Food and drink consumption among 1-5-year-old Los Angeles County children from households receiving dual SNAP and WIC v. only WIC benefits.

PubMed

Liu, Jane; Kuo, Tony; Jiang, Lu; Robles, Brenda; Whaley, Shannon E

2017-10-01

The Supplemental Nutrition Assistance Program (SNAP) and the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) are two of the more well-known food assistance programmes in the USA. The current study describes food consumption patterns of children aged 1-5 years living in households dually enrolled in these two programmes v. households enrolled only in WIC. Food consumption and SNAP participation were assessed using data from the 2014 Survey of Los Angeles County (LAC) WIC Participants and the Follow-Up Survey of the same households that were also SNAP beneficiaries. Telephone interviews were conducted with WIC parents regarding each child's (i.e. beneficiary's) food consumption patterns. Follow-up interviews were conducted with those who reported receiving SNAP. Multivariable regression analyses were performed to assess the relationships between food and beverage consumption and dual v. single food assistance programme participation. LAC, California. Children of WIC-enrolled households in LAC during 2014 (n 3248). This included a sub-sample of dual WIC- and SNAP-enrolled households (n 1295). Survey participants were the beneficiaries' parents. Children from dually enrolled households consumed 1·03 (P<0·05) and 1·04 (P<0·01) more servings of fruits and vegetables daily respectively, 1·07 more sugar-sweetened beverages daily (P<0·001) and ate sweets/sweetened foods 1·04 more times daily (P<0·001) than children from households participating only in WIC. Results suggest that SNAP+WIC enrolment is associated with increased consumption of both healthy foods and foods containing minimal nutritional value. Complementary nutrition education efforts across the two programmes may help beneficiaries maximize healthful food purchases with SNAP dollars.

Significant New Alternatives Policy (SNAP)

EPA Pesticide Factsheets

These webpages provide information on EPA’s Significant New Alternatives Policy (SNAP) program which evaluates substitutes for ozone-depleting substances in major industrial use sectors. The SNAP program promotes a smooth transition to safer alternatives.

SNAP-25 IN NEUROPSYCHIATRIC DISORDERS

PubMed Central

Corradini, Irene; Verderio, Claudia; Sala, Mariaelvina; Wilson, Michael C.; Matteoli, Michela

2009-01-01

SNAP-25 is plasma membrane protein which, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE docking complex for regulated exocytosis. SNAP-25 also modulates different voltage-gated calcium channels, representing therefore a multifunctional protein that plays essential roles in neurotransmitter release at different steps. Recent genetic studies of human populations and of some mouse models implicate that alterations in SNAP-25 gene structure, expression and/or function may contribute directly to these distinct neuropsychiatric and neurological disorders. PMID:19161380

Revised SNAP III Training Manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moss, Calvin Elroy; Gonzales, Samuel M.; Myers, William L.

The Shielded Neutron Assay Probe (SNAP) technique was developed to determine the leakage neutron source strength of a radioactive object. The original system consisted of an Eberline TM Mini-scaler and discrete neutron detector. The system was operated by obtaining the count rate with the Eberline TM instrument, determining the absolute efficiency from a graph, and calculating the neutron source strength by hand. In 2003 the SNAP III, shown in Figure 1, was designed and built. It required the operator to position the SNAP, and then measure the source-to-detector and detectorto- reflector distances. Next the operator entered the distance measurements andmore » started the data acquisition. The SNAP acquired the required count rate and then calculated and displayed the leakage neutron source strength (NSS). The original design of the SNAP III is described in SNAP III Training Manual (ER-TRN-PLN-0258, Rev. 0, January 2004, prepared by William Baird) This report describes some changes that have been made to the SNAP III. One important change is the addition of a LEMO connector to provide neutron detection output pulses for input to the MC-15. This feature is useful in active interrogation with a neutron generator because the MC-15 has the capability to only record data when it is not gated off by a pulse from the neutron generator. This avoids recording of a lot of data during the generator pulses that are not useful. Another change was the replacement of the infrared RS-232 serial communication output by a similar output via a 4-pin LEMO connector. The current document includes a more complete explanation of how to estimate the amount of moderation around a neutron-emitting source.« less

The Supernovae Analysis Application (SNAP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bayless, Amanda J.; Fryer, Christopher Lee; Wollaeger, Ryan Thomas

The SuperNovae Analysis aPplication (SNAP) is a new tool for the analysis of SN observations and validation of SN models. SNAP consists of a publicly available relational database with observational light curve, theoretical light curve, and correlation table sets with statistical comparison software, and a web interface available to the community. The theoretical models are intended to span a gridded range of parameter space. The goal is to have users upload new SN models or new SN observations and run the comparison software to determine correlations via the website. There are problems looming on the horizon that SNAP is beginningmore » to solve. For example, large surveys will discover thousands of SNe annually. Frequently, the parameter space of a new SN event is unbounded. SNAP will be a resource to constrain parameters and determine if an event needs follow-up without spending resources to create new light curve models from scratch. Second, there is no rapidly available, systematic way to determine degeneracies between parameters, or even what physics is needed to model a realistic SN. The correlations made within the SNAP system are beginning to solve these problems.« less

The Supernovae Analysis Application (SNAP)

DOE PAGES

Bayless, Amanda J.; Fryer, Christopher Lee; Wollaeger, Ryan Thomas; ...

2017-09-06

The SuperNovae Analysis aPplication (SNAP) is a new tool for the analysis of SN observations and validation of SN models. SNAP consists of a publicly available relational database with observational light curve, theoretical light curve, and correlation table sets with statistical comparison software, and a web interface available to the community. The theoretical models are intended to span a gridded range of parameter space. The goal is to have users upload new SN models or new SN observations and run the comparison software to determine correlations via the website. There are problems looming on the horizon that SNAP is beginningmore » to solve. For example, large surveys will discover thousands of SNe annually. Frequently, the parameter space of a new SN event is unbounded. SNAP will be a resource to constrain parameters and determine if an event needs follow-up without spending resources to create new light curve models from scratch. Second, there is no rapidly available, systematic way to determine degeneracies between parameters, or even what physics is needed to model a realistic SN. The correlations made within the SNAP system are beginning to solve these problems.« less

The Supernovae Analysis Application (SNAP)

NASA Astrophysics Data System (ADS)

Bayless, Amanda J.; Fryer, Chris L.; Wollaeger, Ryan; Wiggins, Brandon; Even, Wesley; de la Rosa, Janie; Roming, Peter W. A.; Frey, Lucy; Young, Patrick A.; Thorpe, Rob; Powell, Luke; Landers, Rachel; Persson, Heather D.; Hay, Rebecca

2017-09-01

The SuperNovae Analysis aPplication (SNAP) is a new tool for the analysis of SN observations and validation of SN models. SNAP consists of a publicly available relational database with observational light curve, theoretical light curve, and correlation table sets with statistical comparison software, and a web interface available to the community. The theoretical models are intended to span a gridded range of parameter space. The goal is to have users upload new SN models or new SN observations and run the comparison software to determine correlations via the website. There are problems looming on the horizon that SNAP is beginning to solve. For example, large surveys will discover thousands of SNe annually. Frequently, the parameter space of a new SN event is unbounded. SNAP will be a resource to constrain parameters and determine if an event needs follow-up without spending resources to create new light curve models from scratch. Second, there is no rapidly available, systematic way to determine degeneracies between parameters, or even what physics is needed to model a realistic SN. The correlations made within the SNAP system are beginning to solve these problems.

The Curious Acoustic Behavior of Estuarine Snapping Shrimp: Temporal Patterns of Snapping Shrimp Sound in Sub-Tidal Oyster Reef Habitat.

PubMed

Bohnenstiehl, DelWayne R; Lillis, Ashlee; Eggleston, David B

2016-01-01

Ocean soundscapes convey important sensory information to marine life. Like many mid-to-low latitude coastal areas worldwide, the high-frequency (>1.5 kHz) soundscape of oyster reef habitat within the West Bay Marine Reserve (36°N, 76°W) is dominated by the impulsive, short-duration signals generated by snapping shrimp. Between June 2011 and July 2012, a single hydrophone deployed within West Bay was programmed to record 60 or 30 seconds of acoustic data every 15 or 30 minutes. Envelope correlation and amplitude information were then used to count shrimp snaps within these recordings. The observed snap rates vary from 1500-2000 snaps per minute during summer to <100 snaps per minute during winter. Sound pressure levels are positively correlated with snap rate (r = 0.71-0.92) and vary seasonally by ~15 decibels in the 1.5-20 kHz range. Snap rates are positively correlated with water temperatures (r = 0.81-0.93), as well as potentially influenced by climate-driven changes in water quality. Light availability modulates snap rate on diurnal time scales, with most days exhibiting a significant preference for either nighttime or daytime snapping, and many showing additional crepuscular increases. During mid-summer, the number of snaps occurring at night is 5-10% more than predicted by a random model; however, this pattern is reversed between August and April, with an excess of up to 25% more snaps recorded during the day in the mid-winter. Diurnal variability in sound pressure levels is largest in the mid-winter, when the overall rate of snapping is at its lowest, and the percentage difference between daytime and nighttime activity is at its highest. This work highlights our lack of knowledge regarding the ecology and acoustic behavior of one of the most dominant soniforous invertebrate species in coastal systems. It also underscores the necessity of long-duration, high-temporal-resolution sampling in efforts to understand the bioacoustics of animal behaviors and

The Curious Acoustic Behavior of Estuarine Snapping Shrimp: Temporal Patterns of Snapping Shrimp Sound in Sub-Tidal Oyster Reef Habitat

PubMed Central

Bohnenstiehl, DelWayne R.; Lillis, Ashlee; Eggleston, David B.

2016-01-01

Ocean soundscapes convey important sensory information to marine life. Like many mid-to-low latitude coastal areas worldwide, the high-frequency (>1.5 kHz) soundscape of oyster reef habitat within the West Bay Marine Reserve (36°N, 76°W) is dominated by the impulsive, short-duration signals generated by snapping shrimp. Between June 2011 and July 2012, a single hydrophone deployed within West Bay was programmed to record 60 or 30 seconds of acoustic data every 15 or 30 minutes. Envelope correlation and amplitude information were then used to count shrimp snaps within these recordings. The observed snap rates vary from 1500–2000 snaps per minute during summer to <100 snaps per minute during winter. Sound pressure levels are positively correlated with snap rate (r = 0.71–0.92) and vary seasonally by ~15 decibels in the 1.5–20 kHz range. Snap rates are positively correlated with water temperatures (r = 0.81–0.93), as well as potentially influenced by climate-driven changes in water quality. Light availability modulates snap rate on diurnal time scales, with most days exhibiting a significant preference for either nighttime or daytime snapping, and many showing additional crepuscular increases. During mid-summer, the number of snaps occurring at night is 5–10% more than predicted by a random model; however, this pattern is reversed between August and April, with an excess of up to 25% more snaps recorded during the day in the mid-winter. Diurnal variability in sound pressure levels is largest in the mid-winter, when the overall rate of snapping is at its lowest, and the percentage difference between daytime and nighttime activity is at its highest. This work highlights our lack of knowledge regarding the ecology and acoustic behavior of one of the most dominant soniforous invertebrate species in coastal systems. It also underscores the necessity of long-duration, high-temporal-resolution sampling in efforts to understand the bioacoustics of animal behaviors

Dynamics of snapping beams and jumping poppers

NASA Astrophysics Data System (ADS)

Pandey, A.; Moulton, D. E.; Vella, D.; Holmes, D. P.

2014-01-01

We consider the dynamic snapping instability of elastic beams and shells. Using the Kirchhoff rod and Föppl-von Kármán plate equations, we study the stability, deformation modes, and snap-through dynamics of an elastic arch with clamped boundaries and subject to a concentrated load. For parameters typical of everyday and technological applications of snapping, we show that the stretchability of the arch plays a critical role in determining not only the post-buckling mode of deformation but also the timescale of snapping and the frequency of the arch's vibrations about its final equilibrium state. We show that the growth rate of the snap-through instability and its subsequent ringing frequency can both be interpreted physically as the result of a sound wave in the material propagating over a distance comparable to the length of the arch. Finally, we extend our analysis of the ringing frequency of indented arches to understand the “pop” heard when everted shell structures snap-through to their stable state. Remarkably, we find that not only are the scaling laws for the ringing frequencies in these two scenarios identical but also the respective prefactors are numerically close; this allows us to develop a master curve for the frequency of ringing in snapping beams and shells.

Small Next-Generation Atmospheric Probe (SNAP) Concept

NASA Technical Reports Server (NTRS)

Sayanagi, K. M.; Dillman, R. A.; Simon, A. A.; Atkinson, D. H.; Wong, M. H.; Spilker, T. R.; Saikia, S.; Li, J.; Hope, D.

2017-01-01

We present the Small Next-Generation Atmospheric Probe (SNAP) as a secondary payload concept for future missions to giant planets. As a case study, we examine the advantages, cost and risk of adding SNAP to the future Uranus Orbiter and Probe flag-ship mission; in combination with the missions main probe, SNAP would perform atmospheric in-situ measurements at a second location.

Quantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia

PubMed Central

Barakauskas, Vilte E; Moradian, Annie; Barr, Alasdair M.; Beasley, Clare L; Rosoklija, Gorazd; Mann, J John; Ilievski, Boro; Stankov, Aleksandar; Dwork, Andrew J; Falkai, Peter; Morin, Gregg B; Honer, William G

2016-01-01

SNAP-25 and syntaxin are presynaptic terminal SNARE proteins altered in amount and function in schizophrenia. In the ventral caudate, we observed 32% lower SNAP-25 and 26% lower syntaxin, but greater interaction between the two proteins using an in vitro assay. SNAP-25 has two isoforms, SNAP-25A and B, differing by only 9 amino acids, but with different effects on neurotransmission. A quantitative mass spectrometry assay was developed to measure total SNAP-25, and proportions of SNAP-25A and B. The assay had a good linear range (50- to 150-fold) and coefficient of variation (4.5%). We studied ventral caudate samples from patients with schizophrenia (n=15) previously reported to have lower total SNAP-25 than controls (n=13). We confirmed 27% lower total SNAP-25 in schizophrenia, and observed 31% lower SNAP-25A (P = 0.002) with 20% lower SNAP-25B amounts (P = 0.10). Lower SNAP-25A amount correlated with greater SNAP-25-syntaxin protein-protein interactions (r = -0.41, P = 0.03); the level of SNAP-25B did not. Administration of haloperidol or clozapine to rats did not mimic the changes found in schizophrenia. The findings suggest that lower levels of SNAP-25 in schizophrenia may represent a greater effect of the illness on the SNAP-25A isoform. This in turn could contribute to the greater interaction between SNAP25 and syntaxin, and possibly disturb neurotransmission in the illness. PMID:26971072

SNAP Benefits: Can an Adequate Benefit Be Defined?123

PubMed Central

Yaktine, Ann L.; Caswell, Julie A.

2014-01-01

The Supplemental Nutrition Assistance Program (SNAP) increases the food purchasing power of participating households. A committee convened by the Institute of Medicine (IOM) examined the question of whether it is feasible to define SNAP allotment adequacy. Total resources; individual, household, and environmental factors; and SNAP program characteristics that affect allotment adequacy were identified from a framework developed by the IOM committee. The committee concluded that it is feasible to define SNAP allotment adequacy; however, such a definition must take into account the degree to which participants’ total resources and individual, household, and environmental factors influence the purchasing power of SNAP benefits and the impact of SNAP program characteristics on the calculation of the dollar value of the SNAP allotment. The committee recommended that the USDA Food and Nutrition Service investigate ways to incorporate these factors and program characteristics into research aimed at defining allotment adequacy. PMID:24425718

7 CFR 63.6 - Fiscal year.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 3 2011-01-01 2011-01-01 false Fiscal year. 63.6 Section 63.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL...

Burden of breast cancer in Cali, Colombia: 1962-2012.

PubMed

Bravo, Luis Eduardo; García, Luz Stella; Carrascal, Edwin; Rubiano, Jaime

2014-01-01

To describe the behavior of breast cancer (BC)during the 1962-2012 period from information provided by the Cali Cancer Registry and the Municipal Health Secretariat of Cali. The incidence trend (1962-2007) and mortality trend (1984-2012) for breast cancer was studied and relative survival (RS)(1995-2004) was estimated. Age-standardized incidence and mortality rates to the world population (ASIR(w)/ASMR(w)) were expressed per 100000 persons-year. Their temporal trend was examined with the annual percent of change (APC), and the Cox model was used to analyze the variables that influenced the survival of women with breast cancer. The risk of breast cancer significantly increased in Cali through the 1962-2007 period, with an APC =1.7(95%CI:1.4-2.0). The ASIR(w) of BC increased from 27.1 in 1962 to 48.0 in 2007 and currently there are more than 500 cases reported annually. The mortality for BC has remained stable since 1984; in the 2009-2012 period, the ASMR(w) was 14.2. The 5-year RS was 69% (95%CI:66-71) from 2000-2004 and 62% (95%CI:59-65) from 1995-1999. The risk of death (HR) from BC was greater in persons from lower socioeconomic strata (SES) than from higher SES, HR=1.9(95%CI:1.3-2.9) and in those older than 70 years vs. <50, HR=1.6(95%CI:1.1-2.2). Mortality remained stable while incidence increased and survival improved, which may be associated with better detection and advances in treatment.

Snap evaporation of droplets on smooth topographies.

PubMed

Wells, Gary G; Ruiz-Gutiérrez, Élfego; Le Lirzin, Youen; Nourry, Anthony; Orme, Bethany V; Pradas, Marc; Ledesma-Aguilar, Rodrigo

2018-04-11

Droplet evaporation on solid surfaces is important in many applications including printing, micro-patterning and cooling. While seemingly simple, the configuration of evaporating droplets on solids is difficult to predict and control. This is because evaporation typically proceeds as a "stick-slip" sequence-a combination of pinning and de-pinning events dominated by static friction or "pinning", caused by microscopic surface roughness. Here we show how smooth, pinning-free, solid surfaces of non-planar topography promote a different process called snap evaporation. During snap evaporation a droplet follows a reproducible sequence of configurations, consisting of a quasi-static phase-change controlled by mass diffusion interrupted by out-of-equilibrium snaps. Snaps are triggered by bifurcations of the equilibrium droplet shape mediated by the underlying non-planar solid. Because the evolution of droplets during snap evaporation is controlled by a smooth topography, and not by surface roughness, our ideas can inspire programmable surfaces that manage liquids in heat- and mass-transfer applications.

Supplemental Nutrition Assistance Program (SNAP) Participation and Health Care Expenditures Among Low-Income Adults.

PubMed

Berkowitz, Seth A; Seligman, Hilary K; Rigdon, Joseph; Meigs, James B; Basu, Sanjay

2017-11-01

Food insecurity is associated with high health care expenditures, but the effectiveness of food insecurity interventions on health care costs is unknown. To determine whether the Supplemental Nutrition Assistance Program (SNAP), which addresses food insecurity, can reduce health care expenditures. This is a retrospective cohort study of 4447 noninstitutionalized adults with income below 200% of the federal poverty threshold who participated in the 2011 National Health Interview Survey (NHIS) and the 2012-2013 Medical Expenditure Panel Survey (MEPS). Self-reported SNAP participation in 2011. Total health care expenditures (all paid claims and out-of-pocket costs) in the 2012-2013 period. To test whether SNAP participation was associated with lower subsequent health care expenditures, we used generalized linear modeling (gamma distribution, log link, with survey design information), adjusting for demographics (age, gender, race/ethnicity), socioeconomic factors (income, education, Social Security Disability Insurance disability, urban/rural), census region, health insurance, and self-reported medical conditions. We also conducted sensitivity analyses as a robustness check for these modeling assumptions. A total of 4447 participants (2567 women and 1880 men) were enrolled in the study, mean (SE) age, 42.7 (0.5) years; 1889 were SNAP participants, and 2558 were not. Compared with other low-income adults, SNAP participants were younger (mean [SE] age, 40.3 [0.6] vs 44.1 [0.7] years), more likely to have public insurance or be uninsured (84.9% vs 67.7%), and more likely to be disabled (24.2% vs 10.6%) (P < .001 for all). In age- and gender-adjusted models, health care expenditures between those who did and did not participate in SNAP were similar (difference, $34; 95% CI, -$1097 to $1165). In fully adjusted models, SNAP was associated with lower estimated annual health care expenditures (-$1409; 95% CI, -$2694 to -$125). Sensitivity analyses were consistent with

Radioactivity of Water in Poland in 1962; RADIOAKTYWNOSC WOD W POLSCE W 1962 ROKU

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wlodek, St.; Grzybowska, D.

1963-01-01

Data are presented on the BETA radioactivity of 358 water samples collected throughout Poland during 1962. It was estimated that water radioactivity was directiy proportional to river levels and inversely proportional to the temperature of the water. Data on gross BETA activity of samples collected from 1958 through 1962 are compared. (C.H.)

7 CFR 63.6 - Fiscal year.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 3 2013-01-01 2013-01-01 false Fiscal year. 63.6 Section 63.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG...

7 CFR 63.6 - Fiscal year.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 3 2012-01-01 2012-01-01 false Fiscal year. 63.6 Section 63.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG...

7 CFR 63.6 - Fiscal year.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 3 2014-01-01 2014-01-01 false Fiscal year. 63.6 Section 63.6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG...

Characteristics of Supplemental Nutrition Assistance Program Households: Fiscal Year 2012. Nutrition Assistance Program Report Series. No. SNAP-14-CHAR

ERIC Educational Resources Information Center

Gray, Kelsey Farson; Eslami, Esa

2014-01-01

The Supplemental Nutrition Assistance Program (SNAP) serves as the foundation of America's national nutrition safety net. It is the nation's first line of defense against food insecurity and offers a powerful tool to improve nutrition among low-income individuals. SNAP is the largest of the 15 domestic food and nutrition assistance programs…

Rewarding Healthy Food Choices in SNAP: Behavioral Economic Applications

PubMed Central

Richards, Michael R; Sindelar, Jody L

2013-01-01

Context American obesity rates continue to escalate, but an effective policy response remains elusive. Specific changes to the Supplemental Nutrition Assistance Program (SNAP) have been proposed as one way to improve nutrition and combat obesity among lower-income populations. While current SNAP proposals hold promise, some important challenges still remain. Methods We discuss the four most common recommendations for changes to SNAP and their benefits and limitations. We then propose three new delivery options for SNAP that take advantage of behavioral economic insights and encourage the selection of healthy foods. Findings Although the existing proposals could help SNAP recipients, they often do not address some important behavioral impediments to buying healthy foods. We believe that behavioral economics can be used to design alternative policies with several advantages, although we recognize and discuss some of their limitations. The first proposal rewards healthy purchases with more SNAP funds and provides an additional incentive to maintain healthier shopping patterns. The second proposal uses the opportunity to win prizes to reward healthy food choices, and the prizes further support healthier habits. The final proposal simplifies healthy food purchases by allowing individuals to commit their SNAP benefits to more nutritious selections in advance. Conclusions Reforming the delivery structure of SNAP's benefits could help improve nutrition, weight, and overall health of lower-income individuals. We advocate for more and diverse SNAP proposals, which should be tested and, possibly, combined. Their implementation, however, would require political will, administrative capacity, and funding. PMID:23758515

40 CFR 63.76 - Review of base year emissions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 9 2011-07-01 2011-07-01 false Review of base year emissions. 63.76... Governing Compliance Extensions for Early Reductions of Hazardous Air Pollutants § 63.76 Review of base year... approve or disapprove base year emission data submitted in an enforceable commitment under § 63.75 or in a...

40 CFR 63.76 - Review of base year emissions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 10 2012-07-01 2012-07-01 false Review of base year emissions. 63.76... Governing Compliance Extensions for Early Reductions of Hazardous Air Pollutants § 63.76 Review of base year... approve or disapprove base year emission data submitted in an enforceable commitment under § 63.75 or in a...

40 CFR 63.76 - Review of base year emissions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 10 2013-07-01 2013-07-01 false Review of base year emissions. 63.76... Governing Compliance Extensions for Early Reductions of Hazardous Air Pollutants § 63.76 Review of base year... approve or disapprove base year emission data submitted in an enforceable commitment under § 63.75 or in a...

40 CFR 63.76 - Review of base year emissions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Review of base year emissions. 63.76... Governing Compliance Extensions for Early Reductions of Hazardous Air Pollutants § 63.76 Review of base year... approve or disapprove base year emission data submitted in an enforceable commitment under § 63.75 or in a...

Food Insecurity and SNAP Participation in Mexican Immigrant Families: The Impact of the Outreach Initiative

PubMed Central

Kaushal, Neeraj; Waldfogel, Jane; Wight, Vanessa

2016-01-01

We study the factors associated with food insecurity and participation in the Supplemental Nutrition Assistance Program (SNAP) in Mexican immigrant families in the US. Estimates from analyses that control for a rich set of economic, demographic, and geographic variables show that children in Mexican immigrant families are more likely to be food insecure than children in native families, but are less likely to participate in SNAP. Further, more vulnerable groups such as the first-generation Mexican immigrant families, families in the US for less than 5 years, and families with non-citizen children – that are at a higher risk of food insecurity are the least likely to participate in SNAP. Our analysis suggests that the US Department of Agriculture outreach initiative and SNAP expansion under the American Recovery and Reinvestment Act increased SNAP participation of the mixed-status Mexican families. We do not find any evidence that the outreach and ARRA expansion increased SNAP receipt among Mexican immigrant families with only non-citizen members who are likely to be undocumented. PMID:27570576

LED Illuminators for the SNAP Calibration

NASA Astrophysics Data System (ADS)

Misra, Amit; Baptista, B.; Mufson, S.; Mostek, N.

2007-12-01

The Supernova Acceleration Probe, or SNAP, is a proposed satellite mission that will study dark energy to better understand what is driving the universe's accelerated expansion. One of the goals of SNAP is to control systematic color uncertainties to less than 2%. The work described here is directed at the development of a flight calibration illumination system for SNAP that minimizes systematic errors in color. The system is based on LEDs as the illumination lamps. LEDs are compact, long-lived, and low power illuminators, which make them attractive for space missions lasting several years. This poster discusses optical measurements of pulsed, thermally controlled LEDs obtained from commercial vendors. Measurements over short (over the span of one day) and long (over the span of weeks) time scales have shown that the irradiance of the LEDs we tested is constant at the 0.3% level. In these measurements we paid particular attention to the influence of junction heating. Measurements of LED irradiance versus the duty cycle of the pulsed LED show that in general the LED irradiance increases as the junction temperature increases. Additionally, the FWHM of the spectrum also increases as the temperature increases. However, measurements of LED irradiance versus temperature as regulated a by a thermal controller circuit, show that the LED irradiance decreases as the temperature increases. This work has been supported by the National Science Foundation under grant AST-0452975 (REU-Site to Indiana U.).

Endoscopic treatment of snapping hips, iliotibial band, and iliopsoas tendon.

PubMed

Ilizaliturri, Victor M; Camacho-Galindo, Javier

2010-06-01

Indications for endoscopic surgery of the hip have expanded recently. The technique has found a clear indication in the management of snapping hip syndromes, both external snapping hip and internal snapping hip. Even though the snapping hips (external and internal) share a common name, they are very different in origin. The external snapping hip is produced by the iliotibial band snapping over the prominence of the greater trochanter during flexion and extension. Indication for surgical treatment is painful snapping with failure of conservative treatment. The endoscopic technique is designed to release the iliotibial band producing a diamond shape defect on the iliotibial band lateral to the greater trochanter. The defect allows the greater trochanter to move freely without snapping. The greater trochanteric bursa is resected through the defect and the abductor tendons inspected. This procedure is performed without traction and usually only the peritrochanteric space is accessed. If necessary, hip arthroscopy can also be performed. There is limited literature regarding the results of endoscopic treatment for the external snapping hip syndrome, but early reports are encouraging. The internal snapping hip syndrome is produced by the iliopsoas tendon snapping over the iliopectineal eminence or the femoral head. The snapping phenomenon usually occurs with extension of the hip from a flexed position of more than 90 degree. Two different endoscopic techniques have been described to treat this condition. Iliopsoas tendon release at the level of the hip joint, with this technique the iliopsoas bursa is accessed through an anterior hip capsulotomy and is frequently referred to as a transcapsular release. The second technique is a release at the insertion of the iliopsoas tendon on the lesser trochanter, with this technique the iliospaos bursa is accessed directly. In every report the iliopsoas tendon release has been combined with arthroscopy of the hip joint. It has been

SNAP-8 electrical generating system development program

NASA Technical Reports Server (NTRS)

1971-01-01

The SNAP-8 program has developed the technology base for one class of multikilowatt dynamic space power systems. Electrical power is generated by a turbine-alternator in a mercury Rankine-cycle loop to which heat is transferred and removed by means of sodium-potassium eutectic alloy subsystems. Final system overall criteria include a five-year operating life, restartability, man rating, and deliverable power in the 90 kWe range. The basic technology has been demonstrated by more than 400,000 hours of major component endurance testing and numerous startup and shutdown cycles. A test system, comprised of developed components, delivered up to 35 kWe for a period exceeding 12,000 hours. The SNAP-8 system baseline is considered to have achieved a level of technology suitable for final application development for long-term multikilowatt space missions.

SNAP-8 electrical generating system development program

NASA Technical Reports Server (NTRS)

1971-01-01

The SNAP-8 program has developed the technology base for one class of multikilowatt dynamic space power systems. Electrical power is generated by a turbine-alternator in a mercury Rankine-cycle loop to which heat is transferred and removed by means of sodium-potassium eutectic alloy subsystems. Final system overall criteria include a five-year operating life, restartability, man rating, and deliverable power in the 90 kWe range. The basic technology was demonstrated by more than 400,000 hours of major component endurance testing and numerous startup and shutdown cycles. A test system, comprised of developed components, delivered up to 35 kWe for a period exceeding 12,000 hours. The SNAP-8 system baseline is considered to have achieved a level of technology suitable for final application development for long-term multikilowatt space missions.

SNAP Cuts Put Youth at Risk

ERIC Educational Resources Information Center

Lower-Basch, Elizabeth

2013-01-01

In a typical month in 2011, the Supplemental Nutrition Assistance Program (SNAP, formerly known as the Food Stamp Program) served 4.3 million low-income young adults ages 18-24, helping them buy needed groceries. This brief report demonstrates the detrimental impact the cuts proposed to SNAP in the House-passed Farm bill (H.R. 3102)--which is now…

Identification and Characterization of Botulinum Neurotoxin A Substrate Binding Pockets and Their Re-Engineering for Human SNAP-23.

PubMed

Sikorra, Stefan; Litschko, Christa; Müller, Carina; Thiel, Nadine; Galli, Thierry; Eichner, Timo; Binz, Thomas

2016-01-29

Botulinum neurotoxins (BoNTs) are highly potent bacterial proteins that block neurotransmitter release at the neuromuscular junction by cleaving SNAREs (soluble N-ethyl maleimide sensitive factor attachment protein receptors). However, their serotype A (BoNT/A) that cleaves SNAP-25 (synaptosomal-associated protein of 25 kDa) has also been an established pharmaceutical for treatment of medical conditions that rely on hyperactivity of cholinergic nerve terminals for 25 years. The expansion of its use to a variety of further medical conditions associated with hypersecretion components is prevented partly because the involved SNARE isoforms are not cleaved. Therefore, we examined by mutational analyses the reason for the resistance of human SNAP-23, an isoform of SNAP-25. We show that replacement of 10 SNAP-23 residues with their SNAP-25 counterparts effects SNAP-25-like cleavability. Conversely, transfer of each of the replaced SNAP-23 residues to SNAP-25 drastically decreased the cleavability of SNAP-25. By means of the existing SNAP-25-toxin co-crystal structure, molecular dynamics simulations, and corroborative mutagenesis studies, the appropriate binding pockets for these residues in BoNT/A were characterized. Systematic mutagenesis of two major BoNT/A binding pockets was conducted in order to adapt these pockets to corresponding amino acids of human SNAP-23. Human SNAP-23 cleaving mutants were isolated using a newly established yeast-based screening system. This method may be useful for engineering novel BoNT/A pharmaceuticals for the treatment of diseases that rely on SNAP-23-mediated hypersecretion. Copyright © 2015 Elsevier Ltd. All rights reserved.

