26 CFR 1.381(c)(1)-1 - Net operating loss carryovers in certain corporate acquisitions.

Code of Federal Regulations, 2014 CFR

2014-04-01

...) 1956 ($35,000) ($5,000) Ending 12-16-57 (30,000) xxx 1957 xxx 36,500 (ii) The aggregate of the net... Corporation (acquirer) 1954 ($5,000) xxx 1955 (15,000) xxx 1956 (10,000) $20,000 1957 xxx 40,000 (ii) The...-56 (1,000) (9,000) xxx 1956 xxx xxx 73,200 (ii) The aggregate of the net operating loss carryovers of...

26 CFR 1.381(c)(1)-1 - Net operating loss carryovers in certain corporate acquisitions.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) 1956 ($35,000) ($5,000) Ending 12-16-57 (30,000) xxx 1957 xxx 36,500 (ii) The aggregate of the net... Corporation (acquirer) 1954 ($5,000) xxx 1955 (15,000) xxx 1956 (10,000) $20,000 1957 xxx 40,000 (ii) The...-56 (1,000) (9,000) xxx 1956 xxx xxx 73,200 (ii) The aggregate of the net operating loss carryovers of...

26 CFR 1.381(c)(1)-1 - Net operating loss carryovers in certain corporate acquisitions.

Code of Federal Regulations, 2012 CFR

2012-04-01

...) 1956 ($35,000) ($5,000) Ending 12-16-57 (30,000) xxx 1957 xxx 36,500 (ii) The aggregate of the net... Corporation (acquirer) 1954 ($5,000) xxx 1955 (15,000) xxx 1956 (10,000) $20,000 1957 xxx 40,000 (ii) The...-56 (1,000) (9,000) xxx 1956 xxx xxx 73,200 (ii) The aggregate of the net operating loss carryovers of...

26 CFR 1.381(c)(1)-1 - Net operating loss carryovers in certain corporate acquisitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

...) 1956 ($35,000) ($5,000) Ending 12-16-57 (30,000) xxx 1957 xxx 36,500 (ii) The aggregate of the net... Corporation (acquirer) 1954 ($5,000) xxx 1955 (15,000) xxx 1956 (10,000) $20,000 1957 xxx 40,000 (ii) The...-56 (1,000) (9,000) xxx 1956 xxx xxx 73,200 (ii) The aggregate of the net operating loss carryovers of...

Registration of Seven Sugarbeet Germplasms Selected from Crosses between Cultivated Sugarbeet and Wild Beta Species

USDA-ARS?s Scientific Manuscript database

Seven sugarbeet (Beta vulgaris L.) germplasm lines, F1017 (GP-xxx, PIxxxxxx), F1018 (GP-xxx, PIxxxxxx), F1019 (GP-xxx, PIxxxxxx), F1020 (GP-xxx, PIxxxxxx), F1021 (GP-xxx, PIxxxxxx), F1022 (GP-xxx, PIxxxxxx), and F1023 (GP-xxx, PIxxxxxx) were released 23 February 2009 by the USDA-ARS and the North Da...

77 FR 6694 - Notice of Proposed Policy Clarification for the Registration of Aircraft to U.S. Citizen Trustees...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-09

... Counsel, Federal Aviation Administration. TRUST AGREEMENT THIS TRUST AGREEMENT (XXX), dated as of XXX, (the ``Agreement'') by and between XXX, a [corporation organized and existing] [limited liability company formed] \\7\\ under the laws of XXX (``Trustor''), and XXX, a XXX organized and existing under the...

46 CFR Appendix A to Part 535 - Information Form and Instructions

Code of Federal Regulations, 2011 CFR

2011-10-01

... units] (B)Utilization [percent] Carrier A [Name] Liner Service 1 [Name] XX,XXX XX Liner Service 2 XX,XXX XX Liner Service 3 XX,XXX XX Etc. . . . Carrier B Liner Service 1 XX,XXX XX Liner Service 2 XX,XXX XX Liner Service 3 XX,XXX XX Etc. . . . Etc. . . . (C) Narrative statement on significant changes in vessel...

46 CFR Appendix A to Part 535 - Information Form and Instructions

Code of Federal Regulations, 2012 CFR

2012-10-01

... units] (B)Utilization [percent] Carrier A [Name] Liner Service 1 [Name] XX,XXX XX Liner Service 2 XX,XXX XX Liner Service 3 XX,XXX XX Etc. . . . Carrier B Liner Service 1 XX,XXX XX Liner Service 2 XX,XXX XX Liner Service 3 XX,XXX XX Etc. . . . Etc. . . . (C) Narrative statement on significant changes in vessel...

46 CFR Appendix A to Part 535 - Information Form and Instructions

Code of Federal Regulations, 2014 CFR

2014-10-01

... units] (B)Utilization [percent] Carrier A [Name] Liner Service 1 [Name] XX,XXX XX Liner Service 2 XX,XXX XX Liner Service 3 XX,XXX XX Etc. . . . Carrier B Liner Service 1 XX,XXX XX Liner Service 2 XX,XXX XX Liner Service 3 XX,XXX XX Etc. . . . Etc. . . . (C) Narrative statement on significant changes in vessel...

46 CFR Appendix A to Part 535 - Information Form and Instructions

Code of Federal Regulations, 2013 CFR

2013-10-01

... units] (B)Utilization [percent] Carrier A [Name] Liner Service 1 [Name] XX,XXX XX Liner Service 2 XX,XXX XX Liner Service 3 XX,XXX XX Etc. . . . Carrier B Liner Service 1 XX,XXX XX Liner Service 2 XX,XXX XX Liner Service 3 XX,XXX XX Etc. . . . Etc. . . . (C) Narrative statement on significant changes in vessel...

46 CFR Appendix A to Part 535 - Information Form and Instructions

Code of Federal Regulations, 2010 CFR

2010-10-01

... units] (B)Utilization [percent] Carrier A [Name] Liner Service 1 [Name] XX,XXX XX Liner Service 2 XX,XXX XX Liner Service 3 XX,XXX XX Etc. . . . Carrier B Liner Service 1 XX,XXX XX Liner Service 2 XX,XXX XX Liner Service 3 XX,XXX XX Etc. . . . Etc. . . . (C) Narrative statement on significant changes in vessel...

Conformational Change and Epimerization of Diketopiperazines Containing Proline Residue in Water.

PubMed

Ishizu, Takashi; Tsutsumi, Hiroyuki; Yokoyama, Emi; Kawamoto, Haruka; Yokota, Runa

2017-01-01

In water, diketopiperazines cyclo(L-Pro-L-Xxx) and cyclo(L-Pro-D-Xxx) (Xxx=Phe, Tyr) formed an intramolecular hydrophobic interaction between the main skeleton part and their benzene ring, and both cyclo(L-Pro-L-Xxx) and cyclo(L-Pro-D-Xxx) took a folded conformation. The conformational changes from folded to extended conformation by addition of several deuterated organic solvents (acetone-d 6 , metanol-d 4 , dimethyl sulfoxide-d 6 (DMSO-d 6 )) and the temperature rise were investigated using 1 H-NMR spectra. The results suggested that the intrarmolecular hydrophobic interaction of cyclo(L-Pro-D-Xxx) formed more strongtly than that of cyclo(L-Pro-L-Xxx). Under a basic condition of 1.0×10 -1  mol/L potassium deuteroxide, enolization of O 1 -C 1 -C 9 -H 9 moiety of cyclo(L-Pro-L-Xxx) occurred, while that of the O 4 -C 4 -C 3 -H 3 moiety did not. Cyclo(L-Pro-L-Xxx) epimerized to cyclo(D-Pro-L-Xxx), while cyclo(L-Pro-D-Xxx) did not change.

Registration of N619 to N640 grain sorghum lines with waxy or wild-type endosperm

USDA-ARS?s Scientific Manuscript database

Sorghum [Sorghum bicolor (L.) Moench] lines A N619 to A N636 (Reg. No. GS-XXX, PI 670134 to Reg. No. GS-XXX, PI 670151); B N619 to B N636 (Reg. No. GS-XXX, PI 671777 to Reg. No. GS-XXX, PI 671794); and R N637 to R N640 (Reg. No. GS-XXX, PI 670152 to Reg. No. GS-XXX, PI 670155) comprise nine pairs of...

78 FR 54377 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-04

... family THSA P/N 47145-XXX (where XXX stands for any numerical value) ballscrews might be affected by this... requires repetitive detailed inspections of the ballscrew lower splines of THSAs having P/N 47145-XXX to... ballscrew shaft and tie-rod splines on any THSA having P/N 47145-XXX (where XXX stands for any numerical...

78 FR 12988 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-26

... investigations have also concluded that A320 family THSA P/N 47145-XXX (where XXX stands for any numerical [[Page... ballscrew lower splines of THSAs having P/N 47145-XXX to detect corrosion and, depending on findings, the... tie-rod splines on any THSA having P/N 47145-XXX (where XXX stands for any numerical value) to...

76 FR 25727 - Self-Regulatory Organizations; Chicago Stock Exchange, Inc.; Notice of Filing of Proposed Rule...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-05

... transactions (former Article XXX, Rule 5), record of orders (former Article XXX, Rule 11), submission of the Co... (former Article XXX, Rule 2), competitive basis rule (former Article XXX, Rule 3), BEST rule (former...

Antenatal Diagnosis of an XXX Female

PubMed Central

Krone, Lawrence R.; Prichard, Lorraine L.; Bradshaw, Christy L.; Jones, Oliver W.; Peterson, Raymond M.; Dixson, Barbara K.

1975-01-01

This report describes the first antenatal diagnosis of an XXX female. Over 150 postnatal cases of XXX females have been described. There is no specific phenotype associated with the sex chromosome abnormality and most such persons are fertile. The frequency of XXX females in mental institutions is 3.9 per 1,000 female subjects whereas the frequency in consecutive newborn infants is 1.1 per 1,000 newborns. Chi-square analysis shows this difference cannot be due to chance. On the other hand, data from consecutive newborn studies suggest that intellectual development in XXX newborns is within normal range. Available evidence favors normal development in XXX female infants although the risk for developmental disabilities may be higher for the XXX than for the XX infant. ImagesFigure 1. PMID:1154778

40 CFR 86.095-35 - Labeling.

Code of Federal Regulations, 2013 CFR

2013-07-01

... certified to meet U.S. EPA standards for a useful-life period of XXX miles or XXX hours of operation... engine has a primary intended service application as a XXX heavy-duty engine.” (The primary intended... appropriate model year U.S. Environmental Protection Agency regulations which apply to XXX-fueled heavy-duty...

40 CFR 86.095-35 - Labeling.

Code of Federal Regulations, 2014 CFR

2014-07-01

... to meet U.S. EPA standards for a useful-life period of XXX miles or XXX hours of operation, whichever... has a primary intended service application as a XXX heavy-duty engine.” (The primary intended service... appropriate model year U.S. Environmental Protection Agency regulations which apply to XXX-fueled heavy-duty...

Registration of cytoplasmic male-sterile oilseed sunflower genetic stocks CMS GIG2 and CMS GIG2-RV, and fertility restoration lines RF GIG2-MAX 1631 and RF GIG2-MAX 1631-RV

USDA-ARS?s Scientific Manuscript database

Two cytoplasmic male-sterile (CMS) oilseed sunflower (Helianthus annuus L.) genetic stocks, CMS GIG2 (Reg. No. xxx, PI xxxx), and CMS GIG2-RV (Reg. No. xxx, PI xxxx), and corresponding fertility restoration lines RF GIG2-MAX 1631 (Reg. No. xxx, PI xxxx) and RF GIG2-MAX 1631-RV (Reg. No. xxx, PI xxx...

40 CFR 86.095-35 - Labeling.

Code of Federal Regulations, 2011 CFR

2011-07-01

... certified to meet U.S. EPA standards for a useful-life period of XXX miles or XXX hours of operation... engine has a primary intended service application as a XXX heavy-duty engine.” (The primary intended... regulations which apply to XXX-fueled heavy-duty vehicles. (F) Vehicles granted final admission under § 85...

49 CFR 575.6 - Requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... statement “The combined weight of occupants and cargo should never exceed XXX kg or XXX lbs.” on your... your vehicle. (3) Subtract the combined weight of the driver and passengers from XXX kg or XXX lbs. (4... the “XXX” amount equals 1400 lbs. and there will be five 150 lb passengers in your vehicle, the amount...

49 CFR 575.6 - Requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... statement “The combined weight of occupants and cargo should never exceed XXX kg or XXX lbs.” on your... your vehicle. (3) Subtract the combined weight of the driver and passengers from XXX kg or XXX lbs. (4... the “XXX” amount equals 1400 lbs. and there will be five 150 lb passengers in your vehicle, the amount...

40 CFR 86.095-35 - Labeling.

Code of Federal Regulations, 2012 CFR

2012-07-01

...: “This engine has been certified to meet U.S. EPA standards for a useful-life period of XXX miles or XXX... statement: “This engine has a primary intended service application as a XXX heavy-duty engine.” (The primary... regulations which apply to XXX-fueled heavy-duty vehicles. (F) Vehicles granted final admission under § 85...

49 CFR 575.6 - Requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... statement “The combined weight of occupants and cargo should never exceed XXX kg or XXX lbs.” on your... your vehicle. (3) Subtract the combined weight of the driver and passengers from XXX kg or XXX lbs. (4... the “XXX” amount equals 1400 lbs. and there will be five 150 lb passengers in your vehicle, the amount...

49 CFR 575.6 - Requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... statement “The combined weight of occupants and cargo should never exceed XXX kg or XXX lbs.” on your... your vehicle. (3) Subtract the combined weight of the driver and passengers from XXX kg or XXX lbs. (4... the “XXX” amount equals 1400 lbs. and there will be five 150 lb passengers in your vehicle, the amount...

Establishment and Discontinuance Criteria for Runway Visual Range (RVR) at Category I Precision Landing System Runway

DTIC Science & Technology

1987-01-01

ATITN - x.xx 10,000 73,000 General GAAP - x.xx Aviation: 8,900 Military: MILAP - + x.xx 1,900 Subtotal x.xx x RVR System Design Factor x x.xx Subtotal...first three years of operation, ACAP, ATAP, GAAP and MILAP are the numbers of annual instrument approaches by user class, ACITN and ATITN are the...1, falls beneath 0.40. 3. Scope: The above (Phase I) criteria are based primarily on volume of air traffic and frequency and incidence of IFR weather

49 CFR 571.120 - Tire selection and rims and motor home/recreation vehicle trailer load carrying capacity...

Code of Federal Regulations, 2012 CFR

2012-10-01

...: XXX kg or XXX lbs” in block letters with appropriate values included. (d) The statement “Safety belt equipped seating capacity: XXX” with the appropriate value included. This is the total number of safety belt equipped seating positions. (e) The statement: “CAUTION: A full load of water equals XXX kg or XXX...

49 CFR 571.120 - Tire selection and rims and motor home/recreation vehicle trailer load carrying capacity...

Code of Federal Regulations, 2014 CFR

2014-10-01

...: XXX kg or XXX lbs” in block letters with appropriate values included. (d) The statement “Safety belt equipped seating capacity: XXX” with the appropriate value included. This is the total number of safety belt equipped seating positions. (e) The statement: “CAUTION: A full load of water equals XXX kg or XXX...

49 CFR 571.120 - Tire selection and rims and motor home/recreation vehicle trailer load carrying capacity...

Code of Federal Regulations, 2013 CFR

2013-10-01

...: XXX kg or XXX lbs” in block letters with appropriate values included. (d) The statement “Safety belt equipped seating capacity: XXX” with the appropriate value included. This is the total number of safety belt equipped seating positions. (e) The statement: “CAUTION: A full load of water equals XXX kg or XXX...

49 CFR 571.120 - Tire selection and rims and motor home/recreation vehicle trailer load carrying capacity...

Code of Federal Regulations, 2011 CFR

2011-10-01

...: XXX kg or XXX lbs” in block letters with appropriate values included. (d) The statement “Safety belt equipped seating capacity: XXX” with the appropriate value included. This is the total number of safety belt equipped seating positions. (e) The statement: “CAUTION: A full load of water equals XXX kg or XXX...

78 FR 34092 - Lock+ Hydro Friends Fund XXX, LLC; FFP Project 121, LLC; Notice of Competing Preliminary Permit...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-06

.... 14504-000] Lock+ Hydro Friends Fund XXX, LLC; FFP Project 121, LLC; Notice of Competing Preliminary... Applications Lock+ Hydro Friends Fund XXX, LLC and FFP Project 121, LLC filed preliminary permit applications... regular business day. See id. at 385.2001(a)(2). Lock+ Hydro Friends Fund XXX, LLC's application is for a...

Intestinal atresia, encephalocele, and cardiac malformations in infants with 47,XXX: Expansion of the phenotypic spectrum and a review of the literature.

PubMed

Bağci, Soyhan; Müller, Andreas; Franz, Axel; Heydweiller, Andreas; Berg, Christoph; Nöthen, Markus M; Bartmann, Peter; Reutter, Heiko

2010-01-01

Identification of the 47,XXX karyotype often occurs adventitiously during prenatal fetal karyotyping in cases of advanced maternal age. Although most females with 47,XXX appear healthy at birth, various types of congenital malformations have been reported, of which urinary tract anomalies are the most frequent. We report on 2 newborns with 47,XXX and congenital cardiac defects, one of whom had duodenal atresia and the other an occipital encephalocele. This expands the spectrum of malformations reported in association with the triple-X syndrome. We also present a review of the literature on non-urinary tract malformations in females with 47,XXX. We conclude that prenatal identification of the 47,XXX karyotype is an indication for detailed fetal ultrasonography which should include examination of multiple organ systems. Such prenatal screening for possible associated congenital malformations should help to ensure optimal perinatal clinical management of 47,XXX cases. 2010 S. Karger AG, Basel.

17 CFR 240.15c3-3a - Exhibit A-formula for determination reserve requirement of brokers and dealers under § 240.15c3-3.

Code of Federal Regulations, 2013 CFR

2013-04-01

... balances in customers' security accounts. (See Note A) $XXX 2. Monies borrowed collateralized by securities carried for the accounts of customers (See Note B.) XXX 3. Monies payable against customers' securities loaned (See Note C.) XXX 4. Customers' securities failed to receive (See Note D.) XXX 5. Credit balances...

17 CFR 240.15c3-3a - Exhibit A-formula for determination reserve requirement of brokers and dealers under § 240.15c3-3.

Code of Federal Regulations, 2011 CFR

2011-04-01

... balances in customers' security accounts. (See Note A) $XXX 2. Monies borrowed collateralized by securities carried for the accounts of customers (See Note B.) XXX 3. Monies payable against customers' securities loaned (See Note C.) XXX 4. Customers' securities failed to receive (See Note D.) XXX 5. Credit balances...

17 CFR 240.15c3-3a - Exhibit A-Formula for determination of customer and PAB account reserve requirements of brokers...

Code of Federal Regulations, 2014 CFR

2014-04-01

... balances and other credit balances in customers' security accounts. (See Note A) XXX 2. Monies borrowed collateralized by securities carried for the accounts of customers (See Note B) XXX 3. Monies payable against customers' securities loaned (See Note C) XXX 4. Customers' securities failed to receive (See Note D) XXX 5...

17 CFR 240.15c3-3a - Exhibit A-formula for determination reserve requirement of brokers and dealers under § 240.15c3-3.

Code of Federal Regulations, 2012 CFR

2012-04-01

... balances in customers' security accounts. (See Note A) $XXX 2. Monies borrowed collateralized by securities carried for the accounts of customers (See Note B.) XXX 3. Monies payable against customers' securities loaned (See Note C.) XXX 4. Customers' securities failed to receive (See Note D.) XXX 5. Credit balances...

77 FR 23241 - Lock+ Hydro Friends Fund XXX, LLC; Notice of Intent To File License Application, Filing of Pre...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-18

... Friends Fund XXX, LLC; Notice of Intent To File License Application, Filing of Pre-Application Document.... Date Filed: February 20, 2012. d. Submitted By: Lock+ Hydro Friends Fund XXX, LLC. e. Name of Project... Applicant Contact: Mr. Mark R. Stover, Lock+\\TM\\ Hydro Friends Fund XXX, c/o Hydro Green Energy, LLC, 900...

75 FR 52486 - Disclosures of Return Information Reflected on Returns to Officers and Employees of the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-26

... 301.6103(j)(1)-1 is amended by adding paragraphs (b)(3)(xxix) and (b)(3)(xxx), and revising paragraph... Federal Register]. (xxx) [The text of proposed Sec. 301.6103(j)(1)-1(b)(3)(xxx) is the same as the text of Sec. 301.6103(j)(1)-1T(b)(3)(xxx) published elsewhere in this issue of the Federal Register...

Joint Oil Analysis Program Spectrometer Standards SCP Science (Conostan) Qualification Report for D19-0, D3-100, and D12-XXX Series Standards

DTIC Science & Technology

2015-05-20

Joint Oil Analysis Program Spectrometer Standards SCP Science (Conostan) Qualification Report For D19-0, D3-100, and D12- XXX Series Standards NF...Candidate Type D19-0 ICP-AES Results ..................................................................... 4 Table V. Candidate Type D12- XXX ...Physical Property Results .................................................. 5 Table VI. Candidate Type D12- XXX Rotrode-AES Results

Spontaneous pregnancy in a woman with 45,X/47,XXX mosaicism in both serum and germ cell lines. A case report.

PubMed

Eblen, Abby C; Nakajima, Steve T

2003-02-01

This is the first published case report of pregnancy in a women with 45, X/47, XXX mosaicism in both blood and germ cell lines. The patient conceived, and analysis of ovarian tissue confirmed a karyotype of 45, X/47, XXX. Women with a 45, X/47, XXX karyotype in the germ cell line can conceive, as this case demonstrates.

High Level Design for Distributed Application Instrumentation.

DTIC Science & Technology

1992-09-01

true branch ,TRUE DD-path5 FALSE false branch SEXI .__T DECISION-TO-DECISION PATH EXAMPLE FIGURE 2 4.0 AUTOMATED TESTING TOOLS Manually testing...I I x l- I lE-4 I XX I WI I x I IH I E- 1>4 I IZI X XX I Z ~It X X XX w 1 0 1 XXX x X Il- I E-4l XXW x x X I c)l I XX x x X I4 l l XXX I X x (𔃾 l...I I lC1l XXX x X III xXX X x x X I WI rXX X X x X I I II xXX X X x I i 111 I 1W 0~l XXX X X XX X I1 10.01 XXXX x X XX x I HI0 IW 01 XXXX x Xx XX X X I

Characterization of Nα-Fmoc-protected dipeptide isomers by electrospray ionization tandem mass spectrometry (ESI-MS(n)): effect of protecting group on fragmentation of dipeptides.

PubMed

Ramesh, M; Raju, B; Srinivas, R; Sureshbabu, V V; Vishwanatha, T M; Hemantha, H P

2011-07-30

A series of positional isomeric pairs of Fmoc-protected dipeptides, Fmoc-Gly-Xxx-OY/Fmoc-Xxx-Gly-OY (Xxx=Ala, Val, Leu, Phe) and Fmoc-Ala-Xxx-OY/Fmoc-Xxx-Ala-OY (Xxx=Leu, Phe) (Fmoc=[(9-fluorenylmethyl)oxy]carbonyl) and Y=CH(3)/H), have been characterized and differentiated by both positive and negative ion electrospray ionization ion-trap tandem mass spectrometry (ESI-IT-MS(n)). In contrast to the behavior of reported unprotected dipeptide isomers which mainly produce y(1)(+) and/or a(1)(+) ions, the protonated Fmoc-Xxx-Gly-OY, Fmoc-Ala-Xxx-OY and Fmoc-Xxx-Ala-OY yield significant b(1)(+) ions. These ions are formed, presumably with stable protonated aziridinone structures. However, the peptides with Gly- at the N-terminus do not form b(1)(+) ions. The [M+H](+) ions of all the peptides undergo a McLafferty-type rearrangement followed by loss of CO(2) to form [M+H-Fmoc+H](+). The MS(3) collision-induced dissociation (CID) of these ions helps distinguish the pairs of isomeric dipeptides studied in this work. Further, negative ion MS(3) CID has also been found to be useful for differentiating these isomeric peptide acids. The MS(3) of [M-H-Fmoc+H](-) of isomeric peptide acids produce c(1)(-), z(1)(-) and y(1)(-) ions. Thus the present study of Fmoc-protected peptides provides additional information on mass spectral characterization of the dipeptides and distinguishes the positional isomers. Copyright © 2011 John Wiley & Sons, Ltd.

Evaluation of the Total Petroleum Hydrocarbon Standard for Cleanup of Petroleum Contaminated Sites

DTIC Science & Technology

1993-09-01

100-500 20-100 Hawaii .05-1.7 10-21 1.4-7 Idaho 40-200 Illinois 11.705 0.005 Indiana X 20 Iowa 100 Kansas 100 1.4 XXX Kentucky 1 Louisiana X * * Maine...100 Hawaii 0.5-1.7 10-20 1.4-7 XXX Idaho 100 llinois 11.705 0.005 XXX Indiana X 20 Iowa 100 Kansas 100 1.4 XXX Kentucky XXX Louisiana X Maine X FIELD...Alaska X X Arizona X X Arkansas X X California X X X Colorado X X Connecticut (I) Delaware X X lorida X Georstia, X IX I Hawaii X X Idaho X X illinois X X

A variant System I for cytochrome c biogenesis in archaea and some bacteria has a novel CcmE and no CcmH.

PubMed

Allen, James W A; Harvat, Edgar M; Stevens, Julie M; Ferguson, Stuart J

2006-09-04

C-type cytochromes are characterized by post-translational covalent attachment of heme to thiols that occur in a Cys-Xxx-Xxx-Cys-His motif. Three distinct biogenesis systems are known for this heme attachment. Archaea are now shown to contain a significantly modified form of cytochrome c maturation System I (the Ccm system). The most notable adaptation relative to the well-studied apparatus from proteobacteria and plants is a novel form of the heme chaperone CcmE, lacking the highly conserved histidine that covalently binds heme and is essential for function in Escherichia coli. In most archaeal CcmEs this histidine, normally found in a His-Xxx-Xxx-Xxx-Tyr motif, is replaced by a cysteine residue that occurs in a Cys-Xxx-Xxx-Xxx-Tyr motif. The CcmEs from two halobacteria contain yet another form of CcmE, having HxxxHxxxH approximately corresponding in alignment to the H/CxxxY motif. The CxxxY-type of CcmE is, surprisingly, also found in some bacterial genomes (including Desulfovibrio species). All of the modified CcmEs cluster together in a phylogenetic tree, as do other Ccm proteins from the same organisms. Significantly, CcmH is absent from all of the complete archaeal genomes we have studied, and also from most of the bacterial genomes that have CxxxY-type CcmE.

Pregnancy outcomes in prenatally diagnosed 47, XXX and 47, XYY syndromes: a 30-year French, retrospective, multicentre study.

PubMed

Gruchy, Nicolas; Blondeel, Eleonore; Le Meur, Nathalie; Joly-Hélas, Géraldine; Chambon, Pascal; Till, Marianne; Herbaux, Martine; Vigouroux-Castera, Adeline; Coussement, Aurélie; Lespinasse, James; Amblard, Florence; Jimenez Pocquet, Mélanie; Lebel-Roy, Camille; Carré-Pigeon, Frédérique; Flori, Elisabeth; Mugneret, Francine; Jaillard, Sylvie; Yardin, Catherine; Harbuz, Radu; Collonge-Rame, Marie-Agnès; Vago, Philippe; Valduga, Mylène; Leporrier, Nathalie; Vialard, François

2016-06-01

Sex chromosome aneuploidies are frequently detected fortuitously in a prenatal diagnosis. Most cases of 47, XXX and 47, XYY syndromes are diagnosed in this context, and parents are thus faced with an unexpected situation. The objective of the present study was to characterize a French cohort of prenatally diagnosed cases of 47, XXX and 47, XYY and to evaluate the termination of pregnancy (TOP) rate before and after France's implementation of multidisciplinary centres for prenatal diagnosis in 1997. This retrospective study identified respectively 291 and 175 cases of prenatally diagnosed 47, XXX and 47, XYY between 1976 and 2012. For each case, the indication, maternal age, karyotype and outcome were recorded. Most diagnoses of the two conditions were fortuitous. The occurrence of 47, XXX was associated with advanced maternal age. The overall TOP rate was higher for 47, XXX (22.9%) than for 47, XYY (14.6%), although this difference was not statistically significant. However, the TOP rates fell significantly after 1997 (from 41.1% to 11.8% for 47, XXX and from 25.8% to 6.7% for 47, XYY). The TOP rates after prenatal diagnoses of 47, XXX and 47, XYY fell significantly after 1997, following France's implementation of multidisciplinary centres for prenatal diagnosis. © 2016 John Wiley & Sons, Ltd. © 2016 John Wiley & Sons, Ltd.

Poor socio-economic status in 47,XXX --an unexpected effect of an extra X chromosome.

PubMed

Stochholm, Kirstine; Juul, Svend; Gravholt, Claus H

2013-06-01

One of the most common sex chromosomal abnormalities in females is 47,XXX syndrome, which is characterized by tall stature and reduced IQ, but with a variable phenotype. In order to elaborate on the characteristics of this syndrome, we undertook an investigation in all diagnosed 47,XXX females at risk in Denmark and compared their socio-economic status with an age-matched cohort of the female background population as well as with all Danes diagnosed with Turner syndrome. We focused on cohabitation, motherhoods, income, education, retirement and convictions. Furthermore, we investigated whether some of these parameters influenced the increased mortality identified previously. Thus, socio-economic data were retrieved in 108 47,XXX persons, 10,297 controls, and 831 with Turner syndrome. Comparing the 47,XXX persons with their controls, we identified significantly decreased numbers of first partnership, number of mothers, and number of persons with an education in 47,XXX persons. Significantly more 47,XXX persons retired. In the younger age groups an increased number had income below the median among controls. The increased mortality identified previously was not explained by the reduced number of partnerships or the reduced number of persons with an education. Comparing the 47,XXX persons with Turner syndrome persons, we identified increased number of first partnership, number of mothers, and reduced level of education. We hypothesize that the significantly decreased number of 47,XXX persons becoming mothers could be due to hypogonadism in some. The affected socio-economic status suggests that the presence of an extra X chromosome has more detrimental effects than previously appreciated. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

16 CFR 309.15 - Posting of non-liquid alternative vehicle fuel rating.

Code of Federal Regulations, 2012 CFR

2012-01-01

...): (1) “CNG” “Minimum” “XXX%” “Methane” (2) “Hydrogen” “Minimum” “XXX%” “Hydrogen” (f) The following... illustration of compliance with this part: “Electricity” “XX kW” “XXX vac/XX amps” “Inductive” (g) When you...

16 CFR 309.15 - Posting of non-liquid alternative vehicle fuel rating.

Code of Federal Regulations, 2014 CFR

2014-01-01

...): (1) “CNG” “Minimum” “XXX%” “Methane” (2) “Hydrogen” “Minimum” “XXX%” “Hydrogen” (f) The following... illustration of compliance with this part: “Electricity” “XX kW” “XXX vac/XX amps” “Inductive” (g) When you...

16 CFR 309.15 - Posting of non-liquid alternative vehicle fuel rating.

Code of Federal Regulations, 2011 CFR

2011-01-01

...): (1) “CNG” “Minimum” “XXX%” “Methane” (2) “Hydrogen” “Minimum” “XXX%” “Hydrogen” (f) The following... illustration of compliance with this part: “Electricity” “XX kW” “XXX vac/XX amps” “Inductive” (g) When you...

16 CFR 309.15 - Posting of non-liquid alternative vehicle fuel rating.

Code of Federal Regulations, 2013 CFR

2013-01-01

...): (1) “CNG” “Minimum” “XXX%” “Methane” (2) “Hydrogen” “Minimum” “XXX%” “Hydrogen” (f) The following... illustration of compliance with this part: “Electricity” “XX kW” “XXX vac/XX amps” “Inductive” (g) When you...

76 FR 4378 - Sunshine Act Meetings; Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-25

... Directors and non- voting Non-Directors to committees. 9. Consider and act on Resolution 2011-XXX thanking... participation on the 2010 Search Committee for LSC President. 12. Consider and act on Resolution 2011-XXX dissolving the 2010 Search Committee for LSC President. 13. Consider and act on Resolution 2011-XXX...

16 CFR 309.15 - Posting of non-liquid alternative vehicle fuel rating.

Code of Federal Regulations, 2010 CFR

2010-01-01

...): (1) “CNG” “Minimum” “XXX%” “Methane” (2) “Hydrogen” “Minimum” “XXX%” “Hydrogen” (f) The following... illustration of compliance with this part: “Electricity” “XX kW” “XXX vac/XX amps” “Inductive” (g) When you...

75 FR 32719 - Acquisition Regulation: Agency Supplementary Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-09

.... * * * * * COUNTERINTELLIGENCE (XXX 20XX) * * * * * 16. Section 970.5223-3 is amended by: a. Revising the date of the provision... SITES (XXX 20XX) * * * * * (b) * * * DOE may grant an extension to the notification or implementation... SUBSTANCE ABUSE PROGRAMS AT DOE SITES (XXX 20XX) * * * * * (c) Subcontracts. (1) The Contractor agrees to...

Duodenal atresia in an infant with triple-X syndrome: a new associated malformation in 47,XXX.

PubMed

Rolle, Udo; Linse, Barbara; Glasow, Simone; Sandig, Klaus Rainer; Richter, Thomas; Till, Holger

2007-08-01

An association between the triple-X syndrome (47,XXX) and gastrointestinal malformations is extremely rare. Most 47,XXX patients present with a normal phenotype, but genitourinary malformations have been described. We report a case of a child with 47,XXX and duodenal atresia. Antenatal ultrasound scan showed a dilated fetal stomach and upper part of the duodenum (double bubble phenomenon) at 31 weeks of gestation in a 31-year-old woman with polyhydramnion. The amniotic fluid karyotype showed 47,XXX. After a scheduled delivery, duodenal atresia was confirmed and treated with duodeno-duodenostomy. The possible association of gastrointestinal and genitourinary tract anomalies requires a detailed postnatal clinical investigation and ultrasonographic examination of the abdomen, retroperitoneum, and pelvis on all triple-X syndrome patients. 2007 Wiley-Liss, Inc.

78 FR 49509 - Lock+ Hydro Friends Fund XXX, LLC; FFP Project 121, LLC; Notice Announcing Preliminary Permit...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [ Project No. 13625-003; Project No. 14504-000] Lock+ Hydro Friends Fund XXX, LLC; FFP Project 121, LLC; Notice Announcing Preliminary Permit... and Jefferson County, Ohio. The applications were filed by Lock+ Hydro Friends Fund XXX, LLC for...

77 FR 36331 - Nineteenth Meeting: RTCA Special Committee 213, Enhanced Flight Vision Systems/Synthetic Vision...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-18

... Document--Draft DO-XXX, Minimum Aviation Performance Standards (MASPS) for an Enhanced Flight Vision System... Discussion (9:00 a.m.-5:00 p.m.) Provide Comment Resolution of Document--Draft DO-XXX, Minimum Aviation.../Approve FRAC Draft for PMC Consideration--Draft DO- XXX, Minimum Aviation Performance Standards (MASPS...

Bethe vectors for XXX-spin chain

NASA Astrophysics Data System (ADS)

Burdík, Čestmír; Fuksa, Jan; Isaev, Alexei

2014-11-01

The paper deals with algebraic Bethe ansatz for XXX-spin chain. Generators of Yang-Baxter algebra are expressed in basis of free fermions and used to calculate explicit form of Bethe vectors. Their relation to N-component models is used to prove conjecture about their form in general. Some remarks on inhomogeneous XXX-spin chain are included.

X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome.

PubMed

Liu, Ke; Kurien, Biji T; Zimmerman, Sarah L; Kaufman, Kenneth M; Taft, Diana H; Kottyan, Leah C; Lazaro, Sara; Weaver, Carrie A; Ice, John A; Adler, Adam J; Chodosh, James; Radfar, Lida; Rasmussen, Astrid; Stone, Donald U; Lewis, David M; Li, Shibo; Koelsch, Kristi A; Igoe, Ann; Talsania, Mitali; Kumar, Jay; Maier-Moore, Jacen S; Harris, Valerie M; Gopalakrishnan, Rajaram; Jonsson, Roland; Lessard, James A; Lu, Xianglan; Gottenberg, Jacques-Eric; Anaya, Juan-Manuel; Cunninghame-Graham, Deborah S; Huang, Andrew J W; Brennan, Michael T; Hughes, Pamela; Illei, Gabor G; Miceli-Richard, Corinne; Keystone, Edward C; Bykerk, Vivian P; Hirschfield, Gideon; Xie, Gang; Ng, Wan-Fai; Nordmark, Gunnel; Eriksson, Per; Omdal, Roald; Rhodus, Nelson L; Rischmueller, Maureen; Rohrer, Michael; Segal, Barbara M; Vyse, Timothy J; Wahren-Herlenius, Marie; Witte, Torsten; Pons-Estel, Bernardo; Alarcon-Riquelme, Marta E; Guthridge, Joel M; James, Judith A; Lessard, Christopher J; Kelly, Jennifer A; Thompson, Susan D; Gaffney, Patrick M; Montgomery, Courtney G; Edberg, Jeffrey C; Kimberly, Robert P; Alarcón, Graciela S; Langefeld, Carl L; Gilkeson, Gary S; Kamen, Diane L; Tsao, Betty P; McCune, W Joseph; Salmon, Jane E; Merrill, Joan T; Weisman, Michael H; Wallace, Daniel J; Utset, Tammy O; Bottinger, Erwin P; Amos, Christopher I; Siminovitch, Katherine A; Mariette, Xavier; Sivils, Kathy L; Harley, John B; Scofield, R Hal

2016-05-01

More than 80% of autoimmune disease predominantly affects females, but the mechanism for this female bias is poorly understood. We suspected that an X chromosome dose effect accounts for this, and we undertook this study to test our hypothesis that trisomy X (47,XXX; occurring in ∼1 in 1,000 live female births) would be increased in patients with female-predominant diseases (systemic lupus erythematosus [SLE], primary Sjögren's syndrome [SS], primary biliary cirrhosis, and rheumatoid arthritis [RA]) compared to patients with diseases without female predominance (sarcoidosis) and compared to controls. All subjects in this study were female. We identified subjects with 47,XXX using aggregate data from single-nucleotide polymorphism arrays, and, when possible, we confirmed the presence of 47,XXX using fluorescence in situ hybridization or quantitative polymerase chain reaction. We found 47,XXX in 7 of 2,826 SLE patients and in 3 of 1,033 SS patients, but in only 2 of 7,074 controls (odds ratio in the SLE and primary SS groups 8.78 [95% confidence interval 1.67-86.79], P = 0.003 and odds ratio 10.29 [95% confidence interval 1.18-123.47], P = 0.02, respectively). One in 404 women with SLE and 1 in 344 women with SS had 47,XXX. There was an excess of 47,XXX among SLE and SS patients. The estimated prevalence of SLE and SS in women with 47,XXX was ∼2.5 and ∼2.9 times higher, respectively, than that in women with 46,XX and ∼25 and ∼41 times higher, respectively, than that in men with 46,XY. No statistically significant increase of 47,XXX was observed in other female-biased diseases (primary biliary cirrhosis or RA), supporting the idea of multiple pathways to sex bias in autoimmunity. © 2016, American College of Rheumatology.

40 CFR 86.1807-01 - Vehicle labeling.

Code of Federal Regulations, 2014 CFR

2014-07-01

... statement: “This Vehicle Conforms to U.S. EPA Regulations Applicable to XXX-Fueled 20XX Model Year New Motor... Applicable to XXX-Fueled 20XX Model Year New Light-Duty Trucks.” (C) For medium-duty passenger vehicles, the statement: “This Vehicle Conforms to U.S. EPA Regulations Applicable to XXX-fueled 20XX Model Year New...

40 CFR 86.1807-01 - Vehicle labeling.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Conforms to U.S. EPA Regulations Applicable to XXX-Fueled 20XX Model Year New Motor Vehicles.” (B) For light-duty trucks, the statement: “This Vehicle Conforms to U.S. EPA Regulations Applicable to XXX...: “This Vehicle Conforms to U.S. EPA Regulations Applicable to XXX-fueled 20XX Model Year New Medium-Duty...

40 CFR 86.1807-01 - Vehicle labeling.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Conforms to U.S. EPA Regulations Applicable to XXX-Fueled 20XX Model Year New Motor Vehicles.” (B) For light-duty trucks, the statement: “This Vehicle Conforms to U.S. EPA Regulations Applicable to XXX...: “This Vehicle Conforms to U.S. EPA Regulations Applicable to XXX-fueled 20XX Model Year New Medium-Duty...

40 CFR 86.1807-01 - Vehicle labeling.

Code of Federal Regulations, 2012 CFR

2012-07-01

... XXX-Fueled 20XX Model Year New Motor Vehicles.” (B) For light-duty trucks, the statement: “This Vehicle Conforms to U.S. EPA Regulations Applicable to XXX-Fueled 20XX Model Year New Light-Duty Trucks... Applicable to XXX-fueled 20XX Model Year New Medium-Duty Passenger Vehicles.” (D) For heavy-duty vehicles...

77 FR 30566 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-23

... current Grandfathered Rules, Chapter XXX, Section 2(a). See also BX Rule 9211. A disciplinary proceeding... Consent. See Chapter XXX, Section 10 and Chapter XXXIV. \\9\\ Compare to American Stock Exchange (``AMEX... Floor Decorum Policies) of Chapter XVIII (Conduct) is being amended to reflect that Chapter XXX is being...

40 CFR 86.1807-01 - Vehicle labeling.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Conforms to U.S. EPA Regulations Applicable to XXX-Fueled 20XX Model Year New Motor Vehicles.” (B) For light-duty trucks, the statement: “This Vehicle Conforms to U.S. EPA Regulations Applicable to XXX...: “This Vehicle Conforms to U.S. EPA Regulations Applicable to XXX-fueled 20XX Model Year New Medium-Duty...

75 FR 52917 - Defense Federal Acquisition Regulation Supplement (DFARS); Warranty Tracking of Serialized Items...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-30

....211-7003 by revising the clause date to read ``(XXX 2010)'' and, at paragraph (a), by revising the... following provision: Notice of Warranty Tracking of Serialized Items (XXX 2010) (a) Definition. ``Unique...: Warranty Tracking of Serialized Items (XXX 2010) (a) Definitions. As used in this clause-- DoD Item Unique...

75 FR 52458 - Disclosures of Return Information Reflected on Returns to Officers and Employees of the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-26

.... Adding paragraphs (b)(3)(xxix) and (b)(3)(xxx). 0 3. Revising paragraph (e). 0 4. Adding a sentence at... reported on Form 1096 transmitting Forms 1099-MISC. (xxx) Total amount reported on Form 1096 transmitting Forms 1099- MISC. * * * * * (e) Effective/applicability date. Paragraph (b)(3)(xxix) through (b)(3)(xxx...

X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased 47,XXX in Systemic Lupus Erythematosus and Sjögren’s Syndrome

PubMed Central

Liu, Ke; Kurien, Biji T.; Zimmerman, Sarah L.; Kaufman, Kenneth M.; Taft, Diana H.; Kottyan, Leah C.; Lazaro, Sara; Weaver, Carrie A.; Ice, John A.; Adler, Adam J.; Chodosh, James; Radfar, Lida; Rasmussen, Astrid; Stone, Donald U.; Lewis, David M.; Li, Shibo; Koelsch, Kristi A.; Igoe, Ann; Talsania, Mitali; Kumar, Jay; Maier-Moore, Jacen S.; Harris, Valerie M.; Gopalakrishnan, Rajaram; Jonsson, Roland; Lessard, James A.; Lu, Xianglan; Gottenberg, Jacques-Eric; Anaya, Juan-Manuel; Cunninghame-Graham, Deborah S.; Huang, Andrew J. W.; Brennan, Michael T.; Hughes, Pamela; Illei, Gabor G.; Miceli-Richard, Corinne; Keystone, Edward C.; Bykerk, Vivian P.; Hirschfield, Gideon; Xie, Gang; Ng, Wan-Fai; Nordmark, Gunnel; Eriksson, Per; Omdal, Roald; Rhodus, Nelson L.; Rischmueller, Maureen; Rohrer, Michael; Segal, Barbara M.; Vyse, Timothy J.; Wahren-Herlenius, Marie; Witte, Torsten; Pons-Estel, Bernardo; Alarcon-Riquelme, Marta E.; Guthridge, Joel M.; James, Judith A.; Lessard, Christopher J.; Kelly, Jennifer A.; Thompson, Susan D.; Gaffney, Patrick M.; Montgomery, Courtney G.; Edberg, Jeffrey C; Kimberly, Robert P; Alarcón, Graciela S.; Langefeld, Carl L.; Gilkeson, Gary S.; Kamen, Diane L.; Tsao, Betty P.; McCune, W. Joseph; Salmon, Jane E.; Merrill, Joan T.; Weisman, Michael H; Wallace, Daniel J; Utset, Tammy O; Bottinger, Erwin P.; Amos, Christopher I.; Siminovitch, Katherine A.; Mariette, Xavier; Sivils, Kathy L.

2016-01-01

Objective More than 80% of autoimmune disease is female dominant, but the mechanism for this female bias is poorly understood. We suspected an X chromosome dose effect and hypothesized that trisomy X (47,XXX , 1 in ~1,000 live female births) would be increased in female predominant diseases (e.g. systemic lupus erythematosus [SLE], primary Sjögren’s syndrome [SS], primary biliary cirrhosis [PBC] and rheumatoid arthritis [RA]) compared to diseases without female predominance (sarcoidosis) and controls. Methods We identified 47,XXX subjects using aggregate data from single nucleotide polymorphism (SNP) arrays and confirmed, when possible, by fluorescent in situ hybridization (FISH) or quantitative polymerase chain reaction (q-PCR). Results We found 47,XXX in seven of 2,826 SLE and three of 1,033 SS female patients, but only in two of the 7,074 female controls (p=0.003, OR=8.78, 95% CI: 1.67-86.79 and p=0.02, OR=10.29, 95% CI: 1.18-123.47; respectively). One 47,XXX subject was present for ~404 SLE women and ~344 SS women. 47,XXX was present in excess among SLE and SS subjects. Conclusion The estimated prevalence of SLE and SS in women with 47,XXX was respectively ~2.5 and ~2.9 times higher than in 46,XX women and ~25 and ~41 times higher than in 46,XY men. No statistically significant increase of 47,XXX was observed in other female-biased diseases (PBC or RA), supporting the idea of multiple pathways to sex bias in autoimmunity. PMID:26713507

21 CFR 137.250 - White corn meal.

Code of Federal Regulations, 2014 CFR

2014-04-01

... frame of the same dimensions as the Nos. 12 and 25 and fitted with 72 XXX grits gauze is used as the third sieve. It is referred to hereafter as the No. 72 sieve. The 72 XXX grits gauze has openings... pan shall be considered as the percent passing through a No. 72 XXX grits gauze. [42 FR 14402, Mar. 15...

21 CFR 137.250 - White corn meal.

Code of Federal Regulations, 2013 CFR

2013-04-01

... frame of the same dimensions as the Nos. 12 and 25 and fitted with 72 XXX grits gauze is used as the third sieve. It is referred to hereafter as the No. 72 sieve. The 72 XXX grits gauze has openings... pan shall be considered as the percent passing through a No. 72 XXX grits gauze. [42 FR 14402, Mar. 15...

21 CFR 137.250 - White corn meal.

Code of Federal Regulations, 2012 CFR

2012-04-01

... frame of the same dimensions as the Nos. 12 and 25 and fitted with 72 XXX grits gauze is used as the third sieve. It is referred to hereafter as the No. 72 sieve. The 72 XXX grits gauze has openings... pan shall be considered as the percent passing through a No. 72 XXX grits gauze. [42 FR 14402, Mar. 15...

Towards Understanding the Tandem Mass Spectra of Protonated Oligopeptides. 2: The Proline Effect in Collision-Induced Dissociation of Protonated Ala-Ala-Xxx-Pro-Ala (Xxx = Ala, Ser, Leu, Val, Phe, and Trp)

NASA Astrophysics Data System (ADS)

Bleiholder, Christian; Suhai, Sándor; Harrison, Alex G.; Paizs, Béla

2011-06-01

The product ion spectra of proline-containing peptides are commonly dominated by y n ions generated by cleavage at the N-terminal side of proline residues. This proline effect is investigated in the current work by collision-induced dissociation (CID) of protonated Ala-Ala-Xxx-Pro-Ala (Xxx includes Ala, Ser, Leu, Val, Phe, and Trp) in an electrospray/quadrupole/time-of-flight (QqTOF) mass spectrometer and by quantum chemical calculations on protonated Ala-Ala-Ala-Pro-Ala. The CID spectra of all investigated peptides show a dominant y 2 ion (Pro-Ala sequence). Our computational results show that the proline effect mainly arises from the particularly low threshold energy for the amide bond cleavage N-terminal to the proline residue, and from the high proton affinity of the proline-containing C-terminal fragment produced by this cleavage. These theoretical results are qualitatively supported by the experimentally observed y 2 / b 3 abundance ratios for protonated Ala-Ala-Xxx-Pro-Ala (Xxx = Ala, Ser, Leu, Val, Phe, and Trp). In the post-cleavage phase of fragmentation the N-terminal oxazolone fragment with the Ala-Ala-Xxx sequence and Pro-Ala compete for the ionizing proton for these peptides. As the proton affinity of the oxazolone fragment increases, the y 2 / b 3 abundance ratio decreases.

Towards understanding the tandem mass spectra of protonated oligopeptides. 2: The proline effect in collision-induced dissociation of protonated Ala-Ala-Xxx-Pro-Ala (Xxx = Ala, Ser, Leu, Val, Phe, and Trp).

PubMed

Bleiholder, Christian; Suhai, Sándor; Harrison, Alex G; Paizs, Béla

2011-06-01

The product ion spectra of proline-containing peptides are commonly dominated by y(n) ions generated by cleavage at the N-terminal side of proline residues. This proline effect is investigated in the current work by collision-induced dissociation (CID) of protonated Ala-Ala-Xxx-Pro-Ala (Xxx includes Ala, Ser, Leu, Val, Phe, and Trp) in an electrospray/quadrupole/time-of-flight (QqTOF) mass spectrometer and by quantum chemical calculations on protonated Ala-Ala-Ala-Pro-Ala. The CID spectra of all investigated peptides show a dominant y(2) ion (Pro-Ala sequence). Our computational results show that the proline effect mainly arises from the particularly low threshold energy for the amide bond cleavage N-terminal to the proline residue, and from the high proton affinity of the proline-containing C-terminal fragment produced by this cleavage. These theoretical results are qualitatively supported by the experimentally observed y(2)/b(3) abundance ratios for protonated Ala-Ala-Xxx-Pro-Ala (Xxx = Ala, Ser, Leu, Val, Phe, and Trp). In the post-cleavage phase of fragmentation the N-terminal oxazolone fragment with the Ala-Ala-Xxx sequence and Pro-Ala compete for the ionizing proton for these peptides. As the proton affinity of the oxazolone fragment increases, the y(2)/b(3) abundance ratio decreases.

26 CFR 301.6103(j)(1)-1T - Disclosures of return information reflected on returns to officers and employees of the...

Code of Federal Regulations, 2012 CFR

2012-04-01

... reported on Form 1096 transmitting Forms 1099-MISC. (xxx) Total amount reported on Form 1096 transmitting...) Effective/applicability date. Paragraph (b)(3)(xxix) through (b)(3)(xxx) of this section is applicable to... applicability of paragraphs (b)(3)(xxix) through (b)(3)(xxx) of this section expires on or before August 26...

26 CFR 301.6103(j)(1)-1T - Disclosures of return information reflected on returns to officers and employees of the...

Code of Federal Regulations, 2011 CFR

2011-04-01

... reported on Form 1096 transmitting Forms 1099-MISC. (xxx) Total amount reported on Form 1096 transmitting...) Effective/applicability date. Paragraph (b)(3)(xxix) through (b)(3)(xxx) of this section is applicable to... applicability of paragraphs (b)(3)(xxix) through (b)(3)(xxx) of this section expires on or before August 26...

