs targeting Usp9X reduce the expression of anti-apoptotic Bcl-2 family members and Inhibitor of Apoptosis Proteins, XIAP and Survivin. Pharmacological and genetic interference with Usp9X efficiently sensitized glioblastoma cells to intrinsic and extrinsic apoptotic stimuli. In addition, single treatment with WP1130 elicited anti-glioma activity in an orthotopic proneural murine model of glioblastoma. Finally, the combination treatment of WP1130 and ABT263 inhibited tumor growth more efficiently than each reagent by its own in vivo without detectable side effects or organ toxicity. Taken together, these results suggest that targeting deubiquitinases for glioma therapy is feasible and effective. PMID:26872380

Dried whole-plant Artemisia annua slows evolution of malaria drug resistance and overcomes resistance to artemisinin

PubMed Central

Elfawal, Mostafa A.; Towler, Melissa J.; Reich, Nicholas G.; Weathers, Pamela J.; Rich, Stephen M.

2015-01-01

Pharmaceutical monotherapies against human malaria have proven effective, although ephemeral, owing to the inevitable evolution of resistant parasites. Resistance to two or more drugs delivered in combination will evolve more slowly; hence combination therapies have become the preferred norm in the fight against malaria. At the forefront of these efforts has been the promotion of Artemisinin Combination Therapy, but despite these efforts, resistance to artemisinin has begun to emerge. In 2012, we demonstrated the efficacy of the whole plant (WP)—not a tea, not an infusion—as a malaria therapy and found it to be more effective than a comparable dose of pure artemisinin in a rodent malaria model. Here we show that WP overcomes existing resistance to pure artemisinin in the rodent malaria Plasmodium yoelii. Moreover, in a long-term artificial selection for resistance in Plasmodium chabaudi, we tested resilience of WP against drug resistance in comparison with pure artemisinin (AN). Stable resistance to WP was achieved three times more slowly than stable resistance to AN. WP treatment proved even more resilient than the double dose of AN. The resilience of WP may be attributable to the evolutionary refinement of the plant’s secondary metabolic products into a redundant, multicomponent defense system. Efficacy and resilience of WP treatment against rodent malaria provides compelling reasons to further explore the role of nonpharmaceutical forms of AN to treat human malaria. PMID:25561559

Can the GEOS CCM Simulate the Temperature Response to Warm Pool El Nino Events in the Antarctic Stratosphere?

NASA Technical Reports Server (NTRS)

Hurwitz, M. M.; Song, I.-S.; Oman, L. D.; Newman, P. A.; Molod, A. M.; Frith, S. M.; Nielsen, J. E.

2010-01-01

"Warm pool" (WP) El Nino events are characterized by positive sea surface temperature (SST) anomalies in the central equatorial Pacific. During austral spring. WP El Nino events are associated with an enhancement of convective activity in the South Pacific Convergence Zone, provoking a tropospheric planetary wave response and thus increasing planetary wave driving of the Southern Hemisphere stratosphere. These conditions lead to higher polar stratospheric temperatures and to a weaker polar jet during austral summer, as compared with neutral ENSO years. Furthermore, this response is sensitive to the phase of the quasi-biennial oscillation (QBO): a stronger warming is seen in WP El Nino events coincident with the easterly phase of the quasi-biennial oscillation (QBO) as compared with WP El Nino events coincident with a westerly or neutral QBO. The Goddard Earth Observing System (GEOS) chemistry-climate model (CCM) is used to further explore the atmospheric response to ENSO. Time-slice simulations are forced by composited SSTs from observed WP El Nino and neutral ENSO events. The modeled eddy heat flux, temperature and wind responses to WP El Nino events are compared with observations. A new gravity wave drag scheme has been implemented in the GEOS CCM, enabling the model to produce a realistic, internally generated QBO. By repeating the above time-slice simulations with this new model version, the sensitivity of the WP El Nino response to the phase of the quasi-biennial oscillation QBO is estimated.

Extremely large magnetoresistance in the topologically trivial semimetal α -WP2

NASA Astrophysics Data System (ADS)

Du, Jianhua; Lou, Zhefeng; Zhang, ShengNan; Zhou, Yuxing; Xu, Binjie; Chen, Qin; Tang, Yanqing; Chen, Shuijin; Chen, Huancheng; Zhu, Qinqing; Wang, Hangdong; Yang, Jinhu; Wu, QuanSheng; Yazyev, Oleg V.; Fang, Minghu

2018-06-01

Extremely large magnetoresistance (XMR) was recently discovered in many nonmagnetic materials, while its underlying mechanism remains poorly understood due to the complex electronic structure of these materials. Here we report an investigation of the α -phase WP2, a topologically trivial semimetal with monoclinic crystal structure (C 2 /m ), which contrasts with the recently discovered robust type-II Weyl semimetal phase in β -WP2 . We found that α -WP2 exhibits almost all the characteristics of XMR materials: the near-quadratic field dependence of MR, a field-induced up-turn in resistivity followed by a plateau at low temperature, which can be understood by the compensation effect, and high mobility of carriers confirmed by our Hall effect measurements. It was also found that the normalized MRs under different magnetic fields have the same temperature dependence in α -WP2 , the Kohler scaling law can describe the MR data in a wide temperature range, and there is no obvious change in the anisotropic parameter γ value with temperature. The resistance polar diagram has a peanut shape when the field is rotated in the a c plane, which can be understood by the anisotropy of the Fermi surface. These results indicate that both field-induced-gap and temperature-induced Lifshitz transition are not the origin of up-turn in resistivity in the α -WP2 semimetal. Our findings establish α -WP2 as a new reference material for exploring the XMR phenomena.

A water-soluble pillar[5]arene as a new carrier for an old drug.

PubMed

Barbera, Lucia; Franco, Domenico; De Plano, Laura M; Gattuso, Giuseppe; Guglielmino, Salvatore P P; Lentini, Germana; Manganaro, Nadia; Marino, Nino; Pappalardo, Sebastiano; Parisi, Melchiorre F; Puntoriero, Fausto; Pisagatti, Ilenia; Notti, Anna

2017-04-11

The remarkable affinity of deca-carboxylatopillar[5]arene WP5 towards the aminoglycoside antibiotic, amikacin, in aqueous media is reported; in vitro studies on Gram-positive bacteria (Staphylococcus aureus) show that drug entrapment inside WP5 also takes place in the presence of the microrganisms, thus pointing to WP5 as an appealing carrier for amikacin targeted delivery.

Effects of leucine-enriched essential amino acid and whey protein bolus dosing upon skeletal muscle protein synthesis at rest and after exercise in older women.

PubMed

Wilkinson, Daniel J; Bukhari, Syed S I; Phillips, Bethan E; Limb, Marie C; Cegielski, Jessica; Brook, Matthew S; Rankin, Debbie; Mitchell, William K; Kobayashi, Hisamine; Williams, John P; Lund, Jonathan; Greenhaff, Paul L; Smith, Kenneth; Atherton, Philip J

2017-09-23

Impaired anabolic responses to nutrition and exercise contribute to loss of skeletal muscle mass with ageing (sarcopenia). Here, we tested responses of muscle protein synthesis (MPS), in the under represented group of older women, to leucine-enriched essential amino acids (EAA) in comparison to a large bolus of whey protein (WP). Twenty-four older women (65 ± 1 y) received (N = 8/group) 1.5 g leucine-enriched EAA supplements (LEAA_1.5), 6 g LEAA (LEAA_6) in comparison to 40 g WP. A primed constant I.V infusion of 13 C 6 -phenylalanine was used to determine MPS at baseline and in response to feeding (FED) and feeding-plus-exercise (FED-EX; 6 × 8 unilateral leg extensions; 75%1-RM). We quantified plasma insulin/AA concentrations, leg femoral blood flow (LBF)/muscle microvascular blood flow (MBF), and anabolic signalling via immunoblotting. Plasma insulineamia and EAAemia were greater and more prolonged with WP than LEAA, although LEAA_6 peaked at similar levels to WP. Neither LEAA or WP modified LBF or MBF. FED increased MPS similarly in the LEAA_1.5, LEAA_6 and WP (P < 0.05) groups over 0-2 h, with MPS significantly higher than basal in the LEAA_6 and WP groups only over 0-4 h. However, FED-EX increased MPS similarly across all the groups from 0 to 4 h (P < 0.05). Only p-p70S6K1 increased with WP at 2 h in FED (P < 0.05), and at 2/4 h in FED-EX (P < 0.05). In conclusion, LEAA_1.5, despite only providing 0.6 g of leucine, robustly (perhaps maximally) stimulated MPS, with negligible trophic advantage of greater doses of LEAA or even to 40 g WP. Highlighting that composition of EAA, in particular the presence of leucine rather than amount is most crucial for anabolism. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Early Activation of Apoptosis and Caspase-independent Cell Death Plays an Important Role in Mediating the Cytotoxic and Genotoxic Effects of WP 631 in Ovarian Cancer Cells.

PubMed

Gajek, Arkadiusz; Denel-Bobrowska, Marta; Rogalska, Aneta; Bukowska, Barbara; Maszewski, Janusz; Marczak, Agnieszka

2015-01-01

The purpose of this study was to provide a detailed explanation of the mechanism of bisanthracycline,?WP 631 in comparison to doxorubicin (DOX), a first generation anthracycline, currently the most widely used pharmaceutical in clinical oncology. Experiments were performed in SKOV-3 ovarian cancer cells which are otherwise resistant to standard drugs such as cis-platinum and adriamycin. As attention was focused on the ability of WP 631 to induce apoptosis, this was examined using a double staining method with Annexin V and propidium iodide probes, with measurement of the level of intracellular calcium ions and cytosolic cytochrome c. The western blotting technique was performed to confirm PARP cleavage. We also investigated the involvement of caspase activation and DNA degradation (comet assay and immunocytochemical detection of phosphorylated H2AX histones) in the development of apoptotic events. WP 631 demonstrated significantly higher effectiveness as a pro-apoptotic drug than DOX. This was evident in the higher levels of markers of apoptosis, such as the externalization of phosphatidylserine and the elevated level of cytochrome c. An extension of incubation time led to an increase in intracellular calcium levels after treatment with DOX. Lower changes in the calcium content were associated with the influence of WP 631. DOX led to the activation of all tested caspases, 8, 9 and 3, whereas WP 631 only induced an increase in caspase 8 activity after 24h of treatment and consequently led to the cleavage of PARP. The lack of active caspase 3 had no outcome on the single and double-stranded DNA breaks. The obtained results show that WP 631 was considerably more genotoxic towards the investigated cell line than DOX. This effect was especially visible after longer times of incubation. The above detailed studies indicate that WP 631 generates early apoptosis and cell death independent of caspase-3, detected at relatively late time points. The observed differences in the mechanisms of the action of WP631 and DOX suggest that this bisanthracycline can be an effective alternative in ovarian cancer treatment.

Personality factors and weight preoccupation: a continuum approach to the association between eating disorders and personality disorders.

PubMed

Davis, C; Claridge, G; Cerullo, D

1997-01-01

Evidence shows a high comorbidity of eating disorders and some forms of personality disorder. Adopting a dimensional approach to both, our study explored their connection among a non-clinical sample. 191 young women completed personality scales of general neuroticism, and of borderline, schizotypal, obsessive-compulsive, and narcissistic (both adjustive and maladaptive) traits. Weight preoccupation (WP), as a normal analogue of eating disorders, was assessed with scales from the Eating Disorder Inventory, and height and weight measured. The data were analysed with multiple regression techniques, with WP as the dependent variable. In low to normal weight subjects, after controlling for the significant influence of body mass, the specific predictors of WP in the regression model were borderline personality and maladaptive narcissism, in the positive direction, and adjustive narcissism and obsessive-compulsiveness in the negative direction. In heavier women, narcissism made no contribution--nor, more significantly, did body mass. Patterns of association between eating pathology and personality disorder, especially borderline and narcissism, can be clearly mapped across to personality traits in the currently non-clinical population. This finding has important implications for understanding dynamics of, and identifying individuals at risk for, eating disorders.

JPRS Report, East Europe.

DTIC Science & Technology

1988-04-12

the Polish Army Main Political Board [ GZP WP], Gen Tadeusz Szacilo, participated in the briefing. On the first day of the conference—Vice Admiral...Lud- wik Dutkowski, first deputy chief of the GZP WP, participated—participants heard many interesting JPRS-EER-88-030 12 April 1988...in these areas were presented by deputy chief of the GZP WP Brig Gen Tadeusz Kojder and Brig Gen Dr Leslaw Wojtasik. Much attention was devoted to

Structural control on the emplacement of contemporaneous Sn-Ta-Nb mineralized LCT pegmatites and Sn bearing quartz veins: Insights from the Musha and Ntunga deposits of the Karagwe-Ankole Belt, Rwanda

NASA Astrophysics Data System (ADS)

Hulsbosch, Niels; Van Daele, Johanna; Reinders, Nathan; Dewaele, Stijn; Jacques, Dominique; Muchez, Philippe

2017-10-01

The Nb-Ta-Sn pegmatites and Sn quartz veins of the Rwamagana-Musha-Ntunga area in eastern Rwanda are part of the Mesoproterozoic Karagwe-Ankole Belt. These commodities are on a regional scale spatiotemporally associated to the early Neoproterozoic fertile G4-granite generation. Although a transition from the lithium-cesium-tantalum pegmatites to cassiterite-microcline-quartz veins has been observed in the Rwamagana-Musha-Ntunga area, the structural control and the paragenetic relationship between the mineralized pegmatites and the Sn bearing quartz veins is largely unknown. Consequently, this study investigates the occurrence of pegmatites and quartz veins and the structural and lithological controls on their emplacement. The metasediments in the area are affected by a regional compressional regime with a shortening direction oriented N70E, which resulted in a N20W-oriented fold sequence. The Lake Muhazi granite is present in center of the Karehe anticline. The structural orientations of pegmatites and quartz veins show that two important factors control their emplacement. The first control is the reactivation of pre-existing discontinuities such as the bedding, bedding-parallel joints or strike-slip fault planes. In view of the regional structural grain in the Rwamagana-Musha-Ntunga area, this corresponds with abundant N20W-oriented pegmatites and quartz veins. The reactivation is strongly related to the lithology of the host rocks. The Musha Formation, which mainly consists of decimeter- to meter-scale lithological alternations of metapelite, metasiltstone and metasandstone, represents the most suitable environment for bedding reactivation. This is reflected in the predominance of bedding-parallel pegmatites and quartz veins hosted by the Musha Formation. Strike-parallel joints were mainly observed in the competent lithologies. The second controlling factor is related to the regional post-compressional stress regime. New joints initiated upon emplacement of the pegmatites and quartz veins. The orientations of these joints are influenced by the regional stress regime and resulted in steep EW-oriented pegmatites and quartz veins in the Rwamagana-Musha-Ntunga area. The pegmatites and quartz veins are interpreted as being initiated upon emplacement under influence of the prevailing regional stress regime. This post-compressional stress regime is characterized by a subvertical maximum compressive stress.

Solid-state vs water-perfused catheters to measure colonic high-amplitude propagating contractions.

PubMed

Liem, O; Burgers, R E; Connor, F L; Benninga, M A; Reddy, S N; Mousa, H M; Di Lorenzo, C

2012-04-01

  Solid-state (SS) manometry catheters with portable data loggers offer many potential advantages over traditional water-perfused (WP) systems, such as prolonged recordings in a more physiologic ambulatory setting and the lack of risk for water overload. The use of SS catheters has not been evaluated in comparison with perfused catheters in children. This study aims to compare data provided by SS and WP catheters in children undergoing colonic manometry studies.   A SS catheter and a WP catheter were taped together such that their corresponding sensors were at the same location. Simultaneous recordings were obtained using the SS and WP catheters (both 8 channels, 10 cm apart) in 15 children with severe defecation disorders referred for colonic manometry. Signals were recorded for a minimum of 1 h during fasting, 1 h after ingestion of a meal, and 1 h after the administration of bisacodyl. Solid-state signals from the data logger were analyzed against the perfused signals. All high-amplitude propagated contractions (HAPCs), the most recognizable and interpreted colonic motor event, were evaluated for spatial and temporal features including their durations, amplitudes, and propagation velocities.   A total of 107 HAPCs were detected with SS and 91 with WP catheters. All WP-HAPC were also observed with SS. Linear regression analysis showed that SS catheters tended to give higher readings in the presence of amplitudes <102 mmHg and lower reading with amplitudes >102 mmHg. An opposite trend was found for the duration of contractions. No significant difference was found for HAPC velocity.   SS catheters are more sensitive in recording HAPCs in children with defecation disorders compared with the more traditional WP assembly. There is a difference in measurements of amplitude between the two systems. Solid-state catheters offer potential advantages over WP catheters in children, being portable, safer to use, and may provide data over a more prolonged period. © 2012 Blackwell Publishing Ltd.

Deep-Sea Bacterium Shewanella piezotolerans WP3 Has Two Dimethyl Sulfoxide Reductases in Distinct Subcellular Locations

PubMed Central

Xiong, Lei; Jian, Huahua

2017-01-01

ABSTRACT Dimethyl sulfoxide (DMSO) acts as a substantial sink for dimethyl sulfide (DMS) in deep waters and is therefore considered a potential electron acceptor supporting abyssal ecosystems. Shewanella piezotolerans WP3 was isolated from west Pacific deep-sea sediments, and two functional DMSO respiratory subsystems are essential for maximum growth of WP3 under in situ conditions (4°C/20 MPa). However, the relationship between these two subsystems and the electron transport pathway underlying DMSO reduction by WP3 remain unknown. In this study, both DMSO reductases (type I and type VI) in WP3 were found to be functionally independent despite their close evolutionary relationship. Moreover, immunogold labeling of DMSO reductase subunits revealed that the type I DMSO reductase was localized on the outer leaflet of the outer membrane, whereas the type VI DMSO reductase was located within the periplasmic space. CymA, a cytoplasmic membrane-bound tetraheme c-type cytochrome, served as a preferential electron transport protein for the type I and type VI DMSO reductases, in which type VI accepted electrons from CymA in a DmsE- and DmsF-independent manner. Based on these results, we proposed a core electron transport model of DMSO reduction in the deep-sea bacterium S. piezotolerans WP3. These results collectively suggest that the possession of two sets of DMSO reductases with distinct subcellular localizations may be an adaptive strategy for WP3 to achieve maximum DMSO utilization in deep-sea environments. IMPORTANCE As the dominant methylated sulfur compound in deep oceanic water, dimethyl sulfoxide (DMSO) has been suggested to play an important role in the marine biogeochemical cycle of the volatile anti-greenhouse gas dimethyl sulfide (DMS). Two sets of DMSO respiratory systems in the deep-sea bacterium Shewanella piezotolerans WP3 have previously been identified to mediate DMSO reduction under in situ conditions (4°C/20 MPa). Here, we report that the two DMSO reductases (type I and type VI) in WP3 have distinct subcellular localizations, in which type I DMSO reductase is localized to the exterior surface of the outer membrane and type VI DMSO reductase resides in the periplasmic space. A core electron transport model of DMSO reduction in WP3 was constructed based on genetic and physiological data. These results will contribute to a comprehensive understanding of the adaptation mechanisms of anaerobic respiratory systems in benthic microorganisms. PMID:28687647

The relationship between magnetic anisotropy, rock-strength anisotropy and vein emplacement in gold-bearing metabasalts of Gadag (South India)

NASA Astrophysics Data System (ADS)

Vishnu, C. S.; Lahiri, Sivaji; Mamtani, Manish A.

2018-01-01

In this study the importance of rock strength and its anisotropy in controlling vein emplacement is evaluated by integrating anisotropy of magnetic susceptibility (AMS) with rock mechanics data from massive (visibly isotropic) metabasalts of Gadag region (Dharwar Craton, South India). Orientation of magnetic foliation (MF) is first recognized from AMS. Subsequently, rock mechanics tests viz. ultrasonic P-wave velocity (Vp), uniaxial compressive strength (UCS) and point load strength (Is(50)) are done in cores extracted parallel and perpendicular to MF. Vp is found to be higher in direction parallel to MF than perpendicular to it. In contrast rock strength (UCS and Is(50)) is greater in direction perpendicular to MF, than parallel to it. This proves that rocks from the gold mineralized belt of Gadag have rock strength anisotropy. Orientation of MF in Gadag region is NW-SE, which is also the mean orientation of quartz veins. Previous studies indicate that emplacement of veins in the region took place during regional D3 (NW-SE shortening). Based on the present study, it is concluded that vein emplacement took place in NW-SE orientation because the rocks have strength anisotropy and are weaker in this direction (orientation of MF), which dilated to accommodate fluid flow. In addition, vein intensities are measured along three traverses and found to be variable. It is argued that since mineralization is favoured when the system gets saturated with fluid, variation in fluid flow could not have been responsible for variation in vein intensities in the study area. Since the rock strength of the different blocks investigated here is not uniform, it is envisaged that variation in rock strength played an important role in controlling the vein intensities. It is concluded that rock strength variation controlled strain partitioning and channelized fluid flow thus influencing vein emplacement and mineralization and formation of lodes.

MISSILE DATA COMPENDIUM (DATCOM) User Manual 2014 Revision

DTIC Science & Technology

2014-10-01

2014 revision of the Missile Datcom computer program. It supersedes AFRL-RB- WP-TR-2011-3071. 15. SUBJECT TERMS aerodynamics , stability and control...45 3.1.8 Namelist TRIM - Trim Aerodynamics ............................................................. 46 3.1.9... Aerodynamic Output Summary .......................... 64 4.2 PARTIAL OUTPUT

Sovereign Debt in Advanced Economies: Overview and Issues for Congress

DTIC Science & Technology

2013-10-28

the usefulness of that explanation. See Ugo Panizza , Federico Sturzenegger, and Jeromin Zettelmeyer, “The Economics and Law of Sovereign Debt and...Eduardo Borensztein and Ugo Panizza , The Costs of Sovereign Default, IMF Working Paper, WP/08/238, http://www.imf.org/external/pubs/ft/wp/2008/wp08238...Lessons from a Decade of Crises (Cambridge, MA: MIT Press, 2007). 18 Barry Eichengreen, Ricardo Hausmann, and Ugo Panizza , Currency Mismatches, Debt

Updated reduced CMB data and constraints on cosmological parameters

NASA Astrophysics Data System (ADS)

Cai, Rong-Gen; Guo, Zong-Kuan; Tang, Bo

2015-07-01

We obtain the reduced CMB data {lA, R, z∗} from WMAP9, WMAP9+BKP, Planck+WP and Planck+WP+BKP for the ΛCDM and wCDM models with or without spatial curvature. We then use these reduced CMB data in combination with low-redshift observations to put constraints on cosmological parameters. We find that including BKP results in a higher value of the Hubble constant especially when the equation of state (EOS) of dark energy and curvature are allowed to vary. For the ΛCDM model with curvature, the estimate of the Hubble constant with Planck+WP+Lensing is inconsistent with the one derived from Planck+WP+BKP at about 1.2σ confidence level (CL).

Contrasting precipitation seasonality influences evapotranspiration dynamics in water-limited shrublands

NASA Astrophysics Data System (ADS)

Villarreal, Samuel; Vargas, Rodrigo; Yepez, Enrico A.; Acosta, Jose S.; Castro, Angel; Escoto-Rodriguez, Martin; Lopez, Eulogio; Martínez-Osuna, Juan; Rodriguez, Julio C.; Smith, Stephen V.; Vivoni, Enrique R.; Watts, Christopher J.

2016-02-01

Water-limited ecosystems occupy nearly 30% of the Earth, but arguably, the controls on their ecosystem processes remain largely uncertain. We analyzed six site years of eddy covariance measurements of evapotranspiration (ET) from 2008 to 2010 at two water-limited shrublands: one dominated by winter precipitation (WP site) and another dominated by summer precipitation (SP site), but with similar solar radiation patterns in the Northern Hemisphere. We determined how physical forcing factors (i.e., net radiation (Rn), soil water content (SWC), air temperature (Ta), and vapor pressure deficit (VPD)) influence annual and seasonal variability of ET. Mean annual ET at SP site was 455 ± 91 mm yr-1, was mainly influenced by SWC during the dry season, by Rn during the wet season, and was highly sensitive to changes in annual precipitation (P). Mean annual ET at WP site was 363 ± 52 mm yr-1, had less interannual variability, but multiple variables (i.e., SWC, Ta, VPD, and Rn) were needed to explain ET among years and seasons. Wavelet coherence analysis showed that ET at SP site has a consistent temporal coherency with Ta and P, but this was not the case for ET at WP site. Our results support the paradigm that SWC is the main control of ET in water-limited ecosystems when radiation and temperature are not the limiting factors. In contrast, when P and SWC are decoupled from available energy (i.e., radiation and temperature), then ET is controlled by an interaction of multiple variables. Our results bring attention to the need for better understanding how climate and soil dynamics influence ET across these globally distributed ecosystems.

Closed Loop Control of Oxygen Delivery and Oxygen Generation

DTIC Science & Technology

2017-08-01

AFRL-SA-WP-SR-2017-0024 Closed Loop Control of Oxygen Delivery and Oxygen Generation Dr. Jay Johannigman1, Richard Branson1...for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO...TITLE AND SUBTITLE Closed Loop Control of Oxygen Delivery and Oxygen Generation 5a. CONTRACT NUMBER FA8650-10-2-6140 5b. GRANT NUMBER

Oral sensitization to whey proteins induces age- and sex-dependent behavioral abnormality and neuroinflammatory responses in a mouse model of food allergy: a potential role of mast cells.

PubMed

Germundson, Danielle L; Smith, Nicholas A; Vendsel, Lane P; Kelsch, Andrea V; Combs, Colin K; Nagamoto-Combs, Kumi

2018-04-23

Growing evidence has strengthened the association of food allergy with neuropsychiatric symptoms such as depression, anxiety, and autism. However, underlying mechanisms by which peripheral allergic responses lead to behavioral dysfunction are yet to be determined. Allergen-activated mast cells may serve as mediators by releasing histamine and other inflammatory factors that could adversely affect brain function. We hypothesized that eliciting food allergy in experimental animals would result in behavioral changes accompanied by mast cell accumulation in the brain. Our hypothesis was tested in a mouse model of milk allergy using bovine milk whey proteins (WP) as the allergen. Male and female C57BL/6 mice at 4 weeks (young) and 10 months (old) of age underwent 5-week WP sensitization with weekly intragastric administration of 20 mg WP and 10 μg cholera toxin as an adjuvant. Age-matched sham animals were given the vehicle containing only the adjuvant. All animals were orally challenged with 50 mg WP in week 6 and their intrinsic digging behavior was assessed the next day. Animals were sacrificed 3 days after the challenge, and WP-specific serum IgE, intestinal and brain mast cells, glial activation, and epigenetic DNA modification in the brain were examined. WP-sensitized males showed significantly less digging activity than the sham males in both age groups while no apparent difference was observed in females. Mast cells and their activities were evident in the intestines in an age- and sex-dependent manner. Brain mast cells were predominantly located in the region between the lateral midbrain and medial hippocampus, and their number increased in the WP-sensitized young, but not old, male brains. Noticeable differences in for 5-hydroxymethylcytosine immunoreactivity were observed in WP mice of both age groups in the amygdala, suggesting epigenetic regulation. Increased microglial Iba1 immunoreactivity and perivascular astrocytes hypertrophy were also observed in the WP-sensitized old male mice. Our results demonstrated that food allergy induced behavioral abnormality, increases in the number of mast cells, epigenetic DNA modification in the brain, microgliosis, and astrocyte hypertrophy in a sex- and age-dependent manner, providing a potential mechanism by which peripheral allergic responses evoke behavioral dysfunction.

Need for Robust Sensors for Inherently Fail-Safe Gas Turbine Engine Controls, Monitoring, and Prognostics (Postprint)

DTIC Science & Technology

2006-09-01

MONITORING , AND PROGNOSTICS Alireza R. Behbahani Controls / Engine Health Management Turbine Engine Division / PRTS U.S. Air Force Research...Technical Report 2005. 8. Greitzer, Frank et al, “Gas Turbine Engine Health Monitoring and Prognostics ”, International Society of Logistics (SOLE...AFRL-PR-WP-TP-2007-217 NEED FOR ROBUST SENSORS FOR INHERENTLY FAIL-SAFE GAS TURBINE ENGINE CONTROLS, MONITORING , AND PROGNOSTICS (POSTPRINT

Two Beam Energy Exchange in Hybrid Liquid Crystal Cells with Photorefractive Field Controlled Boundary Conditions (Postprint)

DTIC Science & Technology

2016-09-12

AFRL-RX-WP-JA-2017-0209 TWO BEAM ENERGY EXCHANGE IN HYBRID LIQUID CRYSTAL CELLS WITH PHOTOREFRACTIVE FIELD CONTROLLED BOUNDARY...estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the... CRYSTAL CELLS WITH PHOTOREFRACTIVE FIELD CONTROLLED BOUNDARY CONDITIONS (POSTPRINT) 5a. CONTRACT NUMBER FA8650-16-D-5402-0001 5b. GRANT

Whole-Pelvis or Bladder-Only Chemoradiation for Lymph Node-Negative Invasive Bladder Cancer: Single-Institution Experience

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tunio, Mutahir A., E-mail: drmutahirtonio@hotmail.com; Hashmi, Altaf; Qayyum, Abdul

2012-03-01

Purpose: Whole-pelvis (WP) concurrent chemoradiation (CCRT) is the standard bladder preserving option for patients with invasive bladder cancer. The standard practice is to treat elective pelvic lymph nodes, so our aim was to evaluate whether bladder-only (BO) CCRT leads to results similar to those obtained by standard WP-CCRT. Methods and Materials: Patient eligibility included histopathologically proven muscle-invasive bladder cancer, lymph nodes negative (T2-T4, N-) by radiology, and maximal transurethral resection of bladder tumor with normal hematologic, renal, and liver functions. Between March 2005 and May 2006, 230 patients were accrued. Patients were randomly assigned to WP-CCRT (120 patients) and BO-CCRTmore » (110 patients). Data regarding the toxicity profile, compliance, initial complete response rates at 3 months, and occurrence of locoregional or distant failure were recorded. Results: With a median follow-up time of 5 years (range, 3-6), WP-CCRT was associated with a 5-year disease-free survival of 47.1% compared with 46.9% in patients treated with BO-CCRT (p = 0.5). The bladder preservation rates were 58.9% and 57.1% in WP-CCRT and BO-CCRT, respectively (p = 0.8), and the 5-year overall survival rates were 52.9% for WP-CCRT and 51% for BO-CCRT (p = 0.8). Conclusion: BO-CCRT showed similar rates of bladder preservation, disease-free survival, and overall survival rates as those of WP-CCRT. Smaller field sizes including bladder with 2-cm margins can be used as bladder preservation protocol for patients with muscle-invasive lymph node-negative bladder cancer to minimize the side effects of CCRT.« less

Factors associated with participation in and benefits of a worksite wellness program.

PubMed

Merrill, Ray M; Hull, John D

2013-08-01

The objective of this study was to describe employees most likely to participate in a Personal Wellness Profile (PWP) and/or in a worksite Wellness Program (WP), and to identify whether an association exists between participation and trends in number of health care services and cost of services per person. A retrospective cohort study was conducted using medical claims data from the Deseret Mutual Benefit Administrators, 2004 through 2009. The PWP and WP involved more than 30% of employee contract holders. Participation in the PWP and WP were lower in the older age group and higher among women, married people, and those with an annual income of at least $40,000. Average annual cost per person during 2004-2006 was significantly positively associated with completing the PWP in 2007-2009. Those in the highest quartile for average annual cost per person in 2004-2006 were significantly less likely to participate in the WP in 2007-2009. During 2004-2009, a significantly increasing trend in average annual cost per person was similar, but at a lower level for PWP participants. The trend line also was lower for WP participants, and increased at a lower rate. The lower rate of increase in the trends for average cost per person among those in the WP indicates that the intervention is effective at slowing escalating costs. Additional years of data should be assessed, when available, to confirm this pattern.

Culture-dependent and culture-independent analyses reveal no prokaryotic community shifts or recovery of Serratia marcescens in Acropora palmata with white pox disease.

PubMed

Lesser, Michael P; Jarett, Jessica K

2014-06-01

Recently, the etiological agent of white pox (WP) disease, also known as acroporid serratiosis, in the endangered coral Acropora palmata is the enteric bacterium Serratia marcescens with the source being localized sewage release onto coastal coral reef communities. Here, we show that both culture-dependent and culture-independent approaches could not recover this bacterium from samples of tissue and mucus from A. palmata colonies affected by WP disease in the Bahamas, or seawater collected adjacent to A. palmata colonies. Additionally, a metagenetic 16S rRNA pyrosequencing study shows no significant difference in the bacterial communities of coral tissues with and without WP lesions. As recent studies have shown for other coral diseases, S. marcescens cannot be identified in all cases of WP disease in several geographically separated populations of A. palmata with the same set of signs. As a result, its identification as the etiological agent of WP disease, and cause of a reverse zoonosis, cannot be broadly supported. However, the prevalence of WP disease associated with S. marcescens does appear to be associated with proximity to population centers, and research efforts should be broadened to examine this association, and to identify other causes of this syndrome. © 2014 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved.

Transverse Myelitis Association

MedlinePlus

... INSPIRATION What is Anti-Myelin Oligodendrocyte Glycoprotein (MOG)? https://myelitis.org/wp-content/uploads/2015/05/blog_research.jpg 999 1500 The TMA https://myelitis.org/wp-content/uploads/2015/06/TMA- ...

Interaction between casein micelles and whey protein/κ-casein complexes during renneting of heat-treated reconstituted skim milk powder and casein micelle/serum mixtures.

PubMed

Kethireddipalli, Prashanti; Hill, Arthur R; Dalgleish, Douglas G

2011-02-23

Casein micelles were separated from unheated reconstituted skim milk powder (RSMP) and were resuspended in the serum of RSMP that had been heated, with and without dialysis of this serum against unheated RSMP. Using size-exclusion chromatography, it was found that the soluble complexes of whey protein (WP) with κ-casein in the serum of the heated milk bind progressively to unheated casein micelles during renneting, even prior to the onset of clotting. Similar trends were noted when casein micelles from RSMP heated at pH values of 6.7, 7.1, or 6.3, each with different amounts of WP coating the micelles, were renneted in the presence of soluble WP/κ-casein complexes. No matter what was the initial load of micelle-bound WP complexes, all micelle types were capable of binding additional serum protein complexes during renneting. However, it is not clear that this binding of WP/κ-casein complexes to the micellar surface is a direct cause of the impaired rennet clotting of the RSMP.

Deep Borehole Field Test Requirements and Controlled Assumptions.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hardin, Ernest

2015-07-01

This document presents design requirements and controlled assumptions intended for use in the engineering development and testing of: 1) prototype packages for radioactive waste disposal in deep boreholes; 2) a waste package surface handling system; and 3) a subsurface system for emplacing and retrieving packages in deep boreholes. Engineering development and testing is being performed as part of the Deep Borehole Field Test (DBFT; SNL 2014a). This document presents parallel sets of requirements for a waste disposal system and for the DBFT, showing the close relationship. In addition to design, it will also inform planning for drilling, construction, and scientificmore » characterization activities for the DBFT. The information presented here follows typical preparations for engineering design. It includes functional and operating requirements for handling and emplacement/retrieval equipment, waste package design and emplacement requirements, borehole construction requirements, sealing requirements, and performance criteria. Assumptions are included where they could impact engineering design. Design solutions are avoided in the requirements discussion. Deep Borehole Field Test Requirements and Controlled Assumptions July 21, 2015 iv ACKNOWLEDGEMENTS This set of requirements and assumptions has benefited greatly from reviews by Gordon Appel, Geoff Freeze, Kris Kuhlman, Bob MacKinnon, Steve Pye, David Sassani, Dave Sevougian, and Jiann Su.« less

Efficacy of double mirrored omega pattern for skin sparing mastectomy to reduce ischemic complications.

PubMed

Santanelli di Pompeo, Fabio; Sorotos, Michail; Laporta, Rosaria; Pagnoni, Marco; Longo, Benedetto

2018-02-01

Excellent cosmetic results from skin-sparing mastectomy (SSM) are often impaired by skin flaps' necrosis (SFN), from 8%-25% or worse in smokers. This study prospectively investigated the efficacy of Double-Mirrored Omega Pattern (DMOP-SSM) compared to Wise Pattern SSM (WP-SSM) for immediate reconstruction in moderate/large-breasted smokers. From 2008-2010, DMOP-SSM was performed in 51 consecutive immediate breast reconstructions on 41 smokers (mean age = 49.8 years) with moderate/large and ptotic breasts. This active group (AG) was compared to a similar historical control group (CG) of 37 smokers (mean age = 51.1 years) who underwent WP-SSM and immediate breast reconstruction, with a mean follow-up of 37.6 months. Skin ischaemic complications, number of surgical revisions, time to wound healing, and patient satisfaction were analysed. Descriptive statistics were reported and comparison of performance endpoints was performed using Fisher's exact test and Mann-Whitney U-test. A p-value <.05 was considered significant. Patients' mean age (p = .316) and BMI (p = .215) were not statistically different between groups. Ischaemic complications occurred in 11.7% of DMOP-SSMs and in 32.4% of WP-SSMs (p = .017), and revision rates were, respectively, 5.8% and 24.3% (p = .012), both statistically significant. Mean time to wound healing was, respectively, 16.8 days and 18.4 days (p = .205). Mean patients' satisfaction scores were, respectively, 18.9 and 21.1, statistically significant (p = .022). Although tobacco use in moderate/large breasted patients can severely impair outcomes of breast reconstruction, the DMOP-SSM approach, compared to WP-SSM, allows smokers to benefit from SSM, but with statistically significant reduced skin flaps ischaemic complications, revision surgery, and better cosmetic outcomes.

Acute vascular effects of waterpipe smoking: Importance of physical activity and fitness status.

PubMed

Alomari, Mahmoud A; Khabour, Omar F; Alzoubi, Karem H; Shqair, Dana M; Stoner, Lee

2015-06-01

While new forms of tobacco, including waterpipe (WP) smoking, continue to gain popularity, limited literature has examined the vascular health consequences. The purpose of the current study was to examine: (i) the acute WP-induced changes in vascular function; (ii) whether acute changes in vascular function are modified by lifestyle behaviors (habitual physical activity, physical fitness). Fifty three (22.7 y, 36% F, 23.4 kg/m(2)) otherwise healthy WP smokers were recruited. Strain-gauge plethysmography was used to measure forearm blood flow, vascular resistance, venous capacitance, and venous outflow at rest and following occlusion. Habitual physical activity was determined using the Arabic version of short-form international physical activity questionnaire, while physical fitness was assessed using the 6 min walk test and handgrip strength. Partial correlations were used to examine the relationships between post-smoking vascular function and lifestyle behaviors, controlling for pre-smoking vascular measures. (i) WP had a small effect on forearm post-occlusion blood flow (d = -0.19), a moderate effect on venous outflow (d = 0.30), and a moderate effect on post-occlusion vascular resistance (d = 0.32). (ii) Total habitual physical activity strongly correlated with resting blood flow (r = 0.50) and moderately with vascular resistance (r = -0.40). Handgrip strength moderately correlated with venous capacitance (r = 0.30) and post-occlusion blood flow (r = 0.30), while 6 min walked distance moderately correlated with resting venous capacitance (r = 0.30). Waterpipe smoking is associated with immediate changes in vascular function, which are exacerbated in individuals with low habitual physical activity and physical fitness levels in young otherwise healthy individuals. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Gene molecular analysis and Adiponectin expression in professional Water Polo players.

PubMed

Nigro, Ersilia; Sangiorgio, Dino; Scudiero, Olga; Monaco, Maria Ludovica; Polito, Rita; Villone, Giovanni; Daniele, Aurora

2016-05-01

Metabolic Syndrome prevalence has reaching epidemic proportions worldwide. Adiponectin (Acrp30), and in particular its High Molecular Weight (HMW) oligomers, contributes to enhance insulin sensitivity and to reduce inflammation levels. Physical exercise improves body's biochemical balance and metabolism resulting effective in prevention of metabolic diseases. Whether improvement of metabolic features mediated by physical exercise is associated with changes in Acrp30 serum composition is not yet clarified. In the present study, we investigated total Acrp30 expression, its oligomeric status and genetic variants in adiponectin gene (ACDC) in twenty-two professional Water Polo (WP) Players and 40 age- and sex-matched controls. Anthropometric, metabolic parameters and total Acrp30 were assessed; Acrp30 oligomeric profile was characterized by Western blot as well as by FPLC analysis. ACDC gene was analyzed by direct-sequencing analysis. Significant elevated body mass index, aspartate aminotransferase and lactate dehydrogenase levels and, conversely, significantly lower concentrations of total and cholesterol low density lipoprotein were present in WP players. No significant difference was found in total Acrp30 and/or HMW oligomers. Interestingly, in WP players, a direct relationship between total Acrp30 and monocytes as well as an inverse relationship between total Acrp30 and AST levels were found. ACDC screening revealed previously described SNPs. In conclusion, our study confirms the long-term beneficial effects of high physical training on metabolism and suggests that they are not associated with Acrp30 and/or HMW oligomers changes. Moreover, the correlation of Acrp30 with monocytes in WP athletes could represent a mechanism by which Acrp30 participates in exercise-induced anti-inflammatory functions and/or cardiovascular health. Copyright © 2016 Elsevier Ltd. All rights reserved.

Production and characterization of monoclonal antibodies to wall-localized peroxidases from corn seedlings

NASA Technical Reports Server (NTRS)

Kim, S. H.; Terry, M. E.; Hoops, P.; Dauwalder, M.; Roux, S. J.

1988-01-01

A library of 22 hybridomas, which make antibodies to soluble wall antigens from the coleoptiles and primary leaves of etiolated corn (Zea mays L.) seedlings, was raised and cloned three times by limit dilution to assure monoclonal growth and stability. Two of these hybridomas made immunoglobulin G antibodies, designated mWP3 and mWP19, which both effectively immunoprecipitated peroxidase activity from crude and partially purified preparations of wall peroxidases. Direct peroxidase-binding assays revealed that both antibodies bound enzymes with peroxidase activity. As judged by immunoblot analyses, mWP3 recognized a Mr 98,000 wall peroxidase with an isoelectric point near 4.2, and mWP19 recognized a Mr 58,000 wall peroxidase. Immunogold localization studies showed both peroxidases are predominately in cell walls.

Evaluation of the effects of mulch on optimum sowing date and irrigation management of zero till wheat in central Punjab, India using APSIM.

PubMed

Balwinder-Singh; Humphreys, E; Gaydon, D S; Eberbach, P L

2016-10-01

Machinery for sowing wheat directly into rice residues has become more common in the rice-wheat systems of the north-west Indo-Gangetic Plains of South Asia, with increasing numbers of farmers now potentially able to access the benefits of residue retention. However, surface residue retention affects soil water and temperature dynamics, thus the optimum sowing date and irrigation management for a mulched crop may vary from those of a traditional non-mulched crop. Furthermore, the effects of sowing date and irrigation management are likely to vary with soil type and seasonal conditions. Therefore, a simulation study was conducted using the APSIM model and 40 years of weather data to evaluate the effects of mulch, sowing date and irrigation management and their interactions on wheat grain yield, irrigation requirement (I) and water productivity with respect to irrigation (WP I ) and evapotranspiration (WP ET ). The results suggest that the optimum wheat sowing date in central Punjab depends on both soil type and the presence or absence of mulch. On the sandy loam, with irrigation scheduled at 50% soil water deficit (SWD), the optimum sowing date was late October to early November for maximising yield, WP I and WP ET . On the clay loam, the optimum date was about one week later. The effect of mulch on yield varied with seasonal conditions and sowing date. With irrigation at 50% SWD, mulching of wheat sown at the optimum time increased average yield by up to 0.5 t ha -1 . The beneficial effect of mulch on yield increased to averages of 1.2-1.3 t ha -1 as sowing was advanced to 15 October. With irrigation at 50% SWD and 7 November sowing, mulch reduced the number of irrigations by one in almost 50% of years, a reduction of about 50 mm on the sandy loam and 60 mm on the clay loam. The reduction in irrigation amount was mainly due to reduced soil evaporation. Mulch reduced irrigation requirement by more as sowing was delayed, more so on the sandy loam than the clay loam soil. There was little effect of mulch on irrigation requirement for late October sowings. There were large trade-offs between irrigation input, yield, WP ET and WP I on the sandy loam with regard to the optimum irrigation schedule. Maximum yield occurred with very frequent irrigation (10-20% SWD) which also had the greatest irrigation input, while WP I was highest with least frequent irrigation (70% SWD), and WP ET was highest with irrigation at 40-50% SWD. This was the case with and without mulch. On the clay loam, the trade-offs were not so pronounced, as maximum yield was reached with irrigation at 50% SWD, with and without mulch. However, both WP ET and WP I were maximum and irrigation input least at the lowest irrigation frequency (70% SWD). On both soils, maximum yield, WP ET and WP I were higher with mulch, while irrigation input was slightly lower, but mulch had very little effect on the irrigation thresholds at which each parameter was maximised.

RAC1 GTP-ase signals Wnt-beta-catenin pathway mediated integrin-directed metastasis-associated tumor cell phenotypes in triple negative breast cancers.

PubMed

De, Pradip; Carlson, Jennifer H; Jepperson, Tyler; Willis, Scooter; Leyland-Jones, Brian; Dey, Nandini

2017-01-10

The acquisition of integrin-directed metastasis-associated (ID-MA) phenotypes by Triple-Negative Breast Cancer (TNBC) cells is caused by an upregulation of the Wnt-beta-catenin pathway (WP). We reported that WP is one of the salient genetic features of TNBC. RAC-GTPases, small G-proteins which transduce signals from cell surface proteins including integrins, have been implicated in tumorigenesis and metastasis by their role in essential cellular functions like motility. The collective percentage of alteration(s) in RAC1 in ER+ve BC was lower as compared to ER-ve BC (35% vs 57%) (brca/tcga/pub2015). High expression of RAC1 was associated with poor outcome for RFS with HR=1.48 [CI: 1.15-1.9] p=0.0019 in the Hungarian ER-veBC cohort. Here we examined how WP signals are transduced via RAC1 in the context of ID-MA phenotypes in TNBC. Using pharmacological agents (sulindac sulfide), genetic tools (beta-catenin siRNA), WP modulators (Wnt-C59, XAV939), RAC1 inhibitors (NSC23766, W56) and WP stimulations (LWnt3ACM, Wnt3A recombinant) in a panel of 6-7 TNBC cell lines, we studied fibronectin-directed (1) migration, (2) matrigel invasion, (3) RAC1 and Cdc42 activation, (4) actin dynamics (confocal microscopy) and (5) podia-parameters. An attenuation of WP, which (a) decreased cellular levels of beta-catenin, as well as its nuclear active-form, (b) decreased fibronectin-induced migration, (c) decreased invasion, (d) altered actin dynamics and (e) decreased podia-parameters was successful in blocking fibronectin-mediated RAC1/Cdc42 activity. Both Wnt-antagonists and RAC1 inhibitors blocked fibronectin-induced RAC1 activation and inhibited the fibronectin-induced ID-MA phenotypes following specific WP stimulation by LWnt3ACM as well as Wnt3A recombinant protein. To test a direct involvement of RAC1-activation in WP-mediated ID-MA phenotypes, we stimulated brain-metastasis specific MDA-MB231BR cells with LWnt3ACM. LWnt3ACM-stimulated fibronectin-directed migration was blocked by RAC1 inhibition in MDA-MB231BR cells. In the light of our previous report that WP upregulation causes ID-MA phenotypes in TNBC tumor cells, here we provide the first mechanism based evidence to demonstrate that WP upregulation signals ID-MA tumor cell phenotypes in a RAC1-GTPase dependent manner involving exchange-factors like TIAM1 and VAV2. Our study demonstrates for the first time that beta-catenin-RAC1 cascade signals integrin-directed metastasis-associated tumor cell phenotypes in TNBC.

Igneous sills record far-field and near-field stress interactions during volcano construction: Isle of Mull, Scotland

NASA Astrophysics Data System (ADS)

Stephens, T. L.; Walker, R. J.; Healy, D.; Bubeck, A.; England, R. W.; McCaffrey, K. J. W.

2017-11-01

Sill emplacement is typically associated with horizontally mechanically layered host rocks in a near-hydrostatic far-field stress state, where contrasting mechanical properties across the layers promote transitions from dykes, or inclined sheets, to sills. We used detailed field observations from the Loch Scridain Sill Complex (Isle of Mull, UK), and mechanical models to show that layering is not always the dominant control on sill emplacement. The studied sills have consistently shallow dips (1°-25°) and cut vertically bedded and foliated metamorphic basement rocks, and horizontally bedded cover sedimentary rocks and lavas. Horizontal and shallowly-dipping fractures in the host rock were intruded with vertical opening in all cases, whilst steeply-dipping discontinuities within the sequence (i.e. vertical fractures and foliation in the basement, and vertical polygonal joints in the lavas) were not intruded during sill emplacement. Mechanical models of slip tendency, dilation tendency, and fracture susceptibility for local and overall sill geometry data, support a radial horizontal compression during sill emplacement. Our models show that dykes and sills across Mull were emplaced during NW-SE horizontal shortening, related to a far-field tectonic stress state. The dykes generally accommodated phases of NE-SW horizontal tectonic extension, whereas the sills record the superposition of the far-field stress with a near-field stress state, imposed by emplacement of the Mull Central Volcano. We show that through detailed geometric characterisation coupled with mechanical modelling, sills may be used as an indication of fluctuations in the paleostress state.

STAT3 inhibitor WP1066 as a novel therapeutic agent for bCCI neuropathic pain rats.

PubMed

Xue, Zhao-Jing; Shen, Le; Wang, Zhi-Yao; Hui, Shang-Yi; Huang, Yu-Guang; Ma, Chao

2014-10-02

Activation of signal transducer and activator of transcription-3 (STAT3) is suggested to be critically involved in the development of chronic pain, but the complex regulation of STAT3-dependent pathway and the functional significance of inhibiting this pathway during the development of neuropathic pain remain elusive. To evaluate the contribution of the JAK2/STAT3 pathway to neuropathic pain and the potentiality of this pathway as a novel therapeutic target, we examined the effects of the STAT3 inhibitor WP1066 by intrathecal administration in a rat model of bilateral chronic constriction injury (bCCI). The pain behavior tests were performed before the surgery and on postoperative day 3, 7, 14 and 21. L4-L6 dorsal spinal cord were harvested at each time point. Both RT-PCR and Western blot were performed to evaluate the activation of JAK2/STAT3 pathway. To observe the influence of WP1066 on neuropathic pain and its molecular mechanism, WP1066 (10 μl, 10 mmol/L in DMSO) or the same capacity of DMSO as the control were applied through the intrathecal tube on the day before bCCI surgery, and on the postoperative day 3 and 5. Behavioral tests were performed to observe the therapeutic effect on mechanical, thermal and cold hyperalgesia. L4-L6 dorsal spinal cord was harvested on postoperative day fourteen, followed by RT-PCR and Western blot evaluation of the JAK2/STAT3 pathway activation. The mechanical, thermal and cold hyperalgesia of the bCCI rats were significantly decreased when compared with the Sham or the Naïve group at each postoperative time point (P<0.05). JAK2 mRNA and STAT3 mRNA were significantly increased in the bCCI rats, accompanied by SOCS3 mRNA with a similar tendency. Western blot analysis showed that JAK2 and phosphorylated STAT3 increased significantly since 3 days after bCCI. JAK2 peaked on postoperative day 14 while phosphorylated STAT3 peaked on postoperative day 7 and gradually decreased thereafter and SOCS3׳s peak level on postoperative day 3. When WP1066 were administered intrathecally, the pain behaviors of the bCCI rats were significantly improved (P<0.05). WP1066 also inhibited the mRNA level of JAK2, STAT3 and SOCS3 in bCCI rats significantly, together with the protein level of JAK2, phosphorylated STAT3 and SOCS3 on postoperative day 14 as well. Our results found that the JAK2/STAT3 pathway in the spinal cord dorsal horn was significantly activated in the bCCI neuropathic pain rats. WP1066, which inhibited the STAT3 pathway specifically, could partially alleviate the pain behavior of the bCCI rats. So it may serve as a novel therapeutic strategy against neuropathic pain. Copyright © 2014 Elsevier B.V. All rights reserved.

The Establishment of a Management Information Systems Research Center at the Naval Postgraduate School

DTIC Science & Technology

1989-09-01

Project WP 88-03 GDSS Technology in Practice: A Study D. Straub R. Beauclair WP 88-04 Interaction Analysis in GDSS Research: I. Zigurs Description of an...03 GDSS Technology in Practice: A Study (D. Straub and R. Beauclair ) 4. WP 88-04 Interaction Analysis in GDSS Research: Description of an Experience...Implementing an Information Architecture," Data Base, forthcoming. 25 Straub, D. W. and R. A. Beauclair . "A New Dimension to Decision Support

JCOMM Expert Team on Sea Ice (ETSI), Third Session Steering Group for the Global Digital Sea Ice Data Bank (GDSIDB) Eleventh Session

DTIC Science & Technology

2007-03-01

SHIPPING ASSESSMENT (AMSA) - TERMS OF REFERENCE BACKGROUND In November 2004, the Arctic Council released the Arctic Climate Impact Assesment (ACIA...studied. Project Plan: In an effort to assess Arctic marine activity and the resulting social, economic, and environmental impacts , the AMSA project is...Economics) WP 4 - Environmental Impact of Today’s Arctic Marine Activity WP 5 - Environmental Impact of Arctic Marine Activity in 2020 and 2050 WP 6

Estimating the Life Cycle Cost of Space Systems

NASA Technical Reports Server (NTRS)

Jones, Harry W.

2015-01-01

A space system's Life Cycle Cost (LCC) includes design and development, launch and emplacement, and operations and maintenance. Each of these cost factors is usually estimated separately. NASA uses three different parametric models for the design and development cost of crewed space systems; the commercial PRICE-H space hardware cost model, the NASA-Air Force Cost Model (NAFCOM), and the Advanced Missions Cost Model (AMCM). System mass is an important parameter in all three models. System mass also determines the launch and emplacement cost, which directly depends on the cost per kilogram to launch mass to Low Earth Orbit (LEO). The launch and emplacement cost is the cost to launch to LEO the system itself and also the rockets, propellant, and lander needed to emplace it. The ratio of the total launch mass to payload mass depends on the mission scenario and destination. The operations and maintenance costs include any material and spares provided, the ground control crew, and sustaining engineering. The Mission Operations Cost Model (MOCM) estimates these costs as a percentage of the system development cost per year.

Promotion of immune and glycaemic functions in streptozotocin-induced diabetic rats treated with un-denatured camel milk whey proteins.

PubMed

Ebaid, Hossam

2014-01-01

T cell mediated autoimmune diabetes is characterized by immune cell infiltration of pancreatic islets and destruction of insulin-producing β-cells. This study was designed to assess the effect of whey proteins (WP) on the responsiveness of lymphocytes in rats after four months of Streptozotocin (STZ)-induced Type 1 diabetes (T1D). A diabetic group was supplemented with WP daily for five weeks at a dose of 100 mg/kg. Ribonucleic acid (RNA) was extracted from stimulated lymphocytes in order to analyse gene expressions using real time PCR and RT-PCR. PCR results were confirmed with ELISA. The proliferation capacity of lymphocytes and their homing to the spleen were studied. Antigen-activated lymphocytes showed that diabetes impaired the mRNA expression of the protein kinase B (Akt1), Cdc42, and the co-stimulatory molecule, CD28, which are important for cell survival, actin polymerization and T cell activation, respectively. Accordingly, proliferation of lymphocytes was found to be suppressed in diabetic rats, both in vivo and in vitro. WP was found to restore Akt1, Cdc42 and CD28 mRNA expression during diabetes to normal levels. WP, therefore, served to activate the proliferation of B lymphocytes in diabetic rats both in vivo and in vitro. Although WP was found to up-regulate mRNA expression of both interleukin (IL)-2 and interferon gamma (IFN-γ), it suppressed the proliferation activity of almost all T cell subsets. This was confirmed by WP normalizing the structure and function of ß cells. Meanwhile, WP was found to down regulate the mRNA expression of Tumor necrosis factor-alpha (TNF-α) and its programmed cell death-receptor (Fas). Taken together, the results of this study provide evidence for the potential impact of WP in the treatment of immune impairment in T1D, suggesting that it serves to reverse autoimmunity by suppressing autoreactive T cells and down regulating TNF-α and Fas, resulting in improved pancreatic ß cell structure and function.

Acute and second-meal effects of peanuts on glycaemic response and appetite in obese women with high type 2 diabetes risk: a randomised cross-over clinical trial.

PubMed

Reis, Caio E G; Ribeiro, Daniela N; Costa, Neuza M B; Bressan, Josefina; Alfenas, Rita C G; Mattes, Richard D

2013-06-01

Nut consumption is associated with a reduced risk of type 2 diabetes mellitus (T2DM). The aim of the present study was to assess the effects of adding peanuts (whole or peanut butter) on first (0-240 min)- and second (240-490 min)-meal glucose metabolism and selected gut satiety hormone responses, appetite ratings and food intake in obese women with high T2DM risk. A group of fifteen women participated in a randomised cross-over clinical trial in which 42·5 g of whole peanuts without skins (WP), peanut butter (PB) or no peanuts (control) were added to a 75 g available carbohydrate-matched breakfast meal. Postprandial concentrations (0-490 min) of glucose, insulin, NEFA, glucagon-like peptide-1 (GLP-1), peptide YY (PYY), cholecystokinin (CCK), appetitive sensations and food intake were assessed after breakfast treatments and a standard lunch. Postprandial NEFA incremental AUC (IAUC) (0-240 min) and glucose IAUC (240-490 min) responses were lower for the PB breakfast compared with the control breakfast. Insulin concentrations were higher at 120 and 370 min after the PB consumption than after the control consumption. Desire-to-eat ratings were lower, while PYY, GLP-1 and CCK concentrations were higher after the PB intake compared with the control intake. WP led to similar but non-significant effects. The addition of PB to breakfast moderated postprandial glucose and NEFA concentrations, enhanced gut satiety hormone secretion and reduced the desire to eat. The greater bioaccessibility of the lipid component in PB is probably responsible for the observed incremental post-ingestive responses between the nut forms. Inclusion of PB, and probably WP, to breakfast may help to moderate glucose concentrations and appetite in obese women.

Effects of adding bulking agents on the biodrying of kitchen waste and the odor emissions produced.

PubMed

Yuan, Jing; Li, Yun; Zhang, Hongyu; Zhang, Difang; Chadwick, David; Li, Guoxue; Wang, Guoying; Chi, Menghao; Yang, Fan

2018-05-01

The effects of adding a bulking agent on the performance and odor emissions (ammonia and eight sulfur-containing odorous compounds) when biodrying kitchen waste were investigated. Three treatments were considered: the addition of either cornstalks (CS) or wood peat (WP) to kitchen waste as a bulking agent before biodrying, and a control treatment (CK). The water-removal rates for CK, CS, and WP treatments were 0.35, 0.56, and 0.43kg/kg, respectively. Addition of bulking agents to kitchen waste produced less leachate, higher moisture-removal rates, and lower consumption of volatile solids. The CS treatment had the highest biodrying index (4.07), and those for the WP and CK treatments were 3.67 and 1.97, respectively. Adding cornstalks or wood peat decreased NH 3 emissions by 55.8% and 71.7%, respectively. Total sulfur losses were 3.6%-21.6% after 21days biodrying, and H 2 S and Me 2 SS were the main (>95%) sulfur compounds released. The smallest amounts of sulfur-containing odorous compounds were emitted when cornstalks were added, and adding cornstalks and wood peat decreased total sulfur losses by 50.6%-64.8%. Copyright © 2017. Published by Elsevier B.V.

Effects of brisk walking on static and dynamic balance, locomotion, body composition, and aerobic capacity in ageing healthy active men.

PubMed

Paillard, T; Lafont, C; Costes-Salon, M C; Rivière, D; Dupui, P

2004-10-01

This work analyses the short-term physiological and neurophysiological effects of a brisk walking programme in ageing, healthy, active men. Twenty-one men 63 to 72 years of age were recruited and separated into 2 groups. One group performed a walking programme (WP) (n = 11) and another served as control (C) group (n = 10). The walking programme lasted for twelve weeks and included five sessions per week. Several parameters were assessed before and after the programme for the WP group. The same tests were performed (separated by twelve weeks) in group C. During each assessment, the subjects were put through static and dynamic balance tests, spatio-temporal gait analysis, body composition measurements and determination of aerobic capacity and bone mineral density. The statistic analysis showed a significant improvement in dynamic balance performance, especially in lateral sway when the subjects kept their eyes open, an increase of VO(2) max and loss of fat mass in the WP group. However, no alterations appeared in spatiotemporal gait characteristics, static balance performance, lean mass or bone mineral density (total body and hip). According to these results, this walking programme may have positive effects on preventing ageing subjects from falling.