Global Curvature Buckling and Snapping of Spherical Shells.

NASA Astrophysics Data System (ADS)

Pezzulla, Matteo; Stoop, Norbert; Steranka, Mark; Bade, Abdikhalaq; Trejo, Miguel; Holmes, Douglas

A spherical shell under external pressure will eventually buckle locally through the development of a dimple. However, when a free spherical shell is subject to variations in natural curvature, it will either buckle globally or snap towards a buckled configuration. We study the similarities and differences between pressure and curvature instabilities in spherical shells. We show how the critical buckling natural curvature is largely independent of the thinness and half-angle of the shell, while the critical snapping natural curvature grows linearly with the half-angle. As a result, we demonstrate how a critical half-angle, depending only on the thinness of the shell, sets the threshold between two different kinds of snapping: as a rule of thumb, shallow shells snap into everted shells, while deep shells snap into buckled shells. As the developed models are purely geometrical, the results are applicable to a large variety of stimuli and scales. NSF CAREER CMMI-1454153.

Ticks (Ixodidae) on migrating birds in Egypt, spring and fall 1962*

PubMed Central

Hoogstraal, Harry; Traylor, Melvin A.; Gaber, Sobhy; Malakatis, George; Guindy, Ezzat; Helmy, Ibrahim

1964-01-01

Over a number of years studies have been carried out in Egypt on the transport by migrating birds of ticks that may transmit pathogens of man and animals. In continuation of these investigations 11 036 birds migrating southwards through Egypt were examined for ticks during the fall of 1962. The 881 infested birds (comprising 24 species and sub-species represented by 10 612 individuals) yielded 1442 ticks. Tick-host relationships were similar to those of previous years except that in 1962 the prevalence of infestation was almost invariably much higher than the averages for 1959-61. Five species of birds were added to the previous list of 40 infested forms. Previously unrecorded tick species taken during 1962 were Ixodes redikorzevi (a species from Asia very occasionally found in rodent burrows in Egypt), the rare Haemaphysalis inermis, and Hyalomma a. anatolicum, H. anatolicum excavatum and H. dromedarii, which may have been carried from Asia or have attached themselves to the birds at the time of netting. During the spring of 1962, altogether 1774 birds migrating northwards through Egypt were also examined. The 56 tick-infested birds (comprising 13 species represented by 867 individuals) yielded 186 ticks. As in previous years, Hyalomma marginatum rufipes was the chief species (89.25%) parasitizing spring migrants. A single specimen of Amblyomma variegatum was taken on Anthus cervinus and 19 specimens of Ixodes?sp. nov. were collected from Sylvia c. communis and Motacilla a. alba. PMID:14163959

Change of name for the Oriental robber fly Nyssomyia Hull, 1962 (Diptera: Asilidae, Asilinae), nec Nyssomyia Barretto, 1962 (Diptera: Psychodidae, Phlebotominae).

PubMed

Ibáñez-Bernal, Sergio; Fisher, Eric

2015-08-14

A new name for the Oriental genus Nyssomyia Hull, 1962 (Diptera: Asilidae) is proposed. Homonymy exists between this Oriental robber fly genus and the more senior Neotropical phlebotomine sand fly genus Nyssomyia Barretto, 1962 (sensu Galati 2003) (Diptera: Psychodidae), and the following replacement name is proposed: Ekkentronomyia nom. nov. for Nyssomyia Hull (nec Barretto 1962). Accordingly, a new combination is herein proposed for the only species currently included in this genus: Ekkentronomyia ochracea (Hull, 1962) comb. nov.

Telling our stories: heroin-assisted treatment and SNAP activism in the Downtown Eastside of Vancouver.

PubMed

Boyd, Susan; Murray, Dave; MacPherson, Donald

2017-05-18

This article highlights the experiences of a peer-run group, SALOME/NAOMI Association of Patients (SNAP), that meets weekly in the Downtown Eastside of Vancouver, British Columbia, Canada. SNAP is a unique independent peer- run drug user group that formed in 2011 following Canada's first heroin-assisted treatment trial (HAT), North America Opiate Medication Initiative (NAOMI). SNAP's members are now made up of former research participants who participated in two heroin-assisted trials in Vancouver. This article highlights SNAP members' experiences as research subjects in Canada's second clinical trial conducted in Vancouver, Study to Assess Longer-term Opioid Medication Effectiveness (SALOME), that began recruitment of research participants in 2011. This paper draws on one brainstorming session, three focus groups, and field notes, with the SALOME/NAOMI Association of Patients (SNAP) in late 2013 about their experiences as research subjects in Canada's second clinical trial, SALOME in the DTES of Vancouver, and fieldwork from a 6-year period (March 2011 to February 2017) with SNAP members. SNAP's research draws on research principles developed by drug user groups and critical methodological frameworks on community-based research for social justice. The results illuminate how participating in the SALOME clinical trial impacted the lives of SNAP members. In addition, the findings reveal how SNAP member's advocacy for HAT impacts the group in positive ways. Seven major themes emerged from the analysis of the brainstorming and focus groups: life prior to SALOME, the clinic setting and routine, stability, 6-month transition, support, exiting the trial and ethics, and collective action, including their participation in a constitutional challenge in the Supreme Court of BC to continue receiving HAT once the SALOME trial ended. HAT benefits SNAP members. They argue that permanent HAT programs should be established in Canada because they are an effective harm reduction

Minnesota Land Ownership Trends, 1962-1977

Treesearch

Pamela J. Jakes; Alexander Vasilevsky

1980-01-01

The distribution of Minnesota's commercial forest land among ownership classes has remained stable between 1962 and 1977. This note summarizes commercial forest ownership data by Forest Survey Unit for 1962 and 1977 and presents more detailed area statistics for Minnesota's 17 northern countries.

Extending the accuracy of the SNAP interatomic potential form

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wood, Mitchell A.; Thompson, Aidan P.

The Spectral Neighbor Analysis Potential (SNAP) is a classical interatomic potential that expresses the energy of each atom as a linear function of selected bispectrum components of the neighbor atoms. An extension of the SNAP form is proposed that includes quadratic terms in the bispectrum components. The extension is shown to provide a large increase in accuracy relative to the linear form, while incurring only a modest increase in computational cost. The mathematical structure of the quadratic SNAP form is similar to the embedded atom method (EAM), with the SNAP bispectrum components serving as counterparts to the two-body density functionsmore » in EAM. It is also argued that the quadratic SNAP form is a special case of an artificial neural network (ANN). The effectiveness of the new form is demonstrated using an extensive set of training data for tantalum structures. Similarly to ANN potentials, the quadratic SNAP form requires substantially more training data in order to prevent overfitting, as measured by cross-validation analysis.« less

Extending the accuracy of the SNAP interatomic potential form

DOE PAGES

Wood, Mitchell A.; Thompson, Aidan P.

2018-03-28

The Spectral Neighbor Analysis Potential (SNAP) is a classical interatomic potential that expresses the energy of each atom as a linear function of selected bispectrum components of the neighbor atoms. An extension of the SNAP form is proposed that includes quadratic terms in the bispectrum components. The extension is shown to provide a large increase in accuracy relative to the linear form, while incurring only a modest increase in computational cost. The mathematical structure of the quadratic SNAP form is similar to the embedded atom method (EAM), with the SNAP bispectrum components serving as counterparts to the two-body density functionsmore » in EAM. It is also argued that the quadratic SNAP form is a special case of an artificial neural network (ANN). The effectiveness of the new form is demonstrated using an extensive set of training data for tantalum structures. Similarly to ANN potentials, the quadratic SNAP form requires substantially more training data in order to prevent overfitting, as measured by cross-validation analysis.« less

Operation DOMINIC I-1962.

DTIC Science & Technology

1983-02-01

ISLAND DANGER AREA IS A CIRCLE WITH RADII" JOHNSTON ISLAND (1) 470 nm- ( 871 km) 30 APRIL-12 JUNE 1962 AND DANGER AREA 22 SEPTEMBER-1S OCTOBER 1962 (21...AFCRL. Prolect Report: Reference C. 2018 . .I Project 6.4 -- E- and F-Region Physical Chemistry Agencies: Air Force Cambtidge Research Laboratory (AFCRL...1076) USS RECLAIMER (ARS-42) LISSTO LOVANA (AO- 64) 0USS GURKE (00-783) 2 - USS HALSEY POWELL (DO-686) aJ H I TM SI L N SURFACE ZERO S10- 0 30 60 Go

7 CFR 1962.16 - Accounting by County Supervisor.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 14 2010-01-01 2009-01-01 true Accounting by County Supervisor. 1962.16 Section 1962... § 1962.16 Accounting by County Supervisor. The Agency will maintain a current record of each borrower's... risk exists. An FO borrower who has been current with the Agency and who has provided chattels as...

SNAP Assay Technology.

PubMed

O'Connor, Thomas P

2015-12-01

The most widely used immunoassay configuration is the enzyme-linked immunosorbent assay (ELISA) because the procedure produces highly sensitive and specific results and generally is easy to use. By definition, ELISAs are immunoassays used to detect a substance (typically an antigen or antibody) in which an enzyme is attached (conjugated) to one of the reactants and an enzymatic reaction is used to amplify the signal if the substance is present. Optimized ELISAs include several steps that are performed in sequence using a defined protocol that typically includes application of sample and an enzyme-conjugated antibody or antigen to an immobilized reagent, followed by wash and enzyme reaction steps. The SNAP assay is an in-clinic device that performs each of the ELISA steps in a timed sequential fashion with little consumer interface. The components and mechanical mechanism of the assay device are described. Detailed descriptions of features of the assay, which minimize nonspecific binding and enhance the ability to read results from weak-positive samples, are given. Basic principles used in assays with fundamentally different reaction mechanisms, namely, antigen-detection, antibody-detection, and competitive assays are given. Applications of ELISA technology, which led to the development of several multianalyte SNAP tests capable of testing for up to 6 analytes using a single-sample and a single-SNAP device are described. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

SNAP: Small Next-generation Atmospheric Probe Concept

NASA Astrophysics Data System (ADS)

Sayanagi, K. M.; Dillman, R. A.; Atkinson, D. H.; Li, J.; Saikia, S.; Simon, A. A.; Spilker, T. R.; Wong, M. H.; Hope, D.

2017-12-01

We present a concept for a small, atmospheric probe that could be flexibly added to future missions that orbit or fly-by a giant planet as a secondary payload, which we call the Small Next-generation Atmospheric Probe (SNAP). SNAP's main scientific objectives are to determine the vertical distribution of clouds and cloud-forming chemical species, thermal stratification, and wind speed as a function of depth. As a case study, we present the advantages, cost and risk of adding SNAP to the future Uranus Orbiter and Probe flagship mission; in combination with the mission's main probe, SNAP would perform atmospheric in-situ measurements at a second location, and thus enable and enhance the scientific objectives recommended by the 2013 Planetary Science Decadal Survey and the 2014 NASA Science Plan to determine atmospheric spatial variabilities. We envision that the science objectives can be achieved with a 30-kg entry probe 0.5m in diameter (less than half the size of the Galileo probe) that reaches 5-bar pressure-altitude and returns data to Earth via the carrier spacecraft. As the baseline instruments, the probe will carry an Atmospheric Structure Instrument (ASI) that measures the temperature, pressure and acceleration, a carbon nanotube-based NanoChem atmospheric composition sensor, and an Ultra-Stable Oscillator (USO) to conduct a Doppler Wind Experiment (DWE). We also catalog promising technologies currently under development that will strengthen small atmospheric entry probe missions in the future. While SNAP is applicable to multiple planets, we examine the feasibility, benefits and impacts of adding SNAP to the Uranus Orbiter and Probe flagship mission. Our project is supported by NASA PSDS3 grant NNX17AK31G.

Rapid optical imaging of EGF receptor expression with a single-chain antibody SNAP-tag fusion protein.

PubMed

Kampmeier, Florian; Niesen, Judith; Koers, Alexander; Ribbert, Markus; Brecht, Andreas; Fischer, Rainer; Kiessling, Fabian; Barth, Stefan; Thepen, Theo

2010-10-01

The epidermal growth factor receptor (EGFR) is overexpressed in several types of cancer and its inhibition can effectively inhibit tumour progression. The purpose of this study was to design an EGFR-specific imaging probe that combines efficient tumour targeting with rapid systemic clearance to facilitate non-invasive assessment of EGFR expression. Genetic fusion of a single-chain antibody fragment with the SNAP-tag produced a 48-kDa antibody derivative that can be covalently and site-specifically labelled with substrates containing 0 (6)-benzylguanine. The EGFR-specific single-chain variable fragment (scFv) fusion protein 425(scFv)SNAP was labelled with the near infrared (NIR) dye BG-747, and its accumulation, specificity and kinetics were monitored using NIR fluorescence imaging in a subcutaneous pancreatic carcinoma xenograft model. The 425(scFv)SNAP fusion protein accumulates rapidly and specifically at the tumour site. Its small size allows efficient renal clearance and a high tumour to background ratio (TBR) of 33.2 +/- 6.3 (n = 4) 10 h after injection. Binding of the labelled antibody was efficiently competed with a 20-fold excess of unlabelled probe, resulting in an average TBR of 6 +/- 1.35 (n = 4), which is similar to that obtained with a non-tumour-specific probe (5.44 +/- 1.92, n = 4). When compared with a full-length antibody against EGFR (cetuximab), 425(scFv)SNAP-747 showed significantly higher TBRs and complete clearance 72 h post-injection. The 425(scFv)SNAP fusion protein combines rapid and specific targeting of EGFR-positive tumours with a versatile and robust labelling technique that facilitates the attachment of fluorophores for use in optical imaging. The same approach could be used to couple a chelating agent for use in nuclear imaging.

Overview of SNAP

EPA Pesticide Factsheets

Section 612(c) of the Clean Air Act (CAA) requires the Agency to publish a list of acceptable and unacceptable substitutes for ozone-depleting substances (ODS). The SNAP program does not require that substitutes be risk- free to be found acceptable.

7 CFR 1962.45 - Reporting sales.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 14 2010-01-01 2009-01-01 true Reporting sales. 1962.45 Section 1962.45 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... sales. Form FmHA or its successor agency under Public Law 103-354 1955-3, “Advice of Property Acquired...

7 CFR 1962.45 - Reporting sales.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 14 2011-01-01 2011-01-01 false Reporting sales. 1962.45 Section 1962.45 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... sales. Form FmHA or its successor agency under Public Law 103-354 1955-3, “Advice of Property Acquired...

7 CFR 1962.45 - Reporting sales.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 14 2012-01-01 2012-01-01 false Reporting sales. 1962.45 Section 1962.45 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... sales. Form FmHA or its successor agency under Public Law 103-354 1955-3, “Advice of Property Acquired...

7 CFR 1962.45 - Reporting sales.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 14 2014-01-01 2014-01-01 false Reporting sales. 1962.45 Section 1962.45 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... sales. Form FmHA or its successor agency under Public Law 103-354 1955-3, “Advice of Property Acquired...

7 CFR 1962.45 - Reporting sales.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 14 2013-01-01 2013-01-01 false Reporting sales. 1962.45 Section 1962.45 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... sales. Form FmHA or its successor agency under Public Law 103-354 1955-3, “Advice of Property Acquired...

Extending the accuracy of the SNAP interatomic potential form

NASA Astrophysics Data System (ADS)

Wood, Mitchell A.; Thompson, Aidan P.

2018-06-01

The Spectral Neighbor Analysis Potential (SNAP) is a classical interatomic potential that expresses the energy of each atom as a linear function of selected bispectrum components of the neighbor atoms. An extension of the SNAP form is proposed that includes quadratic terms in the bispectrum components. The extension is shown to provide a large increase in accuracy relative to the linear form, while incurring only a modest increase in computational cost. The mathematical structure of the quadratic SNAP form is similar to the embedded atom method (EAM), with the SNAP bispectrum components serving as counterparts to the two-body density functions in EAM. The effectiveness of the new form is demonstrated using an extensive set of training data for tantalum structures. Similar to artificial neural network potentials, the quadratic SNAP form requires substantially more training data in order to prevent overfitting. The quality of this new potential form is measured through a robust cross-validation analysis.

SNAP 10A FS-3 reactor performance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hawley, J.P.; Johnson, R.A.

1966-08-15

SNAP 10FS-3 was the first flight-qualified SNAP reactor system to be operated in a simulated space environment. Prestart-up qualification testing, automatic start-up, endurance period performance, extended operation test and reactor shutdown are described as they affected, or were affected by, overall reactor performance. Performance of the reactor control system and the diagnostic instrumentation is critically evaluted.

A tissue snap-freezing apparatus without sacrificial cryogens

NASA Astrophysics Data System (ADS)

Vanapalli, Srinivas; Jagga, Sahil; Holland, Harry; ter Brake, Marcel

2017-12-01

Molecular technologies in cancer diagnosis require a fresh and frozen tissue, which is obtained by means of snap-freezing. Currently, coolants such as solid carbon dioxide and liquid nitrogen are used to preserve good morphology of the tissue. Using these coolants, snap freezing of tissues for diagnostic and research purposes is often time consuming, laborious, even hazardous and not user friendly. For that reason snap-freezing is not routinely applied at the location of biopsy acquisition. Furthermore, the influence of optimal cooling rate and cold sink temperature on the viability of the cells is not well known. In this paper, a snap-freezing apparatus powered by a small cryocooler is presented that will allow bio-medical research of tissue freezing methods and is safe to use in a hospital. To benchmark this apparatus, cooldown of a standard aluminum cryo-vial in liquid nitrogen is measured and the cooling rate is about -25 K/s between 295 K and 120 K. Sufficient cooling rate is obtained by a forced convective helium gas flow through a gap formed between the cryo-vial and a cold surface and is therefore chosen as the preferred cooling method. A conceptual design of the snap-apparatus with forced flow is discussed in this paper.

In vivo evaluation of radiotracers targeting the melanin-concentrating hormone receptor 1: [11C]SNAP-7941 and [18F]FE@SNAP reveal specific uptake in the ventricular system.

PubMed

Zeilinger, Markus; Dumanic, Monika; Pichler, Florian; Budinsky, Lubos; Wadsak, Wolfgang; Pallitsch, Katharina; Spreitzer, Helmut; Lanzenberger, Rupert; Hacker, Marcus; Mitterhauser, Markus; Philippe, Cécile

2017-08-14

The MCHR1 is involved in the regulation of energy homeostasis and changes of the expression are linked to a variety of associated diseases, such as diabetes and adiposity. The study aimed at the in vitro and in vivo evaluation of [ 11 C]SNAP-7941 and [ 18 F]FE@SNAP as potential PET-tracers for the MCHR1. Competitive binding studies with non-radioactive derivatives and small-animal PET/CT and MRI brain studies were performed under baseline conditions and tracer displacement with the unlabelled MCHR1 antagonist (±)-SNAP-7941. Binding studies evinced high binding affinity of the non-radioactive derivatives. Small-animal imaging of [ 11 C]SNAP-7941 and [ 18 F]FE@SNAP evinced high tracer uptake in MCHR1-rich regions of the ventricular system. Quantitative analysis depicted a significant tracer reduction after displacement with (±)-SNAP-7941. Due to the high binding affinity of the non-labelled derivatives and the high specific tracer uptake of [ 11 C]SNAP-7941 and [ 18 F]FE@SNAP, there is strong evidence that both radiotracers may serve as highly suitable agents for specific MCHR1 imaging.

A document review to characterize Atomic International SNAP fuels shipped to INEL 1966--1973

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wahnschaffe, S.D.; Lords, R.E.; Kneff, D.W.

1995-09-01

This report provides the results of a document search and review study to obtain information on the spent fuels for the following six Nuclear Auxiliary Power (SNAP) reactor cores now stored at the Idaho National Engineering Laboratory (INEL): SNAP-2 Experimental Reactor, SNAP-2 Development Reactor, SNAP-10A Ground Test Reactor, SNAP-8 Experimental Reactor, SNAP-8 Development Reactor, and Shield Test Reactor. The report also covers documentation on SNAP fuel materials from four in-pile materials tests: NAA-82-1, NAA-115-2, NAA-117-1, and NAA-121. Pieces of these fuel materials are also stored at INEL as part of the SNAP fuel shipments.

Poor Dietary Guidelines Compliance among Low-Income Women Eligible for Supplemental Nutrition Assistance Program-Education (SNAP-Ed).

PubMed

Jun, Shinyoung; Thuppal, Sowmyanarayanan V; Maulding, Melissa K; Eicher-Miller, Heather A; Savaiano, Dennis A; Bailey, Regan L

2018-03-08

The Supplemental Nutrition Assistance Program-Education (SNAP-Ed) program aims to improve nutritional intakes of low-income individuals (<185% poverty threshold). The objective of this study was to describe the compliance with Dietary Guidelines for Americans (DGA) recommendations for fruits, vegetables, and whole grains among SNAP-Ed eligible ( n = 3142) and ineligible ( n = 3168) adult women (19-70 years) nationwide and SNAP-Ed participating women in Indiana ( n = 2623), using the NHANES 2007-2012 and Indiana SNAP-Ed survey data, respectively. Sensitivity analysis further stratified women by race/ethnicity and by current SNAP participation (<130% poverty threshold). Nationally, lower-income women were less likely to meet the fruit (21% vs. 25%) and vegetable (11% vs. 19%) guidelines than higher-income women, but did not differ on whole grains, which were ~5% regardless of income. The income differences in fruit and vegetable intakes were driven by non-Hispanic whites. Fewer SNAP-Ed-eligible U.S. women met fruit (21% vs. 55%) and whole grain (4% vs. 18%) but did not differ for vegetable recommendations (11% vs. 9%) when compared to Indiana SNAP-Ed women. This same trend was observed among current SNAP participants. Different racial/ethnic group relationships with DGA compliance were found in Indiana compared to the nation. Nevertheless, most low-income women in the U.S. are at risk of not meeting DGA recommendations for fruits (79%), vegetables (89%), and whole grains (96%); SNAP-Ed participants in Indiana had higher compliance with DGA recommendations. Increased consumption of these three critical food groups would improve nutrient density, likely reduce calorie consumption by replacing high calorie choices, and improve fiber intakes.

Creating Security System Models Using SNAP-PC.

DTIC Science & Technology

1987-05-01

Submodel ATTGRD Prompts ............ 228 x ACKNOWLEDGEMENTS SNAP was originally developed in the late 1970’s by Pritsker & Associates, Inc., for Sandia...systems. The other was to simplify the simulation process so that a person knowledgeable in security planning and who had little experience in ...simulation techniques could use simulation in his evaluation of security systems. SNAP-PC was developed by Pritsker & Associates, Inc., for Sandia with

Enantioselective Synthesis of SNAP-7941

PubMed Central

Goss, Jennifer M.; Schaus, Scott E.

2009-01-01

An enantioselective synthesis of SNAP-7941, a potent melanin concentrating hormone receptor antagonist, was achieved using two organocatalytic methods. The first method utilized to synthesize the enantioenriched dihydropyrimidone core was the Cinchona alkaloid-catalyzed Mannich reaction of β-keto esters to acyl imines and the second was chiral phosphoric acid-catalyzed Biginelli reaction. Completion of the synthesis was accomplished via selective urea formation at the N3 position of the dihydropyrimidone with the 3-(4-phenylpiperidin-1-yl)propyl amine side chain fragment. The synthesis of SNAP-7921 highlights the utility of asymmetric organocatalytic methods in the construction of an important class of chiral heterocycles. PMID:18767801

Expression of the SNARE Protein SNAP-23 Is Essential for Cell Survival

PubMed Central

Kaul, Sunil; Mittal, Sharad K.; Feigenbaum, Lionel; Kruhlak, Michael J.; Roche, Paul A.

2015-01-01

Members of the SNARE-family of proteins are known to be key regulators of the membrane-membrane fusion events required for intracellular membrane traffic. The ubiquitously expressed SNARE protein SNAP-23 regulates a wide variety of exocytosis events and is essential for mouse development. Germline deletion of SNAP-23 results in early embryonic lethality in mice, and for this reason we now describe mice and cell lines in which SNAP-23 can be conditionally-deleted using Cre-lox technology. Deletion of SNAP-23 in CD19-Cre expressing mice prevents B lymphocyte development and deletion of SNAP-23 using a variety of T lymphocyte-specific Cre mice prevents T lymphocyte development. Acute depletion of SNAP-23 in mouse fibroblasts leads to rapid apoptotic cell death. These data highlight the importance of SNAP-23 for cell survival and describe a mouse in which specific cell types can be eliminated by expression of tissue-specific Cre-recombinase. PMID:25706117

Trends in the Supply and Distribution of Physicians in Saskatchewan: January 1962 to June 1964

PubMed Central

Spasoff, Robert; Wolfe, Samuel

1965-01-01

Using all the readily available sources of information, a study was designed to describe the changes in supply and distribution of physicians in Saskatchewan during the inception of the Province's controversial Medical Care Insurance Act. Baselines were obtained in January 1962, and comparisons made in June 1963 and June 1964. The physician:population ratio was 1:1037 in January 1962 and 1:980 in June 1964. The average yearly physician turnover rate of 10% was exceeded in 1960 and in 1961 and then levelled off. The levelling off continued from January 1962 to June 1963. But between June 1963 and June 1964 the total number of physicians was sufficient both to re-establish the rising trend of the previous decade and to offset some of the losses of 1960-1962. PMID:14275041

SNAP Employment and Training: Washington's Basic Food Employment & Training Program (BFET)

ERIC Educational Resources Information Center

Mohan, Lavanya

2014-01-01

SNAP Employment & Training (E&T) is an important component of SNAP (Supplemental Nutrition Assistance Program, formerly known as the Food Stamp Program) that supports a variety of education, training, employment, and related services for SNAP recipients. It gives recipients opportunities to gain skills, training, or experience that will…

SNAP-23 regulates phagosome formation and maturation in macrophages

PubMed Central

Sakurai, Chiye; Hashimoto, Hitoshi; Nakanishi, Hideki; Arai, Seisuke; Wada, Yoh; Sun-Wada, Ge-Hong; Wada, Ikuo; Hatsuzawa, Kiyotaka

2012-01-01

Synaptosomal associated protein of 23 kDa (SNAP-23), a plasma membrane–localized soluble N-ethylmaleimide–sensitive factor attachment protein receptor (SNARE), has been implicated in phagocytosis by macrophages. For elucidation of its precise role in this process, a macrophage line overexpressing monomeric Venus–tagged SNAP-23 was established. These cells showed enhanced Fc receptor–mediated phagocytosis. Detailed analyses of each process of phagocytosis revealed a marked increase in the production of reactive oxygen species within phagosomes. Also, enhanced accumulation of a lysotropic dye, as well as augmented quenching of a pH-sensitive fluorophore were observed. Analyses of isolated phagosomes indicated the critical role of SNAP-23 in the functional recruitment of the NADPH oxidase complex and vacuolar-type H+-ATPase to phagosomes. The data from the overexpression experiments were confirmed by SNAP-23 knockdown, which demonstrated a significant delay in phagosome maturation and a reduction in uptake activity. Finally, for analyzing whether phagosomal SNAP-23 entails a structural change in the protein, an intramolecular Förster resonance energy transfer (FRET) probe was constructed, in which the distance within a TagGFP2-TagRFP was altered upon close approximation of the N-termini of its two SNARE motifs. FRET efficiency on phagosomes was markedly enhanced only when VAMP7, a lysosomal SNARE, was coexpressed. Taken together, our results strongly suggest the involvement of SNAP-23 in both phagosome formation and maturation in macrophages, presumably by mediating SNARE-based membrane traffic. PMID:23087210

Fast simultaneous noncontrast angiography and intraplaque hemorrhage (fSNAP) sequence for carotid artery imaging.

PubMed

Chen, Shuo; Ning, Jia; Zhao, Xihai; Wang, Jinnan; Zhou, Zechen; Yuan, Chun; Chen, Huijun

2017-02-01

To propose a fast simultaneous noncontrast angiography and intraplaque hemorrhage (fSNAP) sequence for carotid artery imaging. The proposed fSNAP sequence uses a low-resolution reference acquisition for phase-sensitive reconstruction to speed up the scan, and an inversion recovery acquisition with arbitrary k-space filling order to generate similar contrast to conventional SNAP. Four healthy volunteers and eight patients were recruited to test the performance of fSNAP in vivo. The lumen area quantification, muscle-blood CNR, IPH-blood CNR, lumen SNR, and standard deviation and intraplaque hemorrhage (IPH) detection accuracy were compared between fSNAP and SNAP. By using a low-resolution reference acquisition with 1/4 matrix size of the full-resolution reference scan, the scan time of fSNAP was 37.5% less than that of SNAP. A high agreement of lumen area measurement (ICC = 0.97, 95% CI: 0.96-0.99) and IPH detection (Kappa = 1) were found between fSNAP and SNAP. Also, no significant difference was found for muscle-blood CNR (P = 0.25), IPH-blood CNR (P = 0.35), lumen SNR (P = 0.60), and standard deviation (P = 0.46) between the two techniques. The feasibility of fSNAP was validated. fSNAP can improve the imaging efficiency with similar performance to SNAP on carotid artery imaging. Magn Reson Med 77:753-758, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

Associations of cooking with dietary intake and obesity among SNAP participants

PubMed Central

Taillie, Lindsey Smith; Poti, Jennifer M.

2017-01-01

Introduction Participation in the Supplemental Nutrition Assistance Program (SNAP) may help ease economic and time constraints of cooking, helping low-income households prepare healthier meals. As a result, frequent cooking may be more strongly associated with improved dietary outcomes among SNAP recipients than among income-eligible non-SNAP-recipients. Alternately, increased frequency of home-cooked meals among SNAP participants may be beneficial simply by replacing fast food intake. The objective is to quantify the association between home cooking and fast food with diet intake and weight status among SNAP recipients. Methods 2015 data from low-income adults aged 19-65y from the National Health and Nutrition Survey, 2007-2010 (n=2,578) was used to examine associations between daily home-cooked dinner and weekly fast food intake with diet intake, including calories from solid fat and added sugar, key food groups (sugar-sweetened beverages (SSBs), fruit, and vegetables), and prevalence of overweight/obesity. Differences in these association for SNAP recipients vs. income-eligible non-recipients were analyzed, as well as whether associations were attenuated when controlling for fast food intake. Results Daily home-cooked dinners were associated with small improvements in dietary intake for SNAP recipients but not for non-recipients, including lower SSB intake (-54 kcal/day), and reduced prevalence of overweight/obesity (-6%) (p<0.05). However, these associations were attenuated after controlling for fast food intake. Consuming one fast food meal/week was associated with 9.3% and 11.6% higher overweight/obesity prevalence among SNAP recipients and non-recipients, respectively (p<0.05). Conclusion Strategies to improve dietary intake among SNAP recipients should consider both increasing home cooking and reducing fast food intake. PMID:28109417

The Schedule for Nonadaptive and Adaptive Personality for Youth (SNAP-Y): a new measure for assessing adolescent personality and personality pathology.

PubMed

Linde, Jennifer A; Stringer, Deborah; Simms, Leonard J; Clark, Lee Anna

2013-08-01

The Schedule for Nonadaptive and Adaptive Personality-Youth Version (SNAP-Y) is a new, reliable self-report questionnaire that assesses 15 personality traits relevant to both normal-range personality and the alternative DSM-5 model for personality disorder. Community adolescents, 12 to 18 years old (N = 364), completed the SNAP-Y; 347 also completed the Big Five Inventory-Adolescent, 144 provided 2-week retest data, and 128 others completed the Minnesota Multiphasic Personality Inventory-Adolescent. Outpatient adolescents (N = 103) completed the SNAP-Y, and 97 also completed the Minnesota Multiphasic Personality Inventory-Adolescent. The SNAP-Y demonstrated strong psychometric properties, and structural, convergent, discriminant, and external validities. Consistent with the continuity of personality, results paralleled those in adult and college samples using the adult Schedule for Nonadaptive and Adaptive Personality-Second Edition (SNAP-2), from which the SNAP-Y derives and which has established validity in personality-trait assessment across the normal-abnormal continuum. The SNAP-Y thus provides a new, clinically useful instrument to assess personality traits and personality pathology in adolescents.

Territorial aggressiveness and predation: two possible origins of snapping in the ant Plectroctena minor.

PubMed

Dejean, Alain; Suzzoni, Jean-Pierre; Schatz, Bertrand; Orivel, Jérôme

2002-07-01

Plectroctena minor workers have long mandibles that can snap and deliver a sharp blow to intruders or prey, stunning or killing them. Encounters between homocolonial P. minor workers separated for 24 h or 15 days never resulted in snapping, while this behaviour was always noted during encounters between heterocolonial workers on neutral arenas or on the territory of a colony. In the latter case, only the aliens, that generally tried to escape, were snapped at. Snapping also occurred during encounters with workers belonging to sympatric ponerine species. During predation, the percentages of snapping varied according to prey nature, suggesting prey discrimination. Termite soldiers were always snapped at, while other prey were more often snapped close to rather than far from the nest entrances, indicating an intermingling of territorial aggressiveness and predatory behaviour. We discuss the adaptive value of snapping for hunting in galleries.

22 CFR 196.2 - How is the Fellowship Program administered?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false How is the Fellowship Program administered? 196.2 Section 196.2 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL COMMERCIAL ARBITRATION THOMAS R. PICKERING FOREIGN AFFAIRS/GRADUATE FOREIGN AFFAIRS FELLOWSHIP PROGRAM § 196.2 How is the Fellowship Program...

22 CFR 196.2 - How is the Fellowship Program administered?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false How is the Fellowship Program administered? 196.2 Section 196.2 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL COMMERCIAL ARBITRATION THOMAS R. PICKERING FOREIGN AFFAIRS/GRADUATE FOREIGN AFFAIRS FELLOWSHIP PROGRAM § 196.2 How is the Fellowship Program...

22 CFR 196.2 - How is the Fellowship Program administered?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false How is the Fellowship Program administered? 196.2 Section 196.2 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL COMMERCIAL ARBITRATION THOMAS R. PICKERING FOREIGN AFFAIRS/GRADUATE FOREIGN AFFAIRS FELLOWSHIP PROGRAM § 196.2 How is the Fellowship Program...

22 CFR 196.2 - How is the Fellowship Program administered?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false How is the Fellowship Program administered? 196.2 Section 196.2 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL COMMERCIAL ARBITRATION THOMAS R. PICKERING FOREIGN AFFAIRS/GRADUATE FOREIGN AFFAIRS FELLOWSHIP PROGRAM § 196.2 How is the Fellowship Program...

22 CFR 196.2 - How is the Fellowship Program administered?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false How is the Fellowship Program administered? 196.2 Section 196.2 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL COMMERCIAL ARBITRATION THOMAS R. PICKERING FOREIGN AFFAIRS/GRADUATE FOREIGN AFFAIRS FELLOWSHIP PROGRAM § 196.2 How is the Fellowship Program...

A Reliability Improvement Program Planning Report for the SNAP 10A Space Nuclear Power Unit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coombs, M. G.; Smith, C. K.; Wilson, L. A.

1961-03-14

The estimated achieved reliability of SNAP 10A space nuclear power units will be relatively low at the timeof the first SNAPSHOT flight test in April 1963 and the existing R&D program does not provide a significant reliabiity growth thereafter. The total costs of an 8-satellite network using SNAP 10A units over a 5-year period has been approximated for the case where the total cost of a single satellite launched is 8 million dollars.

United States Air Force Statistical Digest, Fiscal Year 1962, Seventeenth Edition

DTIC Science & Technology

1962-09-30

belOW’Is a revision of ’lable 44, FY 1961 GAINS Not Beyond Eco From TYPE, M:lDEL, AND SERIES Pro- MAP, From Redes - Com-Total due- USA, Other i_- Total... Redes - mer- ebec- Recla-tion and t10n i_- cia! lete ma- USN tion Sale t10n ..FIR8l’ ’HALF FY 1962 (1 July W& . . ill 446 18 20 ~ 1,451 281 8 1 .21...LOSSES BY TV e; --- GAINS 110’ .7ŕ’" Eco From TYPE, MODEL, ANDSERlES; Pro- MAP, From Redes - Com- Total duc- USA, other tgne- Total Redes - A>_ Hecla.t10n

7 CFR 1962.7 - Securing unpaid balances on unsecured loans.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 14 2010-01-01 2009-01-01 true Securing unpaid balances on unsecured loans. 1962.7 Section 1962.7 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE... Security § 1962.7 Securing unpaid balances on unsecured loans. The County Supervisor will take a lien on a...

7 CFR 1962.7 - Securing unpaid balances on unsecured loans.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 14 2011-01-01 2011-01-01 false Securing unpaid balances on unsecured loans. 1962.7 Section 1962.7 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE... Security § 1962.7 Securing unpaid balances on unsecured loans. The County Supervisor will take a lien on a...

Triggered Snap-Through of Bistable Shells

NASA Astrophysics Data System (ADS)

Cai, Yijie; Huang, Shicheng; Trase, Ian; Hu, Nan; Chen, Zi

Elastic bistable shells are common structures in nature and engineering, such as the lobes of the Venus flytrap or the surface of a toy jumping poppers. Despite their ubiquity, the parameters that control the bistability of such structures are not well understood. In this study, we explore how the geometrical features of radially symmetric elastic shells affect the shape and potential energy of a shell's stable states, and how to tune certain parameters in order to generate a snap-through transition from a convex semi-stable state to concave stable state. We fabricated a series of elastic shells with varying geometric parameters out of silicone rubber and measured the resulting potential energy in the semi-stable state. Finite element simulations were also conducted in order to determine the deformation and stress in the shells during snap-through. It was found that the energy of the semi-stable state is controlled by only two geometric parameters and a dimensionless ratio. We also noted two distinct transitions during snap-through, one between monostability and semi-bistability (the state a popper toy is in before it snaps-through and jumps), and a second transition between semi-bistability and true bistability. This work shows that it is possible to use a set of simple parameters to tailor the energy landscape of an elastic shell in order to generate complex trigger motions for their potential use in smart applications. Z.C. acknowledge support from Society in Science-Branco Weiss Fellowship, administered by ETH Zurich.

The effectiveness of the Stop Now and Plan (SNAP) program for boys at risk for violence and delinquency.

PubMed

Burke, Jeffrey D; Loeber, Rolf

2015-02-01

Among the available treatments for disruptive behavior problems, a need remains for additional service options to reduce antisocial behavior and prevent further development along delinquent and violent pathways. The Stop Now and Plan (SNAP) Program is an intervention for antisocial behavior among boys between 6 and 11. This paper describes a randomized controlled treatment effectiveness study of SNAP versus standard behavioral health services. The treatment program was delivered to youth with aggressive, rule-breaking, or antisocial behavior in excess of clinical criterion levels. Outcomes were measured at 3, 9, and 15 months from baseline. Youth in the SNAP condition showed significantly greater reduction in aggression, conduct problems, and overall externalizing behavior, as well as counts of oppositional defiant disorder and attention deficit hyperactivity disorder symptoms. Additional benefits for SNAP were observed on measures of depression and anxiety. Further analyses indicated that the SNAP program was more effective among those with a higher severity of initial behavioral problems. At 1 year follow-up, treatment benefits for SNAP were maintained on some outcome measures (aggression, ADHD and ODD, depression and anxiety) but not others. Although overall juvenile justice system contact was not significantly different, youth in SNAP had significantly fewer charges against them relative to those standard services. The SNAP Program, when contrasted with standard services alone, was associated with greater, clinically meaningful, reductions in targeted behaviors. It may be particularly effective for youth with more severe behavioral problems and may result in improvements in internalizing problems as well.

Phosphorylation of SNAP-23 regulates its dynamic membrane association during mast cell exocytosis

PubMed Central

Naskar, Pieu

2017-01-01

ABSTRACT Upon allergen challenge, mast cells (MCs) respond by releasing pre-stored mediators from their secretory granules by the transient mechanism of porosome-mediated cell secretion. The target SNARE SNAP-23 has been shown to be important for MC exocytosis, and our previous studies revealed the presence of one basal (Thr102) and two induced (Ser95 and Ser120) phosphorylation sites in its linker region. To study the role of SNAP-23 phosphorylation in the regulation of exocytosis, green fluorescence protein-tagged wild-type SNAP-23 (GFP-SNAP-23) and its phosphorylation mutants were transfected into rat basophilic leukemia (RBL-2H3) MCs. Studies on GFP-SNAP-23 transfected MCs revealed some dynamic changes in SNAP-23 membrane association. SNAP-23 was associated with plasma membrane in resting MCs, however, on activation a portion of it translocated to cytosol and internal membranes. These internal locations were secretory granule membranes. This dynamic change in the membrane association of SNAP-23 in MCs may be important for mediating internal granule-granule fusions in compound exocytosis. Further studies with SNAP-23 phosphorylation mutants revealed an important role for the phosphorylation at Thr102 in its initial membrane association, and of induced phosphorylation at Ser95 and Ser120 in its internal membrane association, during MC exocytosis. PMID:28784843

Phosphorylation of SNAP-23 regulates its dynamic membrane association during mast cell exocytosis.

PubMed

Naskar, Pieu; Puri, Niti

2017-09-15

Upon allergen challenge, mast cells (MCs) respond by releasing pre-stored mediators from their secretory granules by the transient mechanism of porosome-mediated cell secretion. The target SNARE SNAP-23 has been shown to be important for MC exocytosis, and our previous studies revealed the presence of one basal (Thr 102 ) and two induced (Ser 95 and Ser 120 ) phosphorylation sites in its linker region. To study the role of SNAP-23 phosphorylation in the regulation of exocytosis, green fluorescence protein-tagged wild-type SNAP-23 (GFP-SNAP-23) and its phosphorylation mutants were transfected into rat basophilic leukemia (RBL-2H3) MCs. Studies on GFP-SNAP-23 transfected MCs revealed some dynamic changes in SNAP-23 membrane association. SNAP-23 was associated with plasma membrane in resting MCs, however, on activation a portion of it translocated to cytosol and internal membranes. These internal locations were secretory granule membranes. This dynamic change in the membrane association of SNAP-23 in MCs may be important for mediating internal granule-granule fusions in compound exocytosis. Further studies with SNAP-23 phosphorylation mutants revealed an important role for the phosphorylation at Thr 102 in its initial membrane association, and of induced phosphorylation at Ser 95 and Ser 120 in its internal membrane association, during MC exocytosis. © 2017. Published by The Company of Biologists Ltd.

Botulinum neurotoxin type A: Actions beyond SNAP-25?

PubMed

Matak, Ivica; Lacković, Zdravko

2015-09-01

Botulinum neurotoxin type A (BoNT/A), the most potent toxin known in nature which causes botulism, is a commonly used therapeutic protein. It prevents synaptic vesicle neuroexocytosis by proteolytic cleavage of synaptosomal-associated protein of 25 kDa (SNAP-25). It is widely believed that BoNT/A therapeutic or toxic actions are exclusively mediated by SNAP-25 cleavage. On the other hand, in vitro and in vivo findings suggest that several BoNT/A actions related to neuroexocytosis, cell cycle and apoptosis, neuritogenesis and gene expression are not necessarily mediated by this widely accepted mechanism of action. In present review we summarize the literature evidence which point to the existence of unknown BoNT/A molecular target(s) and modulation of unknown signaling pathways. The effects of BoNT/A apparently independent of SNAP-25 occur at similar doses/concentrations known to induce SNAP-25 cleavage and prevention of neurotransmitter release. Accordingly, these effects might be pharmacologically significant. Potentially the most interesting are observations of antimitotic and antitumor activity of BoNT/A. However, the exact mechanisms require further studies. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

The Classroom Animal: Snapping Turtles.

ERIC Educational Resources Information Center

Kramer, David C.

1987-01-01

Describes the distinctive features of the common snapping turtle. Discusses facts and misconceptions held about the turtle. Provides guidelines for proper care and treatment of a young snapper in a classroom environment. (ML)

A VESICLE TRAFFICKING PROTEIN αSNAP REGULATES PANETH CELL DIFFERENTIATION IN VIVO

PubMed Central

Lechuga, Susana; Naydenov, Nayden G.; Feygin, Alex; Jimenez, Antonio J.; Ivanov, Andrei I.

2017-01-01

A soluble N-ethylmaleimide-sensitive factor-attachment protein alpha (αSNAP) is a multifunctional scaffolding protein that regulates intracellular vesicle trafficking and signaling. In cultured intestinal epithelial cells, αSNAP has been shown to be essential for cell survival, motility, and adhesion; however, its physiologic functions in the intestinal mucosa remain unknown. In the present study, we used a mouse with a spontaneous hydrocephalus with hop gait (hyh) mutation of αSNAP to examine the roles of this trafficking protein in regulating intestinal epithelial homeostasis in vivo. Homozygous hyh mice demonstrated decreased expression of αSNAP protein in the intestinal epithelium, but did not display gross abnormalities of epithelial architecture in the colon and ileum. Such αSNAP depletion attenuated differentiation of small intestinal epithelial enteroids ex vivo. Furthermore, αSNAP-deficient mutant animals displayed reduced formation of lysozyme granules in small intestinal crypts and decreased expression of lysozyme and defensins in the intestinal mucosa, which is indicative of defects in Paneth cell differentiation. By contrast, development of Goblet cells, enteroendocrine cells, and assembly of enterocyte apical junctions was not altered in hyh mutant mice. Our data revealed a novel role of αSNAP in the intestinal Paneth cell differentiation in vivo. PMID:28359759

Fluorescent labeling of SNAP-tagged proteins in cells.

PubMed

Lukinavičius, Gražvydas; Reymond, Luc; Johnsson, Kai

2015-01-01

One of the most prominent self-labeling tags is SNAP-tag. It is an in vitro evolution product of the human DNA repair protein O (6)-alkylguanine-DNA alkyltransferase (hAGT) that reacts specifically with benzylguanine (BG) and benzylchloropyrimidine (CP) derivatives, leading to covalent labeling of SNAP-tag with a synthetic probe (Gronemeyer et al., Protein Eng Des Sel 19:309-316, 2006; Curr Opin Biotechnol 16:453-458, 2005; Keppler et al., Nat Biotechnol 21:86-89, 2003; Proc Natl Acad Sci U S A 101:9955-9959, 2004). SNAP-tag is well suited for the analysis and quantification of fused target protein using fluorescence microscopy techniques. It provides a simple, robust, and versatile approach to the imaging of fusion proteins under a wide range of experimental conditions.

Snap-in of particles at curved liquid interfaces

NASA Astrophysics Data System (ADS)

Li, Chao; Moradiafrapoli, Momene; Marston, Jeremy

2016-11-01

The contact of particles with liquid interfaces constitutes the first stage in the formation of a particle-laden interface, the so-called "snap-in effect". Here, we report on an experimental study using high-speed video to directly visualize the snap-in process and the approach to the equilibrium state of a particle at a curved liquid interface (i.e. droplet surface). We image the evolution of the contact line, which is found to follow a power-law scaling in time, and the dynamic contact angle during the snap-in. Both hydrophilic and hydrophobic particles are explored and we match the lift-off stage of the particles with a simple force balance. We also explore some multi-particle experiments, eluding to the dynamics of particle-laden interface formation.

Snap-through twinkling energy generation through frequency up-conversion

NASA Astrophysics Data System (ADS)

Panigrahi, Smruti R.; Bernard, Brian P.; Feeny, Brian F.; Mann, Brian P.; Diaz, Alejandro R.

2017-07-01

A novel experimental energy harvester is investigated for its energy harvesting capability by frequency up-conversion using snap-through structures. In particular, a single-degree-of-freedom (SDOF) experimental energy harvester model is built using a snap-through nonlinear element. The snap-through dynamics is facilitated by the experimental setup of a twinkling energy generator (TEG) consisting of linear springs and attracting cylindrical bar magnets. A cylindrical coil of enamel-coated magnet wire is used as the energy generator. The governing equations are formulated mathematically and solved numerically for a direct comparison with the experimental results. The experimental TEG and the numerical simulation results show 25-fold frequency up-conversion and the power harvesting capacity of the SDOF TEG.

76 FR 27603 - Supplemental Nutrition Assistance Program: Civil Rights Protections for SNAP Households

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-12

...,'' to identify and address any major civil rights impacts the rule might have on minorities, women, and... Nutrition Assistance Program: Civil Rights Protections for SNAP Households AGENCY: Food and Nutrition... Nutrition Assistance Program (SNAP) regulations that secure civil rights protections for SNAP households and...

Distal triceps injuries (including snapping triceps): A systematic review of the literature.

PubMed

Shuttlewood, Kimberley; Beazley, James; Smith, Christopher D

2017-06-18

To review current literature on types of distal triceps injury and determine diagnosis and appropriate management. We performed a systematic review in PubMed, Cochrane and EMBASE using the terms distal triceps tears and snapping triceps on the 10 th January 2017. We excluded all animal, review, foreign language and repeat papers. We reviewed all papers for relevance and of the papers left we were able to establish the types of distal triceps injury, how these injuries are diagnosed and investigated and the types of management of these injuries including surgical. The results are then presented in a review paper format. Three hundred and seventy-nine papers were identified of which 65 were relevant to distal triceps injuries. After exclusion we had 47 appropriate papers. The papers highlighted 2 main distal triceps injuries: Distal triceps tears and snapping triceps. Triceps tear are more common in males than females occurring in the 4 th -5 th decade of life and often due to a direct trauma but are also strongly associated with weightlifting and American football. The tears are diagnosed by history and clinically with a palpable gap. Diagnosis can be confirmed with the use of ultrasound (US) and magnetic resonance imaging. Treatment depends on type of tear. Partial tears can be treated conservatively with bracing and physio whereas acute tears need repair either open or arthroscopic using suture anchor or bone tunnel techniques with similar success. Chronic tears often need augmenting with tendon allograft or autograft. Snapping triceps are also seen more in men than women but at a mean age of 32 years. They are characterized by a snapping sensation mostly medially and can be associated with ulna nerve subluxation and ulna nerve symptoms. US is the diagnostic modality of choice due to its dynamic nature and to differentiate between snapping triceps tendon or ulna nerve. Treatment is conservative initially with activity avoidance and if that fails surgical

Distal triceps injuries (including snapping triceps): A systematic review of the literature

PubMed Central

Shuttlewood, Kimberley; Beazley, James; Smith, Christopher D

2017-01-01

AIM To review current literature on types of distal triceps injury and determine diagnosis and appropriate management. METHODS We performed a systematic review in PubMed, Cochrane and EMBASE using the terms distal triceps tears and snapping triceps on the 10th January 2017. We excluded all animal, review, foreign language and repeat papers. We reviewed all papers for relevance and of the papers left we were able to establish the types of distal triceps injury, how these injuries are diagnosed and investigated and the types of management of these injuries including surgical. The results are then presented in a review paper format. RESULTS Three hundred and seventy-nine papers were identified of which 65 were relevant to distal triceps injuries. After exclusion we had 47 appropriate papers. The papers highlighted 2 main distal triceps injuries: Distal triceps tears and snapping triceps. Triceps tear are more common in males than females occurring in the 4th-5th decade of life and often due to a direct trauma but are also strongly associated with weightlifting and American football. The tears are diagnosed by history and clinically with a palpable gap. Diagnosis can be confirmed with the use of ultrasound (US) and magnetic resonance imaging. Treatment depends on type of tear. Partial tears can be treated conservatively with bracing and physio whereas acute tears need repair either open or arthroscopic using suture anchor or bone tunnel techniques with similar success. Chronic tears often need augmenting with tendon allograft or autograft. Snapping triceps are also seen more in men than women but at a mean age of 32 years. They are characterized by a snapping sensation mostly medially and can be associated with ulna nerve subluxation and ulna nerve symptoms. US is the diagnostic modality of choice due to its dynamic nature and to differentiate between snapping triceps tendon or ulna nerve. Treatment is conservative initially with activity avoidance and if that fails

Fluorescent Labeling of COS-7 Expressing SNAP-tag Fusion Proteins for Live Cell Imaging

PubMed Central

Provost, Christopher R.; Sun, Luo

2010-01-01

SNAP-tag and CLIP-tag protein labeling systems enable the specific, covalent attachment of molecules, including fluorescent dyes, to a protein of interest in live cells. These systems offer a broad selection of fluorescent substrates optimized for a range of imaging instrumentation. Once cloned and expressed, the tagged protein can be used with a variety of substrates for numerous downstream applications without having to clone again. There are two steps to using this system: cloning and expression of the protein of interest as a SNAP-tag fusion, and labeling of the fusion with the SNAP-tag substrate of choice. The SNAP-tag is a small protein based on human O6-alkylguanine-DNA-alkyltransferase (hAGT), a DNA repair protein. SNAP-tag labels are dyes conjugated to guanine or chloropyrimidine leaving groups via a benzyl linker. In the labeling reaction, the substituted benzyl group of the substrate is covalently attached to the SNAP-tag. CLIP-tag is a modified version of SNAP-tag, engineered to react with benzylcytosine rather than benzylguanine derivatives. When used in conjunction with SNAP-tag, CLIP-tag enables the orthogonal and complementary labeling of two proteins simultaneously in the same cells. PMID:20485262

Cutaneous fibroma in a captive common snapping turtle (Chelydra serpentina).

PubMed

Gonzales-Viera, O; Bauer, G; Bauer, A; Aguiar, L S; Brito, L T; Catão-Dias, J L

2012-11-01

An adult female common snapping turtle (Chelydra serpentina) had a mass on the plantar surface of the right forelimb that was removed surgically. Microscopical examination revealed many spindle cells with mild anisocytosis and anisokaryosis and a surrounding collagenous stroma. There were no mitoses. Immunohistochemistry showed that the spindle cells expressed vimentin, but not desmin. A diagnosis of cutaneous fibroma was made. Tumours are reported uncommonly in chelonian species. Cutaneous fibroma has been diagnosed in an alligator snapping turtle (Macrochelys temminckii), but not previously in a common snapping turtle. Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.

78 FR 11967 - Supplemental Nutrition Assistance Program (SNAP): Updated Trafficking Definition and Supplemental...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-21

... disqualification of a SNAP client who intentionally obtains cash by purchasing, with SNAP benefits, products that... exchange for cash refund of deposit(s); or who intentionally resells or exchanges products purchased with... the SNAP client. Examples of the latter would be the purchase, by retailers, of products originally...

Gasket and snap ring installation tool

DOEpatents

Southerland, Jr., James M.; Barringer, Jr., Curtis N.

1994-01-01

A tool for installing a gasket and a snap ring including a shaft, a first plate attached to the forward end of the shaft, a second plate slidably carried by the shaft, a spring disposed about the shaft between the first and second plates, and a sleeve that is free to slide over the shaft and engage the second plate. The first plate has a loading surface with a loading groove for receiving a snap ring and a shoulder for holding a gasket. A plurality of openings are formed through the first plate, communicating with the loading groove and approximately equally spaced about the groove. A plurality of rods are attached to the second plate, each rod slidable in one of the openings. In use, the loaded tool is inserted into a hollow pipe or pipe fitting having an internal flange and an internal seating groove, such that the gasket is positioned against the flange and the ring is in the approximate plane of the seating groove. The sleeve is pushed against the second plate, sliding the second plate towards the first plate, compressing the spring and sliding the rods forwards in the openings. The rods engage the snap ring and urge the ring from the loading groove into the seating groove.

THE EFFECTS OF OXIDANT AIR POLLUTANTS ON SOYBEANS, SNAP BEANS AND POTATOES

EPA Science Inventory

During the past 5 years the impact of photochemical oxidants on soybeans and snap beans in Maryland and on potatoes in Virginia and Delaware was assessed with open-top chambers. The mean yields of four selected soybean varieties grown in open-top chambers with carbon-filtered air...

Impact and ethics of excluding sweetened beverages from the SNAP program.

PubMed

Barnhill, Anne

2011-11-01

The state of New York recently petitioned the US Department of Agriculture (USDA) for permission to conduct a demonstration project in which sweetened beverages would be excluded from the foods eligible to be purchased with Supplemental Assistance Nutrition Program (SNAP) benefits (i.e., food stamps) in New York City. The USDA and advocacy groups have raised objections to new SNAP restrictions such as the proposed exclusion of sweetened beverages. Some objections rest on empirical issues best resolved by demonstration projects or pilot studies of new exclusions. Other objections question the equity of excluding sweetened beverages from SNAP; these objections are important but not ethically decisive. The USDA should approve the proposed demonstration project and should encourage other pilot studies to assess the effects of excluding sweetened beverages from SNAP.

Impact and Ethics of Excluding Sweetened Beverages From the SNAP Program

PubMed Central

2011-01-01

The state of New York recently petitioned the US Department of Agriculture (USDA) for permission to conduct a demonstration project in which sweetened beverages would be excluded from the foods eligible to be purchased with Supplemental Assistance Nutrition Program (SNAP) benefits (i.e., food stamps) in New York City. The USDA and advocacy groups have raised objections to new SNAP restrictions such as the proposed exclusion of sweetened beverages. Some objections rest on empirical issues best resolved by demonstration projects or pilot studies of new exclusions. Other objections question the equity of excluding sweetened beverages from SNAP; these objections are important but not ethically decisive. The USDA should approve the proposed demonstration project and should encourage other pilot studies to assess the effects of excluding sweetened beverages from SNAP. PMID:21566025

SNAP-25 in hippocampal CA3 region is required for long-term memory formation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hou Qiuling; Gao Xiang; Lu Qi

SNAP-25 is a synaptosomal protein of 25 kDa, a key component of synaptic vesicle-docking/fusion machinery, and plays a critical role in exocytosis and neurotransmitter release. We previously reported that SNAP-25 in the hippocampal CA1 region is involved in consolidation of contextual fear memory and water-maze spatial memory (Hou et al. European J Neuroscience, 20: 1593-1603, 2004). SNAP-25 is expressed not only in the CA1 region, but also in the CA3 region, and the SNAP-25 mRNA level in the CA3 region is higher than in the CA1 region. Here, we provide evidence that SNAP-25 in the CA3 region is also involvedmore » in learning/memory. Intra-CA3 infusion of SNAP-25 antisense oligonucleotide impaired both long-term contextual fear memory and water-maze spatial memory, with short-term memory intact. Furthermore, the SNAP-25 antisense oligonucleotide suppressed the long-term potentiation (LTP) of field excitatory post-synaptic potential (fEPSP) in the mossy-fiber pathway (DG-CA3 pathway), with no effect on paired-pulse facilitation of the fEPSP. These results are consistent with the notion that SNAP-25 in the hippocampal CA3 region is required for long-term memory formation.« less

Ending SNAP subsidies for sugar-sweetened beverages could reduce obesity and type 2 diabetes.

PubMed

Basu, Sanjay; Seligman, Hilary Kessler; Gardner, Christopher; Bhattacharya, Jay

2014-06-01

To reduce obesity and type 2 diabetes rates, lawmakers have proposed modifying Supplemental Nutrition Assistance Program (SNAP) benefits to encourage healthier food choices. We examined the impact of two proposed policies: a ban on using SNAP dollars to buy sugar-sweetened beverages; and a subsidy in which for every SNAP dollar spent on fruit and vegetables, thirty cents is credited back to participants' SNAP benefit cards. We used nationally representative data and models describing obesity, type 2 diabetes, and determinants of food consumption among a sample of over 19,000 SNAP participants. We found that a ban on SNAP purchases of sugar-sweetened beverages would be expected to significantly reduce obesity prevalence and type 2 diabetes incidence, particularly among adults ages 18-65 and some racial and ethnic minorities. The subsidy policy would not be expected to have a significant effect on obesity and type 2 diabetes, given available data. Such a subsidy could, however, more than double the proportion of SNAP participants who meet federal vegetable and fruit consumption guidelines. Project HOPE—The People-to-People Health Foundation, Inc.

A vesicle trafficking protein αSNAP regulates Paneth cell differentiation in vivo.

PubMed

Lechuga, Susana; Naydenov, Nayden G; Feygin, Alex; Jimenez, Antonio J; Ivanov, Andrei I

2017-05-13

A soluble N-ethylmaleimide-sensitive factor-attachment protein alpha (αSNAP) is a multifunctional scaffolding protein that regulates intracellular vesicle trafficking and signaling. In cultured intestinal epithelial cells, αSNAP has been shown to be essential for cell survival, motility, and adhesion; however, its physiologic functions in the intestinal mucosa remain unknown. In the present study, we used a mouse with a spontaneous hydrocephalus with hop gait (hyh) mutation of αSNAP to examine the roles of this trafficking protein in regulating intestinal epithelial homeostasis in vivo. Homozygous hyh mice demonstrated decreased expression of αSNAP protein in the intestinal epithelium, but did not display gross abnormalities of epithelial architecture in the colon and ileum. Such αSNAP depletion attenuated differentiation of small intestinal epithelial enteroids ex vivo. Furthermore, αSNAP-deficient mutant animals displayed reduced formation of lysozyme granules in small intestinal crypts and decreased expression of lysozyme and defensins in the intestinal mucosa, which is indicative of defects in Paneth cell differentiation. By contrast, development of Goblet cells, enteroendocrine cells, and assembly of enterocyte apical junctions was not altered in hyh mutant mice. Our data revealed a novel role of αSNAP in the intestinal Paneth cell differentiation in vivo. Copyright © 2017 Elsevier Inc. All rights reserved.

The Schedule for Nonadaptive and Adaptive Personality for Youth (SNAP-Y): A New Measure for Assessing Adolescent Personality and Personality Pathology

ERIC Educational Resources Information Center

Linde, Jennifer A.; Stringer, Deborah; Simms, Leonard J.; Clark, Lee Anna

2013-01-01

The Schedule for Nonadaptive and Adaptive Personality-Youth Version (SNAP-Y) is a new, reliable self-report questionnaire that assesses 15 personality traits relevant to both normal-range personality and the alternative "DSM"-5 model for personality disorder. Community adolescents, 12 to 18 years old (N = 364), completed the SNAP-Y; 347…

Examining Internet Access and Social Media Application Use for Online Nutrition Education in SNAP-Ed Participants in Rural Illinois.

PubMed

Loehmer, Emily; Smith, Sylvia; McCaffrey, Jennifer; Davis, Jeremy

2018-01-01

To examine Internet access and interest in receiving nutrition education via social media applications among low-income adults participating in the Supplemental Nutrition Assistance Program Education (SNAP-Ed). A cross-sectional survey was distributed during 25 SNAP-Ed classes throughout the 16 southernmost counties of Illinois. From 188 responses, the majority of participants had Internet access (76%). Among participants aged 18-32 years (n = 51), 92% owned a smartphone with Internet access and 57% indicated that they would use online nutrition education, with most interest in e-mail (41%), Facebook (40%), and text messaging (35%). There was little interest in using blogs, Vine, Twitter, Tumblr, and Pinterest. Overall, 49% of middle-aged adults aged 33-64 years and 87% of seniors aged ≥65 years reported they would not use online nutrition education. Results indicated similar Internet accessibility in southern Illinois among low-income populations compared with national rural rates. Interest in using online nutrition education varied among SNAP-Ed participants according to age. Young adults appeared to be the most captive audience regarding online nutrition education. Results may be useful to agencies implementing SNAP-Ed to supplement current curriculum with online nutrition education for audiences aged ≤32 years. Copyright © 2017 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

Common snapping turtle preys on an adult western grebe

USGS Publications Warehouse

Igl, L.D.; Peterson, S.L.

2010-01-01

The identification of predators of aquatic birds can be difficult. The Common Snapping Turtle (Chelydra serpentine) is considered a major predator of waterfowl and other aquatic birds, but the evidence for this reputation is based largely on circumstantial or indirect evidence rather than direct observations. Herein, the first documented observations of a snapping turtle attacking and killing an adult Western Grebe (Aechmophorus occidentalis) are described.

Taking Lessons Learned from a Proxy Application to a Full Application for SNAP and PARTISN

DOE PAGES

Womeldorff, Geoffrey Alan; Payne, Joshua Estes; Bergen, Benjamin Karl

2017-06-09

SNAP is a proxy application which simulates the computational motion of a neutral particle transport code, PARTISN. Here in this work, we have adapted parts of SNAP separately; we have re-implemented the iterative shell of SNAP in the task-model runtime Legion, showing an improvement to the original schedule, and we have created multiple Kokkos implementations of the computational kernel of SNAP, displaying similar performance to the native Fortran. We then translate our Kokkos experiments in SNAP to PARTISN, necessitating engineering development, regression testing, and further thought.

Taking Lessons Learned from a Proxy Application to a Full Application for SNAP and PARTISN

DOE Office of Scientific and Technical Information (OSTI.GOV)

Womeldorff, Geoffrey Alan; Payne, Joshua Estes; Bergen, Benjamin Karl

SNAP is a proxy application which simulates the computational motion of a neutral particle transport code, PARTISN. Here in this work, we have adapted parts of SNAP separately; we have re-implemented the iterative shell of SNAP in the task-model runtime Legion, showing an improvement to the original schedule, and we have created multiple Kokkos implementations of the computational kernel of SNAP, displaying similar performance to the native Fortran. We then translate our Kokkos experiments in SNAP to PARTISN, necessitating engineering development, regression testing, and further thought.

Trends in Pulpwood Prices in the Southeast, 1962-1969

Treesearch

Cecil C. Hutchins

1970-01-01

Average prices paid for pulpwood bolts in the Southeast increased 5 percent in 1969 over the preceding year. Prices paid for roundwood averaged $20.90 per cord for pine and $16.35 for hardwood. Prices paid for chips averaged $8.45 per ton for pine and $6.75 for hardwood. Since 1962, average prices paid for pulpwood have increased by over 25 percent. Pulpmills...

Snapping shrimp sound production patterns on Caribbean coral reefs: relationships with celestial cycles and environmental variables

NASA Astrophysics Data System (ADS)

Lillis, Ashlee; Mooney, T. Aran

2018-06-01

The rich acoustic environment of coral reefs, including the sounds of a variety of fish and invertebrates, is a reflection of the structural complexity and biological diversity of these habitats. Emerging interest in applying passive acoustic monitoring and soundscape analysis to measure coral reef habitat characteristics and track ecological patterns is hindered by a poor understanding of the most common and abundant sound producers on reefs—the snapping shrimp. Here, we sought to address several basic biophysical drivers of reef sound by investigating acoustic activity patterns of snapping shrimp populations on two adjacent coral reefs using a detailed snap detection analysis routine to a high-resolution 2.5-month acoustic dataset from the US Virgin Islands. The reefs exhibited strong diel and lunar periodicity in snap rates and clear spatial differences in snapping levels. Snap rates peaked at dawn and dusk and were higher overall during daytime versus nighttime, a seldom-reported pattern in earlier descriptions of diel snapping shrimp acoustic activity. Small differences between the sites in snap rate rhythms were detected and illustrate how analyses of specific soundscape elements might reveal subtle between-reef variation. Snap rates were highly correlated with environmental variables, including water temperature and light, and were found to be sensitive to changes in oceanographic forcing. This study further establishes snapping shrimp as key players in the coral reef chorus and provides evidence that their acoustic output reflects a combination of environmental conditions, celestial influences, and spatial habitat variation. Effective application of passive acoustic monitoring in coral reef habitats using snap rates or snapping-influenced acoustic metrics will require a mechanistic understanding of the underlying spatial and temporal variation in snapping shrimp sound production across multiple scales.

Alpha-SNAP functions in insulin exocytosis from mature, but not immature secretory granules in pancreatic beta cells.

PubMed

Nakamichi, Y; Nagamatsu, S

1999-06-24

To explore alpha-SNAP function in insulin exocytosis from either immature or mature secretory granules in pancreatic beta cells, we studied the effects of overexpression of adenovirus-mediated wild-type alpha-SNAP and C-terminally deleted alpha-SNAP mutant (1-285) on newly synthesized proinsulin and insulin release by rat islets and MIN6 cells. Rat islets overexpressing alpha-SNAP and mutant alpha-SNAP were pulse-chased. Exocytosis from immature and mature insulin secretory granules was measured as fractional (%) labeled-proinsulin release immediately after the pulse-labeling and percentage labeled-insulin release after a 3-h chase period, respectively. There was no difference in percentage labeled-proinsulin release between the control and alpha-SNAP or mutant alpha-SNAP-overexpressed islets. Although percentage labeled-insulin release after a 3-h chase period was significantly increased in alpha-SNAP-overexpressed islets, it was decreased in mutant alpha-SNAP-overexpressed islets. Thus, the results demonstrated that alpha-SNAP overexpression in rat islets primarily increased exocytosis from mature, but not immature insulin secretory granules. On the other hand, in MIN6 cells, alpha-SNAP overexpression scarcely affected glucose-stimulated insulin release; therefore, we examined the effect of mutant alpha-SNAP overexpression as the dominant-negative inhibitor on the newly synthesized proinsulin/insulin release using the same protocol as in the rat islet experiments. alpha-SNAP mutant (1-285) overexpression in MIN6 cells decreased the percentage labeled insulin release from mature secretory granules, but not percentage labeled proinsulin release from immature secretory granules. Thus, our data demonstrate that alpha-SNAP functions mainly in the mature insulin secretory granules in pancreatic beta cells. Copyright 1999 Academic Press.

NIP-SNAP-1 and -2 mitochondrial proteins are maintained by heat shock protein 60.

PubMed

Yamamoto, Soh; Okamoto, Tomoya; Ogasawara, Noriko; Hashimoto, Shin; Shiraishi, Tsukasa; Sato, Toyotaka; Yamamoto, Keisuke; Tsutsumi, Hiroyuki; Takano, Kenichi; Himi, Testuo; Itoh, Hideaki; Yokota, Shin-Ichi

2017-02-12

NIP-SNAP-1 and -2 are ubiquitous proteins thought to be associated with maintenance of mitochondrial function, neuronal transmission, and autophagy. However, their physiological functions remain largely unknown. To elucidate their functional importance, we screened for proteins that interact with NIP-SNAP-1 and -2, resulting in identification of HSP60 and P62/SQSTM1 as binding proteins. NIP-SNAP-1 and -2 localized in the mitochondrial inner membrane space, whereas HSP60 localized in the matrix. Native gel electrophoresis and filter trap assays revealed that human HSP60 prevented aggregation of newly synthesized NIP-SNAP-2 in an in vitro translation system. Moreover, expression levels of NIP-SNAP-1 and -2 in cells were decreased by knockdown of HSP60, but not HSP10. These findings indicate that HSP60 promotes folding and maintains the stability of NIP-SNAP-1 and -2. Copyright © 2016 Elsevier Inc. All rights reserved.

The research and development program for the SNAP dark energy experiment

NASA Astrophysics Data System (ADS)

Levi, Michael E.

2007-03-01

The SNAP mission includes two surveys to study dark energy. In the deep survey, we detect more than 2000 matched Type Ia supernovae within a 7.5 deg2 field, with redshifts covering the range z=0.1 1.7. This uniform and high-quality set of “standard candles” will provide the most precise mapping of the expansion of the universe through the magnitude-redshift relation (Hubble diagram) ever constructed. The SNAP wide survey maps 1000 deg2/year in nine passbands to 28th magnitude. A weak-lensing study of the wide survey data traces the growth of structure and provides completely independent constraints on dark energy parameters. SNAP utilizes a 2 m class rigid light-weight telescope with a three-mirror anastigmatic design for a large, diffraction-limited field of view. The telescope feeds an instrumented ˜0.7 deg2 focal plane with ˜600 million pixels sensitive to wavelengths from 400 to 1700 nm. Full-depletion, high-purity silicon CCDs detect visible wavelengths, and 1700 nm cutoff HgCdTe detector arrays detect the near-IR. Passive cooling of the focal plane, fixed solar panels, fixed filters, and fixed antenna for telemetry simplify the mission. Room temperature operation of the telescope facilitates preflight testing. The satellite is placed in orbit about the second Earth Sun Lagrange point (L2).

SnapShot: The Bacterial Cytoskeleton.

PubMed

Fink, Gero; Szewczak-Harris, Andrzej; Löwe, Jan

2016-07-14

Most bacteria and archaea contain filamentous proteins and filament systems that are collectively known as the bacterial cytoskeleton, though not all of them are cytoskeletal, affect cell shape, or maintain intracellular organization. To view this SnapShot, open or download the PDF. Copyright © 2016. Published by Elsevier Inc.

Developmentally regulated switch in alternatively spliced SNAP-25 isoforms alters facilitation of synaptic transmission.

PubMed

Bark, Christina; Bellinger, Frederick P; Kaushal, Ashutosh; Mathews, James R; Partridge, L Donald; Wilson, Michael C

2004-10-06

Although the basic molecular components that promote regulated neurotransmitter release are well established, the contribution of these proteins as regulators of the plasticity of neurotransmission and refinement of synaptic connectivity during development is elaborated less fully. For example, during the period of synaptic growth and maturation in brain, the expression of synaptosomal protein 25 kDa (SNAP-25), a neuronal t-SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) essential for action potential-dependent neuroexocytosis, is altered through alternative splicing of pre-mRNA transcripts. We addressed the role of the two splice-variant isoforms of SNAP-25 with a targeted mouse mutation that impairs the shift from SNAP-25a to SNAP-25b. Most of these mutant mice die between 3 and 5 weeks of age, which coincides with the time when SNAP-25b expression normally reaches mature levels in brain and synapse formation is essentially completed. The altered expression of these SNAP-25 isoforms influences short-term synaptic function by affecting facilitation but not the initial probability of release. This suggests that mechanisms controlling alternative splicing between SNAP-25 isoforms contribute to a molecular switch important for survival that helps to guide the transition from immature to mature synaptic connections, as well as synapse regrowth and remodeling after neural injury.

α-SNAP regulates dynamic, on-site assembly and calcium selectivity of Orai1 channels.

PubMed

Li, Peiyao; Miao, Yong; Dani, Adish; Vig, Monika

2016-08-15

Orai1 forms a highly calcium-selective pore of the calcium release activated channel, and α-SNAP is necessary for its function. Here we show that α-SNAP regulates on-site assembly of Orai1 dimers into calcium-selective multimers. We find that Orai1 is a dimer in resting primary mouse embryonic fibroblasts but displays variable stoichiometry in the plasma membrane of store-depleted cells. Remarkably, α-SNAP depletion induces formation of higher-order Orai1 oligomers, which permeate significant levels of sodium via Orai1 channels. Sodium permeation in α-SNAP-deficient cells cannot be corrected by tethering multiple Stim1 domains to Orai1 C-terminal tail, demonstrating that α-SNAP regulates functional assembly and calcium selectivity of Orai1 multimers independently of Stim1 levels. Fluorescence nanoscopy reveals sustained coassociation of α-SNAP with Stim1 and Orai1, and α-SNAP-depleted cells show faster and less constrained mobility of Orai1 within ER-PM junctions, suggesting Orai1 and Stim1 coentrapment without stable contacts. Furthermore, α-SNAP depletion significantly reduces fluorescence resonance energy transfer between Stim1 and Orai1 N-terminus but not C-terminus. Taken together, these data reveal a unique role of α-SNAP in the on-site functional assembly of Orai1 subunits and suggest that this process may, in part, involve enabling crucial low-affinity interactions between Orai1 N-terminus and Stim1. © 2016 Li, Miao, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

7 CFR 1962.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-01-01

... of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... REGULATIONS (CONTINUED) PERSONAL PROPERTY Servicing and Liquidation of Chattel Security § 1962.1 Purpose. This... 103-354) chattel security, Economic Opportunity (EO) loan property, and note only loans. Security...

Vortex formation with a snapping shrimp claw.

PubMed

Hess, David; Brücker, Christoph; Hegner, Franziska; Balmert, Alexander; Bleckmann, Horst

2013-01-01

Snapping shrimp use one oversized claw to generate a cavitating high speed water jet for hunting, defence and communication. This work is an experimental investigation about the jet generation. Snapping shrimp (Alpheus-bellulus) were investigated by using an enlarged transparent model reproducing the closure of the snapper claw. Flow inside the model was studied using both High-Speed Particle Image Velocimetry (HS-PIV) and flow visualization. During claw closure a channel-like cavity was formed between the plunger and the socket featuring a nozzle-type contour at the orifice. Closing the mechanism led to the formation of a leading vortex ring with a dimensionless formation number of approximate ΔT*≈4. This indicates that the claw might work at maximum efficiency, i.e. maximum vortex strength was achieved by a minimum of fluid volume ejected. The subsequent vortex cavitation with the formation of an axial reentrant jet is a reasonable explanation for the large penetration depth of the water jet. That snapping shrimp can reach with their claw-induced flow. Within such a cavitation process, an axial reentrant jet is generated in the hollow cylindrical core of the cavitated vortex that pushes the front further downstream and whose length can exceed the initial jet penetration depth by several times.

Hunting for ghosts in elastic snap-through

NASA Astrophysics Data System (ADS)

Gomez, Michael; Moulton, Derek E.; Vella, Dominic

Elastic `snap-through' is a striking instability often seen when an elastic system loses bistability, e.g. due to a change in geometry or external loading. The switch from one state to another is generally rapid and hence is used to generate fast motions in biology and engineering. While the onset of instability has been well studied, the dynamics of the transition itself remain much less well understood. For example, the dynamics exhibited by children's jumping popper toys, or the leaves of the Venus flytrap plant, are much slower than would be expected based on a naive estimate of the elastic timescales. To explain this discrepancy, the natural conclusion has been drawn that some other effect, such as viscoelasticity, must play a role. We demonstrate here that purely elastic systems may show similar `slow' dynamics during snap-through. This behaviour is due to a remnant (or `ghost') of the snap-through bifurcation underlying the instability, analogously to bottleneck phenomena in 1-D dynamical systems. This slowness is a generic consequence of being close to bifurcation -- it does not require dissipation. We obtain scaling laws for the length of the delay and compare these to numerical simulations and experiments on real samples.

Applications Where Snap is BPM for Radioactive Waste Assay

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, T.J.

2008-07-01

Historically, the Atomic Weapons Establishment (AWE) at Aldermaston in the United Kingdom (UK), has used a variety of assay techniques to measure the radioactive content of a diverse range of waste packages from decommissioning, operational and legacy sources. The regulator, the Environment Agency in the UK, places conditions and limits on AWE through an authorisation within the Radioactive Substances Act (RSA93). The conditions and limits require Best Practical Means (BPM) measurements to be used to demonstrate compliance with the authorisation. Hence, the assay technique employed needs to achieve a balance between risk of exposure, environmental considerations, technological considerations, health andmore » safety considerations and cost effectiveness, without being grossly disproportionate in terms of money, time or trouble. Recently published work has concluded that the Spectral Non-destructive Assay Platform (SNAP) assay system is BPM for Depleted Uranium (DU) waste assay at AWE (1) and low level plutonium in soft drummed waste, HEPA filters and soils (2-4). The purpose of this paper is to highlight other applications where SNAP represents BPM for radioactive waste assay. This has been done by intercomparison studies of SNAP with other assay techniques, such as Segmented Gamma Scanner (SGS) and Passive Neutron Coincidence Counter (PNCC). It has been concluded that, for a large range of waste packages encountered at AWE, SNAP is BPM. (author)« less

7 CFR 1962.2 - Policy.

Code of Federal Regulations, 2010 CFR

2010-01-01

... of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... REGULATIONS (CONTINUED) PERSONAL PROPERTY Servicing and Liquidation of Chattel Security § 1962.2 Policy. Chattel security, EO property and note only loans will be serviced to accomplish the loan objectives and...

7 CFR 1962.29 - Payment of fees and insurance premiums.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 14 2010-01-01 2009-01-01 true Payment of fees and insurance premiums. 1962.29... Security § 1962.29 Payment of fees and insurance premiums. (a) Fees. (1) Security instruments. Borrowers... the service cannot be obtained without cost. (b) Insurance premiums. County Supervisors are authorized...

7 CFR 1962.29 - Payment of fees and insurance premiums.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 14 2011-01-01 2011-01-01 false Payment of fees and insurance premiums. 1962.29... Security § 1962.29 Payment of fees and insurance premiums. (a) Fees. (1) Security instruments. Borrowers... the service cannot be obtained without cost. (b) Insurance premiums. County Supervisors are authorized...

Episodic snapping of the medial head of the triceps due to weightlifting.

PubMed

Spinner, R J; Wenger, D E; Barry, C J; Goldner, R D

1999-01-01

We describe two patients who had episodic elbow snapping and ulnar nerve dysesthesias only after weightlifting. These symptoms would disappear soon afterward. The episodic nature of their complaints and findings led to misdiagnosis. We documented by repeated clinical examinations and magnetic resonance imaging that the presence of these symptoms correlated directly with the finding of intermittent, activity-related snapping of the medial triceps. In both patients, the symptoms disappeared when the medial portion of the triceps migrated medially but did not dislocate over the medial epicondyle with elbow flexion. Thus, a minor change in the configuration of the medial portion of the triceps (fluid accumulation) in the same individual at different times can cause intermittent dislocation of the medial triceps. Previous papers dealing with patients with snapping of the medial triceps describe symptoms exacerbated by athletic activities, but the constant finding of snapping on sequential examinations.

α-SNAP regulates dynamic, on-site assembly and calcium selectivity of Orai1 channels

PubMed Central

Li, Peiyao; Miao, Yong; Dani, Adish; Vig, Monika

2016-01-01

Orai1 forms a highly calcium-selective pore of the calcium release activated channel, and α-SNAP is necessary for its function. Here we show that α-SNAP regulates on-site assembly of Orai1 dimers into calcium-selective multimers. We find that Orai1 is a dimer in resting primary mouse embryonic fibroblasts but displays variable stoichiometry in the plasma membrane of store-depleted cells. Remarkably, α-SNAP depletion induces formation of higher-order Orai1 oligomers, which permeate significant levels of sodium via Orai1 channels. Sodium permeation in α-SNAP–deficient cells cannot be corrected by tethering multiple Stim1 domains to Orai1 C-terminal tail, demonstrating that α-SNAP regulates functional assembly and calcium selectivity of Orai1 multimers independently of Stim1 levels. Fluorescence nanoscopy reveals sustained coassociation of α-SNAP with Stim1 and Orai1, and α-SNAP–depleted cells show faster and less constrained mobility of Orai1 within ER-PM junctions, suggesting Orai1 and Stim1 coentrapment without stable contacts. Furthermore, α-SNAP depletion significantly reduces fluorescence resonance energy transfer between Stim1 and Orai1 N-terminus but not C-terminus. Taken together, these data reveal a unique role of α-SNAP in the on-site functional assembly of Orai1 subunits and suggest that this process may, in part, involve enabling crucial low-affinity interactions between Orai1 N-terminus and Stim1. PMID:27335124

78 FR 52899 - Supplemental Nutrition Assistance Program (SNAP) Enhancing Retail Food Store Eligibility...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-27

... DEPARTMENT OF AGRICULTURE Food and Nutrition Service Supplemental Nutrition Assistance Program (SNAP) Enhancing Retail Food Store Eligibility--Listening Sessions AGENCY: Food and Nutrition Service... for Information (RFI) published by FNS regarding Supplemental Nutrition Assistance Program (SNAP...

Shock and vibration tests of a SNAP-8 NaK pump

NASA Technical Reports Server (NTRS)

Stromquist, A. J.; Nelson, R. B.; Hibben, L.

1971-01-01

The pump used for reactor cooling in the SNAP 8 space power system was subjected to the expected vehicle launch vibration, and shock loading in accordance with the SNAP 8 environmental specification. Subsequent disassembly revealed damage to the thrust bearing pins, which should be redesigned and strengthened. The unit was operational, however, when run in a test loop after reassembly.

Production Program - Operational - SNAP 10A Units

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1961-08-07

This planning report is provided to describe the lead time, approximate costs, and major decisions and approvals required to enter a production program for the 500 watt SNAP 10A nuclear space power system.

Scapulothoracic bursitis and snapping scapula syndrome: a critical review of current evidence.

PubMed

Warth, Ryan J; Spiegl, Ulrich J; Millett, Peter J

2015-01-01

Symptomatic scapulothoracic disorders, such as painful scapular crepitus and/or bursitis, are uncommon; however, they can produce significant pain and disability in many patients. To review the current knowledge pertaining to snapping scapula syndrome and to identify areas of further research that may be helpful to improve clinical outcomes and patient satisfaction. Systematic review. We performed a preliminary search of the PubMed and Embase databases using the search terms "snapping scapula," "scapulothoracic bursitis," "partial scapulectomy," and "superomedial angle resection" in September 2013. All nonreview articles related to the topic of snapping scapula syndrome were included. The search identified a total of 167 unique articles, 81 of which were relevant to the topic of snapping scapula syndrome. There were 36 case series of fewer than 10 patients, 16 technique papers, 11 imaging studies, 9 anatomic studies, and 9 level IV outcomes studies. The level of evidence obtained from this literature search was inadequate to perform a formal systematic review or meta-analysis. Therefore, a critical review of current evidence is presented. Snapping scapula syndrome, a likely underdiagnosed condition, can produce significant shoulder dysfunction in many patients. Because the precise origin is typically unknown, specific treatments that are effective for some patients may not be effective for others. Nevertheless, bursectomy with or without partial scapulectomy is currently the most effective primary method of treatment in patients who fail nonoperative therapy. However, many patients experience continued shoulder disability even after surgical intervention. Future studies should focus on identifying the modifiable factors associated with poor outcomes after operative and nonoperative management for snapping scapula syndrome in an effort to improve clinical outcomes and patient satisfaction. © 2014 The Author(s).

Snap-through instability analysis of dielectric elastomers with consideration of chain entanglements

NASA Astrophysics Data System (ADS)

Zhu, Jiakun; Luo, Jun; Xiao, Zhongmin

2018-06-01

It is widely recognized that the extension limit of polymer chains has a significant effect on the snap-through instability of dielectric elastomers (DEs). The snap-through instability performance of DEs has been extensively studied by two limited-stretch models, i.e., the eight-chain model and Gent model. However, the real polymer networks usually have many entanglements due to the impenetrability of the network chains as well as a finite extensibility resulting from the full stretching of the polymer chains. The effects of entanglements on the snap-through instability of DEs cannot be captured by the previous two limited-stretch models. In this paper, the nonaffine model proposed by Davidson and Goulbourne is adopted to characterize the influence of entanglements and extension limit of the polymer chains. It is demonstrated that the nonaffine model is almost identical to the eight-chain model and is close to the Gent model if we ignore the effects of chain entanglements and adopt the affine assumption. The suitability of the nonaffine model to characterize the mechanical behavior of elastomers is validated by fitting the experimental results reported in the open literature. After that, the snap-through stability performance of an ideal DE membrane under equal-biaxial prestretches is studied with the nonaffine model. It is revealed that besides the prestretch and chain extension limit, the chain entanglements can markedly influence the snap-through instability and the path to failure of DEs. These results provide a more comprehensive understanding on the snap-through instability of a DE and may be helpful to guide the design of DE devices.

Evaluation of diamide insecticides co-applied with other agrochemicals at various times to manage Ostrinia nubilalis in processing snap bean.

PubMed

Huseth, Anders S; Groves, Russell L; Chapman, Scott A; Nault, Brian A

2015-12-01

Multiple applications of pyrethroid insecticides are used to manage European corn borer, Ostrinia nubilalis Hübner, in snap bean, but new diamide insecticides may reduce application frequency. In a 2 year small-plot study, O. nubilalis control was evaluated by applying cyantraniliprole (diamide) and bifenthrin (pyrethroid) insecticides at one of three phenological stages (bud, bloom and pod formation) of snap bean development. Co-application of these insecticides with either herbicides or fungicides was also examined as a way to reduce the total number of sprays during a season. Cyantraniliprole applications timed either during bloom or during pod formation controlled O. nubilalis better than similar timings of bifenthrin. Co-applications of insecticides with fungicides controlled O. nubilalis as well as insecticide applications alone. Insecticides applied either alone or with herbicides during bud stage did not control this pest. Diamides are an alternative to pyrethroids for the management of O. nubilalis in snap bean. Adoption of diamides by snap bean growers could improve the efficiency of production by reducing the number of sprays required each season. © 2015 Society of Chemical Industry.

Validation of a Computerized Adaptive Version of the Schedule for Nonadaptive and Adaptive Personality (SNAP)

ERIC Educational Resources Information Center

Simms, Leonard J.; Clark, Lee Anna

2005-01-01

This is a validation study of a computerized adaptive (CAT) version of the Schedule for Nonadaptive and Adaptive Personality (SNAP) conducted with 413 undergraduates who completed the SNAP twice, 1 week apart. Participants were assigned randomly to 1 of 4 retest groups: (a) paper-and-pencil (P&P) SNAP, (b) CAT, (c) P&P/CAT, and (d) CAT/P&P. With…

Experimental Criticality Benchmarks for SNAP 10A/2 Reactor Cores

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krass, A.W.

2005-12-19

This report describes computational benchmark models for nuclear criticality derived from descriptions of the Systems for Nuclear Auxiliary Power (SNAP) Critical Assembly (SCA)-4B experimental criticality program conducted by Atomics International during the early 1960's. The selected experimental configurations consist of fueled SNAP 10A/2-type reactor cores subject to varied conditions of water immersion and reflection under experimental control to measure neutron multiplication. SNAP 10A/2-type reactor cores are compact volumes fueled and moderated with the hydride of highly enriched uranium-zirconium alloy. Specifications for the materials and geometry needed to describe a given experimental configuration for a model using MCNP5 are provided. Themore » material and geometry specifications are adequate to permit user development of input for alternative nuclear safety codes, such as KENO. A total of 73 distinct experimental configurations are described.« less

SNAP-25 requirement for dendritic growth of hippocampal neurons.

PubMed

Grosse, G; Grosse, J; Tapp, R; Kuchinke, J; Gorsleben, M; Fetter, I; Höhne-Zell, B; Gratzl, M; Bergmann, M

1999-06-01

Structure and dimension of the dendritic arbor are important determinants of information processing by the nerve cell, but mechanisms and molecules involved in dendritic growth are essentially unknown. We investigated early mechanisms of dendritic growth using mouse fetal hippocampal neurons in primary culture, which form processes during the first week in vitro. We detected a key component of regulated exocytosis, SNAP-25 (synaptosomal associated protein of 25 kDa), in axons and axonal terminals as well as in dendrites identified by the occurrence of the dendritic markers transferrin receptor and MAP2. Selective inactivation of SNAP-25 by botulinum neurotoxin A (BoNTA) resulted in inhibition of axonal growth and of vesicle recycling in axonal terminals. In addition, dendritic growth of hippocampal pyramidal and granule neurons was significantly inhibited by BoNTA. In contrast, cleavage of synaptobrevin by tetanus toxin had an effect on neither axonal nor dendritic growth. Our observations indicate that SNAP-25, but not synaptobrevin, is involved in constitutive axonal growth and dendrite formation by hippocampal neurons.

Cell-Specific Loss of SNAP25 from Cortical Projection Neurons Allows Normal Development but Causes Subsequent Neurodegeneration.

PubMed

Hoerder-Suabedissen, Anna; Korrell, Kim V; Hayashi, Shuichi; Jeans, Alexander; Ramirez, Denise M O; Grant, Eleanor; Christian, Helen C; Kavalali, Ege T; Wilson, Michael C; Molnár, Zoltán

2018-05-30

Synaptosomal associated protein 25 kDa (SNAP25) is an essential component of the SNARE complex regulating synaptic vesicle fusion. SNAP25 deficiency has been implicated in a variety of cognitive disorders. We ablated SNAP25 from selected neuronal populations by generating a transgenic mouse (B6-Snap25tm3mcw (Snap25-flox)) with LoxP sites flanking exon5a/5b. In the presence of Cre-recombinase, Snap25-flox is recombined to a truncated transcript. Evoked synaptic vesicle release is severely reduced in Snap25 conditional knockout (cKO) neurons as shown by live cell imaging of synaptic vesicle fusion and whole cell patch clamp recordings in cultured hippocampal neurons. We studied Snap25 cKO in subsets of cortical projection neurons in vivo (L5-Rbp4-Cre; L6-Ntsr1-Cre; L6b-Drd1a-Cre). cKO neurons develop normal axonal projections, but axons are not maintained appropriately, showing signs of swelling, fragmentation and eventually complete absence. Onset and progression of degeneration are dependent on the neuron type, with L5 cells showing the earliest and most severe axonal loss. Ultrastructural examination revealed that cKO neurites contain autophagosome/lysosome-like structures. Markers of inflammation such as Iba1 and lipofuscin are increased only in adult cKO cortex. Snap25 cKO can provide a model to study genetic interactions with environmental influences in several disorders.

A Follow-Up Study of the Participants of the Nine National Science Foundation Academic Year Institutes for Junior High School Teachers of Mathematics Held at San Jose State College, 1962 to 1970.

ERIC Educational Resources Information Center

Merkel, Joseph G.

This report is based on 144 questionnaires sent to past participants of the nine National Science Foundation Academic Year Institutes (AYI) for Junior High School Teachers of Mathematics held at San Jose State College, 1962-1970. The questionnaires, sent to each participant in May of the year following completion of their institute, lists 25…

The SNAP System for Inservice Training of Regular Educators. Final Project Report.

ERIC Educational Resources Information Center

Malouf, David B.; Pilato, Virginia H.

This report discusses a project to develop, test, and disseminate the SNAP (Smart Needs Assessment Program) system for needs assessment and inservice training of regular educators to work with students with disabilities. The SNAP system is an expert system that defines the training needs of individual teachers and links these needs with training…

Louisiana forest industry statistics, 1962

Treesearch

Joe F. Christopher; Erin R. Gunter

1963-01-01

This report summarizes information on the 1962 production of industrial roundwood (except pulpwood) in Louisiana. Because parish output is included--as well as State totals--this report should be locally useful to foresters, economists, and others concerned with the formation of forestry programs, the evaluation of timber production trends, the appraisal of plant...

A comparison of bottles and snap traps for short-term small mammal sampling

Treesearch

James F. Taulman; Ronald E. Thill; T. Bently Wigley; M. Anthony Melchiors

1992-01-01

Bottles were tested as traps for small mammals. Used in conjunction with three types of snap traps over 30,240 trap nights, bottles captured eight (2%) of the total 421 mammals taken. Bottles were inefficient in capturing small mammals compared to snap traps.

The unhealthy food environment does not modify the association between obesity and participation in the Supplemental Nutrition Assistance Program (SNAP) in Los Angeles County.

PubMed

Chaparro, M Pia; Harrison, Gail G; Wang, May C; Seto, Edmund Y W; Pebley, Anne R

2017-01-14

Participation in the Supplemental Nutrition Assistance Program (SNAP) has been linked to an increased risk of obesity, but not much is known about the mechanisms behind this association. The objective of this study was to determine if the neighborhood density of unhealthy food outlets modifies the association between obesity and participation in SNAP. Data comes from the first wave of the Los Angeles Family and Neighborhood Survey; included are a subsample of adults (18+ years) who were SNAP participants or eligible non-participants (N = 1,176). We carried out multilevel analyses with obesity (BMI ≥ 30 Kg/m 2 ), SNAP participation, and the neighborhood density of unhealthy food outlets as dependent, independent and modifying variables, respectively, controlling for age, gender, race/ethnicity, marital status, working status, mental health, and neighborhood poverty. SNAP participants had double the odds of obesity compared to eligible non-participants (OR = 2.02; 95%CI = 1.44-2.83). However, the neighborhood density of unhealthy food outlets did not modify this association. SNAP participation was associated with higher odds of obesity in our primarily Hispanic sample in Los Angeles County, with no effect modification found for the unhealthy portion of the food environment. More research is needed with additional food environment measures to confirm our null findings. Additional research is needed to elucidate the mechanisms linking SNAP participation and obesity as they remain unclear.

Myosin phosphatase and RhoA-activated kinase modulate neurotransmitter release by regulating SNAP-25 of SNARE complex

PubMed Central

Sipos, Adrienn; Darula, Zsuzsanna; Bécsi, Bálint; Nagy, Dénes; Iván, Judit; Erdődi, Ferenc

2017-01-01

Reversible phosphorylation of neuronal proteins plays an important role in the regulation of neurotransmitter release. Myosin phosphatase holoenzyme (MP) consists of a protein phosphatase-1 (PP1) catalytic subunit (PP1c) and a regulatory subunit, termed myosin phosphatase targeting subunit (MYPT1). The primary function of MP is to regulate the phosphorylation level of contractile proteins; however, recent studies have shown that MP is localized to neurons, and is also involved in the mediation of neuronal processes. Our goal was to investigate the effect of RhoA-activated kinase (ROK) and MP on the phosphorylation of one potential neuronal substrate, the synaptosomal-associated protein of 25 kDa (SNAP-25). SNAP-25 is a member of the SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptor) complex, along with synaptobrevin and syntaxin, and the primary role of SNAP25 is to mediate vesicle fusion. We showed that MYPT1 interacts with SNAP-25, as revealed by immunoprecipitation and surface plasmon resonance based binding studies. Mass spectrometry analysis and in vitro phosphorylation/dephosphorylation assays demonstrated that ROK phosphorylates, while MP dephosphorylates, SNAP-25 at Thr138. Silencing MYPT1 in B50 neuroblastoma cells increased phosphorylation of SNAP-25 at Thr138. Inhibition of PP1 with tautomycetin increased, whereas inhibition of ROK by H1152, decreased the phosphorylation of SNAP-25 at Thr138 in B50 cells, in cortical synaptosomes, and in brain slices. In response to the transduction of the MP inhibitor, kinase-enhanced PP1 inhibitor (KEPI), into synaptosomes, an increase in phosphorylation of SNAP-25 and a decrease in the extent of neurotransmitter release were detected. The interaction between SNAP-25 and syntaxin increased with decreasing phosphorylation of SNAP-25 at Thr138, upon inhibition of ROK. Our data suggest that ROK/MP play a crucial role in vesicle trafficking, fusion, and neurotransmitter release by oppositely

Mammalian DNA enriched for replication origins is enriched for snap-back sequences.

PubMed

Zannis-Hadjopoulos, M; Kaufmann, G; Martin, R G

1984-11-15

Using the instability of replication loops as a method for the isolation of double-stranded nascent DNA, extruded DNA enriched for replication origins was obtained and denatured. Snap-back DNA, single-stranded DNA with inverted repeats (palindromic sequences), reassociates rapidly into stem-loop structures with zero-order kinetics when conditions are changed from denaturing to renaturing, and can be assayed by chromatography on hydroxyapatite. Origin-enriched nascent DNA strands from mouse, rat and monkey cells growing either synchronously or asynchronously were purified and assayed for the presence of snap-back sequences. The results show that origin-enriched DNA is also enriched for snap-back sequences, implying that some origins for mammalian DNA replication contain or lie near palindromic sequences.

SNAP Participants' Eating Patterns over the Benefit Month: A Time Use Perspective.

PubMed

Hamrick, Karen S; Andrews, Margaret

2016-01-01

Individuals receiving monthly benefits through the U.S. Supplemental Nutrition Assistance Program (SNAP) often fall short of food at the end of the month and some report feelings of hunger. To investigate this situation, we used time diaries from the 2006-08 American Time Use Survey and Eating & Health Module to identify the timing of days where respondents reported no eating occurrences. Analysis includes descriptive statistics, a logit model, and a simulated benefit month. We found that SNAP participants were increasingly more likely than nonparticipants to report a day with no eating occurrences over the benefit issuance cycle. This supports the view that there is a monthly cycle in food consumption associated with the SNAP monthly benefit issuance policy.

The development of Version 2 of the AN-SNAP casemix classification system.

PubMed

Green, Janette; Gordon, Robert

2007-04-01

This paper presents the results of a recent review of the Australian National Sub-acute and Non-acute Patient (AN-SNAP) classification system. The AN-SNAP system was developed by the Centre for Health Service Development, University of Wollongong in 1997. The review was conducted between August 2005 and September 2006. Four clinical sub-committees comprising more than 50 clinicians from sub-acute services across New South Wales as well as representatives from Queensland and the Australian Capital Territory were established to develop a set of proposals to be considered for incorporation into Version 2 of the classification. It is proposed that the final AN-SNAP Version 2 classification will be available for implementation from 1 July 2007.

Syntheses of precursors and reference compounds of the melanin-concentrating hormone receptor 1 (MCHR1) tracers [¹¹C]SNAP-7941 and [¹⁸F]FE@SNAP for positron emission tomography.

PubMed

Schirmer, Eva; Shanab, Karem; Datterl, Barbara; Neudorfer, Catharina; Mitterhauser, Markus; Wadsak, Wolfgang; Philippe, Cécile; Spreitzer, Helmut

2013-09-30

The MCH receptor has been revealed as a target of great interest in positron emission tomography imaging. The receptor's eponymous substrate melanin-concentrating hormone (MCH) is a cyclic peptide hormone, which is located predominantly in the hypothalamus with a major influence on energy and weight regulation as well as water balance and memory. Therefore, it is thought to play an important role in the pathophysiology of adiposity, which is nowadays a big issue worldwide. Based on the selective and high-affinity MCH receptor 1 antagonist SNAP-7941, a series of novel SNAP derivatives has been developed to provide different precursors and reference compounds for the radiosyntheses of the novel PET radiotracers [(11)C]SNAP-7941 and [(18)F]FE@SNAP. Positron emission tomography promotes a better understanding of physiologic parameters on a molecular level, thus giving a deeper insight into MCHR1 related processes as adiposity.

Mississippi forest industry statistics, 1962

Treesearch

Joe F. Christopher

1963-01-01

This report summarizes information on the 1962 production of industrial roundwood (except pu1pwood)in Mississippi. Because county output is included--as well as State totals--this report should be locally useful to foresters, economists, and others concerned with the formation of forestry programs, the evaluation of timber production trends, the appraisal of plant...

Strategies to improve the dietary quality of Supplemental Nutrition Assistance Program (SNAP) beneficiaries: an assessment of stakeholder opinions.

PubMed

Blumenthal, Susan J; Hoffnagle, Elena E; Leung, Cindy W; Lofink, Hayley; Jensen, Helen H; Foerster, Susan B; Cheung, Lilian Wy; Nestle, Marion; Willett, Walter C

2014-12-01

To examine the opinions of stakeholders on strategies to improve dietary quality of Supplemental Nutrition Assistance Program (SNAP) participants. Participants answered a thirty-eight-item web-based survey assessing opinions and perceptions of SNAP and programme policy changes. Survey of 522 individuals with stakeholder interest in SNAP, conducted in October through December 2011. The top three barriers to improving dietary quality identified were: (i) unhealthy foods marketed in low-income communities; (ii) the high cost of healthy foods; and (iii) lifestyle challenges faced by low-income individuals. Many respondents (70 %) also disagreed that current SNAP benefit levels were adequate to maintain a healthy diet. Stakeholders believed that vouchers, coupons or monetary incentives for purchasing healthful foods might have the greatest potential for improving the diets of SNAP participants. Many respondents (78 %) agreed that sodas should not be eligible for purchases with SNAP benefits. More than half (55 %) believed retailers could easily implement such restrictions. A majority of respondents (58 %) agreed that stores should stock a minimum quantity of healthful foods in order to be certified as a SNAP retailer, and most respondents (83 %) believed that the US Department of Agriculture should collect data on the foods purchased with SNAP benefits. Results suggest that there is broad stakeholder support for policies that align SNAP purchase eligibility with national public health goals of reducing food insecurity, improving nutrition and preventing obesity.

Developmental and diurnal expression of the synaptosomal-associated protein 25 (Snap25) in the rat pineal gland.

PubMed

Karlsen, Anna S; Rath, Martin F; Rohde, Kristian; Toft, Trine; Møller, Morten

2013-06-01

Snap25 (synaptosomal-associated protein) is a 25 kDa protein, belonging to the SNARE-family (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) of proteins, essential for synaptic and secretory vesicle exocytosis. Snap25 has by immunohistochemistry been demonstrated in the rat pineal gland but the biological importance of this is unknown. In this study, we demonstrate a high expression of mRNA encoding Snap25 in all parts of the rat pineal complex, the superficial-, and deep-pineal gland, as well as in the pineal stalk. Snap25 showed a low pineal expression during embryonic stages with a strong increase in expression levels just after birth. The expression showed no day/night variations. Neither removal of the sympathetic input to the pineal gland by superior cervical ganglionectomy nor bilateral decentralization of the superior cervical ganglia significantly affected the expression of Snap25 in the gland. The pineal expression levels of Snap25 were not changed following intraperitoneal injection of isoproterenol. The strong expression of Snap25 in the pineal gland suggests the presence of secretory granules and microvesicles in the rat pinealocyte supporting the concept of a vesicular release. At the transcriptional level, this Snap25-based release mechanism does not exhibit any diurnal rhythmicity and is regulated independently of the sympathetic nervous input to the gland.

Concentration of tobacco advertisements at SNAP and WIC stores, Philadelphia, Pennsylvania, 2012.

PubMed

Hillier, Amy; Chilton, Mariana; Zhao, Qian-Wei; Szymkowiak, Dorota; Coffman, Ryan; Mallya, Giridhar

2015-02-05

Tobacco advertising is widespread in urban areas with racial/ethnic minority and low-income households that participate in nutrition assistance programs. Tobacco sales and advertising are linked to smoking behavior, which may complicate matters for low-income families struggling with disparate health risks relating to nutrition and chronic disease. We investigated the relationship between the amount and type of tobacco advertisements on tobacco outlets and the outlet type and location. By using field visits and online images, we inspected all licensed tobacco retail outlets in Philadelphia (N = 4,639). Point pattern analyses were used to identify significant clustering of tobacco outlets and outlets with exterior tobacco advertisements. Logistic regression was used to analyze the relationship between the outlet's acceptance of Supplemental Nutrition Assistance Program (SNAP) and Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) and the presence of tobacco advertisements. Tobacco outlets with exterior tobacco advertisements were significantly clustered in several high-poverty areas. Controlling for racial/ethnic and income composition and land use, SNAP and WIC vendors were significantly more likely to have exterior (SNAP odds ratio [OR], 2.11; WIC OR, 1.59) and interior (SNAP OR, 3.43; WIC OR, 1.69) tobacco advertisements than other types of tobacco outlets. Tobacco advertising is widespread at retail outlets, particularly in low-income and racial/ethnic minority neighborhoods. Policy makers may be able to mitigate the effects of this disparate exposure through tobacco retail licensing, local sign control rules, and SNAP and WIC authorization.

α-SNAP Interferes with the Zippering of the SNARE Protein Membrane Fusion Machinery

PubMed Central

Park, Yongsoo; Vennekate, Wensi; Yavuz, Halenur; Preobraschenski, Julia; Hernandez, Javier M.; Riedel, Dietmar; Walla, Peter Jomo; Jahn, Reinhard

2014-01-01

Neuronal exocytosis is mediated by soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins. Before fusion, SNARE proteins form complexes bridging the membrane followed by assembly toward the C-terminal membrane anchors, thus initiating membrane fusion. After fusion, the SNARE complex is disassembled by the AAA-ATPase N-ethylmaleimide-sensitive factor that requires the cofactor α-SNAP to first bind to the assembled SNARE complex. Using chromaffin granules and liposomes we now show that α-SNAP on its own interferes with the zippering of membrane-anchored SNARE complexes midway through the zippering reaction, arresting SNAREs in a partially assembled trans-complex and preventing fusion. Intriguingly, the interference does not result in an inhibitory effect on synaptic vesicles, suggesting that membrane properties also influence the final outcome of α-SNAP interference with SNARE zippering. We suggest that binding of α-SNAP to the SNARE complex affects the ability of the SNARE complex to harness energy or transmit force to the membrane. PMID:24778182

7 CFR 1962.8 - Liens on real estate for additional security.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 14 2012-01-01 2012-01-01 false Liens on real estate for additional security. 1962.8... Security § 1962.8 Liens on real estate for additional security. The County Supervisor may take the best lien obtainable on any real estate owned by the borrower, including any real estate which already...

7 CFR 1962.8 - Liens on real estate for additional security.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 14 2014-01-01 2014-01-01 false Liens on real estate for additional security. 1962.8... Security § 1962.8 Liens on real estate for additional security. The County Supervisor may take the best lien obtainable on any real estate owned by the borrower, including any real estate which already...

7 CFR 1962.8 - Liens on real estate for additional security.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 14 2011-01-01 2011-01-01 false Liens on real estate for additional security. 1962.8... Security § 1962.8 Liens on real estate for additional security. The County Supervisor may take the best lien obtainable on any real estate owned by the borrower, including any real estate which already...

7 CFR 1962.8 - Liens on real estate for additional security.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 14 2010-01-01 2009-01-01 true Liens on real estate for additional security. 1962.8... Security § 1962.8 Liens on real estate for additional security. The County Supervisor may take the best lien obtainable on any real estate owned by the borrower, including any real estate which already...

7 CFR 1962.8 - Liens on real estate for additional security.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 14 2013-01-01 2013-01-01 false Liens on real estate for additional security. 1962.8... Security § 1962.8 Liens on real estate for additional security. The County Supervisor may take the best lien obtainable on any real estate owned by the borrower, including any real estate which already...

Role of "Sural Sparing" Pattern (Absent/Abnormal Median and Ulnar with Present Sural SNAP) Compared to Absent/Abnormal Median or Ulnar with Normal Sural SNAP in Acute Inflammatory Demyelinating Polyneuropathy.

PubMed

Surpur, Spurthi Sunil; Govindarajan, Raghav

2017-01-01

Sural sparing defined as absent/abnormal median sensory nerve action potential (SNAP) amplitude or absent/abnormal ulnar SNAP amplitude with a normal sural SNAP amplitude is thought to be a marker for inflammatory demyelinating polyneuropathies. If sural sparing pattern specifically defined as absent/abnormal median and ulnar SNAP amplitude with normal sural SNAP amplitude (AMUNS) is sensitive and specific when compared with either absent/abnormal median and normal sural (AMNS) or absent/abnormal ulnar and normal sural (AUNS) for acute inflammatory demyelinating polyneuropathy (AIDP), chronic inflammatory demyelinating polyneuropathy (CIDP), select non-diabetic axonopathies (AXPs), and diabetic neuropathies (DNs). Retrospective analysis from 2001 to 2010 on all newly diagnosed AIDP, CIDP, select non-diabetic AXP, and DN. There were 20 AIDP and 23 CIDP. Twenty AXP and 50 DN patients between 2009 and 2010 were included as controls. AMUNS was seen in 65% of AIDP, 39% CIDP compared with 10% of AXP and 6% for DN with sensitivity of 51%, specificity of 92%, whereas the specificity of AMNS/AUNS was 73% and its sensitivity was 58%. If a patient has AMUNS they are >12 times more likely to have AIDP ( p  < 0.001). Sural sparing is highly specific but not sensitive when compared with either AMNS or AUNS in AIDP but does not add to sensitivity or specificity in CIDP.

Loss of a membrane trafficking protein αSNAP induces non-canonical autophagy in human epithelia

PubMed Central

Naydenov, Nayden G.; Harris, Gianni; Morales, Victor; Ivanov, Andrei I.

2012-01-01

Autophagy is a catabolic process that sequesters intracellular proteins and organelles within membrane vesicles called autophagosomes with their subsequent delivery to lyzosomes for degradation. This process involves multiple fusions of autophagosomal membranes with different vesicular compartments; however, the role of vesicle fusion in autophagosomal biogenesis remains poorly understood. This study addresses the role of a key vesicle fusion regulator, soluble N-ethylmaleimide-sensitive factor attachment protein α (αSNAP), in autophagy. Small interfering RNA-mediated downregulation of αSNAP expression in cultured epithelial cells stimulated the autophagic flux, which was manifested by increased conjugation of microtubule-associated protein light chain 3 (LC3-II) and accumulation of LC3-positive autophagosomes. This enhanced autophagy developed via a non-canonical mechanism that did not require beclin1-p150-dependent nucleation, but involved Atg5 and Atg7-mediated elongation of autophagosomal membranes. Induction of autophagy in αSNAP-depleted cells was accompanied by decreased mTOR signaling but appeared to be independent of αSNAP-binding partners, N-ethylmaleimide-sensitive factor and BNIP1. Loss of αSNAP caused fragmentation of the Golgi and downregulation of the Golgi-specific GTP exchange factors, GBF1, BIG1 and BIG2. Pharmacological disruption of the Golgi and genetic inhibition of GBF1 recreated the effects of αSNAP depletion on the autophagic flux. Our study revealed a novel role for αSNAP as a negative regulator of autophagy that acts by enhancing mTOR signaling and regulating the integrity of the Golgi complex. PMID:23187805

7 CFR 1962.14 - Account and security information in UCC cases.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 14 2013-01-01 2013-01-01 false Account and security information in UCC cases. 1962... Liquidation of Chattel Security § 1962.14 Account and security information in UCC cases. Within 2 weeks after... States, other parties, and also may lose some of its security rights. The UCC provides that the borrower...

7 CFR 1962.14 - Account and security information in UCC cases.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 14 2014-01-01 2014-01-01 false Account and security information in UCC cases. 1962... Liquidation of Chattel Security § 1962.14 Account and security information in UCC cases. Within 2 weeks after... States, other parties, and also may lose some of its security rights. The UCC provides that the borrower...

7 CFR 1962.14 - Account and security information in UCC cases.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 14 2011-01-01 2011-01-01 false Account and security information in UCC cases. 1962... Liquidation of Chattel Security § 1962.14 Account and security information in UCC cases. Within 2 weeks after... States, other parties, and also may lose some of its security rights. The UCC provides that the borrower...

7 CFR 1962.14 - Account and security information in UCC cases.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 14 2012-01-01 2012-01-01 false Account and security information in UCC cases. 1962... Liquidation of Chattel Security § 1962.14 Account and security information in UCC cases. Within 2 weeks after... States, other parties, and also may lose some of its security rights. The UCC provides that the borrower...

Strategies to Improve the Dietary Quality of Supplemental Nutrition Assistance Program (SNAP) Beneficiaries: An Assessment of Stakeholder Opinions

PubMed Central

Blumenthal, Susan J.; Hoffnagle, Elena E.; Leung, Cindy W.; Lofink, Hayley; Jensen, Helen H.; Foerster, Susan B.; Cheung, Lilian W.Y.; Nestle, Marion; Willet, Walter C.

2013-01-01

Objective To examine the opinions of stakeholders on strategies to improve dietary quality of Supplemental Nutrition Assistance Program (SNAP) participants. Design Participants answered a 38-item web-based survey assessing opinions and perceptions of SNAP and program policy changes. Setting U.S.A. Subjects Survey of 522 individuals with stakeholder interest in the Supplemental Nutrition Assistance Program (SNAP) conducted in October through December 2011. Results The top three barriers to improving dietary quality identified were: 1) unhealthy foods marketed in low-income communities; 2) the high cost of healthy foods; and 3) lifestyle challenges faced by low-income individuals. Many respondents (70%) also disagreed that current SNAP benefit levels were adequate to maintain a healthy diet. Stakeholders believed that vouchers, coupons, or monetary incentives for purchasing healthful foods might have the greatest potential for improving the diets of SNAP participants. Many respondents (78%) agreed that sodas should not be eligible for purchases with SNAP benefits. More than half (55%) believed retailers could easily implement such restrictions. A majority of respondents (58%) agreed that stores should stock a minimum quantity of healthful foods in order to be certified as a SNAP retailer, and most respondents (83%) believed that the USDA should collect data on the foods purchased with SNAP benefits. Conclusions Results suggest that there is broad stakeholder support for policies that align SNAP purchase eligibility with national public health goals of reducing food insecurity, improving nutrition and preventing obesity. PMID:24476898

SNAP Participants’ Eating Patterns over the Benefit Month: A Time Use Perspective

PubMed Central

2016-01-01

Individuals receiving monthly benefits through the U.S. Supplemental Nutrition Assistance Program (SNAP) often fall short of food at the end of the month and some report feelings of hunger. To investigate this situation, we used time diaries from the 2006–08 American Time Use Survey and Eating & Health Module to identify the timing of days where respondents reported no eating occurrences. Analysis includes descriptive statistics, a logit model, and a simulated benefit month. We found that SNAP participants were increasingly more likely than nonparticipants to report a day with no eating occurrences over the benefit issuance cycle. This supports the view that there is a monthly cycle in food consumption associated with the SNAP monthly benefit issuance policy. PMID:27410962

Method for reducing snap in magnetic amplifiers

NASA Technical Reports Server (NTRS)

Fischer, R. L. E.; Word, J. L.

1968-01-01

Method of reducing snap in magnetic amplifiers uses a degenerative feedback circuit consisting of a resistor and a separate winding on a magnetic core. The feedback circuit extends amplifier range by allowing it to be used at lower values of output current.

Beyond velocity and acceleration: jerk, snap and higher derivatives

NASA Astrophysics Data System (ADS)

Eager, David; Pendrill, Ann-Marie; Reistad, Nina

2016-11-01

The higher derivatives of motion are rarely discussed in the teaching of classical mechanics of rigid bodies; nevertheless, we experience the effect not only of acceleration, but also of jerk and snap. In this paper we will discuss the third and higher order derivatives of displacement with respect to time, using the trampolines and theme park roller coasters to illustrate this concept. We will also discuss the effects on the human body of different types of acceleration, jerk, snap and higher derivatives, and how they can be used in physics education to further enhance the learning and thus the understanding of classical mechanics concepts.

7 CFR 1962.14 - Account and security information in UCC cases.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 14 2010-01-01 2009-01-01 true Account and security information in UCC cases. 1962.14... Security § 1962.14 Account and security information in UCC cases. Within 2 weeks after receipt of a written... the information, it may be liable for any loss caused the borrower and, in some States, other parties...

The mobility of food retailers: How proximity to SNAP authorized food retailers changed in Atlanta during the Great Recession.

PubMed

Shannon, Jerry; Bagwell-Adams, Grace; Shannon, Sarah; Lee, Jung Sun; Wei, Yangjiaxin

2018-07-01

Retailer mobility, defined as the shifting geographic patterns of retail locations over time, is a significant but understudied factor shaping neighborhood food environments. Our research addresses this gap by analyzing changes in proximity to SNAP authorized chain retailers in the Atlanta urban area using yearly data from 2008 to 2013. We identify six demographically similar geographic clusters of census tracts in our study area based on race and economic variables. We use these clusters in exploratory data analysis to identify how proximity to the twenty largest retail food chains changed during this period. We then use fixed effects models to assess how changing store proximity is associated with race, income, participation in SNAP, and population density. Our results show clear differences in geographic distribution between store categories, but also notable variation within each category. Increasing SNAP enrollment predicted decreased distances to almost all small retailers but increased distances to many large retailers. Our chain-focused analysis underscores the responsiveness of small retailers to changes in neighborhood SNAP participation and the value of tracking chain expansion and contraction in markets across time. Better understanding of retailer mobility and the forces that drive it can be a productive avenue for future research. Copyright © 2018 Elsevier Ltd. All rights reserved.

Innovative, wearable snap connector technology for improved device networking in electronic garments

NASA Astrophysics Data System (ADS)

Kostrzewski, Andrew A.; Lee, Kang S.; Gans, Eric; Winterhalter, Carole A.; Jannson, Tomasz P.

2007-04-01

This paper discusses Physical Optics Corporation's (POC) wearable snap connector technology that provides for the transfer of data and power throughout an electronic garment (e-garment). These connectors resemble a standard garment button and can be mated blindly with only one hand. Fully compatible with military clothing, their application allows for the networking of multiple electronic devices and an intuitive method for adding/removing existing components from the system. The attached flexible cabling also permits the rugged snap connectors to be fed throughout the standard webbing found in military garments permitting placement in any location within the uniform. Variations of the snap electronics/geometry allow for integration with USB 2.0 devices, RF antennas, and are capable of transferring high bandwidth data streams such as the 221 Mbps required for VGA video. With the trend towards providing military officers with numerous electronic devices (i.e., heads up displays (HMD), GPS receiver, PDA, etc), POC's snap connector technology will greatly improve cable management resulting in a less cumbersome uniform. In addition, with electronic garments gaining widespread adoption in the commercial marketplace, POC's technology is finding applications in such areas as sporting good manufacturers and video game technology.

A Novel Candidate Gene for Temperature-Dependent Sex Determination in the Common Snapping Turtle.

PubMed

Schroeder, Anthony L; Metzger, Kelsey J; Miller, Alexandra; Rhen, Turk

2016-05-01

Temperature-dependent sex determination (TSD) was described nearly 50 years ago. Researchers have since identified many genes that display differential expression at male- vs. female-producing temperatures. Yet, it is unclear whether these genes (1) are involved in sex determination per se, (2) are downstream effectors involved in differentiation of ovaries and testes, or (3) are thermo-sensitive but unrelated to gonad development. Here we present multiple lines of evidence linking CIRBP to sex determination in the snapping turtle, Chelydra serpentina We demonstrate significant associations between a single nucleotide polymorphism (SNP) (c63A > C) in CIRBP, transcript levels in embryonic gonads during specification of gonad fate, and sex in hatchlings from a thermal regime that produces mixed sex ratios. The A allele was induced in embryos exposed to a female-producing temperature, while expression of the C allele did not differ between female- and male-producing temperatures. In accord with this pattern of temperature-dependent, allele-specific expression, AA homozygotes were more likely to develop ovaries than AC heterozygotes, which, in turn, were more likely to develop ovaries than CC homozygotes. Multiple regression using SNPs in CIRBP and adjacent loci suggests that c63A > C may be the causal variant or closely linked to it. Differences in CIRBP allele frequencies among turtles from northern Minnesota, southern Minnesota, and Texas reflect small and large-scale latitudinal differences in TSD pattern. Finally, analysis of CIRBP protein localization reveals that CIRBP is in a position to mediate temperature effects on the developing gonads. Together, these studies strongly suggest that CIRBP is involved in determining the fate of the bipotential gonad. Copyright © 2016 by the Genetics Society of America.

A Novel Candidate Gene for Temperature-Dependent Sex Determination in the Common Snapping Turtle

PubMed Central

Schroeder, Anthony L.; Metzger, Kelsey J.; Miller, Alexandra; Rhen, Turk

2016-01-01

Temperature-dependent sex determination (TSD) was described nearly 50 years ago. Researchers have since identified many genes that display differential expression at male- vs. female-producing temperatures. Yet, it is unclear whether these genes (1) are involved in sex determination per se, (2) are downstream effectors involved in differentiation of ovaries and testes, or (3) are thermo-sensitive but unrelated to gonad development. Here we present multiple lines of evidence linking CIRBP to sex determination in the snapping turtle, Chelydra serpentina. We demonstrate significant associations between a single nucleotide polymorphism (SNP) (c63A > C) in CIRBP, transcript levels in embryonic gonads during specification of gonad fate, and sex in hatchlings from a thermal regime that produces mixed sex ratios. The A allele was induced in embryos exposed to a female-producing temperature, while expression of the C allele did not differ between female- and male-producing temperatures. In accord with this pattern of temperature-dependent, allele-specific expression, AA homozygotes were more likely to develop ovaries than AC heterozygotes, which, in turn, were more likely to develop ovaries than CC homozygotes. Multiple regression using SNPs in CIRBP and adjacent loci suggests that c63A > C may be the causal variant or closely linked to it. Differences in CIRBP allele frequencies among turtles from northern Minnesota, southern Minnesota, and Texas reflect small and large-scale latitudinal differences in TSD pattern. Finally, analysis of CIRBP protein localization reveals that CIRBP is in a position to mediate temperature effects on the developing gonads. Together, these studies strongly suggest that CIRBP is involved in determining the fate of the bipotential gonad. PMID:26936926

Concentration of Tobacco Advertisements at SNAP and WIC Stores, Philadelphia, Pennsylvania, 2012

PubMed Central

Chilton, Mariana; Zhao, Qian-Wei; Szymkowiak, Dorota; Coffman, Ryan; Mallya, Giridhar

2015-01-01

Introduction Tobacco advertising is widespread in urban areas with racial/ethnic minority and low-income households that participate in nutrition assistance programs. Tobacco sales and advertising are linked to smoking behavior, which may complicate matters for low-income families struggling with disparate health risks relating to nutrition and chronic disease. We investigated the relationship between the amount and type of tobacco advertisements on tobacco outlets and the outlet type and location. Methods By using field visits and online images, we inspected all licensed tobacco retail outlets in Philadelphia (N = 4,639). Point pattern analyses were used to identify significant clustering of tobacco outlets and outlets with exterior tobacco advertisements. Logistic regression was used to analyze the relationship between the outlet’s acceptance of Supplemental Nutrition Assistance Program (SNAP) and Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) and the presence of tobacco advertisements. Results Tobacco outlets with exterior tobacco advertisements were significantly clustered in several high-poverty areas. Controlling for racial/ethnic and income composition and land use, SNAP and WIC vendors were significantly more likely to have exterior (SNAP odds ratio [OR], 2.11; WIC OR, 1.59) and interior (SNAP OR, 3.43; WIC OR, 1.69) tobacco advertisements than other types of tobacco outlets. Conclusion Tobacco advertising is widespread at retail outlets, particularly in low-income and racial/ethnic minority neighborhoods. Policy makers may be able to mitigate the effects of this disparate exposure through tobacco retail licensing, local sign control rules, and SNAP and WIC authorization. PMID:25654220

SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer's disease.

PubMed

Brinkmalm, Ann; Brinkmalm, Gunnar; Honer, William G; Frölich, Lutz; Hausner, Lucrezia; Minthon, Lennart; Hansson, Oskar; Wallin, Anders; Zetterberg, Henrik; Blennow, Kaj; Öhrfelt, Annika

2014-11-23

Synaptic degeneration is an early pathogenic event in Alzheimer's disease, associated with cognitive impairment and disease progression. Cerebrospinal fluid biomarkers reflecting synaptic integrity would be highly valuable tools to monitor synaptic degeneration directly in patients. We previously showed that synaptic proteins such as synaptotagmin and synaptosomal-associated protein 25 (SNAP-25) could be detected in pooled samples of cerebrospinal fluid, however these assays were not sensitive enough for individual samples. We report a new strategy to study synaptic pathology by using affinity purification and mass spectrometry to measure the levels of the presynaptic protein SNAP-25 in cerebrospinal fluid. By applying this novel affinity mass spectrometry strategy on three separate cohorts of patients, the value of SNAP-25 as a cerebrospinal fluid biomarker for synaptic integrity in Alzheimer's disease was assessed for the first time. We found significantly higher levels of cerebrospinal fluid SNAP-25 fragments in Alzheimer's disease, even in the very early stages, in three separate cohorts. Cerebrospinal fluid SNAP-25 differentiated Alzheimer's disease from controls with area under the curve of 0.901 (P < 0.0001). We developed a sensitive method to analyze SNAP-25 levels in individual CSF samples that to our knowledge was not possible previously. Our results support the notion that synaptic biomarkers may be important tools for early diagnosis, assessment of disease progression, and to monitor drug effects in treatment trials.

Chromophore-assisted laser inactivation of alpha- and gamma-tubulin SNAP-tag fusion proteins inside living cells.

PubMed

Keppler, Antje; Ellenberg, Jan

2009-02-20

Chromophore-assisted laser inactivation (CALI) can help to unravel localized activities of target proteins at defined times and locations within living cells. Covalent SNAP-tag labeling of fusion proteins with fluorophores such as fluorescein is a fast and highly specific tool to attach the photosensitizer to its target protein in vivo for selective inactivation of the fusion protein. Here, we demonstrate the effectiveness and specificity of SNAP-tag-based CALI by acute inactivation of alpha-tubulin and gamma-tubulin SNAP-tag fusions during live imaging assays of cell division. Singlet oxygen is confirmed as the reactive oxygen species that leads to loss of fusion protein function. The major advantage of SNAP-tag CALI is the ease, reliability, and high flexibility in labeling: the genetically encoded protein tag can be covalently labeled with various dyes matching the experimental requirements. This makes SNAP-tag CALI a very useful tool for rapid inactivation of tagged proteins in living cells.

α-SNAP interferes with the zippering of the SNARE protein membrane fusion machinery.

PubMed

Park, Yongsoo; Vennekate, Wensi; Yavuz, Halenur; Preobraschenski, Julia; Hernandez, Javier M; Riedel, Dietmar; Walla, Peter Jomo; Jahn, Reinhard

2014-06-06

Neuronal exocytosis is mediated by soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins. Before fusion, SNARE proteins form complexes bridging the membrane followed by assembly toward the C-terminal membrane anchors, thus initiating membrane fusion. After fusion, the SNARE complex is disassembled by the AAA-ATPase N-ethylmaleimide-sensitive factor that requires the cofactor α-SNAP to first bind to the assembled SNARE complex. Using chromaffin granules and liposomes we now show that α-SNAP on its own interferes with the zippering of membrane-anchored SNARE complexes midway through the zippering reaction, arresting SNAREs in a partially assembled trans-complex and preventing fusion. Intriguingly, the interference does not result in an inhibitory effect on synaptic vesicles, suggesting that membrane properties also influence the final outcome of α-SNAP interference with SNARE zippering. We suggest that binding of α-SNAP to the SNARE complex affects the ability of the SNARE complex to harness energy or transmit force to the membrane. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Chemical Processing Department monthly report, October 1962

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1962-11-21

This report, from the Chemical Processing Department at HAPO, for October, 1962 discusses the following: Production operation; Purex and Redox operation; Finished products operation; maintenance; Financial operations; facilities engineering; research; employee relations; and weapons manufacturing operation.

SNAP (Space Nuclear Auxiliary Power) reactor overview. Final report, June 1982-December 1983

DOE Office of Scientific and Technical Information (OSTI.GOV)

Voss, S.S.

1984-08-01

The SNAP reactor programs are outlined in this report. A summary of the program is included along with a technical outline of the SER, S2DR, SNAP 10A/SNAPSHOT, S8ER, and S8DR reactor systems. Specifications of the designs, the design logic and a conclusion outlining some of the program weaknesses are given.

SNAP 10A ESTIMATED ELECTRICAL CHARACTERISTICS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cooper, J.C.

1961-06-01

The electrical power characteristics of a SNAP 10A converter are estimated for given fractions of power degradation. Graphs are included showing the power characteristics for instantaneous transients from stabilized operation at the maximum efficiency point, and after system temperature stabilization at the operating point. Open-circuit emf's of the converter are estimated for instantaneous and temperature-stabilized cases. (D.L.C.)

The Relationship Between Obesity and Participation in the Supplemental Nutrition Assistance Program (SNAP): Is Mental Health a Mediator?

PubMed

Chaparro, M Pia; Harrison, Gail G; Pebley, Anne R; Wang, May

2014-10-01

Focusing on adults from the Los Angeles Family and Neighborhood Survey, we investigated whether mental health was a mediator in the association between obesity (body mass index ≥ 30 kg/m 2 ) and participation in the Supplemental Nutrition Assistance Program (SNAP). The analyses included 1776 SNAP participants and eligible nonparticipants. SNAP participants had higher odds of obesity (odds ratio [OR] =2.6; 95% confidence interval [CI], 1.52-4.36) and of reporting a mental health problem (OR = 3.8; 95% CI, 1.68-8.44) than eligible nonparticipants; however, mental health was not a mediator in the association between SNAP participation and obesity. We recommend changes in SNAP to promote healthier food habits among participants and reduce the stress associated with participation.

Quenched substrates for live-cell labeling of SNAP-tagged fusion proteins with improved fluorescent background.

PubMed

Stöhr, Katharina; Siegberg, Daniel; Ehrhard, Tanja; Lymperopoulos, Konstantinos; Öz, Simin; Schulmeister, Sonja; Pfeifer, Andrea C; Bachmann, Julie; Klingmüller, Ursula; Sourjik, Victor; Herten, Dirk-Peter

2010-10-01

Recent developments in fluorescence microscopy raise the demands for bright and photostable fluorescent tags for specific and background free labeling in living cells. Aside from fluorescent proteins and other tagging methods, labeling of SNAP-tagged proteins has become available thereby increasing the pool of potentially applicable fluorescent dyes for specific labeling of proteins. Here, we report on novel conjugates of benzylguanine (BG) which are quenched in their fluorescence and become highly fluorescent upon labeling of the SNAP-tag, the commercial variant of the human O(6)-alkylguanosyltransferase (hAGT). We identified four conjugates showing a strong increase, i.e., >10-fold, in fluorescence intensity upon labeling of SNAP-tag in vitro. Moreover, we screened a subset of nine BG-dye conjugates in living Escherichia coli and found them all suited for labeling of the SNAP-tag. Here, quenched BG-dye conjugates yield a higher specificity due to reduced contribution from excess conjugate to the fluorescence signal. We further extended the application of these conjugates by labeling a SNAP-tag fusion of the Tar chemoreceptor in live E. coli cells and the eukaryotic transcription factor STAT5b in NIH 3T3 mouse fibroblast cells. Aside from the labeling efficiency and specificity in living cells, we discuss possible mechanisms that might be responsible for the changes in fluorescence emission upon labeling of the SNAP-tag, as well as problems we encountered with nonspecific labeling with certain conjugates in eukaryotic cells.

Evaluating the diagnostic accuracy of Arabic SNAP test for children with hypernasality.

PubMed

Abou-Elsaad, Tamer; Afsah, Omayma; Baz, Hemmat; Mansy, Alzahraa

2016-06-01

Nasometry is a method of measuring the acoustic correlates of resonance through a computer-based instrument called nasometer. High nasalance scores in comparison to normative data suggest hypernasality and/or other nasality disorders, while low scores suggest hyponasality. Normative values of nasalance for Egyptian Arabic speakers were established using the Arabic SNAP (Simplified Nasometric Assessment Procedures) test. to evaluate the diagnostic accuracy of Arabic SNAP test to allow for its use in the differentiation between normal and hypernasal speech in Egyptian Arabic-speaking children. Nasalance scores of normal children (n=92) on Arabic SNAP test were compared to those of 30 children with velopharyngeal insufficiency due to cleft palate. Receiver operating characteristic (ROC) curve was used to determine cutoff points with the highest sensitivity and specificity. Statistically significant differences were found between both groups for all items in nasometric evaluation (p<0.05) except for prolonged/m/sound (p>0.05). Cutoff points were determined and certain items were selected for routine nasometric evaluation. The Arabic SNAP test is a sensitive and specific tool for evaluation of children with hypernasality and can be used for both diagnosis and follow up of these cases. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Contactless, photoinitiated snap-through in azobenzene-functionalized polymers

PubMed Central

Shankar, M. Ravi; Smith, Matthew L.; Tondiglia, Vincent P.; Lee, Kyung Min; McConney, Michael E.; Wang, David H.; Tan, Loon-Seng; White, Timothy J.

2013-01-01

Photomechanical effects in polymeric materials and composites transduce light into mechanical work. The ability to control the intensity, polarization, placement, and duration of light irradiation is a distinctive and potentially useful tool to tailor the location, magnitude, and directionality of photogenerated mechanical work. Unfortunately, the work generated from photoresponsive materials is often slow and yields very small power densities, which diminish their potential use in applications. Here, we investigate photoinitiated snap-through in bistable arches formed from samples composed of azobenzene-functionalized polymers (both amorphous polyimides and liquid crystal polymer networks) and report orders-of-magnitude enhancement in actuation rates (approaching 102 mm/s) and powers (as much as 1 kW/m3). The contactless, ultra-fast actuation is observed at irradiation intensities <<100 mW/cm2. Due to the bistability and symmetry of the snap-through, reversible and bidirectional actuation is demonstrated. A model is developed to elucidate the underlying mechanics of the snap-through, specifically focusing on isolating the role of sample geometry, mechanical properties of the materials, and photomechanical strain. Using light to trigger contactless, ultrafast actuation in an otherwise passive structure is a potentially versatile tool to use in mechanical design at the micro-, meso-, and millimeter scales as actuators, as well as switches that can be triggered from large standoff distances, impulse generators for microvehicles, microfluidic valves and mixers in laboratory-on-chip devices, and adaptive optical elements. PMID:24190994

Contactless, photoinitiated snap-through in azobenzene-functionalized polymers.

PubMed

Shankar, M Ravi; Smith, Matthew L; Tondiglia, Vincent P; Lee, Kyung Min; McConney, Michael E; Wang, David H; Tan, Loon-Seng; White, Timothy J

2013-11-19

Photomechanical effects in polymeric materials and composites transduce light into mechanical work. The ability to control the intensity, polarization, placement, and duration of light irradiation is a distinctive and potentially useful tool to tailor the location, magnitude, and directionality of photogenerated mechanical work. Unfortunately, the work generated from photoresponsive materials is often slow and yields very small power densities, which diminish their potential use in applications. Here, we investigate photoinitiated snap-through in bistable arches formed from samples composed of azobenzene-functionalized polymers (both amorphous polyimides and liquid crystal polymer networks) and report orders-of-magnitude enhancement in actuation rates (approaching 10(2) mm/s) and powers (as much as 1 kW/m(3)). The contactless, ultra-fast actuation is observed at irradiation intensities <100 mW/cm(2). Due to the bistability and symmetry of the snap-through, reversible and bidirectional actuation is demonstrated. A model is developed to elucidate the underlying mechanics of the snap-through, specifically focusing on isolating the role of sample geometry, mechanical properties of the materials, and photomechanical strain. Using light to trigger contactless, ultrafast actuation in an otherwise passive structure is a potentially versatile tool to use in mechanical design at the micro-, meso-, and millimeter scales as actuators, as well as switches that can be triggered from large standoff distances, impulse generators for microvehicles, microfluidic valves and mixers in laboratory-on-chip devices, and adaptive optical elements.

77 FR 16988 - Protection of Stratospheric Ozone: Amendment to HFO-1234yf SNAP Rule for Motor Vehicle Air...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-23

... Protection of Stratospheric Ozone: Amendment to HFO-1234yf SNAP Rule for Motor Vehicle Air Conditioning... hydrofluoroolefin (HFO)-1234yf (2,3,3,3-tetrafluoroprop-1-ene), a substitute for ozone- depleting substances (ODSs... EPA's Stratospheric Ozone Web site at http://www.epa.gov/ozone/snap/regs . The full list of SNAP...

Blocking dephosphorylation at Serine 120 residue in t-SNARE SNAP-23 leads to massive inhibition in exocytosis from mast cells.

PubMed

Naskar, Pieu; Naqvi, Nilofer; Puri, Niti

2018-03-01

Mast cells (MCs) respond to allergen challenge by release of pre-stored inflammatory mediators from their secretory granules, on cross-linking of Fc(epsilon) receptor I (Fc(epsilon)RI) receptors. The target-SNARE (t-SNARE) SNAP-23 has been shown to play an important role in MC exocytosis and undergoes transient phosphorylation at Serine 95 (S95) and Serine 120 (S120), concomitant with mediator release. During current study we explored the importance of transient nature of phosphorylation at S120 in MC exocytosis. A phosphomimetic SNAP-23-S120D mutant of rodent SNAP-23 was cloned into EGFP vector and its effect on the exocytosis and the mechanisms involved was studied in RBL-2H3 MC line. Secretion reporter assay with SNAP-23-S120D transfected MCs revealed a very significant inhibition of exocytosis, and reduced ruffling in response to Fc(epsilon)RI cross-linking. Further, the effect of this mutation on localization of SNAP-23 in MCs was studied. Immunofluorescence microscopy studies and membrane-cytosol fractionation of green fluorescent protein-tagged SNAP- 23-S120D (GFP-SNAP-23-S120D) transfected MCs showed that a large proportion of GFP-SNAP-23-S120D was residing in cytosol unlike wild-type SNAP-23, in resting and activated MCs and even the membrane associated portion was on internal lysosomal membranes than plasma membrane. These studies imply that dephosphorylation of S120 is important for SNAP-23 membrane association dynamics and subsequently MC degranulation.

7 CFR 1962.46 - Deceased borrowers.

Code of Federal Regulations, 2010 CFR

2010-01-01

... include costs of administration of the estate, allowable funeral expenses, allowances of minor children... will request OGC to effect collection if the proceeds from the sale of security are insufficient to pay...) The amount to be assumed and the repayment rates and terms will be the same as provided in § 1962.34(a...

The Education of the Whole Person or the Development of a Fortress Mentality?: Carmel College, Carmel: 1960-1962

ERIC Educational Resources Information Center

Godfrey, John R.

2005-01-01

This paper examines the religious, educational and social environment of Carmel College, Western Australia during the years 1960 to 1962 to ascertain whether the rhetoric matched the reality of the education offered to the Seventh-day Adventist students during these years, Carmel College was a co-educational Year 8 to 12 institution with an…

Validation of questionnaire on the Spiritual Needs Assessment for Patients (SNAP) questionnaire in Brazilian Portuguese

PubMed Central

de Araujo Toloi, Diego; Uema, Deise; Matsushita, Felipe; da Silva Andrade, Paulo Antonio; Branco, Tiago Pugliese; de Carvalho Chino, Fabiana Tomie Becker; Guerra, Raquel Bezerra; Pfiffer, Túlio Eduardo Flesch; Chiba, Toshio; Guindalini, Rodrigo Santa Cruz; Sulmasy, Daniel P; Riechelmann, Rachel P

2016-01-01

Summary Objectives Spirituality is related to the care and the quality of life of cancer patients. Thus, it is very important to assess their needs. The objective of this study was the translation and cultural adjustment of the Spiritual Needs Assessment for Patients (SNAP) questionnaire to the Brazilian Portuguese language. Methodology The translation and cultural adjustment of the SNAP questionnaire involved six stages: backtranslation, revision of backtranslation, translation to the original language and adjustments, pre-test on ten patients, and test and retest with 30 patients after three weeks. Adult patients, with a solid tumour and literate with a minimum of four years schooling were included. For analysis and consistency we used the calculation of the Cronbach alpha coefficient and the Pearson linear correlation. Results The final questionnaire had some language and content adjustments compared to the original version in English. The correlation analysis of each item with the total score of the questionnaire showed coefficients above 0.99. The calculation of the Cronbach alpha coefficient was 0.9. The calculation of the Pearson linear correlation with the test and retest of the questionnaire was equal to 0.95. Conclusion The SNAP questionnaire translated into Brazilian Portuguese is adequately reliable and consistent. This instrument allows adequate access to spiritual needs and can help patient care. PMID:28101137

Dismantlement of the TSF-SNAP Reactor Assembly

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peretz, Fred J

2009-01-01

This paper describes the dismantlement of the Tower Shielding Facility (TSF)?Systems for Nuclear Auxiliary Power (SNAP) reactor, a SNAP-10A reactor used to validate radiation source terms and shield performance models at Oak Ridge National Laboratory (ORNL) from 1967 through 1973. After shutdown, it was placed in storage at the Y-12 National Security Complex (Y-12), eventually falling under the auspices of the Highly Enriched Uranium (HEU) Disposition Program. To facilitate downblending of the HEU present in the fuel elements, the TSF-SNAP was moved to ORNL on June 24, 2006. The reactor assembly was removed from its packaging, inspected, and the sodium-potassiummore » (NaK) coolant was drained. A superheated steam process was used to chemically react the residual NaK inside the reactor assembly. The heat exchanger assembly was removed from the top of the reactor vessel, and the criticality safety sleeve was exchanged for a new safety sleeve that allowed for the removal of the vessel lid. A chain-mounted tubing cutter was used to separate the lid from the vessel, and the 36 fuel elements were removed and packaged in four U.S. Department of Transportation 2R/6M containers. The fuel elements were returned to Y-12 on July 13, 2006. The return of the fuel elements and disposal of all other reactor materials accomplished the formal objectives of the dismantlement project. In addition, a project model was established for the handling of a fully fueled liquid-metal?cooled reactor assembly. Current criticality safety codes have been benchmarked against experiments performed by Atomics International in the 1950s and 1960s. Execution of this project provides valuable experience applicable to future projects addressing space and liquid-metal-cooled reactors.« less

Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila.

PubMed

Morelli, Elena; Ginefra, Pierpaolo; Mastrodonato, Valeria; Beznoussenko, Galina V; Rusten, Tor Erik; Bilder, David; Stenmark, Harald; Mironov, Alexandre A; Vaccari, Thomas

2014-01-01

How autophagic degradation is linked to endosomal trafficking routes is little known. Here we screened a collection of uncharacterized Drosophila mutants affecting membrane transport to identify new genes that also have a role in autophagy. We isolated a loss of function mutant in Snap29 (Synaptosomal-associated protein 29 kDa), the gene encoding the Drosophila homolog of the human protein SNAP29 and have characterized its function in vivo. Snap29 contains 2 soluble NSF attachment protein receptor (SNARE) domains and a asparagine-proline-phenylalanine (NPF motif) at its N terminus and rescue experiments indicate that both SNARE domains are required for function, whereas the NPF motif is in part dispensable. We find that Snap29 interacts with SNARE proteins, localizes to multiple trafficking organelles, and is required for protein trafficking and for proper Golgi apparatus morphology. Developing tissue lacking Snap29 displays distinctive epithelial architecture defects and accumulates large amounts of autophagosomes, highlighting a major role of Snap29 in autophagy and secretion. Mutants for autophagy genes do not display epithelial architecture or secretion defects, suggesting that the these alterations of the Snap29 mutant are unlikely to be caused by the impairment of autophagy. In contrast, we find evidence of elevated levels of hop-Stat92E (hopscotch-signal transducer and activator of transcription protein at 92E) ligand, receptor, and associated signaling, which might underlie the epithelial defects. In summary, our findings support a role of Snap29 at key steps of membrane trafficking, and predict that signaling defects may contribute to the pathogenesis of cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma (CEDNIK), a human congenital syndrome due to loss of Snap29.

Snap-buckling in asymmetrically constrained elastic strips

NASA Astrophysics Data System (ADS)

Sano, Tomohiko G.; Wada, Hirofumi

2018-01-01

When a flat elastic strip is compressed along its axis, it is bent in one of two possible directions via spontaneous symmetry breaking, forming a cylindrical arc. This is a phenomenon well known as Euler buckling. When this cylindrical section is pushed in the other direction, the bending direction can suddenly reverse. This instability is called "snap-through buckling" and is one of the elementary shape transitions in a prestressed thin structure. Combining experiments and theory, we study snap-buckling of an elastic strip with one end hinged and the other end clamped. These asymmetric boundary constraints break the intrinsic symmetry of the strip, generating mechanical behaviors, including largely hysteretic but reproducible force responses and switchlike discontinuous shape changes. We establish the set of exact analytical solutions to fully explain all our major experimental and numerical findings. Asymmetric boundary conditions arise naturally in diverse situations when a thin object is in contact with a solid surface at one end. The introduction of asymmetry through boundary conditions yields new insight into complex and programmable functionalities in material and industrial design.

Questions and Answers About SNAP Alternatives in Each Sector

EPA Pesticide Factsheets

The following list of questions and answers provides an overview of the regulations governing the use of substitutes that are reviewed under the Significant New Alternatives Policy (SNAP) program in various industrial sectors.

Select putative neurodevelopmental toxins modify SNAP-25 expression in primary cultures of rat cerebellar granule cells.

PubMed

Zieminska, Elzbieta; Lenart, Jacek; Lazarewicz, Jerzy W

2016-08-31

A presynaptic protein SNAP-25 belonging to SNARE complex which is instrumental in intracellular vesicular trafficking and exocytosis, has been implicated in hyperactivity and cognitive abilities in some neuropsychiatric disorders. The unclear etiology of the behavior disrupting neurodevelopmental disabilities in addition to genetic causes most likely involves environmental factors. The aim of this in vitro study was to test if various suspected developmental neurotoxins can alter SNAP-25 mRNA and protein expression in neurons. Real-time PCR and Western blotting analyses were used to assess SNAP-25 mRNA and protein levels in primary cultures of rat cerebellar granule cells (CGCs). The test substances: tetrabromobisphenol-A (TBBPA), thimerosal (TH), silver nanoparticles (NAg), valproic acid (VPA) and thalidomide (THAL), were administered to CGC cultures at subtoxic concentrations for 24h. The results demonstrated that SNAP-25 mRNA levels were increased by 49 and 66% by TBBPA and THAL, respectively, whereas VPA and NAg reduced these levels to 48 and 64% of the control, respectively. The SNAP-25 protein content in CGCs was increased by 79% by TBBPA, 25% by THAL and 21% by NAg; VPA and TH reduced these levels to 73 and 69% of the control, respectively. The variety of changes in SNAP-25 expression on mRNA and protein level suggests the diversity of the mechanism of action of the test substances. This initial study provided no data on concentration-effect relations and on functional changes in CGCs. However it is the first to demonstrate the effect of different compounds that are suspected of causing neurodevelopmental disabilities on SNAP-25 expression. These results suggest that this protein may be a common target for not only inherited but also environmental modifications linked to behavioral deficits in neurodevelopmental disabilities. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

The Tragic Bazooka Accident at Los Alamos on July 14, 1962

DOE Office of Scientific and Technical Information (OSTI.GOV)

Skidmore, Cary Bradford

In recent years the Laboratory has made information (documents, photographs, and perspectives) regarding the occupational explosives accidents that killed seven men in the late 1950s more accessible to the public. While pursuing this effort, we were reminded of similar tragedies that occurred to children of the community. The purpose of this paper is to make information that has come into our hands more available to the public regarding these accidents. Following this introduction, a brief synopsis is provided for each accident. The appendices contain source documents for the 1962 accident that are not generally available. The community of Los Alamos,more » New Mexico was born out of a military post created to support the secret Manhattan Project during World War II. Security was provided by military police and some training exercises were conducted using live ordnance. In two instances unexploded ordnance (UXO) from this era was found “in the field” by residents hiking in the local area and brought into town. Tragically, handling these “bazooka” rounds as “dud” munitions resulted in death for one child and injury to several others. The first accident occurred on Saturday, September 6, 1947, which resulted in injuries to two boys, ages 5 and 12. The second accident occurred on Saturday, July 14, 1962 and resulted in the death of one five-year-old boy, and injuries to four other children, ages 6 to 10 years-old. The latter accident is the primary focus of the paper.« less

A Biomechanical Comparison of the Long Snap in Football Between High School and University Football Players.

PubMed

Chizewski, Michael G; Alexander, Marion J L

2015-08-01

Limited previous research was located that examined the technique of the long snap in football. The purpose of the study was to compare the joint movements, joint velocities, and body positions used to perform fast and accurate long snaps in high school (HS) and university (UNI) athletes. Ten HS and 10 UNI subjects were recruited for filming, each performing 10 snaps at a target with the fastest and most accurate trial being selected for subject analysis. Eighty-three variables were measured using Dartfish Team Pro 4.5.2 video analysis software, with statistical analysis performed using Microsoft Excel and SPSS 16.0. Several significant comparisons to long snapping technique between groups were noted during analysis; however, the body position and movement variables at release showed the greatest number of significant differences. The UNI athletes demonstrated significantly higher release velocity and left elbow extension velocity, with significantly lower release height and release angle than the HS group. Total snap time (release time + total flight time) was determined to have the strongest correlation to release velocity for the HS group (r = -0.915) and UNI group (r = -0.918). The study suggests HS long snappers may benefit from less elbow flexion and more knee flexion in the backswing (set position) to increase release velocity. University long snappers may benefit from increased left elbow extension range of motion during force production and decreased shoulder flexion at critical instant to increase long snap release velocity.

SNAP-8 power conversion system design review

NASA Technical Reports Server (NTRS)

Lopez, L. P.

1970-01-01

The conceptual design of the SNAP-8 electrical generating system configurations are reviewed including the evolution of the PCS configuration, and the current concepts. The reliabilities of two alternative PCS-G heat rejection loop configurations with two radiator design concepts are also reviewed. A computer program for calculating system pressure loss using multiple-loop flow analysis is included.

A Simple Snap Oscillator with Coexisting Attractors, Its Time-Delayed Form, Physical Realization, and Communication Designs

NASA Astrophysics Data System (ADS)

Rajagopal, Karthikeyan; Jafari, Sajad; Akgul, Akif; Karthikeyan, Anitha; Çiçek, Serdar; Shekofteh, Yasser

2018-05-01

In this paper, we report a novel chaotic snap oscillator with one nonlinear function. Dynamic analysis of the system shows the existence of bistability. To study the time delay effects on the proposed snap oscillator, we introduce multiple time delay in the fourth state equation. Investigation of dynamical properties of the time-delayed system shows that the snap oscillator exhibits the same multistable properties as the nondelayed system. The new multistable hyperjerk chaotic system has been tested in chaos shift keying and symmetric choc shift keying modulated communication designs for engineering applications. It has been determined that the symmetric chaos shift keying modulated communication system implemented with the new chaotic system is more successful than the chaos shift keying modulation for secure communication. Also, circuit implementation of the chaotic snap oscillator with tangent function is carried out showing its feasibility.

Hanford Laboratories Operation monthly activities report, November 1962

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1962-12-14

This is the monthly report for the Hanford Laboratories Operation, November 1962. Metallurgy, reactor fuels, chemistry, dosimetry, separation processes, reactor technology, financial activities, visits, biology operation, physics and instrumentation research, and employee relations are discussed.

Creating a Minnesota Statewide SNAP-Ed Program Evaluation

ERIC Educational Resources Information Center

Gold, Abby; Barno, Trina Adler; Sherman, Shelley; Lovett, Kathleen; Hurtado, G. Ali

2013-01-01

Systematic evaluation is an essential tool for understanding program effectiveness. This article describes the pilot test of a statewide evaluation tool for the Supplemental Nutrition Assistance Program-Education (SNAP-Ed). A computer algorithm helped Community Nutrition Educators (CNEs) build surveys specific to their varied educational settings…

NREL Engineers Look for a Cool Way to Make AC Units an Affordable Snap |

Science.gov Websites

installing the components of the EcoSnap-AC. Photo by Dennis Schroeder Engineers Chuck Booten and Jon Winkler Booten drills a hole in the wall to mount the EcoSnap-AC. Photo by Dennis Schroeder The Evolution of an , and eliminating air leaks and water intrusion. Photo by Dennis Schroeder Looking Ahead to a Cooler

Habitat Suitability Index Models: Snapping turtle

USGS Publications Warehouse

Graves, Brent M.; Anderson, Stanley H.

1987-01-01

A review and synthesis of existing information were used to develop a Habitat Suitability Index (HSI) model for the snapping turtle (Chelydra serpentina). The model consolidates habitat use information into a framework appropriate for field application, and is scaled to produce an index between 0.0 (unsuitable habitat) and 1.0 (optimum habitat). HSI models are designed to be used with Habitat Evaluation Procedures previously developed by the U.S. Fish and Wildlife Service.

Obituary: ESO Astronomer, Alphonse Florsch (Zeekoegat 1962)

NASA Astrophysics Data System (ADS)

Swanepoel, Eric

2015-10-01

In June 1962 Alphonse Florsch, his wife Marguerite and their two sons Bruno (7) and Nicolas (5), came from France to work at the European Southern Observatory (ESO) at Zeekoegat (Florsch 2005-2006). This was during the time of site testing to find the best location for ESO.

Associations between food insecurity, supplemental nutrition assistance program (SNAP) benefits, and body mass index among adult females.

PubMed

Jilcott, Stephanie B; Wall-Bassett, Elizabeth D; Burke, Sloane C; Moore, Justin B

2011-11-01

Obesity disproportionately affects low-income and minority individuals and has been linked with food insecurity, particularly among women. More research is needed to examine potential mechanisms linking obesity and food insecurity. Therefore, this study's purpose was to examine cross-sectional associations between food insecurity, Supplemental Nutrition Assistance Program (SNAP) benefits per household member, perceived stress, and body mass index (BMI) among female SNAP participants in eastern North Carolina (n=202). Women were recruited from the Pitt County Department of Social Services between October 2009 and April 2010. Household food insecurity was measured using the validated US Department of Agriculture 18-item food security survey module. Perceived stress was measured using the 14-item Cohen's Perceived Stress Scale. SNAP benefits and number of children in the household were self-reported and used to calculate benefits per household member. BMI was calculated from measured height and weight (as kg/m(2)). Multivariate linear regression was used to examine associations between BMI, SNAP benefits, stress, and food insecurity while adjusting for age and physical activity. In adjusted linear regression analyses, perceived stress was positively related to food insecurity (P<0.0001), even when SNAP benefits were included in the model. BMI was positively associated with food insecurity (P=0.04). Mean BMI was significantly greater among women receiving <$150 in SNAP benefits per household member vs those receiving ≥$150 in benefits per household member (35.8 vs 33.1; P=0.04). Results suggest that provision of adequate SNAP benefits per household member might partially ameliorate the negative effects of food insecurity on BMI. Copyright © 2011 American Dietetic Association. Published by Elsevier Inc. All rights reserved.

SNAP-Based Incentive Programs at Farmers' Markets: Adaptation Considerations for Temporary Assistance for Needy Families (TANF) Recipients.

PubMed

Wetherill, Marianna S; Williams, Mary B; Gray, Karen A

2017-10-01

To describe the design, implementation, and consumer response to a coupon-style intervention aimed to increase Supplemental Nutrition Assistance Program (SNAP) use at a farmers' market (FM) among Temporary Assistance for Needy Families (TANF) participants. A quasi-experimental trial to evaluate redemption response to 2 coupon interventions; baseline surveys characterized coupon redeemers and non-redeemers. Urban. The TANF recipients were assigned to either a plain (n = 124) or targeted marketing coupon intervention (n = 130). Both groups received 10 $2 coupons to double fruit and vegetable SNAP purchases at the FM. The targeted marketing group also received an oral presentation designed to reduce perceived barriers to FM use. Coupon redemption. The researchers used t tests and chi-square/Fisher exact tests to examine associations between redeemers and non-redeemers; logistic regression was used to adjust for the intervention. No male and few female participants redeemed coupons (6.3%). Among women, those with knowledge of vegetable preparation were 3 times more likely to redeem coupons than were those with little or no knowledge (odds ratio = 3.77; 95% confidence interval, 1.03-13.77). Stand-alone coupon incentive programs may not be a high-reach strategy for encouraging FM use among the population using TANF. Complementary strategies to build vegetable preparation knowledge and skills are needed. Copyright © 2017 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

Maternal Rest/Nrsf Regulates Zebrafish Behavior through snap25a/b

PubMed Central

Moravec, Cara E.; Samuel, John; Weng, Wei; Wood, Ian C.

2016-01-01

During embryonic development, regulation of gene expression is key to creating the many subtypes of cells that an organism needs throughout its lifetime. Recent work has shown that maternal genetics and environmental factors have lifelong consequences on diverse processes ranging from immune function to stress responses. The RE1-silencing transcription factor (Rest) is a transcriptional repressor that interacts with chromatin-modifying complexes to repress transcription of neural-specific genes during early development. Here we show that in zebrafish, maternally supplied rest regulates expression of target genes during larval development and has lifelong impacts on behavior. Larvae deprived of maternal rest are hyperactive and show atypical spatial preferences. Adult male fish deprived of maternal rest present with atypical spatial preferences in a novel environment assay. Transcriptome sequencing revealed 158 genes that are repressed by maternal rest in blastula stage embryos. Furthermore, we found that maternal rest is required for target gene repression until at least 6 dpf. Importantly, disruption of the RE1 sites in either snap25a or snap25b resulted in behaviors that recapitulate the hyperactivity phenotype caused by absence of maternal rest. Both maternal rest mutants and snap25a RE1 site mutants have altered primary motor neuron architecture that may account for the enhanced locomotor activity. These results demonstrate that maternal rest represses snap25a/b to modulate larval behavior and that early Rest activity has lifelong behavioral impacts. SIGNIFICANCE STATEMENT Maternal factors deposited in the oocyte have well-established roles during embryonic development. We show that, in zebrafish, maternal rest (RE1-silencing transcription factor) regulates expression of target genes during larval development and has lifelong impacts on behavior. The Rest transcriptional repressor interacts with chromatin-modifying complexes to limit transcription of neural

Long-Term Nitric Oxide Release and Elevated Temperature Stability with S-Nitroso-N-acetylpenicillamine (SNAP)-Doped Elast-eon E2As Polymer

PubMed Central

Brisbois, Elizabeth J.; Handa, Hitesh; Major, Terry C.; Bartlett, Robert H.; Meyerhoff, Mark E.

2013-01-01

Nitric oxide (NO) is known to be a potent inhibitor of platelet activation and adhesion. Healthy endothelial cells that line the inner walls of all blood vessels exhibit a NO flux of 0.5~4×10−10 mol cm−2 min−1 that helps prevent thrombosis. Materials with a NO flux that is equivalent to this level are expected to exhibit similar anti-thrombotic properties. In this study, five biomedical grade polymers doped with S-nitroso-N-acetylpenicillamine (SNAP) were investigated for their potential to control the release of NO from the SNAP within the polymers, and further control the release of SNAP itself. SNAP in the Elast-eon E2As polymer creates an inexpensive, homogeneous coating that can locally deliver NO (via thermal and photochemical reactions) as well slowly release SNAP. Furthermore, SNAP is surprisingly stable in the E2As polymer, retaining 82% of the initial SNAP after 2 months storage at 37°C. The E2As polymer containing SNAP was coated on the walls of extracorporeal circuits (ECC) and exposed to 4 h blood flow in a rabbit model of extracorporeal circulation to examine the effects on platelet count, platelet function, clot area, and fibrinogen adsorption. After 4 h, platelet count was preserved at 100±7% of baseline for the SNAP/E2As coated loops, compared to 60±6% for E2As control circuits (n=4). The SNAP/E2As coating also reduced the thrombus area when compared to the control (2.3±0.6 and 3.4±1.1 pixels/cm2, respectively). The results suggest that the new SNAP/E2As coating has potential to improve the thromboresistance of intravascular catheters, grafts, and other blood contacting medical devices, and exhibits excellent storage stability compared to previously reported NO release polymeric materials. PMID:23777908

Severe Nuclear Accident Program (SNAP) - a real time model for accidental releases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saltbones, J.; Foss, A.; Bartnicki, J.

1996-12-31

The model: Several Nuclear Accident Program (SNAP) has been developed at the Norwegian Meteorological Institute (DNMI) in Oslo to provide decision makers and Government officials with real-time tool for simulating large accidental releases of radioactivity from nuclear power plants or other sources. SNAP is developed in the Lagrangian framework in which atmospheric transport of radioactive pollutants is simulated by emitting a large number of particles from the source. The main advantage of the Lagrangian approach is a possibility of precise parameterization of advection processes, especially close to the source. SNAP can be used to predict the transport and deposition ofmore » a radioactive cloud in e future (up to 48 hours, in the present version) or to analyze the behavior of the cloud in the past. It is also possible to run the model in the mixed mode (partly analysis and partly forecast). In the routine run we assume unit (1 g s{sup -1}) emission in each of three classes. This assumption is very convenient for the main user of the model output in case of emergency: Norwegian Radiation Protection Agency. Due to linearity of the model equations, user can test different emission scenarios as a post processing task by assigning different weights to concentration and deposition fields corresponding to each of three emission classes. SNAP is fully operational and can be run by the meteorologist on duty at any time. The output from SNAP has two forms: First on the maps of Europe, or selected parts of Europe, individual particles are shown during the simulation period. Second, immediately after the simulation, concentration/deposition fields can be shown every three hours of the simulation period as isoline maps for each emission class. In addition, concentration and deposition maps, as well as some meteorological data, are stored on a public accessible disk for further processing by the model users.« less

A Brief Description of the Kokkos implementation of the SNAP potential in ExaMiniMD.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, Aidan P.; Trott, Christian Robert

2017-11-01

Within the EXAALT project, the SNAP [1] approach is being used to develop high accuracy potentials for use in large-scale long-time molecular dynamics simulations of materials behavior. In particular, we have developed a new SNAP potential that is suitable for describing the interplay between helium atoms and vacancies in high-temperature tungsten[2]. This model is now being used to study plasma-surface interactions in nuclear fusion reactors for energy production. The high-accuracy of SNAP potentials comes at the price of increased computational cost per atom and increased computational complexity. The increased cost is mitigated by improvements in strong scaling that can bemore » achieved using advanced algorithms [3].« less

The running athlete: stress fractures, osteitis pubis, and snapping hips.

PubMed

Henning, P Troy

2014-03-01

Pelvic stress fractures, osteitis pubis, and snapping hip syndrome account for a portion of the overuse injuries that can occur in the running athlete. PUBMED SEARCHES WERE PERFORMED FOR EACH ENTITY USING THE FOLLOWING KEYWORDS: snapping hip syndrome, coxa sultans, pelvic stress fracture, and osteitis pubis from 2008 to 2013. Topic reviews, case reports, case series, and randomized trials were included for review. Clinical review. Level 4. Collectively, 188 articles were identified. Of these, 58 were included in this review. Based on the available evidence, the majority of these overuse injuries can be managed non-operatively. Primary treatment should include removal from offending activity, normalizing regional muscle strength/length imbalances and nutritional deficiencies, and mitigating training errors through proper education of the athlete and training staff. C.

The SNAP Platform: Social Networking for Academic Purposes

ERIC Educational Resources Information Center

Kirkwood, Keith

2010-01-01

Purpose: This paper aims to introduce an enterprise-wide Web 2.0 learning support platform--SNAP, developed at Victoria University in Melbourne, Australia. Design/methodology/approach: Pointing to the evolution of the social web, the paper discusses the potential for the development of e-learning platforms that employ constructivist, connectivist,…

Results of woodcock wing collections, 1959 to 1962

USGS Publications Warehouse

Martin, F.W.; Geis, A.D.; Stickel, W.H.

1965-01-01

During hunting seasons from 1959 to 1962, age and sex determined from 45,444 wings were used to measure annual productivity of woodcocks (Philohela minor). Age of birds was determined by pattern and color of secondaries and by wear on primaries. Sex was determined by width and length of primaries. Overall age ratios, weighted by kill estimates, were the same each year and indicated no change in annual productivity. Immature sex ratios in the combined kill were nearly even each year, but kill of adult females was much larger than kill of adult males. The difference in sex ratios between immatures and adults thus suggests higher mortality of males than females after the first hunting season. Since woodcocks are promiscuous, an unbalanced adult sex ratio in favor of females probably does not reduce productivity. There are, however, factors affecting reliability of information deduced from wing collections, and further research is necessary to answer questions on differential vulnerability and mortality rates.

Helminth infracommunities of the common snapping turtle (Chelydra serpentina serpentina) from Westhampton Lake, Virginia.

PubMed

Zelmer, Derek A; Platt, Thomas R

2009-12-01

Patterns of infracommunity similarity were examined for 27 male and 6 female common snapping turtles, Chelydra serpentina serpentina, collected from Westhampton Lake on the campus of the University of Richmond in Richmond, Virginia, during the summer months of 1979 and 1980. Patterns of infracommunity similarity based on parasite abundance emphasized differences between years and between host sexes. Patterns of similarity based on parasite presence or absence emphasized differences among the months sampled. This suggests that there were consistent seasonal changes across both years in terms of which parasites were present, but that there were differences between years in terms of the abundances of those parasites.

Reconceiving SNAP: Is Nutritional Assistance Really Income Support?

ERIC Educational Resources Information Center

Besharov, Douglas J.

2016-01-01

Since its creation, the Supplemental Nutrition Assistance Program (SNAP) has changed from an antihunger program to an income-supplementation program. Because the program (and its predecessor Food Stamp Program) was not designed for this purpose, the result is a program that has many unintended and, many believe, negative effects. The key challenge…

8-Nitro-cGMP Attenuates the Interaction between SNARE Complex and Complexin through S-Guanylation of SNAP-25.

PubMed

Kishimoto, Yusuke; Kunieda, Kohei; Kitamura, Atsushi; Kakihana, Yuki; Akaike, Takaaki; Ihara, Hideshi

2018-02-21

8-Nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP) is the second messenger in nitric oxide/reactive oxygen species redox signaling. This molecule covalently binds to protein thiol groups, called S-guanylation, and exerts various biological functions. Recently, we have identified synaptosomal-associated protein 25 (SNAP-25) as a target of S-guanylation, and demonstrated that S-guanylation of SNAP25 enhanced SNARE complex formation. In this study, we have examined the effects of S-guanylation of SNAP-25 on the interaction between the SNARE complex and complexin (cplx), which binds to the SNARE complex with a high affinity. Pull-down assays and coimmunoprecipitation experiments have revealed that S-guanylation of Cys90 in SNAP-25 attenuates the interaction between the SNARE complex and cplx. In addition, blue native-PAGE followed by Western blot analysis revealed that the amount of cplx detected at a high molecular weight decreased upon 8-nitro-cGMP treatment in SH-SY5Y cells. These results demonstrated for the first time that S-guanylation of SNAP-25 attenuates the interaction between the SNARE complex and cplx.

Small peptides patterned after the N-terminus domain of SNAP25 inhibit SNARE complex assembly and regulated exocytosis.

PubMed

Blanes-Mira, Clara; Merino, Jaime M; Valera, Elvira; Fernández-Ballester, Gregorio; Gutiérrez, Luis M; Viniegra, Salvador; Pérez-Payá, Enrique; Ferrer-Montiel, Antonio

2004-01-01

Synthetic peptides patterned after the C-terminus of synaptosomal associated protein of 25 kDa (SNAP25) efficiently abrogate regulated exocytosis. In contrast, the use of SNAP25 N-terminal-derived peptides to modulate SNAP receptors (SNARE) complex assembly and neurosecretion has not been explored. Here, we show that the N-terminus of SNAP25, specially the segment that encompasses 22Ala-44Ile, is essential for the formation of the SNARE complex. Peptides patterned after this protein domain are potent inhibitors of SNARE complex formation. The inhibitory activity correlated with their propensity to adopt an alpha-helical secondary structure. These peptides abrogated SNARE complex formation only when added previous to the onset of aggregate assembly. Analysis of the mechanism of action revealed that these peptides disrupted the binary complex formed by SNAP25 and syntaxin. The identified peptides inhibited Ca2+-dependent exocytosis from detergent-permeabilized excitable cells. Noteworthy, these amino acid sequences markedly protected intact hippocampal neurones against hypoglycaemia-induced, glutamate-mediated excitotoxicity with a potency that rivalled that displayed by botulinum neurotoxins. Our findings indicate that peptides patterned after the N-terminus of SNAP25 are potent inhibitors of SNARE complex formation and neuronal exocytosis. Because of their activity in intact neurones, these cell permeable peptides may be hits for antispasmodic and analgesic drug development.

A Multilevel Functional Study of a SNAP25 At-Risk Variant for Bipolar Disorder and Schizophrenia.

PubMed

Houenou, Josselin; Boisgontier, Jennifer; Henrion, Annabelle; d'Albis, Marc-Antoine; Dumaine, Anne; Linke, Julia; Wessa, Michèle; Daban, Claire; Hamdani, Nora; Delavest, Marine; Llorca, Pierre-Michel; Lançon, Christophe; Schürhoff, Franck; Szöke, Andrei; Le Corvoisier, Philippe; Barau, Caroline; Poupon, Cyril; Etain, Bruno; Leboyer, Marion; Jamain, Stéphane

2017-10-25

The synaptosomal-associated protein SNAP25 is a key player in synaptic vesicle docking and fusion and has been associated with multiple psychiatric conditions, including schizophrenia, bipolar disorder, and attention-deficit/hyperactivity disorder. We recently identified a promoter variant in SNAP25 , rs6039769 , that is associated with early-onset bipolar disorder and a higher gene expression level in human prefrontal cortex. In the current study, we showed that this variant was associated both in males and females with schizophrenia in two independent cohorts. We then combined in vitro and in vivo approaches in humans to understand the functional impact of the at-risk allele. Thus, we showed in vitro that the rs6039769 C allele was sufficient to increase the SNAP25 transcription level. In a postmortem expression analysis of 33 individuals affected with schizophrenia and 30 unaffected control subjects, we showed that the SNAP25b / SNAP25a ratio was increased in schizophrenic patients carrying the rs6039769 at-risk allele. Last, using genetics imaging in a cohort of 71 subjects, we showed that male risk carriers had an increased amygdala-ventromedial prefrontal cortex functional connectivity and a larger amygdala than non-risk carriers. The latter association has been replicated in an independent cohort of 121 independent subjects. Altogether, results from these multilevel functional studies are bringing strong evidence for the functional consequences of this allelic variation of SNAP25 on modulating the development and plasticity of the prefrontal-limbic network, which therefore may increase the vulnerability to both early-onset bipolar disorder and schizophrenia. SIGNIFICANCE STATEMENT Functional characterization of disease-associated variants is a key challenge in understanding neuropsychiatric disorders and will open an avenue in the development of personalized treatments. Recent studies have accumulated evidence that the SNARE complex, and more specifically

Exploring the association of urban or rural county status and environmental, nutrition- and lifestyle-related resources with the efficacy of SNAP-Ed (Supplemental Nutrition Assistance Program-Education) to improve food security.

PubMed

Rivera, Rebecca L; Dunne, Jennifer; Maulding, Melissa K; Wang, Qi; Savaiano, Dennis A; Nickols-Richardson, Sharon M; Eicher-Miller, Heather A

2018-04-01

To investigate the association of policy, systems and environmental factors with improvement in household food security among low-income Indiana households with children after a Supplemental Nutrition Assistance Program-Education (SNAP-Ed) direct nutrition education intervention. Household food security scores measured by the eighteen-item US Household Food Security Survey Module in a longitudinal randomized and controlled SNAP-Ed intervention study conducted from August 2013 to April 2015 were the response variable. Metrics to quantify environmental factors including classification of urban or rural county status; the number of SNAP-authorized stores, food pantries and recreational facilities; average fair market housing rental price; and natural amenity rank were collected from government websites and data sets covering the years 2012-2016 and used as covariates in mixed multiple linear regression modelling. Thirty-seven Indiana counties, USA, 2012-2016. SNAP-Ed eligible adults from households with children (n 328). None of the environmental factors investigated were significantly associated with changes in household food security in this exploratory study. SNAP-Ed improves food security regardless of urban or rural location or the environmental factors investigated. Expansion of SNAP-Ed in rural areas may support food access among the low-income population and reduce the prevalence of food insecurity in rural compared with urban areas. Further investigation into policy, systems and environmental factors of the Social Ecological Model are warranted to better understand their relationship with direct SNAP-Ed and their impact on diet-related behaviours and food security.

STATISTICAL ANALYSIS OF SNAP 10A THERMOELECTRIC CONVERTER ELEMENT PROCESS DEVELOPMENT VARIABLES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fitch, S.H.; Morris, J.W.

1962-12-15

Statistical analysis, primarily analysis of variance, was applied to evaluate several factors involved in the development of suitable fabrication and processing techniques for the production of lead telluride thermoelectric elements for the SNAP 10A energy conversion system. The analysis methods are described as to their application for determining the effects of various processing steps, estabIishing the value of individual operations, and evaluating the significance of test results. The elimination of unnecessary or detrimental processing steps was accomplished and the number of required tests was substantially reduced by application of these statistical methods to the SNAP 10A production development effort. (auth)

SnapDock—template-based docking by Geometric Hashing

PubMed Central

Estrin, Michael; Wolfson, Haim J.

2017-01-01

Abstract Motivation: A highly efficient template-based protein–protein docking algorithm, nicknamed SnapDock, is presented. It employs a Geometric Hashing-based structural alignment scheme to align the target proteins to the interfaces of non-redundant protein–protein interface libraries. Docking of a pair of proteins utilizing the 22 600 interface PIFACE library is performed in < 2 min on the average. A flexible version of the algorithm allowing hinge motion in one of the proteins is presented as well. Results: To evaluate the performance of the algorithm a blind re-modelling of 3547 PDB complexes, which have been uploaded after the PIFACE publication has been performed with success ratio of about 35%. Interestingly, a similar experiment with the template free PatchDock docking algorithm yielded a success rate of about 23% with roughly 1/3 of the solutions different from those of SnapDock. Consequently, the combination of the two methods gave a 42% success ratio. Availability and implementation: A web server of the application is under development. Contact: michaelestrin@gmail.com or wolfson@tau.ac.il PMID:28881968

Effects of Thiamethoxam-Treated Seed on Mexican Bean Beetle (Coleoptera: Coccinellidae), Nontarget Arthropods, and Crop Performance in Southwestern Virginia Snap Beans.

PubMed

Nottingham, L; Kuhar, T P; Kring, T; Herbert, D A; Arancibia, R; Schultz, P

2017-12-08

Thiamethoxam is a neonicotinoid insecticide commonly applied directly to the seeds (seed-treatment) of commercial snap beans, Phaseolus vulgaris L. While previous studies have examined target and nontarget effects of thiamethoxam seed-treatments in snap beans and other crops, to our knowledge, none have been conducted in agroecosystems predominated by the pest Mexican bean beetle, Epilachna varivestis Mulsant (Coleoptera: Coccinellidae). This study examined the effects of thiamethoxam-treated snap beans on E. varivestis, other arthropods, and crop performance in southwestern Virginia. Greenhouse experiments were conducted to evaluate residual toxicity of treated snap beans to E. varivestis and a key predator, Podisus maculiventris (Say) (Hemiptera: Pentatomidae). Treated plants were highly toxic to E. varivestis at 13 d, moderately toxic from 16 to 20 d, and minimally toxic at 24 d. P. maculiventris was unaffected by exposure to treated plants or by feeding on E. varivestis that consumed treated plants. Small plot field experiments in 2014 and 2015 showed no significant effects of thiamethoxam seed-treatments on E. varivestis densities, other arthropods, crop injury, or yield. In 2016, planting was delayed by persistent rain, resulting in early E. varivestis colonization. In this year, thiamethoxam-treated plants had significantly lower densities and feeding injury from E. varivestis, followed by significantly higher yields. Natural enemies were unaffected by seed-treatments in all field experiments. These experiments demonstrated that thiamethoxam seed-treatments provide control of E. varivestis when beetles infest fields within 2 to 3 wk after planting; but otherwise provide negligible advantages. Negative effects from thiamethoxam seed-treatments on nontarget arthropods appear minimal for snap beans in this region. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For permissions, please

Palisade endings in extraocular eye muscles revealed by SNAP-25 immunoreactivity.

PubMed

Eberhorn, Andreas C; Horn, Anja K E; Eberhorn, Nicola; Fischer, Petra; Boergen, Klaus-Peter; Büttner-Ennever, Jean A

2005-03-01

Palisade endings form a cuff of nerve terminals around the tip of muscle fibres. They are found only in extraocular muscles, but no definite evidence for their role in eye movements has been established. Palisade endings have been reported in all species so far investigated except the rat. In this study we demonstrate that antibodies against SNAP-25, the synaptosomal associated protein of 25 kDa, reliably visualize the complete motor, sensory and autonomic innervation of the extraocular muscles in human, monkey and rat. The SNAP-25 antibody can be combined with other immunofluorescence procedures, and is used here to study properties of palisade endings. With SNAP-25 immunolabelling putative palisade endings are identified in the rat for the first time. They are not well branched, but fulfil several criteria of palisade endings, being associated with non-twitch fibres as shown by double labelling with 'myosin heavy chain slow-twitch' antibodies. The putative palisade endings of the rat lack alpha-bungarotoxin binding, which implies that these synapses are sensory. If palisade endings are sensory then they could function as an eye muscle proprioceptor. They seem to be a general feature of all vertebrate eye muscles, unlike the other two extraocular proprioceptors, muscle spindles and Golgi tendon organs, the presence of which varies widely between species.

Spaceport news index, December 1962 - February 1972

NASA Technical Reports Server (NTRS)

1972-01-01

This index is intended to serve as a ready reference tool for the names, places and events that comprise the history of John F. Kennedy Space Center. The period covered is December 1962 through February 1972. The arrangement is alphabetical by subject; under each subject, entries are arranged alphabetically by title. To facilitate use, cross references and scope notes have been provided.

Multi-environment selection of small sieve snap beans reduces production constraints in East Africa and subtropical regions

USDA-ARS?s Scientific Manuscript database

Common bean rust caused by Uromyces appendiculatus, and heat stress lower the yield and quality of snap beans (Phaseolus vulgaris L.) in East Africa. Four snap bean breeding lines previously selected for broad-spectrum rust resistance (involving Ur-4 and Ur-11 rust genes) and heat tolerance followin...

SnapShot: Phosphoregulation of Mitosis.

PubMed

Burgess, Andrew; Vuong, Jenny; Rogers, Samuel; Malumbres, Marcos; O'Donoghue, Seán I

2017-06-15

During mitosis, a cell divides its duplicated genome into two identical daughter cells. This process must occur without errors to prevent proliferative diseases (e.g., cancer). A key mechanism controlling mitosis is the precise timing of more than 32,000 phosphorylation and dephosphorylation events by a network of kinases and counterbalancing phosphatases. The identity, magnitude, and temporal regulation of these events have emerged recently, largely from advances in mass spectrometry. Here, we show phosphoevents currently believed to be key regulators of mitosis. For an animated version of this SnapShot, please see http://www.cell.com/cell/enhanced/odonoghue2. Copyright © 2017. Published by Elsevier Inc.

EBT Payment for Online Grocery Orders: a Mixed-Methods Study to Understand Its Uptake among SNAP Recipients and the Barriers to and Motivators for Its Use.

PubMed

Martinez, Olivia; Tagliaferro, Barbara; Rodriguez, Noemi; Athens, Jessica; Abrams, Courtney; Elbel, Brian

2018-04-01

To examine Supplemental Nutrition Assistance Program (SNAP) recipients' use of the first online supermarket accepting Electronic Benefit Transfer (EBT) payment. In this mixed-methods study, the authors collected EBT purchase data from an online grocer and attempted a randomized controlled trial in the South Bronx, New York City, followed by focus groups with SNAP beneficiaries aged ≥18 years. Participants were randomized to shop at their usual grocery store or an online supermarket for 3 months. Focus groups explored barriers and motivators to online EBT redemption. Few participants made online purchases, even when incentivized in the randomized controlled trial. Qualitative findings highlighted a lack of perceived control over the online food selection process as a key barrier to purchasing food online. Motivators included fast, free shipping and discounts. Electronic Benefit Transfer for online grocery purchases has the potential to increase food access among SNAP beneficiaries, but challenges exist to this new food buying option. Understanding online food shopping barriers and motivators is critical to the success of policies targeting the online expansion of SNAP benefits. Copyright © 2017 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

A qualitative study of diverse experts' views about barriers and strategies to improve the diets and health of Supplemental Nutrition Assistance Program (SNAP) beneficiaries.

PubMed

Leung, Cindy W; Hoffnagle, Elena E; Lindsay, Ana C; Lofink, Hayley E; Hoffman, Vanessa A; Turrell, Sophie; Willett, Walter C; Blumenthal, Susan J

2013-01-01

The Supplemental Nutrition Assistance Program (SNAP), the largest federal food assistance program, currently serves 44.7 million Americans with a budget of $75 billion in 2011. This study engaged leading experts for in-depth, semi-structured interviews to explore their opinions concerning the existing challenges and barriers to eating nutritiously in SNAP. Experts also proposed strategies for improving nutritional status among SNAP recipients. Twenty-seven individuals were interviewed from advocacy, government, industry, and research organizations. Interviews were recorded, transcribed, coded, and analyzed for thematic content. The high cost of nutrient-rich foods, inadequate SNAP benefits, limited access to purchasing healthy foods, and environmental factors associated with poverty were identified as barriers that influence nutrition among low-income households in the United States. Six themes emerged among respondents from diverse sectors about how to address these challenges, including providing SNAP participants with incentives to purchase nutrient-rich food consistent with the 2010 Dietary Guidelines for Americans, restricting the purchase of nutrient-poor foods and beverages with program benefits, modifying the frequency of SNAP benefit distribution, enhancing nutrition education, improving the SNAP retailer environment, and increasing state and federal level coordination and consistency of program implementation. Given the recent dramatic increase in SNAP enrollment, policymakers must address existing barriers as well as consider new strategies to improve nutrition policies in SNAP so that the program can continue to address food insecurity needs as well as provide a healthful diet for SNAP beneficiaries. Copyright © 2013 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

A Qualitative Study of Diverse Experts’ Views About Barriers and Strategies to Improve the Diets and Health of Supplemental Nutrition Assistance Program (SNAP) Beneficiaries

PubMed Central

Leung, Cindy W.; Hoffnagle, Elena E.; Lindsay, Ana C.; Lofink, Hayley E.; Hoffman, Vanessa A.; Turrell, Sophie; Willett, Walter C.; Blumenthal, Susan J.

2012-01-01

The Supplemental Nutrition Assistance Program (SNAP), the largest federal food assistance program, currently serves 44.7 million Americans with a budget of $75 billion in 2011. This study engaged leading experts for in-depth, semi-structured interviews to explore their opinions concerning the existing challenges and barriers to eating nutritiously in SNAP. Experts also proposed strategies for improving nutritional status among SNAP recipients. Twenty-seven individuals were interviewed from advocacy, government, industry, and research organizations. Interviews were recorded, transcribed, coded and analyzed for thematic content. The high cost of nutrient-rich foods, inadequate SNAP benefits, limited access to purchasing healthy foods, and environmental factors associated with poverty were identified as barriers that influence nutrition among low-income households in the United States. Six themes emerged among respondents from diverse sectors about how to address these challenges including: 1) providing SNAP participants with incentives to purchase nutrient-rich food consistent with the 2010 Dietary Guidelines for Americans; 2) restricting the purchase of nutrient-poor foods and beverages with program benefits; 3) modifying the frequency of SNAP benefit distribution; 4) enhancing nutrition education; 5) improving the SNAP retailer environment and 6) increasing state and federal level coordination and consistency of program implementation. Given the recent dramatic increase in SNAP enrollment, policymakers must address existing barriers as well as consider new strategies to improve nutrition policies in SNAP so that the program can continue to address food insecurity needs as well as provide a healthful diet for SNAP beneficiaries. PMID:23260725

SnapShot: Fanconi anemia and associated proteins.

PubMed

Wang, Anderson T; Smogorzewska, Agata

2015-01-15

Fanconi anemia is a genetic disorder resulting from biallelic mutations in one of the 17 FANC genes. It is characterized by congenital abnormalities, bone marrow failure, and cancer predisposition. The underlying cause is genomic instability resulting from the deficiency in replication-dependent DNA interstrand crosslink repair pathway commonly referred to as the Fanconi anemia-BRCA pathway. This SnapShot presents the key factors involved. Copyright © 2015 Elsevier Inc. All rights reserved.

8. Historic American Buildings Survey Ronald Partridge, Photographer August 1962 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Historic American Buildings Survey Ronald Partridge, Photographer August 1962 DETAIL OF COLUMNS AND GIRDERS (220 'K' Street) - Big Four Building, 220-226 K Street, Sacramento, Sacramento County, CA

10. Historic American Buildings Survey Ronald Partridge, Photographer August 1962 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Historic American Buildings Survey Ronald Partridge, Photographer August 1962 COLUMN ORNAMENT AT 226 'K' Street (Stanford Building) - Big Four Building, 220-226 K Street, Sacramento, Sacramento County, CA

Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study.

PubMed

Burnham, Samantha C; Bourgeat, Pierrick; Doré, Vincent; Savage, Greg; Brown, Belinda; Laws, Simon; Maruff, Paul; Salvado, Olivier; Ames, David; Martins, Ralph N; Masters, Colin L; Rowe, Christopher C; Villemagne, Victor L

2016-09-01

Brain amyloid β (Aβ) deposition and neurodegeneration have been documented in about 50-60% of cognitively healthy elderly individuals (aged 60 years or older). The long-term cognitive consequences of the presence of Alzheimer's disease pathology and neurodegeneration, and whether they have an independent or synergistic effect on cognition, are unclear. We aimed to characterise the long-term clinical and cognitive trajectories of healthy elderly individuals using a two-marker (Alzheimer's disease pathology and neurodegeneration) imaging construct. Between Nov 3, 2006, and Nov 25, 2014, 573 cognitively healthy individuals in Melbourne and Perth, Australia, (mean age 73·1 years [SD 6·2]; 58% women) were enrolled in the Australian Imaging, Biomarker and Lifestyle (AIBL) study. Alzheimer's disease pathology (A) was determined by measuring Aβ deposition by PET, and neurodegeneration (N) was established by measuring hippocampal volume using MRI. Individuals were categorised as A(-)N(-), A(+)N(-), A(+)N(+), or suspected non-Alzheimer's disease pathophysiology (A(-)N(+), SNAP). Clinical progression, hippocampal volume, standard neuropsychological tests, and domain-specific and global cognitive composite scores were assessed over 6 years of follow-up. Linear mixed effect models and a Cox proportional hazards model of survival were used to evaluate, compare, and contrast the clinical, cognitive, and volumetric trajectories of patients in the four AN categories. 50 (9%) healthy individuals were classified as A(+)N(+), 87 (15%) as A(+)N(-), 310 (54%) as A(-)N(-), and 126 (22%) as SNAP. APOE ε4 was more frequent in participants in the A(+)N(+) (27; 54%) and A(+)N(-) (42; 48%) groups than in the A(-)N(-) (66; 21%) and SNAP groups (23; 18%). The A(+)N(-) and A(+)N(+) groups had significantly faster cognitive decline than the A(-)N(-) group (0·08 SD per year for AIBL-Preclinical AD Cognitive Composite [PACC]; p<0·0001; and 0·25; p<0·0001; respectively). The A (+)N

Reflective Polyethylene Mulch Reduces Mexican Bean Beetle (Coleoptera: Coccinellidae) Densities and Damage in Snap Beans.

PubMed

Nottingham, L B; Kuhar, T P

2016-08-01

Mexican bean beetle, Epilachna varivestis Mulsant, is a serious pest of snap beans, Phaseolus vulgaris L., in the eastern United States. These beetles are intolerant to direct sunlight, explaining why individuals are typically found on the undersides of leaves and in the lower portion of the plant canopy. We hypothesized that snap beans grown on reflective, agricultural polyethylene (plastic mulch) would have fewer Mexican bean beetles and less injury than those grown on black plastic or bare soil. In 2014 and 2015, beans were seeded into beds of metallized, white, and black plastic, and bare soil, in field plots near Blacksburg, VA. Mexican bean beetle density, feeding injury, predatory arthropods, and snap bean yield were sampled. Reflected light intensity, temperature, and humidity were monitored using data loggers. Pyranometer readings showed that reflected light intensity was highest over metallized plastic and second highest over white plastic; black plastic and bare soil were similarly low. Temperature and humidity were unaffected by treatments. Significant reductions in Mexican bean beetle densities and feeding injury were observed in both metallized and white plastic plots compared to black plastic and bare soil, with metallized plastic having the fewest Mexican bean beetle life stages and injury. Predatory arthropod densities were not reduced by reflective plastic. Metallized plots produced the highest yields, followed by white. The results of this study suggest that growing snap beans on reflective plastic mulch can suppress the incidence and damage of Mexican bean beetle, and increase yield in snap beans. © The Authors 2016. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

A fluorogenic probe for SNAP-tagged plasma membrane proteins based on the solvatochromic molecule Nile Red.

PubMed

Prifti, Efthymia; Reymond, Luc; Umebayashi, Miwa; Hovius, Ruud; Riezman, Howard; Johnsson, Kai

2014-03-21

A fluorogenic probe for plasma membrane proteins based on the dye Nile Red and SNAP-tag is introduced. It takes advantage of Nile Red, a solvatochromic molecule highly fluorescent in an apolar environment, such as cellular membranes, but almost dark in a polar aqueous environment. The probe possesses a tuned affinity for membranes allowing its Nile Red moiety to insert into the lipid bilayer of the plasma membrane, becoming fluorescent, only after its conjugation to a SNAP-tagged plasma membrane protein. The fluorogenic character of the probe was demonstrated for different SNAP-tag fusion proteins, including the human insulin receptor. This work introduces a new approach for generating a powerful turn-on probe for "no-wash" labeling of plasma membrane proteins with numerous applications in bioimaging.

Starfleet Deferred: Project Orion in the 1962 Air Force Space Program

NASA Astrophysics Data System (ADS)

Ziarnick, B.

Project Orion, the Cold War American program (1957-1965) studying nuclear pulse propulsion for space applications, has long interested space enthusiasts for what it was and what it might have been, but it has long been believed that neither the United States government nor the US Air Force took the program very seriously. However, recently declassified US Air Force documents shed more light on the classified history of Project Orion. Far from being ignored by Air Force leadership, through the efforts of the Strategic Air Command, Air Force leaders like General Curtis LeMay were convinced that Project Orion should be funded as a major weapons system. The high water mark of Project Orion was the 1962 Air Force Space Program proposal by the Air Force Chief of Staff to devote almost twenty percent of the Air Force space budget from 1962-1967 to Orion development before the program was cancelled by the civilian Secretary of the Air Force under pressure from the Department of Defense. This paper details the history of Project Orion in the 1962 Air Force Space Program proposal, and concludes with a few lessons learned for use by modern interstellar advocates.

Efficacy and enlightenment: LSD psychotherapy and the Drug Amendments of 1962.

PubMed

Oram, Matthew

2014-04-01

The decline in therapeutic research with lysergic acid diethylamide (LSD) in the United States over the course of the 1960s has commonly been attributed to the growing controversy surrounding its recreational use. However, research difficulties played an equal role in LSD psychotherapy's demise, as they frustrated researchers' efforts to clearly establish the efficacy of treatment. Once the Kefauver Harris Drug Amendments of 1962 introduced the requirement that proof of efficacy be established through controlled clinical trials before a drug could be approved to market, the value of clinical research became increasingly dependent on the scientific rigor of the trial's design. LSD psychotherapy's complex method of utilizing drug effects to catalyze a psychological treatment clashed with the controlled trial methodology on both theoretical and practical levels, making proof of efficacy difficult to obtain. Through a close examination of clinical trials performed after 1962, this article explores how the new emphasis on controlled clinical trials frustrated the progress of LSD psychotherapy research by focusing researchers' attention on trial design to the detriment of their therapeutic method. This analysis provides a new perspective on the death of LSD psychotherapy and explores the implications of the Drug Amendments of 1962.

Palisade endings in extraocular eye muscles revealed by SNAP-25 immunoreactivity

PubMed Central

Eberhorn, Andreas C; Horn, Anja KE; Eberhorn, Nicola; Fischer, Petra; Boergen, Klaus-Peter; Büttner-Ennever, Jean A

2005-01-01

Palisade endings form a cuff of nerve terminals around the tip of muscle fibres. They are found only in extraocular muscles, but no definite evidence for their role in eye movements has been established. Palisade endings have been reported in all species so far investigated except the rat. In this study we demonstrate that antibodies against SNAP-25, the synaptosomal associated protein of 25 kDa, reliably visualize the complete motor, sensory and autonomic innervation of the extraocular muscles in human, monkey and rat. The SNAP-25 antibody can be combined with other immunofluorescence procedures, and is used here to study properties of palisade endings. With SNAP-25 immunolabelling putative palisade endings are identified in the rat for the first time. They are not well branched, but fulfil several criteria of palisade endings, being associated with non-twitch fibres as shown by double labelling with ‘myosin heavy chain slow-twitch’ antibodies. The putative palisade endings of the rat lack α-bungarotoxin binding, which implies that these synapses are sensory. If palisade endings are sensory then they could function as an eye muscle proprioceptor. They seem to be a general feature of all vertebrate eye muscles, unlike the other two extraocular proprioceptors, muscle spindles and Golgi tendon organs, the presence of which varies widely between species. PMID:15733303

A BETTER LIFE FOR FARM FAMILIES, NATIONAL SHARECROPPERS FOUNDATION, SOUTHERN RURAL CONFERENCE, BRICKS, NOVEMBER 14-16, 1962.

ERIC Educational Resources Information Center

GRAHAM, FRANK P.; AND OTHERS

RURAL POVERTY WAS DEEPENED RATHER THAN AMELIORATED BY A REVOLUTION IN SOUTHERN AGRICULTURE. THERE WERE 3.4 MILLION SOUTHERN FARMERS IN 1935, THIS NUMBER DECREASED TO LESS THAN 1.6 MILLION IN 1962. AVERAGE YEARLY EARNINGS WERE LESS THAN $2,500. THE RURAL AREAS DEVELOPMENT PROGRAM HAS TRIED TO ATTRACT INDUSTRY TO COUNTY OR MULTI-COUNTY AREAS IN…

SnapAnatomy, a computer-based interactive tool for independent learning of human anatomy.

PubMed

Yip, George W; Rajendran, Kanagasuntheram

2008-06-01

Computer-aided instruction materials are becoming increasing popular in medical education and particularly in the teaching of human anatomy. This paper describes SnapAnatomy, a new interactive program that the authors designed for independent learning of anatomy. SnapAnatomy is primarily tailored for the beginner student to encourage the learning of anatomy by developing a three-dimensional visualization of human structure that is essential to applications in clinical practice and the understanding of function. The program allows the student to take apart and to accurately put together body components in an interactive, self-paced and variable manner to achieve the learning outcome.

SnapShot: Hormones of the gastrointestinal tract.

PubMed

Coate, Katie C; Kliewer, Steven A; Mangelsdorf, David J

2014-12-04

Specialized endocrine cells secrete a variety of peptide hormones all along the gastrointestinal (GI) tract, making it one of the largest endocrine organs in the body. Nutrients and developmental and neural cues trigger the secretion of gastrointestinal (GI) hormones from specialized endocrine cells along the GI tract. These hormones act in target tissues to facilitate digestion and regulate energy homeostasis. This SnapShot summarizes the production and functions of GI hormones. Copyright © 2014 Elsevier Inc. All rights reserved.

Implementation of Wireless Terminals at Farmers’ Markets: Impact on SNAP Redemption and Overall Sales

PubMed Central

Bertmann, Farryl M. W.; Ohri-Vachaspati, Punam; Buman, Matthew P.

2012-01-01

Although farmers’ markets offer healthy foods for purchase, many lack the equipment necessary to process convenient, card-based transactions. We assessed the impact of providing wireless terminals to 5 markets on overall sales and redemption of Supplemental Nutrition Assistance Program (SNAP) benefits. Sales increased significantly at 4 of the 5 markets after implementation of the terminals, and overall sales increased above and beyond SNAP redemption alone. Implementation of wireless terminals may be important for improving the financial stability and accessibility of farmers’ markets. PMID:22594725

SNAP dendrimers: multivalent protein display on dendrimer-like DNA for directed evolution.

PubMed

Kaltenbach, Miriam; Stein, Viktor; Hollfelder, Florian

2011-09-19

Display systems connect a protein with the DNA encoding it. Such systems (e.g., phage or ribosome display) have found widespread application in the directed evolution of protein binders and constitute a key element of the biotechnological toolkit. In this proof-of-concept study we describe the construction of a system that allows the display of multiple copies of a protein of interest in order to take advantage of avidity effects during affinity panning. To this end, dendrimer-like DNA is used as a scaffold with docking points that can join the coding DNA with multiple protein copies. Each DNA construct is compartmentalised in water-in-oil emulsion droplets. The corresponding protein is expressed, in vitro, inside the droplets as a SNAP-tag fusion. The covalent bond between DNA and the SNAP-tag is created by reaction with dendrimer-bound benzylguanine (BG). The ability to form dendrimer-like DNA straightforwardly from oligonucleotides bearing BG allowed the comparison of a series of templates differing in size, valency and position of BG. In model selections the most efficient constructs show recoveries of up to 0.86 % and up to 400-fold enrichments. The comparison of mono- and multivalent constructs suggests that the avidity effect enhances enrichment by up to fivefold and recovery by up to 25-fold. Our data establish a multivalent format for SNAP-display based on dendrimer-like DNA as the first in vitro display system with defined tailor-made valencies and explore a new application for DNA nanostructures. These data suggest that multivalent SNAP dendrimers have the potential to facilitate the selection of protein binders especially during early rounds of directed evolution, allowing a larger diversity of candidate binders to be recovered. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

40 CFR 82.180 - Agency review of SNAP submissions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... until EPA has received data it judges adequate to support analysis of the submission. (4) Letter of... time the Agency perceives a lack of information necessary to reach a SNAP determination, it will... expires even if the Agency fails to reach a decision within the 90-day review period or fails to...

Overweight and Obesity, Weight Perception, and Weight Management Practices Among Supplemental Nutrition Assistance Program-Education (SNAP-Ed) Participants in Georgia: A Needs Assessment.

PubMed

Bailey, Claudette; Lee, Jung Sun

2017-05-01

Examine associations among weight status, weight perception, and weight management practices of Supplemental Nutrition Assistance Program-Education (SNAP-Ed) participants in Georgia. Self-reported weight, height, and weight-related practices were assessed and analyzed in 270 SNAP-Ed participants. Almost three quarters of the sample self-reported overweight or obesity. Among overweight and obese subjects, 39% and 69%, respectively, accurately perceived themselves as overweight. More than half of the sample desired weight loss and 44% had attempted weight loss in the past year. Overweight/obese subjects who accurately perceived their weight were more likely to desire and to have attempted weight loss than those who under-perceived their weight. Approximately 58% of all subjects who had attempted to lose weight reported use of both methods suggested for weight loss: exercise and dietary changes. The high prevalence of self-reported overweight/obesity combined with a desire to lose weight among the study sample demonstrated the necessity to develop SNAP-Ed curricula emphasizing weight management. Copyright © 2017 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

Different mechanics of snap-trapping in the two closely related carnivorous plants Dionaea muscipula and Aldrovanda vesiculosa

NASA Astrophysics Data System (ADS)

Poppinga, Simon; Joyeux, Marc

2011-10-01

The carnivorous aquatic waterwheel plant (Aldrovanda vesiculosa L.) and the closely related terrestrial venus flytrap (Dionaea muscipula Sol. ex J. Ellis) both feature elaborate snap-traps, which shut after reception of an external mechanical stimulus by prey animals. Traditionally, Aldrovanda is considered as a miniature, aquatic Dionaea, an assumption which was already established by Charles Darwin. However, videos of snapping traps from both species suggest completely different closure mechanisms. Indeed, the well-described snapping mechanism in Dionaea comprises abrupt curvature inversion of the two trap lobes, while the closing movement in Aldrovanda involves deformation of the trap midrib but not of the lobes, which do not change curvature. In this paper, we present detailed mechanical models for these plants, which are based on the theory of thin solid membranes and explain this difference by showing that the fast snapping of Aldrovanda is due to kinematic amplification of the bending deformation of the midrib, while that of Dionaea unambiguously relies on the buckling instability that affects the two lobes.

Testing Two Alternative Pathological Personality Measures in the Assessment of Psychopathy: An Examination of the Snap and DAPP-BQ.

PubMed

Pryor, Lauren R; Miller, Joshua D; Gaughan, Eric T

2009-02-01

The current study examined the interrelations between two measures of pathological personality, the Schedule for Nonadaptive and Adaptive Personality (SNAP; Clark, 1993) and the Dimensional Assessment of Personality Pathology-Basic Questionnaire (DAPP-BQ; Livesley, 1990), and their respective relations with psychopathy. Two hundred and twenty-nine undergraduate students completed the SNAP, DAPP-BQ, and two self-report psychopathy inventories, the Levenson Self-Report Psychopathy Scale (LSRP; Levenson, Kiehl, & Fitzpatrick, 1995) and the Psychopathic Personality Inventory-Revised (PPI-R; Lilienfeld & Widows, 2005). Results revealed good convergence between conceptually related SNAP and DAPP-BQ subscales. Both the SNAP and DAPP-BQ accounted for a substantial amount of variance in psychopathy scores although the DAPP-BQ accounted for a larger percentage of the variance and demonstrated greater incremental validity. Results suggest that both measures can be successfully used to assess traits associated with psychopathy.

Septin 7 reduces nonmuscle myosin IIA activity in the SNAP23 complex and hinders GLUT4 storage vesicle docking and fusion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wasik, Anita A.; Dumont, Vincent; Tienari, Jukka

Glomerular epithelial cells, podocytes, are insulin responsive and can develop insulin resistance. Here, we demonstrate that the small GTPase septin 7 forms a complex with nonmuscle myosin heavy chain IIA (NMHC-IIA; encoded by MYH9), a component of the nonmuscle myosin IIA (NM-IIA) hexameric complex. We observed that knockdown of NMHC-IIA decreases insulin-stimulated glucose uptake into podocytes. Both septin 7 and NM-IIA associate with SNAP23, a SNARE protein involved in GLUT4 storage vesicle (GSV) docking and fusion with the plasma membrane. We observed that insulin decreases the level of septin 7 and increases the activity of NM-IIA in the SNAP23 complex,more » as visualized by increased phosphorylation of myosin regulatory light chain. Also knockdown of septin 7 increases the activity of NM-IIA in the complex. The activity of NM-IIA is increased in diabetic rat glomeruli and cultured human podocytes exposed to macroalbuminuric sera from patients with type 1 diabetes. Collectively, the data suggest that the activity of NM-IIA in the SNAP23 complex plays a key role in insulin-stimulated glucose uptake into podocytes. Furthermore, we observed that septin 7 reduces the activity of NM-IIA in the SNAP23 complex and thereby hinders GSV docking and fusion with the plasma membrane. - Highlights: • Septin 7, nonmuscle myosin heavy chain IIA (NMHC-IIA) and SNAP23 form a complex. • Knockdown of septin 7 increases NM-IIA activity in the SNAP23 complex. • Insulin decreases septin 7 level and increases NM-IIA activity in the SNAP23 complex. • Septin 7 hinders GSV docking/fusion by reducing NM-IIA activity in the SNAP23 complex.« less

Morphological study on the olfactory systems of the snapping turtle, Chelydra serpentina.

PubMed

Nakamuta, Nobuaki; Nakamuta, Shoko; Kato, Hideaki; Yamamoto, Yoshio

2016-06-01

In this study, the olfactory system of a semi-aquatic turtle, the snapping turtle, has been morphologically investigated by electron microscopy, immunohistochemistry, and lectin histochemistry. The nasal cavity of snapping turtle was divided into the upper and lower chambers, lined by the sensory epithelium containing ciliated and non-ciliated olfactory receptor neurons, respectively. Each neuron expressed both Gαolf, the α-subunit of G-proteins coupling to the odorant receptors, and Gαo, the α-subunit of G-proteins coupling to the type 2 vomeronasal receptors. The axons originating from the upper chamber epithelium projected to the ventral part of the olfactory bulb, while those from the lower chamber epithelium to the dorsal part of the olfactory bulb. Despite the identical expression of G-protein α-subunits in the olfactory receptor neurons, these two projections were clearly distinguished from each other by the differential expression of glycoconjugates. In conclusion, these data indicate the presence of two types of olfactory systems in the snapping turtle. Topographic arrangement of the upper and lower chambers and lack of the associated glands in the lower chamber epithelium suggest their possible involvement in the detection of odorants: upper chamber epithelium in the air and the lower chamber epithelium in the water. Copyright © 2016 Elsevier Ltd. All rights reserved.

SNAP: A computer program for generating symbolic network functions

NASA Technical Reports Server (NTRS)

Lin, P. M.; Alderson, G. E.

1970-01-01

The computer program SNAP (symbolic network analysis program) generates symbolic network functions for networks containing R, L, and C type elements and all four types of controlled sources. The program is efficient with respect to program storage and execution time. A discussion of the basic algorithms is presented, together with user's and programmer's guides.

SNAP-8 refractory boiler development program

NASA Technical Reports Server (NTRS)

Fuller, R. A.

1974-01-01

Performance and endurance tests of the SNAP-8, SN-1 refractory metal boiler are described. The tests were successful and indicated that the boiler heat transfer area could be reduced significantly primarily because of the wetting characteristics of mercury on tantalum in a contaminant-free environment. A continuous endurance test of more than 10,000 hours was conducted without noticeable change in the thermal performance of the boiler. A conclusion of the metallographic examination of the boiler following the endurance test was that expected boiler life would be of the order of 40,000 hours at observed corrosion rates.

SNAP/SHOT Your Ability to Support That Next Application.

ERIC Educational Resources Information Center

Jones, Ernest L.

SNAP/SHOT (System Network Analysis Program-Simulated Host Overview Technique) is a discrete simulation of a network and/or host model available through IBM at the Raleigh System Center. The simulator provides an analysis of a total IBM Communications System. Input data must be obtained from RMF, SMF, and the CICS Analyzer to determine the existing…

Surface water records of Indiana, 1962

USGS Publications Warehouse

,

1962-01-01

The surface-water records for the 1962 water year for gaging stations, partial-record stations, and miscellaneous sites within the State of Indiana are given in this report. For convenience there are also included records for a few pertinent gaging stations in bordering States. The records were collected and computed by the Water Resources Division of the U.S. Geological Survey, under the direction of Malcolm D. Hale, district engineer, Surface Water Branch. This report marks the beginning of a new method of presenting, annually, basic data on surface-water records by States. Through September 30, 1960, the records of discharge and stage of streams and contents and stage of lakes or reservoirs were published in an annual series of U.S. Geological Survey water-supply papers entitled "Surface Water Supply of the United States." Since 1951 there have been 20 volumes in the series; each volume covered an area whose boundaries coincided with those of certain natural drainage areas. The records in Indiana were contained in Parts 3A, 4 and 5 of that series. Beginning with the 1961 water year, streamflow records and related data will be released by the Geological Survey in annual reports on a State-boundary basis. Distribution of these basic-data reports will be limited and primarily for local needs. The records later will be published in Geological Survey water-supply papers at 5-year intervals. These 5-year water-supply papers will show daily discharge and will be compiled on the same geographical areas previously used for the annual series; however, some of the 14 parts of coterminous United States will be further subdivided.

An essential and NSF independent role for α-SNAP in store-operated calcium entry.

PubMed

Miao, Yong; Miner, Cathrine; Zhang, Lei; Hanson, Phyllis I; Dani, Adish; Vig, Monika

2013-07-16

Store-operated calcium entry (SOCE) by calcium release activated calcium (CRAC) channels constitutes a primary route of calcium entry in most cells. Orai1 forms the pore subunit of CRAC channels and Stim1 is the endoplasmic reticulum (ER) resident Ca(2+) sensor. Upon store-depletion, Stim1 translocates to domains of ER adjacent to the plasma membrane where it interacts with and clusters Orai1 hexamers to form the CRAC channel complex. Molecular steps enabling activation of SOCE via CRAC channel clusters remain incompletely defined. Here we identify an essential role of α-SNAP in mediating functional coupling of Stim1 and Orai1 molecules to activate SOCE. This role for α-SNAP is direct and independent of its known activity in NSF dependent SNARE complex disassembly. Importantly, Stim1-Orai1 clustering still occurs in the absence of α-SNAP but its inability to support SOCE reveals that a previously unsuspected molecular re-arrangement within CRAC channel clusters is necessary for SOCE. DOI:http://dx.doi.org/10.7554/eLife.00802.001.

Polycyclic aromatic hydrocarbons affect survival and development of common snapping turtle (Chelydra serpentina) embryos and hatchlings.

PubMed

Van Meter, Robin J; Spotila, James R; Avery, Harold W

2006-08-01

Polycyclic aromatic hydrocarbons (PAHs) are toxic compounds found in the John Heinz National Wildlife Refuge in Philadelphia, Pennsylvania. We assessed the impact of PAHs and crude oil on snapping turtle development and behavior by exposing snapping turtle eggs from the Refuge and from three clean reference sites to individual PAHs or a crude oil mixture at stage 9 of embryonic development. Exposure to PAHs had a significant effect on survival rates in embryos from one clean reference site, but not in embryos from the other sites. There was a positive linear relationship between level of exposure to PAHs and severity of deformities in embryos collected from two of the clean reference sites. Neither righting response nor upper temperature tolerance (critical thermal maximum, CTM) of snapping turtle hatchlings with no or minor deformities was significantly affected by exposure to PAHs.

SnapShot: Visualization to Propel Ice Hockey Analytics.

PubMed

Pileggi, H; Stolper, C D; Boyle, J M; Stasko, J T

2012-12-01

Sports analysts live in a world of dynamic games flattened into tables of numbers, divorced from the rinks, pitches, and courts where they were generated. Currently, these professional analysts use R, Stata, SAS, and other statistical software packages for uncovering insights from game data. Quantitative sports consultants seek a competitive advantage both for their clients and for themselves as analytics becomes increasingly valued by teams, clubs, and squads. In order for the information visualization community to support the members of this blossoming industry, it must recognize where and how visualization can enhance the existing analytical workflow. In this paper, we identify three primary stages of today's sports analyst's routine where visualization can be beneficially integrated: 1) exploring a dataspace; 2) sharing hypotheses with internal colleagues; and 3) communicating findings to stakeholders.Working closely with professional ice hockey analysts, we designed and built SnapShot, a system to integrate visualization into the hockey intelligence gathering process. SnapShot employs a variety of information visualization techniques to display shot data, yet given the importance of a specific hockey statistic, shot length, we introduce a technique, the radial heat map. Through a user study, we received encouraging feedback from several professional analysts, both independent consultants and professional team personnel.

Synaptosomal-associated protein 25 (Snap-25) gene polymorphism frequency in fibromyalgia syndrome and relationship with clinical symptoms.

PubMed

Balkarli, Ayse; Sengül, Cem; Tepeli, Emre; Balkarli, Huseyin; Cobankara, Veli

2014-05-31

SNAP-25 protein is contributory to plasma membrane and synaptic vesicle fusions that are critical points in neurotransmission. SNAP-25 gene is associated with behavioral symptoms, personality and psychological disorders. In addition, SNAP-25 protein can be related to different neurotransmitter functions due to its association with vesicle membrane transition and fusion. This is important because neurologic, cognitive, and psychologic disorders in fibromyalgia syndrome (FMS) can be related to this function. This relationship may be enlightening for etiopathogenesis of FMS and treatment approaches. We aimed to study a SNAP-25 gene polymorphism, which is related to many psychiatric diseases, and FMS association in this prospective study. We included 71 patients who were diagnosed according to new criteria and 57 matched healthy women in this study. Both groups were evaluated regarding age, height, weight, BMI, education level, marital and occupational status. A new diagnosis of FMS was made from criteria scoring, SF-36, Beck depression scale, and VAS that were applied to the patient group. SNAP-25 gene polymorphism and disease activity score correlations were compared. Mean age was 38±5,196 and 38.12±4.939 in patient and control groups, respectively (p=0.542). No significant difference was found between groups regarding age, height, weight, BMI, education level, marital or occupational status (p > 0.05). Ddel T/C genotype was significantly higher in the patient group (p = 0.009). MnlI gene polymorphism did not show a correlation with any score whereas a significant correlation was found between Ddel T/C genotype and Beck depression scale and VAS score (p < 0.05). FMS etiopathogenesis is not clearly known. Numerous neurologic, cognitive and psychological disorders were found during studies looking at cause. Our study showed increased SNAP-25 Ddel T/C genotype in FMS patients compared to the control group, which is related to behavioral symptoms, personality and

Dynamic Snap-Through of Thin-Walled Structures by a Reduced Order Method

NASA Technical Reports Server (NTRS)

Przekop, Adam; Rizzi, Stephen A.

2006-01-01

The goal of this investigation is to further develop nonlinear modal numerical simulation methods for application to geometrically nonlinear response of structures exposed to combined high intensity random pressure fluctuations and thermal loadings. The study is conducted on a flat aluminum beam, which permits a comparison of results obtained by a reduced-order analysis with those obtained from a numerically intensive simulation in physical degrees-of-freedom. A uniformly distributed thermal loading is first applied to investigate the dynamic instability associated with thermal buckling. A uniformly distributed random loading is added to investigate the combined thermal-acoustic response. In the latter case, three types of response characteristics are considered, namely: (i) small amplitude vibration around one of the two stable buckling equilibrium positions, (ii) intermittent snap-through response between the two equilibrium positions, and (iii) persistent snap-through response between the two equilibrium positions. For the reduced order analysis, four categories of modal basis functions are identified including those having symmetric transverse (ST), anti-symmetric transverse (AT), symmetric in-plane (SI), and anti-symmetric in-plane (AI) displacements. The effect of basis selection on the quality of results is investigated for the dynamic thermal buckling and combined thermal-acoustic response. It is found that despite symmetric geometry, loading, and boundary conditions, the AT and SI modes must be included in the basis as they participate in the snap-through behavior.

Dynamic Snap-Through of Thermally Buckled Structures by a Reduced Order Method

NASA Technical Reports Server (NTRS)

Przekop, Adam; Rizzi, Stephen A.

2007-01-01

The goal of this investigation is to further develop nonlinear modal numerical simulation methods for application to geometrically nonlinear response of structures exposed to combined high intensity random pressure fluctuations and thermal loadings. The study is conducted on a flat aluminum beam, which permits a comparison of results obtained by a reduced-order analysis with those obtained from a numerically intensive simulation in physical degrees-of-freedom. A uniformly distributed thermal loading is first applied to investigate the dynamic instability associated with thermal buckling. A uniformly distributed random loading is added to investigate the combined thermal-acoustic response. In the latter case, three types of response characteristics are considered, namely: (i) small amplitude vibration around one of the two stable buckling equilibrium positions, (ii) intermittent snap-through response between the two equilibrium positions, and (iii) persistent snap-through response between the two equilibrium positions. For the reduced-order analysis, four categories of modal basis functions are identified including those having symmetric transverse, anti-symmetric transverse, symmetric in-plane, and anti-symmetric in-plane displacements. The effect of basis selection on the quality of results is investigated for the dynamic thermal buckling and combined thermal-acoustic response. It is found that despite symmetric geometry, loading, and boundary conditions, the anti-symmetric transverse and symmetric in-plane modes must be included in the basis as they participate in the snap-through behavior.

Reduction of Thrombosis and Bacterial Infection via Controlled Nitric Oxide (NO) Release from S-Nitroso-N-acetylpenicillamine (SNAP) Impregnated CarboSil Intravascular Catheters

PubMed Central

2017-01-01

Nitric oxide (NO) has many important physiological functions, including its ability to inhibit platelet activation and serve as potent antimicrobial agent. The multiple roles of NO in vivo have led to great interest in the development of biomaterials that can deliver NO for specific biomedical applications. Herein, we report a simple solvent impregnation technique to incorporate a nontoxic NO donor, S-nitroso-N-acetylpenicillamine (SNAP), into a more biocompatible biomedical grade polymer, CarboSil 20 80A. The resulting polymer-crystal composite material yields a very stable, long-term NO release biomaterial. The SNAP impregnation process is carefully characterized and optimized, and it is shown that SNAP crystal formation occurs in the bulk of the polymer after solvent evaporation. LC-MS results demonstrate that more than 70% of NO release from this new composite material originates from the SNAP embedded CarboSil phase, and not from the SNAP species leaching out into the soaking solution. Catheters prepared with CarboSil and then impregnated with 15 wt % SNAP provide a controlled NO release over a 14 d period at physiologically relevant fluxes and are shown to significantly reduce long-term (14 day) bacterial biofilm formation against Staphylococcus epidermidis and Pseudonomas aeruginosa in a CDC bioreactor model. After 7 h of catheter implantation in the jugular veins of rabbit, the SNAP CarboSil catheters exhibit a 96% reduction in thrombus area (0.03 ± 0.01 cm2/catheter) compared to the controls (0.84 ± 0.19 cm2/catheter) (n = 3). These results suggest that SNAP impregnated CarboSil can become an attractive new biomaterial for use in preparing intravascular catheters and other implanted medical devices. PMID:28317023

Specifically and wash-free labeling of SNAP-tag fused proteins with a hybrid sensor to monitor local micro-viscosity.

PubMed

Wang, Chao; Song, Xinbo; Chen, Lingcheng; Xiao, Yi

2017-05-15

Viscosity, as one of the major factors of intracellular microenvironment, influences the function of proteins. To detect local micro-viscosity of a protein, it is a precondition to apply a viscosity sensor for specifically target to proteins. However, all the reported small-molecule probes are just suitable for sensing/imaging of macro-viscosity in biological fluids of entire cells or organelles. To this end, we developed a hybrid sensor BDP-V BG by connecting a viscosity-sensitive boron-dipyrromethene (BODIPY) molecular rotor (BDP-V) to O 6 -benzylguanine (BG) for specific detection of local micro-viscosity of SNAP-tag fused proteins. We measured and calculated the reaction efficiency between the sensor and SNAP-tag protein in vitro to confirm the high labeling specificity. We also found that the labeling reaction results in a 53-fold fluorescence enhancement for the rotor, which qualifies it as a wash-free sensor with ignorable background fluorescence. The high sensitivity of protein labeled sensor (BDP-V-SNAP) to the changes of local viscosity was evaluated by detecting the enhancement of fluorescence lifetimes. Further, with the sensor BDP-V BG, we achieved high specific labeling of cells expressing two SNAP-tag fused proteins (nuclear histone H2B and mitochondrial COX8A). Two-photon excited fluorescence lifetime imaging revealed that, the micro-viscosities nearby the SNAP-tag fused two proteins are distinct. The different changes of local micro-viscosity of SNAP-tag fused histone protein in apoptosis induced by three nucleus-targeted drugs were also characterized for the first time. Copyright © 2016 Elsevier B.V. All rights reserved.

Bubble snap-off and capillary-back pressure during counter-current spontaneous imbibition into model pores.

PubMed

Unsal, Evren; Mason, Geoffrey; Morrow, Norman R; