Prime the Pipeline Project (P[cube]): Putting Knowledge to Work

ERIC Educational Resources Information Center

Greenes, Carole; Wolfe, Susan; Weight, Stephanie; Cavanagh, Mary; Zehring, Julie

2011-01-01

With funding from NSF, the Prime the Pipeline Project (P[cube]) is responding to the need to strengthen the science, technology, engineering, and mathematics (STEM) pipeline from high school to college by developing and evaluating the scientific village strategy and the culture it creates. The scientific village, a community of high school…

77 FR 8724 - Natural Gas Pipelines; Project Cost and Annual Limits

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

...] Natural Gas Pipelines; Project Cost and Annual Limits February 9, 2012. AGENCY: Federal Energy Regulatory... limits for natural gas pipelines blanket construction certificates for each calendar year. DATES: This... CFR Part 157 Administrative practice and procedure, Natural gas, Reporting and recordkeeping...

76 FR 8293 - Natural Gas Pipelines; Project Cost and Annual Limits

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-14

...] Natural Gas Pipelines; Project Cost and Annual Limits February 8, 2011. AGENCY: Federal Energy Regulatory... for natural gas pipelines blanket construction certificates for each calendar year. DATES: Effective... of Subjects in 18 CFR Part 157 Administrative practice and procedure, Natural Gas, Reporting and...

A Caspase-Resistant Form of Bcl-XL, but Not Wild Type Bcl-XL, Promotes Clonogenic Survival After Ionizing Radiation

PubMed Central

Rehemtulla, Alnawaz; Hamilton, A Christin; Taneja, Neelam; Fridman, Jordan; Juan, Todd SC; Maybaum, Jonathan; Chinnaiyan, Arul

1999-01-01

Abstract Bcl-2 and Bcl-XL belong to a family of proteins overexpressed in a variety of human cancers which inhibit apoptosis in response to a number of stimuli including chemotherapeutic agents and ionizing radiation. To better understand the role of these polypeptides in modulating the response of cancer cells to ionizing radiation we used cell lines that were engineered to overexpress the two polypeptides. Although Bcl-2 and Bcl-XL overexpression resulted in inhibition of radiation-induced apoptosis, it did not result in enhanced clonogenic survival. Consistent with this was the observation that Bcl-2 and Bcl-XL protected cells from DNA fragmentation, loss of mitochondrial membrane potential, and caspase activation for up to 72 hours after irradiation. Beyond 72 hours, there was a rapid loss in the ability of Bcl-2 and Bcl-XL to inhibit these markers of apoptosis. When Bcl-XL was analyzed at 72 hours after irradiation and beyond, a rapid accumulation of a 16-kDa form of Bcl-XL was observed. To test the hypothesis that cleavage of the 29-kDa form of Bcl-XL by caspases to a 16-kDa polypeptide results in its inability to inhibit apoptosis beyond 72 hours, we constructed a cell line that overexpressed a caspase-resistant form of Bcl-XL Bcl-XLΔloop. Cells overexpressing Bcl-XL-Δloop were resistant to apoptosis beyond 72 hours after irradiation and did not contain the 16-kDa form at these time points. In addition, Bcl-XL-Δloop overexpression resulted in enhanced clonogenic survival compared with control or Bcl-XL overexpressing cells. These results provide a molecular basis for the observation that expression of Bcl-2 or Bcl-XL is not a prognostic marker of tumor response to cancer therapy. PMID:10935471

The Geysers pipeline project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dellinger, M.; Allen, E.

A unique public/private partnership of local, state, federal and corporate stakeholders are constructing the world`s first wastewater-to-electricity system at The Geysers. A rare example of a genuinely {open_quotes}sustainable{close_quotes} energy system, three Lake County communities will recycle their treated wastewater effluent through the southeast portion of the The Geysers steamfield to produce approximately 625,000 MWh annually from six existing geothermal power plants. In effect, the communities` effluent will produce enough power to indefinitely sustain their electric needs, along with enough extra power for thousands of other California consumers. Because of the project`s unique sponsorship, function and environmental impacts, its implementation hasmore » required: (1) preparation of a consolidated state environmental impact report (EIR) and federal environmental impact statement (EIS), and seven related environmental agreements and management plans; (2) acquisition of 25 local, state, and federal permits; (3) negotiation of six federal and state financial assistance agreements; (4) negotiation of six participant agreements on construction, operation and financing of the project, and (5) acquisition of 163 easements from private land owners for pipeline construction access and ongoing maintenance. The project`s success in efficiently and economically completing these requirements is a model for geothermal innovation and partnering throughout the Pacific Rim and elsewhere internationally.« less

The Minimal Preprocessing Pipelines for the Human Connectome Project

PubMed Central

Glasser, Matthew F.; Sotiropoulos, Stamatios N; Wilson, J Anthony; Coalson, Timothy S; Fischl, Bruce; Andersson, Jesper L; Xu, Junqian; Jbabdi, Saad; Webster, Matthew; Polimeni, Jonathan R; Van Essen, David C; Jenkinson, Mark

2013-01-01

The Human Connectome Project (HCP) faces the challenging task of bringing multiple magnetic resonance imaging (MRI) modalities together in a common automated preprocessing framework across a large cohort of subjects. The MRI data acquired by the HCP differ in many ways from data acquired on conventional 3 Tesla scanners and often require newly developed preprocessing methods. We describe the minimal preprocessing pipelines for structural, functional, and diffusion MRI that were developed by the HCP to accomplish many low level tasks, including spatial artifact/distortion removal, surface generation, cross-modal registration, and alignment to standard space. These pipelines are specially designed to capitalize on the high quality data offered by the HCP. The final standard space makes use of a recently introduced CIFTI file format and the associated grayordinates spatial coordinate system. This allows for combined cortical surface and subcortical volume analyses while reducing the storage and processing requirements for high spatial and temporal resolution data. Here, we provide the minimum image acquisition requirements for the HCP minimal preprocessing pipelines and additional advice for investigators interested in replicating the HCP’s acquisition protocols or using these pipelines. Finally, we discuss some potential future improvements for the pipelines. PMID:23668970

Italian river crossing; Horizontal drilling meets pipeline project criteria

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1988-06-01

The River Piave flows out of the Italian Alps, crossing the Veneto farmlands on its way to the Adriatic Sea. It is an important commerce-carrying waterway. SNAM, the Italian state gas pipeline company, wanted to install a 22-in. pipeline across the Piave just north of Venice. The method chosen for crossing the river had to meet several important criteria. InArc had used its river crossing method on seven previous SNAM projects and recommended the Piave crossing should be drilled. This paper describes the use of this horizontal drilling method for this application.

NetpathXL - An Excel Interface to the Program NETPATH

USGS Publications Warehouse

Parkhurst, David L.; Charlton, Scott R.

2008-01-01

NetpathXL is a revised version of NETPATH that runs under Windows? operating systems. NETPATH is a computer program that uses inverse geochemical modeling techniques to calculate net geochemical reactions that can account for changes in water composition between initial and final evolutionary waters in hydrologic systems. The inverse models also can account for the isotopic composition of waters and can be used to estimate radiocarbon ages of dissolved carbon in ground water. NETPATH relies on an auxiliary, database program, DB, to enter the chemical analyses and to perform speciation calculations that define total concentrations of elements, charge balance, and redox state of aqueous solutions that are then used in inverse modeling. Instead of DB, NetpathXL relies on Microsoft Excel? to enter the chemical analyses. The speciation calculation formerly included in DB is implemented within the program NetpathXL. A program DBXL can be used to translate files from the old DB format (.lon files) to NetpathXL spreadsheets, or to create new NetpathXL spreadsheets. Once users have a NetpathXL spreadsheet with the proper format, new spreadsheets can be generated by copying or saving NetpathXL spreadsheets. In addition, DBXL can convert NetpathXL spreadsheets to PHREEQC input files. New capabilities in PHREEQC (version 2.15) allow solution compositions to be written to a .lon file, and inverse models developed in PHREEQC to be written as NetpathXL .pat and model files. NetpathXL can open NetpathXL spreadsheets, NETPATH-format path files (.pat files), and NetpathXL-format path files (.pat files). Once the speciation calculations have been performed on a spreadsheet file or a .pat file has been opened, the NetpathXL calculation engine is identical to the original NETPATH. Development of models and viewing results in NetpathXL rely on keyboard entry as in NETPATH.

Montubi completes mile-long liquid ethylene pipeline project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1979-12-01

Montubi has completed the mile-long liquid ethylene pipeline project for Solvay S.p.A. at Vada, Italy, a line that extends 3.4 mi from an offshore unloading dock to an onshore gasification facility for Solvay's chemical plant at Rosignano. The 18 mo project included a mile-long 1750 ton jetty; one eight-leg main unloading platform; eight mooring dolphins plus four breasting dolphins; one small platform for firefighting pump units; and a concrete service road along the jetty.

78 FR 34091 - Sierrita Gas Pipeline LLC; Notice of Public Meeting for the Proposed Sierrita Pipeline Project

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-06

... Sierrita Pipeline Project right-of-way. The meeting is open to the public; however, the intent of the..., or on the FERC Web site at www.ferc.gov using the ``eLibrary'' link. Click on the eLibrary link...

Pegasus XL CYGNSS Rollout

NASA Image and Video Library

2016-11-28

At Vandenberg Air Force Base in California, an Orbital ATK Pegasus XL rocket is transported from the hangar at Building 1555 to be mated to L-1011 carrier aircraft near Vandenberg's runway. On board Pegasus are eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. When preparations are competed at Vandenberg, the L-1011/Pegasus XL combination will be flown to NASA’s Kennedy Space Center in Florida. On Dec. 12, 2016, the carrier aircraft is scheduled to take off from the Skid Strip at Cape Canaveral Air Force Station and CYGNSS will launch on the Pegasus XL rocket with the L-1011 flying off shore. CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

FutureGen 2.0 Pipeline and Regional Carbon Capture Storage Project - Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burger, Chris; Wortman, David; Brown, Chris

The U.S. Department of Energy’s (DOE) FutureGen 2.0 Program involves two projects: (1) the Oxy-Combustion Power Plant Project and (2) the CO2 Pipeline and Storage Project. This Final Technical Report is focused on the CO2 Pipeline and Storage Project. The FutureGen 2.0 CO2 Pipeline and Storage Project evolved from an initial siting and project definition effort in Phase I, into the Phase II activity consisting permitting, design development, the acquisition of land rights, facility design, and licensing and regulatory approvals. Phase II also progressed into construction packaging, construction procurement, and targeted early preparatory activities in the field. The CO2 Pipelinemore » and Storage Project accomplishments were significant, and in some cases unprecedented. The engineering, permitting, legal, stakeholder, and commercial learnings substantially advance the nation’s understanding of commercial-scale CO2 storage in deep saline aquifers. Voluminous and significant information was obtained from the drilling and the testing program of the subsurface, and sophisticated modeling was performed that held up to a wide range of scrutiny. All designs progressed to the point of securing construction contracts or comfort letters attesting to successful negotiation of all contract terms and willing execution at the appropriate time all major project elements – pipeline, surface facilities, and subsurface – as well as operations. While the physical installation of the planned facilities did not proceed in part due to insufficient time to complete the project prior to the expiration of federal funding, the project met significant objectives prior to DOE’s closeout decision. Had additional time been available, there were no known, insurmountable obstacles that would have precluded successful construction and operation of the project. Due to the suspension of the project, site restoration activities were developed and the work was accomplished. The site

Heat-induced fibrillation of BclXL apoptotic repressor.

PubMed

Bhat, Vikas; Olenick, Max B; Schuchardt, Brett J; Mikles, David C; Deegan, Brian J; McDonald, Caleb B; Seldeen, Kenneth L; Kurouski, Dmitry; Faridi, Mohd Hafeez; Shareef, Mohammed M; Gupta, Vineet; Lednev, Igor K; Farooq, Amjad

2013-09-01

The BclXL apoptotic repressor bears the propensity to associate into megadalton oligomers in solution, particularly under acidic pH. Herein, using various biophysical methods, we analyze the effect of temperature on the oligomerization of BclXL. Our data show that BclXL undergoes irreversible aggregation and assembles into highly-ordered rope-like homogeneous fibrils with length in the order of mm and a diameter in the μm-range under elevated temperatures. Remarkably, the formation of such fibrils correlates with the decay of a largely α-helical fold into a predominantly β-sheet architecture of BclXL in a manner akin to the formation of amyloid fibrils. Further interrogation reveals that while BclXL fibrils formed under elevated temperatures show no observable affinity toward BH3 ligands, they appear to be optimally primed for insertion into cardiolipin bicelles. This salient observation strongly argues that BclXL fibrils likely represent an on-pathway intermediate for insertion into mitochondrial outer membrane during the onset of apoptosis. Collectively, our study sheds light on the propensity of BclXL to form amyloid-like fibrils with important consequences on its mechanism of action in gauging the apoptotic fate of cells in health and disease. Copyright © 2013 Elsevier B.V. All rights reserved.

Pegasus XL CYGNSS Departure from VAFB

NASA Image and Video Library

2016-12-02

At Vandenberg Air Force Base in California, the Orbital ATK L-1011 Stargazer, with a Pegasus XL rocket mated to the underside of the aircraft, is prepared for takeoff. On board Pegasus XL are eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. When preparations are competed at Vandenberg, the /Pegasus XL combination will be flown to NASA’s Kennedy Space Center in Florida. On Dec. 12, 2016, the carrier aircraft is scheduled to take off from the Skid Strip at Cape Canaveral Air Force Station and CYGNSS will launch on the Pegasus XL rocket with the L-1011 flying off shore. CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will help scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a crucial role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Departure from VAFB

NASA Image and Video Library

2016-12-02

An Orbital ATK Pegasus XL rocket is mated to the underside of the company's L-1011 Stargazer aircraft. The Stargazer is being prepared for takeoff from Vandenberg Air Force Base in California. On board Pegasus XL are eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. When preparations are competed at Vandenberg, the /Pegasus XL combination will be flown to NASA’s Kennedy Space Center in Florida. On Dec. 12, 2016, the carrier aircraft is scheduled to take off from the Skid Strip at Cape Canaveral Air Force Station and CYGNSS will launch on the Pegasus XL rocket with the L-1011 flying off shore. CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will help scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a crucial role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Departure from VAFB

NASA Image and Video Library

2016-12-02

The Orbital ATK L-1011 Stargazer, with a Pegasus XL rocket mated to the underside of the aircraft, takes off at sunrise from Vandenberg Air Force Base in California. On board Pegasus XL are eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. The CYGNSS/Pegasus XL combination is being flown to NASA’s Kennedy Space Center in Florida. On Dec. 12, 2016, the carrier aircraft is scheduled to take off from the Skid Strip at Cape Canaveral Air Force Station and CYGNSS will launch on the Pegasus XL rocket with the L-1011 flying off shore. CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will help scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a crucial role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Departure from VAFB

NASA Image and Video Library

2016-12-02

The Orbital ATK L-1011 Stargazer, with a Pegasus XL rocket mated to the underside of the aircraft, has just taken off from Vandenberg Air Force Base in California. On board Pegasus XL are eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. The CYGNSS/Pegasus XL combination is being flown to NASA’s Kennedy Space Center in Florida. On Dec. 12, 2016, the carrier aircraft is scheduled to take off from the Skid Strip at Cape Canaveral Air Force Station and CYGNSS will launch on the Pegasus XL rocket with the L-1011 flying off shore. CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will help scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a crucial role in the beginning and intensification of hurricanes.

77 FR 66580 - Notice of Availability of the Record of Decision (ROD) for the Gulf Coast Pipeline Project

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-06

... subordinate its rights, acquired under the Wetland Reserve Program, to allow the Gulf Coast Segment (Gulf.... Department of State (DOS) to build and operate the Keystone XL Project. In the original application, Trans... built in three segments: The approximately 850-mile long ``Steele City'' segment from the U.S. border to...

Pegasus XL CYGNSS Fairing Installation

NASA Image and Video Library

2016-11-11

At Vandenberg Air Force Base in California, an Orbital ATK Pegasus XL rocket is seen during payload fairing installation in Building 1555. On board Pegasus are eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. When preparations are competed at Vandenberg, the L-1011/Pegasus XL combination will be flown to NASA’s Kennedy Space Center in Florida. On Dec. 12, 2016, the carrier aircraft is scheduled to take off from the Skid Strip at Cape Canaveral Air Force Station and CYGNSS will launch on the Pegasus XL rocket with the L-1011 flying off shore. CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will help scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a crucial role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Fairing Installation

NASA Image and Video Library

2016-11-11

In Building 1555 at Vandenberg Air Force Base in California, the payload fairing is being installed on an Orbital ATK Pegasus XL rocket. On board Pegasus are eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. When preparations are competed at Vandenberg, the L-1011/Pegasus XL combination will be flown to NASA’s Kennedy Space Center in Florida. On Dec. 12, 2016, the carrier aircraft is scheduled to take off from the Skid Strip at Cape Canaveral Air Force Station and CYGNSS will launch on the Pegasus XL rocket with the L-1011 flying off shore. CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will help scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a crucial role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Mate to L-1011

NASA Image and Video Library

2016-11-28

At Vandenberg Air Force Base in California, the Orbital ATK L-1011 Stargazer awaits a Pegasus XL rocket to be mated to the aircraft. On board Pegasus XL are eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. When preparations are competed at Vandenberg, the /Pegasus XL combination will be flown to NASA’s Kennedy Space Center in Florida. On Dec. 12, 2016, the carrier aircraft is scheduled to take off from the Skid Strip at Cape Canaveral Air Force Station and CYGNSS will launch on the Pegasus XL rocket with the L-1011 flying off shore. CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will help scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a crucial role in the beginning and intensification of hurricanes.

The developing human connectome project: A minimal processing pipeline for neonatal cortical surface reconstruction.

PubMed

Makropoulos, Antonios; Robinson, Emma C; Schuh, Andreas; Wright, Robert; Fitzgibbon, Sean; Bozek, Jelena; Counsell, Serena J; Steinweg, Johannes; Vecchiato, Katy; Passerat-Palmbach, Jonathan; Lenz, Gregor; Mortari, Filippo; Tenev, Tencho; Duff, Eugene P; Bastiani, Matteo; Cordero-Grande, Lucilio; Hughes, Emer; Tusor, Nora; Tournier, Jacques-Donald; Hutter, Jana; Price, Anthony N; Teixeira, Rui Pedro A G; Murgasova, Maria; Victor, Suresh; Kelly, Christopher; Rutherford, Mary A; Smith, Stephen M; Edwards, A David; Hajnal, Joseph V; Jenkinson, Mark; Rueckert, Daniel

2018-06-01

The Developing Human Connectome Project (dHCP) seeks to create the first 4-dimensional connectome of early life. Understanding this connectome in detail may provide insights into normal as well as abnormal patterns of brain development. Following established best practices adopted by the WU-MINN Human Connectome Project (HCP), and pioneered by FreeSurfer, the project utilises cortical surface-based processing pipelines. In this paper, we propose a fully automated processing pipeline for the structural Magnetic Resonance Imaging (MRI) of the developing neonatal brain. This proposed pipeline consists of a refined framework for cortical and sub-cortical volume segmentation, cortical surface extraction, and cortical surface inflation, which has been specifically designed to address considerable differences between adult and neonatal brains, as imaged using MRI. Using the proposed pipeline our results demonstrate that images collected from 465 subjects ranging from 28 to 45 weeks post-menstrual age (PMA) can be processed fully automatically; generating cortical surface models that are topologically correct, and correspond well with manual evaluations of tissue boundaries in 85% of cases. Results improve on state-of-the-art neonatal tissue segmentation models and significant errors were found in only 2% of cases, where these corresponded to subjects with high motion. Downstream, these surfaces will enhance comparisons of functional and diffusion MRI datasets, supporting the modelling of emerging patterns of brain connectivity. Copyright © 2018 Elsevier Inc. All rights reserved.

Automated processing pipeline for neonatal diffusion MRI in the developing Human Connectome Project.

PubMed

Bastiani, Matteo; Andersson, Jesper L R; Cordero-Grande, Lucilio; Murgasova, Maria; Hutter, Jana; Price, Anthony N; Makropoulos, Antonios; Fitzgibbon, Sean P; Hughes, Emer; Rueckert, Daniel; Victor, Suresh; Rutherford, Mary; Edwards, A David; Smith, Stephen M; Tournier, Jacques-Donald; Hajnal, Joseph V; Jbabdi, Saad; Sotiropoulos, Stamatios N

2018-05-28

The developing Human Connectome Project is set to create and make available to the scientific community a 4-dimensional map of functional and structural cerebral connectivity from 20 to 44 weeks post-menstrual age, to allow exploration of the genetic and environmental influences on brain development, and the relation between connectivity and neurocognitive function. A large set of multi-modal MRI data from fetuses and newborn infants is currently being acquired, along with genetic, clinical and developmental information. In this overview, we describe the neonatal diffusion MRI (dMRI) image processing pipeline and the structural connectivity aspect of the project. Neonatal dMRI data poses specific challenges, and standard analysis techniques used for adult data are not directly applicable. We have developed a processing pipeline that deals directly with neonatal-specific issues, such as severe motion and motion-related artefacts, small brain sizes, high brain water content and reduced anisotropy. This pipeline allows automated analysis of in-vivo dMRI data, probes tissue microstructure, reconstructs a number of major white matter tracts, and includes an automated quality control framework that identifies processing issues or inconsistencies. We here describe the pipeline and present an exemplar analysis of data from 140 infants imaged at 38-44 weeks post-menstrual age. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

F-16XL Ship #2 during last flight viewed from below showing shock fence on left wing

NASA Technical Reports Server (NTRS)

1996-01-01

A special 'shock fence' installed beneath the leading edge of the left wing is visible in this underside aerial view of NASA's F-16XL #2 research aircraft. The small structure assisted researchers in NASA's Supersonic Laminar Flow Control (SLFC) program in controlling the shock wave coming off the F-16XL's engine air inlet when the craft flew at speeds above Mach 1, or the speed of sound. The two-seat F-16XL, one of two 'XLs' flown by NASA's Drdyen Flight Research Center, Edwards, California, flew 45 missions comprising over 90 flight hours during the SLFC project, much of it at supersonic speeds up to Mach 2 and altitudes up to 55,000 feet. The project demonstrated that laminar -- or smooth -- airflow could be achieved over a major portion of a wing at supersonic speeds by use of a suction system. Data acquired during the program will be used to develop a design code calibration database which could assist designers in reducing aerodynamic drag of a proposed second-generation supersonic transport.

F-16XL Ship #2 during last flight showing titanium laminar flow glove on left wing

NASA Technical Reports Server (NTRS)

1996-01-01

The perforated titanium overlay mounted on the upper surface of the left wing is clearly evident on this view of NASA 848, a highly modified F-16XL aircraft flown by NASA's Dryden Flight Research Center in the Supersonic Laminar Flow Control (SLFC) research program. The two-seat, single-engine craft, one of only two 'XL' F-16s built, recently concluded the SLFC project with its 45th data collection mission. The project demonstrated that laminar--or smooth--airflow could be achieved over a major portion of a wing at supersonic speeds by use of a suction system. The system drew a small part of the boundary-layer air through millions of tiny laser-drilled holes in the 'glove' fitted to the upper left wing.

Handling Qualities Prediction of an F-16XL-Based Reduced Sonic Boom Aircraft

NASA Technical Reports Server (NTRS)

Cogan, Bruce; Yoo, Seung

2010-01-01

A major goal of the Supersonics Project under NASA s Fundamental Aeronautics program is sonic boom reduction of supersonic aircraft. An important part of this effort is development and validation of sonic boom prediction tools used in aircraft design. NASA Dryden s F- 16XL was selected as a potential testbed aircraft to provide flight validation. Part of this task was predicting the handling qualities of the modified aircraft. Due to the high cost of modifying the existing F-16XL control laws, it was desirable to find modifications that reduced the aircraft sonic boom but did not degrade baseline aircraft handling qualities allowing for the potential of flight test without changing the current control laws. This was not a requirement for the initial modification design work, but an important consideration for proceeding to the flight test option. The primary objective of this work was to determine an aerodynamic and mass properties envelope of the F-16XL aircraft. The designers could use this envelope to determine the effect of proposed modifications on aircraft handling qualities.

Bupropion XL-induced motor and vocal tics.

PubMed

Kayhan, Fatih; Uguz, Faruk; Kayhan, Ayşegül; Toktaş, Fikriye Ilay

2014-01-01

Tics are stereotypical repetitive involuntary movements (motor tics) or sounds (vocal tics). Although the emergence of tics were reported in a few cases with the use of selective serotonin reuptake inhibitors, there was no case with bupropion extended-release (Bupropion XL). The current case report presents a male patient developing motor and vocal tics with the use of bupropion XL.

76 FR 6612 - Lock+ Hydro Friends Fund XL; FFP Missouri 4, LLC; Allegheny 4 Hydro, LLC; Three Rivers Hydro, LLC...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-07

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 13746-000; Project No. 13750-000; Project No. 13776-000; Project No. 13782-000] Lock+ Hydro Friends Fund XL; FFP Missouri 4..., LLC--Project No. 13750-000 3. Allegheny 4 Hydro, LLC--Project No. 13776-000 4. Lock+ Hydro Friends...

Pegasus XL CYGNSS Fairing Mate Complete

NASA Image and Video Library

2016-11-15

In Building 1555 at Vandenberg Air Force Base in California, an Orbital ATK Pegasus XL rocket is seen after payload fairing installation. On board Pegasus are eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. When preparations are competed at Vandenberg, the L-1011/Pegasus XL combination will be flown to NASA’s Kennedy Space Center in Florida. On Dec. 12, 2016, the carrier aircraft is scheduled to take off from the Skid Strip at Cape Canaveral Air Force Station and CYGNSS will launch on the Pegasus XL rocket with the L-1011 flying off shore. CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will help scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a crucial role in the beginning and intensification of hurricanes.

Project Report: Active Pipeline Encroachment Detector (Phase I)

DOT National Transportation Integrated Search

2008-06-10

Of the many pipeline accident causes that occur to oil and gas pipelines, approximately 40% of are caused by third-party excavating activities into the buried pipeline right of way (ROW). According to DOT statistics, excavation damage is the second l...

Pegasus XL CYGNSS

NASA Image and Video Library

2016-09-15

Inside Building 1555 at Vandenberg Air Force Base in California, technicians and engineers install the first stage aft skirt on the Orbital ATK Pegasus XL rocket which will launch eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. When preparations are completed at Vandenberg, the rocket, with CYGNSS in its payload fairing, will be attached to the Orbital ATK L-1011 carrier aircraft and transported to NASA’s Kennedy Space Center in Florida. On Dec. 12, 2016, the carrier aircraft is scheduled to take off from the Skid Strip at Cape Canaveral Air Force Station and CYGNSS will launch on the Pegasus XL rocket with the L-1011 flying off shore. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Move to AIT

NASA Image and Video Library

2016-11-17

At Vandenberg Air Force Base in California, an Orbital ATK Pegasus XL rocket is placed on an assembly integration transporter for the move from the hangar at Building 1555 to be mated to L-1011 carrier aircraft near Vandenberg's runway. On board Pegasus are eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. When preparations are competed at Vandenberg, the L-1011/Pegasus XL combination will be flown to NASA’s Kennedy Space Center in Florida. On Dec. 12, 2016, the carrier aircraft is scheduled to take off from the Skid Strip at Cape Canaveral Air Force Station and CYGNSS will launch on the Pegasus XL rocket with the L-1011 flying off shore. CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Second Launch Attempt

NASA Image and Video Library

2016-12-15

An Orbital ATK L-1011 Stargazer aircraft carrying a Pegasus XL Rocket with eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, soars high after takeoff from the Skid Strip at Cape Canaveral Air Force Station, Florida. With the aircraft flying off shore, the Pegasus rocket will be released. Five seconds later, the solid propellant engine will ignite and boost the eight hurricane observatories to orbit. The eight CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. Release of the Pegasus XL rocket is scheduled for 8:40 a.m. EST.

Pegasus XL CYGNSS Second Launch Attempt

NASA Image and Video Library

2016-12-15

An Orbital ATK L-1011 Stargazer aircraft descends toward the Skid Strip at Cape Canaveral Air Force Station in Florida. The aircraft carried a Pegasus XL Rocket with eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, for launch. With the aircraft flying off shore, the Pegasus rocket was released. Five seconds later, the solid propellant engine ignited and boosted the eight hurricane observatories to orbit. The eight CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. Release of the Pegasus XL rocket occurred at 8:37 a.m. EST.

Pegasus XL CYGNSS - "Days to Launch" Sign

NASA Image and Video Library

2016-12-05

A sign just inside the gate to NASA's Kennedy Space Center in Florida notes that in seven days a Pegasus XL rocket is scheduled to launch with eight agency Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. On Dec. 12, 2016, the Orbital ATK L-1011 Stargazer, with a Pegasus XL rocket mated to the underside of the aircraft, will take off from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will launch on the Pegasus XL rocket with the L-1011 flying off shore. CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will help scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a crucial role in the beginning and intensification of hurricanes.

PAB3D Simulations for the CAWAPI F-16XL

NASA Technical Reports Server (NTRS)

Elmiligui, Alaa; Abdol-Hamid, K. S.; Massey, Steven J.

2007-01-01

Numerical simulations of the flow around F-16XL are performed as a contribution to the Cranked Arrow Wing Aerodynamic Project International (CAWAPI) using the PAB3D CFD code. Two turbulence models are used in the calculations: a standard k-! model, and the Shih-Zhu-Lumley (SZL) algebraic stress model. Seven flight conditions are simulated for the flow around the F-16XL where the free stream Mach number varies from 0.242 to 0.97. The range of angles of attack varies from 0deg to 20deg. Computational results, surface static pressure, boundary layer velocity profiles, and skin friction are presented and compared with flight data. Numerical results are generally in good agreement with flight data, considering that only one grid resolution is utilized for the different flight conditions simulated in this study. The ASM results are closer to the flight data than the k-! model results. The ASM predicted a stronger primary vortex, however, the origin of the vortex and footprint is approximately the same as in the k-! predictions.

Pipeline Expansions

EIA Publications

1999-01-01

This appendix examines the nature and type of proposed pipeline projects announced or approved for construction during the next several years in the United States. It also includes those projects in Canada and Mexico that tie-in with the U.S. markets or projects.

Pegasus XL CYGNSS Mate to L-1011

NASA Image and Video Library

2016-11-28

At Vandenberg Air Force Base in California, an Orbital ATK Pegasus XL rocket is transported to be mated to the company's L-1011 carrier aircraft near Vandenberg's runway. On board Pegasus are eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. When preparations are competed at Vandenberg, the L-1011/Pegasus XL combination will be flown to NASA’s Kennedy Space Center in Florida. On Dec. 12, 2016, the carrier aircraft is scheduled to take off from the Skid Strip at Cape Canaveral Air Force Station and CYGNSS will launch on the Pegasus XL rocket with the L-1011 flying off shore. CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Mate to L-1011

NASA Image and Video Library

2016-11-28

At Vandenberg Air Force Base in California, an Orbital ATK Pegasus XL rocket is mated to the company's L-1011 carrier aircraft near Vandenberg's runway. On board Pegasus are eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. When preparations are competed at Vandenberg, the L-1011/Pegasus XL combination will be flown to NASA’s Kennedy Space Center in Florida. On Dec. 12, 2016, the carrier aircraft is scheduled to take off from the Skid Strip at Cape Canaveral Air Force Station and CYGNSS will launch on the Pegasus XL rocket with the L-1011 flying off shore. CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Geohazard assessment lifecycle for a natural gas pipeline project

NASA Astrophysics Data System (ADS)

Lekkakis, D.; Boone, M. D.; Strassburger, E.; Li, Z.; Duffy, W. P.

2015-09-01

This paper is a walkthrough of the geohazard risk assessment performed for the Front End Engineering Design (FEED) of a planned large-diameter natural gas pipeline, extending from Eastern Europe to Western Asia for a total length of approximately 1,850 km. The geohazards discussed herein include liquefaction-induced pipe buoyancy, cyclic softening, lateral spreading, slope instability, groundwater rise-induced pipe buoyancy, and karst. The geohazard risk assessment lifecycle was comprised of 4 stages: initially a desktop study was carried out to describe the geologic setting along the alignment and to conduct a preliminary assessment of the geohazards. The development of a comprehensive Digital Terrain Model topography and aerial photography data were fundamental in this process. Subsequently, field geohazard mapping was conducted with the deployment of 8 teams of geoprofessionals, to investigate the proposed major reroutes and delve into areas of poor or questionable data. During the third stage, a geotechnical subsurface site investigation was then executed based on the results of the above study and mapping efforts in order to obtain sufficient data tailored for risk quantification. Lastly, all gathered and processed information was overlain into a Geographical Information database towards a final determination of the critical reaches of the pipeline alignment. Input from Subject Matter Experts (SME) in the fields of landslides, karst and fluvial geomorphology was incorporated during the second and fourth stages of the assessment. Their experience in that particular geographical region was key to making appropriate decisions based on engineering judgment. As the design evolved through the above stages, the pipeline corridor was narrowed from a 2-km wide corridor, to a 500-m corridor and finally to a fixed alignment. Where the geohazard risk was high, rerouting of the pipeline was generally selected as a mitigation measure. In some cases of high uncertainty in

U.S. pipeline industry enters new era

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnsen, M.R.

1999-11-01

The largest construction project in North America this year and next--the Alliance Pipeline--marks some advances for the US pipeline industry. With the Alliance Pipeline system (Alliance), mechanized welding and ultrasonic testing are making their debuts in the US as primary mainline construction techniques. Particularly in Canada and Europe, mechanized welding technology has been used for both onshore and offshore pipeline construction for at least 15 years. However, it has never before been used to build a cross-country pipeline in the US, although it has been tested on short segments. This time, however, an accelerated construction schedule, among other reasons, necessitatedmore » the use of mechanized gas metal arc welding (GMAW). The $3-billion pipeline will delivery natural gas from northwestern British Columbia and northeastern Alberta in Canada to a hub near Chicago, Ill., where it will connect to the North American pipeline grid. Once the pipeline is completed and buried, crews will return the topsoil. Corn and other crops will reclaim the land. While the casual passerby probably won't know the Alliance pipeline is there, it may have a far-reaching effect on the way mainline pipelines are built in the US. For even though mechanized welding and ultrasonic testing are being used for the first time in the United States on this project, some US workers had already gained experience with the technology on projects elsewhere. And work on this pipeline has certainly developed a much larger pool of experienced workers for industry to draw from. The Alliance project could well signal the start of a new era in US pipeline construction.« less

Lifesource XL-18 pedometer for measuring steps under controlled and free-living conditions.

PubMed

Liu, Sam; Brooks, Dina; Thomas, Scott; Eysenbach, Gunther; Nolan, Robert Peter

2015-01-01

The primary aim was to examine the criterion and construct validity and test-retest reliability of the Lifesource XL-18 pedometer (A&D Medical, Toronto, ON, Canada) for measuring steps under controlled and free-living activities. The influence of body mass index, waist size and walking speed on the criterion validity of XL-18 was also explored. Forty adults (35-74 years) performed a 6-min walk test in the controlled condition, and the criterion validity of XL-18 was assessed by comparing it to steps counted manually. Thirty-five adults participated in the free-living condition and the construct validity of XL-18 was assessed by comparing it to Yamax SW-200 (YAMAX Health & Sports, Inc., San Antonio, TX, USA). During the controlled condition, XL-18 did not significantly differ from criterion (P > 0.05) and no systematic error was found using Bland-Altman analysis. The accuracy of XL-18 decreased with slower walking speed (P = 0.001). During the free-living condition, Bland-Altman analysis revealed that XL-18 overestimated daily steps by 327 ± 118 than Yamax (P = 0.004). However, the absolute percent error (APE) (6.5 ± 0.58%) was still within an acceptable range. XL-18 did not differ statistically between pant pockets. XL-18 is suitable for measuring steps in controlled and free-living conditions. However, caution may be required when interpreting the steps recorded under slower speeds and free-living conditions.

F-16XL ship #1 crew

NASA Technical Reports Server (NTRS)

1995-01-01

November 27, 1995 Photograph of the F-16XL Ship #1 Cranked-Arrow Wing Aerodynamic Project (CAWAP) Test Team; from left to right, Ron Wilcox; Operations Engineer, Art Cope; Aircraft Mechanic, Dave Fisher; Chief Project Engineer, Dick Denman; Aircraft Mechanic, Bob Garcia; A/C Crew Chief, Susan Ligon; Aircraft Mechanic, Rodger Tarango; Mobile Operations Facility (MOF) Staff, Jerry Cousins; Aircraft Mechanic, Bruce Gallmeyer; MOF Staff, and Mike Reardon; Aircraft Mechanic/Helper. The modified airplane features a delta 'cranked-arrow' wing with strips of tubing along the leading edge to the trailing edge to sense static on the wing and obtain pressure distribution data. The right wing receives data on pressure distribution and the left wing has three types of instrumentation - preston tubes to measure local skin friction, boundary layer rakes to measure boundary layer profiles (the layer where the air interacts with the surfaces of a moving aircraft), and hot films to determine boundary layer transition locations. The first flight of CAWAP occurred at NASA's Dryden Flight Research Center, Edwards, California, on November 21, 1995, and the test program ended in April 1996.

77 FR 59393 - Jordan Cove Energy Project LP; Pacific Connector Gas Pipeline LP; Notice of Additional Public...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-27

...-17-000] Jordan Cove Energy Project LP; Pacific Connector Gas Pipeline LP; Notice of Additional Public..., and 11, 2012, the Federal Energy Regulatory Commission (FERC or Commission) Office of Energy Projects... additional public scoping meetings to take comments on Jordan Cove Energy Project LP's (Jordan Cove) proposed...

Natural Gas Pipeline and System Expansions

EIA Publications

1997-01-01

This special report examines recent expansions to the North American natural gas pipeline network and the nature and type of proposed pipeline projects announced or approved for construction during the next several years in the United States. It includes those projects in Canada and Mexico that tie in with U.S. markets or projects.

Pegasus XL CYGNSS Spacecraft Arrival

NASA Image and Video Library

2016-09-28

Parts for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) arrive in shipping containers and are stacked inside Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida in the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Spacecraft Arrival

NASA Image and Video Library

2016-09-28

Parts for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) arrive in a shipping container at Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida in the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Fairing Inspection

NASA Image and Video Library

2016-10-20

The payload fairing for an Orbital ATK Pegasus XL rocket is inspected in Building 1555 at Vandenberg Air Force Base in California. The fairing will protect NASA's Cyclone Global Navigation Satellite System (CYGNSS) spacecraft during launch. The rocket and spacecraft are being prepared at Vandenberg, then will be attached to the Orbital ATK L-1011 carrier aircraft and transported to NASA's Kennedy Space Center in Florida. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Spacecraft Arrival

NASA Image and Video Library

2016-09-28

Parts for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) arrive in shipping containers at Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida in the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

F-16XL Ship #2 during last flight showing titanium laminar flow glove on left wing

NASA Technical Reports Server (NTRS)

1996-01-01

Dryden research pilot Dana Purifoy bends NASA F-16 XL #848 away from the tanker on the 44th flight in the Supersonic Laminar Flow Control program recently. The flight test portion of the program ended with the 45th and last data collection flight from NASA's Dryden Flight Research Center, Edwards, California, on Nov. 26, 1996. The project demonstrated that laminar--or smooth--airflow could be achieved over a major portion of a wing at supersonic speeds. The flight tests at Dryden involved use of a suction system which drew boundary-layer air through millions of tiny laser-drilled holes in a titanium 'glove' that was fitted to the upper surface of the F-16XL's left wing.

Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis.

PubMed

Speir, Mary; Lawlor, Kate E; Glaser, Stefan P; Abraham, Gilu; Chow, Seong; Vogrin, Adam; Schulze, Keith E; Schuelein, Ralf; O'Reilly, Lorraine A; Mason, Kylie; Hartland, Elizabeth L; Lithgow, Trevor; Strasser, Andreas; Lessene, Guillaume; Huang, David C S; Vince, James E; Naderer, Thomas

2016-02-24

Human pathogenic Legionella replicate in alveolar macrophages and cause a potentially lethal form of pneumonia known as Legionnaires' disease(1). Here, we have identified a host-directed therapeutic approach to eliminate intracellular Legionella infections. We demonstrate that the genetic deletion, or pharmacological inhibition, of the host cell pro-survival protein BCL-XL induces intrinsic apoptosis of macrophages infected with virulent Legionella strains, thereby abrogating Legionella replication. BCL-XL is essential for the survival of Legionella-infected macrophages due to bacterial inhibition of host-cell protein synthesis, resulting in reduced levels of the short-lived, related BCL-2 pro-survival family member, MCL-1. Consequently, a single dose of a BCL-XL-targeted BH3-mimetic therapy, or myeloid cell-restricted deletion of BCL-XL, limits Legionella replication and prevents lethal lung infections in mice. These results indicate that repurposing BH3-mimetic compounds, originally developed to induce cancer cell apoptosis, may have efficacy in treating Legionnaires' and other diseases caused by intracellular microbes.

PipelineDog: a simple and flexible graphic pipeline construction and maintenance tool.

PubMed

Zhou, Anbo; Zhang, Yeting; Sun, Yazhou; Xing, Jinchuan

2018-05-01

Analysis pipelines are an essential part of bioinformatics research, and ad hoc pipelines are frequently created by researchers for prototyping and proof-of-concept purposes. However, most existing pipeline management system or workflow engines are too complex for rapid prototyping or learning the pipeline concept. A lightweight, user-friendly and flexible solution is thus desirable. In this study, we developed a new pipeline construction and maintenance tool, PipelineDog. This is a web-based integrated development environment with a modern web graphical user interface. It offers cross-platform compatibility, project management capabilities, code formatting and error checking functions and an online repository. It uses an easy-to-read/write script system that encourages code reuse. With the online repository, it also encourages sharing of pipelines, which enhances analysis reproducibility and accountability. For most users, PipelineDog requires no software installation. Overall, this web application provides a way to rapidly create and easily manage pipelines. PipelineDog web app is freely available at http://web.pipeline.dog. The command line version is available at http://www.npmjs.com/package/pipelinedog and online repository at http://repo.pipeline.dog. ysun@kean.edu or xing@biology.rutgers.edu or ysun@diagnoa.com. Supplementary data are available at Bioinformatics online.

Detached Eddy Simulation for the F-16XL Aircraft Configuration

NASA Technical Reports Server (NTRS)

Elmiligui, Alaa; Abdol-Hamid, Khaled; Parlette, Edward B.

2015-01-01

Numerical simulations for the flow around the F-16XL configuration as a contribution to the Cranked Arrow Wing Aerodynamic Project International 2 (CAWAPI-2) have been performed. The NASA Langley Tetrahedral Unstructured Software System (TetrUSS) with its USM3D solver was used to perform the unsteady flow field simulations for the subsonic high angle-of-attack case corresponding to flight condition (FC) 25. Two approaches were utilized to capture the unsteady vortex flow over the wing of the F-16XL. The first approach was to use Unsteady Reynolds-Averaged Navier-Stokes (URANS) coupled with standard turbulence closure models. The second approach was to use Detached Eddy Simulation (DES), which creates a hybrid model that attempts to combine the most favorable elements of URANS models and Large Eddy Simulation (LES). Computed surface static pressure profiles are presented and compared with flight data. Time-averaged and instantaneous results obtained on coarse, medium and fine grids are compared with the flight data. The intent of this study is to demonstrate that the DES module within the USM3D solver can be used to provide valuable data in predicting vortex-flow physics on a complex configuration.

Pegasus XL CYGNSS Fairing Arrival

NASA Image and Video Library

2016-10-11

Technicians with Orbital ATK move the first half of the Pegasus payload fairing for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) from into Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

A Synthesis of Hybrid RANS/LES CFD Results for F-16XL Aircraft Aerodynamics

NASA Technical Reports Server (NTRS)

Luckring, James M.; Park, Michael A.; Hitzel, Stephan M.; Jirasek, Adam; Lofthouse, Andrew J.; Morton, Scott A.; McDaniel, David R.; Rizzi, Arthur M.

2015-01-01

A synthesis is presented of recent numerical predictions for the F-16XL aircraft flow fields and aerodynamics. The computational results were all performed with hybrid RANS/LES formulations, with an emphasis on unsteady flows and subsequent aerodynamics, and results from five computational methods are included. The work was focused on one particular low-speed, high angle-of-attack flight test condition, and comparisons against flight-test data are included. This work represents the third coordinated effort using the F-16XL aircraft, and a unique flight-test data set, to advance our knowledge of slender airframe aerodynamics as well as our capability for predicting these aerodynamics with advanced CFD formulations. The prior efforts were identified as Cranked Arrow Wing Aerodynamics Project International, with the acronyms CAWAPI and CAWAPI-2. All information in this paper is in the public domain.

The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism.

PubMed

Zaanan, Aziz; Okamoto, Koichi; Kawakami, Hisato; Khazaie, Khashayarsha; Huang, Shengbing; Sinicrope, Frank A

2015-09-25

In colorectal cancers with oncogenic GTPase Kras (KRAS) mutations, inhibition of downstream MEK/ERK signaling has shown limited efficacy, in part because of failure to induce a robust apoptotic response. We studied the mechanism of apoptosis resistance in mutant KRAS cells and sought to enhance the efficacy of a KRAS-specific MEK/ERK inhibitor, GDC-0623. GDC-0623 was shown to potently up-regulate BIM expression to a greater extent versus other MEK inhibitors in isogenic KRAS HCT116 and mutant KRAS SW620 colon cancer cells. ERK silencing enhanced BIM up-regulation by GDC-0623 that was due to its loss of phosphorylation at Ser(69), confirmed by a BIM-EL phosphorylation-defective mutant (S69G) that increased protein stability and blocked BIM induction. Despite BIM and BIK induction, the isogenic KRAS mutant versus wild-type cells remained resistant to GDC-0623-induced apoptosis, in part because of up-regulation of BCL-XL. KRAS knockdown by a doxycycline-inducible shRNA attenuated BCL-XL expression. BCL-XL knockdown sensitized KRAS mutant cells to GDC-0623-mediated apoptosis, as did the BH3 mimetic ABT-263. GDC-0623 plus ABT-263 induced a synergistic apoptosis by a mechanism that includes release of BIM from its sequestration by BCL-XL. Furthermore, mutant KRAS activated p-STAT3 (Tyr(705)) in the absence of IL-6 secretion, and STAT3 knockdown reduced BCL-XL mRNA and protein expression. These data suggest that BCL-XL up-regulation by STAT3 contributes to mutant KRAS-mediated apoptosis resistance. Such resistance can be overcome by potent BIM induction and concurrent BCL-XL antagonism to enable a synergistic apoptotic response. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Pipelining in a changing competitive environment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, E.G.; Wishart, D.M.

1996-12-31

The changing competitive environment for the pipeline industry presents a broad spectrum of new challenges and opportunities: international cooperation; globalization of opportunities, organizations and competition; and integrated systems approach to system configuration, financing, contracting strategy, materials sourcing, and operations; cutting edge and emerging technologies; adherence to high standards of environmental protection; an emphasis on safety; innovative approaches to project financing; and advances in technology and programs to maintain the long term, cost effective integrity of operating pipeline systems. These challenges and opportunities are partially a result of the increasingly competitive nature of pipeline development and the public`s intolerance to incidentsmore » of pipeline failure. A creative systems approach to these challenges is often the key to the project moving ahead. This usually encompasses collaboration among users of the pipeline, pipeline owners and operators, international engineering and construction companies, equipment and materials suppliers, in-country engineers and constructors, international lending agencies and financial institutions.« less

Pegasus XL CYGNSS Spacecraft Mate

NASA Image and Video Library

2016-10-28

Inside Building 1555 at Vandenberg Air Force Base in California, the eight NASA Cyclone Global Navigation Satellite System (CYGNSS) spacecraft installed on their deployment module undergo inspections prior to NASA’s Kennedy Space Center in Florida. Processing activities will prepare the spacecraft for launch aboard an Orbital ATK Pegasus XL rocket. When preparations are competed at Vandenberg, the rocket will be transported to Kennedy attached to the Orbital ATK L-1011 carrier aircraft with in its payload fairing. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Fin Installation

NASA Image and Video Library

2016-09-21

Technicians prepare to install one of the fins on the Orbital ATK Pegasus XL rocket inside Building 1555 at Vandenberg Air Force Base in California. The fins will provide aerodynamic stability during flight. The rocket is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida, attached to the Orbital ATK L-1011 carrier aircraft with NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in its payload fairing. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Fin Installation

NASA Image and Video Library

2016-09-21

Technicians prepare one of the fins for installation on the Orbital ATK Pegasus XL rocket inside Building 1555 at Vandenberg Air Force Base in California. The fins will provide aerodynamic stability during flight. The rocket is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida, attached to the Orbital ATK L-1011 carrier aircraft with NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in its payload fairing. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Fin Installation

NASA Image and Video Library

2016-09-21

Technicians prepare to install one of the fins on the Orbital ATK Pegasus XL rocket inside Building 1555 at Vandenberg Air Force Base in California. The fins will provide aerodynamic stability during flight. The rocket is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida attached to the Orbital ATK L-1011 carrier aircraft with NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in its payload fairing. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Fairing Arrival

NASA Image and Video Library

2016-10-11

Technicians with Orbital ATK remove the first half of the Pegasus payload fairing for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) from its shipping container and prepare it for the move to nearby Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

F-16XL ship #1 CAWAP flight

NASA Technical Reports Server (NTRS)

1996-01-01

The single-seat F-16XL (ship #1) makes another run during the Cranked-Arrow Wing Aerodynamic Project (CAWAP) at Dryden Flight Research Center, Edwards, California. The modified airplane features a delta 'cranked-arrow' wing with strips of tubing along the leading edge to the trailing edge to sense static on the wing and obtain pressure distribution data. The right wing receives data on pressure distribution and the left wing has three types of instrumentation - preston tubes to measure local skin friction, boundary layer rakes to measure boundary layer profiles (the layer where the air interacts with the surfaces of a moving aircraft), and hot films to determine boundary layer transition locations. The first flight of CAWAP occurred on November 21, 1995, and the test program ended in April 1996.

ALMA Pipeline: Current Status

NASA Astrophysics Data System (ADS)

Shinnaga, H.; Humphreys, E.; Indebetouw, R.; Villard, E.; Kern, J.; Davis, L.; Miura, R. E.; Nakazato, T.; Sugimoto, K.; Kosugi, G.; Akiyama, E.; Muders, D.; Wyrowski, F.; Williams, S.; Lightfoot, J.; Kent, B.; Momjian, E.; Hunter, T.; ALMA Pipeline Team

2015-12-01

The ALMA Pipeline is the automated data reduction tool that runs on ALMA data. Current version of the ALMA pipeline produces science quality data products for standard interferometric observing modes up to calibration process. The ALMA Pipeline is comprised of (1) heuristics in the form of Python scripts that select the best processing parameters, and (2) contexts that are given for book-keeping purpose of data processes. The ALMA Pipeline produces a "weblog" that showcases detailed plots for users to judge how each step of calibration processes are treated. The ALMA Interferometric Pipeline was conditionally accepted in March 2014 by processing Cycle 0 and Cycle 1 data sets. From Cycle 2, ALMA Pipeline is used for ALMA data reduction and quality assurance for the projects whose observing modes are supported by the ALMA Pipeline. Pipeline tasks are available based on CASA version 4.2.2, and the first public pipeline release called CASA 4.2.2-pipe has been available since October 2014. One can reduce ALMA data both by CASA tasks as well as by pipeline tasks by using CASA version 4.2.2-pipe.

Pegasus XL CYGNSS Arrival at CCAFS

NASA Image and Video Library

2016-12-02

The Orbital ATK L-1011 Stargazer aircraft has arrived at the Skid Strip at Cape Canaveral Air Force Station in Florida. Attached beneath the Stargazer is the Orbital ATK Pegasus XL with NASA's Cyclone Global Navigation Satellite System (CYGNSS) on board. CYGNSS was processed and prepared for its mission at Vandenberg Air Force Base in California. CYGNSS is scheduled for its airborne launch aboard the Pegasus XL rocket from the Skid Strip on Dec. 12. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Arrival at CCAFS

NASA Image and Video Library

2016-12-02

The Orbital ATK L-1011 Stargazer aircraft begins its descent to the Skid Strip at Cape Canaveral Air Force Station in Florida. Attached beneath the Stargazer is the Orbital ATK Pegasus XL with NASA's Cyclone Global Navigation Satellite System (CYGNSS) on board. CYGNSS was processed and prepared for its mission at Vandenberg Air Force Base in California. CYGNSS is scheduled for its airborne launch aboard the Pegasus XL rocket from the Skid Strip on Dec. 12. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Fairing Mate and Black Light Test

NASA Image and Video Library

2016-11-14

Technicians with Orbital ATK perform a black light test on the Pegasus XL fairing inside Building 1555 at Vandenberg Air Force Base in California. NASA’s Cyclone Global Navigation Satellite System (CYGNSS) is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 Stargazer aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Fairing Mate and Black Light Test

NASA Image and Video Library

2016-11-14

Technicians with Orbital ATK install the first half of the Pegasus XL fairing around NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Expansion of the U.S. Natural Gas Pipeline Network

EIA Publications

2009-01-01

Additions in 2008 and Projects through 2011. This report examines new natural gas pipeline capacity added to the U.S. natural gas pipeline system during 2008. In addition, it discusses and analyzes proposed natural gas pipeline projects that may be developed between 2009 and 2011, and the market factors supporting these initiatives.

Pegasus XL CYGNSS Arrival at CCAFS

NASA Image and Video Library

2016-12-02

The Orbital ATK L-1011 Stargazer aircraft touches down at 3:57 p.m. EST at the Skid Strip at Cape Canaveral Air Force Station in Florida. Attached beneath the Stargazer is the Orbital ATK Pegasus XL with NASA's Cyclone Global Navigation Satellite System (CYGNSS) on board. CYGNSS was processed and prepared for its mission at Vandenberg Air Force Base in California. CYGNSS is scheduled for its airborne launch aboard the Pegasus XL rocket from the Skid Strip on Dec. 12. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Bp'S Baku-Tbilisi-Ceyhan pipeline: the new corporate colonialism.

PubMed

Marriott, James; Muttitt, Greg

2006-01-01

An international campaign was waged questioning the benefits of BP's Baku-Tbilisi-Ceyhan pipeline in an effort to avoid a "zone of sacrifice" there. This article is an offshoot of that effort and explains the contemporary struggle over the pipeline project. The authors describe the project's background and evaluate the actual and potential impacts of the project in which they consider eight areas. They also assess BP's capacity to confront resistance to the pipeline.

Orbital Sciences Pegasus XL Mate

NASA Image and Video Library

2007-02-28

At Vandenberg Air Force Base in California, the three stages of the Orbital Sciences Pegasus XL are being mated for the launch of NASA's Aeronomy of Ice in the Mesosphere, or AIM, spacecraft. AIM is the seventh Small Explorers mission under NASA's Explorer Program. The program provides frequent flight opportunities for world-class scientific investigations from space within heliophysics and astrophysics. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Pegasus XL CYGNSS Fairing Mate and Black Light Test

NASA Image and Video Library

2016-11-14

Technicians with Orbital ATK have installed the first half of the Pegasus XL fairing around NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. The second half of the fairing is being installed. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Fairing Mate and Black Light Test

NASA Image and Video Library

2016-11-14

Technicians with Orbital ATK have installed the first half of the Pegasus XL fairing around NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. Work is underway to install the second half of the fairing. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

75 FR 20265 - Airworthiness Directives; Liberty Aerospace Incorporated Model XL-2 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-19

... Airworthiness Directives; Liberty Aerospace Incorporated Model XL-2 Airplanes AGENCY: Federal Aviation...-08- 05, which applies to certain Liberty Aerospace Incorporated Model XL-2 airplanes. AD 2009-08-05...), the Director of the Federal Register approved the incorporation by reference of Liberty Aerospace, Inc...

F-16XL ship #1 CAWAP flight

NASA Technical Reports Server (NTRS)

1996-01-01

The single-seat F-16XL (ship #1) makes another run during the Cranked-Arrow Wing Aerodynamic Project (CAWAP) at Dryden Flight Research Center, Edwards, California. The modified airplane features a delta 'cranked-arrow' wing with strips of tubing along the leading edge to the trailing edge to sense static on the wing and obtain pressure distribution data. The right wing receives data on pressure distribution and the left wing has three types of instrumentation - preston tubes to measure local skin friction, boundary layer rakes to measure boundary layer profiles (the layer where the air interacts with the surfaces of a moving aircraft), and hot films to determine boundary layer transition locations. The program also gathered aero data on two wing planforms for NASA's High Speed Research Program. The first flight of CAWAP occurred on November 21, 1995, and the test program ended in April 1996.

Functional and physical interaction between Bcl-XL and a BH3-like domain in Beclin-1

PubMed Central

Maiuri, M Chiara; Le Toumelin, Gaëtane; Criollo, Alfredo; Rain, Jean-Christophe; Gautier, Fabien; Juin, Philippe; Tasdemir, Ezgi; Pierron, Gérard; Troulinaki, Kostoula; Tavernarakis, Nektarios; Hickman, John A; Geneste, Olivier; Kroemer, Guido

2007-01-01

The anti-apoptotic proteins Bcl-2 and Bcl-XL bind and inhibit Beclin-1, an essential mediator of autophagy. Here, we demonstrate that this interaction involves a BH3 domain within Beclin-1 (residues 114–123). The physical interaction between Beclin-1 and Bcl-XL is lost when the BH3 domain of Beclin-1 or the BH3 receptor domain of Bcl-XL is mutated. Mutation of the BH3 domain of Beclin-1 or of the BH3 receptor domain of Bcl-XL abolishes the Bcl-XL-mediated inhibition of autophagy triggered by Beclin-1. The pharmacological BH3 mimetic ABT737 competitively inhibits the interaction between Beclin-1 and Bcl-2/Bcl-XL, antagonizes autophagy inhibition by Bcl-2/Bcl-XL and hence stimulates autophagy. Knockout or knockdown of the BH3-only protein Bad reduces starvation-induced autophagy, whereas Bad overexpression induces autophagy in human cells. Gain-of-function mutation of the sole BH3-only protein from Caenorhabditis elegans, EGL-1, induces autophagy, while deletion of EGL-1 compromises starvation-induced autophagy. These results reveal a novel autophagy-stimulatory function of BH3-only proteins beyond their established role as apoptosis inducers. BH3-only proteins and pharmacological BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin-1 and Bcl-2 or Bcl-XL. PMID:17446862

Pan-Cancer Analysis Links PARK2 to BCL-XL-Dependent Control of Apoptosis.

PubMed

Gong, Yongxing; Schumacher, Steven E; Wu, Wei H; Tang, Fanying; Beroukhim, Rameen; Chan, Timothy A

2017-02-01

Mutation of the PARK2 gene can promote both Parkinson's Disease and cancer, yet the underlying mechanisms of how PARK2 controls cellular physiology is incompletely understood. Here, we show that the PARK2 tumor suppressor controls the apoptotic regulator BCL-XL and modulates programmed cell death. Analysis of approximately 10,000 tumor genomes uncovers a striking pattern of mutual exclusivity between PARK2 genetic loss and amplification of BCL2L1, implicating these genes in a common pathway. PARK2 directly binds to and ubiquitinates BCL-XL. Inactivation of PARK2 leads to aberrant accumulation of BCL-XL both in vitro and in vivo, and cancer-specific mutations in PARK2 abrogate the ability of the ubiquitin E3 ligase to target BCL-XL for degradation. Furthermore, PARK2 modulates mitochondrial depolarization and apoptosis in a BCL-XL-dependent manner. Thus, like genes at the nodal points of growth arrest pathways such as p53, the PARK2 tumor suppressor is able to exert its antiproliferative effects by regulating both cell cycle progression and programmed cell death. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Orbital Sciences Pegasus XL Mate

NASA Image and Video Library

2007-02-28

At Vandenberg Air Force Base in California, the second and third stages of the Orbital Sciences Pegasus XL rocket wait for mating. The rocket is the launch vehicle for the NASA's Aeronomy of Ice in the Mesosphere, or AIM, spacecraft. AIM is the seventh Small Explorers mission under NASA's Explorer Program. The program provides frequent flight opportunities for world-class scientific investigations from space within heliophysics and astrophysics. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL Mate

NASA Image and Video Library

2007-02-28

At Vandenberg Air Force Base in California, a technician on the work stand prepares the second stage of the Orbital Sciences Pegasus XL rocket to be mated to the first stage, at left, for the launch of NASA's Aeronomy of Ice in the Mesosphere, or AIM, spacecraft. AIM is the seventh Small Explorers mission under NASA's Explorer Program. The program provides frequent flight opportunities for world-class scientific investigations from space within heliophysics and astrophysics. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL Mate

NASA Image and Video Library

2007-02-28

At Vandenberg Air Force Base in California, a technician on the work stand prepares the first stage of the Orbital Sciences Pegasus XL rocket, at left, to be mated to the second stage, at right, for the launch of NASA's Aeronomy of Ice in the Mesosphere, or AIM, spacecraft. AIM is the seventh Small Explorers mission under NASA's Explorer Program. The program provides frequent flight opportunities for world-class scientific investigations from space within heliophysics and astrophysics. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL Mate

NASA Image and Video Library

2007-02-28

At Vandenberg Air Force Base in California, a technician on the work stand (center) prepares the second stage of the Orbital Sciences Pegasus XL rocket to be mated to the first stage, at left, for the launch of NASA's Aeronomy of Ice in the Mesosphere, or AIM, spacecraft. AIM is the seventh Small Explorers mission under NASA's Explorer Program. The program provides frequent flight opportunities for world-class scientific investigations from space within heliophysics and astrophysics. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL Mate

NASA Image and Video Library

2007-02-28

At Vandenberg Air Force Base in California, a technician checks the final step in mating of the first and second stages of the Orbital Sciences Pegasus XL rocket. The rocket is the launch vehicle for NASA's Aeronomy of Ice in the Mesosphere, or AIM, spacecraft. AIM is the seventh Small Explorers mission under NASA's Explorer Program. The program provides frequent flight opportunities for world-class scientific investigations from space within heliophysics and astrophysics. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL Mate

NASA Image and Video Library

2007-02-28

At Vandenberg Air Force Base in California, technicians discuss the process for mating the first and second stages of the Orbital Sciences Pegasus XL rocket in front of them. The rocket is the launch vehicle for NASA's Aeronomy of Ice in the Mesosphere, or AIM, spacecraft. AIM is the seventh Small Explorers mission under NASA's Explorer Program. The program provides frequent flight opportunities for world-class scientific investigations from space within heliophysics and astrophysics. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Differential subsidence and its effect on subsurface infrastructure: predicting probability of pipeline failure (STOOP project)

NASA Astrophysics Data System (ADS)

de Bruijn, Renée; Dabekaussen, Willem; Hijma, Marc; Wiersma, Ane; Abspoel-Bukman, Linda; Boeije, Remco; Courage, Wim; van der Geest, Johan; Hamburg, Marc; Harmsma, Edwin; Helmholt, Kristian; van den Heuvel, Frank; Kruse, Henk; Langius, Erik; Lazovik, Elena

2017-04-01

Due to heterogeneity of the subsurface in the delta environment of the Netherlands, differential subsidence over short distances results in tension and subsequent wear of subsurface infrastructure, such as water and gas pipelines. Due to uncertainties in the build-up of the subsurface, however, it is unknown where this problem is the most prominent. This is a problem for asset managers deciding when a pipeline needs replacement: damaged pipelines endanger security of supply and pose a significant threat to safety, yet premature replacement raises needless expenses. In both cases, costs - financial or other - are high. Therefore, an interdisciplinary research team of geotechnicians, geologists and Big Data engineers from research institutes TNO, Deltares and SkyGeo developed a stochastic model to predict differential subsidence and the probability of consequent pipeline failure on a (sub-)street level. In this project pipeline data from company databases is combined with a stochastic geological model and information on (historical) groundwater levels and overburden material. Probability of pipeline failure is modelled by a coupling with a subsidence model and two separate models on pipeline behaviour under stress, using a probabilistic approach. The total length of pipelines (approx. 200.000 km operational in the Netherlands) and the complexity of the model chain that is needed to calculate a chance of failure, results in large computational challenges, as it requires massive evaluation of possible scenarios to reach the required level of confidence. To cope with this, a scalable computational infrastructure has been developed, composing a model workflow in which components have a heterogeneous technological basis. Three pilot areas covering an urban, a rural and a mixed environment, characterised by different groundwater-management strategies and different overburden histories, are used to evaluate the differences in subsidence and uncertainties that come with

78 FR 39720 - Atmos Pipeline and Storage, LLC; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-02

... and Storage, LLC; Notice of Application Take notice that on June 14, 2013, Atmos Pipeline and Storage... authorizing the construction and operation of the Fort Necessity Gas Storage Project (Project) and associated...) \\2\\. \\1\\ Atmos Pipeline and Storage, LLC, 127 FERC ] 61,260 (2009). \\2\\ Atmos Pipeline and Storage...

The X-shooter pipeline

NASA Astrophysics Data System (ADS)

Goldoni, P.

2011-03-01

The X-shooter data reduction pipeline is an integral part of the X-shooter project, it allows the production of reduced data in physical quantities from the raw data produced by the instrument. The pipeline is based on the data reduction library developed by the X-shooter consortium with contributions from France, The Netherlands and ESO and it uses the Common Pipeline Library (CPL) developed at ESO. The pipeline has been developed for two main functions. The first function is to monitor the operation of the instrument through the reduction of the acquired data, both at Paranal, for a quick-look control, and in Garching, for a more thorough evaluation. The second function is to allow an optimized data reduction for a scientific user. In the following I will first outline the main steps of data reduction with the pipeline then I will briefly show two examples of optimization of the results for science reduction.

Pipeline enhances Norman Wells potential

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Approval of an oil pipeline from halfway down Canada's MacKenzie River Valley at Norman Wells to N. Alberta has raised the potential for development of large reserves along with controversy over native claims. The project involves 2 closely related proposals. One, by Esso Resources, the exploration and production unit of Imperial Oil, will increase oil production from the Norman Wells field from 3000 bpd currently to 25,000 bpd. The other proposal, by Interprovincial Pipeline (N.W) Ltd., calls for construction of an underground pipeline to transport the additional production from Norman Wells to Alberta. The 560-mile, 12-in. pipeline will extend frommore » Norman Wells, which is 90 miles south of the Arctic Circle on the north shore of the Mackenzie River, south to the end of an existing line at Zama in N. Alberta. There will be 3 pumping stations en route. This work also discusses recovery, potential, drilling limitations, the processing plant, positive impact, and further development of the Norman Wells project.« less

Bcl-XL small interfering RNA suppresses the proliferation of 5-fluorouracil-resistant human colon cancer cells.

PubMed

Zhu, Hongbo; Guo, Wei; Zhang, Lidong; Davis, John J; Teraishi, Fuminori; Wu, Shuhong; Cao, Xiaobo; Daniel, Jonathan; Smythe, W Roy; Fang, Bingliang

2005-03-01

5-Fluorouracil (5-FU) is commonly used to treat human colon cancers but resistance to this compound is frequently observed in clinics. To characterize mechanisms of resistance to 5-FU and to develop new strategies for overcoming it, we established two cell lines that were resistant to 5-FU but not other chemotherapeutic agents from parental 5-FU-sensitive cell lines. Western blot analysis revealed that these resistant cells overexpressed the proteins Bcl-XL, Bcl-Xs, and Bik, and further data showed that the cells were resistant to 5-FU-induced DNA damage and cell cycle disorder. However, in parental cells, enforced expression of Bcl-XL protein provided only limited protection from 5-FU-induced apoptosis and overexpression of Bcl-XL protein did not affect 5-FU-induced DNA damage or cell cycle changes; these findings suggested that overexpression of Bcl-XL protein was not the major contributor to 5-FU resistance in any of our cells lines. Even so, knockdown of Bcl-XL protein expression by Bcl-XL-specific small interfering RNA could inhibit proliferation more effectively in 5-FU-resistant cells than in 5-FU-sensitive cells, and the combination of Bcl-XL-specific small interfering RNA and 5-FU had additive effect on the inhibition of 5-FU-resistant cells. These results suggest that down-regulation of Bcl-XL protein expression might provide a new treatment strategy for human 5-FU-resistant colon cancer therapy.

Pipelined CPU Design with FPGA in Teaching Computer Architecture

ERIC Educational Resources Information Center

Lee, Jong Hyuk; Lee, Seung Eun; Yu, Heon Chang; Suh, Taeweon

2012-01-01

This paper presents a pipelined CPU design project with a field programmable gate array (FPGA) system in a computer architecture course. The class project is a five-stage pipelined 32-bit MIPS design with experiments on the Altera DE2 board. For proper scheduling, milestones were set every one or two weeks to help students complete the project on…

F-16XL ship #1 outboard rake #7

NASA Technical Reports Server (NTRS)

1996-01-01

This photo shows the #7 outboard rake on the left wing of NASA's single-seat F-16XL (ship #1) used for the Cranked-Arrow Wing Aerodynamic Project (CAWAP) at Dryden Flight Research Center, Edwards, California. The modified airplane features a delta 'cranked-arrow' wing with strips of tubing along the leading edge to the trailing edge to sense static on the wing and obtain pressure distribution data. The right wing receives data on pressure distribution and the left wing has three types of instrumentation - preston tubes to measure local skin friction, boundary layer rakes to measure boundary layer profiles (the layer where the air interacts with the surfaces of a moving aircraft), and hot films to determine boundary layer transition locations. The first flight of CAWAP occurred on November 21, 1995, and the test program ended in April 1996.

Pegasus XL CYGNSS Final Wing Installation

NASA Image and Video Library

2016-09-28

Inside Building 1555 at Vandenberg Air Force Base in California, technicians and engineers perform final wing installations on the Orbital ATK Pegasus XL rocket which will launch eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. When preparations are completed at Vandenberg, the rocket, with CYGNSS in its payload fairing, will be attached to the Orbital ATK L-1011 carrier aircraft and transported to NASA’s Kennedy Space Center in Florida. On Dec. 12, 2016, the carrier aircraft is scheduled to take off from the Skid Strip at Cape Canaveral Air Force Station and CYGNSS will launch on the Pegasus XL rocket with the L-1011 flying off shore. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Orbital Sciences Pegasus XL Flight Simulation

NASA Image and Video Library

2007-02-28

At Vandenberg Air Force Base in California, the Orbital Sciences Pegasus XL rocket undergoes its second flight simulation. The rocket is the launch vehicle for NASA's Aeronomy of Ice in the Mesosphere, or AIM, spacecraft. AIM is the seventh Small Explorers mission under NASA's Explorer Program. The program provides frequent flight opportunities for world-class scientific investigations from space within heliophysics and astrophysics. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL Flight Simulation

NASA Image and Video Library

2007-02-28

At Vandenberg Air Force Base in California, a worker monitors the Orbital Sciences Pegasus XL rocket after a second flight simulation. The rocket is the launch vehicle for NASA's Aeronomy of Ice in the Mesosphere, or AIM, spacecraft. AIM is the seventh Small Explorers mission under NASA's Explorer Program. The program provides frequent flight opportunities for world-class scientific investigations from space within heliophysics and astrophysics. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Project #153M: Guidance for Assessing the Remaining Strength of Corroded Pipelines

DOT National Transportation Integrated Search

2010-04-01

Incident statistics have consistently shown that corrosion is the primary cause of pipeline failures in liquid pipelines, and is the second largest cause of failures in natural gas transmission pipelines and distribution piping. Corrosion can cause m...

F-16XL Ship #1 in flight - used for laminar airflow studies

NASA Technical Reports Server (NTRS)

1992-01-01

One of two F-16XL prototype aircraft, on loan from the Air Force, was used by NASA's Dryden Flight Research Center, Edwards, California, in a program to investigate laminar flow technology and help improve the flow of air over an aircraft's wing at sustained supersonic speeds. A small, perforated titanium wing glove with a turbo compressor was tested on the F-16XL to determine if air suction can remove a small part of the boundary-layer air flowing over the wing and thereby achieve laminar (smooth) flow over a portion of the wing. The flight research program on ship #1 ended in 1996. It was then conducted with NASA's two-seat F-16XL, ship #2 employing a larger glove.

Active matrix organic light emitting diode (OLED)-XL life test results

NASA Astrophysics Data System (ADS)

Fellowes, David A.; Wood, Michael V.; Hastings, Arthur R., Jr.; Ghosh, Amalkumar P.; Prache, Olivier

2008-04-01

OLED displays have been known to exhibit high levels of performance with regards to contrast, response time, uniformity, and viewing angle, but a lifetime improvement has been perceived to be essential for broadening the applications of OLED's in the military and in the commercial market. As a result of this need, the US Army and eMagin Corporation established a Cooperative Research and Development Agreement (CRADA) to improve the lifetime of OLED displays. In 2006, eMagin Corporation developed long-life OLED-XL devices for use in their AMOLED microdisplays for head-worn applications, and RDECOM CERDEC NVESD ran life tests on these displays, finding over 200% lifetime improvement for the XL devices over the standard displays. Early results were published at the 2007 SPIE Defense and Security Symposium. Further life testing of XL and standard devices at ambient conditions and at high temperatures will be presented this year along with a recap of previous data. This should result in a better understanding of the applicability of AMOLEDs in military and commercial head mounted systems: where good fits are made, and where further development might be needed. This is a continuation of the paper "Life test results of OLED-XL long-life devices for use in active matrix organic light emitting diode (AMOLED) displays for head mounted applications" presented at SPIE DSS in 2007.

Pipeline perspective

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kern, J.J.

1978-01-01

The recently completed 800-mile trans-Alaska pipeline is reviewed from the perspective of its first six months of successful operation. Because of the many environmental and political constraints, the $7.7 billion project is viewed as a triumph of both engineering and capitalism. Design problems were imposed by the harsh climate and terrain and by the constant public and bureaucratic monitoring. Specifications are reviewed for the pipes, valves, river crossings, pump stations, control stations, and the terminal at Valdez, where special ballast treatment and a vapor-recovery system were required to protect the harbor's water and air quality. The article outlines operating proceduresmore » and contingency planning for the pipeline and terminal. (DCK)« less

Orbital Sciences Pegasus XL Flight Simulation

NASA Image and Video Library

2007-02-28

Seen at Vandenberg Air Force Base in California is the fairing (foreground) for the Orbital Sciences Pegasus XL rocket. In the background is the third stage, under the clean room tent. The rocket is the launch vehicle for NASA's Aeronomy of Ice in the Mesosphere, or AIM, spacecraft. AIM is the seventh Small Explorers mission under NASA's Explorer Program. The program provides frequent flight opportunities for world-class scientific investigations from space within heliophysics and astrophysics. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL Flight Simulation

NASA Image and Video Library

2007-02-28

At Vandenberg Air Force Base in California, workers monitor the data produced by the second flight simulation of the Orbital Sciences Pegasus XL rocket. The rocket is the launch vehicle for NASA's Aeronomy of Ice in the Mesosphere, or AIM, spacecraft. AIM is the seventh Small Explorers mission under NASA's Explorer Program. The program provides frequent flight opportunities for world-class scientific investigations from space within heliophysics and astrophysics. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL Flight Simulation

NASA Image and Video Library

2007-02-28

At Vandenberg Air Force Base in California, a worker monitors the data produced by the second flight simulation of the Orbital Sciences Pegasus XL rocket. The rocket is the launch vehicle for NASA's Aeronomy of Ice in the Mesosphere, or AIM, spacecraft. AIM is the seventh Small Explorers mission under NASA's Explorer Program. The program provides frequent flight opportunities for world-class scientific investigations from space within heliophysics and astrophysics. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

The Mechanical Property Data Base from an Air Force/Industry Cooperative Test Program on Advanced Aluminum Alloys (IN905XL and AL905XL Forgings)

DTIC Science & Technology

1991-12-01

850F FOR 2 HRS STEP 2 - 665F FOR 2 HRS STEP 3 - WARM WATER QUENCH STEP 4 - 230F FOR 24 HRS TABLE G5 TENSILE RESULTS FOR IN905XL FORGING COMPANY TEST...HRS STEP 2 - 665F FOR 2 HRS STEP 3 - WARM WATER QUENCH STEP 4 - 230F FOR 24 HRS 12 TABLE G6 COMPRESSION RESULTS FOR IN905XL FORGING COMPANY TEST...LONG 58.0 11.4 DYNAMICS (*) (*): HEAT TREATED TO THE FOLLOWING SCHEDULE: STEP 1 - 850F FOR 2 HRS STEP 2 - 665F FOR 2 HRS STEP 3 - WARM WATER QUENCH

Flight Test Results for the F-16XL With a Digital Flight Control System

NASA Technical Reports Server (NTRS)

Stachowiak, Susan J.; Bosworth, John T.

2004-01-01

In the early 1980s, two F-16 airplanes were modified to extend the fuselage length and incorporate a large area delta wing planform. These two airplanes, designated the F-16XL, were designed by the General Dynamics Corporation (now Lockheed Martin Tactical Aircraft Systems) (Fort Worth, Texas) and were prototypes for a derivative fighter evaluation program conducted by the United States Air Force. Although the concept was never put into production, the F-16XL prototypes provided a unique planform for testing concepts in support of future high-speed supersonic transport aircraft. To extend the capabilities of this testbed vehicle the F-16XL ship 1 aircraft was upgraded with a digital flight control system. The added flexibility of a digital flight control system increases the versatility of this airplane as a testbed for aerodynamic research and investigation of advanced technologies. This report presents the handling qualities flight test results covering the envelope expansion of the F-16XL with the digital flight control system.

Toward Improved Predictions of Slender Airframe Aerodynamics Using the F-16XL Aircraft

NASA Technical Reports Server (NTRS)

Luckring, James M.; Rizzi, Arthur; Davis, M. Bruce

2016-01-01

A coordinated project has been underway to improve computational fluid dynamics predictions of slender airframe aerodynamics. The work is focused on two flow conditions and leverages a unique flight data set obtained with an F-16XL aircraft. These conditions, a low-speed high angle-of-attack case and a transonic low angle-of-attack case, were selected from a prior prediction campaign wherein the computational fluid dynamics failed to provide acceptable results. In this paper, the background, objectives, and approach to the current project are presented. The work embodies predictions from multiple numerical formulations that are contributed from multiple organizations, and the context of this campaign to other multicode, multi-organizational efforts is included. The relevance of this body of work toward future supersonic commercial transport concepts is also briefly addressed.

77 FR 21763 - Explorer Pipeline Company; Notice of Petition for Declaratory Order

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-11

... pipeline extension project (Diluent Extension Project). The Diluent Extension Project involves the... Rule 207(a)(2) of the Commission's Rules of Practice and Procedure, 18 CFR 385.207(a)(2)(2011), Explorer Pipeline Company (Explorer) petitioned the Federal Energy Regulatory Commission for a declaratory...

BAX/BCL-XL gene expression ratio inversely correlates with disease progression in chronic myeloid leukemia.

PubMed

Gonzalez, Mariana S; De Brasi, Carlos D; Bianchini, Michele; Gargallo, Patricia; Moiraghi, Beatriz; Bengió, Raquel; Larripa, Irene B

2010-10-15

BCR-ABL fusion gene is implicated in the pathogenesis of chronic myeloid leukemia (CML), encoding the oncoprotein p210(BCR-ABL) with anti-apoptotic activity. The inability to undergo apoptosis is an important mechanism of drug resistance and neoplastic evolution in CML. The gene transcript expression of mitochondrial apoptotic related genes BAX and BCL-XL was evaluated by quantitative Real Time PCR (qPCR) in vitro in K562 cells and in vivo in peripheral blood of 66 CML patients in different stages of the disease: 13 cases at diagnosis, 34 in chronic phase (CP), 10 in accelerated phase (AP) and 9 in blast crisis (BC). Our results in K562 cells showed that all treatments with different tyrosine kinase inhibitors (TKIs) induced a decreased expression of the antiapoptotic oncogene BCL-XL, whereas the proapoptotic gene BAX remains constant with minor modifications. A significantly lower BAX/BCL-XL expression ratio (mean±SEM) than a group of healthy individuals (4.8±0.59) were observed in CML patients at diagnosis (1.28 ± 0.16), in AP (1.14±0.20), in BC (1.16±0.30) and in 18% of cases of patients in CP (2.71±0.40). Most CP cases (82%) showed a significantly increased ratio (10.03±1.30), indicating that the treatment with TKIs efficiently inhibited the expression of BCL-XL by blocking BCR-ABL oncoprotein. The BAX/BCL-XL ratio showed a significant inverse correlation (Spearman P<0.0001) with BCR-ABL/ABL relative expression indicating that low BAX/BCL-XL was associated with disease progression. Accordingly, the follow up of a cohort of eight cases during 6months from diagnosis showed that while the BAX/BCL-XL ratio rapidly increased after treatment in seven cases with good evolution, it decreased in the single case that showed rapid evolution and short survival. Our data suggest that BAX/BCL-XL expression ratio may be a sensitive monitor of disease progression and an early predictor of TKI therapy responsiveness in CML patients. Copyright © 2010 Elsevier Inc. All

Up-Regulation of Bcl-xl by Hepatocyte Growth Factor in Human Mesothelioma Cells Involves ETS Transcription Factors

PubMed Central

Cao, Xiaobo; Littlejohn, James; Rodarte, Charles; Zhang, Lidong; Martino, Benjamin; Rascoe, Philip; Hamid, Kamran; Jupiter, Daniel; Smythe, W. Roy

2009-01-01

Bcl-xl and the hepatocyte growth factor (HGF) receptor c-Met are both highly expressed in mesotheliomas, where they protect cells from apoptosis and can confer resistance to conventional therapeutic agents. In our current study, we investigate a model for the transcriptional control of Bcl-xl that involves ETS transcription factors and the HGF/Met axis. In addition, the effects of activated c-Met on the phosphorylation of the ETS family transcriptional factors were examined. The transient expression of ETS-2 and PU.1 cDNAs in mesothelioma cell lines resulted in an increase in the promoter activity of Bcl-xl and consequently in its mRNA and protein expression levels, whereas the transcriptional repressor Tel suppressed Bcl-xl transcription. The activation of the HGF/Met axis led to rapid phosphorylation of ETS family transcription factors in mesothelioma cells through the mitogen-activated protein kinase pathway and via nuclear accumulation of ETS-2 and PU.1. A chromatin immunoprecipitation assay further demonstrated that the activation of c-Met enhanced the binding of ETS transcriptional factors to the Bcl-x promoter. Finally, we determined the Bcl-xl and phosphorylated c-Met expression levels in mesothelioma patient samples; these data suggest a strong correlation between Bcl-xl and phosphorylated c-Met levels. Taken together, these findings support a role for c-Met as an inhibitor of apoptosis and an activator of Bcl-xl. PMID:19834061

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-11

Inside Building 1555 at Vandenberg Air Force Base in California, one of eight NASA Cyclone Global Navigation Satellite System (CYGNSS) spacecraft is inspected. Processing activities will prepare the spacecraft for launch aboard an Orbital ATK Pegasus XL rocket. When preparations are competed at Vandenberg, the rocket will be transported to NASA’s Kennedy Space Center in Florida attached to the Orbital ATK L-1011 carrier aircraft with in its payload fairing. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-11

Technicians with Orbital ATK prepare to install the micro satellites on the deployment module for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-12

A technician with Orbital ATK prepares to install another micro satellite on the deployment module for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-11

Technicians with Orbital ATK install the first two sets of micro satellites on the deployment module for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-11

A technician with Orbital ATK prepares the deployment module for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) for micro satellites installation in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-11

A technician with Orbital ATK checks out the micro satellites deployment module for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-13

All of the micro satellites have been fully installed on the deployment module by Orbital ATK for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-11

Technicians with Orbital ATK prepare the micro satellites for installation on the deployment module for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-12

Technicians with Orbital ATK continue to install the micro satellites on the deployment module for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-12

Technicians with Orbital ATK continue to install micro satellites on the deployment module for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-11

A technician with Orbital ATK assembles the micro satellites deployment module for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-11

Technicians with Orbital ATK check assemble the micro satellites deployment module for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-11

Technicians with Orbital ATK prepare a set of micro satellites for installation on the deployment module for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-11

Technicians with Orbital ATK check out the micro satellites deployment module for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-11

Technicians with Orbital ATK prepare to install micro satellites on the deployment module for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-12

A technician with Orbital ATK checks the installation of the micro satellites on the deployment module for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-11

Technicians with Orbital ATK install the first set of micro satellites on the deployment module for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-11

A technician with Orbital ATK prepares a set of micro satellites for installation on the deployment module for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

77 FR 29624 - Cheniere Creole Trail Pipeline, L.P.; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-18

... Creole Trail Pipeline, L.P.; Notice of Application Take notice that on April 30, 2012, Cheniere Creole Trail Pipeline, L.P. (Cheniere), 700 Milam, Suite 800, Houston, TX 77002, filed an application in Docket... Creole Trail Expansion Project (Project). Cheniere's Project would consist of construction of a new 53...

Dirty Oil and Shovel-Ready Jobs

ERIC Educational Resources Information Center

Mac Phail, Abby

2012-01-01

In this article, the author describes a role-playing activity on tar sands and the proposed TransCanada Keystone XL pipeline. In this activity, students take on the characters of six key stakeholders invited to an imaginary public hearing to discuss whether or not the State Department and President Obama should approve the Keystone XL pipeline.…

Pegasus XL GALEX

NASA Image and Video Library

2003-03-13

In the Multi-Payload Processing Facility, the Pegasus XL launch vehicle is in position for mating of the Galaxy Evolution Explorer (GALEX) satellite. The GALEX, set to launch April 2 from Cape Canaveral Air Force Station, will carry into space an orbiting telescope that will observe a million galaxies across 10 billion years of cosmic history to help astronomers determine when the stars and elements we see today had their origins. The spacecraft will sweep the skies for 28 months using state-of-the-art ultraviolet detectors to single out galaxies dominated by young, hot, short-lived stars that give off a great deal of energy at that wavelength. These galaxies are actively creating stars, and therefore provide a window into the history and causes of star formation in galaxies.

Pegasus XL GALEX

NASA Image and Video Library

2003-03-13

In the Multi-Payload Processing Facility, the Pegasus XL launch vehicle waits for mating of the Galaxy Evolution Explorer (GALEX) satellite. The GALEX, set to launch April 2 from Cape Canaveral Air Force Station, will carry into space an orbiting telescope that will observe a million galaxies across 10 billion years of cosmic history to help astronomers determine when the stars and elements we see today had their origins. The spacecraft will sweep the skies for 28 months using state-of-the-art ultraviolet detectors to single out galaxies dominated by young, hot, short-lived stars that give off a great deal of energy at that wavelength. These galaxies are actively creating stars, and therefore provide a window into the history and causes of star formation in galaxies.

Steady-state pharmacokinetics of fluvastatin in healthy subjects following a new extended release fluvastatin tablet, Lescol XL.

PubMed

Barilla, Denise; Prasad, Pratapa; Hubert, Martine; Gumbhir-Shah, Kavita

2004-03-01

This was an open-label, randomized, three-period, three-treatment, multiple dose, crossover study in 12 healthy male and female subjects. This study evaluated single dose and steady-state pharmacokinetics of fluvastatin following single and multiple dose administrations of a new extended release fluvastatin 8 h matrix tablet, Lescol XL 80 mg and 160 mg doses once a day. The study also included a twice a day administration of an immediate release (IR) form of fluvastatin capsule, Lescol, for comparative purposes. All doses were administered for 7 days. The safety and tolerability were also assessed. The pharmacokinetics of fluvastatin were evaluated on days 1 and 7 following each treatment. Fluvastatin systemic exposure was 50% less when administered as Lescol XL 80 mg qd compared with Lescol IR 40 mg bid. Conversely, fluvastatin systemic exposure was 22% higher when administered as Lescol XL 160 mg qd compared with Lescol IR 40 mg bid. Single doses of Lescol XL 80 mg and 160 mg were dose proportional but, deviation (30%) from dose proportionality was observed for the Lescol XL 160 mg at steady-state. There appeared to be moderate (20%-40%) accumulation of serum fluvastatin maximal concentrations and exposure after multiple doses of Lescol XL tablets. Both Lescol XL 80 mg and 160 mg showed delayed absorption and longer apparent elimination half-life compared with fluvastatin IR capsule. Single and multiple doses of fluvastatin were generally well tolerated in this healthy volunteer population. Adverse event profiles were consistent with the published safety profile of the marketed formulations. Aside from one incidence of creatine phosphokinase (CPK) elevation (following Lescol XL 160 mg qd treatment), there were no safety concerns with any of the treatments when administered acutely (7 days). Copyright 2004 John Wiley & Sons, Ltd.

Contribution of either YY1 or BclXL-induced inhibition by the NO-donor DETANONOate in the reversal of drug resistance, both in vitro and in vivo. YY1 and BclXL are overexpressed in prostate cancer.

PubMed

Huerta-Yepez, Sara; Baritaki, Stavroula; Baay-Guzman, Guillermina; Hernandez-Luna, Marco A; Hernandez-Cueto, Angeles; Vega, Mario I; Bonavida, Benjamin

2013-02-28

Nitric oxide (NO) donors have been shown to activate or inhibit constitutively-activated survival/anti-apoptotic pathways, such as NF-κB, in cancer cells. We report here that treatment of drug-resistant human prostate carcinoma cell lines with high levels (500-1000 μM) of the NO-donor DETANONOate sensitized the resistant tumor cells to apoptosis by CDDP and the combination was synergistic. We hypothesized that DETANONOate inhibits previously identified NF-κB-regulated resistant factors such as Yin Yang 1 (YY1) and Bcl-2/BclXL. Lysates from tumor cells treated with DETANONOate showed inhibition of YY1 and BclXL expressions. Transfection with either YY1 or BclXL siRNA resulted in the inhibition of both YY1 and BclXL expressions and sensitized the cells to CDDP apoptosis. Mice bearing PC-3 tumor xenografts and treated with the combination of DETANONOate and CDDP resulted in significant inhibition of tumor growth; treatment with single agent alone did not have any effect on tumor growth. Analysis of patients TMA tissues with prostatic cancer revealed higher expression of both YY1 and BclXL as a function of tumor grades and their levels were directly correlated. Thus, both YY1 and BclXL are potential prognostic biomarkers. Overall, the above findings suggest that one mechanism of DETANONOate-induced sensitization of resistant tumor cells to CDDP correlated with the inhibition of NF-κB and its targets YY1 and BclXL. The examination of the combination of NO donors and cytotoxic therapy in the treatment of resistant prostate cancer may be warranted. Published by Elsevier Inc.

30 CFR 250.1752 - How do I remove a pipeline?

Code of Federal Regulations, 2012 CFR

2012-07-01

... minimize such impacts; and (7) Projected removal schedule and duration. (b) Pig the pipeline, unless the Regional Supervisor determines that pigging is not practical; and (c) Flush the pipeline. ...

30 CFR 250.1752 - How do I remove a pipeline?

Code of Federal Regulations, 2013 CFR

2013-07-01

... minimize such impacts; and (7) Projected removal schedule and duration. (b) Pig the pipeline, unless the Regional Supervisor determines that pigging is not practical; and (c) Flush the pipeline. ...

30 CFR 250.1752 - How do I remove a pipeline?

Code of Federal Regulations, 2014 CFR

2014-07-01

... minimize such impacts; and (7) Projected removal schedule and duration. (b) Pig the pipeline, unless the Regional Supervisor determines that pigging is not practical; and (c) Flush the pipeline. ...

77 FR 48145 - Cameron Interstate Pipeline, LLC, Cameron LNG, LLC; Notice of Intent To Prepare an Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-13

... operation of the Cameron Pipeline Expansion Project and the Cameron Liquefied Natural Gas (LNG) Liquefaction... Pipeline Expansion Project would be constructed and operated to provide natural gas to the planned export...-diameter pipeline extending from an interconnection with the Florida Gas Transmission Pipeline in Calcasieu...

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-11

Inside Building 1555 at Vandenberg Air Force Base in California, technicians and engineers install one of eight NASA Cyclone Global Navigation Satellite System (CYGNSS) spacecraft on its deployment module. Processing activities will prepare the spacecraft for launch aboard an Orbital ATK Pegasus XL rocket. When preparations are competed at Vandenberg, the rocket will be transported to NASA’s Kennedy Space Center in Florida attached to the Orbital ATK L-1011 carrier aircraft with in its payload fairing. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-11

Inside Building 1555 at Vandenberg Air Force Base in California, NASA’s Cyclone Global Navigation Satellite System (CYGNSS) deployment module is inspected prior to installation of eight spacecraft that will be part of the program’s constellation of spacecraft. Processing activities will prepare the spacecraft for launch aboard an Orbital ATK Pegasus XL rocket. When preparations are competed at Vandenberg, the rocket will be transported to NASA’s Kennedy Space Center in Florida attached to the Orbital ATK L-1011 carrier aircraft with in its payload fairing. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Microsats Installation on Deployment Module

NASA Image and Video Library

2016-10-11

Inside Building 1555 at Vandenberg Air Force Base in California, one of eight NASA Cyclone Global Navigation Satellite System (CYGNSS) spacecraft is installed on its deployment module. Processing activities will prepare the spacecraft for launch aboard an Orbital ATK Pegasus XL rocket. When preparations are competed at Vandenberg, the rocket will be transported to NASA’s Kennedy Space Center in Florida attached to the Orbital ATK L-1011 carrier aircraft with in its payload fairing. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Commissioning of a new helium pipeline

NASA Technical Reports Server (NTRS)

2000-01-01

At the commissioning of a new high-pressure helium pipeline at Kennedy Space Center, Ramon Lugo, acting executive director, JPMO , presents a plaque to Center Director Roy Bridges. The pipeline will service launch needs at the new Delta IV Complex 37 at Cape Canaveral Air Force Station. Others at the ceremony were Jerry Jorgensen, pipeline project manager, Space Gateway Support (SGS); Col. Samuel Dick, representative of the 45th Space Wing; David Herst, director, Delta IV Launch Sites; Pierre Dufour, president and CEO, Air Liquide America Corporation; and Michael Butchko, president, SGS. The nine-mile-long buried pipeline will also serve as a backup helium resource for Shuttle launches. Nearly one launch's worth of helium will be available in the pipeline to support a Shuttle pad in an emergency. The line originates at the Helium Facility on KSC and terminates in a meter station at the perimeter of the Delta IV launch pad.

Commissioning of a new helium pipeline

NASA Technical Reports Server (NTRS)

2000-01-01

Jerry Jorgensen, pipeline project manager, Space Gateway Support (SGS) presents an award of appreciation to H.T. Everett, KSC Propellants manager, at the commissioning of a new high-pressure helium pipeline at Kennedy Space Center. The pipeline will service launch needs at the new Delta IV Complex 37 at Cape Canaveral Air Force Station. The nine-mile-long buried pipeline will also serve as a backup helium resource for Shuttle launches. Nearly one launch's worth of helium will be available in the pipeline to support a Shuttle pad in an emergency. The line originates at the Helium Facility on KSC and terminates in a meter station at the perimeter of the Delta IV launch pad. Others at the ceremony were Center Director Roy Bridges;); Col. Samuel Dick, representative of the 45th Space Wing; Ramon Lugo, acting executive director, JPMO; David Herst, director, Delta IV Launch Sites; Pierre Dufour, president and CEO, Air Liquide America Corporation; and Michael Butchko, president, SGS.

Commissioning of a new helium pipeline

NASA Technical Reports Server (NTRS)

2000-01-01

Jerry Jorgensen welcomes the audience to the commissioning of a new high-pressure helium pipeline at Kennedy Space Center. Jorgensen, with Space Gateway Support (SGS), is the pipeline project manager. To the right is Ramon Lugo, acting executive director, JPMO. Others at the ceremony were Center Director Roy Bridges; Col. Samuel Dick, representative of the 45th Space Wing; David Herst, director, Delta IV Launch Sites; Pierre Dufour, president and CEO, Air Liquide America Corporation; and Michael Butchko, president, SGS. The pipeline will service launch needs at the new Delta IV Complex 37 at Cape Canaveral Air Force Station. The nine-mile-long buried pipeline will also serve as a backup helium resource for Shuttle launches. Nearly one launch's worth of helium will be available in the pipeline to support a Shuttle pad in an emergency. The line originates at the Helium Facility on KSC and terminates in a meter station at the perimeter of the Delta IV launch pad.

Aerial image databases for pipeline rights-of-way management

NASA Astrophysics Data System (ADS)

Jadkowski, Mark A.

1996-03-01

Pipeline companies that own and manage extensive rights-of-way corridors are faced with ever-increasing regulatory pressures, operating issues, and the need to remain competitive in today's marketplace. Automation has long been an answer to the problem of having to do more work with less people, and Automated Mapping/Facilities Management/Geographic Information Systems (AM/FM/GIS) solutions have been implemented at several pipeline companies. Until recently, the ability to cost-effectively acquire and incorporate up-to-date aerial imagery into these computerized systems has been out of the reach of most users. NASA's Earth Observations Commercial Applications Program (EOCAP) is providing a means by which pipeline companies can bridge this gap. The EOCAP project described in this paper includes a unique partnership with NASA and James W. Sewall Company to develop an aircraft-mounted digital camera system and a ground-based computer system to geometrically correct and efficiently store and handle the digital aerial images in an AM/FM/GIS environment. This paper provides a synopsis of the project, including details on (1) the need for aerial imagery, (2) NASA's interest and role in the project, (3) the design of a Digital Aerial Rights-of-Way Monitoring System, (4) image georeferencing strategies for pipeline applications, and (5) commercialization of the EOCAP technology through a prototype project at Algonquin Gas Transmission Company which operates major gas pipelines in New England, New York, and New Jersey.

Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization.

PubMed

Shah, O Jameel; Lin, Xiaoyu; Li, Leiming; Huang, Xiaoli; Li, Junling; Anderson, Mark G; Tang, Hua; Rodriguez, Luis E; Warder, Scott E; McLoughlin, Shaun; Chen, Jun; Palma, Joann; Glaser, Keith B; Donawho, Cherrie K; Fesik, Stephen W; Shen, Yu

2010-07-13

Aurora kinase B inhibitors induce apoptosis secondary to polyploidization and have entered clinical trials as an emerging class of neocytotoxic chemotherapeutics. We demonstrate here that polyploidization neutralizes Mcl-1 function, rendering cancer cells exquisitely dependent on Bcl-XL/-2. This "addiction" can be exploited therapeutically by combining aurora kinase inhibitors and the orally bioavailable BH3 mimetic, ABT-263, which inhibits Bcl-XL, Bcl-2, and Bcl-w. The combination of ABT-263 with aurora B inhibitors produces a synergistic loss of viability in a range of cell lines of divergent tumor origin and exhibits more sustained tumor growth inhibition in vivo compared with aurora B inhibitor monotherapy. These data demonstrate that Bcl-XL/-2 is necessary to support viability during polyploidization in a variety of tumor models and represents a druggable molecular vulnerability with potential therapeutic utility.

Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization

PubMed Central

Shah, O. Jameel; Lin, Xiaoyu; Li, Leiming; Huang, Xiaoli; Li, Junling; Anderson, Mark G.; Tang, Hua; Rodriguez, Luis E.; Warder, Scott E.; McLoughlin, Shaun; Chen, Jun; Palma, Joann; Glaser, Keith B.; Donawho, Cherrie K.; Fesik, Stephen W.; Shen, Yu

2010-01-01

Aurora kinase B inhibitors induce apoptosis secondary to polyploidization and have entered clinical trials as an emerging class of neocytotoxic chemotherapeutics. We demonstrate here that polyploidization neutralizes Mcl-1 function, rendering cancer cells exquisitely dependent on Bcl-XL/-2. This “addiction” can be exploited therapeutically by combining aurora kinase inhibitors and the orally bioavailable BH3 mimetic, ABT-263, which inhibits Bcl-XL, Bcl-2, and Bcl-w. The combination of ABT-263 with aurora B inhibitors produces a synergistic loss of viability in a range of cell lines of divergent tumor origin and exhibits more sustained tumor growth inhibition in vivo compared with aurora B inhibitor monotherapy. These data demonstrate that Bcl-XL/-2 is necessary to support viability during polyploidization in a variety of tumor models and represents a druggable molecular vulnerability with potential therapeutic utility. PMID:20616035

Garden Banks 388 deepwater pipeline span avoidance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, S.W.; Sawyer, M.A.; Kenney, T.D.

1995-12-31

This paper will describe the span avoidance measures taken for the installation of the Garden Banks 388 deepwater oil and gas gathering pipelines. The two 12 inch pipelines connect a shallow water facility in EI-315 to a deep water subsea template in GB-388. These pipelines run across the irregular continental slope typically found in moderate to deep water in the Gulf of Mexico. To minimize pipeline spans, steps were taken during design, survey, and installation phases of the project. During each phase, as additional information became available, analyses and resulting recommended approaches were refined. This continuity, seldom easily obtained, provedmore » beneficial in translating design work into field results.« less

The Oman-India gas pipeline

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberts, P.M.

1995-12-31

In March 1993, the Governments of the Sultanate of Oman and India executed a Memorandum of Understanding for a long term Gas Supply Contract to transport natural gas from Oman to India by pipeline. A feasibility study was undertaken to determine if such a pipeline was technically achievable and economically attractive. Work was initiated with a consortium of internationally recognized major design and construction firms, as well as with consultants knowledgeable in gas supply and demand in the region. Alternative gas supply volumes as well as two distinct pipeline routes were analyzed in significant detail. As a result of thismore » work, it was concluded that a pipeline crossing, taking a direct route from Oman to India, is economically and technically feasible. In September, 1994, the Agreement on Principal Terms for supply of gas to India from Oman was agreed by the respective governmental authorities. The project and its status are described.« less

Pegasus XL CYGNSS Blacklight Test and Thermal Ring Installation

NASA Image and Video Library

2016-10-25

NASA's Cyclone Global Navigation Satellite System (CYGNSS) spacecraft undergoes a black light test in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA's Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

30 CFR 250.1752 - How do I remove a pipeline?

Code of Federal Regulations, 2011 CFR

2011-07-01

... minimize such impacts; and (7) Projected removal schedule and duration. (b) Pig the pipeline, unless the Regional Supervisor determines that pigging is not practical; and (c) Flush the pipeline. [67 FR 35406, May...

30 CFR 250.1752 - How do I remove a pipeline?

Code of Federal Regulations, 2010 CFR

2010-07-01

... (7) Projected removal schedule and duration. (b) Pig the pipeline, unless the Regional Supervisor determines that pigging is not practical; and (c) Flush the pipeline. [67 FR 35406, May 17, 2002, as amended...

Tonopen XL assessment of intraocular pressure through silicone hydrogel contact lenses.

PubMed

Schornack, Muriel; Rice, Melissa; Hodge, David

2012-09-01

To assess the accuracy of Tonopen XL measurement of intraocular pressure (IOP) through low-power (-0.25 to -3.00) and high power (-3.25 to -6.00) silicone hydrogel lenses of 3 different materials (galyfilcon A, senofilcon A, and lotrafilcon B). Seventy-eight patients were recruited for participation in this study. All were habitual wearers of silicone hydrogel contact lenses, and none had been diagnosed with glaucoma, ocular hypertension, or anterior surface disease. IOP was measured with and without lenses in place in the right eye only. Patients were randomized to initial measurement either with or without the lens in place. A single examiner collected all data. No statistically significant differences were noted between IOP measured without lenses and IOP measured through low-power lotrafilcon B lenses or high-power or low-power galyfilcon A and senofilcon A lenses. However, we did find a statistically significant difference between IOP measured without lenses and IOP measured through high-power lotrafilcon B lenses. In general, Tonopen XL measurement of IOP through silicone hydrogel lenses may be sufficiently accurate for clinical purposes. However, Tonopen XL may overestimate IOP if performed through a silicone hydrogel lens of relatively high modulus.

Colloquium Spectroscopicum Internationale XL, Pisa (Italy), 11-16 June 2017

NASA Astrophysics Data System (ADS)

D'Ulivo, Alessandro; Legnaioli, Stefano

2017-12-01

The 40th edition of the Colloquium Spectroscopicum Internationale (CSI XL) was held in Pisa (Italy) between 11 and 16 June 2017, at the Congress Center of Pisa. It is the third time that this prestigious conference on Analytical Spectroscopy is organized in Italy after the CSI II (Venice, 1951) and CSI XVII (Florence, 1973). In this occasion, the CSI XL took place together with the 9th Euro-Mediterranean Symposium on Laser Induced Breakdown spectroscopy (IX EMSLIBS, Chaired by Vincenzo Palleschi) with the aim to have a positive impact on both conferences by fostering synergisms among participants of all ages, as well as the level of participation, in the stimulating atmosphere of a beautiful city of art in Tuscany.

F-16XL ship #1 - CAWAP outboard rake #7

NASA Technical Reports Server (NTRS)

1996-01-01

This photo shows the #7 outboard rake on the left wing of NASA's single-seat F-16XL (ship #1) used for the Cranked-Arrow Wing Aerodynamic Project (CAWAP) at Dryden Flight Research Center, Edwards, California. The modified airplane features a delta 'cranked-arrow' wing with strips of tubing along the leading edge to the trailing edge to sense static on the wing and obtain pressure distribution data. The right wing receives data on pressure distribution and the left wing has three types of instrumentation - preston tubes to measure local skin friction, boundary layer rakes to measure boundary layer profiles (the layer where the air interacts with the surfaces of a moving aircraft), and hot films to determine boundary layer transition locations. The program also gathered aero data on two wing planforms for NASA's High Speed Research Program. The first flight of CAWAP occurred on November 21, 1995, and the test program ended in April 1996.

76 FR 55157 - Final Public Meeting in Washington, DC for the Proposed Keystone XL Project

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-06

... along the pipeline route, a final meeting will be held in Washington, DC. Friday, October 7, 2011 Ronald Reagan Building and International Trade Center, Atrium Hall, 1300 Pennsylvania Avenue, Washington...

Leakage Risk Assessment of CO{sub 2} Transportation by Pipeline at the Illinois Basin Decatur Project, Decatur, Illinois

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mazzoldi, A.; Oldenburg, C. M.

The Illinois Basin Decatur Project (IBDP) is designed to confirm the ability of the Mt. Simon Sandstone, a major regional saline-water-bearing formation in the Illinois Basin, to store 1 million tons of carbon dioxide (CO{sub 2}) injected over a period of three years. The CO{sub 2} will be provided by Archer Daniels Midland (ADM) from its Decatur, Illinois, ethanol plant. In order to transport CO{sub 2} from the capture facility to the injection well (also located within the ADM plant boundaries), a high-pressure pipeline of length 3,200 ft (975 m) has been constructed, running above the ground surface within themore » ADM plant footprint. We have qualitatively evaluated risks associated with possible pipeline failure scenarios that lead to discharge of CO{sub 2} within the real-world environment of the ADM plant in which there are often workers and visitors in the vicinity of the pipeline. There are several aspects of CO{sub 2} that make its transportation and potential leakage somewhat different from other substances, most notable is its non-flammability and propensity to change to solid (dry ice) upon strong decompression. In this study, we present numerical simulations using Computational Fluid Dynamics (CFD) methods of the release and dispersion of CO{sub 2} from individual hypothetical pipeline failures (i.e., leaks). Failure frequency of the various components of a pipeline transportation system over time are taken from prior work on general pipeline safety and leakage modeling and suggest a 4.65% chance of some kind of pipeline failure over the three-years of operation. Following the Precautionary Principle (see below), we accounted for full-bore leakage scenarios, where the temporal evolution of the mass release rate from the high-pressure pipeline leak locations was simulated using a state-of-the-art Pipe model which considers the thermodynamic effects of decompression in the entire pipeline. Failures have been simulated at four representative locations

F-16XL ship #1 (#849) during first flight of the Digital Flight Control System (DFCS)

NASA Technical Reports Server (NTRS)

1997-01-01

After completing its first flight with the Digital Flight Control System on December 16, 1997, the F-16XL #1 aircraft began a series of envelope expansion flights. On January 27 and 29, 1998, it successfully completed structural clearance tests, as well as most of the load testing Only flights at Mach 1.05 at 10,000 feet, Mach 1.1 at 15,000 feet, and Mach 1.2 at 20,000 feet remained. During the next flight, on February 4, an instrumentation problem cut short the planned envelope expansion tests. After the problem was corrected, the F-16XL returned to flight status, and on February 18 and 20, flight control and evaluation flights were made. Two more research flights were planned for the following week, but another problem appeared. During the ground start up, project personnel noticed that the leading edge flap moved without being commanded. The Digital Flight Control Computer was sent to the Lockheed-Martin facility at Fort Worth, where the problem was traced to a defective chip in the computer. After it was replaced, the F-16XL #1 flew a highly successful flight controls and handling qualities evaluation flight on March 26, clearing the way for the final tests. The final limited loads expansion flight occurred on March 31, and was fully successful. As a result, the on-site Lockheed-Martin loads engineer cleared the aircraft to Mach 1.8. The remaining two handling qualities and flight control evaluation flights were both made on April 3, 1998. These three flights concluded the flight test portion of the DFCS upgrade.

Pegasus XL CYGNSS Payload Adapter Installation to Deployment Mod

NASA Image and Video Library

2016-10-17

Technicians with Orbital ATK install the payload adapter to the deployment module that contains the micro satellites for NASA’s Cyclone Global Navigation Satellite System (CYGNSS) in Building 1555 at Vandenberg Air Force Base in California. CYGNSS is being prepared at Vandenberg, and then will be transported to NASA’s Kennedy Space Center in Florida aboard the Orbital ATK Pegasus XL rocket which will be attached to the Orbital ATK L-1011 carrier aircraft. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

High-temperature MIRAGE XL (LFRA) IRSP system development

NASA Astrophysics Data System (ADS)

McHugh, Steve; Franks, Greg; LaVeigne, Joe

2017-05-01

The development of very-large format infrared detector arrays has challenged the IR scene projector community to develop larger-format infrared emitter arrays. Many scene projector applications also require much higher simulated temperatures than can be generated with current technology. This paper will present an overview of resistive emitterbased (broadband) IR scene projector system development, as well as describe recent progress in emitter materials and pixel designs applicable for legacy MIRAGE XL Systems to achieve apparent temperatures >1000K in the MWIR. These new high temperature MIRAGE XL (LFRA) Digital Emitter Engines (DEE) will be "plug and play" equivalent with legacy MIRAGE XL DEEs, the rest of the system is reusable. Under the High Temperature Dynamic Resistive Array (HDRA) development program, Santa Barbara Infrared Inc. (SBIR) is developing a new infrared scene projector architecture capable of producing both very large format (>2k x 2k) resistive emitter arrays and improved emitter pixel technology capable of simulating very high apparent temperatures. During earlier phases of the program, SBIR demonstrated materials with MWIR apparent temperatures in excess of 1500 K. These new emitter materials can be utilized with legacy RIICs to produce pixels that can achieve 7X the radiance of the legacy systems with low cost and low risk. A 'scalable' Read-In Integrated Circuit (RIIC) is also being developed under the same HDRA program to drive the high temperature pixels. This RIIC will utilize through-silicon via (TSV) and Quilt Packaging (QP) technologies to allow seamless tiling of multiple chips to fabricate very large arrays, and thus overcome the yield limitations inherent in large-scale integrated circuits. These quilted arrays can be fabricated in any N x M size in 512 steps.

Interchangeability of Procalcitonin Measurements Using the Point of Care Testing i-CHROMATM Reader and the Automated Liaison XL.

PubMed

Stenner, Elisabetta; Barbati, Giulia; West, Nicole; Ben, Fabia Del; Martin, Francesca; Ruscio, Maurizio

2018-06-01

Our aim was to verify if procalcitonin (PCT) measurements using the new point-of-care testing i-CHROMATM are interchangeable with those of Liaison XL. One hundred seventeen serum samples were processed sequentially on a Liaison XL and i-CHROMATM. Statistical analysis was done using the Passing-Bablok regression, Bland-Altman test, and Cohen's Kappa statistic. Proportional and constant differences were observed between i-CHROMATM and Liaison XL. The 95% CI of the mean bias% was very large, exceeding the maximum allowable TE% and the clinical reference change value. However, the concordance between methods at the clinical relevant cutoffs was strong, with the exception of the 0.25 ng/mL cutoff which was moderate. Our data suggest that i-CHROMATM is not interchangeable with Liaison XL. However, while the strong concordance at the clinical relevant cutoffs allows us to consider i-CHROMATM a suitable option to Liaison XL to support clinicians' decision-making; nevertheless, the moderate agreement at the 0.25 ng/mL cutoff recommends caution in interpreting the data around this cutoff.

Commissioning of a new helium pipeline

NASA Technical Reports Server (NTRS)

2000-01-01

Center Director Roy Bridges addresses the audience at the commissioning of a new high-pressure helium pipeline at Kennedy Space Center that will service launch needs at the new Delta IV Complex 37 at Cape Canaveral Air Force Station. The nine-mile- long buried pipeline will also serve as a backup helium resource for Shuttle launches. Nearly one launch's worth of helium will be available in the pipeline to support a Shuttle pad in an emergency. The line originates at the Helium Facility on KSC and terminates in a meter station at the perimeter of the Delta IV launch pad. Others at the ceremony were Jerry Jorgensen, pipeline project manager, Space Gateway Support (SGS); Col. Samuel Dick, representative of the 45th Space Wing; Ramon Lugo, acting executive director, JPMO; David Herst, director, Delta IV Launch Sites; Pierre Dufour, president and CEO, Air Liquide America Corporation; and Michael Butchko, president, SGS.

Toward Improved CFD Predictions of Slender Airframe Aerodynamics Using the F-16XL Aircraft (CAWAPI-2)

NASA Technical Reports Server (NTRS)

Luckring, James M.; Rizzi, Arthur; Davis, M. Bruce

2014-01-01

A coordinated project has been underway to improve CFD predictions of slender airframe aerodynamics. The work is focused on two flow conditions and leverages a unique flight data set obtained with an F-16XL aircraft. These conditions, a low-speed high angleof- attack case and a transonic low angle-of-attack case, were selected from a prior prediction campaign wherein the CFD failed to provide acceptable results. In this paper the background, objectives and approach to the current project are presented. The work embodies predictions from multiple numerical formulations that are contributed from multiple organizations, and the context of this campaign to other multi-code, multiorganizational efforts is included. The relevance of this body of work toward future supersonic commercial transport concepts is also briefly addressed.

An Aperture Photometry Pipeline for K2 Data

NASA Astrophysics Data System (ADS)

Buzasi, Derek L.; Carboneau, Lindsey; Lezcano, Andy; Vydra, Ekaterina

2016-01-01

As part of an ongoing research program with undergraduate students at Florida Gulf Coast University, we have constructed an aperture photometry pipeline for K2 data. The pipeline performs dynamic automated aperture mask definition for all targets in the K2 fields, followed by aperture photometry and detrending. Our pipeline is currently used to support a number of projects, including studies of stellar rotation and activity, red giant asteroseismology, gyrochronology, and exoplanet searches. In addition, output is used to support an undergraduate class on exoplanets aimed at a student audience of both majors and non-majors. The pipeline is designed for both batch and single-target use, and is easily extensible to data from other missions, and pipeline output is available to the community. This paper will describe our pipeline and its capabilities and illustrate the quality of the results, drawing on all of the applications for which it is currently used.

ECDA of Cased Pipeline Segments

DOT National Transportation Integrated Search

2010-06-01

On June 28, 2007, PHMSA released a Broad Agency Announcement (BAA), DTPH56-07-BAA-000002, seeking white papers on individual projects and consolidated Research and Development (R&D) programs addressing topics on pipeline safety program. Although, not...

Pegasus XL CYGNSS Solar Panel Deployment and Illumination Test

NASA Image and Video Library

2016-10-02

Inside Building 1555 at Vandenberg Air Force Base in California, solar panels for one of eight NASA's Cyclone Global Navigation Satellite System (CYGNSS) spacecraft has been deployed for illumination testing. Processing activities will prepare the spacecraft for launch aboard an Orbital ATK Pegasus XL rocket. When preparations are completed at Vandenberg, the rocket will be transported to NASA's Kennedy Space Center in Florida attached to the Orbital ATK L-1011 carrier aircraft within its payload fairing. CYGNSS will launch on the Pegasus XL rocket from the Skid Strip at Cape Canaveral Air Force Station. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

Characterization of X-linked Hypohidrotic Ectodermal Dysplasia (XL-HED) Hair and Sweat Gland Phenotypes Using Phototrichogram Analysis and Live Confocal Imaging

PubMed Central

Jones, Kyle B.; Goodwin, Alice F.; Landan, Maya; Seidel, Kerstin; Tran, Dong-Kha; Hogue, Jacob; Chavez, Miquella; Fete, Mary; Yu, Wenli; Hussein, Tarek; Johnson, Ramsey; Huttner, Kenneth; Jheon, Andrew H.; Klein, Ophir D.

2015-01-01

Hypohidrotic ectodermal dysplasia (HED) is the most common type of ectodermal dysplasia (ED), which encompasses a large group of syndromes that share several phenotypic features such as missing or malformed ectodermal structures, including skin, hair, sweat glands, and teeth. X-linked hypohidrotic ectodermal dysplasia (XL-HED) is associated with mutations in ectodysplasin (EDA1). Hypohidrosis due to hypoplastic sweat glands and thin, sparse hair are phenotypic features that significantly affect the daily lives of XL-HED individuals and therefore require systematic analysis. We sought to determine the quality of life of individuals with XL-HED and to quantify sweat duct and hair phenotypes using confocal imaging, pilocarpine iontophoresis, and phototrichogram analysis. Using these highly sensitive and non-invasive techniques, we demonstrated that 11/12 XL-HED individuals presented with a complete absence of sweat ducts and that none produced sweat. We determined that the thin hair phenotype observed in XL-HED was due to multiple factors, such as fewer terminal hairs with decreased thickness and slower growth rate, as well as fewer follicular units and fewer hairs per unit. The precise characterization of XL-HED phenotypes using sensitive and non-invasive techniques presented in our study will improve upon larger genotype-phenotype studies and in the assessment of future therapies in XL-HED. PMID:23687000

76 FR 5580 - Eagle Crest Energy Company; Notice of Applicant-Proposed Water Pipeline Route for the Proposed...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-01

... Hydroelectric Project (Eagle Mountain Project). This notice describes the water supply pipeline route proposed... property that would be crossed by the proposed water supply pipeline. We are currently soliciting comments on the proposed water supply pipeline and the draft EIS. Additionally, as discussed below, we will be...

ML-o-Scope: A Diagnostic Visualization System for Deep Machine Learning Pipelines

DTIC Science & Technology

2014-05-16

ML-o-scope: a diagnostic visualization system for deep machine learning pipelines Daniel Bruckner Electrical Engineering and Computer Sciences... machine learning pipelines 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f...the system as a support for tuning large scale object-classification pipelines. 1 Introduction A new generation of pipelined machine learning models

CDF-XL: computing cumulative distribution functions of reaction time data in Excel.

PubMed

Houghton, George; Grange, James A

2011-12-01

In experimental psychology, central tendencies of reaction time (RT) distributions are used to compare different experimental conditions. This emphasis on the central tendency ignores additional information that may be derived from the RT distribution itself. One method for analysing RT distributions is to construct cumulative distribution frequency plots (CDFs; Ratcliff, Psychological Bulletin 86:446-461, 1979). However, this method is difficult to implement in widely available software, severely restricting its use. In this report, we present an Excel-based program, CDF-XL, for constructing and analysing CDFs, with the aim of making such techniques more readily accessible to researchers, including students (CDF-XL can be downloaded free of charge from the Psychonomic Society's online archive). CDF-XL functions as an Excel workbook and starts from the raw experimental data, organised into three columns (Subject, Condition, and RT) on an Input Data worksheet (a point-and-click utility is provided for achieving this format from a broader data set). No further preprocessing or sorting of the data is required. With one click of a button, CDF-XL will generate two forms of cumulative analysis: (1) "standard" CDFs, based on percentiles of participant RT distributions (by condition), and (2) a related analysis employing the participant means of rank-ordered RT bins. Both analyses involve partitioning the data in similar ways, but the first uses a "median"-type measure at the participant level, while the latter uses the mean. The results are presented in three formats: (i) by participants, suitable for entry into further statistical analysis; (ii) grand means by condition; and (iii) completed CDF plots in Excel charts.

Pegasus XL CYGNSS Second Launch Attempt

NASA Image and Video Library

2016-12-15

An Orbital ATK L-1011 Stargazer touches down at the Skid Strip at Cape Canaveral Air Force Station in Florida. The aircraft carried a Pegasus XL Rocket with eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, for launch. With the aircraft flying off shore, the Pegasus rocket was released at 8:37 a.m. EST. Five seconds later, the solid propellant engine ignited and boosted the eight hurricane observatories to orbit. The eight CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes.

Pegasus XL CYGNSS Second Launch Attempt

NASA Image and Video Library

2016-12-15

An Orbital ATK L-1011 Stargazer aircraft carrying a Pegasus XL Rocket with eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft is being readied for takeoff from the Skid Strip at Cape Canaveral Air Force Station, Florida. With the aircraft flying off shore, the Pegasus rocket will be released. Five seconds later, the solid propellant engine will ignite and boost the eight hurricane observatories to orbit. The eight CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes.

Pegasus XL CYGNSS Second Launch Attempt

NASA Image and Video Library

2016-12-15

An Orbital ATK L-1011 Stargazer aircraft carrying a Pegasus XL Rocket with eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft takes off from the Skid Strip at Cape Canaveral Air Force Station, Florida. With the aircraft flying off shore, the Pegasus rocket will be released. Five seconds later, the solid propellant engine will ignite and boost the eight hurricane observatories to orbit. The eight CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes.

Pegasus XL CYGNSS Second Launch Attempt

NASA Image and Video Library

2016-12-15

An Orbital ATK L-1011 Stargazer aircraft carrying a Pegasus XL Rocket with eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft is ready for takeoff from the Skid Strip at Cape Canaveral Air Force Station, Florida. With the aircraft flying off shore, the Pegasus rocket will be released. Five seconds later, the solid propellant engine will ignite and boost the eight hurricane observatories to orbit. The eight CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes.

[Comparison of the M and XL FibroScan(®) probes to estimate liver stiffness by transient elastography].

PubMed

Herrero, José Ignacio; Iñarrairaegui, Mercedes; D'Avola, Delia; Sangro, Bruno; Prieto, Jesús; Quiroga, Jorge

2014-04-01

The FibroScan(®) XL probe has been specifically designed for obese patients to measure liver stiffness by transient elastography, but it has not been well tested in non-obese patients. The aim of this study was to compare the M and XL FibroScan(®) probes in a series of unselected obese (body mass index above 30 kg/m(2)) and non-obese patients with chronic liver disease. Two hundred and fifty-four patients underwent a transient elastography examination with both the M and XL probes. The results obtained with the two probes were compared in the whole series and in obese (n=82) and non-obese (n=167) patients separately. The reliability of the examinations was assessed using the criteria defined by Castéra et al. The proportion of reliable exams was significantly higher when the XL probe was used (83% versus 73%; P=.001). This significance was maintained in the group of obese patients (82% versus 55%; P<.001), but not in the non-obese patients (84% versus 83%). Despite a high correlation between the stiffness values obtained with the two probes (R=.897; P<.001), and a high concordance in the estimation of fibrosis obtained with the two probes (Cronbach's alpha value: 0.932), the liver stiffness values obtained with the XL probe were significantly lower than those obtained with the M probe, both in the whole series (9.5 ± 9.1 kPa versus 11.3 ± 12.6 kPa; P<0.001) and in the obese and non-obese groups. In conclusion, transient elastography with the XL probe allows a higher proportion of reliable examinations in obese patients but not in non-obese patients. Stiffness values were lower with the XL probe than with the M probe. Copyright © 2013 Elsevier España, S.L. and AEEH y AEG. All rights reserved.

Pegasus XL CYGNSS Prepared for Launch Aboard Orbital ATK's L-101

NASA Image and Video Library

2016-12-10

At Cape Canaveral Air Force Station's Skid Strip the Orbital ATK L-1011 Stargazer aircraft is being prepared to launch NASA's Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. The eight micro satellites are aboard an Orbital ATK Pegasus XL rocket strapped to the underside of the Stargazer. CYGNSS is scheduled for its airborne launch aboard the Pegasus XL rocket from the Skid Strip on Dec. 12. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

77 FR 70543 - Pipeline Safety: Meeting of the Gas Pipeline Advisory Committee and the Liquid Pipeline Advisory...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-26

.... PHMSA-2009-0203] Pipeline Safety: Meeting of the Gas Pipeline Advisory Committee and the Liquid Pipeline..., and safety policies for natural gas pipelines and for hazardous liquid pipelines. Both committees were...: Notice of advisory committee meeting. SUMMARY: This notice announces a public meeting of the Gas Pipeline...

Myeloid leukemia factor 1 interfered with Bcl-XL to promote apoptosis and its function was regulated by 14-3-3.

PubMed

Sun, Yi; Fu, Amina; Xu, Wu; Chao, Jyh-Rong; Moshiach, Simon; Morris, Stephan W

2015-12-01

Myeloid leukemia factor 1 (MLF1) was involved in t(3;5) chromosomal rearrangement and aberrantly expressed in myelodysplastic syndromes/acute myeloid leukemia patients. Ex vivo experiments showed that the lymphocytes from the Mlf1-deficient mice were more resistant to apoptotic stimulations than the wild-type cells. Furthermore, the ectopically expressed MLF1 induced apoptosis in the cell models. These findings revealed that MLF1 was required for the cells to respond to the apoptotic stimulations. Ex vivo experiments also demonstrated that cytokine withdrawal significantly up-regulated Mlf1's expression and promoted its association with B cell lymphoma-extra large (Bcl-XL) in the lymphocytes, at the same time reduced the association of Bax with Bcl-XL The same effects were also observed in the cells that over-expressed MLF1. However, these effects were observed in Mlf1 null lymphocytes as well as the cells over-expressing Bcl-XL. In addition, MLF1's proapoptosis could be completely prevented by co-expression of Bcl-XL and significantly attenuated in Bax/Bak double null cells. These data, taken together, strongly suggested that in response to the stresses, up-regulated Mlf1 promoted its association with Bcl-XL and reduced the available Bcl-XL for associating with Bax, which resulted in releasing Bax from the Bcl-XL and apoptosis in turn. Lastly, we showed that MLF1 was negatively regulated by 14-3-3 and revealed that 14-3-3 bound to MLF1 and physically blocked MLF1's Bcl-2 homology domain 3 (BH3) as well as Bcl-XL from associating with MLF1. Our findings suggested that ectopically expressed MLF1 could be responsible for the pathological apoptosis in early myelodysplastic syndrome (MDS) patients.

Energy intensity, life-cycle greenhouse gas emissions, and economic assessment of liquid biofuel pipelines.

PubMed

Strogen, Bret; Horvath, Arpad; Zilberman, David

2013-12-01

Petroleum fuels are predominantly transported domestically by pipelines, whereas biofuels are almost exclusively transported by rail, barge, and truck. As biofuel production increases, new pipelines may become economically attractive. Location-specific variables impacting pipeline viability include construction costs, availability and costs of alternative transportation modes, electricity prices and emissions (if priced), throughput, and subsurface temperature. When transporting alcohol or diesel-like fuels, pipelines have a lower direct energy intensity than rail, barge, and trucks if fluid velocity is under 1 m/s for 4-inch diameter pipelines and 2 m/s for 8-inch or larger pipelines. Across multiple hypothetical state-specific scenarios, profit-maximizing design velocities range from 1.2 to 1.9 m/s. In costs and GHG emissions, optimized pipelines outperform trucks in each state and rail and barge in most states, if projected throughput exceeds four billion liters/year. If emissions are priced, optimum design diameters typically increase to reduce pumping energy demands, increasing the cost-effectiveness of pipeline projects. Copyright © 2013 Elsevier Ltd. All rights reserved.

Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models.

PubMed

Punnoose, Elizabeth A; Leverson, Joel D; Peale, Franklin; Boghaert, Erwin R; Belmont, Lisa D; Tan, Nguyen; Young, Amy; Mitten, Michael; Ingalla, Ellen; Darbonne, Walter C; Oleksijew, Anatol; Tapang, Paul; Yue, Peng; Oeh, Jason; Lee, Leslie; Maiga, Sophie; Fairbrother, Wayne J; Amiot, Martine; Souers, Andrew J; Sampath, Deepak

2016-05-01

BCL-2 family proteins dictate survival of human multiple myeloma cells, making them attractive drug targets. Indeed, multiple myeloma cells are sensitive to antagonists that selectively target prosurvival proteins such as BCL-2/BCL-XL (ABT-737 and ABT-263/navitoclax) or BCL-2 only (ABT-199/GDC-0199/venetoclax). Resistance to these three drugs is mediated by expression of MCL-1. However, given the selectivity profile of venetoclax it is unclear whether coexpression of BCL-XL also affects antitumor responses to venetoclax in multiple myeloma. In multiple myeloma cell lines (n = 21), BCL-2 is expressed but sensitivity to venetoclax correlated with high BCL-2 and low BCL-XL or MCL-1 expression. Multiple myeloma cells that coexpress BCL-2 and BCL-XL were resistant to venetoclax but sensitive to a BCL-XL-selective inhibitor (A-1155463). Multiple myeloma xenograft models that coexpressed BCL-XL or MCL-1 with BCL-2 were also resistant to venetoclax. Resistance to venetoclax was mitigated by cotreatment with bortezomib in xenografts that coexpressed BCL-2 and MCL-1 due to upregulation of NOXA, a proapoptotic factor that neutralizes MCL-1. In contrast, xenografts that expressed BCL-XL, MCL-1, and BCL-2 were more sensitive to the combination of bortezomib with a BCL-XL selective inhibitor (A-1331852) but not with venetoclax cotreatment when compared with monotherapies. IHC of multiple myeloma patient bone marrow biopsies and aspirates (n = 95) revealed high levels of BCL-2 and BCL-XL in 62% and 43% of evaluable samples, respectively, while 34% were characterized as BCL-2(High)/BCL-XL (Low) In addition to MCL-1, our data suggest that BCL-XL may also be a potential resistance factor to venetoclax monotherapy and in combination with bortezomib. Mol Cancer Ther; 15(5); 1132-44. ©2016 AACR. ©2016 American Association for Cancer Research.

Anti-apoptotic Bcl-XL but not Mcl-1 contributes to protection against virus-induced apoptosis.

PubMed

Ohmer, Michaela; Weber, Arnim; Sutter, Gerd; Ehrhardt, Katrin; Zimmermann, Albert; Häcker, Georg

2016-08-18

Infection of mammalian cells with viruses often induces apoptosis. How the recognition of viruses leads to apoptosis of the infected cell and which host cell factors regulate this cell death is incompletely understood. In this study, we focussed on two major anti-apoptotic proteins of the host cell, whose abundance and activity are important for cell survival, the Bcl-2-like proteins Mcl-1 and Bcl-XL. During infection of epithelial cells and fibroblasts with modified vaccinia virus Ankara (MVA), Mcl-1 protein levels dropped but the MVA Bcl-2-like protein F1L could replace Mcl-1 functionally; a similar activity was found in vaccinia virus (VACV)-infected cells. During infection with murine cytomegalovirus (MCMV), Mcl-1-levels were not reduced but a viral Mcl-1-like activity was also generated. Infection of mouse macrophages with any of these viruses, on the other hand, induced apoptosis. Virus-induced macrophage apoptosis was unaltered in the absence of Mcl-1. However, apoptosis was substantially increased in infected Bcl-XL-deficient macrophages or macrophages treated with the Bcl-2/Bcl-XL-inhibitor ABT-737. Genetic loss of Bcl-XL or treatment of macrophages with ABT-737 reduced the generation of infectious VACV. These data show that Mcl-1 is dispensable for the regulation of apoptosis during infection with different large DNA viruses, either because the viruses replace its function (in fibroblasts and epithelial cells) or because the pro-apoptotic activity generated by the infection appears not to be blocked by it (in macrophages). Bcl-XL, on the other hand, can be important to maintain survival of virus-infected cells, and its activity can determine outcome of the infection.

Anti-apoptotic Bcl-XL but not Mcl-1 contributes to protection against virus-induced apoptosis

PubMed Central

Ohmer, Michaela; Weber, Arnim; Sutter, Gerd; Ehrhardt, Katrin; Zimmermann, Albert; Häcker, Georg

2016-01-01

Infection of mammalian cells with viruses often induces apoptosis. How the recognition of viruses leads to apoptosis of the infected cell and which host cell factors regulate this cell death is incompletely understood. In this study, we focussed on two major anti-apoptotic proteins of the host cell, whose abundance and activity are important for cell survival, the Bcl-2-like proteins Mcl-1 and Bcl-XL. During infection of epithelial cells and fibroblasts with modified vaccinia virus Ankara (MVA), Mcl-1 protein levels dropped but the MVA Bcl-2-like protein F1L could replace Mcl-1 functionally; a similar activity was found in vaccinia virus (VACV)-infected cells. During infection with murine cytomegalovirus (MCMV), Mcl-1-levels were not reduced but a viral Mcl-1-like activity was also generated. Infection of mouse macrophages with any of these viruses, on the other hand, induced apoptosis. Virus-induced macrophage apoptosis was unaltered in the absence of Mcl-1. However, apoptosis was substantially increased in infected Bcl-XL-deficient macrophages or macrophages treated with the Bcl-2/Bcl-XL-inhibitor ABT-737. Genetic loss of Bcl-XL or treatment of macrophages with ABT-737 reduced the generation of infectious VACV. These data show that Mcl-1 is dispensable for the regulation of apoptosis during infection with different large DNA viruses, either because the viruses replace its function (in fibroblasts and epithelial cells) or because the pro-apoptotic activity generated by the infection appears not to be blocked by it (in macrophages). Bcl-XL, on the other hand, can be important to maintain survival of virus-infected cells, and its activity can determine outcome of the infection. PMID:27537523

An assessment of people's satisfaction with the public hearing on the Yadana Natural Gas Pipeline project.

PubMed

Ogunlana, S; Yotsinsak, T; Yisa, S

2001-11-01

Many public and large-scale construction projects in Thailand have been faced with environmental and social conflict problems. The major cause is that project sponsors do not address concerns of the public in a proper manner during EIA study. The Yadana Natural Gas Pipeline (YNGP) project is an example of a project which suffered the effects of public demonstration. A public hearing, one technique of public participation, is a good mechanism to solve conflict problems in a non-violent way which the Thai Government usually adopts to settle conflict in construction projects. In the case of the YNGP, even after the conflict was 'resolved' hostility towards the project was not eliminated, as the opponents were not satisfied with the decision. Therefore, this article examines the hearing on the YNGP project. The study found that it was too late to make any significant changes to the project after the hearing was held, most respondents were not satisfied with the project. In other words, this hearing did not improve their perception of environmental soundness of the project. The study showed that the project's impact on the environment was not properly addressed. The project sponsors did not provide sufficient publicity for the meeting and the stage at which the hearing was conducted. Suggestions are made for improving participation in future hearings.

78 FR 70623 - Pipeline Safety: Meeting of the Gas Pipeline Advisory Committee and the Liquid Pipeline Advisory...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-26

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2009-0203] Pipeline Safety: Meeting of the Gas Pipeline Advisory Committee and the Liquid Pipeline Advisory Committee AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. [[Page...

Modeling of microbial induced corrosion on metallic pipelines resulting from biomethane and the integrity impact of biomethane on non-metallic pipelines.

DOT National Transportation Integrated Search

2012-09-01

The objective of this project is to understand key elements related to promoting the successful delivery of : biomethane into natural gas pipeline networks. This project focuses on two key areas of concern: : 1. The effect of microbial induced corros...

Pegasus XL CYGNSS Second Launch Attempt

NASA Image and Video Library

2016-12-15

A pathfinder aircraft gains altitude after takeoff from the Skid Strip at Cape Canaveral Air Force Station in Florida. The airplane will provide photographic and video imagery of the Orbital ATK L-1011 Stargazer aircraft carrying a Pegasus XL Rocket with eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. With the aircraft flying off shore, the Pegasus rocket will be released. Five seconds later, the solid propellant engine will ignite and boost the eight hurricane observatories to orbit. The eight CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes.

Pegasus XL CYGNSS Second Launch Attempt

NASA Image and Video Library

2016-12-15

A pathfinder aircraft begins its takeoff from the Skid Strip at Cape Canaveral Air Force Station in Florida. The airplane will provide photographic and video imagery of the Orbital ATK L-1011 Stargazer aircraft carrying a Pegasus XL Rocket with eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. With the aircraft flying off shore, the Pegasus rocket will be released. Five seconds later, the solid propellant engine will ignite and boost the eight hurricane observatories to orbit. The eight CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes.

Pegasus XL CYGNSS Second Launch Attempt

NASA Image and Video Library

2016-12-15

A pathfinder aircraft takes off from the Skid Strip at Cape Canaveral Air Force Station in Florida. The airplane will provide photographic and video imagery of the Orbital ATK L-1011 Stargazer aircraft carrying a Pegasus XL Rocket with eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. With the aircraft flying off shore, the Pegasus rocket will be released. Five seconds later, the solid propellant engine will ignite and boost the eight hurricane observatories to orbit. The eight CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes.

Pegasus XL CYGNSS Second Launch Attempt

NASA Image and Video Library

2016-12-15

A pathfinder aircraft soars high after takeoff from the Skid Strip at Cape Canaveral Air Force Station in Florida. The airplane will provide photographic and video imagery of the Orbital ATK L-1011 Stargazer aircraft carrying a Pegasus XL Rocket with eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. With the aircraft flying off shore, the Pegasus rocket will be released. Five seconds later, the solid propellant engine will ignite and boost the eight hurricane observatories to orbit. The eight CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes.

Turning community wastes into sustainable geothermal energy: The S.E. Geysers effluent pipeline project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dellinger, M.; Allen, E.

A unique public/private partnership of local, state, federal, and corporate stakeholders are constructing the world`s first wastewater-to-electricity system at The Geysers. A rare example of a genuinely {open_quotes}sustainable{close_quote} energy system, three Lake County communities will recycle their treated wastewater effluent through the southeast portion of The Geysers steamfield to produce approximately 625,000 MWh annually from six existing geothermal power plants. In effect, the communities` effluent will produce enough power to indefinitely sustain their electric needs, along with enough extra power for thousands of other California consumers. Because of the project`s unique sponsorship, function, and environmental impacts, its implementation has required:more » (1) preparation of a consolidated state environmental impact report (EIR) and federal environmental impact statement (EIS), and seven related environmental agreements and management plans; (2) acquisition of 25 local, state, and federal permits; (3) negotiation of six federal and state financial assistance agreements; (4) negotiation of six participant agreements on construction, operation, and financing of the project; and (5) acquisition of 163 easements from private land owners for pipeline construction access and ongoing maintenance. The project`s success in efficiently and economically completing these requirements is a model for geothermal innovation and partnering throughout the Pacific Rim and elsewhere internationally.« less

Commercial Mobile Alert Service (CMAS) Alerting Pipeline Taxonomy

DTIC Science & Technology

2012-03-01

for the consumer at the mo- ment but will soon become a commoditized, basic requirement. For example, as the baby boomers grow older, mobile services...Commercial Mobile Alert Service (CMAS) Alerting Pipeline Taxonomy The WEA Project Team March 2012 SPECIAL REPORT CMU/SEI-2012-TR-019 CERT...report presents a taxonomy developed for the Commercial Mobile Alert Service (CMAS). The CMAS Alerting Pipeline Taxonomy is a hierarchical classification

Commissioning of a new helium pipeline

NASA Technical Reports Server (NTRS)

2000-01-01

At the commissioning of a new high-pressure helium pipeline at Kennedy Space Center, participants cut the lines to helium-filled balloons. From left, they are Center Director Roy Bridges; Michael Butchko, president, SGS; Pierre Dufour, president and CEO, Air Liquide America Corporation; David Herst, director, Delta IV Launch Sites; Pamela Gillespie, executive administrator, office of Congressman Dave Weldon; and Col. Samuel Dick, representative of the 45th Space Wing. The nine-mile-long buried pipeline will service launch needs at the new Delta IV Complex 37 at Cape Canaveral Air Force Station. It will also serve as a backup helium resource for Shuttle launches. Nearly one launch's worth of helium will be available in the pipeline to support a Shuttle pad in an emergency. The line originates at the Helium Facility on KSC and terminates in a meter station at the perimeter of the Delta IV launch pad. Others at the ceremony were Jerry Jorgensen, pipeline project manager, Space Gateway Support (SGS), and Ramon Lugo, acting executive director, JPMO.

Commissioning of a new helium pipeline

NASA Technical Reports Server (NTRS)

2000-01-01

At the commissioning of a new high-pressure helium pipeline at Kennedy Space Center, participants watch as helium-filled balloons take to the sky after their lines were cut. From left, they are Center Director Roy Bridges; Michael Butchko, president, SGS; Pierre Dufour, president and CEO, Air Liquide America Corporation; David Herst, director, Delta IV Launch Sites; Pamela Gillespie, executive administrator, office of Congressman Dave Weldon; and Col. Samuel Dick, representative of the 45th Space Wing. The nine-mile-long buried pipeline will service launch needs at the new Delta IV Complex 37 at Cape Canaveral Air Force Station. It will also serve as a backup helium resource for Shuttle launches. Nearly one launch's worth of helium will be available in the pipeline to support a Shuttle pad in an emergency. The line originates at the Helium Facility on KSC and terminates in a meter station at the perimeter of the Delta IV launch pad. Others at the ceremony were Jerry Jorgensen, pipeline project manager, Space Gateway Support (SGS), and Ramon Lugo, acting executive director, JPMO.

77 FR 14010 - Millennium Pipeline Company, LLC; Notice of Availability of the Environmental Assessment for the...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-08

... emergency electrical power generator. Pipeline facilities required for the project include approximately 545 feet of new 36-inch- diameter suction and discharge pipelines which would connect the compressor... pipeline located between the new suction and discharge pipelines. The FERC staff mailed copies of the EA to...

Possible illnesses: assessing the health impacts of the Chad Pipeline Project.

PubMed Central

Leonard, Lori

2003-01-01

Health impact assessments associated with large-scale infrastructure projects, such as the Chad-Cameroon Petroleum Development and Pipeline Project, monitor pre-existing conditions and new diseases associated with particular industries or changes in social organization. This paper suggests that illness self-reports constitute a complementary set of benchmarks to measure the health impacts of these projects, and presents data gathered in ongoing household and health service surveys in Ngalaba, a village near a major oilfield in Chad. In an initial 16-week period of weekly data collection, 363 people reported few of the clinically chronic or asymptomatic conditions expected according to health transition theory, and the overall level of illness reporting was low. Illnesses often were described by symptoms or lay diagnoses. Health care practitioners were consulted rarely; when they were, resources for diagnosis and treatment were limited. Clinically acute, short-duration illnesses (e.g. parasitic infections, toothaches, or hernias) were experienced as chronic conditions and were reported week after week. The low levels of illness reporting and lack of clinically chronic conditions are not taken to mean that rural Chadians are healthy. Rather, the patterns of morbidity reflect a particular local ecology in which health services are organized and care dispensed in ways that limit the possibilities for illness in terms of types of illnesses that can be diagnosed and reported, forms illnesses take, and ways in which illnesses are experienced. Illness self-reports are useful adjuncts to "harder" biological measures in HIAs, particularly in the context of large-scale infrastructure projects with explicit development goals. Rather than providing data on the extent to which harm has been mitigated by corporate, state, and donor activities, self-reports show the possibilities of illness in local contexts. PMID:12894327

In vitro and in vivo evaluation of the probiotic attributes of Lactobacillus kefiranofaciens XL10 isolated from Tibetan kefir grain.

PubMed

Xing, Zhuqing; Tang, Wei; Geng, Weitao; Zheng, Yongna; Wang, Yanping

2017-03-01

Lactobacillus kefiranofaciens XL10, with a high yield of extracellular polysaccharide (EPS), is isolated from Tibetan kefir grain and benefits the health of human beings and has been considered to exhibit probiotic potential in vitro and in vivo. The probiotic function of the strain was studied extensively, viz., acid and bile salt tolerances, cell surface hydrophobicity and autoaggregation, the modulation of gut microbiota, and the distribution and colonization of XL10 in the mouse intestinal tract after oral administration. XL10 could survive 3-h incubation at pH 3.5 and exhibited cell surface hydrophobicity of ∼79.9% and autoaggregation of ∼27.8%. After continuous oral administration of XL10 for 2 weeks, the Bifidobacteriaceae family increased, accompanied by an observable decline in Proteobacteria phyla in the tested mice. Butyrivibrio and Pseudobutyrivibrio, recognized as butyric acid-producing bacteria, could also be detected at day 7 and day 14, respectively. The most abundant community in the mouse gut had formed by day 14. Additionally, we found that XL10 successfully adhered to the mucous tissue and colonized the ileum of the mice based on fluorescence imaging, flow cytometry, and qPCR. Our results suggested that XL10 has excellent probiotic properties and represents an alternative for exploitation in the development of novel functional foods.

Internal Corrosion Detection in Liquids Pipelines

DOT National Transportation Integrated Search

2012-01-01

PHMSA project DTRS56-05-T-0005 "Development of ICDA for Liquid Petroleum Pipelines" led to the development of a Direct Assessment (DA) protocol to prioritize locations of possible internal corrosion. The underlying basis LP-ICDA is simple; corrosion ...

Identification of missing variants by combining multiple analytic pipelines.

PubMed

Ren, Yingxue; Reddy, Joseph S; Pottier, Cyril; Sarangi, Vivekananda; Tian, Shulan; Sinnwell, Jason P; McDonnell, Shannon K; Biernacka, Joanna M; Carrasquillo, Minerva M; Ross, Owen A; Ertekin-Taner, Nilüfer; Rademakers, Rosa; Hudson, Matthew; Mainzer, Liudmila Sergeevna; Asmann, Yan W

2018-04-16

After decades of identifying risk factors using array-based genome-wide association studies (GWAS), genetic research of complex diseases has shifted to sequencing-based rare variants discovery. This requires large sample sizes for statistical power and has brought up questions about whether the current variant calling practices are adequate for large cohorts. It is well-known that there are discrepancies between variants called by different pipelines, and that using a single pipeline always misses true variants exclusively identifiable by other pipelines. Nonetheless, it is common practice today to call variants by one pipeline due to computational cost and assume that false negative calls are a small percent of total. We analyzed 10,000 exomes from the Alzheimer's Disease Sequencing Project (ADSP) using multiple analytic pipelines consisting of different read aligners and variant calling strategies. We compared variants identified by using two aligners in 50,100, 200, 500, 1000, and 1952 samples; and compared variants identified by adding single-sample genotyping to the default multi-sample joint genotyping in 50,100, 500, 2000, 5000 and 10,000 samples. We found that using a single pipeline missed increasing numbers of high-quality variants correlated with sample sizes. By combining two read aligners and two variant calling strategies, we rescued 30% of pass-QC variants at sample size of 2000, and 56% at 10,000 samples. The rescued variants had higher proportions of low frequency (minor allele frequency [MAF] 1-5%) and rare (MAF < 1%) variants, which are the very type of variants of interest. In 660 Alzheimer's disease cases with earlier onset ages of ≤65, 4 out of 13 (31%) previously-published rare pathogenic and protective mutations in APP, PSEN1, and PSEN2 genes were undetected by the default one-pipeline approach but recovered by the multi-pipeline approach. Identification of the complete variant set from sequencing data is the prerequisite of genetic

Building the Pipeline for Hubble Legacy Archive Grism data

NASA Astrophysics Data System (ADS)

Kümmel, M.; Albrecht, R.; Fosbury, R.; Freudling, W.; Haase, J.; Hook, R. N.; Kuntschner, H.; Lombardi, M.; Micol, A.; Rosa, M.; Stoehr, F.; Walsh, J. R.

2008-10-01

The Pipeline for Hubble Legacy Archive Grism data (PHLAG) is currently being developed as an end-to-end pipeline for the Hubble Legacy Archive (HLA). The inputs to PHLAG are slitless spectroscopic HST data with only the basic calibrations from standard HST pipelines applied; the outputs are fully calibrated, Virtuall Observatory-compatible spectra, which will be made available through a static HLA-archive. We give an overview of the various aspects of PHLAG. The pipeline consists of several subcomponents -- data preparation, data retrieval, image combination, object detection, spectral extraction using the aXe software, quality control -- which is discussed in detail. As a pilot project, PHLAG is currently being applied to NICMOS G141 grism data. Examples of G141 spectra reduced with PHLAG are shown.

ORAC-DR: Pipelining With Other People's Code

NASA Astrophysics Data System (ADS)

Economou, Frossie; Bridger, Alan; Wright, Gillian S.; Jenness, Tim; Currie, Malcolm J.; Adamson, Andy

As part of the UKIRT ORAC project, we have developed a pipeline (orac-dr) for driving on-line data reduction using existing astronomical packages as algorithm engines and display tools. The design is modular and extensible on several levels, allowing it to be easily adapted to a wide variety of instruments. Here we briefly review the design, discuss the robustness and speed of execution issues inherent in such pipelines, and address what constitutes a desirable (in terms of ``buy-in'' effort) engine or tool.

Human Factors Analysis of Pipeline Monitoring and Control Operations: Final Technical Report

DOT National Transportation Integrated Search

2008-11-26

The purpose of the Human Factors Analysis of Pipeline Monitoring and Control Operations project was to develop procedures that could be used by liquid pipeline operators to assess and manage the human factors risks in their control rooms that may adv...

Comprehensive investigation into historical pipeline construction costs and engineering economic analysis of Alaska in-state gas pipeline

NASA Astrophysics Data System (ADS)

Rui, Zhenhua

This study analyzes historical cost data of 412 pipelines and 220 compressor stations. On the basis of this analysis, the study also evaluates the feasibility of an Alaska in-state gas pipeline using Monte Carlo simulation techniques. Analysis of pipeline construction costs shows that component costs, shares of cost components, and learning rates for material and labor costs vary by diameter, length, volume, year, and location. Overall average learning rates for pipeline material and labor costs are 6.1% and 12.4%, respectively. Overall average cost shares for pipeline material, labor, miscellaneous, and right of way (ROW) are 31%, 40%, 23%, and 7%, respectively. Regression models are developed to estimate pipeline component costs for different lengths, cross-sectional areas, and locations. An analysis of inaccuracy in pipeline cost estimation demonstrates that the cost estimation of pipeline cost components is biased except for in the case of total costs. Overall overrun rates for pipeline material, labor, miscellaneous, ROW, and total costs are 4.9%, 22.4%, -0.9%, 9.1%, and 6.5%, respectively, and project size, capacity, diameter, location, and year of completion have different degrees of impacts on cost overruns of pipeline cost components. Analysis of compressor station costs shows that component costs, shares of cost components, and learning rates for material and labor costs vary in terms of capacity, year, and location. Average learning rates for compressor station material and labor costs are 12.1% and 7.48%, respectively. Overall average cost shares of material, labor, miscellaneous, and ROW are 50.6%, 27.2%, 21.5%, and 0.8%, respectively. Regression models are developed to estimate compressor station component costs in different capacities and locations. An investigation into inaccuracies in compressor station cost estimation demonstrates that the cost estimation for compressor stations is biased except for in the case of material costs. Overall average

Pegasus XL CYGNSS Second Launch Attempt

NASA Image and Video Library

2016-12-15

Photographed from the F-18 pathfinder aircraft, the Orbital ATK L-1011 Stargazer aircraft is seen flying over the Atlantic Ocean offshore from Daytona Beach, Florida. Attached beneath the aircraft is the Pegasus XL rocket with eight Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. The CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a crucial role in the beginning and intensification of hurricanes.

Pegasus XL CYGNSS Second Launch Attempt

NASA Image and Video Library

2016-12-15

A pathfinder aircraft, at left, prepares for takeoff from the Skid Strip at Cape Canaveral Air Force Station in Florida. The airplane will provide photographic and video imagery of the Orbital ATK L-1011 Stargazer aircraft, in view at right, carrying a Pegasus XL Rocket with eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. With the aircraft flying off shore, the Pegasus rocket will be released. Five seconds later, the solid propellant engine will ignite and boost the eight hurricane observatories to orbit. The eight CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes.

Pegasus XL CYGNSS Second Launch Attempt

NASA Image and Video Library

2016-12-15

A pathfinder aircraft touches down at the Skid Strip at Cape Canaveral Air Force Station in Florida. The airplane provided photographic and video imagery of the Orbital ATK L-1011 Stargazer aircraft carrying a Pegasus XL Rocket with eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. With the aircraft flying off shore, the Pegasus rocket was released at 8:37 a.m. EST. Five seconds later, the solid propellant engine ignited and boosted the eight hurricane observatories to orbit. The eight CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes.

Pegasus XL CYGNSS Second Launch Attempt

NASA Image and Video Library

2016-12-15

A pathfinder aircraft descends for touchdown at the Skid Strip at Cape Canaveral Air Force Station in Florida. The airplane provided photographic and video imagery of the Orbital ATK L-1011 Stargazer aircraft carrying a Pegasus XL Rocket with eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. With the aircraft flying off shore, the Pegasus rocket was released at 8:37 a.m. EST. Five seconds later, the solid propellant engine ignited and boosted the eight hurricane observatories to orbit. The eight CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes.

The trans-Alaska pipeline controversy: Technology, conservation, and the frontier

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coates, P.A.

1991-01-01

The Trans-Alaska Pipeline was the object of perhaps the most passionately fought conservation battle in the U.S. Although numerous authors documented the pipeline construction during its construction, there is, surprisingly, no previous scholarly treatment of this event written by an historian. Coates is an environmental historian who views the most interesting aspect of the controversy to be [open quote]its relationship to earlier engineering projects and technological innovations in Alaska and the debates that accompanied them.[close quotes] Thus, he describes how the conservationist and environmental ideas arose during numerous earlier major Alaskan projects and controversies, including the Alaska Highway (1938-41), Canolmore » Pipeline (1943-45), exploration of Naval Petroleum Reserve Number Four (Pet 4, 1944-1953), DEWline (1953-57), oil development in the Kenai National Moose Range (1957-58), statehood (1958), the creation of the Arctic Wildlife Refuge (1960), Project Chariot (1958-63), and Rampart Dam (1959-67). The history starts with the acquisition of Alaska in 1867 and finishes about the time of the Valdez oil spill in 1989.« less

76 FR 70953 - Pipeline Safety: Safety of Gas Transmission Pipelines

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-16

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration 49 CFR Part 192 [Docket ID PHMSA-2011-0023] RIN 2137-AE72 Pipeline Safety: Safety of Gas Transmission Pipelines AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA); DOT. ACTION: Advance notice of...

Fracture control for the Oman India Pipeline

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bruno, T.V.

1996-12-31

This paper describes the evaluation of the resistance to fracture initiation and propagation for the high-strength, heavy-wall pipe required for the Oman India Pipeline (OIP). It discusses the unique aspects of this pipeline and their influence on fracture control, reviews conventional fracture control design methods, their limitations with regard to the pipe in question, the extent to which they can be utilized for this project, and other approaches being explored. Test pipe of the size and grade required for the OIP show fracture toughness well in excess of the minimum requirements.

Bim directly antagonizes Bcl-xl in doxorubicin-induced prostate cancer cell apoptosis independently of p53.

PubMed

Yang, Min-Chi; Lin, Ru-Wei; Huang, Shih-Bo; Huang, Shin-Yuan; Chen, Wen-Jie; Wang, Shiaw; Hong, Yi-Ren; Wang, Chihuei

2016-01-01

Doxorubicin and other anthracycline compounds exert their anti-cancer effects by causing DNA damage and initiating cell cycle arrest in cancer cells, followed by apoptosis. DNA damage generally activates a p53-mediated pathway to initiate apoptosis by increasing the level of the BH3-only protein, Puma. However, p53-mediated apoptosis in response to DNA damage has not yet been validated in prostate cancers. In the current study, we used LNCaP and PC3 prostate cancer cells, representing wild type p53 and a p53-null model, to determine if DNA damage activates p53-mediated apoptosis in prostate cancers. Our results revealed that PC3 cells were 4 to 8-fold less sensitive than LNCaP cells to doxorubicin-inuced apoptosis. We proved that the differential response of LNCaP and PC3 to doxorubicin was p53-independent by introducing wild-type or dominant negative p53 into PC3 or LNCaP cells, respectively. By comparing several apoptosis-related proteins in both cell lines, we found that Bcl-xl proteins were much more abundant in PC3 cells than in LNCaP cells. We further demonstrated that Bcl-xl protects LNCaP and PC3 cells from doxorubicin-induced apoptosis by using ABT-263, an inhibitor of Bcl-xl, as a single agent or in combination with doxorubicin to treat LNCaP or PC3 cells. Bcl-xl rather than p53, likely contributes to the differential response of LNCaP and PC3 to doxorubicin in apoptosis. Finally, co-immunoprecipitation and siRNA analysis revealed that a BH3-only protein, Bim, is involved in doxorubicin-induced apoptosis by directly counteracting Bcl-xl.

Pipeline bottoming cycle study. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1980-06-01

The technical and economic feasibility of applying bottoming cycles to the prime movers that drive the compressors of natural gas pipelines was studied. These bottoming cycles convert some of the waste heat from the exhaust gas of the prime movers into shaft power and conserve gas. Three typical compressor station sites were selected, each on a different pipeline. Although the prime movers were different, they were similar enough in exhaust gas flow rate and temperature that a single bottoming cycle system could be designed, with some modifications, for all three sites. Preliminary design included selection of the bottoming cycle workingmore » fluid, optimization of the cycle, and design of the components, such as turbine, vapor generator and condensers. Installation drawings were made and hardware and installation costs were estimated. The results of the economic assessment of retrofitting bottoming cycle systems on the three selected sites indicated that profitability was strongly dependent upon the site-specific installation costs, how the energy was used and the yearly utilization of the apparatus. The study indicated that the bottoming cycles are a competitive investment alternative for certain applications for the pipeline industry. Bottoming cycles are technically feasible. It was concluded that proper design and operating practices would reduce the environmental and safety hazards to acceptable levels. The amount of gas that could be saved through the year 2000 by the adoption of bottoming cycles for two different supply projections was estimated as from 0.296 trillion ft/sup 3/ for a low supply projection to 0.734 trillion ft/sup 3/ for a high supply projection. The potential market for bottoming cycle equipment for the two supply projections varied from 170 to 500 units of varying size. Finally, a demonstration program plan was developed.« less

Numerical Simulations For the F-16XL Aircraft Configuration

NASA Technical Reports Server (NTRS)

Elmiligui, Alaa A.; Abdol-Hamid, Khaled; Cavallo, Peter A.; Parlette, Edward B.

2014-01-01

Numerical simulations of flow around the F-16XL are presented as a contribution to the Cranked Arrow Wing Aerodynamic Project International II (CAWAPI-II). The NASA Tetrahedral Unstructured Software System (TetrUSS) is used to perform numerical simulations. This CFD suite, developed and maintained by NASA Langley Research Center, includes an unstructured grid generation program called VGRID, a postprocessor named POSTGRID, and the flow solver USM3D. The CRISP CFD package is utilized to provide error estimates and grid adaption for verification of USM3D results. A subsonic high angle-of-attack case flight condition (FC) 25 is computed and analyzed. Three turbulence models are used in the calculations: the one-equation Spalart-Allmaras (SA), the two-equation shear stress transport (SST) and the ke turbulence models. Computational results, and surface static pressure profiles are presented and compared with flight data. Solution verification is performed using formal grid refinement studies, the solution of Error Transport Equations, and adaptive mesh refinement. The current study shows that the USM3D solver coupled with CRISP CFD can be used in an engineering environment in predicting vortex-flow physics on a complex configuration at flight Reynolds numbers.

Targeting Bcl-2/Bcl-XL induces antitumor activity in uveal melanoma patient-derived xenografts.

PubMed

Némati, Fariba; de Montrion, Catherine; Lang, Guillaume; Kraus-Berthier, Laurence; Carita, Guillaume; Sastre-Garau, Xavier; Berniard, Aurélie; Vallerand, David; Geneste, Olivier; de Plater, Ludmilla; Pierré, Alain; Lockhart, Brian; Desjardins, Laurence; Piperno-Neumann, Sophie; Depil, Stéphane; Decaudin, Didier

2014-01-01

Uveal melanoma (UM) is associated with a high risk of metastases and lack of efficient therapies. Reduced capacity for apoptosis induction by chemotherapies is one obstacle to efficient treatments. Human UM is characterized by high expression of the anti-apoptotic protein Bcl-2. Consequently, regulators of apoptosis such as Bcl-2 family inhibitors may constitute an attractive approach to UM therapeutics. In this aim, we have investigated the efficacy of the Bcl-2/Bcl-XL inhibitor S44563 on 4 UM Patient-Derived Xenografts (PDXs) and derived-cell lines. Four well characterized UM PDXs were used for in vivo experiments. S44563 was administered alone or combined with fotemustine either concomitantly or after the alkylating agent. Bcl-2, Bcl-XL, and Mcl-1 expressions after S44563 administration were evaluated by immunohistochemistry (IHC). S44563 administered alone by at 50 and 100 mg/kg i.p. induced a significant tumour growth inhibition in only one xenograft model with a clear dose effect. However, when S44563 was concomitantly administered with fotemustine, we observed a synergistic activity in 3 out of the 4 tested models. In addition, S44563 administered after fotemustine induced a tumour growth delay in 2 out of 3 tested xenografts. Finally, IHC analyses showed that Bcl-2, Bcl-XL, and Mcl-1 expression were not modified after S44563 administration. The novel anti-apoptotic experimental compound S44563, despite a relative low efficacy when administered alone, increased the efficacy of fotemustine in either concomitant or sequential combinations or indeed subsequent to fotemustine. These data support further exploration of potential therapeutic effect of Bcl-2/Bcl-xl inhibition in human UM.

GI-POP: a combinational annotation and genomic island prediction pipeline for ongoing microbial genome projects.

PubMed

Lee, Chi-Ching; Chen, Yi-Ping Phoebe; Yao, Tzu-Jung; Ma, Cheng-Yu; Lo, Wei-Cheng; Lyu, Ping-Chiang; Tang, Chuan Yi

2013-04-10

Sequencing of microbial genomes is important because of microbial-carrying antibiotic and pathogenetic activities. However, even with the help of new assembling software, finishing a whole genome is a time-consuming task. In most bacteria, pathogenetic or antibiotic genes are carried in genomic islands. Therefore, a quick genomic island (GI) prediction method is useful for ongoing sequencing genomes. In this work, we built a Web server called GI-POP (http://gipop.life.nthu.edu.tw) which integrates a sequence assembling tool, a functional annotation pipeline, and a high-performance GI predicting module, in a support vector machine (SVM)-based method called genomic island genomic profile scanning (GI-GPS). The draft genomes of the ongoing genome projects in contigs or scaffolds can be submitted to our Web server, and it provides the functional annotation and highly probable GI-predicting results. GI-POP is a comprehensive annotation Web server designed for ongoing genome project analysis. Researchers can perform annotation and obtain pre-analytic information include possible GIs, coding/non-coding sequences and functional analysis from their draft genomes. This pre-analytic system can provide useful information for finishing a genome sequencing project. Copyright © 2012 Elsevier B.V. All rights reserved.

78 FR 41395 - NET Mexico Pipeline Partners, LLC: Notice of Intent To Prepare an Environmental Assessment for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-10

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP13-482-000] NET Mexico Pipeline Partners, LLC: Notice of Intent To Prepare an Environmental Assessment for the Proposed NET Mexico... the environmental impacts of the NET Mexico Pipeline Project (Project) involving construction and...

Direct comparison of the FibroScan XL and M probes for assessment of liver fibrosis in obese and nonobese patients.

PubMed

Durango, Esteban; Dietrich, Christian; Seitz, Helmut Karl; Kunz, Cornelia Ursula; Pomier-Layrargues, Gilles T; Duarte-Rojo, Andres; Beaton, Melanie; Elkhashab, Magdy; Myers, Robert P; Mueller, Sebastian

2013-01-01

A novel Fibroscan XL probe has recently been introduced and validated for obese patients, and has a diagnostic accuracy comparable with that of the standard M probe. The aim of this study was to analyze and understand the differences between these two probes in nonobese patients, to identify underlying causes for these differences, and to develop a practical algorithm to translate results for the XL probe to those for the M probe. Both probes were directly compared first in copolymer phantoms of varying stiffness (4.8, 11, and 40 kPa) and then in 371 obese and nonobese patients (body mass index, range 17.2-72.4) from German (n = 129) and Canadian (n = 242) centers. Liver stiffness values for both probes correlated better in phantoms than in patients (r = 0.98 versus 0.82, P < 0.001). Significantly more patients could be measured successfully using the XL probe than the M probe (98.4% versus 85.2%, respectively, P < 0.001) while the M probe produced a smaller interquartile range (21% versus 32%). Failure of the M probe to measure liver stiffness was not only observed in patients with a high body mass index and long skin-liver capsule distance but also in some nonobese patients (n = 10) due to quenching of the signal from subcutaneous fat tissue. In contrast with the phantoms, the XL probe consistently produced approximately 20% lower liver stiffness values in humans compared with the M probe. A long skin-liver capsule distance and a high degree of steatosis were responsible for this discordance. Adjustment of cutoff values for the XL probe (<5.5, 5.5-7, 7-10, and >10 kPa for F0, F1-2, F3, and F4 fibrosis, respectively) significantly improved agreement between the two probes from r = 0.655 to 0.679. Liver stiffness can be measured in significantly more obese and nonobese patients using the XL probe than the M probe. However, the XL probe is less accurate and adjusted cutoff values are required.

The third stage of the Orbital Sciences Pegasus XL rocket is bei

NASA Image and Video Library

2007-04-03

At Vandenberg Air Force Base in California, the Orbital Sciences Pegasus XL rocket is ready for mating to the AIM spacecraft. AIM, which stands for Aeronomy of Ice in the Mesosphere, is being prepared for integrated testing and a flight simulation. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. Launch from the Pegasus XL rocket is scheduled for April 25.

The third stage of the Orbital Sciences Pegasus XL rocket is bei

NASA Image and Video Library

2007-04-03

At Vandenberg Air Force Base in California, a technician mates the AIM spacecraft, at left, to the Orbital Sciences Pegasus XL rocket, at right. AIM, which stands for Aeronomy of Ice in the Mesosphere, is being prepared for integrated testing and a flight simulation. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. Launch from the Pegasus XL rocket is scheduled for April 25.

76 FR 73570 - Pipeline Safety: Miscellaneous Changes to Pipeline Safety Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-29

... pipeline facilities to facilitate the removal of liquids and other materials from the gas stream. These... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration 49 CFR Parts... Changes to Pipeline Safety Regulations AGENCY: Pipeline and Hazardous Materials Safety Administration...

Pipeline welding goes mechanized

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beeson, R.

1999-11-01

Spread four has bugs in the cornfield--but not to worry. The bug referred to here is a mechanized welding bug, specifically a single welding head, computer-aided gas metal arc (GMAW) system from CRC-Evans Automatic Welding powered by a Miller Electric XMT{reg{underscore}sign} 304 inverter-based welding machine. The bug operator and owner of 32 inverters is Welded Construction, L.P., of Perrysburgh, Ohio. Spread four is a 147-mile stretch of the Alliance Pipeline system (Alliance) cutting through the cornfields of northeast Iowa. While used successfully in Canada and Europe for onshore and offshore pipeline construction for 30 years, this is the first large-scalemore » use of mechanized welding in the US on a cross-country pipeline. On longer, larger-diameter and thicker-wall pipe projects--the Alliance mainline has 1,844 miles of pipe, most of it 36-in. diameter with a 0.622-in. wall thickness--mechanized GMAW offers better productivity than manual shielded metal arc welding (SMAW). In addition, high-strength steels, such as the API 5L Grade X70 pipe used on the Alliance, benefit from the low-hydrogen content of certain solid and tubular wire electrodes.« less

[A comparison of rebound tonometry (ICare) with TonoPenXL and Goldmann applanation tonometry].

PubMed

Schreiber, W; Vorwerk, C K; Langenbucher, A; Behrens-Baumann, W; Viestenz, A

2007-04-01

Goldmann applanation tonometry and dynamic contour tonometry (PASCAL) are two well established slit lamp mounted tonometric methods. Intraocular pressure measurement in bedridden patients and children is often only possible using hand held tonometers (TonoPenXL, Perkins tonometer, Draeger tonometer). This study was performed to evaluate the hand held ICare tonometer, which is based on the rebound method. A total of 102 eyes were examined by two highly experienced ophthalmologists for: 1) ophthalmological status, 2) central corneal power (Zeiss IOL-Master), 3) central corneal thickness (Tomey ultrasound pachymetry, five successive measurements, SD<5%), 4) intraocular pressure (IOP) measurement with the Goldmann applantation tonometer (GAT) 1x, 5) TonoPenXL (1x), 6) ICare with three successive measurement series of 6 single measurements. The mean IOP(GAT) was 13.2+/-3.0 mmHg compared with the mean IOP(TonoPenXL) (13.4+/-3.1 mmHg) and with the IOP(ICare) (mean value of first measurement series: 13.4+/-3.1 mmHg). The series of measurements with the ICare showed a tonography effect (decrease of IOP from 14.6 mmHg at the first measurement and 14.2 mmHg at the second to 14.0 at the third measurement). The ICare-measurements were highly reliable (Cronbach's alpha=0.974) and showed a good correlation between the measurement series (r=0.592-0.642; p<0.001). There was a great intra-individual variability of up to 17 mmHg between the GAT, TonoPenXL and ICare methods. The ICare tonometer is easy to handle and high reliability. The data are comparable with those from the Goldmann tonometer. A tonography effect of 0.6 mmHg in the successive measurement series was found.

Study on Resources Assessment of Coal Seams covered by Long-Distance Oil & Gas Pipelines

NASA Astrophysics Data System (ADS)

Han, Bing; Fu, Qiang; Pan, Wei; Hou, Hanfang

2018-01-01

The assessment of mineral resources covered by construction projects plays an important role in reducing the overlaying of important mineral resources and ensuring the smooth implementation of construction projects. To take a planned long-distance gas pipeline as an example, the assessment method and principles for coal resources covered by linear projects are introduced. The areas covered by multiple coal seams are determined according to the linear projection method, and the resources covered by pipelines directly and indirectly are estimated by using area segmentation method on the basis of original blocks. The research results can provide references for route optimization of projects and compensation for mining right..

Introduction: Prediction of F-16XL Flight Flow Physics

NASA Technical Reports Server (NTRS)

Lamar, John E.

2009-01-01

This special section is the result of fruitful endeavors by an international group of researchers in industry, government laboratories and university-led efforts to improve the technology readiness level of their CFD solvers through comparisons with flight data collected on the F-16XL-1 aircraft at a variety of test conditions. These 1996 flight data were documented and detailed the flight-flow physics of this aircraft through surface tufts and pressures, boundary-layer rakes and skin-friction measurements. The flight project was called the Cranked Wing Aerodynamics Project (CAWAP), due to its leading-edge sweep crank (70 degrees inboard, 50 degrees outboard), and served as a basis for the International comparisons to be made, called CAWAPI. This highly focused effort was one of two vortical flow studies facilitated by the NATO Research and Technology Organization through its Applied Vehicle Panel with a title of Understanding and Modeling Vortical Flows to Improve the Technology Readiness Level for Military Aircraft. It was given a task group number of AVT-113 and had an official start date of Spring 2003. The companion part of this task group dealt with fundamentals of vortical flow from both an experimental and numerical perspective on an analytically describable 65 degree delta-wing model for which much surface pressure data had already been measured at NASA Langley Research Center at a variety of Mach and Reynolds numbers and is called the Vortex Flow Experiment - 2 (VFE-2). These two parts or facets helped one another in understanding the predictions and data that had been or were being collected.

United States petroleum pipelines: An empirical analysis of pipeline sizing

NASA Astrophysics Data System (ADS)

Coburn, L. L.

1980-12-01

The undersizing theory hypothesizes that integrated oil companies have a strong economic incentive to size the petroleum pipelines they own and ship over in a way that means that some of the demand must utilize higher cost alternatives. The DOJ theory posits that excess or monopoly profits are earned due to the natural monopoly characteristics of petroleum pipelines and the existence of market power in some pipelines at either the upstream or downstream market. The theory holds that independent petroleum pipelines owned by companies not otherwise affiliated with the petroleum industry (independent pipelines) do not have these incentives and all the efficiencies of pipeline transportation are passed to the ultimate consumer. Integrated oil companies on the other hand, keep these cost efficiencies for themselves in the form of excess profits.

78 FR 15715 - Excelerate Liquefaction Solutions I, LLC; Lavaca Bay Pipeline System, LLC; Notice of Intent To...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-12

... natural gas from existing pipeline systems to the LNG terminal facilities. The Project would be... room, warehouse, and shop. Pipeline Header System: A 29-mile-long, 42-inch-diameter natural gas pipeline extending northward from the shoreside facilities to nine natural gas interconnects southwest of...

BCL-2 and BCL-XL expression are down-regulated in benign prostate hyperplasia nodules and not affected by finasteride and/or celecoxib

PubMed Central

Li, Feng; Pascal, Laura E; Zhou, Jianhua; Zhou, Yibin; Wang, Ke; Parwani, Anil V; Dhir, Rajiv; Guo, Peng; He, Dalin; Nelson, Joel B; Wang, Zhou

2018-01-01

The mechanisms involved in the development of benign prostatic hyperplasia (BPH) are poorly understood. One potential mechanism involved in BPH pathogenesis may involve altered expression of genes related to apoptosis and proliferation because reduced cell death and increased proliferation are thought to contribute to prostatic enlargement. This study examined the expression of B-cell lymphoma 2 (BCL-2) and B-cell lymphoma-extra large (BCL-XL), two important anti-apoptosis factors that are also capable of inhibiting cell proliferation via accelerated G1 arrest or delayed G1/S transition, using immunostaining in simple prostatectomy BPH specimens from patients naïve to androgen manipulation. Since androgens and inflammation are thought to play important roles in BPH pathogenesis, we tested the effect of inhibiting 5a-reductase and/or COX-2 on the expression of BCL-2 and BCL-XL in BPH specimens from prostate cancer patients with BPH. These patients had no prior use of chronic NSAIDs and/or 5a-reductase inhibitors and were treated with celecoxib, finasteride, celecoxib plus finasteride or no treatment for 28 consecutive days prior to surgery. In all specimens, BCL-2 and BCL-XL staining was evident in both luminal and basal epithelial cells, with more intense staining in basal cells. Both luminal and basal cells exhibited decreased BCL-2 and BCL-XL staining in BPH nodules compared to the surrounding normal prostatic tissues. In prostate cancer patients with BPH, celecoxib and/or finasteride did not affect the expression of BCL-2 and BCL-XL in luminal or basal cells in BPH nodules and normal adjacent tissues. These results suggest that BCL-2 and BCL-XL may act as anti-proliferative factors in BPH pathogenesis, and the effect of celecoxib and/or finasteride on BPH is unlikely mediated through modulating BCL-2 and BCL-XL signaling. PMID:29531971

F-16XL ship #1 - CAWAP outboard rakes #7 and inboard rack #3

NASA Technical Reports Server (NTRS)

1996-01-01

This photo shows the #7 outboard rake and the #3 inboard rake on the left wing of NASA's single-seat F-16XL (ship #1) used for the Cranked-Arrow Wing Aerodynamic Project (CAWAP) at Dryden Flight Research Center, Edwards, California. The modified airplane features a delta 'cranked-arrow' wing with strips of tubing along the leading edge to the trailing edge to sense static on the wing and obtain pressure distribution data. The right wing receives data on pressure distribution and the left wing has three types of instrumentation - preston tubes to measure local skin friction, boundary layer rakes to measure boundary layer profiles (the layer where the air interacts with the surfaces of a moving aircraft), and hot films to determine boundary layer transition locations. The first flight of CAWAP occurred on November 21, 1995, and the test program ended in April 1996.

KSC-20161214-JBS-MH-01-0001-L_1011_Pegasus_XL_CYGNSS-3139565_HEVC

NASA Image and Video Library

2016-12-14

The Orbital ATK L-1011 Stargazer aircraft is at the Skid Strip at Cape Canaveral Air Force Station in Florida. Attached beneath the Stargazer is the Orbital ATK Pegasus XL with NASA's Cyclone Global Navigation Satellite System (CYGNSS) on board. CYGNSS was processed and prepared for its mission at Vandenberg Air Force Base in California. CYGNSS is scheduled for its airborne launch aboard the Pegasus XL rocket from the Skid Strip on Dec. 15. CYGNSS will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a critical role in the beginning and intensification of hurricanes.

The third stage of the Orbital Sciences Pegasus XL rocket is bei

NASA Image and Video Library

2007-04-03

At Vandenberg Air Force Base in California, the third stage of the Orbital Sciences Pegasus XL rocket is being mated to the AIM spacecraft, at right. AIM, which stands for Aeronomy of Ice in the Mesosphere, is being prepared for integrated testing and a flight simulation. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. Launch from the Pegasus XL rocket is scheduled for April 25.

75 FR 13342 - Pipeline Safety: Workshop on Distribution Pipeline Construction

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-19

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket ID... natural gas distribution construction. Natural gas distribution pipelines are subject to a unique subset... distribution pipeline construction practices. This workshop will focus solely on natural gas distribution...

F-16XL ship #1 wing close-up showing boundary layer detection Preston tubes

NASA Technical Reports Server (NTRS)

1995-01-01

This photo shows the boundary layer Preston tubes mounted on the left wing of NASA's single-seat F-16XL (ship #1) used for the Cranked-Arrow Wing Aerodynamic Project (CAWAP) at Dryden Flight Research Center, Edwards, California. The modified airplane features a delta 'cranked-arrow' wing with strips of tubing along the leading edge to the trailing edge to sense static on the wing and obtain pressure distribution data. The right wing receives data on pressure distribution and the left wing has three types of instrumentation - preston tubes to measure local skin friction, boundary layer rakes to measure boundary layer profiles (the layer where the air interacts with the surfaces of a moving aircraft), and hot films to determine boundary layer transition locations. The first flight of CAWAP occurred on November 21, 1995, and the test program ended in April 1996.

Pegasus XL CYGNSS Launch Attempt; Scrubbed - Take Off

NASA Image and Video Library

2016-12-12

An Orbital ATK L-1011 Stargazer aircraft carrying a Pegasus XL Rocket with eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft takes off from the Skid Strip at Cape Canaveral Air Force Station, Florida. With the aircraft flying off shore, the Pegasus rocket will be released. Five seconds later, the solid propellant engine will ignite and boost the eight hurricane observatories to orbit. The eight CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes.

A graph-based approach for designing extensible pipelines

PubMed Central

2012-01-01

Background In bioinformatics, it is important to build extensible and low-maintenance systems that are able to deal with the new tools and data formats that are constantly being developed. The traditional and simplest implementation of pipelines involves hardcoding the execution steps into programs or scripts. This approach can lead to problems when a pipeline is expanding because the incorporation of new tools is often error prone and time consuming. Current approaches to pipeline development such as workflow management systems focus on analysis tasks that are systematically repeated without significant changes in their course of execution, such as genome annotation. However, more dynamism on the pipeline composition is necessary when each execution requires a different combination of steps. Results We propose a graph-based approach to implement extensible and low-maintenance pipelines that is suitable for pipeline applications with multiple functionalities that require different combinations of steps in each execution. Here pipelines are composed automatically by compiling a specialised set of tools on demand, depending on the functionality required, instead of specifying every sequence of tools in advance. We represent the connectivity of pipeline components with a directed graph in which components are the graph edges, their inputs and outputs are the graph nodes, and the paths through the graph are pipelines. To that end, we developed special data structures and a pipeline system algorithm. We demonstrate the applicability of our approach by implementing a format conversion pipeline for the fields of population genetics and genetic epidemiology, but our approach is also helpful in other fields where the use of multiple software is necessary to perform comprehensive analyses, such as gene expression and proteomics analyses. The project code, documentation and the Java executables are available under an open source license at http://code.google.com/p/dynamic-pipeline

Kepler Science Operations Center Pipeline Framework

NASA Technical Reports Server (NTRS)

Klaus, Todd C.; McCauliff, Sean; Cote, Miles T.; Girouard, Forrest R.; Wohler, Bill; Allen, Christopher; Middour, Christopher; Caldwell, Douglas A.; Jenkins, Jon M.

2010-01-01

The Kepler mission is designed to continuously monitor up to 170,000 stars at a 30 minute cadence for 3.5 years searching for Earth-size planets. The data are processed at the Science Operations Center (SOC) at NASA Ames Research Center. Because of the large volume of data and the memory and CPU-intensive nature of the analysis, significant computing hardware is required. We have developed generic pipeline framework software that is used to distribute and synchronize the processing across a cluster of CPUs and to manage the resulting products. The framework is written in Java and is therefore platform-independent, and scales from a single, standalone workstation (for development and research on small data sets) to a full cluster of homogeneous or heterogeneous hardware with minimal configuration changes. A plug-in architecture provides customized control of the unit of work without the need to modify the framework itself. Distributed transaction services provide for atomic storage of pipeline products for a unit of work across a relational database and the custom Kepler DB. Generic parameter management and data accountability services are provided to record the parameter values, software versions, and other meta-data used for each pipeline execution. A graphical console allows for the configuration, execution, and monitoring of pipelines. An alert and metrics subsystem is used to monitor the health and performance of the pipeline. The framework was developed for the Kepler project based on Kepler requirements, but the framework itself is generic and could be used for a variety of applications where these features are needed.

Direct comparison of the FibroScan XL and M probes for assessment of liver fibrosis in obese and nonobese patients

PubMed Central

Durango, Esteban; Dietrich, Christian; Seitz, Helmut Karl; Kunz, Cornelia Ursula; Pomier-Layrargues, Gilles T; Duarte-Rojo, Andres; Beaton, Melanie; Elkhashab, Magdy; Myers, Robert P; Mueller, Sebastian

2013-01-01

Background A novel Fibroscan XL probe has recently been introduced and validated for obese patients, and has a diagnostic accuracy comparable with that of the standard M probe. The aim of this study was to analyze and understand the differences between these two probes in nonobese patients, to identify underlying causes for these differences, and to develop a practical algorithm to translate results for the XL probe to those for the M probe. Methods and results Both probes were directly compared first in copolymer phantoms of varying stiffness (4.8, 11, and 40 kPa) and then in 371 obese and nonobese patients (body mass index, range 17.2–72.4) from German (n = 129) and Canadian (n = 242) centers. Liver stiffness values for both probes correlated better in phantoms than in patients (r = 0.98 versus 0.82, P < 0.001). Significantly more patients could be measured successfully using the XL probe than the M probe (98.4% versus 85.2%, respectively, P < 0.001) while the M probe produced a smaller interquartile range (21% versus 32%). Failure of the M probe to measure liver stiffness was not only observed in patients with a high body mass index and long skin-liver capsule distance but also in some nonobese patients (n = 10) due to quenching of the signal from subcutaneous fat tissue. In contrast with the phantoms, the XL probe consistently produced approximately 20% lower liver stiffness values in humans compared with the M probe. A long skin-liver capsule distance and a high degree of steatosis were responsible for this discordance. Adjustment of cutoff values for the XL probe (<5.5, 5.5–7, 7–10, and >10 kPa for F0, F1–2, F3, and F4 fibrosis, respectively) significantly improved agreement between the two probes from r = 0.655 to 0.679. Conclusion Liver stiffness can be measured in significantly more obese and nonobese patients using the XL probe than the M probe. However, the XL probe is less accurate and adjusted cutoff values are required. PMID:24696623

75 FR 63774 - Pipeline Safety: Safety of On-Shore Hazardous Liquid Pipelines

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-18

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration 49 CFR Part... Pipelines AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), Department of... Gas Pipeline Safety Act of 1968, Public Law 90-481, delegated to DOT the authority to develop...

77 FR 61825 - Pipeline Safety: Notice of Public Meeting on Pipeline Data

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-11

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket ID... program performance measures for gas distribution, gas transmission, and hazardous liquids pipelines. The... distribution pipelines (49 CFR 192.1007(e)), gas transmission pipelines (49 CFR 192.945) and hazardous liquids...

76 FR 303 - Pipeline Safety: Safety of On-Shore Hazardous Liquid Pipelines

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-04

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration 49 CFR Part 195 [Docket ID PHMSA-2010-0229] RIN 2137-AE66 Pipeline Safety: Safety of On-Shore Hazardous Liquid Pipelines AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice of...

Digital Mapping of Buried Pipelines with a Dual Array System

DOT National Transportation Integrated Search

2005-03-01

The project carried out under this agreement, which was informally called the "Dual Array Project" (the term we will use in this report), was part of the research efforts at the Office of Pipeline Safety at U.S. DOT, and was one of seven contracts aw...

Development and Applications of Pipeline Steel in Long-Distance Gas Pipeline of China

NASA Astrophysics Data System (ADS)

Chunyong, Huo; Yang, Li; Lingkang, Ji

In past decades, with widely utilizing of Microalloying and Thermal Mechanical Control Processing (TMCP) technology, the good matching of strength, toughness, plasticity and weldability on pipeline steel has been reached so that oil and gas pipeline has been greatly developed in China to meet the demand of strong domestic consumption of energy. In this paper, development history of pipeline steel and gas pipeline in china is briefly reviewed. The microstructure characteristic and mechanical performance of pipeline steel used in some representative gas pipelines of china built in different stage are summarized. Through the analysis on the evolution of pipeline service environment, some prospective development trend of application of pipeline steel in China is also presented.

Interaction between Na-K-ATPase and Bcl-2 proteins BclXL and Bak.

PubMed

Lauf, Peter K; Alqahtani, Tariq; Flues, Karin; Meller, Jaroslaw; Adragna, Norma C

2015-01-01

In silico analysis predicts interaction between Na-K-ATPase (NKA) and Bcl-2 protein canonical BH3- and BH1-like motifs, consistent with NKA inhibition by the benzo-phenanthridine alkaloid chelerythrine, a BH3 mimetic, in fetal human lens epithelial cells (FHLCs) (Lauf PK, Heiny J, Meller J, Lepera MA, Koikov L, Alter GM, Brown TL, Adragna NC. Cell Physiol Biochem 31: 257-276, 2013). This report establishes proof of concept: coimmunoprecipitation and immunocolocalization showed unequivocal and direct physical interaction between NKA and Bcl-2 proteins. Specifically, NKA antibodies (ABs) coimmunoprecipitated BclXL (B-cell lymphoma extra large) and BAK (Bcl-2 antagonist killer) proteins in FHLCs and A549 lung cancer cells. In contrast, both anti-Bcl-2 ABs failed to pull down NKA. Notably, the molecular mass of BAK1 proteins pulled down by NKA and BclXL ABs appeared to be some 4-kDa larger than found in input monomers. In silico analysis predicts these higher molecular mass BAK1 proteins as alternative splicing variants, encoding 42 amino acid (aa) larger proteins than the known 211-aa long canonical BAK1 protein. These BAK1 variants may constitute a pool separate from that forming mitochondrial pores by specifically interacting with NKA and BclXL proteins. We propose a NKA-Bcl-2 protein ternary complex supporting our hypothesis for a special sensor role of NKA in Bcl-2 protein control of cell survival and apoptosis. Copyright © 2015 the American Physiological Society.

Frequency Spectrum Method-Based Stress Analysis for Oil Pipelines in Earthquake Disaster Areas

PubMed Central

Wu, Xiaonan; Lu, Hongfang; Huang, Kun; Wu, Shijuan; Qiao, Weibiao

2015-01-01

When a long distance oil pipeline crosses an earthquake disaster area, inertial force and strong ground motion can cause the pipeline stress to exceed the failure limit, resulting in bending and deformation failure. To date, researchers have performed limited safety analyses of oil pipelines in earthquake disaster areas that include stress analysis. Therefore, using the spectrum method and theory of one-dimensional beam units, CAESAR II is used to perform a dynamic earthquake analysis for an oil pipeline in the XX earthquake disaster area. This software is used to determine if the displacement and stress of the pipeline meet the standards when subjected to a strong earthquake. After performing the numerical analysis, the primary seismic action axial, longitudinal and horizontal displacement directions and the critical section of the pipeline can be located. Feasible project enhancement suggestions based on the analysis results are proposed. The designer is able to utilize this stress analysis method to perform an ultimate design for an oil pipeline in earthquake disaster areas; therefore, improving the safe operation of the pipeline. PMID:25692790

Frequency spectrum method-based stress analysis for oil pipelines in earthquake disaster areas.

PubMed

Wu, Xiaonan; Lu, Hongfang; Huang, Kun; Wu, Shijuan; Qiao, Weibiao

2015-01-01

When a long distance oil pipeline crosses an earthquake disaster area, inertial force and strong ground motion can cause the pipeline stress to exceed the failure limit, resulting in bending and deformation failure. To date, researchers have performed limited safety analyses of oil pipelines in earthquake disaster areas that include stress analysis. Therefore, using the spectrum method and theory of one-dimensional beam units, CAESAR II is used to perform a dynamic earthquake analysis for an oil pipeline in the XX earthquake disaster area. This software is used to determine if the displacement and stress of the pipeline meet the standards when subjected to a strong earthquake. After performing the numerical analysis, the primary seismic action axial, longitudinal and horizontal displacement directions and the critical section of the pipeline can be located. Feasible project enhancement suggestions based on the analysis results are proposed. The designer is able to utilize this stress analysis method to perform an ultimate design for an oil pipeline in earthquake disaster areas; therefore, improving the safe operation of the pipeline.

The third stage of the Orbital Sciences Pegasus XL rocket is bei

NASA Image and Video Library

2007-04-03

At Vandenberg Air Force Base in California, technicians prepare to mate the AIM spacecraft (at left) to the SoftRide isolation system on the Orbital Sciences Pegasus XL rocket. The Cosmic Dust Experiment surfaces can be clearly seen as 12 rectangular areas on the aft portion of the spacecraft. AIM, which stands for Aeronomy of Ice in the Mesosphere, is being prepared for integrated testing and a flight simulation. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. Launch from the Pegasus XL rocket is scheduled for April 25.

Gathering pipeline methane emissions in Fayetteville shale pipelines and scoping guidelines for future pipeline measurement campaigns

DOE PAGES

Zimmerle, Daniel J.; Pickering, Cody K.; Bell, Clay S.; ...

2017-11-24

Gathering pipelines, which transport gas from well pads to downstream processing, are a sector of the natural gas supply chain for which little measured methane emissions data are available. This study performed leak detection and measurement on 96 km of gathering pipeline and the associated 56 pigging facilities and 39 block valves. The study found one underground leak accounting for 83% (4.0 kg CH 4/hr) of total measured emissions. Methane emissions for the 4684 km of gathering pipeline in the study area were estimated at 402 kg CH 4/hr [95 to 1065 kg CH 4/hr, 95% CI], or 1% [0.2%more » to 2.6%] of all methane emissions measured during a prior aircraft study of the same area. Emissions estimated by this study fall within the uncertainty range of emissions estimated using emission factors from EPA's 2015 Greenhouse Inventory and study activity estimates. While EPA's current inventory is based upon emission factors from distribution mains measured in the 1990s, this study indicates that using emission factors from more recent distribution studies could significantly underestimate emissions from gathering pipelines. To guide broader studies of pipeline emissions, we also estimate the fraction of the pipeline length within a basin that must be measured to constrain uncertainty of pipeline emissions estimates to within 1% of total basin emissions. The study provides both substantial insight into the mix of emission sources and guidance for future gathering pipeline studies, but since measurements were made in a single basin, the results are not sufficiently representative to provide methane emission factors at the regional or national level.« less

Gathering pipeline methane emissions in Fayetteville shale pipelines and scoping guidelines for future pipeline measurement campaigns

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zimmerle, Daniel J.; Pickering, Cody K.; Bell, Clay S.

Gathering pipelines, which transport gas from well pads to downstream processing, are a sector of the natural gas supply chain for which little measured methane emissions data are available. This study performed leak detection and measurement on 96 km of gathering pipeline and the associated 56 pigging facilities and 39 block valves. The study found one underground leak accounting for 83% (4.0 kg CH 4/hr) of total measured emissions. Methane emissions for the 4684 km of gathering pipeline in the study area were estimated at 402 kg CH 4/hr [95 to 1065 kg CH 4/hr, 95% CI], or 1% [0.2%more » to 2.6%] of all methane emissions measured during a prior aircraft study of the same area. Emissions estimated by this study fall within the uncertainty range of emissions estimated using emission factors from EPA's 2015 Greenhouse Inventory and study activity estimates. While EPA's current inventory is based upon emission factors from distribution mains measured in the 1990s, this study indicates that using emission factors from more recent distribution studies could significantly underestimate emissions from gathering pipelines. To guide broader studies of pipeline emissions, we also estimate the fraction of the pipeline length within a basin that must be measured to constrain uncertainty of pipeline emissions estimates to within 1% of total basin emissions. The study provides both substantial insight into the mix of emission sources and guidance for future gathering pipeline studies, but since measurements were made in a single basin, the results are not sufficiently representative to provide methane emission factors at the regional or national level.« less

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-17

In a clean-room environment at North Vandenberg Air Force Base, technicians look at part of the AIM spacecraft. AIM will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-17

In a clean-room environment at North Vandenberg Air Force Base, technicians look at an area of the AIM spacecraft. AIM will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-17

In a clean-room environment at North Vandenberg Air Force Base, technicians work on the AIM spacecraft. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

77 FR 34123 - Pipeline Safety: Public Meeting on Integrity Management of Gas Distribution Pipelines

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-08

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2012-0100] Pipeline Safety: Public Meeting on Integrity Management of Gas Distribution Pipelines AGENCY: Office of Pipeline Safety, Pipeline and Hazardous Materials Safety Administration, DOT. ACTION...

Cellular maturity and apoptosis in human sperm: creatine kinase, caspase-3 and Bcl-XL levels in mature and diminished maturity sperm.

PubMed

Cayli, Sevil; Sakkas, Denny; Vigue, Lynne; Demir, Ramazan; Huszar, Gabor

2004-05-01

The relationship between human sperm maturity and apoptosis is of interest because of the persistence of immature sperm in ejaculates in spite of various apoptotic processes during spermatogenesis. We assessed sperm maturity by HspA2 chaperone levels, and plasma membrane maturity by sperm binding to immobilized hyaluronic acid (HA). We also utilized objective morphometry. Sperm were stained with three antibody combinations: active caspase-3/creatine kinase (CK, a marker of cytoplasmic retention), caspase-3/the antiapoptotic Bcl-(XL), and CK/Bcl-(XL). In semen, 13% of sperm stained with CK, caspase-3 or Bcl-(XL), and 28% had stained with two markers. In the mature HA-bound sperm fraction, <4% were single- or double-stained. Regarding sperm regions, CK staining, whether alone or as double staining, occurred in the head and midpiece (15-20%), whereas caspase-3 and Bcl-(XL) were primarily (>80% of sperm) in the midpiece. Morphometrical attributes of clear, single- and double-stained sperm, in line with their more pronounced maturation arrest, showed an incremental increase in head size (due to cytoplasmic retention) and shorter tail length. We hypothesize that during faulty sperm development, three alternatives may occur: (i) elimination of aberrant germ cells by apoptosis; (ii) in surviving immature cells, caspase-3 is activated, and in response the antiapoptotic Bcl-(XL), and perhaps HspA2, provide protection; (iii) in a third type of immature sperm, in addition to the CK, caspase-3 and Bcl-(XL) expression, there are related manifestations of increased head size and shorter tail length. Thus, immature sperm may vary in the type of developmental arrest and in protection mechanisms for apoptosis. These variations are likely to explain the persistence of immature sperm in the ejaculate.

77 FR 34380 - Explorer Pipeline Company; Notice of Amendment to Petition for Declaratory Order

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-11

... Petition, Explorer described the Diluent Extension Project as involving the construction of a new pipeline..., pursuant to Rule 215 of the Commission's Rules of Practice and Procedure, 18 CFR 385.215 (2011), Explorer Pipeline Company (Explorer) filed an amendment to its March 23, 2012 Petition to the Federal Energy...

75 FR 5244 - Pipeline Safety: Integrity Management Program for Gas Distribution Pipelines; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-02

... Management Program for Gas Distribution Pipelines; Correction AGENCY: Pipeline and Hazardous Materials Safety... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration 49 CFR Part... Regulations to require operators of gas distribution pipelines to develop and implement integrity management...

Massively Parallel Sequencing of Forensic STRs Using the Ion Chef™ and the Ion S5™ XL Systems.

PubMed

Wang, Le; Chen, Man; Wu, Bo; Liu, Yi-Cheng; Zhang, Guang-Feng; Jiang, Li; Xu, Xiu-Lan; Zhao, Xing-Chun; Ji, An-Quan; Ye, Jian

2018-03-01

Next-generation sequencing (NGS) has been used to genotype forensic short tandem repeat (STR) markers for individual identification and kinship analysis. STR data from several NGS platforms have been published, but forensic application trials using the Ion S5™ XL system have not been reported. In this work, we report sensitivity, reproducibility, mixture, simulated degradation, and casework sample data on the Ion Chef™ and S5™ XL systems using an early access 25-plex panel. Sensitivity experiments showed that over 97% of the alleles were detectable with down to 62 pg input of genomic DNA. In mixture studies, alleles from minor contributors were correctly assigned at 1:9 and 9:1 ratios. NGS successfully gave 12 full genotype results from 13 challenging casework samples, compared with five full results using the CE platform. In conclusion, the Ion Chef™ and the Ion S5™ XL systems provided an alternative and promising approach for forensic STR genotyping. © 2018 American Academy of Forensic Sciences.

Sequencing on the SOLiD 5500xl System - in-depth characterization of the GC bias.

PubMed

Roeh, Simone; Weber, Peter; Rex-Haffner, Monika; Deussing, Jan M; Binder, Elisabeth B; Jakovcevski, Mira

2017-07-04

Different types of sequencing biases have been described and subsequently improved for a variety of sequencing systems, mostly focusing on the widely used Illumina systems. Similar studies are missing for the SOLiD 5500xl system, a sequencer which produced many data sets available to researchers today. Describing and understanding the bias is important to accurately interpret and integrate these published data in various ongoing research projects. We report a particularly strong GC bias for this sequencing system when analyzing a defined gDNA mix of 5 microbes with a wide range of different GC contents (20-72%) when comparing to the expected distribution and Illumina MiSeq data from the same DNA pool. Since we observed this bias already under PCR-free conditions, changing the PCR conditions during library preparation - a common strategy to handle bias in the Illumina system - was not relevant. Source of the bias appeared to be an uneven heat distribution during the SOLiD emulsion PCR (ePCR) - for enrichment of libraries prior loading - since ePCR in either small pouches or in 96-well plates improved the GC bias. Sequencing of chromatin immunoprecipitated DNA (ChIP-seq) is a common approach in epigenetics. ChIP-seq of the mixed source histone mark H3K9ac (acetyl Histone H3 lysine 9), typically found on promoter regions and on gene bodies, including CpG islands, performed on a SOLiD 5500xl machine, resulted in major loss of reads at GC rich loci (GC content ≥ 62%), not explained by low sequencing depth. This was improved with adaptations of the ePCR.

Oman India Pipeline: An operational repair strategy based on a rational assessment of risk

DOE Office of Scientific and Technical Information (OSTI.GOV)

German, P.

1996-12-31

This paper describes the development of a repair strategy for the operational phase of the Oman India Pipeline based upon the probability and consequences of a pipeline failure. Risk analyses and cost benefit analyses performed provide guidance on the level of deepwater repair development effort appropriate for the Oman India Pipeline project and identifies critical areas toward which more intense development effort should be directed. The risk analysis results indicate that the likelihood of a failure of the Oman India Pipeline during its 40-year life is low. Furthermore, the probability of operational failure of the pipeline in deepwater regions ismore » extremely low, the major proportion of operational failure risk being associated with the shallow water regions.« less

F-16XL ship #1 - CAWAP boundary layer hot film, left wing

NASA Technical Reports Server (NTRS)

1996-01-01

This photo shows the boundary layer hot film on the left wing of NASA's single-seat F-16XL (ship #1) used for the Cranked-Arrow Wing Aerodynamic Project (CAWAP) at Dryden Flight Research Center, Edwards, California. Hot film is used to measure temperature changes on a surface. The modified airplane features a delta 'cranked-arrow' wing with strips of tubing along the leading edge to the trailing edge to sense static on the wing and obtain pressure distribution data. The right wing receives data on pressure distribution and the left wing has three types of instrumentation - preston tubes to measure local skin friction, boundary layer rakes to measure boundary layer profiles (the layer where the air interacts with the surfaces of a moving aircraft), and hot films to determine boundary layer transition locations. The program also gathered aero data on two wing planforms for NASA's High Speed Research Program. The first flight of CAWAP occurred on November 21, 1995, and the test program ended in April 1996.

Removal of copper (II) from aqueous solutions by flotation using polyaluminum chloride silicate (PAX-XL60 S) as coagulant and carbonate ion as activator.

PubMed

Ghazy, S E; Mahmoud, I A; Ragab, A H

2006-01-01

Flotation is a separation technology for removing toxic heavy metal ions from aqueous solutions. Here a simple and rapid flotation procedure is presented for the removal of copper(II) from aqueous solutions. It is based on the use of polyaluminum chloride silicate (PAX-XL60 S) as coagulant and flocculent, carbonate ion as activator and oleic acid (HOL) as surfactant. Both ion and precipitate flotation are included depending on the solution pH. Ion and precipitate flotation in the aqueous HOL-PAX-XL60 S-Cu2+-CO3(2-) system gave powerful preferential removal of Cu2+ (F -100%) over the HOL-PAX-XL60 S-Cu2+ system containing no CO3(2+) ion (F approximately 86%). The role of CO3(2-) ion is also evident from decreasing the dose of PAX-XL60 S from 700 mg l(-1) to 200 mg l(-1). The other parameters, influencing the flotation process, namely: metal ion, surfactant and PAX-XL60 S concentrations, ionic strength, temperature and foreign ions were examined. Moreover, the procedure was successfully applied to recover Cu2+ ions from different volumes up to 11 and from natural water samples.

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-16

In a clean-room environment at North Vandenberg Air Force Base, a technician begins the illumination testing of the AIM spacecraft at left. The AIM spacecraft will fly three instruments designed to study those clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-16

In a clean-room environment at North Vandenberg Air Force Base, a technician prepares the lights for illumination testing of the AIM spacecraft at left. The AIM spacecraft will fly three instruments designed to study those clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-16

In a clean-room environment at North Vandenberg Air Force Base, a technician monitors the AIM spacecraft after illumination testing on the spacecraft's solar array panels. The AIM spacecraft will fly three instruments designed to study those clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-16

In a clean-room environment at North Vandenberg Air Force Base, lights are reflected on the solar array panels of the AIM spacecraft during illumination testing. The AIM spacecraft will fly three instruments designed to study those clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-17

In a clean-room environment at North Vandenberg Air Force Base, technicians remove covers from instruments in the AIM spacecraft while solar panels are partially deployed. AIM will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-17

In a clean-room environment at North Vandenberg Air Force Base, technicians remove covers from instruments in the AIM spacecraft while solar panels are partially deployed. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Pegasus XL CYGNSS First Launch Attempt

NASA Image and Video Library

2016-12-12

Photographed from the F-18 pathfinder aircraft, the Orbital ATK L-1011 Stargazer aircraft is seen flying over the Atlantic Ocean offshore from Daytona Beach, Florida. Attached beneath the aircraft is the Pegasus XL rocket with eight Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. The CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes. The data that CYGNSS provides will enable scientists to probe key air-sea interaction processes that take place near the core of storms, which are rapidly changing and play a crucial role in the beginning and intensification of hurricanes. NOTE: The Dec. 12, 2016 launch attempt was postponed due to a hydraulic pump aboard the Orbital ATK L-1011 aircraft which is required to release the latches holding Pegasus in place, is not receiving power.

Improved Photometry for the DASCH Pipeline

NASA Astrophysics Data System (ADS)

Tang, Sumin; Grindlay, Jonathan; Los, Edward; Servillat, Mathieu

2013-07-01

The Digital Access to a Sky Century@Harvard (DASCH) project is digitizing the ˜500,000 glass plate images obtained (full sky) by the Harvard College Observatory from 1885 to 1992. Astrometry and photometry for each resolved object are derived with photometric rms values of ˜0.15 mag for the initial photometry analysis pipeline. Here we describe new developments for DASCH photometry, applied to the Kepler field, that have yielded further improvements, including better identification of image blends and plate defects by measuring image profiles and astrometric deviations. A local calibration procedure using nearby stars in a similar magnitude range as the program star (similar to what has been done for visual photometry from the plates) yields additional improvement for a net photometric rms of ˜0.1 mag. We also describe statistical measures of light curves that are now used in the DASCH pipeline processing to identify new variables autonomously. The DASCH photometry methods described here are used in the pipeline processing for the data releases of DASCH data,5 as well as for a forthcoming paper on the long-term variables discovered by DASCH in the Kepler field.

77 FR 63309 - Constitution Pipeline Company, LLC; Notice of Public Scoping Meeting and Extension of Scoping...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-16

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PF12-9-000] Constitution... Constitution Pipeline Project On October 24, 2012, the Federal Energy Regulatory Commission (FERC or Commission) will hold an additional public scoping meeting for Constitution Pipeline Company's (Constitution...

Quantification of hepatitis B surface antigen with the novel DiaSorin LIAISON XL Murex HBsAg Quant: correlation with the ARCHITECT quantitative assays.

PubMed

Burdino, Elisa; Ruggiero, Tina; Proietti, Alex; Milia, Maria Grazia; Olivero, Antonella; Caviglia, Gian Paolo; Marietti, Milena; Rizzetto, Mario; Smedile, Antonina; Ghisetti, Valeria

2014-08-01

Recent technologic innovations allow for quantitative assessment of hepatitis B surface antigen (HBsAg) levels in serum; this has been used to monitor the course of chronic HBV hepatitis (CHB) and predict treatment response. LIAISON-XL Murex HBsAg Quant assay (DiaSorin, Saluggia, I) is the newest immunoassay CE approved to quantify HBsAg. To compare LIAISON-XL performances with ARCHITECT-QT HBsAg (Abbott Diagnostics, IL, USA), as reference test. Sequential serum samples (n=152) from 14 HBe-negative patients with CHB, the majority of them infected by HBV genotype D undergoing antiviral treatment, were retrospectively tested with both assays. The 2nd WHO Standard 00/588 for HBsAg was used as reference. LIAISON-XL and ARCHITECT-QT correlated by r=0.95, p<0.0001; by Bland-Altman analysis agreement of mean difference was 0.21 ± 0.15 log 10 IU/mL, 95% CI: -0.07 to 0.5). Performance of LIAISON-XL against the 2nd WHO Standard was r=0.998, p<0.0001 (95% CI: 0.993-0.999) with results nearer to the expected WHO values compared to ARCHITECT-QT. Median baseline HBsAg level was similar with the two methods before antiviral treatment, throughout fluctuations of HBsAg level in treatment non-responders and during the decrease of HBsAg titer in treatment responders. Correlation between HBsAg levels and HBV DNA was statistically significant for both the two immunoassays (LIAISON-XL: r=0.4988, 95% CI: 0.3452-0.6264, p<0.0001; ARCHITECT-QT: r=0.480, 95% CI: 0.3233-0.6111, p<0.0001). Correlation between HBsAg measurement with LIAISON-XL and ARCHITECT-QT was high. LIAISON-XL accurately quantified HBsAg in clinical samples at baseline or during antiviral therapy; it can be applied for HBsAg quantification in clinical practice and decision making in CHB. Copyright © 2014 Elsevier B.V. All rights reserved.

Design Optimization of Innovative High-Level Waste Pipeline Unplugging Technologies - 13341

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pribanic, T.; Awwad, A.; Varona, J.

2013-07-01

Florida International University (FIU) is currently working on the development and optimization of two innovative pipeline unplugging methods: the asynchronous pulsing system (APS) and the peristaltic crawler system (PCS). Experiments were conducted on the APS to determine how air in the pipeline influences the system's performance as well as determine the effectiveness of air mitigation techniques in a pipeline. The results obtained during the experimental phase of the project, including data from pipeline pressure pulse tests along with air bubble compression tests are presented. Single-cycle pulse amplification caused by a fast-acting cylinder piston pump in 21.8, 30.5, and 43.6 mmore » pipelines were evaluated. Experiments were conducted on fully flooded pipelines as well as pipelines that contained various amounts of air to evaluate the system's performance when air is present in the pipeline. Also presented are details of the improvements implemented to the third generation crawler system (PCS). The improvements include the redesign of the rims of the unit to accommodate a camera system that provides visual feedback of the conditions inside the pipeline. Visual feedback allows the crawler to be used as a pipeline unplugging and inspection tool. Tests conducted previously demonstrated a significant reduction of the crawler speed with increasing length of tether. Current improvements include the positioning of a pneumatic valve manifold system that is located in close proximity to the crawler, rendering tether length independent of crawler speed. Additional improvements to increase the crawler's speed were also investigated and presented. Descriptions of the test beds, which were designed to emulate possible scenarios present on the Department of Energy (DOE) pipelines, are presented. Finally, conclusions and recommendations for the systems are provided. (authors)« less

Agreement among Goldmann applanation tonometer, iCare, and Icare PRO rebound tonometers; non-contact tonometer; and Tonopen XL in healthy elderly subjects.

PubMed

Kato, Yoshitake; Nakakura, Shunsuke; Matsuo, Naoko; Yoshitomi, Kayo; Handa, Marina; Tabuchi, Hitoshi; Kiuchi, Yoshiaki

2018-04-01

To evaluate the inter-device agreement among the Goldmann applanation tonometer (GAT), iCare and Icare PRO rebound tonometers, non-contact tonometer (NCT), and Tonopen XL tonometer. Sixty healthy elderly subjects were enrolled. The intraocular pressure (IOP) in each subject's right eye was measured thrice using each of the five tonometers. Intra-device agreement was evaluated by calculating intraclass correlation coefficients (ICCs). Inter-device agreement was evaluated by ICC and Bland-Altman analyses. ICCs for intra-device agreement for each tonometer were >0.8. IOP as measured by iCare (mean ± SD, 11.6 ± 2.5 mmHg) was significantly lower (p < 0.05) than that measured by GAT (14.0 ± 2.8 mmHg), NCT (13.6 ± 2.5 mmHg), Tonopen XL (13.7 ± 4.1 mmHg), and Icare PRO (12.6 ± 2.2 mmHg; Bonferroni test). There was no significant difference in mean IOP among GAT, NCT, and Tonopen XL. Regarding inter-device agreement, ICC was lower between Tonopen XL and other tonometers (all ICCs < 0.4). However, ICCs of GAT, iCare, Icare PRO, and NCT showed good agreement (0.576-0.700). The Bland-Altman analysis revealed that the width of the 95% limits of agreement was larger between the Tonopen XL and the other tonometers ranged from 14.94 to 16.47 mmHg. Among the other tonometers, however, the widths of 95% limits of agreement ranged from 7.91 to 9.24 mmHg. There was good inter-device agreement among GAT, rebound tonometers, and NCT. Tonopen XL shows the worst agreement with the other tonometers; therefore, we should pay attention to its' respective IOP. Japan Clinical Trials Register; number: UMIN000011544.

Open source pipeline for ESPaDOnS reduction and analysis

NASA Astrophysics Data System (ADS)

Martioli, Eder; Teeple, Doug; Manset, Nadine; Devost, Daniel; Withington, Kanoa; Venne, Andre; Tannock, Megan

2012-09-01

OPERA is a Canada-France-Hawaii Telescope (CFHT) open source collaborative software project currently under development for an ESPaDOnS echelle spectro-polarimetric image reduction pipeline. OPERA is designed to be fully automated, performing calibrations and reduction, producing one-dimensional intensity and polarimetric spectra. The calibrations are performed on two-dimensional images. Spectra are extracted using an optimal extraction algorithm. While primarily designed for CFHT ESPaDOnS data, the pipeline is being written to be extensible to other echelle spectrographs. A primary design goal is to make use of fast, modern object-oriented technologies. Processing is controlled by a harness, which manages a set of processing modules, that make use of a collection of native OPERA software libraries and standard external software libraries. The harness and modules are completely parametrized by site configuration and instrument parameters. The software is open- ended, permitting users of OPERA to extend the pipeline capabilities. All these features have been designed to provide a portable infrastructure that facilitates collaborative development, code re-usability and extensibility. OPERA is free software with support for both GNU/Linux and MacOSX platforms. The pipeline is hosted on SourceForge under the name "opera-pipeline".

75 FR 20653 - Notice of Availability of the Draft Environmental Impact Statement for the Proposed TransCanada...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-20

... Presidential permit for the construction, operation, and maintenance of pipeline facilities at the border of... referred to in Executive Order 13337, as amended, for the construction, connection, operation, or... environmental effects of the construction and operation of the United States portion of the Keystone XL Pipeline...

Pegasus XL CYGNSS Launch Attempt - Prepared for Takeoff - Scrubb

NASA Image and Video Library

2016-12-12

An Orbital ATK L-1011 Stargazer aircraft carrying a Pegasus XL Rocket with eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft is ready for takeoff from the Skid Strip at Cape Canaveral Air Force Station, Florida. With the aircraft flying off shore, the Pegasus rocket will be released. Five seconds later, the solid propellant engine will ignite and boost the eight hurricane observatories to orbit. The eight CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes.

Status of Natural Gas Pipeline System Capacity Entering the 2000-2001 Heating Season

EIA Publications

2000-01-01

This special report looks at the capabilities of the national natural gas pipeline network in 2000 and provides an assessment of the current levels of available capacity to transport supplies from production areas to markets throughout the United States during the upcoming heating season. It also examines how completion of currently planned expansion projects and proposed new pipelines would affect the network.

Development Of A Centrifugal Hydrogen Pipeline Gas Compressor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Di Bella, Francis A.

2015-04-16

Concepts NREC (CN) has completed a Department of Energy (DOE) sponsored project to analyze, design, and fabricate a pipeline capacity hydrogen compressor. The pipeline compressor is a critical component in the DOE strategy to provide sufficient quantities of hydrogen to support the expected shift in transportation fuels from liquid and natural gas to hydrogen. The hydrogen would be generated by renewable energy (solar, wind, and perhaps even tidal or ocean), and would be electrolyzed from water. The hydrogen would then be transported to the population centers in the U.S., where fuel-cell vehicles are expected to become popular and necessary tomore » relieve dependency on fossil fuels. The specifications for the required pipeline hydrogen compressor indicates a need for a small package that is efficient, less costly, and more reliable than what is available in the form of a multi-cylinder, reciprocating (positive displacement) compressor for compressing hydrogen in the gas industry.« less

78 FR 41991 - Pipeline Safety: Potential for Damage to Pipeline Facilities Caused by Flooding

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-12

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No...: Pipeline and Hazardous Materials Safety Administration (PHMSA); DOT. ACTION: Notice; Issuance of Advisory... Gas and Hazardous Liquid Pipeline Systems. Subject: Potential for Damage to Pipeline Facilities Caused...

78 FR 41496 - Pipeline Safety: Meetings of the Gas and Liquid Pipeline Advisory Committees

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-10

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2013-0156] Pipeline Safety: Meetings of the Gas and Liquid Pipeline Advisory Committees AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice of advisory committee...

Pipeline oil fire detection with MODIS active fire products

NASA Astrophysics Data System (ADS)

Ogungbuyi, M. G.; Martinez, P.; Eckardt, F. D.

2017-12-01

We investigate 85 129 MODIS satellite active fire events from 2007 to 2015 in the Niger Delta of Nigeria. The region is the oil base for Nigerian economy and the hub of oil exploration where oil facilities (i.e. flowlines, flow stations, trunklines, oil wells and oil fields) are domiciled, and from where crude oil and refined products are transported to different Nigerian locations through a network of pipeline systems. Pipeline and other oil facilities are consistently susceptible to oil leaks due to operational or maintenance error, and by acts of deliberate sabotage of the pipeline equipment which often result in explosions and fire outbreaks. We used ground oil spill reports obtained from the National Oil Spill Detection and Response Agency (NOSDRA) database (see www.oilspillmonitor.ng) to validate MODIS satellite data. NOSDRA database shows an estimate of 10 000 spill events from 2007 - 2015. The spill events were filtered to include largest spills by volume and events occurring only in the Niger Delta (i.e. 386 spills). By projecting both MODIS fire and spill as `input vector' layers with `Points' geometry, and the Nigerian pipeline networks as `from vector' layers with `LineString' geometry in a geographical information system, we extracted the nearest MODIS events (i.e. 2192) closed to the pipelines by 1000m distance in spatial vector analysis. The extraction process that defined the nearest distance to the pipelines is based on the global practices of the Right of Way (ROW) in pipeline management that earmarked 30m strip of land to the pipeline. The KML files of the extracted fires in a Google map validated their source origin to be from oil facilities. Land cover mapping confirmed fire anomalies. The aim of the study is to propose a near-real-time monitoring of spill events along pipeline routes using 250 m spatial resolution of MODIS active fire detection sensor when such spills are accompanied by fire events in the study location.

F-16XL ship #1 CAWAP flight - alpha 5 degrees, altitude 10,000 feet

NASA Technical Reports Server (NTRS)

1996-01-01

The single-seat F-16XL (ship #1) makes another run during the Cranked-Arrow Wing Aerodynamic Project (CAWAP) at Dryden Flight Research Center, Edwards, California. The modified airplane features a delta 'cranked-arrow' wing with strips of tubing along the leading edge to the trailing edge to sense static on the wing and obtain pressure distribution data. The right wing receives data on pressure distribution and the left wing has three types of instrumentation - preston tubes to measure local skin friction, boundary layer rakes to measure boundary layer profiles (the layer where the air interacts with the surfaces of a moving aircraft), and hot films to determine boundary layer transition locations. This photo shows the aircraft gathering data at an altitude of 10,000 feet, with an angle of attack of 5 degrees. The first flight of CAWAP occurred on November 21, 1995, and the test program ended in April 1996.

F-16XL ship #1 CAWAP flight - alpha 15 degrees, altitude 5,000 feet

NASA Technical Reports Server (NTRS)

1996-01-01

The single-seat F-16XL (ship #1) makes another run during the Cranked-Arrow Wing Aerodynamic Project (CAWAP) at Dryden Flight Research Center, Edwards, California. The modified airplane features a delta 'cranked-arrow' wing with strips of tubing along the leading edge to the trailing edge to sense static on the wing and obtain pressure distribution data. The right wing receives data on pressure distribution and the left wing has three types of instrumentation - preston tubes to measure local skin friction, boundary layer rakes to measure boundary layer profiles (the layer where the air interacts with the surfaces of a moving aircraft), and hot films to determine boundary layer transition locations. This photo shows the aircraft gathering data at an altitude of 5000 feet, with an angle of attack of 15 degrees. The program also gathered aero data on two wing planforms for NASA's High Speed Research Program. The first flight of CAWAP occurred on November 21, 1995, and the test program ended in April 1996.

Comparison of the clinical efficacy of twice-daily Ritalin and once-daily Equasym XL with placebo in children with Attention Deficit/Hyperactivity Disorder.

PubMed

Findling, Robert L; Quinn, Declan; Hatch, Simon J; Cameron, Sara J; DeCory, Heleen H; McDowell, Michael

2006-12-01

To compare the efficacy and safety of two methylphenidate (MPH) formulations--once-daily modified-release MPH (EqXL, Equasym XL) and twice-daily immediate-release methylphenidate (MPH-IR, Ritalin)--and placebo in children with Attention Deficit/Hyperactivity Disorder (ADHD). Children aged 6-12 years on a stable dose of MPH were randomized into a double-blind, three-arm, parallel-group, multi-center study and received 3 weeks of EqXL (20, 40, or 60 mg qd), MPH-IR (10, 20, or 30 mg bid) or placebo. Non-inferiority of EqXL to MPH-IR was assessed by the difference in the inattention/overactivity component of the overall teacher's IOWA Conners' Rating Scale on the last week of treatment (per protocol population). Safety was monitored by adverse events, laboratory parameters, vital signs, physical exam, and a Side Effect Rating Scale. The lower 97.5% confidence interval bound of the difference between MPH groups fell above the non-inferiority margin (-1.5 points) not only during the last week of treatment but during all three treatment weeks. Both MPH-treatment groups experienced superior benefit when compared to placebo during all treatment weeks (P < 0.001). All treatments were well tolerated. EqXL given once-daily was non-inferior to MPH-IR given twice-daily. Both treatments were superior to placebo in reducing ADHD symptoms.

The Application of PVDF in Converter Cooling Pipeline

NASA Astrophysics Data System (ADS)

Geng, Man; Lu, Zhimin

2017-11-01

The structure, mechanical property, thermodynamics property, electrical aspects, radiation property and chemical property were introduced, and PVDF could satisfy the requirement of converter cooling pipe. PVDF department and pipe of distribution pipeline of converter cooling system in Debao HVDC project are used to introduce the molding process of PVDF.

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-16

In Building 1555 at North Vandenberg Air Force Base, workers roll the AIM spacecraft into the "tent" where a partial deployment of the solar arrays on the spacecraft will take place. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-16

In Building 1555 at North Vandenberg Air Force Base, workers prepare the area where a partial deployment of the solar arrays on the AIM spacecraft will take place. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-16

In a clean-room environment containing the AIM spacecraft (background) at North Vandenberg Air Force Base, a technician studies results of illumination testing on the spacecraft's solar array panels. The AIM spacecraft will fly three instruments designed to study those clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-16

Inside the clean-room "tent" of Building 1555 at North Vandenberg Air Force Base, technicians in bunny suits prepare for the solar array deployment on the AIM spacecraft. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

A pharmacokinetic and pharmacodynamic comparison of immediate-release metoprolol and extended-release metoprolol CR/XL in patients with suspected acute myocardial infarction: a randomized, open-label study.

PubMed

Karlson, Björn W; Dellborg, Mikael; Gullestad, Lars; Aberg, Jan; Sugg, Jennifer; Herlitz, Johan

2014-01-01

Previous metoprolol studies in myocardial infarction patients were performed with immediate-release (IR) metoprolol. This study aims to evaluate if extended-release metoprolol CR/XL once daily gives a similar β-blockade over 24 h compared to multiple dosing of metoprolol IR. After 2 days of routine metoprolol treatment, 27 patients with suspected acute myocardial infarction were randomized to open-label treatment with metoprolol IR (50 mg four times daily or 100 mg twice daily) or metoprolol CR/XL 200 mg once daily for 3 days. Metoprolol CR/XL 200 mg once daily gave more pronounced suppression of peak heart rate, with lower peak and less variation in peak to trough plasma levels. There were no differences in AUC between the CR/XL and IR formulations, although the trough plasma metoprolol levels were comparable for metoprolol CR/XL 200 mg once daily and metoprolol IR 50 mg four times daily, but lower for metoprolol IR 100 mg twice daily. Both treatments were well tolerated. Metoprolol CR/XL 200 mg once daily showed lower peak and less variation in peak to trough plasma levels compared to multiple dosing of metoprolol IR with the same AUC. This was accompanied by a more uniform β-blockade over time, which was reflected by heart rate, and a more pronounced suppression of peak heart rate with similar tolerability. This suggests metoprolol CR/XL may be used as an alternative to metoprolol IR in patients with myocardial infarction. © 2013 S. Karger AG, Basel.

F-16XL ship #1 - CAWAP boundary layer rakes and hot film on left wing

NASA Technical Reports Server (NTRS)

1996-01-01

This photo shows the boundary layer hot film and the boundary layer rakes on the left wing of NASA's single-seat F-16XL (ship #1) used for the Cranked-Arrow Wing Aerodynamic Project (CAWAP) at Dryden Flight Research Center, Edwards, California. The modified airplane features a delta 'cranked-arrow' wing with strips of tubing along the leading edge to the trailing edge to sense static on the wing and obtain pressure distribution data. The right wing receives data on pressure distribution and the left wing has three types of instrumentation - preston tubes to measure local skin friction, boundary layer rakes to measure boundary layer profiles (the layer where the air interacts with the surfaces of a moving aircraft), and hot films to determine boundary layer transition locations. The first flight of CAWAP occurred on November 21, 1995, and the test program ended in April 1996.

76 FR 29333 - Pipeline Safety: Meetings of the Technical Pipeline Safety Standards Committee and the Technical...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-20

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No... Technical Hazardous Liquid Pipeline Safety Standards Committee AGENCY: Pipeline and Hazardous Materials... for natural gas pipelines and for hazardous liquid pipelines. Both committees were established under...

76 FR 43743 - Pipeline Safety: Meetings of the Technical Pipeline Safety Standards Committee and the Technical...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-21

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2011-0127] Pipeline Safety: Meetings of the Technical Pipeline Safety Standards Committee and the Technical Hazardous Liquid Pipeline Safety Standards Committee AGENCY: Pipeline and Hazardous Materials...

From Description to Explanation: An Empirical Exploration of the African-American Pipeline Problem in STEM

ERIC Educational Resources Information Center

Brown, Bryan A.; Henderson, J. Bryan; Gray, Salina; Donovan, Brian; Sullivan, Shayna; Patterson, Alexis; Waggstaff, William

2016-01-01

We conducted a mixed-methods study of matriculation issues for African-Americans in the STEM pipeline. The project compares the experiences of students currently majoring in science (N?=?304) with the experiences of those who have succeeded in earning science degrees (N?=?307). Participants were surveyed about their pipeline experiences based on…

77 FR 16471 - Pipeline Safety: Implementation of the National Registry of Pipeline and Liquefied Natural Gas...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-21

... Registry of Pipeline and Liquefied Natural Gas Operators AGENCY: Pipeline and Hazardous Materials Safety... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration 49 CFR Parts... Register (75 FR 72878) titled: ``Pipeline Safety: Updates to Pipeline and Liquefied Natural Gas Reporting...

Strengthening the STEM Education & Workforce Pipeline: Insights from the BHEF U.S. STEM Education Model Led to the STEM Higher Education and Workforce Project

DTIC Science & Technology

2011-06-15

ORGANIZATION NAME(S) AND ADDRESS(ES) Business-Higher Education Forum ,Washington,DC,20036 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING...Strengthening the STEM Education & Workforce Pipeline: Insights from the BHEF U.S. STEM Education Model Led to the STEM Higher Education and...Workforce Project Naval STEM Forum June 15, 2011 Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection of

a Smartphone-Based 3d Pipeline for the Creative Industry - the Replicate EU Project

NASA Astrophysics Data System (ADS)

Nocerino, E.; Lago, F.; Morabito, D.; Remondino, F.; Porzi, L.; Poiesi, F.; Rota Bulo, S.; Chippendale, P.; Locher, A.; Havlena, M.; Van Gool, L.; Eder, M.; Fötschl, A.; Hilsmann, A.; Kausch, L.; Eisert, P.

2017-02-01

During the last two decades we have witnessed great improvements in ICT hardware and software technologies. Three-dimensional content is starting to become commonplace now in many applications. Although for many years 3D technologies have been used in the generation of assets by researchers and experts, nowadays these tools are starting to become commercially available to every citizen. This is especially the case for smartphones, that are powerful enough and sufficiently widespread to perform a huge variety of activities (e.g. paying, calling, communication, photography, navigation, localization, etc.), including just very recently the possibility of running 3D reconstruction pipelines. The REPLICATE project is tackling this particular issue, and it has an ambitious vision to enable ubiquitous 3D creativity via the development of tools for mobile 3D-assets generation on smartphones/tablets. This article presents the REPLICATE project's concept and some of the ongoing activities, with particular attention being paid to advances made in the first year of work. Thus the article focuses on the system architecture definition, selection of optimal frames for 3D cloud reconstruction, automated generation of sparse and dense point clouds, mesh modelling techniques and post-processing actions. Experiments so far were concentrated on indoor objects and some simple heritage artefacts, however, in the long term we will be targeting a larger variety of scenarios and communities.

nanopipe: Calibration and data reduction pipeline for pulsar timing

NASA Astrophysics Data System (ADS)

Demorest, Paul B.

2018-03-01

nanopipe is a data reduction pipeline for calibration, RFI removal, and pulse time-of-arrival measurement from radio pulsar data. It was developed primarily for use by the NANOGrav project. nanopipe is written in Python, and depends on the PSRCHIVE (ascl:1105.014) library.

The Selective PI3K Inhibitor XL147 (SAR245408) Inhibits Tumor Growth and Survival and Potentiates the Activity of Chemotherapeutic Agents in Preclinical Tumor Models.

PubMed

Foster, Paul; Yamaguchi, Kyoko; Hsu, Pin P; Qian, Fawn; Du, Xiangnan; Wu, Jianming; Won, Kwang-Ai; Yu, Peiwen; Jaeger, Christopher T; Zhang, Wentao; Marlowe, Charles K; Keast, Paul; Abulafia, Wendy; Chen, Jason; Young, Jenny; Plonowski, Artur; Yakes, F Michael; Chu, Felix; Engell, Kelly; Bentzien, Frauke; Lam, Sanh T; Dale, Stephanie; Yturralde, Olivia; Matthews, David J; Lamb, Peter; Laird, A Douglas

2015-04-01

Dysregulation of PI3K/PTEN pathway components, resulting in hyperactivated PI3K signaling, is frequently observed in various cancers and correlates with tumor growth and survival. Resistance to a variety of anticancer therapies, including receptor tyrosine kinase (RTK) inhibitors and chemotherapeutic agents, has been attributed to the absence or attenuation of downregulating signals along the PI3K/PTEN pathway. Thus, PI3K inhibitors have therapeutic potential as single agents and in combination with other therapies for a variety of cancer indications. XL147 (SAR245408) is a potent and highly selective inhibitor of class I PI3Ks (α, β, γ, and δ). Moreover, broad kinase selectivity profiling of >130 protein kinases revealed that XL147 is highly selective for class I PI3Ks over other kinases. In cellular assays, XL147 inhibits the formation of PIP3 in the membrane, and inhibits phosphorylation of AKT, p70S6K, and S6 in multiple tumor cell lines with diverse genetic alterations affecting the PI3K pathway. In a panel of tumor cell lines, XL147 inhibits proliferation with a wide range of potencies, with evidence of an impact of genotype on sensitivity. In mouse xenograft models, oral administration of XL147 results in dose-dependent inhibition of phosphorylation of AKT, p70S6K, and S6 with a duration of action of at least 24 hours. Repeat-dose administration of XL147 results in significant tumor growth inhibition in multiple human xenograft models in nude mice. Administration of XL147 in combination with chemotherapeutic agents results in antitumor activity in xenograft models that is enhanced over that observed with the corresponding single agents. ©2015 American Association for Cancer Research.

Oman-India pipeline sets survey challenges. Crossing involves most rugged terrain, water depths four times greater than previous attempts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flynn, J.

1995-02-01

Decisions concerning the route for the world`s deepest pipeline call for some of the most challenging commercial oceanographic and engineering surveys ever undertaken. Oman Oil Co.`s 1, 170-kilometer pipeline will carry 2 billion cubic feet of gas daily across the Arabian Sea from Oman to the northern coast of India at the Gulf of Kutch. Not only will the project be in water depths four times greater than any previous pipeline, but it will cross some of the world`s most rugged seabed terrain, traversing ridges and plunging into deep canyons. Project costs are likely to approach $5 billion.

Whole Module Offgas Test Report: Space-Xl Dragon Module

NASA Technical Reports Server (NTRS)

James, John T.

2012-01-01

On September 26 and September 28,2012 a chemist from the JSC Toxicology Group acquired samples of air in 500 m1 evacuated canisters from the sealed Space-Xl Dragon Module. One sample was also acquired from Space-X Facility near the module at the start of the test. Samples of the module air were taken in triplicate once the module had been sealed, and then taken again in triplicate 1.98 days later. Ofthe triplicate samples, the first served as a line purge, and the last two were analyzed. The results of 5 samples are reported.

Pegasus XL CYGNSS Launch Attempt - Prepared for Takeoff - Scrubb

NASA Image and Video Library

2016-12-12

A pathfinder aircraft prepares for takeoff from the Skid Strip at Cape Canaveral Air Force Station in Florida. The airplane will provide photographic and video imagery of the Orbital ATK L-1011 Stargazer aircraft carrying a Pegasus XL Rocket with eight NASA Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft. With the aircraft flying off shore, the Pegasus rocket will be released. Five seconds later, the solid propellant engine will ignite and boost the eight hurricane observatories to orbit. The eight CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes.

Staubli TX-90XL robot qualification at the LLIHE.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Covert, Timothy Todd

The Light Initiated High Explosive (LIHE) Facility uses a robotic arm to spray explosive material onto test items for impulse tests. In 2007, the decision was made to replace the existing PUMA 760 robot with the Staubli TX-90XL. A qualification plan was developed and implemented to verify the safe operating conditions and failure modes of the new system. The robot satisfied the safety requirements established in the qualification plan. A performance issue described in this report remains unresolved at the time of this publication. The final readiness review concluded the qualification of this robot at the LIHE facility.

75 FR 45591 - Pipeline Safety: Notice of Technical Pipeline Safety Advisory Committee Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-03

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration 49 CFR Part... Committee Meetings AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA); DOT. ACTION... safety standards, risk assessments, and safety policies for natural gas pipelines and for hazardous...

Multinode reconfigurable pipeline computer

NASA Technical Reports Server (NTRS)

Nosenchuck, Daniel M. (Inventor); Littman, Michael G. (Inventor)

1989-01-01

A multinode parallel-processing computer is made up of a plurality of innerconnected, large capacity nodes each including a reconfigurable pipeline of functional units such as Integer Arithmetic Logic Processors, Floating Point Arithmetic Processors, Special Purpose Processors, etc. The reconfigurable pipeline of each node is connected to a multiplane memory by a Memory-ALU switch NETwork (MASNET). The reconfigurable pipeline includes three (3) basic substructures formed from functional units which have been found to be sufficient to perform the bulk of all calculations. The MASNET controls the flow of signals from the memory planes to the reconfigurable pipeline and vice versa. the nodes are connectable together by an internode data router (hyperspace router) so as to form a hypercube configuration. The capability of the nodes to conditionally configure the pipeline at each tick of the clock, without requiring a pipeline flush, permits many powerful algorithms to be implemented directly.

Russia joins Kazakh/Omani pipeline venture group

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-08-03

Russia has agreed to become a founding partner in a joint venture pipeline project formed by Kazakhstan and Oman. The agreement, signed in Bermuda July 24, is related to Chevron Corp.'s further development of supergiant Tengiz and Korolev fields along the Caspian Sea coast in Kazakhstan. Azerbaijan last month signed an agreement to become a founding member of the group, accepting terms agreed to by original joint venturers Kazakhstan and Oman. Azerbaijan's new government still must formally ratify its agreement. In addition, Chevron in June signed a memorandum of understanding to join the group at a future date. This papermore » reports that each of the founding members holds an equal interest in Caspian Pipeline Consortium Ltd., which will operate as a limited liability company incorporated in Bermuda.« less

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-16

Inside the clean-room "tent" of Building 1555 at North Vandenberg Air Force Base, a technician places a star tracker cover on the AIM spacecraft during testing of the solar array panel deployment. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to its launch vehicle, Orbital Sciences' Pegasus XL, during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-16

In Building 1555 at North Vandenberg Air Force Base, workers lift the AIM spacecraft from its stand in order to move it into an area where a partial deployment of the solar arrays on the spacecraft will take place. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-16

Inside the clean-room "tent" of Building 1555 at North Vandenberg Air Force Base, two of the solar array panels on the AIM spacecraft are deployed for testing. Inside are the instruments that will study polar mesospheric clouds located at the edge of space. The AIM spacecraft will fly three instruments designed to study those clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-10

Inside a clean room at Vandenberg Air Force Base in California, NASA's Aeronomy of Ice in the Mesosphere, or AIM, spacecraft is weighed. AIM is the seventh Small Explorers mission under NASA's Explorer Program. The program provides frequent flight opportunities for world-class scientific investigations from space within heliophysics and astrophysics. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-16

In Building 1555 at North Vandenberg Air Force Base, workers lower the AIM spacecraft onto a moveable base. AIM will be moved into an area where a partial deployment of the solar arrays on the spacecraft will take place.The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-16

In Building 1555 at North Vandenberg Air Force Base, workers get ready to attach the overhead crane to the AIM spacecraft. AIM will be moved into an area where a partial deployment of the solar arrays on the spacecraft will take place. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL AIM Arrival

NASA Image and Video Library

2007-03-10

NASA's Aeronomy of Ice in the Mesosphere, or AIM, spacecraft arrives in a clean room at Vandenberg Air Force Base in California. AIM is the seventh Small Explorers mission under NASA's Explorer Program. The program provides frequent flight opportunities for world-class scientific investigations from space within heliophysics and astrophysics. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to the Pegasus XL during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-16

Inside the clean-room "tent" of Building 1555 at North Vandenberg Air Force Base, technicians place a star tracker cover on the AIM spacecraft during testing of the solar array panel deployment. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to its launch vehicle, Orbital Sciences' Pegasus XL, during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

Orbital Sciences Pegasus XL AIM Processing

NASA Image and Video Library

2007-03-16

Inside the clean-room "tent" of Building 1555 at North Vandenberg Air Force Base, a star tracker cover is ready for placement on the AIM spacecraft during testing of the solar array panel deployment. The AIM spacecraft will fly three instruments designed to study polar mesospheric clouds located at the edge of space, 50 miles above the Earth's surface in the coldest part of the planet's atmosphere. The mission's primary goal is to explain why these clouds form and what has caused them to become brighter and more numerous and appear at lower latitudes in recent years. AIM's results will provide the basis for the study of long-term variability in the mesospheric climate and its relationship to global climate change. AIM is scheduled to be mated to its launch vehicle, Orbital Sciences' Pegasus XL, during the second week of April, after which final inspections will be conducted. Launch is scheduled for April 25.

F-16XL ship #1 - CAWAP boundary layer rakes and hot film on left wing

NASA Technical Reports Server (NTRS)

1996-01-01

This photo shows the boundary layer hot film and the boundary layer rakes on the left wing of NASA's single-seat F-16XL (ship #1) used for the Cranked-Arrow Wing Aerodynamic Project (CAWAP) at Dryden Flight Research Center, Edwards, California. The modified airplane features a delta 'cranked-arrow' wing with strips of tubing along the leading edge to the trailing edge to sense static on the wing and obtain pressure distribution data. The right wing receives data on pressure distribution and the left wing has three types of instrumentation - preston tubes to measure local skin friction, boundary layer rakes to measure boundary layer profiles (the layer where the air interacts with the surfaces of a moving aircraft), and hot films to determine boundary layer transition locations. The program also gathered aero data on two wing planforms for NASA's High Speed Research Program. The first flight of CAWAP occurred on November 21, 1995, and the test program ended in April 1996.

Pipeline repair development in support of the Oman to India gas pipeline

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abadie, W.; Carlson, W.

1995-12-01

This paper provides a summary of development which has been conducted to date for the ultra deep, diverless pipeline repair system for the proposed Oman to India Gas Pipeline. The work has addressed critical development areas involving testing and/or prototype development of tools and procedures required to perform a diverless pipeline repair in water depths of up to 3,525 m.

F-16XL-2 Supersonic Laminar Flow Control Flight Test Experiment

NASA Technical Reports Server (NTRS)

Anders, Scott G.; Fischer, Michael C.

1999-01-01

The F-16XL-2 Supersonic Laminar Flow Control Flight Test Experiment was part of the NASA High-Speed Research Program. The goal of the experiment was to demonstrate extensive laminar flow, to validate computational fluid dynamics (CFD) codes and design methodology, and to establish laminar flow control design criteria. Topics include the flight test hardware and design, airplane modification, the pressure and suction distributions achieved, the laminar flow achieved, and the data analysis and code correlation.

49 CFR 195.210 - Pipeline location.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 3 2010-10-01 2010-10-01 false Pipeline location. 195.210 Section 195.210 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.210 Pipeline location. (a) Pipeline right-of-way must be selected to avoid, as...

Development and characterization of K562 cell clones expressing BCL11A-XL: Decreased hemoglobin production with fetal hemoglobin inducers and its rescue with mithramycin

PubMed Central

Finotti, Alessia; Gasparello, Jessica; Breveglieri, Giulia; Cosenza, Lucia Carmela; Montagner, Giulia; Bresciani, Alberto; Altamura, Sergio; Bianchi, Nicoletta; Martini, Elisa; Gallerani, Eleonora; Borgatti, Monica; Gambari, Roberto

2015-01-01

Induction of fetal hemoglobin (HbF) is considered a promising strategy in the treatment of β-thalassemia, in which production of adult hemoglobin (HbA) is impaired by mutations affecting the β-globin gene. Recent results indicate that B-cell lymphoma/leukemia 11A (BCL11A) is a major repressor of γ-globin gene expression. Therefore, disrupting the binding of the BCL11A transcriptional repressor complex to the γ-globin gene promoter provides a novel approach for inducing expression of the γ-globin genes. To develop a cellular screening system for the identification of BCL11A inhibitors, we produced K562 cell clones with integrated copies of a BCL11A-XL expressing vector. We characterized 12 K562 clones expressing different levels of BCL11A-XL and found that a clear inverse relationship does exist between the levels of BCL11A-XL and the extent of hemoglobinization induced by a panel of HbF inducers. Using mithramycin as an inducer, we found that this molecule was the only HbF inducer efficient in rescuing the ability to differentiate along the erythroid program, even in K562 cell clones expressing high levels of BCL11A-XL, suggesting that BCL11A-XL activity is counteracted by mithramycin. PMID:26342260

77 FR 2126 - Pipeline Safety: Implementation of the National Registry of Pipeline and Liquefied Natural Gas...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-13

... Natural Gas Operators AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No...: ``Pipeline Safety: Updates to Pipeline and Liquefied Natural Gas Reporting Requirements.'' The final rule...

Comparison of carbon footprints of steel versus concrete pipelines for water transmission.

PubMed

Chilana, Lalit; Bhatt, Arpita H; Najafi, Mohammad; Sattler, Melanie

2016-05-01

The global demand for water transmission and service pipelines is expected to more than double between 2012 and 2022. This study compared the carbon footprint of the two most common materials used for large-diameter water transmission pipelines, steel pipe (SP) and prestressed concrete cylinder pipe (PCCP). A planned water transmission pipeline in Texas was used as a case study. Four life-cycle phases for each material were considered: material production and pipeline fabrication, pipe transportation to the job site, pipe installation in the trench, and operation of the pipeline. In each phase, the energy consumed and the CO2-equivalent emissions were quantified. It was found that pipe manufacturing consumed a large amount of energy, and thus contributed more than 90% of life cycle carbon emissions for both kinds of pipe. Steel pipe had 64% larger CO2-eq emissions from manufacturing compared to PCCP. For the transportation phase, PCCP consumed more fuel due to its heavy weight, and therefore had larger CO2-eq emissions. Fuel consumption by construction equipment for installation of pipe was found to be similar for steel pipe and PCCP. Overall, steel had a 32% larger footprint due to greater energy used during manufacturing. This study compared the carbon footprint of two large-diameter water transmission pipeline materials, steel and prestressed concrete cylinder, considering four life-cycle phases for each. The study provides information that project managers can incorporate into their decision-making process concerning pipeline materials. It also provides information concerning the most important phases of the pipeline life cycle to target for emission reductions.

Development and characterization of K562 cell clones expressing BCL11A-XL: Decreased hemoglobin production with fetal hemoglobin inducers and its rescue with mithramycin.

PubMed

Finotti, Alessia; Gasparello, Jessica; Breveglieri, Giulia; Cosenza, Lucia Carmela; Montagner, Giulia; Bresciani, Alberto; Altamura, Sergio; Bianchi, Nicoletta; Martini, Elisa; Gallerani, Eleonora; Borgatti, Monica; Gambari, Roberto

2015-12-01

Induction of fetal hemoglobin (HbF) is considered a promising strategy in the treatment of β-thalassemia, in which production of adult hemoglobin (HbA) is impaired by mutations affecting the β-globin gene. Recent results indicate that B-cell lymphoma/leukemia 11A (BCL11A) is a major repressor of γ-globin gene expression. Therefore, disrupting the binding of the BCL11A transcriptional repressor complex to the γ-globin gene promoter provides a novel approach for inducing expression of the γ-globin genes. To develop a cellular screening system for the identification of BCL11A inhibitors, we produced K562 cell clones with integrated copies of a BCL11A-XL expressing vector. We characterized 12 K562 clones expressing different levels of BCL11A-XL and found that a clear inverse relationship does exist between the levels of BCL11A-XL and the extent of hemoglobinization induced by a panel of HbF inducers. Using mithramycin as an inducer, we found that this molecule was the only HbF inducer efficient in rescuing the ability to differentiate along the erythroid program, even in K562 cell clones expressing high levels of BCL11A-XL, suggesting that BCL11A-XL activity is counteracted by mithramycin. Copyright © 2015 ISEH - International Society for Experimental Hematology. Published by Elsevier Inc. All rights reserved.

75 FR 72877 - Pipeline Safety: Updates to Pipeline and Liquefied Natural Gas Reporting Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-26

... liquid pipelines, and liquefied natural gas (LNG) facilities. These revisions will enhance PHMSA's... of natural gas pipelines, hazardous liquid pipelines, and LNG facilities. Specifically, PHMSA... commodity transported, and type of commodity transported. 8. Modify hazardous liquid operator telephonic...

78 FR 42889 - Pipeline Safety: Reminder of Requirements for Utility LP-Gas and LPG Pipeline Systems

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-18

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration 49 CFR Part 192 [Docket No. PHMSA-2013-0097] Pipeline Safety: Reminder of Requirements for Utility LP-Gas and LPG Pipeline Systems AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION...

A Pipeline Tool for CCD Image Processing

NASA Astrophysics Data System (ADS)

Bell, Jon F.; Young, Peter J.; Roberts, William H.; Sebo, Kim M.

MSSSO is part of a collaboration developing a wide field imaging CCD mosaic (WFI). As part of this project, we have developed a GUI based pipeline tool that is an integrated part of MSSSO's CICADA data acquisition environment and processes CCD FITS images as they are acquired. The tool is also designed to run as a stand alone program to process previously acquired data. IRAF tasks are used as the central engine, including the new NOAO mscred package for processing multi-extension FITS files. The STScI OPUS pipeline environment may be used to manage data and process scheduling. The Motif GUI was developed using SUN Visual Workshop. C++ classes were written to facilitate launching of IRAF and OPUS tasks. While this first version implements calibration processing up to and including flat field corrections, there is scope to extend it to other processing.

Method and system for pipeline communication

DOEpatents

Richardson,; John, G [Idaho Falls, ID

2008-01-29

A pipeline communication system and method includes a pipeline having a surface extending along at least a portion of the length of the pipeline. A conductive bus is formed to and extends along a portion of the surface of the pipeline. The conductive bus includes a first conductive trace and a second conductive trace with the first and second conductive traces being adapted to conformally couple with a pipeline at the surface extending along at least a portion of the length of the pipeline. A transmitter for sending information along the conductive bus on the pipeline is coupled thereto and a receiver for receiving the information from the conductive bus on the pipeline is also couple to the conductive bus.

77 FR 38614 - Northwest Pipeline, GP; Notice of Intent To Prepare an Environmental Assessment for the Proposed...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-28

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PF12-2-000] Northwest Pipeline, GP; Notice of Intent To Prepare an Environmental Assessment for the Proposed Kalama Lateral Pipeline Project, Request for Comments on Environmental Issues, and Notice of Public Scoping Meeting The staff of the Federal Energy Regulatory Commissio...

77 FR 34034 - Corpus Christi Liquefaction, LLC; Cheniere Corpus Christi Pipeline, L.P.; Notice of Intent To...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-08

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PF12-3-000] Corpus Christi Liquefaction, LLC; Cheniere Corpus Christi Pipeline, L.P.; Notice of Intent To Prepare an Environmental Assessment for the Planned Corpus Christi LNG Terminal and Pipeline Project, Request for Comments on Environmental Issues, and Notice of Public...

F-16XL ship #1 CAWAP flight - alpha 21 degrees, altitude 17,500 feet

NASA Technical Reports Server (NTRS)

1996-01-01

The single-seat F-16XL (ship #1) makes another run during the Cranked-Arrow Wing Aerodynamic Project (CAWAP) at Dryden Flight Research Center, Edwards, California. The modified airplane features a delta 'cranked-arrow' wing with strips of tubing along the leading edge to the trailing edge to sense static on the wing and obtain pressure distribution data. The right wing receives data on pressure distribution and the left wing (visible here) has three types of instrumentation - preston tubes to measure local skin friction, boundary layer rakes to measure boundary layer profiles (the layer where the air interacts with the surfaces of a moving aircraft), and hot films to determine boundary layer transition locations. This photo shows the aircraft gathering data at an altitude of 17,500 feet, with an angle of attack of 21 degrees The program also gathered aero data on two wing planforms for NASA's High Speed Research Program. The first flight of CAWAP occurred on November 21, 1995, and the test program ended in April 1996.

Lessons Learned from Numerical Simulations of the F-16XL Aircraft at Flight Conditions

NASA Technical Reports Server (NTRS)

Rizzi, Arthur; Jirasek, Adam; Lamar, John; Crippa, Simone; Badcock, Kenneth; Boelens, Oklo

2009-01-01

Nine groups participating in the Cranked Arrow Wing Aerodynamics Project International (CAWAPI) project have contributed steady and unsteady viscous simulations of a full-scale, semi-span model of the F-16XL aircraft. Three different categories of flight Reynolds/Mach number combinations were computed and compared with flight-test measurements for the purpose of code validation and improved understanding of the flight physics. Steady-state simulations are done with several turbulence models of different complexity with no topology information required and which overcome Boussinesq-assumption problems in vortical flows. Detached-eddy simulation (DES) and its successor delayed detached-eddy simulation (DDES) have been used to compute the time accurate flow development. Common structured and unstructured grids as well as individually-adapted unstructured grids were used. Although discrepancies are observed in the comparisons, overall reasonable agreement is demonstrated for surface pressure distribution, local skin friction and boundary velocity profiles at subsonic speeds. The physical modeling, steady or unsteady, and the grid resolution both contribute to the discrepancies observed in the comparisons with flight data, but at this time it cannot be determined how much each part contributes to the whole. Overall it can be said that the technology readiness of CFD-simulation technology for the study of vehicle performance has matured since 2001 such that it can be used today with a reasonable level of confidence for complex configurations.

What Was Learned in Predicting Slender Airframe Aerodynamics with the F-16XL Aircraft

NASA Technical Reports Server (NTRS)

Rizzi, Arthur; Luckring, James M.

2016-01-01

The second Cranked-Arrow Wing Aerodynamics Project, International, coordinated project has been underway to improve high-fidelity computational-fluid-dynamics predictions of slender airframe aerodynamics. The work is focused on two flow conditions and leverages a unique flight data set obtained with the F-16XL aircraft for comparison and validation. These conditions, a low-speed high-angle-of-attack case and a transonic low-angle-of-attack case, were selected from a prior prediction campaign wherein the computational fluid dynamics failed to provide acceptable results. In revisiting these two cases, approaches for improved results include better, denser grids using more grid adaptation to local flow features as well as unsteady higher-fidelity physical modeling like hybrid Reynolds-averaged Navier-Stokes/unsteady Reynolds-averaged Navier-Stokes/large-eddy simulation methods. The work embodies predictions from multiple numerical formulations that are contributed from multiple organizations where some authors investigate other possible factors that could explain the discrepancies in agreement (e.g., effects due to deflected control surfaces during the flight tests as well as static aeroelastic deflection of the outer wing). This paper presents the synthesis of all the results and findings and draws some conclusions that lead to an improved understanding of the underlying flow physics, finally making the connections between the physics and aircraft features.

76 FR 75894 - Information Collection Activities: Pipelines and Pipeline Rights-of-Way; Submitted for Office of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-05

... pipelines `` * * * for the transportation of oil, natural gas, sulphur, or other minerals, or under such...) Submit repair report 3 1008(f) Submit report of pipeline failure analysis...... 30 1008(g) Submit plan of.... BSEE-2011-0002; OMB Control Number 1010-0050] Information Collection Activities: Pipelines and Pipeline...

77 FR 16052 - Information Collection Activities: Pipelines and Pipeline Rights-of-Way; Submitted for Office of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-19

... submerged lands of the OCS for pipelines ``* * * for the transportation of oil, natural gas, sulphur, or... ensure that the pipeline, as constructed, will provide for safe transportation of oil and gas and other...-0002; OMB Control Number 1014-0016] Information Collection Activities: Pipelines and Pipeline Rights...

Clinical significance of proliferation, apoptosis and senescence of nasopharyngeal cells by the simultaneously blocking EGF, IGF-1 receptors and Bcl-xl genes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dai, Guodong; Peng, Tao; Zhou, Xuhong

2013-11-01

Highlight: •Construction of shRNA segments expression vectors is valid by the investigation of RT-PCR for IGF1R, EGFR and Bcl-xl mRNA and protein expression. •Studies have suggested that the vectors in blocking these genes of the growth factor receptors and anti- apoptosis is capable of breaking the balance of tumor growth so that tumor trend apoptosis and senescence. •Simultaneously blocking multiple genes that are abnormally expressed may be more effective in treating cancer cells than silencing a single gene. -- Abstract: Background: In previous work, we constructed short hairpin RNA (shRNA) expression plasmids that targeted human EGF and IGF-1 receptors messengermore » RNA, respectively, and demonstrated that these vectors could induce apoptosis of human nasopharyngeal cell lines (CNE2) and inhibit ligand-induced pAkt and pErk activation. Method: We have constructed multiple shRNA expression vectors of targeting EGFR, IGF1R and Bcl-xl, which were transfected to the CNE2 cells. The mRNA expression was assessed by RT-PCR. The growth of the cells, cell cycle progression, apoptosis of the cells, senescent tumor cells and the proteins of EGFR, IGF1R and Bcl-xl were analyzed by MTT, flow cytometry, cytochemical therapy or Western blot. Results: In group of simultaneously blocking EGFR, IGF1R and Bcl-xl genes, the mRNA of EGFR, IGF1R and Bcl-xl expression was decreased by (66.66 ± 3.42)%, (73.97 ± 2.83)% and (64.79 ± 2.83)%, and the protein expressions was diminished to (67.69 ± 4.02)%, (74.32 ± 2.30)%, and (60.00 ± 3.34)%, respectively. Meanwhile, the cell apoptosis increased by 65.32 ± 0.18%, 65.16 ± 0.25% and 55.47 ± 0.45%, and senescent cells increased by 1.42 ± 0.15%, 2.26 ± 0.15% and 3.22 ± 0.15% in the second, third and fourth day cultures, respectively. Conclusions: Simultaneously blocking EGFR, IGF1R and Bcl-xl genes is capable of altering the balance between proliferating versus apoptotic and senescent cells in the favor of both of

Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic.

PubMed

Fuchs, Helmut; Aguilar-Pimentel, Juan Antonio; Amarie, Oana V; Becker, Lore; Calzada-Wack, Julia; Cho, Yi-Li; Garrett, Lillian; Hölter, Sabine M; Irmler, Martin; Kistler, Martin; Kraiger, Markus; Mayer-Kuckuk, Philipp; Moreth, Kristin; Rathkolb, Birgit; Rozman, Jan; da Silva Buttkus, Patricia; Treise, Irina; Zimprich, Annemarie; Gampe, Kristine; Hutterer, Christine; Stöger, Claudia; Leuchtenberger, Stefanie; Maier, Holger; Miller, Manuel; Scheideler, Angelika; Wu, Moya; Beckers, Johannes; Bekeredjian, Raffi; Brielmeier, Markus; Busch, Dirk H; Klingenspor, Martin; Klopstock, Thomas; Ollert, Markus; Schmidt-Weber, Carsten; Stöger, Tobias; Wolf, Eckhard; Wurst, Wolfgang; Yildirim, Ali Önder; Zimmer, Andreas; Gailus-Durner, Valérie; Hrabě de Angelis, Martin

2017-09-29

Since decades, model organisms have provided an important approach for understanding the mechanistic basis of human diseases. The German Mouse Clinic (GMC) was the first phenotyping facility that established a collaboration-based platform for phenotype characterization of mouse lines. In order to address individual projects by a tailor-made phenotyping strategy, the GMC advanced in developing a series of pipelines with tests for the analysis of specific disease areas. For a general broad analysis, there is a screening pipeline that covers the key parameters for the most relevant disease areas. For hypothesis-driven phenotypic analyses, there are thirteen additional pipelines with focus on neurological and behavioral disorders, metabolic dysfunction, respiratory system malfunctions, immune-system disorders and imaging techniques. In this article, we give an overview of the pipelines and describe the scientific rationale behind the different test combinations. Copyright © 2017 Elsevier B.V. All rights reserved.

Hydrocarbons pipeline transportation risk assessment

NASA Astrophysics Data System (ADS)

Zanin, A. V.; Milke, A. A.; Kvasov, I. N.

2018-04-01

The pipeline transportation applying risks assessment issue in the arctic conditions is addressed in the paper. Pipeline quality characteristics in the given environment has been assessed. To achieve the stated objective, the pipelines mathematical model was designed and visualized by using the software product SOLIDWORKS. When developing the mathematical model the obtained results made possible to define the pipeline optimal characteristics for designing on the Arctic sea bottom. In the course of conducting the research the pipe avalanche collapse risks were examined, internal longitudinal and circular loads acting on the pipeline were analyzed, as well as the water impact hydrodynamic force was taken into consideration. The conducted calculation can contribute to the pipeline transport further development under the harsh climate conditions of the Russian Federation Arctic shelf territory.

Spectral Accuracy and Sulfur Counting Capabilities of the LTQ-FT-ICR and the LTQ-Orbitrap XL for Small Molecule Analysis

NASA Astrophysics Data System (ADS)

Blake, Samantha L.; Walker, S. Hunter; Muddiman, David C.; Hinks, David; Beck, Keith R.

2011-12-01

Color Index Disperse Yellow 42 (DY42), a high-volume disperse dye for polyester, was used to compare the capabilities of the LTQ-Orbitrap XL and the LTQ-FT-ICR with respect to mass measurement accuracy (MMA), spectral accuracy, and sulfur counting. The results of this research will be used in the construction of a dye database for forensic purposes; the additional spectral information will increase the confidence in the identification of unknown dyes found in fibers at crime scenes. Initial LTQ-Orbitrap XL data showed MMAs greater than 3 ppm and poor spectral accuracy. Modification of several Orbitrap installation parameters (e.g., deflector voltage) resulted in a significant improvement of the data. The LTQ-FT-ICR and LTQ-Orbitrap XL (after installation parameters were modified) exhibited MMA ≤ 3 ppm, good spectral accuracy (χ2 values for the isotopic distribution ≤ 2), and were correctly able to ascertain the number of sulfur atoms in the compound at all resolving powers investigated for AGC targets of 5.00 × 105 and 1.00 × 106.

Pipeline surveillance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1976-03-01

Each week, pilots of Michigan Wisconsin Pipe Line Co.'s aerial patrol fly over the entire 12,000 mi of the company's pipeline system to discover possible gas leaks and prevent accidental encroachment of pipeline right-of-way. (Leaks are uncommon, but as many as 10 potential trespassing incidents can occur along a route in a week.) Following the pipeline is facilitated by the warmth emitted by the line which affects the plant life directly above it. Gas leaks may be indicated by a patch of brown vegetation or by sediment brought to water surfaces by escaping gas bubbles. The 1- and 2-engine patrolmore » planes, which receive special permission from federal authorities to fly at low altitudes, undergo 100-h safety checks and frequent overhauls.« less

Commanding Constellations (Pipeline Architecture)

NASA Technical Reports Server (NTRS)

Ray, Tim; Condron, Jeff

2003-01-01

Providing ground command software for constellations of spacecraft is a challenging problem. Reliable command delivery requires a feedback loop; for a constellation there will likely be an independent feedback loop for each constellation member. Each command must be sent via the proper Ground Station, which may change from one contact to the next (and may be different for different members). Dynamic configuration of the ground command software is usually required (e.g. directives to configure each member's feedback loop and assign the appropriate Ground Station). For testing purposes, there must be a way to insert command data at any level in the protocol stack. The Pipeline architecture described in this paper can support all these capabilities with a sequence of software modules (the pipeline), and a single self-identifying message format (for all types of command data and configuration directives). The Pipeline architecture is quite simple, yet it can solve some complex problems. The resulting solutions are conceptually simple, and therefore, reliable. They are also modular, and therefore, easy to distribute and extend. We first used the Pipeline architecture to design a CCSDS (Consultative Committee for Space Data Systems) Ground Telecommand system (to command one spacecraft at a time with a fixed Ground Station interface). This pipeline was later extended to include gateways to any of several Ground Stations. The resulting pipeline was then extended to handle a small constellation of spacecraft. The use of the Pipeline architecture allowed us to easily handle the increasing complexity. This paper will describe the Pipeline architecture, show how it was used to solve each of the above commanding situations, and how it can easily be extended to handle larger constellations.

State Policies Affecting the "Adult Re-Entry Pipeline" in Postsecondary Education: Results of a Fifty-State Inventory

ERIC Educational Resources Information Center

Boeke, Marianne; Zis, Stacey; Ewell, Peter

2011-01-01

With support from the Bill and Melinda Gates Foundation, the National Center for Higher Education Management Systems (NCHEMS) is engaged in a two year project centered on state policies that foster student progression and success in the "adult re-entry pipeline." The adult re-entry pipeline consists of the many alternative pathways to…

The effect of bupropion XL and escitalopram on memory and functional outcomes in adults with major depressive disorder: results from a randomized controlled trial.

PubMed

Soczynska, Joanna K; Ravindran, Lakshmi N; Styra, Rima; McIntyre, Roger S; Cyriac, Anna; Manierka, Marena S; Kennedy, Sidney H

2014-12-15

Decrements in cognitive function are a common feature of Major Depressive Disorder (MDD), and whether distinct classes of antidepressants differentially affect memory in these individuals has not been sufficiently evaluated. In this study we sought to determine the effect of escitalopram and bupropion XL on memory and psychosocial function. Forty-one individuals (18-50 years) with MDD were enrolled in an 8-week, double-blind, double-dummy, randomized controlled comparative trial of bupropion XL and escitalopram. Thirty-six participants completed pre and post memory assessments. Verbal, non-verbal and working memory were evaluated with a comprehensive neuropsychological battery. Psychosocial function was assessed with the Sheehan Disability Scale and Endicott Work Productivity Scale. Escitalopram and bupropion XL significantly improved immediate as well as delayed verbal and nonverbal memory, global function (all p≤0.001), and work productivity (p=0.045), with no significant between-group differences. Improvement in immediate verbal memory exerted a direct influence on improvement in global function (p=0.006). Treatment with either escitalopram or bupropion XL was associated with improvement in memory and psychosocial function in adults with MDD. Copyright © 2014. Published by Elsevier Ireland Ltd.

Managing risks in the project pipeline.

DOT National Transportation Integrated Search

2013-08-01

This research focuses on how to manage the risks of project costs and revenue uncertainties over the long-term, and identifies significant : process improvements to ensure projects are delivered on time and as intended, thus maximizing the miles pave...

Active matrix organic light emitting diode (AMOLED)-XL performance and life test results

NASA Astrophysics Data System (ADS)

Fellowes, David A.; Wood, Michael V.; Hastings, Arthur R., Jr.; Draper, Russell S.; Lum, Alden K.; Ghosh, Amalkumar P.; Prache, Olivier; Wacyk, Ihor

2009-05-01

The US Army and eMagin Corporation established a Cooperative Research and Development Agreement (CRADA) to characterize the ongoing improvements in the lifetime of OLED displays. This CRADA also called for the evaluation of OLED performance as the need arises, especially when new products are developed or when a previously untested parameter needs to be understood. In 2006, eMagin Corporation developed long-life OLED-XL devices for use in their AMOLED microdisplays for head-worn applications. RDECOM CERDEC NVESD conducted life tests on these displays, finding over 200% lifetime improvement for the OLED-XL devices over the standard OLED displays, publishing results at the 2007 and 2008 SPIE Defense and Security Symposia1,2. In 2008, eMagin Corporation made additional improvements on the lifetime of their displays and developed the first SXGA (1280 × 1024 triad pixels) OLED microdisplay. A summary of the life and performance tests run at CERDEC NVESD will be presented along with a recap of previous data. This should result in a better understanding of the applicability of AMOLEDs in military and commercial head mounted systems: where good fits are made, and where further development might be desirable.

77 FR 9944 - Determination That REQUIP XL (Ropinerole Hydrochloride) Extended-Release Tablets, 3 Milligrams...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-21

... Parkinson's disease. REQUIP XL (ropinerole hydrochloride) extended-release tablets, 3 mg, are currently... amendments include what is now section 505(j)(7) of the Federal Food, Drug, and Cosmetic Act (21 U.S.C. 355(j... suspends approval of the drug's NDA or ANDA for reasons of safety or effectiveness or if FDA determines...

Main Pipelines Corrosion Monitoring Device

NASA Astrophysics Data System (ADS)

Anatoliy, Bazhenov; Galina, Bondareva; Natalia, Grivennaya; Sergey, Malygin; Mikhail, Goryainov

2017-01-01

The aim of the article is to substantiate the technical solution for the problem of monitoring corrosion changes in oil and gas pipelines with use (using) of an electromagnetic NDT method. Pipeline wall thinning under operating conditions can lead to perforations and leakage of the product to be transported outside the pipeline. In most cases there is danger for human life and environment. Monitoring of corrosion changes in pipeline inner wall under operating conditions is complicated because pipelines are mainly made of structural steels with conductive and magnetic properties that complicate test signal passage through the entire thickness of the object under study. The technical solution of this problem lies in monitoring of the internal corrosion changes in pipes under operating conditions in order to increase safety of pipelines by automated prediction of achieving the threshold pre-crash values due to corrosion.

Image processing pipeline for synchrotron-radiation-based tomographic microscopy.

PubMed

Hintermüller, C; Marone, F; Isenegger, A; Stampanoni, M

2010-07-01

With synchrotron-radiation-based tomographic microscopy, three-dimensional structures down to the micrometer level can be visualized. Tomographic data sets typically consist of 1000 to 1500 projections of 1024 x 1024 to 2048 x 2048 pixels and are acquired in 5-15 min. A processing pipeline has been developed to handle this large amount of data efficiently and to reconstruct the tomographic volume within a few minutes after the end of a scan. Just a few seconds after the raw data have been acquired, a selection of reconstructed slices is accessible through a web interface for preview and to fine tune the reconstruction parameters. The same interface allows initiation and control of the reconstruction process on the computer cluster. By integrating all programs and tools, required for tomographic reconstruction into the pipeline, the necessary user interaction is reduced to a minimum. The modularity of the pipeline allows functionality for new scan protocols to be added, such as an extended field of view, or new physical signals such as phase-contrast or dark-field imaging etc.

About U.S. Natural Gas Pipelines

EIA Publications

2007-01-01

This information product provides the interested reader with a broad and non-technical overview of how the U.S. natural gas pipeline network operates, along with some insights into the many individual pipeline systems that make up the network. While the focus of the presentation is the transportation of natural gas over the interstate and intrastate pipeline systems, information on subjects related to pipeline development, such as system design and pipeline expansion, are also included.

KAnalyze: a fast versatile pipelined k-mer toolkit.

PubMed

Audano, Peter; Vannberg, Fredrik

2014-07-15

Converting nucleotide sequences into short overlapping fragments of uniform length, k-mers, is a common step in many bioinformatics applications. While existing software packages count k-mers, few are optimized for speed, offer an application programming interface (API), a graphical interface or contain features that make it extensible and maintainable. We designed KAnalyze to compete with the fastest k-mer counters, to produce reliable output and to support future development efforts through well-architected, documented and testable code. Currently, KAnalyze can output k-mer counts in a sorted tab-delimited file or stream k-mers as they are read. KAnalyze can process large datasets with 2 GB of memory. This project is implemented in Java 7, and the command line interface (CLI) is designed to integrate into pipelines written in any language. As a k-mer counter, KAnalyze outperforms Jellyfish, DSK and a pipeline built on Perl and Linux utilities. Through extensive unit and system testing, we have verified that KAnalyze produces the correct k-mer counts over multiple datasets and k-mer sizes. KAnalyze is available on SourceForge: https://sourceforge.net/projects/kanalyze/. © The Author 2014. Published by Oxford University Press.

A Microsoft-Excel-based tool for running and critically appraising network meta-analyses--an overview and application of NetMetaXL.

PubMed

Brown, Stephen; Hutton, Brian; Clifford, Tammy; Coyle, Doug; Grima, Daniel; Wells, George; Cameron, Chris

2014-09-29

The use of network meta-analysis has increased dramatically in recent years. WinBUGS, a freely available Bayesian software package, has been the most widely used software package to conduct network meta-analyses. However, the learning curve for WinBUGS can be daunting, especially for new users. Furthermore, critical appraisal of network meta-analyses conducted in WinBUGS can be challenging given its limited data manipulation capabilities and the fact that generation of graphical output from network meta-analyses often relies on different software packages than the analyses themselves. We developed a freely available Microsoft-Excel-based tool called NetMetaXL, programmed in Visual Basic for Applications, which provides an interface for conducting a Bayesian network meta-analysis using WinBUGS from within Microsoft Excel. . This tool allows the user to easily prepare and enter data, set model assumptions, and run the network meta-analysis, with results being automatically displayed in an Excel spreadsheet. It also contains macros that use NetMetaXL's interface to generate evidence network diagrams, forest plots, league tables of pairwise comparisons, probability plots (rankograms), and inconsistency plots within Microsoft Excel. All figures generated are publication quality, thereby increasing the efficiency of knowledge transfer and manuscript preparation. We demonstrate the application of NetMetaXL using data from a network meta-analysis published previously which compares combined resynchronization and implantable defibrillator therapy in left ventricular dysfunction. We replicate results from the previous publication while demonstrating result summaries generated by the software. Use of the freely available NetMetaXL successfully demonstrated its ability to make running network meta-analyses more accessible to novice WinBUGS users by allowing analyses to be conducted entirely within Microsoft Excel. NetMetaXL also allows for more efficient and transparent

Alaska oil pipeline in retrospect

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klein, D.R.

Caribou have not adjusted as well as moose to the presence of the trans-Alaska pipeline. Research has shown that caribou have altered their movements and patterns and range use in relation to the pipeline corridor. Cows with calves show pronounced avoidance of the pipeline, road, and oil field. Traffic and human activity appear more directly responsible for avoidance behavior than does that physical presence of the pipeline, road, and facilities. Animals along the haul road are especially vulnerable to poaching because of the open terrain and the fact that many become tame during the peak of construction activity. Poaching, especiallymore » of furbearers, has increased as pipeline-related traffic has decreased.« less

The ALMA Science Pipeline: Current Status

NASA Astrophysics Data System (ADS)

Humphreys, Elizabeth; Miura, Rie; Brogan, Crystal L.; Hibbard, John; Hunter, Todd R.; Indebetouw, Remy

2016-09-01

The ALMA Science Pipeline is being developed for the automated calibration and imaging of ALMA interferometric and single-dish data. The calibration Pipeline for interferometric data was accepted for use by ALMA Science Operations in 2014, and for single-dish data end-to-end processing in 2015. However, work is ongoing to expand the use cases for which the Pipeline can be used e.g. for higher frequency and lower signal-to-noise datasets, and for new observing modes. A current focus includes the commissioning of science target imaging for interferometric data. For the Single Dish Pipeline, the line finding algorithm used in baseline subtraction and baseline flagging heuristics have been greately improved since the prototype used for data from the previous cycle. These algorithms, unique to the Pipeline, produce better results than standard manual processing in many cases. In this poster, we report on the current status of the Pipeline capabilities, present initial results from the Imaging Pipeline, and the smart line finding and flagging algorithm used in the Single Dish Pipeline. The Pipeline is released as part of CASA (the Common Astronomy Software Applications package).

75 FR 4134 - Pipeline Safety: Leak Detection on Hazardous Liquid Pipelines

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-26

... http://dms.dot.gov . General information about the PHMSA Office of Pipeline Safety (OPS) can be... of leak detection by tracking product movement is essential to an understanding of line balance... pipelines, the line balance technique for leak detection can often be performed with manual calculations...

Integration of a neuroimaging processing pipeline into a pan-canadian computing grid

NASA Astrophysics Data System (ADS)

Lavoie-Courchesne, S.; Rioux, P.; Chouinard-Decorte, F.; Sherif, T.; Rousseau, M.-E.; Das, S.; Adalat, R.; Doyon, J.; Craddock, C.; Margulies, D.; Chu, C.; Lyttelton, O.; Evans, A. C.; Bellec, P.

2012-02-01

The ethos of the neuroimaging field is quickly moving towards the open sharing of resources, including both imaging databases and processing tools. As a neuroimaging database represents a large volume of datasets and as neuroimaging processing pipelines are composed of heterogeneous, computationally intensive tools, such open sharing raises specific computational challenges. This motivates the design of novel dedicated computing infrastructures. This paper describes an interface between PSOM, a code-oriented pipeline development framework, and CBRAIN, a web-oriented platform for grid computing. This interface was used to integrate a PSOM-compliant pipeline for preprocessing of structural and functional magnetic resonance imaging into CBRAIN. We further tested the capacity of our infrastructure to handle a real large-scale project. A neuroimaging database including close to 1000 subjects was preprocessed using our interface and publicly released to help the participants of the ADHD-200 international competition. This successful experiment demonstrated that our integrated grid-computing platform is a powerful solution for high-throughput pipeline analysis in the field of neuroimaging.

A bill to approve the Keystone XL Pipeline.

THOMAS, 113th Congress

Sen. Hoeven, John [R-ND

2014-05-01

Senate - 11/18/2014 Under the order of 11/12/14, not having achieved 60 votes in the affirmative, failed of passage in Senate by Yea-Nay Vote. 59 - 41. Record Vote Number: 280. (All Actions) Tracker: This bill has the status Failed SenateHere are the steps for Status of Legislation:

A bill to approve the Keystone XL Pipeline.

THOMAS, 112th Congress

Sen. Hoeven, John [R-ND

2012-09-20

Senate - 09/21/2012 Read the second time. Placed on Senate Legislative Calendar under General Orders. Calendar No. 533. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

A bill to approve the Keystone XL Pipeline.

THOMAS, 113th Congress

Sen. Hoeven, John [R-ND

2013-03-14

Senate - 03/18/2013 Read the second time. Placed on Senate Legislative Calendar under General Orders. Calendar No. 29. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Performance evaluation of high-strength steel pipelines for high-pressure gaseous hydrogen transportation.

DOT National Transportation Integrated Search

2009-01-01

Pipeline steels suffer significant degradation of their mechanical properties in high-pressure : gaseous hydrogen, including their fatigue cracking resistances to cyclic loading. The current : project work was conducted to produce fatigue crack growt...

77 FR 6857 - Pipeline Safety: Notice of Public Meetings on Improving Pipeline Leak Detection System...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-09

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket ID... installed to lessen the volume of natural gas and hazardous liquid released during catastrophic pipeline... p.m. Panel 3: Considerations for Natural Gas Pipeline Leak Detection Systems 3:30 p.m. Break 3:45 p...

Supersonic air jets preserve tree roots in underground pipeline installation

Treesearch

Rob Gross; Michelle Julene

2002-01-01

Tree roots are often damaged during construction projects, particularly during trenching operations for pipeline installation. Although mechanical soil excavation using heavy equipment, such as an excavator or backhoe is considered the fastest the most economical method, it damages and destroys tree roots and can lead to unintentional tree loss, poor public relations,...

Pegasus XL CYGNSS Second Launch Attempt, Drop & Launch of Rocket

NASA Image and Video Library

2016-12-15

The Orbital ATK Pegasus XL rocket carrying NASA's Cyclone Global Navigation Satellite System, or CYGNSS, spacecraft is released and the first stage ignites at 8:37 a.m. EST. The rocket was released from the Orbital ATK L-1011 Stargazer aircraft flying over the Atlantic Ocean offshore from Daytona Beach, Florida following takeoff from the Skid Strip at Cape Canaveral Air Force Station. This image was taken from a NASA F-18 chase plane provided by Armstrong Flight Research Center in California. The CYGNSS satellites will make frequent and accurate measurements of ocean surface winds throughout the life cycle of tropical storms and hurricanes.

Mobile hybrid LiDAR & infrared sensing for natural gas pipeline monitoring compendium.

DOT National Transportation Integrated Search

2016-01-01

This item consists of several documents that were created throughout the Mobile Hybrid LiDAR & Infrared Sensing for Natural Gas Pipeline Monitoring project, No. RITARS-14-H-RUT, which was conducted from January 15, 2014 to June 30, 2016. Documents in...

77 FR 45417 - Pipeline Safety: Inspection and Protection of Pipeline Facilities After Railway Accidents

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-31

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No... Accidents AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA); DOT. [[Page 45418

76 FR 28326 - Pipeline Safety: National Pipeline Mapping System Data Submissions and Submission Dates for Gas...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-17

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration 49 CFR 191... Reports AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Issuance of... Pipeline and Hazardous Materials Safety Administration (PHMSA) published a final rule on November 26, 2010...

Freight pipelines: Current status and anticipated future use

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-07-01

This report is issued by the Task Committee on Freight Pipelines, Pipeline Division, ASCE. Freight pipelines of various types (including slurry pipeline, pneumatic pipeline, and capsule pipeline) have been used throughout the world for over a century for transporting solid and sometimes even package products. Recent advancements in pipeline technology, aided by advanced computer control systems and trenchless technologies, have greatly facilitated the transportation of solids by pipelines. Today, in many situations, freight pipelines are not only the most economical and practical means for transporting solids, they are also the most reliable, safest and most environmentally friendly transportation mode. Increasedmore » use of underground pipelines to transport freight is anticipated in the future, especially as the technology continues to improve and surface transportation modes such as highways become more congested. This paper describes the state of the art and expected future uses of various types of freight pipelines. Obstacles hindering the development and use of the most advanced freight pipeline systems, such as the pneumatic capsule pipeline for interstate transport of freight, are discussed.« less

Indications for MARS-MRI in Patients Treated With Articular Surface Replacement XL Total Hip Arthroplasty.

PubMed

Connelly, James W; Galea, Vincent P; Laaksonen, Inari; Matuszak, Sean J; Madanat, Rami; Muratoglu, Orhun; Malchau, Henrik

2018-04-19

The purpose of this study was to identify which patient and clinical factors are predictive of adverse local tissue reaction (ALTR) and to use these factors to create a highly sensitive algorithm for indicating metal artifact reduction sequence magnetic resonance imaging (MARS-MRI) in Articular Surface Replacement (ASR) XL total hip arthroplasty patients. Our secondary aim was to compare our algorithm to existing national guidelines on when to take MARS-MRI in metal-on-metal total hip arthroplasty patients. The study consisted of 137 patients treated with unilateral ASR XL implants from a prospective, multicenter study. Patients underwent MARS-MRI regardless of clinical presentation at a mean of 6.2 (range, 3.3-10.4) years from surgery. Univariate and multivariate analyses were conducted to determine which variables were predictive of ALTR. Predictors were used to create an algorithm to indicate MARS-MRI. Finally, we compared our algorithm's ability to detect ALTR to existing guidelines. We found a visual analog scale pain score ≥2 (odds ratio [OR] = 2.53; P = .023), high blood cobalt (OR = 1.05; P = .023), and male gender (OR = 2.37; P = .034) to be significant predictors of ALTR presence in our cohort. The resultant algorithm achieved 86.4% sensitivity and 60.2% specificity in detecting ALTR within our cohort. Our algorithm had the highest area under the curve and was the only guideline that was significantly predictive of ALTR (P = .014). Our algorithm including patient-reported pain and sex-specific cutoffs for blood cobalt levels could predict ALTR and indicate MARS-MRI in our cohort of ASR XL metal-on-metal patients with high sensitivity. Level II, diagnostic study. Copyright © 2018 Elsevier Inc. All rights reserved.

Astronomy Legacy Project - Pisgah Astronomical Research Institute

NASA Astrophysics Data System (ADS)

Barker, Thurburn; Castelaz, Michael W.; Rottler, Lee; Cline, J. Donald

2016-01-01

Pisgah Astronomical Research Institute (PARI) is a not-for-profit public foundation in North Carolina dedicated to providing hands-on educational and research opportunities for a broad cross-section of users in science, technology, engineering and math (STEM) disciplines. In November 2007 a Workshop on a National Plan for Preserving Astronomical Photographic Data (2009ASPC,410,33O, Osborn, W. & Robbins, L) was held at PARI. The result was the establishment of the Astronomical Photographic Data Archive (APDA) at PARI. In late 2013 PARI began ALP (Astronomy Legacy Project). ALP's purpose is to digitize an extensive set of twentieth century photographic astronomical data housed in APDA. Because of the wide range of types of plates, plate dimensions and emulsions found among the 40+ collections, plate digitization will require a versatile set of scanners and digitizing instruments. Internet crowdfunding was used to assist in the purchase of additional digitization equipment that were described at AstroPlate2014 Plate Preservation Workshop (www.astroplate.cz) held in Prague, CZ, March, 2014. Equipment purchased included an Epson Expression 11000XL scanner and two Nikon D800E cameras. These digital instruments will compliment a STScI GAMMA scanner now located in APDA. GAMMA will be adapted to use an electroluminescence light source and a digital camera with a telecentric lens to achieve high-speed high-resolution scanning. The 1μm precision XY stage of GAMMA will allow very precise positioning of the plate stage. Multiple overlapping CCD images of small sections of each plate, tiles, will be combined using a photo-mosaic process similar to one used in Harvard's DASCH project. Implementation of a software pipeline for the creation of a SQL database containing plate images and metadata will be based upon APPLAUSE as described by Tuvikene at AstroPlate2014 (www.astroplate.cz/programs/).

Illumina GA IIx& HiSeq 2000 Production Sequenccing and QC Analysis Pipelines at the DOE Joint Genome Institute

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daum, Christopher; Zane, Matthew; Han, James

2011-01-31

The U.S. Department of Energy (DOE) Joint Genome Institute's (JGI) Production Sequencing group is committed to the generation of high-quality genomic DNA sequence to support the mission areas of renewable energy generation, global carbon management, and environmental characterization and clean-up. Within the JGI's Production Sequencing group, a robust Illumina Genome Analyzer and HiSeq pipeline has been established. Optimization of the sesequencer pipelines has been ongoing with the aim of continual process improvement of the laboratory workflow, reducing operational costs and project cycle times to increases ample throughput, and improving the overall quality of the sequence generated. A sequence QC analysismore » pipeline has been implemented to automatically generate read and assembly level quality metrics. The foremost of these optimization projects, along with sequencing and operational strategies, throughput numbers, and sequencing quality results will be presented.« less

What Was Learned in Predicting Slender Airframe Aerodynamics with the F16-XL Aircraft

NASA Technical Reports Server (NTRS)

Rizzi, Arthur; Lucking, James M.

2014-01-01

The CAWAPI-2 coordinated project has been underway to improve CFD predictions of slender airframe aerodynamics. The work is focused on two flow conditions and leverages a unique flight data set obtained with the F-16XL aircraft for comparison and verification. These conditions, a low-speed high angle-of-attack case and a transonic low angle-of-attack case, were selected from a prior prediction campaign wherein the CFD failed to provide acceptable results. In re-visiting these two cases, approaches for improved results include better, denser grids using more grid adaptation to local flow features as well as unsteady higher-fidelity physical modeling like hybrid RANS/URANS-LES methods. The work embodies predictions from multiple numerical formulations that are contributed from multiple organizations where some authors investigate other possible factors that could explain the discrepancies in agreement, e.g. effects due to deflected control surfaces during the flight tests, as well as static aeroelastic deflection of the outer wing. This paper presents the synthesis of all the results and findings and draws some conclusions that lead to an improved understanding of the underlying flow physics, and finally making the connections between the physics and aircraft features.

Controlled attenuation parameter using the FibroScan® XL probe for quantification of hepatic steatosis for non-alcoholic fatty liver disease in an Asian population.

PubMed

Chan, Wah-Kheong; Nik Mustapha, Nik Raihan; Wong, Grace Lai-Hung; Wong, Vincent Wai-Sun; Mahadeva, Sanjiv

2017-02-01

The FibroScan® XL probe reduces failure of liver stiffness measurement (LSM) and unreliable results in obese patients. The objective of this article is to evaluate the accuracy of controlled attenuation parameter (CAP) obtained using the XL probe for the estimation of hepatic steatosis in patients with non-alcoholic fatty liver disease (NAFLD). Adult NAFLD patients with a liver biopsy within six months were included and were examined with the FibroScan® M and XL probes. Histopathological findings were reported according to the Non-Alcoholic Steatohepatitis Clinical Research Network Scoring System. Participants who did not have fatty liver on ultrasonography were recruited as controls. A total of 57 NAFLD patients and 22 controls were included. The mean age of the NAFLD patients and controls was 50.1 ± 10.4 years and 20.2 ± 1.3 years, respectively ( p  = 0.000). The mean body mass index was 30.2 ± 5.0 kg per m 2 and 20.5 ± 2.4 kg per m 2 , respectively ( p  = 0.000). The distribution of steatosis grades were: S0, 29%; S1, 17%; S2, 35%; S3, 19%. The AUROC for estimation of steatosis grade ≥ S1, S2 and S3 was 0.94, 0.80 and 0.69, respectively, using the M probe, and 0.97, 0.81 and 0.67, respectively, using the XL probe. CAP obtained using the XL probe had similar accuracy as the M probe for the estimation of hepatic steatosis in NAFLD patients.

Lateral instability of high temperature pipelines, the 20-in. Sleipner Vest pipeline

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saevik, S.; Levold, E.; Johnsen, O.K.

1996-12-01

The present paper addresses methods to control snaking behavior of high temperature pipelines resting on a flat sea bed. A case study is presented based on the detail engineering of the 12.5 km long 20 inch gas pipeline connecting the Sleipner Vest wellhead platform to the Sleipner T processing platform in the North Sea. The study includes screening and evaluation of alternative expansion control methods, ending up with a recommended method. The methodology and philosophy, used as basis to ensure sufficient structural strength throughout the lifetime of the pipeline, are thereafter presented. The results show that in order to findmore » the optimum technical solution to control snaking behavior, many aspects need to be considered such as process requirements, allowable strain, hydrodynamic stability, vertical profile, pipelay installation and trawlboard loading. It is concluded that by proper consideration of all the above aspects, the high temperature pipeline can be designed to obtain sufficient safety level.« less

Clinical performance of the novel DiaSorin LIAISON(®) XL murex: HBsAg Quant, HCV-Ab, HIV-Ab/Ag assays.

PubMed

Krawczyk, Adalbert; Hintze, Christian; Ackermann, Jessica; Goitowski, Birgit; Trippler, Martin; Grüner, Nico; Neumann-Fraune, Maria; Verheyen, Jens; Fiedler, Melanie

2014-01-01

The fully automated and closed LIAISON(®)XL platform was developed for reliable detection of infection markers like hepatitis B virus (HBV) surface antigen (HBsAg), hepatitis C virus (HCV) antibodies (Ab) or human immunodeficiency virus (HIV)-Ag/Ab. To date, less is known about the diagnostic performance of this system in direct comparison to the common Abbott ARCHITECT(®) platform. We compared the diagnostic performance and usability of the DiaSorin LIAISON(®)XL with the commonly used Abbott ARCHITECT(®) system. The qualitative performance of the above mentioned assays was compared in about 500 sera. Quantitative tests were performed for HBsAg-positive samples from patients under therapy (n=289) and in vitro expressed mutants (n=37). For HCV-Ab, a total number of 155 selected samples from patients chronically infected with different HCV genotypes were tested. The concordance between both systems was 99.4% for HBsAg, 98.81% for HCV-Ab, and 99.6% for HIV-Ab/Ag. The quantitative LIAISON(®)XL murex HBsAg assay detected all mutants in comparable amounts to the HBsAg wild type and yielded highly reliable HBsAg kinetics in patients treated with antiviral drugs. Dilution experiments using the 2nd International Standard for HBsAg (WHO) showed a high accuracy of this test. HCV-Ab from patients infected with genotypes 1-3 were equally detected in both systems. Interestingly, S/CO levels of HCV-Ab from patients infected with genotype 3 seem to be relatively low using both systems. The LIAISON(®)XL platform proved to be an excellent system for diagnostics of HBV, HCV, and HIV with equal performance compared to the ARCHITECT(®) system. Copyright © 2013 Elsevier B.V. All rights reserved.

Polysaccharides from the Chinese medicinal herb Achyranthes bidentata enhance anti-malarial immunity during Plasmodium yoelii 17XL infection in mice.

PubMed

Zhu, Xiaotong; Pan, Yanyan; Zheng, Li; Cui, Liwang; Cao, Yaming

2012-02-20

Clinical immunity to malaria in human populations is developed after repeated exposure to malaria. Regulation and balance of host immune responses may lead to optimal immunity against malaria parasite infection. Polysaccharides (ABPS) derived from the Chinese herb ox knee Achyranthes bidentata possess immuno-modulatory functions. The aim of this study is to use the rodent malaria model Plasmodium yoelii 17XL (P. y17XL) to examine whether pretreatment with ABPS will modulate host immunity against malaria infection and improve the outcome of the disease. To determine whether ABPS could modulate immunity against malaria, mice were pretreated with ABPS prior to blood-stage infection by P. y17XL. Host survival and parasitaemia were monitored daily. The effect of pretreatment on host immune responses was studied through the quantitation of cytokines, dendritic cell populations, and natural regulatory T cells (Treg). Pretreatment with ABPS prior to infection significantly extended the survival time of mice after P. y17XL infection. At three and five days post-infection, ABPS pretreated mice developed stronger Th1 immune responses against malaria infection with the number of F4/80+CD36+ macrophages and levels of IFN-γ, TNF-α and nitric oxide being significantly higher than in the control group. More importantly, ABPS-treated mice developed more myeloid (CD11c+CD11b+) and plasmacytoid dendritic cells (CD11c+CD45R+/B220+) than control mice. ABPS pretreatment also resulted in modulated expression of MHC-II, CD86, and especially Toll-like receptor 9 by CD11c+ dendritic cells. In comparison, pretreatment with ABPS did not alter the number of natural Treg or the production of the anti-inflammatory cytokine IL-10. Pretreatment with the immuno-modulatory ABPS selectively enhanced Th1 immune responses to control the proliferation of malaria parasites, and prolonged the survival of mice during subsequent malaria infection.

Behavior of Solvent-Exposed Hydrophobic Groove in the Anti-Apoptotic Bcl-XL Protein: Clues for Its Ability to Bind Diverse BH3 Ligands from MD Simulations

PubMed Central

Sankararamakrishnan, Ramasubbu

2013-01-01

Bcl-XL is a member of Bcl-2 family of proteins involved in the regulation of intrinsic pathway of apoptosis. Its overexpression in many human cancers makes it an important target for anti-cancer drugs. Bcl-XL interacts with the BH3 domain of several pro-apoptotic Bcl-2 partners. This helical bundle protein has a pronounced hydrophobic groove which acts as a binding region for the BH3 domains. Eight independent molecular dynamics simulations of the apo/holo forms of Bcl-XL were carried out to investigate the behavior of solvent-exposed hydrophobic groove. The simulations used either a twin-range cut-off or particle mesh Ewald (PME) scheme to treat long-range interactions. Destabilization of the BH3 domain-containing helix H2 was observed in all four twin-range cut-off simulations. Most of the other major helices remained stable. The unwinding of H2 can be related to the ability of Bcl-XL to bind diverse BH3 ligands. The loss of helical character can also be linked to the formation of homo- or hetero-dimers in Bcl-2 proteins. Several experimental studies have suggested that exposure of BH3 domain is a crucial event before they form dimers. Thus unwinding of H2 seems to be functionally very important. The four PME simulations, however, revealed a stable helix H2. It is possible that the H2 unfolding might occur in PME simulations at longer time scales. Hydrophobic residues in the hydrophobic groove are involved in stable interactions among themselves. The solvent accessible surface areas of bulky hydrophobic residues in the groove are significantly buried by the loop LB connecting the helix H2 and subsequent helix. These observations help to understand how the hydrophobic patch in Bcl-XL remains stable in the solvent-exposed state. We suggest that both the destabilization of helix H2 and the conformational heterogeneity of loop LB are important factors for binding of diverse ligands in the hydrophobic groove of Bcl-XL. PMID:23468841

KAnalyze: a fast versatile pipelined K-mer toolkit

PubMed Central

Audano, Peter; Vannberg, Fredrik

2014-01-01

Motivation: Converting nucleotide sequences into short overlapping fragments of uniform length, k-mers, is a common step in many bioinformatics applications. While existing software packages count k-mers, few are optimized for speed, offer an application programming interface (API), a graphical interface or contain features that make it extensible and maintainable. We designed KAnalyze to compete with the fastest k-mer counters, to produce reliable output and to support future development efforts through well-architected, documented and testable code. Currently, KAnalyze can output k-mer counts in a sorted tab-delimited file or stream k-mers as they are read. KAnalyze can process large datasets with 2 GB of memory. This project is implemented in Java 7, and the command line interface (CLI) is designed to integrate into pipelines written in any language. Results: As a k-mer counter, KAnalyze outperforms Jellyfish, DSK and a pipeline built on Perl and Linux utilities. Through extensive unit and system testing, we have verified that KAnalyze produces the correct k-mer counts over multiple datasets and k-mer sizes. Availability and implementation: KAnalyze is available on SourceForge: https://sourceforge.net/projects/kanalyze/ Contact: fredrik.vannberg@biology.gatech.edu Supplementary information: Supplementary data are available at Bioinformatics online. PMID:24642064

The Hyper Suprime-Cam software pipeline

NASA Astrophysics Data System (ADS)

Bosch, James; Armstrong, Robert; Bickerton, Steven; Furusawa, Hisanori; Ikeda, Hiroyuki; Koike, Michitaro; Lupton, Robert; Mineo, Sogo; Price, Paul; Takata, Tadafumi; Tanaka, Masayuki; Yasuda, Naoki; AlSayyad, Yusra; Becker, Andrew C.; Coulton, William; Coupon, Jean; Garmilla, Jose; Huang, Song; Krughoff, K. Simon; Lang, Dustin; Leauthaud, Alexie; Lim, Kian-Tat; Lust, Nate B.; MacArthur, Lauren A.; Mandelbaum, Rachel; Miyatake, Hironao; Miyazaki, Satoshi; Murata, Ryoma; More, Surhud; Okura, Yuki; Owen, Russell; Swinbank, John D.; Strauss, Michael A.; Yamada, Yoshihiko; Yamanoi, Hitomi

2018-01-01

In this paper, we describe the optical imaging data processing pipeline developed for the Subaru Telescope's Hyper Suprime-Cam (HSC) instrument. The HSC Pipeline builds on the prototype pipeline being developed by the Large Synoptic Survey Telescope's Data Management system, adding customizations for HSC, large-scale processing capabilities, and novel algorithms that have since been reincorporated into the LSST codebase. While designed primarily to reduce HSC Subaru Strategic Program (SSP) data, it is also the recommended pipeline for reducing general-observer HSC data. The HSC pipeline includes high-level processing steps that generate coadded images and science-ready catalogs as well as low-level detrending and image characterizations.

The inspection of a radiologically contaminated pipeline using a teleoperated pipe crawler

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fogle, R.F.; Kuelske, K.; Kellner, R.A.

1995-08-01

In the 1950s, the Savannah River Site built an open, unlined retention basin to temporarily store potentially radionuclide contaminated cooling water from a chemical separations process and storm water drainage from a nearby waste management facility that stored large quantities of nuclear fission byproducts in carbon steel tanks. The retention basin was retired from service in 1972 when a new, lined basin was completed. In 1978, the old retention basin was excavated, backfilled with uncontaminated dirt, and covered with grass. At the same time, much of the underground process pipeline leading to the basin was abandoned. Since the closure ofmore » the retention basin, new environmental regulations require that the basin undergo further assessment to determine whether additional remediation is required. A visual and radiological inspection of the pipeline was necessary to aid in the remediation decision making process for the retention basin system. A teleoperated pipe crawler inspection system was developed to survey the abandoned sections of underground pipelines leading to the retired retention basin. This paper will describe the background to this project, the scope of the investigation, the equipment requirements, and the results of the pipeline inspection.« less

Scaling-up NLP Pipelines to Process Large Corpora of Clinical Notes.

PubMed

Divita, G; Carter, M; Redd, A; Zeng, Q; Gupta, K; Trautner, B; Samore, M; Gundlapalli, A

2015-01-01

This article is part of the Focus Theme of Methods of Information in Medicine on "Big Data and Analytics in Healthcare". This paper describes the scale-up efforts at the VA Salt Lake City Health Care System to address processing large corpora of clinical notes through a natural language processing (NLP) pipeline. The use case described is a current project focused on detecting the presence of an indwelling urinary catheter in hospitalized patients and subsequent catheter-associated urinary tract infections. An NLP algorithm using v3NLP was developed to detect the presence of an indwelling urinary catheter in hospitalized patients. The algorithm was tested on a small corpus of notes on patients for whom the presence or absence of a catheter was already known (reference standard). In planning for a scale-up, we estimated that the original algorithm would have taken 2.4 days to run on a larger corpus of notes for this project (550,000 notes), and 27 days for a corpus of 6 million records representative of a national sample of notes. We approached scaling-up NLP pipelines through three techniques: pipeline replication via multi-threading, intra-annotator threading for tasks that can be further decomposed, and remote annotator services which enable annotator scale-out. The scale-up resulted in reducing the average time to process a record from 206 milliseconds to 17 milliseconds or a 12- fold increase in performance when applied to a corpus of 550,000 notes. Purposely simplistic in nature, these scale-up efforts are the straight forward evolution from small scale NLP processing to larger scale extraction without incurring associated complexities that are inherited by the use of the underlying UIMA framework. These efforts represent generalizable and widely applicable techniques that will aid other computationally complex NLP pipelines that are of need to be scaled out for processing and analyzing big data.

75 FR 19645 - Denali-The Alaska Gas Pipeline LLC; Notice of Request for Approval of Plan for Conducting an Open...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-15

... Alaska Gas Pipeline LLC; Notice of Request for Approval of Plan for Conducting an Open Season April 8... governing Open Seasons for Alaska Natural Gas Transportation Projects, Denali--The Alaska Gas Pipeline LLC (Denali) filed a Request for Commission Approval of its Plan for Conducting an Open Season. The proposed...

78 FR 53190 - Pipeline Safety: Notice to Operators of Hazardous Liquid and Natural Gas Pipelines of a Recall on...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-28

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2013-0185] Pipeline Safety: Notice to Operators of Hazardous Liquid and Natural Gas Pipelines of a Recall on Leak Repair Clamps Due to Defective Seal AGENCY: Pipeline and Hazardous Materials Safety...

DDBJ read annotation pipeline: a cloud computing-based pipeline for high-throughput analysis of next-generation sequencing data.

PubMed

Nagasaki, Hideki; Mochizuki, Takako; Kodama, Yuichi; Saruhashi, Satoshi; Morizaki, Shota; Sugawara, Hideaki; Ohyanagi, Hajime; Kurata, Nori; Okubo, Kousaku; Takagi, Toshihisa; Kaminuma, Eli; Nakamura, Yasukazu

2013-08-01

High-performance next-generation sequencing (NGS) technologies are advancing genomics and molecular biological research. However, the immense amount of sequence data requires computational skills and suitable hardware resources that are a challenge to molecular biologists. The DNA Data Bank of Japan (DDBJ) of the National Institute of Genetics (NIG) has initiated a cloud computing-based analytical pipeline, the DDBJ Read Annotation Pipeline (DDBJ Pipeline), for a high-throughput annotation of NGS reads. The DDBJ Pipeline offers a user-friendly graphical web interface and processes massive NGS datasets using decentralized processing by NIG supercomputers currently free of charge. The proposed pipeline consists of two analysis components: basic analysis for reference genome mapping and de novo assembly and subsequent high-level analysis of structural and functional annotations. Users may smoothly switch between the two components in the pipeline, facilitating web-based operations on a supercomputer for high-throughput data analysis. Moreover, public NGS reads of the DDBJ Sequence Read Archive located on the same supercomputer can be imported into the pipeline through the input of only an accession number. This proposed pipeline will facilitate research by utilizing unified analytical workflows applied to the NGS data. The DDBJ Pipeline is accessible at http://p.ddbj.nig.ac.jp/.

DDBJ Read Annotation Pipeline: A Cloud Computing-Based Pipeline for High-Throughput Analysis of Next-Generation Sequencing Data

PubMed Central

Nagasaki, Hideki; Mochizuki, Takako; Kodama, Yuichi; Saruhashi, Satoshi; Morizaki, Shota; Sugawara, Hideaki; Ohyanagi, Hajime; Kurata, Nori; Okubo, Kousaku; Takagi, Toshihisa; Kaminuma, Eli; Nakamura, Yasukazu

2013-01-01

High-performance next-generation sequencing (NGS) technologies are advancing genomics and molecular biological research. However, the immense amount of sequence data requires computational skills and suitable hardware resources that are a challenge to molecular biologists. The DNA Data Bank of Japan (DDBJ) of the National Institute of Genetics (NIG) has initiated a cloud computing-based analytical pipeline, the DDBJ Read Annotation Pipeline (DDBJ Pipeline), for a high-throughput annotation of NGS reads. The DDBJ Pipeline offers a user-friendly graphical web interface and processes massive NGS datasets using decentralized processing by NIG supercomputers currently free of charge. The proposed pipeline consists of two analysis components: basic analysis for reference genome mapping and de novo assembly and subsequent high-level analysis of structural and functional annotations. Users may smoothly switch between the two components in the pipeline, facilitating web-based operations on a supercomputer for high-throughput data analysis. Moreover, public NGS reads of the DDBJ Sequence Read Archive located on the same supercomputer can be imported into the pipeline through the input of only an accession number. This proposed pipeline will facilitate research by utilizing unified analytical workflows applied to the NGS data. The DDBJ Pipeline is accessible at http://p.ddbj.nig.ac.jp/. PMID:23657089

77 FR 19414 - Pipeline Safety: Public Comment on Leak and Valve Studies Mandated by the Pipeline Safety...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-30

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket ID... Safety, Regulatory Certainty, and Job Creation Act of 2011 AGENCY: Pipeline and Hazardous Materials... Transportation (DOT), Pipeline and Hazardous Materials Safety Administration (PHMSA) is providing an important...

Environmental impact analysis; the example of the proposed Trans-Alaska Pipeline

USGS Publications Warehouse

Brew, David A.

1974-01-01

The environmental impact analysis made as required by the National Environmental Policy Act of 1969 for the proposed trans-Alaska pipeline included consideration of the (1) technologically complex and geographically extensive proposed project, (2) extremely different physical environments across Alaska along the proposed route and elsewhere in Alaska and in Canada along alternative routes, (3) socioeconomic environment of the State of Alaska, and (4) a wide variety of alternatives. The analysis was designed specifically to fit the project and environment that would be affected. The environment was divided into two general parts--natural physical systems and superposed socioeconomic systems--and those parts were further divided into discipline-oriented systems or components that were studied and analyzed by scientists of the appropriate discipline. Particular attention was given to potential feedback loops in the impact network and to linkages between the project's impacting effects and the environment. The results of the analysis as reported in the final environmental impact statement were that both unavoidable and threatened environmental impacts would result from construction, operation, and maintenance of the proposed pipeline system and the developments related to it. The principal unavoidable effects would be (1) disturbances of terrain, fish and wildlife habitat, and human environs, (2) the results of the discharge of effluent from the tanker-ballast-treatment facility into Port Valdez and of some indeterminate amount of oil released into the ocean from tank-cleaning operations at sea, and (3) the results associated with increased human pressures of all kinds on the environment. Other unavoidable effects would be those related to increase of State and Native Corporation revenues, accelerated cultural change of the Native population, and extraction of the oil and gas resource. The main threatened environmental effects would all be related to unintentional oil

[Behavior in the forced-swimming test and expression of BDNF and Bcl-xl genes in the rat brain].

PubMed

Berezova, I V; Shishkina, G T; Kalinina, T S; Dygalo, N N

2011-01-01

A single exposure of rats to the forced-swimming stress decreased BDNF mRNA levels in the cortex and increased Bcl-xl gene expression in the hippocampus and amygdala 24 h after the stress. The animals demonstrated a depressive-like behavior and elevated blood corticosterone level. There was a significant negative correlation between BDNF mRNA level in the cortex and immobility time during swimming. Repeated exposure to swimming stress caused the elevation of the hippocampal BDNF mRNA level assessed 24 h after the second swimming session. The data suggest that stress-induced down-regulation of cortical BDNF gene expression and behavioral despair in the forced-swimming test may be interrelated. The increase in the BDNF and Bcl-xl mRNA levels may contribute to the mechanisms protecting the brain against negative effects of stress.

Putting the environment into the NPV calculation -- Quantifying pipeline environmental costs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dott, D.R.; Wirasinghe, S.C.; Chakma, A.

1996-12-31

Pipeline projects impact the environment through soil and habitat disturbance, noise during construction and compressor operation, river crossing disturbance and the risk of rupture. Assigning monetary value to these negative project consequences enables the environment to be represented in the project cost-benefit analysis. This paper presents the mechanics and implications of two environmental valuation techniques: (1) the contingent valuation method and (2) the stated preference method. The use of environmental value at the project economic-evaluation stage is explained. A summary of research done on relevant environmental attribute valuation is presented and discussed. Recommendations for further research in the field aremore » made.« less

The Hyper Suprime-Cam software pipeline

DOE PAGES

Bosch, James; Armstrong, Robert; Bickerton, Steven; ...

2017-10-12

Here in this article, we describe the optical imaging data processing pipeline developed for the Subaru Telescope’s Hyper Suprime-Cam (HSC) instrument. The HSC Pipeline builds on the prototype pipeline being developed by the Large Synoptic Survey Telescope’s Data Management system, adding customizations for HSC, large-scale processing capabilities, and novel algorithms that have since been reincorporated into the LSST codebase. While designed primarily to reduce HSC Subaru Strategic Program (SSP) data, it is also the recommended pipeline for reducing general-observer HSC data. The HSC pipeline includes high-level processing steps that generate coadded images and science-ready catalogs as well as low-level detrendingmore » and image characterizations.« less

The Hyper Suprime-Cam software pipeline

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bosch, James; Armstrong, Robert; Bickerton, Steven

Here in this article, we describe the optical imaging data processing pipeline developed for the Subaru Telescope’s Hyper Suprime-Cam (HSC) instrument. The HSC Pipeline builds on the prototype pipeline being developed by the Large Synoptic Survey Telescope’s Data Management system, adding customizations for HSC, large-scale processing capabilities, and novel algorithms that have since been reincorporated into the LSST codebase. While designed primarily to reduce HSC Subaru Strategic Program (SSP) data, it is also the recommended pipeline for reducing general-observer HSC data. The HSC pipeline includes high-level processing steps that generate coadded images and science-ready catalogs as well as low-level detrendingmore » and image characterizations.« less

F-16XL Ship #2 Laminar Flow Glove mounting

NASA Technical Reports Server (NTRS)

1995-01-01

NASA's two-seat F-16XL research aircraft is shown in the modification hangar at NASA's Dryden Flight Research Center, Edwards, California, during installation of a titanium 'glove' on the upper surface of its modified left wing. The aircraft subsequently carried out a 13-month-long, 45-flight research program which investigated drawing off a small part of the boundary-layer air in order to provide laminar--or smooth--flow over a major portion of a wing flying at supersonic speeds. A turbo-compressor in the aircraft's fuselage provided suction to draw air through more than 10 million tiny laser-drilled holes in the glove via a manifold system employing 20 valves. Data obtained during the program could assist designers of future aircraft in developing a more efficient high-speed civil transport.

A De-Novo Genome Analysis Pipeline (DeNoGAP) for large-scale comparative prokaryotic genomics studies.

PubMed

Thakur, Shalabh; Guttman, David S

2016-06-30

Comparative analysis of whole genome sequence data from closely related prokaryotic species or strains is becoming an increasingly important and accessible approach for addressing both fundamental and applied biological questions. While there are number of excellent tools developed for performing this task, most scale poorly when faced with hundreds of genome sequences, and many require extensive manual curation. We have developed a de-novo genome analysis pipeline (DeNoGAP) for the automated, iterative and high-throughput analysis of data from comparative genomics projects involving hundreds of whole genome sequences. The pipeline is designed to perform reference-assisted and de novo gene prediction, homolog protein family assignment, ortholog prediction, functional annotation, and pan-genome analysis using a range of proven tools and databases. While most existing methods scale quadratically with the number of genomes since they rely on pairwise comparisons among predicted protein sequences, DeNoGAP scales linearly since the homology assignment is based on iteratively refined hidden Markov models. This iterative clustering strategy enables DeNoGAP to handle a very large number of genomes using minimal computational resources. Moreover, the modular structure of the pipeline permits easy updates as new analysis programs become available. DeNoGAP integrates bioinformatics tools and databases for comparative analysis of a large number of genomes. The pipeline offers tools and algorithms for annotation and analysis of completed and draft genome sequences. The pipeline is developed using Perl, BioPerl and SQLite on Ubuntu Linux version 12.04 LTS. Currently, the software package accompanies script for automated installation of necessary external programs on Ubuntu Linux; however, the pipeline should be also compatible with other Linux and Unix systems after necessary external programs are installed. DeNoGAP is freely available at https://sourceforge.net/projects/denogap/ .

The Very Large Array Data Processing Pipeline

NASA Astrophysics Data System (ADS)

Kent, Brian R.; Masters, Joseph S.; Chandler, Claire J.; Davis, Lindsey E.; Kern, Jeffrey S.; Ott, Juergen; Schinzel, Frank K.; Medlin, Drew; Muders, Dirk; Williams, Stewart; Geers, Vincent C.; Momjian, Emmanuel; Butler, Bryan J.; Nakazato, Takeshi; Sugimoto, Kanako

2018-01-01

We present the VLA Pipeline, software that is part of the larger pipeline processing framework used for the Karl G. Jansky Very Large Array (VLA), and Atacama Large Millimeter/sub-millimeter Array (ALMA) for both interferometric and single dish observations.Through a collection of base code jointly used by the VLA and ALMA, the pipeline builds a hierarchy of classes to execute individual atomic pipeline tasks within the Common Astronomy Software Applications (CASA) package. Each pipeline task contains heuristics designed by the team to actively decide the best processing path and execution parameters for calibration and imaging. The pipeline code is developed and written in Python and uses a "context" structure for tracking the heuristic decisions and processing results. The pipeline "weblog" acts as the user interface in verifying the quality assurance of each calibration and imaging stage. The majority of VLA scheduling blocks above 1 GHz are now processed with the standard continuum recipe of the pipeline and offer a calibrated measurement set as a basic data product to observatory users. In addition, the pipeline is used for processing data from the VLA Sky Survey (VLASS), a seven year community-driven endeavor started in September 2017 to survey the entire sky down to a declination of -40 degrees at S-band (2-4 GHz). This 5500 hour next-generation large radio survey will explore the time and spectral domains, relying on pipeline processing to generate calibrated measurement sets, polarimetry, and imaging data products that are available to the astronomical community with no proprietary period. Here we present an overview of the pipeline design philosophy, heuristics, and calibration and imaging results produced by the pipeline. Future development will include the testing of spectral line recipes, low signal-to-noise heuristics, and serving as a testing platform for science ready data products.The pipeline is developed as part of the CASA software package by an

Improved coal-slurry pipeline

NASA Technical Reports Server (NTRS)

Dowler, W. L.

1979-01-01

High strength steel pipeline carries hot mixture of powdered coal and coal derived oil to electric-power-generating station. Slurry is processed along way to remove sulfur, ash, and nitrogen and to recycle part of oil. System eliminates hazards and limitations associated with anticipated coal/water-slurry pipelines.

drPACS: A Simple UNIX Execution Pipeline

NASA Astrophysics Data System (ADS)

Teuben, P.

2011-07-01

We describe a very simple yet flexible and effective pipeliner for UNIX commands. It creates a Makefile to define a set of serially dependent commands. The commands in the pipeline share a common set of parameters by which they can communicate. Commands must follow a simple convention to retrieve and store parameters. Pipeline parameters can optionally be made persistent across multiple runs of the pipeline. Tools were added to simplify running a large series of pipelines, which can then also be run in parallel.

77 FR 58826 - Cheniere Creole Trail Pipeline, L.P.; Notice of Availability of the Environmental Assessment for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-24

... Creole Trail Pipeline, L.P.; Notice of Availability of the Environmental Assessment for the Proposed Creole Trail Expansion Project The staff of the Federal Energy Regulatory Commission (FERC or Commission) has prepared an environmental assessment (EA) for the Creole Trail Expansion Project, proposed by...

77 FR 36525 - Cheniere Creole Trail Pipeline Company, L.P.; Notice of Intent To Prepare an Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-19

... Creole Trail Pipeline Company, L.P.; Notice of Intent To Prepare an Environmental Assessment for the Proposed Creole Trail Expansion Project and Request for Comments on Environmental Issues The staff of the...) that will discuss the environmental impacts of the Creole Trail Expansion Project involving...

F-16XL Ship #2 wing glove close-up, laser cut holes, with dime for scale

NASA Technical Reports Server (NTRS)

1995-01-01

This June 1995 photograph of a test panel similiar to the one attached to the surface of an F-16XL research aircraft's left wing at NASA's Dryden Flight Research Center, Edwards, California, shows the size of the more than 10 million laser-cut holes in the panel, called a glove, as compared with a dime. Below the titanium panel into which holes are cut is a suction system linked to a compressor. During research flights with the modified, delta-winged F-16XL, the suction system pulled a small part of the boundary layer of air through the glove's porous surface to expand the extent of smooth (laminar) flow. Researchers believe that laminar flow conditions can reduce aerodynamic drag (friction) and contribute to reduced operating costs by improving fuel consumption and lowering aircraft weight. This Supersonic Laminar Flow Control (SLFC) experiment represents a collaborative effort between NASA and aerospace industry (specifically Boeing, Rockwell, and McDonnell Douglas), with Boeing assembling the panel and McDonnell Douglas designing the suction system.

Acoustic system for communication in pipelines

DOEpatents

Martin, II, Louis Peter; Cooper, John F [Oakland, CA

2008-09-09

A system for communication in a pipe, or pipeline, or network of pipes containing a fluid. The system includes an encoding and transmitting sub-system connected to the pipe, or pipeline, or network of pipes that transmits a signal in the frequency range of 3-100 kHz into the pipe, or pipeline, or network of pipes containing a fluid, and a receiver and processor sub-system connected to the pipe, or pipeline, or network of pipes containing a fluid that receives said signal and uses said signal for a desired application.

L-1011 aircraft carrying a Pegasus XL (SORCE)

NASA Image and Video Library

2003-01-25

The L-1011 aircraft carrying a Pegasus XL rocket with NASA's Solar Radiation and Climate Experiment (SORCE) attached takes off from Cape Canaveral Air Force Station, Fla. The L-1011 will release the rocket over the Atlantic Ocean at 39,000 feet. After separation from the rocket, initial contact with the satellite will be made and the mission team will insure that the spacecraft is functioning properly. The SORCE science instruments will then be turned on and their health verified. Approximately 21 days after launch, if all is going well, the instruments will start initial science data collection and calibration will begin. The spacecraft will study the Sun's influence on our Earth and will measure from space how the Sun affects the Earth's ozone layer, atmospheric circulation, clouds, and oceans. This mission is a joint partnership between NASA and the University of Colorado's Laboratory for Atmospheric and Space Physics in Boulder, Colorado.

75 FR 3221 - Ruby Pipeline, L.L.C.; Notice of Availability of the Final Environmental Impact Statement for the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-20

... effects of the construction and operation of the following project facilities: About 675.2 miles of 42... any of the following methods: Web site: http://www.blm.gov/nv/st/en/info/nepa/ruby_pipeline_project...

CFHT data processing and calibration ESPaDOnS pipeline: Upena and OPERA (optical spectropolarimetry)

NASA Astrophysics Data System (ADS)

Martioli, Eder; Teeple, D.; Manset, Nadine

2011-03-01

CFHT is ESPaDOnS responsible for processing raw images, removing instrument related artifacts, and delivering science-ready data to the PIs. Here we describe the Upena pipeline, which is the software used to reduce the echelle spectro-polarimetric data obtained with the ESPaDOnS instrument. Upena is an automated pipeline that performs calibration and reduction of raw images. Upena has the capability of both performing real-time image-by-image basis reduction and a post observing night complete reduction. Upena produces polarization and intensity spectra in FITS format. The pipeline is designed to perform parallel computing for improved speed, which assures that the final products are delivered to the PIs before noon HST after each night of observations. We also present the OPERA project, which is an open-source pipeline to reduce ESPaDOnS data that will be developed as a collaborative work between CFHT and the scientific community. OPERA will match the core capabilities of Upena and in addition will be open-source, flexible and extensible.

Magnetic pipeline for coal and oil

DOE Office of Scientific and Technical Information (OSTI.GOV)

Knolle, E.

1998-07-01

A 1994 analysis of the recorded costs of the Alaska oil pipeline, in a paper entitled Maglev Crude Oil Pipeline, (NASA CP-3247 pp. 671--684) concluded that, had the Knolle Magnetrans pipeline technology been available and used, some $10 million per day in transportation costs could have been saved over the 20 years of the Alaska oil pipeline's existence. This over 800 mile long pipeline requires about 500 horsepower per mile in pumping power, which together with the cost of the pipeline's capital investment consumes about one-third of the energy value of the pumped oil. This does not include the costmore » of getting the oil out of the ground. The reason maglev technology performs superior to conventional pipelines is because by magnetically levitating the oil into contact-free suspense, there is no drag-causing adhesion. In addition, by using permanent magnets in repulsion, suspension is achieved without using energy. Also, the pumped oil's adhesion to the inside of pipes limits its speed. In the case of the Alaska pipeline the speed is limited to about 7 miles per hour, which, with its 48-inch pipe diameter and 1200 psi pressure, pumps about 2 million barrels per day. The maglev system, as developed by Knolle Magnetrans, would transport oil in magnetically suspended sealed containers and, thus free of adhesion, at speeds 10 to 20 times faster. Furthermore, the diameter of the levitated containers can be made smaller with the same capacity, which makes the construction of the maglev system light and inexpensive. There are similar advantages when using maglev technology to transport coal. Also, a maglev system has advantages over railroads in mountainous regions where coal is primarily mined. A maglev pipeline can travel, all-year and all weather, in a straight line to the end-user, whereas railroads have difficult circuitous routes. In contrast, a maglev pipeline can climb over steep hills without much difficulty.« less

The visual and radiological inspection of a pipeline using a teleoperated pipe crawler

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fogle, R.F.; Kuelske, K.; Kellner, R.

1995-01-01

In the 1950s, the Savannah River Site built an open, unlined retention basin to temporarily store potentially radionuclide contaminated cooling water from a chemical separations process and storm water drainage from a nearby waste management facility that stored large quantities of nuclear fission byproducts in carbon steel tanks. The retention basin was retired from service in 1972 when a new, lined basin was completed. In 1978, the old retention basin was excavated, backfilled with uncontaminated dirt, and covered with grass. At the same time, much of the underground process pipeline leading to the basin was abandoned. Since the closure ofmore » the retention basin, new environmental regulations require that the basin undergo further assessment to determine whether additional remediation is required. A visual and radiological inspection of the pipeline was necessary to aid in the remediation decision making process for the retention basin system. A teleoperated pipe crawler inspection system was developed to survey the abandoned sections of underground pipelines leading to the retired retention basin. This paper will describe the background to this project, the scope of the investigation, the equipment requirements, and the results of the pipeline inspection.« less

Comparisons of sediment losses from a newly constructed cross-country natural gas pipeline and an existing in-road pipeline

Treesearch

Pamela J. Edwards; Bridget M. Harrison; Daniel J. Holz; Karl W.J. Williard; Jon E. Schoonover

2014-01-01

Sediment loads were measured for about one year from natural gas pipelines in two studies in north central West Virginia. One study involved a 1-year-old pipeline buried within the bed of a 25-year-old skid road, and the other involved a newly constructed cross-country pipeline. Both pipelines were the same diameter and were installed using similar trenching and...

77 FR 27279 - Pipeline Safety: Information Collection Activities

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-09

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No... collections relate to the pipeline integrity management requirements for gas transmission pipeline operators... Management in High Consequence Areas Gas Transmission Pipeline Operators. OMB Control Number: 2137-0610...

75 FR 53733 - Pipeline Safety: Information Collection Activities

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-01

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2010-0246] Pipeline Safety: Information Collection Activities AGENCY: Pipeline and Hazardous... liquefied natural gas, hazardous liquid, and gas transmission pipeline systems operated by a company. The...

77 FR 46155 - Pipeline Safety: Information Collection Activities

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-02

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No... collections relate to the pipeline integrity management requirements for gas transmission pipeline operators... Management in High Consequence Areas Gas Transmission Pipeline Operators. OMB Control Number: 2137-0610...

78 FR 46560 - Pipeline Safety: Class Location Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-01

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration 49 CFR Part... class location requirements for gas transmission pipelines. Section 5 of the Pipeline Safety, Regulatory... and, with respect to gas transmission pipeline facilities, whether applying IMP requirements to...

77 FR 15453 - Pipeline Safety: Information Collection Activities

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-15

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No... information collection titled, ``Gas Pipeline Safety Program Certification and Hazardous Liquid Pipeline... collection request that PHMSA will be submitting to OMB for renewal titled, ``Gas Pipeline Safety Program...

A Model for Oil-Gas Pipelines Cost Prediction Based on a Data Mining Process

NASA Astrophysics Data System (ADS)

Batzias, Fragiskos A.; Spanidis, Phillip-Mark P.

2009-08-01

This paper addresses the problems associated with the cost estimation of oil/gas pipelines during the elaboration of feasibility assessments. Techno-economic parameters, i.e., cost, length and diameter, are critical for such studies at the preliminary design stage. A methodology for the development of a cost prediction model based on Data Mining (DM) process is proposed. The design and implementation of a Knowledge Base (KB), maintaining data collected from various disciplines of the pipeline industry, are presented. The formulation of a cost prediction equation is demonstrated by applying multiple regression analysis using data sets extracted from the KB. Following the methodology proposed, a learning context is inductively developed as background pipeline data are acquired, grouped and stored in the KB, and through a linear regression model provide statistically substantial results, useful for project managers or decision makers.

Capsule injection system for a hydraulic capsule pipelining system

DOEpatents

Liu, Henry

1982-01-01

An injection system for injecting capsules into a hydraulic capsule pipelining system, the pipelining system comprising a pipeline adapted for flow of a carrier liquid therethrough, and capsules adapted to be transported through the pipeline by the carrier liquid flowing through the pipeline. The injection system comprises a reservoir of carrier liquid, the pipeline extending within the reservoir and extending downstream out of the reservoir, and a magazine in the reservoir for holding capsules in a series, one above another, for injection into the pipeline in the reservoir. The magazine has a lower end in communication with the pipeline in the reservoir for delivery of capsules from the magazine into the pipeline.

SIMPLEX: Cloud-Enabled Pipeline for the Comprehensive Analysis of Exome Sequencing Data

PubMed Central

Fischer, Maria; Snajder, Rene; Pabinger, Stephan; Dander, Andreas; Schossig, Anna; Zschocke, Johannes; Trajanoski, Zlatko; Stocker, Gernot

2012-01-01

In recent studies, exome sequencing has proven to be a successful screening tool for the identification of candidate genes causing rare genetic diseases. Although underlying targeted sequencing methods are well established, necessary data handling and focused, structured analysis still remain demanding tasks. Here, we present a cloud-enabled autonomous analysis pipeline, which comprises the complete exome analysis workflow. The pipeline combines several in-house developed and published applications to perform the following steps: (a) initial quality control, (b) intelligent data filtering and pre-processing, (c) sequence alignment to a reference genome, (d) SNP and DIP detection, (e) functional annotation of variants using different approaches, and (f) detailed report generation during various stages of the workflow. The pipeline connects the selected analysis steps, exposes all available parameters for customized usage, performs required data handling, and distributes computationally expensive tasks either on a dedicated high-performance computing infrastructure or on the Amazon cloud environment (EC2). The presented application has already been used in several research projects including studies to elucidate the role of rare genetic diseases. The pipeline is continuously tested and is publicly available under the GPL as a VirtualBox or Cloud image at http://simplex.i-med.ac.at; additional supplementary data is provided at http://www.icbi.at/exome. PMID:22870267

77 FR 68763 - Tennessee Gas Pipeline Company, L.L.C.; Notice of Intent To Prepare an Environmental Assessment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-16

... Pipeline Company, L.L.C.; Notice of Intent To Prepare an Environmental Assessment for the Proposed Rose... the environmental impacts of the Rose Lake Expansion Project involving the modification of compression... in northeastern Pennsylvania. The proposed Rose Lake Expansion Project includes the following...

77 FR 51848 - Pipeline Safety: Information Collection Activities

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-27

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No... Program for Gas Distribution Pipelines. DATES: Interested persons are invited to submit comments on or.... These regulations require operators of hazardous liquid pipelines and gas pipelines to develop and...

77 FR 26822 - Pipeline Safety: Verification of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-07

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2012-0068] Pipeline Safety: Verification of Records AGENCY: Pipeline and Hazardous Materials... issuing an Advisory Bulletin to remind operators of gas and hazardous liquid pipeline facilities to verify...

77 FR 74275 - Pipeline Safety: Information Collection Activities

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-13

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No.... These regulations require operators of hazardous liquid pipelines and gas pipelines to develop and... control room. Affected Public: Operators of both natural gas and hazardous liquid pipeline systems. Annual...

Reconstruction of gas distribution pipelines in MOZG in Poland using PE and PA pipes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Borowicz, W.; Podziemski, T.; Kramek, E.

1996-12-31

MOZG--Warsaw Regional Gas Distribution Company was established in 1856. Now it is one of six gas distribution companies in Poland. Due to steadily increasing safety demands, some of the pipelines will need reconstruction. The majority of the substandard piping is located in urban areas. The company wanted to gain experiences in applying reconstruction technologies using two different plastic materials polyethylene and polyamide. They also wanted to assess the technical and economic practicalities of performing relining processes. A PE project--large diameter polyethylene relining (450 mm) conducted in Warsaw in 1994/95 and PA projects--relining using polyamide pipes, projects conducted in Radom andmore » in Warsaw during 1993 and 1994 are the most interesting and representative for this kind of works. Thanks to the experience obtained whilst carrying out these projects, reconstruction of old gas pipelines has become routine. Now they often use polyethylene relining of smaller diameters and they continue both construction and reconstruction of gas network using PA pipes. This paper presents the accumulated knowledge showing the advantages and disadvantages of applied methods. It describes project design and implementation with details and reports on the necessary preparation work, on site job organization and the most common problems arising during the construction works.« less

The Leaking U.S. Educational Pipeline and Its Implications for the Future

ERIC Educational Resources Information Center

Torraco, Richard J.; Hamilton, David W.

2013-01-01

We examine the United States educational pipeline and the relationship between our nation's current educational policy, which results in the loss of substantial numbers of students from our education system, and the social and economic consequences of maintaining our current policies. Projections of changes in those moving through the educational…

INTERNAL REPAIR OF PIPELINES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robin Gordon; Bill Bruce; Nancy Porter

2003-05-01

The two broad categories of deposited weld metal repair and fiber-reinforced composite repair technologies were reviewed for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Preliminary test programs were developed for both deposited weld metal repairs and for fiber-reinforced composite repair. To date, all of the experimental work pertaining to the evaluation of potential repair methods has focused on fiber-reinforced composite repairs. Hydrostatic testing was also conducted on four pipeline sections with simulated corrosion damage: twomore » with composite liners and two without.« less

Pipeline monitoring with unmanned aerial vehicles

NASA Astrophysics Data System (ADS)

Kochetkova, L. I.

2018-05-01

Pipeline leakage during transportation of combustible substances leads to explosion and fire thus causing death of people and destruction of production and accommodation facilities. Continuous pipeline monitoring allows identifying leaks in due time and quickly taking measures for their elimination. The paper describes the solution of identification of pipeline leakage using unmanned aerial vehicles. It is recommended to apply the spectral analysis with input RGB signal to identify pipeline damages. The application of multi-zone digital images allows defining potential spill of oil hydrocarbons as well as possible soil pollution. The method of multi-temporal digital images within the visible region makes it possible to define changes in soil morphology for its subsequent analysis. The given solution is cost efficient and reliable thus allowing reducing timing and labor resources in comparison with other methods of pipeline monitoring.

75 FR 73160 - Pipeline Safety: Information Collection Activities

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-29

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No...-Related Conditions on Gas, Hazardous Liquid, and Carbon Dioxide Pipelines and Liquefied Natural Gas... Pipelines and Liquefied Natural Gas Facilities.'' The Pipeline Safety Laws (49 U.S.C. 60132) require each...

Creating Data that Never Die: Building a Spectrograph Data Pipeline in the Virtual Observatory Era

NASA Astrophysics Data System (ADS)

Mink, D. J.; Wyatt, W. F.; Roll, J. B.; Tokarz, S. P.; Conroy, M. A.; Caldwell, N.; Kurtz, M.; Geller, M. J.

2005-12-01

Data pipelines for modern complex astronomical instruments do not begin when the data is taken and end when it is delivered to the user. Information must flow between the observatory and the observer from the time a project is conceived and between the observatory and the world well past the time when the original observers have extracted all the information they want from the data. For the 300-fiber Hectospec low dispersion spectrograph on the MMT, the SAO Telescope Data Center is constructing a data pipeline which provides assistance from preparing and submitting observing proposals through observation, reduction, and analysis to publication and an afterlife in the Virtual Observatory. We will describe our semi-automatic pipeline and how it has evolved over the first nine months of operation.

18 CFR 157.37 - Project design.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Project design. 157.37... Seasons for Alaska Natural Gas Transportation Projects § 157.37 Project design. In reviewing any application for an Alaska natural gas pipeline project, the Commission will consider the extent to which a...

18 CFR 157.37 - Project design.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Project design. 157.37... Seasons for Alaska Natural Gas Transportation Projects § 157.37 Project design. In reviewing any application for an Alaska natural gas pipeline project, the Commission will consider the extent to which a...

Government Support for Synthetic Pipeline Gas Uncertain and Needs Attention.

DTIC Science & Technology

1982-05-14

coal gas. Tear Sheetii RECOMMENDATIONS GAO recommends that the Secretary of Energy - --establish a plan to guide future support of high-Btu coal...recognizes that there are basic dif- ferences expected from large and small scale research projects, GAO believes that the report recognizes these...transportation, including the pipeline system. In its price-setting, or ratemaking function, it represents the interests of gas customers, sometimes

F-16XL ship #1 CAWAP flight - alpha 10 degrees, beta -5 degrees, altitude 10,000 feet

NASA Technical Reports Server (NTRS)

1996-01-01

The single-seat F-16XL (ship #1) makes another run during the Cranked-Arrow Wing Aerodynamic Project (CAWAP) at Dryden Flight Research Center, Edwards, California. The modified airplane features a delta 'cranked-arrow' wing with strips of tubing along the leading edge to the trailing edge to sense static on the wing and obtain pressure distribution data. The right wing receives data on pressure distribution and the left wing has three types of instrumentation - preston tubes to measure local skin friction, boundary layer rakes to measure boundary layer profiles (the layer where the air interacts with the surfaces of a moving aircraft), and hot films to determine boundary layer transition locations. This photo shows the aircraft gathering data at an altitude of 10,000 feet, with an angle of attack of 10 degrees and a sideslip angle of -5 degrees. The program also gathered aero data on two wing planforms for NASA's High Speed Research Program. The first flight of CAWAP occurred on November 21, 1995, and the test program ended in April 1996.

Analysis pipelines and packages for Infinium HumanMethylation450 BeadChip (450k) data

PubMed Central

Morris, Tiffany J.; Beck, Stephan

2015-01-01

The Illumina HumanMethylation450 BeadChip has become a popular platform for interrogating DNA methylation in epigenome-wide association studies (EWAS) and related projects as well as resource efforts such as the International Cancer Genome Consortium (ICGC) and the International Human Epigenome Consortium (IHEC). This has resulted in an exponential increase of 450k data in recent years and triggered the development of numerous integrated analysis pipelines and stand-alone packages. This review will introduce and discuss the currently most popular pipelines and packages and is particularly aimed at new 450k users. PMID:25233806

Landslide and Land Subsidence Hazards to Pipelines

USGS Publications Warehouse

Baum, Rex L.; Galloway, Devin L.; Harp, Edwin L.

2008-01-01

Landslides and land subsidence pose serious hazards to pipelines throughout the world. Many existing pipeline corridors and more and more new pipelines cross terrain that is affected by either landslides, land subsidence, or both. Consequently the pipeline industry recognizes a need for increased awareness of methods for identifying and evaluating landslide and subsidence hazard for pipeline corridors. This report was prepared in cooperation with the U.S. Department of Transportation Pipeline and Hazardous Materials Safety Administration, and Pipeline Research Council International through a cooperative research and development agreement (CRADA) with DGH Consulting, Inc., to address the need for up-to-date information about current methods to identify and assess these hazards. Chapters in this report (1) describe methods for evaluating landslide hazard on a regional basis, (2) describe the various types of land subsidence hazard in the United States and available methods for identifying and quantifying subsidence, and (3) summarize current methods for investigating individual landslides. In addition to the descriptions, this report provides information about the relative costs, limitations and reliability of various methods.

Landscape scale ecological monitoring as part of an EIA of major construction activities: experience at the Turkish section of the BTC crude oil pipeline project.

PubMed

Sahin, Sükran; Kurum, Ekrem

2009-09-01

Ecological monitoring is a complementary component of the overall environmental management and monitoring program of any Environmental Impact Assessment (EIA) report. The monitoring method should be developed for each project phase and allow for periodic reporting and assessment of compliance with the environmental conditions and requirements of the EIA. Also, this method should incorporate a variance request program since site-specific conditions can affect construction on a daily basis and require time-critical application of alternative construction scenarios or environmental management methods integrated with alternative mitigation measures. Finally, taking full advantage of the latest information and communication technologies can enhance the quality of, and public involvement in, the environmental management program. In this paper, a landscape-scale ecological monitoring method for major construction projects is described using, as a basis, 20 months of experience on the Baku-Tbilisi-Ceyhan (BTC) Crude Oil Pipeline Project, covering Turkish Sections Lot B and Lot C. This analysis presents suggestions for improving ecological monitoring for major construction activities.

F-16XL Ship #2 during last flight viewed from tanker showing titanium laminar flow glove on left win

NASA Technical Reports Server (NTRS)

1996-01-01

Dryden research pilot Dana Purifoy drops NASA F-16XL #848 away from the tanker in the 44th flight in the Supersonic Laminar Flow Control program recently. The flight test portion of the program ended with the 45th and last data collection flight Nov. 26, 1996. The project demonstrated that laminar--or smooth--airflow could be achieved over a major portion of a wing at supersonic speeds by use of a suction system. The system drew turbulent boundary-layer air through millions of tiny laser-drilled holes in a titanium 'glove' fitted to the upper left wing. About 90 hours of flight time were logged by the unique aircraft during the 13-month flight research program, much of it at speeds of Mach 2. Data acquired during the program will be used to develop a design code calibration database which could assist designers in reducing aerodynamic drag of a proposed second-generation supersonic transport.

Molgenis-impute: imputation pipeline in a box.

PubMed

Kanterakis, Alexandros; Deelen, Patrick; van Dijk, Freerk; Byelas, Heorhiy; Dijkstra, Martijn; Swertz, Morris A

2015-08-19

Genotype imputation is an important procedure in current genomic analysis such as genome-wide association studies, meta-analyses and fine mapping. Although high quality tools are available that perform the steps of this process, considerable effort and expertise is required to set up and run a best practice imputation pipeline, particularly for larger genotype datasets, where imputation has to scale out in parallel on computer clusters. Here we present MOLGENIS-impute, an 'imputation in a box' solution that seamlessly and transparently automates the set up and running of all the steps of the imputation process. These steps include genome build liftover (liftovering), genotype phasing with SHAPEIT2, quality control, sample and chromosomal chunking/merging, and imputation with IMPUTE2. MOLGENIS-impute builds on MOLGENIS-compute, a simple pipeline management platform for submission and monitoring of bioinformatics tasks in High Performance Computing (HPC) environments like local/cloud servers, clusters and grids. All the required tools, data and scripts are downloaded and installed in a single step. Researchers with diverse backgrounds and expertise have tested MOLGENIS-impute on different locations and imputed over 30,000 samples so far using the 1,000 Genomes Project and new Genome of the Netherlands data as the imputation reference. The tests have been performed on PBS/SGE clusters, cloud VMs and in a grid HPC environment. MOLGENIS-impute gives priority to the ease of setting up, configuring and running an imputation. It has minimal dependencies and wraps the pipeline in a simple command line interface, without sacrificing flexibility to adapt or limiting the options of underlying imputation tools. It does not require knowledge of a workflow system or programming, and is targeted at researchers who just want to apply best practices in imputation via simple commands. It is built on the MOLGENIS compute workflow framework to enable customization with additional

75 FR 52938 - ANR Pipeline Company; Notice of Request Under Blanket Authorization

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-30

... proposes to abandon by sale approximately its Line 607 \\2\\ (4.41 miles of 16-inch diameter pipeline) and... (1999). Any questions concerning this application may be directed to Rene Staeb, Manager, Project... telephone at (832) 320-5215, facsimile (832) 320-6215, or e-mail rene[email protected] . This filing is...

49 CFR 192.755 - Protecting cast-iron pipelines.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 3 2012-10-01 2012-10-01 false Protecting cast-iron pipelines. 192.755 Section... NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Maintenance § 192.755 Protecting cast... pipeline is disturbed: (a) That segment of the pipeline must be protected, as necessary, against damage...

49 CFR 192.755 - Protecting cast-iron pipelines.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false Protecting cast-iron pipelines. 192.755 Section... NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Maintenance § 192.755 Protecting cast... pipeline is disturbed: (a) That segment of the pipeline must be protected, as necessary, against damage...

49 CFR 192.755 - Protecting cast-iron pipelines.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 3 2014-10-01 2014-10-01 false Protecting cast-iron pipelines. 192.755 Section... NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Maintenance § 192.755 Protecting cast... pipeline is disturbed: (a) That segment of the pipeline must be protected, as necessary, against damage...

49 CFR 192.755 - Protecting cast-iron pipelines.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Protecting cast-iron pipelines. 192.755 Section... NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Maintenance § 192.755 Protecting cast... pipeline is disturbed: (a) That segment of the pipeline must be protected, as necessary, against damage...

30 CFR 250.1005 - Inspection requirements for DOI pipelines.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false Inspection requirements for DOI pipelines. 250.1005 Section 250.1005 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT... Pipelines and Pipeline Rights-of-Way § 250.1005 Inspection requirements for DOI pipelines. (a) Pipeline...

78 FR 49749 - Williams Olefins Feedstock Pipelines, L.L.C.; Notice of Petition for Declaratory Order

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-15

... order finding that a proposed Bayou Ethane Pipeline project is not subject to Commission's jurisdiction because the transported ethane will only be used as feedstock to produce ethylene, and not burned as fuel...

Spin-tunnel investigation of a 1/25-scale model of the General Dynamics F-16XL airplane

NASA Technical Reports Server (NTRS)

Whipple, R. D.; White, W. L.

1984-01-01

A spin-tunnel investigation of the spin and recovery characteristics of a 1/25-scale model to the General Dynamics F-16XL aircraft was conducted in the Langley Spin Tunnel. Tests included erect and inverted spins at various symmetric and asymmetric loading conditions. The required size of an emergency spin-recovery parachute was determined.

Quercetin Potentiates Doxorubicin Mediated Antitumor Effects against Liver Cancer through p53/Bcl-xl

PubMed Central

Wang, Guanyu; Sharma, Sherven; Dong, Qinghua

2012-01-01

Background The dose-dependent toxicities of doxorubicin (DOX) limit its clinical applications, particularly in drug-resistant cancers, such as liver cancer. In this study, we investigated the role of quercetin on the antitumor effects of DOX on liver cancer cells and its ability to provide protection against DOX-mediated liver damage in mice. Methodology and Results The MTT and Annexin V/PI staining assay demonstrated that quercetin selectively sensitized DOX-induced cytotoxicity against liver cancer cells while protecting normal liver cells. The increase in DOX-mediated apoptosis in hepatoma cells by quercetin was p53-dependent and occurred by downregulating Bcl-xl expression. Z-VAD-fmk (caspase inhibitor), pifithrin-α (p53 inhibitor), or overexpressed Bcl-xl decreased the effects of quercetin on DOX-mediated apoptosis. The combined treatment of quercetin and DOX significantly reduced the growth of liver cancer xenografts in mice. Moreover, quercetin decreased the serum levels of alanine aminotransferase and aspartate aminotransferase that were increased in DOX-treated mice. Quercetin also reversed the DOX-induced pathological changes in mice livers. Conclusion and Significance These results indicate that quercetin potentiated the antitumor effects of DOX on liver cancer cells while protecting normal liver cells. Therefore, the development of quercetin may be beneficial in a combined treatment with DOX for increased therapeutic efficacy against liver cancer. PMID:23240061

49 CFR 192.627 - Tapping pipelines under pressure.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 3 2010-10-01 2010-10-01 false Tapping pipelines under pressure. 192.627 Section... NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Operations § 192.627 Tapping pipelines under pressure. Each tap made on a pipeline under pressure must be performed by a crew qualified to make...

Stability of subsea pipelines during large storms

PubMed Central

Draper, Scott; An, Hongwei; Cheng, Liang; White, David J.; Griffiths, Terry

2015-01-01

On-bottom stability design of subsea pipelines transporting hydrocarbons is important to ensure safety and reliability but is challenging to achieve in the onerous metocean (meteorological and oceanographic) conditions typical of large storms (such as tropical cyclones, hurricanes or typhoons). This challenge is increased by the fact that industry design guidelines presently give no guidance on how to incorporate the potential benefits of seabed mobility, which can lead to lowering and self-burial of the pipeline on a sandy seabed. In this paper, we demonstrate recent advances in experimental modelling of pipeline scour and present results investigating how pipeline stability can change in a large storm. An emphasis is placed on the initial development of the storm, where scour is inevitable on an erodible bed as the storm velocities build up to peak conditions. During this initial development, we compare the rate at which peak near-bed velocities increase in a large storm (typically less than 10−3 m s−2) to the rate at which a pipeline scours and subsequently lowers (which is dependent not only on the storm velocities, but also on the mechanism of lowering and the pipeline properties). We show that the relative magnitude of these rates influences pipeline embedment during a storm and the stability of the pipeline. PMID:25512592

Upper quadrant port placement for robot-assisted renal surgery: implementation of the Floating Arm and the XL Protype.

PubMed

Totonchi, Samer; Elgin, Robert; Monahan, Michael; Johnston, William K

2014-08-01

Abstract Background and Purpose: Placement of the fourth arm (4th arm) in the lower quadrant (LQ) is commonly described for robot-assisted renal surgical procedures but has anatomic restrictions and limited ergonomics. An alternative, upper quadrant (UQ) location is desirable, but patient habitus and spacing may restrict robotic attachment. We investigate current trends in 4th arm port placement and propose an alternative method at attaching the robot-the "Floating Arm" (FLA). Robotic surgeons from the Endourological Society were surveyed. A 20-cm extra-long (XL Protype) da Vinci instrument was developed for the FLA technique. A dry lab allowed quantitative comparison of spacing and ranges of motion for standard da Vinci ports (dVP), bariatric dVP, telescoping dVP, and FLA. There were 108 respondents who participated. Half of the respondents avoid using the 4th arm (30% lack of need and 20% because of interference). The majority (90%) typically positions the 4th arm in the LQ, but many reported limitations in this location. Few (5%) place 4th arm in the UQ, while most (73%) have never heard of UQ placement. Existing techniques may increase shoulder height clearance but inversely shorten the working length of the instrument intracorporeally. Alternatively, the XL Protype significantly increased the shoulder length and maintained available working distances intracorporeally. Adjacent arm interference angle was essentially identical (27 degrees) for all ports except a greater range of movement for the XL Protype (35 degrees). Few surgeons are using an UQ positioning or use techniques to improve attachment of the 4th arm. The greatest freedom may be obtained by implementing the FLA, but this necessitates production of a longer instrument.

PRIMO: An Interactive Homology Modeling Pipeline.

PubMed

Hatherley, Rowan; Brown, David K; Glenister, Michael; Tastan Bishop, Özlem

2016-01-01

The development of automated servers to predict the three-dimensional structure of proteins has seen much progress over the years. These servers make calculations simpler, but largely exclude users from the process. In this study, we present the PRotein Interactive MOdeling (PRIMO) pipeline for homology modeling of protein monomers. The pipeline eases the multi-step modeling process, and reduces the workload required by the user, while still allowing engagement from the user during every step. Default parameters are given for each step, which can either be modified or supplemented with additional external input. PRIMO has been designed for users of varying levels of experience with homology modeling. The pipeline incorporates a user-friendly interface that makes it easy to alter parameters used during modeling. During each stage of the modeling process, the site provides suggestions for novice users to improve the quality of their models. PRIMO provides functionality that allows users to also model ligands and ions in complex with their protein targets. Herein, we assess the accuracy of the fully automated capabilities of the server, including a comparative analysis of the available alignment programs, as well as of the refinement levels used during modeling. The tests presented here demonstrate the reliability of the PRIMO server when producing a large number of protein models. While PRIMO does focus on user involvement in the homology modeling process, the results indicate that in the presence of suitable templates, good quality models can be produced even without user intervention. This gives an idea of the base level accuracy of PRIMO, which users can improve upon by adjusting parameters in their modeling runs. The accuracy of PRIMO's automated scripts is being continuously evaluated by the CAMEO (Continuous Automated Model EvaluatiOn) project. The PRIMO site is free for non-commercial use and can be accessed at https://primo.rubi.ru.ac.za/.

PRIMO: An Interactive Homology Modeling Pipeline

PubMed Central

Glenister, Michael

2016-01-01

The development of automated servers to predict the three-dimensional structure of proteins has seen much progress over the years. These servers make calculations simpler, but largely exclude users from the process. In this study, we present the PRotein Interactive MOdeling (PRIMO) pipeline for homology modeling of protein monomers. The pipeline eases the multi-step modeling process, and reduces the workload required by the user, while still allowing engagement from the user during every step. Default parameters are given for each step, which can either be modified or supplemented with additional external input. PRIMO has been designed for users of varying levels of experience with homology modeling. The pipeline incorporates a user-friendly interface that makes it easy to alter parameters used during modeling. During each stage of the modeling process, the site provides suggestions for novice users to improve the quality of their models. PRIMO provides functionality that allows users to also model ligands and ions in complex with their protein targets. Herein, we assess the accuracy of the fully automated capabilities of the server, including a comparative analysis of the available alignment programs, as well as of the refinement levels used during modeling. The tests presented here demonstrate the reliability of the PRIMO server when producing a large number of protein models. While PRIMO does focus on user involvement in the homology modeling process, the results indicate that in the presence of suitable templates, good quality models can be produced even without user intervention. This gives an idea of the base level accuracy of PRIMO, which users can improve upon by adjusting parameters in their modeling runs. The accuracy of PRIMO’s automated scripts is being continuously evaluated by the CAMEO (Continuous Automated Model EvaluatiOn) project. The PRIMO site is free for non-commercial use and can be accessed at https://primo.rubi.ru.ac.za/. PMID:27855192

Biomechanically Induced and Controller Coupled Oscillations Experienced on the F-16XL Aircraft During Rolling Maneuvers

NASA Technical Reports Server (NTRS)

Smith, John W.; Montgomery, Terry

1996-01-01

During rapid rolling maneuvers, the F-16 XL aircraft exhibits a 2.5 Hz lightly damped roll oscillation, perceived and described as 'roll ratcheting.' This phenomenon is common with fly-by-wire control systems, particularly when primary control is derived through a pedestal-mounted side-arm controller. Analytical studies have been conducted to model the nature of the integrated control characteristics. The analytical results complement the flight observations. A three-degree-of-freedom linearized set of aerodynamic matrices was assembled to simulate the aircraft plant. The lateral-directional control system was modeled as a linear system. A combination of two second-order transfer functions was derived to couple the lateral acceleration feed through effect of the operator's arm and controller to the roll stick force input. From the combined systems, open-loop frequency responses and a time history were derived, describing and predicting an analogous in-flight situation. This report describes the primary control, aircraft angular rate, and position time responses of the F-16 XL-2 aircraft during subsonic and high-dynamic-pressure rolling maneuvers. The analytical description of the pilot's arm and controller can be applied to other aircraft or simulations to assess roll ratcheting susceptibility.

Pipeline transport and simultaneous saccharification of corn stover.

PubMed

Kumar, Amit; Cameron, Jay B; Flynn, Peter C

2005-05-01

Pipeline transport of corn stover delivered by truck from the field is evaluated against a range of truck transport costs. Corn stover transported by pipeline at 20% solids concentration (wet basis) or higher could directly enter an ethanol fermentation plant, and hence the investment in the pipeline inlet end processing facilities displaces comparable investment in the plant. At 20% solids, pipeline transport of corn stover costs less than trucking at capacities in excess of 1.4 M drytonnes/yr when compared to a mid range of truck transport cost (excluding any credit for economies of scale achieved in the ethanol fermentation plant from larger scale due to multiple pipelines). Pipelining of corn stover gives the opportunity to conduct simultaneous transport and saccharification (STS). If current enzymes are used, this would require elevated temperature. Heating of the slurry for STS, which in a fermentation plant is achieved from waste heat, is a significant cost element (more than 5 cents/l of ethanol) if done at the pipeline inlet unless waste heat is available, for example from an electric power plant located adjacent to the pipeline inlet. Heat loss in a 1.26 m pipeline carrying 2 M drytonnes/yr is about 5 degrees C at a distance of 400 km in typical prairie clay soils, and would not likely require insulation; smaller pipelines or different soil conditions might require insulation for STS. Saccharification in the pipeline would reduce the need for investment in the fermentation plant, saving about 0.2 cents/l of ethanol. Transport of corn stover in multiple pipelines offers the opportunity to develop a large ethanol fermentation plant, avoiding some of the diseconomies of scale that arise from smaller plants whose capacities are limited by issues of truck congestion.

California crude-pipeline plans detailed

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ronco, M.J.

1986-06-09

California and the U.S. West have recently become a center for crude-oil pipeline activity. That activity includes existing and proposed lines, offshore and onshore terminals, and some unusual permitting and construction requirements. Operation of existing pipelines is influenced by the varying gravities of crudes in the area. California has three distinct producing areas from which pipelines deliver crude to refineries or marines terminals: 1. The inland Los Angeles basin and coast from Orange County to Ventura County. 2. The San Joaquin Valley in central California which is between the coastal mountains and the Sierras. 3. That portion of the Outermore » Continental Shelf (OCS) located primarily in federal waters off Santa Barbara and San Luis Obispo counties on the central coast. The Los Angeles coastal and inland basin crude-oil pipeline system consists of gathering lines to move crude from the many wells throughout Ventura, Orange, and Los Angeles counties to operating refineries in the greater Los Angeles area. Major refineries include ARCO at Carson, Chevron at El Segundo, Mobil at Torrance, and Shell, Texaco, and Unical at Wilmington. The many different crude-oil pipelines serving these refineries from Ventura County and Orange County and from the many sites around Los Angeles County are too numerous to list.« less

Understanding Underrepresented Populations in the Business School Pipeline. GMAC® Research Report RR-16-02

ERIC Educational Resources Information Center

Daniel, Rhonda; Caruthers, Devina

2016-01-01

This white paper, "Understanding Underrepresented Populations in the Business School Pipeline," examines the shifting US racial and ethnic demographics and projected growth among US minority populations and the challenges--and incentives--these developments pose for US business schools to increase the opportunities for minority students…

The Challenge of Creating a More Diverse Economics: Lessons from the UCR Minority Pipeline Project

ERIC Educational Resources Information Center

Dymski, Gary A.

2017-01-01

This paper reflects on the experience of the 1999-2002 minority pipeline program (MPP) at the University of California, Riverside. With support from the American Economic Association, the MPP identified students of color interested in economics, let them explore economic issues affecting minority communities, and encouraged them to consider…

Immersion probe arrays for rapid pipeline weld inspection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lebsack, S.; Heckhauser, H.

In 1992, F.H. Gottfeld, Herne, Germany, a member of the SGA Group (Societe Generale de Surveillance) and Krautkramer Branson, Koin, undertook production of a rapid automated ultrasonic testing (UT) system to inspect manually and machine welded pipeline girth welds. The result of the project is a system called MIPA, or multiple immersion probe array. The advantages of using UT to detect certain weld defects have been realized for many years, however for some applications the time required for UT has been a limiting factor. Where time has not been a factor, automated ultrasonic technology has advanced a reliable solution tomore » many inspection problems across a broad industrial base. The recent past has seen the entrance of automated ultrasonic technology into the harsh and demanding environment of pipelay operations, However, the use of these systems has been focused on automated welding processes. Their effectiveness for manual pipeline welding inspection is contested. This is due to the infinite variability of the joint alignment and shape that is unavoidable even when highly skilled welders are used.« less

Redefining the Data Pipeline Using GPUs

NASA Astrophysics Data System (ADS)

Warner, C.; Eikenberry, S. S.; Gonzalez, A. H.; Packham, C.

2013-10-01

There are two major challenges facing the next generation of data processing pipelines: 1) handling an ever increasing volume of data as array sizes continue to increase and 2) the desire to process data in near real-time to maximize observing efficiency by providing rapid feedback on data quality. Combining the power of modern graphics processing units (GPUs), relational database management systems (RDBMSs), and extensible markup language (XML) to re-imagine traditional data pipelines will allow us to meet these challenges. Modern GPUs contain hundreds of processing cores, each of which can process hundreds of threads concurrently. Technologies such as Nvidia's Compute Unified Device Architecture (CUDA) platform and the PyCUDA (http://mathema.tician.de/software/pycuda) module for Python allow us to write parallel algorithms and easily link GPU-optimized code into existing data pipeline frameworks. This approach has produced speed gains of over a factor of 100 compared to CPU implementations for individual algorithms and overall pipeline speed gains of a factor of 10-25 compared to traditionally built data pipelines for both imaging and spectroscopy (Warner et al., 2011). However, there are still many bottlenecks inherent in the design of traditional data pipelines. For instance, file input/output of intermediate steps is now a significant portion of the overall processing time. In addition, most traditional pipelines are not designed to be able to process data on-the-fly in real time. We present a model for a next-generation data pipeline that has the flexibility to process data in near real-time at the observatory as well as to automatically process huge archives of past data by using a simple XML configuration file. XML is ideal for describing both the dataset and the processes that will be applied to the data. Meta-data for the datasets would be stored using an RDBMS (such as mysql or PostgreSQL) which

A Microsoft-Excel-based tool for running and critically appraising network meta-analyses—an overview and application of NetMetaXL

PubMed Central

2014-01-01

Background The use of network meta-analysis has increased dramatically in recent years. WinBUGS, a freely available Bayesian software package, has been the most widely used software package to conduct network meta-analyses. However, the learning curve for WinBUGS can be daunting, especially for new users. Furthermore, critical appraisal of network meta-analyses conducted in WinBUGS can be challenging given its limited data manipulation capabilities and the fact that generation of graphical output from network meta-analyses often relies on different software packages than the analyses themselves. Methods We developed a freely available Microsoft-Excel-based tool called NetMetaXL, programmed in Visual Basic for Applications, which provides an interface for conducting a Bayesian network meta-analysis using WinBUGS from within Microsoft Excel. . This tool allows the user to easily prepare and enter data, set model assumptions, and run the network meta-analysis, with results being automatically displayed in an Excel spreadsheet. It also contains macros that use NetMetaXL’s interface to generate evidence network diagrams, forest plots, league tables of pairwise comparisons, probability plots (rankograms), and inconsistency plots within Microsoft Excel. All figures generated are publication quality, thereby increasing the efficiency of knowledge transfer and manuscript preparation. Results We demonstrate the application of NetMetaXL using data from a network meta-analysis published previously which compares combined resynchronization and implantable defibrillator therapy in left ventricular dysfunction. We replicate results from the previous publication while demonstrating result summaries generated by the software. Conclusions Use of the freely available NetMetaXL successfully demonstrated its ability to make running network meta-analyses more accessible to novice WinBUGS users by allowing analyses to be conducted entirely within Microsoft Excel. NetMetaXL also allows

Overview of the Cranked-Arrow Wing Aerodynamics Project International

NASA Technical Reports Server (NTRS)

Obara, Clifford J.; Lamar, John E.

2008-01-01

This paper provides a brief history of the F-16XL-1 aircraft, its role in the High Speed Research program and how it was morphed into the Cranked Arrow Wing Aerodynamics Project. Various flight, wind-tunnel and Computational Fluid Dynamics data sets were generated as part of the project. These unique and open flight datasets for surface pressures, boundary-layer profiles and skin-friction distributions, along with surface flow data, are described and sample data comparisons given. This is followed by a description of how the project became internationalized to be known as Cranked Arrow Wing Aerodynamics Project International and is concluded by an introduction to the results of a four year computational predictive study of data collected at flight conditions by participating researchers.

Nearshore Pipeline Installation Methods.

DTIC Science & Technology

1981-08-01

inches b) Pipe, materials of construction: fully rigid, semi-rigid, flexible c) Pipeline length, maximum 2 miles d) Pipeline design life , minimum 15...common to their operations. Permanent facilities are specified in the Statement of Work. There- fore, a minimum design life of 15 years is chosen, which...makes the pipe leakproof and resists corrosion and abrasion. 5) Interlocked Z-shaped steel or stainless steel carcass - resists internal and external

Analysis pipelines and packages for Infinium HumanMethylation450 BeadChip (450k) data.

PubMed

Morris, Tiffany J; Beck, Stephan

2015-01-15

The Illumina HumanMethylation450 BeadChip has become a popular platform for interrogating DNA methylation in epigenome-wide association studies (EWAS) and related projects as well as resource efforts such as the International Cancer Genome Consortium (ICGC) and the International Human Epigenome Consortium (IHEC). This has resulted in an exponential increase of 450k data in recent years and triggered the development of numerous integrated analysis pipelines and stand-alone packages. This review will introduce and discuss the currently most popular pipelines and packages and is particularly aimed at new 450k users. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

78 FR 52820 - Pipeline Safety: Request for Special Permit

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-26

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2013-0181] Pipeline Safety: Request for Special Permit AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA); DOT. ACTION: Notice. SUMMARY: Pursuant to the Federal pipeline safety laws...

78 FR 52821 - Pipeline Safety: Request for Special Permit

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-26

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2013-0146] Pipeline Safety: Request for Special Permit AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA); DOT. ACTION: Notice. SUMMARY: Pursuant to the Federal pipeline safety laws...

78 FR 5866 - Pipeline Safety: Annual Reports and Validation

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-28

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket ID PHMSA-2012-0319] Pipeline Safety: Annual Reports and Validation AGENCY: Pipeline and Hazardous Materials... 2012 gas transmission and gathering annual reports, remind pipeline owners and operators to validate...

75 FR 77000 - South Coast Conduit/Upper Reach Reliability Project, Santa Barbara County, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-10

... pipeline for improving water supply reliability to Cachuma Project (CP) and State Water Project (SWP... percent of the water supply for communities along the South Coast of Santa Barbara County. Reclamation... demands it is not able to provide the water needed. No redundant supply or pipeline exists to convey CVP...

75 FR 43612 - Pipeline Safety: Request for Special Permit

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-26

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2010-0042] Pipeline Safety: Request for Special Permit AGENCY: Pipeline and Hazardous Materials..., Inc., a natural gas pipeline operator, seeking relief from compliance with certain requirements in the...

77 FR 34458 - Pipeline Safety: Requests for Special Permit

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-11

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2012-0112] Pipeline Safety: Requests for Special Permit AGENCY: Pipeline and Hazardous Materials... BreitBurn Energy Company LP, two natural gas pipeline operators, seeking relief from compliance with...

75 FR 66425 - Pipeline Safety: Request for Special Permit

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-28

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2010-0124] Pipeline Safety: Request for Special Permit AGENCY: Pipeline and Hazardous Materials... Company, LP, a natural gas pipeline operator, seeking relief from compliance with certain requirements in...

78 FR 14877 - Pipeline Safety: Incident and Accident Reports

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-07

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket ID PHMSA-2013-0028] Pipeline Safety: Incident and Accident Reports AGENCY: Pipeline and Hazardous Materials... PHMSA F 7100.2--Incident Report--Natural and Other Gas Transmission and Gathering Pipeline Systems and...

75 FR 9018 - Pipeline Safety: Random Drug Testing Rate

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-26

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket ID PHMSA-2010-0034] Pipeline Safety: Random Drug Testing Rate AGENCY: Pipeline and Hazardous Materials... pipelines and operators of liquefied natural gas facilities must select and test a percentage of covered...

77 FR 2606 - Pipeline Safety: Random Drug Testing Rate

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-18

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket ID PHMSA-2012-0004] Pipeline Safety: Random Drug Testing Rate AGENCY: Pipeline and Hazardous Materials... pipelines and operators of liquefied natural gas facilities must select and test a percentage of covered...

Regulatory reform for natural gas pipelines: The effect on pipeline and distribution company share prices

NASA Astrophysics Data System (ADS)

Jurman, Elisabeth Antonie

1997-08-01

The natural gas shortages in the 1970s focused considerable attention on the federal government's role in altering energy consumption. For the natural gas industry these shortages eventually led to the passage of the Natural Gas Policy Act (NGPA) in 1978 as part of the National Energy Plan. A series of events in the decade of the 1980s has brought about the restructuring of interstate natural gas pipelines which have been transformed by regulators and the courts from monopolies into competitive entities. This transformation also changed their relationship with their downstream customers, the LDCs, who no longer had to deal with pipelines as the only merchants of gas. Regulatory reform made it possible for LDCs to buy directly from producers using the pipelines only for delivery of their purchases. This study tests for the existence of monopoly rents by analyzing the daily returns of natural gas pipeline and utility industry stock price data from 1982 to 1990, a period of regulatory reform for the natural gas industry. The study's main objective is to investigate the degree of empirical support for claims that regulatory reforms increase profits in the affected industry, as the normative theory of regulation expects, or decrease profits, as advocates of the positive theory of regulation believe. I also test Norton's theory of risk which predicts that systematic risk will increase for firms undergoing deregulation. Based on a sample of twelve natural gas pipelines, and 25 utilities an event study concept was employed to measure the impact of regulatory event announcements on daily natural gas pipeline or utility industry stock price data using a market model regression equation. The results of this study provide some evidence that regulatory reforms did not increase the profits of pipeline firms, confirming the expectations of those who claim that excess profits result from regulation and will disappear, once that protection is removed and the firms are operating in

Evidence and root causes of an inadequate pipeline for nursing faculty.

PubMed

Cleary, Brenda; Bevill, James W; Lacey, Linda M; Nooney, Jennifer G

2007-01-01

The North Carolina Center for Nursing (NCCN) examined the projected supply of nursing faculty in the state of North Carolina. Coupled with a longitudinal educational mobility study of the state's registered nurses, the forecast shows that the growing faculty shortage is real and that its root cause is a growing shortfall in the pipeline of RNs prepared educationally to pursue graduate education and assume faculty roles.

75 FR 2126 - Calais Pipeline Company, LLC; Calais LNG Project Company, LLC; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-14

... 7(c) of the Natural Gas Act (NGA), respectively, as amended and Parts 153, 157, 284 and 380 of the Commission's regulations requesting: (1) Authorization to site, construct and operate a new liquefied natural... approximately 20.7 miles of 36-inch-diameter pipeline and related facilities in order to transport natural gas...

78 FR 65429 - Pipeline Safety: Request for Special Permit

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-31

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2010-0041] Pipeline Safety: Request for Special Permit AGENCY: Pipeline and Hazardous Materials...-0041 Williams Gas Pipeline 49 CFR 192.150........ To authorize the extension Company, LLC (WGP). of a...

76 FR 11853 - Pipeline Safety: Request for Special Permit

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-03

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2011-0027] Pipeline Safety: Request for Special Permit AGENCY: Pipeline and Hazardous Materials... a 24-inch mainline natural gas pipeline, 595 feet in length. The first segment of the special permit...

Lessons Learned from Developing and Operating the Kepler Science Pipeline and Building the TESS Science Pipeline

NASA Technical Reports Server (NTRS)

Jenkins, Jon M.

2017-01-01

The experience acquired through development, implementation and operation of the KeplerK2 science pipelines can provide lessons learned for the development of science pipelines for other missions such as NASA's Transiting Exoplanet Survey Satellite, and ESA's PLATO mission.

75 FR 40863 - Pipeline Safety: Information Collection Activities

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-14

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2010-0193] Pipeline Safety: Information Collection Activities AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice and request for comments. SUMMARY: In...

77 FR 74276 - Pipeline Safety: Information Collection Activities

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-13

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2012-0302] Pipeline Safety: Information Collection Activities AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice and request for comments. SUMMARY: In...

76 FR 50539 - Pipeline Safety: Information Collection Activities

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-15

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2011-0136] Pipeline Safety: Information Collection Activities AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice and request for comments. SUMMARY: In...

75 FR 35516 - Pipeline Safety: Request for Special Permit

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-22

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2010-0147] Pipeline Safety: Request for Special Permit AGENCY: Pipeline and Hazardous Materials... with the Class 1 location portion of a 7.4 mile natural gas pipeline to be constructed in Alaska. This...

49 CFR 192.513 - Test requirements for plastic pipelines.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false Test requirements for plastic pipelines. 192.513 Section 192.513 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND... Test requirements for plastic pipelines. (a) Each segment of a plastic pipeline must be tested in...

49 CFR 192.513 - Test requirements for plastic pipelines.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 3 2010-10-01 2010-10-01 false Test requirements for plastic pipelines. 192.513 Section 192.513 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND... Test requirements for plastic pipelines. (a) Each segment of a plastic pipeline must be tested in...

49 CFR 192.513 - Test requirements for plastic pipelines.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Test requirements for plastic pipelines. 192.513 Section 192.513 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND... Test requirements for plastic pipelines. (a) Each segment of a plastic pipeline must be tested in...

49 CFR 192.513 - Test requirements for plastic pipelines.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 3 2014-10-01 2014-10-01 false Test requirements for plastic pipelines. 192.513 Section 192.513 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND... Test requirements for plastic pipelines. (a) Each segment of a plastic pipeline must be tested in...

49 CFR 192.513 - Test requirements for plastic pipelines.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 3 2012-10-01 2012-10-01 false Test requirements for plastic pipelines. 192.513 Section 192.513 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND... Test requirements for plastic pipelines. (a) Each segment of a plastic pipeline must be tested in...

78 FR 16764 - Pipeline Safety: Information Collection Activities

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-18

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2012-0302] Pipeline Safety: Information Collection Activities AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice and Request for Comments on a Previously...

76 FR 70217 - Pipeline Safety: Information Collection Activities

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-10

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Administration [Docket No. PHMSA... OMB approval of new Information Collection. AGENCY: Pipeline and Hazardous Materials Safety... Pipeline and Hazardous Materials Safety Administration (PHMSA) published a notice in the Federal Register...

Low-Speed Aerodynamic Data for an 0.18-Scale Model of an F-16XL with Various Leading-Edge Modifications

NASA Technical Reports Server (NTRS)

Hahne, Daniel E.

1999-01-01

Using the F-16XL as a test-bed, two strategies for improving the low-speed flying characteristics that had minimal impact on high-speed performance were evaluated. In addition to the basic F-16XL configuration several modifications to the baseline configuration were tested in the Langley 30- X 60-Foot Tunnel: 1) the notched area at the wing leading edge and fuselage juncture was removed resulting in a continuous 70 deg leading-edge sweep on the inboard portion of the wing; 2) an integral attached-flow leading-edge flap concept was added to the continuous leading edge; and 3) a deployable vortex flap concept was added to the continuous leading edge. The purpose of this report is simply to document the test configurations, test conditions, and data obtained in this investigation for future reference and analysis. No analysis is presented herein and the data only appear in tabulated format.