26 CFR 301.6103(j)(1)-1T - Disclosures of return information reflected on returns to officers and employees of the...

Code of Federal Regulations, 2013 CFR

2013-04-01

... reported on Form 1096 transmitting Forms 1099-MISC. (xxx) Total amount reported on Form 1096 transmitting...) Effective/applicability date. Paragraph (b)(3)(xxix) through (b)(3)(xxx) of this section is applicable to... applicability of paragraphs (b)(3)(xxix) through (b)(3)(xxx) of this section expires on or before August 26...

Registration of F1025, F1026, and F1027 sugarbeet germplasm with low concentrations of sodium, potassium, or amino-nitrogen

USDA-ARS?s Scientific Manuscript database

F1025 (Reg. No. GP-xxx, PI xxxxxx), F1026 (Reg. No. GP-xxx, PI xxxxxx), and F1027 (Reg. No. GP-xxx, PI xxxxxx) sugarbeet (Beta vulgaris L.) germplasm lines, selected for low concentrations of sodium, potassium, and amino-nitrogen, respectively, in the roots, were released by the USDA-ARS and the Nor...

[Phenotypic variability in 47, XXX patients: Clinical report of four new cases].

PubMed

Goldschmidt, Ernesto; Márquez, Marisa; Solari, Andrea; Ziembar, María I; Laudicina, Alejandro

2010-08-01

The 47, XXX karyotype has a frequency of 1 in 1000 female newborns. However, this karyotype is not usually suspected at birth or childhood. These patients are usually diagnosed during adulthood when they develop premature ovarian failure or infertility, because the early phenotype doesn t have any specific features. The study describes four cases and the clinical variability of the 47, XXX karyotype.

78 FR 52856 - Disclosures of Return Information Reflected on Returns to Officers and Employees of the...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-27

... transmitting Forms 1099-MISC (subsections xxix and xxx of section 6103(j)(1)-1T). Special Analyses It has been.... 2. Section 301.6103(j)(1)-1 is amended by: 0 1. Adding paragraphs (b)(3)(xxix) and (b)(3)(xxx). 0 2... documents reported on Form 1096 transmitting Forms 1099-MISC. (xxx) Total amount reported on Form 1096...

Partial epilepsy and 47,XXX karyotype: report of four cases.

PubMed

Roubertie, Agathe; Humbertclaude, Véronique; Leydet, Julie; Lefort, Geneviève; Echenne, Bernard

2006-07-01

Epilepsy is a common finding in chromosomal imbalances, but only a few chromosome abnormalities have a characteristic electro-clinical pattern. Trisomy X is one of the most common sex chromosome abnormalities in females, and is associated with considerable phenotypic variability. This report describes four 47,XXX females with mental deficiency and epilepsy. Although a specific electro-clinical pattern could not be defined, the epileptic phenotypes of these patients share many features; we suggest that the association 47,XXX/epilepsy/mental retardation may not be coincidental. This report also enlarges the clinical spectrum of the 47,XXX phenotype. Moreover, these observations highlight the critical role of chromosome X in epilepsy and mental retardation.

Double trisomy 48,XXX,+18 with multiple dysmorphic features.

PubMed

Jiang, Zi-Yan; Wu, Xiao-Hui; Zou, Chao-Chun

2015-02-01

Chromosomal abnormality is a common cause of congenital anomalies, psychiatric disorders, and mental retardation. However, the double trisomy 48,XXX,+18 is a rare chromosome abnormality. Case report and literature review. A 7-hour-old girl presented to our unit because of poor response after birth. She presented with multiple dysmorphic features, including small for gestational age infant, flat nasal bridge, widely-spaced eyes, the left thumb deformities, flat facial profile, raised sternum, ventricular septal defect, the third lateral brain ventricle enlargement, and small liver. This case expands the spectrum of malformations reported in association with the double trisomy 48,XXX,+18. The literature on 16 fetuses or infants with the 48,XXX,+18 were also reviewed. These data suggested that in patients with clinical features similar to trisomy 18, especially with anomalies of the ears and/or reproductive malformations, double trisomy (48,XXX,+18) should be considered and karyotyping should be performed although it is a rare disease.

Mortality and incidence in women with 47,XXX and variants.

PubMed

Stochholm, Kirstine; Juul, Svend; Gravholt, Claus Højbjerg

2010-02-01

47,XXX syndrome is among the most common sex chromosomal disorders; however, apart from screening surveys, epidemiological data are limited. We report data on 136 women diagnosed with 47,XXX or a compatible karyotype in Denmark during 1963-2008. We identified an incidence of 10.7 per 100,000 liveborn girls, which was lower than expected and was stable during the study period. Age at diagnosis ranged from 0 to 73 years, with a diagnostic delay of 18.2 years or more in half the 47,XXX persons. We compared persons with 47,XXX with an age-matched cohort of the female background population (born same year and month), identified in Statistics Denmark (n = 13,400). Mortality was significantly increased in total with a hazard ratio of 2.5 (1.6-3.9), corresponding to a difference in median survival of 7.7 years. When we divided causes of death into 19 chapters according to the International Classification of Diseases, a generally increased mortality was identified in all informative chapters. Furthermore, we identified significantly increased mortality in cardiovascular diseases, in the chapter concerning chromosomal and congenital defects, and in the chapter of unspecified diseases. Better delineation of the clinical phenotype of 47,XXX is needed; available information does not readily explain the increased mortality. Copyright 2010 Wiley-Liss, Inc.

Flexible xxx-asp/asn and gly-xxx residues of equine cytochrome C in matrix-assisted laser desorption/ionization in-source decay mass spectrometry.

PubMed

Takayama, Mitsuo

2012-01-01

The backbone flexibility of a protein has been studied from the standpoint of the susceptibility of amino acid residues to in-source decay (ISD) in matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS). Residues more susceptible to MALDI-ISD, namely Xxx-Asp/Asn and Gly-Xxx, were identified from the discontinuous intense peak of c'-ions originating from specific cleavage at N-Cα bonds of the backbone of equine cytochrome c. The identity of the residues susceptible to ISD was consistent with the known flexible backbone amides as estimated by hydrogen/deuterium exchange (HDX) experiments. The identity of these flexible amino acid residues (Asp, Asn, and Gly) is consistent with the fact that these residues are preferred in flexible secondary structure free from intramolecular hydrogen-bonded structures such as α-helix and β-sheet. The MALDI-ISD spectrum of equine cytochrome c gave not only intense N-terminal side c'-ions originating from N-Cα bond cleavage at Xxx-Asp/Asn and Gly-Xxx residues, but also C-terminal side complement z'-ions originating from the same cleavage sites. The present study implies that MALDI-ISD can give information about backbone flexibility of proteins, comparable with the protection factors estimated by HDX.

Incidence, puberty, and fertility in 45,X/47,XXX mosaicism: Report of a patient and a literature review.

PubMed

Lim, Han Hyuk; Kil, Hong Ryang; Koo, Sun Hoe

2017-05-09

Turner syndrome (TS), characterized by short stature and premature ovarian failure, is caused by chromosomal aberrations with total or partial loss of one of the two X chromosomes. Spontaneous puberty, menarche, and pregnancy occur in some patients depending on the abnormality of the X. Moreover, spontaneous pregnancy is uncommon (<0.5%) for TS with 45,X monosomy. Among TS patients, 45,X/47,XXX karyotype is extremely rare. Previous reports have demonstrated that TS with 45,X/47,XXX is less severe than common TS due to higher occurrence of puberty (83%), menarche (57-67%), and fertility (14%) and lower occurrence of congenital anomalies (<5%). However, TS mosaicism may not reduce the frequency of short stature. We diagnosed a 10-year-girl with TS with 45,X/47,XXX mosaicism who presented with short stature. She showed mild TS phenotype including short stature but had spontaneous puberty. Based on our case and previous reports, we expect that girls with 45,X/47,XXX mosaicism may progress through puberty normally, without estrogen therapy. Therefore, it is necessary to consider specific guidelines for clinical decisions surrounding pubertal development and fertility in TS with 45,X/47,XXX karyotype. © 2017 Wiley Periodicals, Inc.

Generation of integration-free induced pluripotent stem cells (GZHMUi001-A) by reprogramming peripheral blood mononuclear cells from a 47, XXX syndrome patient.

PubMed

Chen, Yuchang; Ou, Zhanhui; Song, Bing; Xian, Yexing; Ouyang, Shuming; Xie, Yuhuan; Xue, Yanting; Sun, Xiaofang

2017-08-01

47, XXX syndrome is one of several sex-chromosomal aneuploidies, and it has an incidence of approximately 1/1000 in newborn females. Because of heterogeneity in X-inactivation, these patients may exhibit a variety of clinical symptoms. Here, we report the generation of an integration-free human induced pluripotent stem cell line (GZHMUi001-A) by using Sendai virus to reprogram peripheral blood mononuclear cells from a 47, XXX syndrome patient with premature ovarian failure. This 47, XXX iPS cell line has characteristics of pluripotent stem cells and is a useful tool for the investigation of this X chromosome aneuploid disease. Copyright © 2017. Published by Elsevier B.V.

The topological basis realization and the corresponding XXX spin chain

NASA Astrophysics Data System (ADS)

Sun, C. F.; Xue, K.; Wang, G. C.; Zhou, C. C.; Du, G. J.

2011-06-01

In this paper, it is shown that the XXX model can be constructed from the Temperley-Lieb algebra (TLA) generator. We find that the topological basis states are the two eigenstaes of a closed four-qubit Heisenberg XXX spin chain. Specifically, the spin single states and the energy single state of the system all fall on the topological basis states. It is worth mentioning that for the closed 2N-qubit (N=2, 3, 4, ...) Heisenberg XXX spin chain, all the topological basis states for 2N particles are the spin single states of the system. And the number of the topological basis states is equal to the number of the spin single states of the system, which is \\frac{(2N)!}{N!(N+1)!} .

Pituitary tumor in a woman with a 47,XXX karyotype--case report.

PubMed

Witek, A; Skałba, P; Zieba, M

2001-01-01

The 47,XXX karyotype is a rare sex chromosome anomaly. This karyotype is usually not associated with a characteristic physical phenotype. In presented case a 47 triple X women with pituitary tumor and premature ovarian failure is identified. Diagnosis of a 47,XXX individual remains difficult because specific clinical criteria used to identify this condition are not available. The case described should attract attention to how difficult it is to diagnose properly a genetic disease in young women with correct phenotype.

[An XXX female with essential thrombocythemia].

PubMed

Ohta, Tadanobu; Hagiwara, Kioyuki; Makita, Kaori; Mugitani, Atuko; Ohta, Kensuke; Yamane, Takahisa; Takubo, Takayuki; Hino, Masayuki

2003-07-01

We describe an XXX female patient accompanied with essential thrombocythemia. To our knowledge this is the first case ever to have been reported. The patient was asymptomatic, but her platelet count had increased to 111.2 x 10(4)/microliter, and she was diagnosed as having essential thrombocythemia based on the diagnostic criteria of the Polycythemia Vera Study Group. At the same time, chromosome analysis of bone marrow cells revealed that she was an XXX female. The patient remained asymptomatic throughout the course of treatment.

Enamel Pit Defects and Taurodontism in a Patient with Ring Chromosome 14 and 47,XXX.

PubMed

Townsend, Janice A; Lacour, Letitia; Scheuerle, Angela E

2017-01-15

The purpose of this paper is to describe the clinical findings and management of a case involving a patient with co-occurring ring chromosome 14 syndrome and 47,XXX presenting with enamel pit defects and taurodontism. Ring chromosome 14 syndrome is an unusual condition with uncontrolled seizure disorder as its most significant finding; 47,XXX (trisomy X; triple X) is a more common condition and has characteristic physical and behavioral findings. Neither condition has been associated with enamel pit defects.

Status of Standardization Projects, Quarter Ending 30 June 1992

DTIC Science & Technology

1992-06-30

6505 5697 A-A-XXX AMINO ACIDS, INJECT MB ON F2 A 922 932 932 A MO MS 03 N 6505 5698 A-A-XXX SIMETHICONE TABS MB DM F4 A 922 932 932 A MD MS 03 N 6505...4 F2 A 922 932 932 A MD MS 03 N 5505 5698 A-A-XXX SIMETHICONE TABS MB 094 F4 A 922 932 932 A MD MS 03 N 5505 5699 U-N-210A SIMETHCONE TABS MB 09 H5

78 FR 55067 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-09

... OMB Number: Department of Navy Local Population Access Registration Form; MC-XXX; OMB Control Number... Registration Form, MC-XXX records the personal identifiable information that is used at the time of...

19 CFR 142.3a - Entry numbers.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) Format. The following format, including hyphens, must be used when showing the entry number: XXX-NNNNNNN-N XXX represents an entry filer code assigned by CBP, NNNNNNN is a unique number which is assigned...

19 CFR 142.3a - Entry numbers.

Code of Federal Regulations, 2014 CFR

2014-04-01

...) Format. The following format, including hyphens, must be used when showing the entry number: XXX-NNNNNNN-N XXX represents an entry filer code assigned by CBP, NNNNNNN is a unique number which is assigned...

19 CFR 142.3a - Entry numbers.

Code of Federal Regulations, 2011 CFR

2011-04-01

...) Format. The following format, including hyphens, must be used when showing the entry number: XXX-NNNNNNN-N XXX represents an entry filer code assigned by CBP, NNNNNNN is a unique number which is assigned...

19 CFR 142.3a - Entry numbers.

Code of Federal Regulations, 2012 CFR

2012-04-01

...) Format. The following format, including hyphens, must be used when showing the entry number: XXX-NNNNNNN-N XXX represents an entry filer code assigned by CBP, NNNNNNN is a unique number which is assigned...

19 CFR 142.3a - Entry numbers.

Code of Federal Regulations, 2010 CFR

2010-04-01

...) Format. The following format, including hyphens, must be used when showing the entry number: XXX-NNNNNNN-N XXX represents an entry filer code assigned by CBP, NNNNNNN is a unique number which is assigned...

Fertility in 47,XXX and 45,X patients.

PubMed Central

Dewhurst, J

1978-01-01

Female patients with a sex chromosome abnormality may be fertile. In patients with a 47,XXX cell line there appears to be an increased risk of a cytogenetically abnormal child but the extent of this risk cannot yet be determined; it is probably lower in the non-mosaic 47,XXX patient than the mosaic 46,XX/47,XXX one. Patients with a 45,X cell line rarly become pregnant, and when they do they appear to have a high risk of an abnormal child or repeated unsuccessfuly pregnancies; this risk is certainly exaggerated by the method of reporting; when the poor reproductive perforamcne is first identified leading to the recognition of the maternal cytogenetic fault, the reproductive failure rate is naturally high; when the maternal fault is first identified and the reproductive history then established far better results are evident. PMID:641947

An XXX male resulting from paternal X-Y interchange and maternal X-X nondisjunction.

PubMed Central

Annerén, G; Andersson, M; Page, D C; Brown, L G; Berg, M; Läckgren, G; Gustavson, K H; de la Chapelle, A

1987-01-01

A 2-year-old boy was found to have a 47,XXX karyotype. Restriction-fragment-length-polymorphism analysis showed that, of his three X chromosomes, one is of paternal and two are of maternal origin. The results of Y-DNA hybridization were reminiscent of those in XX males in two respects. First, hybridization to Southern transfers revealed the presence in this XXX male of sequences derived from the Y-chromosomal short arm. Second, in situ hybridization showed that this Y DNA was located on the tip of the X-chromosomal short arm. We conclude that this XXX male resulted from the coincidence of X-X nondisjunction during maternal meiosis and aberrant X-Y interchange either during or prior to paternal meiosis. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 PMID:2889356

PCT theorem for fields with arbitrary high-energy behavior

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luecke, W.

1986-07-01

A neutral scalar field A(x) is considered that has to be smeared by Fourier transforms of C/sup infinity/ functions with compact support but otherwise fulfills all the Wightman axioms, except strict local commutativity. It is shown to fulfill the PCT symmetry condition (where ..cap omega.. denotes the vacuum state vector) <..cap omega..Vertical BarA(x/sub 1/) xxx A(x/sub n/)..cap omega..> = <..cap omega..Vertical BarA(-x/sub n/) xxx A(-x/sub 1/)..cap omega..> if and only if <..cap omega..Vertical BarA(x/sub 1/) xxx A(x/sub n/)..cap omega..> -<..cap omega..Vertical BarA(x/sub n/) xxx A(x/sub 1/)..cap omega..> can be represented, in a sense, as an infinite sum of derivatives ofmore » measures with supports containing no Jost points.« less

Root length in the permanent teeth of women with an additional X chromosome (47,XXX females).

PubMed

Lähdesmäki, Raija E; Alvesalo, Lassi J

2010-07-01

Previous studies have demonstrated differential effects of the X and Y chromosomes on dental development. The expression of sexual dimorphism in terms of tooth size, shape, number and developmental timing has been explained especially by Y chromosome influence. The Y chromosome promotes enamel, crown and root dentin development. The X chromosome has an effect on enamel deposition. The aim of this research is to study the influence of the extra X chromosome on the development of permanent tooth root length. The study subjects (all of whom were from the Kvantti Dental Research Project) were seven 47,XXX females, five female relatives and 51 and 52 population control men and women, respectively. Measurements were made from panoramic radiographs on available permanent teeth by a digital calliper according to established procedures. The results showed that the maxillary root lengths of the 47,XXX females were of the same magnitude as those in normal women, but the mandibular root lengths were longer in 47,XXX females than in normal men or women. Increased enamel thickness in the teeth of 47,XXX females is apparently caused by the active enamel gene in all X chromosomes having no increased influence on crown dentin formation. These results in 47,XXX females indicate an increase in root dentin development, at least in the mandible, which together with the data on crown formation reflects a continuous long-lasting effect of the X chromosome on dental development.

Galectin-1-asialofetuin interaction is inhibited by peptides containing the tyr-xxx-tyr motif acting on the glycoprotein.

PubMed

Wéber, Edit; Hetényi, Anasztázia; Váczi, Balázs; Szolnoki, Eva; Fajka-Boja, Roberta; Tubak, Vilmos; Monostori, Eva; Martinek, Tamás A

2010-01-25

Galectin-1 (Gal-1), a ubiquitous beta-galactoside-binding protein expressed by various normal and pathological tissues, has been implicated in cancer and autoimmune/inflammatory diseases in consequence of its regulatory role in adhesion, cell viability, proliferation, and angiogenesis. The functions of Gal-1 depend on its affinity for beta-galactoside-containing glycoconjugates; accordingly, the inhibition of sugar binding blocks its functions, hence promising potential therapeutic tools. The Tyr-Xxx-Tyr peptide motifs have been reported to be glycomimetic sequences, mainly on the basis of their inhibitory effect on the Gal-1-asialofetuin (ASF) interaction. However, the results regarding the efficacy of the Tyr-Xxx-Tyr motif as a glycomimetic inhibitor are still controversial. The present STD and trNOE NMR experiments reveal that the Tyr-Xxx-Tyr peptides studied do not bind to Gal-1, whereas their binding to ASF is clearly detected. (15)N,(1)H HSQC titrations with (15)N-labeled Gal-1 confirm the absence of any peptide-Gal-1 interaction. These data indicate that the Tyr-Xxx-Tyr peptides tested in this work are not glycomimetics as they interact with ASF via an unrevealed molecular linkage.

50 CFR Table 13 to Part 679 - Transfer Form Summary

Code of Federal Regulations, 2013 CFR

2013-10-01

... sablefish, IFQ halibut, or CDQ halibut Transfer of product XXX Registered Buyer IFQ sablefish, IFQ halibut... site to processor. XXX indicates receipt must be issued to each receiver in a dockside sale. XXXX...

11 CFR 110.11 - Communications; advertising; disclaimers (2 U.S.C 441d).

Code of Federal Regulations, 2013 CFR

2013-01-01

... broadcast, cable, or satellite transmission, must include the following audio statement, “XXX is responsible... “XXX is responsible” statement; and (ii) A communication transmitted through television, or through any...

11 CFR 110.11 - Communications; advertising; disclaimers (2 U.S.C 441d).

Code of Federal Regulations, 2012 CFR

2012-01-01

... broadcast, cable, or satellite transmission, must include the following audio statement, “XXX is responsible... “XXX is responsible” statement; and (ii) A communication transmitted through television, or through any...

50 CFR Table 13 to Part 679 - Transfer Form Summary

Code of Federal Regulations, 2014 CFR

2014-10-01

... sablefish, IFQ halibut, or CDQ halibut Transfer of product XXX Registered Buyer IFQ sablefish, IFQ halibut... site to processor. XXX indicates receipt must be issued to each receiver in a dockside sale. XXXX...

26 CFR 1.3-1 - Application of optional tax.

Code of Federal Regulations, 2012 CFR

2012-04-01

.... Tables XVI through XXX apply for taxable years beginning after December 31, 1970. The standard deduction... deduction for Tables XVI through XXX, applicable to taxable years beginning in 1971, is 13 percent. For an...

11 CFR 110.11 - Communications; advertising; disclaimers (2 U.S.C 441d).

Code of Federal Regulations, 2014 CFR

2014-01-01

... broadcast, cable, or satellite transmission, must include the following audio statement, “XXX is responsible... “XXX is responsible” statement; and (ii) A communication transmitted through television, or through any...

26 CFR 1.3-1 - Application of optional tax.

Code of Federal Regulations, 2011 CFR

2011-04-01

.... Tables XVI through XXX apply for taxable years beginning after December 31, 1970. The standard deduction... deduction for Tables XVI through XXX, applicable to taxable years beginning in 1971, is 13 percent. For an...

26 CFR 1.3-1 - Application of optional tax.

Code of Federal Regulations, 2013 CFR

2013-04-01

.... Tables XVI through XXX apply for taxable years beginning after December 31, 1970. The standard deduction... deduction for Tables XVI through XXX, applicable to taxable years beginning in 1971, is 13 percent. For an...

50 CFR Table 13 to Part 679 - Transfer Form Summary

Code of Federal Regulations, 2012 CFR

2012-10-01

... sablefish, IFQ halibut, or CDQ halibut Transfer of product XXX Registered Buyer IFQ sablefish, IFQ halibut... site to processor. XXX indicates receipt must be issued to each receiver in a dockside sale. XXXX...

26 CFR 1.3-1 - Application of optional tax.

Code of Federal Regulations, 2014 CFR

2014-04-01

.... Tables XVI through XXX apply for taxable years beginning after December 31, 1970. The standard deduction... deduction for Tables XVI through XXX, applicable to taxable years beginning in 1971, is 13 percent. For an...

50 CFR Table 13 to Part 679 - Transfer Form Summary

Code of Federal Regulations, 2011 CFR

2011-10-01

... sablefish, IFQ halibut, or CDQ halibut Transfer of product XXX Registered Buyer IFQ sablefish, IFQ halibut... site to processor. XXX indicates receipt must be issued to each receiver in a dockside sale. XXXX...

75 FR 22745 - Procurement List Additions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-30

... Physical Fitness Uniform, Shirts X Small to XXX Large NSN: 8465-00-NIB-0189--United States Coast Guard... XXX Large NSN: 8465-00-NIB-0196--United States Coast Guard Trunks XSmall NSN: 8465-00-NIB-0197--United...

50 CFR Table 13 to Part 679 - Transfer Form Summary

Code of Federal Regulations, 2010 CFR

2010-10-01

... sablefish, IFQ halibut, or CDQ halibut Transfer of product XXX Registered Buyer IFQ sablefish, IFQ halibut... site to processor. XXX indicates receipt must be issued to each receiver in a dockside sale. XXXX...

26 CFR 1.3-1 - Application of optional tax.

Code of Federal Regulations, 2010 CFR

2010-04-01

.... Tables XVI through XXX apply for taxable years beginning after December 31, 1970. The standard deduction... deduction for Tables XVI through XXX, applicable to taxable years beginning in 1971, is 13 percent. For an...

78 FR 28895 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-16

... thanking Amy Reagan for her service on the Pro Bono Task Force (Resolution 2013-XXX) 4. Consider and act on... Corporate Secretary (Resolution 2013-XXX) 7. Public comment 8. Consider and act on other business 9...

The General Aviation Dynamics Model Volume III. Systems Manual.

DTIC Science & Technology

1979-07-01

SEXi and SEX2 or in some other way, as desired by the user. The descriptors of an index are used as stubs (row descriptors) and/or spanners (column...BAR A produces the following plot [7 SUWPLO~TS DATASET A, 1970 TO 1975 8+ .QL xx YXXMX 4+ MXUXX IDLMXX XXXXXX * yyx :mx0(c XXX *m XXXX XX XXXXX XMxK...VXXXCK 2+ mm~ XXXXX MMXXX I~CUM LXXMXx *X2~ XXX xXX =uXX ImXXXLMX * xx Iac lxxno IXxc= )LccIQX * XX= )LXXX ILMKXX X.XXXX IXXCX SHOW

Cu(II) Binding to the Peptide Ala-His-His, a Chimera of the Canonical Cu(II)-Binding Motifs Xxx-His and Xxx-Zzz-His.

PubMed

Gonzalez, Paulina; Vileno, Bertrand; Bossak, Karolina; El Khoury, Youssef; Hellwig, Petra; Bal, Wojciech; Hureau, Christelle; Faller, Peter

2017-12-18

Peptides and proteins with the N-terminal motifs NH 2 -Xxx-His and NH 2 -Xxx-Zzz-His form well-established Cu(II) complexes. The canonical peptides are Gly-His-Lys and Asp-Ala-His-Lys (from the wound healing factor and human serum albumin, respectively). Cu(II) is bound to NH 2 -Xxx-His via three nitrogens from the peptide and an external ligand in the equatorial plane (called 3N form here). In contrast, Cu(II) is bound to NH 2 -Xxx-Zzz-His via four nitrogens from the peptide in the equatorial plane (called 4N form here). These two motifs are not mutually exclusive, as the peptides with the sequence NH 2 -Xxx-His-His contain both of them. However, this chimera has never been fully explored. In this work, we use a multispectroscopic approach to analyze the Cu(II) binding to the chimeric peptide Ala-His-His (AHH). AHH is capable of forming the 3N- and 4N-type complexes in a pH dependent manner. The 3N form predominates at pH ∼ 4-6.5 and the 4N form at ∼ pH 6.5-10. NMR experiments showed that at pH 8.5, where Cu(II) is almost exclusively bound in the 4N form, the Cu(II)-exchange between AHH or the amidated AHH-NH 2 is fast, in comparison to the nonchimeric 4N form (AAH). Together, the results show that the chimeric AHH can access both Cu(II) coordination types, that minor changes in the second (or further) coordination sphere can impact considerably the equilibrium between the forms, and that Cu kinetic exchange is fast even when Cu-AHH is mainly in the 4N form.

21 CFR 177.1350 - Ethylene-vinyl acetate copolymers.

Code of Federal Regulations, 2014 CFR

2014-04-01

...) Substances identified in § 175.300(b)(3) (xxv), (xxvii), (xxx), and (xxxiii) of this chapter, and colorants... § 175.300(b)(3)(xxv), (xxvii), (xxxiii), and (xxx) of this chapter and colorants for polymers used in...

21 CFR 177.1350 - Ethylene-vinyl acetate copolymers.

Code of Federal Regulations, 2013 CFR

2013-04-01

...), (xxvii), (xxx), and (xxxiii) of this chapter, and colorants used in accordance with § 178.3297 of this... (xxx) of this chapter and colorants for polymers used in accordance with the provisions of § 178.3297...

21 CFR 177.1350 - Ethylene-vinyl acetate copolymers.

Code of Federal Regulations, 2011 CFR

2011-04-01

...), (xxvii), (xxx), and (xxxiii) of this chapter, and colorants used in accordance with § 178.3297 of this... (xxx) of this chapter and colorants for polymers used in accordance with the provisions of § 178.3297...

21 CFR 177.1350 - Ethylene-vinyl acetate copolymers.

Code of Federal Regulations, 2012 CFR

2012-04-01

...), (xxvii), (xxx), and (xxxiii) of this chapter, and colorants used in accordance with § 178.3297 of this... (xxx) of this chapter and colorants for polymers used in accordance with the provisions of § 178.3297...

Kabuki syndrome in a girl with mosaic 45,X/47,XXX and aortic coarctation.

PubMed

Chen, Chih-Ping; Lin, Shuan-Pei; Tsai, Fuu-Jen; Chern, Schu-Rern; Wang, Wayseen

2008-06-01

To describe the clinical findings of a patient with mosaic 45,X/47,XXX and aortic coarctation. Descriptive case study. Tertiary medical center. A 6-year-old girl with stigmata of Turner syndrome, aortic coarctation, patent ductus arteriosus, and a peculiar facial appearance. None. Cytogenetic analysis. The patient manifested a characteristic Kabuki syndrome facial appearance with long palpebral fissures, everted lateral third of lower eyelids, arched eyebrows, a depressed nasal tip, large dysplastic ears and epicanthic folds. She had undergone cardiac surgery for treatment of aortic coarctation and patent ductus arteriosus. Cytogenetic analysis of the blood lymphocytes revealed a karyotype of mos 45,X,9ph [35 cells]/47,XXX,9ph [5 cells]. This is the first report of mosaic 45,X/47,XXX associated with Kabuki syndrome. We emphasize that Kabuki syndrome, a peculiar facial appearance and aortic coarctation, should be considered in girls with sex chromosome abnormalities.

First report of a patient with a mixoploidy 47,XXX/94,XXXXXX.

PubMed

Rodríguez Criado, G; Galán Gómez, E; Tizzano, E F; García Rodríguez, E; Gómez de Terreros, I

2007-01-01

We present a 16 years old female with a chromosomal mixoploidy and multiple phenotypic anomalies. Peripheral blood G-band karyotype was 47,XXX and her skin fibroblast karyotype revealed a mosaic with a 47,XXX cell line in 88% of metaphases and a 94,XXXXXX cell line in 12% of metaphases, consistent with a hypertetraploidy. The most prominent clinical signs were: short stature, left upper limb asymmetry, senile-like appearance, generalized hypertrichosis, and small hands and feet. Radiological examination showed bone dysplasia. The result of molecular studies demonstrated that the patient inherited the two X chromosomes from the mother and one from the father, indicating that her 47,XXX trisomy resulted from an oogenesis error in the first meiotic division. The 94,XXXXXX cell line was likely the result of a cytokinesis error. To our knowledge, this is the first documented patient with a trisomy and a hypertetraploidy.

26 CFR 1.897-5T - Corporate distributions (temporary).

Code of Federal Regulations, 2014 CFR

2014-04-01

... provided in section 897 and the regulations thereunder, except as provided by Articles XIII (9) and XXX (5... June 6, 1988. With regard to Article XXX (5) of the Income Tax Treaty with Canada, see, Rev. Rul. 85-76...

26 CFR 1.897-5T - Corporate distributions (temporary).

Code of Federal Regulations, 2011 CFR

2011-04-01

... provided in section 897 and the regulations thereunder, except as provided by Articles XIII (9) and XXX (5... June 6, 1988. With regard to Article XXX (5) of the Income Tax Treaty with Canada, see, Rev. Rul. 85-76...

26 CFR 1.897-5T - Corporate distributions (temporary).

Code of Federal Regulations, 2012 CFR

2012-04-01

... provided in section 897 and the regulations thereunder, except as provided by Articles XIII (9) and XXX (5... June 6, 1988. With regard to Article XXX (5) of the Income Tax Treaty with Canada, see, Rev. Rul. 85-76...

26 CFR 1.897-5T - Corporate distributions (temporary).

Code of Federal Regulations, 2013 CFR

2013-04-01

... provided in section 897 and the regulations thereunder, except as provided by Articles XIII (9) and XXX (5... June 6, 1988. With regard to Article XXX (5) of the Income Tax Treaty with Canada, see, Rev. Rul. 85-76...

75 FR 10223 - Procurement List Proposed Additions and Deletions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-05

... Uniform, T-Shirts X Small to XXX Large NSN: 8465-00-NIB-0189--XSmall NSN: 8465-00-NIB-0190--Small NSN..., AR Coast Guard Physical Fitness Uniform, Trunks X Small to XXX Large NSN: 8465-00-NIB-0196--XSmall...

26 CFR 1.897-5T - Corporate distributions (temporary).

Code of Federal Regulations, 2010 CFR

2010-04-01

... provided in section 897 and the regulations thereunder, except as provided by Articles XIII (9) and XXX (5... June 6, 1988. With regard to Article XXX (5) of the Income Tax Treaty with Canada, see, Rev. Rul. 85-76...

Potent μ-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[D-Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation.

PubMed

Li, Yangmei; Cazares, Margret; Wu, Jinhua; Houghten, Richard A; Toll, Laurence; Dooley, Colette

2016-02-11

To optimize the structure of a μ-opioid receptor ligand, analogs H-Tyr-c[D-Lys-Xxx-Tyr-Gly] were synthesized and their biological activity was tested. The analog containing a Phe(3) was identified as not only exhibiting binding affinity 14-fold higher than the original hit but also producing agonist activity 3-fold more potent than morphine. NMR study suggested that a trans conformation at D-Lys(2)-Xxx(3) is crucial for these cyclic peptides to maintain high affinity, selectivity, and functional activity toward the μ-opioid receptor.

Galanin: A Role in Mesolimbic Dopamine-Mediated Instrumental Behavior?

PubMed Central

Robinson, John K.; Brewer, Ariel

2008-01-01

ROBINSON, J.K. and Brewer, A. Galanin: A Role in Mesolimbic-Dopamine Mediated Instrumental Behavior? NEUROSCI BIOBEHAV REV XX(X) XXX-XXX, 2008. The involvement of the neuropeptide galanin in the consumption of the primary “commodities” of food and water is well established. However, the present review describes anatomical and behavioral evidence that suggests that galanin may also modulate ascending mesolimbic dopamine function and thereby play an inhibitory role in the systems by which instrumental behavior is energized toward acquiring primary commodities. General anatomical frameworks for this interaction are presented and future studies that could evaluate it are discussed. PMID:18632153

Transition from adolescence to early adulthood: adaptation and psychiatric status of women with 47,XXX.

PubMed

Harmon, R J; Bender, B G; Linden, M G; Robinson, A

1998-03-01

To investigate the adolescent and early adult adaptation of a group of 47,XXX women as compared with their siblings, addressing developmental differences in adaptation and psychiatric status. Subjects included eleven 47,XXX women and nine female sibling controls. Interviews during adolescence and during early adulthood were semistructured and included a psychiatric evaluation. Four areas of inquiry were (1) relationships with other family members, (2) sense of self-esteem, (3) sexual identity and preference, and (4) responses to life stressors. A DSM-IV psychiatric diagnosis was assigned where appropriate. The Schedule for Affective Disorders and Schizophrenia-Lifetime version was also administered, and assessments of overall functioning and adaptation were completed. The 47,XXX women during adolescence and young adulthood were less well adapted; had more stress; had more work, leisure, and relationship problems; had a lower IQ; and showed more psychopathology when contrasted with the comparison group. However, most of the 47,XXX women were self-sufficient and functioning reasonably well, albeit less well than their siblings. This longitudinal study has clarified that previously reported outcomes of severe psychopathology and antisocial behavior in individuals with sex chromosome anomalies are rare and variability in the behavioral phenotype is much larger than originally appreciated.

N-Terminal Cu-Binding Motifs (Xxx-Zzz-His, Xxx-His) and Their Derivatives: Chemistry, Biology and Medicinal Applications.

PubMed

Gonzalez, Paulina; Bossak, Karolina; Stefaniak, Ewelina; Hureau, Christelle; Raibaut, Laurent; Bal, Wojciech; Faller, Peter

2018-06-07

Peptides and proteins with N-terminal amino acid sequences NH 2 -Xxx-His (XH) and NH 2 -Xxx-Zzz-His (XZH) form well-established high-affinity Cu II -complexes. Key examples are Asp-Ala-His (in serum albumin) and Gly-His-Lys, the wound healing factor. This opens a straightforward way to add a high-affinity Cu II -binding site to almost any peptide or protein, by chemical or recombinant approaches. Thus, these motifs, NH 2 -Xxx-Zzz-His in particular, have been used to equip peptides and proteins with a multitude of functions based on the redox activity of Cu, including nuclease, protease, glycosidase, or oxygen activation properties, useful in anticancer or antimicrobial drugs. More recent research suggests novel biological functions, mainly based on the redox inertness of Cu II in XZH, like PET imaging (with 64 Cu), chelation therapies (for instance in Alzheimer's disease and other types of neurodegeneration), antioxidant units, Cu transporters and activation of biological functions by strong Cu II binding. This Review gives an overview of the chemical properties of Cu-XH and -XZH motifs and discusses the pros and cons of the vastly different biological applications, and how they could be improved depending on the application. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Theoretical study of the interaction of N/sub 2/ with water molecules. (H/sub 2/O)/sub n/:N/sub 2/, n = 1--8

DOE Office of Scientific and Technical Information (OSTI.GOV)

Curtiss, L.A.; Eisgruber, C.L.

1984-03-01

Ab initio molecular orbital calculations including correlation energy have been carried out on the interaction of a single H/sub 2/O molecule with N/sub 2/. The potential energy surface for H/sub 2/O:N/sub 2/ is found to have a minimum corresponding to a HOH xxx N/sub 2/ structure with a weak (<2 kcal mol/sup -1/) hydrogen bond. A second, less stable, configuration corresponding to a H/sub 2/O xxx N/sub 2/ structure with N/sub 2/ bonded side on to the oxygen of H/sub 2/O was found to be either a minimum or a saddle point in the potential energy surface depending on themore » level of calculation. The minimal STO-3G basis set was used to investigate the interaction of up to eight H/sub 2/O molecules with N/sub 2/. Two types of clusters, one containing only HOH xxx N/sub 2/ interactions and the other containing both HOH xxxN/sub 2/ and H/sub 2/O xxx N/sub 2/ interactions, were investigated for (N/sub 2/:(H/sub 2/O)/sub n/, n = 2--8).« less

15 CFR 752.10 - Changes to the SCL.

Code of Federal Regulations, 2014 CFR

2014-01-01

... request for each end-user. Example: end-user XXX is to be “added” and end-user AAA is to be “changed” from... Blocks 1 and 19. In Block 21, cite the end-user requirement or condition (i.e., end-user XXX is requested...

17 CFR Appendix A to Part 165 - Guidance With Respect to the Protection of Whistleblowers Against Retaliation

Code of Federal Regulations, 2012 CFR

2012-04-01

... XXXXX.gov; or by facsimile to (202) XXX-XXXX. • The whistleblower has the right to submit information... Street, NW., Washington, DC 20581; or ○ By faxing the signed form to (202) XXX-XXXX. Instructions for...

17 CFR Appendix A to Part 165 - Guidance With Respect to the Protection of Whistleblowers Against Retaliation

Code of Federal Regulations, 2013 CFR

2013-04-01

... XXXXX.gov; or by facsimile to (202) XXX-XXXX. • The whistleblower has the right to submit information... Street, NW., Washington, DC 20581; or ○ By faxing the signed form to (202) XXX-XXXX. Instructions for...

17 CFR Appendix A to Part 165 - Guidance With Respect to the Protection of Whistleblowers Against Retaliation

Code of Federal Regulations, 2014 CFR

2014-04-01

... XXXXX.gov; or by facsimile to (202) XXX-XXXX. • The whistleblower has the right to submit information... Street, NW., Washington, DC 20581; or ○ By faxing the signed form to (202) XXX-XXXX. Instructions for...

15 CFR 752.10 - Changes to the SCL.

Code of Federal Regulations, 2012 CFR

2012-01-01

... request for each end-user. Example: end-user XXX is to be “added” and end-user AAA is to be “changed” from... Blocks 1 and 19. In Block 21, cite the end-user requirement or condition (i.e., end-user XXX is requested...

15 CFR 752.10 - Changes to the SCL.

Code of Federal Regulations, 2013 CFR

2013-01-01

... request for each end-user. Example: end-user XXX is to be “added” and end-user AAA is to be “changed” from... Blocks 1 and 19. In Block 21, cite the end-user requirement or condition (i.e., end-user XXX is requested...

15 CFR 752.10 - Changes to the SCL.

Code of Federal Regulations, 2011 CFR

2011-01-01

... request for each end-user. Example: end-user XXX is to be “added” and end-user AAA is to be “changed” from... Blocks 1 and 19. In Block 21, cite the end-user requirement or condition (i.e., end-user XXX is requested...

Prenatal diagnosis of 47,XXX.

PubMed

Khoury-Collado, Fady; Wehbeh, Ammar N; Fisher, Allan J; Bombard, Allan T; Weiner, Zeev

2005-05-01

We report 2 cases of 47,XXX that were diagnosed prenatally and were screened positive for trisomy 21 by biochemical and ultrasound markers. These cases underline the importance of discussing the sex chromosome abnormalities during the genetic counseling after an abnormal triple screen test or ultrasound examination.

15 CFR 752.10 - Changes to the SCL.

Code of Federal Regulations, 2010 CFR

2010-01-01

... request for each end-user. Example: end-user XXX is to be “added” and end-user AAA is to be “changed” from... Blocks 1 and 19. In Block 21, cite the end-user requirement or condition (i.e., end-user XXX is requested...

PREFACE: XXX International Conference on Interaction of Intense Energy Fluxes with Matter

NASA Astrophysics Data System (ADS)

Fortov, V. E.; Khishchenko, K. V.; Karamurzov, B. S.; Efremov, V. P.; Sultanov, V. G.

2015-11-01

This paper is a preface to the proceedings of the XXX International Conference on Interaction of Intense Energy Fluxes with Matter, which was held in Elbrus settlement, in the Kabardino-Balkar Republic of the Russian Federation, from March 1-6, 2015.

Fatigue Resistance of Al-Cu-Li and Comparison with 7xxx Aerospace Alloys

NASA Astrophysics Data System (ADS)

Daniélou, A.; Ronxin, J. P.; Nardin, C.; Ehrström, J. C.

Al-Cu-Li alloys are of great interest for aerospace applications due to their good mechanical property balance, excellent corrosion resistance and reduced density. These alloys exhibit an increased resistance to fatigue in particular when compared to 7xxx alloys.

NASA-UVa light aerospace alloy and structure technology program supplement: Aluminum-based materials for high speed aircraft

NASA Technical Reports Server (NTRS)

Starke, E. A., Jr.

1993-01-01

This report on the NASA-UVa Light Aerospace Alloy and Structure Technology Program Supplement: Aluminum-Based Materials for High Speed Aircraft covers the period from January 1, 1992 to June 30, 1992. The objective of the research is to develop aluminum alloys and aluminum matrix composites for the airframe which can efficiently perform in the HSCT environment for periods as long as 60,000 hours (certification for 120,000 hours) and, at the same time, meet the cost and weight requirements for an economically viable aircraft. Current industry baselines focus on flight at Mach 2.4. The research covers four major materials systems: (1) ingot metallurgy 2XXX, 6XXX, and 8XXX alloys, (2) powder metallurgy 2XXX alloys, (3) rapidly solidified, dispersion strengthened Al-Fe-X alloys, and (4) discontinuously reinforced metal matrix composites. There are ten major tasks in the program which also include evaluation and trade-off studies by Boeing and Douglas aircraft companies.

NASA-UVa light aerospace alloy and structures technology program supplement: Aluminum-based materials for high speed aircraft

NASA Technical Reports Server (NTRS)

Starke, E. A., Jr. (Editor)

1995-01-01

This report on the NASA-UVa light aerospace alloy and structure technology program supplement: Aluminum-Based Materials for High Speed Aircraft covers the period from July 1, 1992. The objective of the research is to develop aluminum alloys and aluminum matrix composites for the airframe which can efficiently perform in the HSCT environment for periods as long as 60,000 hours (certification for 120,000 hours) and, at the same time, meet the cost and weight requirements for an economically viable aircraft. Current industry baselines focus on flight at Mach 2.4. The research covers four major materials systems: (1) Ingot metallurgy 2XXX, 6XXX, and 8XXX alloys, (2) Powder metallurgy 2XXX alloys, (3) Rapidly solidified, dispersion strengthened Al-Fe-X alloys, and (4) Discontinuously reinforced metal matrix composites. There are ten major tasks in the program which also include evaluation and trade-off studies by Boeing and Douglas aircraft companies.

26 CFR 1.897-6T - Nonrecognition exchanges applicable to corporations, their shareholders, and other taxpayers, and...

Code of Federal Regulations, 2013 CFR

2013-04-01

... section 897 and the regulations thereunder, except as provided by Articles XII (9) and XXX (5) of the... regard to Article XXX (5) the Income Tax Treaty with Canada, see, Rev. Rul. 85-76, 1985-1 C.B. 409. (b...

26 CFR 1.897-6T - Nonrecognition exchanges applicable to corporations, their shareholders, and other taxpayers, and...

Code of Federal Regulations, 2012 CFR

2012-04-01

... section 897 and the regulations thereunder, except as provided by Articles XII (9) and XXX (5) of the... regard to Article XXX (5) the Income Tax Treaty with Canada, see, Rev. Rul. 85-76, 1985-1 C.B. 409. (b...

26 CFR 1.897-6T - Nonrecognition exchanges applicable to corporations, their shareholders, and other taxpayers, and...

Code of Federal Regulations, 2014 CFR

2014-04-01

... section 897 and the regulations thereunder, except as provided by Articles XII (9) and XXX (5) of the... regard to Article XXX (5) the Income Tax Treaty with Canada, see, Rev. Rul. 85-76, 1985-1 C.B. 409. (b...

78 FR 53452 - Notice Announcing Filing Priority for Preliminary Permit Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-29

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice Announcing Filing Priority for Preliminary Permit Applications Lock+ Hydro Friends Fund XXX, LLC.. Project No. 13625-003 FFP Project 121, LLC.... FFP Project 121, LLC Project No. 14504-000 2. Lock+ Hydro Friends Fund XXX, LLC Project No. 13625-003...

75 FR 53718 - Notice of Lodging of Consent Decree Under the Comprehensive Environmental Response, Compensation...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-01

... States v. International Paper Company, et al., Civil Action No. 10-cv-03749-ADM-XXX. In this action, the... Action No.10-cv-03749-ADM-XXX, DJ 90-11-3-06790/2. The Consent Decrees may be examined at the Office of...

Selected DOE headquarters publications

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1979-04-01

This publication provides listings of (mainly policy and programmatic) publications which have been issued by headquarters organizations of the Department of Energy; assigned a DOE/XXX- type report number code, where XXX is the 1- to 4-letter code for the issuing headquarters organization; received by the Energy Library; and made available to the public.

47,XXX in an adolescent with premature ovarian failure and autoimmune disease.

PubMed

Holland, C M

2001-05-01

Premature ovarian failure (POF) may be idiopathic or may be associated with genetic or autoimmune disorders. The 47,XXX karyotype has been associated with POF and other genitourinary anomalies. A 17-year-old woman with a history of immune thrombocytopenic purpura was referred to the adolescent medicine clinic for evaluation of oligomenorrhea with secondary amenorrhea. Evaluation revealed hypergonadotrophic premature ovarian failure, a positive antinuclear antibody, and the 47,XXX karyotype. She has since developed a positive anti-cardiolipin antibody but does not meet diagnostic criteria for systemic lupus erythematosis. The presence of known autoimmune disease in a woman with POF should not dissuade the clinician from evaluating for a potential genetic cause.

Status of Standardization Projects

DTIC Science & Technology

1993-03-31

XXX CABINET DOUGH PRF 18 PAN CAP GL B4 A 914 931 932 A GL YD 99 GS U B 7320 0875 A A XXX VEGETABLE CUT AND SL MACH GL B4 A 914 931 932 A GL YD 99 GS... DOUGH ROLLING MACHINES PIE YD H5 924 934 934 A YD 99 N 7320 0898 OO-D-2813 DOUGH ROLLING MACHINES PIE YD B4 924 934 934 A YO 99 N 7320 0899 A-A-50109...0903 A-A-XXX VEGETABLE PEELING MACHINE ELEC GL B4 A 931 934 934 A GL YD 99 GS N 7320 0904 MIL-D-13053D NOT 1 DOUGH TROUGHS GL H5 932 941 941 A GL YD 99

Autoimmune myelofibrosis accompanied by Sjögren's syndrome in a 47, XXX/46, XX mosaic woman.

PubMed

Takahashi, Tohru

2014-01-01

This report describes a patient with autoimmune myelofibrosis accompanied by Sjögren's syndrome (SS). A 36-year-old woman was admitted due to petechiae, purpura, gingival bleeding, dyspnea on exertion, and a lack of concentration. She had pancytopenia and was diagnosed with SS. A bone marrow study showed hypercellular marrow with reticulin fibrosis. Lymphocytic infiltrates and aggregates composed of a mixture of T and B cells in the marrow were also observed. A chromosomal analysis of the marrow cells showed 47, XXX and an analysis of peripheral lymphocytes revealed 47, XXX/46, XX mosaic results. The patient's cytopenia resolved following treatment with oral prednisolone.

Conditioned taste aversion, drugs of abuse and palatability

PubMed Central

Lin, Jian-You; Arthurs, Joe; Reilly, Steve

2014-01-01

LIN, J.-Y., J. Arthurs and S. Reilly. Conditioned taste aversion: Palatability and drugs of abuse. NEUROSCI BIOBEHAV REV XX(x) XXX-XXX, 2014. – We consider conditioned taste aversion to involve a learned reduction in the palatability of a taste (and hence in amount consumed) based on the association that develops when a taste experience is followed by gastrointestinal malaise. The present article evaluates the well-established finding that drugs of abuse, at doses that are otherwise considered rewarding and self-administered, cause intake suppression. Our recent work using lick pattern analysis shows that drugs of abuse also cause a palatability downshift and, therefore, support conditioned taste aversion learning. PMID:24813806

33 CFR 67.50-25 - Eighth Coast Guard District.

Code of Federal Regulations, 2012 CFR

2012-07-01

... point at latitude 27°49′.5 N., longitude 97°01′.2 W., thence to; (xxx) A point on the 10 fathom curve at... W., thence to; (xxx) A point at Lat. 29°44′.6 N., Long. 93°07′.9 W., thence to; (xxxi) A point at...

33 CFR 67.50-25 - Eighth Coast Guard District.

Code of Federal Regulations, 2011 CFR

2011-07-01

... point at latitude 27°49′.5 N., longitude 97°01′.2 W., thence to; (xxx) A point on the 10 fathom curve at... W., thence to; (xxx) A point at Lat. 29°44′.6 N., Long. 93°07′.9 W., thence to; (xxxi) A point at...

33 CFR 67.50-25 - Eighth Coast Guard District.

Code of Federal Regulations, 2013 CFR

2013-07-01

... point at latitude 27°49′.5 N., longitude 97°01′.2 W., thence to; (xxx) A point on the 10 fathom curve at... W., thence to; (xxx) A point at Lat. 29°44′.6 N., Long. 93°07′.9 W., thence to; (xxxi) A point at...

33 CFR 67.50-25 - Eighth Coast Guard District.

Code of Federal Regulations, 2014 CFR

2014-07-01

... point at latitude 27°49′.5 N., longitude 97°01′.2 W., thence to; (xxx) A point on the 10 fathom curve at... W., thence to; (xxx) A point at Lat. 29°44′.6 N., Long. 93°07′.9 W., thence to; (xxxi) A point at...

47,XXX/48,XXXX in a retarded three year old girl with multiple somatic anomalies.

PubMed

Ioan, D; Hîrşovescu, N; Dumitriu, L; Belengeanu, V; Muşeţeanu, P; Maximilian, C

1985-01-01

A 3-year old girl with 47,XXX/48,XXXX caryotype is presented. She suffers from psychomotor retardation, dolichocephaly, malformed ears, "a false air of trisomy 21", malformation of the legs, obesity. The authors discuss briefly the available data on the triplo and tetra X phenotype and syndromes.

Case report: a successful pregnancy outcome in a patient with non-mosaic Turner syndrome (45, X) via in vitro fertilization.

PubMed

Sugawara, Nobuo; Kimura, Yasuyuki; Araki, Yasuhisa

2013-03-01

We describe a successful pregnancy outcome in a patient with non-mosaic Turner syndrome (45, X) via in vitro fertilization. The patient achieved a second pregnancy at 35 years of age. The her blood lymphocyte karyotype was examined by G-band and FISH. Furthermore, cumulus cells and her elbow skin cells were evaluated via FISH. Non-mosaic Turner syndrome was determined by G-banding [100 % (50/50) 45, X]. Lymphocytes were shown as 478/500 (95.6 %) cells of X sex chromosome signal, 15/500 (3.0 %) cells of XXX signal, and 7/500 (1.4 %) cells of XX signal. The cumulus cells were mosaic: 152/260 (58.5 %) were X; 84/260 (32.3 %) were XXX, 20/260 (7.7 %) were XX, and 4/260 (1.5 %) were XY. Moreover, skin cells included a mosaic karyotype [47, XXX(29)/46, XX(1)]. We conclude that the collection of a large number of blood lymphocytes can reveal different mosaic patterns (X, XX and XXX) by FISH in spite of non-mosaic Turner syndrome.

Rare case of massive congenital bilateral chylothorax in a hydropic fetus with true mosaicism 47,XXX/46,XX.

PubMed

Cremonini, Giorgio; Poggi, Alice; Capucci, Roberta; Vesce, Fortunato; Patella, Alfredo; Marci, Roberto

2014-01-01

Fetal congenital chylothorax is a rare condition that occurs sporadically or can be associated with abnormal karyotype or structural chromosomal anomalies. We report a unique case of fetal congenital bilateral chylothorax associated with mosaicism 47,XXX/46,XX. A female fetus affected by massive bilateral hydrothorax and ascites was diagnosed at 34(+1) weeks of gestation. Previous ultrasonographic exams were completely normal. Immune causes of hydrops were excluded. Elective cesarean section was performed soon after bilateral thoracocentesis. The analysis of drained pleural fluid revealed its lymphatic nature. The fetal karyotyping, performed on chorionic villi at the 11th week, had shown mosaicism 47,XXX/46,XX, later confirmed in the newborn's blood. We hypothesized that chylothorax may be part of the phenotypic spectrum of 47 XXX karyotype and we suggest an ultrasound follow-up of the fetus at closer intervals than the routine timing for this condition, even if it is not usually characterized by severe phenotypic features. © 2013 The Authors. Journal of Obstetrics and Gynaecology Research © 2013 Japan Society of Obstetrics and Gynecology.

Reduced size of the amygdala in individuals with 47,XXY and 47,XXX karyotypes.

PubMed

Patwardhan, Anil J; Brown, Wendy E; Bender, Bruce G; Linden, Mary G; Eliez, Stephan; Reiss, Allan L

2002-01-08

The excess of 47,XXX and 47,XXY karyotypes found in cytogenetic screening studies of individuals with schizophrenia has given support for an increased risk of psychiatric illness among men and women with sex chromosomal aneuploidy (SCA). Mesial temporal lobe structures, including the amygdala and hippocampus, are thought to be associated with abnormalities of mood and behavior in humans and in the neurobiology of schizophrenia. This study focuses on variations in volumes of mesial temporal lobe structures in men and women with SCA. Utilizing an unselected birth cohort of subjects with SCA and high-resolution magnetic resonance imaging (MRI), we investigated the neuroanatomical consequences of a supernumerary X chromosome on the morphology of the amygdala and hippocampus. Regional and total brain volumes were measured in 10 subjects with 47,XXY, 10 subjects with 47,XXX, and 20 euploid controls. Amygdala volumes were significantly reduced in men with 47,XXY, compared to control men, while the decrease in women with 47,XXX was not as pronounced. Hippocampus volumes were preserved in both groups, compared to same-gender controls. Longitudinal studies of SCA individuals have shown an increased incidence of mild psychopathology and behavioral dysfunction in men with 47,XXY and more overt psychiatric illness in women with 47,XXX, compared to control populations. The alteration in amygdala volumes in individuals with a supernumerary X chromosome may provide a neuroanatomic basis for these findings. Copyright 2001 Wiley-Liss, Inc.

Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma.

PubMed

Pritchard-Jones, R O; Dunn, D B A; Qiu, Y; Varey, A H R; Orlando, A; Rigby, H; Harper, S J; Bates, D O

2007-07-16

Malignant melanoma is the most lethal of the skin cancers and the UK incidence is rising faster than that of any other cancer. Angiogenesis - the growth of new vessels from preexisting vasculature - is an absolute requirement for tumour survival and progression beyond a few hundred microns in diameter. We previously described a class of anti-angiogenic isoforms of VEGF, VEGF(xxx)b, that inhibit tumour growth in animal models, and are downregulated in some cancers, but have not been investigated in melanoma. To determine whether VEGF(xxx)b expression was altered in melanoma, PCR and immunohistochemistry of archived human tumour samples were used. In normal epidermis and in a proportion of melanoma samples, VEGF(xxx)b staining was seen. Some melanomas had much weaker staining. Subsequent examination revealed that expression was significantly reduced in primary melanoma samples (both horizontal and vertical growth phases) from patients who subsequently developed tumour metastasis compared with those who did not (analysis of variance (ANOVA) P<0.001 metastatic vs nonmetastatic), irrespective of tumour thickness, while the surrounding epidermis showed no difference in expression. Staining for total VEGF expression showed staining in metastatic and nonmetastatic melanomas, and normal epidermis. An absence of VEGF(xxx)b expression appears to predict metastatic spread in patients with primary melanoma. These results suggest that there is a switch in splicing as part of the metastatic process, from anti-angiogenic to pro-angiogenic VEGF isoforms. This may form part of a wider metastatic splicing phenotype.

A finding in genetic polymorphism analysis study: A case of non-mosaic 47, XXX without manifestations.

PubMed

Yang, Xingyi; Ye, Zilan; Zhang, Xiaofang; Wang, Huijun; Liu, Chao

2017-07-01

Trisomy X (47, XXX) is a sex chromosome aneuploidy condition in which females have an extra X chromosome, compared to the 46, XX karyotype in typical females. There is considerable variation in the phenotype, with some individuals very mildly affected and others with more significant physical and psychological features. However, the trisomy X in this case, without any of these phenotype, is rarely reported. Here, we report a case found during DNA sample collection in a study of genetic polymorphism analysis of loci in Chinese ethnic group, of a female with neither laboratory or clinical signs of Triple X syndrome. She was born at her mother's 60years old and her father's 62years old. Advanced maternal age was found acting as a significant risk factor of Triplo-X. Moreover, her child are also born without manifestations of 47, XXX syndrome. Pedigree study demonstrated the normal karyotype of the children. A diagnosis of 47XXX was made on the basis of a chromosomal study. Therefore, laboratory investigations (including PCR amplification, more than two kinds of X-STR genotyping, G-banding karyotyping analysis and Pedigree study) are applied to rule out the possibility of Mosaicism (45, X0/47, XXX) and ascertain her 47XXX karyotype without mosaic. The objective of this study was to report a case of trisomy X, diagnostic investigation and management of the case, and to analysis the genetically possible reasons behind the case. To our knowledge, this case is a rare one, found in DNA sample collection for the estimation of gene frequency in the process of genetic polymorphism study, of non-mosaic 47, XXX without signs of physical syndrome and born healthy children. In this study, it revealed that the proportion of trisomy X would be more than official statistics and risk of systemic disabilities is lower than estimated. Moreover, we found out that sample mixture and mosaicism act as the interference factors in forensic test. Therefore, we draw the conclusion that attentions and certain improved methods should be applied to the diagnosis of non-mosaic triple X, which is of great significance in decreasing the interruptions in the whole process of forensic and paternity identification. Copyright © 2017 Elsevier B.V. All rights reserved.

From quantum affine groups to the exact dynamical correlation function of the Heisenberg model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bougourzi, A.H.; Couture, M.; Kacir, M.

1997-01-20

The exact form factors of the Heisenberg models XXX and XXZ have been recently computed through the quantum affine symmetry of XXZ model in the thermodynamic limit. The authors use them to derive an exact formula for the contribution of two spinons to the dynamical correlation function of XXX model at zero temperature.

Surfactant-enhanced singlet energy transfer from the charge-transfer excited state of tris(2,2-bipyridine) ruthenium(II)

NASA Astrophysics Data System (ADS)

Mandal, Krishnagopal; Demas, J. N.

1981-12-01

Very efficient (45-75%) sodium lauryl sulfate (NaLS) enhanced singlet enengy transfer has been demonstrated from the spin-orbit charge-transfer excited state of [Ru(bpy) 3] 2+ (bpy = 2,2'-bipyridine) to the xxx violet, oxazine 1, and rhodamine 101 at concentrations of 10 -5 M, Energy transfer occurs in xxx.

78 FR 77699 - Information Collection Request Sent to the Office of Management and Budget (OMB) for Approval...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-24

... DEPARTMENT OF THE INTERIOR Fish and Wildlife Service [FWS-HQ-WSR-2013-N292]; [FVWF941009000007B-XXX-FF09W10000; FVWF51100900000-XXX-FF09W10000] Information Collection Request Sent to the Office of... technology constraints. We expanded to a cloud-computing environment in October 2012, and, effective January...

Ensuring the Continued Relevance of Long Range Surveillance Units

DTIC Science & Technology

2002-05-31

reconnaissance units (see figure 2). 18 XXX XXX XX XX Corps Area of OperationsDivision Area of Operations Corps FLOT Division FLOT Scouts, Recon Teams 0 LRSC...while a student in LRSLC stated: “You just can’t beat it. A lot of guys don’t like it because you don’t get an award for it. It’s not a sexy

Registration of CA0469C025C chickpea germplasm

USDA-ARS?s Scientific Manuscript database

Chickpea (Cicer arientinum L.) germplasm CA0469C025C (Reg. No. XXX; PI XXX), was released by the USDA-ARS in 2010. CA0469C025C was released based on its improved yield and reaction to Ascochyta blight relative to the popular commercial cultivars ‘Dwelley’, ‘Sierra’, and ‘Sawyer’. CA0490C025C is deri...

Registration of two confection sunflower germplasm Lines, HA-R10 and HA-R11, Resistant to sunflower rust

USDA-ARS?s Scientific Manuscript database

Two confection sunflower (Helianthus annuus L.) germplasm lines, HA-R10 (Reg. No.xxx, PI670043) and HA-R11 (Reg. No.xxx, PI670044) were developed by the USDA-ARS Sunflower and Plant Biology Research Unit in collaboration with the North Dakota Agricultural Experiment Station and released December, 20...

GnRH-dependent precocious puberty manifested at the age of 14 months in a girl with 47,XXX karyotype.

PubMed

Skordis, Nicos; Ferrari, Eleana; Antoniadou, Aria; Phylactou, Leonidas A; Fanis, Pavlos; Neocleous, Vassos

2017-07-01

This case report describes a 47,XXX girl who presented very early, at the age of 14 months, with signs of sexual precocity (breast and pubic hair development, menarche) and was finally diagnosed with GnRH dependent precocious puberty with no evidence of underlying central nervous system pathology. Molecular testing did not identify any genetic defect in any of the genes tested (KISS1, KISS1R, DLK1 and the intronless MKRN3). Though previous studies have shown a link between karyotype 47,XXX and precocious puberty, this is the youngest patient reported so far. Treatment with GnRH analog was commenced and proved to be effective, indicating a successful suppression of the hypothalamic-pituitary-ovarian axis.

Long survival in a 69,XXX triploid infant in Greece.

PubMed

Iliopoulos, Dimitrios; Vassiliou, Georgia; Sekerli, Eleni; Sidiropoulou, Vasiliki; Tsiga, Alexandra; Dimopoulou, Despina; Voyiatzis, Nikolaos

2005-12-30

The live birth of a triploidy infant is a very rare event and death usually occurs within the first hours of life. Triploid cases with a survival of more than two months are infrequent. We report on an infant with a 69,XXX chromosome constitution who survived 164 days. Chromosomal analysis demonstrated a 69,XXX karyotype with no evidence of mosaicism. This is the longest survival reported for this condition to date in Greece and the fourth longest worldwide. The infant was admitted to our clinic several times due to respiratory problems, and supplementary oxygen was required. The improved survival of our case was possibly due to better management of respiratory illness and prematurity, and these are essential factors that physicians should consider carefully with such rare cases.

Turner's syndrome and pregnancy: has the 45,X/47,XXX mosaicism a different prognosis? Own clinical experience and literature review.

PubMed

Bouchlariotou, Sofia; Tsikouras, Panagiotis; Dimitraki, Marina; Athanasiadis, Apostolos; Papoulidis, Ioannis; Maroulis, George; Liberis, Anastasios; Liberis, Vasileios

2011-05-01

Turner's syndrome is characterized by an ovarian failure which occurs in most cases before puberty and leads to infertility. In less than 10% of women with Turner syndrome, puberty may occur and spontaneous pregnancies is possible but with a high risk of fetal loss, chromosomal and congenital abnormalities. We present the case of a 33-year-old woman with a mosaic Turner's syndrome karyotype 45,X/47,XXX who conceived spontaneously and had two successful pregnancies. Short stature was the only manifestation of Turner's syndrome. In the present report, we reviewed the available literature on the fertility of women with Turner's syndrome and the phenotypic effects of mosaicism for a 47,XXX cell line in Turner's syndrome.

Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF).

PubMed

Barratt, Shaney L; Blythe, Thomas; Ourradi, Khadija; Jarrett, Caroline; Welsh, Gavin I; Bates, David O; Millar, Ann B

2018-01-15

Dysregulation of VEGF-A bioavailability has been implicated in the development of lung injury/fibrosis, exemplified by Idiopathic Pulmonary Fibrosis (IPF). VEGF-A is a target of the hypoxic response via its translational regulation by HIF-1α. The role of hypoxia and hyperoxia in the development and progression of IPF has not been explored. In normal lung (NF) and IPF-derived fibroblasts (FF) VEGF-A xxx a protein expression was upregulated by hypoxia, mediated through activation of VEGF-A xxx a gene transcription. VEGF-A receptors and co-receptors were differentially expressed by hypoxia and hyperoxia. Our data supports a potential role for hypoxia, hyperoxia and VEGF-A xxx a isoforms as drivers of fibrogenesis.

Intergranular corrosion in AA5XXX aluminum alloys with discontinuous precipitation at the grain boundaries

NASA Astrophysics Data System (ADS)

Bumiller, Elissa

The US Navy currently uses AA5xxx aluminum alloys for structures exposed to a marine environment. These alloys demonstrate excellent corrosion resistance over other aluminum alloys (e.g., AA2xxx or AA7xxx) in this environment, filling a niche in the marine structures market when requiring a light-weight alternative to steel. However, these alloys are susceptible to localized corrosion; more specifically, intergranular corrosion (IGC) is of concern. IGC of AA5xxx alloys due to the precipitation of beta phase on the grain boundaries is a well-established phenomenon referred to as sensitization. At high degrees of sensitization, the IGC path is a continuous anodic path of beta phase particles. At lower degrees of sensitization, the beta phase coverage at the grain boundaries is not continuous. The traditional ranges of susceptibility to IGC as defined by ASTM B928 are in question due to recent studies. These studies showed that even at mid range degrees of sensitization where the beta phase is no longer continuous, IGC may still occur. Previous thoughts on IGC of these alloy systems were founded on the idea that once the grain boundary precipitate became discontinuous the susceptibility to IGC was greatly reduced. Additionally, IGC susceptibility has been defined metallurgically by compositional gradients at the grain boundaries. However, AA5xxx alloys show no compositional gradients at the grain boundaries, yet are still susceptible to IGC. The goal of this work is to establish criteria necessary for IGC to occur given no continuous beta phase path and no compositional gradient at the grain boundaries. IGC performance of the bulk alloy system AA5083 has been studied along with the primary phases present in the IGC system: alpha and beta phases using electrochemistry and modeling as the primary tools. Numerical modeling supports that at steady-state the fissure tip is likely saturated with Mg in excess of the 4% dissolved in the matrix. By combining these results, quantitative insights into the IGC susceptibility of AA5xxx alloys is gained. As the aspect ratio increases, the concentration of metal ions in the fissure solution increases, thus driving up the ability to form corrosion product, whether precipitate or gelatinous product. As the theta beta increases, the IGC rates increase for a constant potential. By a combination of aspect ratio, φp, thetabeta, and likely fissure chemistry, the potential drop within the fissure is fully described and the IGC penetration rate can be predicted.

Case report of a 22-week fetus with 47,XXX karyotype and multiple lower mesodermal defects.

PubMed

Hoang, M P; Wilson, K S; Schneider, N R; Timmons, C F

1999-01-01

A 22-week stillborn fetus with 47,XXX karyotype had lower mesodermal defects consisting of irregular fusion of the sacral vertebrae, anal agenesis, multicystic dysplasia of a horseshoe kidney, a single umbilical artery, dysplastic ovaries, and uterine hypoplasia. This case provides additional evidence for an association between trisomy X and genitourinary defects including lower mesodermal defects sequence.

Exact solution of the XXX Gaudin model with generic open boundaries

NASA Astrophysics Data System (ADS)

Hao, Kun; Cao, Junpeng; Yang, Tao; Yang, Wen-Li

2015-03-01

The XXX Gaudin model with generic integrable open boundaries specified by the most general non-diagonal reflecting matrices is studied. Besides the inhomogeneous parameters, the associated Gaudin operators have six free parameters which break the U(1) -symmetry. With the help of the off-diagonal Bethe ansatz, we successfully obtained the eigenvalues of these Gaudin operators and the corresponding Bethe ansatz equations.

Federal Funds for Research and Development: Fiscal Years 1980, 1981, and 1982. Volume XXX. Detailed Statistical Tables. Surveys of Science Resources Series.

ERIC Educational Resources Information Center

National Science Foundation, Washington, DC.

During the March through July 1981 period a total of 36 Federal agencies and their subdivisions (95 individual respondents) submitted data in response to the Annual Survey of Federal Funds for Research and Development, Volume XXX, conducted by the National Science Foundation. The detailed statistical tables presented in this report were derived…

Tripeptide inhibitors of Yersinia protein-tyrosine phosphatase.

PubMed

Lee, Kyeong; Gao, Yang; Yao, Zhu-Jun; Phan, Jason; Wu, Li; Liang, Jiao; Waugh, David S; Zhang, Zhong-Yin; Burke, Terrence R

2003-08-04

The protein-tyrosine phosphatase (PTP) 'YopH' is a virulence factor of Yersinia pestis, the causative agent of plague. Potential use of Yersinia as a bioterrorism agent renders YopH inhibitors of therapeutic importance. Previously, we had examined the inhibitory potencies of a variety of phosphotyrosyl (pTyr) mimetics against the human PTP1B enzyme by displaying them in the EGFR-derived hexapeptide sequence, 'Ac-Asp-Ala-Asp-Glu-Xxx-Leu-amide', where Xxx=pTyr mimetic. The poor inhibitory potencies of certain of these pTyr mimetics were attributed to restricted orientation within the PTP1B catalytic pocket incurred by extensive peripheral interaction of the hexapeptide platform. Utilizing the smaller tripeptide platform, 'Fmoc-Glu-Xxx-Leu-amide' we demonstrate herein that several of the low affinity hexapeptide-expressed pTyr mimetics exhibit high PTP1B affinity within the context of the tripeptide platform. Of particular note, the mono-anionic 4-(carboxydifluoromethyl)Phe residue exhibits affinity equivalent to the di-anionic F(2)Pmp residue, which had previously been among the most potent PTP-binding motifs. Against YopH, it was found that all tripeptides having Glu residues with an unprotected side chain carboxyl were inactive. Alternatively, in their Glu-OBn ester forms, several of the tripeptides exhibited good YopH affinity with the mono-anionic peptide, Fmoc-Glu(OBn)-Xxx-Leu-amide, where Xxx=4-(carboxymethyloxy)Phe providing an IC(50) value of 2.8 microM. One concern with such inhibitors is that they may potentially function by non-specific mechanisms. Studies with representative inhibitors, while failing to provide evidence of a non-specific promiscuous mode of inhibition, did indicate that non-classical inhibition may be involved.

VEGF(121)b, a new member of the VEGF(xxx)b family of VEGF-A splice isoforms, inhibits neovascularisation and tumour growth in vivo.

PubMed

Rennel, E S; Varey, A H R; Churchill, A J; Wheatley, E R; Stewart, L; Mather, S; Bates, D O; Harper, S J

2009-10-06

The key mediator of new vessel formation in cancer and other diseases is VEGF-A. VEGF-A exists as alternatively spliced isoforms - the pro-angiogenic VEGF(xxx) family generated by exon 8 proximal splicing, and a sister family, termed VEGF(xxx)b, exemplified by VEGF(165)b, generated by distal splicing of exon 8. However, it is unknown whether this anti-angiogenic property of VEGF(165)b is a general property of the VEGF(xxx)b family of isoforms. The mRNA and protein expression of VEGF(121)b was studied in human tissue. The effect of VEGF(121)b was analysed by saturation binding to VEGF receptors, endothelial migration, apoptosis, xenograft tumour growth, pre-retinal neovascularisation and imaging of biodistribution in tumour-bearing mice with radioactive VEGF(121)b. The existence of VEGF(121)b was confirmed in normal human tissues. VEGF(121)b binds both VEGF receptors with similar affinity as other VEGF isoforms, but inhibits endothelial cell migration and is cytoprotective to endothelial cells through VEGFR-2 activation. Administration of VEGF(121)b normalised retinal vasculature by reducing both angiogenesis and ischaemia. VEGF(121)b reduced the growth of xenografted human colon tumours in association with reduced microvascular density, and an intravenous bolus of VEGF(121)b is taken up into colon tumour xenografts. Here we identify a second member of the family, VEGF(121)b, with similar properties to those of VEGF(165)b, and underline the importance of the six amino acids of exon 8b in the anti-angiogenic activity of the VEGF(xxx)b isoforms.

Female-to-male transsexual with 47,XXX karyotype.

PubMed

Turan, M T; Eşel, E; Dündar, M; Candemir, Z; Baştürk, M; Sofuoğlu, S; Ozkul, Y

2000-12-01

There are few reports describing chromosomal abnormalities in transsexuals. In rare cases, transsexualism and sexual chromosomal multiplicity coexist. Six cases of male-to-female transsexuals with 47,XYY chromosomal pattern have been previously reported. We have not encountered any female transsexual cases with 47,XXX karyotype in the literature. A 21-year-old female patient came to our outpatient department with depressive symptoms and suicidal thoughts. On psychiatric interview, she reported that she had feelings of discomfort with her gender identity and had desired to be male since her childhood. Then, we performed cytogenetic investigation using blood culture and G chromosome banding. Histology and DNA histograms of the patient revealed a chromosomal pattern of 47,XXX. We conclude that sexual chromosomal abnormalities in some transsexuals may cause a vulnerability to development of a gender identity disorder.

A case of premature ovarian failure (POF) in a 31-year-old woman with a 47,XXX karyotype.

PubMed

Skałba, Piotr; Cygal, Anna; Gierzyńska, Zuzanna

2010-01-01

A case of POF in a 31-year-old woman with karyotype 47,XXX. The aim of the study was to discuss a case of POF in a 31-year-old patient with polysomy 47,XXX. The described karyotype is not usually associated with this characteristic physical phenotype. In some rare cases, menstrual disorders, sterility, secondary amenorrhoea, premature menopause, and low intelligence are found. Our observations revealed the necessity for cytogenetic examination in all women at reproductive age with symptoms of premature ovarian failure. According to the data found in literature, patients with POF and karyotype disorders belong to the risk group of premature death, mostly for cardiological reasons. Raising patient awareness about the risk may have a positive effect on quality of life and regularity of check-ups.

Acoustic Radiation Force Impulse Elastography for Efficacy Evaluation after Hepatocellular Carcinoma Radiofrequency Ablation: A Comparative Study with Contrast-Enhanced Ultrasound

PubMed Central

Xu, Xiaohong; Luo, Liangping; Chen, Jiexin; Wang, Jiexin; Zhou, Honglian; Li, Mingyi; Jin, Zhanqiang; Chen, Nianping; Miao, Huilai; Lin, Manzhou; Dai, Wei; Ahuja, Anil T.; Wang, Yi-Xiang J.

2014-01-01

Aim. To explore acoustic radiation force impulse (ARFI) elastography in assessing residual tumors of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA). Materials and Methods. There were 83 HCC lesions among 72 patients. All patients were examined with ARFI, contrast enhanced ultrasound (CEUS), and CT or MRI. Tumor brightness on virtual touch tissue imaging (VTI) and shear wave velocity (SWV) were assessed before and approximately one month after RFA. Results. There were 14 residual tumors after RFA. VTI showed that all the tumors were darker after RFA. VTI was not able to distinguish the ablated lesions and the residual tumors. 13 residual tumor lesions were detected by CEUS. All completely ablated nodules had SWV demonstration of x.xx., while with those residual nodules, 6 tumors had x.xx measurement and 8 tumors had measurable SWV. nine lesions with residual tumors occurred in cirrhosis subjects and 5 lesions with residual tumors occurred in fibrosis subjects; there was no residual tumor in the normal liver subjects. Conclusion. VTI technique cannot demonstrate residual tumor post RFA. While SWV measurement of less than x.xx is likely associated with residual tumors, measurement of less than x.xx cannot exclude residual tumors. Liver cirrhosis is associated with decreased chance of a complete ablation. PMID:24895624

Triple X Egyptian woman and a Down's syndrome offspring

PubMed Central

El-Dahtory, Faeza Abdel Mogib

2013-01-01

The 47, XXX karyotype (triple X) has a frequency of 1 in 1000 female newborns. However, this karyotype is not usually suspected at birth or childhood. Female patients with a sex chromosome abnormality may be fertile. In patients with a 47, XXX cell line there appears to be an increased risk of a cytogenetically abnormal child but the extent of this risk cannot yet be determined; it is probably lower in the non-mosaic 47, XXX patient than the mosaic 46, XX/47, XXX one. We describe a new rare case of triple X woman and a Down's syndrome offspring. The patient is 26 years of age. She is a housewife, her height is 160 cm and weight is 68 kg and her physical features and mentality are normal. She has had one pregnancy at the age of 25 years resulted in a girl with Down's syndrome. The child had 47 chromosomes with trisomy 21 (47, XX, +21) Figure 1. The patient also has 47 chromosomes with a triple X karyotype (47, XX, +X) Figure 2. The patient's husband (27 years old) is physically and mentally normal. He has 46 chromosomes with a normal XY karyotype (46, XY). There are neither Consanguinity between her parent's nor she and her husband. PMID:23901206

Access of Hydrogen-Radicals to the Peptide-Backbone as a Measure for Estimating the Flexibility of Proteins Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

PubMed Central

Takayama, Mitsuo; Nagoshi, Keishiro; Iimuro, Ryunosuke; Inatomi, Kazuma

2014-01-01

A factor for estimating the flexibility of proteins is described that uses a cleavage method of “in-source decay (ISD)” coupled with matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS). The MALDI-ISD spectra of bovine serum albumin (BSA), myoglobin and thioredoxin show discontinuous intense ion peaks originating from one-side preferential cleavage at the N-Cα bond of Xxx-Asp, Xxx-Asn, Xxx-Cys and Gly-Xxx residues. Consistent with these observations, Asp, Asn and Gly residues are also identified by other flexibility measures such as B-factor, turn preference, protection and fluorescence decay factors, while Asp, Asn, Cys and Gly residues are identified by turn preference factor based on X-ray crystallography. The results suggest that protein molecules embedded in/on MALDI matrix crystals partly maintain α-helix and that the reason some of the residues are more susceptible to ISD (Asp, Asn, Cys and Gly) and others less so (Ile and Val) is because of accessibility of the peptide backbone to hydrogen-radicals from matrix molecules. The hydrogen-radical accessibility in MALDI-ISD could therefore be adopted as a factor for measuring protein flexibility. PMID:24828203

Gilles de la Tourette's syndrome in a patient with 47(XXX) syndrome: a case report.

PubMed

Chiappedi, Matteo; de Vincenzi, Silvia; Dolci, Roberta; De Luca, Sara; Bejor, Maurizio

2011-11-05

To the best of our knowledge, this is the first report of a comorbidity between Gilles de la Tourette's syndrome and 47 (XXX) syndrome. The clinical picture of Gilles de la Tourette's Syndrome is well described, while 47 (XXX) syndrome is much more rare and has a broader spectrum of possible phenotypic presentations. An Italian Caucasian girl was referred at the age of 11 to our Rehabilitation Center for anxiety and learning difficulties. The girl had already been diagnosed as having 47(XXX) syndrome; she had some rather typical features of the chromosomal abnormality, but she also showed a high level of anxiety and the presence of motor and vocal tics. When an accurate history was taken, a diagnosis of Gilles de la Tourette's Syndrome emerged. The possible interaction between peculiar features of these two syndromes in terms of neuropsychological and affective functioning is both interesting for the specific case and to hypothesize models of rehabilitation for patients with one or both syndromes. Executive functions are specifically reduced in both syndromes, therefore it might be hard to discriminate the contribution of each one to the general impairment; the same applies to anxiety. Moreover, mental retardation (with a significantly lower verbal cognitive functioning) poses relevant problems when suggesting cognitive behavioral or psychoeducational rehabilitative approaches.

3-D Imagery Cockpit Display Development

DTIC Science & Technology

1990-08-01

and ownship appeared in the lower right corner of the CLF, in the form XXX NM. The third data line showed individual aircraft altitude in the form XX K...data line showed aircraft heading in the form XXX ° . 4.2.5.3 Close-Look Format Options The Close-Look Format option switches are shown in Figure 4.2...vector, it is Need for declutter levels, redundant. Need range readout. Needs basic altitude reference. Low altitude warning system with sexy female

Thermal Exposure and Environment Effects on Tension, Fracture and Fatigue of 5XXX Alloys Tested in Different Orientations

DTIC Science & Technology

2017-12-27

were determined and the effects of changes in loading rate and solution on this susceptibility were determined. Technical Approach The technical... approach followed in this completed work has been to conduct quasi- static fracture and fatigue experiments on 5XXX commercial aluminum alloys of interest...Metallic Materials Studied by Correlative Tomography", in 38th Riso International Symposium on Materials Science - IOP Conf. Series: Materials Science

Thermally Cross-Linked Anion Exchange Membranes from Solvent Processable Isoprene Containing Ionomers

DTIC Science & Technology

2015-01-15

isoprene determined by 1H NMR of each copolymer. Hydration Macromolecules Article DOI: 10.1021/ma502362a Macromolecules XXXX, XXX, XXX−XXX B number (λ) is...C. This is attributed to the decomposition of the TMA groups. Slight weight loss at lower temperatures is presumably due to the loss of trapped water...that at sufficiently high hydration levels the diffusion coefficient of ions approach their dilute solution diffusivity limits.30 Since conductivity is

NASA-UVA Light Aerospace Alloy and Structure Technology Program Supplement: Aluminum-Based Materials for High Speed Aircraft

NASA Technical Reports Server (NTRS)

Starke, E. A., Jr.

1997-01-01

This is the final report of the study "Aluminum-Based Materials for High Speed Aircraft" which had the objectives (1) to identify the most promising aluminum-based materials with respect to major structural use on the HSCT and to further develop those materials and (2) to assess the materials through detailed trade and evaluation studies with respect to their structural efficiency on the HSCT. The research team consisted of ALCOA, Allied-Signal, Boeing, McDonnell Douglas, Reynolds Metals and the University of Virginia. Four classes of aluminum alloys were investigated: (1) I/M 2XXX containing Li and I/M 2XXX without Li, (2) I/M 6XXX, (3) two P/M 2XXX alloys, and (4) two different aluminum-based metal matrix composites (MMC). The I/M alloys were targeted for a Mach 2.0 aircraft and the P/M and MMC alloys were targeted for a Mach 2.4 aircraft. Design studies were conducted using several different concepts including skin/stiffener (baseline), honeycomb sandwich, integrally stiffened and hybrid adaptations (conventionally stiffened thin-sandwich skins). Alloy development included fundamental studies of coarsening behavior, the effect of stress on nucleation and growth of precipitates, and fracture toughness as a function of temperature were an integral part of this program. The details of all phases of the research are described in this final report.

Gilles de la Tourette's syndrome in a patient with 47(XXX) syndrome: a case report

PubMed Central

2011-01-01

Introduction To the best of our knowledge, this is the first report of a comorbidity between Gilles de la Tourette's syndrome and 47 (XXX) syndrome. The clinical picture of Gilles de la Tourette's Syndrome is well described, while 47 (XXX) syndrome is much more rare and has a broader spectrum of possible phenotypic presentations. Case presentation An Italian Caucasian girl was referred at the age of 11 to our Rehabilitation Center for anxiety and learning difficulties. The girl had already been diagnosed as having 47(XXX) syndrome; she had some rather typical features of the chromosomal abnormality, but she also showed a high level of anxiety and the presence of motor and vocal tics. When an accurate history was taken, a diagnosis of Gilles de la Tourette's Syndrome emerged. Conclusions The possible interaction between peculiar features of these two syndromes in terms of neuropsychological and affective functioning is both interesting for the specific case and to hypothesize models of rehabilitation for patients with one or both syndromes. Executive functions are specifically reduced in both syndromes, therefore it might be hard to discriminate the contribution of each one to the general impairment; the same applies to anxiety. Moreover, mental retardation (with a significantly lower verbal cognitive functioning) poses relevant problems when suggesting cognitive behavioral or psychoeducational rehabilitative approaches. PMID:22054059

Neurospora tryptophan synthase: N-terminal analysis and the sequence of the pyridoxal phosphate active site peptide

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pratt, M.L.; Hsu, P.Y.; DeMoss, J.A.

1986-05-01

Tryptophan synthase (TS), which catalyzes the final step of tryptophan biosynthesis, is a multifunctional protein requiring pyridoxal phosphate (B6P) for two of its three distinct enzyme activities. TS from Neurospora has a blocked N-terminal, is a homodimer of 150 KDa and binds one mole of B6P per mole of subunit. The authors shown the N-terminal residue to be acyl-serine. The B6P-active site of holoenzyme was labelled by reduction of the B6P-Schiff base with (/sup 3/H)-NaBH/sub 4/, and resulted in a proportionate loss of activity in the two B6P-requiring reactions. SDS-polyacrylamide gel electrophoresis of CNBr-generated peptides showed the labelled, active sitemore » peptide to be 6 KDa. The sequence of this peptide, purified to apparent homogeneity by a combination of C-18 reversed phase and TSK gel filtration HPLC is: gly-arg-pro-gly-gln-leu-his-lys-ala-glu-arg-leu-thr-glu-tyr-ala-gly-gly-ala-gln-ile-xxx-leu-lys-arg-glu-asp-leu-asn-his-xxx-gly-xxx-his-/sub ***/-ile-asn-asn-ala-leu. Although four residues (xxx, /sub ***/) are unidentified, this peptide is minimally 78% homologous with the corresponding peptide from yeast TS, in which residue (/sub ***/) is the lysine that binds B6P.« less

One motif to bind them: A small-XXX-small motif affects transmembrane domain 1 oligomerization, function, localization, and cross-talk between two yeast GPCRs.

PubMed

Lock, Antonia; Forfar, Rachel; Weston, Cathryn; Bowsher, Leo; Upton, Graham J G; Reynolds, Christopher A; Ladds, Graham; Dixon, Ann M

2014-12-01

G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors in mammals and facilitate a range of physiological responses triggered by a variety of ligands. GPCRs were thought to function as monomers, however it is now accepted that GPCR homo- and hetero-oligomers also exist and influence receptor properties. The Schizosaccharomyces pombe GPCR Mam2 is a pheromone-sensing receptor involved in mating and has previously been shown to form oligomers in vivo. The first transmembrane domain (TMD) of Mam2 contains a small-XXX-small motif, overrepresented in membrane proteins and well-known for promoting helix-helix interactions. An ortholog of Mam2 in Saccharomyces cerevisiae, Ste2, contains an analogous small-XXX-small motif which has been shown to contribute to receptor homo-oligomerization, localization and function. Here we have used experimental and computational techniques to characterize the role of the small-XXX-small motif in function and assembly of Mam2 for the first time. We find that disruption of the motif via mutagenesis leads to reduction of Mam2 TMD1 homo-oligomerization and pheromone-responsive cellular signaling of the full-length protein. It also impairs correct targeting to the plasma membrane. Mutation of the analogous motif in Ste2 yielded similar results, suggesting a conserved mechanism for assembly. Using co-expression of the two fungal receptors in conjunction with computational models, we demonstrate a functional change in G protein specificity and propose that this is brought about through hetero-dimeric interactions of Mam2 with Ste2 via the complementary small-XXX-small motifs. This highlights the potential of these motifs to affect a range of properties that can be investigated in other GPCRs. Copyright © 2014. Published by Elsevier B.V.

Tailoring nanostructured, graded, and particle-reinforced Al laminates by accumulative roll bonding.

PubMed

Göken, Mathias; Höppel, Heinz Werner

2011-06-17

Accumulative roll bonding (ARB) is a very attractive process for processing large sheets to achieve ultrafine-grained microstructure and high strength. Commercial purity Al and many Al alloys from the 5xxx and the precipitation strengthened 6xxx alloy series have been successfully processed by the ARB process into an ultrafine-grained state and superior ductility have been achieved for some materials like technical purity Al. It has also been shown that the ARB process can be successfully used to produce multi-component materials with tailored properties by reinforcement or grading, respectively. This allows optimizing the properties based on two or more materials/alloys. For example, to achieve high corrosion resistance and good visual surface properties it is interesting to produce a composite of two different Al alloys, where for example a high strength alloy of the 5xxx series is used as the core material and a 6xxx series alloy as the clad material. It has been shown that such a composite achieves more or less the same strength as the core material although 50% of the composite consists of the significant softer clad alloy. Furthermore, it has been found, that the serrated yielding which typically appears in 5xxx series alloys and limits applications as outer skin materials completely disappears. Moreover, the ARB process allows many other attractive ways to design new composites and graded material structures with unique properties by the introduction of particles, fibres and sheets. Strengthening with nanoparticles for example is a very attractive way to improve the properties and accelerate the grain refining used in the severe plastic deformation process. With an addition of only 0.1 vol.-% Al2O3 nanoparticles a significantly accelerated grain refinement has been found which reduces the number of ARB passes necessary to achieve the maximum in strength. The paper provides a short review on recent developments in the field of ARB processing for producing multicomponent ultrafine-grained sheet materials with tailored properties.

Sensitization of Naturally Aged Aluminum 5083 Armor Plate

DTIC Science & Technology

2015-07-29

susceptibility to intergranular corrosion of 5XXX series aluminum alloys by mass loss after exposure to nitric acid (NAMLT Test)”, ASTM G-67-04. [6...67 nitric acid mass-loss values were 19 to 25 mg/cm2. The transmission electron microscopy microstructure of the sample was found to be consistent...5XXX Series Aluminum Alloys by Mass Loss after Exposure to Nitric Acid “ was used as an assessment of the degree of sensitization (DOS) of the alloy.[5

Slavnov and Gaudin-Korepin Formulas for Models without U(1) Symmetry: the Twisted XXX Chain

NASA Astrophysics Data System (ADS)

Belliard, Samuel; Pimenta, Rodrigo A.

2015-12-01

We consider the XXX spin-1/2 Heisenberg chain on the circle with an arbitrary twist. We characterize its spectral problem using the modified algebraic Bethe anstaz and study the scalar product between the Bethe vector and its dual. We obtain modified Slavnov and Gaudin-Korepin formulas for the model. Thus we provide a first example of such formulas for quantum integrable models without U(1) symmetry characterized by an inhomogenous Baxter T-Q equation.

Turner syndrome and 45,X/47,XXX mosaicism.

PubMed

Akbas, E; Mutluhan, H; Savasoglu, K; Soylemez, F; Ozturk, I; Yazici, G

2009-01-01

The occurrence of double aneuploidy is a relatively rare phenomenon. We report on a 17-year-old woman with short stature, minimal pubic and axillar hair and short hands. In cultured lymphocyte a double aneuploidy mosaicism was detected, consisting of a cell line with trisomy for X chromosome and a cell line with monosomy for the X-chromosome and no cell line with a normal karyotype. To our knowledge, this is the first case of mosaic 45,X/47,XXX in Turkey.

Department of the Navy Correspondence Manual

DTIC Science & Technology

2010-03-01

Abbreviated rank for officers and rate and warfare designator for enlisted personnel (e.g., AD1(AW), BM2(SW), CSSN(SS)) with no space between rank/rate and...warfare designator , (2) first name, middle initial if any, and last name, (3) staff corps abbreviation (if any), (4) branch of service, (5) the last four...digits of the SSN, and (6) the designator for an officer. EXAMPLE: RADM Michelle L. Howard, USN, XXX-XX-1234/1110 CDR Gilbert L. Williams, USN, XXX-XX

Computer-Based Instruction in Military Environments: Defense Research Series. Volume 1

DTIC Science & Technology

1987-01-01

following papers you will find both a practical and scientific basis for the way current and future training and training systems shouli be designed, applied...should be expended on the many payoffs of computer based instructional techniques. As you study these papers be aware that they are only part of the...your goal is to accomplish XXX, you should next do YYY" Conceptual Model orientation: "XXX will effect YYY by accomplishing ZZZ, which in turn effects

Prenatal diagnosis and genetic analysis of double trisomy 48,XXX,+18.

PubMed

Chen, C P; Chern, S R; Yeh, L F; Chen, W L; Chen, L F; Wang, W

2000-09-01

Prenatal diagnosis of simultaneous occurrence of double trisomy involving chromosomes 18 and X is extremely rare. We report on the prenatal diagnosis, genetic analysis and clinical manifestations of a fetus with both trisomy 18 and trisomy X. A 26-year-old, para 1 woman was referred for genetic counselling at 36 weeks' gestation with the sonographic findings of intrauterine growth retardation (IUGR), polyhydramnios, ventricular septal defect, and an enlarged cisterna magna. Both cordocentesis and amniocentesis revealed a consistent karyotype of 48,XXX,+18. Quantitative fluorescent polymerase chain reaction using polymorphic small tandem repeat markers specific for chromosomes 18 and X rapidly determined that both aneuploidies arose as a result of non-disjunction in maternal meiosis II. Our case shows that two non-disjunction events can occur not only in the same parent, but also in the same cell division. Our case also shows that double trisomy, 48,XXX,+18, can demonstrate an enlarged cisterna magna, IUGR and polyhydramnios in prenatal ultrasound. Copyright 2000 John Wiley & Sons, Ltd.

A microstructure-based yield stress and work-hardening model for textured 6xxx aluminium alloys

NASA Astrophysics Data System (ADS)

Khadyko, M.; Myhr, O. R.; Dumoulin, S.; Hopperstad, O. S.

2016-04-01

The plastic properties of an aluminium alloy are defined by its microstructure. The most important factors are the presence of alloying elements in the form of solid solution and precipitates of various sizes, and the crystallographic texture. A nanoscale model that predicts the work-hardening curves of 6xxx aluminium alloys was proposed by Myhr et al. The model predicts the solid solution concentration and the particle size distributions of different types of metastable precipitates from the chemical composition and thermal history of the alloy. The yield stress and the work hardening of the alloy are then determined from dislocation mechanics. The model was largely used for non-textured materials in previous studies. In this work, a crystal plasticity-based approach is proposed for the work hardening part of the nanoscale model, which allows including the influence of the crystallographic texture. The model is evaluated by comparison with experimental data from uniaxial tensile tests on two textured 6xxx alloys in five temper conditions.

Electron Excitation Cross Sections for the 2s(sup 2)2p(sup 3) (sup 4)S -> 2s(sup 2)2p(sup 3) (sup 2d) ->2s2p(sup 4) (sup 4p) (Resonance) Transitions in Oil

NASA Technical Reports Server (NTRS)

Zuo, M.; Smith, S.; Chutjian, A.; Williams, I.; Tayal, S.; McLaughlin, B.

1994-01-01

Experimental and theoretical excitation cross sections are reported for the first forbidden transition xxx and the first allowed (resonance) transition xxx in OII. Use is made of electron-energy loss and merged beams methods. The electron energy range covered is 3.33 eV (threshold) to 15 eV for the S->D transition, and 14.9 eV (threshold) to 40 eV for the S->P transition. Care was taken to assess and minimize the metastable fraction of the OII beam. An electron mirror was designed and tested to reflect inelastically back-scattered electrons into the forward direction to account for the full range of polar scattering angles. Comparisons are made between present experiments and 11-state R-Matrix calculations. Calculations are also presented for the xxx transition.

Lipid solvation effects contribute to the affinity of Gly-xxx-Gly motif-mediated helix-helix interactions.

PubMed

Johnson, Rachel M; Rath, Arianna; Melnyk, Roman A; Deber, Charles M

2006-07-18

Interactions between transmembrane helices are mediated by the concave Gly-xxx-Gly motif surface. Whether Gly residues per se are sufficient for selection of this motif has not been established. Here, we used the in vivo TOXCAT assay to measure the relative affinities of all 18 combinations of Gly, Ala, and Ser "small-xxx-small" mutations in glycophorin A (GpA) and bacteriophage M13 major coat protein (MCP) homodimers. Affinity values were compared with the accessibility to a methylene-sized probe of the total surface area of each helix monomer as a measure of solvation by membrane components. A strong inverse correlation was found between nonpolar-group lipid accessibility and dimer affinity (R = 0.75 for GpA, p = 0.013, and R = 0.81 for MCP, p = 0.004), suggesting that lipid as a poor membrane protein solvent, conceptually analogous to water in soluble protein folding, can contribute to dimer stability and help to define helix-helix interfaces.

Novel selective human melanocortin-3 receptor ligands: Use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold

PubMed Central

Ballet, Steven; Mayorov, Alexander V.; Cai, Minying; Tymecka, Dagmara; Chandler, Kevin B.; Palmer, Erin S.; Van Rompaey, Karolien; Misicka, Aleksandra; Tourwé, Dirk; Hruby, Victor J.

2008-01-01

In search of new selective antagonists and/or agonists for the human melanocortin receptor subtypes hMC1R to hMC5R to elucidate the specific biological roles of each GPCR, we modified the structures of the superagonist MT-II (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2) and the hMC3R/hMC4R antagonist SHU9119 (Ac-Nle-c[Asp-His-D-Nal(2′)-Arg-Trp-Lys]-NH2) by replacing the His-D-Phe and His-D-Nal(2′) fragments in MT-II and SHU9119, respectively, with Aba-Xxx (4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one-Xxx) dipeptidomimetics (Xxx = D-Phe/pCl-D-Phe/D-Nal(2′)). Employment of the Aba mimetic yielded novel selective high affinity hMC3R and hMC3R/hMC5R antagonists. PMID:17314042

Genotype- phenotype correlation in trisomy X: a retrospective study of a selected group of 36 patients and review of literature.

PubMed

Butnariu, Lăcrămioara; Rusu, Cristina; Caba, Lavinia; Pânzaru, Monica; Braha, Elena; Grămescu, Mihaela; Popescu, Roxana; Bujoranu, C; Gorduza, E V

2013-01-01

Trisomy X (47,XXX) is a gonosomal aneuploidy characterized by the presence of an extra X chromosome in a female person. Usually the diagnosis is established made postnatally by chromosome analysis in patients with suggestive clinical signs. Clinical signs vary by age. In prepubertal patients have a growth retardation associated with uncharacteristic facial dysmorphism, mild mental retardation with behavioral disorders, plus clinical signs of ovarian dysgenesis, postpubertal. We analyzed retrospectively the genotype - phenotype correlations for a selected group of 36 patients diagnosed with trisomy X (homogeneous or mosaic) by cytogenetic methods (X chromatin and karyotype). Analysis of the clinical data of 36 patients diagnosed with trisomy X and correlation with the results of X chromatin and karyotype. Clinical signs detected in patients with homogeneous trisomy X 47,XXX (22.22%), mosaic 46,XX/47,XXX (16.66%) or 47,XXX/48,XXXX (5.55%) were prepubertal, growth retardation associated with dysmorphic facial (upslanted palpebral fissure, epichantus, thin lips) and postpubertal, signs of ovarian dysgenesis (secondary amenorrhea, early menopause). The phenotype of patients with different gonosomal mosaic corresponding to Turner syndrome, incorporating a cell line with trisomy X (55.55%) was variable, correlated with the type of chromosomal abnormalities detected. The results of our study are similar to those obtained in other studies and emphasizes that phenotypic variability of patients with trisomy X feature makes it difficult to genotype - phenotype correlations.

Rare X Chromosome Abnormalities in Systemic Lupus Erythematosus and Sjögren's Syndrome.

PubMed

Sharma, Rohan; Harris, Valerie M; Cavett, Joshua; Kurien, Biji T; Liu, Ke; Koelsch, Kristi A; Fayaaz, Anum; Chaudhari, Kaustubh S; Radfar, Lida; Lewis, David; Stone, Donald U; Kaufman, C Erick; Li, Shibo; Segal, Barbara; Wallace, Daniel J; Weisman, Michael H; Venuturupalli, Swamy; Kelly, Jennifer A; Pons-Estel, Bernardo; Jonsson, Roland; Lu, Xianglan; Gottenberg, Jacques-Eric; Anaya, Juan-Manuel; Cunninghame-Graham, Deborah S; Huang, Andrew J W; Brennan, Michael T; Hughes, Pamela; Alevizos, Ilias; Miceli-Richard, Corinne; Keystone, Edward C; Bykerk, Vivian P; Hirschfield, Gideon; Nordmark, Gunnel; Bucher, Sara Magnusson; Eriksson, Per; Omdal, Roald; Rhodus, Nelson L; Rischmueller, Maureen; Rohrer, Michael; Wahren-Herlenius, Marie; Witte, Torsten; Alarcón-Riquelme, Marta; Mariette, Xavier; Lessard, Christopher J; Harley, John B; Ng, Wan-Fai; Rasmussen, Astrid; Sivils, Kathy L; Scofield, R Hal

2017-11-01

Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE) are related by clinical and serologic manifestations as well as genetic risks. Both diseases are more commonly found in women than in men, at a ratio of ~10 to 1. Common X chromosome aneuploidies, 47,XXY and 47,XXX, are enriched among men and women, respectively, in either disease, suggesting a dose effect on the X chromosome. We examined cohorts of SS and SLE patients by constructing intensity plots of X chromosome single-nucleotide polymorphism alleles, along with determining the karyotype of selected patients. Among ~2,500 women with SLE, we found 3 patients with a triple mosaic, consisting of 45,X/46,XX/47,XXX. Among ~2,100 women with SS, 1 patient had 45,X/46,XX/47,XXX, with a triplication of the distal p arm of the X chromosome in the 47,XXX cells. Neither the triple mosaic nor the partial triplication was found among the controls. In another SS cohort, we found a mother/daughter pair with partial triplication of this same region of the X chromosome. The triple mosaic occurs in ~1 in 25,000-50,000 live female births, while partial triplications are even rarer. Very rare X chromosome abnormalities are present among patients with either SS or SLE and may inform the location of a gene(s) that mediates an X dose effect, as well as critical cell types in which such an effect is operative. © 2017, American College of Rheumatology.

Comparing sex steroid levels during the annual cycles of rainbow trout (Oncorhynchus mykiss) diploid female (XX) and triploid female (XXX) genotypic sex.

PubMed

Espinosa, E; Josa, A; Gil, L; Malo, C; Mitjana, O

2013-02-01

In this study, the annual cycle of the gonadal steroids testosterone (T), 11-ketotestosterone (11-KT), 17β-estradiol (E2) and 17α, 20β-dihydroxy-4-pregnen-3-one (DHP) was determined using radioimmunoassay and then compared for two populations of rainbow trout, XX diploid females (n = 40) and XXX triploid females (n = 15). In females, E2 and DHP levels were found to be significantly related to body weight (r = 0.22513; p < 0.0001 and r = 0.15831; p > 0.001, respectively). In this group, E2 concentrations peaked in November (25.05 ng/ml), while maximum DHP levels, only measurable from October to April, were attained in February (64.14 ng/ml). No significant differences in hormone ranges related to egg output ability were observed. Finally, sex steroid concentrations were low in the triploid female XXX fish compared to the female XX population. Nevertheless, maximum T (33.85 ng/ml) and 11-KT (32.35 ng/ml) levels were recorded in January, for XXX. The levels for these two hormones are relatively high and are also significantly associated (r = 0.8430; p < 0.0001). Diploid females showed significantly higher levels of E2 than triploids over the 12-month study period. The female triploid fish produced the lowest steroid hormone levels, such that these would be the most suitable for human consumption. © 2012 Blackwell Verlag GmbH.

Scalar formalism for non-Abelian gauge theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hostler, L.C.

1986-09-01

The gauge field theory of an N-italic-dimensional multiplet of spin- 1/2 particles is investigated using the Klein--Gordon-type wave equation )Pi x (1+i-italicsigma) x Pi+m-italic/sup 2/)Phi = 0, Pi/sub ..mu../equivalentpartial/partiali-italicx-italic/sub ..mu../-e-italicA-italic/sub ..mu../, investigated before by a number of authors, to describe the fermions. Here Phi is a 2 x 1 Pauli spinor, and sigma repesents a Lorentz spin tensor whose components sigma/sub ..mu..//sub ..nu../ are ordinary 2 x 2 Pauli spin matrices. Feynman rules for the scalar formalism for non-Abelian gauge theory are derived starting from the conventional field theory of the multiplet and converting it to the new description. Themore » equivalence of the new and the old formalism for arbitrary radiative processes is thereby established. The conversion to the scalar formalism is accomplished in a novel way by working in terms of the path integral representation of the generating functional of the vacuum tau-functions, tau(2,1, xxx 3 xxx)equivalent<0-chemically bondT-italic(Psi/sub in/(2) Psi-bar/sub in/(1) xxx A-italic/sub ..mu../(3)/sub in/ xxx S-italic)chemically bond0->, where Psi/sub in/ is a Heisenberg operator belonging to a 4N-italic x 1 Dirac wave function of the multiplet. The Feynman rules obtained generalize earlier results for the Abelian case of quantum electrodynamics.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Asoudeh, M.; Karimipour, V.

We determine thermal entanglement in mean-field clusters of N spin one-half particles interacting via the anisotropic Heisenberg interaction, with and without external magnetic field. For the xxx cluster in the absence of magnetic field we prove that only the N=2 ferromagnetic cluster shows entanglement. An external magnetic field B can only entangle xxx antiferromagnetic clusters in certain regions of the B-T plane. On the other hand, the xxz clusters of size N>2 are entangled only when the interaction is ferromagnetic. Detailed dependence of the entanglement on various parameters is investigated in each case.

An Analysis of the Materiel Fielding Plan for the SINCGARS (Single Channel Ground and Airborne Radio System) Radio.

DTIC Science & Technology

1984-12-01

34 sexy " topic. It is easy to see why personnel involved in the fielding for SINCGARS would not be interested in this area. However, the impact of a poor...1986 1987 1988 1989 1990 TRADOC XXXXXX FT. HOOD XXXXXXXXXXX KOREA XXXXXXX USAREUR XXXXXXXXwwwww? IIIIIIIII KEY: SINCGARS Fielded XXX IFTE Fielded III...Dou Circuiar--N-./UU- XXX . 10. U.S Department of Defense, Instructions for Materiel Fielding/Transfer, DoD Pamphl et 700-xx (Dra-t). 11. U.S

Prenatal diagnosis and gonadal findings in X/XXX mosaicism.

PubMed Central

Kohn, G; Cohen, M M; Beyth, Y; Ornoy, A

1977-01-01

Prenatal diagnosis of a case of X/XXX mosaicism is presented. In spite of the fact that over 50% of the cells cultured from both ovaries were trisomic for the X chromosome, fetal öocytes were rarely found. This case illustrates that the presence of a triple-X cell line, even in a relatively high percentage of ovarian cells, does not necessarily protect the ovary from 'aöogenesis'. This observation might prove useful in the counselling of future cases involving the prenatal detection of sex chromosome mosaicism. Images PMID:856232

Investigation on local ductility of 6xxx-aluminium sheet alloys

NASA Astrophysics Data System (ADS)

Henn, P.; Liewald, M.; Sindel, M.

2017-09-01

Within the scope of this paper influence of localization of loading conditions on the ductility of two different 6xxx-aluminium sheet alloys is investigated. In order to improve the prediction of sheet material crash performance, material parameters based on uniaxial tensile and notched tensile tests are determined with varying consolidation areas. Especially evaluation methods based on the localized necking behaviour in tensile tests are investigated. The potential of local ductility characterisation is validated with results of Edge-Compression Tests (ECT) which applies load conditions that occur in actual crash events.

Competitive formation of b(2) and c(2)-H2O ions from b(3) ions containing Asp residue during tandem mass spectrometry: the influence of neighboring Arg.

PubMed

Guo, Mengzhe; Guo, Cheng; Pan, Yuanjiang

2014-08-01

The fragmentation of b3 ions derived from protonated Arg-Xxx-Asp-Ala-Ala (Xxx = Ala, Asp, Glu, Cys) and Arg-Xxx-Glu-Ala-Ala was investigated by electrospray ionization tandem mass spectrometry (MS (n) ) with collision-induced dissociation. A particular ion, which is 1 Da less than b2 ion, is shown to be the c2-H2O ion. The mechanism for its formation involved the aspartic acid in the third position easily losing anhydride to form a c2 ion, which then lost water to form an eight-membered ring of azacyclooctane derivative under the participation of the guanidine of the N-terminal arginine. However, this phenomenon was not observed when the aspartic acid was replaced by glutamic acid. The Amber program was used to determine the conformation of the original c2 residue from the dynamic energy perspective, and then density functional theory-based calculations and changing N-terminal amino acid from arginine to phenylalanine supported this mechanism.

Pressure dependence of backbone chemical shifts in the model peptides Ac-Gly-Gly-Xxx-Ala-NH2.

PubMed

Erlach, Markus Beck; Koehler, Joerg; Crusca, Edson; Kremer, Werner; Munte, Claudia E; Kalbitzer, Hans Robert

2016-06-01

For a better understanding of nuclear magnetic resonance (NMR) detected pressure responses of folded as well as unstructured proteins the availability of data from well-defined model systems are indispensable. In this work we report the pressure dependence of chemical shifts of the backbone atoms (1)H(α), (13)C(α) and (13)C' in the protected tetrapeptides Ac-Gly-Gly-Xxx-Ala-NH2 (Xxx one of the 20 canonical amino acids). Contrary to expectation the chemical shifts of these nuclei have a nonlinear dependence on pressure in the range from 0.1 to 200 MPa. The polynomial pressure coefficients B 1 and B 2 are dependent on the type of amino acid studied. The coefficients of a given nucleus show significant linear correlations suggesting that the NMR observable pressure effects in the different amino acids have at least partly the same physical cause. In line with this observation the magnitude of the second order coefficients of nuclei being direct neighbors in the chemical structure are also weakly correlated.

Characterising ductility of 6xxx-series aluminium sheet alloys at combined loading conditions

NASA Astrophysics Data System (ADS)

Henn, Philipp; Liewald, Mathias; Sindel, Manfred

2017-10-01

This paper presents a new approach to characterise material ductility when combined, three dimensional loading conditions occurring during vehicle crash are applied. So called "axial crush test" of closed hat sections is simplified by reducing it down to a two-dimensional testing procedure. This newly developed edge-compression test (ECT) provides the opportunity to investigate a defined characteristic axial folding behaviour of a profile edge. The potential to quantify and to differentiate crashworthiness of material by use of new edge-compression test is investigated by carrying out experimental studies with two different 6xxx-aluminium sheet alloys.

How to fold a spin chain: Integrable boundaries of the Heisenberg XXX and Inozemtsev hyperbolic models

NASA Astrophysics Data System (ADS)

De La Rosa Gomez, Alejandro; MacKay, Niall; Regelskis, Vidas

2017-04-01

We present a general method of folding an integrable spin chain, defined on a line, to obtain an integrable open spin chain, defined on a half-line. We illustrate our method through two fundamental models with sl2 Lie algebra symmetry: the Heisenberg XXX and the Inozemtsev hyperbolic spin chains. We obtain new long-range boundary Hamiltonians and demonstrate that they exhibit Yangian symmetries, thus ensuring integrability of the models we obtain. The method presented provides a ;bottom-up; approach for constructing integrable boundaries and can be applied to any spin chain model.

Exact valence bond entanglement entropy and probability distribution in the XXX spin chain and the potts model.

PubMed

Jacobsen, J L; Saleur, H

2008-02-29

We determine exactly the probability distribution of the number N_(c) of valence bonds connecting a subsystem of length L>1 to the rest of the system in the ground state of the XXX antiferromagnetic spin chain. This provides, in particular, the asymptotic behavior of the valence-bond entanglement entropy S_(VB)=N_(c)ln2=4ln2/pi(2)lnL disproving a recent conjecture that this should be related with the von Neumann entropy, and thus equal to 1/3lnL. Our results generalize to the Q-state Potts model.

Energies, Wavelengths, and Transition Rates for Ga-Like Ions (Nd XXX-Tb XXXV)

NASA Astrophysics Data System (ADS)

El-Sayed, Fatma; Attia, S. M.

2016-03-01

Energies, wavelengths, transition probabilities, oscillator strengths, and line strengths have been calculated for 4s24p-4s4p2 and 4s24p-4s24d transitions in gallium-like ions from Z = 60 to 65, for Nd XXX, Pm XXXI, Sm XXXII, Eu XXXIII, Gd XXXIV, and Tb XXXV using the fully relativistic multiconfi guration Dirac-Fock method. The correlation with the n = 4 complex and the quantum electrodynamic effects have been considered in the calculations. The obtained results have been compared with the available experimental and other theoretical results.

47,XXX male: A clinical and molecular study.

PubMed

Ogata, T; Matsuo, M; Muroya, K; Koyama, Y; Fukutani, K

2001-02-01

We report a 53-year-old Japanese male with a 47,XXX karyotype. His clinical features included hypoplastic scrotal testes (4 ml bilaterally), normally formed small penis (3.8 cm), relatively poor pubic hair development (Tanner stage 3), gynecomastia, age-appropriate male height (159.1 cm), and mental retardation (verbal IQ of 56). Serum testosterone was markedly reduced (0.6 nmol/L). A needle biopsy showed severe testicular degeneration. FISH analysis revealed complex mosaicism consisting of (1) 47,XXX cells with a single copy of SRY (n = 177), two copies of SRY (n = 3), and no SRY (n = 1); (2) 46,XX cells with a single copy of SRY (n = 9) and no SRY (n = 3); (3) 45,X cells with no SRY (n = 5); and (4) 48,XXXX cells with a single copy of SRY (n = 1) and two copies of SRY (n = 1). PCR analysis showed the presence of Yp portion with the breakpoint between DYS264 and AMELY. Microsatellite analysis demonstrated three alleles for DMD and AR. X-inactivation analysis for the methylation status of the AR gene showed random inactivation of the three X chromosomes. The results suggest that this 47,XXX male has resulted from abnormal X-Y interchange during paternal meiosis and X-X nondisjunction during maternal meiosis. Complex mosaicism may be due to the age-related increase in mitotic nondisjunction which is prone to occur in rapidly dividing lymphocytes and to the presence of two randomly inactivated X chromosomes which may behave asynchronously during mitosis, and clinical features of this male would primarily be explained by the genetic information on the SRY (+) der(X) chromosome and his advanced age. Copyright 2001 Wiley-Liss, Inc.

Fetal sex chromosome testing by maternal plasma DNA sequencing: clinical laboratory experience and biology.

PubMed

Bianchi, Diana W; Parsa, Saba; Bhatt, Sucheta; Halks-Miller, Meredith; Kurtzman, Kathryn; Sehnert, Amy J; Swanson, Amy

2015-02-01

To describe the clinical experience with noninvasive prenatal testing for fetal sex chromosomes using sequencing of maternal plasma cell-free DNA in a commercial laboratory. A noninvasive prenatal testing laboratory data set was examined for samples in which fetal sex chromosomes were reported. Available clinical outcomes were reviewed. Of 18,161 samples with sex chromosome results, no sex chromosome aneuploidy was detected in 98.9% and the fetal sex was reported as XY (9,236) or XX (8,721). In 4 of 32 cases in which the fetal sex was reportedly discordant between noninvasive prenatal testing and karyotype or ultrasonogram, a potential biological reason for the discordance exists, including two cases of documented co-twin demise, one case of a maternal kidney transplant from a male donor, and one case of fetal ambiguous genitalia. In the remaining 204 samples (1.1%), one of four sex chromosome aneuploidies (monosomy X, XXX, XXY, or XYY) was detected. The frequency of false positive results for sex chromosome aneuploidies is a minimum of 0.26% and a maximum of 1.05%. All but one of the discordant sex chromosome aneuploidy results involved the X chromosome. In two putative false-positive XXX cases, maternal XXX was confirmed by karyotype. For the false-positive cases, mean maternal age was significantly higher in monosomy X (P<.001) and lower in XXX (P=.008). Noninvasive prenatal testing results for sex chromosome aneuploidy can be confounded by maternal or fetal biological phenomena. When a discordant noninvasive prenatal testing result is encountered, resolution requires additional maternal history, detailed fetal ultrasonography, and determination of fetal and possibly maternal karyotypes.

Through-thickness recrystallization characteristics of a laminated AA3xxx–AA6xxx aluminum alloy system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liao, L.H., E-mail: l2liao@uwaterloo.ca; Jin, H.; Gallerneault, M.

2015-03-15

The through-thickness annealing behavior of a laminated AA3xxx–AA6xxx alloy system at 300 °C has been studied by scanning electron microscopy, electron backscatter diffraction analysis, electron probe micro-analysis, differential scanning calorimetry, and hardness measurement. Results show that the recrystallization process starts at the interface region between the AA3xxx (clad) and AA6xxx (core) layers. Subsequently, the recrystallization process front progresses into the core layer, while the clad layer is the last region to recrystallize. It is also found that precipitation precedes recrystallization in the entire laminate at the investigated temperature. The preferential onset of recrystallization at the interface region is attributed tomore » the net driving pressure being the highest in this region. The factors that lead to such enhanced net driving pressure are (a) deformation incompatibility between the two alloy layers, (b) lower solute content of the interface, which also leads to lower volume fraction of precipitates, and (c) an accelerated rate of precipitate coarsening due to the presence of a higher density of dislocations. The gradual progress of recrystallization from the interface towards the core layer is dictated by precipitate coarsening and the dependence of its rate on the density of deformation-induced dislocations. The lower driving pressure due to lower work hardening capacity, high solute drag pressure due to Mn, and additional Zener drag from precipitates that form due to solute redistribution during annealing explain the late initiation of recrystallization in the clad layer. - Highlights: • The through-thickness recrystallization of a laminated system is investigated. • The early onset of recrystallization at the interface is discussed. • The effects of precipitation and coarsening on recrystallization are analyzed.« less

Attention-deficit hyperactivity disorder symptoms in children and adolescents with sex chromosome aneuploidy: XXY, XXX, XYY, and XXYY.

PubMed

Tartaglia, Nicole R; Ayari, Natalie; Hutaff-Lee, Christa; Boada, Richard

2012-05-01

Attentional problems, hyperactivity, and impulsivity have been described as behavioral features associated with sex chromosome aneuploidy (SCA). In this study, the authors compare attention-deficit hyperactivity disorder (ADHD) symptoms in 167 participants aged 6 to 20 years with 4 types of SCA (XXY n = 56, XYY n = 33, XXX n = 25, and XXYY n = 53). They also evaluate factors associated with ADHD symptomatology (cognitive and adaptive scores, prenatal vs postnatal ascertainment) and describe the clinical response to psychopharmacologic medications in a subset of patients treated for ADHD. Evaluation included medical and developmental history, cognitive and adaptive functioning assessment, and parent and teacher ADHD questionnaires containing DSM-IV criteria. In the total study group, 58% (96/167) met DSM-IV criteria for ADHD on parent-report questionnaires (36% in XXY, 52% in XXX, 76% in XYY, and 72% in XXYY). The Inattentive subtype was most common in XXY and XXX, whereas the XYY and XXYY groups were more likely to also have hyperactive/impulsive symptoms. There were no significant differences in Verbal, Performance, or Full Scale IQ between children with symptom scores in the ADHD range compared with those below the ADHD range. However, adaptive functioning scores were significantly lower in the group whose scores in the ADHD range were compared with those of the group who did not meet ADHD DSM-IV criteria. Those with a prenatal diagnosis of XXY were less likely to meet criteria for ADHD compared with the postnatally diagnosed group. Psychopharmacologic treatment with stimulants was effective in 78.6% (66/84). Children and adolescents with SCA are at increased risk for ADHD symptoms. Recommendations for ADHD evaluation and treatment in consideration of other aspects of the SCA medical and behavioral phenotype are provided.

Attention-Deficit Hyperactivity Disorder Symptoms in Children and Adolescents with Sex Chromosome Aneuploidy: XXY, XXX, XYY, and XXYY

PubMed Central

Tartaglia, Nicole R.; Ayari, Natalie; Hutaff-Lee, Christa; Boada, Richard

2012-01-01

Objective Attentional problems, hyperactivity, and impulsivity have been described as behavioral features associated with sex chromosome aneuploidy (SCA). In this study, the authors compare attention-deficit hyperactivity disorder (ADHD) symptoms in 167 participants aged 6 to 20 years with 4 types of SCA (XXY n = 56, XYY n = 33, XXX n = 25, and XXYY n = 53). They also evaluate factors associated with ADHD symptomatology (cognitive and adaptive scores, prenatal vs postnatal ascertainment) and describe the clinical response to psychopharmacologic medications in a subset of patients treated for ADHD. Methods Evaluation included medical and developmental history, cognitive and adaptive functioning assessment, and parent and teacher ADHD questionnaires containing DSM-IV criteria. Results In the total study group, 58% (96/167) met DSM-IV criteria for ADHD on parent-report questionnaires (36% in XXY, 52% in XXX, 76% in XYY, and 72% in XXYY). The Inattentive subtype was most common in XXY and XXX, whereas the XYY and XXYY groups were more likely to also have hyperactive/impulsive symptoms. There were no significant differences in Verbal, Performance, or Full Scale IQ between children with symptom scores in the ADHD range compared with those below the ADHD range. However, adaptive functioning scores were significantly lower in the group whose scores in the ADHD range were compared with those of the group who did not meet ADHD DSMIV criteria. Those with a prenatal diagnosis of XXY were less likely to meet criteria for ADHD compared with the postnatally diagnosed group. Psychopharmacologic treatment with stimulants was effective in 78.6% (66/84). Conclusions Children and adolescents with SCA are at increased risk for ADHD symptoms. Recommendations for ADHD evaluation and treatment in consideration of other aspects of the SCA medical and behavioral phenotype are provided. PMID:22333574

Static Recovery Modeling of Dislocation Density in a Cold Rolled Clad Aluminum Alloy

NASA Astrophysics Data System (ADS)

Penlington, Alex

Clad alloys feature one or more different alloys bonded to the outside of a core alloy, with non-equilibrium, interalloy interfaces. There is limited understanding of the recovery and recrystallization behaviour of cold rolled clad aluminum alloys. In order to optimize the properties of such alloys, new heat treatment processes may be required that differ from what is used for the monolithic alloys. This study examines the recovery behaviour of a cold rolled Novelis Fusion(TM) alloy containing an AA6XXX core with an AA3003 cladding on one side. The bond between alloys appears microscopically discrete and continuous, but has a 30 microm wide chemical gradient. The as-deformed structure at the interalloy region consists of pancaked sub-grains with dislocations at the misorientation boundaries and a lower density organized within the more open interiors. X-ray line broadening was used to extract the dislocation density from the interalloy region and an equivalently deformed AA6XXX following static annealing using a modified Williamson-Hall analysis. This analysis assumed that Gaussian broadening contributions in a pseudo-Voigt function corresponded only to strain from dislocations. The kinetics of the dislocation density evolution to recrystallization were studied isothermally at 2 minute intervals, and isochronally at 175 and 205°C. The data fit the Nes model, in which the interalloy region recovered faster than AA6XXX at 175°C, but was slower at 205°C. This was most likely caused by change in texture and chemistry within this region such as over-aging of AA6XXX . Simulation of a continuous annealing and self homogenization process both with and without pre-recovery indicates a detectable, though small change in the texture and grain size in the interalloy region.

Fleet Maintenance Simulation With Insufficient Data

DTIC Science & Technology

2010-03-17

Maintenance in CBM UL ddd ≤≤ UL XXX µµµ ≤≤ UL XXX σσσ ≤≤ s. t. ( ) ( )MtMcR tRtF −≤ 1 ,, Xd ( ) tLML CrtC ≤,,,, XX σµd Time S y s t e m R e l i a b i...ApprovedOMB No. 0704-0188 Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for...comply with a collection of information if it does not display a currently valid OMB control number. 1 . REPORT DATE 17 MAR 2010 2. REPORT TYPE Briefing

Remarks towards the spectrum of the Heisenberg spin chain type models

NASA Astrophysics Data System (ADS)

Burdík, Č.; Fuksa, J.; Isaev, A. P.; Krivonos, S. O.; Navrátil, O.

2015-05-01

The integrable close and open chain models can be formulated in terms of generators of the Hecke algebras. In this review paper, we describe in detail the Bethe ansatz for the XXX and the XXZ integrable close chain models. We find the Bethe vectors for two-component and inhomogeneous models. We also find the Bethe vectors for the fermionic realization of the integrable XXX and XXZ close chain models by means of the algebraic and coordinate Bethe ansatz. Special modification of the XXZ closed spin chain model ("small polaron model") is considered. Finally, we discuss some questions relating to the general open Hecke chain models.

Energy Levels and Radiative Rates for Transitions in F-like Sc XIII and Ne-like Sc XII and Y XXX

NASA Astrophysics Data System (ADS)

Aggarwal, Kanti

2018-05-01

Energy levels, radiative rates and lifetimes are reported for F-like Sc~XIII and Ne-like Sc~XII and Y~XXX for which the general-purpose relativistic atomic structure package ({\\sc grasp}) has been adopted. For all three ions limited data exist in the literature but comparisons have been made wherever possible to assess the accuracy of the calculations. In the present work the lowest 102, 125 and 139 levels have been considered for the respective ions. Additionally, calculations have also been performed with the flexible atomic code ({\\sc fac}) to (particularly) confirm the accuracy of energy levels.

Spectrum lines of highly ionized zinc, germanium, selenium, zirconium, molybdenum, and silver injected into Princeton Large Torus and Tokamak Fusion Test Reactor tokamak discharges

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hinnov, E.; Boody, F.; Cohen, S.

1986-10-01

Measured wavelengths of a number of highly ionized atoms are reported. These include the 3s/sup 2/3p--3s3p/sup 2/ and 3s/sup 2/3p--3s/sup 2/3d transitions in the aluminum isoelectronic sequence of Zn XVIII, Ge XX, Se XXII, Zr XXVIII, Mo XXX, and Ag XXXV; several transitions in the n = 2 shell of Zn XXII, Zn XXIII, and Zn XXIV; and the resonance and intercombination lines of Ag XXXVI--Ag XXXVII and of Ge XXIX--Ge XXX.

Klinefelter syndrome as a window on the aetiology of language and communication impairments in children: the neuroligin–neurexin hypothesis

PubMed Central

Bishop, Dorothy VM; Scerif, Gaia

2011-01-01

Aim To compare the phenotype in Klinefelter syndrome (KS) with (i) specific language impairment (SLI) and (ii) XXX and XYY trisomies. Methods Phenotypes of KS, XXX and XYY were based on data from a systematic review of neurodevelopmental outcomes plus a recent parent survey. Phenotype of SLI was based on a published survey of children attending a special school. Results There are close similarities between the KS phenotype and SLI. Furthermore, a minority of children with KS have features of autistic spectrum disorder. Similar language and communication problems are seen in the other two sex chromosome trisomies (SCTs), XXX and XYY. Conclusion We propose the neurexin–neuroligin hypothesis, based on the observation that neuroligin genes, which occur on both X and Y chromosomes, are involved in the same synaptic networks as neurexin genes with common variants that affect risk for SLI and autism. According to our hypothesis, the effect of a triple dose of neuroligin gene product will be particularly detrimental when it occurs in conjunction with specific variants of neurexin genes on other chromosomes. This speculative proposal demonstrates the potential of illuminating the aetiology of common neurodevelopmental disorders by studying children with SCTs. PMID:21418292

Singularities of the dynamical structure factors of the spin-1/2 XXX chain at finite magnetic field.

PubMed

Carmelo, J M P; Sacramento, P D; Machado, J D P; Campbell, D K

2015-10-14

We study the longitudinal and transverse spin dynamical structure factors of the spin-1/2 XXX chain at finite magnetic field h, focusing in particular on the singularities at excitation energies in the vicinity of the lower thresholds. While the static properties of the model can be studied within a Fermi-liquid like description in terms of pseudoparticles, our derivation of the dynamical properties relies on the introduction of a form of the 'pseudofermion dynamical theory' (PDT) of the 1D Hubbard model suitably modified for the spin-only XXX chain and other models with two pseudoparticle Fermi points. Specifically, we derive the exact momentum and spin-density dependences of the exponents ζ(τ)(k) controlling the singularities for both the longitudinal (τ = l) and transverse (τ = t) dynamical structure factors for the whole momentum range k ∈ ]0,π[, in the thermodynamic limit. This requires the numerical solution of the integral equations that define the phase shifts in these exponents expressions. We discuss the relation to neutron scattering and suggest new experiments on spin-chain compounds using a carefully oriented crystal to test our predictions.

Prenatal diagnosis and prognosis of triple X syndrome: 47, XXX.

PubMed

Ben Hamouda, H; Mkacher, N; Elghezal, H; Bannour, H; Kamoun, M; Soua, H; Saad, A; Souissi, M M; Sfar, M T

2009-11-01

Triple X syndrome is a relatively common sex chromosomal abnormality occurring in 0,1% of live-born female infants. Most of these infants have a normal phenotype and only a few cases with 47, XXX karyotype have congenital malformations. We report three cases of triple X syndrome that were diagnosed prenatally by genetic amniocentesis for advanced maternal age and have been observed from birth to age of 3 to 12 years. A description of their growth and development is presented. The birth weight was normal in all patients and one of them had facial dysmorphism with right microphtalmia and auricular septal defect. During the first 2 years of life, the neuromotor development of these infants was not distinguishable from chromosomally normal children. By 3 years of age, two patients have a moderate developmental delay in speech and language. One girl 12-year-old had normal schooling. The diagnosis of the triple X syndrome can be never made because clinical demonstrations are not rather important to arouse the demand of a karyotype. Prenatal diagnosis is often made in front of the advanced maternal age. Expectant parents must be counseled as to the significance of this 47, XXX karyotype and prognostic information must be given.

Characterization and Evolutionary Implications of the Triad Asp-Xxx-Glu in Group II Phosphopantetheinyl Transferases

PubMed Central

Wang, Yue-Yue; Li, Yu-Dong; Liu, Jian-Bo; Ran, Xin-Xin; Guo, Yuan-Yang; Ren, Ni-Ni; Chen, Xin; Jiang, Hui; Li, Yong-Quan

2014-01-01

Phosphopantetheinyl transferases (PPTases), which play an essential role in both primary and secondary metabolism, are magnesium binding enzymes. In this study, we characterized the magnesium binding residues of all known group II PPTases by biochemical and evolutionary analysis. Our results suggested that group II PPTases could be classified into two subgroups, two-magnesium-binding-residue-PPTases containing the triad Asp-Xxx-Glu and three-magnesium-binding-residue-PPTases containing the triad Asp-Glu-Glu. Mutations of two three-magnesium-binding-residue-PPTases and one two-magnesium-binding-residue-PPTase indicate that the first and the third residues in the triads are essential to activities; the second residues in the triads are non-essential. Although variations of the second residues in the triad Asp-Xxx-Glu exist throughout the whole phylogenetic tree, the second residues are conserved in animals, plants, algae, and most prokaryotes, respectively. Evolutionary analysis suggests that: the animal group II PPTases may originate from one common ancestor; the plant two-magnesium-binding-residue-PPTases may originate from one common ancestor; the plant three-magnesium-binding-residue-PPTases may derive from horizontal gene transfer from prokaryotes. PMID:25036863

Singularities of the dynamical structure factors of the spin-1/2 XXX chain at finite magnetic field

NASA Astrophysics Data System (ADS)

Carmelo, J. M. P.; Sacramento, P. D.; Machado, J. D. P.; Campbell, D. K.

2015-10-01

We study the longitudinal and transverse spin dynamical structure factors of the spin-1/2 XXX chain at finite magnetic field h, focusing in particular on the singularities at excitation energies in the vicinity of the lower thresholds. While the static properties of the model can be studied within a Fermi-liquid like description in terms of pseudoparticles, our derivation of the dynamical properties relies on the introduction of a form of the ‘pseudofermion dynamical theory’ (PDT) of the 1D Hubbard model suitably modified for the spin-only XXX chain and other models with two pseudoparticle Fermi points. Specifically, we derive the exact momentum and spin-density dependences of the exponents {{\\zeta}τ}(k) controlling the singularities for both the longitudinal ≤ft(τ =l\\right) and transverse ≤ft(τ =t\\right) dynamical structure factors for the whole momentum range k\\in ]0,π[ , in the thermodynamic limit. This requires the numerical solution of the integral equations that define the phase shifts in these exponents expressions. We discuss the relation to neutron scattering and suggest new experiments on spin-chain compounds using a carefully oriented crystal to test our predictions.

Characterization and evolutionary implications of the triad Asp-Xxx-Glu in group II phosphopantetheinyl transferases.

PubMed

Wang, Yue-Yue; Li, Yu-Dong; Liu, Jian-Bo; Ran, Xin-Xin; Guo, Yuan-Yang; Ren, Ni-Ni; Chen, Xin; Jiang, Hui; Li, Yong-Quan

2014-01-01

Phosphopantetheinyl transferases (PPTases), which play an essential role in both primary and secondary metabolism, are magnesium binding enzymes. In this study, we characterized the magnesium binding residues of all known group II PPTases by biochemical and evolutionary analysis. Our results suggested that group II PPTases could be classified into two subgroups, two-magnesium-binding-residue-PPTases containing the triad Asp-Xxx-Glu and three-magnesium-binding-residue-PPTases containing the triad Asp-Glu-Glu. Mutations of two three-magnesium-binding-residue-PPTases and one two-magnesium-binding-residue-PPTase indicate that the first and the third residues in the triads are essential to activities; the second residues in the triads are non-essential. Although variations of the second residues in the triad Asp-Xxx-Glu exist throughout the whole phylogenetic tree, the second residues are conserved in animals, plants, algae, and most prokaryotes, respectively. Evolutionary analysis suggests that: the animal group II PPTases may originate from one common ancestor; the plant two-magnesium-binding-residue-PPTases may originate from one common ancestor; the plant three-magnesium-binding-residue-PPTases may derive from horizontal gene transfer from prokaryotes.

47,XXX/45,X/46,XX mosaicism in a patient with Turner phenotype and spontaneous puberal development.

PubMed

Brambila-Tapia, Aniel Jessica Leticia; Rivera, Horacio; García-Castillo, Herbert; Domínguez-Quezada, Maria Guadalupe; Dávalos-Rodríguez, Ingrid Patricia

2009-11-01

To describe a patient with infertility and phenotypic combination of Turner and triple-X syndrome related to mos 47,XXX/45X/46,XX karyotype. Case report. División de Genética, Centro de Investigación Biomédica de Occidente and Hospital de Ginecología y Obstetricia, CMNO, Instituto Mexicano del Seguro Social. The 24-year-old patient presented a phenotypic combination of Turner syndrome and X polysomy. She showed wide and short neck, low posterior hairline, cubitus valgus, bilateral shortening of the fourth and fifth metacarpals, multiple nevi, and müllerian anomalies but had spontaneous pubarche, thelarche, and menarche. Laboratory evaluations, imaging studies, ovarian biopsy, G-banding karyotype, and in situ fluorescence hybridization. Clinical and laboratory findings. A karyotype: mos 47,XXX/45X/46,XX was found in the cytogenetic studies, a bicornuate uterus in the ultrasonographic scan, and a normal ovarian profile in the laboratory tests. The infertility in the present case can be related to either bicornuate uterus or subclinical abortions due to aneuploid ova. Cytogenetic assessment provides important information regarding infertile patients with uterine factors and short stature.

Atomic structure calculations and identification of EUV and SXR spectral lines in Sr XXX

NASA Astrophysics Data System (ADS)

Goyal, Arun; Khatri, Indu; Aggarwal, Sunny; Singh, A. K.; Mohan, Man

2015-08-01

We report an extensive theoretical study of atomic data for Sr XXX in a wide range with L-shell electron excitations to the M-shell. We have calculated energy levels, wave-function compositions and lifetimes for lowest 113 fine structure levels and wavelengths of an extreme Ultraviolet (EUV) and soft X-ray (SXR) transitions. We have employed multi-configuration Dirac Fock method (MCDF) approach within the framework of Dirac-Coulomb Hamiltonian including quantum electrodynamics (QED) and Breit corrections. We have also presented the radiative data for electric and magnetic dipole (E1, M1) and quadrupole (E2, M2) transitions from the ground state. We have made comparisons with available energy levels compiled by NIST and achieve good agreement. But due to inadequate data in the literature, analogous relativistic distorted wave calculations have also been performed using flexible atomic code (FAC) to assess the reliability and accuracy of our results. Additionally, we have provided new atomic data for Sr XXX which is not published elsewhere in the literature and we believe that our results may be beneficial in fusion plasma research and astrophysical investigations and applications.

Influence of secondary structure on in-source decay of protein in matrix-assisted laser desorption/ionization mass spectrometry.

PubMed

Takayama, Mitsuo; Osaka, Issey; Sakakura, Motoshi

2012-01-01

The susceptibility of the N-Cα bond of the peptide backbone to specific cleavage by in-source decay (ISD) in matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) was studied from the standpoint of the secondary structure of three proteins. A naphthalene derivative, 5-amino-1-naphtol (5,1-ANL), was used as the matrix. The resulting c'-ions, which originate from the cleavage at N-Cα bonds in flexible secondary structures such as turn and bend, and are free from intra-molecular hydrogen-bonded α-helix structure, gave relatively intense peaks. Furthermore, ISD spectra of the proteins showed that the N-Cα bonds of specific amino acid residues, namely Gly-Xxx, Xxx-Asp, and Xxx-Asn, were more susceptible to MALDI-ISD than other amino acid residues. This is in agreement with the observation that Gly, Asp and Asn residues usually located in turns, rather than α-helix. The results obtained indicate that protein molecules embedded into the matrix crystal in the MALDI experiments maintain their secondary structures as determined by X-ray crystallography, and that MALDI-ISD has the capability for providing information concerning the secondary structure of protein.

Status of Standardization Projects

DTIC Science & Technology

1992-03-31

50 SS N D 8915 TOTAL- 1. DELINQUENT- 0, STATUS CODES: A- 1, G- 0, Y- 0, Z- 0 8920 0539 MIL R 35084A RICE INSTANT ENRICHED GL G2 903 913 913 A GL SA 50...G XXX GL GINGERBREAD PWDER FOLF GL B4 922 932 932 A GL N 8940 A731 IMIL P XXX GL PORK ORIENTAL WITH NOODLES GL B4 922 932 932 A GL N 8940 A732 MIL R... INSTANT GL 84 A 893 903 922 A GL SA 50 SS U B 8955 TOTAL- 1. DELINQUENT- 1, STATUS CODES: A- 1, G- 0, Y- 0. Z- 0 8960 0077 MIL C 3031J 1 COCOA BEVERAGE

Near Net Manufacturing Using Thin Gage Friction Stir Welding

NASA Technical Reports Server (NTRS)

Takeshita, Jennifer; Potter, David; Holquin, Michael

2006-01-01

Friction Stir Welding (FSW) and near net spin forming of FSW aluminumn blanks were investigated for large-scale pressure vessel applications. With a specific focus on very thin gage 2xxx and 7xxx aluminum alloys, the program concentrated on the following: the criteria used for material selection, a potential manufacturing flow, and the effectiveness and associated risks of near net spin forming. Discussion will include the mechanical properties of the friction stir welds and the parent material from before and after the spin forming process. This effort was performed under a NASA Space Exploration initiative focused on increasing the affordability, reliability and performance of pressure vessels larger than 10 ft. diameter.

Algebraic Bethe ansatz for the XXX chain with triangular boundaries and Gaudin model

NASA Astrophysics Data System (ADS)

Cirilo António, N.; Manojlović, N.; Salom, I.

2014-12-01

We implement fully the algebraic Bethe ansatz for the XXX Heisenberg spin chain in the case when both boundary matrices can be brought to the upper-triangular form. We define the Bethe vectors which yield the strikingly simple expression for the off shell action of the transfer matrix, deriving the spectrum and the relevant Bethe equations. We explore further these results by obtaining the off shell action of the generating function of the Gaudin Hamiltonians on the corresponding Bethe vectors through the so-called quasi-classical limit. Moreover, this action is as simple as it could possibly be, yielding the spectrum and the Bethe equations of the Gaudin model.

45,X/47,XXX Mosaicism and Short Stature.

PubMed

Everest, Erica; Tsilianidis, Laurie A; Haider, Anzar; Rogers, Douglas G; Raissouni, Nouhad; Schweiger, Bahareh

2015-01-01

We describe the case of a ten-year-old girl with short stature and 45,X/47,XXX genotype. She also suffered from vesicoureteric reflux and kidney dysfunction prior to having surgery on her ureters. Otherwise, she does not have any of the characteristics of Turner nor Triple X syndrome. It has been shown that this mosaic condition as well as other varieties creates a milder phenotype than typical Turner syndrome, which is what we mostly see in our patient. However, this patient is a special case, because she is exceptionally short. Overall, one cannot predict the resultant phenotype in these mosaic conditions. This creates difficulty in counseling parents whose children or fetuses have these karyotypes.

45,X/47,XXX Mosaicism and Short Stature

PubMed Central

Tsilianidis, Laurie A.; Haider, Anzar; Rogers, Douglas G.; Schweiger, Bahareh

2015-01-01

We describe the case of a ten-year-old girl with short stature and 45,X/47,XXX genotype. She also suffered from vesicoureteric reflux and kidney dysfunction prior to having surgery on her ureters. Otherwise, she does not have any of the characteristics of Turner nor Triple X syndrome. It has been shown that this mosaic condition as well as other varieties creates a milder phenotype than typical Turner syndrome, which is what we mostly see in our patient. However, this patient is a special case, because she is exceptionally short. Overall, one cannot predict the resultant phenotype in these mosaic conditions. This creates difficulty in counseling parents whose children or fetuses have these karyotypes. PMID:26137340

The Turner syndrome in patient with 45X/47XXX mosaic karyotype--case report.

PubMed

Maciejewska-Jeske, Marzena; Czyzyk, Adam; Meczekalski, Blazej

2015-07-01

Turner syndrome (TS) is a gonadal dysgenesis related to partial or total lack of one of the X chromosomes. It this report we describe a young patient presenting some somatic features of TS, who underwent spontaneous puberty and was eumenoorheic up to the age of 23. Using fluorescent in situ hybridization (FISH) mosaic karyotype (45X[131]/47XXX[9]) of TS and triple X syndrome was found. She presented uncommon for TS somatic hemihypotrophy and underwent growth hormone and surgical therapy. The patient was diagnosed with premature ovarian failure when she was 23, with absent follicular reserve. Clinical features of this case and a few published cases will be reviewed briefly.

Evolution of microstructure and precipitates in 2xxx aluminum alloy after severe plastic deformation

NASA Astrophysics Data System (ADS)

Adamczyk-Cieslak, B.; Zdunek, J.; Mizera, J.

2016-04-01

This paper investigates the influence of precipitation on the microstructure development in a 2xxx aluminum alloy subjected to hydrostatic extrusion. A three step reduction of the diameter was performed using hydrostatic extrusion (HE) process: from 20mm (initial state) to 10 mm, 5 mm and 3 mm, which corresponds to the logarithmic deformations ɛ = 1.4, ɛ = 2.8 and ɛ = 3.8 respectively. The microstructure and precipitation analysis before and after deformation was performed using transmission electron microscope (TEM), and scanning electron microscopy (SEM). As a result of the tests, a very significant influence of precipitation on the degree of refinement and mechanism of microstructure transformation was stated.

Fires in storages of LFO: Analysis of hazard of structural collapse of steel-aluminium containers.

PubMed

Rebec, A; Kolšek, J; Plešec, P

2016-04-05

Pool fires of light fuel oil (LFO) in above-ground storages with steel-aluminium containers are discussed. A model is developed for assessments of risks of between-tank fire spread. Radiative effects of the flame body are accounted for by a solid flame radiation model. Thermal profiles evolved due to fire in the adjacent tanks and their consequential structural response is pursued in an exact (materially and geometrically non-linear) manner. The model's derivation is demonstrated on the LFO tank storage located near the Port of Koper (Slovenia). In support of the model, data from literature are adopted where appropriate. Analytical expressions are derived correspondingly for calculations of emissive characteristics of LFO pool fires. Additional data are collected from experiments. Fire experiments conducted on 300cm diameter LFO pans and at different wind speeds and high-temperature uniaxial tension tests of the analysed aluminium alloys types 3xxx and 6xxx are presented. The model is of an immediate fire engineering practical value (risk analyses) or can be used for further research purposes (e.g. sensitivity and parametric studies). The latter use is demonstrated in the final part of the paper discussing possible effects of high-temperature creep of 3xxx aluminium. Copyright © 2015 Elsevier B.V. All rights reserved.

Flexible Xxx–Asp/Asn and Gly–Xxx Residues of Equine Cytochrome c in Matrix-Assisted Laser Desorption/Ionization In-Source Decay Mass Spectrometry

PubMed Central

Takayama, Mitsuo

2012-01-01

The backbone flexibility of a protein has been studied from the standpoint of the susceptibility of amino acid residues to in-source decay (ISD) in matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS). Residues more susceptible to MALDI-ISD, namely Xxx–Asp/Asn and Gly–Xxx, were identified from the discontinuous intense peak of c′-ions originating from specific cleavage at N–Cα bonds of the backbone of equine cytochrome c. The identity of the residues susceptible to ISD was consistent with the known flexible backbone amides as estimated by hydrogen/deuterium exchange (HDX) experiments. The identity of these flexible amino acid residues (Asp, Asn, and Gly) is consistent with the fact that these residues are preferred in flexible secondary structure free from intramolecular hydrogen-bonded structures such as α-helix and β-sheet. The MALDI-ISD spectrum of equine cytochrome c gave not only intense N-terminal side c′-ions originating from N–Cα bond cleavage at Xxx–Asp/Asn and Gly–Xxx residues, but also C-terminal side complement z′-ions originating from the same cleavage sites. The present study implies that MALDI-ISD can give information about backbone flexibility of proteins, comparable with the protection factors estimated by HDX. PMID:24349908

Neurocognitive outcomes of individuals with a sex chromosome trisomy: XXX, XYY, or XXY: a systematic review*

PubMed Central

LEGGETT, VICTORIA; JACOBS, PATRICIA; NATION, KATE; SCERIF, GAIA; BISHOP, DOROTHY V M

2010-01-01

Aim To review systematically the neurodevelopmental characteristics of individuals with sex chromosome trisomies (SCTs). Method A bibliographic search identified English-language articles on SCTs. The focus was on studies unbiased by clinical referral, with power of at least 0.69 to detect an effect size of 1.0. Results We identified 35 articles on five neonatally identified samples that had adequate power for our review. An additional 11 studies were included where cases had been identified for reasons other than neurodevelopmental concerns. Individuals with an additional X chromosome had mean IQs that were within broadly normal limits but lower than the respective comparison groups, with verbal IQ most affected. Cognitive outcomes were poorest for females with XXX. Males with XYY had normal-range IQs, but all three SCT groups (XXX, XXY, and XYY) had marked difficulties in speech and language, motor skills, and educational achievement. Nevertheless, most adults with SCTs lived independently. Less evidence was available for brain structure and for attention, social, and psychiatric outcomes. Within each group there was much variation. Interpretation Individuals with SCTs are at risk of cognitive and behavioural difficulties. However, the evidence base is slender, and further research is needed to ascertain the nature, severity, and causes of these difficulties in unselected samples. PMID:20059514

Excited state correlations of the finite Heisenberg chain

NASA Astrophysics Data System (ADS)

Pozsgay, Balázs

2017-02-01

We consider short range correlations in excited states of the finite XXZ and XXX Heisenberg spin chains. We conjecture that the known results for the factorized ground state correlations can be applied to the excited states too, if the so-called physical part of the construction is changed appropriately. For the ground state we derive simple algebraic expressions for the physical part; the formulas only use the ground state Bethe roots as an input. We conjecture that the same formulas can be applied to the excited states as well, if the exact Bethe roots of the excited states are used instead. In the XXZ chain the results are expected to be valid for all states (except certain singular cases where regularization is needed), whereas in the XXX case they only apply to singlet states or group invariant operators. Our conjectures are tested against numerical data from exact diagonalization and coordinate Bethe Ansatz calculations, and perfect agreement is found in all cases. In the XXX case we also derive a new result for the nearest-neighbour correlator < σ 1zσ 2z> , which is valid for non-singlet states as well. Our results build a bridge between the known theory of factorized correlations, and the recently conjectured TBA-like description for the building blocks of the construction.

Patients with 47, XXX karyotype who experienced premature ovarian failure (POF): two case reports.

PubMed

Sugawara, Nobuo; Maeda, Machiko; Manome, Tomomi; Nagai, Rie; Araki, Yasuhisa

2013-10-01

Pubertal onset and sexual development are usually normal in 47, XXX individuals; however, we report two cases of premature ovarian failure (POF) in infertile women with trisomy X. Chromosome analysis was conducted with G-banding and fluorescence in situ hybridization using X- and Y-bearing probe. Hormonal administration was primarily Kaufmann's treatment or long-term estradiol treatment, followed by withdrawal bleeding from estrogen and progesterone. Two patients with trisomy X, aged 31 (patient 1) and 27 years (patient 2), were diagnosed with POF due to hypergonadotropic hypogonadism. Their ovaries were small. Patient 1 had a FSH level of 44.6 mIU/ml and patient 2 had a FSH level of 74.6 mIU/ml. In patient 1, with Kaufmann's treatment, the FSH decreased to 13.5 mIU/ml; however, follicle growth did not occur following HMG stimulation. In patient 2, FSH did not decrease despite Kaufmann's treatment; therefore, she was given a GnRH agonist and her FSH level decreased to 7.1 mIU/ml. However, her ovaries never responded to HMG stimulation. We report on two patients with a 47, XXX karyotype who became infertile due to POF. We recommend that when a patient is diagnosed with trisomy X, the possibility of POF must be strongly considered.

Neurocognitive outcomes of individuals with a sex chromosome trisomy: XXX, XYY, or XXY: a systematic review.

PubMed

Leggett, Victoria; Jacobs, Patricia; Nation, Kate; Scerif, Gaia; Bishop, Dorothy V M

2010-02-01

To review systematically the neurodevelopmental characteristics of individuals with sex chromosome trisomies (SCTs). A bibliographic search identified English-language articles on SCTs. The focus was on studies unbiased by clinical referral, with power of at least 0.69 to detect an effect size of 1.0. We identified 35 articles on five neonatally identified samples that had adequate power for our review. An additional 11 studies were included where cases had been identified for reasons other than neurodevelopmental concerns. Individuals with an additional X chromosome had mean IQs that were within broadly normal limits but lower than the respective comparison groups, with verbal IQ most affected. Cognitive outcomes were poorest for females with XXX. Males with XYY had normal-range IQs, but all three SCT groups (XXX, XXY, and XYY) had marked difficulties in speech and language, motor skills, and educational achievement. Nevertheless, most adults with SCTs lived independently. Less evidence was available for brain structure and for attention, social, and psychiatric outcomes. Within each group there was much variation. Individuals with SCTs are at risk of cognitive and behavioural difficulties. However, the evidence base is slender, and further research is needed to ascertain the nature, severity, and causes of these difficulties in unselected samples.

Acromegaly accompanied by Turner syndrome with 47,XXX/45,X/46,XX mosaicism.

PubMed

Yamazaki, Masanori; Sato, Ai; Nishio, Shin-ichi; Takeda, Teiji; Miyamoto, Takahide; Katai, Miyuki; Hashizume, Kiyoshi

2009-01-01

A 33-year-old woman was hospitalized for examination of edematous laryngopharynx. She was acromegalic. A pituitary adenoma with elevated serum levels of growth hormone (GH) and insulin-like growth factor-I (IGF-I) was detected, indicating acromegaly caused by GH-secreting pituitary adenoma. Multiple pigmented nevi were also noted without overt short stature and cubitus valgus. Chromosome analysis revealed that she had contracted Turner syndrome with 47,XXX/45,X/46,XX mosaicism. Transsphenoidal resection of the tumor decreased serum GH and IGF-I levels, but the edema was not improved. Both premature ovarian failure and hypertension appeared after surgery. This case may indicate the important relationships between GH/IGF-I and Turner syndrome.

Double trisomy (XXX+21 karyotype) in a six-year-old girl with down phenotype.

PubMed

Vergara-Mendez, Laura Daniela; Talero-Gutiérrez, Claudia; Velez-Van-Meerbeke, Alberto

2018-03-01

We describe a case of a six-year-old girl who presents multiple dysmorphic features characteristic of Down's syndrome. She has a significant general developmental delay, with a score that correspond to 32 months of developmental age. This delay is especially in language, with a very scant vocabulary. She communicates with some hand sign words or pointing, although her auditory responses in hearing test were normal. Two previous karyotype studies showed 47, XXX, +21 anomalies. This double trisomy is a rare condition described in isolated cases in the literature and none of these refers to the developmental aspects of these children (Balwan et al. 2008; Li et al. 2004; Park et al. 1995; Day et al. 1963).

[Penta-X syndrome. Report of a case with 47,XXX/48,XXXX/49,XXXXX mosaicism].

PubMed

Gómez-Valencia, L; Nájera-Martínez, P; Morales-Hernández, A; Martínez-Díaz De León, A

1989-06-01

A two year five months old girl is presented with chromosomic complement 47,XXX/48,XXXX/49,XXXXX and presence of 2, 3 and 4 corpuscles in the nuclei of epithelial cells of oral mucosa. It is clinically characterized by short stature, mental retardation, generalized hypotony, bilateral elbow sub-luxation, mesotaurodontism and patent ductus arteriosus. The comparison of the clinical findings between the reported mosaics and the present case indicate the dealing with a specific pattern, recognizable clinically. In the etiologic analysis of this disease the review of pertinent literature suggests the occurrence of successive non-disjunction of the chromosomes X in more than one postzygotic divisions originating more than two stem-cell lines.

[Medicopsychosocial syndrome of polygonosomies (XXX, XXY, XYY, syndromes etc...)].

PubMed

Benezech, M; Bourgeois, M

1976-01-01

This is an attempt to describe a common syndrom of polygonosomy. Medical, psychological and social incidences of XXX, XXY, XYY, genotypes indicate that these chromosomal aberrations share identical features: phenotypic abnormalities (high stature, dermatoglyphes abnormalities), neuropsychic troubles (neurological symptoms and mental fragility) and antisocial tendancy. One can suppose that at least some polygonosomic persons have a minimal brain dysfunction (or damage), which causes more vulnerability to environnement, deprivation and stress. Relational, educational and socio-economical factors appear now to have a marked role in the etiopathogenesis of these psychiatric troubles. Some forensic and ethical problems of human genetic research are reviewed, such as the so-called "criminal chromosome", supplementary Y chromosome, a myth based upon false and premature scientific assertions.

Prenatal diagnosis of sex chromosome abnormalities: the 8-year experience of a single medical center.

PubMed

Vaknin, Zvi; Reish, Orit; Ben-Ami, Ido; Heyman, Eli; Herman, Arie; Maymon, Ron

2008-01-01

To assess the indications for prenatal karyotyping of sex chromosomal abnormalities (SCAs) during pregnancy. All singleton pregnancies interrupted in our institute because of SCAs (1998-2005) were categorized into subgroups of 45,XO (Turner syndrome), 47,XXY (Klinefelter syndrome), 47,XXX and 47,XYY. The indications for prenatal diagnostic testing were recorded. There were 67 SCAs pregnancies: 33% Turner syndrome, 28% Klinefelter syndrome, 21% 47,XXX and 18% 47,XYY. Maternal age was similar among the 4 groups (34 +/- 5, range 25-42 years). The main indications for fetal karyotyping were abnormal Down's syndrome (DS) screening or ultrasound findings, advanced maternal age (> or =35 years), and parental request. About 2/3 of the Turner and 47,XYY cases had either abnormal DS screening tests or sonographic findings, such as: increased nuchal translucency, mainly cystic hygroma and fetal hydrops. However, fetal karyotyping in more than 2/3 of the 47,XXX and 47,XXY cases was mainly performed because of advanced maternal age, and the diagnosis of fetal SCAs was coincidental (p <0.03). Our recent suggestion to expand the DS screening capacity to other chromosomal abnormalities including SCAs is further supported. Prenatal detection seems to be promising for Turner syndrome and possibly for 47,XYY syndrome, while other SCAs are less likely to be detected either by ultrasound or biochemical screening. (c) 2007 S. Karger AG, Basel

Peptides containing internal residues of pyroglutamic acid: proton NMR characteristics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khan, S.A.

1986-05-01

The proton NMR characteristics of internal pyroglutamic acid (Glp; 5-oxoproline) residues in seven tripeptides of the general structure Boc-Xxx-Glp-Yyy-NH/sub 2/ were studied. In general, the chemical shifts of several diagnostic protons moved downfield on going from the Glu-containing peptides (Boc-Xxx-Glu-Yyy-NH/sub 2/) to the corresponding Glp-containing peptides. The C-2 proton of the Xxx residue was shifted by about 1.1 ppm. The N-2 proton of the Yyy residue was shifted by about 0.5 ppm. The C-2 proton of the Glx residue itself was shifted by about 0.5 ppm. One of the Glx C-3 protons was also shifted by about 0.5 ppm, butmore » the other remained essentially unchanged. Finally, the Glx C-4 protons were shifted by about 0.3 ppm. Internal Glu residues are readily converted chemically into internal Glp residues. This conversion also occurs as a side reaction during HP cleavage of the protecting group from Glu(OBzl) residues. The spontaneous fragmentation of serum proteins C3, C4 and lambda/sub 2/-macroglobulin under denaturing conditions is probably due to regioselective hydrolysis of an internal Glp residue formed in each of these proteins upon denaturation. These proton NMR characteristics may be useful in establishing the presence of internal Glp residues in synthetic and natural peptides.« less

Algebraic Bethe ansatz for the XXZ Heisenberg spin chain with triangular boundaries and the corresponding Gaudin model

NASA Astrophysics Data System (ADS)

Manojlović, N.; Salom, I.

2017-10-01

The implementation of the algebraic Bethe ansatz for the XXZ Heisenberg spin chain in the case, when both reflection matrices have the upper-triangular form is analyzed. The general form of the Bethe vectors is studied. In the particular form, Bethe vectors admit the recurrent procedure, with an appropriate modification, used previously in the case of the XXX Heisenberg chain. As expected, these Bethe vectors yield the strikingly simple expression for the off-shell action of the transfer matrix of the chain as well as the spectrum of the transfer matrix and the corresponding Bethe equations. As in the XXX case, the so-called quasi-classical limit gives the off-shell action of the generating function of the corresponding trigonometric Gaudin Hamiltonians with boundary terms.

The role of calcium and predation on plate morph evolution in the three-spined stickleback (Gasterosteus aculeatus).

PubMed

Smith, Carl; Spence, Rowena; Barber, Iain; Przybylski, Mirosław; Wootton, Robert J

2014-09-01

While the genetic basis to plate morph evolution of the three-spined stickleback (Gasterosteus aculeatus) is well described, the environmental variables that select for different plate and spine morphs are incompletely understood. Using replicate populations of three-spined sticklebacks on North Uist, Scotland, we previously investigated the role of predation pressure and calcium limitation on the adaptive evolution of stickleback morphology and behavior. While dissolved calcium proved a significant predictor of plate and spine morph, predator abundance did not. Ecol. Evol., xxx, 2014 and xxx performed a comparable analysis to our own to address the same question. They failed to detect a significant effect of dissolved calcium on morphological evolution, but did establish a significant effect of predation; albeit in the opposite direction to their prediction.

Culturally Responsive Pain Management for Black Older Adults.

PubMed

Robinson-Lane, Sheria G; Booker, Staja Q

2017-03-02

HOW TO OBTAIN CONTACT HOURS BY READING THIS ARTICLE INSTRUCTIONS XX contact hours will be awarded by Villanova University College of Nursing upon successful completion of this activity. A contact hour is a unit of measurement that denotes 60 minutes of an organized learning activity. This is a learner-based activity. Villanova University College of Nursing does not require submission of your answers to the quiz. A contact hour certificate will be awarded once you register, pay the registration fee, and complete the evaluation form online at http://goo.gl/gMfXaf. To obtain contact hours you must: 1. Read the article, "XXXX XXXX XXXXXX XXXXXXX XXXX XXXX XXX XXX XXXX XX" found on pages XX-XX, carefully noting any tables and other illustrative materials that are included to enhance your knowledge and understanding of the content. Be sure to keep track of the amount of time (number of minutes) you spend reading the article and completing the quiz. 2. Read and answer each question on the quiz. After completing all of the questions, compare your answers to those provided within this issue. If you have incorrect answers, return to the article for further study. 3. Go to the Villanova website listed above to register for contact hour credit. You will be asked to provide your name; contact information; and a VISA, MasterCard, or Discover card number for payment of the $20.00 fee. Once you complete the online evaluation, a certificate will be automatically generated. This activity is valid for continuing education credit until MONTH XX, 20XX. CONTACT HOURS This activity is co-provided by Villanova University College of Nursing and SLACK Incorporated. Villanova University College of Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation. ACTIVITY OBJECTIVES 1. XXX 2. XXX DISCLOSURE STATEMENT Neither the planners nor the author have any conflicts of interest to disclose. The management of pain for Black older adults has received inadequate attention by health care professionals despite evidence of greater pain intensity, depressive symptoms, and functional disability compared with White American older adults. Pain management for this population may be significantly improved with more careful attention to the provision of culturally responsive care. As professionals concerned with the optimization of health and reduction of suffering throughout the lifespan, nurses have an ethical, moral, and professional responsibility to provide culturally responsive care to the populations they serve-particularly when clear disparities in health exist. By considering how culture affects important health beliefs, values, preferences, and customs, and integrating this understanding into practice, quality of life is likely to be improved. [Journal of Gerontological Nursing, xx(x), xx-xx.]. Copyright 2017, SLACK Incorporated.

Microstructural-Scale Model for Surfaces Spreading of Intergranular Corrosion in Sensitized Stainless Steels and Aluminum-Magnesium (AA5XXX) Alloys

NASA Astrophysics Data System (ADS)

Jain, Swati

Components from AA5XXX (Al-Mg alloys with more than 3 wt% Mg) alloys are X attractive due to availability of low cost, high strength to weight ratio and good weldability. Therefore, these alloys have potential applications in Naval ships. However, these alloys become susceptible to IGC (intergranular corrosion) due to beta-phase precipitation due to improper heat treatment or inadvertent thermal exposure. Stainless steels may also become susceptible due to carbide precipitation and chromium depletion on grain boundaries. IGC susceptibility depends on the interplay between the metallurgical conditions, electrochemical conditions, and chemical conditions. Specific combinations cause IGC while others do not. The objective of this study is to investigate the conditions which bring about surface spreading of IGC in these alloy classes. To accomplish this goal, a microstructure scale model was developed with experimental inputs to understand the 2-D IGC spreading in stainless steels and AA5XXX alloys. The conditions strongly affecting IGC spreading were elucidated. Upon natural and artificial aging, the stainless steels become susceptible to intergranular corrosion because of chromium depletion in the grain boundaries. After aging Al-Mg (AA5XXX) alloys show susceptibility due to the precipitation of the beta-phase (Al3Mg7) in the grain boundaries. Chromium depleted grain boundaries in stainless steels are anodically more active as compared to the interior of the grains. (3-phase rich grain boundaries have lower OCP (open circuit potential) and pitting potentials as compared to the Al-Mg solid solutions. A new approach to modeling the IGC surface spreading in polycrystalline materials that is presented. This model is the first to couple several factors into one granular scale model that illustrates the way in which they interact and IGC occurs. It sheds new information on conditions which cause IGC spreading in two alloy classes and describes a new theory for the critical potential associated with IGC. The outcomes from this contribute to ways to advance the goal of corrosion resistant computational design of alloys, guiding mitigation strategies for suppressing IGC in existing alloys, and to damage prognosis aimed at predicting damage and structural integrity.

Genetics Home Reference: triple X syndrome

MedlinePlus

... Twitter Home Health Conditions Triple X syndrome Triple X syndrome Printable PDF Open All Close All Enable ... to view the expand/collapse boxes. Description Triple X syndrome , also called trisomy X or 47,XXX, ...

Bladder exstrophy-epispadias complex and triple-X syndrome: incidental finding or causality?

PubMed

Ramaekers, Paul; Loeys, Bart; von Lowtzow, Catharina; Reutter, Heiko; Leroy, Yves; Colpaert, Cécile; Blaumeiser, Bettina; Janssens, Katrien; Parizel, Maxim; Jacquemyn, Yves

2014-10-01

Bladder exstrophy is a rare malformation. Prenatal diagnosis is usually an incidental finding on routine ultrasound examination. Triple-X syndrome (karyotype 47,XXX) is the most frequent sex chromosome aneuploidy in live-born females (approximately 1 in 1000). The diagnosis is often not made because women with 47,XXX karyotype have no or hardly any clinical symptoms during life. Prenatal diagnosis of triple X karyotype is usually an incidental finding when an invasive prenatal diagnosis is performed for other reasons. Here, we report on two cases with bladder exstrophy and triple-X syndrome, one in a fetus and one in an adult. In view of two previous reports of this association in literature, causality of these two conditions should be considered. A gene dosage effect as possible underlying mechanisms will be discussed. © 2014 Wiley Periodicals, Inc.

The role of calcium and predation on plate morph evolution in the three-spined stickleback (Gasterosteus aculeatus)

PubMed Central

Smith, Carl; Spence, Rowena; Barber, Iain; Przybylski, Mirosław; Wootton, Robert J

2014-01-01

While the genetic basis to plate morph evolution of the three-spined stickleback (Gasterosteus aculeatus) is well described, the environmental variables that select for different plate and spine morphs are incompletely understood. Using replicate populations of three-spined sticklebacks on North Uist, Scotland, we previously investigated the role of predation pressure and calcium limitation on the adaptive evolution of stickleback morphology and behavior. While dissolved calcium proved a significant predictor of plate and spine morph, predator abundance did not. Ecol. Evol., xxx, 2014 and xxx performed a comparable analysis to our own to address the same question. They failed to detect a significant effect of dissolved calcium on morphological evolution, but did establish a significant effect of predation; albeit in the opposite direction to their prediction. PMID:25478147

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lieber, E.; Grady, V.; Dosik, H.

A 4 lb 8 oz female was born to a 49-year-old woman (P1200G12) at 40 weeks. The baby had tetralogy of Fallot, polydactyly, microcephaly, low set simple ears, posterior cleft of the soft palate and overlapping flexion deformities of both hands. The eyes were deep set. The clinical impression was trisomy 13. The baby is not doing well and needs a gastrotomy tube for feeding. Sucking is allright but swallowing is impeded. An MRI showed an anomaly of the corpus callosum. The ophthalmological examination showed no abnormalities. A chromosome study on a 2-day peripheral blood sample resulted in poor growthmore » and poor morphology; however, 20 Giemsa-banded cells revealed a 47,XXX karyotype. A second specimen was obtained to search for mosaicism and a blood smear revealed nuclear projections on the neutrophils. FISH analysis using whole chromosome painting probe (Life Technologies) first identified the extra chromosome number 13, the final results showing five of sixty metaphase cells (8.3%) with trisomy 13. Cytogenetic analysis using Giemsa-banding technique revealed four cells in fifty examined (8.0%) with a 48,XXX,+13 karyotype. In order to further evaluate the mosaicism, cytogenetic analysis of a skin fibroblast culture was performed. Twenty one of twenty three cells examined (91.3%) showed the 48,XXX,+13 karyotype. FISH analysis of the skin biopsy revealed eighteen of twenty cells (90.9%) with the trisomy 13. The FISH technique is an important enhancement to routine cytogenetic studies when they do not immediately correlate with clinical impressions.« less

Assessment of fetal sex chromosome aneuploidy using directed cell-free DNA analysis.

PubMed

Nicolaides, Kypros H; Musci, Thomas J; Struble, Craig A; Syngelaki, Argyro; Gil, M M

2014-01-01

To examine the performance of chromosome-selective sequencing of cell-free (cf) DNA in maternal blood for assessment of fetal sex chromosome aneuploidies. This was a case-control study of 177 stored maternal plasma samples, obtained before fetal karyotyping at 11-13 weeks of gestation, from 59 singleton pregnancies with fetal sex chromosome aneuploidies (45,X, n = 49; 47,XXX, n = 6; 47,XXY, n = 1; 47,XYY, n = 3) and 118 with euploid fetuses (46,XY, n = 59; 46,XX, n = 59). Digital analysis of selected regions (DANSR™) on chromosomes 21, 18, 13, X and Y was performed and the fetal-fraction optimized risk of trisomy evaluation (FORTE™) algorithm was used to estimate the risk for non-disomic genotypes. Performance was calculated at a risk cut-off of 1:100. Analysis of cfDNA provided risk scores for 172 (97.2%) samples; 4 samples (45,X, n = 2; 46,XY, n = 1; 46,XX, n = 1) had an insufficient fetal cfDNA fraction for reliable testing and 1 case (47,XXX) failed laboratory quality control metrics. The classification was correct in 43 (91.5%) of 47 cases of 45,X, all 5 of 47,XXX, 1 of 47,XXY and 3 of 47,XYY. There were no false-positive results for monosomy X. Analysis of cfDNA by chromosome-selective sequencing can correctly classify fetal sex chromosome aneuploidy with reasonably high sensitivity. © 2013 S. Karger AG, Basel.

78 FR 75554 - Combined Notice of Filings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-12

.... ET 12/16/13. Docket Numbers: RP14-247-000. Applicants: Sea Robin Pipeline Company, LLC. Description: Sea Robin Pipeline Company, LLC submits tariff filing per 154.312: Sea Robin Docket No. RP14-xxx Rate...

Aspects of Self and Identity in Narrations About Recent Events: Communication With Individuals With Alzheimer's Disease Enabled by a Digital Photograph Diary.

PubMed

Karlsson, Eva; Zingmark, Karin; Axelsson, Karin; Sävenstedt, Stefan

2017-02-02

HOW TO OBTAIN CONTACT HOURS BY READING THIS ARTICLE INSTRUCTIONS XX contact hours will be awarded by Villanova University College of Nursing upon successful completion of this activity. A contact hour is a unit of measurement that denotes 60 minutes of an organized learning activity. This is a learner-based activity. Villanova University College of Nursing does not require submission of your answers to the quiz. A contact hour certificate will be awarded once you register, pay the registration fee, and complete the evaluation form online at http://goo.gl/gMfXaf. To obtain contact hours you must: 1. Read the article, "XXXX XXXX XXXXXX XXXXXXX XXXX XXXX XXX XXX XXXX XX" found on pages XX-XX, carefully noting any tables and other illustrative materials that are included to enhance your knowledge and understanding of the content. Be sure to keep track of the amount of time (number of minutes) you spend reading the article and completing the quiz. 2. Read and answer each question on the quiz. After completing all of the questions, compare your answers to those provided within this issue. If you have incorrect answers, return to the article for further study. 3. Go to the Villanova website listed above to register for contact hour credit. You will be asked to provide your name; contact information; and a VISA, MasterCard, or Discover card number for payment of the $20.00 fee. Once you complete the online evaluation, a certificate will be automatically generated. This activity is valid for continuing education credit until MONTH XX, 20XX. CONTACT HOURS This activity is co-provided by Villanova University College of Nursing and SLACK Incorporated. Villanova University College of Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation. ACTIVITY OBJECTIVES 1. XXX 2. XXX DISCLOSURE STATEMENT Neither the planners nor the author have any conflicts of interest to disclose. The ability to narrate autobiographical memories is important for maintaining the identity of individuals with Alzheimer's disease (AD). The current study explored how the sense of self is manifested in narrations about recent events, enabled via a digital photograph diary. Use of a digital photograph diary was tested with seven individuals with AD and their household members. Narrative analysis was used to analyze audiorecordings of the pairs' communication about recent events shown in the photographs. The results show how individuals with AD understand events illustrated in recent photographs in relation to their sense of self and associated skills and abilities that are facets of their selfhood. This type of digital photograph diary has the potential to support individuals with AD to maintain their sense of self and participation in everyday life, and strengthen their relationships with household members; it could be an important tool in person-centered care. [Journal of Gerontological Nursing, xx(x), xx-xx.]. Copyright 2017, SLACK Incorporated.

2. Historic American Buildings Survey 'Stable and Smoke House' Photocopy ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey 'Stable and Smoke House' Photocopy of Plate XXX From: Brown, Glenn, The Octagon, Washington, N.D. - Octagon House, Stable, 1799 New York Avenue Northwest, Washington, District of Columbia, DC

Bierman {ital et al.}Reply:

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bierman, J.D.; Chan, P.; Liang, J.F.

1997-05-01

reply to the Comment by C.H.Dasso et al., Phys. Rev. Lett. 78,XXX(1997). A Reply to the Comment by C.H. Dasso and J. Fern{acute a}ndez-Niello. {copyright} {ital 1997} {ital The American Physical Society}

The craniofacial complex in 47, XXX females.

PubMed

Krusinskiene, Viktorija; Krusinskie, Viktorija; Alvesalo, Lassi; Sidlauskas, Antanas

2005-08-01

A study of the craniofacial complex in four 47, XXX Finnish females, or females with an extra X chromosome, was carried out using cephalometric analysis comprising linear and angular measurements. The lengths of the anterior and posterior cranial bases, the calvarium, mandibular ramus and posterior and upper anterior face heights were found to be significantly shorter than in female controls, while the angles between the foraminal and clival planes, the mandibular plane and cranial base, the maxillary and occlusal planes, the maxillary and mandibular planes and the foraminal and mandibular planes, and also the gonial angle, were significantly enlarged. The present findings of reduced linear measurements, together with the results of studies on the craniofacial complex of 47, XXY and 47, XYY males, suggest dimensional variation between these groups from the promoting effect of an extra Y chromosome and the retarding effect of an extra X chromosome on craniofacial growth.

Development and characterization of Powder Metallurgy (PM) 2XXX series Al alloy products and Metal Matrix Composite (MMC) 2XXX Al/SiC materials for high temperature aircraft structural applications

NASA Technical Reports Server (NTRS)

Chellman, D. J.; Gurganus, T. B.; Walker, J. A.

1992-01-01

The results of a series of material studies performed by the Lockheed Aeronautical Systems Company over the time period from 1980 to 1991 are discussed. The technical objective of these evaluations was to develop and characterize advanced aluminum alloy materials with temperature capabilities extending to 350 F. An overview is given of the first five alloy development efforts under this contract. Prior work conducted during the first five modifications of the alloy development program are listed. Recent developments based on the addition of high Zr levels to an optimum Al-Cu-Mg alloy composition by powder metallurgy processing are discussed. Both reinforced and SiC or B4C ceramic reinforced alloys were explored to achieve specific target goals for high temperature aluminum alloy applications.

Dynamical pairwise entanglement and two-point correlations in the three-ligand spin-star structure

NASA Astrophysics Data System (ADS)

Motamedifar, M.

2017-10-01

We consider the three-ligand spin-star structure through homogeneous Heisenberg interactions (XXX-3LSSS) in the framework of dynamical pairwise entanglement. It is shown that the time evolution of the central qubit ;one-particle; state (COPS) brings about the generation of quantum W states at periodical time instants. On the contrary, W states cannot be generated from the time evolution of a ligand ;one-particle; state (LOPS). We also investigate the dynamical behavior of two-point quantum correlations as well as the expectation values of the different spin-components for each element in the XXX-3LSSS. It is found that when a W state is generated, the same value of the concurrence between any two arbitrary qubits arises from the xx and yy two-point quantum correlations. On the opposite, zz quantum correlation between any two qubits vanishes at these time instants.

Investigation of the formability of aluminium alloys at elevated temperatures

NASA Astrophysics Data System (ADS)

Tisza, M.; Budai, D.; Kovács, P. Z.; Lukács, Zs

2016-11-01

Aluminium alloys are more and more widely applied in car body manufacturing. Increasing the formability of aluminium alloys are one of the most relevant tasks in todays’ research topics. In this paper, the focus will be on the investigation of the formability of aluminium alloys concerning those material grades that are more widely applied in the automotive industry including the 5xxx and 6xxx aluminium alloy series. Recently, besides the cold forming of aluminium sheets the forming of aluminium alloys at elevated temperatures became a hot research topic, too. In our experimental investigations, we mostly examined the EN AW 5754 and EN AW 6082 aluminium alloys at elevated temperatures. We analysed the effect of various material and process parameters (e.g. temperature, sheet thickness) on the formability of aluminium alloys with particular emphasis on the Forming Limit Diagrams at elevated temperatures in order to find the optimum forming conditions for these alloys.

Study of the invariant structure function of the reaction. pi. /sup -/p. --> gamma. /sup +/xxx at 5 GeV/c

DOE Office of Scientific and Technical Information (OSTI.GOV)

Amaglobeli, N.S.; Budagov, Y.A.; Valkar, S.

1977-07-01

The invariant differential cross section f (x,p/sub perpendicular/) of the reaction ..pi../sup -/p..--> gamma../sup +/xxx at 5 GeV/c was measured in a broad range of x and p/sub perpendicular/. An approximating formula is found for f (x,p/sub perpendicular/). It is shown that the function f (x,p/sub perpendicular/) is not factorizable in the variables x and p/sub perpendicular/. In some regions of phase space scale-invariant (scaling) behavior of the differential cross section is observed. Analysis of the asymmetry of the longitudinal momentum spectrum of the photons indicates that the production mechanisms of neutral and charged pions are similar in the centralmore » region. The results of the analysis are in qualitative agreement with the predictions of the quark model of hadrons.« less

Conformational diversity in contryphans from Conus venom: cis-trans isomerisation and aromatic/proline interactions in the 23-membered ring of a 7-residue peptide disulfide loop.

PubMed

Sonti, Rajesh; Gowd, Konkallu Hanumae; Rao, K N Shashanka; Ragothama, Srinivasarao; Rodriguez, Alex; Perez, Juan Jesus; Balaram, Padmanabhan

2013-11-04

Conformational diversity or "shapeshifting" in cyclic peptide natural products can, in principle, confer a single molecular entity with the property of binding to multiple receptors. Conformational equilibria have been probed in the contryphans, which are peptides derived from Conus venom possessing a 23-membered cyclic disulfide moiety. The natural sequences derived from Conus inscriptus, GCV(D)LYPWC* (In936) and Conus loroisii, GCP(D)WDPWC* (Lo959) differ in the number of proline residues within the macrocyclic ring. Structural characterisation of distinct conformational states arising from cis-trans equilibria about Xxx-Pro bonds is reported. Isomerisation about the C2-P3 bond is observed in the case of Lo959 and about the Y5-P6 bond in In936. Evidence is presented for as many as four distinct species in the case of the synthetic analogue V3P In936. The Tyr-Pro-Trp segment in In936 is characterised by distinct sidechain orientations as a consequence of aromatic/proline interactions as evidenced by specific sidechain-sidechain nuclear Overhauser effects and ring current shifted proton chemical shifts. Molecular dynamics simulations suggest that Tyr5 and Trp7 sidechain conformations are correlated and depend on the geometry of the Xxx-Pro bond. Thermodynamic parameters are derived for the cis↔trans equilibrium for In936. Studies on synthetic analogues provide insights into the role of sequence effects in modulating isomerisation about Xxx-Pro bonds. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Pressure dependence of side chain 13C chemical shifts in model peptides Ac-Gly-Gly-Xxx-Ala-NH2.

PubMed

Beck Erlach, Markus; Koehler, Joerg; Crusca, Edson; Munte, Claudia E; Kainosho, Masatsune; Kremer, Werner; Kalbitzer, Hans Robert

2017-10-01

For evaluating the pressure responses of folded as well as intrinsically unfolded proteins detectable by NMR spectroscopy the availability of data from well-defined model systems is indispensable. In this work we report the pressure dependence of 13 C chemical shifts of the side chain atoms in the protected tetrapeptides Ac-Gly-Gly-Xxx-Ala-NH 2 (Xxx, one of the 20 canonical amino acids). Contrary to expectation the chemical shifts of a number of nuclei have a nonlinear dependence on pressure in the range from 0.1 to 200 MPa. The size of the polynomial pressure coefficients B 1 and B 2 is dependent on the type of atom and amino acid studied. For H N , N and C α the first order pressure coefficient B 1 is also correlated to the chemical shift at atmospheric pressure. The first and second order pressure coefficients of a given type of carbon atom show significant linear correlations suggesting that the NMR observable pressure effects in the different amino acids have at least partly the same physical cause. In line with this observation the magnitude of the second order coefficients of nuclei being direct neighbors in the chemical structure also are weakly correlated. The downfield shifts of the methyl resonances suggest that gauche conformers of the side chains are not preferred with pressure. The valine and leucine methyl groups in the model peptides were assigned using stereospecifically 13 C enriched amino acids with the pro-R carbons downfield shifted relative to the pro-S carbons.

Changing patterns of daily rhythmicity across reproductive states in diurnal female Nile grass rats (Arvicanthis niloticus)

PubMed Central

Schradera, Jessica A.; Walaszczykb, Erin J.; Smalea, Laura

2009-01-01

SCHRADER, J.A., E. J. WALASZCZYK, AND L. SMALE. Changing patterns of daily rhythmicity across reproductive states in diurnal female Nile grass rats (Arvicanthis niloticus). PHYSIOL BEHAV XX(X) XXX-XXX, XXXX. -- A suite of changes in circadian rhythms have been described in nocturnal rodents as females go through pregnancy and lactation, but there is no information on such patterns in diurnal species. As the challenges faced by these two groups of animals are somewhat different, we characterized changes in activity and core body temperature (Tb) in female diurnal Nile grass rats (Arvicanthis niloticus) as they went through a series of reproductive states: virgin, pregnant, pregnant and lactating, lactating only, and post-weaning. The phase of neither rhythm varied, but the amplitude did. Females increased their overall levels of daily activity from early to late pregnancy, regardless of whether they were also lactating. The pattern of activity was less rhythmic during early than mid-lactation, in both non-pregnant and pregnant females, as a consequence of a decrease in daytime relative to nighttime activity. The Tb rhythm amplitude dropped from mid-pregnancy through mid-lactation, and there were rises in Tb troughs during the mid-light and mid-dark phases of the day, though pregnancy and lactation affected Tb at these times in somewhat different ways. This study demonstrates that rhythms in diurnal grass rats change during pregnancy and lactation in different ways than those of nocturnal species that have been studied to date and that the effects of pregnancy and lactation are not additive in any simple way. PMID:19744504

Concurrent insulinoma with mosaic Turner syndrome: A case report.

PubMed

Wang, Shaoyun; Yang, Lijuan; Li, Jie; Mu, Yiming

2015-03-01

Turner syndrome is a chromosomal abnormality in which the majority of patients have a 45XO karyotype, while a small number have a 45XO/47XXX karyotype. Congenital adrenal hyperplasia has been previously reported in patients with Turner syndrome. Although insulinomas are the most common type of functioning pancreatic neuroendocrine tumor and have been reported in patients with multiple endocrine neoplasias, the tumors have not been reported in patients with mosaic Turner syndrome. The present study reports the first case of an insulinoma in a patient with 45XO/47XXX mosaic Turner syndrome. The patient suffered from recurrent hypoglycemia, which was relieved following ingestion of glucose or food. A 5-h glucose tolerance test was performed and the levels of glucose, C-Peptide and insulin were detected. In addition, computed tomography (CT) and ultrasound scanning were performed to evaluate the possibility of an insulinoma. Pathological examination and karyotyping were performed on a surgical specimen and a whole blood sample, respectively. The patient was found to suffer from premature ovarian failure, and a physical examination was consistent with a diagnosis of Turner syndrome. An ultrasound scan demonstrated streak ovaries and the patient was found to have a 45XO/47XXX karyotype. Furthermore, a lesion was detected in the pancreas following CT scanning, which was identified as an insulinoma following surgical removal and histological examination. In conclusion, the present study reports the first case of an insulinoma in a patient with mosaic Turner syndrome. Since mosaic Turner syndrome and insulinoma are rare diseases, an association may exist that has not been previously identified.

Identity Activities

DTIC Science & Technology

2016-08-03

individual or organization knows or says about another individual         Core personal Addresses Employment Educational Military Service...rhythm; handwriting ; type/keyboard pattern; posture/bearing; gait/limp; gestures). Appendix D D-8 JDN X-XX (3) Financial Transactions. Any

32 CFR 158.7 - Guidance for contractor medical and dental fitness.

Code of Federal Regulations, 2014 CFR

2014-07-01

... “shot record,” available for purchase at http://bookstore.gpo.gov/collections/vaccination.jsp). (g... employee with one of the conditions listed in paragraphs (j)(2)(i) through (j)(2)(xxx) of this section can...

32 CFR 158.7 - Guidance for contractor medical and dental fitness.

Code of Federal Regulations, 2013 CFR

2013-07-01

... “shot record,” available for purchase at http://bookstore.gpo.gov/collections/vaccination.jsp). (g... employee with one of the conditions listed in paragraphs (j)(2)(i) through (j)(2)(xxx) of this section can...

32 CFR 158.7 - Guidance for contractor medical and dental fitness.

Code of Federal Regulations, 2012 CFR

2012-07-01

... “shot record,” available for purchase at http://bookstore.gpo.gov/collections/vaccination.jsp). (g... employee with one of the conditions listed in paragraphs (j)(2)(i) through (j)(2)(xxx) of this section can...

Characterization of beta phase growth and experimental validation of long term thermal exposure sensitization of AA5XXX alloys

NASA Astrophysics Data System (ADS)

Zhu, Yakun

The United States Navy has a need for fast, light-weight ships to provide rapid deployment in its operations. Strong and corrosion-resistant aluminum alloys, such as AA5083 (UNS A95083) as well as other AA5XXX alloys, have properties that are well-suited for such applications. However, AA5XXX alloys are susceptible to intergranular corrosion (IGC) and stress corrosion cracking (SCC) because of sensitization which is a consequence of the formation of the grain boundary beta-phase, Al3Mg2, and the anodic dissolution of the beta-phase. Significant research has been performed to measure and understand the effects of time, temperature, stress, and sea water on sensitization and associated intergranular corrosion and stress corrosion cracking under steady-state conditions. In the present work, the behaviors of beta-phase nucleation and growth were characterized using optical and electron microscopy, the relationship between preexisting particles and beta-phase, as well as the effect of different heat treatment times and temperatures on IGC and SCC susceptibility of 5XXX alloys were investigated. Grain boundary beta-phase thickness was measured with high resolution transmission electron microscopy (TEM). The corrosion sensitization susceptibility was evaluated according to the American Society for Testing and Materials (ASTM) standard G67 tests, that is, nitric acid mass-loss testing (NAMLT). Diffusion of Mg is manifested by the thickening of beta-phase along the grainboundary because the grain boundary is considered as the preferential site for beta-phase nucleation. The beta-phase growth rate was monitored using high resolution TEM. The variety of precipitates and their subsequent effects on beta-phase nucleation and growth kinetics was investigated. The existence of various intermetallic particles was observed in both baseline and thermally exposed (70°C and 175°C) samples. These particles are usually either rod-shaped or equiaxed, and rich in Mn, Fe, and Cr. Indexing of lattice planes observed in a few of these particles suggested the composition is Al6Mn or Al6(Mn, Fe, Cr). This research also shows that the beta-phase precipitation occurs between the preexisting Mn rich particles. The basic model for the determination of diffusivity values, the prediction of beta-phase thickness growth, and corrosion sensitization prediction have been improved by new data from this research.

Management of sacroiliac joint disruption and degenerative sacroiliitis with nonoperative care is medical resource-intensive and costly in a United States commercial payer population

PubMed Central

Ackerman, Stacey J; Polly, David W; Knight, Tyler; Holt, Tim; Cummings, John

2014-01-01

Introduction Low back pain is common and originates in the sacroiliac (SI) joint in 15%–30% of cases. Traditional SI joint disruption/degenerative sacroiliitis treatments include nonoperative care or open SI joint fusion. To evaluate the usefulness of newly developed minimally-invasive technologies, the costs of traditional treatments must be better understood. We assessed the costs of nonoperative care for SI joint disruption to commercial payers in the United States (US). Methods A retrospective study of claim-level medical resource use and associated costs used the MarketScan® Commercial Claims and Encounters as well as Medicare Supplemental Databases of Truven Healthcare. Patients with a primary ICD-9-CM diagnosis code for SI joint disruption (720.2, 724.6, 739.4, 846.9, or 847.3), an initial date of diagnosis from January 1, 2005 to December 31, 2007 (index date), and continuous enrollment for ≥1 year before and 3 years after the index date were included. Claims attributable to SI joint disruption with a primary or secondary ICD-9-CM diagnosis code of 71x.xx, 72x.xx, 73x.xx, or 84x.xx were identified; the 3-year medical resource use-associated reimbursement and outpatient pain medication costs (measured in 2011 US dollars) were tabulated across practice settings. A subgroup analysis was performed among patients with lumbar spinal fusion. Results The mean 3-year direct, attributable medical costs were $16,196 (standard deviation [SD] $28,592) per privately-insured patient (N=78,533). Among patients with lumbar spinal fusion (N=434), attributable 3-year mean costs were $91,720 (SD $75,502) per patient compared to $15,776 (SD $27,542) per patient among patients without lumbar spinal fusion (N=78,099). Overall, inpatient hospitalizations (19.4%), hospital outpatient visits and procedures (14.0%), and outpatient pain medications (9.6%) accounted for the largest proportion of costs. The estimated 3-year insurance payments attributable to SI joint disruption were $1.6 billion per 100,000 commercial payer beneficiaries. Conclusion The economic burden of SI joint disruption among privately-insured patients in the US is substantial, highlighting the need for more cost-effective therapies. PMID:24596468

Neumann boundary controllability of the Gear-Grimshaw system with critical size restrictions on the spatial domain

NASA Astrophysics Data System (ADS)

Capistrano-Filho, Roberto A.; Gallego, Fernando A.; Pazoto, Ademir F.

2016-10-01

In this paper, we study the boundary controllability of the Gear-Grimshaw system posed on a finite domain (0, L), with Neumann boundary conditions: ut + uu_x+u_{xxx} + a v_{xxx} + a_1vv_x+a_2 (uv)_x =0, & {in} (0,L)× (0,T), c v_t +rv_x +vv_x+abu_{xxx} +v_{xxx}+a_2buu_x+a_1b(uv)_x =0, &{in} (0,L)× (0,T), u_{xx}(0,t)=h_0(t), u_x(L,t)=h_1(t), u_{xx}(L,t)=h_2(t), &{in} (0,T), v_{xx}(0,t)=g_0(t), v_x(L,t)=g_1(t), v_{xx}(L,t)=g_2(t), &{in} (0,T), u(x,0)= u^0(x), quad v(x,0)= v^0(x), & {in} (0,L). We first prove that the corresponding linearized system around the origin is exactly controllable in {(L^2(0,L))^2} when h 2( t) = g 2( t) = 0. In this case, the exact controllability property is derived for any L > 0 with control functions {h_0, g_0 in H^{-1/3}(0,T)} and {h_1, g_1in L^2(0,T)}. If we change the position of the controls and consider {h_0(t)=h_2(t)=0} (resp. {g_0(t)=g_2(t)=0)}, we obtain the result with control functions {g_0, g_2in H^{-1/3}(0,T)} and {h_1, g_1in L^2(0,T)} if and only if the length L of the spatial domain (0, L) does not belong to a countable set. In all cases, the regularity of the controls are sharp in time. If only one control act in the boundary condition, {h_0(t)=g_0(t)=h_2(t)=g_2(t)=0} and g 1( t) = 0 (resp. h 1( t) = 0), the linearized system is proved to be exactly controllable for small values of the length L and large time of control T. Finally, the nonlinear system is shown to be locally exactly controllable via the contraction mapping principle, if the associated linearized systems are exactly controllable.

GEWEX Radiative Flux Assessment Available Data

Atmospheric Science Data Center

2016-05-31

... ERBE--ERBS-NOAA10_EdXXX ERBE/ERBS + NOAA 10 Scanner 2.5 degree monthly mean data from 02/87 to 05/89 ... GEWEX Radiative Flux Assessment data were obtained from the NASA Langley Research Center Atmospheric Science Data Center. " In addition, ...

76 FR 14807 - Delegation of National Emission Standards for Hazardous Air Pollutants for Source Categories...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-18

... Reforming, and Sulfur Recovery Units. VVV Publicly Owned Treatment X X X Works. XXX Ferroalloys Production.... LLLLL Asphalt Roofing and X X X Processing. MMMMM Flexible Polyurethane X X X Foam Fabrication Operation...

Special Specification 3XXX, dense-graded hot-mix asphalt.

DOT National Transportation Integrated Search

2004-01-01

Construct a hot-mix asphalt (HMA) pavement layer composed of a compacted, dense-graded mixture of aggregate and asphalt binder mixed hot in a mixing plant. Pay adjustments will apply to HMA placed under this specification unless the HMA is deemed exe...

The Japanese Keigo Verbal Marker

ERIC Educational Resources Information Center

Rahayu, Ely Triasih

2013-01-01

This research studies Japanese "keigo" in the office domain, a case study at XXX Corporation Japan. "Keigo" consists of "sonkeigo," "kenjougo," and "teineigo." Each of those speech levels is going to be analyzed based on linguistic and nonlinguistic factors. In this qualitative research, the data…

Factors influencing parental decision making in prenatal diagnosis of sex chromosome aneuploidy.

PubMed

Mezei, Gábor; Papp, Csaba; Tóth-Pál, Ernö; Beke, Artúr; Papp, Zoltán

2004-07-01

To evaluate factors influencing parental decisions toward continuing or terminating a pregnancy with prenatal diagnosis of sex chromosome aneuploidy. We reviewed the records of patients with fetuses with sex chromosome aneuploidy between 1990 and 2001. A questionnaire survey of women who chose to terminate such pregnancies was designed to examine aspects of their decision-making process. Forty-nine of 89 pregnancies with sex chromosome aneuploidy were terminated (termination rate 0.55; 95% confidence interval 0.45-0.65). Pregnancies with abnormal ultrasound findings (14/16, 87%), with 45,X or 47,XXY karyotypes (26/36, 72%), and with nonmosaic karyotypes (30/48, 63%) were terminated significantly more often than pregnancies with normal ultrasound findings (35/73, 48%; P <.01), with 47,XXX or 47,XYY karyotypes (4/12, 33%; P <.05), and with mosaic karyotypes (5/25, 20%; P =.01). There was a trend (P =.136) toward a lower rate of termination from 67% to 36% across time, with a significant decrease from 67% to 7% in pregnancies with 47,XXX; 47,XYY; and mosaic karyotypes (P <.01), and no change in cases with 45,X and 47,XXY karyotypes (67% compared with 69%; P = 1.0). Abnormal sexual development and infertility were the greatest parental concerns related to termination. Fear of having a child with abnormal sexual development or infertility remains the major determinant of parental decision toward terminating pregnancy, resulting in consistently high termination rates across time in pregnancies with 45,X and 47,XXY karyotypes. In cases with 47,XXX; 47,XYY; and mosaic karyotypes, the declining termination rate across time is a consequence of recent studies reporting normal sexual development and fertility.

Expanding the phenotype of Triple X syndrome: A comparison of prenatal versus postnatal diagnosis.

PubMed

Wigby, Kristen; D'Epagnier, Cheryl; Howell, Susan; Reicks, Amy; Wilson, Rebecca; Cordeiro, Lisa; Tartaglia, Nicole

2016-11-01

Triple X syndrome (47, XXX) occurs in approximately 1:1,000 female births and has a variable phenotype of physical and psychological features. Prenatal diagnosis rates of 47, XXX are increasing due to non-invasive prenatal genetic testing. Previous studies suggest that prenatal diagnosed females have better neurodevelopmental outcomes. This cross-sectional study describes diagnosis, physical features, medical problems, and neurodevelopmental features in a large cohort of females with 47, XXX. Evaluation included review of medical and developmental history, physical exam, cognitive, and adaptive testing. Medical and developmental features were compared between the prenatal and postnatal diagnosis groups using rate calculations and Fisher's exact test. Cognitive and adaptive tests scores were compared using t-tests. Seventy-four females age 6 months-24 years (mean 8.3 years) participated. Forty-four (59.5%) females were in the prenatal diagnosis group. Mean age of postnatal diagnosis was 5.9 years; developmental delay was the most common indication for postnatal genetic testing. Common physical features included hypertelorism, epicanthal folds, clinodactyly, and hypotonia. Medical problems included dental disorders (44.4%), seizure disorders (16.2%), genitourinary malformations (12.2%). The prenatal diagnosis group had higher verbal (P < 0.001), general ability index (P = 0.004), and adaptive functioning scores (P < 0.001). Rates of ADHD (52.2% vs. 45.5%, P = 0.77) and learning disabilities (39.1% vs. 36.3%, P = 1.00) were similar between the two groups. These findings expand on the phenotypic features in females with Triple X syndrome and support that prenatally ascertained females have better cognitive and functional outcomes. However, prenatally diagnosed females are still at risk for neurodevelopmental disorders. Genetic counseling and treatment recommendations are summarized. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Expression pattern of X-linked genes in sex chromosome aneuploid bovine cells.

PubMed

Basrur, Parvathi K; Farazmand, Ali; Stranzinger, Gerald; Graphodatskaya, Daria; Reyes, Ed R; King, W Allan

2004-01-01

Expression of the X-inactive specific transcript (XIST) gene is a prerequisite step for dosage compensation in mammals, accomplished by silencing one of the two X chromosomes in normal female diploid cells or all X chromosomes in excess of one in sex chromosome aneuploids. Our previous studies showing that XIST expression does not eventuate the inactivation of X-linked genes in fetal bovine testis had suggested that XIST expression may not be an indicator of X inactivation in this species. In this study, we used a semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) approach on cultures of bovine cells with varying sex chromosome constitution (XY, XX, XXY and XXX) to test whether the levels of XIST expressed conform to the number of late replicating (inactive) X chromosomes displayed by proliferating cells in these cultures. Expression patterns of four X-linked genes, including hypoxanthine phosphorybosyl transferase (HPRT), glucose-6-phosphate dehydrogenase (G6PD), zinc finger protein locus on the X (ZFX). and 'selected mouse cDNA on the X' (SMCX), in all these cells were also tested. Results showed that XIST expression was significantly higher (p < 0.05) in XXX cells compared to XX and XXY cells and that G6PD. HPRT, and SMCX loci are subject to X inactivation. The significantly higher levels of ZFX expressed in XXX cells compared to XX and XXY cells (p < 0.05) confirmed that this bovine locus, as human ZFX, escapes X inactivation. However, the levels of XIST and ZFX expressed were not proportional to the X chromosome load in these cells suggesting that X-linked loci escaping inactivation may be regulated at transcription (or post-transcription) level by mechanisms that prevent gene-specific product accumulation beyond certain levels in sex chromosome aneuploids.

Absence of high-temperature ballistic transport in the spin-1/2 XXX chain within the grand-canonical ensemble

NASA Astrophysics Data System (ADS)

Carmelo, J. M. P.; Prosen, T.

2017-01-01

Whether in the thermodynamic limit, vanishing magnetic field h → 0, and nonzero temperature the spin stiffness of the spin-1/2 XXX Heisenberg chain is finite or vanishes within the grand-canonical ensemble remains an unsolved and controversial issue, as different approaches yield contradictory results. Here we provide an upper bound on the stiffness and show that within that ensemble it vanishes for h → 0 in the thermodynamic limit of chain length L → ∞, at high temperatures T → ∞. Our approach uses a representation in terms of the L physical spins 1/2. For all configurations that generate the exact spin-S energy and momentum eigenstates such a configuration involves a number 2S of unpaired spins 1/2 in multiplet configurations and L - 2 S spins 1/2 that are paired within Msp = L / 2 - S spin-singlet pairs. The Bethe-ansatz strings of length n = 1 and n > 1 describe a single unbound spin-singlet pair and a configuration within which n pairs are bound, respectively. In the case of n > 1 pairs this holds both for ideal and deformed strings associated with n complex rapidities with the same real part. The use of such a spin 1/2 representation provides useful physical information on the problem under investigation in contrast to often less controllable numerical studies. Our results provide strong evidence for the absence of ballistic transport in the spin-1/2 XXX Heisenberg chain in the thermodynamic limit, for high temperatures T → ∞, vanishing magnetic field h → 0 and within the grand-canonical ensemble.

Age, experience and genetic background influence treadmill walking in mice

PubMed Central

Wooley, Christine M.; Xing, Shuqin; Burgess, Robert W.; Cox, Gregory A.; Seburn, Kevin L.

2009-01-01

WOOLEY, C.M., S. XING, R.W. BURGESS, G.A. COX, AND K.L. SEBURN. Age, experience and genetic background influence treadmill walking in mice. PHYSIOL. BEHAV. XX(X), XXX-XXX, 2008 – The use of a treadmill to gather data for gait analysis in mice is a convenient, sensitive method to evaluate motor performance. However, evidence from several species, including mice, shows that treadmill locomotion is a novel task that is not equivalent to over ground locomotion and that may be particularly sensitive to the test environment and protocol. We investigated the effects of age, genetic background and repeated trials on treadmill walking in mice and show that these factors are important considerations in the interpretation of gait data. Specifically we report that as C57BL/6J (B6) mice age, the animals use progressively longer, less frequent strides to maintain the same walking speed. The increase is most rapid between 1 and 6 months of age and is explained, in part, by changes in size and weight. We also extended previous findings showing that repeat trials cause mice to modify their treadmill gait pattern. In general, B6 mice tend to take shorter, more frequent steps and adopt a wider dynamic stance with repeated walking trials. The nature and extent of the response changes with both the number and timing of the trials and was observed with inter-trial intervals as long as 3 months. Finally, we compared the gait pattern of an additional seven inbred strains of mice and found significant variation in the length and frequency of strides used to maintain the same walking speed. The combined results offer the bases for further mechanistic studies and can be used to guide optimal experimental design. PMID:19027767

THE CELLULAR METABOLISM AND SYSTEMIC TOXICITY OF ARSENIC

EPA Science Inventory

Abstract

Toxic Consequences of the Metabolism of Arsenic. David J. Thomas, Miroslav Styblo, and Shan Lin. (2001). Toxicol. Appl. Pharmacol. 000, xxx-yyy.
Although it has been known for decades that humans and many other species metabolize inorganic arsenic to methyl ...

75 FR 8496 - Approval and Promulgation of Implementation Plans; Ohio New Source Review Rules

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-25

... CFR 51.166 and 51.165 definitions in OAC 3745-31-01 (E), (J), (M), (X), (JJ), (QQ), (DDD), (EEE), (XXX...), (N), (O), (P), (Q), (S), (T), (U), (V), (W), (X), (DD), (EE), (FF), (GG), (JJ), (MM), (NN), (QQ...

Polycrystal-Plasticity Simulation of Roping in AA 6xxx Automotive Sheet Alloys

NASA Astrophysics Data System (ADS)

Engler, O.; Schäfer, C.; Brinkman, H.-J.

The occurrence of roping in AA 6xxx series sheet for car body applications is caused by the collective deformation of band-like clusters of grains with similar crystallographic orientation. In this study large-scale orientation maps obtained by electron back-scattered diffraction (EBSD) are input into a visco-plastic self-consistent polycrystal-plasticity model to analyze the strain anisotropy caused by the topographic arrangement of the recrystallization texture orientations and, in turn, the occurrence of roping. At variance to earlier studies, the measurements were carried out in the short transverse section of the sheets so as to get information on distribution and morphology of orientation clusters through the sheet thickness. Then, narrow bands in the EBSD maps aligned parallel to the ridges on the sheet surface are considered, and the variation in macroscopic strain response from band to band is determined. For a given deformation of the sample these simulations yield quantitative information on the level of roping of Al-alloy sheet for car body applications.

Development and Processing Improvement of Aerospace Aluminum Alloys-Development of AL-Cu-Mg-Ag Alloy (2139)

NASA Technical Reports Server (NTRS)

Cho, Alex; Lisagor, W. Barry; Bales, Thomas T.

2007-01-01

This final report supplement in presentation format describes a comprehensive multi-tasked contract study to continue the development of the silver bearing alloy now registered as aluminum alloy 2139 by the Aluminum Association. Two commercial scale ingots were processed into nominal plate gauges of two, four and six inches, and were extensively characterized in terms of metallurgical and crystallographic structure, and resulting mechanical properties. This report includes comparisons of the property combinations for this alloy and 2XXX and 7XXX alloys more widely used in high performance applications. Alloy 2139 shows dramatic improvement in all combinations of properties, moreover, the properties of this alloy are retained in all gauge thicknesses, contrary to typical reductions observed in thicker gauges of the other alloys in the comparison. The advancements achieved in this study are expected to result in rapid, widespread use of this alloy in a broad range of ground based, aircraft, and spacecraft applications.

Magnetic and magnetocaloric properties of Gd2In0.8X0.2 compounds (X=Al, Ga, Sn, Pb)

NASA Astrophysics Data System (ADS)

Tencé, Sophie; Chevalier, Bernard

2016-02-01

We show that it is possible to replace in Gd2In some amount of In by X=Al, Ga, Sn and Pb to obtain Gd2In1-xXx samples after melting. The magnetic and magnetocaloric properties of the Gd2In0.8X0.2 intermetallic compounds have been investigated through dc magnetization measurements. We evidence that the substitution of Al and Ga for In barely changes the Curie temperature TC but decreases the second magnetic transition temperature T‧ which corresponds to the transition from a ferromagnetic to an antiferromagnetic state. On the other hand, the substitution of Sn and Pb for In strongly increases TC and changes the nature or even suppresses the transition at lower temperature. This magnetic behavior gives rise to an interesting way to tune the Curie temperature near room temperature without diluting the Gd network and thus to modify the magnetocaloric effect in Gd2In1-xXx compounds.

Singular eigenstates in the even(odd) length Heisenberg spin chain

NASA Astrophysics Data System (ADS)

Ranjan Giri, Pulak; Deguchi, Tetsuo

2015-05-01

We study the implications of the regularization for the singular solutions on the even(odd) length spin-1/2 XXX chains in some specific down-spin sectors. In particular, the analytic expressions of the Bethe eigenstates for three down-spin sector have been obtained along with their numerical forms in some fixed length chains. For an even-length chain if the singular solutions \\{{{λ }α }\\} are invariant under the sign changes of their rapidities \\{{{λ }α }\\}=\\{-{{λ }α }\\}, then the Bethe ansatz equations are reduced to a system of (M-2)/2((M-3)/2) equations in an even (odd) down-spin sector. For an odd N length chain in the three down-spin sector, it has been analytically shown that there exist singular solutions in any finite length of the spin chain of the form N=3(2k+1) with k=1,2,3,\\cdots . It is also shown that there exist no singular solutions in the four down-spin sector for some odd-length spin-1/2 XXX chains.

Superconducting materials with electron pairs localized on lattice ions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moizhes, B.Y.; Drabkin, I.A.

1983-07-01

We propose the following classification scheme for superconductors, depending on the probable type of electron--electron interaction: A) Semiconductors containing impurities with negative Hubbard energy in which pairs exist in r-space when T>T/sub c/: Pb/sub 1-x/Tl/sub x/Te, Ba(Pb/sub 1-x/Bi/sub x/)O/sub 3/xxx. In this case the superconducting phase transition must compete with the ordering of ions having different charges: Pb/sub 1-x/In/sub x/Te. B) Metals near the metal--insulator transition with virtual two-electron levels near the Fermi level: Na/sub x/WO/sub 3/. C) Metals containing ''active'' atoms (ions) with an odd number of electrons and a small Hubbard energy. We suggest that the contribution ofmore » diamagnetic polar configurations to the total energy of the metal can increase when coherent states are formed: Nb, La/sub 3/S/sub 4/, Nb/sub 1-x/Ti/sub x/xxx.« less

78 FR 4161 - Sport Fishing and Boating Partnership Council

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-18

...-FVWF97920900000-XXX] Sport Fishing and Boating Partnership Council AGENCY: Fish and Wildlife Service, Interior... public teleconference of the Sport Fishing and Boating Partnership Council (Council). DATES... accordance with the requirements of the Federal Advisory Committee Act, 5 U.S.C. App., we announce that Sport...

77 FR 61626 - Sport Fishing and Boating Partnership Council

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-10

...-FVWF97920900000-XXX] Sport Fishing and Boating Partnership Council AGENCY: Fish and Wildlife Service, Interior... meeting of the Sport Fishing and Boating Partnership Council (Council). A Federal advisory committee, the... Sport Fishing and Boating Partnership Council will hold a meeting. Background The Council was formed in...

12. INTERIOR OF COVERED WALKWAY BEHIND SECOND FLOOR APARTMENTS FROM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. INTERIOR OF COVERED WALKWAY BEHIND SECOND FLOOR APARTMENTS FROM OPPOSITE VIEW OF CA-XXX-11. DOOR AT PHOTO LEFT OPENS INTO THE KITCHEN OF THE WEST SIDE SECOND FLOOR APARTMENT. VIEW TO EAST. - Lee Vining Creek Hydroelectric System, Triplex Cottage, Lee Vining Creek, Lee Vining, Mono County, CA

78 FR 51737 - Notice of Issuance of Final Determination Concerning Certain Hard Disk Drives and Self-Encrypting...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-21

... the HDA incorporate semiconductor, magnetic, mechanical, and manufacturing process design into an..., mechanical surface design and manufacturing process design. It takes approximately [xxx] hours to design... brand names ``Barracuda'' and ``Desktop''. HDDs are designed in the United States and assembled either...

Movie Ratings and the Content of Adult Videos: The Sex-Violence Ratio.

ERIC Educational Resources Information Center

Yang, Ni; Linz, Daniel

1990-01-01

Quantifies sexual, violent, sexually violent, and prosocial behaviors in a sample of R-rated and X-rated videocassettes. Finds the predominant behavior in both X- and XXX-rated videos is sexual. Finds the predominant behavior in R-rated videos was violence followed by prosocial behavior. (RS)

Teaching Advanced Vehicle Dynamics Using a Project Based Learning (PBL) Approach

ERIC Educational Resources Information Center

Redkar, Sangram

2012-01-01

This paper presents an interesting teaching experiment carried out at XXX University. The author offered a new course in computational/analytical vehicle dynamics to senior undergraduate students, graduate students and practicing engineers. The objective of the course was to present vehicle dynamics theory with practical applications using…

Registration of ‘AU-1101’ peanut

USDA-ARS?s Scientific Manuscript database

AU-1101’ (Reg. No. CV-xxx, PI 661498) is a large-seeded virginia-type peanut (Arachis hypogaea L. subsp. hypogaea var. hypogaea) with high yield and medium maturity, uniform pod size and shape, high grade, superior shelling characters, low oil content, normal oleic acid content, and good flavor. AU-...

The Dot.xxx Challenge to Higher Education.

ERIC Educational Resources Information Center

Graves, William H.

2000-01-01

Describes some of the dimensions of the "e-cology" of Internet-based "e-Learning" in higher education. Discusses e-Learning service and operating dimensions; higher education's challenge to balance virtual and traditional educational delivery; instructor-led and instructor-less learning; the roles of content and instructor in instructor-led…

A Course in Baluchi. Volume Two

ERIC Educational Resources Information Center

Barker, Muhammad Abd-al-Rahman; Mengal, Aqil Khan

Volume Two contains Units XXI through XXX of the Baluchi course. Unit XXI introduces the Arabic script as adapted for Baluchi. Special conventions, abbreviations, numerals, and punctuation symbols are discussed next, and several sections are devoted to the orthography of certain substantive and verbal affies. A series of reading drills which…

Generation XXX: Pornography Acceptance and Use among Emerging Adults

ERIC Educational Resources Information Center

Carroll, Jason S.; Padilla-Walker, Laura M.; Nelson, Larry J.; Olson, Chad D.; McNamara Barry, Carolyn; Madsen, Stephanie D.

2008-01-01

This study examined correlates of pornography acceptance and use within a normative (nonclinical) population of emerging adults (individuals aged 18-26). Participants included 813 university students (500 women; M age = 20 years) recruited from six college sites across the United States. Participants completed online questionnaires regarding their…

78 FR 23587 - Sport Fishing and Boating Partnership Council

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-19

...-FVWF97920900000-XXX] Sport Fishing and Boating Partnership Council AGENCY: Fish and Wildlife Service, Interior... meeting of the Sport Fishing and Boating Partnership Council (Council). A Federal advisory committee, the... the Federal Advisory Committee Act, 5 U.S.C. App., we announce that the Sport Fishing and Boating...

76 FR 3540 - Proposed Generic Communications Reporting for Decommissioning Funding Status Reports

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-20

...-2010-0366] Proposed Generic Communications Reporting for Decommissioning Funding Status Reports AGENCY... and present to the NRC in the Decommissioning Funding Status reports to ensure that the NRC staff... Regulatory Issue Summary 2010-XXX, ``10 CFR 50-75, Reporting for Decommissioning Funding Status Reports'' is...

77 FR 12105 - 56th Meeting: RTCA Special Committee 186, Automatic Dependent Surveillance-Broadcast (ADS-B)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-28

... Existing Traffic Safety Nets EUORCAE WG51 TSAA Perpective Flight-deck Interval Management (FIM)--Status... Only Agenda Items Document Approval: DO-xxx--Minimum Aviation System Performance Standards (MASPS) for... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 56th Meeting: RTCA Special Committee...

75 FR 22805 - Federal Travel Regulation; Relocation Allowances; Standard Data Dictionary for Collection of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-30

... GENERAL SERVICES ADMINISTRATION [Proposed GSA Bulletin FTR 10-XXX; Docket 2010-0009; Sequence 1] Federal Travel Regulation; Relocation Allowances; Standard Data Dictionary for Collection of Transaction... GSA is posting online a proposed FTR bulletin that contains the data dictionary that large Federal...

75 FR 44811 - Sunshine Act Meeting of the Board of Directors and Five Board Committees

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-29

... impediments to development of numerical criteria for the measurement of LSC performance Briefing on how the..., including identification of possible impediments to development of numerical criteria for the measurement of... on Resolution 2010-XXX regarding future amendments to the LSC Accounting Manual 14. Consider and act...

Powder-Metallurgy Process And Product

NASA Technical Reports Server (NTRS)

Paris, Henry G.

1988-01-01

Rapid-solidification processing yields alloys with improved properties. Study undertaken to extend favorable property combinations of I/M 2XXX alloys through recently developed technique of rapid-solidification processing using powder metallurgy(P/M). Rapid-solidification processing involves impingement of molten metal stream onto rapidly-spinning chill block or through gas medium using gas atomization technique.

Ornamental Horticulture. Course of Study Outlines. 1975 Edition. Volume XXX.

ERIC Educational Resources Information Center

Wilson, Aubry

These courses of study in ornamental horticulture for secondary and adult technical education levels are based on a 1972 Rutgers University study and are designed to accomodate occupational needs in the field of ornamental horticulture. Job titles emphasized at the secondary level are caretaker, nurserymen, flower grower, and flower salesperson;…

Proceedings: Pacific Northwest Council on Foreign Languages. Volume XXX, Part 2.

ERIC Educational Resources Information Center

Mazur, Gertrud S., Ed.

The following papers of relevance to second language instruction are compiled here: (1) "Bilingual Math in a Monolingual Classroom: A Field Study," by Elizabeth M. Baricevic; (2) "Ideologie et pedagogie: reflexions sur le manuel de francais au programme de '3e annee secondaire' en Algerie," by Jeanne Adam; (3) "Pedagogic…

Registration of conventional soybean germplasm JTN-4307 with resistance to nematodes and fungal diseases

USDA-ARS?s Scientific Manuscript database

JTN-4307 soybean [Glycine max (L.) Merr.] (Reg. No. XX-XXX, PI 670017) was developed by USDA-ARS in collaboration with the University of Missouri and the University of Tennessee, and released in 2013, for its broad resistance to soybean cyst nematode (Heterodera glycines Ichinohe), reniform nematode...

X Chromosome Abnormalities and Cognitive Development: Implications for Understanding Normal Human Development.

ERIC Educational Resources Information Center

Walzer, Stanley

1985-01-01

Argues that knowledge from studies of individuals with sex chromosome abnormalities can further understanding of aspects of normal human development. Studies of XO girls, XXY boys, XXX girls, and males with a fragile X chromosome are summarized to demonstrate how results contribute to knowledge about normal cognitive development and about…

Twisting singular solutions of Betheʼs equations

NASA Astrophysics Data System (ADS)

Nepomechie, Rafael I.; Wang, Chunguang

2014-12-01

The Bethe equations for the periodic XXX and XXZ spin chains admit singular solutions, for which the corresponding eigenvalues and eigenvectors are ill-defined. We use a twist regularization to derive conditions for such singular solutions to be physical, in which case they correspond to genuine eigenvalues and eigenvectors of the Hamiltonian.

Report of the AD HOC Committee on Patent Documentation.

ERIC Educational Resources Information Center

Urbach, Peter; And Others

The Committee was established in September 1967 to study and make recommendations on Recommendation XXIX and XXX of the Report of the President's Commission on the Patent System. Based on interviews with Patent Office officials, patent examiners and classifiers and a review of Patent Office studies and documents, the Committee concluded that the…

Medicinal flowers. XXX. Eight new glycosides, everlastosides F-M, from the flowers of Helichrysum arenarium.

PubMed

Morikawa, Toshio; Wang, Li-Bo; Ninomiya, Kiyofumi; Nakamura, Seikou; Matsuda, Hisashi; Muraoka, Osamu; Wu, Li-Jun; Yoshikawa, Masayuki

2009-08-01

Eight new glycosides, everlastosides F (1), G (2), H (3), I (4), J (5), K (6), L (7), and M (8), were isolated from the methanolic extract of the flowers of Helichrysum arenarium. Their structures were elucidated on the basis of chemical and physicochemical evidence.

Registration of three soybean germplasm lines resistant to Phakopsora pachyrhizi (soybean rust)

USDA-ARS?s Scientific Manuscript database

Soybean rust, caused by Phakopsora pachyrhizi Sydow, is one of the most important foliar diseases of soybean [Glycine max (L.)Merr.]. Development of rust resistant lines is one objective of many soybean breeding programs. Three soybean germplasm lines esignated as TGx 1987-76F (Reg. No. xxx, PI 6577...

Registration of JTN-5203 soybean germplasm with resistance to multiple cyst nematode populations

USDA-ARS?s Scientific Manuscript database

JTN-5203 soybean [Glycine max (L.) Merr.] (Reg. No. XX-XXX, PI 664903) was developed and released by USDA-ARS in collaboration with the University of Tennessee in 2012 for its broad resistance to soybean cyst nematode (SCN; Heterodera glycines Ichinohe), as well as reniform nematode (Rotylenchulus ...

Children's Theatre Review, Volume XXX, Number 2, Spring 1981. Research Edition.

ERIC Educational Resources Information Center

Ritch, Pamela, Ed.

1981-01-01

This special journal edition contains research reports on children and the theatre. The seven articles discuss the following subjects: (1) how audiences function in participation plays for young people, (2) creative dramatics and handicapped children, (3) the effect of advance organizers on children's responses to theatre viewing, (4) a Piagetian…

9 CFR 313.1 - Livestock pens, driveways and ramps.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) Livestock pens, driveways and ramps shall be maintained in good repair. They shall be free from sharp or... acceptable construction and maintenance. (c) U.S. Suspects (as defined in § 301.2(xxx)) and dying, diseased... awaiting disposition by the inspector. (d) Livestock pens and driveways shall be so arranged that sharp...

48 CFR 752.7003 - Documentation for payment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... information to be reported with the following elements: Total Expenditures [Document Number: XXX-X-XX-XXXX-XX.... for Line Item 001 $XXXX.XX $ XXXX.XX 002 Product/Service Desc. for Line Item 002 XXXX.XX XXXX.XX Total XXXX.XX XXXX.XX (2) The fiscal report shall include the following certification signed by an authorized...

Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bai, Lin; Hu, Kuan; Wang, Tong

Here, the human pathogen Mycobacterium tuberculosis ( Mtb) requires a proteasome system to cause lethal infections in mice. We recently found that proteasome accessory factor E (PafE, Rv3780) activates proteolysis by the Mtb proteasome independently of adenosine triphosphate (ATP). Moreover, PafE contributes to the heat-shock response and virulence of Mtb. Here, we show that PafE subunits formed four-helix bundles similar to those of the eukaryotic ATP-independent proteasome activator subunits of PA26 and PA28. However, unlike any other known proteasome activator, PafE formed dodecamers with 12-fold symmetry, which required a glycine-XXX-glycine-XXX-glycine motif that is not found in previously described activators. Intriguingly,more » the truncation of the PafE carboxyl-terminus resulted in the robust binding of PafE rings to native proteasome core particles and substantially increased proteasomal activity, suggesting that the extended carboxyl-terminus of this cofactor confers suboptimal binding to the proteasome core particle. Collectively, our data show that proteasomal activation is not limited to hexameric ATPases in bacteria.« less

New Intermetallic Ternary Phosphide Chalcogenide AP2-xXx (A = Zr, Hf; X = S, Se) Superconductors with PbFCl-Type Crystal Structure

NASA Astrophysics Data System (ADS)

Kitô, Hijiri; Yanagi, Yousuke; Ishida, Shigeyuki; Oka, Kunihiko; Gotoh, Yoshito; Fujihisa, Hiroshi; Yoshida, Yoshiyuki; Iyo, Akira; Eisaki, Hiroshi

2014-07-01

We have synthesized a series of intermetallic ternary phosphide chalcogenide superconductors, AP2-xXx (A = Zr, Hf; X = S, Se), using the high-pressure synthesis technique. These materials have a PbFCl-type crystal structure (space group P4/nmm) when x is greater than 0.3. The superconducting transition temperature Tc changes systematically with x, yielding dome-like phase diagrams. The maximum Tc is achieved at approximately x = 0.7, at which point the Tc is 6.3 K for ZrP2-xSex (x = 0.75), 5.5 K for HfP2-xSex (x = 0.7), 5.0 K for ZrP2-xSx (x = 0.675), and 4.6 K for Hfp2-xSx (x = 0.5). They are typical type-II superconductors and the upper and lower critical fields are estimated to be 2.92 T at 0 K and 0.021 T at 2 K for ZrP2-xSex (x = 0.75), respectively.

Fatigue behavior of a 2XXX series aluminum alloy reinforced with 15 vol Pct SiCp

NASA Astrophysics Data System (ADS)

Bonnen, J. J.; Allison, J. E.; Jones, J. W.

1991-05-01

The fatigue behavior of a naturally aged powder metallurgy 2xxx series aluminum alloy (Alcoa MB85) and a composite made of this alloy with 15 vol pct SiCp, has been investigated. Fatigue lives were determined using load-controlled axial testing of unnotched cylindrical samples. The influence of mean stress was determined at stress ratios of -1, 0.1, and 0.7. Mean stress had a significant influence on fatigue life, and this influence was consistent with that normally observed in metals. At each stress ratio, the incorporation of SiC reinforcement led to an increase in fatigue life at low and intermediate stresses. When considered on a strain-life basis, however, the composite materials had a somewhat inferior resistance to fatigue. Fatigue cracks initiated from several different microstructural features or defect types, but fatigue life did not vary significantly with the specific initiation site. As the fatigue crack advanced away from the fatigue crack initiation site, increasing numbers of SiC particles were fractured, in agreement with crack-tip process zone models.

Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis

DOE PAGES

Bai, Lin; Hu, Kuan; Wang, Tong; ...

2016-03-21

Here, the human pathogen Mycobacterium tuberculosis ( Mtb) requires a proteasome system to cause lethal infections in mice. We recently found that proteasome accessory factor E (PafE, Rv3780) activates proteolysis by the Mtb proteasome independently of adenosine triphosphate (ATP). Moreover, PafE contributes to the heat-shock response and virulence of Mtb. Here, we show that PafE subunits formed four-helix bundles similar to those of the eukaryotic ATP-independent proteasome activator subunits of PA26 and PA28. However, unlike any other known proteasome activator, PafE formed dodecamers with 12-fold symmetry, which required a glycine-XXX-glycine-XXX-glycine motif that is not found in previously described activators. Intriguingly,more » the truncation of the PafE carboxyl-terminus resulted in the robust binding of PafE rings to native proteasome core particles and substantially increased proteasomal activity, suggesting that the extended carboxyl-terminus of this cofactor confers suboptimal binding to the proteasome core particle. Collectively, our data show that proteasomal activation is not limited to hexameric ATPases in bacteria.« less

Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR

PubMed Central

Grace, Christy Rani R.; Erchegyi, Judit; Koerber, Steven C.; Reubi, Jean Claude; Rivier, Jean; Riek, Roland

2008-01-01

The three-dimensional NMR structures of six octapeptide agonist analogues of somatostatin (SRIF) in the free form are described. These analogues, with the basic sequence H-DPhe/Phe2-c[Cys3-Xxx7-DTrp8-Lys9-Thr10-Cys14]-Thr-NH2 (the numbering refers to the position in native SRIF), with Xxx7 being Ala/Aph, exhibit potent and highly selective binding to human SRIF type 2 (sst2) receptors. The backbone of these sst2-selective analogues have the usual type-II’ β-turn reported in the literature for sst2/3/5-subtype-selective analogues. Correlating biological results and NMR studies led to the identification of the side chains of DPhe2, DTrp8 and Lys9 as the necessary components of the sst2 pharmacophore. This is the first study to show that the aromatic ring at position 7 (Phe7) is not critical for sst2 binding and that it plays an important role in sst3 and sst5 binding. This pharmacophore is therefore different from that proposed by others for sst2/3/5 analogues. PMID:16854054

Comparative studies of social buffering: A consideration of approaches, terminology, and pitfalls.

PubMed

Kiyokawa, Yasushi; Hennessy, Michael B

2018-03-01

KIYOKAWA, Y. and HENNESSY, M.B. Comparative studies of social buffering: A consideration of approaches, terminology, and pitfalls…NEUROSCI BIOBEHAV REV XXX-XXX, .- Over the past decades, there has been an increasing number of investigations of the impact of social variables on neural, endocrine, and immune outcomes. Among these are studies of "social buffering"-or the phenomenon by which affiliative social partners mitigate the response to stressors. Yet, as social buffering studies have become more commonplace, the variety of approaches taken, definitions employed, and divergent results obtained in different species can lead to confusion and miscommunication. The aim of the present paper, therefore, is to address terminology and approaches and to highlight potential pitfalls to the study of social buffering across nonhuman species. We review and categorize variables currently being employed in social buffering studies and provide an overview of responses measured, mediating sensory modalities and underlying mechanisms. It is our hope that the paper will be useful to those contemplating examination of social buffering in the context of their own research. Copyright © 2017 Elsevier Ltd. All rights reserved.

A Study on Tooling and Its Effect on Heat Generation and Mechanical Properties of Welded Joints in Friction Stir Welding

NASA Astrophysics Data System (ADS)

Tikader, Sujoy; Biswas, Pankaj; Puri, Asit Baran

2018-04-01

Friction stir welding (FSW) has been the most attracting solid state welding process as it serves numerous advantages like good mechanical, metallurgical properties etc. Non weldable aluminium alloys like 5XXX, 7XXX series can be simply joined by this process. In this present study a mathematical model has been developed and experiments were successfully performed to evaluate mechanical properties of FSW on similar aluminium alloys i.e. AA1100 for different process parameters and mainly two kind of tool geometry (straight cylindrical and conical or cylindrical tapered shaped pin with flat shoulder). Tensile strength and micro hardness for different process parameters are reported of the welded plate sample. It was noticed that in FSW of similar alloy with tool made of SS-310 tool steel, friction is the major contributor for the heat generation. It was seen that tool geometry, tool rotational speed, plunging force by the tool and traverse speed have significant effect on tensile strength and hardness of friction stir welded joints.

Monitoring and modeling of sinkhole-related subsidence in west-central Florida mapped from InSAR and surface observations

NASA Astrophysics Data System (ADS)

Kiflu, H.; Oliver-Cabrera, T.; Robinson, T.; Wdowinski, S.; Kruse, S.

2017-12-01

Sinkholes in Florida cause millions of dollars in damage to infrastructure each year. Methods of early detection of sinkhole-related subsidence are clearly desirable. We have completed two years of monitoring of selected sinkhole-prone areas in west central Florida with XXX data and analysis with XXX algorithms. Filters for selecting targets with high signal-to-noise ratio and subsidence over this time window (XX-2015-XX-2017) are being used to select sites for ground study. A subset of the buildings with InSAR-detected subsidence indicated show clear structural indications of subsidence in the form of cracks in walls and roofs. Comsol Multiphysics models have been developed to describe subsidence at the rates identified from the InSAR analysis (a few mm/year) and on spatial scales observed from surface observations, including structural deformation of buildings and ground penetrating radar images of subsurface deformation (length scales of meters to tens of meters). These models assume cylindrical symmetry and deformation of elastic and poroelastic layers over a growing sphering void.

Clinical details, cytogenic studies,and cellular physiology of a 69, XXX fetus, with comments on the biological effect of triploidy in man.

PubMed Central

Gosden, C M; Wright, M O; Paterson, W G; Grant, K A

1976-01-01

A triploid fetus, 69, XXX, aborted spontaneously at 26 weeks' gestation. It had multiple abnormalities including syndactyly of the hands and feet single palmar creases, hypoplasia of the adrenals and ovaries, hypertrophy of thigh muscles, and abnormalities of the brain. The placenta was large and showed hydatidiform degeneration. The pregnancy had been complicated by acute dyspnoea, pre-eclampsia, and postpartum haemorrhage. Detailed cytogenetic studies, using banding and fluorescence techniques, were performed on fetus and parents. Meiotic studies were made on the fetal ovaries. Muscle cell differentiation and electrophysiological relationships of cultured skin fibriblasts were examined in an attempt to study the way in which the extra haploid set of chromosomes exerts its effect on the phenotype. The antenatal diagnosis of late triploidy is discussed. The finding that 25 per cent of late triploids have spina bifida is further evidence that meningomyelocele has a genetic component and strongly suggests that this results from chromosomal imbalance or a regulatory gene disturbance. Images PMID:1034015

Unusual Turner syndrome mosaic with a triple x cell line (47,X/49,XXX) in a western lowland gorilla (Gorilla gorilla gorilla).

PubMed

Bradford, Carol M; Tupa, Lynn; Wiese, Debbie; Hurley, Timothy J; Zimmerman, Ralph

2013-12-01

A 29-yr-old female western lowland gorilla (Gorilla gorilla gorilla) was evaluated for low fertility and a midterm abortion. Laboratory testing included karyotyping, which revealed an unusual mosaicism for Turner syndrome with Triple X (47,X/49,XXX). This appears to be the first report of Turner syndrome in a great ape. In humans, Turner syndrome occurs in approximately 1 in 3,000 females, with half of those monosomic for the X chromosome. A small proportion is mosaic for a triple X cell line (3-4%). In humans, Turner syndrome is associated with characteristic phenotype including short stature, obesity, a broad chest with widely spaced nipples, webbing of the neck, and anteverted ears. This individual gorilla is significantly shorter in stature than conspecifics and is obese despite normal caloric intake. Individuals with Turner syndrome should also be screened for common health issues, including congenital heart defects, obesity, kidney abnormalities, hypertension, hypothyroidism, and diabetes mellitus. Animals with decreased fertility, multiple miscarriages, fetal losses, unusual phenotypes, or a combination of these symptoms should be evaluated for genetic abnormalities.

Al-Li-Cu-Mg-(Ag) Products for Lower Wing Skin Applications

NASA Astrophysics Data System (ADS)

Karabin, L. M.; Bray, G. H.; Rioja, R. J.; Venema, G.

Al-Li-Cu-Mg alloy products, with and without Ag additions provide substantial performance advantages over conventional 2xxx products. For lower wing applications, the combination of specific ultimate tensile strength and damage tolerance is of particular importance and this is an area in which the Al-Li alloys can excel. Since Al-Li products have historically suffered with issues surrounding high property gradients through the plate thickness and high degrees of tensile in-plane anisotropy, a great deal of attention has been paid to the thermo-mechanical processing routes used in the fabrication of the current generation of alloy products. In addition, corrosion resistance is an area that has received greater attention recently since it can impact inspection intervals. In this presentation, the microstructures and properties of two new alloy products aimed for lower wing applications, 2199-T86 and 2060-T8E86, will be reviewed and compared with non-Li 2xxx products. It is concluded that the performance improvements of Al-Li alloys/products in addition to their lower density will enable significant weight savings in modern aircraft.

Spectra of Mo XXX, XXXI, and XXXII from a laser-produced plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burkhalter, P.G.; Reader, J.; Cowan, R.D.

1977-11-01

Spectra of highly charged Mo ions generated in a laser-produced plasma were observed from 10 to 190 A with a 3 m grazing- incidence spectrograph. Line identifications in Mo XXX-- XXXII were made with the help of relativistic Hartree-Fock calculations. In Mo XXXI (Mg-like) the 3s/sup 2/ /sup 1/S/sub 0/--3s3p /sup 1/P/sub 1/ resonance line was found to be at 115.944 A. In Mo XXXII (Na-like) the 3s /sup 2/S/sub 1/2/--3p /sup 2/P/sub 3/2,1/2/ resonance lines are at 127.814 and 176.62 A. These values support the recent identifications of these lines in the Princeton ST tokamak by Hinnov. The density-sensitivemore » 3p /sup 2/P/sub 3/2/--3d /sup 2/D/sub 5/2/ transition in Mo XXXII is at 126.937 A. At shorter wavelengths, the 3s--4p transitions of Mo XXXII are at 14.384 and 14.565 A.« less

[ital n]=5 to [ital n]=5 soft-x-ray emission of uranium in a high-temperature low-density tokamak plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fournier, K.B.; Finkenthal, M.; Lippmann, S.

1994-11-01

The soft-x-ray uranium emission in the 60--200-A range recorded from a high-temperature ([similar to]1 keV) low-density ([similar to]10[sup 13] cm[sup [minus]3]) tokamak plasma has been analyzed by comparison with theoretical level structure and line-intensity calculations. In an extension of previous work [Finkenthal [ital et] [ital al]., Phys. Rev. A 45, 5846 (1992)], theoretical U XXV, U XXX, U XXXI, and U XXXII [ital n]=5 to [ital n]=5 spectra have been computed for the relevant plasma parameters. Fully relativistic parametric potential computer codes have been used for the [ital ab] [ital initio] atomic-structure calculations, and electron-impact excitation rates have been computedmore » in the distorted-wave approximation. 5[ital s]-5[ital p] spectral lines and quasicontinua of U XXX, U XXXI, and U XXXII are identified in the 165--200-A wavelength band. An unambiguous line identification is hampered by theoretical uncertainties and the blending of emission from adjacent charge states.« less

CH/sub 3/xxx/sup 13/CO/sub 2/ pairs in irradiated single crystals of CH/sub 3//sup 13/CO/sub 2/Lix2D/sub 2/0. [Gamma rays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Toriyama, K.; Iwasaki, M.

1976-10-01

The CH/sub 3/ radical trapped in irradiated single crystals of CH/sub 3//sup 13/CO/sub 2/Lix2D/sub 2/O has been found to interact with a /sup 13/CO/sub 2/ molecule, which is formed from the C--C bond breakage as a counterpart. The /sup 13/C superhyperfine coupling tensor was determined to be (-4.0, -3.3, -3.5) G. The /sup 13/CO/sub 2/ molecule is located in the direction of the unpaired electron orbital of CH/sub 3/ with the molecular axis perpendicular to it. The spectrum arising from the electron excess center CH/sub 3/ /sup 13/CO/sub 2//sup 2 -/ was also detected together with the CH/sub 3/ radical.more » Our results indicate that the CH/sub 3/xxx/sup 13/CO/sub 2/ pair is essentially a positive hole center formed from one electron loss followed by the C--C bond breakage. (AIP)« less

Finite field equation of Yang--Mills theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brandt, R.A.; Wing-Chiu, N.; Yeung, W.

1980-03-01

We consider the finite local field equation -)(1+1/..cap alpha.. (1+f/sub 4/))g/sup munu/D'Alembertian-partial/sup ..mu../partial/sup ..nu../)A/sup nua/ =-(1+f/sub 3/) g/sup 2/N(A/sup c/..nu..A/sup a/..mu..A/sub ..nu..//sup c/) +xxx+(1-s)/sup 2/M/sup 2/A/sup a/..mu.., introduced by Lowenstein to rigorously describe SU(2) Yang--Mills theory, which is written in terms of normal products. We also consider the operator product expansion A/sup c/..nu..(x+xi) A/sup a/..mu..(x) A/sup b/lambda(x-xi) approx...sigma..M/sup c/ab..nu mu..lambda/sub c/'a'b'..nu..'..mu..'lambda' (xi) N(A/sup nuprimec/'A/sup muprimea/'A/sup lambdaprimeb/')(x), and using asymptotic freedom, we compute the leading behavior of the Wilson coefficients M/sup ...//sub .../(xi) with the help of a computer, and express the normal products in the field equation in terms ofmore » products of the c-number Wilson coefficients and of operator products like A/sup c/..nu..(x+xi) A/sup a/..mu..(x) A/sup b/lambda(x-xi) at separated points. Our result is -)(1+(1/..cap alpha..)(1+f/sub 4/))g/sup munu/D'Alembertian-partial/sup ..mu../partial/sup ..nu../)A/sup nua/ =-(1+f/sub 3/) g/sup 2/lim/sub xiarrow-right0/) (lnxi)/sup -0.28/2b/(A/sup c/..nu.. (x+xi) A/sup a/..mu..(x) A/sub ..nu..//sup c/(x-xi) +epsilon/sup a/bcA/sup muc/(x+xi) partial/sup ..nu../A/sup b//sub ..nu../(x)+xxx) +xxx)+(1-s)/sup 2/M/sup 2/A/sup a/..mu.., where ..beta.. (g) =-bg/sup 3/, and so (lnxi)/sup -0.28/2b/ is the leading behavior of the c-number coefficient multiplying the operator products in the field equation.« less

Comparison of Present Day and Historical Dispersal Patterns in the Western Adriatic

DTIC Science & Technology

2005-09-30

319, 1996. Sherwood, C.R., S. Carniel, L. Cavaleri, J. Chiggiato , H. Das, J. Doyle, C.K. Harris, A. Niedoroda, J. Pullen, C.W. Reed, A. Russo, M...Event, EOS, XXX. [published, refereed]. Sherwood, C.R., S. Carniel, L. Cavaleri, J. Chiggiato , H. Das, J.D. Doyle, C.K. Harris, A.W. Neidoroda, J

78 FR 69123 - Draft Long Range Transportation Plan for U.S. Fish and Wildlife Service Lands in the Midwest Region

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-18

... decision-making. Establish a vision, mission, goals, and objectives for transportation planning in the... as a pilot project for the implementation of a region-level transportation planning process within... DEPARTMENT OF THE INTERIOR Fish and Wildlife Service [FWS-R3-R-2012-N270; FXRS85550300000-XXX...

Registration of an oilseed sunflower germplasm HA-DM1 resistant to sunflower downy mildew

USDA-ARS?s Scientific Manuscript database

HA-DM1 (Reg. No.xxx, PI 674793) sunflower (Helianthus annuus L.) germplasm was developed and released cooperatively by the USDA-ARS, Sunflower and Plant Biology Research Unit and the North Dakota Agricultural Experiment Station in 2015. HA-DM1 is a BC2F4 derived oilseed maintainer line from the cros...

Registration of a male fertility restorer oilseed sunflower germplasm HA-R9 resistant to sunflower rust

USDA-ARS?s Scientific Manuscript database

The sunflower (Helianthus annuus L.) germplasm HA-R9 (Reg. No.xxx, PI 667595) was developed by the USDA-ARS, Sunflower and Plant Biology Research Unit in collaboration with the Agricultural Experiment Station of North Dakota State University and released in January, 2013. Sunflower rust (caused by P...

Barrels XXX meeting report: Barrels in Baltimore.

PubMed

Shin, Hyeyoung; Bitzidou, Malamati; Palaguachi, Fernando; Brumberg, Joshua C

2018-03-01

The Barrels meeting annually brings together researchers focused on the rodent whisker to cortical barrel system prior to the Society for Neuroscience meeting. The 2017 meeting focused on the classification of cortical interneurons, the role interneurons have in shaping brain dynamics, and finally on the circuitry underlying oral sensations. The meeting highlighted the latest advancements in this rapidly advancing field.

[Research of imidazo[1,2-a]benzimidazole derivatives. XXX. Synthesis and properties of (imidazo[1,2-a]benzimidazolyl-2)acetic acid derivatives].

PubMed

Anisimova, V A; Tolpygin, I E; Spasov, A A; Serdiuk, T S; Sukhov, A G

2011-01-01

Ethyl esters of (9-subtituted-imidazo[1,2-a]benzimidazolyl-2)acetic acids were synthesized. The chemical properties of these esters (hydrolysis, decarboxylation, hydrazinolysis) and biological activity (fungicidal, antimicrobial, antiarrhythmic activity, and also affects on the brain rhythmogenesis) of the prepared compounds were studied.

Gas tungsten arc welding of aluminum alloys 6XXX. Welding procedure specification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wodtke, C.H.; Frizzell, D.R.; Plunkett, W.A.

1985-08-01

Procedure WPS-1003 is qualified under Section IX of the ASME Boiler and Pressure Vessel Code for gas tungsten arc welding of aluminum alloys 6061 and 6063 (P-23), in thickness range 0.035 to 0.516 in.; filler metal is ER4043 (F-23) or ER5356 (F-22); shielding gas is argon.

AUTOMOTIVE DIESEL MAINTENANCE 1. UNIT XXX, I--CATERPILLAR DIESEL ENGINE MAINTENANCE SUMMARY, II--REIEWING FACTS ABOUT ALTERNATORS.

ERIC Educational Resources Information Center

Minnesota State Dept. of Education, St. Paul. Div. of Vocational and Technical Education.

THIS MODULE OF A 30-MODULE COURSE IS DESIGNED TO PROVIDE A SUMMARY OF DIESEL ENGINE MAINTENANCE FACTORS AND A REVIEW OF DIESEL ENGINE ALTERNATOR OPERATION. THE SEVEN SECTIONS COVER DIESEL ENGINE TROUBLESHOOTING AND THE OPERATION, TESTING, AND ADJUSTING OF ALTERNATORS. THE MODULE CONSISTS OF A SELF-INSTRUCTIONAL BRANCH PROGRAMED TRAINING FILM…

Federal Logistics Information System (FLIS). Volume 18. Automated Mailing Labels System (AMLS) FLIS Procedures Manual

DTIC Science & Technology

1993-07-01

LPLPW3t TIME XXXX\\ LISI ADDRESSES AND DISIRIBUTION FOR XX XXXXXXXXXXXXXXXXXX\\ LSER ID XXX P %G[ ZZ.zz9 AA MLG MAILING ADDRESS ZIP CODE PI C x XNXX XX...4100.39-M Volume Is APPENDIX C AMLS INFORMATIONAL MESSAGES Corrective Action: Press the F6 ( COM MIT) function key to add the Distribution information

Neurocognitive Outcomes of Individuals with a Sex Chromosome Trisomy: XXX, XYY, or XXY--A Systematic Review

ERIC Educational Resources Information Center

Leggett, Victoria; Jacobs, Patricia; Nation, Kate; Scerif, Gaia; Bishop, Dorothy V. M.

2010-01-01

Aim: To review systematically the neurodevelopmental characteristics of individuals with sex chromosome trisomies (SCTs). Method: A bibliographic search identified English-language articles on SCTs. The focus was on studies unbiased by clinical referral, with power of at least 0.69 to detect an effect size of 1.0. Results: We identified 35…

Comparative anatomy of the female genitalia of generic-level taxa in tribe Aedini (Diptera: Culicidae). Part XXX. Genus Gilesius Reinert, Harbach and Kitching.

USDA-ARS?s Scientific Manuscript database

A morphological analysis of the female genitalia of species included in genus Gilesius Reinert, Harbach and Kitching was conducted. The genitalia of the type species of the genus, Gi. pulchriventer (Giles), are illustrated for the first time. Treatment of the genital morphology of the genus includ...

Applications of the Theory of Work Adjustment to Rehabilitation and Counseling. Minnesota Studies in Vocational Rehabilitation: XXX.

ERIC Educational Resources Information Center

Lofquist, Lloyd H.; Dawis, Rene V.

This is one of a series of 30 monographs documenting the progress and accomplishments of the Minnesota Work Adjustment Project. Presented in this, the final report, is an overview of the project as well as detailed explanations of outcomes and activities. The conceptualized Work Adjustment Theory is the foremost accomplishment of the research…

Social Media in the Classroom: A Simple yet Complex Hybrid Environment for Students

ERIC Educational Resources Information Center

Casey, Gail

2013-01-01

This article reports on part of the author's PhD action research study. It examines the complexity of features that social media and Web 2.0 offer when combined with face-to-face teaching and learning. Action research was used to help redesign the learning programs of XXX's thirteen Middle Years classes over an eighteen month period. These…

77 FR 7174 - Correction Notice for Deepwater Horizon Oil Spill; Draft Phase I Early Restoration Plan and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-10

... DEPARTMENT OF THE INTERIOR Fish and Wildlife Service [FWS-R4-FHC-2012-N030; FVHC98130406900Y4-XXX-FF04G01000] Correction Notice for Deepwater Horizon Oil Spill; Draft Phase I Early Restoration Plan and Environmental Assessment AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of availability and request...

77 FR 3489 - Proposed Information Collection; Wildlife and Sport Fish Grants and Cooperative Agreements

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-24

...-FF09W11000/ FVWF51100900000-XXX-FF09W11000] Proposed Information Collection; Wildlife and Sport Fish Grants... (email) or (703) 358-2482 (telephone). SUPPLEMENTARY INFORMATION: I. Abstract. The Wildlife and Sport... Training). 15.605 Sport Fish Restoration. 16 U.S.C. 777 et seq. 50 CFR 80. except 777e-1 and g-1. [[Page...

A Comparison of Microstructure and Properties of Equivalent Strength Ingot Metallurgy and Powder Metallurgy 7XXX Aluminum Alloys.

DTIC Science & Technology

1981-08-01

electron microprobe analysis and other laboratory procedures is also acknowledged. The author recognizes the considerable contributions of Ms. Cheryl ...J. Knott , Acta Met., 23, (7), (1975), 841. 473. A. Tetelman and A. McEvily, op. cit. 474. J. Feeney and J. McMillan and R. Wei, Met. Trans., 1, (1970

The Magic of Words Reconsidered: Investigating the Automaticity of Reading Color-Neutral Words in the Stroop Task

ERIC Educational Resources Information Center

Kinoshita, Sachiko; De Wit, Bianca; Norris, Dennis

2017-01-01

In 2 variants of the color-word Stroop task, we compared 5 types of color-neutral distractors--real words (e.g., "HAT"), pseudowords (e.g., "HIX"), consonant strings (e.g., "HDK"), symbol strings (e.g., #$%), and a row of Xs (e.g., "XXX")--as well as incongruent color words (e.g., "GREEN" displayed…

77 FR 41075 - Delegation of National Emission Standards for Hazardous Air Pollutants for Source Categories...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-12

..., and Sulfur Recovery Units. VVV Publicly Owned X X X X Treatment Works. XXX Ferroalloys X X X X... Ceramics X X X X Manufacturing. LLLLL Asphalt Roofing X X X X and Processing. MMMMM Flexible X X X X... Source X Standards for Aluminum, Copper, and Other Nonferrous Foundries. AAAAAAA Asphalt X Processing and...

Establishment of the National Maritime Intelligence Center: Understanding the Foundations of Trust to Support a Collaborative Environment in Homeland Security

DTIC Science & Technology

2010-03-01

this project would not have been possible without the love and support of my wife, Lacey, and my great kids , Madeline, Kenny, and Jackson. Thank you...and the interagency: Knowledge and Speed vs. Ignorance and Sloth? Parameters, XXX (3), 66–76. United Kingdom House of Commons. The Butler Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park, I.Y.; Tirziu, A.; Tseytlin, A.A.

We consider circular strings rotating with equal spins S{sub 1}=S{sub 2}=S in two orthogonal planes in AdS{sub 5} and suggest that they may be dual to long gauge-theory operators built out of self-dual components of gauge field strength. As was found in hep-th/0404187, the one-loop anomalous dimensions of the such gauge-theory operators are described by an antiferromagnetic XXX{sub 1} spin chain and scale linearly with length L>>1. We find that in the case of rigid rotating string both the classical energy E{sub 0} and the 1-loop string correction E{sub 1} depend linearly on the spin S (within the stability regionmore » of the solution). This supports the identification of the rigid rotating string with the gauge-theory operator corresponding to the maximal-spin (ferromagnetic) state of the XXX{sub 1} spin chain. The energy of more general rotating and pulsating strings also happens to scale linearly with both the spin and the oscillation number. Such solutions should be dual to other lower-spin states of the spin chain, with the antiferromagnetic ground state presumably corresponding to the string pulsating in two planes with no rotation.« less

Enhanced Microbial Survivability in Subzero Brines.

PubMed

Heinz, Jacob; Schirmack, Janosch; Airo, Alessandro; Kounaves, Samuel P; Schulze-Makuch, Dirk

2018-04-17

It is well known that dissolved salts can significantly lower the freezing point of water and thus extend habitability to subzero conditions. However, most investigations thus far have focused on sodium chloride as a solute. In this study, we report on the survivability of the bacterial strain Planococcus halocryophilus in sodium, magnesium, and calcium chloride or perchlorate solutions at temperatures ranging from +25°C to -30°C. In addition, we determined the survival rates of P. halocryophilus when subjected to multiple freeze/thaw cycles. We found that cells suspended in chloride-containing samples have markedly increased survival rates compared with those in perchlorate-containing samples. In both cases, the survival rates increase with lower temperatures; however, this effect is more pronounced in chloride-containing samples. Furthermore, we found that higher salt concentrations increase survival rates when cells are subjected to freeze/thaw cycles. Our findings have important implications not only for the habitability of cold environments on Earth but also for extraterrestrial environments such as that of Mars, where cold brines might exist in the subsurface and perhaps even appear temporarily at the surface such as at recurring slope lineae. Key Words: Brines-Halophile-Mars-Perchlorate-Subzero-Survival. Astrobiology 18, xxx-xxx.

Pattern of (Multi)strange (Anti)baryon Production and Search for Deconfinement

NASA Astrophysics Data System (ADS)

Rafelski, Johann

1998-04-01

We study (multi)strange particle abundances obtained recently in relativistic heavy ion collisions and determine thermal and chemical source parameters(J. Letessier et al., Phys. Lett. B410 (1997) 315--322 hep-ph/9710310 and: Acta Physica Polonica in press, hep- ph/9710340). These are primarily constrained by (multi)strange (anti)baryon relative abundances, which have been measured for Pb--Pb 158 A GeV interactions(I. Kralik, for WA97 collaboration, QM97 Tsukuba, to appear in Nucl. Phys. A) and S-S/W/Pb 200 A GeV interactions(See: proceedings of S'96-Budapest, APH N.S., Heavy Ion Physics 4 (1996) vii--x). We have extended our analysis and have now determined the properties of the particle source using the fitted macro canonical parameters, allowing as required for non-equilibrium dynamics of the locally thermal fireball. We find that in the 158 A GeV Pb--Pb collisions the entropy per baryon, energy per baryon, strangeness per baryon implied by particle spectra are all in the range of values associated commonly with the deconfined QGP phase.

On determinant representations of scalar products and form factors in the SoV approach: the XXX case

NASA Astrophysics Data System (ADS)

Kitanine, N.; Maillet, J. M.; Niccoli, G.; Terras, V.

2016-03-01

In the present article we study the form factors of quantum integrable lattice models solvable by the separation of variables (SoVs) method. It was recently shown that these models admit universal determinant representations for the scalar products of the so-called separate states (a class which includes in particular all the eigenstates of the transfer matrix). These results permit to obtain simple expressions for the matrix elements of local operators (form factors). However, these representations have been obtained up to now only for the completely inhomogeneous versions of the lattice models considered. In this article we give a simple algebraic procedure to rewrite the scalar products (and hence the form factors) for the SoV related models as Izergin or Slavnov type determinants. This new form leads to simple expressions for the form factors in the homogeneous and thermodynamic limits. To make the presentation of our method clear, we have chosen to explain it first for the simple case of the XXX Heisenberg chain with anti-periodic boundary conditions. We would nevertheless like to stress that the approach presented in this article applies as well to a wide range of models solved in the SoV framework.

A case of 45,X/47,XXX mosaic Turner syndrome with limb length discrepancy.

PubMed

Hishimura-Yonemaru, Nozomi; Okuhara, Koji; Takahashi, Nobuhiro; Tonoki, Hidefumi; Iizuka, Susumu; Tajima, Toshihiro

2017-01-01

Patients with Turner syndrome (TS) frequently show short stature and skeletal deformities, such as kyphosis and scoliosis. However, to the best of our knowledge, limb length discrepancy (LLD) has not yet been reported in patients with TS. The case of a 12-yr-old girl with 45,X/47,XXX mosaic TS showing LLD is herein presented. She was on GH therapy for short stature and was noted to have scoliosis in the standing position at a regular examination; however, the scoliosis became less evident in the supine position, which is indicative of LLD. The length of the left leg was 5.0 cm shorter than that of the right leg when measured. She was referred to orthopedics and underwent right distal femoral and right proximal tibial staple epiphysiodesis to shorten the abnormally long limb at 10 yr 6 mo of age. One year after the operation, the LLD decreased from 5.0 to 1.5 cm. During this period, GH was continued. LLD is a rare complication in TS, but when patients with TS show scoliosis in the standing position, re-evaluation for scoliosis in the supine position should be performed and the lengths of both legs should be measured.

Calculations with spectroscopic accuracy for energies, transition rates, hyperfine interaction constants, and Landé gJ-factors in nitrogen-like Kr XXX

NASA Astrophysics Data System (ADS)

Wang, K.; Li, S.; Jönsson, P.; Fu, N.; Dang, W.; Guo, X. L.; Chen, C. Y.; Yan, J.; Chen, Z. B.; Si, R.

2017-01-01

Extensive self-consistent multi-configuration Dirac-Fock (MCDF) calculations and second-order many-body perturbation theory (MBPT) calculations are performed for the lowest 272 states belonging to the 2s22p3, 2s2p4, 2p5, 2s22p23l, and 2s2p33l (l=s, p, d) configurations of N-like Kr XXX. Complete and consistent data sets of level energies, wavelengths, line strengths, oscillator strengths, lifetimes, AJ, BJ hyperfine interaction constants, Landé gJ-factors, and electric dipole (E1), magnetic dipole (M1), electric quadrupole (E2), magnetic quadrupole (M2) transition rates among all these levels are given. The present MCDF and MBPT results are compared with each other and with other available experimental and theoretical results. The mean relative difference between our two sets of level energies is only about 0.003% for these 272 levels. The accuracy of the present calculations are high enough to facilitate identification of many observed spectral lines. These accurate data can be served as benchmark for other calculations and can be useful for fusion plasma research and astrophysical applications.

Examination of the Teaching Styles of Nursing Professional Development Specialists, Part II: Correlational Study on Teaching Styles and Use of Adult Learning Theory.

PubMed

Curran, Mary K

2014-07-16

This article, the second in a two-part series, details a correlational study that examined the effects of four variables (graduate degrees in nursing education, professional development training in adult learning theory, nursing professional development [NPD] certification, and NPD specialist experience) on the use of adult learning theory to guide curriculum development. Using the Principles of Adult Learning Scale, 114 NPD specialists tested the hypothesis that NPD specialists with graduate degrees in nursing education, professional development training in adult learning theory, NPD certification, and NPD experience would use higher levels of adult learning theory in their teaching practices to guide curriculum development than those without these attributes. This hypothesis was rejected as regression analysis revealed only one statistically significant predictor variable, NPD certification, influenced the use of adult learning theory. In addition, analysis revealed NPD specialists tended to support a teacher-centered rather than a learner-centered teaching style, indicating NPD educators are not using adult learning theory to guide teaching practices and curriculum development. J Contin Educ Nurs. 2014;45(8):xxx-xxx. Copyright 2014, SLACK Incorporated.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jaruratanasirikul, S.; Jinorose, U.

The authors report on an infant with double trisomy 48,XXX,+18. She presented with manifestation of trisomy 18: prominent occiput, microphthalmia, small mouth, micrognathia, malformed ears, congenital heart defect, overlapping fingers, talipes equinovarus, and rockerbottom feet. An extra palmar crease was present only on the right hand. This patient was alive at 12 months. The clinical manifestations are compared with those of 10 previously reported cases. 13 refs., 3 figs., 1 tab.

Survival in Double Aneuploidy Involving Trisomy 18 and Sex Chromosome Trisomy: A Case Report of a 27-month-old Child and a Review of the Literature.

PubMed

Watabe, Takahide; Koga, Hiroshi

2018-05-07

Maternal meiotic nondisjunction can cause autosomal trisomy, such as trisomy 13, 18, and 21, and parental meiotic nondisjunction or post-zygotic nondisjunction can cause sex chromosome trisomy, such as XXX (triple X syndrome), XXY (Klinefelter syndrome), and XYY (XYY syndrome). This article is protected by copyright. All rights reserved.

Defense Language Institute Russian Basic Course. Volumes XXVIII, Lessons 131-140. Volume XXX, Lessons 151-159.

ERIC Educational Resources Information Center

Defense Language Inst., Washington, DC.

The 19 lessons in these two volumes are intended for the advanced phase of a 159-lesson intensive audiolingual basic Russian course developed recently by the Defense Language Institute to train native speakers of English to a Level 3 second language proficiency. These third and fifth volumes contain such features as (1) texts on the Russian Civil…

Original and future cometary orbits. IV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marsden, B.G.

1990-06-01

The values of the original and future reciprocal semimajor axes are calulcated for 36 recent osculating cometary orbits. The results are compared with the computations of Yabushita and Hasegawa (1989). Adjustments for deriving original and future orbits are given for nine other recent comets for which only parabolic orbit determinations are available. Specific attention is given to the physical comet pair 1987 XXX/1988 III. 15 refs.

Detection of fetal sex chromosome aneuploidy by massively parallel sequencing of maternal plasma DNA: initial experience in a Chinese hospital.

PubMed

Yao, H; Jiang, F; Hu, H; Gao, Y; Zhu, Z; Zhang, H; Wang, Y; Guo, Y; Liu, L; Yuan, Y; Zhou, L; Wang, J; Du, B; Qu, N; Zhang, R; Dong, Y; Xu, H; Chen, F; Jiang, H; Liu, Y; Zhang, L; Tian, Z; Liu, Q; Zhang, C; Pan, X; Yang, S; Zhao, L; Wang, W; Liang, Z

2014-07-01

To evaluate the performance of a massively parallel sequencing (MPS)-based test in detecting fetal sex chromosome aneuploidy (SCA) and to present a comprehensive clinical counseling protocol for SCA-positive patients. This was a retrospective study in a large patient cohort of 5950 singleton pregnancies which underwent MPS-based testing as a prenatal screening test for trisomies 21, 18 and 13, with X and Y chromosomes as secondary findings, in Southwest Hospital in China. MPS-based SCA-positive women were offered the choice of knowing whether their SCA results were positive and those who did commenced a two-stage post-test clinical counseling protocol. In Stage 1, general information about SCA was given, and women were given the option of invasive testing for confirmation of findings; in Stage 2, those who had chosen to undergo invasive testing were informed about the specific SCA affecting their fetus and their management options. Thirty-three cases were classified as SCA-positive by MPS-based testing. After Stage 1 of the two-stage post-test clinical counseling session, 33 (100%) of these pregnant women chose to know the screening test results, and 25 (75.76%) underwent an invasive diagnostic procedure and karyotype analysis, in one of whom karyotyping failed. In thirteen cases, karyotyping confirmed the MPS-based test results (two X0 cases, seven XXX cases, three XXY cases and one XYY case), giving a positive predictive value of 54.17% (13/24 cases confirmed by karyotyping). After post-test clinical counseling session Stage 2, seven women chose to terminate the pregnancy: one X0 case, two XXX cases, the three XXY cases and the single XYY case. Six women decided to continue with pregnancy: one X0 case and five XXX cases. Our study showed the feasibility of clinical application of the MPS-based test in the non-invasive detection of fetal SCA. Together with a two-stage post-test clinical counseling protocol, it leads to a well-informed decision-making procedure. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd.

Epidemiology of double aneuploidies involving chromosome 21 and the sex chromosomes.

PubMed

Kovaleva, Natalia V; Mutton, David E

2005-04-01

The chance of two chromosome abnormalities occurring in one conceptus is very small. However, some authors have suggested that double aneuplodies (DAs) might be more common than the product of their individual frequencies. The nonrandomness of such DA events was considered to be evidence that nondisjunction (NDJ) may be genetically determined. Data collected from the National Down syndrome Cytogenetic Register (NDSCR) in England and Wales and from the literature indicate that the frequencies of all nonmosaic DAs, except for 48,XXY,+21, are lower than expected, probably because of strong intrauterine selection against such pregnancies. Collectively, we identified 52 cases of nonmosaic 48,XXY,+21; 28 cases of 48,XYY,+21; and 14 cases of 48,XXX,+21 in liveborns and 13 cases of 48,XXY,+21; four cases of 48,XYY,+21; and two cases of 48,XXX,+21 after prenatal diagnoses. Among these cases, analysis of the published unbiased cytogenetic surveys of liveborn DS revealed 24 cases of 48,XXY,+21; nine cases of 48,XYY,+21; and seven cases of 48,XXX,+21. These figures are different from the expected proportion of 1:1:1 (P < 0.001), with carriers of XXY overrepresented in the group of carriers of DA. Mechanisms put forth to account for the higher occurrence of 48,XXY,+21 may include greater accessibility of disomic ovum to Y-carrying sperm, and promotion of NDJ in ovum by Y-bearing sperm. 48,XXY,+21 DA was found to be age-dependent, as the proportion of mothers over age 35 (x = 33.0) was increased over the general population. This is in contrast to the apparently age-independent 48,XYY,+21 DA, with a mean maternal age of 24.7 (P < 0.001). Paternal ages were also remarkably different between the groups, with a mean age of 37.9 in 48,XXY,+21 cases and a mean age of 27.9 in 48,XYY,+21 cases (P < 0.01). Maternal age-related factors, rather than genetic predisposition, may play a more important role in the etiology of the most common DA, 48,XXY,+21.

Peak AAA fatty acid homolog contaminants present in the dietary supplement l-Tryptophan associated with the onset of eosinophilia-myalgia syndrome.

PubMed

Klarskov, Klaus; Gagnon, Hugo; Racine, Mathieu; Boudreault, Pierre-Luc; Normandin, Chad; Marsault, Eric; Gleich, Gerald J; Naylor, Stephen

2018-05-22

The eosinophilia-myalgia syndrome (EMS) outbreak that occurred in the USA and elsewhere in 1989 was caused by the ingestion of Showa Denko K.K. (SD) L-tryptophan (L-Trp). "Six compounds" detected in the L-Trp were reported as case-associated contaminants. Recently the final and most statistically significant contaminant, "Peak AAA" was structurally characterized. The "compound" was actually shown to be two structural isomers resulting from condensation reactions of L-Trp with fatty acids derived from the bacterial cell membrane. They were identified as the indole C-2 anteiso (AAA 1 -343) and linear (AAA 2 -343) aliphatic chain isomers. Based on those findings, we utilized a combination of on-line HPLC-electrospray ionization mass spectrometry (LC-MS), as well as both precursor and product ion tandem mass spectrometry (MS/MS) to facilitate identification of a homologous family of condensation products related to AAA 1 -343 and AAA 2 -343. We structurally characterized eight new AAA 1 -XXX/AAA 2 -XXX contaminants, where XXX represents the integer molecular ions of all the related homologs, differing by aliphatic chain length and isomer configuration. The contaminants were derived from the following fatty acids of the bacterial cell membrane, 5-methylheptanoic acid (anteiso-C8:0) for AAA 1 -315; n-octanoic acid (n-C8:0) for AAA 2 -315; 6-methyloctanoic acid (anteiso-C9:0) for AAA 1 -329; n-nonanoic acid (n-C9:0) for AAA 2 -329; 10-methyldodecanoic acid (anteiso-C13:0) for AAA 1 -385; n-tridecanoic acid (n-C13:0) for AAA 2 -385; 11-methyltridecanoic acid (anteiso-C14:0) for AAA 1 -399; and n-tetradecanoic acid (n-C14:0) for AAA 2 -399. The concentration levels for these contaminants were estimated to be 0.1-7.9 μg / 500 mg of an individual SD L-Trp tablet or capsule The structural similarity of these homologs to case-related contaminants of Spanish Toxic Oil Syndrome (TOS) is discussed. Copyright © 2018 Elsevier B.V. All rights reserved.

17 CFR 230.163 - Exemption from section 5(c) of the Act for certain communications by or on behalf of well-known...

Code of Federal Regulations, 2010 CFR

2010-04-01

... communication that is an offer made in reliance on this exemption will be a free writing prospectus as defined... complete information about the issuer and this offering. You may get these documents for free by visiting... prospectus after filing if you request it by calling toll-free 1-8[xx-xxx-xxxx]. (ii) The legend also may...

17 CFR 230.163 - Exemption from section 5(c) of the Act for certain communications by or on behalf of well-known...

Code of Federal Regulations, 2014 CFR

2014-04-01

... communication that is an offer made in reliance on this exemption will be a free writing prospectus as defined... complete information about the issuer and this offering. You may get these documents for free by visiting... prospectus after filing if you request it by calling toll-free 1-8[xx-xxx-xxxx]. (ii) The legend also may...

17 CFR 230.163 - Exemption from section 5(c) of the Act for certain communications by or on behalf of well-known...

Code of Federal Regulations, 2012 CFR

2012-04-01

... communication that is an offer made in reliance on this exemption will be a free writing prospectus as defined... complete information about the issuer and this offering. You may get these documents for free by visiting... prospectus after filing if you request it by calling toll-free 1-8[xx-xxx-xxxx]. (ii) The legend also may...

17 CFR 230.163 - Exemption from section 5(c) of the Act for certain communications by or on behalf of well-known...

Code of Federal Regulations, 2011 CFR

2011-04-01

... communication that is an offer made in reliance on this exemption will be a free writing prospectus as defined... complete information about the issuer and this offering. You may get these documents for free by visiting... prospectus after filing if you request it by calling toll-free 1-8[xx-xxx-xxxx]. (ii) The legend also may...

17 CFR 230.163 - Exemption from section 5(c) of the Act for certain communications by or on behalf of well-known...

Code of Federal Regulations, 2013 CFR

2013-04-01

... communication that is an offer made in reliance on this exemption will be a free writing prospectus as defined... complete information about the issuer and this offering. You may get these documents for free by visiting... prospectus after filing if you request it by calling toll-free 1-8[xx-xxx-xxxx]. (ii) The legend also may...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dighe, Kalpak Arvind

Several 40+ hour data records obtained in Oct 2010 from the Los Alamos Portable Pulser Facility (LAPP) Operational clocks show variations of {approx} 27 nsec. Several 16+ hour data records obtained in Aug 2010 from non-operational clocks like those used operationally from 2005 to the present show variations of {approx} 35 nsec. SLRE variability is xxx +/- yyy sec (std dev). SLRE occasionally show unusual events such as those discussed by Pongratz. We will continue to study and monitor.

Expedition 56 Preflight

NASA Image and Video Library

2018-06-06

wave farewell to family and friends as they depart the Cosmonaut Hotel to suit-up for their Soyuz launch to the International Space Station, Wednesday, June 6, 2018 in Baikonur, Kazakhstan. Launch of the Soyuz MS-09 is scheduled for XXXX Eastern Time (XXX Baikonur time) on June 6 and will send Prokopyev, Gerst, and Auñón-Chancellor on a six month mission aboard the International Space Station. Photo Credit: (NASA/Joel Kowsky)

75 FR 61046 - Airworthiness Directives; Bombardier-Rotax GmbH Type 912 F, 912 S, and 914 F Series Reciprocating...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-04

... identified in this AD from BRP-Rotax GmbH & Co. KG, Welser Strasse 32, A-4623 Gunskirchen, Austria. The... looking at the S/ N in the area indicated by XXX, following ``Made in Austria,'' as shown on Figure 2 of... 32, A-4623 Gunskirchen, Austria, or go to rotax-aircraft-engines.com for a copy of this service...

Slavnov and Gaudin-Korepin formulas for models without U (1) symmetry: the XXX chain on the segment

NASA Astrophysics Data System (ADS)

Belliard, S.; Pimenta, R. A.

2016-04-01

We consider the isotropic spin -\\frac{1}{2} Heisenberg chain with the most general integrable boundaries. The scalar product between the on-shell Bethe vector and its off-shell dual, obtained by means of the modified algebraic Bethe ansatz, is given by a modified Slavnov formula. The corresponding Gaudin-Korepin formula, i.e., the square of the norm, is also obtained.

The Application of Web-Based Teaching and Learning in Tertiary Institution--A Case Study in Hong Kong

ERIC Educational Resources Information Center

Fung, Alex C. W.; Fu, Frank H. K.; Cheung, W. S.

2005-01-01

The experience of a two-year project to promote the use of Web-based teaching and learning at XXX University was presented. A total of 68 courses over two semesters were included in the study. Surveys of students and teachers suggested that the quality of learning and teaching were improved. Over 80% of the students had used Web-based teaching and…

Evaluation report for toggle switches: Texas Instruments, Inc., Apollo-type, and Daven Measurements part number 45000-XXX, job order 32-139

NASA Technical Reports Server (NTRS)

Labberton, D.

1974-01-01

A preliminary evaluation of environmental capabilities was undertaken on toggle switches and on Apollo-type toggle switches. The purpose of this evaluation was to take a first look at their tested capabilities for the purpose of determining whether the candidate hardware appears to have a good chance of successfully completing a detailed envrionmental qualification test program.

The Corporation and the Campus; Corporate Support of Higher Education in the 1970's. Proceedings of the Academy of Political Science, Volume XXX, Number 1.

ERIC Educational Resources Information Center

Connery, Robert H., Ed.

The purpose of the conference was to bring together educational leaders, corporation executives, and spokesmen for minority groups to examine problems in higher education. The papers include: "The Urban Crisis," by Robert C. Wood, and Harriet A. Zuckerman; "Minority Groups," by Charles V. Hamilton; "The Community and the Campus," by Franklin H.…

Gas tungsten arc welding of aluminum alloys 6XXX. Welding procedure specification. Supplement 1. Records of procedure qualification tests. [6061 and 6063

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wodtke, C.H.; Frizzell, D.R.; Plunkett, W.A.

1986-06-01

Procedure WPS-1003 is qualified under Section IX of the ASME Boiler and Pressure Vessel Code for gas tungsten arc welding of aluminum alloys 6061 and 6063 (P-23), in thickness range 0.035 to 0.516 inch; filler metal is ER4043 (F-23) or ER5356 (F-22); shielding gas is argon.

Gas tungsten arc welding of aluminum alloys 1XXX and 3003 to 3004, 5052 and 5X54. Welding procedure specification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wodtke, C.H.; Frizzell, D.R.; Plunkett, W.A.

1985-08-01

Procedure WPS-2201 is qualified under Section IX of the ASME Boiler and Pressure Vessel for gas tungsten arc welding of aluminum alloys 1060, 1100, and 3003 (P-21) to 3004, 5052, 5154, and 5454 (P-22), in thickness range 0.062 to 0.5 in.; filler metal is ER5356 (F-22); shielding gas is argon.

Center of Excellence for Remote and Medically Under-Served Areas

DTIC Science & Technology

2008-04-11

was an experimental, quantitative , qualitative, descriptive research study related to audio, data and video transmission from the ambulance to the... posttest score. Both the pretest and posttest questions were generated randomly from a bank of XXX course-related test questions. The analysis below...shows the mean for the pretest , posttest , and difference scores for the classroom group, the virtual group, and the total group. (Note: Two of the

Crozer-Chester Medical Center Burn Research Projects

DTIC Science & Technology

2009-07-01

Dressing for Autogenous Skin Donor Sites” This study will compare the performance of an agreed upon dressing to the normal standard of care (Xeroform...resuscitation algorithm for the development of a closed loop resuscitation system. a. Complete project start-up activities (hiring and training of...collect data (Year 2, Quarter 1) Study 2, Protocol Title: “Evaluation of Xxx for Autogenous Skin Donor Sites” Task 1: Enroll up to 30 patients in

Microstructure/mechanical property relationships for various thermal treatments of Al-Cu-Mg-X PM aluminum alloys

NASA Technical Reports Server (NTRS)

Blackburn, L. B.

1986-01-01

The thermal response and aging behavior of three 2XXX-series powder metallurgy aluminum alloys have been investigated, using Rockwell B hardness measurements, optical and electron microscopy, and energy-dispersive chemical analysis, in order to correlate microstructure with measured mechanical properties. Results of the thermal response study indicated that an increased solution heat treatment temperature was effective in resolutionizing large primary constituents in the alloy bearing more copper but had no apparent effect on the microconstituents of the other two. Aging studies conducted at room temperature and at 120, 150, and 180 C for times ranging up to 60 days indicated that classic aging response curves, as determined by hardness measurements, occurred at lower aging temperatures than were previously studied for these alloys, as well as at lower aging temperatures than are commonly used for ingot metallurgy alloys of similar compositions. Microstructural examination and fracture surface analysis of peak-aged tension specimens indicated that the highest tensile strengths are associated with extremely fine and homogeneous distributions of theta-prime or S-prime phases combined with low levels of both large constituent particles and dispersoids. Examination of the results suggest that refined solution heat treatments and lower aging temperatures may be necessary to achieve optimum mechanical properties for these 2XXX series alloys.

Rett syndrome in a 47,XXX patient with a de novo MECP2 mutation.

PubMed

Hammer, Sara; Dorrani, Naghmeh; Hartiala, Jaana; Stein, Stuart; Schanen, N Carolyn

2003-10-15

Rett syndrome is caused by mutation in MECP2, a gene located on Xq28 and subject to X-inactivation. MECP2 encodes methyl CpG-binding protein 2, a widely expressed transcriptional repressor of methylated DNA. Mutations in MECP2 are primarily de novo events in the male germ line and thus lead to an excess of affected females. Here we report the identification of a unique 47,XXX girl with relatively mild atypical Rett syndrome leading initially to a diagnosis of infantile autism with regression. Mutation analysis of the MECP2 gene identified a de novo MECP2 mutation, L100V. Examination of a panel of X-linked microsatellite markers indicated that her supernumerary X chromosome is maternally derived. X-inactivation patterns were determined by analysis of methylation of the androgen receptor locus, and indicated preferential inactivation of her paternal allele. The parental origin of her MECP2 mutation could not be determined because she was uninformative for intronic polymorphisms flanking her mutation. This is the first reported case of sex chromosome trisomy and MECP2 mutation in a female, and it illustrates the importance of allele dosage on the severity of Rett syndrome phenotype. Copyright 2003 Wiley-Liss, Inc.

A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands.

PubMed

Ericson, Mark D; Freeman, Katie T; Schnell, Sathya M; Haskell-Luevano, Carrie

2017-01-26

The melanocortin system consists of five receptor subtypes, endogenous agonists, and naturally occurring antagonists. These receptors and ligands have been implicated in numerous biological pathways including processes linked to obesity and food intake. Herein, a truncation structure-activity relationship study of chimeric agouti-related protein (AGRP)/[Nle4,DPhe7]α-melanocyte stimulating hormone (NDP-MSH) ligands is reported. The tetrapeptide His-DPhe-Arg-Trp or tripeptide DPhe-Arg-Trp replaced the Arg-Phe-Phe sequence in the AGRP active loop derivative c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro], where Xxx was the native Asn of AGRP or a diaminopropionic (Dap) acid residue previously shown to increase antagonist potency at the mMC4R. The Phe, Ala, and Dap/Asn residues were successively removed to generate a 14-member library that was assayed for agonist activity at the mouse MC1R, MC3R, MC4R, and MC5R. Two compounds possessed nanomolar agonist potency at the mMC4R, c[Pro-His-DPhe-Arg-Trp-Asn-Ala-Phe-DPro] and c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro], and may be further developed to generate novel melanocortin probes and ligands for understanding and treating obesity.

Reactivity to interpersonal stress in patients with eating disorders: A systematic review and meta-analysis of studies using an experimental paradigm.

PubMed

Monteleone, Alessio Maria; Treasure, Janet; Kan, Carol; Cardi, Valentina

2018-04-01

Reactivity to interpersonal stress in patients with eating disorders: A systematic review and meta-analysis of studies using an experimental paradigm. NEUROSCI BIOBEHAV REV XXX-XXX, 2018.- Social difficulties have been implicated in the development and maintenance of eating disorder symptoms. The aim of this work was to conduct a systematic review and meta-analysis of experimental studies testing patientsö reactivity to interpersonal stress, compared to healthy controls. Thirty-four studies were included. Meta-analyses were conducted on 16 studies and on following outcomes: attention bias and interference to threatening faces, cortisol, heart rate and negative affect before and after exposure to interpersonal stress. Patients showed heightened attention bias and interference to threatening faces. Lower heart rate after exposure to interpersonal stress and greater negative affect before and after interpersonal stress were observed in the clinical group compared to controls. Surprisingly, only a small minority of studies included measures of abnormal eating behaviour and attitudes. This seems a missed opportunity for testing the causal and maintaining role that abnormalities in interpersonal stress response play in eating disorders. Nonetheless, findings corroborate the hypothesis that patients' response to interpersonal stress differs from that of healthy controls. Copyright © 2018 Elsevier Ltd. All rights reserved.

A hybrid aluminium alloy and its zoo of interacting nano-precipitates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wenner, Sigurd, E-mail: sigurd.wenner@ntnu.no; Marioara, Calin Daniel; Andersen, Sigmund Jarle

An alloy with aluminium as its base element is heat treated to form a multitude of precipitate phases known from different classes of industrial alloys: Al–Cu(–Mg), Al–Mg–Si–Cu, and Al–Zn–Mg. Nanometer-sized needle-shaped particles define the starting point of the phase nucleation, after which there is a split in the precipitation sequence into six phases of highly diverse compositions and morphologies. There are several unique effects of phases from different alloy systems being present in the same host lattice, of which we concentrate on two: the replacement of Ag by Zn on the Ω interface and the formation of combined plates ofmore » the θ′ and C phases. Using atomically resolved scanning transmission electron microscopy and energy-dispersive X-ray spectroscopy, we investigate the formation mechanisms, crystal structures and compositions of the precipitates. - Graphical abstract: Display Omitted - Highlights: • An aluminium alloy composition in-between the 2/6/7xxx systems was investigated. • Six different phases from the three systems coexist in an over-aged state. • All phases with 〈001〉{sub Al} coherencies can nucleate on 6xxx needle precipitates. • Modified theta′ and omega interfaces are observed.« less

Multiple functional attributes of glucose-monitoring neurons in the medial orbitofrontal (ventrolateral prefrontal) cortex.

PubMed

Szabó, István; Hormay, Edina; Csetényi, Bettina; Nagy, Bernadett; Lénárd, László; Karádi, Zoltán

2018-02-01

Multiple functional attributes of glucose-monitoring neurons in the medial orbitofrontal (ventrolateral prefrontal) cortex. NEUROSCI BIOBEHAV REV 73(1) XXX-XXX, 2017.- Special chemosensory cells, the glucose-monitoring (GM) neurons, reportedly involved in the central feeding control, exist in the medial orbitofrontal (ventrolateral prefrontal) cortex (mVLPFC). Electrophysiological, metabolic and behavioral studies reveal complex functional attributes of these cells and raise their homeostatic significance. Single neuron recordings, by means of the multibarreled microelectrophoretic technique, elucidate differential sensitivities of limbic forebrain neurons in the rat and the rhesus monkey to glucose and other chemicals, whereas gustatory stimulations demonstrate their distinct taste responsiveness. Metabolic examinations provide evidence for alteration of blood glucose level in glucose tolerance test and elevation of plasma triglyceride concentration after destruction of the local GM cells by streptozotocin (STZ). In behavioral studies, STZ microinjection into the mVLPFC fails to interfere with the acquisition of saccharin conditioned taste avoidance, does cause, however, taste perception deficit in taste reactivity tests. Multiple functional attributes of GM neurons in the mVLPFC, within the frame of the hierarchically organized central GM neuronal network, appear to play important role in the maintenance of the homeostatic balance. Copyright © 2017 Elsevier Ltd. All rights reserved.

Anatomical insights into the interaction of emotion and cognition in the prefrontal cortex

PubMed Central

Ray, Rebecca; Zald, David H.

2011-01-01

Ray, R. and D. Zald. Anatomical insights into the interaction of emotion and cognition in the prefrontal cortex. NEUROSCI BIOBEHAV REV 36(X) XXX-XXX, 2011. -Psychological research increasingly indicates that emotional processes interact with other aspects of cognition. Studies have demonstrated both the ability of emotional stimuli to influence a broad range of cognitive operations, and the ability of humans to use top-down cognitive control mechanisms to regulate emotional responses. Portions of the prefrontal cortex appear to play a significant role in these interactions. However, the manner in which these interactions are implemented remains only partially elucidated. In the present review we describe the anatomical connections between ventral and dorsal prefrontal areas as well as their connections with limbic regions. Only a subset of prefrontal areas are likely to directly influence amygdalar processing, and as such models of prefrontal control of emotions and models of emotional regulation should be constrained to plausible pathways of influence. We also focus on how the specific pattern of feedforward and feedback connections between these regions may dictate the nature of information flow between ventral and dorsal prefrontal areas and the amygdala. These patterns of connections are inconsistent with several commonly expressed assumptions about the nature of communications between emotion and cognition. PMID:21889953

Strategies for Detecting Biological Molecules on Titan.

PubMed

Neish, Catherine D; Lorenz, Ralph D; Turtle, Elizabeth P; Barnes, Jason W; Trainer, Melissa G; Stiles, Bryan; Kirk, Randolph; Hibbitts, Charles A; Malaska, Michael J

2018-05-02

Saturn's moon Titan has all the ingredients needed to produce "life as we know it." When exposed to liquid water, organic molecules analogous to those found on Titan produce a range of biomolecules such as amino acids. Titan thus provides a natural laboratory for studying the products of prebiotic chemistry. In this work, we examine the ideal locales to search for evidence of, or progression toward, life on Titan. We determine that the best sites to identify biological molecules are deposits of impact melt on the floors of large, fresh impact craters, specifically Sinlap, Selk, and Menrva craters. We find that it is not possible to identify biomolecules on Titan through remote sensing, but rather through in situ measurements capable of identifying a wide range of biological molecules. Given the nonuniformity of impact melt exposures on the floor of a weathered impact crater, the ideal lander would be capable of precision targeting. This would allow it to identify the locations of fresh impact melt deposits, and/or sites where the melt deposits have been exposed through erosion or mass wasting. Determining the extent of prebiotic chemistry within these melt deposits would help us to understand how life could originate on a world very different from Earth. Key Words: Titan-Prebiotic chemistry-Solar system exploration-Impact processes-Volcanism. Astrobiology xx, xxx-xxx.

An evaluation of the benefits of utilizing rapid solidification for development of 2XXX (Al-Cu-Mg) alloys

NASA Technical Reports Server (NTRS)

Paris, H. G.; Chellman, D. J.

1986-01-01

The advantages of rapid solidification processing over ingot metallurgy processing in the development of 2XXX aluminum alloy compositions were evaluated using a similarly processed ingot metallurgy (IM) control alloy. The powder metallurgy (PM) alloy extrusions showed a reduced age-hardening response in comparison with similar IM compositions, with higher tensile properties for naturally aged extrusions but lower properties for artificially aged ones. However, the tensile properties of naturally and artificially aged PM alloy extrusions based on a version of IM 2034 alloy, but containing 0.6 weight percent zirconium, were comparable to those of the IM control extrusions and had significantly superior combinations of strength and toughness. The tensile properties of this PM alloy showed even greater advantage in 6.4-mm (0.25-in.) and 1.8-mm (0.070-in.) plate and sheet, the yield strength being about 68 MPa (10 ksi) greater than reported values for the IM 2034 alloy sheet. An artificially aged PM alloy based on 2219 alloy also showed a strength and strength-toughness combination comparable to those of the PM Al-Cu-Mg-Zr alloy, substantially outperforming the IM 2219 alloy. These results show that rapid solidification offers the flexibility needed to modify conventional IM compositions to produce new alloy compositions with superior mechanical properties.

A case of 45,X/47,XXX mosaic Turner syndrome with limb length discrepancy

PubMed Central

Hishimura-Yonemaru, Nozomi; Okuhara, Koji; Takahashi, Nobuhiro; Tonoki, Hidefumi; Iizuka, Susumu; Tajima, Toshihiro

2017-01-01

Abstract. Patients with Turner syndrome (TS) frequently show short stature and skeletal deformities, such as kyphosis and scoliosis. However, to the best of our knowledge, limb length discrepancy (LLD) has not yet been reported in patients with TS. The case of a 12-yr-old girl with 45,X/47,XXX mosaic TS showing LLD is herein presented. She was on GH therapy for short stature and was noted to have scoliosis in the standing position at a regular examination; however, the scoliosis became less evident in the supine position, which is indicative of LLD. The length of the left leg was 5.0 cm shorter than that of the right leg when measured. She was referred to orthopedics and underwent right distal femoral and right proximal tibial staple epiphysiodesis to shorten the abnormally long limb at 10 yr 6 mo of age. One year after the operation, the LLD decreased from 5.0 to 1.5 cm. During this period, GH was continued. LLD is a rare complication in TS, but when patients with TS show scoliosis in the standing position, re-evaluation for scoliosis in the supine position should be performed and the lengths of both legs should be measured. PMID:29026275

Multiple Quantum Coherences (MQ) NMR and Entanglement Dynamics in the Mixed-Three-Spin XXX Heisenberg Model with Single-Ion Anisotropy

NASA Astrophysics Data System (ADS)

Hamid, Arian Zad

2016-12-01

We analytically investigate Multiple Quantum (MQ) NMR dynamics in a mixed-three-spin (1/2,1,1/2) system with XXX Heisenberg model at the front of an external homogeneous magnetic field B. A single-ion anisotropy property ζ is considered for the spin-1. The intensities dependence of MQ NMR coherences on their orders (zeroth and second orders) for two pairs of spins (1,1/2) and (1/2,1/2) of the favorite tripartite system are obtained. It is also investigated dynamics of the pairwise quantum entanglement for the bipartite (sub)systems (1,1/2) and (1/2,1/2) permanently coupled by, respectively, coupling constants J}1 and J}2, by means of concurrence and fidelity. Then, some straightforward comparisons are done between these quantities and the intensities of MQ NMR coherences and ultimately some interesting results are reported. We also show that the time evolution of MQ coherences based on the reduced density matrix of the pair spins (1,1/2) is closely connected with the dynamics of the pairwise entanglement. Finally, we prove that one can introduce MQ coherence of the zeroth order corresponds to the pair spins (1,1/2) as an entanglement witness at some special time intervals.

Local Self-Similarity and Finite-Time Singularity in a High-Symmetry Euler Flow

NASA Astrophysics Data System (ADS)

Ng, C. S.; Bhattacharjee, A.

1997-11-01

The dynamical consequence of a positive fourth-order pressure derivative (p_xxxx) at the origin [C. S. Ng and A. Bhattacharjee, Phys. Rev. E 54 1530, 1996] in a high-symmetry Euler flow (the Kida flow) is considered. It is shown that the third order spatial derivative u_xxx of the x component of the velocity u at the origin is always decreasing in this situation. By assuming that u_xxx always attains a minimum possible value consistent with a given spectral profile, it is found that the flow is locally self-similar near the origin and collapses as energy cascades to Fourier modes with higher wavenumbers k. Moreover, it is found that the self-similar p(x) and u(x) profiles (as well as their derivatives) near the origin are very similar in shape to what were found in numerical simulations [O. N. Boratav and R. B. Pelz, Phys. Fluids 6 2757, 1994]. It is shown that a finite-time singularity (FTS) must appear in this case if the spectral index ν of the energy spectrum E(k) ∝ k^-ν of the locally self-similar flow is less than 6. A self-similar solution satisfying the Kelvin's theorem of circulation trivially has ν = 2 with vortex filaments and a FTS.

Generalized epilepsy in a patient with mosaic Turner syndrome: a case report.

PubMed

Jhang, Kai-Ming; Chang, Tung-Ming; Chen, Ming; Liu, Chin-San

2014-04-02

Reports on cases of epilepsy in Turner syndrome are rare and most of them have cortical developmental malformations. We report the case of a Taiwanese patient with mosaic Turner syndrome with generalized tonic-clonic epilepsy and asymmetrical lateral ventricles but no apparent cortical anomaly. A 49-year-old Taiwanese woman without family history presented with infrequent generalized tonic-clonic epilepsy since she was 11 years old. On examination, her short stature, webbed neck, swelling of hands and feet, retrognathic face, and mild intellectual disability were noted. She had spontaneous menarche and regular menses. Brain magnetic resonance imaging showed asymmetrical lateral ventricles and diffuse subcortical white matter T2-weighted hyperintensities. Chromosome studies disclosed low aneuploid (10%) 45,X/46,XX/47,XXX mosaic Turner syndrome. There is increasing evidence that epilepsy can be an uncommon presentation of Turner syndrome. Mosaic Turner syndrome with 47, XXX probably increases the risk of epilepsy but more research is needed to reach a conclusion. This case also strengthens our knowledge that Turner syndrome can be one of the pathologic bases of asymmetrical lateral ventricles. When a patient has idiopathic/cryptogenic epilepsy or asymmetrical lateral ventricles on brain images, the presence of a mild Turner phenotype warrants further chromosome studies.

The Ladder of Life Detection.

PubMed

Neveu, Marc; Hays, Lindsay E; Voytek, Mary A; New, Michael H; Schulte, Mitchell D

2018-06-04

We describe the history and features of the Ladder of Life Detection, a tool intended to guide the design of investigations to detect microbial life within the practical constraints of robotic space missions. To build the Ladder, we have drawn from lessons learned from previous attempts at detecting life and derived criteria for a measurement (or suite of measurements) to constitute convincing evidence for indigenous life. We summarize features of life as we know it, how specific they are to life, and how they can be measured, and sort these features in a general sense based on their likelihood of indicating life. Because indigenous life is the hypothesis of last resort in interpreting life-detection measurements, we propose a small but expandable set of decision rules determining whether the abiotic hypothesis is disproved. In light of these rules, we evaluate past and upcoming attempts at life detection. The Ladder of Life Detection is not intended to endorse specific biosignatures or instruments for life-detection measurements, and is by no means a definitive, final product. It is intended as a starting point to stimulate discussion, debate, and further research on the characteristics of life, what constitutes a biosignature, and the means to measure them. Key Words: Life detection-Life-detection instruments-Biosignatures-Biomarkers. Astrobiology 18, xxx-xxx.

A System Dynamics Model for Assessing the Cost-Effectiveness of USAF Engineering Officer Compensation Policies.

DTIC Science & Technology

1980-12-01

VI and jA-VI] [p. 46]. This article also gives a pertinent quote attributed to Vroom . job satisfaction is closely affected by the amounts of rewards...Presentation of Typical QOAFL Question . . . . 40 6. Comparison of Mean Quality of Air Force Life Factor Satisfaction Levels . ....... . 41 7...Scientific Officers (AFSCs 2XXX) ...... ................ . 150 A-II. Mean Values of Satisfaction and Importance Ratings of Job Characteristics, and Their

Second cluster integral from the spectrum of an infinite XXZ spin chain

NASA Astrophysics Data System (ADS)

Bibikov, P. N.

2015-03-01

First and second terms of the low-temperature cluster expansion for the free energy density of a magnetically polarized XXZ spin chain is obtained within the propagator approach suggested by E.W. Montroll and J.C. Ward. All the calculations employ only one- and two-magnon infinite-chain spectrums. In the XXX-point the result reproduces the well known S. Katsura's formula obtained 50 years ago by finite-chain calculations.

Crystallographic interpretation of Galois symmetries for magnetic pentagonal ring

NASA Astrophysics Data System (ADS)

Milewski, J.; Lulek, T.; Łabuz, M.

2017-03-01

Galois symmetry of exact Bethe Ansatz eigenstates for the magnetic pentagonal ring within the XXX model are investigated by a comparison with crystallographic constructions of space groups. It follows that the arithmetic symmetry of Bethe parameters for the interior of the Brillouin zone admits crystallographic interpretation, in terms of the periodic square Z2 ×Z2 , that is the two-dimensional crystal lattice with Born-Karman period two in both directions.

Direct evidence of a multicentre halogen bond: unexpected contraction of the P-XXX-P fragment in triphenylphosphine dihalides.

PubMed

Nikitin, Kirill; Müller-Bunz, Helge; Gilheany, Declan

2013-02-18

Triphenylhalophosphonium halides, Ph(3)PX(2), form crystals comprising bridged linear cations [Ph(3)P-X-X-X-PPh(3)](+) where the X(3) bridge is shortened from 6.56 Å in Cl-Cl-Cl to 6.37 Å in the Br-Br-Br system. It is proposed that this structure is stabilised by five-centre/six-electron (5c-6e) hypervalent interactions.

Registration of N614, A3N615, N616, and N617 Shattercane Genetic Stocks with cytoplasmic or nuclear male-sterility and juicy or dry midribs

USDA-ARS?s Scientific Manuscript database

Four shattercane [Sorghum bicolor subsp. drummondii (Nees ex Steud) de Wet & Harlan] genetic stocks, N614, A3N615, N616, N617 (Reg. No. XXX, PI 665683 to 665686), with A3 cytoplasmic male-sterility or nuclear male-sterility gene ms3 containing either juicy (dd) or dry (DD) culms were developed joint...

Federal Funds for Research and Development: Fiscal Years 1980, 1981, and 1982, Volume XXX. Final Report. Surveys of Science Resources Series.

ERIC Educational Resources Information Center

National Science Foundation, Washington, DC. Div. of Science Resources Studies.

This report is the 30th in a series that covers research and development (R&D) as shown in successive Presidential budgets. The Federal budget for 1982 was unusual in the extent to which it was subjected to change, reflecting the new administration's philosophy to reduce Federal spending. R&D funding data reflect the first series of 1981…

On the Kirchhoff Index of Graphs

NASA Astrophysics Data System (ADS)

Das, Kinkar C.

2013-09-01

Let G be a connected graph of order n with Laplacian eigenvalues μ1 ≥ μ2 ≥ ... ≥ μn-1 > mn = 0. The Kirchhoff index of G is defined as [xxx] In this paper. we give lower and upper bounds on Kf of graphs in terms on n, number of edges, maximum degree, and number of spanning trees. Moreover, we present lower and upper bounds on the Nordhaus-Gaddum-type result for the Kirchhoff index.

Study on effects of powder and flake chemistry and morphology on the properties of Al-Cu-Mg-X-X-X powder metallurgy advanced aluminum alloys

NASA Technical Reports Server (NTRS)

Meschter, P. J.; Lederich, R. J.; Oneal, J. E.

1986-01-01

A study was conducted: (1) to develop rapid solidification processed (RSP) dispersoid-containing Al-3Cu-2Li-1Mg-0.2Zr alloys as substitutes for titanium alloys and commercial 2XXX aluminum alloys for service to at least 150 C; and (2) to develop RSP Al-4Li-Cu-Mg-Zr alloys as substitutes for high-strength commercial 7XXX alloys in ambient-temperature applications. RSP Al-3Cu-2Li-1Mg-0.2Zr alloys have density-normalized yield stresses at 150 C up to 52% larger than that of 2124-T851 and up to 30% larger than that of Ti-6Al-4V. Strength at 150 C in these alloys is provided by thermally stable delta' (Al3Li), T1 (Al2LiCu), and S' (Al2CuMg) precipitates. Density-normalized yield stresses of RSP Al-3Cu-2Li-1Mg-0.2Zr alloys are up to 100% larger than that of 2124-T851 and equivalent to that of Al-8Fe-4Ce at 260 C. Strength in the RSP alloys at 260 C is provided by incoherent dispersoids and subboundary constituent particles such as T1 and S. The RSP alloys are attractive substitutes in less than or = 100-h exposures for 2xxx and Al-4Fe-Ce alloys up to 260 C and for titanium alloys up to 150 C. RSP Al-4Li-Cu-Mg-Zr alloys have ambient-temperature yield and ultimate tensile stresses similar to that of 7050-T7651, and are 14% less dense. RSP Al-4Li-0.5Cu-1.5Mg-0.2Zr has a 20% higher specific yield stress, 40% higher specific elastic modulus, and superior corrosion resistance compared to the properties of 7050-T7651. Strength in the Al-4Li-Cu-Mg-Zr alloy class is primarily provided by the substructure and delta' precipitates and is independent of Cu:Mg ratio. Improvements in fracture toughness and transverse-orientation properties in both alloy classes depend on improved melt practices to eliminate oxide inclusions which are incorporated into the consolidated forms.

Renormalization of loop functions for all loops

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brandt, R.A.; Neri, F.; Sato, M.

1981-08-15

It is shown that the vacuum expectation values W(C/sub 1/,xxx, C/sub n/) of products of the traces of the path-ordered phase factors P exp(igcontour-integral/sub C/iA/sub ..mu../(x)dx/sup ..mu../) are multiplicatively renormalizable in all orders of perturbation theory. Here A/sub ..mu../(x) are the vector gauge field matrices in the non-Abelian gauge theory with gauge group U(N) or SU(N), and C/sub i/ are loops (closed paths). When the loops are smooth (i.e., differentiable) and simple (i.e., non-self-intersecting), it has been shown that the generally divergent loop functions W become finite functions W when expressed in terms of the renormalized coupling constant and multipliedmore » by the factors e/sup -K/L(C/sub i/), where K is linearly divergent and L(C/sub i/) is the length of C/sub i/. It is proved here that the loop functions remain multiplicatively renormalizable even if the curves have any finite number of cusps (points of nondifferentiability) or cross points (points of self-intersection). If C/sub ..gamma../ is a loop which is smooth and simple except for a single cusp of angle ..gamma.., then W/sub R/(C/sub ..gamma../) = Z(..gamma..)W(C/sub ..gamma../) is finite for a suitable renormalization factor Z(..gamma..) which depends on ..gamma.. but on no other characteristic of C/sub ..gamma../. This statement is made precise by introducing a regularization, or via a loop-integrand subtraction scheme specified by a normalization condition W/sub R/(C-bar/sub ..gamma../) = 1 for an arbitrary but fixed loop C-bar/sub ..gamma../. Next, if C/sub ..beta../ is a loop which is smooth and simple except for a cross point of angles ..beta.., then W(C/sub ..beta../) must be renormalized together with the loop functions of associated sets S/sup i//sub ..beta../ = )C/sup i//sub 1/,xxx, C/sup i//sub p/i) (i = 2,xxx,I) of loops C/sup i//sub q/ which coincide with certain parts of C/sub ..beta../equivalentC/sup 1//sub 1/. Then W/sub R/(S/sup i//sub ..beta../) = Z/sup i/j(..beta..)W(S/sup j//sub ..beta../) is finite for a suitable matrix Z/sup i/j(..beta..).« less

The Role of Stress in the Corrosion Cracking of Aluminum Alloys

DTIC Science & Technology

2013-03-01

Corrosion IGSCC Intergranular Stress Corrosion Cracking NAMLT Nitric Acid Mass Loss Test SCC Stress Corrosion Cracking TGSCC Transgranular Stress...solution at a nitric acid mass loss test (NAMLT) value of 49 mg/cm 2 with an applied voltage of 0.73 VSCE. They also showed that the amount of corrosion ...for determining the susceptibility to intergranualr corrosion of 5XXX series aluminum alloys by mass loss after exposure to nitric acid ," vol.

The Role of Jedburgh Teams in Operations Market Garden

DTIC Science & Technology

1990-06-01

with XXX Corps, the British 1st Airborne encountered powerful opposition at Arnhem and sustained heavy losses . (6) Five Jedburgh teams deployed to...stored in a suitcase with its accessories (total weight of suitcase: 9 pounds). This device had a five watt output with a range of 500 miles. For...rather than of real operational need-the need for a formation of sufficient status to ensure that airborne operations were given their full weight . (32

Ultrasound imaging for the rheumatologist XXX. Sonographic assessment of the painful knee.

PubMed

Meenagh, G; Filippucci, E; Delle Sedie, A; Iagnocco, A; Scirè, C A; Riente, L; Montecucco, C; Valesini, G; Bombardieri, S; Grassi, W

2010-01-01

The knee joint is a frequent focus of attention for rheumatologists when assessing patients presenting to a clinic and may represent underlying intra-articular inflammatory pathology or involvement of the surrounding soft tissues. This study describes the correlation between clinical and ultrasound findings in patients presenting with a variety of rheumatic disorders and knee pain. US imaging provides for a sensitive and detailed identification of different intra- and peri-articular pathology responsible for knee pain.

Algorithm XXX : functions to support the IEEE standard for binary floating-point arithmetic.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cody, W. J.; Mathematics and Computer Science

1993-12-01

This paper describes C programs for the support functions copysign(x,y), logb(x), scalb(x,n), nextafter(x,y), finite(x), and isnan(x) recommended in the Appendix to the IEEE Standard for Binary Floating-Point Arithmetic. In the case of logb, the modified definition given in the later IEEE Standard for Radix-Independent Floating-Point Arithmetic is followed. These programs should run without modification on most systems conforming to the binary standard.

Genetic diagnosis of sex chromosome aberrations in horses based on parentage test by microsatellite DNA and analysis of X- and Y-linked markers.

PubMed

Kakoi, H; Hirota, K; Gawahara, H; Kurosawa, M; Kuwajima, M

2005-03-01

Sex chromosome aberrations are often associated with clinical signs that affect equine health and reproduction. However, abnormal manifestation with sex chromosome aberration usually appears at maturity and potential disorders may be suspected infrequently. A reliable survey at an early stage is therefore required. To detect and characterise sex chromosome aberrations in newborn foals by the parentage test and analysis using X- and Y-linked markers. We conducted a genetic diagnosis combined with a parentage test by microsatellite DNA and analysis of X- and Y-linked genetic markers in newborn light-breed foals (n = 17, 471). The minimum incidence of sex chromosome aberration in horses was estimated in the context of available population data. Eighteen cases with aberrations involving 63,XO, 65,XXY and 65,XXX were found. The XO, XXY (pure 65,XXY and/or mosaics/chimaeras) and XXX were found in 0.15, 0.02 and 0.01% of the population, respectively, based solely on detection of abnormal segregation of a single X chromosome marker, LEX003. Detection at an early age and understanding of the prevalence of sex chromosome aberrations should assist in the diagnosis and managment of horses kept for breeding. Further, the parental origin of the X chromosome of each disorder could be proved by the results of genetic analysis, thereby contributing to cytogenetic characterisation.

Heat capacity and monogamy relations in the mixed-three-spin XXX Heisenberg model at low temperatures

NASA Astrophysics Data System (ADS)

Zad, Hamid Arian; Movahhedian, Hossein

2016-08-01

Heat capacity of a mixed-three-spin (1/2,1,1/2) antiferromagnetic XXX Heisenberg chain is precisely investigated by use of the partition function of the system for which, spins (1,1/2) have coupling constant J1 and spins (1/2,1/2) have coupling constant J2. We verify tripartite entanglement for the model by means of the convex roof extended negativity (CREN) and concurrence as functions of temperature T, homogeneous magnetic field B and the coupling constants J1 and J2. As shown in our previous work, [H. A. Zad, Chin. Phys. B 25 (2016) 030303.] the temperature, the magnetic field and the coupling constants dependences of the heat capacity for such spin system have different behaviors for the entangled and separable states, hence, we did some useful comparisons between this quantity and negativities of its organized bipartite (sub)systems at entangled and separable states. Here, we compare the heat capacity of the mixed-three-spin (1/2,1,1/2) system with the CREN and the tripartite concurrence (as measures of the tripartite entanglement) at low temperature. Ground state phase transitions, and also, transition from ground state to some excited states are explained in detail for this system at zero temperature. Finally, we investigate the heat capacity behavior around those critical points in which these quantum phase transitions occur.

The open XXX spin chain in the SoV framework: scalar product of separate states

NASA Astrophysics Data System (ADS)

Kitanine, N.; Maillet, J. M.; Niccoli, G.; Terras, V.

2017-06-01

We consider the XXX open spin-1/2 chain with the most general non-diagonal boundary terms, that we solve by means of the quantum separation of variables (SoV) approach. We compute the scalar products of separate states, a class of states which notably contains all the eigenstates of the model. As usual for models solved by SoV, these scalar products can be expressed as some determinants with a non-trivial dependance in terms of the inhomogeneity parameters that have to be introduced for the method to be applicable. We show that these determinants can be transformed into alternative ones in which the homogeneous limit can easily be taken. These new representations can be considered as generalizations of the well-known determinant representation for the scalar products of the Bethe states of the periodic chain. In the particular case where a constraint is applied on the boundary parameters, such that the transfer matrix spectrum and eigenstates can be characterized in terms of polynomial solutions of a usual T-Q equation, the scalar product that we compute here corresponds to the scalar product between two off-shell Bethe-type states. If in addition one of the states is an eigenstate, the determinant representation can be simplified, hence leading in this boundary case to direct analogues of algebraic Bethe ansatz determinant representations of the scalar products for the periodic chain.

Recombinant chromosome 7 in a mosaic 45,X/47,XXX patient.

PubMed

Tirado, Carlos A; Gotway, Garrett; Torgbe, Emmanuel; Iyer, Santha; Dallaire, Stephanie; Appleberry, Taylor; Suterwala, Mohamed; Garcia, Rolando; Valdez, Federico; Patel, Sangeeta; Koduru, Prasad

2012-01-01

Individuals with pericentric inversions are at risk for producing offspring with chromosomal gains and losses, while those carrying paracentric inversions usually produce unviable gametes [Madan, 1995]. In this current study, we present a newborn with dysmorphic features and malformations, whose karyotype showed an abnormal copy of chromomosome 7 described at first as add(7)(q32) as well as mos 45,X/47,XXX. Array comparative genomic hybridization (CGH) revealed an interstitial deletion in the long arm of chromosome 7 involving bands q35 to q36.3 but retaining the 7q subtelomere. The patient's deletion is believed to be due to meiotic recombination in the inversion loop in the phenotypically normal father who seems to carry two paracentric inversions in the long arm of chromosome 7, which was described as rec(7)(7pter- > q35::q36.3- > 7qter)pat. The abnormal copy of chromosome 7 in the father has been described as: der(7)(7pter- > q22.1::q36.3- > q35::q22.1- > q35::q36.3- > 7qter). This is a unique karyotype that to our knowledge has not been previously reported in the literature and predisposes to meiotic recombination that can result in deletions or duplications of 7q35-36. Copyright © 2011 Wiley Periodicals, Inc.

Energy levels, radiative rates and electron impact excitation rates for transitions in He-like Ga XXX, Ge XXXI, As XXXII, Se XXXIII and Br XXXIV

NASA Astrophysics Data System (ADS)

Aggarwal, Kanti M.; Keenan, Francis P.

2013-04-01

We report calculations of energy levels, radiative rates and electron impact excitation cross sections and rates for transitions in He-like Ga XXX, Ge XXXI, As XXXII, Se XXXIII and Br XXXIV. The grasp (general-purpose relativistic atomic structure package) is adopted for calculating energy levels and radiative rates. For determining the collision strengths, and subsequently the excitation rates, the Dirac atomic R-matrix code (darc) is used. Oscillator strengths, radiative rates and line strengths are reported for all E1, E2, M1 and M2 transitions among the lowest 49 levels of each ion. Additionally, theoretical lifetimes are provided for all 49 levels of the above five ions. Collision strengths are averaged over a Maxwellian velocity distribution and the effective collision strengths obtained listed over a wide temperature range up to 108 K. Comparisons are made with similar data obtained using the flexible atomic code (fac) to highlight the importance of resonances, included in calculations with darc, in the determination of effective collision strengths. Discrepancies between the collision strengths from darc and fac, particularly for some forbidden transitions, are also discussed. Finally, discrepancies between the present results for effective collision strengths with the darc code and earlier semi-relativistic R-matrix data are noted over a wide range of electron temperatures for many transitions in all ions.

Features of the broader autism phenotype in people with epilepsy support shared mechanisms between epilepsy and autism spectrum disorder.

PubMed

Richard, Annie E; Scheffer, Ingrid E; Wilson, Sarah J

2017-04-01

Richard, A.E., I.E. Scheffer and S.J. Wilson. Features of the broader autism phenotype in people with epilepsy support shared mechanisms between epilepsy and autism spectrum disorder. NEUROSCI BIOBEHAV REV 21(1) XXX-XXX, 2016. To inform on mechanisms underlying the comorbidity of epilepsy and autism spectrum disorder (ASD), we conducted meta-analyses to test whether impaired facial emotion recognition (FER) and theory of mind (ToM), key phenotypic traits of ASD, are more common in people with epilepsy (PWE) than controls. We contrasted these findings with those of relatives of individuals with ASD (ASD-relatives) compared to controls. Furthermore, we examined the relationship of demographic (age, IQ, sex) and epilepsy-related factors (epilepsy onset age, duration, seizure laterality and origin) to FER and ToM. Thirty-one eligible studies of PWE (including 1449 individuals: 77% with temporal lobe epilepsy), and 22 of ASD-relatives (N=1295) were identified by a systematic database search. Analyses revealed reduced FER and ToM in PWE compared to controls (p<0.001), but only reduced ToM in ASD-relatives (p<0.001). ToM was poorer in PWE than ASD-relatives. Only weak associations were found between FER and ToM and epilepsy-related factors. These findings suggest shared mechanisms between epilepsy and ASD, independent of intellectual disability. Copyright © 2017 Elsevier Ltd. All rights reserved.

Investigation of Fatigue Crack-Growth Resistance of Aluminum Alloys under Spectrum Loading.

DTIC Science & Technology

1983-04-01

Effects on Fatigue Crack Progation in 2024 -T3 Aluminum Alloy ," Eng. Frac. Mech, Vol...results ("a" from 6 to 13 mm) can be made (Figure 20a): 1. The 2XXX alloys 2020-T651, 2324-T39, and 2024 - T351 had longer spectrum fatigue lives than the...strength and spectrum life exists at all three maximum peak stress levels for the 2024 alloy , with the lower yield strength T351 condition having

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berenstein, David; Kavli Institute for Theoretical Physics, University of California at Santa Barbara, California 93106; Correa, Diego H.

We study an XXX open spin chain with variable number of sites, where the variability is introduced only at the boundaries. This model arises naturally in the study of giant gravitons in the anti-de Sitter-space/conformal field-theory correspondence. We show how to quantize the spin chain by mapping its states to a bosonic lattice of finite length with sources and sinks of particles at the boundaries. Using coherent states, we show how the Hamiltonian for the bosonic lattice gives the correct description of semiclassical open strings ending on giant gravitons.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cirilo Antonio, N.; Manojlovic, N.; Departamento de Matematica, FCT, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro

sl{sub 2} Gaudin model with jordanian twist is studied. This system can be obtained as the semiclassical limit of the XXX spin chain deformed by the jordanian twist. The appropriate creation operators that yield the Bethe states of the Gaudin model and consequently its spectrum are defined. Their commutation relations with the generators of the corresponding loop algebra as well as with the generating function of integrals of motion are given. The inner products and norms of Bethe states and the relation to the solutions of the Knizhnik-Zamolodchikov equations are discussed.

Undetected sex chromosome aneuploidy by chromosomal microarray.

PubMed

Markus-Bustani, Keren; Yaron, Yuval; Goldstein, Myriam; Orr-Urtreger, Avi; Ben-Shachar, Shay

2012-11-01

We report on a case of a female fetus found to be mosaic for Turner syndrome (45,X) and trisomy X (47,XXX). Chromosomal microarray analysis (CMA) failed to detect the aneuploidy because of a normal average dosage of the X chromosome. This case represents an unusual instance in which CMA may not detect chromosomal aberrations. Such a possibility should be taken into consideration in similar cases where CMA is used in a clinical setting. © 2012 John Wiley & Sons, Ltd.

Observations of Near-Bottom Flow in a Wave-Dominated Nearshore Environment.

DTIC Science & Technology

1994-02-01

E 0 0 0 ~- X : (- 1.. pI m~ ffm ~o .pcr onf> ..... X • -- E X/• x,. "£ "*.. . .. . 0o 0 0 a c c ,(s0wO) (S/PH w) (SlUwo) . 7109 I 3 I Mean of LDV...1 I 8250 ASM X,ANDA #&HBF :REM 0000 OXXX ACCA 8260 ASM X,ANDB #&HBF :REM 0000 1XXX ACCB 8270 ASM X,STAB &H17 :REM /CS=0 3 8280 ASM X,STAA &H17 :REM

Frustrated honeycomb-lattice bilayer quantum antiferromagnet in a magnetic field

NASA Astrophysics Data System (ADS)

Krokhmalskii, Taras; Baliha, Vasyl; Derzhko, Oleg; Schulenburg, Jörg; Richter, Johannes

2018-05-01

Frustrated bilayer quantum magnets have attracted attention as flat-band spin systems with unconventional thermodynamic properties. We study the low-temperature properties of a frustrated honeycomb-lattice bilayer spin-1/2 isotropic (XXX) Heisenberg antiferromagnet in a magnetic field by means of an effective low-energy theory using exact diagonalizations and quantum Monte Carlo simulations. Our main focus is on the magnetization curve and the temperature dependence of the specific heat indicating a finite-temperature phase transition in high magnetic fields.

Existence of ``free will'' as a problem of physics

NASA Astrophysics Data System (ADS)

Peres, Asher

1986-06-01

The proof of Bell's inequality is based on the assumption that distant observers can freely and independently choose their experiments. As Bell's inequality is experimentally violated, it appears that distant physical systems may behave as a single, nonlocal, indivisible entity. This apparent contradiction is resolved. It is shown that the “free will” assumption is, under usual circumstances, an excellent approximation. I have set before you life and death, blessing and cursing: therefore choose life.... — Deuteronomy XXX, 19

Weak Solution Classes for Parabolic Integro-Differential Equations

DTIC Science & Technology

1982-09-01

different existence argument for solutions of (I). It is partly based on a method that was used in (2) and (6] to treat a Hilbert - space version of (I) and...xx Differential Equations 35 (1980), 200-231. 121 V. Barbut Integro-Oifferential Squatton. in Hilbert Spaces. Ann. St. Univ. *Al. 1. Cuaxa 19 (1973... Greenberg : O,% the Existence, Uniqueness, and stability of the Equation 00 Xtt - 3(XX)X) AX *x . J Math. Anal. Appl. 25 (1969), S75-591. (131 7

Defense Energy Information System (DEIS): DEIS-80 Design System Specification. Revision B,

DTIC Science & Technology

1982-07-01

are samples of the queries that may be requested. - Display the data for DoDAAC = XXYMOX, Date = MMYY, Product Code = XXX. - What is the total...consumption in gallons. What is the percent change in total consumption (or average daily consumption) for Major Command = X---X, between this month and this...month a year ago (or this quarter and the previous 5 quarters) for distillates (or fuel oil)? What is the total consumption for each Service for the

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qasim, Mohammad A., E-mail: qasimm@ipfw.edu; Song, Jikui; Markley, John L.

Research highlights: {yields} Large pK shifts in ionizable groups when buried in the protein interior. {yields} Substrate dependent shifts in pH optimum for serine proteases. {yields} Lys side chain is a stronger acid in serine protease S{sub 1} pocket than Asp side chain. -- Abstract: Enzymatic hydrolysis of the synthetic substrate succinyl-Ala-Ala-Pro-Xxx-pNA (where Xxx = Leu, Asp or Lys) catalyzed by bovine chymotrypsin (CHYM) or Streptomyces griseus protease B (SGPB) has been studied at different pH values in the pH range 3-11. The pH optima for substrates having Leu, Asp, and Lys have been found to be 7.5-8.0, 5.5-6.0, andmore » {approx}10, respectively. At the normally reported pH optimum (pH 7-8) of CHYM and SGPB, the substrate with Leu at the reactive site is more than 25,000-fold more reactive than that with Asp. However, when fully protonated, Asp is nearly as good a substrate as Leu. The pK values of the side chains of Asp and Lys in the hydrophobic S{sub 1} pocket of CHYM and SGPB have been calculated from pH-dependent hydrolysis data and have been found to be about 9 for Asp and 7.4 and 9.7 for Lys for CHYM and SGPB, respectively. The results presented in this communication suggest a possible application of CHYM like enzymes in cleaving peptide bonds contributed by acidic amino acids between pH 5 and 6.« less

Genetics of dioecy and causal sex chromosomes in plants.

PubMed

Kumar, Sushil; Kumari, Renu; Sharma, Vishakha

2014-04-01

Dioecy (separate male and female individuals) ensures outcrossing and is more prevalent in animals than in plants. Although it is common in bryophytes and gymnosperms, only 5% of angiosperms are dioecious. In dioecious higher plants, flowers borne on male and female individuals are, respectively deficient in functional gynoecium and androecium. Dioecy is inherited via three sex chromosome systems: XX/XY, XX/X0 and WZ/ZZ, such that XX or WZ is female and XY, X0 or ZZ are males. The XX/XY system generates the rarer XX/X0 and WZ/ZZ systems. An autosome pair begets XY chromosomes. A recessive loss-of-androecium mutation (ana) creates X chromosome and a dominant gynoecium-suppressing (GYS) mutation creates Y chromosome. The ana/ANA and gys/GYS loci are in the sex-determining region (SDR) of the XY pair. Accumulation of inversions, deleterious mutations and repeat elements, especially transposons, in the SDR of Y suppresses recombination between X and Y in SDR, making Y labile and increasingly degenerate and heteromorphic from X. Continued recombination between X and Y in their pseudoautosomal region located at the ends of chromosomal arms allows survival of the degenerated Y and of the species. Dioecy is presumably a component of the evolutionary cycle for the origin of new species. Inbred hermaphrodite species assume dioecy. Later they suffer degenerate-Y-led population regression. Cross-hybridization between such extinguishing species and heterologous species, followed by genome duplication of segregants from hybrids, give rise to new species.

Serum FSH level below 10 mIU/mL at twelve years old is an index of spontaneous and cyclical menstruation in Turner syndrome.

PubMed

Aso, Keiko; Koto, Shinobu; Higuchi, Asako; Ariyasu, Daisuke; Izawa, Masako; Miyamoto Igaki, Junko; Hasegawa, Yukihiro

2010-01-01

The gonadal function of patients with Turner syndrome (TS) is variable. Individuals with mosaicism characterized by 45,X/46,XX or 45,X/47,XXX are more likely to experience spontaneous menarche compared with other karyotypes. Prepubertal gonadotropins of TS patients with spontaneous menarche are reportedly normal or significantly lower than those of patients with induced menarche. The present study investigated an index of spontaneous and cyclical menstruation at 10-12 years old in TS. Subjects comprised 50 patients with TS, divided into three groups: Group A (n=7), with spontaneous menarche before 16 years old and regular menstruation for at least 1 year and 6 months; Group B (n=6), with irregular menstruation since menarche leading to secondary amenorrhea despite spontaneous menarche before 16 years old; and Group C (n=37), without spontaneous breast budding before 14 years old or without spontaneous menarche before 16 years old. Karyotype, LH and FSH concentrations at 10 and 12 years old were analyzed retrospectively. Spontaneous and cyclical menstruation was more frequently observed in TS with mosaicism characterized by 45,X/46,XX or 45,X/47,XXX than in TS with other karyotypes, as previously described. Spontaneous and cyclical menstruation in TS was observed when serum FSH level was <10 mIU/mL at 12 years old, suggesting this FSH level as an index of spontaneous and cyclical menstruation in TS.

Neurocognitive effects of methylphenidate in adults with attention-deficit/hyperactivity disorder: A meta-analysis.

PubMed

Pievsky, Michelle A; McGrath, Robert E

2018-05-08

PIEVSKY, M. A., and R. E. McGrath. Neurocognitive effects of methylphenidate in adults with attention-deficit/hyperactivity disorder: A meta-analysis…NEUROSCI BIOBEHAV REV 81(1) XXX-XXX, 2017.- This meta-analysis summarized 21 double-blind randomized controlled trials with a mean study duration of 18 days comparing the neurocognitive functioning of adults with attention-deficit/hyperactivity disorder (ADHD) on methylphenidate vs placebo. Effect sizes were weighted using a random-effects model. Scores on neurocognitive measures and tests of driving ability were on average higher on methylphenidate than on placebo, g = 0.17, p < .01, 95% CI = [0.05, 0.28], with little heterogeneity, Q(20) = 15.05, p = .77, I 2  = 0. Performance on methylphenidate was significantly better than on placebo for the following domains: working memory (mean g = 0.13, 95% CI = [0.00, 0.26]), reaction time variability (0.16, [0.03, 0.28]), vigilance (0.22, [0.11, 0.33]), driving (0.22, [0.10, 0.34]), and response inhibition (0.23, [0.10, 0.36]). Quantitative and qualitative assessment revealed evidence of publication bias. Summarizing across studies, methylphenidate improved the performance of adults with ADHD on neurocognitive measures and tests of driving, suggesting that methylphenidate is an effective treatment for adults with ADHD and can improve processes related to attention and concentration. Copyright © 2018 Elsevier Ltd. All rights reserved.

Triple X syndrome: a review of the literature.

PubMed

Otter, Maarten; Schrander-Stumpel, Constance T R M; Curfs, Leopold M G

2010-03-01

The developmental and clinical aspects in the literature on triple X syndrome are reviewed. Prenatal diagnosis depends on karyotyping. The incidence is 1 of 1000 females. At birth, 47,XXX girls have a lower mean birth weight and a smaller head circumference. Triple X diagnosis was not suspected at birth. The maternal age seems to be increased. Toddlers with triple X syndrome show delayed language development. The youngest girls show accelerated growth until puberty. EEG abnormalities seem to be rather common. Many girls show motor-coordination problems and auditory-processing disorders are not rare. Scoliosis is probably more common in adolescent cases. The IQ levels are 20 points below that of controls, and verbal IQ is lowest. The girls struggle with low self-esteem and they need psychological, behavioural and educational support. They perform best in stable families. After leaving school they seem to feel better. In adults, premature ovarian failure seems to be more prevalent than in controls. MRIs of the brain seem to show decreased brain volumes. The 47,XXX women most often find jobs that reflect their performance abilities. Psychotic illness seems to be more prevalent in triple X adult women than in controls. Psychotic disorders respond well to psychotropic drugs. Triple X adults suffer more frequently from cyclothymic and labile personality traits. Research on triple X syndrome may yield more insight into brain and behaviour relations, developmental psychopathology, auditory-processing disorders, EEG disorders, personality and psychotic disorders, etc.

Lack of Microbial Diversity in an Extreme Mars Analog Setting: Poás Volcano, Costa Rica.

PubMed

Hynek, Brian M; Rogers, Karyn L; Antunovich, Monique; Avard, Geoffroy; Alvarado, Guillermo E

2018-04-24

The Poás volcano in Costa Rica has been studied as a Mars geochemical analog environment, since both the style of hydrothermal alteration present and the alteration mineralogy are consistent with Mars' relict hydrothermal systems. The site hosts an active volcano, with high-temperature fumaroles (up to 980°C) and an ultra-acidic lake. This lake, Laguna Caliente, is one of the most dynamic environments on Earth, with frequent phreatic eruptions, temperatures ranging from near-ambient to almost boiling, a pH range of -1 to 1.5, and a wide range of chemistries and redox potential. Martian acid-sulfate hydrothermal systems were likely similarly dynamic and equally challenging to life. The microbiology existing within Laguna Caliente was characterized for the first time, with sampling taking place in November, 2013. The diversity of the microbial community was surveyed via extraction of environmental DNA from fluid and sediment samples followed by Illumina sequencing of the 16S rRNA gene. The microbial diversity was limited to a single species of the bacterial genus Acidiphilium. This organism likely gets its energy from oxidation of reduced sulfur in the lake, including elemental sulfur. Given Mars' propensity for sulfur and acid-sulfate environments, this type of organism is of significant interest to the search for past or present life on the Red Planet. Key Words: Mars astrobiology-Acid-sulfate hydrothermal systems-Extremophiles-Acidic-High temperature-Acidiphilium bacteria. Astrobiology 18, xxx-xxx.

A case-control study of brain structure and behavioral characteristics in 47,XXX Syndrome

PubMed Central

Lenroot, Rhoshel K.; Blumenthal, Jonathan D.; Wallace, Gregory L.; Clasen, Liv S.; Lee, Nancy Raitano; Giedd, Jay N.

2014-01-01

Trisomy X, the presence of an extra X chromosome in females (47,XXX), is a relatively common but under-recognized chromosomal disorder associated with characteristic cognitive and behavioral features of varying severity. The objective of this study was to determine whether there were neuroanatomical differences in girls with Trisomy X that could relate to cognitive and behavioral differences characteristic of the disorder during childhood and adolescence. MRI scans were obtained on 35 girls with Trisomy X (mean age 11.4, s.d. 5.5) and 70 age- and sex- matched healthy controls. Cognitive and behavioral testing was also performed. Trisomy X girls underwent a semi-structured psychiatric interview. Regional brain volumes and cortical thickness were compared between the two groups. Total brain volume was significantly decreased in subjects with Trisomy X, as were all regional volumes with the exception of parietal gray matter. Differences in cortical thickness had a mixed pattern. The subjects with Trisomy X had thicker cortex in bilateral medial prefrontal cortex and right medial temporal lobe, but decreased cortical thickness in both lateral temporal lobes. The most common psychiatric disorders present in this sample of Trisomy X girls included anxiety disorders, (40%), Attention-Deficit Disorder (17%), and depressive disorders (11%). The most strongly affected brain regions are consistent with phenotypic characteristics such as language delay, poor executive function, and heightened anxiety previously described in population-based studies of Trisomy X and also found in our sample. PMID:25287572

C. elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity

PubMed Central

Zhang, Yanmei; Xu, Jinling; Puscau, Cristina; Kim, Yongsoon; Wang, Xi; Alam, Hena; Hu, Patrick J.

2008-01-01

SUMMARY Insulin regulates development, metabolism, and lifespan via a conserved PI3K/Akt pathway that promotes cytoplasmic sequestration of FoxO transcription factors. The regulation of nuclear FoxO is poorly understood. In the nematode Caenorhabditis elegans, insulin-like signaling functions in larvae to inhibit dauer arrest and acts during adulthood to regulate lifespan. In a screen for genes that modulate C. elegans insulin-like signaling, we identified eak-3, which encodes a novel protein that is specifically expressed in the two endocrine XXX cells. The dauer arrest phenotype of eak-3 mutants is fully suppressed by mutations in daf-16/FoxO, which encodes the major target of C. elegans insulin-like signaling, and daf-12, which encodes a nuclear receptor regulated by steroid hormones known as dafachronic acids. eak-3 mutation does not affect DAF-16/FoxO subcellular localization but enhances expression of the direct DAF-16/FoxO target sod-3 in a daf-16/FoxO- and daf-12-dependent manner. eak-3 mutants have normal lifespans, suggesting that EAK-3 decouples insulin-like regulation of development and longevity. We propose that EAK-3 activity in the XXX cells promotes the synthesis and/or secretion of a hormone that acts in parallel to AKT-1 to inhibit the expression of DAF-16/FoxO target genes. Similar hormonal pathways may regulate FoxO target gene expression in mammals. PMID:18241854

Exoplanet Biosignatures: A Framework for Their Assessment.

PubMed

Catling, David C; Krissansen-Totton, Joshua; Kiang, Nancy Y; Crisp, David; Robinson, Tyler D; DasSarma, Shiladitya; Rushby, Andrew J; Del Genio, Anthony; Bains, William; Domagal-Goldman, Shawn

2018-04-20

Finding life on exoplanets from telescopic observations is an ultimate goal of exoplanet science. Life produces gases and other substances, such as pigments, which can have distinct spectral or photometric signatures. Whether or not life is found with future data must be expressed with probabilities, requiring a framework of biosignature assessment. We present a framework in which we advocate using biogeochemical "Exo-Earth System" models to simulate potential biosignatures in spectra or photometry. Given actual observations, simulations are used to find the Bayesian likelihoods of those data occurring for scenarios with and without life. The latter includes "false positives" wherein abiotic sources mimic biosignatures. Prior knowledge of factors influencing planetary inhabitation, including previous observations, is combined with the likelihoods to give the Bayesian posterior probability of life existing on a given exoplanet. Four components of observation and analysis are necessary. (1) Characterization of stellar (e.g., age and spectrum) and exoplanetary system properties, including "external" exoplanet parameters (e.g., mass and radius), to determine an exoplanet's suitability for life. (2) Characterization of "internal" exoplanet parameters (e.g., climate) to evaluate habitability. (3) Assessment of potential biosignatures within the environmental context (components 1-2), including corroborating evidence. (4) Exclusion of false positives. We propose that resulting posterior Bayesian probabilities of life's existence map to five confidence levels, ranging from "very likely" (90-100%) to "very unlikely" (<10%) inhabited. Key Words: Bayesian statistics-Biosignatures-Drake equation-Exoplanets-Habitability-Planetary science. Astrobiology 18, xxx-xxx.

Entropic uncertainty for spin-1/2 XXX chains in the presence of inhomogeneous magnetic fields and its steering via weak measurement reversals

NASA Astrophysics Data System (ADS)

Wang, Dong; Ming, Fei; Huang, Ai-Jun; Sun, Wen-Yang; Ye, Liu

2017-09-01

The uncertainty principle configures a low bound to the measuring precision for a pair of non-commuting observables, and hence is considerably nontrivial to quantum precision measurement in the field of quantum information theory. In this letter, we consider the entropic uncertainty relation (EUR) in the context of quantum memory in a two-qubit isotropic Heisenberg spin chain. Specifically, we explore the dynamics of EUR in a practical scenario, where two associated nodes of a one-dimensional XXX-spin chain, under an inhomogeneous magnetic field, are connected to a thermal entanglement. We show that the temperature and magnetic field effect can lead to the inflation of the measuring uncertainty, stemming from the reduction of systematic quantum correlation. Notably, we reveal that, firstly, the uncertainty is not fully dependent on the observed quantum correlation of the system; secondly, the dynamical behaviors of the measuring uncertainty are relatively distinct with respect to ferromagnetism and antiferromagnetism chains. Meanwhile, we deduce that the measuring uncertainty is dramatically correlated with the mixedness of the system, implying that smaller mixedness tends to reduce the uncertainty. Furthermore, we propose an effective strategy to control the uncertainty of interest by means of quantum weak measurement reversal. Therefore, our work may shed light on the dynamics of the measuring uncertainty in the Heisenberg spin chain, and thus be important to quantum precision measurement in various solid-state systems.

Microstructural evolution during the homogenization heat treatment of 6XXX and 7XXX aluminum alloys

NASA Astrophysics Data System (ADS)

Priya, Pikee

Homogenization heat treatment of as-cast billets is an important step in the processing of aluminum extrusions. Microstructural evolution during homogenization involves elimination of the eutectic morphology by spheroidisation of the interdendritic phases, minimization of the microsegregation across the grains through diffusion, dissolution of the low-melting phases, which enhances the surface finish of the extrusions, and precipitation of nano-sized dispersoids (for Cr-, Zr-, Mn-, Sc-containing alloys), which inhibit grain boundary motion to prevent recrystallization. Post-homogenization cooling reprecipitates some of the phases, changing the flow stress required for subsequent extrusion. These precipitates, however, are deleterious for the mechanical properties of the alloy and also hamper the age-hardenability and are hence dissolved during solution heat treatment. Microstructural development during homogenization and subsequent cooling occurs both at the length scale of the Secondary Dendrite Arm Spacing (SDAS) in micrometers and dispersoids in nanometers. Numerical tools to simulate microstructural development at both the length scales have been developed and validated against experiments. These tools provide easy and convenient means to study the process. A Cellular Automaton-Finite Volume-based model for evolution of interdendritic phases is coupled with a Particle Size Distribution-based model for precipitation of dispersoids across the grain. This comprehensive model has been used to study the effect of temperature, composition, as-cast microstructure, and cooling rates during post-homogenization quenching on microstructural evolution. The numerical study has been complimented with experiments involving Scanning Electron Microscopy, Energy Dispersive Spectroscopy, X-Ray Diffraction and Differential Scanning Calorimetry and a good agreement has with numerical results has been found. The current work aims to study the microstructural evolution during homogenization heat treatment at both length scales which include the (i) dissolution and transformation of the as-cast secondary phases; (ii) precipitation of dispersoids; and (iii) reprecipitation of some of the secondary phases during post-homogenization cooling. The kinetics of the phase transformations are mostly diffusion controlled except for the eta to S phase transformation in 7XXX alloys which is interface reaction rate controlled which has been implemented using a novel approach. Recommendations for homogenization temperature, time, cooling rates and compositions are made for Al-Si-Mg-Fe-Mn and Al-Zn-Cu-Mg-Zr alloys. The numerical model developed has been applied for a through process solidification-homogenization modeling of a Direct-Chill cast AA7050 cylindrical billet to study the radial variation of microstructure after solidification, homogenization and post-homogenization cooling.

Misleading Advertising by Attorneys Concerning NOACs is Adversely Costly to Our Patients and Our Society.

PubMed

James, A; Reiffel, M

2016-01-01

Over the past five years, "ambulance-chasing" attorneys have aggressively advertised for patients who have bled on a new oral anticoagulant (NOAC) or their family members. It is an infrequent day when American consumers do not see a TV advertisement saying something like: "Have you or a loved-one had a serious bleeding event while taking [fill in the NOAC]? If so, you may be entitled to monetary compensation. Call XXX, attorneys at law, and we will get you the money you deserve."

Evaluation of Noise Effects in Auditory Function in Spanish Military Pilots

DTIC Science & Technology

2005-04-01

traumatismo sonoro crónico. Su incidencia en el medio aéreo. 131 Curso de Aptitud para el Ascenso a Comandante. Escuela Superior del E.A. Madrid 1991...FAYALA M.: Détèrorations audiométriques chez le pilote militaire en Tunisie. Méd. Aéro. Spat., Tome XXX, Nº 119 - 1991. [13] LORENTE J.: El...14] LORENTE J.M.: “Cambios auditivos en los pilotos de las Fuerzas Armadas. Revisión bibliográfica.” Revista Universitaria de Sanidad. Vol. 1, Núm. 1

Selected DOE headquarters publications

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1979-07-01

Selected DOE Headquarters Publications provides cumulative listings, from October 1, 1977 onward, of two groups of publications issued by headquarters organizations of the Department of Energy, and an index to their title keywords. The two groups consist of publications assigned a DOE/XXX-type report number code and headquarters contractor publications, prepared by contractors (and published by DOE) to describe research and development work they have performed for the Department. Publications such as pamphlets, fact sheets, bulletins, newsletters, and telephone directories, are omitted, as are publications issued under the DOE-tr, CONF, DOE/JPL, and DOE/NASA codes. (RWR)

The Topological Basis Realization for Six Qubits and the Corresponding Heisenberg Spin -{1/2} Chain Model

NASA Astrophysics Data System (ADS)

Yang, Qi; Cao, Yue; Chen, Shiyin; Teng, Yue; Meng, Yanli; Wang, Gangcheng; Sun, Chunfang; Xue, Kang

2018-03-01

In this paper, we construct a new set of orthonormal topological basis states for six qubits with the topological single loop d = 2. By acting on the subspace, we get a new five-dimensional (5D) reduced matrix. In addition, it is shown that the Heisenberg XXX spin-1/2 chain of six qubits can be constructed from the Temperley-Lieb algebra (TLA) generator, both the energy ground state and the spin singlet states of the system can be described by the set of topological basis states.

Mechanical joining of materials with limited ductility: Analysis of process-induced defects

NASA Astrophysics Data System (ADS)

Jäckel, M.; Coppieters, S.; Hofmann, M.; Vandermeiren, N.; Landgrebe, D.; Debruyne, D.; Wallmersberger, T.; Faes, K.

2017-10-01

The paper shows experimental and numerical analyses of the clinching process of 6xxx series aluminum sheets in T6 condition and the self-pierce riveting process of an aluminum die casting. In the experimental investigations the damage behavior of the materials when using different tool parameters is analyzed. The focus of the numerical investigations is the damage prediction by a comparison of different damage criteria. Moreover, strength-and fatigue tests were carried out to investigate the influence of the joining process-induced damages on the strength properties of the joints.

Expanding the Bethe/Gauge dictionary

NASA Astrophysics Data System (ADS)

Bullimore, Mathew; Kim, Hee-Cheol; Lukowski, Tomasz

2017-11-01

We expand the Bethe/Gauge dictionary between the XXX Heisenberg spin chain and 2d N = (2, 2) supersymmetric gauge theories to include aspects of the algebraic Bethe ansatz. We construct the wave functions of off-shell Bethe states as orbifold defects in the A-twisted supersymmetric gauge theory and study their correlation functions. We also present an alternative description of off-shell Bethe states as boundary conditions in an effective N = 4 supersymmetric quantum mechanics. Finally, we interpret spin chain R-matrices as correlation functions of Janus interfaces for mass parameters in the supersymmetric quantum mechanics.

Retrieve the Bethe states of quantum integrable models solved via the off-diagonal Bethe Ansatz

NASA Astrophysics Data System (ADS)

Zhang, Xin; Li, Yuan-Yuan; Cao, Junpeng; Yang, Wen-Li; Shi, Kangjie; Wang, Yupeng

2015-05-01

Based on the inhomogeneous T-Q relation constructed via the off-diagonal Bethe Ansatz, a systematic method for retrieving the Bethe-type eigenstates of integrable models without obvious reference state is developed by employing certain orthogonal basis of the Hilbert space. With the XXZ spin torus model and the open XXX spin- \\frac{1}{2} chain as examples, we show that for a given inhomogeneous T-Q relation and the associated Bethe Ansatz equations, the constructed Bethe-type eigenstate has a well-defined homogeneous limit.

Q-operators for the open Heisenberg spin chain

NASA Astrophysics Data System (ADS)

Frassek, Rouven; Szécsényi, István M.

2015-12-01

We construct Q-operators for the open spin-1/2 XXX Heisenberg spin chain with diagonal boundary matrices. The Q-operators are defined as traces over an infinite-dimensional auxiliary space involving novel types of reflection operators derived from the boundary Yang-Baxter equation. We argue that the Q-operators defined in this way are polynomials in the spectral parameter and show that they commute with transfer matrix. Finally, we prove that the Q-operators satisfy Baxter's TQ-equation and derive the explicit form of their eigenvalues in terms of the Bethe roots.

The Topological Basis Realization for Six Qubits and the Corresponding Heisenberg Spin-1/2 Chain Model

NASA Astrophysics Data System (ADS)

Yang, Qi; Cao, Yue; Chen, Shiyin; Teng, Yue; Meng, Yanli; Wang, Gangcheng; Sun, Chunfang; Xue, Kang

2018-06-01

In this paper, we construct a new set of orthonormal topological basis states for six qubits with the topological single loop d = 2. By acting on the subspace, we get a new five-dimensional (5 D) reduced matrix. In addition, it is shown that the Heisenberg XXX spin-1/2 chain of six qubits can be constructed from the Temperley-Lieb algebra (TLA) generator, both the energy ground state and the spin singlet states of the system can be described by the set of topological basis states.

Refined counting of necklaces in one-loop N=4 SYM

NASA Astrophysics Data System (ADS)

Suzuki, Ryo

2017-06-01

We compute the grand partition function of N=4 SYM at one-loop in the SU(2) sector with general chemical potentials, extending the results of Pólya's theorem. We make use of finite group theory, applicable to all orders of perturbative 1 /N c expansion. We show that only the planar terms contribute to the grand partition function, which is therefore equal to the grand partition function of an ensemble of {XXX}_{1/2} spin chains. We discuss how Hagedorn temperature changes on the complex plane of chemical potentials.

Welding procedure specification. Suppliment 1. Records of procedure qualification tests. Gas tungsten arc welding of aluminum alloys 1XXX and 3003 to 3004, 5052 and 5X54. [1060, 1100, and 3003 to 3004, 5052, 5154, and 5454

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wodtke, C.H.; Frizzell, D.R.; Plunkett, W.A.

1986-06-01

Procedure WPS-2202 is qualified under Section IX of the ASME Boiler and Pressure Vessel Code for gas tungsten arc welding of aluminum alloys 1060, 1100, and 3003 (P-21) to 3004, 5052, 5154, and 5454 (P-22), in thickness range 0.062 to 0.062 to 0.5 inch; filler metal is ER5356 (F-22); shielding gas is argon.

Some applications of the Kronecker product in Hubbard representation

NASA Astrophysics Data System (ADS)

Enríquez, Marco; Rosas-Ortiz, Oscar

2014-10-01

The properties of the Kronecker product are revisited in terms of Hubbard operators. The simplest representation of a Hubbard operator Xi,jn is a square matrix of size n with an entry equal to 1 and zero elsewhere. This framework simplifies the calculation of the Kronecker product of arbitrary matrices no matter the size or the number of the involved factors. Some applications are presented, these include the algebra of permutation matrices, the Hadamard matrix, the XXX Heisenberg model and the interaction of an atom with radiation fields.

Solutions of the Bethe ansatz equations for XXX antiferromagnet of arbitrary spin in the case of a finite number of sites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Avdeev, L.V.; Doerfel, B.D.

1987-11-01

The exactly integrable isotropic Heisenberg chain of N spins s is studied, and numerical solutions to the Bethe ansatz equations corresponding to the antiferromagnetic vacuum (for sN less than or equal to 128) and the simplest excitations have been obtained. For s = 1, a complete set of states for N = 6 is given, and the vacuum solution for finite N is estimated analytically. The deviations from the string picture at large N are discussed.

Creation operator for spinons in one dimension

DOE Office of Scientific and Technical Information (OSTI.GOV)

Talstra, J.C.; Strong, S.P.

1997-09-01

We propose a definition for a creation operator for the spinon, the fractional statistics elementary excitation of the Haldane-Shastry model, and give numerical and analytical evidence that our operator creates a single spinon with nearly unit amplitude in the Heisenberg model with inverse squared exchange. We then discuss how the operator is useful in more general contexts such as studying the underlying spinons of other spin-chain models, like the XXX and XY model, and of the one-dimensional Hubbard model. {copyright} {ital 1997} {ital The American Physical Society}

Stem Cell Therapy for Erectile Dysfunction.

PubMed

Matz, Ethan L; Terlecki, Ryan; Zhang, Yuanyuan; Jackson, John; Atala, Anthony

2018-04-06

The prevalence of erectile dysfunction (ED) is substantial and continues to rise. Current therapeutics for ED consist of oral medications, intracavernosal injections, vacuum erection devices, and penile implants. While such options may manage the disease state, none of these modalities, however, restore function. Stem cell therapy has been evaluated for erectile restoration in animal models. These cells have been derived from multiple tissues, have varied potential, and may function via local engraftment or paracrine signaling. Bone marrow-derived stem cells (BMSC) and adipose-derived stem cells (ASC) have both been used in these models with noteworthy effects. Herein, we will review the pathophysiology of ED, animal models, current and novel stem-cell based therapeutics, clinical trials and areas for future research. The relevant literature and contemporary data using keywords, "stem cells and erectile dysfunction" was reviewed. Examination of evidence supporting the association between erectile dysfunction and adipose derived stem cells, bone marrow derived stem cells, placental stem cells, urine stem cells and stem cell therapy respectively. Placental-derived stem cells and urine-derived stem cells possess many similar properties as BMSC and ASC, but the methods of acquisition are favorable. Human clinical trials have already demonstrated successful use of stem cells for improvement of erectile function. The future of stem cell research is constantly being evaluated, although, the evidence suggests a place for stem cells in erectile dysfunction therapeutics. Matz EL, Terlecki R, Zhang Y, et al. Stem Cell Therapy for Erectile Dysfunction. Sex Med Rev 2018;XX:XXX-XXX. Copyright © 2018 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.

Evaluation of the Tindouf Basin Region in Southern Morocco as an Analog Site for Soil Geochemistry on Noachian Mars.

PubMed

Oberlin, Elizabeth A; Claire, Mark W; Kounaves, Samuel P

2018-02-09

Locations on Earth that provide insights into processes that may be occurring or may have occurred throughout martian history are often broadly deemed "Mars analog environments." As no single locale can precisely represent a past or present martian environment, it is important to focus on characterization of terrestrial processes that produce analogous features to those observed in specific regions of Mars or, if possible, specific time periods during martian history. Here, we report on the preservation of ionic species in soil samples collected from the Tindouf region of Morocco and compare them with the McMurdo Dry Valleys of Antarctica, the Atacama Desert in Chile, the martian meteorite EETA79001, and the in situ Mars analyses from the Phoenix Wet Chemistry Laboratory (WCL). The Moroccan samples show the greatest similarity with those from Victoria Valley, Beacon Valley, and the Atacama, while being consistently depleted compared to University Valley and enriched compared to Taylor Valley. The NO 3 /Cl ratios are most similar to Victoria Valley and Atacama, while the SO 4 /Cl ratios are similar to those from Beacon Valley, Victoria Valley, and the Atacama. While perchlorate concentrations in the Moroccan samples are typically lower than those found in samples of other analog sites, conditions in the region are sufficiently arid to retain oxychlorines at detectable levels. Our results suggest that the Tindouf Basin in Morocco can serve as a suitable analogue for the soil geochemistry and subsequent aridification of the Noachian epoch on Mars. Key Words: Mars analogues-Antarctica-Morocco-Oxyanions-Perchlorate-Nitrate. Astrobiology 18, xxx-xxx.

Sulfidic Anion Concentrations on Early Earth for Surficial Origins-of-Life Chemistry.

PubMed

Ranjan, Sukrit; Todd, Zoe R; Sutherland, John D; Sasselov, Dimitar D

2018-04-08

A key challenge in origin-of-life studies is understanding the environmental conditions on early Earth under which abiogenesis occurred. While some constraints do exist (e.g., zircon evidence for surface liquid water), relatively few constraints exist on the abundances of trace chemical species, which are relevant to assessing the plausibility and guiding the development of postulated prebiotic chemical pathways which depend on these species. In this work, we combine literature photochemistry models with simple equilibrium chemistry calculations to place constraints on the plausible range of concentrations of sulfidic anions (HS - , HSO 3 - , SO 3 2- ) available in surficial aquatic reservoirs on early Earth due to outgassing of SO 2 and H 2 S and their dissolution into small shallow surface water reservoirs like lakes. We find that this mechanism could have supplied prebiotically relevant levels of SO 2 -derived anions, but not H 2 S-derived anions. Radiative transfer modeling suggests UV light would have remained abundant on the planet surface for all but the largest volcanic explosions. We apply our results to the case study of the proposed prebiotic reaction network of Patel et al. ( 2015 ) and discuss the implications for improving its prebiotic plausibility. In general, epochs of moderately high volcanism could have been especially conducive to cyanosulfidic prebiotic chemistry. Our work can be similarly applied to assess and improve the prebiotic plausibility of other postulated surficial prebiotic chemistries that are sensitive to sulfidic anions, and our methods adapted to study other atmospherically derived trace species. Key Words: Early Earth-Origin of life-Prebiotic chemistry-Volcanism-UV radiation-Planetary environments. Astrobiology 18, xxx-xxx.

Prospective study to determine early hypertrophy of the contra-lateral liver lobe after unilobar, Yttrium-90, selective internal radiation therapy in patients with hepatocellular carcinoma.

PubMed

Teo, Jin Yao; Allen, John Carson; Ng, David Chee Eng; Abdul Latiff, Julianah Bee; Choo, Su Pin; Tai, David Wai-Meng; Low, Albert Su Chong; Cheah, Foong Koon; Chang, Jason Pik Eu; Kam, Juinn Huar; Lee, Victor T W; Chung, Alexander Yaw Fui; Chan, Chung Yip; Chow, Pierce Kah Hoe; Goh, Brian K P

2018-05-01

Liver resection is a major curative option in patients presenting with hepatocellular carcinoma. An inadequate functional liver remnant is a major limiting factor precluding liver resection. In recent years, hypertrophy of the functional liver remnant after selective internal radiation therapy hypertrophy has been observed, but the degree of hypertrophy in the early postselective internal radiation therapy period has not been well studied. We conducted a prospective study on patients undergoing unilobar, Yttrium-90 selective internal radiation therapy for hepatocellular carcinoma to evaluate early hypertrophy at 4-6 weeks and 8-12 weeks after selective internal radiation therapy. In the study, 24 eligible patients were recruited and had serial volumetric measurements performed. The median age was 66 years (38-75 years). All patients were either Child-Pugh Class A or B, and 6/24 patients had documented, clinically relevant portal hypertension; 15 of the 24 patients were hepatitis B positive. At 4-6 weeks, modest hypertrophy was seen (median 3%; range -12 to 42%) and this increased at 8-12 weeks (median 9%; range -12 to 179%). No preprocedural factors predictive of hypertrophy were identified. Hypertrophy of the functional liver remnant after selective internal radiation therapy with Yttrium-90 occurred in a subset of patients but was modest and unpredictable in the early stages. Selective internal radiation therapy cannot be recommended as a standard treatment modality to induce early hypertrophy for patients with hepatocellular carcinoma. (Surgery 2017;160:XXX-XXX.). Copyright © 2017 Elsevier Inc. All rights reserved.

Microstructure Evolution and the Resulted Influence on Localized Corrosion in Al-Zn-Mg-Cu Alloy during Non-Isothermal Ageing

PubMed Central

Chen, Jun-Zhou; Li, Guo-Ai; Cai, Xin; Jiang, Jian-Tang; Shao, Wen-Zhu; Yang, Li; Zhen, Liang

2018-01-01

A non-isothermal ageing process was proposed for an Al-Zn-Mg-Cu alloy aiming to accommodate the slow heating/cooling procedure during the ageing of large components. The evolution of microstructure and microchemistry was analyzed by using transmission electron microscopy, high-angle annular dark field imaging, and energy dispersive spectrometry. The age-hardening of the alloy was examined to evaluate the strengthening behavior during the non-isothermal process. The corrosion behavior was investigated via observing the specimens immersed in EXCO solution (solution for Exfoliation Corrosion Susceptibility test in 2xxx and 7xxx series aluminum alloys, referring ASTM G34-01). Secondary precipitation was observed during the cooling stage, leading to increased precipitate number density. The distribution of grain boundary precipitates transits from discontinuous to continuous at the cooling stage, due to the secondary precipitation’s linking-up effect. The solutes’ enrichment on grain boundary precipitates and the depletion in precipitate-free zones develops during the heating procedure, but remains invariable during the cooling procedure. The corrosion in NIA (Non-isothermal Ageing) treated specimens initiates from pitting and then transits to intergranular corrosion and exfoliation corrosion. The transition from pitting to intergranular corrosion is very slow for specimens heated to 190 °C, but accelerates slightly as the cooling procedure proceeds. The transition to exfoliation corrosion is observed to be quite slow in all specimens in non-isothermal aged to over-aged condition, suggesting a corrosion resistance comparable to that of RRA condition. PMID:29751493

Atomic-layer-deposited Al2O3 and HfO2 on InAlAs: A comparative study of interfacial and electrical characteristics

NASA Astrophysics Data System (ADS)

Wu, Li-Fan; Zhang, Yu-Ming; Lv, Hong-Liang; Zhang, Yi-Men

2016-10-01

Al2O3 and HfO2 thin films are separately deposited on n-type InAlAs epitaxial layers by using atomic layer deposition (ALD). The interfacial properties are revealed by angle-resolved x-ray photoelectron spectroscopy (AR-XPS). It is demonstrated that the Al2O3 layer can reduce interfacial oxidation and trap charge formation. The gate leakage current densities are 1.37 × 10-6 A/cm2 and 3.22 × 10-6 A/cm2 at +1 V for the Al2O3/InAlAs and HfO2/InAlAs MOS capacitors respectively. Compared with the HfO2/InAlAs metal-oxide-semiconductor (MOS) capacitor, the Al2O3/InAlAs MOS capacitor exhibits good electrical properties in reducing gate leakage current, narrowing down the hysteresis loop, shrinking stretch-out of the C-V characteristics, and significantly reducing the oxide trapped charge (Q ot) value and the interface state density (D it). Project supported by the National Basic Research Program of China (Grant No. 2010CB327505), the Advanced Research Foundation of China (Grant No. 914xxx803-051xxx111), the National Defense Advance Research Project, China (Grant No. 513xxxxx306), the National Natural Science Foundation of China (Grant No. 51302215), the Scientific Research Program Funded by Shaanxi Provincial Education Department, China (Grant No. 14JK1656), and the Science and Technology Project of Shaanxi Province, China (Grant No. 2016KRM029).

Novel Connections Between DNA Replication, Telomere Homeostasis, and the DNA Damage Response Revealed by a Genome-Wide Screen for TEL1/ATM Interactions in Saccharomyces cerevisiae

PubMed Central

Piening, Brian D.; Huang, Dongqing; Paulovich, Amanda G.

2013-01-01

Tel1 is the budding yeast ortholog of the mammalian tumor suppressor and DNA damage response (DDR) kinase ATM. However, tel1-Δ cells, unlike ATM-deficient cells, do not exhibit sensitivity to DNA-damaging agents, but do display shortened (but stably maintained) telomere lengths. Neither the extent to which Tel1p functions in the DDR nor the mechanism by which Tel1 contributes to telomere metabolism is well understood. To address the first question, we present the results from a comprehensive genome-wide screen for genetic interactions with tel1-Δ that cause sensitivity to methyl methanesulfonate (MMS) and/or ionizing radiation, along with follow-up characterizations of the 13 interactions yielded by this screen. Surprisingly, many of the tel1-Δ interactions that confer DNA damage sensitivity also exacerbate the short telomere phenotype, suggesting a connection between these two phenomena. Restoration of normal telomere length in the tel1-Δ xxx-Δ mutants results in only minor suppression of the DNA damage sensitivity, demonstrating that the sensitivity of these mutants must also involve mechanisms independent of telomere length. In support of a model for increased replication stress in the tel1-Δ xxx-Δ mutants, we show that depletion of dNTP pools through pretreatment with hydroxyurea renders tel1-Δ cells (but not wild type) MMS-sensitive, demonstrating that, under certain conditions, Tel1p does indeed play a critical role in the DDR. PMID:23378069

Incidence of X and Y Chromosomal Aneuploidy in a Large Child Bearing Population

PubMed Central

Kırkızlar, Eser; Hall, Megan P.; Demko, Zachary; Zneimer, Susan M.; Curnow, Kirsten J.; Gross, Susan; Gropman, Andrea

2016-01-01

Background X&Y chromosomal aneuploidies are among the most common human whole-chromosomal copy number changes, but the population-based incidence and prevalence in the child-bearing population is unclear. Methods This retrospective analysis of prospectively collected data leveraged a routine non-invasive prenatal test (NIPT) using parental genotyping to estimate the population-based incidence of X&Y chromosome variations in this population referred for NIPT (generally due to advanced maternal age). Results From 141,916 women and 29,336 men, 119 X&Y chromosomal abnormalities (prevalence: 1 in 1,439) were identified. Maternal findings include: 43 cases of 45,X (40 mosaic); 30 cases of 47,XXX (12 mosaic); 3 cases of 46,XX uniparental disomy; 2 cases of 46,XY/46,XX; 23 cases of mosaicism of unknown type; 2 cases of 47,XX,i(X)(q10). Paternal findings include: 2 cases of 47,XXY (1 mosaic); 10 cases of 47,XYY (1 mosaic); 4 partial Y deletions. Conclusions Single chromosome aneuploidy was present in one of every 1,439 individuals considered in this study, showing 47,XXX; 47,XX,i(X)(q10); 47,XYY; 47,XXY, partial Y deletions, and a high level of mosaicism for 45,X. This expands significantly our understanding of X&Y chromosomal variations and fertility issues, and is critical for families and adults affected by these disorders. This current and extensive information on fertility will be beneficial for genetic counseling on prenatal diagnoses as well as for newly diagnosed postnatal cases. PMID:27512996

A case-control study of brain structure and behavioral characteristics in 47,XXX syndrome.

PubMed

Lenroot, R K; Blumenthal, J D; Wallace, G L; Clasen, L S; Lee, N R; Giedd, J N

2014-11-01

Trisomy X, the presence of an extra X chromosome in females (47,XXX), is a relatively common but under-recognized chromosomal disorder associated with characteristic cognitive and behavioral features of varying severity. The objective of this study was to determine whether there were neuroanatomical differences in girls with Trisomy X that could relate to cognitive and behavioral differences characteristic of the disorder during childhood and adolescence. MRI scans were obtained on 35 girls with Trisomy X (mean age 11.4, SD 5.5) and 70 age- and sex-matched healthy controls. Cognitive and behavioral testing was also performed. Trisomy X girls underwent a semi-structured psychiatric interview. Regional brain volumes and cortical thickness were compared between the two groups. Total brain volume was significantly decreased in subjects with Trisomy X, as were all regional volumes with the exception of parietal gray matter. Differences in cortical thickness had a mixed pattern. The subjects with Trisomy X had thicker cortex in bilateral medial prefrontal cortex and right medial temporal lobe, but decreased cortical thickness in both lateral temporal lobes. The most common psychiatric disorders present in this sample of Trisomy X girls included anxiety disorders (40%), attention-deficit disorder (17%) and depressive disorders (11%). The most strongly affected brain regions are consistent with phenotypic characteristics such as language delay, poor executive function and heightened anxiety previously described in population-based studies of Trisomy X and also found in our sample. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.

Microstructure Evolution and the Resulted Influence on Localized Corrosion in Al-Zn-Mg-Cu Alloy during Non-Isothermal Ageing.

PubMed

Chen, Jun-Zhou; Li, Guo-Ai; Cai, Xin; Jiang, Jian-Tang; Shao, Wen-Zhu; Yang, Li; Zhen, Liang

2018-05-03

A non-isothermal ageing process was proposed for an Al-Zn-Mg-Cu alloy aiming to accommodate the slow heating/cooling procedure during the ageing of large components. The evolution of microstructure and microchemistry was analyzed by using transmission electron microscopy, high-angle annular dark field imaging, and energy dispersive spectrometry. The age-hardening of the alloy was examined to evaluate the strengthening behavior during the non-isothermal process. The corrosion behavior was investigated via observing the specimens immersed in EXCO solution (solution for Exfoliation Corrosion Susceptibility test in 2xxx and 7xxx series aluminum alloys, referring ASTM G34-01). Secondary precipitation was observed during the cooling stage, leading to increased precipitate number density. The distribution of grain boundary precipitates transits from discontinuous to continuous at the cooling stage, due to the secondary precipitation’s linking-up effect. The solutes’ enrichment on grain boundary precipitates and the depletion in precipitate-free zones develops during the heating procedure, but remains invariable during the cooling procedure. The corrosion in NIA (Non-isothermal Ageing) treated specimens initiates from pitting and then transits to intergranular corrosion and exfoliation corrosion. The transition from pitting to intergranular corrosion is very slow for specimens heated to 190 °C, but accelerates slightly as the cooling procedure proceeds. The transition to exfoliation corrosion is observed to be quite slow in all specimens in non-isothermal aged to over-aged condition, suggesting a corrosion resistance comparable to that of RRA condition.

Exoplanet Biosignatures: A Review of Remotely Detectable Signs of Life.

PubMed

Schwieterman, Edward W; Kiang, Nancy Y; Parenteau, Mary N; Harman, Chester E; DasSarma, Shiladitya; Fisher, Theresa M; Arney, Giada N; Hartnett, Hilairy E; Reinhard, Christopher T; Olson, Stephanie L; Meadows, Victoria S; Cockell, Charles S; Walker, Sara I; Grenfell, John Lee; Hegde, Siddharth; Rugheimer, Sarah; Hu, Renyu; Lyons, Timothy W

2018-05-04

In the coming years and decades, advanced space- and ground-based observatories will allow an unprecedented opportunity to probe the atmospheres and surfaces of potentially habitable exoplanets for signatures of life. Life on Earth, through its gaseous products and reflectance and scattering properties, has left its fingerprint on the spectrum of our planet. Aided by the universality of the laws of physics and chemistry, we turn to Earth's biosphere, both in the present and through geologic time, for analog signatures that will aid in the search for life elsewhere. Considering the insights gained from modern and ancient Earth, and the broader array of hypothetical exoplanet possibilities, we have compiled a comprehensive overview of our current understanding of potential exoplanet biosignatures, including gaseous, surface, and temporal biosignatures. We additionally survey biogenic spectral features that are well known in the specialist literature but have not yet been robustly vetted in the context of exoplanet biosignatures. We briefly review advances in assessing biosignature plausibility, including novel methods for determining chemical disequilibrium from remotely obtainable data and assessment tools for determining the minimum biomass required to maintain short-lived biogenic gases as atmospheric signatures. We focus particularly on advances made since the seminal review by Des Marais et al. The purpose of this work is not to propose new biosignature strategies, a goal left to companion articles in this series, but to review the current literature, draw meaningful connections between seemingly disparate areas, and clear the way for a path forward. Key Words: Exoplanets-Biosignatures-Habitability markers-Photosynthesis-Planetary surfaces-Atmospheres-Spectroscopy-Cryptic biospheres-False positives. Astrobiology 18, xxx-xxx.

Kinetic analysis of contralateral liver hypertrophy after radioembolization of primary and metastatic liver tumors.

PubMed

Orcutt, Sonia T; Abuodeh, Yazan; Naghavi, Arash; Frakes, Jessica; Hoffe, Sarah; Kis, Bela; Anaya, Daniel A

2018-05-01

Radioembolization induces liver hypertrophy, although the extent and rate of hypertrophy are unknown. Our goal was to examine the kinetics of contralateral liver hypertrophy after transarterial radioembolization. A retrospective study (2010-2014) of treatment-naïve patients with primary/secondary liver malignancies undergoing right lobe radioembolization was performed. Computed tomography volumetry was performed before and 1, 3, and 6 months after radioembolization. Outcomes of interest were left lobe (standardized future liver remnant) degree of hypertrophy, kinetic growth rate, and ability to reach goal standardized future liver remnant ≥40%. Medians were compared with the Kruskall-Wallis test. Time to event analysis was used to estimate time to reach goal standardized future liver remnant. In the study, 25 patients were included. At 1, 3, and 6 months, median degree of hypertrophy was 4%, 8%, and 12% (P < .001), degree of hypertrophy relative to baseline future liver remnants was 11%, 17%, and 31% (P = .015), and kinetic growth rate was 0.8%, 0.5%, and 0.4%/week (P = .002). In patients with baseline standardized future liver remnant <40% (N= 16), median time to reach standardized future liver remnant ≥40% was 7.3 months, with 75% accomplishing standardized future liver remnant ≥40% at 8.2 months. Radioembolization induces hypertrophy of the contralateral lobe to a similar extent as existing methods, although at a lower rate. The role of radioembolization as a dual therapy (neoadjuvant and hypetrophy-inducing) for selected patients needs to be studied. (Surgery 2017;160:XXX-XXX.). Copyright © 2017 Elsevier Inc. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garifullin, R. N., E-mail: rustem@matem.anrb.ru; Suleimanov, B. I., E-mail: bisul@mail.r

An analysis is presented of the effect of weak dispersion on transitions from weak to strong discontinuities in inviscid fluid dynamics. In the neighborhoods of transition points, this effect is described by simultaneous solutions to the Korteweg-de Vries equation u{sub t}'+ uu{sub x}' + u{sub xxx}' = 0 and fifth-order nonautonomous ordinary differential equations. As x{sup 2} + t{sup 2} {yields}{infinity}, the asymptotic behavior of these simultaneous solutions in the zone of undamped oscillations is given by quasi-simple wave solutions to Whitham equations of the form r{sub i}(t, x) = tl{sub i} x/t{sup 2}.

Infrared Observations of the Solar System in Support of Large Aperture Infrared Telescope (LARITS): Calibration. Appendices

DTIC Science & Technology

1990-04-01

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Transportation Career Field, AFSC 60XXX

DTIC Science & Technology

1988-04-01

equipment, affixirg parachutes and extraction systems to airdrop loads, * rigging cargo on platforms for airdrops, assembling extraction systems and attaching...C Z= C4 (D Il L-. Ill CD Ill l "- 1i CD P-4J (i 0D CL .J wIX I- In V -i W I L 0e W Z-I -I 7-1 . C-) 1W ID .. C> LL w C) 10 C- = CDCt l 1) 0 < W...PERCENT MEMBERS PERFORMING PERCENT , MEMBERS ’ TASKS PERFORMING M1129 AFFIX PARACHUTES TO AIRDROP LOADS 99 M1149 RIG CARGO ON PLATFORMS FOR AIRDROPS 96

The Influences of Quantum Coherence on the Positive Work and the Efficiency of Quantum Heat Engine with Working Substance of Two-Qubit Heisenberg XXX Model

NASA Astrophysics Data System (ADS)

Peng, Hu-Ping; Fang, Mao-Fa; Yu, Min; Zou, Hong-Mei

2018-03-01

We study the influences of quantum coherence on the positive work and the efficiency of quantum heat engine (QHE) based on working substance of two-qubit Heisenberg model under a constant external magnetic field. By using analytical and numerical solution, we give the relation expressions for both the positive work and the efficiency with quantum coherence, and in detail discuss the effects of the quantum coherence on the positive work and the efficiency of QHE in the absence or presence of external magnetic field, respectively.