Tourette Association Chapters

MedlinePlus

... 1 [read] => 1 [upload_files] => 1 [chapter] => 1 ) [filter] => ) Alaska Chapter View WP_User Object ( [data] => stdClass ... 1 [read] => 1 [upload_files] => 1 [chapter] => 1 ) [filter] => ) Arizona Chapter View WP_User Object ( [data] => stdClass ...

Biochar can be a suitable replacement for Sphagnum peat in nursery production of Pinus ponderosa seedlings

Treesearch

R. Kasten Dumroese; Jeremiah R. Pinto; Juha Heiskanen; Arja Tervahauta; Katherine G. McBurney; Deborah S. Page-Dumroese; Karl Englund

2018-01-01

We replaced a control peat medium with up to 75% biochar on a volumetric basis in three different forms (powder, BC; pyrolyzed softwood pellets, PP; composite wood-biochar pellets, WP), and under two supplies of nitrogen fertilizer (20 or 80 mg N) subsequently grew seedlings with a comparable morphology to the control. Using gravimetric methods to determine irrigation...

Advanced, Adaptive, Modular, Distributed, Generic Universal FADEC Framework for Intelligent Propulsion Control Systems (Preprint)

DTIC Science & Technology

2007-09-01

AFRL-RZ-WP-TP-2008-2044 ADVANCED, ADAPTIVE, MODULAR, DISTRIBUTED, GENERIC UNIVERSAL FADEC FRAMEWORK FOR INTELLIGENT PROPULSION CONTROL...GRANT NUMBER 4. TITLE AND SUBTITLE ADVANCED, ADAPTIVE, MODULAR, DISTRIBUTED, GENERIC UNIVERSAL FADEC FRAMEWORK FOR INTELLIGENT PROPULSION... FADEC is unique and expensive to develop, produce, maintain, and upgrade for its particular application. Each FADEC is a centralized system, with a

Extended Range Intercept Technology

DTIC Science & Technology

1991-09-01

particle size other than Freon class fluids. The requirements for a solvent used in grinding ammonium perchlorate to a one micron particle size are high...demonstrate a preprototype missile and launch control systems technology for tactical missile defense applications, including performance ...these two flights would be to verify flight performance and stability of the basic air frame and control system design (LTV Missiles and 1 -2 wp«-2a

EPOS-IP WP10: services and data provision for the GNSS community

NASA Astrophysics Data System (ADS)

Fernandes, Rui

2016-04-01

The EPOS-IP WP10 - "GNSS Data & Products" is the Working Package of the EPOS-IP project in charge of implementing the necessary services in order that the geo-sciences community can access the existing Pan-European Geodetic Infrastructures. The WP10 is formed by representatives of the participating institutions (10) but it is also open to the entire geodetic community. In fact, WP10 also includes members from other institutions/countries that formally are not participating in the EPOS-IP. During the EPOS-IP project, the geodetic component of EPOS (WP10) is dealing essentially with Research Infrastructures focused on continuous operating GNSS (cGNSS). The option of concentrating the efforts on the presently most generalized geodetic tool supporting research on Solid Earth was decided in order to optimize the existing resources. Furthermore, although the focus is on Solid Earth applications, other research and technical applications (e.g., reference frames, meteorology, space weather) can also benefit from the efforts of WP10 towards the optimization of the geodetic resources in Europe. We will present and discuss the plans for the implementation of the thematic and core services (TCS) for GNSS data within EPOS and the related business plan. We will focus on strategies towards the implementation of the best solutions that will permit to the end-users, and in particular geo-scientists, to access the geodetic data, derived solutions, and associated metadata using transparent and uniform processes. The collaboration with EUREF is also an essential component of the implementation plan.

Processing of probabilistic information in weight perception and motor prediction.

PubMed

Trampenau, Leif; van Eimeren, Thilo; Kuhtz-Buschbeck, Johann

2017-02-01

We studied the effects of probabilistic cues, i.e., of information of limited certainty, in the context of an action task (GL: grip-lift) and of a perceptual task (WP: weight perception). Normal subjects (n = 22) saw four different probabilistic visual cues, each of which announced the likely weight of an object. In the GL task, the object was grasped and lifted with a pinch grip, and the peak force rates indicated that the grip and load forces were scaled predictively according to the probabilistic information. The WP task provided the expected heaviness related to each probabilistic cue; the participants gradually adjusted the object's weight until its heaviness matched the expected weight for a given cue. Subjects were randomly assigned to two groups: one started with the GL task and the other one with the WP task. The four different probabilistic cues influenced weight adjustments in the WP task and peak force rates in the GL task in a similar manner. The interpretation and utilization of the probabilistic information was critically influenced by the initial task. Participants who started with the WP task classified the four probabilistic cues into four distinct categories and applied these categories to the subsequent GL task. On the other side, participants who started with the GL task applied three distinct categories to the four cues and retained this classification in the following WP task. The initial strategy, once established, determined the way how the probabilistic information was interpreted and implemented.

Can the GEOS CCM Simulate the Temperature Response to Warm Pool El Nino Events in the Antarctic Stratosphere?

NASA Technical Reports Server (NTRS)

Hurwitz, M. M.; Song, I.-S.; Oman, L. D.; Newman, P. A.; Molod, A. M.; Frith, S. M.; Nielsen, J. E.

2011-01-01

"Warm pool" (WP) El Nino events are characterized by positive sea surface temperature (SST) anomalies in the central equatorial Pacific. During austral spring, WP El Nino events are associated with an enhancement of convective activity in the South Pacific Convergence Zone, provoking a tropospheric planetary wave response and thus increasing planetary wave driving of the Southern Hemisphere stratosphere. These conditions lead to higher polar stratospheric temperatures and to a weaker polar jet during austral summer, as compared with neutral ENSO years. Furthermore, this response is sensitive to the phase of the quasi-biennial oscillation (QBO): a stronger warming is seen in WP El Nino events coincident with the easterly phase of the quasi-biennial oscillation (QBO) as compared with WP El Nino events coincident with a westerly or neutral QBO. The Goddard Earth Observing System (GEOS) chemistry-climate model (CCM) is used to further explore the atmospheric response to ENSO. Time-slice simulations are forced by composited SSTs from observed NP El Nino and neutral ENSO events. The modeled eddy heat flux, temperature and wind responses to WP El Nino events are compared with observations. A new gravity wave drag scheme has been implemented in the GEOS CCM, enabling the model to produce e realistic, internally generated QBO. By repeating the above time-slice simulations with this new model version, the sensitivity of the WP El Nino response to the phase of the quasi-biennial oscillation QBO is estimated.

Impact of TiO2 on the chemical and biological transformation of formulated chiral-metalaxyl in agricultural soils.

PubMed

Huang, Junxing; Zhang, Xu; Liang, Chuanzhou; Hu, Jun

2018-04-15

The impacts of TiO 2 on the chemical and biological transformation of racemic metalaxyl wettable powder (rac-metalaxyl WP) in agricultural soils, and soil microorganisms were investigated. Under simulated solar irradiation, TiO 2 highly promoted the transformation of rac-metalaxyl WP without changing the enantiomer fraction, with the promotion amplitude (60-1280%) being dependent on TiO 2 characteristics. TiO 2 characteristics showed different influence on the transformation of rac-metalaxyl WP in soils and aqueous solutions because their characteristics changed differently in soils. The impact of the mancozeb and other co-constituents on the transformation of rac-metalaxyl WP was smaller in soil media than in aqueous solution. Autoclave sterilization changed soil properties and subsequently weakened the promotion effects of TiO 2 on the chemical transformations of rac-metalaxyl WP to 0-233%. Microorganism biomass and bacterial community were not statistically significant changed by TiO 2 exposure regardless of rac-metalaxyl WP, suggesting that the promotional effects occurred mainly through chemical processes. The results also showed TiO 2 -soil interactions may be strengthened with TiO 2 (Degussa P25) aging time in soils, which decreased its promotion amplitude from 1060% (without aging) to 880% (aging for 20 days). Intermediate formed in soil biological transformation process was different from that in TiO 2 photocatalysis process. Copyright © 2018 Elsevier B.V. All rights reserved.

Potential of Kaolin-based Particle Film Barriers for Formosan Subterranean Termite (Isoptera: Rhinotermitidae) Control

USDA-ARS?s Scientific Manuscript database

Effects of three particle film products on Formosan subterranean termites, Coptotermes formosanus Shiraki, were evaluated in feeding, tunneling, and contact assays. The particle films, hydrophobic M96-018 and hydrophilic Surround and Surround WP are based on the inert clay mineral kaolin. In 2-week ...

Upcycling: converting waste plastics into paramagnetic, conducting, solid, pure carbon microspheres.

PubMed

Pol, Vilas Ganpat

2010-06-15

The recent tremendous increase in the volume of waste plastics (WP) will have a harmful environmental impact on the health of living beings. Hundreds of years are required to degrade WP in atmospheric conditions. Hence, in coming years, in addition to traditional recycling services, innovative "upcycling" processes are necessary. This article presents an environmentally benign, solvent-free autogenic process that converts various WP [low density polyethylene (LDPE), high density polyethylene (HDPE), polyethylene terephthalate (PET), polystyrene (PS), or their mixtures] into carbon microspheres (CMSs), an industrially significant, value-added product. The thermal dissociation of these individual or mixed WP in a closed reactor under autogenic pressure ( approximately 1000 psi) produced dry, pure powder of CMSs. In this paper, the optimization of process parameters such as the effect of mixing of WP with other materials, and the role of reaction temperature and time are reported. Employing advanced analytical techniques, the atomic structure, composition, and morphology of as-obtained CMSs were analyzed. The room-temperature paramagnetism in CMSs prepared from waste LDPE, HDPE, and PS was further studied by electron paramagnetic resonance (EPR). The conducting and paramagnetic nature of CMSs holds promise for their potential applications in toners, printers, paints, batteries, lubricants, and tires.

Walnut polyphenols prevent liver damage induced by carbon tetrachloride and d-galactosamine: hepatoprotective hydrolyzable tannins in the kernel pellicles of walnut.

PubMed

Shimoda, Hiroshi; Tanaka, Junji; Kikuchi, Mitsunori; Fukuda, Toshiyuji; Ito, Hideyuki; Hatano, Tsutomu; Yoshida, Takashi

2008-06-25

The polyphenol-rich fraction (WP, 45% polyphenol) prepared from the kernel pellicles of walnuts was assessed for its hepatoprotective effect in mice. A single oral administration of WP (200 mg/kg) significantly suppressed serum glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) elevation in liver injury induced by carbon tetrachloride (CCl 4), while it did not suppress d-galactosamine (GalN)-induced liver injury. In order to identify the active principles in WP, we examined individual constituents for the protective effect on cell damage induced by CCl 4 and d-GalN in primary cultured rat hepatocytes. WP was effective against both CCl 4- and d-GalN-induced hepatocyte damages. Among the constituents, only ellagitannins with a galloylated glucopyranose core, such as tellimagrandins I, II, and rugosin C, suppressed CCl 4-induced hepatocyte damage significantly. Most of the ellagitannins including tellimagrandin I and 2,3- O-hexahydroxydiphenoylglucose exhibited remarkable inhibitory effect against d-GalN-induced damage. Telliamgrandin I especially completely suppressed both CCl 4- and d-GalN-induced cell damage, and thus is likely the principal constituent for the hepatoprotective effect of WP.

A supramolecular photosensitizer system based on the host-guest complexation between water-soluble pillar[6]arene and methylene blue for durable photodynamic therapy.

PubMed

Yang, Kui; Wen, Jia; Chao, Shuang; Liu, Jing; Yang, Ke; Pei, Yuxin; Pei, Zhichao

2018-06-05

A supramolecular photosensitizer system WP6-MB was synthesized based on water-soluble pillar[6]arene and the photosensitizer methylene blue (MB) via host-guest interaction. MB can complex with WP6 directly with a high complex constant without further modification. In particular, WP6-MB can reduce the dark toxicity of MB remarkably. Furthermore, it can efficiently overcome photobleaching and extend the time for singlet oxygen production of MB upon light irradiation, which is significant for durable photodynamic therapy.

Combined effect of the East Atlantic/West Russia and Western Pacific teleconnections on the East Asian winter monsoon

NASA Astrophysics Data System (ADS)

Oh, Hyoeun; Jhun, Jong-Ghap; Ha, Kyung-Ja; Seo, Kyong-Hwan

2017-05-01

This study investigates the individual effects of the East Atlantic/West Russia (EATL/WRUS) and Western Pacific (WP) teleconnection patterns and their combined effect on the East Asian winter monsoon (EAWM). The contributions of the respective EATL/WRUS and WP teleconnection patterns to the EAWM are revealed by removing the dependence on the Arctic Oscillation (AO) and the El Niño-Southern Oscillation (ENSO) using a linear regression, which are named as N_EATL/WRUS and N_WP, respectively. This is because the EATL/WRUS (WP) is closely linked to the Arctic (tropics) region. A significant increase (decrease) in temperature over East Asia (EA) corresponding to a weak (strong) EAWM is associated with the N_EATL/WRUS and N_WP teleconnection patterns during the positive (negative) phases. In order to examine impacts of these two teleconnections on the EAWM, three types of effects are reconstructed on the basis of ± 0.5 standard deviation: 1) Combined effect, 2) N_EATL/WRUS effect, and 3) N_WP effect. The positive N_EATL/WRUS teleconnection induces to a weakened Siberian High and a shallow EA trough at the mid-troposphere through wave propagation, leading to the weak EAWM. During the positive N_WP pattern, warm air from the tropics flows toward the EA along western flank of an anomalous anticyclone over the North Pacific that is relevant to the meridional shift of the Aleutian Low. When the two mid-latitude teleconnections have the in-phase combination, the increase in temperature over EA appears to be more pronounced than the individual effects by transporting warm air from tropics via strong southeasterly wind anomalies induced by anomalous zonal pressure gradient between the Siberian High and Aleutian Low. Therefore, the impact of the mid-latitude teleconnections on the EAWM becomes robust and linearly superimposed, unlike a nonlinear in-phase combined effect of the AO and ENSO.

Impact of weight change during the course of concurrent chemoradiation therapy on outcomes in stage IIIB non-small cell lung cancer patients: retrospective analysis of 425 patients.

PubMed

Topkan, Erkan; Parlak, Cem; Selek, Ugur

2013-11-15

We retrospectively investigated the impact of weight change (WC) during concurrent chemoradiation therapy (C-CRT) on clinical outcomes of stage 3B non-small cell lung cancer (NSCLC) patients. A total of 425 patients treated with C-CRT were included. All patients received 60 to 66 Gy of thoracic radiation therapy concurrently with 1 to 3 cycles of platinum-based chemotherapy. Pre- and posttreatment weight measurements on first and last days of C-CRT were used for WC. Patients were divided into 2 groups: group 1=weight loss (WL); group 2=weight preservation/gain (WP) for comparative analyses. Following C-CRT, 252 patients (59.3%) experienced WL, while 89 patients (20.9%) and 84 patients (19.8%) showed WP or WG. At median 24.2 months of follow-up, 142 patients (33.4%) were alive (84 WP [48.6%] and 58 WL [23.0%]), and 58 (13.6%) of them were free of disease progression (41 [23.7%] for WP and 17 [6.7%] for WL). Median overall survival (OS), locoregional progression-free survival (LRPFS), progression-free survival (PFS), and distant metastases-free survival (DMFS) for the entire population were 22.8, 14.4, 10.6, and 11.7 months, respectively. Intergroup comparisons between WP and WL cohorts revealed significantly superior OS, LRPFS, PFS, and DMFS in WP patients (P<.05 for each). On multivariate analyses, only WL and advanced T stage were associated with poor prognosis (P<.05). Present results in 425 stage 3B NSCLC patients demonstrated that WL during C-CRT is strongly associated with inferior survival outcomes compared to WP. This emerging finding might be useful by forming an encouraging basis for future investigations in facilitating a way to improve the outcomes of these patients experiencing WL during C-CRT. Copyright © 2013 Elsevier Inc. All rights reserved.

Protective Effect of Contemporary Pertussis Vaccines: A Systematic Review and Meta-analysis.

PubMed

Fulton, T Roice; Phadke, Varun K; Orenstein, Walter A; Hinman, Alan R; Johnson, Wayne D; Omer, Saad B

2016-05-01

Acellular pertussis (aP) and whole-cell (wP) pertussis vaccines are presumed to have similar short-term (<3 years after completion of the primary series) efficacy. However, vaccine effect varies between individual pertussis vaccine formulations, and many originally studied formulations are now unavailable. An updated analysis of the short-term protective effect of pertussis vaccines limited to formulations currently on the market in developed countries is needed. We conducted a systematic review and meta-analysis of published studies that evaluated pertussis vaccine efficacy or effectiveness within 3 years after completion (>3 doses) of a primary series of a currently available aP or wP vaccine formulation. The primary outcome was based on the World Health Organization (WHO) clinical case definitions for pertussis. Study quality was assessed using the approach developed by the Child Health Epidemiology Research Group. We determined overall effect sizes using random-effects meta-analyses, stratified by vaccine (aP or wP) and study (efficacy or effectiveness) type. Meta-analysis of 2 aP vaccine efficacy studies (assessing the 3-component GlaxoSmithKline and 5-component Sanofi-Pasteur formulations) yielded an overall aP vaccine efficacy of 84% (95% confidence interval [CI], 81%-87%). Meta-analysis of 3 wP vaccine effectiveness studies (assessing the Behringwerke, Pasteur/Mérieux, and SmithKline Beecham formulations) yielded an overall wP vaccine effectiveness of 94% (95% CI, 88%-97%) (bothI(2)= 0%). Although all contemporary aP and wP formulations protect against pertussis disease, in this meta-analysis the point estimate for short-term protective effect against WHO-defined pertussis in young children was lower for currently available aP vaccines than wP vaccines. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

MED-SUV final strategic issues

NASA Astrophysics Data System (ADS)

Spampinato, Letizia; Puglisi, Giuseppe; Sangianantoni, Agata

2016-04-01

Aside the scientific, technical and financial aspects managed by the "Project Management" Work Package (WP1), the great challenge and more time consuming task of this WP has surely been the definition and application of some strategic guidelines crucial to trace the project right path to its final success and for the project outcome sustainability after month 36. In particular, given that one of the main objectives of MED-SUV is that to be compliant with the GEO initiative, particularly concerning the data sharing, great efforts have been made by WP1 at first to define the MED-SUV Data Policy Guidelines, and currently to make it suitable for the EU Supersites. At present, WP1 is also dealing with the exploitation of the achieved foreground among the project's participant and to define a Memorandum of Understanding to sustain the monitoring systems and e-infrastructure developed in the project framework. Whilst the Data Policy guidelines document was implemented in the first year of MED-SUV, WP1 is now focused on the last deliverable 'Strategic and Legal deliverables', which includes the remaining issues. To the aim, WP1 has strategically separated the Exploitation of Foreground document preparation from the Memorandum of Understanding definition. The Exploitation of Foreground process has regarded the identification of Foreground, the exploitable results, the purpose of such Foreground, the collection of information from either the scientific community of MED-SUV or industrial participants; to this aim WP1 circulated an ad hoc questionnaire to put together information on (the) every kind of MED-SUV outcome, on their owners, on the kind of ownership (single/joint), on the outcome exploitation, and on proposals for its sustainability. While the first information will allow us to prepare the final Exploitation Agreement among the project's participant, the information on the exploitation of the outcome and likely sustainability proposals will contribute to the definition of the project Memorandum of Understanding for the maintenance of the developed instrumentation and of the MED-SUV e-infrastructure following the project end.

Pertussis immunisation and control in England and Wales, 1957 to 2012: a historical review.

PubMed

Amirthalingam, G; Gupta, S; Campbell, H

2013-09-19

This review summarises the epidemiology and control of pertussis in England and Wales since the introduction of routine immunisation and considers the implications for future control. Routine infant immunisation with a whole-cell pertussis (wP) vaccine was introduced in 1957 and had a marked impact on the overall disease burden. Following a fall in vaccine coverage during the 1970s and 80s linked to a safety scare with wP vaccine, there was an extended period of high coverage and pertussis incidence fell dramatically. Incidence continued to decrease with the introduction of an acellular pertussis vaccine in the pre-school booster in November 2001 and in the primary United Kingdom (UK) schedule in September 2004 but has increased since July 2011. In response to a high rate of pertussis in infants, a temporary vaccination programme for pregnant women was introduced in October 2012. The key aim of the programme is to protect vulnerable infants from birth in the first months of life, before they can be fully protected by routine infant immunisation. A review of the UK adolescent immunisation programme is currently ongoing and the inclusion of a pertussis booster is being considered.

Antioxidant and antimicrobial properties of wine byproducts and their potential uses in the food industry.

PubMed

García-Lomillo, Javier; González-SanJosé, M Luisa; Del Pino-García, Raquel; Rivero-Pérez, M Dolores; Muñiz-Rodríguez, Pilar

2014-12-31

Wine pomace (WP) is one of the agricultural byproducts that has received most attention from food scientists due to the wide range of interesting compounds that remain after the winemaking process. Different powdered products rich in phenolic compounds, with interesting antioxidant and antimicrobial activities, were obtained from WP by applying processes that are both environmentally friendly and economically affordable for the food industry. The products obtained showed high global antioxidant activities (ABTS assay), successfully delayed the onset of lipid oxidation in the Rancimat test, and showed different antimicrobial properties. Products derived from seed-free WP showed bactericidal effects against total aerobic mesophilic bacteria (TAMB) and lactic acid bacteria (LAB) and inhibited Enterobacteriaceae growth completely. The product derived from whole WP presented bacteriostatic activity against the three microorganism groups tested, whereas the product obtained from grape seed promoted TAMB and LAB growth but delayed Enterobacteriaceae proliferation.

D. Alan Shewmon and the PCBE's White Paper on Brain Death: are brain-dead patients dead?

PubMed

Brugger, E Christian

2013-04-01

The December 2008 White Paper (WP) on "Brain Death" published by the President's Council on Bioethics (PCBE) reaffirmed its support for the traditional neurological criteria for human death. It spends considerable time explaining and critiquing what it takes to be the most challenging recent argument opposing the neurological criteria formulated by D. Alan Shewmon, a leading critic of the "whole brain death" standard. The purpose of this essay is to evaluate and critique the PCBE's argument. The essay begins with a brief background on the history of the neurological criteria in the United States and on the preparation of the 2008 WP. After introducing the WP's contents, the essay sets forth Shewmon's challenge to the traditional neurological criteria and the PCBE's reply to Shewmon. The essay concludes by critiquing the WP's novel justification for reaffirming the traditional conclusion, a justification the essay finds wanting.

Protection of Lactobacillus acidophilus NRRL-B 4495 under in vitro gastrointestinal conditions with whey protein/pullulan microcapsules.

PubMed

Çabuk, Burcu; Tellioğlu Harsa, Şebnem

2015-12-01

In this research, whey protein/pullulan (WP/pullulan) microcapsules were developed in order to assess its protective effect on the viability of Lactobacillus acidophilus NRRL-B 4495 under in vitro gastrointestinal conditions. Results demonstrated that WP/pullulan microencapsulated cells exhibited significantly (p ≤ 0.05) higher resistance to simulated gastric acid and bile salt. Pullulan incorporation into protein wall matrix resulted in improved survival as compared to free cells after 3 h incubation in simulated gastric solution. Moreover WP/pullulan microcapsules were found to release over 70% of encapsulated L. acidophilus NRRL-B 4495 cells within 1 h. The effect of encapsulation during refrigerated storage was also studied. Free bacteria exhibited 3.96 log reduction while, WP/pullulan encapsulated bacteria showed 1.64 log reduction after 4 weeks of storage. Copyright © 2015 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Physical barrier to reduce WP mortalities of foraging waterfowl

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pochop, P.A.; Cummings, J.L.; Yoder, C.A.

White phosphorus (WP) has been identified as the cause of mortality to certain species of water-fowl at Eagle River Flats, a tidal marsh in Alaska, used as an ordinance impact area by the US Army. A blend of calcium bentonite/organo clays, gravel, and binding polymers was tested for effectiveness as a barrier to reduce duck foraging and mortality. Following the application of the barrier to one of two contaminated ponds, the authors observed greater duck foraging and higher mortality in the untreated pond and no mortality in the treated pond after a year of tidal inundations and ice effects. Emergentmore » vegetation recovered within a year of treatment. WP levels in the barrier were less than the method limit of detection, indicating no migration of WP into the materials. Barrier thickness remained relatively stable over a period of 4 years, and vegetation was found to be important in stabilizing the barrier material.« less

Waterpipe dependence in university students and effect of normative beliefs: a cross-sectional study.

PubMed

Salameh, P; Salamé, J; Waked, M; Barbour, B; Zeidan, N; Baldi, I

2014-02-14

The objective of this study was to measure the correlates, including normative beliefs, associated with waterpipe (WP) and cigarette smoking prevalence and dependence. A cross-sectional study was carried out using a proportionate cluster sample of Lebanese students in 17 public and private universities. Of the 4900 distributed questionnaires, 3384 (69.1%) were returned to the field worker. All available students during break times were approached, with no exclusion criteria. sociodemographic variables, detailed active and passive smoking, in addition to items of the tobacco dependence scales were all evaluated. Correlates to WP smoking were studying in a private university (adjusted OR, aOR=1.50 (1.26 to 1.79); p<0.001) and ever smoking cigarettes (aOR=1.80(1.44 to 2.26); p<0.001); friends' and societal influence were found on smoking behaviour and dependence. Although the role of parents was not visible in decreasing the risk of smoking WP, their protective influence seemed more important on WP dependence (β=-1.09(-1.79 to -0.28); p<0.001), a behaviour that is considered more deleterious for health. Parents' and friends' disagreement with smoking had a protective effect on cigarette smoking and dependence (aOR<1; p<0.01), while thinking that idols and successful people smoke increased the risk of both cigarette smoking and dependence (aOR>1; p<0.01). In conclusion, WP smoking and dependence are influenced by parents' and friends' opinions, and idols' smoking status. Future research is necessary to further improve our understanding of motives for WP smoking and dependence.

Non-chromate Passivation for LHE ZnNi

DTIC Science & Technology

2017-03-01

control of coatings and processes. Development of an alternative methodology that is simple, repeatable, non -destructive, and capable of scanning across...FINAL REPORT Non -chromate Passivation for LHE ZnNi SERDP Project WP-2527 JANUARY 2017 Matt O’Keefe Missouri S&T...valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) 2. REPORT TYPE 3. DATES COVERED (From

Computational Study of Inlet Active Flow Control

DTIC Science & Technology

2007-05-01

AFRL-VA-WP-TR-2007-3077 COMPUTATIONAL STUDY OF INLET ACTIVE FLOW CONTROL Delivery Order 0005 Dr. Sonya T. Smith Howard University Department...NUMBER A0A2 5e. TASK NUMBER 6. AUTHOR(S) Dr. Sonya T. Smith ( Howard University ) Dr. Angela Scribben and Matthew Goettke (AFRL/VAAI) 5f...WORK UNIT NUMBER 0B 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION Howard University Department of Mechanical

METHOD-SPECIFIC PRECISION AND BIAS RELATIONSHIPS DEVELOPED FROM DATA SUBMITTED DURING USEPA WASTEWATER LABORATORY PERFORMANCE EVALUATION STUDIES

EPA Science Inventory

This paper documents the process used by the United States Environmental Protection Agency (USEPA) to estimate the mean and standard deviation of data reported by in-control wastewater laboratories during Water Pollution (WP) studies. This process is then applied to the data rep...

TVA's photovoltaic activities

NASA Astrophysics Data System (ADS)

Chinery, G. T.; Wood, J. M.

1985-08-01

This paper describes the Tennessee Valley Authority's (TVA) current photovoltaic (PV) activities. These include four roof-mounted 4 kWp residential arrays (which are also Southeast Residential Station field sites) and two 5-6 kWp commercial sites, all grid connected with no battery storage. Also included are approximately 30 kWp of non-grid-connected remote sites with storage (remote lighting, weather stations, etc.). Monitoring results from the two 'online' residential systems are presented. Finally, TVA's future PV plans are discussed, both with respect to interfacing with a multitude of residential and commercial cogenerators and with regard to possible TVA PV central station plans.

Circumvention of the multidrug-resistance protein (MRP-1) by an antitumor drug through specific inhibition of gene transcription in breast tumor cells.

PubMed

Mansilla, Sylvia; Rojas, Marta; Bataller, Marc; Priebe, Waldemar; Portugal, José

2007-04-01

Multidrug-resistance protein 1 (MRP-1) confers resistance to a number of clinically important chemotherapeutic agents. The promoter of the mrp-1 gene contains an Sp1-binding site, which we targeted using the antitumor bis-anthracycline WP631. When MCF-7/VP breast cancer cells, which overexpress MRP-1 protein, were incubated with WP631 the expression of the multidrug-resistance protein gene decreased. Conversely, doxorubicin did not alter mrp-1 gene expression. The inhibition of gene expression was followed by a decrease in the activity of the MRP-1 protein. The IC(75) for WP631 (drug concentration required to inhibit cell growth by 75%) circumvented the drug-efflux pump, without addition of resistant modifiers. After treatment with WP631, MCF-7/VP cells were committed to die after entering mitosis (mitotic catastrophe), while treatment with doxorubicin did not affect cell growth. This is the first report on an antitumor drug molecule inhibiting the mrp-1 gene directly, rather than being simply a poor substrate for the transporter-mediated efflux. However, both situations appeared to coexist, thereby a superior cytotoxic effect was attained. Ours results suggest that WP631 offers great potential for the clinical treatment of tumors displaying a multidrug-resistance phenotype.

Determination of dopamine hydrochloride by host-guest interaction based on water-soluble pillar[5]arene

NASA Astrophysics Data System (ADS)

Xiao, Xue-Dong; Shi, Lin; Guo, Li-Hui; Wang, Jun-Wen; Zhang, Xiang

2017-02-01

The supramolecular interaction between the water-soluble pillar[5]arene (WP[5]) as host and dopamine hydrochloride (DH) as guest was studied by spectrofluorometry. The fluorescence intensity of DH gradually decreased with increasing WP[5] concentration, and the possible interaction mechanism between WP[5] and DH was confirmed by 1H NMR, 2D NOESY, and molecular modelling. Based on significant DH fluorescence, a highly sensitive and selective method for DH determination was developed for the first time. The fluorescence intensity was measured at 312 nm, with excitation at 285 nm. The effects of pH, temperature, and reaction time on the fluorescence spectra of the WP[5]-DH complex were investigated. A linear relationship between fluorescence intensity and DH concentration in the range of 0.07-6.2 μg mL- 1 was obtained. The corresponding linear regression equation is ΔF = 25.76 C + 13.56 (where C denotes the concentration in μg mL- 1), with the limit of detection equal to 0.03 μg mL- 1 and the correlation coefficient equal to 0.9996. This method can be used for the determination of dopamine in injection and urine samples. In addition, the WP[5]-DH complex has potential applications in fluorescent sensing and pharmacokinetics studies of DH.

Upcycling : converting waste plastics into paramagnetic, conducting, solid, pure carbon microspheres.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pol, V.

2010-06-15

The recent tremendous increase in the volume of waste plastics (WP) will have a harmful environmental impact on the health of living beings. Hundreds of years are required to degrade WP in atmospheric conditions. Hence, in coming years, in addition to traditional recycling services, innovative 'upcycling' processes are necessary. This article presents an environmentally benign, solvent-free autogenic process that converts various WP [low density polyethylene (LDPE), high density polyethylene (HDPE), polyethylene terephthalate (PET), polystyrene (PS), or their mixtures] into carbon microspheres (CMSs), an industrially significant, value-added product. The thermal dissociation of these individual or mixed WP in a closed reactormore » under autogenic pressure (1000 psi) produced dry, pure powder of CMSs. In this paper, the optimization of process parameters such as the effect of mixing of WP with other materials, and the role of reaction temperature and time are reported. Employing advanced analytical techniques, the atomic structure, composition, and morphology of as-obtained CMSs were analyzed. The room-temperature paramagnetism in CMSs prepared from waste LDPE, HDPE, and PS was further studied by electron paramagnetic resonance (EPR). The conducting and paramagnetic nature of CMSs holds promise for their potential applications in toners, printers, paints, batteries, lubricants, and tires.« less

An efficient process for obtaining prebiotic oligosaccharides derived from lactulose using isomerized and purified whey permeate.

PubMed

Sabater, Carlos; Olano, Agustín; Prodanov, Marin; Montilla, Antonia; Corzo, Nieves

2017-12-01

One of the most promising uses of whey permeate (WP) is the synthesis of prebiotic oligosaccharides. Herein, commercial WP was submitted to chemical isomerization catalysed by sodium borate at an alkaline pH and subsequent purification using anion-exchange resins to remove boron. Subsequently, purified mixtures were used to synthesize prebiotic oligosaccharides using β-galactosidase from Bacillus circulans. Isomerization of concentrated WP (200 g L -1 lactose) gave rise to levels of lactulose up to 155.5 g L -1 after 30 min of reaction (molar ratio of boron/lactose, 1/1; pH 12; 70 °C). Boron was removed from the isomerized WP (IWP) using the combination of a strong acid (IR-120, H + ) and a weak base (IRA-743) anion-exchange resins, reducing its level to <1 ppm, without loss of lactulose. During the transglycosylation reaction of purified IWP (lactose/lactulose ratio, 1/2.4) maximum content of prebiotic compounds was achieved, i.e. 690 g kg -1 WP after 3 h of reaction. This study shows that combined chemical-enzymatic reactions together with the purification of IWP results in an efficient synthesis of prebiotic oligosaccharides. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

Easterly denitrification signal and nitrogen fixation feedback documented in the western Pacific sediments

NASA Astrophysics Data System (ADS)

Jia, Guodong; Li, Zhiyang

2011-12-01

A sedimentary δ15N record in the equatorial western Pacific (WP) shows glacial-interglacial variability from 6.2 to 11.2‰ during the last two climatic cycles, similar to the denitrification record in the eastern tropical Pacific (ETP). Contrastively, a record in the South China Sea (SCS) exhibits less changes from 4.4 to 6.4‰ and is quite alike previously published results in marginal seas in the WP. By ruling out several possible causes for the δ15N variability, the δ15N record in the equatorial WP is interpreted as the source nitrate δ15N signals advected from the ETP. Comparison of several δ15N records for the last 25 ka distributed in the WP brings out a pattern of northward decrease in δ15N values and variability from the equator to off Mindano and then to marginal seas, supposed to be caused by the northward increase of local N2 fixation. Therefore, the less glacial-interglacial changes in some δ15N records in the WP could imply that the glacial decrease in subsurface δ15N due to less denitrification in source waters from the ETP would have been isotopically compensated by a synchronous decrease in local N2 fixation.

Rapid non-invasive quality control of semi-finished products for the food industry by direct injection mass spectrometry headspace analysis: the case of milk powder, whey powder and anhydrous milk fat.

PubMed

Makhoul, Salim; Yener, Sine; Khomenko, Iuliia; Capozzi, Vittorio; Cappellin, Luca; Aprea, Eugenio; Scampicchio, Matteo; Gasperi, Flavia; Biasioli, Franco

2016-09-01

In this study, we demonstrated the suitability of direct injection mass spectrometry headspace analysis for rapid non-invasive quality control of semi-finished dairy ingredients, such as skim milk powder (SMP), whole milk powder (WMP), whey powder (WP) and anhydrous milk fat (AMF), which are widely used as ingredients in the food industry. In this work, for the first time, we applied proton transfer reaction-mass spectrometry (PTR-MS) with a time-of-flight (ToF) analyzer for the rapid and non-invasive analysis of volatile compounds in different samples of SMP, WMP, WP and AMF. We selected different dairy ingredients in various concrete situations (e.g. same producer and different expiration times, different producers and same days of storage, different producers) based on their sensory evaluation. PTR-ToF-MS allowed the separation and characterization of different samples based on the volatile organic compound (VOC) profiles. Statistically significant differences in VOC content were generally coherent with differences in sensory evaluation, particularly for SMP, WMP and WP. The good separation of SMP samples from WMP samples suggested the possible application of PTR-ToF-MS to detect possible cases of adulteration of dairy ingredients for the food industry. Our findings demonstrate the efficient and rapid differentiation of dairy ingredients on the basis of the released VOCs via PTR-ToF-MS analysis and suggest this method as a versatile tool (1) for the facilitation/optimization of the selection of dairy ingredients in the food industry and (2) and for the prompt innovation in the production of dairy ingredients. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Effects of Resistive Vibration Exercise Combined with Whey Protein and KHCO3 on Bone Tturnover Markers in Head-down Tilt Bed Rest (MTBR-MNX Study)

NASA Technical Reports Server (NTRS)

Graf, Sonja; Baecker, Natalie; Buehlmeier, Judith; Fischer, Annelie; Smith, Scott M.; Heer, Martina

2014-01-01

High protein intake further increases bone resorption markers in head-down tilt bed rest (HDBR), most likely induced by low-grade metabolic acidosis. Adding an alkaline salt to a diet with high protein content prevents this additional rise of bone resorption markers in HDBR. In addition, high protein intake, specifically whey protein, increases muscle protein synthesis and improves glucose tolerance, which both are affected by HDBR. Resistive vibration exercise (RVE) training counteracts the inactivity-induced bone resorption during HDBR. To test the hypothesis that WP plus alkaline salt (KHCO3) together with RVE during HDBR will improve bone turnover markers, we conducted a randomized, three-campaign crossover design study with 12 healthy, moderately fit male subjects (age 34+/-8 y, body mass [BM] 70 +/- 8 kg). All study campaigns consisted of a 7-d ambulatory period, 21days of -6 deg. head-down tilt bed rest (HDBR), and a 6-d recovery period. Diet was standardized and identical across phases. In the control (CON) campaign, subjects received no supplement or RVE. In the intervention campaigns, subjects received either RVE alone or combined with WP and KHCO3 (NEX). WP was applied in 3 doses per day of 0.6 g WP/kg BM together with 6 doses of 15 mmol KHCO3 per day. Eleven subjects completed the RVE and CON campaign, 8 subjects completed all three campaigns. On day 21 of HDBR excretion of the bone resorption marker C-telopeptide (CTX) was 80+/-28% (p<0.001) higher than baseline, serum calcium concentrations increased by 12 +/- 29% (p<0.001) and serum osteocalcin concentrations decreased by 6+/-12% (p=0.001). Urinary CTX excretion was 11+/- 25% (p=0.02) lower on day 21 of HDBR in the RVE- and tended to decrease by 3+/- 22% (p=0.06) in the NEX campaign compared to CON. Urinary calcium excretion was higher on day 21 in HDBR in the RVE and NEX (24+/- 43% p=0.01; 25+/- 37% p=0.03) compared to the CON campaign. We conclude that combination of RVE with WP/KHCO3 was not superior to RVE alone in any of these results.

Seasonal influence over serum and urine metabolic markers in submariners during prolonged patrols

PubMed Central

Holy, Xavier; Bégot, Laurent; Renault, Sylvie; Butigieg, Xavier; André, Catherine; Bonneau, Dominique; Savourey, Gustave; Collombet, Jean-Marc

2015-01-01

Within the framework of earlier publications, we have consistently dedicated our investigations to eliciting the effects of both seasonal vitamin D deficiency and submarine-induced hypercapnia on serum parameters for acid–base balance and bone metabolism in submariners over a 2-month winter (WP) or summer (SP) patrols. The latest findings reported herein, contribute further evidence with regard to overall physiological regulations in the same submariner populations that underwent past scrutiny. Hence, urine and blood samples were collected in WP and SP submariners at control prepatrol time as well as on submarine patrol days 20, 41, and 58. Several urine and serum metabolic markers were quantified, namely, deoxypyridinoline (DPD), lactate, albumin, creatinine, nonesterified fatty acids (NEFA), and ionized sodium (Na+) or potassium (K+), with a view to assessing bone, muscle, liver, or kidney metabolisms. We evidenced bone metabolism alteration (urine DPD, calcium, and phosphorus) previously recorded in submarine crewmembers under prolonged patrols. We also highlighted transitory modifications in liver metabolism (serum albumin) occurring within the first 20 days of submersion. We further evidenced changes in submariners’ renal physiology (serum creatinine) throughout the entire patrol time span. Measurements of ionic homeostasis (serum Na+ and K+) displayed potential seasonal impact over active ionic pumps in submariners. Finally, there is some evidence that submersion provides beneficial conditions prone to fend off seasonal lactic acidosis (serum lactate) detected in WP submariners. PMID:26265754

Development of a Finite State Machine for a Small Unmanned Aircraft System Using Experimental Design

DTIC Science & Technology

2015-03-26

54  Appendix B: Storyboard ....................................................................................................56  Bibliography...Script.ChangeParam(’WP_RADIUS’,90) Script.ChangeParam(’WP_LOITER_RAD’,90) print ’End Script’ 56 Appendix B: Storyboard 57

Relationships between type of pain and work participation in people with long-standing spinal cord injury: results from a cross-sectional study.

PubMed

Roels, Ellen H; Reneman, Michiel F; Stolwijk-Swuste, Janneke; van Laake-Geelen, Charlotte C; de Groot, Sonja; Adriaansen, Jacinthe J E; Post, Marcel W M

2018-05-01

Multicentre, cross-sectional study. To describe the relationships between the presence of (different types of) pain and participation in paid work in people with long-standing spinal cord injury (SCI). Furthermore, the associations of pain-related work limitations, age, gender, relationship, education, lesion level, and time since injury (TSI) with work participation (WP) were investigated. The Netherlands. Individuals (n = 265) with SCI for ≥ 10 years were included. Data were collected through a structured consultation with a rehabilitation physician and self-report questionnaire. Descriptive statistics and logistic regression analysis were performed. Median age of participants was 47.9 years, median time since injury was 22 years, 73% were male, 69% had complete SCI and 59% had paraplegia, 50% had paid work, 63% reported musculoskeletal pain, 49% reported neuropathic pain, and 31% reported other pain. Self-reported pain-related work limitations were significantly (V = 0.26 and V = 0.27) related to WP. In bivariable logistic regression analyses, no statistically significant relationships between type of pain and WP were observed. Younger age (OR=0.96), male gender (OR=0.52), a stable relationship (OR = 1.70), and shorter time since SCI (OR = 0.97) were significantly associated with a higher chance of being employed. Multivariable analysis confirmed these findings and in addition showed a higher level of education to be positively related with WP. Age, gender, relationship, education, TSI and self-reported work limitations showed a relationship with WP. Different types of pain were unrelated to WP. Fonds NutsOHRA through the Dutch Organization for Health Research and Development (ZonMw), Project number 89000006.

Effects of dry-land vs. in-water specific strength training on professional male water polo players' performance.

PubMed

de Villarreal, Eduardo Sáez; Suarez-Arrones, Luis; Requena, Bernardo; Haff, G Gregory; Ramos-Veliz, Rafael

2014-11-01

We compared the effects of 6-week dry-land and in-water specific strength training combined with a water polo (WP) program on 7 sport-specific performance parameters. Nineteen professional players were randomly assigned to 2 groups: in-water strength group (WSG) (in-water training only) and dry-land strength group (LSG). The program included 3 weekly strength training sessions and 5 days of WP training per week for 6 weeks during the preseason. Ten-meter T-agility test, 20-m maximal sprint swim, maximal dynamic strength (1 repetition maximum), bench press (BP) and full squat (FS), in-water boost, countermovement jump (CMJ), and WP throwing speed were measured. Significant improvements (p ≤ 0.05) were found in the experimental groups in some variables: CMJ in the LSG and WSG (2.35 cm, 9.07%, effect size [ES] = 0.89; and 2.6 cm, 7.6%, ES = 0.83, respectively), in-water boost increased in the WSG group (4.1 cm; 11.48%; ES = 0.70), and FS and BP increased (p ≤ 0.05) only in the LSG group (12.1 kg; 11.27%; ES = 1.15 and 8.3 kg; 9.55%; ES = 1.30, respectively). There was a decrease of performance in agility test (-0.55 seconds; 5.60%; ES = 0.74). Both dry-land and in-water specific strength training and high-intensity training in these male WP players produced medial to large effects on most WP-specific performance parameters. Therefore, we propose modifications to current training methodology for WP players in preseason to include both the training programs (dry-land and in-water specific strength training and high-intensity training) for athlete preparation in this sport.

The role of reactive oxygen species in WP 631-induced death of human ovarian cancer cells: a comparison with the effect of doxorubicin.

PubMed

Rogalska, Aneta; Gajek, Arkadiusz; Szwed, Marzena; Jóźwiak, Zofia; Marczak, Agnieszka

2011-12-01

In the present study, we investigated the anticancer activity of WP 631, a new anthracycline analog, in weakly doxorubicin-resistant SKOV-3 ovarian cancer cells. We studied the time-course of apoptotic and necrotic events: the production of reactive oxygen species (ROS) and changes in the mitochondrial membrane potential in human ovarian cancer cells exposed to WP 631 in the presence and absence of an antioxidant, N-acetylcysteine (NAC). The effect of WP 631 was compared with the activity of doxorubicin (DOX), the best known first-generation anthracycline. Cytotoxic activity was determined by the MTT assay. The morphological changes characteristic of apoptosis and necrosis in drug-treated cells were analyzed by double staining with Hoechst 33258 and propidium iodide (PI) using fluorescence microscopy. The production of reactive oxygen species and changes in mitochondrial membrane potential were studied using specific fluorescence probes: DCFH2-DA and JC-1, respectively. The experiments showed that WP 631 was three times more cytotoxic than DOX in the tested cell line. It was found that the new anthracycline analog induced mainly apoptosis and, marginally, necrosis. Apoptotic cell death was associated with morphological changes and a decrease in mitochondrial membrane potential. In comparison to DOX, the novel bisanthracycline induced a significantly higher level of ROS and a greater drop in the membrane potential. The results provide direct evidence that the novel anthracycline WP 631 is considerably more cytotoxic to human SKOV-3 ovarian cancer cells than doxorubicin. The drug can produce ROS, which are immediately involved in the induction of apoptotic cell death. Copyright © 2011 Elsevier Ltd. All rights reserved.

Effects of seasonal vitamin D deficiency and respiratory acidosis on bone metabolism markers in submarine crewmembers during prolonged patrols.

PubMed

Holy, Xavier; Collombet, Jean-Marc; Labarthe, Frédéric; Granger-Veyron, Nicolas; Bégot, Laurent

2012-02-01

The aim of the study was to determine the seasonal influence of vitamin D status on bone metabolism in French submariners over a 2-mo patrol. Blood samples were collected as follows: prepatrol and patrol days 20, 41, and 58 on crewmembers from both a winter (WP; n = 20) and a summer patrol (SP; n = 20), respectively. Vitamin D status was evaluated for WP and SP. Moreover, extended parameters for acid-base balance (Pco(2), pH, and bicarbonate), bone metabolism (bone alkaline phosphatase and COOH-terminal telopeptide of type I collagen), and mineral homeostasis (parathyroid hormone, ionized calcium and phosphorus) were scrutinized. As expected, SP vitamin D status was higher than WP vitamin D status, regardless of the considered experimental time. A mild chronic respiratory acidosis (CRA) was identified in both SP and WP submariners, up to patrol day 41. Such an occurrence paired up with an altered bone remodeling coupling (decreased bone alkaline phosphatase-to-COOH-terminal telopeptide of type I collagen ratio). At the end of the patrol (day 58), a partial compensation of CRA episode, combined with a recovered normal bone remodeling coupling, was observed in SP, not, however, in WP submariners. The mild CRA episode displayed over the initial 41-day submersion period was mainly induced by a hypercapnia resulting from the submarine-enriched CO(2) level. The correlated impaired bone remodeling may imply a physiological attempt to compensate this acidosis via bone buffering. On patrol day 58, the discrepancy observed in terms of CRA compensation between SP and WP may result from the seasonal influence on vitamin D status.

Air and Water Processes Do Not Produce the Same High-Quality Pasteurization of Donor Human Milk.

PubMed

Buffin, Rachel; Pradat, Pierre; Trompette, Jocelyne; Ndiaye, Isabelle; Basson, Eliane; Jordan, Isabelle; Picaud, Jean-Charles

2017-11-01

Holder pasteurization is the most commonly used technique in milk banks worldwide, but higher temperatures and longer pasteurization time have been associated with damage to the immune components of human milk. Research aim: This study aimed to assess the detailed pattern of pasteurization temperature using two water pasteurizers (WP1 and WP2) and one air pasteurizer (AP). The milk temperature during each phase of the pasteurization cycle was recorded using 6 to 9 probes, depending on the number of bottles, in the pasteurizers. We used 90 to 200 ml bottles to assess the effect of volume on milk temperature. The time to heat the milk from room temperature to 58°C was 12.4, 12.9, and 64.5 min, respectively, for WP1, WP2, and the AP ( p < .0001). The duration of the plateau was 35.5, 35.2, and 45.8 min ( p < .0001). The duration of exposure to a temperature above 58°C was 49.6, 40.7, and 76.2 min ( p < .0001). The total duration of a full cycle was 79, 66, and 182 min ( p < .0001). The duration of exposure above 58°C for the different volumes of milk treated showed no difference when using WP1 but was significantly longer in small volumes when using WP2. Human milk treated using the air pasteurizer in our study was exposed to higher temperatures and for longer periods of time than the water pasteurizers we employed. Regular qualification of pasteurizers is requested when evaluating the effect of pasteurization on milk components and for routine treatment of human milk in milk banks.

Assessment of Proposed Cab Glass Coating for FAA Control Towers

DTIC Science & Technology

2015-11-16

report would be prepared after the initial coating and evaluation (with sprayed water) and then a final report after the 6 month study period to assess...Distribution A: Approved for public release. AFRL-RH-WP-TR-2015-0074 Assessment of Proposed Cab Glass Coating for FAA Control...REPORT TYPE Interim 3. DATES COVERED (From - To) 30 Jun 2014 – 1 Nov 2015 4. TITLE AND SUBTITLE Assessment of Proposed Cab Glass Coating

A clinical evaluation of bleaching using whitening wraps and strips.

PubMed

Matis, Bruce A; Cochran, Michael; Wang, Ge; Franco, Miguel; Eckert, George J; Carlotti, Ronald J; Bryan, Christopher

2005-01-01

This study evaluated the degree of color change of teeth and the sensitivities of teeth and gums in an in vivo study. Ranir Whitening Wraps (WW2) and Crest Whitestrips Premium (WP2) were used twice a day and Ranir Whitening Wraps (WW1) were used once a day. Color evaluations occurred at baseline, after five and seven-day use of bleaching agent and 14 days post-bleaching. Color change was evaluated objectively and subjectively. Sensitivity evaluations were also accomplished. Seventy-six of the 78 subjects enrolled completed the study. All three products significantly lightened teeth. WW2 lightened more than WP2 and WW1 in L*, a*, b*, E and shade guide value. WP2 lightened more than WW1 in a*, b*, E and shade guide value. There was no difference in tooth sensitivity, but WW1 and WP2 caused less gingival sensitivity than WW2. The mean age of smokers was seven years younger than nonsmokers who qualified.

Influence of climate variability on near-surface ozone depletion events in the Arctic spring

NASA Astrophysics Data System (ADS)

Koo, Ja-Ho; Wang, Yuhang; Jiang, Tianyu; Deng, Yi; Oltmans, Samuel J.; Solberg, Sverre

2014-04-01

Near-surface ozone depletion events (ODEs) generally occur in the Arctic spring, and the frequency shows large interannual variations. We use surface ozone measurements at Barrow, Alert, and Zeppelinfjellet to analyze if their variations are due to climate variability. In years with frequent ODEs at Barrow and Alert, the western Pacific (WP) teleconnection pattern is usually in its negative phase, during which the Pacific jet is strengthened but the storm track originated over the western Pacific is weakened. Both factors tend to reduce the transport of ozone-rich air mass from midlatitudes to the Arctic, creating a favorable environment for the ODEs. The correlation of ODE frequencies at Zeppelinfjellet with WP indices is higher in the 2000s, reflecting stronger influence of the WP pattern in recent decade to cover ODEs in broader Arctic regions. We find that the WP pattern can be used to diagnose ODE changes and subsequent environmental impacts in the Arctic spring.

Comparisons of Growth and Survival Performance Among Selected Families and Wild Populations of Fenneropenaeus chinensis

NASA Astrophysics Data System (ADS)

Luo, Kun; Kong, Jie; Meng, Xianhong; Luan, Sheng; Cao, Baoxiang; Chen, Baolong

2018-04-01

In this study, families of selected population for growth (SP_BWT), selected population for white spot syndrome virus (WSSV) resistance (SP_RW), Bohai wild population (WP_BH) and Huanghai wild population (WP_HH) of F. chinensis were constructed through artificial insemination and with the standardized procedure of larvae rearing. Growth and survival performance were studied among four populations after a 70 days common test. The results showed that the maximum least square mean of body weight was 17.50 g in SP_BWT while the minimum was 13.03 g in WP_HH. Compared with WP_BH, body weight of SP_BWT increased by 23.41% ( P < 0.01) and that of SP_RW by 12.20% ( P > 0.05). Body weights of SP_BWT and SP_RW were significantly higher than that of WP_HH, which increased by 34.31% ( P < 0.01) and 22.10% ( P < 0.05), respectively. The mean AGR of four populations was 0.19, 0.18, 0.17 and 0.16 g d-1, respectively. Coefficient of variation of body weight among four populations was high, which ranged from 32.67% to 35.25%. Such a range showed that there was the potentiality for further improvement in selected populations. Coefficient of variation of survival rate among four populations was low, varying between 3.20% and 5.90%. The difference of survival was highly significant ( P < 0.01) between SP_BWT and WP_BH, and significant ( P < 0.05) between SP_RW and WP_BH. However, no significant difference among other populations ( P < 0.05) was observed. Different growth performances were also observed among different families in each population. The body weight of 798F family was the highest. The absolute growth rate (AGR) was 0.25 g d-1, 150% higher than that of the lowest one, 0.1 g d-1 in 807F family. Survival rate of families among four populations was different. The highest was 94.74%, and the lowest was 71.88%.

Do Returns to Schooling Differ by Race and Ethnicity? WP 2005-02

ERIC Educational Resources Information Center

Barrow, Lisa; Rouse, Cecilia Elena

2005-01-01

Using data from the U.S. Decennial Census and the National Longitudinal Surveys, we find little evidence of differences in the return to schooling across racial and ethnic groups, even with attempts to control for ability and measurement error biases. While our point estimates are relatively similar across racial and ethnic groups, our conclusion…

Combined cannabis/methaqualone withdrawal treated with psychotropic analgesic nitrous oxide.

PubMed

Gillman, Mark A; Harker, Nadine; Lichtigfeld, Frederick J

2006-07-01

This article reports the first single-blind study using psychotropic analgesic nitrous oxide (PAN) for treating acute withdrawal states following the abuse of methaqualone combined and smoked with cannabis. Smoked methaqualone combined with cannabis is called "white pipe" (WP). South Africa is the only country in the world where WP is a major form of substance abuse. This article demonstrates in 101 consecutively treated patients given placebo (100% oxygen) followed by PAN that this therapy produced a measurable therapeutic effect (more than 50% improvement) in 87 patients. This study confirms that WP is a form of substance abuse confined mainly to young adult male subjects.

AmeriFlux CA-WP3 Alberta - Western Peatland - Rich Fen (Carex)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flanagan, Lawrence B.

This is the AmeriFlux version of the carbon flux data for the site CA-WP3 Alberta - Western Peatland - Rich Fen (Carex). Site Description - Peatland (rich fen) Alberta. 54.47°N, 113.32°W Southwest of the AB-WPL site.

Behavior and milk production of buffalo cows as affected by housing system.

PubMed

De Rosa, G; Grasso, F; Braghieri, A; Bilancione, A; Di Francia, A; Napolitano, F

2009-03-01

To verify the effect of 2 housing systems (with and without a pool and an ample outdoor lot) on behavior and milk yield, 45 lactating buffalo cows were group-housed in a free stall open-sided barn with concrete floor where they received 10 m(2)/head as space allowance (group NP); 43 cows were group-housed in a similar barn, but had access to an outdoor yard (36 m(2)/head) and a concrete pool of 208 m(2) (group WP). Animals were subjected to 8 sessions of instantaneous scan sampling at approximately 10-d intervals. Behavioral variables were expressed as proportions of subjects observed in each category of posture and activity. In addition, rapid behaviors such as agonistic, social, and reproductive interactions, social licking, and self-grooming were recorded continuously. These variables were expressed as number of interactions per animal. At the end of each hour of observation, temperature and relative humidity were recorded. In WP the proportion of animals observed wallowing was 0.476 +/- 0.034, whereas lower proportions were observed standing (0.389 +/- 0.029) or lying (0.141 +/- 0.021) outside the pool. In NP the proportions of animals observed standing and lying were 0.452 +/- 0.042 and 0.548 +/- 0.042, respectively. A significant relationship between mean temperatures recorded on observation days and proportion of animals in the pool was observed (r(s) = 0.41). Fewer animals from group WP were observed idling compared with buffaloes from group NP (0.44 +/- 0.024 vs. 0.509 +/- 0.024, respectively), whereas more WP animals were involved in investigative activities than NP cows (0.099 +/- 0.009 vs. 0.042 +/- 0.009, respectively). A greater number of social interactions (sniffing and nuzzling) and social lickings were observed in group WP than in group NP (0.120 +/- 0.010 vs. 0.067 +/- 0.010, and 0.151 +/- 0.018 vs. 0.090 +/- 0.018, respectively). The WP buffalo cows had a greater milk yield than NP cows (11.73 +/- 0.31 vs. 10.78 +/- 0.28 kg/d, respectively), whereas no differences between groups were observed for protein (4.86 +/- 0.04 vs. 4.80 +/- 0.03% for WP and NP, respectively) and fat contents (8.49 +/- 0.14 vs. 8.38 +/- 0.13% for WP and NP, respectively). We conclude that the provision of a pool and an ample outdoor paddock can have beneficial effects on welfare and milk production of buffaloes.

pSW2, a Novel Low-Temperature-Inducible Gene Expression Vector Based on a Filamentous Phage of the Deep-Sea Bacterium Shewanella piezotolerans WP3.

PubMed

Yang, Xin-Wei; Jian, Hua-Hua; Wang, Feng-Ping

2015-08-15

A low-temperature-inducible protein expression vector (pSW2) based on a filamentous phage (SW1) of the deep-sea bacterium Shewanella piezotolerans WP3 was constructed. This vector replicated stably in Escherichia coli and Shewanella species, and its copy number increased at low temperatures. The pSW2 vector can be utilized as a complementation plasmid in WP3, and it can also be used for the production of complex cytochromes with multiple heme groups, which has the potential for application for metal ion recovery or bioremediation. Promoters of low-temperature-inducible genes in WP3 were fused into the vector to construct a series of vectors for enhancing protein expression at low temperature. The maximum green fluorescent protein intensity was obtained when the promoter for the hfq gene was used. The WP3/pSW2 system can efficiently produce a patatin-like protein (PLP) from a metagenomic library that tends to form inclusion bodies in E. coli. The yields of PLP in the soluble fraction were 8.3 mg/liter and 4.7 mg/liter of culture at 4°C and 20°C, respectively. Moreover, the pSW2 vector can be broadly utilized in other Shewanella species, such as S. oneidensis and S. psychrophila. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Smart Self-Assembled Nanosystem Based on Water-Soluble Pillararene and Rare-Earth-Doped Upconversion Nanoparticles for pH-Responsive Drug Delivery.

PubMed

Li, Haihong; Wei, Ruoyan; Yan, Gui-Hua; Sun, Ji; Li, Chunju; Wang, Haifang; Shi, Liyi; Capobianco, John A; Sun, Lining

2018-02-07

Exploring novel drug delivery systems with good stability and new structure to integrate pillararene and upconversion nanoparticles (UCNPs) into one system continues to be an important challenge. Herein, we report a novel preparation of a supramolecular upconversion nanosystem via the host-guest complexation based on carboxylate-based pillar[5]arene (WP5) and 15-carboxy-N,N,N-trialkylpentadecan-1-ammonium bromide (1)-functionalized UCNPs to produce WP5⊃1-UCNPs that can be loaded with the chemotherapeutic drug doxorubicin (DOX). Importantly, the WP5 on the surface of the drug-loaded nanosystem can be efficiently protonated under acidic conditions, resulting in the collapse of the nanosystem and drug release. Moreover, cellular uptake confirms that the nanosystem can enter human cervical cancer (HeLa) cells, resulting in drug accumulation in the cells. More importantly, cytotoxicity experiments demonstrated the excellent biocompatibility of WP5⊃1-UCNPs without loading DOX and that the nanosystem DOX-WP5⊃1-UCNPs exhibited an ability of killing HeLa cells effectively. We also investigated magnetic resonance imaging and upconversion luminescence imaging, which may be employed as visual imaging agents in cancer diagnosis and treatment. Thus, in the present work, we show a simple yet powerful strategy to combine UCNPs and pillar[5]arene to produce a unified nanosystem for dual-mode bioimaging-guided therapeutic applications.

Simulation of monsoon intraseasonal oscillations in a coarse-resolution aquaplanet GCM

NASA Astrophysics Data System (ADS)

Ajayamohan, R. S.; Khouider, Boualem; Majda, Andrew J.

2014-08-01

The skill of the global climate models (GCMs) to realistically simulate the monsoon intraseasonal oscillations (MISOs) is related to the sensitivity of their convective parameterization schemes. Here we show that by coupling a simple multicloud parameterization to a coarse-resolution aquaplanet GCM, realistic MISOs can be simulated. We conduct three different simulations with a fixed nonhomogeneous sea surface temperature mimicking the Indian Ocean/western Pacific warm pool (WP) centered at the three latitudes 5°N, 10°N, and 15°N, respectively, to replicate the seasonal migration of the Tropical Convergence Zone (TCZ). This results in the generation of mean circulation resembling the monsoonal flow pattern in boreal summer. Succession of eastward propagating Madden-Julian Oscillation (MJO) disturbances with phase speed, amplitude, and structure similar to summer MJOs are simulated when the WP is at 5°N. When the WP is located over 10°N, northward and eastward propagating MISOs are simulated. This case captures the meridional seesaw of convection between continental and oceanic TCZ observed during boreal summer over South Asia. Westward propagating Rossby wave-like disturbances are simulated when the WP is over 15°N congruous with the synoptic disturbances seen over the monsoon trough. The initiation of intraseasonal oscillations in the model can occur internally through organization of convective events above the WP associated with internal dynamics.

Geometry and controls on the development of igneous sill-related forced folds: 2D seismic reflection case study from offshore Southern Australia

NASA Astrophysics Data System (ADS)

Jackson, Christopher; Schofield, Nick; Magee, Craig; Golenkov, Bogdan

2017-04-01

Emplacement of magma in the shallow subsurface can result in the development of dome-shaped folds at the Earth's surface. These so-called 'forced folds' have been described in the field and in subsurface datasets, although the exact geometry of the folds and the nature of their relationship to underlying sills remains unclear and, in some cases, controversial. As a result, the utility of these features in tracking the subsurface movement of magma, and predicting the potential size and location of potentially hazardous volcanic eruptions, is uncertain. Here we use high-quality, 2D seismic reflection and borehole data from the Ceduna sub-basin, offshore southern Australia to describe the structure and infer the evolution of igneous sill-related forced folds in the Bight Basin Igneous Complex (BBIC). We mapped 33 igneous sills, which were emplaced 200-1500 m below the palaeo-seabed in an Upper Cretaceous, coal-bearing, predominantly coastal-plain succession. The intrusions, which are expressed as packages of high-amplitude reflections, are 32-250 m thick and 7-19 km in diameter. They are overlain by dome-shaped folds, which are up to 17 km wide and display up to 210 m of relief. The edges of these folds coincide with the margins of the underlying sills and the folds display the greatest relief where the underlying sills are thickest; the folds are therefore interpreted as forced folds that formed in response to emplacement of magma in the shallow subsurface. The folds are onlapped by Lutetian (middle Eocene) strata, indicating they formed and the intrusions were emplaced during the latest Ypresian (c. 48 Ma). We demonstrate that fold amplitude is typically less than sill thickness even for sills with very large diameter-to-depth ratios, suggesting that pure elastic bending (forced folding) of the overburden is not the only process accommodating magma emplacement, and that supra-sill compaction may be important even at relatively shallow depths. Based on the observation that the sills intruded a shallowly-buried succession, the discrepancy between fold amplitude and sill thickness may reflect loss of host rock volume by fluidisation and pore fluid expulsion from poorly-lithified, water-rich beds. This study indicates that host rock composition, emplacement depth and deformation mechanisms are important controls on the style of deformation that occurs during intrusive igneous activity, and that forced fold amplitude may not always reflect the thickness of an underlying igneous intrusion. In addition, the results of this study suggest that physical and numerical models need to model more complex host rock stratigraphies and rheologies if they wish to capture the full range of deformation mechanisms that occur during magma emplacement in the Earth's shallow subsurface.

Controlled directional scattering cavity for tubular absorbers

DOEpatents

Winston, Roland

1982-01-01

A specular cavity is provided in which an optical receiver is emplaced. The cavity is provided with a series of V groove-like indentations (or pyramidal-type indentations) which redirect energy entering between the receiver and cavity structure onto the receiver. The aperture opening of each V groove is less than half the cavity opening and in most preferred embodiments, much less than half. This enables the optical receiver to be emplaced a distance g from the cavity wherein 0.414r

77 FR 8818 - Publication of FY 2011 Service Contract Inventory

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

... the inventory on the Bureau's Open Government homepage at the following link: http://www.consumerfinance.gov/open/ , specifically at http://www.consumerfinance.gov/wp-content/uploads/2012/01/Appendix-C-FY2011-Inventory-Data-Summary.pdf and http://www.consumerfinance.gov/wp-content/uploads/2012/01/Appendix...

AmeriFlux CA-WP2 Alberta - Western Peatland - Poor Fen (Sphagnum moss)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flanagan, Lawrence B.

This is the AmeriFlux version of the carbon flux data for the site CA-WP2 Alberta - Western Peatland - Poor Fen (Sphagnum moss). Site Description - Peatland (poor fen) Alberta. 55.5375°N, 112.3343°W North of the AB-WPL site.

Monitoring Conditions Leading to SCC/Corrosion of Carbon Steel in Fuel Grade Ethanol

DOT National Transportation Integrated Search

2011-02-11

This is the draft final report of the project on field monitoring of conditions that lead to SCC in ethanol tanks and piping. The other two aspects of the consolidated program, ethanol batching and blending effects (WP#325) and source effects (WP#323...

Environmental Assessment: General Plan-Based Environmental Impact Analysis Process, Laughlin Air Force Base

DTIC Science & Technology

2007-05-01

BASED ENVIROMENTAL IMPACT ANALYSIS PROCESS LAUGHLIN AIR FORCE BASE, TEXAS AGENCY: 47th Flying Training Wing (FTW), Laughlin Air Force Base (AFB), Texas...8217\\ \\ \\ \\ \\\\ \\ ~ >(- \\ , ~ AOC01 \\ PS018 / WP002 \\ DP008 // WP006 \\ ~ ,/ ’----- -----·-------------~--/·/ LAUGHLIN AIR FORCE BASE ENVIROMENTAL RESTORATION

Constraining Controls on the Emplacement of Long Lava Flows on Earth and Mars Through Modeling in ArcGIS

NASA Astrophysics Data System (ADS)

Golder, K.; Burr, D. M.; Tran, L.

2017-12-01

Regional volcanic processes shaped many planetary surfaces in the Solar System, often through the emplacement of long, voluminous lava flows. Terrestrial examples of this type of lava flow have been used as analogues for extensive martian flows, including those within the circum-Cerberus outflow channels. This analogy is based on similarities in morphology, extent, and inferred eruptive style between terrestrial and martian flows, which raises the question of how these lava flows appear comparable in size and morphology on different planets. The parameters that influence the areal extent of silicate lavas during emplacement may be categorized as either inherent or external to the lava. The inherent parameters include the lava yield strength, density, composition, water content, crystallinity, exsolved gas content, pressure, and temperature. Each inherent parameter affects the overall viscosity of the lava, and for this work can be considered a subset of the viscosity parameter. External parameters include the effusion rate, total erupted volume, regional slope, and gravity. To investigate which parameter(s) may control(s) the development of long lava flows on Mars, we are applying a computational numerical-modelling to reproduce the observed lava flow morphologies. Using a matrix of boundary conditions in the model enables us to investigate the possible range of emplacement conditions that can yield the observed morphologies. We have constructed the basic model framework in Model Builder within ArcMap, including all governing equations and parameters that we seek to test, and initial implementation and calibration has been performed. The base model is currently capable of generating a lava flow that propagates along a pathway governed by the local topography. At AGU, the results of model calibration using the Eldgá and Laki lava flows in Iceland will be presented, along with the application of the model to lava flows within the Cerberus plains on Mars. We then plan to convert the model into Python, for easy modification and portability within the community.

Washoff of cypermethrin residues from slabs of external building material surfaces using simulated rainfall.

PubMed

Trask, Jennifer R; Harbourt, Christopher M; Miller, Paul; Cox, Megan; Jones, Russell; Hendley, Paul; Lam, Chung

2014-02-01

The use of pesticides by homeowners or pest-control operators in urban settings is common, yet contributions of washoff from these materials are not easily understood. In the present study, cypermethrin, formulated as Cynoff EC (emulsifiable concentrate) and Cynoff WP (wettable powder) insecticides, was applied at typical rates to 10 different building material surfaces to examine its washoff potential from each surface. Using an indoor rainfall simulator, a 1-h rainfall event was generated and washoff samples were collected from 3 replicates of each surface type. Washoff was analyzed for cypermethrin using gas chromatography-negative chemical ionization mass spectrometry. An analysis of variance for a split-plot design was performed. Many building materials had similar water runoff masses, but asphalt resulted in significantly reduced average water runoff masses (73% less). The Cynoff WP formulation generally produced greater cypermethrin washoff than the Cynoff EC formulation. In addition, results for both the WP and EC formulations indicated that smoother surfaces such as vinyl and aluminum siding had higher washoff (1.0-14.1% mean percentage of applied mass). Cypermethrin washoff from rough absorptive surfaces like concrete and stucco was lower and ranged from 0.1 to 1.3% and from 0 to 0.2%, respectively, mean percentage of applied mass. Both building material surface and formulation play a significant role in cypermethrin washoff. © 2013 The Authors. Environmental Toxicology and Chemistry Published by Wiley Periodicals, Inc. on behalf of SETAC.

Pyrobaculum Yellowstonensis Strain WP30 Respires On Elemental Sulfur And/or Arsenate in Circumneutral Sulfidic Sediments of Yellowstone National Park

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jay, Z.; Beam, Jake; Dohnalkova, Alice

Thermoproteales populations (phylum Crenarchaeota) are abundant in high-25 temperature (>70° C) environments of Yellowstone National Park (YNP) and are important in mediating biogeochemical cycles of sulfur, arsenic and carbon. The objectives of this study were to determine specific physiological attributes of the isolate Pyrobaculum yellowstonensis strain WP30, which was obtained from an elemental sulfur sediment (Joseph’s Coat Hot Spring [JCHS]; 80 °C; pH 6.1), and relate this organism to geochemical processes occurring in situ. Strain WP30 is a chemoheterotroph that utilizes organic carbon as a source of carbon and electrons and requires elemental sulfur and/or arsenic as electron acceptors. Growthmore » in the presence of elemental sulfur and arsenate resulted in the production of thioarsenates and polysulfides relative to sterile controls. The complete genome of this organism was sequenced (1.99 Mb, 58 % G+C) and revealed numerous metabolic pathways for the degradation of carbohydrates, amino acids and lipids, multiple dimethylsulfoxide molybdopterin (DMSO-MPT) oxidoreductase genes, which are implicated in the reduction of sulfur and arsenic, and pathways for the de novo synthesis of nearly all required cofactors and metabolites. Comparative genomics of P. yellowstonensis versus assembled metagenome sequence from JCHS showed that this organisms is highly-related (~95% average nucleotide identity) to in situ populations. The physiological attributes and metabolic capabilities of P. yellowstonensis provide importanat information towards understanding the distribution and function of these populations in YNP.« less

Hypersonic Flight Test Windows for Technology Development Testing

DTIC Science & Technology

2013-11-01

used. 2.1 Propulsion and Controls Test Window The technologies dealing with scramjet propulsion (inlets, fuel injection, etc.) and hypersonic ...AFRL-RQ-WP-TM-2013-0260 HYPERSONIC FLIGHT TEST WINDOWS FOR TECHNOLOGY DEVELOPMENT TESTING Barry M. Hellman Vehicle Technology Branch...DATES COVERED (From - To) November 2013 Final 01 November 2013 – 25 November 2013 4. TITLE AND SUBTITLE HYPERSONIC FLIGHT TEST WINDOWS FOR

77 FR 37477 - Federal Motor Vehicle Safety Standards; Glazing Materials

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-21

... 4. Half Pound Ball Drop--Tempered Glass 5. Fracture Test 6. Shot Bag and Dart Drop Tests 7. Half... Rapporteurs) that assist WP.29 in researching, analyzing and developing technical regulations. One of the GRs... proposal concerning markings for GTRs in general, at the one-hundred-and- fortieth session of WP.29 in...

Interim Particulate Matter Test Method for the Determination of Particulate Matter from Gas Turbine Engines, SERDP Project WP-1538 Final Report

EPA Science Inventory

Under Project No. WP-1538 of the Strategic Environmental Research and Development Program, the U. S. Air Force's Arnold Engineering Development Center (AEDC) is developing an interim test method for non-volatile particulate matter (PM) specifically for the Joint Strike Fighter (J...

Variability in Puff Topography and Exhaled CO in Waterpipe Tobacco Smoking.

PubMed

Kim, Hyoshin; Brinkman, Marielle C; Sharma, Eva; Gordon, Sydney M; Clark, Pamela I

2016-10-01

We examined intra-individual variability in puff topography and CO measures collected during laboratory waterpipe (WP) tobacco smoking using a research-grade waterpipe (RWP). WP smoking topography and exhaled CO measures were obtained from 10 established WP smokers in a single-blind, crossover design. Using a previously validated RWP, each participant smoked "Two Apples" WP tobacco ad libitum with a single quick-light charcoal to satiation in 3 laboratory sessions spaced at least one week apart. To examine the intra-individual variability, the intraclass correlation coefficient ( ρ ) for topography and CO measures were estimated. Results: The majority of the topography and CO measures were stable. Most stable were puff frequency ( ρ = 0.88), number of puffs ( ρ = 0.86), and puff duration (ρ = 0.80). Less stable were peak flow ( ρ = 0.57) and total puff volume ( ρ = 0.52). The results provide the first set of empirical evidence that most topography and CO measurements collected using the RWP from a single laboratory smoking session are stable such that they can be representative of a smoker's puffing behaviors and reproducible among 3 sessions spread equally across 3 weeks.

Fast co-pyrolysis of waste newspaper with high-density polyethylene for high yields of alcohols and hydrocarbons.

PubMed

Chen, Weimin; Shi, Shukai; Chen, Minzhi; Zhou, Xiaoyan

2017-09-01

Waste newspaper (WP) was first co-pyrolyzed with high-density polyethylene (HDPE) using pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) to enhance the yields of alcohols and hydrocarbons. The effects of WP: HDPE feed ratio (100:0, 75:25, 50:50, 25:75, 0:100) and temperature (500-800°C) on products distribution were investigated and the interaction mechanism during co-pyrolysis was also proposed. Maximum yields of alcohols and hydrocarbons reached 85.88% (feed ratio 50:50wt.%, 600°C). Hydrogen supplements and deoxidation by HDPE and subsequently fragments recombination result in the conversion of aldehydes and ketones into branched hydrocarbons. Radicals from WP degradation favor the secondary crack for HDPE products resulting in the formation of linear hydrocarbons with low carbon number. Hydrocarbons with activated radical site from HDPE degradation were interacted with hydroxyl from WP degradation promoting the formation of linear long chain alcohols. Moreover, co-pyrolysis significantly enhanced condensable oil qualities, which were close to commercial diesel No. 0. Copyright © 2017 Elsevier Ltd. All rights reserved.

Past- and present-day Madden-Julian Oscillation in CNRM-CM5

NASA Astrophysics Data System (ADS)

Song, Eun-Ji; Seo, Kyong-Hwan

2016-04-01

Madden-Julian Oscillation (MJO) in the past (nineteenth century) and present day (twentieth century) is examined using preindustrial and historical experiments of Centre National de Recherches Météorologiques-Coupled Models, version 5 (CNRM-CM5) in Coupled Model Intercomparison Project Phase 5 (CMIP5). The present-day MJO is stronger than the past MJO by 33% and it is ~10% more frequent. In particular, the MJO phases 4-7 signifying deep convection situated over the Maritime continent and western Pacific (WP) are considerably enhanced. These changes are due mainly to greenhouse gas forcing with little impact from nature forcing. Dynamical mechanisms for this change are investigated. A peculiar strengthening of MJO over WP comes from increased basic-state sea surface temperature (SST) over the Central Pacific (CP) and EP. The increase in precipitation over WP results from both the response to enhanced SST over CP and the inverted Walker circulation induced by the EP and CP SST increase. The latter causes a pair of anticyclonic Rossby waves straddling the equator, leading to moisture convergence over WP.

New well pattern optimization methodology in mature low-permeability anisotropic reservoirs

NASA Astrophysics Data System (ADS)

Qin, Jiazheng; Liu, Yuetian; Feng, Yueli; Ding, Yao; Liu, Liu; He, Youwei

2018-02-01

In China, lots of well patterns were designed before people knew the principal permeability direction in low-permeability anisotropic reservoirs. After several years’ production, it turns out that well line direction is unparallel with principal permeability direction. However, traditional well location optimization methods (in terms of the objective function such as net present value and/or ultimate recovery) are inapplicable, since wells are not free to move around in a mature oilfield. Thus, the well pattern optimization (WPO) of mature low-permeability anisotropic reservoirs is a significant but challenging task, since the original well pattern (WP) will be distorted and reconstructed due to permeability anisotropy. In this paper, we investigate the destruction and reconstruction of WP when the principal permeability direction and well line direction are unparallel. A new methodology was developed to quantitatively optimize the well locations of mature large-scale WP through a WPO algorithm on the basis of coordinate transformation (i.e. rotating and stretching). For a mature oilfield, large-scale WP has settled, so it is not economically viable to carry out further infill drilling. This paper circumvents this difficulty by combining the WPO algorithm with the well status (open or shut-in) and schedule adjustment. Finally, this methodology is applied to an example. Cumulative oil production rates of the optimized WP are higher, and water-cut is lower, which highlights the potential of the WPO methodology application in mature large-scale field development projects.

Waterpipes and e-cigarettes: Impact of alternative smoking techniques on indoor air quality and health

NASA Astrophysics Data System (ADS)

Fromme, Hermann; Schober, Wolfgang

2015-04-01

Waterpipe (WP) smoking is growing as an alternative to cigarette smoking, especially in younger age groups. E-cigarette use has also increased in recent years. A majority of smokers mistakenly believe that WP smoking is a social entertainment practice that leads to more social behavior and relaxation and that this type of smoking is safe or less harmful and less addictive than cigarette smoking. In reality, WP smokers are exposed to hundreds of toxic substances that include known carcinogens. High exposures to carbon monoxide and nicotine are major health threats. Persons exposed to secondhand WP smoke are also at risk. There is growing evidence that WP smoke causes adverse effects on the pulmonary and cardiovascular systems and is responsible for cancer. E-cigarettes are marketed as a smokeless and safe way to inhale nicotine without being exposed to the many toxic components of tobacco cigarettes, and as an aid to smoking cessation. In fact, consumers (vapers) and secondhand vapers can be exposed to substantial amounts of VOC, PAH or other potentially harmful substances. Of major health concern is the inhalation of fine and ultrafine particles formed from supersaturated 1,2-propanediol vapor. Such particles can be deposited in the deeper parts of the lung and may harm the respiratory system or increase the risk of acquiring asthma. More research on the safety of e-cigarettes needs to be conducted to ensure a high level of public health protection in the long-term.

Changes in soil properties and in the growth of Lolium multiflorum in an acid soil amended with a solid waste from wineries.

PubMed

Nóvoa-Muñoz, J C; Simal-Gándara, J; Fernández-Calviño, D; López-Periago, E; Arias-Estévez, M

2008-10-01

The agronomic utility of a solid waste, waste perlite (WP), from wine companies was assessed. In this sense, the natural characteristics of the waste were measured, followed by the monitoring of its effects on the chemical properties of acid soils and the growth of Lolium multiflorum. Taking into account that heavy metals associated to the waste (such as Cu, Zn and Mn) could cause problems when used as amendment, the changes in their total levels and in their soil fractionation were also studied, together with their total contents in L. multiflorum. The high content in C (214gkg(-1)), N (25gkg(-1)), P (534mgkg(-1)) and K (106gkg(-1)) of WP turned it into an appropriate amendment to increase soil fertility, solving at the same time its disposal. WP contributed to increase soil pH (in 2 pH units) and cation exchange capacity (CEC increased in 3cmolckg(-1)units), but reduced the potential Cu phytotoxicity due to a change in Cu distribution towards less soluble fractions. The growth of L. multiflorum adequately responds to the treatment with WP at addition rates below 2.5gkg(-1), whereas the imbalance between nutrients can justify the reduction in biomass production at higher WP addition rates. The levels of heavy metals analyzed in L. multiflorum biomass (8-85gkg(-1)) do not seem to cause undesirable effects on its growth.

Prostate Zonal Volumetry as a Predictor of Clinical Outcomes for Prostate Artery Embolization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Assis, André Moreira de, E-mail: andre.assis@criep.com.br, E-mail: andre.maa@gmail.com; Maciel, Macello Sampaio, E-mail: macielmjs@gmail.com; Moreira, Airton Mota, E-mail: airton.mota@criep.com.br

PurposeTo determine prostate baseline zonal volumetry and correlate these findings with clinical outcomes for patients who underwent prostate artery embolization (PAE) for lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH).Materials and MethodsThis is a retrospective study that included patients treated by PAE from 2010 to 2014. Baseline and 6-month follow-up evaluations included prostate MRI with whole prostate (WP) and central gland (CG) volume measurements—as well as prostate zonal volumetry index (ZVi) calculation, defined as the CG/WP volumes relation—the International Prostate Symptom Score (IPSS), and the Quality of life (QoL) index. Baseline WP, CG, and ZVi were statistical compared to IPSS andmore » QoL values at 6 months.ResultsA total of 93 consecutive patients were included, with mean age of 63.4 years (range, 51–86). Clinical failure, defined as IPSS > 7 or QoL > 2, was seen in four cases (4.3%). Mean reductions in prostate volumes after PAE were of 30.6% and 31.2% for WP and CG, respectively (p < 0.0001). Clinical parameters had mean decrease from 21 to 3.3 points for IPSS, and from 4.7 to 1.2 points for QoL (p < 0.0001). Baseline WP, CG, and ZVi correlated to the degree of clinical improvement (p < 0.05 for all). The baseline ZVi cut-off calculated for better clinical outcomes was > 0.45, with 85% sensitivity and 75% specificity.ConclusionsBaseline CG and WP volumes as well as ZVi presented strong correlation with clinical outcomes in patients undergoing PAE, and its assessment should be considered in pre-treatment evaluation whenever possible. Both patients and medical team should be aware of the possibility of less favorable outcomes when ZVi < 0.45.« less

Neutrophil depletion in the early inflammatory phase delayed cutaneous wound healing in older rats: improvements due to the use of un-denatured camel whey protein

PubMed Central

2014-01-01

Background While it is known that advanced age alters the recruitment of neutrophils during wound healing, thereby delaying the wound healing process, little is known about prolonged wound healing in advanced ages. Thus, we investigated the correlation of neutrophil recruitment with healing events, and the impact of whey protein (WP) on neutrophil activation. Methods The animals were allocated into wounded young group, wounded older group and wounded older rats with daily treatment of WP at a dose of 100 mg/kg of body weight. Results Our results pointed to a marked deficiency in the number of neutrophils in the wounds of older rats, which was accompanied with impairment of the healing process. In the group of older rats, phagocytic activity, as tested by fluorescence microscopy, declined throughout the first 24 hours after wounding. Both the neutrophil number and the phagocytic activity recovered in older rats which received WP supplementation. Interestingly, WP was found to significantly up-regulate the MIP-1α and CINC-1 mRNA expression in old rats. On the other hand, the wound size in older rats was significantly higher than that in younger ones. Blood angiogenesis was also significantly delayed in the older group as opposed to the young rats. WP, however, was found to return these indices to normal levels in the older rats. Proliferation and epidermal migration of the keratinocytes and the collagen deposition were also returned to the normal rates. Conclusions This data confirms the critical role of neutrophil recruitment in the early inflammatory phase of wound healing in older rats. In addition, WP protein was used to improve neutrophil function in older rats, healing events returned to a more normal profile. Virtual slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2100966986117779. PMID:24593823

Land and water use practices intended to increase water productivity in arid and semi-arid zones. Application to Uzbekistan.

NASA Astrophysics Data System (ADS)

Mirshadiev, Mirzokhid; Fleskens, Luuk; van Dam, Jos; Pulatov, Alim

2017-04-01

Water demand increases as more food is required to meet population growth and higher living standards. In addition, climate change is expected to further exacerbate water scarcity in already dry areas where irrigation is most needed. In the water scarce areas, the key strategy to meet demand of growing food production and water use is increase of water productivity (WP) based on best land and water use practices. A literature review will be conducted to study promising land and water use practices that increase water productivity in arid and semi-arid zones, with a special focus on Uzbekistan. In addition to literature review we will conduct interviews with local farmers and land and water management experts. However, due to time constraints and difficult to access grey literature, the review paper cannot cover all promising land and water use practices that have been used in Uzbekistan. We selected the following promising practices: a) conventional furrow irrigation; b) deficit irrigation; c) drip/sprinkle irrigation, and d) rain-fed with supplemental irrigation. The preliminary findings of the literature review show that in Uzbekistan in case of conventional furrow irrigation the WP range of cotton was 0.32-0.89, and of wheat 0.44-1.77 (kg m3). By applying deficit irrigation practices, WP values of cotton can be 0-25% higher (0.32-1.11 kg m3), and of wheat 114-400% higher (2.20-3.78 kg m3). However, deficit irrigation practices for potato's need to be managed carefully to reach higher WP, and might even negatively effect WP, showing a range of 0.85-7.04 compared to conventional furrow irrigation 4.02-4.81 (kg m3). Important to mention that drip irrigation practice can highly contribute to increase WP of cotton by 156-91 % (0.82-1.70 kg m3) compared to furrow irrigation. Also, rain-fed cultivation with supplemental irrigation result is anticipated and will be included in the presentation and full version of paper. In summary, the review of current land and water use practices shows promising increases of WP values for cotton, wheat and potato crops in case of Uzbekistan.

Determinants associated with work participation in patients with established rheumatoid arthritis taking tumor necrosis factor inhibitors.

PubMed

Manders, Sofie H M; Kievit, Wietske; Braakman-Jansen, Annemarie L M A; Brus, Herman L M; Hendriks, Lidy; Fransen, Jaap; van de Laar, Mart A F J; van Riel, Piet L C M

2014-07-01

Reduced work participation (WP) is a common problem for patients with rheumatoid arthritis (RA) and generates high costs for society. Therefore, it is important to explore determinants of WP at the start of tumor necrosis factor inhibitor (TNFi) treatment, and for changes in WP after 2 years of TNFi treatment. Within the Dutch Rheumatoid Arthritis Monitoring (DREAM) biologic register, WP data were available from 508 patients with RA younger than 65 years and without an (early) retirement pension. WP was registered at start of TNFi treatment and after 2 years of followup and was measured by single patient-reported binary questions whether they had work, paid or voluntary, or had a disability allowance or a retirement pension. Determinants measured at baseline were age, sex, disease duration, functional status [through Health Assessment Questionnaire-Disability Index (HAQ-DI)], 28-joint Disease Activity Score (DAS28), rheumatoid factor, presence of erosions, number of previous disease-modifying antirheumatic drugs, and number of comorbidities. During the 2 years of followup, HAQ-DI response and European League Against Rheumatism response were measured. Univariate analyses (excluded if p value was > 0.2) and multivariate (excluded if p value was > 0.1) logistic regression analyses were used. Determinants associated with WP at baseline were having a better HAQ-DI (OR 0.32, p = 0.000) and male sex (OR 0.65, p = 0.065). After 2 years of TNFi therapy, 11.8% (n = 60) started to work and 13.6% (n = 69) stopped working. Determinants associated with starting to work were better baseline HAQ-DI (OR 0.58), positive RF (OR 2.73), and young age (OR 0.96); and for stopping work, worse baseline HAQ-DI (OR 2.74), low HAQ-DI response (OR 0.31), and comorbidity (OR 2.67), all with p < 0.1. Young patients with RA and a high functional status without any comorbidity will have a better chance of working. This supports the main goal in the management of RA: to suppress disease activity as soon and as completely as possible to prevent irreversible destruction of the joints, and thus maintain a good functional status of the patient. Because of the low proportion of variance explained by the models in this study, other factors besides the ones studied are associated with WP.

Aqueous Productivity: An enhanced productivity indicator for water

NASA Astrophysics Data System (ADS)

Ritzema, Randall S.

2014-09-01

Increasing demand for scarce water supplies is fueling competition between agricultural production and other municipal and environmental demands, and has heightened the need for effective indicators to measure water performance and support water allocation and planning processes. Water productivity (WP), defined as the ‘ratio of the net benefits from crop, forestry, fishery, livestock, and mixed agricultural systems to the amount of water required to produce those benefits', is one such indicator that has gained prominence, particularly in research-for-development efforts in the developing world. However, though WP is a framework well-suited to systems where water use is directly attributable, particularly via depletion, to definitive benefits, the suitability of the approach becomes questionable when these conditions are not met, such as in multiple use systems with high re-use and non-depleting uses. These factors furthermore make WP highly scale-dependent, complicating comparative studies across scales and systems. This research forwards ‘aqueous productivity' (AP) as an alternative indicator that addresses some inherent limitations in the WP approach and enhances productivity estimates for water in integrated systems. Like WP, AP is expressed as a ratio of benefit to water volume. However, AP uses a systems approach and is based on the concept that elements within a hydrologic system are linked via water flow interactions, and that those elements either ‘extract' value from associated water flows or ‘infuse' value into them. The AP method therefore calculates the ‘aqueous productivity', a ratio indicating the ‘dissolved' production-related economic value of all downstream uses of an individual water flow, for each inter-element and cross-boundary flow in the system. The AP conceptual framework and analytical methodology are presented. The method is then applied to two example hydroeconomic systems and compared to equivalent WP analysis. Discussion compares and contrasts the two methods, with a particular focus on how the AP approach addresses limitations in the WP method through its treatment of multiple uses of water and water re-use, seamless integration of depleting and non-depleting water uses, explicit cross-scale linkages, and incorporation of water storage and other temporal aspects in the analysis. Appropriate contexts of application for AP in decision support and in contrast to other water valuation methods are consequently considered.

Non Chromate, ZVOC Coatings for Steel Substrates on Army and Navy Aircraft and Ground Vehicles: Non Chromate Sealers for Zinc Phosphate

DTIC Science & Technology

2017-04-30

Defense, “Chemical Agent Resistant Coating (CARC) System Application Procedures and Quality Control Inspection”, Washington, DC, June 2003. 4. Non ...WP-200906) Non -Chromate, ZVOC Coatings for Steel Substrates on Army and Navy Aircraft and Ground Vehicles Non -Chromate Sealers for Zinc...comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE

Varied representation of the West Pacific pattern in multiple dynamical seasonal predictions of APCC-MME

NASA Astrophysics Data System (ADS)

Lee, Yun-Young

2017-04-01

West Pacific (WP) teleconnection pattern is one of the well-known primary modes of boreal winter low-frequency variability (LFV) resolved in 500 hPa geopotential height and its phase and amplitude strongly influence regional weather conditions including temperature and rainfall extremes [Baxter and Nigam, 2015; Hsu and Wallace, 1985; Linkin and Nigam, 2008; Mo and Livezey, 1986; Thompson and Wallace, 1998; Wallace and Gutzler, 1981]. This study primary aims to evaluate individual 11 GCMs seasonal hindcasts employed as members of multi-model ensemble (MME) produced in APEC Climate Center (APCC) in representing WP. For the extensive and comprehensive evaluation, this study applied seven verification metrics in three scopes: (a) temporal representation of observed indices, (b) spatial mode separation in the Northern Hemisphere (NH), and (c) regional mode isolated in the preset longitudinal domain. Verification results display quite large inter-model spread. Some models mimic observed index variability while others display large bias of index variability compared to climatology. Basic north-south dipole pattern is mostly well reproduced in both rotated and unrotated loading modes. However, each individual seasonal forecast model exhibits slightly different behavior (e.g. amplification/weakening, zonal and meridional shift, downstream extension and so forth) in representing spatial structure of WP. When taking all 7 metrics into account, one Europe (CMCC) model, one Oceania (POAMA) model and two North America (NASA and NCEP) models are classified as relatively good performers while PNU is classified as a matchless poor performer out of 11. Least WP representing skill of PNU is sort of consistent with the largest bias of NH total variability. This study further tries to examine winter mean biases of individual models and figure out how mean bias is linked to WP representation in model world. Model bias of winter climatology is investigated focusing on six large scale phenomena: East Asian winter monsoon (EAWM), Atlantic dipole, Pacific/Atlantic jets and Pacific/Atlantic Hadley circulations. Changes in structure and amplitude of them are diagnosed in terms of root mean square error, pattern correlation, intensity bias, zonal displacement and/or downstream extension. There is consistent strengthening/downstream extension of Atlantic jet and absence of southern divergence cell of Atlantic Hadley in most seasonal prediction models. It is demonstrated that WP representation has something to do with bias of Atlantic winter climatology (Atlantic dipole and Atlantic jet) from scatter plot and regression analysis. This implies the importance of realistic simulation of winter climatology further upstream for better WP representation. A fundamental conclusion of this study is that the representation of primary WP features varies among individual models of APCC-MME and it is significantly dependent on the deficiencies of some winter mean climatological patterns.

Igneous Sheet Intrusions as a Record of Paleostress States

NASA Astrophysics Data System (ADS)

Stephens, T. L.; Walker, R. J.; Healy, D.; Bubeck, A.; England, R. W.; McCaffrey, K. J. W.

2017-12-01

The architecture of igneous sheet intrusion networks provides useful constraints on paleostress during emplacement. Several models for sill emplacement have used the close spatial relationships between sills and dikes in layered (sedimentary) host rocks to propose that dike-sill transitions are driven by layering. Such models require a stress rotation - from horizontal extension for dikes, to horizontal compression for sills - which is assumed to reflect a near-hydrostatic stress state, facilitating the dilation and intrusion of pre-existing structures (e.g. faults, joints, and bedding). Here, we present case examples of sills for which layering is not the main control on emplacement: Isle of Mull (UK), Faroe Islands (European Atlantic margin) and the San Rafael Subvolcanic Field (Utah, USA). In each case, dikes cut, or are cut by, sills; indicating that dikes were not the feeders to sills in the same section. The sills consist of linked, flat and shallowly-dipping segments that always show near-vertical opening directions. Sills cut bedding and formation contacts with consistent low-angle dips, and cut or abut against vertical faults, fractures, and tectonic foliations. From this, we infer that magma pressure during emplacement did not exceed the horizontal stress. To constrain the stress state during emplacement we present a novel approach that combines analysis of local and overall sill geometry data with mechanical models for slip tendency, dilation tendency, and fracture susceptibility. We also present a new depth-independent mechanical model, which estimates paleostress ratio and driving fluid pressure ratio using the opening angles of dilated fluid-filled fractures. Our results show that the studied sills record previously unrecognised local fluctuations in the far-field stress state, during magmatic supply. Sills, therefore, present an important tool for determining paleostress in areas where few brittle deformation structures (e.g. faults), other than intrusions, are present.

Deep Borehole Emplacement Mode Hazard Analysis Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sevougian, S. David

This letter report outlines a methodology and provides resource information for the Deep Borehole Emplacement Mode Hazard Analysis (DBEMHA). The main purpose is identify the accident hazards and accident event sequences associated with the two emplacement mode options (wireline or drillstring), to outline a methodology for computing accident probabilities and frequencies, and to point to available databases on the nature and frequency of accidents typically associated with standard borehole drilling and nuclear handling operations. Risk mitigation and prevention measures, which have been incorporated into the two emplacement designs (see Cochran and Hardin 2015), are also discussed. A key intent ofmore » this report is to provide background information to brief subject matter experts involved in the Emplacement Mode Design Study. [Note: Revision 0 of this report is concentrated more on the wireline emplacement mode. It is expected that Revision 1 will contain further development of the preliminary fault and event trees for the drill string emplacement mode.]« less

Martian rampart crater ejecta - Experiments and analysis of melt-water interaction

NASA Astrophysics Data System (ADS)

Wohletz, K. H.; Sheridan, M. F.

1983-10-01

Viking images of Martian craters with rampart-bordered ejecta deposits reveal distinct impact ejecta morphology when compared to that associated with similar-sized craters on the Moon and Mercury. It is suggested that target water explosively vaporized during impact alters initial ballistic trajectories of ejecta and produces surging flow emplacement. The dispersal of particulates during a series of controlled steam explosions generated by interaction of a thermite melt with water has been experimentally modeled. Study of terrestrial, lobate, volcanic ejecta produced by steam-blast explosions reveals that particle size and vapor to clast volume ratio are primary parameters characterizing the emplacement mechanism and deposit morphology.

76 FR 38115 - Notice of Petitions by Firms for Determination of Eligibility To Apply for Trade Adjustment...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-29

..., product designing, progressive dies, molds, and jig fixtures. WP Manufacturing, Inc. DBA WP 802 South... thereof, and to a decrease in sales or production of each petitioning firm. List of Petitions Received By... Avenue, 6/21/2011 The firm manufactures plated York, PA 17404. finishes, to ASTM and military...

New Perspectives: Using Participatory Photography to Evaluate Widening Participation Interventions

ERIC Educational Resources Information Center

Raven, Neil

2015-01-01

With much emphasis now placed upon determining the effectiveness of widening participation (WP) interventions, there is value in identifying evaluation methods best able to provide insights into the impact of this work. One method that has received little attention in the field of WP and yet has considerable potential in this respect is associated…

PHYSICAL REMOVAL OF MICROBIAL CONTAMINANTS IN DRINKING WATER – WATTS PREMIER INC. WP-4V DRINKING WATER TREATMENT SYSTEM

EPA Science Inventory

The Watts Premier WP-4V four-stage POU RO system was tested for removal of bacteria and viruses at NSF’s Drinking Water Treatment Systems Laboratory. Five systems were challenged with the bacteriophage viruses fr and MS2, and the bacteria Brevundimonas diminutaEM. The ...

A Comparison of Web Page and Slide/Tape for Instruction in Periapical and Panoramic Radiographic Anatomy.

ERIC Educational Resources Information Center

Ludlow, John B.; Platin, Enrique

2000-01-01

Compared self-guided slide/tape (ST) and Web page (WP) instruction in normal radiographic anatomy of periapical and panoramic images using objective test performance and subjective preferences of 74 freshman dental students. Test performance was not different between image types or presentation technologies, but students preferred WP for…

Being Altruistically Motivated: The Postgraduate and Career Motivational Orientations of Access Students at an Irish University

ERIC Educational Resources Information Center

Keane, Elaine

2017-01-01

The relative lack of research about postgraduate education, and especially from a widening participation (WP) perspective, is noteworthy in a context of an increasingly expanding and important postgraduate sector internationally. This paper draws on the findings of a study about the "impact" of WP initiatives at an Irish university,…

Downhole material injector for lost circulation control

DOEpatents

Glowka, D.A.

1991-01-01

This invention is comprised of an apparatus and method for simultaneously and separately emplacing two streams of different materials through a drillstring in a borehole to a downhole location for lost circulation control. The two streams are mixed outside the drillstring at the desired downhole location and harden only after mixing for control of a lost circulation zone.

Downhole material injector for lost circulation control

DOEpatents

Glowka, D.A.

1994-09-06

Apparatus and method are disclosed for simultaneously and separately emplacing two streams of different materials through a drill string in a borehole to a downhole location for lost circulation control. The two streams are mixed outside the drill string at the desired downhole location and harden only after mixing for control of a lost circulation zone. 6 figs.

40 CFR 194.43 - Passive institutional controls.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., design, and contents of the disposal system. Such measures shall include: (1) Identification of the controlled area by markers that have been designed and will be fabricated and emplaced to be as permanent as... system; (ii) The design of the disposal system; (iii) The nature and hazard of the waste; (iv) Geologic...

40 CFR 194.43 - Passive institutional controls.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., design, and contents of the disposal system. Such measures shall include: (1) Identification of the controlled area by markers that have been designed and will be fabricated and emplaced to be as permanent as... system; (ii) The design of the disposal system; (iii) The nature and hazard of the waste; (iv) Geologic...

The Role of Cooling in Pahohoe Emplacement on Planetary Surfaces.

NASA Technical Reports Server (NTRS)

Glaze, L. S.; Baloga, S. M.

2015-01-01

Abundant evidence is emerging that many lavas on Mars were emplaced as slow-moving pahoehoe flows. Models for such scenarios contrast sharply with those for steep-sloped applications where gravity is the dominant force. The mode of flow emplacement on low slopes is characterized by toe formation and inflation. In the latter phase of pahoehoe flow emplacement, stagnation, inflation, and toe formation are most closely tied to the final topography, dimensions, and morphologic features. This mode of emplacement is particularly relevant to the low slopes of planetary surfaces such as the plains of Mars, Io and the Moon.

Tailored Fitness: Culture Clash in the Quest for Combat-Fit Airmen

DTIC Science & Technology

2014-06-01

and conditioning; tobacco cessation, prevention and deglamorization; drug and alcohol abuse awareness and prevention ; general nutrition for all...ages; injury and disease risk education; and stress management and prevention .”6 AFI 36-2905 highlights three other documents that work in...Illustration taken from Center for Disease Control and Prevention Young Adult Obesity Rates Web Site: http://climatecycle.com/newsite/wp- content

Clinical effect of four different ointment bases on healthy cat eyes.

PubMed

Eördögh, Réka; Schwendenwein, Ilse; Tichy, Alexander; Loncaric, Igor; Nell, Barbara

2016-07-01

To describe the effects of long-term treatment with four different eye ointment bases (OBs) in cats. Ten healthy cats. The study was performed in two periods. Four different OBs were tested. Hundred grams of OB contained the following: OB-A: 35.17 g liquid paraffin (lp), 64.83 g white petrolatum (wp); OB-B: 10.03 g lp, 84.95 g wp 5.02 g lanolin; OB-C: 18.34 g lp, 51.40 g wp, 25.00 mg KH2 PO4 , 57.00 mg K2 HPO4 , 18.90 g eucerinum anhydricum, 11.28 g water for injections; and OB-D: 70 g unguentum lanalcoli, 20 g lp, 10 g aqua conservans. One eye was treated, and the other served as a negative control. Cats received the OBs TID for 28 days. The two study periods were separated by a 4-month washout phase. Samples for conjunctival impression cytology, swabs for bacteriologic and mycologic examination, and cytobrush samples for FHV-1 and Chlamydophila felis PCR detection were obtained. Both eyes were examined daily. Severity of ocular symptoms was scored using a modified Draize eye irritation test. A total of five eyes were treated with OB-A, five with OB-B, four with OB-C, and five with OB-D. Treated eyes had significantly higher clinical scores. Eyes receiving OB-A had the highest overall clinical score. The results of bacteriologic and mycologic examination concur with the previously published data. All samples tested were negative for FHV-1 and Chlamydophila felis. There was no significant difference between treated and control eyes upon cytological examination. The application of OBs resulted in clinical symptoms in treated eyes. The long-term use of ointments is not well tolerated in cats and may lead to ocular irritation. © 2015 American College of Veterinary Ophthalmologists.

Growth in an English population from the Industrial Revolution.

PubMed

Mays, S; Brickley, M; Ives, R

2008-05-01

The rapid urbanization of the Industrial Revolution in 18th-19th century England presented new health challenges. Our aim is to investigate using English skeletal remains whether the living conditions for an urban working class group in the Industrial Revolution negatively impacted upon their skeletal growth compared with a population from a rural agrarian parish. The Industrial Revolution skeletal material is from St Martin's Churchyard, Birmingham (SMB), West Midlands. It dates primarily from the first half of the nineteenth century when Birmingham was a major manufacturing center. The rural group is from Wharram Percy (WP), North Yorkshire, and dates from 10th-19th century AD. The methodology involves plotting diaphyseal bone lengths versus dental age for subadults. No overall difference was found between the two populations in bone length-for-age among the 2- to 18-year cohort. However the younger parts of the SMB cohort were smaller than at WP; the opposite was true of the older parts of the cohort. Growth rate, as inferred from crosssectional data, appeared greater at SMB than at WP. The only result consistent with expectations is the larger bone dimensions in young children from WP, but this likely reflects prolonged breastfeeding at WP not differences in urban and rural environments. That the deleterious health effects that we know accompanied the major transition in human society from a rural agrarian to an urban industrialized living environment should be little manifest in skeletal endochondral growth data is discouraging for those who would use such methodology to monitor health in earlier populations. (c) 2008 Wiley-Liss, Inc.

Functional Biomaterials: Solution Electrospinning and Gelation of Whey Protein and Pullulan

NASA Astrophysics Data System (ADS)

Sullivan, Stephanie Tolstedt

Utilizing biomaterials that are biodegradable, biocompatible and edible serve well for food products as well as biomedical applications. Biomaterials whey protein and pullulan both have these characteristics. Whey proteins (WP) have been used in food products for many years and more recently in pharmaceutical products. They have the ability to form both gels and stable foams. Pullulan (PULL) has also been used in both food and pharmaceutical products, and is a highly water soluble, non-gelling polysaccharide and has been used primarily as a film former. Herein, we investigate the ability of whey protein and pullulan to form nanofibers and gels. Combining their distinct properties allows the ability to uniquely manipulate nanofiber and gel characteristics and behavior for a variety of applications, from food to even tissue scaffolding. First, we determined the electrospinnability of aqueous whey protein solutions. Both whey protein isolate (WPI) and one of its major components beta--lactoglobulin (BLG), either in native or denatured form, yielded interesting micro and nanostructures when electrosprayed; while nanofiber production required blending with a spinnable polymer, poly(ethylene oxide) (PEO). WP:PEO solutions were also successfully electrospun at acidic pH (2≤pH≤3), which could improve shelf life. Fourier Transform Infrared Reflectance (FTIR) analysis of WP:PEO fiber mat indicated some variation in WP secondary structure with varying WPI concentration (as WPI increased, % alpha-helix increased and beta-turn decreased) and pH (as pH decreased from neutral (7.5) to acidic (2), % beta-sheet decreased and alpha-helix increased). X-ray Photoelectron Spectroscopy (XPS) also confirmed the presence of WP on the surface of the blend fibers, augmenting the FTIR analysis. Interestingly, WP:PEO composite nanofibers maintained its fibrous morphology at temperatures as high as 100 °C, above the 60 °C PEO melting point. Further, we show that the blend mats retained a fibrous structure after the heat treatment. Our second goal was to evaluate the ability of aqueous blends of whey protein and pullulan to form gels. We first looked at WP-PULL blend solutions at room temperature, finding an increasing linear trend in low shear viscosity as the relative concentration of pullulan increased. Blend solution samples were then heated to determine the ability of the blend solutions to form a gelled network. Starting with a homogeneous WP gel, adding PULL, at native mix or alkaline pH, maintained a transparent homogeneous microstructure, but resulted in weaker gels based on its response to stress. At WP isoelectric point (IEP) pH, both protein and blend gels became opaque due to protein aggregation, forming a particulate gel. All gels at the IEP were weaker, yielding at much lower stress and corresponding strain, due to the protein aggregation. The addition of transglutaminase enzyme yielded a stronger network than the native samples, while the addition of sodium trimetaphosphate salt yielded weaker gels and also induced relevant particle and/or course stranded microstructure in both pH 8 and IEP cases. The third part of this study demonstrated the ability of pullulan to form nanofibers in the solution electrospinning process. Aqueous pullulan solutions were able to form defect-free nanofibers with a minimum concentration of 15 w/w%. Pullulan and PULL:hydroxypropyl-beta- cyclodextrin (HPBCD) blend fibers were chemically crosslinked to form insoluble fibers using ethylene glycol diglycidyl ether (EGDGE), a chemical used in food contact coating applications. Next, solution blends of pullulan with whey protein were prepared and also electrospun at varying pH and relative biomaterial concentrations at 17 total w/w%. PULL-WP blend nanofiber mats were crosslinked via heat treatment and found to be both swellable and insoluble. When dried, the mats did not return to their original fiber state and instead appear to be gelatinous fibers in nature after soaking, and thereby making them potentially useful for tissue scaffolding applications. A fourth accomplishment was to utilize Near Infrared Reflectance (NIR) Spectroscopy and Chemometrics techniques to analyze commercial whey protein powder characteristics such as protein, fat and moisture content as well as pH. NIR has been utilized in the food and pharmaceutical industries for quality control as a valuable compliment to or replacement for more expensive testing such as High Performance Liquid Chromatography. Analysis resulted in the development of quantitative, linear regression models to correlate whey protein powder characteristics to NIR data. Whey protein's ability to form gels and pullulan's electrospinnability to form nanofibers is combined herein to form blends of both that can be changed with varying concentration, pH, temperature and supplementation with food-safe additives. The study correlates mechanical properties and microstructure of blend gels and nanofibers and provides a foundation for further study of swellable network for tissue application specifically in the use of pullulan-whey protein heat treated nanofiber mats.

Various-scale controls of complex subduction dynamics on magmatic-hydrothermal processes in eastern Mediterranean

NASA Astrophysics Data System (ADS)

Menant, Armel; Jolivet, Laurent; Sternai, Pietro; Ducoux, Maxime; Augier, Romain; Rabillard, Aurélien; Gerya, Taras; Guillou-Frottier, Laurent

2014-05-01

In subduction environment, magmatic-hydrothermal processes, responsible for the emplacement of magmatic bodies and related mineralization, are strongly controlled by slab dynamics. This 3D dynamics is often complex, resulting notably in spatial evolution through time of mineralization and magmatism types and in fast kinematic changes at the surface. Study at different scales of the distribution of these magmatic and hydrothermal products is useful to better constrain subduction dynamics. This work is focused on the eastern Mediterranean, where the complex dynamics of the Tethyan active margin since the upper Cretaceous is still largely debated. We propose new kinematic reconstructions of the region also showing the distribution of magmatic products and mineralization in space and time. Three main periods have thus been identified with a general southward migration of magmatic and ore bodies. (1) From late Cretaceous to lower Paleocene, calc-alkaline magmatism and porphyry Cu deposits emplaced notably in the Balkans, along a long linear cordillera. (2) From late Paleocene to Eocene, a barren period occurred while the Pelagonian microcontinent was buried within the subduction zone. (3) Since the Oligocene, Au-rich deposits and related K-rich magmatism emplaced in the Rhodopes, the Aegean and western Anatolian extensional domains in response to fast slab retreat and related mantle flow inducing the partial melting of the lithospheric mantle or the base of the upper crust where Au was previously stored. The emplacement at shallow level of this mineralization was largely controlled by large-scale structures that drained the magmatic-hydrothermal fluids. In the Cyclades for instance, field studies show that Au-rich but also base metal-rich ore deposits are syn-extensional and spatially related to large-scale detachment systems (e.g. on Tinos, Mykonos, Serifos islands), which are recognized as subduction-related structures. These results highlight the importance at different scales of subduction dynamics and related mantle flow on the emplacement of mineralization and magmatic bodies. Indeed, besides a general southward migration of the magmatic-hydrothermal activity since the upper Cretaceous from the Balkans to the present-day Aegean volcanic arc, a secondary westward migration is observed during the Miocene from the Menderes massif to the Cyclades. This feature is a possible consequence of a slab tearing event and related mantle flow, as suggested notably by tomographic models below western Anatolia. To further test the effects of slab retreat and tearing on the flow and temperature field within the mantle, we performed 3D thermo-mechanical numerical modeling. Models suggest that the asthenospheric flow induced by the development of a slab tear controls the migration of magmatic products stored at the base of the crust, influencing the distribution of potentially fertile magmas within the upper crust.

Review of potential subsurface permeable barrier emplacement and monitoring technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Riggsbee, W.H.; Treat, R.L.; Stansfield, H.J.

1994-02-01

This report focuses on subsurface permeable barrier technologies potentially applicable to existing waste disposal sites. This report describes candidate subsurface permeable barriers, methods for emplacing these barriers, and methods used to monitor the barrier performance. Two types of subsurface barrier systems are described: those that apply to contamination.in the unsaturated zone, and those that apply to groundwater and to mobile contamination near the groundwater table. These barriers may be emplaced either horizontally or vertically depending on waste and site characteristics. Materials for creating permeable subsurface barriers are emplaced using one of three basic methods: injection, in situ mechanical mixing, ormore » excavation-insertion. Injection is the emplacement of dissolved reagents or colloidal suspensions into the soil at elevated pressures. In situ mechanical mixing is the physical blending of the soil and the barrier material underground. Excavation-insertion is the removal of a soil volume and adding barrier materials to the space created. Major vertical barrier emplacement technologies include trenching-backfilling; slurry trenching; and vertical drilling and injection, including boring (earth augering), cable tool drilling, rotary drilling, sonic drilling, jetting methods, injection-mixing in drilled holes, and deep soil mixing. Major horizontal barrier emplacement technologies include horizontal drilling, microtunneling, compaction boring, horizontal emplacement, longwall mining, hydraulic fracturing, and jetting methods.« less

Emplacement of Columbia River flood basalt

NASA Astrophysics Data System (ADS)

Reidel, Stephen P.

1998-11-01

Evidence is examined for the emplacement of the Umatilla, Wilbur Creek, and the Asotin Members of Columbia River Basalt Group. These flows erupted in the eastern part of the Columbia Plateau during the waning phases of volcanism. The Umatilla Member consists of two flows in the Lewiston basin area and southwestern Columbia Plateau. These flows mixed to form one flow in the central Columbia Plateau. The composition of the younger flow is preserved in the center and the composition of the older flow is at the top and bottom. There is a complete gradation between the two. Flows of the Wilbur Creek and Asotin Members erupted individually in the eastern Columbia Plateau and also mixed together in the central Columbia Plateau. Comparison of the emplacement patterns to intraflow structures and textures of the flows suggests that very little time elapsed between eruptions. In addition, the amount of crust that formed on the earlier flows prior to mixing also suggests rapid emplacement. Calculations of volumetric flow rates through constrictions in channels suggest emplacement times of weeks to months under fast laminar flow for all three members. A new model for the emplacement of Columbia River Basalt Group flows is proposed that suggests rapid eruption and emplacement for the main part of the flow and slower emplacement along the margins as the of the flow margin expands.

78 FR 10562 - Proposed Establishment of Area Navigation (RNAV) Routes; Washington, DC

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-14

... (VORTAC) aid and the OTTTO, VA, waypoint (WP). Q-72 would extend between the HACKS, WV, intersection and... HACKS intersection, thus reducing miles flown for RNAV-equipped aircraft. Q-80 would extend between the...., long. 078[deg]22'27'' W.) OTTTO, VA WP (Lat. 38[deg]51'16'' N., long. 078[deg]12'20'' W.) Q72 HACKS, WV...

Learning-Dependent Changes of Associations between Unfamiliar Words and Perceptual Features: A 15-Day Longitudinal Study

ERIC Educational Resources Information Center

Kambara, Toshimune; Tsukiura, Takashi; Shigemune, Yayoi; Kanno, Akitake; Nouchi, Rui; Yomogida, Yukihito; Kawashima, Ryuta

2013-01-01

This study examined behavioral changes in 15-day learning of word-picture (WP) and word-sound (WS) associations, using meaningless stimuli. Subjects performed a learning task and two recognition tasks under the WP and WS conditions every day for 15 days. Two main findings emerged from this study. First, behavioral data of recognition accuracy and…

Doppler Feature Based Classification of Wind Profiler Data

NASA Astrophysics Data System (ADS)

Sinha, Swati; Chandrasekhar Sarma, T. V.; Lourde. R, Mary

2017-01-01

Wind Profilers (WP) are coherent pulsed Doppler radars in UHF and VHF bands. They are used for vertical profiling of wind velocity and direction. This information is very useful for weather modeling, study of climatic patterns and weather prediction. Observations at different height and different wind velocities are possible by changing the operating parameters of WP. A set of Doppler power spectra is the standard form of WP data. Wind velocity, direction and wind velocity turbulence at different heights can be derived from it. Modern wind profilers operate for long duration and generate approximately 4 megabytes of data per hour. The radar data stream contains Doppler power spectra from different radar configurations with echoes from different atmospheric targets. In order to facilitate systematic study, this data needs to be segregated according the type of target. A reliable automated target classification technique is required to do this job. Classical techniques of radar target identification use pattern matching and minimization of mean squared error, Euclidean distance etc. These techniques are not effective for the classification of WP echoes, as these targets do not have well-defined signature in Doppler power spectra. This paper presents an effective target classification technique based on range-Doppler features.

[Adaptation of sensory systems of gamasid mites (Parasitiformes, Gamasina) to dwelling in different environment].

PubMed

Leonovich, S A

2008-01-01

The main complication sensory organs (the palpal organ and the tarsal sensory complex) of several species of gamasid mites were studied in scanning electron microscope. The species examined included permanent ectoparasites (Laelaps agilis, Laelaptidae), parasites of the nasal cavity and respiratory tract of birds (Sternostoma tracheocolum and Ptilonyssus reguli, Rhinonyssidae), dwellers of the sea littoral zone (Parasitus kempersi, Parasitus immanis, Parasitidae), and mites found on soil and on plants (Amblyseius barkeri, Parasitidae). Similar sensillar types, including olfactory SW-WP sensilla, contact chemo-mechanosensory (SW-UP and DW-UP) sensilla, termo-chemo-mechanosensitive (DW-WP) sensilla of two types, and tactile (NP) sensilla were found in all these species, excluding endoparasites, where some sensillar types (in particular, DW-WP sensilla with slit-like pores) are absent. It was shown that the topography of olfactory SW-WP sensilla of the tarsal complex reflects taxonomic position and phylogenetic history of mite genera, whereas the number of certain sensillar types and the degree of their development reflect ecological specialization of species. The palpal organ is characterized by rather uniform structure in mites of different families, dwellers of different environments, except for the endoparasites of the family Rhinonyssidae, where this organ is strongly reduced.

Operational experience with intermediate flat-plate photovoltaic systems

NASA Astrophysics Data System (ADS)

Risser, V. V.; Zwibel, H. S.

Operating features, data acquisition, and fault isolation and maintenance procedures at 20 kWp and 100 kWp photovoltaic (PV) installations in Texas and New Mexico are discussed. Weather and system performance are sensed each minute, averages are calculated for each ten readings, and data is stored on magnetic tape. A total of 84 parameters, including 64 string currents, are recorded at the 20 kWp array and 84 parameters, with 42 string currents, are traced in New Mexico. The 20 kW array is coupled to a 197 MW utility power plant, which determines the voltage of the array. It produced 12 MWh in one yr of operation, functioning at 24 pct overall efficiency. The 100 kWp system is coupled to a 60 kW power conditioning unit and feeds a shopping center, producing 8 pct of the annual load with a cap factor of 25 pct and 192 MWh of dc current produced in one year. It was found that under normal conditions washing the panels is not economically justified in terms of the small power lost if washing does not occur. It is concluded that the PV arrays can be successfully used in an automated operation mode.

Cloning and heterologous expression of the entire gene clusters for PD 116740 from Streptomyces strain WP 4669 and tetrangulol and tetrangomycin from Streptomyces rimosus NRRL 3016.

PubMed Central

Hong, S T; Carney, J R; Gould, S J

1997-01-01

The genes for the complete pathways for two polycyclic aromatic polyketides of the angucyclinone class have been cloned and heterologously expressed. Genomic DNAs of Streptomyces rimosus NRRL 3016 and Streptomyces strain WP 4669 were partially digested with MboI, and libraries (ca. 40-kb fragments) in Escherichia coli XL1-Blue MR were prepared with the cosmid vector pOJ446. Hybridization with the actI probe from the actinorhodin polyketide synthase genes identified two clusters of polyketide genes from each organism. After transfer of the four clusters to Streptomyces lividans TK24, expression of one cluster from each organism was established through the identification of pathway-specific products by high-performance liquid chromatography with photodiode array detection. Peaks were identified from the S. rimosus cluster (pksRIM-1) for tetrangulol, tetrangomycin, and fridamycin E. Peaks were identified from the WP 4669 cluster (pksWP-2) for tetrangulol, 19-hydroxytetrangulol, 8-O-methyltetrangulol, 19-hydroxy-8-O-methyltetrangulol, and PD 116740. Structures were confirmed by 1H nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. PMID:8990300

Cloning and heterologous expression of the entire gene clusters for PD 116740 from Streptomyces strain WP 4669 and tetrangulol and tetrangomycin from Streptomyces rimosus NRRL 3016.

PubMed

Hong, S T; Carney, J R; Gould, S J

1997-01-01

The genes for the complete pathways for two polycyclic aromatic polyketides of the angucyclinone class have been cloned and heterologously expressed. Genomic DNAs of Streptomyces rimosus NRRL 3016 and Streptomyces strain WP 4669 were partially digested with MboI, and libraries (ca. 40-kb fragments) in Escherichia coli XL1-Blue MR were prepared with the cosmid vector pOJ446. Hybridization with the actI probe from the actinorhodin polyketide synthase genes identified two clusters of polyketide genes from each organism. After transfer of the four clusters to Streptomyces lividans TK24, expression of one cluster from each organism was established through the identification of pathway-specific products by high-performance liquid chromatography with photodiode array detection. Peaks were identified from the S. rimosus cluster (pksRIM-1) for tetrangulol, tetrangomycin, and fridamycin E. Peaks were identified from the WP 4669 cluster (pksWP-2) for tetrangulol, 19-hydroxytetrangulol, 8-O-methyltetrangulol, 19-hydroxy-8-O-methyltetrangulol, and PD 116740. Structures were confirmed by 1H nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry.

Developmental palaeobiology of trilobite eyes and its evolutionary significance

NASA Astrophysics Data System (ADS)

Thomas, A. T.

2005-06-01

Understanding of the calcified composite eyes of trilobites, the oldest preserved visual system, has advanced greatly in recent decades. Three types of trilobite eye occur, the more derived abathochroal and schizochroal types having evolved neotenically from holochroal eyes. Comparative morphology and phylogenetic considerations suggest that all three eye-types were underlain by common developmental systems. So far, understanding of these systems has been based entirely on morphological data from fossils, particularly the way the visual surface grew and the patterning of lens emplacement. Lenses characteristically form a hexagonal array comprising horizontal rows and, conspicuously in schizochroal eyes, dorso-ventral files. Because individual trilobites sometimes have eyes with different numbers of files, file number must reflect the operation of a developmental programme rather than being under immediate genetic control. An empirical developmental model has been devised to describe trilobite eye development, with separate rules dealing with the initiation of lens emplacement, growth and differentiation of the visual surface, and the termination of lens emplacement. Rarely, trilobites may have visual surfaces of normal size, but which lack lenses. This confirms that visual surface growth must have been regulated separately from lens emplacement, and is a feature that cannot be accounted for by the existing developmental model. Such a developmental separation is one of a number of similarities shared with Drosophila, the modern arthropod in which eye development is best understood. Many aspects of eye development are conserved in the Euarthropoda, and in bilaterian metazoans in general. A revised model for trilobite eye development is proposed using extant phylogenetic bracketing, interpreting morphological data from the fossils in the context of the hierarchy of developmental controls now becoming known from living animals. This new model suggests that overall eye shape and size did not require differential growth of the generative zone, as previously thought, and that no separate instruction was needed to specify the termination of lens emplacement. Instead, these features were regulated directly, by controlling the proliferation of cells making up the nascent visual surface. A process documented from Drosophila, which involves the selective inhibition of cells in front of a wave-like front of differentiation, and that is regulated by widely conserved genes, can be used to explain how the trilobite visual surface became differentiated. The model implies also that changes in hormonally regulated developmental pathways known from recent arthropods may have been responsible for the development of abathochroal and schizochroal eyes, and for heterochronic secondary eye reduction and blindness in trilobites.

Using analog flow experiments to model morphologies developed during episodic dome growth: A case study of Mount St Helens, 1980-1986

NASA Astrophysics Data System (ADS)

Altman, K. M.; Teasdale, R.

2009-12-01

From 1980 to 1986 the dacite dome at Mount St. Helens was emplaced as a series of 17 events, identified by different growth rates, volumes, height to diameter ratios, emplacement rates, surface textures and dome morphologies (Swanson, 1989). Rates of emplacement characterize three periods; between October 18, 1980 and the end of 1981 the growth rate was 1.8 x 10^6 m^3/month; between March 1982 and March 1984 the growth rate was 1.3 x 10^6 m^3/month; followed by a growth rate of 0.62 x 10^6 m^3/month until the end of the emplacement events in 1986 (Swanson, 1989). The shape of the dome changed from 1980 to 1986 as a function of magma viscosity, tensile strength of the hot core, and thickness of the outer shell (Swanson, 1989). The height to diameter ratios (h:d) recorded throughout the growth of the dome have been used to quantify the changes in the shape of the dome. The dome was flatter during the first period of emplacement when larger volumes kept the dome hotter and hindered the formation of a thick, cool outer crust (Swanson, 1989). Once the growth rate slowed by June 1981, a thick skin had formed and allowed the dome to steepen (Swanson, 1989). Analog models presented here aim to reproduce the emplacement of the domes based on observations and data recorded at Mount St. Helens from 1980 to 1986. Flow experiments use a slurry of PEG (poly-ethelyne glycol) mixed with kaolin powder that is pumped into a tank of cold water (Fink and Griffiths, 1998). PEG is used because it is liquid at room temperature and solidifies in the cold water. Kaolin powder is added to the PEG to simulate the viscosity of the dacite domes. The observed and recorded data from Mount St. Helens are used to constrain analog flow model parameters such as slope, effusion rate, and PEG viscosity in an attempt to recreate the dome morphologies observed in the 1980 to 1986 episodes. As expected, dome morphology in experiments varies with the crustal thickness developed during experiments. The thickness of dome crust increases when the difference between water temperature and the slurry are large. Dome crust thickness controls the h:d ratio, which are used here to characterize dome morphology. The h:d ratio of experiments are within 5% of those measured at Mount St. Helens, so are considered good representations of dome growth events. Ongoing work investigates multiple episodes of dome emplacement using solid structures in the tanks to represent previously emplaced dome edifices.

Free-standing ternary NiWP film for efficient water oxidation reaction

NASA Astrophysics Data System (ADS)

Yang, Yunpeng; Zhou, Kuo; Ma, Lili; Liang, Yanqin; Yang, Xianjin; Cui, Zhenduo; Zhu, Shengli; Li, Zhaoyang

2018-03-01

High-efficient catalysts for oxygen evolution reaction (OER) is of great concern in improving energy efficiency for water splitting. Here we report a high-performance OER electrocatalyst of nickel-tungsten-phosphorus (NiWP) film prepared by template method. This free-standing ternary electrocatalyst exhibits a remarkable electrocatalytic activity of OER in alkaline medium due to the synergetic effect among these elements and the good electrical conductivity. The reported NiWP composite catalyst has an overpotential of as low as 0.4 V (vs. RHE) at 30 mA cm-2, better than that of the commercial RuO2 catalyst. Moreover, a small charge transfer resistance of 4.06 Ω and a Tafel slope of 68 mV dec-1 demonstrate the outstanding catalytic activity.

Mutagenicity of benzotrichloride and related compounds.

PubMed

Yasuo, K; Fujimoto, S; Katoh, M; Kikuchi, Y; Kada, T

1978-11-01

Benzotrichloride (BTC), benzal chloride (BDC), benzyl chloride (BC) and benzoyl chloride (BOC) were surveyed for their mutagenicity in microbial systems such as rec-assay using Bacillus subtilis and reversion assays using E. coli WP2 and Ames Salmonella TA strains with or without metabolic activation in vitro. BTC and BDC required metabolic activation for their mutagenic activities in several strains of E. coli and Salmonella. The mutagenic metabolites of these compounds may not have been produced by hydrolysis. BC was weakly mutagenic without metabolic activation. Only BOC exhibited no mutagenic activity in the detection procedures used. The mutagenic metabolite of BTC might be very unstable under our experimental conditions. The strain E. coli WP2 try hcr was more sensitive than E. coli B/r WP2 try (hcr+) with regard to the mutagenicity of BTC.

Planck constraints on holographic dark energy

NASA Astrophysics Data System (ADS)

Li, Miao; Li, Xiao-Dong; Ma, Yin-Zhe; Zhang, Xin; Zhang, Zhenhui

2013-09-01

We perform a detailed investigation on the cosmological constraints on the holographic dark energy (HDE) model by using the Plank data. We find that HDE can provide a good fit to the Plank high-l (l gtrsim 40) temperature power spectrum, while the discrepancy at l simeq 20-40 found in the ΛCDM model remains unsolved in the HDE model. The Plank data alone can lead to strong and reliable constraint on the HDE parameter c. At the 68% confidence level (CL), we obtain c = 0.508 ± 0.207 with Plank+WP+lensing, favoring the present phantom behavior of HDE at the more than 2σ CL. By combining Plank+WP with the external astrophysical data sets, i.e. the BAO measurements from 6dFGS+SDSS DR7(R)+BOSS DR9, the direct Hubble constant measurement result (H0 = 73.8 ± 2.4 kms-1Mpc-1) from the HST, the SNLS3 supernovae data set, and Union2.1 supernovae data set, we get the 68% CL constraint results c = 0.484 ± 0.070, 0.474 ± 0.049, 0.594 ± 0.051, and 0.642 ± 0.066, respectively. The constraints can be improved by 2%-15% if we further add the Plank lensing data into the analysis. Compared with the WMAP-9 results, the Plank results reduce the error by 30%-60%, and prefer a phantom-like HDE at higher significant level. We also investigate the tension between different data sets. We find no evident tension when we combine Plank data with BAO and HST. Especially, we find that the strong correlation between Ωmh3 and dark energy parameters is helpful in relieving the tension between the Plank and HST measurements. The residual value of χ2Plank+WP+HST-χ2Plank+WP is 7.8 in the ΛCDM model, and is reduced to 1.0 or 0.3 if we switch the dark energy to w model or the holographic model. When we introduce supernovae data sets into the analysis, some tension appears. We find that the SNLS3 data set is in tension with all other data sets; for example, for the Plank+WP, WMAP-9 and BAO+HST, the corresponding Δχ2 is equal to 6.4, 3.5 and 4.1, respectively. As a comparison, the Union2.1 data set is consistent with these three data sets, but the combination Union2.1+BAO+HST is in tension with Plank+WP+lensing, corresponding to a large Δχ2 that is equal to 8.6 (1.4% probability). Thus, combining internal inconsistent data sets (SNIa+BAO+HST with Plank+WP+lensing) can lead to ambiguous results, and it is necessary to perform the HDE data analysis for each independent data sets. Our tightest self-consistent constraint is c = 0.495 ± 0.039 obtained from Plank+WP+BAO+HST+lensing.

Admixture enhanced controlled low-strength material for direct underwater injection with minimal cross-contamination

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hepworth, H.K.; Davidson, J.S.; Hooyman, J.L.

1997-03-01

Commercially available admixtures have been developed for placing traditional concrete products under water. This paper evaluates adapting anti-washout admixture (AWA) and high range water reducing admixture (HRWRA) products to enhance controlled low-strength materials (CLSMs) for underwater placement. A simple experimental scale model (based on dynamic and geometric similitude) of typical grout pump emplacement equipment has been developed to determine the percentage of cementing material washed out. The objective of this study was to identify proportions of admixtures and underwater CLSM emplacement procedures which would minimize the cross-contamination of the displaced water while maintaining the advantages of CLSM. Since the displacedmore » water from radioactively contaminated systems must be subsequently treated prior to release to the environment, the amount of cross-contamination is important for cases in which cementing material could form hard sludges in a water treatment facility and contaminate the in-place CLSM stabilization medium.« less

Infrastructure for deployment of power systems

NASA Technical Reports Server (NTRS)

Sprouse, Kenneth M.

1991-01-01

A preliminary effort in characterizing the types of stationary lunar power systems which may be considered for emplacement on the lunar surface from the proposed initial 100-kW unit in 2003 to later units ranging in power from 25 to 825 kW is presented. Associated with these power systems are their related infrastructure hardware including: (1) electrical cable, wiring, switchgear, and converters; (2) deployable radiator panels; (3) deployable photovoltaic (PV) panels; (4) heat transfer fluid piping and connection joints; (5) power system instrumentation and control equipment; and (6) interface hardware between lunar surface construction/maintenance equipment and power system. This report: (1) presents estimates of the mass and volumes associated with these power systems and their related infrastructure hardware; (2) provides task breakdown description for emplacing this equipment; (3) gives estimated heat, forces, torques, and alignment tolerances for equipment assembly; and (4) provides other important equipment/machinery requirements where applicable. Packaging options for this equipment will be discussed along with necessary site preparation requirements. Design and analysis issues associated with the final emplacement of this power system hardware are also described.

Therapeutic experiences of community gardens: putting flow in its place.

PubMed

Pitt, Hannah

2014-05-01

This paper develops the concept of therapeutic place experiences by considering the role of activity. Research of community gardening finds that particular tasks are therapeutic and exhibit the characteristics of flow, but those who lack influence over their community gardening are less likely to benefit from flow as their sense of control is reduced. The notion of emplaced flow is proposed to locate individual experiences amongst socio-spatial factors which limit self-determinacy and therefore affect wellbeing. Emplacing flow prompts critical reflection on who is excluded from therapeutic place experiences, and whether sites offering momentary escape have an enduring impact on wellbeing. Copyright © 2014 Elsevier Ltd. All rights reserved.

Space Station Freedom primary power wiring requirements

NASA Technical Reports Server (NTRS)

Hill, Thomas J.

1994-01-01

The Space Station Freedom (SSF) Program requirements are a 30 year reliable service life in low Earth orbit in hard vacuum or pressurized module service without detrimental degradation. Specific requirements are outlined in this presentation for SSF primary power and cable insulation. The primary power cable status and the WP-4 planned cable test program are also reviewed along with Rocketdyne-WP04 prime insulation candidates.

Workshop Physics and Related Curricula: "A 25-Year History of Collaborative Learning Enhanced by Computer Tools for Observation and Analysis"

ERIC Educational Resources Information Center

Laws, Priscilla W.; Willis, Maxine C.; Sokoloff, David R.

2015-01-01

This article describes the 25-year history of development of the activity-based Workshop Physics (WP) at Dickinson College, its adaptation for use at Gettysburg Area High School, and its synergistic influence on curricular materials developed at the University of Oregon and Tufts University and vice versa. WP and these related curricula: 1) are…

Intensity-modulated radiotherapy improves lymph node coverage and dose to critical structures compared with three-dimensional conformal radiation therapy in clinically localized prostate cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang-Chesebro, Alice; Xia Ping; Coleman, Joy

2006-11-01

Purpose: The aim of this study was to quantify gains in lymph node coverage and critical structure dose reduction for whole-pelvis (WP) and extended-field (EF) radiotherapy in prostate cancer using intensity-modulated radiotherapy (IMRT) compared with three-dimensional conformal radiotherapy (3DCRT) for the first treatment phase of 45 Gy in the concurrent treatment of lymph nodes and prostate. Methods and Materials: From January to August 2005, 35 patients with localized prostate cancer were treated with pelvic IMRT; 7 had nodes defined up to L5-S1 (Group 1), and 28 had nodes defined above L5-S1 (Group 2). Each patient had 2 plans retrospectively generated:more » 1 WP 3DCRT plan using bony landmarks, and 1 EF 3DCRT plan to cover the vascular defined volumes. Dose-volume histograms for the lymph nodes, rectum, bladder, small bowel, and penile bulb were compared by group. Results: For Group 1, WP 3DCRT missed 25% of pelvic nodes with the prescribed dose 45 Gy and missed 18% with the 95% prescribed dose 42.75 Gy, whereas WP IMRT achieved V{sub 45Gy} = 98% and V{sub 42.75Gy} = 100%. Compared with WP 3DCRT, IMRT reduced bladder V{sub 45Gy} by 78%, rectum V{sub 45Gy} by 48%, and small bowel V{sub 45Gy} by 232 cm{sup 3}. EF 3DCRT achieved 95% coverage of nodes for all patients at high cost to critical structures. For Group 2, IMRT decreased bladder V{sub 45Gy} by 90%, rectum V{sub 45Gy} by 54% and small bowel V{sub 45Gy} by 455 cm{sup 3} compared with EF 3DCRT. Conclusion: In this study WP 3DCRT missed a significant percentage of pelvic nodes. Although EF 3DCRT achieved 95% pelvic nodal coverage, it increased critical structure doses. IMRT improved pelvic nodal coverage while decreasing dose to bladder, rectum, small bowel, and penile bulb. For patients with extended node involvement, IMRT especially decreases small bowel dose.« less

Mental and Emotional Impairment in Patients With Hepatitis C is Related to Lower Work Productivity.

PubMed

Younossi, Issah; Weinstein, Ali; Stepanova, Maria; Hunt, Sharon; Younossi, Zobair M

2016-01-01

Patients with Hepatitis C virus (HCV) have a higher risk of developing mental and emotional health (MEH) issues compared with the general population. Our aim was to assess the relationship between MEH and work productivity (WP) in patients with HCV. Patients with HCV enrolled in multinational clinical trials completed 4 questionnaires (Short Form 36 [SF-36], the Functional Assessment of Chronic Illness Therapy-Fatigue [FACIT-F], Chronic Liver Disease Questionnaire-Hepatitis C Virus [CLDQ-HCV], and the WP and Activity-Specific Health Problem [WPAI:SHP]) while they were not under treatment. The emotional domain (EM) of CLDQ-HCV, the role emotional, mental health, and the mental summary score of the SF-36 were used as the MEH indicators. We compared patients with an EM score of less than 4.66 (range: 1-7), which is the lowest quartile of emotional health, and those with an EM score of more than 6.33, which is the topmost quartile. A total of 4333 patients were enrolled. Of those, 3,888 had MEH issues and WP data available. Patients were 52.3 ± 9.9 years old, 65.8% of them were male, 63.7% were treatment naïve, 19.7% were cirrhotic, 29.0% reported having a history of depression, and 18.7% had a history of anxiety. Patients at the top quartile of the EM were older, were more likely to be men, had less anxiety and depression, and were less likely to be cirrhotic and fatigued, but they were more likely to be employed as compared with the patients at the lowest quartile of the EM domain (all p < 0.0001). Furthermore, these patients had less WP impairment (0.023 ± 0.101 vs. 0.310 ± 0.288, p < 0.05). Multivariate regression analysis revealed that RE and EM were both predictive of WP scores (all p < 0.0001), presenteeism, and absenteeism (all p < 0.003). In patients with HCV, impairment in MEH is predictive of lower WP. Copyright © 2016 The Academy of Psychosomatic Medicine. Published by Elsevier Inc. All rights reserved.

Realist Evaluation of the Use of Patient Experience Data to Improve the Quality of Inpatient Mental Health Care (EURIPIDES) in England: study protocol.

PubMed

Weich, Scott; Fenton, Sarah-Jane Hannah; Bhui, Kamaldeep; Staniszewska, Sophie; Madan, Jason; Larkin, Michael; Newton, Elizabeth; Crepaz-Keay, David; Canaway, Alastair; Croft, Charlotte; Griffiths, Frances

2018-06-14

Inpatient mental healthcare continues to be an area of high risk and where patients report negative experiences. To ensure the patient voice is heard, National Health Service (NHS) Trusts are required to collect feedback from patients routinely. We do not know what kinds of feedback are most important or what management processes are needed to translate this into effective action plans. Further, we do not know if this makes any difference to the patients themselves. This study seeks to explore which of the many different approaches to collecting and using patient experience data are the most useful for supporting improvements in inpatient mental healthcare. The overarching aim of the study is to arrive at recommendations for best practice in the collection and use of patient experience data in NHS England adult inpatient mental health settings. We present the protocol for Realist Evaluation of the Use of Patient Experience Data to Improve the Quality of Inpatient Mental Health Care study (EURIPIDES). The study is composed of five work packages (WPs), including a systematic review of patient experiences (WP1); a telephone survey to assist the selection of case sites (WP2); six indepth case studies involving interviews with service users, carers and staff to enable a realist evaluation of the use of patient experience to improve quality in adult inpatient mental health services (WP3); an economic evaluation of patient experience feedback activity (WP5); and a consensus conference (WP4). We discuss the methodological rationale for the five WPs. This study has received approval from West Midlands/South Birmingham NHS Research Ethics Committee. The outcome of the consensus conference meeting (WP4) will form the basis of the outputs to be disseminated to NHS providers. Dissemination will also take place through publications and presentations at relevant conferences. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Challenges in the Development and Evolution of Secure Open Architecture Command and Control Systems (Briefing Charts)

DTIC Science & Technology

2013-06-01

widgets for an OA system Design-time architecture: Browser, email, widget, DB, OS Go ogle Instance architecture: Chrome, Gmail, Google...provides functionally similar components or applications compatible with an OA system design Firefox Browser, WP, calendar Opera Instance...architecture: Firefox , AbiWord, Evolution, Fedora GPL Ab1Word Google Docs Instance ardlitecture: Fire fox, OR Google cal., Google Docs, Fedora

A New Technique Using Low Volumes: A New Technique to Assess the Molluscicidal Activity Using Low Volumes.

PubMed

Santos, José Augusto Albuquerque; Cavalcante, Viviane Paixão; Rangel, Leonardo da Silva; Leite, João Claudio Vitória Atico; Faria, Robson Xavier

2017-01-01

Schistosomiasis is a disease endemic in several states of Brazil. The population control of the transmitter mollusks is done with Bayluscide WP 70®, in the control programs. OMS preconize molluscicidal assays using Becker with 500 mL of final volume, restringing the number of natural products and synthetic drugs to be tested in function of high quantity of material necessary. A new technique to assess the toxic effects for Biomphalaria sp. is the purpose of this work, for developing adaptation for this aquatic organism, using a low volume of test solution in 24-well plates. We used Biomphalaria glabrata (10-12 mm size) in a static system, consisting of the following components: Becker containing 10 snails or 24-well plates where snails were individualized for a volume of 2 mL per well for 24 and 48 hours. For the assays, we added aqueous solutions of Bayluscide WP 70, at a concentration of 1-5 mg/L, distilled water, and 1% dimethyl sulfoxide. Data were evaluated using Kappa's coefficient, Z factor validation, and comparison study. This technique to assess the toxic effect has proven to be a useful tool to detect lethal and sublethal effects, which could be used as a new evaluation protocol.

A New Technique Using Low Volumes: A New Technique to Assess the Molluscicidal Activity Using Low Volumes

PubMed Central

Cavalcante, Viviane Paixão; Rangel, Leonardo da Silva; Leite, João Claudio Vitória Atico

2017-01-01

Schistosomiasis is a disease endemic in several states of Brazil. The population control of the transmitter mollusks is done with Bayluscide WP 70®, in the control programs. OMS preconize molluscicidal assays using Becker with 500 mL of final volume, restringing the number of natural products and synthetic drugs to be tested in function of high quantity of material necessary. A new technique to assess the toxic effects for Biomphalaria sp. is the purpose of this work, for developing adaptation for this aquatic organism, using a low volume of test solution in 24-well plates. We used Biomphalaria glabrata (10–12 mm size) in a static system, consisting of the following components: Becker containing 10 snails or 24-well plates where snails were individualized for a volume of 2 mL per well for 24 and 48 hours. For the assays, we added aqueous solutions of Bayluscide WP 70, at a concentration of 1–5 mg/L, distilled water, and 1% dimethyl sulfoxide. Data were evaluated using Kappa's coefficient, Z factor validation, and comparison study. This technique to assess the toxic effect has proven to be a useful tool to detect lethal and sublethal effects, which could be used as a new evaluation protocol. PMID:28951760

Controls on Lava Flow Morphology and Propagation: Using Laboratory Analogue Experiments

NASA Astrophysics Data System (ADS)

Peters, S.; Clarke, A. B.

2017-12-01

The morphology of lava flows is controlled by eruption rate, composition, cooling rate, and topography [Fink and Griffiths, 1990; Gregg and Fink, 2000, 2006]. Lava flows are used to understand how volcanoes, volcanic fields, and igneous provinces formed and evolved [Gregg and Fink., 1996; Sheth, 2006]. This is particularly important for other planets where compositional data is limited and historical context is nonexistent. Numerical modeling of lava flows remains challenging, but has been aided by laboratory analog experiments [Gregg and Keszrthelyi, 2004; Soule and Cashman, 2004]. Experiments using polyethylene glycol (PEG) 600 wax have been performed to understand lava flow emplacement [Fink and Griffiths, 1990, 1992; Gregg and Fink, 2000]. These experiments established psi (hereafter denoted by Ψ), a dimensionless parameter that relates crust formation and advection timescales of a viscous gravity current. Four primary flow morphologies corresponding to discreet Ψ ranges were observed. Gregg and Fink [2000] also investigated flows on slopes and found that steeper slopes increase the effective effusion rate producing predicted morphologies at lower Ψ values. Additional work is needed to constrain the Ψ parameter space, evaluate the predictive capability of Ψ, and determine if the preserved flow morphology can be used to indicate the initial flow conditions. We performed 514 experiments to address the following controls on lava flow morphology: slope (n = 282), unsteadiness/pulsations (n = 58), slope & unsteadiness/pulsations (n = 174), distal processes, and emplacement vs. post-emplacement morphologies. Our slope experiments reveal a similar trend to Gregg and Fink [2000] with the caveat that very high and very low local & source eruption rates can reduce the apparent predictive capability of Ψ. Predicted Ψ morphologies were often produced halfway through the eruption. Our pulse experiments are expected to produce morphologies unique to each eruption rate and promote tube formation and compound flows. Post-emplacement morphologies are modified by a variety of factors (e.g. solidification, deflation), which may not preserve the initial morphology produced during an eruption. Relating this morphology to the eruption conditions is pertinent to understanding the evolution of planetary surfaces.

Compositional Control of the Mixed Anion Alloys in Gallium-Free InAs/InAsSb Superlattice Materials for Infrared Sensing (Postprint)

DTIC Science & Technology

2015-08-28

AFRL-RX-WP-JA-2016-0251 COMPOSITIONAL CONTROL OF THE MIXED ANION ALLOYS IN GALLIUM -FREE InAs/InAsSb SUPERLATTICE MATERIALS FOR...ANION ALLOYS IN GALLIUM -FREE InAs/InAsSb SUPERLATTICE MATERIALS FOR INFRARED SENSING (POSTPRINT) 5a. CONTRACT NUMBER FA8650-07-D-5800-0006 5b...proceedings.spiedigitallibrary.org doi: 10.1117/12.2186188 14. ABSTRACT (Maximum 200 words) Gallium (Ga)-free InAs/InAsSb superlattices (SLs) are being actively explored for

Seismic Risk Assessment and Loss Estimation for Tbilisi City

NASA Astrophysics Data System (ADS)

Tsereteli, Nino; Alania, Victor; Varazanashvili, Otar; Gugeshashvili, Tengiz; Arabidze, Vakhtang; Arevadze, Nika; Tsereteli, Emili; Gaphrindashvili, Giorgi; Gventcadze, Alexander; Goguadze, Nino; Vephkhvadze, Sophio

2013-04-01

The proper assessment of seismic risk is of crucial importance for society protection and city sustainable economic development, as it is the essential part to seismic hazard reduction. Estimation of seismic risk and losses is complicated tasks. There is always knowledge deficiency on real seismic hazard, local site effects, inventory on elements at risk, infrastructure vulnerability, especially for developing countries. Lately great efforts was done in the frame of EMME (earthquake Model for Middle East Region) project, where in the work packages WP1, WP2 , WP3 and WP4 where improved gaps related to seismic hazard assessment and vulnerability analysis. Finely in the frame of work package wp5 "City Scenario" additional work to this direction and detail investigation of local site conditions, active fault (3D) beneath Tbilisi were done. For estimation economic losses the algorithm was prepared taking into account obtained inventory. The long term usage of building is very complex. It relates to the reliability and durability of buildings. The long term usage and durability of a building is determined by the concept of depreciation. Depreciation of an entire building is calculated by summing the products of individual construction unit' depreciation rates and the corresponding value of these units within the building. This method of calculation is based on an assumption that depreciation is proportional to the building's (constructions) useful life. We used this methodology to create a matrix, which provides a way to evaluate the depreciation rates of buildings with different type and construction period and to determine their corresponding value. Finally loss was estimated resulting from shaking 10%, 5% and 2% exceedance probability in 50 years. Loss resulting from scenario earthquake (earthquake with possible maximum magnitude) also where estimated.

Identification of three wheat globulin genes by screening a Triticum aestivum BAC genomic library with cDNA from a diabetes-associated globulin

PubMed Central

Loit, Evelin; Melnyk, Charles W; MacFarlane, Amanda J; Scott, Fraser W; Altosaar, Illimar

2009-01-01

Background Exposure to dietary wheat proteins in genetically susceptible individuals has been associated with increased risk for the development of Type 1 diabetes (T1D). Recently, a wheat protein encoded by cDNA WP5212 has been shown to be antigenic in mice, rats and humans with autoimmune T1D. To investigate the genomic origin of the identified wheat protein cDNA, a hexaploid wheat genomic library from Glenlea cultivar was screened. Results Three unique wheat globulin genes, Glo-3A, Glo3-B and Glo-3C, were identified. We describe the genomic structure of these genes and their expression pattern in wheat seeds. The Glo-3A gene shared 99% identity with the cDNA of WP5212 at the nucleotide and deduced amino acid level, indicating that we have identified the gene(s) encoding wheat protein WP5212. Southern analysis revealed the presence of multiple copies of Glo-3-like sequences in all wheat samples, including hexaploid, tetraploid and diploid species wheat seed. Aleurone and embryo tissue specificity of WP5212 gene expression, suggested by promoter region analysis, which demonstrated an absence of endosperm specific cis elements, was confirmed by immunofluorescence microscopy using anti-WP5212 antibodies. Conclusion Taken together, the results indicate that a diverse group of globulins exists in wheat, some of which could be associated with the pathogenesis of T1D in some susceptible individuals. These data expand our knowledge of specific wheat globulins and will enable further elucidation of their role in wheat biology and human health. PMID:19615078

A lattice Boltzmann investigation of steady-state fluid distribution, capillary pressure and relative permeability of a porous medium: Effects of fluid and geometrical properties

NASA Astrophysics Data System (ADS)

Li, Zi; Galindo-Torres, Sergio; Yan, Guanxi; Scheuermann, Alexander; Li, Ling

2018-06-01

Simulations of simultaneous steady-state two-phase flow in the capillary force-dominated regime were conducted using the state-of-the-art Shan-Chen multi-component lattice Boltzmann model (SCMC-LBM) based on two-dimensional porous media. We focused on analyzing the fluid distribution (i.e., WP fluid-solid, NP fluid-solid and fluid-fluid interfacial areas) as well as the capillary pressure versus saturation curve which was affected by fluid and geometrical properties (i.e., wettability, adhesive strength, pore size distribution and specific surface area). How these properties influenced the relative permeability versus saturation relation through apparent effective permeability and threshold pressure gradient was also explored. The SCMC-LBM simulations showed that, a thin WP fluid film formed around the solid surface due to the adhesive fluid-solid interaction, resulting in discrete WP fluid distributions and reduction of the WP fluid mobility. Also, the adhesive interaction provided another source of capillary pressure in addition to capillary force, which, however, did not affect the mobility of the NP fluid. The film fluid effect could be enhanced by large adhesive strength and fine pores in heterogeneous porous media. In the steady-state infiltration, not only the NP fluid but also the WP fluid were subjected to the capillary resistance. The capillary pressure effect could be alleviated by decreased wettability, large average pore radius and improved fluid connectivity in heterogeneous porous media. The present work based on the SCMC-LBM investigations elucidated the role of film fluid as well as capillary pressure in the two-phase flow system. The findings have implications for ways to improve the macroscopic flow equation based on balance of force for the steady-state infiltration.

Isolation, characterization and identification of pericarp-degrading bacteria for the production of off-odour-free white pepper from fresh berries of Piper nigrum L.

PubMed

Vinod, V; Kumar, A; Zachariah, T J

2014-04-01

To isolate, fermentatively evaluate and identify black pepper (Piper nigrum L.)-associated bacteria for the microbial decortication of fresh ripened berries and dried black pepper for preparation of off-odour-free white pepper. Among 45 bacterial isolates obtained from black pepper, seven of them were found to decorticate black pepper (>60%) and fresh pepper berries (98-100%) into white pepper within 5 days of immersion in bacterial suspension. The 16S rRNA genes (1500-bp amplicon) of these bacteria were sequenced, and species identity was established by closest match in GenBank. Superior-quality white pepper was obtained with Bacillus subtilis (IISR WP 33, 34, 38), Bacillus licheniformis (IISR WP 43), Acinetobacter baumanii (IISR WP 35), Klebsiella pneumoniae (IISR WP 19) and Microbacterium barkeri (IISR WP25). The bacterial isolates were found to secrete multiple hydrolytic enzymes such as cellulase, pectinase, amylase, protease and xylanase. Bacterial cultures were deposited with International Depository Authority at Microbial Type Culture Collection, India, as patent deposits as prescribed in Budapest Treaty for microbial deposits. The white pepper, thus obtained from bacterial decortication process, was free from off-odour compound, especially skatole. Other biochemical constituents such as oleoresin, piperine and essential oils were found in the acceptable range. The bacterial decortication did not affect inherent constituents of pepper such as essential oil constituents, oleoresin and piperine content. One of the most significant findings of the work is identification of specific bacterial species for decortication of fresh berries or black pepper berries into value-added white pepper. This work paved way for developing a technological process for microbial decortication of fresh/black pepper for the production of superior-quality white pepper. © 2014 The Society for Applied Microbiology.

Comparison of copepod collection efficiencies by three commonly used plankton nets: A case study in Bohai Sea, China

NASA Astrophysics Data System (ADS)

Chen, Hongju; Yu, Hao; Liu, Guangxing

2016-12-01

Selection of net with a suitable mesh size is a key concern in the quantitative assessment of zooplankton, which is crucial to understand pelagic ecosystem processes. This study compared the copepod collecting efficiency of three commonly used plankton nets, namely, the China standard coarse net (505 μm mesh), the China standard fine net (77 μm), and the WP-2 net (200 μm). The experiment was performed at six stations in the Bohai Sea during the autumn of 2012. The coarse net substantially under-sampled small individuals (body widths < 672 μm) and led to the lowest species number in each tow, whereas the fine net collected all small copepod species but failed to collect rare species. The WP-2 net appeared to be a compromise of the two other nets, collecting both small copepods and rare species. The abundance of copepods collected by the coarse net (126.4 ± 86.5 ind m-3) was one to two orders of magnitude lower than that by the WP-2 net (5802.4 ± 2595.4 ind m-3), and the value of the fine net (11117.0 ± 4563.41 ind m-3) was nearly twice that of the WP-2 net. The abundance of large copepods ( i.e., adult Calanus sinicus) in the three nets showed no significant differences, but the abundance of small copepods declined with decreasing mesh size. The difference in abundance resulted from the under-sampling of small copepods with body widths < 672 μm and < 266 μm by the coarse and WP-2 nets, respectively.

Basic investigation of the laminated alginate impression technique: Setting time, permanent deformation, elastic deformation, consistency, and tensile bond strength tests.

PubMed

Kitamura, Aya; Kawai, Yasuhiko

2015-01-01

Laminated alginate impression for edentulous is simple and time efficient compared to border molding technique. The purpose of this study was to examine clinical applicability of the laminated alginate impression, by measuring the effects of different Water/Powder (W/P) and mixing methods, and different bonding methods in the secondary impression of alginate impression. Three W/P: manufacturer-designated mixing water amount (standard), 1.5-fold (1.5×) and 1.75-fold (1.75×) water amount were mixed by manual and automatic mixing methods. Initial and complete setting time, permanent and elastic deformation, and consistency of the secondary impression were investigated (n=10). Additionally, tensile bond strength between the primary and secondary impression were measured in the following surface treatment; air blow only (A), surface baking (B), and alginate impression material bonding agent (ALGI-BOND: AB) (n=12). Initial setting times significantly shortened with automatic mixing for all W/P (p<0.05). The permanent deformation decreased and elastic deformation increased as high W/P, regardless of the mixing method. Elastic deformation significantly reduced in 1.5× and 1.75× with automatic mixing (p<0.05). All of these properties resulted within JIS standards. For all W/P, AB showed a significantly high bonding strength as compared to A and B (p<0.01). The increase of mixing water, 1.5× and 1.75×, resulted within JIS standards in setting time, suggesting its applicability in clinical setting. The use of automatic mixing device decreased elastic strain and shortening of the curing time. For the secondary impression application of adhesives on the primary impression gives secure adhesion. Copyright © 2014 Japan Prosthodontic Society. Published by Elsevier Ltd. All rights reserved.

Impact of pharmacists assisting with prescribing and undertaking medication review on oxycodone prescribing and supply for patients discharged from surgical wards.

PubMed

Tran, T; Taylor, S E; Hardidge, A; Findakly, D; Aminian, P; Elliott, R A

2017-10-01

Overprescribing of oxycodone is a contributor to the epidemic of prescription opioid misuse and deaths. Practice models to optimize oxycodone prescribing and supply need to be evaluated. We explored the impact of pharmacist-assisted discharge prescribing and medication review on oxycodone prescribing and supply for patients discharged from surgical wards. A retrospective audit was conducted on two surgical inpatient wards following a 16-week prospective pre- and post-intervention study. During the pre-intervention period, discharge prescriptions were prepared by hospital doctors and then reviewed by a ward pharmacist (WP) before being dispensed. Post-intervention, prescriptions were prepared by a project pharmacist in consultation with hospital doctors and then reviewed by a WP and dispensed. Proportion of patients who were prescribed, and proportion supplied, oxycodone on discharge; Median amount (milligrams) of oxycodone prescribed and supplied, for patients who were prescribed and supplied at least one oxycodone-containing preparation, respectively. A total of 320 and 341 patients were evaluated pre- and post-intervention, respectively. Pre-intervention, 75.6% of patients were prescribed oxycodone; after WP review, 60.3% were supplied oxycodone (P<.01); the median amount both prescribed and supplied was 100 milligrams/patient. Post-intervention, 68.6% of patients were prescribed oxycodone; after WP review, 57.8% were supplied oxycodone (P<.01); median amount prescribed and supplied was 50 milligrams/patient (difference in amount prescribed and supplied: 50 milligrams, P<.01). WP review of doctor-prepared prescriptions reduced the proportion of patients who were supplied oxycodone but not the amount supplied/patient. Having a pharmacist assist with prescribing reduced the amount of oxycodone supplied. © 2017 John Wiley & Sons Ltd.

Annual variability of water productivity components in the watershed of Cabeceira Comprida stream, Santa Fé do Sul, Brazil

NASA Astrophysics Data System (ADS)

Coaguila, Daniel N.; Hernandez, Fernando B. T.; de C. Teixeira, Antônio H.; Neale, Christopher M.; Franco, Renato A. M.; Leivas, Janice F.

2016-10-01

The Cabeceira Comprida stream's watershed, located in Santa Fé do Sul, Brazil, is an agroecosystem with great demand of water for the population and agriculture. During the dry season the water demand exceeds the amount generated by the watershed. It is important to know the dynamics of the water above the ground to improve the water resources management. Ten Landsat 8 images were used combined with Northwestern São Paulo State Weather Network data under different thermohydrological conditions of the year 2014 to quantify actual evapotranspiration (ETa), biomass production (BIO) and water productivity (WP) based on ETa. Using the Simple Algorithm for Retrieving evapotranspiration (SAFER) for calculating ETa, the Monteith's radiation model was applied for estimating the BIO and for calculation of WP the ratio of BIO and ETa. The average pixels for ETa, BIO and WP ranged respectively from 0.38 +/- 0.35 to 2.05 +/- 0.76 mm day-1; 10.15 +/- 12.19 to 71.61 +/- 35.54 kg ha-1 day-1; 1.89 +/- 0.76 to 3.88 +/- 0.86 kg m-3. The lower values of ETa (0.38 mm day-1; DOY 220), BIO (10.15 kg ha-1 day-1; DOY 220) and WP (1.89 kg m-3; DOY 204) were obtained in winter, and highest values of ETa (2.05 mm day-1; DOY 364) and BIO (71.64 kg ha-1 day-1; DOY 364) in the summer and WP (3.88 kg m-3; DOY 92) in the autumn. The water productivity components can subsidize the monitoring of the agro-ecosystems, being a useful tool to quantify the annual variability of ETa and BIO.

Total and water-soluble phosphorus in broiler litter over three flocks with alum litter treatment and dietary inclusion of high available phosphorus corn and phytase supplementation.

PubMed

Miles, D M; Moore, P A; Smith, D R; Rice, D W; Stilborn, H L; Rowe, D R; Lott, B D; Branton, S L; Simmons, J D

2003-10-01

Three pen trials were conducted to determine the main effect of alum addition to litter on form of poultry litter P using a 2 x 2 factorial structure of the subunit treatments: diets including high available phosphorus/low phytate corn (HAPC) and phytase (PHYT). Male broilers (1,760 per flock) were grown to 42 d having starter diets with 0.45% available P and grower diets with 0.35% available P. In the first trial, total litter P (tP) was greatest for the yellow dent corn (YDC) diet (12 g/kg) and least for the HAPC and PHYT combination (H&P) diet (6.9 g/kg) with the individual PHYT and HAPC diets falling in between at 9.1 g/kg and 9.4 g/kg tP. Also in the first trial, the litter water-soluble P (wP) was highest for PHYT (2.8 g/kg), least for the HAPC and H&P diets (1.5 g/kg) with the YDC diet falling between (2.2 g/kg). Alum was added to the litter after the first experiment. In the second and third experiments, alum inclusion significantly reduced the wP when compared with the treatments with no alum. In the third trial, the least wP was present in the alum-HAPC treatment. Phytase, YDC, and HAPC diets with no alum litter treatment generated the most wP. Since these diets appear to have little or no difference with respect to quantity of wP, this work suggests that form of litter P generated by alternative diets should be considered as criteria when attempting to reduce P in broiler litter applied to land.

Post-Planck constraints on interacting vacuum energy

NASA Astrophysics Data System (ADS)

Wang, Yuting; Wands, David; Zhao, Gong-Bo; Xu, Lixin

2014-07-01

We present improved constraints on an interacting vacuum model using updated astronomical observations including the first data release from Planck. We consider a model with one dimensionless parameter, α, describing the interaction between dark matter and vacuum energy (with fixed equation of state w=-1). The background dynamics correspond to a generalized Chaplygin gas cosmology, but the perturbations have a zero sound speed. The tension between the value of the Hubble constant, H0, determined by Planck data plus WMAP polarization (Planck +WP) and that determined by the Hubble Space Telescope (HST) can be alleviated by energy transfer from dark matter to vacuum (α>0). A positive α increases the allowed values of H0 due to parameter degeneracy within the model using only cosmic microwave background data. Combining with additional data sets of including supernova type Ia (SN Ia) and baryon acoustic oscillation (BAO), we can significantly tighten the bounds on α. Redshift-space distortions (RSD), which constrain the linear growth of structure, provide the tightest constraints on vacuum interaction when combined with Planck+WP, and prefer energy transfer from vacuum to dark matter (α<0) which suppresses the growth of structure. Using the combined data sets of Planck +WP+Union2.1+BAO+RSD, we obtain the constraint on α to be -0.083<α<-0.006 (95% C.L.), allowing low H0 consistent with the measurement from 6dF Galaxy survey. This interacting vacuum model can alleviate the tension between RSD and Planck +WP in the ΛCDM model for α <0, or between HST measurements of H0 and Planck+WP for α>0, but not both at the same time.

Streptosporangium jiaoheense sp. nov. and Streptosporangium taraxaci sp. nov., actinobacteria isolated from soil and dandelion root (Taraxacum mongolicum Hand.-Mazz.).

PubMed

Zhao, Junwei; Guo, Lifeng; Li, Zhilei; Piao, Chenyu; Li, Yao; Li, Jiansong; Liu, Chongxi; Wang, Xiangjing; Xiang, Wensheng

2016-06-01

Two novel actinobacteria, designated strains NEAU-Jh1-4T and NEAU-Wp2-0T, were isolated from muddy soil collected from a riverbank in Jiaohe and a dandelion root collected from Harbin, respectively. A polyphasic study was carried out to establish the taxonomic positions of these two strains. The phylogenetic analysis based on the 16S rRNA gene sequences of strains NEAU-Jh1-4T and NEAU-Wp2-0T indicated that strain NEAU-Jh1-4T clustered with Streptosporangium nanhuense NEAU-NH11T (99.32 % 16S rRNA gene sequence similarity), Streptosporangium purpuratum CY-15110T (98.30 %) and Streptosporangium yunnanense CY-11007T (97.95 %) and strain NEAU-Wp2-0T clustered with 'Streptosporangium sonchi  ' NEAU-QS7 (99.39 %), 'Streptosporangium kronopolitis' NEAU-ML10 (99.26 %), 'Streptosporangium shengliense' NEAU-GH7 (98.85 %) and Streptosporangium longisporum DSM 43180T (98.69 %). Moreover, morphological and chemotaxonomic properties of the two isolates also confirmed their affiliation to the genus Streptosporangium. However, the low level of DNA-DNA hybridization and some phenotypic characteristics allowed the isolates to be differentiated from the most closely related species. Therefore, it is proposed that strains NEAU-Jh1-4T and NEAU-Wp2-0T represent two novel species of the genus Streptosporangium, for which the name Streptosporangium jiaoheense sp. nov. and Streptosporangium taraxaci sp. nov. are proposed. The type strains are NEAU-Jh1-4T (=CGMCC 4.7213T=JCM 30348T) and NEAU-Wp2-0T (=CGMCC 4.7217T=JCM 30349T), respectively.

VIEW OF SOUTH GUN EMPLACEMENT. NOTE THE EXCAVATED EDGE OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF SOUTH GUN EMPLACEMENT. NOTE THE EXCAVATED EDGE OF THE GUN BLOCK IN THE FOREGROUND. VIEW FACING NORTH - U.S. Naval Base, Pearl Harbor, Ford Island 5-Inch Antiaircraft Battery, South Gun Emplacement, Ford Island, Pearl City, Honolulu County, HI

Where do we go from here? Interim analysis to forge ahead in violence prevention.

PubMed

Dicker, Rochelle A; Jaeger, Sebastian; Knudson, Mary M; Mackersie, Robert C; Morabito, Diane J; Antezana, Javier; Texada, Michael

2009-12-01

The severity and disparity of interpersonal violent injury is staggering. Fifty-three per 100,000 African Americans (AA) die of homicide yearly, 20 per 100,000 in Latinos, whereas the rate is 3 per 100,000 in Caucasians. With the ultimate goal of reducing injury recidivism, which now stands at 35% to 50%, we have designed and implemented a hospital-based, case-managed violence prevention program uniquely applicable to trauma centers. The Wraparound Project (WP) seizes the "teachable moment" after injury to implement culturally competent case management (CM) and shepherd clients through risk reduction resources with city and community partners. The purpose of this study was to perform a detailed intermediate evaluation of this multi-modal violence prevention program. We hypothesized that this evaluation would demonstrate feasibility and early programmatic efficacy. We looked to identify areas of programmatic weakness that, if corrected, could strengthen the project and enhance its effectiveness. We performed intermediate evaluation on the 18-month-old program. We selected the Centers for Disease Control and Prevention-recommended instrument used for unintentional injury prevention programs and applied it to the WP. The four sequential stages in this methodology are formative, process, impact, and outcome. To test feasibility of WP, we used process evaluation. To evaluate intermediate goals of risk reduction and early efficacy, we used impact evaluation. Four hundred thirty-five people met screening criteria. The two case managers were able to make contact and screen 73% of gun shot victims, and 57% of stab wound victims. Of those not seen, 48% were in the hospital for 6 h/wk with the client. Forty-one percent of the time, they spent 3 hours to 6 hours. Seventeen of 18 people who required >6 hours had two to three needs. Attrition rate is only 4%. The table demonstrates percent success thus far in providing risk reduction resources. WP case managers served high-risk clients by developing trust, credibility, and a risk reduction plan. Cultural competency has been vital. Six of seven major needs were successfully addressed at least 50% of the time. The value of reporting these results has led WP to gain credibility with municipal stakeholders, who have now agreed to fund a third CM position. Intermediate evaluation provided a framework in our effort to achieve the ultimate goal of reducing recidivism through culturally competent CM and risk factor modification.

CONCEPTUAL DESIGN OF A LUNAR REGOLITH CLUSTERED-REACTOR SYSTEM

DOE Office of Scientific and Technical Information (OSTI.GOV)

John Darrell Bess

2009-06-01

It is proposed that a fast-fission, heatpipe-cooled, lunar-surface power reactor system be divided into subcritical units that could be launched safely without the incorporation of additional spectral shift absorbers or other complex means of control. The reactor subunits are to be emplaced directly into the lunar regolith utilizing the regolith not just for shielding but as the reflector material to increase the neutron economy of the system. While a single subunit cannot achieve criticality by itself, coordinated placement of additional subunits will provide a critical reactor system for lunar surface power generation. A lunar regolith clustered-reactor system promotes reliability, safety,more » and ease of manufacture and testing at the cost of a slight increase in launch mass per rated power level and an overall reduction in neutron economy when compared to a single-reactor system. Additional subunits may be launched with future missions to increase the cluster size and power according to desired lunar base power demand and lifetime. The results address the potential uncertainties associated with the lunar regolith material and emplacement of the subunit systems. Physical distance between subunits within the clustered emplacement exhibits the most significant feedback regarding changes in overall system reactivity. Narrow, deep holes will be the most effective in reducing axial neutron leakage from the core. The variation in iron concentration in the lunar regolith can directly influence the overall system reactivity although its effects are less than the more dominant factors of subunit emplacement.« less

Identification of the Fungal Pathogen that Causes Strawberry Anthracnose in Bangladesh and Evaluation of In Vitro Fungicide Activity

PubMed Central

Akhter, Md. Shamim; Alam, Shahidul; Islam, Md. Shafiqul

2009-01-01

This study was conducted to identify the Colletotrichum species causing anthracnose disease of strawberry in Balgladesh and to evaluate in vitro activity of commercial fungicides it. Based on morphological and cultural characteristics, all 22 isolates were identified as Colletotrichum gloeosporioides. They developed white or glittery colonies with grey to dark grey reverse colony colors and they produced cylindrical conidia. The efficacy of five commercial fungicides, Bavistin DF, Dithane M-45, Sulcox 50 WP, Corzim 50 WP and Rovral 50 WP, were tested against the fungus. Bavistin inhibited radial growth completely and was followed in efficacy by Dithane M-45. In Bavistin DF treated media, the fungus did not produce conidia. The percent inhibition of radial growth of the fungus was increased with the increasing concentrations of fungicide. PMID:23983513

Systemic Approach of a Virtual Enterprise that Constructs Wireless Payment Mechanisms

NASA Astrophysics Data System (ADS)

Assimakopoulos, Nikitas A.; Riggas, Anastasis N.; Kotsimpos, George K.

2004-08-01

Enterprises and Organizations are realizing that there are many win-win scenarios, for their customers and business partners, using the latest technology to enact convenient and secure purchases `over the air'. Wireless Payment (W/P) is the key element of Wireless Commerce. Businesses around the world are attempting to position themselves to operate in a highly competitive global economy. A single organization is often not able to develop sufficient internal design or production capabilities to respond effectively within a short period of time. The focus of this paper will be on the development and analysis of a Virtual Enterprise Architecture for the construction of W/P Mechanisms using Systemic Methodologies. A framework for the rapid and efficient integration of the business processes of the participating companies that construct W/P Mechanisms is provided.

Pipeline active filter utilizing a booth type multiplier

NASA Technical Reports Server (NTRS)

Nathan, Robert (Inventor)

1987-01-01

Multiplier units of the modified Booth decoder and carry-save adder/full adder combination are used to implement a pipeline active filter wherein pixel data is processed sequentially, and each pixel need only be accessed once and multiplied by a predetermined number of weights simultaneously, one multiplier unit for each weight. Each multiplier unit uses only one row of carry-save adders, and the results are shifted to less significant multiplier positions and one row of full adders to add the carry to the sum in order to provide the correct binary number for the product Wp. The full adder is also used to add this product Wp to the sum of products .SIGMA.Wp from preceding multiply units. If m.times.m multiplier units are pipelined, the system would be capable of processing a kernel array of m.times.m weighting factors.

Preharvest quarantine treatments of chlorantraniliprole, clothianidin, and imidacloprid-based insecticides for control of Japanese beetle (Coleoptera: Scarabaeidae) and other scarab larvae in the root zone of field-grown nursery trees.

PubMed

Oliver, Jason B; Ranger, Christopher M; Reding, Michael E; Moyseenko, James J; Youssef, Nadeer N; Bray, Alicia M

2013-06-01

Japanese beetle, Popillia japonica Newman (Coleoptera: Scarabaeidae), is an important quarantine pest of nurseries. Nursery plant movement from P. japonica-infested regions is regulated by the U.S. Domestic Japanese Beetle Harmonization Plan (DJHP), which classifies states by risk categories. Treatments for category 2 states include preharvest soil surface treatment of nursery plants grown in field soil using Discus SC, Marathon (1G or 60 WP), or Flagship (0.22G or 25 WG). In this study, Discus, Marathon 60 WP, or Flagship 0.22G DJHP standards were compared with labeled rates of non-DJHP-approved insecticides, including neonicotinoids clothianidin (Arena 50WDG), generic imidacloprid (Quali-Pro Imidacloprid 2 F T&O Insecticide, Mallet 2 F T&O Insecticide, and Lada 2 F Insecticide), and imidacloprid + bifenthrin (Allectus SC), as well as the anthranilic diamide, chlorantraniliprole (Acelepryn Insecticide). Arena provided 100% P. japonica control in May, June, and July over four test years, but had one larva recovered during August in two of those 4 yr. Acelepryn did not provide DJHP-acceptable P. japonica control. During July, Allectus provided 100% P. japonica control in three of four test years, but had four larvae in one test year. Other treatments tested only during July, which provided 100% P. japonica control, included Discus (five tests); Marathon, Quali-Pro, and Mallet (two tests); and Lada and Flagship (one test). Generic imidacloprid 2 F formulations were equivalent in P. japonica control to DJHP-approved insecticides. Insecticides generally performed poorly on other scarabs or curculionid larvae. The study supports Arena, Allectus, and generic imidacloprid 2 F products as suitable candidates for the DJHP.

System-Level Logistics for Dual Purpose Canister Disposal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalinina, Elena A.

2014-06-03

The analysis presented in this report investigated how the direct disposal of dual purpose canisters (DPCs) may be affected by the use of standard transportation aging and disposal canisters (STADs), early or late start of the repository, and the repository emplacement thermal power limits. The impacts were evaluated with regard to the availability of the DPCs for emplacement, achievable repository acceptance rates, additional storage required at an interim storage facility (ISF) and additional emplacement time compared to the corresponding repackaging scenarios, and fuel age at emplacement. The result of this analysis demonstrated that the biggest difference in the availability ofmore » UNF for emplacement between the DPC-only loading scenario and the DPCs and STADs loading scenario is for a repository start date of 2036 with a 6 kW thermal power limit. The differences are also seen in the availability of UNF for emplacement between the DPC-only loading scenario and the DPCs and STADs loading scenario for the alternative with a 6 kW thermal limit and a 2048 start date, and for the alternatives with a 10 kW thermal limit and 2036 and 2048 start dates. The alternatives with disposal of UNF in both DPCs and STADs did not require additional storage, regardless of the repository acceptance rate, as compared to the reference repackaging case. In comparison to the reference repackaging case, alternatives with the 18 kW emplacement thermal limit required little to no additional emplacement time, regardless of the repository start time, the fuel loading scenario, or the repository acceptance rate. Alternatives with the 10 kW emplacement thermal limit and the DPCs and STADs fuel loading scenario required some additional emplacement time. The most significant decrease in additional emplacement time occurred in the alternative with the 6 kW thermal limit and the 2036 repository starting date. The average fuel age at emplacement ranges from 46 to 88 years. The maximum fuel age at emplacement ranges from 81 to 146 years. The difference in the average and maximum age of fuel at emplacement between the DPC-only and the DPCs and STADs fuel loading scenarios becomes less significant as the repository thermal limit increases and as the repository start date increases. In general, the role of STADs is to store young (30 year or younger) high burnup (45 GWD/MTU or higher) fuel. Recommendations for future study include detailed evaluation of the feasible alternatives with regard to the costs and factors not considered in this analysis, such as worker dose, dose to members of the public, and economic benefits to host entities. It is also recommended to conduct an additional analysis to evaluate the assumption regarding the transportability and disposability of DPCs for the next iteration of the direct disposal of DPCs study.« less

Buffered and unbuffered dike emplacement on Earth and Venus - Implications for magma reservoir size, depth, and rate of magma replenishment

NASA Technical Reports Server (NTRS)

Parfitt, E. A.; Head, J. W., III

1993-01-01

Models of the emplacement of lateral dikes from magma chambers under constant (buffered) driving pressure conditions and declining (unbuffered) driving pressure conditions indicate that the two pressure scenarios lead to distinctly different styles of dike emplacement. In the unbuffered case, the lengths and widths of laterally emplaced dikes will be severely limited and the dike lengths will be highly dependent on chamber size; this dependence suggests that average dike length can be used to infer the dimensions of the source magma reservoir. On Earth, the characteristics of many mafic-dike swarms suggest that they were emplaced in buffered conditions (e.g., the Mackenzie dike swarm in Canada and some dikes within the Scottish Tertiary). On Venus, the distinctive radial fractures and graben surrounding circular to oval features and edifices on many size scales and extending for hundreds to over a thousand km are candidates for dike emplacement in buffered conditions.

Characterization of Chemosynthetic Microbial Mats Associated with Intertidal Hydrothermal Sulfur Vents in White Point, San Pedro, CA, USA

PubMed Central

Miranda, Priscilla J.; McLain, Nathan K.; Hatzenpichler, Roland; Orphan, Victoria J.; Dillon, Jesse G.

2016-01-01

The shallow-sea hydrothermal vents at White Point (WP) in Palos Verdes on the southern California coast support microbial mats and provide easily accessed settings in which to study chemolithoautotrophic sulfur cycling. Previous studies have cultured sulfur-oxidizing bacteria from the WP mats; however, almost nothing is known about the in situ diversity and activity of the microorganisms in these habitats. We studied the diversity, micron-scale spatial associations and metabolic activity of the mat community via sequence analysis of 16S rRNA and aprA genes, fluorescence in situ hybridization (FISH) microscopy and sulfate reduction rate (SRR) measurements. Sequence analysis revealed a diverse group of bacteria, dominated by sulfur cycling gamma-, epsilon-, and deltaproteobacterial lineages such as Marithrix, Sulfurovum, and Desulfuromusa. FISH microscopy suggests a close physical association between sulfur-oxidizing and sulfur-reducing genotypes, while radiotracer studies showed low, but detectable, SRR. Comparative 16S rRNA gene sequence analyses indicate the WP sulfur vent microbial mat community is similar, but distinct from other hydrothermal vent communities representing a range of biotopes and lithologic settings. These findings suggest a complete biological sulfur cycle is operating in the WP mat ecosystem mediated by diverse bacterial lineages, with some similarity with deep-sea hydrothermal vent communities. PMID:27512390

A milk-based wolfberry preparation prevents prenatal stress-induced cognitive impairment of offspring rats, and inhibits oxidative damage and mitochondrial dysfunction in vitro.

PubMed

Feng, Zhihui; Jia, Haiqun; Li, Xuesen; Bai, Zhuanli; Liu, Zhongbo; Sun, Lijuan; Zhu, Zhongliang; Bucheli, Peter; Ballèvre, Olivier; Wang, Junkuan; Liu, Jiankang

2010-05-01

Lycium barbarum (Fructus Lycii, Wolfberry, or Gouqi) belongs to the Solanaceae. The red-colored fruits of L. barbarum have been used for a long time as an ingredient in Chinese cuisine and brewing, and also in traditional Chinese herbal medicine for improving health. However, its effects on cognitive function have not been well studied. In the present study, prevention of a milk-based wolfberry preparation (WP) on cognitive dysfunction was tested in a prenatal stress model with rats and the antioxidant mechanism was tested by in vitro experiments. We found that prenatal stress caused a significant decrease in cognitive function (Morris water maze test) in female offspring. Pretreatment of the mother rats with WP significantly prevented the prenatal stress-induced cognitive dysfunction. In vitro studies showed that WP dose-dependently scavenged hydroxyl and superoxide radicals (determined by an electron spin resonance spectrometric assay), and inhibited FeCl(2)/ascorbic acid-induced dysfunction in brain tissue and tissue mitochondria, including increases in reactive oxygen species and lipid peroxidation and decreases in the activities of complex I, complex II, and glutamate cysteine ligase. These results suggest that dietary supplementation with WP may be an effective strategy for preventing the brain oxidative mitochondrial damage and cognitive dysfunction associated with prenatal stress.

Thermocouple psychrometer measurements of in situ water potential changes in heated welded tuff

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mao, Nai-hsien; Wang, H.F.

1991-10-01

Ten thermocouple psychrometers (TCPs) to measure water potential (WP) were installed in three holes in G-Tunnel at the Nevada Test Site as part of the Prototype Engineered Barrier System Field Tests. We calibrated the TCPs in NaCl solutions up to 80{degrees}C (176{degrees}F) in the laboratory. In two holes, we used rubber sleeves and packers to house TCPs, and in the third hole, we used foam. All three holes were grouted behind the TCP assemblages. The initial moisture condition indicated by TCP data was about 99.5% relative humidity or a WP of about {minus}5 bar. This corresponded to 15.4 g/m{sup 3}more » of water in the air near the borehole wall, which was much wetter than we expected. A drying and re-wetting cycle peaked at about day 140 with a WP of {minus}65 bar in borehole P3, located below the heater. A similar cycle but reduced in scale was found at about day 175 with a WP of {minus}45 bar in borehole P2, above the heater. This difference is drying behavior above and below the heater was also observed from neutron data and was explained as a gravity effect.« less

VIEW OF EAST GUN EMPLACEMENT. NOTE THE STEEL REINFORCING RODS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF EAST GUN EMPLACEMENT. NOTE THE STEEL REINFORCING RODS PROTRUDING FROM THE BROKEN TOP OF THE RETAINING WALL. VIEW FACING NORTHEAST - U.S. Naval Base, Pearl Harbor, Ford Island 5-Inch Antiaircraft Battery, East Gun Emplacement, Ford Island, Pearl City, Honolulu County, HI

Degradation of Energetic Compounds using Zero-Valent Iron (ZVI)

DTIC Science & Technology

2012-03-01

control number. 1. REPORT DATE MAR 2012 2. REPORT TYPE 3. DATES COVERED 00-00-2012 to 00-00-2012 4 . TITLE AND SUBTITLE Degradation of Energetic...the column effluents were collected and passed through a 0.22- µm cellulose membrane filter (Millipore, Bedford, MA) for HPLC analysis. Degradation ...FINAL REPORT Degradation of Energetic Compounds Using Zero-Valent Iron (ZVI) ESTCP Project WP-200524 MARCH 2012 Byung J. Kim U.S

Density Functional Theory Study of Chemical Sensing on Surfaces of Single-Layer MOS2 and Graphene (Postprint)

DTIC Science & Technology

2014-04-22

Ruth Pachter AFRL/RXA APRIL 2014 Interim Report Distribution A . Approved for public release; distribution unlimited. See...subject to any penalty for failing to comply with a collection of information if it dows not display a currently valid OMB control number. PLEASE DO NOT...SPONSOR/MONITOR’S REPORT NUMBER(S) AFRL-RX-WP-JA-2014-0158 12. DISTRIBUTION / AVAILABILITY STATEMENT Distribution A . Approved for public release

White grape pomace extracts, obtained by a sequential enzymatic plus ethanol-based extraction, exert antioxidant, anti-tyrosinase and anti-inflammatory activities.

PubMed

Ferri, Maura; Rondini, Greta; Calabretta, Maria Maddalena; Michelini, Elisa; Vallini, Veronica; Fava, Fabio; Roda, Aldo; Minnucci, Giordano; Tassoni, Annalisa

2017-10-25

The present work aimed at optimizing a two-step enzymatic plus solvent-based process for the recovery of bioactive compounds from white grape (Vitis vinifera L., mix of Trebbiano and Verdicchio cultivars) pomace, the winemaking primary by-product. Phenolic compounds solubilised by water enzyme-assisted and ethanol-based extractions of wet (WP) and dried (DP) pomace were characterised for composition and tested for antioxidant, anti-tyrosinase and anti-inflammatory bioactivities. Ethanol treatment led to higher phenol yields than water extraction, while DP samples showed the highest capacity of releasing polyphenols, most probably as a positive consequence of the pomace drying process. Different compositions and bioactivities were observed between water and ethanol extracts and among different treatments and for the first time the anti-tyrosinase activity of V. vinifera pomace extracts, was here reported. Enzymatic treatments did not significantly improve the total amount of solubilised compounds; Celluclast in DP led to the recovery of extracts enriched in specific compounds, when compared to control. The best extracts (enzymatic plus ethanol treatment total levels) were obtained from DP showing significantly higher amounts of polyphenols, flavonoids, flavanols and tannins and exerted higher antioxidant and anti-tyrosinase activities than WP total extracts. Conversely, anti-inflammatory capacity was only detected in water (with and without enzyme) extracts, with WP samples showing on average a higher activity than DP. The present findings demonstrate that white grape pomace constitute a sustainable source for the extraction of phytochemicals that might be exploited as functional ingredients in the food, nutraceutical, pharmaceutical or cosmetic industries. Copyright © 2017 Elsevier B.V. All rights reserved.

Sensitivity of tropical forest aboveground productivity to climate anomalies in SW Costa Rica

NASA Astrophysics Data System (ADS)

Hofhansl, Florian; Kobler, Johannes; Ofner, Joachim; Drage, Sigrid; Pölz, Eva-Maria; Wanek, Wolfgang

2014-12-01

The productivity of tropical forests is driven by climate (precipitation, temperature, and light) and soil fertility (geology and topography). While large-scale drivers of tropical productivity are well established, knowledge on the sensitivity of tropical lowland net primary production to climate anomalies remains scarce. We here analyze seven consecutive years of monthly recorded tropical forest aboveground net primary production (ANPP) in response to a recent El Niño-Southern Oscillation (ENSO) anomaly. The ENSO transition period resulted in increased temperatures and decreased precipitation during the El Niño dry period, causing a decrease in ANPP. However, the subsequent La Niña wet period caused strong increases in ANPP such that drought-induced reductions were overcompensated. Most strikingly, the climatic controls differed between canopy production (CP) and wood production (WP). Whereas CP showed strong seasonal variation but was not affected by ENSO, WP decreased significantly in response to a 3°C increase in annual maximum temperatures during the El Niño period but subsequently recovered to above predrought levels during the La Niña period. Moreover, the climate sensitivity of tropical forest ANPP components was affected by local topography (water availability) and disturbance history (species composition). Our results suggest that projected increases in temperature and dry season length could impact tropical carbon sequestration by shifting ANPP partitioning toward decreased WP, thus decreasing the carbon storage of highly productive lowland forests. We conclude that the impact of climate anomalies on tropical forest productivity is strongly related to local site characteristics and will therefore likely prevent uniform responses of tropical lowland forests to projected global changes.

Vertical jump biomechanics after plyometric, weight lifting, and combined (weight lifting + plyometric) training.

PubMed

Arabatzi, Fotini; Kellis, Eleftherios; Saèz-Saez De Villarreal, Eduardo

2010-09-01

The purpose of this study was to compare the effects of an Olympic weight lifting (OL), a plyometric (PL), and combined weight lifting + plyometric (WP) training program on vertical jump (VJ) biomechanics. Thirty-six men were assigned randomly to 4 groups: PL group (n = 9), OL group (n = 9), WP group (), and control (C) group (n = 8). The experimental groups trained 3 d.wk, for 8 weeks. Sagital kinematics, VJ height, power, and electromyographic (EMG) activity from rectus femoris (RF) and medial gastrocnemius (GAS) were collected during squat jumping and countermovement jumping (CMJ) before and after training. The results showed that all experimental groups improved VJ height (p < 0.05). The OL training improved power and muscle activation during the concentric phase of the CMJ while the subjects used a technique with wider hip and knee angles after training (p < 0.05). The PL group subjects did not change their CMJ technique although there was an increase in RF activation and a decrease of GAS activity after training (p < 0.05). The WP group displayed a decline in maximal hip angle and a lower activation during the CMJ after training (p < 0.05). These results indicate that all training programs are adequate for improving VJ performance. However, the mechanisms for these improvements differ between the 3 training protocols. Olympic weight lifting training might be more appropriate to achieve changes in VJ performance and power in the precompetition period of the training season. Emphasis on the PL exercises should be given when the competition period approaches, whereas the combination of OL and PL exercises may be used in the transition phases from precompetition to the competition period.

The Transcriptional Response of Listeria monocytogenes during Adaptation to Growth on Lactate and Diacetate Includes Synergistic Changes That Increase Fermentative Acetoin Production▿†

PubMed Central

Stasiewicz, Matthew J.; Wiedmann, Martin; Bergholz, Teresa M.

2011-01-01

The organic acids lactate and diacetate are commonly used in combination in ready-to-eat foods because they show synergistic ability to inhibit the growth of Listeria monocytogenes. Full-genome microarrays were used to investigate the synergistic transcriptomic responses of two L. monocytogenes strains, H7858 (serotype 4b) and F6854 (serotype 1/2a), to these two organic acids under conditions representing osmotic and cold stress encountered in foods. Strains were exposed to brain heart infusion (BHI) broth at 7°C with 4.65% water-phase (w.p.) NaCl at pH 6.1 with (i) 2% w.p. potassium lactate, (ii) 0.14% w.p. sodium diacetate, (iii) the combination of both at the same levels, or (iv) no organic acids as a control. RNA was extracted 8 h after exposure, during lag phase, to capture gene transcription changes during adaptation to the organic acid stress. Significant differential transcription of 1,041 genes in H7858 and 640 genes in F6854 was observed in at least one pair of the 4 different treatments. The effects of combined treatment with lactate and diacetate included (i) synergistic transcription differences for 474 and 209 genes in H7858 and F6854, respectively, (ii) differential transcription of genes encoding cation transporters and ABC transporters of metals, and (iii) altered metabolism, including induction of a nutrient-limiting stress response, reduction of menaquinone biosynthesis, and a shift from fermentative production of acetate and lactate to energetically less favorable, neutral acetoin. These data suggest that additional treatments that interfere with cellular energy generation processes could more efficiently inhibit the growth of L. monocytogenes. PMID:21666015

Postactivation potentiation of sprint acceleration performance using plyometric exercise.

PubMed

Turner, Anthony P; Bellhouse, Sam; Kilduff, Liam P; Russell, Mark

2015-02-01

Postactivation potentiation (PAP), an acute and temporary enhancement of muscular performance resulting from previous muscular contraction, commonly occurs after heavy resistance exercise. However, this method of inducing PAP has limited application to the precompetition practices (e.g., warm-up) of many athletes. Very few studies have examined the influence of plyometric activity on subsequent performance; therefore, we aimed to examine the influence of alternate-leg bounding on sprint acceleration performance. In a randomized crossover manner, plyometric-trained men (n = 23) performed seven 20-m sprints (with 10-m splits) at baseline, ∼15 seconds, 2, 4, 8, 12, and 16 minutes after a walking control (C) or 3 sets of 10 repetitions of alternate-leg bounding using body mass (plyometric, P) and body mass plus 10% (weighted plyometric, WP). Mean sprint velocities over 10 and 20 m were similar between trials at baseline. At ∼15 seconds, WP impaired 20-m sprint velocity by 1.4 ± 2.5% when compared with C (p = 0.039). Thereafter, 10- and 20-m sprint velocities improved in WP at 4 minutes (10 m: 2.2 ± 3.1%, p = 0.009; 20 m: 2.3 ± 2.6%, p = 0.001) and 8 minutes (10 m: 2.9 ± 3.6%, p = 0.002; 20 m: 2.6 ± 2.8%, p = 0.001) compared with C. Improved 10-m sprint acceleration performance occurred in P at 4 minutes (1.8 ± 3.3%, p = 0.047) relative to C. Therefore, sprint acceleration performance is enhanced after plyometric exercise providing adequate recovery is given between these activities; however, the effects may differ according to whether additional load is applied. This finding presents a practical method to enhance the precompetition practices of athletes.

The Relationship of Disordered Eating Attitudes With Body Composition and Anthropometric Indices in Physical Education Students.

PubMed

Rouzitalab, Tohid; Pourghassem Gargari, Bahram; Amirsasan, Ramin; Asghari Jafarabadi, Mohammad; Farsad Naeimi, Alireza; Sanoobar, Meisam

2015-11-01

Abnormal eating behavior, unhealthy weight control methods, and eating disordered symptoms have risen among college students. The aim of this study was to examine disordered eating attitudes and their relationship with anthropometric and body composition indices in physical education students in Tabriz, the capital of East Azerbaijan province, Iran. This cross-sectional study was conducted on 210 physical education students, 105 males and 105 females aged 18 to 25, who were selected by systematic random sampling from physical education faculty of Tabriz University in Tabriz, Iran, in 2013. Eating attitude test (EAT-26) was used for the assessment of disordered eating attitudes. In addition, anthropometric and body composition indices were assessed. About 10% of the studied subject had disturbed eating attitudes; significantly more males (15.4%) reported an EAT-26 ≥ 20 (disordered eating attitudes) than females (4.8%) (P < 0.05). In males, the EAT-26 score was positively correlated with weist perimeter (WP) (r = 0.21, P < 0.05) and the waist-to-hip ratio (r = 0.26, P < 0.01). In females, the EAT-26 score was positively correlated with weight (r = 0.19, P < 0.05) and the WP (r = 0.28, P < 0.01). In females, weight (P < 0.05), body mass index (BMI) (P < 0.05), WP (P < 0.01), and waist-to-hip ratio (P < 0.05) were significantly different between disordered eating attitude and healthy subjects, while in males there was no significant difference between the two groups regarding the anthropometric and body composition indices. Abnormal eating attitude was notable among physical education students in Tabriz, Iran. It seems that some anthropometric indices such as BMI and central obesity indices were related to the increase of disordered eating attitude.

Text Comprehension and Oral Language as Predictors of Word-Problem Solving: Insights into Word-Problem Solving as a Form of Text Comprehension

ERIC Educational Resources Information Center

Fuchs, Lynn S.; Gilbert, Jennifer K.; Fuchs, Douglas; Seethaler, Pamela M.; N. Martin, BrittanyLee

2018-01-01

This study was designed to deepen insights on whether word-problem (WP) solving is a form of text comprehension (TC) and on the role of language in WPs. A sample of 325 second graders, representing high, average, and low reading and math performance, was assessed on (a) start-of-year TC, WP skill, language, nonlinguistic reasoning, working memory,…

Lack of Cross-protection against Bordetella holmesii after Pertussis Vaccination

PubMed Central

Zhang, Xuqing; Weyrich, Laura S.; Lavine, Jennie S.; Karanikas, Alexia T.

2012-01-01

Bordetella holmesii, a species closely related to B. pertussis, has been reported sporadically as a cause of whooping cough–like symptoms. To investigate whether B. pertussis–induced immunity is protective against infection with B. holmesii, we conducted an analysis using 11 human respiratory B. holmesii isolates collected during 2005–2009 from a highly B. pertussis–vaccinated population in Massachusetts. Neither whole-cell (wP) nor acellular (aP) B. pertussis vaccination conferred protection against these B. holmesii isolates in mice. Although T-cell responses induced by wP or aP cross-reacted with B. holmesii, vaccine-induced antibodies failed to efficiently bind B. holmesii. B. holmesii–specific antibodies provided in addition to wP were sufficient to rapidly reduce B. holmesii numbers in mouse lungs. Our findings suggest the established presence of B. holmesii in Massachusetts and that failure to induce cross-reactive antibodies may explain poor vaccine-induced cross-protection. PMID:23092514

Large magnetoresistance in the type-II Weyl semimetal WP 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Aifeng; Graf, D.; Liu, Yu

In this paper, we report a magnetotransport study on type-II Weyl semimetal WP 2 single crystals. Magnetoresistance exhibits a nonsaturating H n field dependence (14 300% at 2 K and 9 T), whereas systematic violation of Kohler's rule was observed. Quantum oscillations reveal a complex multiband electronic structure. The cyclotron effective mass close to the mass of free electron m e was observed in quantum oscillations along the b axis, while a reduced effective mass of about 0.5 m e was observed in α-axis quantum oscillations, suggesting Fermi surface anisotropy. The temperature dependence of the resistivity shows a large upturnmore » that cannot be explained by the multiband magnetoresistance of conventional metals. Finally, even though the crystal structure of WP 2 is not layered as in transition-metal dichalcogenides, quantum oscillations suggest partial two-dimensional character.« less

Large magnetoresistance in the type-II Weyl semimetal WP 2

DOE PAGES

Wang, Aifeng; Graf, D.; Liu, Yu; ...

2017-09-11

In this paper, we report a magnetotransport study on type-II Weyl semimetal WP 2 single crystals. Magnetoresistance exhibits a nonsaturating H n field dependence (14 300% at 2 K and 9 T), whereas systematic violation of Kohler's rule was observed. Quantum oscillations reveal a complex multiband electronic structure. The cyclotron effective mass close to the mass of free electron m e was observed in quantum oscillations along the b axis, while a reduced effective mass of about 0.5 m e was observed in α-axis quantum oscillations, suggesting Fermi surface anisotropy. The temperature dependence of the resistivity shows a large upturnmore » that cannot be explained by the multiband magnetoresistance of conventional metals. Finally, even though the crystal structure of WP 2 is not layered as in transition-metal dichalcogenides, quantum oscillations suggest partial two-dimensional character.« less

Lack of pregnancy warnings on over-the-counter dermatologic products containing potentially harmful hydroquinone.

PubMed

Bio, L L; Cies, J J

2017-07-01

To determine the presence of pregnancy warnings on over-the-counter (OTC) dermatologic products with hydroquinone, a potentially harmful ingredient. Data were obtained from the Food and Drug Administration National Drug Code Directory and Label Repository to identify OTC dermatologic products containing hydroquinone. Products were stratified based on pregnancy or general warning presence (WP) or absence (WA). Product characteristics were compared between groups: hydroquinone concentration, presence of external packaging, indication and warning statements. Of the 112 products studied, 21 had a pregnancy warning and 3 included a general warning against use: WP (n=24) and WA (n=88) group. External packaging was more prevalent in the WP group compared to WA (62.5% vs 29.5%, P=0.004). Majority of OTC dermatologic products containing hydroquinone did not have a pregnancy warning. This highlights the need for improved labeling and informs providers caring for pregnant women of OTC labeling limitations.

Low temperature resistivity plateau and non-saturating magnetoresistance in Type-II Weyl semimetal WP2

NASA Astrophysics Data System (ADS)

Nagpal, V.; Kumar, P.; Sudesh, Patnaik, S.

2018-04-01

We have studied the resistivity and magnetoresistance (MR) properties of the recently predicted type-II Weyl semimetal WP2. Polycrystalline WP2 is synthesized using solid state reaction and crystallizes in an orthorhombic structure with the Cmc21 spacegroup. The temperature dependent resistivity is enhanced with the application of magnetic field and a resistivity plateau is observed at low temperatures. We find a small dip in resistivity around 30K at 5T field suggesting that there might be a metal-insulator-like transition at higher magnetic fields. A non-saturating magnetoresistance is observed at low temperatures with maximum MR ˜ 94% at 2K and 6T. The value of MR decreases with the increase in temperature. We see a deviation from Kohler's power law which implies that the system comprises of two types of charge carriers.

The inverse Wiener polarity index problem for chemical trees.

PubMed

Du, Zhibin; Ali, Akbar

2018-01-01

The Wiener polarity number (which, nowadays, known as the Wiener polarity index and usually denoted by Wp) was devised by the chemist Harold Wiener, for predicting the boiling points of alkanes. The index Wp of chemical trees (chemical graphs representing alkanes) is defined as the number of unordered pairs of vertices (carbon atoms) at distance 3. The inverse problems based on some well-known topological indices have already been addressed in the literature. The solution of such inverse problems may be helpful in speeding up the discovery of lead compounds having the desired properties. This paper is devoted to solving a stronger version of the inverse problem based on Wiener polarity index for chemical trees. More precisely, it is proved that for every integer t ∈ {n - 3, n - 2,…,3n - 16, 3n - 15}, n ≥ 6, there exists an n-vertex chemical tree T such that Wp(T) = t.

Dramatically Promoted Swelling of a Hydrogel by Pillar[6]arene-Ferrocene Complexation with Multistimuli Responsiveness.

PubMed

Ni, Mengfei; Zhang, Ning; Xia, Wei; Wu, Xuan; Yao, Chenhao; Liu, Xin; Hu, Xiao-Yu; Lin, Chen; Wang, Leyong

2016-05-25

The swelling-shrinking transition of hydrogels is crucial for their wide applications such as actuators and drug delivery. We hereby fabricated a smart hydrogel with ferrocene groups on pendant of polymer networks. While it was immersed in the water-soluble pillar[6]arene (WP6) aqueous solution, the hydrogel was dramatically swollen, which was an approximately 11-fold promotion in weight compared with that in pure water, due to the formation of the inclusion complexes between WP6 and ferrocene groups in the hydrogel. In particular, the well-swollen hydrogel exhibited good responsiveness to multistimuli including temperature, pH, redox, and competitive guests by tuning the dissociation/formation of WP6-ferrocene inclusion complexes or the strength of their charges. Meanwhile, potential application of such a smart hydrogel in pH-responsive drug release was demonstrated as well.

A new physics-based modeling approach for tsunami-ionosphere coupling

NASA Astrophysics Data System (ADS)

Meng, X.; Komjathy, A.; Verkhoglyadova, O. P.; Yang, Y.-M.; Deng, Y.; Mannucci, A. J.

2015-06-01

Tsunamis can generate gravity waves propagating upward through the atmosphere, inducing total electron content (TEC) disturbances in the ionosphere. To capture this process, we have implemented tsunami-generated gravity waves into the Global Ionosphere-Thermosphere Model (GITM) to construct a three-dimensional physics-based model WP (Wave Perturbation)-GITM. WP-GITM takes tsunami wave properties, including the wave height, wave period, wavelength, and propagation direction, as inputs and time-dependently characterizes the responses of the upper atmosphere between 100 km and 600 km altitudes. We apply WP-GITM to simulate the ionosphere above the West Coast of the United States around the time when the tsunami associated with the March 2011 Tohuku-Oki earthquke arrived. The simulated TEC perturbations agree with Global Positioning System observations reasonably well. For the first time, a fully self-consistent and physics-based model has reproduced the GPS-observed traveling ionospheric signatures of an actual tsunami event.

Handling and Emplacement Options for Deep Borehole Disposal Conceptual Design.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cochran, John R.; Hardin, Ernest

2015-07-01

This report presents conceptual design information for a system to handle and emplace packages containing radioactive waste, in boreholes 16,400 ft deep or possibly deeper. Its intended use is for a design selection study that compares the costs and risks associated with two emplacement methods: drill-string and wireline emplacement. The deep borehole disposal (DBD) concept calls for siting a borehole (or array of boreholes) that penetrate crystalline basement rock to a depth below surface of about 16,400 ft (5 km). Waste packages would be emplaced in the lower 6,560 ft (2 km) of the borehole, with sealing of appropriate portionsmore » of the upper 9,840 ft (3 km). A deep borehole field test (DBFT) is planned to test and refine the DBD concept. The DBFT is a scientific and engineering experiment, conducted at full-scale, in-situ, without radioactive waste. Waste handling operations are conceptualized to begin with the onsite receipt of a purpose-built Type B shipping cask, that contains a waste package. Emplacement operations begin when the cask is upended over the borehole, locked to a receiving flange or collar. The scope of emplacement includes activities to lower waste packages to total depth, and to retrieve them back to the surface when necessary for any reason. This report describes three concepts for the handling and emplacement of the waste packages: 1) a concept proposed by Woodward-Clyde Consultants in 1983; 2) an updated version of the 1983 concept developed for the DBFT; and 3) a new concept in which individual waste packages would be lowered to depth using a wireline. The systems described here could be adapted to different waste forms, but for design of waste packaging, handling, and emplacement systems the reference waste forms are DOE-owned high- level waste including Cs/Sr capsules and bulk granular HLW from fuel processing. Handling and Emplacement Options for Deep Borehole Disposal Conceptual Design July 23, 2015 iv ACKNOWLEDGEMENTS This report has benefited greatly from review principally by Steve Pye, and also by Paul Eslinger, Dave Sevougian and Jiann Su.« less

Architecture and emplacement of flood basalt flow fields: case studies from the Columbia River Basalt Group, NW USA

NASA Astrophysics Data System (ADS)

Vye-Brown, C.; Self, S.; Barry, T. L.

2013-03-01

The physical features and morphologies of collections of lava bodies emplaced during single eruptions (known as flow fields) can be used to understand flood basalt emplacement mechanisms. Characteristics and internal features of lava lobes and whole flow field morphologies result from the forward propagation, radial spread, and cooling of individual lobes and are used as a tool to understand the architecture of extensive flood basalt lavas. The features of three flood basalt flow fields from the Columbia River Basalt Group are presented, including the Palouse Falls flow field, a small (8,890 km2, ˜190 km3) unit by common flood basalt proportions, and visualized in three dimensions. The architecture of the Palouse Falls flow field is compared to the complex Ginkgo and more extensive Sand Hollow flow fields to investigate the degree to which simple emplacement models represent the style, as well as the spatial and temporal developments, of flow fields. Evidence from each flow field supports emplacement by inflation as the predominant mechanism producing thick lobes. Inflation enables existing lobes to transmit lava to form new lobes, thus extending the advance and spread of lava flow fields. Minimum emplacement timescales calculated for each flow field are 19.3 years for Palouse Falls, 8.3 years for Ginkgo, and 16.9 years for Sand Hollow. Simple flow fields can be traced from vent to distal areas and an emplacement sequence visualized, but those with multiple-layered lobes present a degree of complexity that make lava pathways and emplacement sequences more difficult to identify.

Lunar mare deposits associated with the Orientale impact basin: New insights into mineralogy, history, mode of emplacement, and relation to Orientale Basin evolution from Moon Mineralogy Mapper (M3) data from Chandrayaan-1

USGS Publications Warehouse

Whitten, J.; Head, J.W.; Staid, M.; Pieters, C.M.; Mustard, J.; Clark, R.; Nettles, J.; Klima, R.L.; Taylor, L.

2011-01-01

Moon Mineralogy Mapper (M3) image and spectral reflectance data are combined to analyze mare basalt units in and adjacent to the Orientale multiring impact basin. Models are assessed for the relationships between basin formation and mare basalt emplacement. Mare basalt emplacement on the western nearside limb began prior to the Orientale event as evidenced by the presence of cryptomaria. The earliest post-Orientale-event mare basalt emplacement occurred in the center of the basin (Mare Orientale) and postdated the formation of the Orientale Basin by about 60-100 Ma. Over the next several hundred million years, basalt patches were emplaced first along the base of the Outer Rook ring (Lacus Veris) and then along the base of the Cordillera ring (Lacus Autumni), with some overlap in ages. The latest basalt patches are as young as some of the youngest basalt deposits on the lunar nearside. M3 data show several previously undetected mare patches on the southwestern margins of the basin interior. Regardless, the previously documented increase in mare abundance from the southwest toward the northeast is still prominent. We attribute this to crustal and lithospheric trends moving from the farside to the nearside, with correspondingly shallower density and thermal barriers to basaltic magma ascent and eruption toward the nearside. The wide range of model ages for Orientale mare deposits (3.70-1.66 Ga) mirrors the range of nearside mare ages, indicating that the small amount of mare fill in Orientale is not due to early cessation of mare emplacement but rather to limited volumes of extrusion for each phase during the entire period of nearside mare basalt volcanism. This suggests that nearside and farside source regions may be similar but that other factors, such as thermal and crustal thickness barriers to magma ascent and eruption, may be determining the abundance of surface deposits on the limbs and farside. The sequence, timing, and elevation of mare basalt deposits suggest that regional basin-related stresses exerted control on their distribution. Our analysis clearly shows that Orientale serves as an excellent example of the early stages of the filling of impact basins with mare basalt. Copyright ?? 2011 by the American Geophysical Union.

Integrating Growth Stage Deficit Irrigation into a Process Based Crop Model

NASA Technical Reports Server (NTRS)

Lopez, Jose R.; Winter, Jonathan M.; Elliott, Joshua; Ruane, Alex C.; Porter, Cheryl; Hoogenboom, Gerrit

2017-01-01

Current rates of agricultural water use are unsustainable in many regions, creating an urgent need to identify improved irrigation strategies for water limited areas. Crop models can be used to quantify plant water requirements, predict the impact of water shortages on yield, and calculate water productivity (WP) to link water availability and crop yields for economic analyses. Many simulations of crop growth and development, especially in regional and global assessments, rely on automatic irrigation algorithms to estimate irrigation dates and amounts. However, these algorithms are not well suited for water limited regions because they have simplistic irrigation rules, such as a single soil-moisture based threshold, and assume unlimited water. To address this constraint, a new modeling framework to simulate agricultural production in water limited areas was developed. The framework consists of a new automatic irrigation algorithm for the simulation of growth stage based deficit irrigation under limited seasonal water availability; and optimization of growth stage specific parameters. The new automatic irrigation algorithm was used to simulate maize and soybean in Gainesville, Florida, and first used to evaluate the sensitivity of maize and soybean simulations to irrigation at different growth stages and then to test the hypothesis that water productivity calculated using simplistic irrigation rules underestimates WP. In the first experiment, the effect of irrigating at specific growth stages on yield and irrigation water use efficiency (IWUE) in maize and soybean was evaluated. In the reproductive stages, IWUE tended to be higher than in the vegetative stages (e.g. IWUE was 18% higher than the well watered treatment when irrigating only during R3 in soybean), and when rainfall events were less frequent. In the second experiment, water productivity (WP) was significantly greater with optimized irrigation schedules compared to non-optimized irrigation schedules in water restricted scenarios. For example, the mean WP across 38 years of maize production was 1.1 kg/cu m for non-optimized irrigation schedules with 50 mm of seasonal available water and 2.1 kg/cu m optimized ion schedules, a 91% improvement in WP with optimized irrigation schedules. The framework described in this work could be used to estimate WP for regional to global assessments, as well as derive location specific irrigation guidance.

2012/13 abnormal cold winter in Japan associated with Large-scale Atmospheric Circulation and Local Sea Surface Temperature over the Sea of Japan

NASA Astrophysics Data System (ADS)

Ando, Y.; Ogi, M.; Tachibana, Y.

2013-12-01

On Japan, wintertime cold wave has social, economic, psychological and political impacts because of the lack of atomic power stations in the era of post Fukushima world. The colder winter is the more electricity is needed. Wintertime weather of Japan and its prediction has come under the world spotlight. The winter of 2012/13 in Japan was abnormally cold, and such a cold winter has persisted for 3 years. Wintertime climate of Japan is governed by some dominant modes of the large-scale atmospheric circulations. Yasunaka and Hanawa (2008) demonstrated that the two dominant modes - Arctic Oscillation (AO) and Western Pacific (WP) pattern - account for about 65% of the interannual variation of the wintertime mean surface air temperature of Japan. A negative AO brings about cold winter in Japan. In addition, a negative WP also brings about cold winter in Japan. Looking back to the winter of 2012/13, both the negative AO and negative WP continued from October through December. If the previous studies were correct, it would have been extremely very cold from October through December. In fact, in December, in accordance with previous studies, it was colder than normal. Contrary to the expectation, in October and November, it was, however, warmer than normal. This discrepancy signifies that an additional hidden circumstance that heats Japan overwhelms these large-scale atmospheric circulations that cool Japan. In this study, we therefore seek an additional cause of wintertime climate of Japan particularly focusing 2012 as well as the AO and WP. We found that anomalously warm oceanic temperature surrounding Japan overwhelmed influences of the AO or WP. Unlike the inland climate, the island climate can be strongly influenced by surrounding ocean temperature, suggesting that large-scale atmospheric patterns alone do not determine the climate of islands. (a) Time series of a 5-day running mean AO index (blue) as defined by Ogi et al., (2004), who called it the SVNAM index. For reference, the conventional AO index is shown by the gray line. (b) a 5-day running mean WP index, (c) area-averaged Surface Air Temperature anomalies in Japan, (d) Air Temperature anomalies, (e) heat flux anomalies, and (f) Sea Surface Temperature anomalies. The boxed area on the Sea of Japan indicates the area in which the (d)-(f) indexes were calculated.

Mechanisms Of Saucer-Shaped Sill Emplacement: Insight From Experimental Modeling

NASA Astrophysics Data System (ADS)

Galland, O.; Planke, S.; Malthe-Sørenssen, A.; Polteau, S.; Svensen, H.; Podladchikov, Y. Y.

2006-12-01

It has been recently demonstrated that magma intrusions in sedimentary basins had a strong impact on petroleum systems. Most of these intrusions are sills, and especially saucer-shaped sills. These features can be observed in many sedimentary basins (i.e. the Karoo basin, South Africa; the Norwegian and North Sea; the Tunguska basin, Siberia; the Neuquén basin in Argentina). The occurrence of such features in so various settings suggests that their emplacement results from fundamental processes. However, the mechanisms that govern their formation remain poorly constrained. Experiments were conducted to simulate the emplacement of saucer-shaped magma intrusions in sedimentary basins. The model rock and magma were fine-grained silica flour and molten vegetable oil, respectively. This modeling technique allows simultaneous simulation of magma emplacement and brittle deformation at a basin scale. For our purpose, we performed our experiments without external deformation. During the experiments, the oil was injected horizontally at constant flow rate within the silica flour. Then the oil initially emplaced in a sill, whereas the surface of the model inflated into a smooth dome. Subsequently, the oil propagated upwards along inclined sheets, finally reaching the surface at the edge of the dome. The resulting geometries of the intrusions were saucer-shaped sills. Then the oil solidified, and the model was cut in serial cross-sections through which the structures of the intrusive body and of the overburden can be observed. In order to constraint the processes governing the emplacement of such features, we performed a parametric study based on a set of experiments in which we systematically varied parameters such as the depth of emplacement and the injection flow rate of the oil. Our results showed that saucer diameters are larger at deeper level of emplacement. Opposite trend was obtained with varying injection flow rates. Based on our results, we conducted a detailed physical analysis that resulted in the definition of a dimensionless parameter that governs the emplacement of saucers.

Emplacement of Pahoehoe Toe Networks: Observations of May, 2010 Tube-fed Flows at Kilauea Volcano, Hawai'i

NASA Astrophysics Data System (ADS)

Crown, D. A.; Ramsey, M.; Hon, K.

2010-12-01

Pahoehoe lava flows are compound features that consist of multiple overlapping and interfingering lobes and exhibit morphologically diverse surfaces characterized by channelized zones, smooth-surfaced sheets, and numerous, small toe networks. Previous work compiled detailed planform maps of solidified pahoehoe toe networks to document their morphology, morphometry and connective relationships in order to provide constraints on lava transport models. In order to expand this research to active flow emplacement, we observed slow-moving, tube-fed pahoehoe flows on the coastal plain near Kalapana, Hawaii in May, 2010. The evolution of pahoehoe toe and toe network characteristics over their emplacement history was examined and the role of small-scale flow inflation on the advance of pahoehoe lobes evaluated. We collected both visible video footage and high-speed, high-precision thermal infrared (TIR) data using a FLIR S-40 camera. The TIR data provide surface temperature maps that can be easily used to identify formation of new toes and track their growth and surface cooling. From these maps, lobe development, connective relationships, and frontal and lateral spreading rates can be analyzed. Preliminary results suggest that regular cycles of activity characterize the development of these pahoehoe lobes: 1) emplacement of new toes in local topographic lows at the front, margin, and within the interior of an active lobe forming small interconnected networks, 2) decline and sometimes temporary cessation in the production of new pahoehoe toes, 3) inflation of the recently emplaced flow surface, either partially or en masse depending on the rate of influx of new lava, the degree of irregularity of the pre-flow surface, and/or the slope across the recently emplaced lava surface, and 4) fracturing of the recently emplaced surface crust that feeds emplacement of new toes. Inflation fractures typically cut across several previously emplaced toes and can occur at the front, along the margins, or within the active lobe, even at significant distances behind the flow front.

Propagation of dikes at Vesuvio (Italy) and the effect of Mt. Somma

NASA Astrophysics Data System (ADS)

Acocella, V.; Porreca, M.; Neri, M.; Massimi, E.; Mattei, M.

2006-04-01

Dikes provide crucial information on how magma propagates within volcanoes. Somma-Vesuvio (Italy) consists of the active Vesuvio cone, partly bordered by the older Mt. Somma edifice. Historical chronicles on the fissure eruptions in 1694-1944 are matched with an analytical solution to define the propagation path of the related dikes and to study any control of the Mt. Somma relief. The fissures always consisted of the downslope migration of vents from an open summit conduit, indicating lateral propagation as the predominant mechanism for shallow dike emplacement. No fissure emplaced beyond Mt. Somma, suggesting that its buttressing hinders the propagation of the radial dikes. An analytical solution is defined to describe the mechanism of formation of the laterally propagating dikes and to evaluate the effect of topography. The application to Somma-Vesuvio suggests that, under ordinary excess magmatic pressures, the dikes should not propagate laterally at depths >240-480 m below the surface, as the increased lithostatic pressure requires magmatic pressures higher than average. This implies that, when the conduit is open, the lateral emplacement of dikes is expectable on the S, W and E slopes. The lack of fissures N of Mt. Somma is explained by its buttressing, which hinders dike propagation.

McClellan PV system installation provides key lessons

NASA Astrophysics Data System (ADS)

Kauffman, W. R.

Design features and lessons learned in the installation of a 40 kWp solar cell array to supply power to a market on an airbase are outlined. The fixed-position modules interface with an inverter, ac and dc switchgear, controls, instrumentation, and an energy management system. The power control unit has a peak power tracking feature to maximize output from the 1142 cell modules. The inverter has functioned at over 98 percent efficiency near the 25 kW design range of the array. Moisture sealing to prevent ground faults was found necessary during the installation of the underground cabling.

Reducing the Footprint: Post Combat Operations, Budget Cuts, and Modern Day Sequestration

DTIC Science & Technology

2013-05-02

That Scary , in One Graph”; The Washington Post; November, 2012; http://www.washingtonpost.com/blogs/wonkblog/wp/2012/11/20/the- sequesters-defense-cuts...arent-that- scary -in-one-graph Figure 1 highlights the ebbs and flows of the DOD budget since the post World War II timeframe. Although the 2011...defense cuts aren’t that scary , in one graph”. The Washington Post, Washington: November, 2012, http://www.washingtonpost.com/blogs/wonkblog/wp

Environmental Fate of White Phosphorus/Felt and Red Phosphorus/Butyl Rubber Military Screening Smokes

DTIC Science & Technology

1985-04-01

Hexametaphosphate ............................. . 109 Fe Phosphite ill.. ~*** ee...*ooO* . 1 C. Biosorption . ... *.* **........ 117 H. Biotransformation Summary...x 10-3 hrŕ and the expected half-life for phosphite is 83 hr. 116 6=9W =NVJV5=*A G, Biosorption Biosorption of WP was conducted using four species...be the primary route of transformation. 117 Y17’ IM Biosorption of WP was found not to be significant for microorganisms. This result parallels the

40 CFR 1045.103 - What exhaust emission standards must my outboard and personal watercraft engines meet?

Code of Federal Regulations, 2010 CFR

2010-07-01

... emission standards must my outboard and personal watercraft engines meet? (a) Duty-cycle emission standards...) Pollutant Power 1 Emission standard HC + NOX P ≤ 4.3 kWP > 4.3 kW 30.0 2.1 + 0.09 × (151 + 557/P0.9) CO P ≤ 40 kWP > 40 kW 500 − 5.0 × P300 1 Power (P) = maximum engine power for the engine family, in...

Effect of upright tilt on ventricular/vascular coupling in chronically instrumented primates

NASA Technical Reports Server (NTRS)

Tran, C. C.; Latham, R. D.; Self, D. A.; Fanton, J. W.; White, C. D.; Owens, R. W.

1993-01-01

Studies of the hydraulic loading conditions on the heart in humans, especially pulsatile load, have primarily been limited to the supine state. Therefore, we have chosen a nonhuman primate model, the baboon, to assess left ventricular/vascular coupling in both supine and upright positions. Primate subjects were studied by catheterization under sedation and then after surgical implantation of transducers. This allowed the evaluation of postural stress in the chronically instrumented conscious baboon and then after light dissociative doses of ketamine. Basic hemodynamic variables were evaluated for baboons in supine and upright positions. Fourier analysis was applied to aortic pressure and flow to obtain input and characteristic impedance and the ratio of pulsatile (Wp) to total (Wt) left ventricular power (Wp/Wt). The aortic reflected, or backward, pressure was also calculated. Peripheral resistance increased (P = 0.01) and reflected pressure decreased (17.74 +/- 1.50 vs. 15.21 +/- 2 mmHg; P < 0.01) in upright subjects. Characteristic impedance and Wp/Wt were unchanged. Postoperatively, peripheral resistance increased (2,651 +/- 311 vs. 3,667 +/- 276; P < 0.05) and mean power and Wt decreased (P < 0.01) without changes in reflected pressure. All variables were unchanged after light dissociative doses of ketamine. Thus there is no significant change in efficiency of left ventricular/vascular coupling formulated in terms of Wp/Wt or input impedance with postural stress.

Nuclear structure and weak rates of heavy waiting point nuclei under rp-process conditions

NASA Astrophysics Data System (ADS)

Nabi, Jameel-Un; Böyükata, Mahmut

2017-01-01

The structure and the weak interaction mediated rates of the heavy waiting point (WP) nuclei 80Zr, 84Mo, 88Ru, 92Pd and 96Cd along N = Z line were studied within the interacting boson model-1 (IBM-1) and the proton-neutron quasi-particle random phase approximation (pn-QRPA). The energy levels of the N = Z WP nuclei were calculated by fitting the essential parameters of IBM-1 Hamiltonian and their geometric shapes were predicted by plotting potential energy surfaces (PESs). Half-lives, continuum electron capture rates, positron decay rates, electron capture cross sections of WP nuclei, energy rates of β-delayed protons and their emission probabilities were later calculated using the pn-QRPA. The calculated Gamow-Teller strength distributions were compared with previous calculation. We present positron decay and continuum electron capture rates on these WP nuclei under rp-process conditions using the same model. For the rp-process conditions, the calculated total weak rates are twice the Skyrme HF+BCS+QRPA rates for 80Zr. For remaining nuclei the two calculations compare well. The electron capture rates are significant and compete well with the corresponding positron decay rates under rp-process conditions. The finding of the present study supports that electron capture rates form an integral part of the weak rates under rp-process conditions and has an important role for the nuclear model calculations.

Sorry doctor, I can't afford the root canal, I have a job: Canadian dental care policy and the working poor.

PubMed

Quiñonez, Carlos; Figueiredo, Rafael

2010-01-01

In Canada, most dental care is privately financed through employment-based insurance, with only a small amount of care supported by governments for groups deemed in social need. Recently, this low level of public financing has been linked to problems in accessing dental care, and one group that has received major attention are the working poor (WP), or those who maintain regular employment but remain in relative poverty. The WP highlight a significant gap in Canadian dental care policy, as they are generally not eligible for either public or private insurance. This is a mixed methods study, comprised of an historical review of Canadian dental care policy and a telephone interview survey of WP Canadian adults. By its very definitions, Canadian dental care policy recognizes the WP as persons with employment, yet incorrectly assumes that they will have ready access to employment-based insurance. In addition, through historically developed biases, it also fails to recognize them as persons in social need. Our telephone survey suggests that this policy approach has important impacts in that oral health and dental care outcomes are significantly mitigated by the presence of dental insurance. Canadian dental care policy should be reassessed in terms of how it determines need in order to close a gap that holds negative consequences for many Canadian families.

Dark side of the Universe after Planck data

NASA Astrophysics Data System (ADS)

Cheng, Cheng; Huang, Qing-Guo

2014-02-01

Recently released Planck data imply a smaller Hubble constant H0 than that from the Hubble Space Telescope project (HST) and a larger percentage of the matter components Ωm compared to the Supernova Legacy Survey (SNLS) in the Λ cold dark matter (CDM) model. In this paper we found that even though the tension on H0 between Planck and HST can be relaxed if the dark radiation is introduced [ΔNeff=0.536-0.224+0.229 at 68% CL from the data sets of Planck+WMAP polarization (WP)+baryon acoustic oscillation (BAO)+the combination of supernova Union2.1 compilation of 580 Supernovae (Union2.1)+HST], Ωm from Planck is still not nicely compatible with that from SNLS. The tensions between Planck and other astrophysical data sets can be significantly relaxed in the wCDM model, and the combination of these data sets prefers a phantomlike dark energy at more than 95% CL: w =-1.15±0.07 and w=-1.16±0.06 at 68% CL from Planck+WP+BAO+Union2.1+HST and Planck+WP+BAO+SNLS+HST, respectively. From the statistical point of view, there is no evidence for a time-evolving equation of state (Δχ2=-0.3 compared to a constant equation of state for the combination of Planck+WP+BAO+SNLS+HST).

The Prandtl Plus Scaling Parameters and Velocity Profile Similarity: Part 2

DTIC Science & Technology

2012-12-01

a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1...ABSTRACT In a previous report (Weyburne, AFRL-RY-WP-TR-2012-0227) it was pointed out that the momentum balance type approach to velocity profile...were NOT similar. It was concluded that the scaling variables discovered by the momentum balance type approach as presently constituted are a

The Control of Multi-Agent Systems (MAS)

DTIC Science & Technology

2004-09-01

Mixes rational (ground state E0 = |↓>) & emotional (excited state E1 = |↑>) • M(I, S) -> shifts agent |↑> or |↓> w/P(1) (Gibson, 1986; Caccioppo...1951): a group is more than sum of parts – Luce & Raiffa (1967): individual rational perspective cannot account for the “social” (viz., game and...deception • Assumption: Reality is bistable with I that is mostly inaccessible 2 9th ICCRTS, Copenhagen, 9/2004 Paradoxes • Rational , Individual: ∑xi

A Multireader Exploratory Evaluation of Individual Pulse Sequence Cancer Detection on Prostate Multiparametric Magnetic Resonance Imaging (MRI).

PubMed

Gaur, Sonia; Harmon, Stephanie; Gupta, Rajan T; Margolis, Daniel J; Lay, Nathan; Mehralivand, Sherif; Merino, Maria J; Wood, Bradford J; Pinto, Peter A; Shih, Joanna H; Choyke, Peter L; Turkbey, Baris

2018-04-25

To determine independent contribution of each prostate multiparametric magnetic resonance imaging (mpMRI) sequence to cancer detection when read in isolation. Prostate mpMRI at 3-Tesla with endorectal coil from 45 patients (n = 30 prostatectomy cases, n = 15 controls with negative magnetic resonance imaging [MRI] or biopsy) were retrospectively interpreted. Sequences (T2-weighted [T2W] MRI, diffusion-weighted imaging [DWI], and dynamic contrast-enhanced [DCE] MRI; N = 135) were separately distributed to three radiologists at different institutions. Readers evaluated each sequence blinded to other mpMRI sequences. Findings were correlated to whole-mount pathology. Cancer detection sensitivity, positive predictive value for whole prostate (WP), transition zone, and peripheral zone were evaluated per sequence by reader, with reader concordance measured by index of specific agreement. Cancer detection rates (CDRs) were calculated for combinations of independently read sequences. 44 patients were evaluable (cases median prostate-specific antigen 6.83 [ range 1.95-51.13] ng/mL, age 62 [45-71] years; controls prostate-specific antigen 6.85 [2.4-10.87] ng/mL, age 65.5 [47-71] years). Readers had highest sensitivity on DWI (59%) vs T2W MRI (48%) and DCE (23%) in WP. DWI-only positivity (DWI+/T2W-/DCE-) achieved highest CDR in WP (38%), compared to T2W-only (CDR 24%) and DCE-only (CDR 8%). DWI+/T2W+/DCE- achieved CDR 80%, an added benefit of 56.4% from T2W-only and of 42% from DWI-only (P < .0001). All three sequences interpreted independently positive gave highest CDR of 90%. Reader agreement was moderate (index of specific agreement: T2W = 54%, DWI = 58%, DCE = 33%). When prostate mpMRI sequences are interpreted independently by multiple observers, DWI achieves highest sensitivity and CDR in transition zone and peripheral zone. T2W and DCE MRI both add value to detection; mpMRI achieves highest detection sensitivity when all three mpMRI sequences are positive. Published by Elsevier Inc.

Impaired sequential and partially compensated probabilistic skill learning in Parkinson's disease.

PubMed

Kemény, Ferenc; Demeter, Gyula; Racsmány, Mihály; Valálik, István; Lukács, Ágnes

2018-06-08

The striatal dopaminergic dysfunction in Parkinson's disease (PD) has been associated with deficits in skill learning in numerous studies, but some of the findings remain controversial. Our aim was to explore the generality of the learning deficit using two widely reported skill learning tasks in the same group of Parkinson's patients. Thirty-four patients with PD (mean age: 62.83 years, SD: 7.67) were compared to age-matched healthy adults. Two tasks were employed: the Serial Reaction Time Task (SRT), testing the learning of motor sequences, and the Weather Prediction (WP) task, testing non-sequential probabilistic category learning. On the SRT task, patients with PD showed no significant evidence for sequence learning. These results support and also extend previous findings, suggesting that motor skill learning is vulnerable in PD. On the WP task, the PD group showed the same amount of learning as controls, but they exploited qualitatively different strategies in predicting the target categories. While controls typically combined probabilities from multiple predicting cues, patients with PD instead focused on individual cues. We also found moderate to high correlations between the different measures of skill learning. These findings support our hypothesis that skill learning is generally impaired in PD, and can in some cases be compensated by relying on alternative learning strategies. © 2018 The Authors. Journal of Neuropsychology published by John Wiley & Sons Ltd on behalf of British Psychological Society.

Similarities in basalt and rhyolite lava flow emplacement processes

NASA Astrophysics Data System (ADS)

Magnall, Nathan; James, Mike; Tuffen, Hugh; Vye-Brown, Charlotte

2016-04-01

Here we use field observations of rhyolite and basalt lava flows to show similarities in flow processes that span compositionally diverse lava flows. The eruption, and subsequent emplacement, of rhyolite lava flows is currently poorly understood due to the infrequency with which rhyolite eruptions occur. In contrast, the emplacement of basaltic lava flows are much better understood due to very frequent eruptions at locations such as Mt Etna and Hawaii. The 2011-2012 eruption of Cordón Caulle in Chile enabled the first scientific observations of the emplacement of an extensive rhyolite lava flow. The 30 to 100 m thick flow infilled a topographic depression with a negligible slope angle (0 - 7°). The flow split into two main channels; the southern flow advanced 4 km while the northern flow advanced 3 km before stalling. Once the flow stalled the channels inflated and secondary flows or breakouts formed from the flow front and margins. This cooling rather than volume-limited flow behaviour is common in basaltic lava flows but had never been observed in rhyolite lava flows. We draw on fieldwork conducted at Cordón Caulle and at Mt Etna to compare the emplacement of rhyolite and basaltic flows. The fieldwork identified emplacement features that are present in both lavas, such as inflation, breakouts from the flow font and margins, and squeeze-ups on the flow surfaces. In the case of Cordón Caulle, upon extrusion of a breakout it inflates due to a combination of continued lava supply and vesicle growth. This growth leads to fracturing and breakup of the breakout surface, and in some cases a large central fracture tens of metres deep forms. In contrast, breakouts from basaltic lava flows have a greater range of morphologies depending on the properties of the material in the flows core. In the case of Mt Etna, a range of breakout morphologies are observed including: toothpaste breakouts, flows topped with bladed lava as well as breakouts of pahoehoe or a'a lava. This range in breakout morphologies is in stark contrast to breakouts observed at Cordón Caulle. We also compare the cooled crusts that form on the surface of the flows; in basalts this is of order tens of centimetres thick, in rhyolite flows the crust is of order several metres thick (based on field observations and theoretical values). This surface crust may control the flow advance in the latter phases of the flow evolution, causing stalling of the flow front and subsequent breakout formation. The similarities in flow features between compositional end members hints at a more universal model for lava flow emplacement.

A lunar/Martian anchor emplacement system

NASA Astrophysics Data System (ADS)

Clinton, Dustin; Holt, Andrew; Jantz, Erik; Kaufman, Teresa; Martin, James; Weber, Reed

On the Moon or Mars, it is necessary to have an anchor, or a stable, fixed point able to support the forces necessary to rescue a stuck vehicle, act as a stake for a tent in a Martian gale, act as a fulcrum in the erection of general construction poles, or support tent-like regolith shields. The anchor emplacement system must be highly autonomous. It must supply the energy and stability for anchor deployment. The goal of the anchor emplacement system project is to design and build a prototype anchor and to design a conceptual anchor emplacement system. Various anchors were tested in a 1.3 cubic meter test bed containing decomposed granite. A simulated lunar soil was created by adjusting the moisture and compaction characteristics of the soil. We conducted tests on emplacement torque, amount of force the anchor could withstand before failure, anchor pull out force at various angles, and soil disturbances caused by placing the anchor. A single helix auger anchor performed best in this test bed based on energy to emplace, and the ultimate holding capacity. The anchor was optimized for ultimate holding capacity, minimum emplacement torque, and minimum soil disturbance in sandy soils yielding the following dimensions: helix diameter (4.45 cm), pitch (1.27 cm), blade thickness (0.15 cm), total length (35.56 cm), shaft diameter (0.78 cm), and a weight of 212.62 g. The experimental results showed that smaller diameter, single-helix augers held more force than larger diameter augers for a given depth. The emplacement system consists of a flywheel and a motor for power, sealed in a protective box supported by four legs. The flywheel system was chosen over a gear system based on its increased reliability in the lunar environment.

Pyroclastic Flow (Post-)Emplacement Thermal History Derived From Titanomagnetite Curie Temperatures: Mt. St. Helens and Soufrière Hills as Test Cases

NASA Astrophysics Data System (ADS)

Bowles, J.; Jackson, M.; Lappe, S. C. L. L.; Solheid, P.; Stinton, A. J.

2014-12-01

Pumice blocks and ash matrix sampled from the 1980 pyroclastic flows at Mt. St. Helens and the 2010 flow at Soufrière Hills, Montserrat, display magnetic Curie temperatures (TC) that vary strongly with depth in the flow. We demonstrate that these TC variations result from variable degrees of cation ordering within Mg- and Al-bearing titanomagnetites, and that the degree of ordering is dependent on the emplacement temperature and post-emplacement thermal history of the sample. Curie temperatures are lowest at the tops of flows where rapid cooling has quenched in a relatively low degree of cation order. Samples that cooled more slowly at depth in the flow evolved towards a higher degree of cation order with a correspondingly higher TC. Isothermal annealing experiments in the laboratory have allowed us to document the time-temperature evolution of the cation ordering and Curie temperature, and we use this data in combination with conductive cooling calculations to forward model stratigraphic variations in TC as a function of emplacement temperature (e.g., Fig.1). Preliminary results show that modeled emplacement temperatures (Templ) are reasonably close to measured or estimated emplacement temperatures. Thermal demagnetization data from lithic clasts incorporated into some flows supports the modeled emplacement temperatures; a low-temperature overprint in the direction of the present-day field is removed at ~Templ. However, the documented variation of TC with thermal history means that care should be taken in interpreting this more traditional lithic-based paleomagnetic paleothermometry data. Modification of Curie and blocking temperatures both during natural cooling and during laboratory thermal treatments could affect lithic-based emplacement temperature estimates.

A lunar/Martian anchor emplacement system

NASA Technical Reports Server (NTRS)

Clinton, Dustin; Holt, Andrew; Jantz, Erik; Kaufman, Teresa; Martin, James; Weber, Reed

1993-01-01

On the Moon or Mars, it is necessary to have an anchor, or a stable, fixed point able to support the forces necessary to rescue a stuck vehicle, act as a stake for a tent in a Martian gale, act as a fulcrum in the erection of general construction poles, or support tent-like regolith shields. The anchor emplacement system must be highly autonomous. It must supply the energy and stability for anchor deployment. The goal of the anchor emplacement system project is to design and build a prototype anchor and to design a conceptual anchor emplacement system. Various anchors were tested in a 1.3 cubic meter test bed containing decomposed granite. A simulated lunar soil was created by adjusting the moisture and compaction characteristics of the soil. We conducted tests on emplacement torque, amount of force the anchor could withstand before failure, anchor pull out force at various angles, and soil disturbances caused by placing the anchor. A single helix auger anchor performed best in this test bed based on energy to emplace, and the ultimate holding capacity. The anchor was optimized for ultimate holding capacity, minimum emplacement torque, and minimum soil disturbance in sandy soils yielding the following dimensions: helix diameter (4.45 cm), pitch (1.27 cm), blade thickness (0.15 cm), total length (35.56 cm), shaft diameter (0.78 cm), and a weight of 212.62 g. The experimental results showed that smaller diameter, single-helix augers held more force than larger diameter augers for a given depth. The emplacement system consists of a flywheel and a motor for power, sealed in a protective box supported by four legs. The flywheel system was chosen over a gear system based on its increased reliability in the lunar environment.

Desferrioxamine in warm reperfusion media decreases liver injury aggravated by cold storage

PubMed Central

Arthur, Peter G; Niu, Xian-Wa; Huang, Wen-Hua; DeBoer, Bastiaan; Lai, Ching Tat; Rossi, Enrico; Joseph, John; Jeffrey, Gary P

2013-01-01

AIM: To evaluate whether desferrioxamine decreases ischemia and perfusion injury aggravated by cold storage (CS) in a rat liver perfusion model. METHODS: Isolated rat livers were kept in CS in University of Wisconsin Solution for 20 h at 4 °C, then exposed to 25 min of warm ischemia (WI) at 37 °C followed by 2 h of warm perfusion (WP) at 37 °C with oxygenated (95% oxygen and 5% carbon dioxide) Krebs-Henseleit buffer. Desferrioxamine (DFO), an iron chelator, was added at different stages of storage, ischemia and perfusion: in CS only, in WI only, in WP only, in WI and perfusion, or in all stages. Effluent samples were collected after CS and after WI. Perfusate samples and bile were collected every 30 min (0, 0.5, 1, 1.5 and 2 h) during liver perfusion. Cellular injury was assessed by the determination of lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) in the effluent and perfusate samples. Total iron was analysed in the perfusate samples. After WP, the liver was collected for the determination of liver swelling (wet to dry ratio) and liver morphological examination (hematoxylin and eosin staining). RESULTS: Increased CS time caused increased liver dysfunction during WP. After 2 h of WP, liver injury was indicated by increased release of AST (0.5 h CS: 9.4 ± 2.2 U/g liver vs 20 h CS: 45.9 ± 10.8 U/g liver, P < 0.05) and LDH (0.5 h CS: 59 ± 14 U/g liver vs 20 h CS: 297 ± 71 U/g liver, P < 0.05). There was an associated increase in iron release into the perfusate (0.5 h CS: 0.11 ± 0.03 μmoL/g liver vs 20 h CS: 0.58 ± 0.10 μmoL/g liver, P < 0.05) and reduction in bile flow (0.5 h CS: 194 ± 12 μL/g vs 20 h CS: 71 ± 8 μL/g liver, P < 0.05). When DFO was added during WI and WP following 20 h of CS, release of iron into the perfusate was decreased (DFO absent 0.58 ± 0.10 μmoL/g liver vs DFO present 0.31 ± 0.06 μmoL/g liver, P < 0.05), and liver function substantially improved with decreased release of AST (DFO absent 45.9 ± 10.8 U/g liver vs DFO present 8.1 ± 0.9 U/g liver, P < 0.05) and LDH (DFO absent 297 ± 71 U/g liver vs DFO present 56 ± 7 U/g liver, P < 0.05), and increased bile flow (DFO absent 71 ± 8 μL/g liver vs DFO present 237 ± 36 μL/g liver, P < 0.05). DFO was also shown to improve liver morphology after WP. Cellular injury (the release of LDH and AST) was significantly reduced with the addition of DFO in CS medium but to a lesser extent compared to the addition of DFO in WP or WI and perfusion. There was no effect on liver swelling or bile flow when DFO was only added to the CS medium. CONCLUSION: DFO added during WI and perfusion decreased liver perfusion injury aggravated by extended CS. PMID:23429835

Council of Europe Black Sea Area Project: International Cooperation for the Development of Activities Related to Donation and Transplantation of Organs in the Region.

PubMed

Arredondo, E; López-Fraga, M; Chatzixiros, E; Senemaud, B; Brezovsky, P; Carella, C; Ballesté, C; Aydin Mehmet, A; Tomadze, G; Codreanu, I; Sarkissian, A A; Simeonova, M; Nikonenko, A; Zota, V; Gómez, M P; Manyalich, M; Bolotinha, C; Franca, A; Costa, A N; Ott, M-O; Buchheit, K-H

2018-03-01

In 2011, the European Directorate for the Quality of Medicines & Healthcare of the Council of Europe launched a 3-year collaborative project to address the organ shortage and improve access to transplant health services in Council of Europe member states in the Black Sea area (Armenia, Azerbaijan, Bulgaria, Georgia, Moldova, Romania, Turkey, Ukraine, and the Russian Federation) through the development of safe and ethical donation and transplantation programs. Support the development of donation and transplantation programs through close interstate cooperation between national health organizations and relevant stakeholders. Several work packages (WP) were established: WP1, project coordination (European Directorate for the Quality of Medicines & Healthcare); WP2, development and implementation of an effective legislative and financial framework (Czech Republic and France); WP3, establishment of National Transplant Authorities (Italy and Portugal); and WP4, clinical practices (DTI Foundation). Data collection, surveys, and expert visits allowed for the collection of first-hand information from each participant country at national, regional, and hospital levels. Data analysis showed the positive impact of the project represented by a tendency to increase the total donation rates (per million people) in the participant countries (2011 vs 2013): Azerbaijan, +7.3; Armenia, -0.7; Georgia, +3.3; Bulgaria, +0.9; Moldova, +2.5; Ukraine:, +0.8; Romania, +2.3; and Turkey, +2.7. Increases in total donation rates are the result of a number of initiatives in the Black Sea area, including the stepwise implementation of legislative, organizational and institutional country-specific recommendations tailored by the CoE, efforts of the respective Ministries of Health in each country and synergism with other European projects in the region. These countries should invest further in implementing the recommendations that emerged from this project to improve their organ donation and transplantation programs and progress toward self-sufficiency. Copyright © 2017 Elsevier Inc. All rights reserved.

Whole-pelvis, 'mini-pelvis,' or prostate-only external beam radiotherapy after neoadjuvant and concurrent hormonal therapy in patients treated in Radiation Therapy Oncology Group 9413 trial

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roach, Mack; De Silvio, Michelle; Valicenti, Richard

2006-11-01

Purpose: Radiation Therapy Oncology Group (RTOG) 9413 trial demonstrated a better progression-free survival (PFS) with whole-pelvis (WP) radiotherapy (RT) compared with prostate-only (PO) RT. This secondary analysis was undertaken to determine whether 'mini-pelvis' (MP; defined as {>=}10 x 11 cm but <11 x 11 cm) RT resulted in progression-free survival (PFS) comparable to that of WP RT. To avoid a timing bias, this analysis was limited to patients receiving neoadjuvant and concurrent hormonal therapy (N and CHT) in Arms 1 and 2 of the study. Methods and Materials: Eligible patients had a risk of lymph node (LN) involvement >15%. Neoadjuvantmore » and concurrent hormonal therapy (N and CHT) was administered 2 months before and during RT for 4 months. From April 1, 1995, to June 1, 1999, a group of 325 patients were randomized to WP RT + N and CHT and another group of 324 patients were randomized to receive PO RT + N and CHT. Patients randomized to PO RT were dichotomized by median field size (10 x 11 cm), with the larger field considered an 'MP' field and the smaller a PO field. Results: The median PFS was 5.2, 3.7, and 2.9 years for WP, MP, and PO fields, respectively (p = 0.02). The 7-year PFS was 40%, 35%, and 27% for patients treated to WP, MP, and PO fields, respectively. There was no association between field size and late Grade 3+ genitourinary toxicity but late Grade 3+ gastrointestinal RT complications correlated with increasing field size. Conclusions: This subset analysis demonstrates that RT field size has a major impact on PFS, and the findings support comprehensive nodal treatment in patients with a risk of LN involvement of >15%.« less

Clinical Toxicities and Dosimetric Parameters After Whole-Pelvis Versus Prostate-Only Intensity-Modulated Radiation Therapy for Prostate Cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deville, Curtiland, E-mail: deville@uphs.upenn.ed; Both, Stefan; Hwang, Wei-Ting

2010-11-01

Purpose: To assess whether whole-pelvis (WP) intensity-modulated radiation therapy (IMRT) is associated with increased toxicity compared with prostate-only (PO) IMRT. Methods and Materials: We retrospectively analyzed all patients with prostate cancer undergoing definitive IMRT to 79.2 Gy with concurrent androgen deprivation at our institution from November 2005 to May 2007 with a minimum follow-up of 12 months. Thirty patients received initial WP IMRT to 45 Gy in 1.8-Gy fractions, and thirty patients received PO IMRT. Study patients underwent computed tomography simulation and treatment planning by use of predefined dose constraints. Bladder and rectal dose-volume histograms, maximum genitourinary (GU) and gastrointestinalmore » (GI) Radiation Therapy Oncology Group toxicity grade, and late Grade 2 or greater toxicity-free survival curves were compared between the two groups by use of the Student t test, Fisher exact test, and Kaplan-Meier curve, respectively. Results: Bladder minimum dose, mean dose, median dose, volume receiving 5 Gy, volume receiving 20 Gy, volume receiving 40 Gy, and volume receiving 45 Gy and rectal minimum dose, median dose, and volume receiving 20 Gy were significantly increased in the WP group (all p values < 0.01). Maximum acute GI toxicity was limited to Grade 2 and was significantly increased in the WP group at 50% vs. 13% the PO group (p = 0.006). With a median follow-up of 24 months (range, 12-35 months), there was no difference in late GI toxicity (p = 0.884) or in acute or late GU toxicity. Conclusions: Despite dosimetric differences in the volume of bowel, bladder, and rectum irradiated in the low-dose and median-dose regions, WP IMRT results only in a clinically significant increase in acute GI toxicity, in comparison to PO IMRT, with no difference in GU or late GI toxicity.« less

Organization of pERK-immunoreactive cells in trigeminal spinal nucleus caudalis, upper cervical cord, NTS and Pa5 following capsaicin injection into masticatory and swallowing-related muscles in rats.

PubMed

Tsujimura, Takanori; Shinoda, Masamichi; Honda, Kuniya; Hitomi, Suzuro; Kiyomoto, Masaaki; Matsuura, Shingo; Katagiri, Ayano; Tsuji, Kojun; Inoue, Makoto; Shiga, Yoshi; Iwata, Koichi

2011-10-12

Many phosphorylated extracellular signal-regulated kinase (pERK)-immunoreactive (IR) cells are expressed in the trigeminal spinal subnucleus caudalis (Vc), upper cervical spinal cord (C1-C2), nucleus tractus solitarii (NTS) and paratrigeminal nucleus (Pa5) after capsaicin injection into the whisker pad (WP), masseter muscle (MM), digastric muscle (DM) or sternohyoideus muscle (SM). The pERK-IR cells also showed NeuN immunoreactivity, indicating that ERK phosphorylation occurs in neurons. The pERK-IR cells were significantly reduced after intrathecal injection of MEK 1/2 inhibitor PD98059. The pERK-IR cells expressed bilaterally in the Vc and C1-C2 after capsaicin injection into the unilateral DM or SM, whereas unilaterally in the Vc and C1-C2 after unilateral WP or MM injection. After capsaicin injection into the WP or MM, the pERK-IR cell expression in the Vc was restricted rostrocaudally within a narrow area. However, the distribution of pERK-IR cells was more wide spread without a clear peak in the Vc and C1-C2 after capsaicin injection into the DM or SM. In the NTS, the unimodal pERK-IR cell expression peaked at 0-720μm rostral from the obex following capsaicin injection into WP, MM, DM or SM. In the ipsilateral Pa5, many pERK-IR cells were observed following capsaicin injection into the SM. The number of swallows elicited by distilled water administration was significantly smaller after capsaicin injection into the WP, MM or DM but not SM compared to that of vehicle-injected rats. Various noxious inputs due to the masticatory or swallowing-related muscle inflammation may be differentially involved in muscle pain and swallowing reflex activity. Copyright © 2011 Elsevier B.V. All rights reserved.

[Safety and efficacy of polyethylene glycol 3350 plus electrolytes for the treatment of functional constipation in children].

PubMed

Infante Pina, D; Miserachs Barba, M; Segarra Canton, O; Alvarez Beltrán, M; Redecillas Ferreiro, S; Vilalta Casas, R; Nieto Rey, J L

2011-08-01

Polyethylene glycol 3350 plus electrolytes (PEG+E) efficacy has been validated in some studies, but not many have evaluated its safety in children. The aim of our study was to evaluate the safety; renal, malabsorption or excessive production of gas and efficacy of PEG+E treatment in our paediatric population. Fifteen patients who suffered functional constipation (Rome III criteria) were evaluated. Median age was 6.2 years (r 2-9). All patients had normal renal function. PEG+E were administered for 4 weeks (4WP). The mean dose was 0.44 g/kg/day, titrated according to age, weight and response. Urine screens (sodium and osmolality) were performed at the beginning and 4WP. Stool sample NIRA (near-infrared reflectance analysis) and hydrogen breath test analysis samples were performed at 4WP. To analyse the efficacy of the treatment, the number of stools per week and stool form type (Bristol stool scale) were recorded. The number of stools per week was higher after 4 weeks (2.46 ± 0.71 vs 5.29 ± 1.68, P<.001), as well as the stool form score (2.47 ± 1.24 vs 4.5 ± 0.91, P<.001). No statistical differences were obtained between urine sodium and urine osmolality values at the beginning and 4WP. After 4WP the NIRA median values were normal in all patients [fat 4.45% (range (r) 3.6-7.09); nitrogen 0.78% (r 0.4-1); sugars 1.4% (r 0.47-2.35) and water 68% (r 59-74)]. Median breath hydrogen test was 7 ppm (r 2-18). No adverse effects on biochemistry values or gastrointestinal disturbances were observed. PEG+E can be recommended for the treatment of functional constipation in children. Copyright © 2010 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

Wellness partners: design and evaluation of a web-based physical activity diary with social gaming features for adults.

PubMed

Gotsis, Marientina; Wang, Hua; Spruijt-Metz, Donna; Jordan-Marsh, Maryalice; Valente, Thomas William

2013-02-01

The United States is currently in an age of obesity and inactivity despite increasing public awareness and scientific knowledge of detrimental long-term health effects of this lifestyle. Behavior-tracking diaries offer an effective strategy for physical activity adherence and weight management. Furthermore, Web-based physical activity diaries can engage meaningful partners in people's social networks through fun online gaming interactions and generate motivational mechanisms for effective behavioral change and positive health outcomes. Wellness Partners (WP) is a Web-based intervention in the form of a physical activity diary with social networking and game features. Two versions were designed and developed for the purpose of this study-"Diary" only and "Diary+Game". The objectives of this study included pilot testing the research process of this intervention design, implementation, evaluation, and exploring the effectiveness of social gaming features on adult participants' physical activity and anthropometric measures. We conducted a field experiment with randomized crossover design. Assessments occurred at baseline, first follow-up (FU, 5-8 weeks after using one version of WP), and second FU (5-8 weeks of using the other version of WP). In the control condition, participants started with the "Diary" version of WP while in the experimental condition, participants started with the "Diary+Game" version of WP. A total of 54 adults (egos) ages 44-88, and their family and friends (alters) ages 17-69 participated in the study in ego-network groups. Both egos and their alters completed online surveys about their exercise habits. In addition, egos completed anthropometric measurements of BMI, fat percentage, and fat mass by bioimpedance. From October 2009 to May 2010, flyers, emails, and Web advertisements yielded 335 volunteers who were screened. Rolling recruitment resulted in enrollment of 142 qualified participants in 54 ego-network groups, which were randomly assigned to a study condition. The final analytic sample included 87 individuals from 41 groups. Data were collected from December 2009 to August 2010, and data analysis was completed in 2011. Overall, the participants were given access to the intervention for 10-13 weeks. Statistical analysis suggested an increase in self-reported exercise frequency (mean days per week) from baseline (2.57, SD 1.92) to first FU (3.21, SD 1.74) in both conditions. Stronger effects were seen in the condition where Diary+Game was played first, especially in network groups with larger age variation between the alters and egos. Overall, the decrease in egos' BMI was statistically significant from baseline to first FU, with greater decrease for those in the Diary+Game first condition (-0.26 vs -0.16 in the Diary first condition). The Wellness Partners program increased physical activity among participants and resulted in health benefits among the egos. Web-based diary interventions designed with social gaming features hold potential to promote active lifestyles for middle-age adults and people in their social networks.

VIEW OF GUN EMPLACEMENT AND THE TABLELIKE CAST CONCRETE STRUCTURE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF GUN EMPLACEMENT AND THE TABLE-LIKE CAST CONCRETE STRUCTURE SHOWING THE SPALLED AREA ON ITS EAST SIDE (LEFT) WHERE THE SECOND PROJECTING ARM WAS BROKEN OFF. NOTE THE SLOPED CONCRETE PAD IN THE BACKGROUND. VIEW FACING SOUTHWEST - U.S. Naval Base, Pearl Harbor, Ford Island 5-Inch Antiaircraft Battery, East Gun Emplacement, Ford Island, Pearl City, Honolulu County, HI

Presentations - Lande, Lauren and others, 2015 | Alaska Division of

Science.gov Websites

Details Title: A petrological model for emplacement of the ultramafic Ni-Cu-PGE Alpha complex, eastern , Newberry, R.J., and Twelker, Evan, 2015, A petrological model for emplacement of the ultramafic Ni-Cu-PGE Sheets Maps & Other Oversized Sheets Sheet 1 A petrological model for emplacement of the ultramafic

Final Environmental Assessment Addressing Construction, Operation, and Maintenance of a Hot Cargo Pad at Kirtland Air Force Base, New Mexico

DTIC Science & Technology

2011-01-01

ground surface of the pad. The surface sludge at WP-26 is currently being removed, which would alleviate any potential adverse effects on the...removing and disposing of the top 5 inches of the ground surface , which is potentially contaminated sewage sludge, within WP-26 in a manner consistent...Construction, Operation, and Maintenance of a Hot Cargo Pad at Kirtland Air Force Base, New Mexico, to identifY and evaluate potential environmental effects

Radical Islam’s Western Foothold: Hugo Chavez and Hezbollah

DTIC Science & Technology

2010-04-01

drugs for Satan – America and the Jews. If we cannot kill them with guns we will kill them with drugs.”43 Iran has also been linked to similar...gruities. They were reported to contain a very obvious lack of basic knowledge of Islam, going so far as to post quotations from the Bible rather than the...wp/ 2009/wp09190. pdf >. Alsema, Adriaan. “Authorities Smash Drug Ring with Hezbollah Ties.” Colombia Reports. 21 Oct. 2008: Web. 3 Nov. 2009

Aircraft Measurements for Understanding Air-Sea Coupling and Improving Coupled Model Predictions

DTIC Science & Technology

2013-09-30

physical parameterizations of the coupled model in various large-scale forcing conditions. OBJECTIVES The NOAA WP-3D efforts of DYNAMO /LASP intend...various phases of the MJO; 3) to extend point measurements on island and ships to a broader area near the DYNAMO region; and 4) To obtain a suite of...upper ocean characteristics from a large number of AXBT/AXCTD data. In addition, as one of the unique measurement strategy of LASP/ DYNAMO WP-3D project

Scales of columnar jointing in igneous rocks: field measurements and controlling factors

NASA Astrophysics Data System (ADS)

Hetényi, György; Taisne, Benoît; Garel, Fanny; Médard, Étienne; Bosshard, Sonja; Mattsson, Hannes B.

2012-03-01

Columnar jointing is a common feature of solidified lavas, sills and dikes, but the factors controlling the characteristic stoutness of columns remain debated, and quantitative field observations are few in number. In this paper, we provide quantitative measurements on sizing of columnar joint sets and our assessment of the principal factors controlling it. We focus on (1) chemistry, as it is the major determinant of the physical (mechanical and thermal) properties of the lava, and (2) geology, as it influences the style of emplacement and lava geometry, setting boundary conditions for the cooling process and the rate of heat loss. In our analysis, we cover lavas with a broad range of chemical compositions (from basanite to phonolite, for six of which we provide new geochemical analyses) and of geological settings. Our field measurements cover 50 columnar jointing sites in three countries. We provide reliable, manually digitized data on the size of individual columns and focus the mathematical analysis on their geometry (23,889 data on side length, of which 17,312 are from full column sections and 3,033 data on cross-sectional area and order of polygonality). The geometrical observations show that the variation in characteristic size of columns between different sites exceeds one order of magnitude (side length ranging from 8 to 338 cm) and that the column-bounding polygons' average order is less than 6. The network of fractures is found to be longer than required by a minimum-energy hexagonal configuration, indicating a non-equilibrium, geologically quick process. In terms of the development and characteristic sizing of columnar joint sets, our observations suggest that columns are the result of an interplay between the geological setting of emplacement and magma chemistry. When the geological setting constrains the geometry of the emplaced body, it exerts a stronger control on characteristic column stoutness. At unconstrained geometries (e.g. unconfined lava flows), chemistry plays the major role, resulting in stouter columns in felsic lavas and slenderer columns in mafic lavas.

U-Pb isotopic evidence for accretion of a continental microplate in the Zalm region of the Saudi Arabian Shield

USGS Publications Warehouse

Stacey, J.S.; Agar, R.A.

1986-01-01

U-Pb zircon age determinations show that this "Andean" continental margin developed before about 720 Ma, and emplacement of calc-alkaline plutonic rocks continued until about 690 Ma. During the period 690-640 Ma, the continental Afif microplate collided with the Asir terrane as part of the Nabitah orogeny. At approximately 640 Ma ago, the Najd strike-slip orogen commenced with a dextral phase that controlled the emplacement of granitic plutons as well as the development of a series of large pull-apart grabens. Some of these grabens were floored by new oceanic crust and were filled with volcano-sedimentary rocks of the Bani Ghayy group. Subsequently, the Najd fault system changed to sinistral strike slip motion at about 620 Ma ago.

Aerial thermal images to assess irrigation efficiency in 'Vitis vinifera' cv. Albariño

NASA Astrophysics Data System (ADS)

Gonzalez, Xesús Pablo; Fandiño, María; Rey, Benjamín J.; José Cancela, Javier

2017-04-01

Canopy temperature was defined as key data to irrigation management and to detect crop water stress (Jackson, 1982). Recently, temperature camera was installed on board in a Unmanned Aerial Vehicle (UAV), thus heterogeneity within field could be determined. Pereira et al. (2012) have defined the conceptual and terminological study of crop water use indicators, mainly water use efficiency (WUE) and water productivity (WP). Actually, it is crucial achieve higher WP and WUE, where crop yield variability between years must be reduced with the smallest irrigation water, but with a correct management of crop water stress during the season. In this study, Albariño cultivar grapevine, priority in Galicia (Spain) in Designation of Origen 'Rías Baixas', was assessed in relation to water productivity index, focus on irrigation treatments aspects, during 2016. Albariño vineyard was planted in 1996 on 110-Richter at a spacing of 3 × 2 m (1667 vines ha-1) (41°57 6 N, 8°49 26 W, elevation 101 m). Vines were trained to a vertical trellis system on a Guyot oriented in the East-West direction. Three irrigation treatments were applied: irrigation from budburst to maturation (T1), from flowering to maturation (T2), and from veraison to maturation (T3), moreover a rain-fed treatment was implemented. All WP index was referred to farm yield level (kg ha-1); where the denominator applied to WP TWUfarm, introduced rainfall and irrigation depth; to WP Irrig, only irrigation depth applied; was used. Moreover, crop water stress index (CWSI) was used to determine homogenize areas within experimental plot, using an UAV with a thermal camera (ThermoMAP, senseFly, SW) to achieve a final map with 14 cm per pixel resolution. During August 11th, at the end of veraison, camera was installed in an 'eBee Ag' UAV (senseFly, SW) with a median flight altitude of 75 m over ground level. Yield per hectare were recorded and total irrigation depth per treatment during the growing season from March to harvest. Preliminary results have showed that CWSI is useful to determine heterogeneity areas within field, concretely areas with identic irrigation treatments were grouped in a similar range, a good correlation was achieved with steam water potential measured in verasion during the flight. This aspect permit establishes a tool to manage irrigation with efficiency, during the growing season, using thermal data and CWSI. Finally, WP were higher in rain-fed than irrigated treatments, where T3 treatment showed higher WP Irrig, than T1 and T2 treatments. A new step Economic aspects should be studied, taken into account benefit crop yield, and cost of pumping irrigation water. References: Jackson, RD (1982). Canopy temperature and crop water stress. Advances in irrigation, 1:43-85 Pereira LS, Cordery I, Iacovides I (2012). Improved indicators of water use performance and productivity for sustainable water conservation and saving. Agricultural Water Management, 108:39-51

Excimer laser annealing to fabricate low cost solar cells

NASA Technical Reports Server (NTRS)

1984-01-01

The objective is to show whether or not pulsed excimer laser annealing (PELA) of ion-implanted junctions is a cost effective replacement for diffused junctions in fabricating crystalline silicon solar cells. The preliminary economic analysis completed shows that the use of PELA to fabricate both the front junction and back surface field (BSF) would cost approximately 35 cents per peak watt (Wp), compared to a cost of 15 cents/Wp for diffusion, aluminum BSF and an extra cleaning step in the baseline process. The cost advantage of the PELA process depends on improving the average cell efficiency from 14% to 16%, which would lower the overall cost of the module by about 15 cents/Wp. An optimized PELA process compatible with commercial production is to be developed, and increased cell efficiency with sufficient product for adequate statistical analysis demonstrated. An excimer laser annealing station was set-up and made operational. The first experiment used 248 nm radiation to anneal phosphorus implants in polished and texture-etched silicon.

Acellular Pertussis Vaccines and Pertussis Resurgence: Revise or Replace?

PubMed Central

Ausiello, Clara Maria

2014-01-01

ABSTRACT The resurgence of pertussis (whooping cough) in countries with high vaccination coverage is alarming and invites reconsideration of the use of current acellular pertussis (aP) vaccines, which have largely replaced the old, reactogenic, whole-cell pertussis (wP) vaccine. Some drawbacks of these vaccines in terms of limited antigenic composition and early waning of antibody levels could be anticipated by the results of in-trial or postlicensure human investigations of B- and T-cell responses in aP versus wP vaccine recipients or unvaccinated, infected children. Recent data in experimental models, including primates, suggest that generation of vaccines capable of a potent, though regulated, stimulation of innate immunity driving effective, persistent adaptive immune responses against Bordetella pertussis infection should be privileged. Adjuvants that skew Th1/Th17 responses or new wP (detoxified or attenuated) vaccines should be explored. Nonetheless, the high merits of the current aP vaccines in persuading people to resume vaccination against pertussis should not be forgotten. PMID:24917600

Physical properties of a resin system for filling the inter-space in the ITER TF coil casing

NASA Astrophysics Data System (ADS)

Evans, D.; Baynahm, E.; Canfer, S.; Foussat, A.

2014-01-01

Each of the eighteen ITER Toroidal Field (TF) coils will consist of seven double pancakes. Each double pancake will have been individually vacuum impregnated and then the seven units assembled together, over-wrapped with glass fabric based insulation and finally vacuum impregnated again to form the TF coil winding pack [1]. The winding pack (WP) will be finally assembled into the coil casing (CC) and to allow for manufacturing tolerances and final geometric definition, a nominal 10 mm gap will exist between the winding pack and the coil case but in practice, this gap may vary between 3 and 15 mm. After assembly, the final step will be to fill the gap with a material that will maintain the final position of the WP and to uniformly transfer load from WP to CC. This paper deals with the selection of materials and techniques to fill the gap and details some of the properties of the chosen material.

Syn-emplacement fracturing in the Sandfell laccolith, eastern Iceland – implications for rhyolite intrusion growth and volcanic hazards

NASA Astrophysics Data System (ADS)

Mattsson, Tobias; Burchardt, Steffi; Almqvist, Bjarne S. G.; Ronchin, Erika

2018-02-01

Felsic magma commonly pools within shallow mushroom-shaped magmatic intrusions, so-called laccoliths or cryptodomes, which can cause both explosive eruptions and collapse of the volcanic edifice. Deformation during laccolith emplacement is primarily considered to occur in the host rock. However, shallowly emplaced laccoliths (cryptodomes) show extensive internal deformation. While deformation of magma in volcanic conduits is an important process for regulating eruptive behavior, the effects of magma deformation on intrusion emplacement remain largely unexplored. In this study, we investigate the emplacement of the 0.57 km3 rhyolitic Sandfell laccolith, Iceland, which formed at a depth of 500 m in a single intrusive event. By combining field measurements, 3D modeling, anisotropy of magnetic susceptibility, microstructural analysis, and FEM modeling we examine deformation in the magma to constrain its influence on intrusion emplacement. Concentric flow bands and S-C fabrics reveal contact-parallel magma flow during the initial stages of laccolith inflation. The magma flow fabric is overprinted by strain-localization bands and more than one third of the volume of the Sandfell laccolith display concentric intensely fractured layers. A dominantly oblate magmatic fabric in the fractured areas and conjugate geometry of strain-localization bands, and fractures in the fracture layers demonstrate that the magma was deformed by intrusive stresses. This implies that a large volume of magma became viscously stalled and was unable to flow during intrusion. Fine-grained groundmass and vesicle-poor rock adjacent to the fracture layers point to that the interaction between the strain-localization bands and the flow bands at sub-solidus state caused the brittle-failure and led to decompression degassing and crystallization and rapid viscosity increase in the magma. The extent of syn-emplacement fracturing in the Sandfell laccolith further shows that strain-induced degassing limited the amount of eruptible magma by essentially solidifying the rim of the magma body. Our observations indicate that syn-emplacement changes in rheology, and the associated fracturing of intruding magma not only occur in volcanic conduits, but also play a major role in the emplacement of viscous magma intrusions in the upper kilometer of the crust.

Gain Coupling of Class A Semiconductor Lasers (Postprint)

DTIC Science & Technology

2010-09-01

Circuits (Wiley, 1995). 15. SimuLase Version 1.4.0.0 by Nonlinear Control Strategies, Inc. (2009). 16. A. Siegman , Lasers (University Science, 1986). 3062 OPTICS LETTERS / Vol. 35, No. 18 / September 15, 2010 3 ...AFRL-RY-WP-TP-2010-1250 GAIN COUPLING OF CLASS A SEMICONDUCTOR LASERS (POSTPRINT) Chris Hessenius, Mahmoud Fallahi, and Jerome Moloney...June 2010 4. TITLE AND SUBTITLE GAIN COUPLING OF CLASS A SEMICONDUCTOR LASERS (POSTPRINT) 5a. CONTRACT NUMBER In-house 5b. GRANT NUMBER 5c

Terrestrial Microcosm Evaluation of Two Army Smoke-Producing Compounds.

DTIC Science & Technology

1988-01-29

a greenhouse under natural or controlled photoperiods (depending on the time of year) with rainfall input simulated. Parameters monitored S ’a. ’ ’a...Sixty intact soil-core microcosms that had been extracted from an undisturbed (for m. iy years) field site were set up in a greenhouse under strict...tests. The 60 cures were divided equally between two greenhouse bays, 30 cores for exposure to RP/BR and 30 cores for exposure to WP. Within each group

Benchmarking computational fluid dynamics models of lava flow simulation for hazard assessment, forecasting, and risk management

USGS Publications Warehouse

Dietterich, Hannah; Lev, Einat; Chen, Jiangzhi; Richardson, Jacob A.; Cashman, Katharine V.

2017-01-01

Numerical simulations of lava flow emplacement are valuable for assessing lava flow hazards, forecasting active flows, designing flow mitigation measures, interpreting past eruptions, and understanding the controls on lava flow behavior. Existing lava flow models vary in simplifying assumptions, physics, dimensionality, and the degree to which they have been validated against analytical solutions, experiments, and natural observations. In order to assess existing models and guide the development of new codes, we conduct a benchmarking study of computational fluid dynamics (CFD) models for lava flow emplacement, including VolcFlow, OpenFOAM, FLOW-3D, COMSOL, and MOLASSES. We model viscous, cooling, and solidifying flows over horizontal planes, sloping surfaces, and into topographic obstacles. We compare model results to physical observations made during well-controlled analogue and molten basalt experiments, and to analytical theory when available. Overall, the models accurately simulate viscous flow with some variability in flow thickness where flows intersect obstacles. OpenFOAM, COMSOL, and FLOW-3D can each reproduce experimental measurements of cooling viscous flows, and OpenFOAM and FLOW-3D simulations with temperature-dependent rheology match results from molten basalt experiments. We assess the goodness-of-fit of the simulation results and the computational cost. Our results guide the selection of numerical simulation codes for different applications, including inferring emplacement conditions of past lava flows, modeling the temporal evolution of ongoing flows during eruption, and probabilistic assessment of lava flow hazard prior to eruption. Finally, we outline potential experiments and desired key observational data from future flows that would extend existing benchmarking data sets.

WAG 2 remedial investigation and site investigation site-specific work plan/health and safety checklist for the sediment transport modeling task

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holt, V.L.; Baron, L.A.

1994-05-01

This site-specific Work Plan/Health and Safety Checklist (WP/HSC) is a supplement to the general health and safety plan (HASP) for Waste Area Grouping (WAG) 2 remedial investigation and site investigation (WAG 2 RI&SI) activities [Health and Safety Plan for the Remedial Investigation and Site Investigation of Waste Area Grouping 2 at the Oak Ridge National Laboratory, Oak Ridge, Tennessee (ORNL/ER-169)] and provides specific details and requirements for the WAG 2 RI&SI Sediment Transport Modeling Task. This WP/HSC identifies specific site operations, site hazards, and any recommendations by Oak Ridge National Laboratory (ORNL) health and safety organizations [i.e., Industrial Hygiene (IH),more » Health Physics (HP), and/or Industrial Safety] that would contribute to the safe completion of the WAG 2 RI&SI. Together, the general HASP for the WAG 2 RI&SI (ORNL/ER-169) and the completed site-specific WP/HSC meet the health and safety planning requirements specified by 29 CFR 1910.120 and the ORNL Hazardous Waste Operations and Emergency Response (HAZWOPER) Program Manual. In addition to the health and safety information provided in the general HASP for the WAG 2 RI&SI, details concerning the site-specific task are elaborated in this site-specific WP/HSC, and both documents, as well as all pertinent procedures referenced therein, will be reviewed by all field personnel prior to beginning operations.« less

Emplacement controls for the basaltic-andesitic radial dikes of Summer Coon volcano and implications for flank vents at stratovolcanoes

NASA Astrophysics Data System (ADS)

Harp, A. G.; Valentine, G. A.

2018-02-01

Mafic flank eruptions are common events that pose a serious hazard to the communities and infrastructure often encroaching on the slopes of stratovolcanoes. Flank vent locations are dictated by the propagation path of their feeder dikes. The dikes are commonly thought to propagate either laterally from the central conduit or vertically from a deeper source. However, these interpretations are often based on indirect measurements, such as surface deformation and seismicity at active systems, and several studies at eroded volcanoes indicate the propagation paths may be more complex. We investigated the Oligocene age Summer Coon volcano (Colorado, USA), where erosion has exposed over 700 basaltic-andesitic radial dikes, to constrain the propagation directions, geometries, and spatial distributions of mafic dikes within a stratovolcano. The mean fabric angle of aligned plagioclase crystals was measured in oriented samples from the margins of 77 dikes. Of the 41 dikes with statistically significant flow fabrics, 85% had fabric angles that were inclined—plunging both inward and outward relative to the center of the volcano. After comparing fabric angles to those reported in other studies, we infer that, while most of the dikes with outward-plunging fabrics descended toward the flanks from a source within the edifice and near its axis, dikes with inward-plunging fabrics ascended through the edifice and toward the flanks from a deeper source. A possible control for the inclination of ascending dikes was the ratio between magma overpressure and the normal stress in the host rock. While higher ratios led to high-angle propagation, lower ratios resulted in inclined emplacement. Dikes crop out in higher frequencies within a zone surrounding the volcano axis at 2500 m radial distance from the center and may be the result of ascending dikes, emplaced at similar propagation angles, intersecting the current level of exposure at common distances from the volcano axis. The process of inclined dike emplacement may be common at other stratovolcanoes and should be considered from a monitoring and hazard perspective as slight variations in the propagation angle would translate to major shifts in the anticipated vent location.

Control of Precambrian basement deformation zones on emplacement of the Laramide Boulder batholith and Butte mining district, Montana, United States

USGS Publications Warehouse

Berger, Byron R.; Hildenbrand, Thomas G.; O'Neill, J. Michael

2011-01-01

What are the roles of deep Precambrian basement deformation zones in the localization of subsequent shallow-crustal deformation zones and magmas? The Paleoproterozoic Great Falls tectonic zone and its included Boulder batholith (Montana, United States) provide an opportunity to examine the importance of inherited deformation fabrics in batholith emplacement and the localization of magmatic-hydrothermal mineral deposits. Northeast-trending deformation fabrics predominate in the Great Falls tectonic zone, which formed during the suturing of Paleoproterozoic and Archean cratonic masses approximately 1,800 mega-annum (Ma). Subsequent Mesoproterozoic to Neoproterozoic deformation fabrics trend northwest. Following Paleozoic through Early Cretaceous sedimentation, a Late Cretaceous fold-and-thrust belt with associated strike-slip faulting developed across the region, wherein some Proterozoic faults localized thrust faulting, while others were reactivated as strike-slip faults. The 81- to 76-Ma Boulder batholith was emplaced along the reactivated central Paleoproterozoic suture in the Great Falls tectonic zone. Early-stage Boulder batholith plutons were emplaced concurrent with east-directed thrust faulting and localized primarily by northwest-trending strike-slip and related faults. The late-stage Butte Quartz Monzonite pluton was localized in a northeast-trending pull-apart structure that formed behind the active thrust front and is axially symmetric across the underlying northeast-striking Paleoproterozoic fault zone, interpreted as a crustal suture. The modeling of potential-field geophysical data indicates that pull-apart?stage magmas fed into the structure through two funnel-shaped zones beneath the batholith. Renewed magmatic activity in the southern feeder from 66 to 64 Ma led to the formation of two small porphyry-style copper-molybdenum deposits and ensuing world-class polymetallic copper- and silver-bearing veins in the Butte mining district. Vein orientations parallel joints in the Butte Quartz Monzonite that, in turn, mimic Precambrian deformation fabrics found outside the district. The faults controlling the Butte veins are interpreted to have formed through activation under shear of preexisting northeast-striking joints as master faults from which splay faults formed along generally east-west and northwest joint plane orientations.

Effects of Plinian Eruptions of Somma-vesuvius On People, Animals, Structures and Objects: Inferences From Avellino (3760 Yr B.p.) and Pompei (79 A.d.) Events.

NASA Astrophysics Data System (ADS)

Mastrolorenzo, G.; Petrone, P. P.; Geraci, G.; Guarino, F.; Incoronato, A.

An interdisciplinary approach to the archaeological sites affected by Avellino (3750 yr. B.P.) and Pompei (79 A.D.) plinian eruptions of Somma-Vesuvius provides new data relative to the depositional mechanisms. Large scale stratigraphy and local evi- dences provide new informations about the physical conditions at the emplacement of PDCs and their effects on structures, people and environment. Field evidences indicate that fine grained pyroclastic deposits related to the column collapses propagate up to a distance of about 15 km from the crater and emplaced with conspicuous thickness. In both Avellino and Pompei eruptions, direct evidences from archaeological sites in- dicate that the emplacement in intermediate and distal areas was relatively quite (low mechanical energy). The recognition of thin, continuous, fine grained surge deposits up to a distance of ca. 15 km from the crater suggests that turbulence was important and the PDCs advanced as a relatively thick dilute current, very poorly controlled by the topography. Furthermore, due to the very small sizes, the particles were always transported in suspension, even at very low current velocity, thus avoiding vertical grading to occur. However, due to the very high depositional mass rate, the emplace- ment was very rapid causing buildings and hut, objects, animals and people to be engulfed within the ash deposits thus preserving their original position, as seen at Herculaneum, Oplontis, Pompeii (79 AD) and Nola (3760 bp). The skeletons of hu- man as well animal victims show high temperature effects. In particular, microscopic bones texture of the victims in the sites affected by the 79 A.D are consistent with very high temperatures, which are anomalous in pyroclastic surge clouds.

Structure of the Castillo granite, Southwest Spain: Variscan deformation of a late Cadomian pluton

NASA Astrophysics Data System (ADS)

EguíLuz, L.; Apraiz, A.; ÁBalos, B.

1999-12-01

A geometrical reconstruction of the 500 Ma old Castillo granite pluton (SW Iberia) is completed on the basis of structural and geophysical (rock magnetism) techniques. The pluton is intrusive into latest Proterozoic-earliest Cambrian metasediments and conforms a tabular intrusion 6 km in diameter and 1.7 km thick that was emplaced at a depth of 10 km. Its magnetic fabric reveals that the strike of moderately to steeply dipping magmatic flow planes forms a high angle to the regional tectonic trends. Magnetic foliations and associated moderately to gently plunging magnetic lineations represent magmatic flow planes and directions. The internal anisotropy of the granite together with the structure shown by the country rocks attest the lateral propagation of the pluton and its latter inflation. The pluton's root zone would correspond to a likely thin, subvertical feeder structure initiated near the orientation of regional σ1 at the time of emplacement. During the Variscan orogeny the pluton was tilted and underwent localized brittle-ductile strain in relation to shear zone deformation in the footwall of a major ductile thrust. Tilting permits the observation and study of a vertical profile of the intrusion. Localized deformation caused superposition of tectonic zonations on the magmatic ones, a reactivation of the basal contact of the pluton, and dismemberment from its root. This and other granitoid plutons of similar age emplaced at a similar depth constrained the creation of crustal mechanical heterogeneity and anisotropy. This controlled the site of pluton emplacement, the nucleation of a major ductile thrust, and localization of deformation and tectonic displacements along the pluton margins during later orogenic reactivation.

Characteristics and Significance of Magma Emplacement Horizons, Black Sturgeon Sill, Nipigon, Ontario

NASA Astrophysics Data System (ADS)

Zieg, M. J.; Hone, S. V.

2017-12-01

Spatial scales strongly control the timescales of processes in igneous intrusions, particularly through the thermal evolution of the magma, which in turn governs the evolution of crystallinity, viscosity, and other important physical and chemical properties of the system. In this study, we have collected a highly detailed data set comprising geochemical (bulk rock composition), textural (size and alignment of plagioclase crystals), and mineralogical (modal abundance) profiles through the central portion of the 250 m thick Black Sturgeon diabase sill. In this data, we have identified characteristic signals in texture (soft and somewhat diffuse chills), composition (reversals in differentiation trends), and mineralogy (olivine accumulations), all coinciding and recurring at roughly 10 meter intervals. Based on these signatures, we are able to map out multiple zones representing discrete pulses of magma that were emplaced sequentially as the intrusion was inflated. Simple thermal calculations suggest that each 10 meters of new crystallization would require repose times on the order of 10-100 years. To build up 250 meters of magma at this rate would only require approximately 250-2500 years, significantly less than the thermal lifetime of the entire sill. The soft chills we observe in the Black Sturgeon sill are therefore consistent with a system that remained warm throughout the emplacement process. Successive pulses were injected into partially crystalline mush, rather than pure liquid (which would result in hybridization) or solid (which would produce sharp hard chills). Episodic emplacement is by now widely recognized as a fundamental process in the formation of large felsic magma chambers; our results suggest that this also may be an important consideration in understanding the evolution of smaller mafic intrusions.

The coupled geochemistry of Au and As in pyrite from ore deposits and geothermal fields: monitoring fluid evolution and external forcing factors in hydrothermal systems

NASA Astrophysics Data System (ADS)

Reich, M.; Deditius, A.; Tardani, D.; Sanchez-Alfaro, P.

2014-12-01

Among the many factors influencing the complex process of lava flow emplacement, the interaction with the substrate onto which flow is emplaced plays a central role. Lava flows are rarely emplaced onto smooth or regular surfaces. For example, at Kīlauea Volcano, Hawai'i, lava flows regularly flow over solid rock, vegetation, basaltic or silica sand, and man-made materials, including asphalt and concrete. In situ studies of lava-substrate interactions are inherently difficult, and often dangerous, to carry-out, requiring the design of controllable laboratory experiments. We investigate the effects of substrate grain size, cohesion, and roughness on flow mobility and morphology through a series of flow experiments using analog materials and molten basalt. We have developed a series of experiments that allow for adjustable substrate parameters and analyze their effects on lava flow emplacement. The first set of experiments are performed at the Fluids Mechanics Laboratory at the Lamont-Doherty Earth Observatory and focus on two analog materials: polyethylene glycol (PEG), a commercially available wax, and corn syrup. The fluids were each extruded onto a series of scaled substrate beds to replicate the emplacement of lava in a natural environment. Preliminary experiments demonstrated that irregular topography, particularly topography with a height amplitude similar to that of the flow itself, can affect flow morphology, width, and velocity by acting as local barriers or culverts to the fluid. This is expected from observations of fluid flow in natural environments. A follow-up set of experiments will be conducted in Fall 2015 at the Syracuse University (SU) Lava Project Lab. In this set, we will pour molten basalt directly onto a series of substrates representing natural environments found on the Earth and other rocky bodies in the Solar System. These experiments will allow for analysis of the effects of basaltic composition and high temperatures on lava-substrate heat transfer and mechanical interactions. Results will be used to improve current lava flow prediction models as well as increase our understanding of the evolution of volcanic regions on the Earth and other planets.

Investigating lava-substrate interactions through flow experiments with syrup, wax, and molten basalt

NASA Astrophysics Data System (ADS)

Rumpf, M. E.; Lev, E.

2015-12-01

Among the many factors influencing the complex process of lava flow emplacement, the interaction with the substrate onto which flow is emplaced plays a central role. Lava flows are rarely emplaced onto smooth or regular surfaces. For example, at Kīlauea Volcano, Hawai'i, lava flows regularly flow over solid rock, vegetation, basaltic or silica sand, and man-made materials, including asphalt and concrete. In situ studies of lava-substrate interactions are inherently difficult, and often dangerous, to carry-out, requiring the design of controllable laboratory experiments. We investigate the effects of substrate grain size, cohesion, and roughness on flow mobility and morphology through a series of flow experiments using analog materials and molten basalt. We have developed a series of experiments that allow for adjustable substrate parameters and analyze their effects on lava flow emplacement. The first set of experiments are performed at the Fluids Mechanics Laboratory at the Lamont-Doherty Earth Observatory and focus on two analog materials: polyethylene glycol (PEG), a commercially available wax, and corn syrup. The fluids were each extruded onto a series of scaled substrate beds to replicate the emplacement of lava in a natural environment. Preliminary experiments demonstrated that irregular topography, particularly topography with a height amplitude similar to that of the flow itself, can affect flow morphology, width, and velocity by acting as local barriers or culverts to the fluid. This is expected from observations of fluid flow in natural environments. A follow-up set of experiments will be conducted in Fall 2015 at the Syracuse University (SU) Lava Project Lab. In this set, we will pour molten basalt directly onto a series of substrates representing natural environments found on the Earth and other rocky bodies in the Solar System. These experiments will allow for analysis of the effects of basaltic composition and high temperatures on lava-substrate heat transfer and mechanical interactions. Results will be used to improve current lava flow prediction models as well as increase our understanding of the evolution of volcanic regions on the Earth and other planets.

Crustal structure and evolution of the NW Zagros Mountains (Iran): Insights from numerical modeling of the interplay between surface and tectonic processes

NASA Astrophysics Data System (ADS)

Saura, Eduard; Garcia-Castellanos, Daniel; Casciello, Emilio; Vergés, Jaume

2014-05-01

Protracted Arabia-Eurasia convergence resulted in the closure of the >2000 km wide Neo-Tethys Ocean from early Late Cretaceous to Recent. This process was controlled by the structure of the NE margin of the Arabian plate, the NE-dipping oceanic subduction beneath Eurasia, the obduction of oceanic lithosphere and the collision of small continental and volcanic arc domains of the SW margin of Eurasia. The evolution of the Zagros Amiran and Mesopotamian foreland basins is studied in this work along a ~700 km long transect in NW Zagros constrained by field, seismic and published data. We use the well-defined geometries and ages of the Amiran and Mesopotamian foreland basins to estimate the elastic thickness of the lithosphere and model the evolution of the deformation to quantitatively link the topographic, tectonic and sedimentary evolution of the system. Modelling results show two major stages of emplacement. The obduction (pre-collision) stage involves the thin thrust sheets of the Kermanshah complex together with the Bisotun basement. The collision stage corresponds to the emplacement of the basement duplex and associated crustal thickening, coeval to the out of sequence emplacement of Gaveh Rud and Imbricated Zone in the hinterland. The geodynamic model is consistent with the history of the foreland basins, with the regional isostasy model, and with a simple scenario for the surface process efficiency. The emplacement of Bisotun basement during obduction tectonically loaded and flexed the Arabian plate triggering deposition in the Amiran foreland basin. The basement units emplaced during the last 10 My, flexed the Arabian plate below the Mesopotamian basin. During this stage, material eroded from the Simply Folded belt and the Imbricated zone was not enough to fill the Mesopotamian basin, which, according to our numerical model results, required a maximum additional sediment supply of 80 m/Myr. This additional supply had to be provided by an axial drainage system, which can be correlated by the income of paleo-Tigris and paleo-Eufrates rivers transporting sediments from north-westernmost areas.

Magma interaction in the root of an arc batholith

NASA Astrophysics Data System (ADS)

Chapman, T.; Robbins, V.; Clarke, G. L.; Daczko, N. R.; Piazolo, S.

2016-12-01

Fiordland, New Zealand, preserves extensive Cretaceous arc plutons, emplaced into parts of the Delamerian/Ross Orogen. Dioritic to gabbroic material emplaced at mid to lower crustal levels are exposed in the Malaspina Pluton (c. 1.2 GPa) and the Breaksea Orthogneiss (c. 1.8 GPa). Distinct magmatic pulses can be mapped in both of these plutons consistent with cycles of melt advection. Relationships are consistent with predictions from lower crustal processing zones (MASH and hot zones) considered important in the formation of Cordilleran margins. Metamorphic garnet growth is enhanced along magmatic contacts, such as where hornblende gabbronorite is cut by garnet-clinopyroxene-bearing diorite. Such features are consistent with cycles of incremental emplacement, younger magma having induced localised garnet granulite metamorphism in wall rock of older material. Temperature estimates and microstructures preserved in garnet granulite are consistent with sub-solidus, water-poor conditions in both the Malaspina and Breaksea Orthogneiss. The extent and conditions of the metamorphism implies conditions and duration was incapable of partially melting older wall rock material. The nature of interactions in intermediate to basic compositions are assessed in terms of magma genesis in the Cretaceous batholith. Most of the upper crustal felsic I-type magmatism along the margin being controlled by high-pressure garnet-clinopyroxene fractionation.

Commercial formulations of Bacillus thuringiensis for control of Indian meal moth.

PubMed Central

Schesser, J H

1976-01-01

Doses of four commercial formulations and one experimental formulation of Bacillus thuringiensis Berliner were mixed with the diet used to rear colonies of the Indian meal moth Plodia interpunctella (Hübner). Indian meal moth eggs were introduced to the treated diet, and the resultant adult emergence was tabulated. The experimental formulations ranked as follows in efficacy in controlling the Indian meal moth: Dipel (50% lethal concentration [LC50], 25 mg/kg) greater than Bactospeine WP (LC50, 100 mg/kg) greater than Thuricide (LC50, 150 mg/kg) greater than IMC 90007 (LC30, 180 mg/kg) greater than Bactospeine Flowable (LC50, 440 mg/kg). PMID:984828

Commercial formulations of Bacillus thuringiensis for control of Indian meal moth.

PubMed

Schesser, J H

1976-10-01

Doses of four commercial formulations and one experimental formulation of Bacillus thuringiensis Berliner were mixed with the diet used to rear colonies of the Indian meal moth Plodia interpunctella (Hübner). Indian meal moth eggs were introduced to the treated diet, and the resultant adult emergence was tabulated. The experimental formulations ranked as follows in efficacy in controlling the Indian meal moth: Dipel (50% lethal concentration [LC50], 25 mg/kg) greater than Bactospeine WP (LC50, 100 mg/kg) greater than Thuricide (LC50, 150 mg/kg) greater than IMC 90007 (LC30, 180 mg/kg) greater than Bactospeine Flowable (LC50, 440 mg/kg).

Advanced European Network of E-Infrastructures for Astronomy with the SKA

NASA Astrophysics Data System (ADS)

Massardi, Marcella

2017-11-01

Here, I present the AENEAS (Advanced European Network of E-infrastructures for Astronomy with the SKA) project has been funded in the Horizon 2020 Work Programme call "Research and Innovation Actions for International Co-operation on high-end e-infrastructure requirements" supporting the Square Kilometre Array (SKA). INAF is contributing to all the AENEAS working packages and leading the WP5 - Access and Knowledge Creation (WP leader M. Massardi IRA-ARC), participants from IRA (Brand, Nanni, Venturi) ,OACT(Becciani, Costa, Umana), OATS (Smareglia, Knapic, Taffoni)

Smoke and Obscurants; a Health and Environmental Effects Data Base Assessment. A First-Order, Environmental Screening and Ranking of Army Smokes and Obscurants

DTIC Science & Technology

1985-02-01

SCREENING. A. Phosphorus smokes (P) 1. White phosphorus ( NP ) White phosphorus/felt wedges (WP/FW) Plasticized white phosphorus (PWP) White phosphorus...exposure. The oral LD50 value for all phosphorus smokes was estimated as that for orthophosphoric acid.22 When NP or RP are combusted. the reaction...WP and RP smoke types were of insigniflcant toxicity, see Table 8. The TLm96 values for NP and RP were values for orthophosphoric acid,22.26 and the

Analysis of inflated submarine and sub-lacustrine Pahoehoe lava flows using high-resolution bathymetric and lidar data (Invited)

NASA Astrophysics Data System (ADS)

Deschamps, A.; Van Vliet-Lanoe, B.; Soule, S. A.; Allemand, P.; Le Saout, M.; Delacourt, C.

2013-12-01

The summit of the East Pacific Rise (EPR), 16°N, is investigated based -among others- on high-resolution bathymetry acquired using the AUV Aster-X, and photos and videos collected using the submersible Nautile (Ifremer). HR bathymetry reveals submarine tumuli and inflated smooth lava flows at the summit of the ridge, emplaced on sub-horizontal terrains. They are primarily composed of jumbled and lobate flows with occurrences of sheet flows, and pillows close to the flow margins. They are 5 to 15 meters -high, and their surface ranges 0.2 to 1.5 km2. Their surface is either planar or depressed, likely due to lava topographic downdraining during eruption. At their margins, planar slabs of lava, few meters wide, slope down from the top of the flow, at angles ranging 40 to 80°. A series of cracks, 0,5 to 1.5 m deep, separate the horizontal surface of the flow from their inclined flanks. These cracks parallel the sinuous edges of the flows, suggesting the flow flanks tilted outward. Tumuli are also observed. Some of these smooth flows form 80 to 750 m -long sinuous ridges, suggesting the existence of lava tubes. Their morphology indicates that these flows experienced inflationary emplacement styles, but at a much larger scale than Pahoehoe lavas in Hawaii and La Réunion Islands. In these two islands, indeed, inflation structures are typically less than 2 meters high and only several tens of meters in length at maximum, suggesting that their mechanism of emplacement and inflation is significantly different. Conversely, we observe comparable inflation flows in Iceland and in Idaho and Oregon, also emplaced onto sub-horizontal terrains. We use high-resolution aerial photographs and lidar data to investigate their morphology. In the Eastern Snake River Plain (ESRP), quaternary basaltic plains volcanism produced monogenetic coalescent shields, and phreatomagmatic basaltic eruptions that are directly related to proximity of magmatism to the Snake River or Pleistocene lakes. For example, the Hells Half Acres Holocene lava flows, Idaho, display similar morphology as EPR flows, with sheet lavas, flow lobes 5-8 m high and approximately 100 m wide, and pressure ridges. Similar flows are observed in the ESRP: Craters of the Moon, Wapi, and Cerro Grande lava flows for example. In Oregon, Potholes, Devils Garden, Diamond Craters, Deschute River, Owyhee River, Jordan Crater flows are also strictly comparable. In Iceland, Lake Mytvan lava flows, for example, were emplaced in sublacustrine environments, and Budahraun flows in Snaefellness were emplaced at the coast below the sea level. The common point of these presently "aerial" lava flow is their emplacement in lakes, paleo-lakes and river beds, thus in "wet" environment, often controlled by rivers and their tributaries. A more efficient cooling of the lava lobes in wet environment probably triggers the development of strong and plastic margins due to cooling, which resists continued movement of the flow, whereas a thinner margin developing in aerial environment may favor lobe break out when internal pressure rises above the tensile strength of the crust. We propose a theoretical model for these lava flow emplacement on sub-horizontal basement.

Identification of distinct movement patterns in Pacific leatherback turtle populations influenced by ocean conditions.

PubMed

Bailey, Helen; Benson, Scott R; Shillinger, George L; Bograd, Steven J; Dutton, Peter H; Eckert, Scott A; Morreale, Stephen J; Paladino, Frank V; Eguchi, Tomoharu; Foley, David G; Block, Barbara A; Piedra, Rotney; Hitipeuw, Creusa; Tapilatu, Ricardo F; Spotila, James R

2012-04-01

Interactions with fisheries are believed to be a major cause of mortality for adult leatherback turtles (Dermochelys coriacea), which is of particular concern in the Pacific Ocean, where they have been rapidly declining. In order to identify where these interactions are occurring and how they may be reduced, it is essential first to understand the movements and behavior of leatherback turtles. There are two regional nesting populations in the East Pacific (EP) and West Pacific (WP), comprising multiple nesting sites. We synthesized tracking data from the two populations and compared their movement patterns. A switching state-space model was applied to 135 Argos satellite tracks to account for observation error, and to distinguish between migratory and area-restricted search behaviors. The tracking data, from the largest leatherback data set ever assembled, indicated that there was a high degree of spatial segregation between EP and WP leatherbacks. Area-restricted search behavior mainly occurred in the southeast Pacific for the EP leatherbacks, whereas the WP leatherbacks had several different search areas in the California Current, central North Pacific, South China Sea, off eastern Indonesia, and off southeastern Australia. We also extracted remotely sensed oceanographic data and applied a generalized linear mixed model to determine if leatherbacks exhibited different behavior in relation to environmental variables. For the WP population, the probability of area-restricted search behavior was positively correlated with chlorophyll-a concentration. This response was less strong in the EP population, but these turtles had a higher probability of search behavior where there was greater Ekman upwelling, which may increase the transport of nutrients and consequently prey availability. These divergent responses to oceanographic conditions have implications for leatherback vulnerability to fisheries interactions and to the effects of climate change. The occurrence of leatherback turtles within both coastal and pelagic areas means they have a high risk of exposure to many different fisheries, which may be very distant from their nesting sites. The EP leatherbacks have more limited foraging grounds than the WP leatherbacks, which could make them more susceptible to any temperature or prey changes that occur in response to climate change.

The Virtual Institute of Integrated Climate and Landscape Evolution Analyses - ICLEA

NASA Astrophysics Data System (ADS)

Schwab, Markus; Brauer, Achim; Błaszkiewicz, Mirosław; Raab, Thomas; Wilmking, Martin; Blume, Theresa; Iclea Team

2014-05-01

The GFZ, Greifswald University and the Brandenburg University of Technology together with their partner the Polish Academy of Sciences strive for focusing their research capacities and expertise in a Helmholtz Virtual Institute for Integrated Climate and Landscape Evolution Analyses (ICLEA). The Coordination Team is based at the GFZ in Potsdam and consists of a permanent scientific manager and administrative personnel. ICLEA offers young researchers an interdisciplinary and structured education and promote their early independence through coaching and mentoring. Postdoctoral rotation positions at the ICLEA partner institutions ensure mobility of young researchers and promote dissemination of information and expertise between disciplines. Training, Research and Analytical workshops between research partners of the ICLEA virtual institute are another important measure to qualify young researchers. The long-term mission of the Virtual Institute is to provide a substantiated data basis for sustained environmental maintenance based on a profound process understanding at all relevant time scales. Aim is to explore processes of climate and landscape evolution in an historical cultural landscape extending from northeastern Germany into northwestern Poland. The northern-central European lowlands will be facilitated as a natural laboratory providing an ideal case for utilizing a systematic and holistic approach. In ICLEA five complementary work packages (WP) are established according to the key research aspects. WP 1 focus on monitoring mainly hydrology and soil moisture as well as meteorological parameters. WP 2 is linking present day and future monitoring data with the most recent past through analysing satellite images. This WP will further provide larger spatial scales. WP 3-5 focus on different natural archives to obtain a broad variety of high quality proxy data. Tree rings provide sub-seasonal data for the last centuries up to few millennia, varved lake sediments cover the entire research time interval at seasonal to decadal resolution and palaeosoils and geomorphological features also cover the entire period but not continuously and with lower resolution. Complementary information, like climate, tree ecophysiological and limnological data etc., are provided by cooperation with associated partners. Further information about ICLEA: www.iclea.de

Combination of Pneumococcal Surface Protein A (PspA) with Whole Cell Pertussis Vaccine Increases Protection Against Pneumococcal Challenge in Mice

PubMed Central

Ferreira, Daniela M.; Moreno, Adriana T.; Ferreira, Patricia C. D.; Lima, Fernanda A.; Santos, Fernanda L.; Sakauchi, Maria Aparecida; Takata, Célia S.; Higashi, Hisako G.; Raw, Isaías; Kubrusly, Flavia S.; Ho, Paulo L.

2010-01-01

Streptococcus pneumoniae is the leading cause of respiratory acute infections around the world. In Latin America, approximately 20,000 children under 5 years of age die of pneumococcal diseases annually. Pneumococcal surface protein A (PspA) is among the best-characterized pneumococcal antigens that confer protection in animal models of pneumococcal infections and, as such, is a good alternative for the currently available conjugated vaccines. Efficient immune responses directed to PspA in animal models have already been described. Nevertheless, few low cost adjuvants for a subunit pneumococcal vaccine have been proposed to date. Here, we have tested the adjuvant properties of the whole cell Bordetella pertussis vaccine (wP) that is currently part of the DTP (diphtheria-tetanus-pertussis) vaccine administrated to children in several countries, as an adjuvant to PspA. Nasal immunization of BALB/c mice with a combination of PspA5 and wP or wPlow – a new generation vaccine that contains low levels of B. pertussis LPS – conferred protection against a respiratory lethal challenge with S. pneumoniae. Both PspA5-wP and PspA5-wPlow vaccines induced high levels of systemic and mucosal antibodies against PspA5, with similar profile, indicating no essential requirement for B. pertussis LPS in the adjuvant properties of wP. Accordingly, nasal immunization of C3H/HeJ mice with PspA5-wP conferred protection against the pneumococcal challenge, thus ruling out a role for TLR4 responses in the adjuvant activity and the protection mechanisms triggered by the vaccines. The high levels of anti-PspA5 antibodies correlated with increased cross-reactivity against PspAs from different clades and also reflected in cross-protection. In addition, passive immunization experiments indicated that antibodies played an important role in protection in this model. Finally, subcutaneous immunization with a combination of PspA5 with DTPlow protected mice against challenge with two different pneumococcal strains, opening the possibility for the development of a combined infant vaccine composed of DTP and PspA. PMID:20523738

Whole-cell or acellular pertussis vaccination in infancy determines IgG subclass profiles to DTaP booster vaccination.

PubMed

van der Lee, Saskia; Sanders, Elisabeth A M; Berbers, Guy A M; Buisman, Anne-Marie

2018-01-04

Duration of protection against pertussis is shorter in adolescents who have been immunized with acellular pertussis (aP) in infancy compared with adolescents who received whole-cell pertussis (wP) vaccines in infancy, which is related to immune responses elicited by these priming vaccines. To better understand differences in vaccine induced immunity, we determined pertussis, diphtheria, and tetanus (DTaP) vaccine antigen-specific IgG subclass responses in wP- and aP-primed children before and after two successive DTaP booster vaccinations. Blood samples were collected in a cross-sectional study from wP- or aP-primed children before and 1 month after the pre-school DTaP booster vaccination at age 4 years. Blood samples were collected from two different wP- and aP-primed groups of children before, 1 month and 1 year after an additional pre-adolescent Tdap booster at age 9 years. IgG subclass levels against the antigens included in the DTaP vaccine have been determined with fluorescent-bead-based multiplex immunoassays. At 4 years of age, the IgG4 proportion and concentration for pertussis, diphtheria and tetanus vaccine antigens were significantly higher in aP-primed children compared with wP-primed children. IgG4 concentrations further increased upon the two successive booster vaccinations at 4 and 9 years of age in both wP- and aP-primed children, but remained significantly higher in aP-primed children. The pertussis vaccinations administered in the primary series at infancy determine the vaccine antigen-specific IgG subclass profiles, not only against the pertussis vaccine antigens, but also against the co-administered diphtheria and tetanus vaccine antigens. These profiles did not change after DTaP booster vaccinations later in childhood. The different immune response with high proportions of specific IgG4 in some aP-primed children may contribute to a reduced protection against pertussis. ISRCTN65428640; ISRCTN64117538; NTR4089. Copyright © 2017 Elsevier Ltd. All rights reserved.

Erosion risk assessment along coastlines, rivers, and lakes

NASA Astrophysics Data System (ADS)

Eidsvig, Unni; Harbitz, Carl B.; Issler, Dieter; Forsberg, Carl Fredrik; Høydal, Øyvind A.; Glimsdal, Sylfest; Frauenfelder, Regula

2017-04-01

An effect of the expected climate changes is that densely populated areas will be more exposed to natural hazards. There is a rising concern about geotechnical challenges associated with the transition zone between water and land, in particular with regard to erosion. This needs to be considered as part of the climate adaptation strategies in the society and applies to both coastal settlements and to settlements along rivers. Climate change, as reported by the IPCC, includes global warming, sea level rise as well as more precipitation, both with respect to intensity and frequency. A larger number of cities are expected to be affected by floods and with higher frequency. With large floods, the current speed in rivers and hence their erosion potential increases, leading to scouring along riverbanks, where important transport routes and other infrastructure are often located. The frequency and intensity of storm surges are expected to increase, as well as the risk of coastal erosion. In steep terrain, the likelihood of debris flows increases. The project "Multi-scale Erosion Risk under Climate Change" was initiated to prepare for such challenges as well as local climate adaptation. The project is an internal NGI strategic project funded by the Research Council of Norway for the period 2017 - 2019. The project aims to investigate relevant erosive and mass-flow processes in the coastal zone, along rivers, and in lakes. Further, the knowledge and tools to be developed within the project aim to reduce the risk associated with these processes, through appropriate land-use planning and innovative mitigation measures. The project is thematically subdivided into the following five work packages: WP1: Modelling of erosion processes in rivers, at the coast and in mass movements WP2: Floods, debris flows and sediment mobility in complex topography WP3: Coastal hydrodynamic processes WP4: Monitoring, warning and non-physical mitigation measures WP5: Dissemination and knowledge sharing In our contribution, we will give an overview of the ideas and the background of the project and present the first preliminary results.

Differences in social relations between persons with type 2 diabetes and the general population.

PubMed

Hempler, Nana Folmann; Ekholm, Ola; Willaing, Ingrid

2013-06-01

Poor social support and lack of social network are well-established risk factors for morbidity and mortality in general populations. Good social relations, such as social support and network contacts, are associated with better self-management and fewer psychosocial problems in persons with type 2 diabetes. The aim of this study was to investigate whether persons with type 2 diabetes have poorer social relations than the general population. We conducted a cross-sectional survey in three settings: a specialist diabetes clinic (SDC) (n = 1084), a web panel (WP) consisting of persons with type 2 diabetes (n = 1491) and a sample from the 2010 Danish Health and Morbidity Survey, representative of the general population (n = 15,165). We compared social relations using multivariate logistic regression. Compared to the general population, persons with type 2 diabetes more often lived without a partner (SDC, OR 1.75, 95% CI 1.49-2.06; WP, OR 1.64, 95% CI 1.43-1.87), met with family less than once a month (SDC, OR 1.78, 95% CI 1.40-2.27; WP, OR 2.35, 95% CI 1.94-2.84) and were less certain they could count on help from others in case of illness (WP, OR 1.23, 95% CI 1.08-1.41). Our findings suggest that persons with type 2 diabetes have poorer social relations than the general population. From a public health point of view, special attention is needed with regards to strengthening existing networks and establishing alternative networks among persons with type 2 diabetes.

The western Pacific monsoon in CMIP5 models: Model evaluation and projections

NASA Astrophysics Data System (ADS)

Brown, Josephine R.; Colman, Robert A.; Moise, Aurel F.; Smith, Ian N.

2013-11-01

ability of 35 models from the Coupled Model Intercomparison Project Phase 5 (CMIP5) to simulate the western Pacific (WP) monsoon is evaluated over four representative regions around Timor, New Guinea, the Solomon Islands and Palau. Coupled model simulations are compared with atmosphere-only model simulations (with observed sea surface temperatures, SSTs) to determine the impact of SST biases on model performance. Overall, the CMIP5 models simulate the WP monsoon better than previous-generation Coupled Model Intercomparison Project Phase 3 (CMIP3) models, but some systematic biases remain. The atmosphere-only models are better able to simulate the seasonal cycle of zonal winds than the coupled models, but display comparable biases in the rainfall. The CMIP5 models are able to capture features of interannual variability in response to the El Niño-Southern Oscillation. In climate projections under the RCP8.5 scenario, monsoon rainfall is increased over most of the WP monsoon domain, while wind changes are small. Widespread rainfall increases at low latitudes in the summer hemisphere appear robust as a large majority of models agree on the sign of the change. There is less agreement on rainfall changes in winter. Interannual variability of monsoon wet season rainfall is increased in a warmer climate, particularly over Palau, Timor and the Solomon Islands. A subset of the models showing greatest skill in the current climate confirms the overall projections, although showing markedly smaller rainfall increases in the western equatorial Pacific. The changes found here may have large impacts on Pacific island countries influenced by the WP monsoon.

MC64-ClustalWP2: A Highly-Parallel Hybrid Strategy to Align Multiple Sequences in Many-Core Architectures

PubMed Central

Díaz, David; Esteban, Francisco J.; Hernández, Pilar; Caballero, Juan Antonio; Guevara, Antonio

2014-01-01

We have developed the MC64-ClustalWP2 as a new implementation of the Clustal W algorithm, integrating a novel parallelization strategy and significantly increasing the performance when aligning long sequences in architectures with many cores. It must be stressed that in such a process, the detailed analysis of both the software and hardware features and peculiarities is of paramount importance to reveal key points to exploit and optimize the full potential of parallelism in many-core CPU systems. The new parallelization approach has focused into the most time-consuming stages of this algorithm. In particular, the so-called progressive alignment has drastically improved the performance, due to a fine-grained approach where the forward and backward loops were unrolled and parallelized. Another key approach has been the implementation of the new algorithm in a hybrid-computing system, integrating both an Intel Xeon multi-core CPU and a Tilera Tile64 many-core card. A comparison with other Clustal W implementations reveals the high-performance of the new algorithm and strategy in many-core CPU architectures, in a scenario where the sequences to align are relatively long (more than 10 kb) and, hence, a many-core GPU hardware cannot be used. Thus, the MC64-ClustalWP2 runs multiple alignments more than 18x than the original Clustal W algorithm, and more than 7x than the best x86 parallel implementation to date, being publicly available through a web service. Besides, these developments have been deployed in cost-effective personal computers and should be useful for life-science researchers, including the identification of identities and differences for mutation/polymorphism analyses, biodiversity and evolutionary studies and for the development of molecular markers for paternity testing, germplasm management and protection, to assist breeding, illegal traffic control, fraud prevention and for the protection of the intellectual property (identification/traceability), including the protected designation of origin, among other applications. PMID:24710354

Action of nitrofurans on E. coli: mutation and induction and repair of daughter-strand gaps in DNA.

PubMed

Lu, C; McCalla, D R; Bryant, D W

1979-06-01

The antibacterial and mutagenic potency of 9 nitrofurans in "treat and plate" experiments varied over almost 5 orders of magnitude. The relative toxicities were as follows: FANFT greater than AF2 greater than ANFT greather than furazolidone greater than furagin greater than nitrofurantoin greater than nitrofurazone greater than methylnitrofuroate greater than nitrofuroic acid. In general, mutagenic activity paralleled toxicity. The compounds at concentrations corresponding to their LD50's, induced mutations at frequencies which ranged from 2.5/10(6) survivors for FANFT to 130/10(6) survivors for furagin (NF416). The observed differences in antibacterial and mutagenic activity are unlikely to be due to lack of activation of the weaker agents since the two most potent agents were reduced somewhat more slowly than many of the less active agents. The relative sensitivities to the antibacterial effects of AF2 of strains WP2, WP2 uvrA, CM561 (lexA) and CM571 (recA) were 1 : 1.6 : 3 : 7 and to nitrofurazone 1 : 1 : 25 : 50. The wvrA strain was 6--7-fold more mutable with both these agents than was WP2. No increase over the spontaneous mutation frequency was observed when recA or lexA strains were exposed to either AF2 or nitrofurazone in these experiments. When wild-type of wvrA bacteria containing nitrofuran-induced lesions replicated their DNA in drug-free medium in the presence of [3H]thymidine for 5 min, the label was found in low molecular weight DNA indicating that daughter-strand gaps were formed. During subsequent incubation in nonradioactive medium the molecular weight of the DNA increased to the control value. A recA strain (which was very sensitive to the lethal effects of AF2 and nitrofurazone) lacked the ability to repair daughter-strand gaps caused by nitrofuran-induced lesions.

Wellness Partners: Design and Evaluation of a Web-Based Physical Activity Diary with Social Gaming Features for Adults

PubMed Central

Wang, Hua; Spruijt-Metz, Donna; Jordan-Marsh, Maryalice; Valente, Thomas William

2013-01-01

Background The United States is currently in an age of obesity and inactivity despite increasing public awareness and scientific knowledge of detrimental long-term health effects of this lifestyle. Behavior-tracking diaries offer an effective strategy for physical activity adherence and weight management. Furthermore, Web-based physical activity diaries can engage meaningful partners in people’s social networks through fun online gaming interactions and generate motivational mechanisms for effective behavioral change and positive health outcomes. Objective Wellness Partners (WP) is a Web-based intervention in the form of a physical activity diary with social networking and game features. Two versions were designed and developed for the purpose of this study—“Diary” only and “Diary+Game”. The objectives of this study included pilot testing the research process of this intervention design, implementation, evaluation, and exploring the effectiveness of social gaming features on adult participants’ physical activity and anthropometric measures. Methods We conducted a field experiment with randomized crossover design. Assessments occurred at baseline, first follow-up (FU, 5-8 weeks after using one version of WP), and second FU (5-8 weeks of using the other version of WP). In the control condition, participants started with the “Diary” version of WP while in the experimental condition, participants started with the “Diary+Game” version of WP. A total of 54 adults (egos) ages 44-88, and their family and friends (alters) ages 17-69 participated in the study in ego-network groups. Both egos and their alters completed online surveys about their exercise habits. In addition, egos completed anthropometric measurements of BMI, fat percentage, and fat mass by bioimpedance. Results From October 2009 to May 2010, flyers, emails, and Web advertisements yielded 335 volunteers who were screened. Rolling recruitment resulted in enrollment of 142 qualified participants in 54 ego-network groups, which were randomly assigned to a study condition. The final analytic sample included 87 individuals from 41 groups. Data were collected from December 2009 to August 2010, and data analysis was completed in 2011. Overall, the participants were given access to the intervention for 10-13 weeks. Statistical analysis suggested an increase in self-reported exercise frequency (mean days per week) from baseline (2.57, SD 1.92) to first FU (3.21, SD 1.74) in both conditions. Stronger effects were seen in the condition where Diary+Game was played first, especially in network groups with larger age variation between the alters and egos. Overall, the decrease in egos’ BMI was statistically significant from baseline to first FU, with greater decrease for those in the Diary+Game first condition (-0.26 vs -0.16 in the Diary first condition). Conclusions The Wellness Partners program increased physical activity among participants and resulted in health benefits among the egos. Web-based diary interventions designed with social gaming features hold potential to promote active lifestyles for middle-age adults and people in their social networks. PMID:23611986

Identification of the Emplacement of Improvised Explosive Devices by Experienced Mission Payload Operators.

PubMed

McNeese, Nathan J; Cooke, Nancy J; Branaghan, Russell; Knobloch, Ashley; Taylor, Amanda

2017-04-01

Improvised Explosive Devices (IEDs) have become one of the deadliest threats to military personnel, resulting in over 50% of American combat casualties in Iraq and Afghanistan. Identification of IED emplacement is conducted by mission payload operators (MPOs). Yet, experienced MPOs are limited in number, making MPO training a critical intervention. In this article, we implement a Cognitive Engineering Based on Expert Skill methodology to better understand how experienced MPOs identify the emplacement of IEDs for the purposes of improving training. First, expert knowledge was elicited through interviews and questionnaires to identify the types of perceptual cues used and how these cues are cognitively processed. Results indicate that there are many different static and dynamic cues that interact with each other over time and space. Using data from the interviews and questionnaires, an empirically grounded framework is presented that explains the cognitive process of IED emplacement detection. Using the overall findings and the framework, IED emplacement training scenarios were developed and built into a simulation. Copyright © 2016 Elsevier Ltd. All rights reserved.

Effect of packaging technology on microbiological and sensory quality of a cooked blood sausage, Morcela de Arroz, from Monchique region of Portugal.

PubMed

Pereira, J A; Dionísio, L; Patarata, L; Matos, T J S

2015-03-01

Morcela de Arroz (MA), a popular Portuguese blood sausage, with high pH and water activity (aw), is traditionally commercialized without preservatives and unpacked. This study evaluated the best packaging solution to extend MA shelf life stored at 4±1°C for 44days: without packaging (WP), vacuum (VP) and modified atmosphere packaging (MAP) (80% CO2; 20% N2). Mesophilic (MTVC), psychrotrophic (PTVC), lactic acid bacteria (LAB), pseudomonads, molds and yeasts, Enterobacteriaceae, Listeria monocytogenes, Salmonella spp., Bacillus cereus, Clostridium perfringens, sensory properties, pH, moisture and aw were studied. Moisture and aw decreased (p<0.05) in WP. pH decreased in WP and MAP during storage. MTVC and PTVC counts increased to values around 7logCFU/g at 44days of storage. LAB and Enterobacteriaceae counts were higher (p<0.05) in VP. Pseudomonads were inhibited (p<0.05) by MAP after 8days of storage. Sensory parameters were affected (p<0.05) by packaging and storage time. Globally, MAP performed better. Copyright © 2014 Elsevier Ltd. All rights reserved.

BWR ASSEMBLY SOURCE TERMS FOR WASTE PACKAGE DESIGN

DOE Office of Scientific and Technical Information (OSTI.GOV)

T.L. Lotz

1997-02-15

This analysis is prepared by the Mined Geologic Disposal System (MGDS) Waste Package Development Department (WPDD) to provide boiling water reactor (BWR) assembly radiation source term data for use during Waste Package (WP) design. The BWR assembly radiation source terms are to be used for evaluation of radiolysis effects at the WP surface, and for personnel shielding requirements during assembly or WP handling operations. The objectives of this evaluation are to generate BWR assembly radiation source terms that bound selected groupings of BWR assemblies, with regard to assembly average burnup and cooling time, which comprise the anticipated MGDS BWR commercialmore » spent nuclear fuel (SNF) waste stream. The source term data is to be provided in a form which can easily be utilized in subsequent shielding/radiation dose calculations. Since these calculations may also be used for Total System Performance Assessment (TSPA), with appropriate justification provided by TSPA, or radionuclide release rate analysis, the grams of each element and additional cooling times out to 25 years will also be calculated and the data included in the output files.« less

Effect of casein to whey protein ratios on the protein interactions and coagulation properties of low-fat yogurt.

PubMed

Zhao, L L; Wang, X L; Tian, Q; Mao, X Y

2016-10-01

In this study, we investigated the effect of casein (CN) to whey protein (WP) ratios (4:1, 3:1, 2:1, and 1:1) on gelation properties and microstructure of low-fat yogurt made with reconstituted skim milk with or without addition of whey protein concentrate. The rheological properties (storage modulus, G'; yield stress; and yield strain) of the obtained low-fat yogurt were greatly enhanced, the fermentation period was shortened, and the microstructure became more compact with smaller pores as the CN:WP ratio decreased. When CN:WP was 2:1 or 1:1, the obtained yogurt coagulum showed higher G' and greater yield stress, with more compact crosslinking and smaller pores. In addition, the more of skim milk powder was replaced by whey protein concentrate, the more disulfide bonds were formed and the greater the occurrence of hydrophobic interactions during heat treatment, which can improve the rheological properties and microstructure of low-fat yogurt. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Mush!

NASA Astrophysics Data System (ADS)

Ashwal, L. D.

2012-12-01

Evidence for emplacement as crystal-laden mushes is abundant in mafic magma systems (i.e. products of broadly basaltic magmatism), including anorthosite complexes, layered mafic intrusions and a variety of sills and dikes. Some of the best examples involve the way feldspar becomes concentrated into anorthositic rocks. Proterozoic anorthosite massifs (e.g. Nain, Rogaland, Adirondacks), whose bulk compositions are characteristically hyperfeldspathic, are best interpreted as resulting from emplacement of plagioclase-rich mushes that ascended to shallow crustal emplacement sites from deep (~Moho) staging chambers in which ~An50 crystals floated due to density relations at high pressure. Supporting evidence includes large (up to ~1 m) grain size, compositional homogeneity of plagioclase with variable Mg# (caused by trapped liquid effects), and protoclastic textures. Isotopic disequilibrium between cumulus plagioclase and post-cumulus pyroxene result from progressive contamination with continental components. This is dramatically demonstrated at Nain (Labrador), where the anorthositic crystal mushes (~1.3 Ga) were emplaced into early Archean (~3.8 Ga) country rocks. High-Al, high-pressure orthopyroxene megacrysts are commonly dragged upward in feldspathic mushes to shallow emplacement sites, where they exsolved plagioclase lamellae (Bybee & Ashwal, this meeting). Archean calcic anorthosites (e.g. Fiskenaesset, W Greenland) and related sills, dikes and flows that contain homogeneous megacrysts up to 10s of cm across of ~An80 also must have formed by mush emplacement, although probably from shallower staging chambers in oceanic rather than continental crust. Many layered mafic intrusions (e.g. Bushveld, Stillwater, Dufek, Duluth) contain thick horizons of anorthosite in which plagioclase compositions are uniform, in some cases throughout >1000 m of stratigraphy. This is best interpreted as representing repeated emplacement of plagioclase-rich mushes from one or more deeper crystallizing magma chambers. In the Bushveld Complex, where deep drill cores have allowed near-continuous measurements of mineral compositions and geophysical properties, the results reveal a subtle cyclicity, invisible in outcrops, over scales of 50 - 100 m, commonly associated with broad reversals in mineral compositional trends. Each of these can be interpreted as a blending zone involving a new addition of crystal-laden magma. Much of Bushveld stratigraphy, and that of other layered intrusions contains plagioclase:pyroxene demonstrably higher than cotectic proportions, supporting overall construction by plagioclase-rich magmas. Isotopic disequilibrium effects, similar to those described above, have been detected in Bushveld cumulates, lending further support to mush emplacement models. Large layered intrusions were probably constructed by repeated emplacement of dozens of individual magmatic entities with variable crystal:melt ratios (Marsh, 2006, Elements). Even the properties of very small (~30 km2) layered intrusions like that at Doros, Namibia (Owen-Smith & Ashwal, this meeting) show abundant evidence for multiple mush emplacement. In plutonic magma bodies arising from mafic magmatism, therefore, the involvement of crystal mushes appears to be the rule rather than the exception.

Design of High Power FELS and the Effects of Diffraction on Detuning in an FEL Oscillator

DTIC Science & Technology

2015-12-01

nx=200, nz =101, nt=50, np=30000, Wp=8, seed=7, wbins=45, ebins=18 ao=10, a=2.6, 0=0, =0, zbins=22 F=0.23, G=0.249, =0.0103, / =0.0617, f=5.83 THEORY: G...y,0) x-4 4 y =1.1 a(x,y,0) 14.5 =1.1 -4 4x -4 4 y Thu Aug 21 14:47:56 2014 nx=200, nz =101, nt=50, np=30000, Wp=8, seed=7, wbins=45, ebins=18 ao=10, a

An Assessment of the Meteorological Conditions Leading to the NOAA WP-3D Engine Compressor Stalls of February 9, 2007, Due to Sea Salt Aerosol Particle Fouling

DTIC Science & Technology

2007-10-25

as this airborne research did. In this particular case, the WP- 3D flight track took it through the dry slot of an occluding storm system which had...just completed a period of explosive cyclogenesis. This particular sector of a storm sometimes experiences very high wind speeds and seas but little...takeoff time of 22:00 Z on February 8 (henceforth referred to as the F8 flight). The incident of February 9 (henceforth F9) was a storm that was part of

[Resistance of earthworms Lumbricus terrestris and Allolobophora turgida to the fungicide captan 50 W.P].

PubMed

Léger, R G; Millette, G J

1977-12-01

Two species of earthworms were kept in Muck, Chicot and Ste-Sophie soils treated with captan 50 W.P. solutions of 700, 1 400 and 2 800 ppm. After a 42-day treatment period, L. terrestris had a 95% survival and A. turgida 100% survival. Using a gas chromatograph method, no captan was detected in tissue extracts of exposed earthworms. Based on the survival rate and the undetected presence of captan in earthworm tissues, we concluded that soil residues of this product are unlikely to be harmful to the animal's ecology.

Cost estimates for flat plate and concentrator collector arrays

NASA Technical Reports Server (NTRS)

Shimada, K.

1982-01-01

The current module and installation costs for the U.S. National Photovoltaic Program's grid-connected systems are significantly higher than required for economic viability of this alternative. Attention is accordingly given to the prospects for installed module cost reductions in flat plate, linear focus Fresnel concentrator, and point focus Fresnel concentrator candidate systems. Cost projections indicate that all three systems would meet near-term and midterm goals, provided that module costs of $2.80/W(p) and $0.70/W(p), respectively, are met. The point focus Fresnel system emerges as the most viable for the near term.

META II: Formal Co-Verification of Correctness of Large-Scale Cyber-Physical Systems During Design (Mod 0006). Volume 2

DTIC Science & Technology

2012-03-01

REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 The public reporting burden for this collection of information is estimated to average 1 hour...currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1 . REPORT DATE (DD-MM-YY) 2. REPORT TYPE 3. DATES COVERED (From...13. SUPPLEMENTARY NOTES Report contains color. PA Case Number: 88ABW-2012-1688; Clearance Date: 23 Mar 2012. See also Volume 1 , AFRL-RZ-WP-TR

Nested granites in question: Contrasted emplacement kinematics of independent magmas in the Zaër pluton, Morocco

NASA Astrophysics Data System (ADS)

Bouchez, Jean Luc; Diot, Herve

1990-10-01

The concentrically zoned Zaër pluton (Variscan Meseta of Morocco), previously modeled as the nesting of two magmas forming a ballooning pluton, is here subjected to a study of its internal magmatic and solid-state structures. The magmatic flow patterns, derived mainly from anisotropy of magnetic susceptibility measurements, together with structural observations down to thin-section scale, indicate that these two magmas have undergone totally independent kinematics of emplacement. This supports recent isotope geochemistry and geochronology data indicating independent origin of the magmas and diachronism of emplacement, respectively. Thus, we propose that a magma diapir, probably emplaced within a crustal fracture zone, cooled down to brittle conditions, before a likely flat-lying fracture was opened within the fracture zone and was filled with a new and compositionally different pulse of magma.

Deformation of the Wineglass Welded Tuff and the timing of caldera collapse at Crater Lake, Oregon

USGS Publications Warehouse

Kamata, H.; Suzuki-Kamata, K.; Bacon, C.R.

1993-01-01

Four types of deformation occur in the Wineglass Welded Tuff on the northeast caldera rim of Crater Lake: (a) vertical tension fractures; (b) ooze-outs of fiamme: (c) squeeze-outs of fiamme; and (d) horizontal pull-apart structures. The three types of plastic deformation (b-d) developed in the lower part of the Wineglass Welded Tuff where degree of welding and density are maximum. Deformation originated from concentric normal faulting and landsliding as the caldera collapsed. The degree of deformation of the Wineglass Welded Tuff increases toward the northeast part of the caldera, where plastic deformation occurred more easily because of a higher emplacement temperature probably due to proximity to the vent. The probable glass transition temperature of the Wineglass Welded Tuff suggests that its emplacement temperature was ???750??C where the tuff is densely welded. Calculation of the conductive cooling history of the Wineglass Welded Tuff and the preclimactic Cleetwood (lava) flow under assumptions of a initially isothermal sheet and uniform properties suggests that (a) caldera collapse occurred a maximum of 9 days after emplacement of the Wineglass Welded Tuff, and that (b) the period between effusion of the Cleetwood (lava) flow and onset of the climactic eruption was <100 years. If cooling is controlled more by precipitation during quiescent periods than by conduction, these intervals must be shorter than the calculated times. ?? 1993.

The ultimate fate of a synmagmatic shear zone. Interplay between rupturing and ductile flow in a cooling granite pluton

NASA Astrophysics Data System (ADS)

Zibra, I.; White, J. C.; Menegon, L.; Dering, G.; Gessner, K.

2018-05-01

The Neoarchean Cundimurra Pluton (Yilgarn Craton, Western Australia) was emplaced incrementally along the transpressional Cundimurra Shear Zone. During syndeformational cooling, discrete networks of cataclasites and ultramylonites developed in the narrowest segment of the shear zone, showing the same kinematics as the earlier synmagmatic structures. Lithological boundaries between aplite/pegmatite veins and host granitic gneiss show more intense pre-cataclasite fabrics than homogeneous material, and these boundaries later became the preferred sites of shear rupture and cataclasite nucleation. Transient ductile instabilities established along lithological boundaries culminated in shear rupture at relatively high temperature (∼500-600 °C). Here, tensile fractures at high angles from the fault plane formed asymmetrically on one side of the fault, indicating development during seismic rupture, establishing the oldest documented earthquake on Earth. Tourmaline veins were emplaced during brittle shearing, but fluid pressure probably played a minor role in brittle failure, as cataclasites are in places tourmaline-free. Subsequent ductile deformation localized in the rheologically weak tourmaline-rich aggregates, forming ultramylonites that deformed by grain-size sensitive creep. The shape and width of the pluton/shear zone and the regime of strain partitioning, induced by melt-present deformation and established during pluton emplacement, played a key role in controlling the local distribution of brittle and then ductile subsolidus structures.

Contrasting magmatic structures between small plutons and batholiths emplaced at shallow crustal level (Sierras de Córdoba, Argentina)

NASA Astrophysics Data System (ADS)

Pinotti, Lucio P.; D'Eramo, Fernando J.; Weinberg, Roberto F.; Demartis, Manuel; Tubía, José María; Coniglio, Jorge E.; Radice, Stefania; Maffini, M. Natalia; Aragón, Eugenio

2016-11-01

Processes like injection, magma flow and differentiation and influence of the regional strain field are here described and contrasted to shed light on their role in the formation of small plutons and large batholiths their magmatic structures. The final geometric and compositional arrangement of magma bodies are a complex record of their construction and internal flow history. Magma injection, flow and differentiation, as well as regional stresses, all control the internal nature of magma bodies. Large magma bodies emplaced at shallow crustal levels result from the intrusion of multiple magma batches that interact in a variety of ways, depending on internal and external dynamics, and where the early magmatic, growth-related structures are commonly overprinted by subsequent history. In contrast, small plutons emplaced in the brittle-ductile transition more likely preserve growth-related structures, having a relatively simple cooling history and limited internal magma flow. Outcrop-scale magmatic structures in both cases record a rich set of complementary information that can help elucidate their evolution. Large and small granitic bodies of the Sierra Pampeanas preserve excellent exposures of magmatic structures that formed as magmas stepped through different rheological states during pluton growth and solidification. These structures reveal not only the flow pattern inside magma chambers, but also the rheological evolution of magmas in response to temperature evolution.

Paving the seafloor: Volcanic emplacement processes during the 2005-2006 eruptions at the fast spreading East Pacific Rise, 9°50‧N

NASA Astrophysics Data System (ADS)

Fundis, A. T.; Soule, S. A.; Fornari, D. J.; Perfit, M. R.

2010-08-01

The 2005-2006 eruptions near 9°50'N at the East Pacific Rise (EPR) marked the first observed repeat eruption at a mid-ocean ridge and provided a unique opportunity to deduce the emplacement dynamics of submarine lava flows. Since these new flows were documented in April 2006, a total of 40 deep-towed imaging surveys have been conducted with the Woods Hole Oceanographic Institution's (WHOI) TowCam system. More than 60,000 digital color images and high-resolution bathymetric profiles of the 2005-2006 flows from the TowCam surveys were analyzed for lava flow morphology and for the presence of kipukas, collapse features, faults and fissures. We use these data to quantify the spatial distributions of lava flow surface morphologies and to investigate how they relate to the physical characteristics of the ridge crest, such as seafloor slope, and inferred dynamics of flow emplacement. We conclude that lava effusion rate was the dominant factor controlling the observed morphological variations in the 2005-2006 flows. We also show that effusion rates were higher than in previously studied eruptions at this site and varied systematically along the length of the eruptive fissure. This is the first well-documented study in which variations in seafloor lava morphology can be directly related to a well documented ridge-crest eruption where effusion rate varied significantly.

Unique Epstein-Barr virus (EBV) latent gene expression, EBNA promoter usage and EBNA promoter methylation status in chronic active EBV infection.

PubMed

Yoshioka, Mikio; Kikuta, Hideaki; Ishiguro, Nobuhisa; Ma, Xiaoming; Kobayashi, Kunihiko

2003-05-01

Chronic active Epstein-Barr virus infection (CAEBV) has been considered to be a non-neoplastic T-cell lymphoproliferative disease associated with Epstein-Barr virus (EBV) infection. In EBV-associated diseases, the cell phenotype-dependent differences in EBV latent gene expression may reflect the strategy of the virus in relation to latent infection. We previously reported that EBV latent gene expression was restricted; EBV nuclear antigen 1 (EBNA1) transcripts were consistently detected in all spleen samples from five CAEBV patients, but EBNA2 transcripts were detected in only one sample. EBV latent gene expression is controlled by distinct usage of three EBNA promoters (Cp, Wp and Qp). In this study, we examined the EBNA promoter usage by RT-PCR and the methylation status in the Cp and Wp regions using bisulfite PCR analysis in spleen samples from CAEBV patients. EBNA1 transcripts were unexpectedly initiated not from Qp but from Cp in all samples in spite of the restricted form of latency. Furthermore, while Cp was active, Cp was heavily methylated, indicating that CAEBV has unique EBV latent gene expression, EBNA promoter usage and EBNA promoter methylation status, in part due to unique splicing of Cp-initiated transcripts and an activation mechanism in hypermethylated Cp.

Do Different Types of School Mathematics Development Depend on Different Constellations of Numerical versus General Cognitive Abilities?

PubMed Central

Fuchs, Lynn S.; Geary, David C.; Compton, Donald L.; Fuchs, Douglas; Hamlett, Carol L.; Seethaler, Pamela M.; Bryant, Joan D.; Schatschneider, Christopher

2010-01-01

The purpose of this study was to examine the interplay between basic numerical cognition and domain-general abilities (such as working memory) in explaining school mathematics learning. First graders (n=280; 5.77 years) were assessed on 2 types of basic numerical cognition, 8 domain-general abilities, procedural calculations (PCs), and word problems (WPs) in fall and then reassessed on PCs and WPs in spring. Development was indexed via latent change scores, and the interplay between numerical and domain-general abilities was analyzed via multiple regression. Results suggest that the development of different types of formal school mathematics depends on different constellations of numerical versus general cognitive abilities. When controlling for 8 domain-general abilities, both aspects of basic numerical cognition were uniquely predictive of PC and WP development. Yet, for PC development, the additional amount of variance explained by the set of domain-general abilities was not significant, and only counting span was uniquely predictive. By contrast, for WP development, the set of domain- general abilities did provide additional explanatory value, accounting for about the same amount of variance as the basic numerical cognition variables. Language, attentive behavior, nonverbal problem solving, and listening span were uniquely predictive. PMID:20822213

The under-representation of minority ethnic groups in UK medical research.

PubMed

Smart, Andrew; Harrison, Eric

2017-02-01

Objectives . The paper investigates differences in engagement with medical research between White British and Black, Asian and Minority Ethnic (BAME) groups in the UK, using data from the Wellcome Trust Monitor (WTM). The study used two waves of the WTM (n = 2575) to examine associations between ethnic group and participation in medical research, and willingness to participate (WP) in medical research. Logistic regression models controlled for socio-economic and demographic factors, and relevant outlooks and experiences that are assumed to be markers of engagement. Respondents from the BAME group were less likely to have participated in medical research compared to those from the White British group, but there was only patchy evidence of small ethnic group differences in WP. Influences on engagement with medical research varied somewhat between the White British and BAME groups, in particular in relation to occupation, education, health, attitudes to medical science and belief. These findings consolidate previously context-specific evidence of BAME group under-representation in the UK, and highlight heterogeneity in that group. Efforts to address the under-representation of those from BAME groups might benefit from targeted strategies for recruitment and advocacy, although improved data sets are required to fully understand ethnic differences in engagement with medical research.

Understanding the mechanical coupling between magma emplacement and the resulting deformation: the example of saucer-shaped sills

NASA Astrophysics Data System (ADS)

Galland, O.; Neumann, E. R.; Planke, S.

2009-12-01

The mechanical coupling between magma intrusions and the surrounding rocks plays a major role in the emplacement of volcanic plumbing systems. The deformation associated with magma emplacement has been widely studied, such as caldera inflation/deflation, volcano deformation during dike intrusion, and doming above laccoliths. However, the feedback processes, i.e. the effect of deformation resulting from intruding magma on the propagation of the intrusion itself, have rarely been studied. Saucer-shaped sills are adequate geological objects to understand such processes. Indeed, observation show that saucer-shaped sills are often associated with dome-like structures affecting the overlying sediments. In addition, there is a clear geometrical relation between the sills and the domes: the dome diameters are almost identical to those of saucers, and the tips of the inclined sheets of saucers are superimposed on the edges of the domes. In this presentation, we report on experimental investigations of the emplacement mechanisms of saucer-shaped sills and associated deformation. The model materials were (1) cohesive fine-grained silica flour, representing brittle crust, and (2) molten low-viscosity oil, representing magma. A weak layer located at the top of the injection inlet simulates strata. The main variable parameter is injection depth. During experiments, the surface of the model is digitalized through a structured light technique based on the moiré projection principle. Such a tool provides topographic maps of the surface of the model and allows a periodic (every 1.5 s) monitoring of the model topography. When the model magma starts intruding, a symmetrical dome rises above the inlet. Subsequently, the dome inflates and widens, and then evolves to a plateau-like feature, with nearly flat upper surface and steep sides. At the end of the experiments, the intruding liquid erupts at the edge of the plateau. The intrusions formed in the experiments are saucer-shaped sills, with flat inner sills, steep inclined sheets and flatter outer sills. Like in nature, there are clear relations between the intrusions geometries and the domes: (1) the inclined sheet formed underneath the edge of the plateau, and the oil erupts at its outermost edge; (2) the diameter of the sill is similar to that of the dome. In addition, the diameter of the sills and the domes increased with increasing injection depth. Our results suggest that the evolution of the deforming surface reflects the evolution of the intrusion, i.e. the first doming phase corresponds to the emplacement of a horizontal basal sill, and the dome-to-plateau transition corresponds to the transition from a basal sill to an inclined sheet. Conversely, the correlation between the dome and intrusion width and emplacement depth suggests that the development of the doming exerts a feedback on the sill propagation and controls the formation of the inclined sheets. Thus, our study shows that a good understanding of the coupling between magma emplacement and the associated deformation has major implications for the understanding of magma transport in volcanic systems.

A Volume Flux Approach to Cryolava Dome Emplacement on Europa

NASA Technical Reports Server (NTRS)

Quick, Lynnae C.; Fagents, Sarah A.; Hurford, Terry A.; Prockter, Louise M.

2017-01-01

We previously modeled a subset of domes on Europa with morphologies consistent with emplacement by viscous extrusions of cryolava. These models assumed instantaneous emplacement of a fixed volume of fluid onto the surface, followed by relaxation to form domes. However, this approach only allowed for the investigation of late-stage eruptive processes far from the vent and provided little insight into how cryolavas arrived at the surface. Consideration of dome emplacement as cryolavas erupt at the surface is therefore pertinent. A volume flux approach, in which lava erupts from the vent at a constant rate, was successfully applied to the formation of steep-sided volcanic domes on Venus. These domes are believed to have formed in the same manner as candi-date cryolava domes on Europa. In order to gain a more complete understanding of the potential for the emplacement of Europa domes via extrusive volcanism, we have applied this new volume flux approach to the formation of putative cryovolcanic domes on Europa. Assuming as in that europan cryolavas are briny, aqueous solutions which may or may not contain some ice crystal fraction, we present the results of this modeling and explore theories for the formation of low-albedo moats that surround some domes.

Analogue experiments as benchmarks for models of lava flow emplacement

NASA Astrophysics Data System (ADS)

Garel, F.; Kaminski, E. C.; Tait, S.; Limare, A.

2013-12-01

During an effusive volcanic eruption, the crisis management is mainly based on the prediction of lava flow advance and its velocity. The spreading of a lava flow, seen as a gravity current, depends on its "effective rheology" and on the effusion rate. Fast-computing models have arisen in the past decade in order to predict in near real time lava flow path and rate of advance. This type of model, crucial to mitigate volcanic hazards and organize potential evacuation, has been mainly compared a posteriori to real cases of emplaced lava flows. The input parameters of such simulations applied to natural eruptions, especially effusion rate and topography, are often not known precisely, and are difficult to evaluate after the eruption. It is therefore not straightforward to identify the causes of discrepancies between model outputs and observed lava emplacement, whereas the comparison of models with controlled laboratory experiments appears easier. The challenge for numerical simulations of lava flow emplacement is to model the simultaneous advance and thermal structure of viscous lava flows. To provide original constraints later to be used in benchmark numerical simulations, we have performed lab-scale experiments investigating the cooling of isoviscous gravity currents. The simplest experimental set-up is as follows: silicone oil, whose viscosity, around 5 Pa.s, varies less than a factor of 2 in the temperature range studied, is injected from a point source onto a horizontal plate and spreads axisymmetrically. The oil is injected hot, and progressively cools down to ambient temperature away from the source. Once the flow is developed, it presents a stationary radial thermal structure whose characteristics depend on the input flow rate. In addition to the experimental observations, we have developed in Garel et al., JGR, 2012 a theoretical model confirming the relationship between supply rate, flow advance and stationary surface thermal structure. We also provide experimental observations of the effect of wind the surface thermal structure of a viscous flow, that could be used to benchmark a thermal heat loss model. We will also briefly present more complex analogue experiments using wax material. These experiments present discontinuous advance behavior, and a dual surface thermal structure with low (solidified) vs. high (hot liquid exposed at the surface) surface temperatures regions. Emplacement models should tend to reproduce these two features, also observed on lava flows, to better predict the hazard of lava inundation.

Mass wasting features in Juventae Chasma, Mars

NASA Astrophysics Data System (ADS)

Sarkar, Ranjan; Singh, Pragya; Porwal, Alok; Ganesh, Indujaa

2016-07-01

Introduction : We report mass-wasting features preserved as debris aprons from Juventae Chasma. Diverse lines of evidence and associated geomorphological features indicate that fluidized ice or water within the wall rocks of the chasma could be responsible for mobilizing the debris. Description : The distinctive features of the landslides in Juvenate Chasma are: (1) lack of a well-defined crown or a clear-cut section at their point of origin and instead the presence of amphitheatre-headed tributary canyons; (2) absence of slump blocks; (3) overlapping of debris aprons; (4) a variety of surface textures from fresh and grooved to degraded and chaotic; (5) rounded lobes of debris aprons; (6) large variation of sizes from small lumps (~0.52 m2) to large tongue shaped ones (~ 80 m2); (7) smaller average size of landslides as compared to other chasmas; and (8) occasional preservation of fresh surficial features indicating recent emplacement. Discussion : Amphitheatre-headed tributary canyons, which are formed due to ground water sapping, indicate that the same was responsible for wall-section collapse, although a structural control cannot be completely ruled out. The emplacement of the mass wasting features preferentially at the mouths of amphitheatre-headed tributary canyons along with the rounded flow fronts of the debris suggest fluids may have played a vital role in their emplacement. The mass-wasting features in Juventae Chasma are unique compared to other landslides in Valles Marineris despite commonalities such as the radial furrows, fan-shaped outlines, overlapping aprons and overtopped obstacles. The unique set of features and close association with amphitheatre-headed tributary canyons imply that the trigger of the landslides was not structural or tectonic but possibly weakness imparted by the presence of water or ice in the pore-spaces of the wall. Craters with fluidized ejecta blankets and scalloped depressions in the surrounding plateau also support this possibility. Depending on the amounts of fluids involved at the time of emplacement, these mass movements may also qualify as debris flows. The role of fluids in the Valles Marineris landslides is still debated; however, in the Juventae Chasma landslides we see unique features which set these apart from other landslides in Valles Marineris. Further study is required to fully investigate the mechanism of emplacement of these debris.

Detection of occult hepatitis B and window period infection among blood donors by individual donation nucleic acid testing in a tertiary care center in South India.

PubMed

Keechilot, Cinzia S; Shenoy, Veena; Kumar, Anil; Biswas, Lalitha; Vijayrajratnam, Sukhithasri; Dinesh, Kavitha; Nair, Prem

With the introduction of highly sensitive hepatitis B surface antigen immunoassay, transfusion associated HBV infection have reduced drastically but they still tend to occur due to blood donors with occult hepatitis B infection (OBI) and window period (WP) infection. Sera from, 24338 healthy voluntary blood donors were screened for HBsAg, HIV and HCV antibody using Vitros Enhanced Chemiluminescent Immunoassay. The median age of the donor population was 30 (range 18-54) with male preponderance (98%). All serologically negative samples were screened by nucleic acid testing (NAT) for viral DNA and RNA. NAT-positive samples were subjected to discriminatory NAT for HBV, HCV, and HIV and all samples positive for HBV DNA were tested for anti-HBc, anti-HBs, HBeAg. Viral load was determined using artus HBV RG PCR Kit. Of the 24,338 donors screened, 99.81% (24292/24338) were HBsAg negative of which NAT was positive for HBV DNA in 0.0205% (5/24292) donors. Four NAT positive donors had viral load of <200 IU/ml making them true cases of OBI. One NAT positive donor was negative for all antibodies making it a case of WP infection. Among OBI donors, 75% (3/4) were immune and all were negative for HBeAg. Precise HBV viral load could not be determined in all (5/5) NAT positive donors due to viral loads below the detection limit of the artus HBV RG PCR Kit. The overall incidence of OBI and WP infections was found to be low at 1 in 6503 and 1 in 24214 donations, respectively. More studies are needed to determine the actual burden of WP infections in Indian blood donors.

Monitoring of a 1 kWp Solar Photovoltaic System

NASA Astrophysics Data System (ADS)

Malek, M. F.; Zainuddin, H.; Rejab, S. N. M.; Shaari, S. N.; Shaari, S.; Omar, A. M.; Rusop, M.

2009-06-01

A 1 kWp `stand alone' PV system consists of 4 module (2 BP SX75U module and 2 BP 275F module), inverter, 2 thermocouple, 3 voltage sensor, 3 current sensor, 4 battery and data logger (Data Taker DT80) has been set up. This research involve nine parameters which are irradiance (Ia), ambient temperature (Tamb), module temperature (Tmod), module voltage (Vmod), battery voltage (Vbat), load voltage (Vload), module current (Imod), battery current (Ibat) and load current (Iload). All parameters were measured using the equipments and sensors that connected directly to data logger (Data Taker DT80) to interpret and show the data on computer using the Delogger sofware. The data then was transferred into the computer and analyzed using the Deview and Microsoft Excel software to determine the performance indices for the stand alone PV system. From the analysis a few performance indices were determined. The range of daily solar irradiation is between 2.20 kWhm-2 to 4.00 kWhm-2, while the range of total global irradiation is between 5.76 kWh to 10.48 kWh. For daily total energy yield, the range is between 0.23 kWh d-1 to 0.28 kWh d-1. The range for clearness index is between 0.49% to 0.89%. The range for final yield is between 0.77 kWh d-1 kWp-1 to 0.93 kWhd-1 kWp-1 while the range of array efficiency is between 2.53% to 4.65%. Lastly, the range of the performance ratio is between 22.08% to 40.58%.

Protective effect of basil (Ocimum basilicum L.) against oxidative DNA damage and mutagenesis.

PubMed

Berić, Tanja; Nikolić, Biljana; Stanojević, Jasna; Vuković-Gacić, Branka; Knezević-Vukcević, Jelena

2008-02-01

Mutagenic and antimutagenic properties of essential oil (EO) of basil and its major constituent Linalool, reported to possess antioxidative properties, were examined in microbial tests. In Salmonella/microsome and Escherichia. coli WP2 reversion assays both derivatives (0.25-2.0 microl/plate) showed no mutagenic effect. Salmonella. typhimurium TA98, TA100 and TA102 strains displayed similar sensitivity to both basil derivatives as non-permeable E. coli WP2 strains IC185 and IC202 oxyR. Moreover, the toxicity of basil derivatives to WP2 strains did not depend on OxyR function. The reduction of t-BOOH-induced mutagenesis by EO and Linalool (30-60%) was obtained in repair proficient strains of the E. coli K12 assay (Nikolić, B., Stanojević, J., Mitić, D., Vuković-Gacić, B., Knezević-Vukcević, J., Simić, D., 2004. Comparative study of the antimutagenic potential of vitamin E in different E. coli strains. Mutat. Res. 564, 31-38), as well as in E. coli WP2 IC202 strain. EO and Linalool reduced spontaneous mutagenesis in mismatch repair deficient E. coli K12 strains (27-44%). In all tests, antimutagenic effect of basil derivatives was comparable with that obtained with model antioxidant vitamin E. Linalool and vitamin E induced DNA strand breaks in Comet assay on S. cerevisiae 3A cells, but at non-genotoxic concentrations (0.075 and 0.025 microg/ml, respectively) they reduced the number of H(2)O(2)-induced comets (45-70% Linalool and 80-93% vitamin E). Obtained results indicate that antigenotoxic potential of basil derivatives could be attributed to their antioxidative properties.

Direct enzyme assay evidence confirms aldehyde reductase function of Ydr541cp and Ygl039wp from Saccharomyces cerevisiae.

PubMed

Moon, Jaewoong; Liu, Z Lewis

2015-04-01

The aldehyde reductase gene ARI1 is a recently characterized member of an intermediate subfamily within the short-chain dehydrogenase/reductase (SDR) superfamily that clarified mechanisms of in situ detoxification of 2-furaldehyde and 5-hydroxymethyl-2-furaldehyde by Saccharomyces cerevisiae. Uncharacterized open reading frames (ORFs) are common among tolerant candidate genes identified for lignocellulose-to-advanced biofuels conversion. This study presents partially purified proteins of two ORFs, YDR541C and YGL039W, and direct enzyme assay evidence against aldehyde-inhibitory compounds commonly encountered during lignocellulosic biomass fermentation processes. Each of the partially purified proteins encoded by these ORFs showed a molecular mass of approximately 38 kDa, similar to Ari1p, a protein encoded by aldehyde reductase gene. Both proteins demonstrated strong aldehyde reduction activities toward 14 aldehyde substrates, with high levels of reduction activity for Ydr541cp toward both aromatic and aliphatic aldehydes. While Ydr541cp was observed to have a significantly higher specific enzyme activity at 20 U/mg using co-factor NADPH, Ygl039wp displayed a NADH preference at 25 U/mg in reduction of butylaldehyde. Amino acid sequence analysis identified a characteristic catalytic triad, Ser, Tyr and Lys; a conserved catalytic motif of Tyr-X-X-X-Lys; and a cofactor-binding sequence motif, Gly-X-X-Gly-X-X-Ala, near the N-terminus that are shared by Ydr541cp, Ygl039wp, Yol151wp/GRE2 and Ari1p. Findings of aldehyde reductase genes contribute to the yeast gene annotation and aids development of the next-generation biocatalyst for advanced biofuels production. Copyright © 2015 John Wiley & Sons, Ltd.

Water consumption increases weight loss during a hypocaloric diet intervention in middle-aged and older adults.

PubMed

Dennis, Elizabeth A; Dengo, Ana Laura; Comber, Dana L; Flack, Kyle D; Savla, Jyoti; Davy, Kevin P; Davy, Brenda M

2010-02-01

Water consumption acutely reduces meal energy intake (EI) among middle-aged and older adults. Our objectives were to determine if premeal water consumption facilitates weight loss among overweight/obese middle-aged and older adults, and to determine if the ability of premeal water consumption to reduce meal EI is sustained after a 12-week period of increased water consumption. Adults (n = 48; 55-75 years, BMI 25-40 kg/m(2)) were assigned to one of two groups: (i) hypocaloric diet + 500 ml water prior to each daily meal (water group), or (ii) hypocaloric diet alone (nonwater group). At baseline and week 12, each participant underwent two ad libitum test meals: (i) no preload (NP), and (ii) 500 ml water preload (WP). Meal EI was assessed at each test meal and body weight was assessed weekly for 12 weeks. Weight loss was ~2 kg greater in the water group than in the nonwater group, and the water group (beta = -0.87, P < 0.001) showed a 44% greater decline in weight over the 12 weeks than the nonwater group (beta = -0.60, P < 0.001). Test meal EI was lower in the WP than NP condition at baseline, but not at week 12 (baseline: WP 498 +/- 25 kcal, NP 541 +/- 27 kcal, P = 0.009; 12-week: WP 480 +/- 25 kcal, NP 506 +/- 25 kcal, P = 0.069). Thus, when combined with a hypocaloric diet, consuming 500 ml water prior to each main meal leads to greater weight loss than a hypocaloric diet alone in middle-aged and older adults. This may be due in part to an acute reduction in meal EI following water ingestion.

Water Consumption Increases Weight Loss During a Hypocaloric Diet Intervention in Middle-aged and Older adults

PubMed Central

Dennis, Elizabeth A.; Dengo, Ana Laura; Comber, Dana L.; Flack, Kyle D.; Savla, Jyoti; Davy, Kevin P.; Davy, Brenda M.

2010-01-01

Water consumption acutely reduces meal energy intake (EI) among middle-aged and older adults. Our objectives were to determine if premeal water consumption facilitates weight loss among overweight/obese middle-aged and older adults, and to determine if the ability of premeal water consumption to reduce meal EI is sustained after a 12-week period of increased water consumption. Adults (n = 48; 55–75 years, BMI 25–40 kg/m2) were assigned to one of two groups: (i) hypocaloric diet + 500 ml water prior to each daily meal (water group), or (ii) hypocaloric diet alone (nonwater group). At baseline and week 12, each participant underwent two ad libitum test meals: (i) no preload (NP), and (ii) 500 ml water preload (WP). Meal EI was assessed at each test meal and body weight was assessed weekly for 12 weeks. Weight loss was ~2 kg greater in the water group than in the nonwater group, and the water group (β = −0.87, P < 0.001) showed a 44% greater decline in weight over the 12 weeks than the nonwater group (β = −0.60, P < 0.001). Test meal EI was lower in the WP than NP condition at baseline, but not at week 12 (baseline: WP 498 ± 25 kcal, NP 541 ± 27 kcal, P = 0.009; 12-week: WP 480 ± 25 kcal, NP 506 ± 25 kcal, P = 0.069). Thus, when combined with a hypocaloric diet, consuming 500 ml water prior to each main meal leads to greater weight loss than a hypocaloric diet alone in middle-aged and older adults. This may be due in part to an acute reduction in meal EI following water ingestion. PMID:19661958

Coyote unmanned aircraft system observations in Hurricane Edouard (2014)

NASA Astrophysics Data System (ADS)

Cione, J. J.; Kalina, E. A.; Uhlhorn, E. W.; Farber, A. M.; Damiano, B.

2016-09-01

Horizontal wind, temperature, and moisture observations are presented from two Coyote unmanned aircraft system (UAS) flights in the boundary layer of Hurricane Edouard (2014). The first flight sampled the meteorological conditions in the eye and eyewall at altitudes from 900 to 1500 m while Edouard was a major hurricane (105 kt) on 16 September 2014. The following day, a second Coyote sampled the inflow layer outside of the storm core at 760 m altitude, when Edouard had weakened to an 80-kt hurricane. These flights represent the first deployments of a UAS from an airborne manned aircraft into a tropical cyclone. Comparisons between the Coyote data and the Lockheed WP-3D Orion (WP-3D) flight-level measurements and analyses constructed from dropsonde data are also provided. On 16 September 2014, the Coyote-measured horizontal wind speeds agree, on average, to within 1 m s-1 of the wind speeds observed by the WP-3D and reproduce the shape of the radial wind profile from the WP-3D measurements. For the inflow layer experiment on 17 September, the mean wind speeds from the Coyote and the dropsonde analysis differ by only 0.5 m s-1, while the Coyote captured increased variability (σ = 3.4 m s-1) in the horizontal wind field compared to the dropsonde analysis (σ = 2.2 m s-1). Thermodynamic data from the Coyote and dropsondes agree well for both flights, with average discrepancies of 0.4°C and 0.0°C for temperature and 0.7°C and 1.3°C for dew point temperature on 16 and 17 September, respectively

Options for using Landsat and RapidEye satellite images aiming the water productivity assessments in mixed agro-ecosystems

NASA Astrophysics Data System (ADS)

de C. Teixeira, Antônio H.; Leivas, Janice F.; Bayma-Silva, Gustavo

2016-10-01

For water productivity (WP) assessments, the SAFER (Surface Algorithm for Evapotranspiration Retrieving) algorithm for evapotranspiration (ET) and the Monteith's light use efficiency (LUE) model for biomass production (BIO), were applied to Landsat and RapidEye satellite images, in the Brazilian semiarid region, inside the dry season of 2011, in a mixture of irrigated and rainfed agro-ecosystems. Firstly, with the Landsat image, the methodology from which the surface temperature (T0) is derived as a residue in the radiation balance was tested. Low differences were detected, being Landsat ET with the thermal band averaged 0.9 +/- 1.5 mm d-1, while without it the mean value was 0.8 +/- 1.5 mm d-1. The corresponding Landsat BIO values were respectively 28 +/- 59 and 28 +/- 58 kg ha-1 d-1, resulting in mean WP of 1.3 +/- 1.3 kg m-3, in both cases. After having confidence on the residual methodology for retrieving T0 it was applied to the RapidEye image, resulting in average pixel values for ET, BIO and WP of 0.6 +/- 1.5 mm d-1, 26 +/- 58 kg ha-1 d-1 and 0.9 +/- 1.3 kg m-3, representing 75%, 93% and 69% of the Landsat ones obtained without the thermal band. In addition, the Surface Resistance Algorithm (SUREAL) was used to classify the agro-ecosystems into irrigated crops and natural vegetation by using the RapidEye image. The incremental values for ET, BIO and WP in 2011 were 2.0 +/- 1.3 mm d-1, 88 +/- 87 kg ha d-1 and 2.5 +/- 0.6 kg m-3, respectively, as a result of the replacement of the natural species by crops.

Water productivity of different land uses in watersheds assessed from satellite imagery Landsat 5 Thematic Mapper

NASA Astrophysics Data System (ADS)

Franco, Renato A. M.; Hernandez, Fernando B. T.; Teixeira, Antonio H. C.

2014-10-01

Water productivity (WP) of various classes of soil usage from watersheds was estimated using the SAFER - Simple Algorithm For Evapotranspiration Retrieving - algorithm and the Monteith equation to estimate the parameters of biomass production (BIO). Monteith's equation is used to quantify the absorbed photosynthetically active radiation (APAR) and Actual Evapotranspiration (ET) was estimated with the SAFER algorithm. The objective of the research is to analyze the spatial-temporal water productivity in watersheds with different uses and soil occupation during the period from 1996 to 2010, in conditions of drought and using the Monteith model to estimate the production of BIO and using the SAFER model for ET. Results indicated an increase of 153.2% in ET value during the period 1997-2010, showing that the irrigated areas were responsible for this increase in ET values. In September 2000, image of day of year (DOY) 210 showed high values of BIO, with averages of 80.67 kg ha-1d-1. In the year 2010 (DOY:177), the mean value of BIO was 62.90 kg ha-1d-1, with an irrigated area with a maximum value of 227.5 kg ha-1d-1. The highest incremental values of BIO is verified from the start of irrigated areas equal to the value of ET, because there is a relationship between BIO and ET. The maximum water productivity (WP) value occurred in June/2001, with 3,08 kg m-3, the second highest value was in 2010 (DOY:177), with a value of 2,97 kg m-3. Irrigated agriculture show the highest WP value, with maximum value of 6.7 kg m-3. The lowest WP was obtained for DOY 267, because of the dry season with condition of low soil moisture.

Comparison of water and air charged transducer catheter pressures in the evaluation of cystometrogram and voiding pressure studies.

PubMed

McKinney, Timothy B; Babin, Elizabeth A; Ciolfi, Veronica; McKinney, Cynthia R; Shah, Nima

2018-04-01

Air-charged (AC) and water-perfused (WP) catheters have been evaluated for differences in measuring pressures for voiding dysfunction. Typically, a two-catheter system was used. We believe that simultaneous pressure measurements with AC and WP in a single catheter will provide analogous pressures for coughs, Valsalvas, and maximum pressures in voiding pressure studies (VPS). This IRB approved prospective study included 50 women over age 21. AC dual TDOC catheters were utilized. The water-filling channel served as the bladder filler and the water pressure readings. Patients were evaluated with empty bladders and at volumes of 50-100 mL, 200 mL, and maximum capacity with cough and Valsalva maneuvers. Comparative analysis was performed on maximum stress peak pressures. At maximum bladder capacity, VPS was done and maximum voiding pressure was recorded. Comparing coughs and Valsalva maneuvers pressures, there was significant increase in variability between AC and WP measurements with less than 50 mL volume (P < 0.001). Significant correlations were observed between AC and WP measurements for coughs and Valsalvas with bladder volume over 50 mL. Visual impression showed virtually identical tracings. Cough measurements had an average difference of 0.25 cmH 2 O (±8.81) and Valsalva measurements had an average difference of 3.15 cmH 2 O (±4.72). Thirty-eight women had usable maximum voiding pressure measurements and had a strong correlation. Cystometrogram and maximum voiding pressure measurements done with either water or air charged catheters will yield similarly accurate results and are comparable. Results suggest more variability at low bladder volumes <50 mL. © 2018 Wiley Periodicals, Inc.

Whey protein with potassium bicarbonate supplement attenuates the reduction in muscle oxidative capacity during 19 days of bed rest.

PubMed

Bosutti, Alessandra; Salanova, Michele; Blottner, Dieter; Buehlmeier, Judith; Mulder, Edwin; Rittweger, Jörn; Yap, Moi Hoon; Ganse, Bergita; Degens, Hans

2016-10-01

The effectiveness of whey protein plus potassium bicarbonate-enriched diet (WP+KHCO 3 ) in mitigating disuse-induced changes in muscle fiber oxidative capacity and capillarization was investigated in a 21-day crossover design bed rest study. Ten healthy men (31 ± 6 yr) once received WP+KHCO 3 and once received a standardized isocaloric diet. Muscle biopsies were taken 2 days before and during the 19th day of bed rest (BR) from the soleus (SOL) and vastus lateralis (VL) muscle. Whole-body aerobic power (V̇o 2 max ), muscle fatigue, and isometric strength of knee extensor and plantar flexor muscles were monitored. Muscle fiber types and capillaries were identified by immunohistochemistry. Fiber oxidative capacity was determined as the optical density (OD) at 660 nm of succinate dehydrogenase (SDH)-stained sections. The product of fiber cross-sectional area and SDH-OD (integrated SDH) indicated the maximal oxygen consumption of that fiber. The maximal oxygen consumption supported by a capillary was calculated as the integrated SDH in its supply area. BR reduced isometric strength of knee extensor muscles (P < 0.05), and the fiber oxidative capacity (P < 0.001) and V̇o 2 max (P = 0.042), but had no significant impact on muscle capillarization or fatigue resistance of thigh muscles. The maximal oxygen consumption supported by a capillary was reduced by 24% in SOL and 16% in VL (P < 0.001). WP+KHCO 3 attenuated the disuse-induced reduction in fiber oxidative capacity in both muscles (P < 0.01). In conclusion, following 19 days of bed rest, the decrement in fiber oxidative capacity is proportionally larger than the loss of capillaries. WP+KHCO 3 appears to attenuate disuse-induced reductions in fiber oxidative capacity. Copyright © 2016 the American Physiological Society.

16. Emplacement no. 1, door to small communication room (L), ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. Emplacement no. 1, door to small communication room (L), delivery table for projectile at right - Fort Wadsworth Battery Romeyn B. Ayers, South side of Ayers Road, Staten Island, Rosebank, Richmond County, NY

11. Battery Richmond, emplacement no. 1, showing (LR): sealed location ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Battery Richmond, emplacement no. 1, showing (L-R): sealed location of delivery table for projectile hoist, recess for powder hoist - Forth Wadsworth Battery Richmond, Fort Wadsworth, Staten Island, New York County, NY

Emplacement of the La Peña alkaline igneous complex, Mendoza, Argentina (33° S): Implications for the early Miocene tectonic regime in the retroarc of the Andes

NASA Astrophysics Data System (ADS)

Pagano, D. S.; Galliski, M. A.; Márquez-Zavalía, M. F.

2014-03-01

The La Peña alkaline complex (LPC) of Miocene age (18-19 Ma) lies on the eastern front of the Precordillera (32°41ʹ34ʺS, 68°59ʹ48″W, 1400-2900 m a.s.l.), 30 km northwest of Mendoza city, Argentina. It is a subcircular massif of 19 km2 and 5 km in diameter, intruded in the metasedimentary sequence of the Villavicencio Formation of Silurian-Devonian age. It is the result of integration of multiple pulses derived from one or more deep magma chambers, which form a suite of silicate rocks grouped into: a clinopyroxenite body, a central syenite facies with a large breccia zone at the contact with the clinopyroxenite, bodies of malignite, trachyte and syenite porphyry necks, and a system of radial and annular dikes of different compositions. Its subcircular geometry and dike system distribution are frequent features of intraplate plutons or plutons emplaced in post-orogenic settings. These morphostructural features characterize numerous alkaline complexes worldwide and denote the importance of magmatic pressures that cause doming with radial and annular fracturing, in a brittle country rock. However, in the LPC, the attitude of the internal fabric of plutonic and subvolcanic units and the preferential layout of dikes match the NW-SE extensional fractures widely distributed in the host rock. This feature indicates a strong tectonic control linked to the structure that facilitate space for emplacement, corresponding to the brittle shear zone parallel to the N-S stratigraphy of the country rock. Shearing produced a system of discontinuities, with a K fractal fracture pattern, given by the combination of Riedel (R), anti-Riedel (R‧), (P) and extensional (T) fracture systems, responsible for the control of melt migration by the opening of various fracture branches, but particularly through the NW-SE (T) fractures. Five different pulses would have ascent, (1) an initial one from which cumulate clinopyroxenite was formed, (2) a phase of mafic composition represented by dikes cross-cutting the clinopyroxenite, (3) a malignite facies that causes a small breccia in the clinopyroxenite, (4) a central syenite facies that develops breccias at the contact with the clinopyroxenite and, finally, (5) porphyry necks and a system of radial dikes intruding all units. At the moment of the emplacement different mechanisms would have acted, they summarized in: 1) opening of discontinuities synchronous to the magma circulation as the principal mechanism for formation of dikes and conduits; 2) stoping processes, that play an important role in the development of the breccia zone and enabling an efficient transference of material during the emplacement of the syenitic magma and 3) shear-related deformation (regional stress), affected the internal fabric of the facies, causing intracrystalline deformation and submagmatic flow, which is very evident in the central syenite intrusive. The kinematic analysis of shear planes allows proposing that emplacement of the LPC took place in a transtensive regime, which would have occurred in the back-arc of the Andes orogen, during a long period spanning from Miocene to the present, of the compressive deformation responsible, westward and at the same latitude, for the development of the Aconcagua fold and thrust belt.

Thermochronology of the Cornubian batholith in southwest England: Implications for pluton emplacement and protracted hydrothermal mineralization

NASA Astrophysics Data System (ADS)

Chesley, J. T.; Halliday, A. N.; Snee, L. W.; Mezger, K.; Shepherd, T. J.; Scrivener, R. C.

1993-04-01

The metalliferous ore deposits of southwest England are associated with biotite-muscovite granites that intruded upper Paleozoic sediments and volcanic rocks at the end of the Hercynian Orogeny. The hydrothermal mineralization can be subdivided into four stages: (1) exoskarns (2) high-temperature tin and tungsten oxide-bearing sheeted greisen bordered veins and Sn-bearing tourmaline veins and breccias (3) polymetallic quartz-tourmaline-chlorite-sulfide-fluorite-bearing fissure veins, which represent the main episode of economic mineralization (4) late-stage, low-temperature polymetallic fluorite veins. U-Pb dating of monazite and xenotime and 40Ar /39Ar dating of muscovite were used to determine emplacement ages and cooling times for individual plutons within the Cornubian batholith, as well as separate intrusive phases within the plutons. In addition, 40Ar /39Ar ages from hornblende and secondary muscovite and Sm-Nd isochron ages from fluorite were employed to determine the relationship between pluton emplacement and different stages of mineralization. The U-Pb ages indicate that granite magmatism was protracted from ~300 Ma down to ~275 Ma with no evidence of a major hiatus. There is no systematic relation between the age of a pluton and its location within the batholith. The U-Pb ages for separate granite phases within a single pluton are resolvable and indicate that magma emplacement within individual plutons occurred over periods of as much as 4.5 myrs. Felsic porphyry dike emplacement was coeval with plutonism, but continued to ~270 Ma. The geochronologic data suggest that the Cornubian batholith originated from repeated melting events over 30 myrs and was formed by a series of small coalescing granitic bodies. Cooling rates of the main plutons are unrelated to emplacement age, but decrease from the southwest to the northeast from ~210°C myr -1 to ~60°C myr -1 with a mean of 100°C myr -1. These slow cooling rates appear to reflect the addition of heat from multiple intrusive episodes. The mineralization history is distinct for each pluton and ranges from coeval with, to up to 40 myrs younger than the cooling age for the host pluton. Stage 2 mineralization is broadly synchronous with the emplacement of granite magmas, is dominated by fluids expelled during crystallization, and may be repeated by the emplacement of younger magmas within the same pluton. Sm-Nd isochrons for fluorite from stage 3 polymetallic mineralization give ages of 259 ± 7, 266 ± 3 and 267 ± 12 Ma, postdating stage 2 mineralization by up to 25 myrs within the same deposit. The similarity in age of the main polymetallic mineralization hosted by the oldest and youngest plutons, suggests that this stage of mineralization is unlikely to be related to hydrothermal circulation driven by the emplacement and cooling of the host granite. The mineralization is more likely the product of regional hydrothermal circulation driven by heat from the emplacement and crystallization of younger buried pulses of magma.

Thermochronology of the Cornubian batholith in southwest England: Implications for pluton emplacement and protracted hydrothermal mineralization

USGS Publications Warehouse

Chesley, J.T.; Halliday, A.N.; Snee, L.W.; Mezger, K.; Shepherd, T.J.; Scrivener, R.C.

1993-01-01

The metalliferous ore deposits of southwest England are associated with biotite-muscovite granites that intruded upper Paleozoic sediments and volcanic rocks at the end of the Hercynian Orogeny. The hydrothermal mineralization can be subdivided into four stages: 1. (1) exoskarns 2. (2) high-temperature tin and tungsten oxide-bearing sheeted greisen bordered veins and Sn-bearing tourmaline veins and breccias 3. (3) polymetallic quartz-tourmaline-chlorite-sulfide-fluorite-bearing fissure veins, which represent the main episode of economic mineralization 4. (4) late-stage, low-temperature polymetallic fluorite veins. U-Pb dating of monazite and xenotime and 40Ar 39Ar dating of muscovite were used to determine emplacement ages and cooling times for individual plutons within the Cornubian batholith, as well as separate intrusive phases within the plutons. In addition, 40Ar 39Ar ages from hornblende and secondary muscovite and Sm-Nd isochron ages from fluorite were employed to determine the relationship between pluton emplacement and different stages of mineralization. The U-Pb ages indicate that granite magmatism was protracted from ~300 Ma down to ~275 Ma with no evidence of a major hiatus. There is no systematic relation between the age of a pluton and its location within the batholith. The U-Pb ages for separate granite phases within a single pluton are resolvable and indicate that magma emplacement within individual plutons occurred over periods of as much as 4.5 myrs. Felsic porphyry dike emplacement was coeval with plutonism, but continued to ~270 Ma. The geochronologic data suggest that the Cornubian batholith originated from repeated melting events over 30 myrs and was formed by a series of small coalescing granitic bodies. Cooling rates of the main plutons are unrelated to emplacement age, but decrease from the southwest to the northeast from ~210??C myr-1 to ~60??C myr-1 with a mean of 100??C myr-1. These slow cooling rates appear to reflect the addition of heat from multiple intrusive episodes. The mineralization history is distinct for each pluton and ranges from coeval with, to up to 40 myrs younger than the cooling age for the host pluton. Stage 2 mineralization is broadly synchronous with the emplacement of granite magmas, is dominated by fluids expelled during crystallization, and may be repeated by the emplacement of younger magmas within the same pluton. Sm-Nd isochrons for fluorite from stage 3 polymetallic mineralization give ages of 259 ?? 7, 266 ?? 3 and 267 ?? 12 Ma, postdating stage 2 mineralization by up to 25 myrs within the same deposit. The similarity in age of the main polymetallic mineralization hosted by the oldest and youngest plutons, suggests that this stage of mineralization is unlikely to be related to hydrothermal circulation driven by the emplacement and cooling of the host granite. The mineralization is more likely the product of regional hydrothermal circulation driven by heat from the emplacement and crystallization of younger buried pulses of magma. ?? 1993.

Extremely High Magma Emplacement Rates Recorded in the Golden Horn Batholith, WA

NASA Astrophysics Data System (ADS)

Eddy, M. P.; Bowring, S. A.; Tepper, J. H.; Miller, R. B.

2015-12-01

High SiO2 rhyolites emplaced during 'super-eruptions' demonstrate that large volumes of eruptible magma can exist in the upper crust. However, the timescale over which the magma reservoirs that source these eruptions are built remains controversial. Thermal models suggest that magma emplacement rates need to be > 0.005-0.01 km3/yr in order to accumulate enough eruptible magma to source a 'super-eruption'. Yet, these rates are higher than the time-averaged rates (< 0.001 km3/yr) for nearly all well-studied granitoid plutonic complexes. This disparity contradicts geologic evidence suggesting that the high SiO2 rhyolites emplaced during 'super-eruptions' are extracted from crystal rich magma chambers that should be preserved in the geologic record as granodioritic and granitic plutons. We quantify time-averaged magma emplacement rates for the upper crustal Golden Horn batholith, WA based on new geologic mapping and U-Pb zircon CA-IDTIMS geochronology. The batholith is exposed over 310 km3 and can be separated in the field into five intrusive units. High topography allows the 3D geometry of each phase to be constrained and their volumes range from < 100 km3 to > 400 km3. U-Pb zircon geochronology reveals that four of the five phases were assembled incrementally and distinct zircon populations from samples within these phases suggest that individual magmatic pulses had fully crystallized before the next arrived. However, six nearly identical U-Pb zircon dates from a > 400 km3 rapakivi granite show that this phase was built in ca. 50 kyr and that large portions may have been emplaced nearly simultaneously. The implied emplacement rate for this phase (≥ 0.008 km3/yr) is in agreement with those predicted for assembly of the upper crustal magma chambers that source 'super-eruptions', and it may provide a rare and unprecedented opportunity to study the processes that occur in such chambers.

Eruption and emplacement dynamics of a thick trachytic lava flow of the Sancy volcano (France)

NASA Astrophysics Data System (ADS)

Latutrie, Benjamin; Harris, Andrew; Médard, Etienne; Gurioli, Lucia

2017-01-01

A 70-m-thick, 2200-m-long (51 × 106 m3) trachytic lava flow unit underlies the Puy de Cliergue (Mt. Dore, France). Excellent exposure along a 400-m-long and 60- to 85-m-high section allows the flow interior to be accessed on two sides of a glacial valley that cuts through the unit. We completed an integrated morphological, structural, textural, and chemical analysis of the unit to gain insights into eruption and flow processes during emplacement of this thick silicic lava flow, so as to elucidate the chamber and flow dynamic processed that operate during the emplacement of such systems. The unit is characterized by an inverse chemical stratification, where there is primitive lava beneath the evolved lava. The interior is plug dominated with a thin basal shear zone overlying a thick basal breccia, with ramping affecting the entire flow thickness. To understand these characteristics, we propose an eruption model that first involves processes operating in the magma chamber whereby a primitive melt is injected into an evolved magma to create a mixed zone at the chamber base. The eruption triggered by this event first emplaced a trachytic dome, into which banded lava from the chamber base was injected. Subsequent endogenous dome growth led to flow down the shallow slope to the east on which the highly viscous (1012 Pa s) coulée was emplaced. The flow likely moved extremely slowly, being emplaced over a period of 4-10 years in a glacial manner, where a thick (>60-m) plug slid over a thin (5-m-thick) basal shear zone. Excellent exposure means that the Puy de Cliergue complex can be viewed as a case type location for understanding and defining the eruption and emplacement of thick, high-viscosity, silicic lava flow systems.

Rapid Intradeformational Emplacement of the Big Hole Canyon Pluton Into the Sevier Fold-Thrust Belt, Southwest Montana.

NASA Astrophysics Data System (ADS)

Hespenheide, M. A.

2002-12-01

The Big Hole Canyon pluton (BHCp) is a Late Cretaceous pluton emplaced within the Sevier fold-and-thrust belt of the western North American Cordillera. The pluton is exposed over 60km2 and a thickness of ~1400m. Combined anisotropy of magnetic susceptibility (AMS), structural, and field studies document a clear pattern of magmatic flow radiating from at least three subvertical conduits <100m wide and ~300 to ~800m long. Interpreted flow plunges change rapidly to subhorizontal fabrics across the rest of the pluton, matching the expected pattern for laccolithic emplacement. Ascent conduits within the Big Hole Canyon pluton are coincident with the fold axis of an anticline above a thrust ramp, suggesting that the magma ascended up the fault of the fault-bend-fold. Geobarometry and stratigraphic reconstructions indicate an emplacement depth of approximately ~3km. Preliminary thermal modeling indicates that the BHCp was emplaced in 250,000 years, likely between periods of regional shortening deformation. Rapid magma ascent rates calculated by dike flow modeling and implied by entrained wall-rock xenoliths may indicate sequential magma injection into the pluton; an absence of chill margins between phases within the pluton indicates that sequential injections must have taken place quickly enough that the magmas did not have time to cool below the solidus temperature. The geometry and location of the BHCp suggest that magma used a pre-existing fault as a mechanical discontinuity for both ascent and emplacement. Continued intrusion of magma had a sufficient amount of driving pressure to stretch, shear, and lift the roof of the pluton. Detailed field mapping, structural studies, AMS, and thermobarometry indicate that the Late Cretaceous Big Hole Canyon pluton was emplaced as a laccolith at the top of a pre-existing fault-bend-fold in the frontal portion of the Sevier fold-thrust belt.

Exploring Inflated Pahohoe Lava Flow Morphologies and the Effects of Cooling Using a New Simulation Approach

NASA Technical Reports Server (NTRS)

Glaze, L. S.; Baloga, S. M.

2014-01-01

Pahoehoe lavas are recognized as an important landform on Earth, Mars and Io. Observations of such flows on Earth (e.g., Figure 1) indicate that the emplacement process is dominated by random effects. Existing models for lobate a`a lava flows that assume viscous fluid flow on an inclined plane are not appropriate for dealing with the numerous random factors present in pahoehoe emplacement. Thus, interpretation of emplacement conditions for pahoehoe lava flows on Mars requires fundamentally different models. A new model that implements a simulation approach has recently been developed that allows exploration of a variety of key influences on pahoehoe lobe emplacement (e.g., source shape, confinement, slope). One important factor that has an impact on the final topographic shape and morphology of a pahoehoe lobe is the volumetric flow rate of lava, where cooling of lava on the lobe surface influences the likelihood of subsequent breakouts.

Pluton emplacement in a releasing bend in a transpressive regime: the arrozal granite in the Paraíba do Sul shear belt, Rio de Janeiro.

PubMed

Nummer, Alexis R; Machado, Rômulo; Dehler, Nolan M

2007-06-01

The Arrozal Granite, situated in the southwestern region of the State of Rio de Janeiro, has a granitic to granodioritic composition. It contains a strong mylonitic foliation along its border, passing gradually to a well-developed magmatic foliation towards its center. Structural analysis indicates that the Arrozal Granite was emplaced along the Além-Paraíba Shear Zone in a dextral transpressive tectonic regime. A regional shift of the trend along this shear zone from NE-SW to E-W, observed in the area, is interpreted to be casually related to the creation of space for the emplacement of the granite. Our data indicate that releasing bends may have played an important role for space generation during the emplacement of the Arrozal Granite and other plutons.

Waste Handling and Emplacement Options for Disposal of Radioactive Waste in Deep Boreholes.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cochran, John R.; Hardin, Ernest

2015-11-01

Traditional methods cannot be used to handle and emplace radioactive wastes in boreholes up to 16,400 feet (5 km) deep for disposal. This paper describes three systems that can be used for handling and emplacing waste packages in deep borehole: (1) a 2011 reference design that is based on a previous study by Woodward–Clyde in 1983 in which waste packages are assembled into “strings” and lowered using drill pipe; (2) an updated version of the 2011 reference design; and (3) a new concept in which individual waste packages would be lowered to depth using a wireline. Emplacement on coiled tubingmore » was also considered, but not developed in detail. The systems described here are currently designed for U.S. Department of Energy-owned high-level waste (HLW) including the Cesium- 137/Strontium-90 capsules from the Hanford Facility and bulk granular HLW from fuel processing in Idaho.« less

Regional stratigraphy and geologic history of Mare Crisium

NASA Technical Reports Server (NTRS)

Head, J. W., III; Adams, J. B.; Mccord, T. B.; Pieters, C.; Zisk, S.

1978-01-01

Remote sensing and Luna 24 sample data are used to develop a summary of the regional stratigraphy and geologic history of Mare Crisium. Laboratory spectra of Luna 24 samples, telescopic reflectance spectra in the 0.3 to 1.1 micron range and orbital X-ray data have identified three major basalt groups in the region. Group I soil is derived from iron- and magnesium-rich titaniferous basalts and was apparently emplaced over the majority of the basin, however is presently exposed as a shelf in the southwest part. Group II soils, derived from very low titanium ferrobasalts, were emplaced in two stages subsequent to Group I emplacement and now appear as part of the outer shelf and topographic annulus. Subsidence of the basin interior preceded and continued after the emplacement of the third basalt group, a soil derived from a low titanium ferrobasalt. The Luna 24 site is found to be within a patch of Group II material.

On thermohydrologic conditions near high-level nuclear wastes emplaced in partially saturated fractured tuff: 1. Simulation studies with explicit consideration of fracture effects

NASA Astrophysics Data System (ADS)

Pruess, K.; Wang, J. S. Y.; Tsang, Y. W.

1990-06-01

We have performed modeling studies on the simultaneous transport of heat, liquid water, vapor, and air in partially saturated, fractured porous rock. Formation parameters were chosen as representative of the potential nuclear waste repository site in the Topopah Spring unit of the Yucca Mountain tuffs. The presence of fractures makes the transport problem very complex, both in terms of flow geometry and physics. The numerical simulator used for our flow calculations takes into account most of the physical effects believed to be important in multiphase fluid and heat flow. It has provisions for handling the extreme nonlinearities that arise in phase transitions, component disappearances, and capillary discontinuities at fracture faces. We model a region around an infinite linear string of nuclear waste canisters, taking into account both the discrete fractures and the porous matrix. Thermohydrologic conditions in the vicinity of the waste packages are found to depend strongly on relative permeability and capillary pressure characteristics of the fractures, which are unknown at the present time. If liquid held on the rough walls of drained fractures is assumed to be mobile, strong heat pipe effects are predicted. Under these conditions the host rock will remain in two-phase conditions right up to the emplacement hole, and formation temperatures will peak near 100°C. If it is assumed that liquid cannot move along drained fractures, the region surrounding the waste packages is predicted to dry up, and formation temperatures will rise beyond 200°C. A substantial fraction of waste heat can be removed if emplacement holes are left open and ventilated, as opposed to backfilled and sealed emplacement conditions. Comparing our model predictions with observations from in situ heater experiments reported by Zimmerman and coworkers, some intriguing similarities are noted. However, for a quantitative evaluation, additional carefully controlled laboratory and field experiments will be needed.

Comparative Effectiveness of Insecticides for Use Against the House Fly (Diptera: Muscidae): Determination of Resistance Levels on a Malaysian Poultry Farm.

PubMed

Ong, Song-Quan; Ahmad, Hamdan; Jaal, Zairi; Rus, Adanan Che

2016-02-01

In this study, the toxicology of two commercial larvicides--cyromazine (Neporex 50SP) and ChCy (combination of chlorpyrifos and cypermethrin, Naga 505)--and five commercial adulticides--thiamethoxam (Agita 10WG), cyfluthrin (Responsar WP), lambda-cyhalothrin (Icon 2.8EC), fipronil (Regent 50SC), and imidacloprid (Toxilat 10WP)--was examined against the WHO/VCRU (World Health Organization/ Vector Control Research Unit) susceptible strain and the AYTW (Ayer Tawar) field strain of house fly, Musca domestica L. These pesticides were administered topically, in the diet, or as a dry residue treatment on plywood. Probit analysis using at least five concentrations and the concentration that was lethal to 50% (LC(50)) of the organisms was applied to compare the toxicology and resistance levels of the AYTW population to different insecticides. In the larvicide laboratory study, ChCy was more effective than cyromazine, with a significantly lower LC(50) value when administered topically or in the diet, although the AYTW population was susceptible to both larvicides with a resistance ratio (RR) <10. For the adulticide laboratory study, cyfluthrin and fipronil exhibited the lowest LC50 values of the adulticides, indicating that they are both effective at controlling adult flies, although lambda-cyhalothrin showed moderate resistance (RR = 11.60 by topical application; 12.41 by plywood treatment). Further investigation of ChCy, cyromazine, cyfluthrin, and fipronil under field conditions confirmed that ChCy and cyromazine strikingly reduced larval density, and surprisingly, ChCy also exhibited adulticidal activity, which significantly reduced adult fly numbers compared with the control group. Cyfluthrin and fipronil were also confirmed to be effective, with a significant reduction in adult fly numbers compared with the control group. © The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

AmeriFlux CA-WP1 Alberta - Western Peatland - LaBiche River,Black Spruce/Larch Fen

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flanagan, Lawrence B.

This is the AmeriFlux version of the carbon flux data for the site CA-WP1 Alberta - Western Peatland - LaBiche River,Black Spruce/Larch Fen. Site Description - Latitude: 54.9538359° N Longitude: 112.4669767° W, the site is dominated by stunted trees of Larix laricina and Picea mariana, with Betula pumila, Ledum groenlandicum and Salix sp. (shrubs) and a wide range of moss species. There is also an abundant dwarf-shrub and herb layer including: Andromeda polifolia, Carex sp., Empetrum nigrum, Menyanthese trifoliata, Oxycoccus microcarpus, Potentilla palustris, Rubus acaulis, Smilacina trifolia, Vaccinium vitis-idea.

Circadian Patterns of Wikipedia Editorial Activity: A Demographic Analysis

PubMed Central

Yasseri, Taha; Sumi, Robert; Kertész, János

2012-01-01

Wikipedia (WP) as a collaborative, dynamical system of humans is an appropriate subject of social studies. Each single action of the members of this society, i.e., editors, is well recorded and accessible. Using the cumulative data of 34 Wikipedias in different languages, we try to characterize and find the universalities and differences in temporal activity patterns of editors. Based on this data, we estimate the geographical distribution of editors for each WP in the globe. Furthermore we also clarify the differences among different groups of WPs, which originate in the variance of cultural and social features of the communities of editors. PMID:22272279

Descriptive and injunctive norms of waterpipe smoking among college students.

PubMed

Leavens, Eleanor L S; Brett, Emma I; Morgan, Taylor L; Lopez, Susanna V; Shaikh, Raees A; Leffingwell, Thad R; Wagener, Theodore L

2018-02-01

Smoking tobacco via a waterpipe (WP) is on the rise, particularly among college students. One reason for this may be normative perceptions of WP tobacco smoking (WTS) among this population. The current study examined the perceived and actual descriptive and injunctive norms of WTS among a college student sample. Participants were 894 college students enrolled at a large, Midwestern university. Participants completed measures of WTS frequency and quantity and perceived/actual descriptive and injunctive norms of WTS. Over one-third of the sample reported ever trying WTS, while only 2% reported current (past month) use. When comparing ever and never WP smokers, ever smokers reported greater perceived peer approval of WTS. Both males and females overestimated WTS frequency of same-sex students at their university. The current study is one of the first to investigate descriptive and injunctive norms of WTS among college students. Students who report WTS are more likely to overestimate descriptive norms of WTS among their peers, suggesting corrective normative feedback regarding actual use by peers may be an important target for WTS intervention among college students. Future research should investigate the temporal association between normative perceptions and WTS behaviors among college students. Copyright © 2017 Elsevier Ltd. All rights reserved.

The boomerang effect in electron-hydrogen molecule scattering as determined by time-dependent calculations

NASA Astrophysics Data System (ADS)

Ben-Asher, Anael; Moiseyev, Nimrod

2017-05-01

The appearance of oscillations in the energy-dependent cross sections of the vibrational excitation ν =0 →ν ≥3 of the hydrogen molecule in its electronic ground state as predicted by Mündel, Berman, and Domcke [Phys. Rev. A 32, 181 (1985)] was confirmed in the electron scattering experiments by Allan [J. Phys. B: At. Mol. Phys. 18, L451 (1985)]. These unusual structures were obtained in spite of the extremely short lifetime of H2- in its ro-vibrational states. Based on the standard (Hermitian) time-independent scattering calculations, Horáček et al. [Phys. Rev. A 73, 022701 (2006)] associated these oscillations with the boomerang effect. Here, we show the boomerang effect as developed in time, based on our time-dependent nuclear wavepacket (WP) calculations. The nuclear WP dynamics of H2- is determined using the non-Hermitian quantum mechanics (NH-QM) which enables the use of the Born-Oppenheimer approximation with complex potential energy surfaces. This NH-QM approach, which enables us the association of the nuclear WP dynamics as obtained from the complex potential energy curve of H2- with the evolution of cross section in time, can enlighten the dynamics in other scattering experiments.

The boomerang effect in electron-hydrogen molecule scattering as determined by time-dependent calculations.

PubMed

Ben-Asher, Anael; Moiseyev, Nimrod

2017-05-28

The appearance of oscillations in the energy-dependent cross sections of the vibrational excitation ν=0→ν≥3 of the hydrogen molecule in its electronic ground state as predicted by Mündel, Berman, and Domcke [Phys. Rev. A 32, 181 (1985)] was confirmed in the electron scattering experiments by Allan [J. Phys. B: At. Mol. Phys. 18, L451 (1985)]. These unusual structures were obtained in spite of the extremely short lifetime of H 2 - in its ro-vibrational states. Based on the standard (Hermitian) time-independent scattering calculations, Horáček et al. [Phys. Rev. A 73, 022701 (2006)] associated these oscillations with the boomerang effect. Here, we show the boomerang effect as developed in time, based on our time-dependent nuclear wavepacket (WP) calculations. The nuclear WP dynamics of H 2 - is determined using the non-Hermitian quantum mechanics (NH-QM) which enables the use of the Born-Oppenheimer approximation with complex potential energy surfaces. This NH-QM approach, which enables us the association of the nuclear WP dynamics as obtained from the complex potential energy curve of H 2 - with the evolution of cross section in time, can enlighten the dynamics in other scattering experiments.

Brain synchronization during perception of facial emotional expressions with natural and unnatural dynamics

PubMed Central

Volhard, Jakob; Müller, Viktor; Kaulard, Kathrin; Brick, Timothy R.; Wallraven, Christian; Lindenberger, Ulman

2017-01-01

Research on the perception of facial emotional expressions (FEEs) often uses static images that do not capture the dynamic character of social coordination in natural settings. Recent behavioral and neuroimaging studies suggest that dynamic FEEs (videos or morphs) enhance emotion perception. To identify mechanisms associated with the perception of FEEs with natural dynamics, the present EEG (Electroencephalography)study compared (i) ecologically valid stimuli of angry and happy FEEs with natural dynamics to (ii) FEEs with unnatural dynamics, and to (iii) static FEEs. FEEs with unnatural dynamics showed faces moving in a biologically possible but unpredictable and atypical manner, generally resulting in ambivalent emotional content. Participants were asked to explicitly recognize FEEs. Using whole power (WP) and phase synchrony (Phase Locking Index, PLI), we found that brain responses discriminated between natural and unnatural FEEs (both static and dynamic). Differences were primarily observed in the timing and brain topographies of delta and theta PLI and WP, and in alpha and beta WP. Our results support the view that biologically plausible, albeit atypical, FEEs are processed by the brain by different mechanisms than natural FEEs. We conclude that natural movement dynamics are essential for the perception of FEEs and the associated brain processes. PMID:28723957

WAG 2 remedial investigation and site investigation site-specific work plan/health and safety checklist for the soil and sediment task. Environmental Restoration Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holt, V.L.; Burgoa, B.B.

1993-12-01

This document is a site-specific work plan/health and safety checklist (WP/HSC) for a task of the Waste Area Grouping 2 Remedial Investigation and Site Investigation (WAG 2 RI&SI). Title 29 CFR Part 1910.120 requires that a health and safety program plan that includes site- and task-specific information be completed to ensure conformance with health- and safety-related requirements. To meet this requirement, the health and safety program plan for each WAG 2 RI&SI field task must include (1) the general health and safety program plan for all WAG 2 RI&SI field activities and (2) a WP/HSC for that particular field task.more » These two components, along with all applicable referenced procedures, must be kept together at the work site and distributed to field personnel as required. The general health and safety program plan is the Health and Safety Plan for the Remedial Investigation and Site Investigation of Waste Area Grouping 2 at the Oak Ridge National Laboratory, Oak Ridge, Tennessee (ORNL/ER-169). The WP/HSCs are being issued as supplements to ORNL/ER-169.« less

Brain synchronization during perception of facial emotional expressions with natural and unnatural dynamics.

PubMed

Perdikis, Dionysios; Volhard, Jakob; Müller, Viktor; Kaulard, Kathrin; Brick, Timothy R; Wallraven, Christian; Lindenberger, Ulman

2017-01-01

Research on the perception of facial emotional expressions (FEEs) often uses static images that do not capture the dynamic character of social coordination in natural settings. Recent behavioral and neuroimaging studies suggest that dynamic FEEs (videos or morphs) enhance emotion perception. To identify mechanisms associated with the perception of FEEs with natural dynamics, the present EEG (Electroencephalography)study compared (i) ecologically valid stimuli of angry and happy FEEs with natural dynamics to (ii) FEEs with unnatural dynamics, and to (iii) static FEEs. FEEs with unnatural dynamics showed faces moving in a biologically possible but unpredictable and atypical manner, generally resulting in ambivalent emotional content. Participants were asked to explicitly recognize FEEs. Using whole power (WP) and phase synchrony (Phase Locking Index, PLI), we found that brain responses discriminated between natural and unnatural FEEs (both static and dynamic). Differences were primarily observed in the timing and brain topographies of delta and theta PLI and WP, and in alpha and beta WP. Our results support the view that biologically plausible, albeit atypical, FEEs are processed by the brain by different mechanisms than natural FEEs. We conclude that natural movement dynamics are essential for the perception of FEEs and the associated brain processes.

An algorithm to estimate PBL heights from wind profiler data

NASA Astrophysics Data System (ADS)

Molod, A.; Salmun, H.

2016-12-01

An algorithm was developed to estimate planetary boundary layer (PBL) heights from hourlyarchived wind profiler data from the NOAA Profiler Network (NPN) sites located throughoutthe central United States from the period 1992-2012. The long period of record allows ananalysis of climatological mean PBL heights as well as some estimates of year to yearvariability. Under clear conditions, summertime averaged hourly time series of PBL heightscompare well with Richardson-number based estimates at the few NPN stations with hourlytemperature measurements. Comparisons with clear sky MERRA estimates show that the windprofiler (WP) and the Richardson number based PBL heights are lower by approximately 250-500 m.The geographical distribution of daily maximum WP PBL heights corresponds well with theexpected distribution based on patterns of surface temperature and soil moisture. Windprofiler PBL heights were also estimated under mostly cloudy conditions, but the WP estimatesshow a smaller clear-cloudy condition difference than either of the other two PBL height estimates.The algorithm presented here is shown to provide a reliable summer, fall and springclimatology of daytime hourly PBL heights throughout the central United States. The reliabilityof the algorithm has prompted its use to obtain hourly PBL heights from other archived windprofiler data located throughout the world.

Comparison of three different methods to prevent heat loss in healthy dogs undergoing 90 minutes of general anesthesia.

PubMed

Clark-Price, Stuart C; Dossin, Olivier; Jones, Katherine R; Otto, Angela N; Weng, Hsin-Yi

2013-05-01

To compare a towel under, a warm water pad under or a forced warm air blanket over dogs as techniques to reduce heat loss during a standardized anesthetic. Prospective, randomized, crossover study. Eight, healthy, mixed breed dogs weighing 16.3-19.6 kg. Dogs were anesthetized four times for 90 minutes. Dogs were placed on a steel table (treatment TA), with a cotton towel (treatment TO) or a circulating warm water pad (treatment WP) between the dog and the table, or with, a towel under the dog and covered with a forced warm air blanket (treatment WAB). Rectal temperature (RT) was recorded at 5 minute intervals. Changes in temperature (ΔRT) were calculated as the RT at a given point subtracted from the RT before anesthesia (baseline) and compared over time. After 90 minutes of anesthesia, the ΔRT was 3.42 °C ± 0.29 for TA, 2.78 °C ± 0.43 for TO, 1.98 °C ± 0.29 for WP, and 0.91 °C ± 0.27 for WAB. Significant differences in ΔRT occurred between TA and WAB at 20 minutes (0.94 °C ± 0.42, p = 0.0206), between TO and WAB at 30 minutes (1.16 °C ± 0.62, p = 0.0063), between WP and WAB at 50 minutes (0.96 °C ± 0.98, p = 0.0249), between TA and WP at 35 minutes (1.19 °C ± 0.54, p = 0.0091), between TO and WP at 70 minutes (1.12 °C ± 0.56, p = 0.0248), and between TA and TO at 75 minutes (0.96 °C ± 0.62, p = 0.0313). These differences in ΔRT between each treatment persisted from the times indicated until the end of the anesthesia. During anesthesia, forced warm air blankets were superior to other methods tested for limiting heat loss. An efficient heat loss technique should be used for anesthesia longer than 20 minutes duration in medium sized dogs. © 2013 The Authors. Veterinary Anaesthesia and Analgesia © 2013 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.

Study on reproductive performance of Holstein x Lai Sind crossbred dairy heifers and cows at smallholdings in Ho Chi Minh City, Vietnam.

PubMed

Nguyen-Kien, Cuong; Van Khanh, Nguyen; Hanzen, Christian

2017-03-01

The reproductive performance of Holstein x Lai Sind crossbred dairy heifers and cows was evaluated at smallholdings in Ho Chi Minh City (HCMC). The data of 232 heifers and 244 cows (261 lactations) from 35 small dairy farms was collected over a 2-year period, from 2013 to 2014. The overall mean for age at first service (AFS), days between first and last service (DFLS), and age at conception (AC) of heifers was 479 (±80), 38 (±80), and 517 (±114) days, respectively. Average number of services per conception (NSC), conception rate (CR), and conception rate at first service (CRFS) was 1.8 (±1.4), 55, and 58%, respectively. The overall mean for the waiting period (WP), DFLS, and days open (DO) of cows was 109 (±52), 133 (±114), and 242 (±129) days, respectively. The mean for NSC, CR, and CRFS was 4.3 (±2.7), 23, and 14%, respectively. A very significant decrease in AFS and AC according to the year of birth, and a significant increase in AFS according to body weight at first insemination (>320 kg) were observed. The CRFS of heifers inseminated in 2013 was significantly higher than in 2014. Monthly mean CR in heifers and cows was negatively correlated with THI. The WP, DFLS, DO, and NSC of cows significantly decreased according to the year of calving. Cows that calved in rainy season had a significantly longer WP than in dry season. The occurrence of postpartum (PP) diseases was accompanied by an increase in WP, DO, and NSC. A decrease in body condition score (BCS) between calving and 60th day (C60) and also between 60th and 120th day of lactation resulted in a significant increase in WP and DO. A decrease in BCS between C60 was also accompanied by a considerable reduction in CRFS of cows. Season and BCS at insemination had a significant effect on NSC and CR of cows. Reproductive performance was satisfactory for heifers, but poor for cows. Losses of BCS during the first months of lactation and at insemination were the major risk factors for this poor performance. Moreover, the season had a more negative effect on fertility in cows than in heifers.

Depleted deep South China Sea δ13C paleoceanographic events in response to tectonic evolution in Taiwan-Luzon Strait since Middle Miocene

NASA Astrophysics Data System (ADS)

Chen, Wen-Huang; Huang, Chi-Yue; Lin, Yen-Jun; Zhao, Quanhong; Yan, Yi; Chen, Duofu; Zhang, Xinchang; Lan, Qing; Yu, Mengming

2015-12-01

The most distinctive feature of the deep South China Sea (SCS) paleoceanography is the occurrence of long-term depleted deep-sea benthic foraminiferal δ13C values. They are lower than the global and the Pacific composite records in the last 16 Ma, especially at 13.2, 10.5, 6.5, 3.0 and 1.2-0.4 Ma. This distinct deep SCS paleoceanograhic history coincides with the subduction-collision history in the Taiwan region where waters of the West Pacific (WP) and the SCS exchange. The depleted deep-sea benthic foraminiferal δ13C events indicate that the SCS deep basin became progressively a stagnant environment in the last 16 Ma due to either closure of the connection with the WP bottom water or temporary reduction of the WP deep water flowing into the deep SCS. Both the Taiwan accretionary prism and the Luzon arc became the main tectono-morphological barriers for the WP bottom water flowing into the SCS deep basin when eastward subduction of the SCS oceanic lithosphere beneath the Philippine Sea Plate started from the Middle Miocene (18-16 Ma). This began a long-term trend of depleted SCS deep-sea benthic δ13C values in the last 16 Ma. The oblique arc-continent collision since ~6.5 Ma uplifted the Taiwan accretionary prism rapidly above sea level and further isolated the SCS from the open Pacific. The collision simultaneously causes backthrusting deformations in the North Luzon Trough forearc basin and sequentially closes interarc water gates between volcanic islands from north to south. The Loho and the Taitung interarc water gates in the advanced collision zone were closed at ~3.0 Ma and ~1.2 Ma, coinciding with the very low SCS deep-sea benthic δ13C events at 3.0 and 1.2-0.4 Ma, respectively. The Taitung Canyon between the Lutao and Lanyu volcanic islands in the incipient collision zone is semi-closed presently. These closure events also lead to the result that the WP deep water intrudes westward into the SCS principally through the Bashi Channel between the Lanyu and Batan volcanic islands in the subduction zone.

Palaeomagnetic Emplacement Temperature Determinations of Pyroclastic and Volcaniclastic Deposits in Southern African Kimberlite Pipes

NASA Astrophysics Data System (ADS)

Fontana, G.; Mac Niocaill, C.; Brown, R.; Sparks, R. S.; Matthew, F.; Gernon, T. M.

2009-12-01

Kimberlites are complex, ultramafic and diamond-bearing volcanic rocks preserved in volcanic pipes, dykes and craters. The formation of kimberlite pipes is a strongly debated issue and two principal theories have been proposed to explain pipe formation: (1) the explosive degassing of magma, and (2) the interaction of rising magma with groundwater (phreatomagmatism). Progressive thermal demagnetization studies are a powerful tool for determining the emplacement temperatures of ancient volcanic deposits and we present the first application of such techniques to kimberlite deposits. Lithic clasts were sampled from a variety of lithofacies, from three pipes for which the internal geology is well constrained (A/K1 pipe, Orapa Mine, Botswana and the K1 and K2 pipes, Venetia Mine, South Africa). The sampled deposits included massive and layered vent-filling breccias with varying abundances of lithic inclusions and layered crater-filling pyroclastic deposits, talus breccias and volcaniclastic breccias. Lithic clasts sampled from layered and massive vent-filling pyroclastic deposits in A/K1 were emplaced at >590° C. Results from K1 and K2 provide a maximum emplacement temperature limit for vent-filling breccias of 420-460° C; and constrain equilibrium deposit temperatures at 300-340° C. Crater-filling volcaniclastic kimberlite breccias and talus deposits from A/K1 were emplaced at ambient temperatures, consistent with infilling of the pipe by post-eruption epiclastic processes. Identified within the epiclastic crater-fill succession is a laterally extensive 15-20 metre thick kimberlite pyroclastic flow deposit emplaced at temperatures of 220-440° C. It overlies the post-eruption epiclastic units and is considered an extraneous pyroclastic kimberlite deposit erupted from another kimberlite vent. The results provide important constraints on kimberlite emplacement mechanisms and eruption dynamics. Emplacement temperatures of >590°C for pipe-filling pyroclastic deposits are consistent with volatile-driven eruptions, and suggest phreatomagmatism did not play a major role in the generation of the deposits. The discovery of an extraneous pyroclastic flow deposit within the Orapa A/K1 epiclastic crater, which was erupted from another vent, suggests kimberlite eruptions are capable of producing sustained eruption columns and thick pyroclastic deposits involving significant transport away from source.

The emplacement, geochemistry and petrogenesis of two central Morocco Hercynian granites. Geotectonic implications

NASA Astrophysics Data System (ADS)

Giuliani, G.; Cheilletz, A.; Zimmermann, J. L.

New field, petrographic and geochemical data including REE, Rb-Sr, and K-Ar, are presented concerning the emplacement and petrogenesis of two calc-alkaline Moroccan Hercynian granites: the Zaër pluton and the Djebel Aouam stocks. Zonation in the Zaër pluton does not appear to result from simple fractional crystallization nor from hydrothermal alteration but is rather the diapiric intrusion of two interlocked bodies. REE geochemistry supports the interpretation that the biotite-granodiorite magma (301 ± 8.2 M.a.) and the Djebel Aouam stocks appear to have been derived by fusion of crustal materials with possible mantle contamination ( Initial87Sr/ 86Srratio = 0.70514 ). The second two-mica granitic magma (283.4 ± 6.2 M.a.) corresponds to a peraluminous granite (1.22 < A/ CNK < 1.33) generated by fusion of continental crust including mature sedimentarr materials (Initial 87Sr/ 86Sr ratio = 0.70836). These granites are compared to the Acadian granites of north Appalachian and classified in the «post-collision, uplift environmentå type. An illustrative four step model presenting the generation and emplacement of these two granites together with the associated W-Sn-Pb-Zn-Ag mineralizations is proposed: (1) first magma generation, (2) first melt emplacement, (3) second melt emplacement, (4) late convective flow.

Preliminary ECLSS waste water model

NASA Technical Reports Server (NTRS)

Carter, Donald L.; Holder, Donald W., Jr.; Alexander, Kevin; Shaw, R. G.; Hayase, John K.

1991-01-01

A preliminary waste water model for input to the Space Station Freedom (SSF) Environmental Control and Life Support System (ECLSS) Water Processor (WP) has been generated for design purposes. Data have been compiled from various ECLSS tests and flight sample analyses. A discussion of the characterization of the waste streams comprising the model is presented, along with a discussion of the waste water model and the rationale for the inclusion of contaminants in their respective concentrations. The major objective is to establish a methodology for the development of a waste water model and to present the current state of that model.

Making change easy: A peer-to-peer guide on transitioning to new hand hygiene products.

PubMed

Amirov, Chingiz M; Candon, Heather L; Jacob, Latha

2017-01-01

This report summarizes our experiences planning and implementing the transition to a new commercial line of hand hygiene products and their dispensing systems in a large academic health care facility in Toronto, Canada. Our lessons learned are organized into a practical guide made available in 2 different formats: this article and an illustrated peer-to-peer guide (http://www.baycrest.org/wp-content/uploads/HCE-PROG-HH_HighQuality.pdf). Copyright © 2017 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

CONSTRUCTION PROGRESS PHOTO SHOWING EMPLACEMENT STEEL BEAMS FUEL STORAGE BUILDING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

CONSTRUCTION PROGRESS PHOTO SHOWING EMPLACEMENT STEEL BEAMS FUEL STORAGE BUILDING (CPP-603) LOOKING EAST. INL PHOTO NUMBER NRTS-51-1371. Unknown Photographer, 1/31/1951 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

Emplacement history of a thrust sheet based on analysis of pressure solution cleavage and deformed fossils

DOE Office of Scientific and Technical Information (OSTI.GOV)

Protzman, G.M.; Mitra, G.

The emplacement history of a thrust sheet is recorded by the strain accumulated in its hanging wall and footwall. Detailed studies of second order structures and analysis of strain due to pressure solution and plastic deformation allow the authors to determine the deformation history of the Meade thrust in the Idaho - Wyoming thrust belt. Emplacement of the Meade thrust was accompanied by the formation of a series of second order in echelon folds in the footwall. Temporal relations based on detailed structural studies show that these folds, which are confined to the Jurassic Twin Creek Formation, formed progressively inmore » front of the advancing Meade thrust and were successively truncated and overridden by footwall imbricates of the Meade thrust. The Twin Creek Formation in both the hanging wall and footwall of the Meade thrust is penetratively deformed, with a well developed pressure solution cleavage. In addition, plastic strain is recorded by deformed Pentacrinus within fossil hash layers in the Twin Creek. Much of this penetrative deformation took place early in the history of the thrust sheet as layer parallel shortening, and the cleavage and deformed fossils behaved passively during subsequent folding and faulting. The later stages of deformation may be sequentially removed through balancing techniques to track successive steps in the deformation. This strain history, which is typical of an internal thrust sheet, is partly controlled by the lithologies involved, timing between successive thrusts, and the amount of interaction between major faults.« less

Magma emplacement in 3D

NASA Astrophysics Data System (ADS)

Gorczyk, W.; Vogt, K.

2017-12-01

Magma intrusion is a major material transfer process in Earth's continental crust. Yet, the mechanical behavior of the intruding magma and its host are a matter of debate. In this study, we present a series of numerical thermo-mechanical experiments on mafic magma emplacement in 3D.In our model, we place the magmatic source region (40 km diameter) at the base of the mantle lithosphere and connect it to the crust by a 3 km wide channel, which may have evolved at early stages of magmatism during rapid ascent of hot magmatic fluids/melts. Our results demonstrate continental crustal response due to magma intrusion. We observe change in intrusion geometries between dikes, cone-sheets, sills, plutons, ponds, funnels, finger-shaped and stock-like intrusions as well as injection time. The rheology and temperature of the host-rock are the main controlling factors in the transition between these different modes of intrusion. Viscous deformation in the warm and deep crust favours host rock displacement and magma pools along the crust-mantle boundary forming deep-seated plutons or magma ponds in the lower to middle-crust. Brittle deformation in the cool and shallow crust induces cone-shaped fractures in the host rock and enables emplacement of finger- or stock-like intrusions at shallow or intermediate depth. A combination of viscous and brittle deformation forms funnel-shaped intrusions in the middle-crust. Low-density source magma results in T-shaped intrusions in cross-section with magma sheets at the surface.

Relating Seismicity to Dike Emplacement, and the Conundrum of Dyke-Parallel Faulting

NASA Astrophysics Data System (ADS)

Dering, G.; Micklethwaite, S.; Cruden, A. R.; Barnes, S. J.; Fiorentini, M. L.

2016-12-01

Seismic monitoring shows that faulting and fracturing precede and accompany magma emplacement on timescales of hours and days. One outstanding problem is that the precision of earthquake hypocentre locations is typically limited to tens or hundreds of meters and cannot resolve whether the hypocentres relate to strain of wall rock fragments within the dikes, in a process zone around the intrusion or peripherally in the country rock. We examine a swarm of 19 dolerite dikes, near Albany, Western Australia using an unmanned aerial vehicle and Structure-from-Motion photogrammetry to obtain accurate, high resolution 3D reconstructions of outcrop and to digitally extract structural data. We find rare overprinting relationships indicate dike emplacement and faulting was coeval and that the number of faults/fractures increase into the dike swarm (2.2 ± 0.7 more fractures, per unit length in host rocks intruded by dikes relative to the background value). The faults are cataclasite-bearing and parallel to the dikes but intriguingly dike emplacement appears to have been accommodated by mode 1 extension. We further provide the first evidence that dike-parallel shear failure occurs in a damage zone associated with the dike swarm. These results support seismological observations of dike-parallel shear failure associated with some intrusion events, which contradict Mohr-Coulomb theory and numerical modelling of dike propagation in brittle-elastic rock, where shear failure is predicted to occur on faults oriented approximately 30° to the dyke plane. We suggest the dike swarm occupies a network of joints and fractures formed prior to swarm emplacement but then reactivated ahead of propagating dikes and remaining active during the early stages of emplacement.

Thermal Anomaly Engendered by the Emplacement of AN Au-DEPOSIT: Example from the Franciscan Complex

NASA Astrophysics Data System (ADS)

Lahfid, A.; Lacroix, B.; Delchini, S.; Hughes, J.

2016-12-01

The thermal history of the Lucia subterrane located within the Franciscan Complex (California, USA) has been previously proposed by Underwood et al. (1995). Based on both vitrinite reflectance (Rm) and illite cristallinity methods, these authors suggest that the Lucia subterrane is locally perturbed by a thermal anomaly (up to 300ºC), probably caused by the emplacement of an Au-deposit: the Los Burros Gold deposit. Although both the thermal anomaly and the deposit seem spatially correlated, their relationship is still poorly constrained. In order to better explain the anomalous temperatures recorded in the vicinity of the deposit and their possible link with mineralization processes, we first performed detailed geological and structural mapping within the Los Burros district coupled to a thermal study. The peak temperature reached by metasediments from the Lucia subterrane have been regionally investigated using Raman Spectroscopy of Carbonaceous Materials (RSCM) method. In addition, through a careful fluid-inclusion study of the deposit, the potential source and the temperature of the fluid responsible for the Los Burros Au-deposit emplacement are currently being investigated. Our preliminary results confirm the previous temperatures and the presence of the thermal anomaly in the range 260-320ºC as inferred by Underwood et al (1995). In addition, our structural interpretation shows that the Los Burros deposit was emplaced during a late tectonic event marked by local reorientation of the regional tectonic features and the emplacement of meter-wide, quartz-calcite-sulfide extension veins. The temperatures determined by both methods (RSCM thermometry and fluid inclusion microthermometry) are consistent and support that the thermal anomaly is likely generated by the emplacement of the Los Burros Au-deposit during a local tectonic event.

Magnetic fabric in granitoid plutons emplaced during Variscan orogeny and timing of their intrusions: Eastern Variscan front

NASA Astrophysics Data System (ADS)

Hrouda, F.; Schulmann, K.; Chlupacova, M.; Aichler, J.; Mixa, P.; Pecina, V.; Zacek, V.; Kroener, A.

2003-04-01

The eastern Variscan front at the Czech and Polish border is characterised by oblique underthrusting of Neo-Proterozoic continental margin below thickened crustal root. The underthrust plate is subsequently imbricated and forms obliquely convergent crustal wedge which was further thrust over the foreland. Several granitic plutons of arc geochemical affinity are intruded during different stages of crustal thickening and exhumation. Analysis of anisotropy of magnetic susceptibility was carried out to study the relationships between host rock deformation and magma emplacement fabrics in different crustal levels and geographical positions with respect to crustal wedge and westerly orogenic root. Deep seated granodiorite sheets (Javornik intrusion 348 Ma, and Stare Mesto sill 340 Ma) are emplaced in the deepest and more internal high grade parts of the orogen along the margin of thickened crustal root. They show AMS fabrics entirely concordant with surrounding high grade gneisses and were emplaced during contractional (transpressive) regime.The Sumperk granodiorite is a more shallow intrusion emplaced in the central part of the crustal wedge. This sheet-like intrusion shows its AMS fabrics conformable to transpressional fabrics of surrounding mylonitised barovian schists and gneisses. The Zulova Pluton 330 Ma, representing the shallowest intrusion, intrudes the most external part of the crustal wedge. It shows the magnetic fabrics virtually perpendicular to compressional structures in the neighbouring areas. In addition, these fabrics are clearly concordant with large-scale detachment zone along which the Devonian meta-sedimentary cover slided to the west. The AMS fabrics of granitoids thus testify the progressive oblique convergence prograding to the east followed by collapse of external part of orogenic wedge. The AMS fabric data allow us to evaluate the mechanical role of arc magmas syntectonically emplaced during oblique convergence and finally during normal shearing perpendicular to the orogen.

Paleomagnetic Investigations on the Tectonic Evolution of the Southeastern Anatolian Ophiolites in Late Cretaceous

NASA Astrophysics Data System (ADS)

Cengiz Cinku, M.; Karabulut, S.; Parlak, O.; Cabuk, B. S.; Ustaömer, T.; Hisarli, M. Z.

2016-12-01

Two E-W trending ophiolite belts crop out in SE Turkey, The southerly located ophiolites (Hatay, Koçali) were emplaced onto the Arabian Platform in Late Cretaceous whereas the northerly located ophiolites (Göksun, İspendere, Kömürhan, Guleman) were underthrust the S Tauride margin (i.e. Malatya-Keban Platform) in Late Cretaceous. Here we report our first paleomagnetic results from 155 different sites which was was focused on to the sheeted dyke complex, cumulate gabbros and extrusive sequences of each ophiolite from the N and S belts, while the cover units where sampled to distinguish emplacement related tectonic rotations from post-emplacement tectonic rotations. Rock magnetic experiments showed evidence of magnetite/titanomagnetite as the main magnetic carriers at the majority of sites. Progressive thermal and alternating demagnetization revealed that the characteristic remanent component is removed between 500 and 580 °C or 30-100 mT, respectively. Our new paleomagnetic results from the ophiolitic rocks emplaced in Arabian platform and the SE Anatolia show important implications to the spreading centre of the former ocean (s). Large counterclockwise rotations up to 100° are obtained from the sheeded dykes of the Hatay ophiolite in the Arabian plate with a paleolatitude of 16°, in contrast to the sheeded dykes of the Göksun ophiolite emplaced in the SE Anatolian with clockwise rotation of 90° and a paleolatitude of 22°. The relative movement of the ophiolitic series show their emplacement in the different zones. This study was financially supported by the project of the Scientific and Technical Research Council of Turkey (TUBITAK) with Project number 114R024.

Role of fluid in the mechanism of formation of volcaniclastic and coherent kimberlite facies: a diamond perspective

NASA Astrophysics Data System (ADS)

Fedortchouk, Yana; Chinn, Ingrid

2016-04-01

Dissolution features on diamonds recovered from kimberlites vary depending on the dissolution conditions and can be used as a reliable proxy for volatiles and their role in kimberlite emplacement. Volatiles determine the mechanism of magma emplacement; variation in volatile content and CO2/CO2+H2O ratio may affect the geology of kimberlite bodies and formation of coherent vs. volcaniclastic kimberlite facies. Here we examine the evolution of a kimberlite system during ascent using the resorption morphology of its diamond population. We use 655 macro-diamonds from a complex kimberlite pipe in the Orapa kimberlite field (Botswana) to examine the role of volatiles in the formation of the three facies comprising this pipe: two coherent kimberlite facies (CKA and CKB) and one massive volcaniclastic facies (MVK). The diamonds come from three drillholes through each of the studied kimberlite facies. Separate diamond samples derived from 2 - 13 m intervals were combined into 40 m depth intervals for statistical purposes. Four independent morphological methods allowed us to reliably discriminate products of resorption in kimberlite magma from resorption in the mantle, and use the former in our study. We found that the proportion of diamonds with kimberlitic resorption is the lowest in CKA - 22%, medium in MVK - 50%, and highest in CKB - 73%, and it increases with depth in each of the drillholes. Each kimberlite facies shows its own style of kimberlite-induced resorption on rounded tetrahexahedron (THH) diamonds: glossy surfaces in MVK, rough corroded surfaces in CKB, and combination of glossy surfaces with chains of circular pits in CKA, where these pits represent the initial stages of development of corrosive features observed on CKB diamonds. Based on the results of our previous experimental studies we propose that resorption of MVK diamonds is a product of interaction with COH fluid, resorption of CKB diamonds is a product of interaction with a volatile-undersaturated melt (possibly carbonatitic), and CKA diamonds show an overprint of melt-controlled resorption over a fluid-controlled resorption. We propose an early separation of the fluid phase during the ascent of this kimberlite magma, segregation of this fluid and rise towards the top of the magma column. Over-pressurisation caused by the expansion of this fluid worked as a driving force for the magma ascent acceleration. The magma column has separated into two parts: (1) the bubble-rich magma towards the top, explosive emplacement of which formed the MVK facies, followed by the "tailing" bubble-poor magma quietly arriving to form the CKA facies, and (2) magma that lost volatiles to the upwardly escaping bubbles, in which a slower ascent caused more intensive diamond resorption and delayed emplacement, forming the CKB facie. It is possible that formation, buoyancy, and growth of fluid bubbles controls the ascent of the kimberlite magma, where emplacement of bubble-rich magma forms volcaniclastic kimberlite facies, while fast rise of the bubbles through the magma column separates the fluid-rich phase that moves up preparing the conduit in the surrounding rocks and forms an explosive pipe at the surface, from a volatile-depleted magma, which slowly rises and fills the pipe with CK kimberlite facies.

Maximum Power Point tracking charge controllers for telecom applications -- Analysis and economics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wills, R.H.

Simple charge controllers connect photovoltaic modules directly to the battery bank resulting in a significant power loss if the battery bank voltage differs greatly from the PV Maximum Power Point (MPP) voltage. Recent modeling work at AES has shown that dc-dc converter type MPP tracking charge controllers can deliver more than 30% more energy from PV modules to the battery when the PV modules are cool and the battery state of charge is low--this is typically both the worst case condition (i.e., winter) and also the design condition that determines the PV array size. Economic modeling, based on typical telecommore » system installed costs shows benefits of more than $3/Wp for MPPT over conventional charge controllers in this application--a value that greatly exceeds the additional cost of the dc-dc converter.« less

CONSTRUCTION PROGRESS PHOTO REMOTE ANALYTICAL FACILITY (CPP627) SHOWING EMPLACEMENT OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

CONSTRUCTION PROGRESS PHOTO REMOTE ANALYTICAL FACILITY (CPP-627) SHOWING EMPLACEMENT OF ROOF SLABS. INL PHOTO NUMBER NRTS-54-13463. R.G. Larsen, Photographer, 12/20/1954 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

Multisensory Emplaced Learning: Resituating Situated Learning in a Moving World

ERIC Educational Resources Information Center

Fors, Vaike; Backstrom, Asa; Pink, Sarah

2013-01-01

This article outlines the implications of a theory of "sensory-emplaced learning" for understanding the interrelationships between the embodied and environmental in learning processes. Understanding learning as multisensory and contingent within everyday place-events, this framework analytically describes how people establish themselves as…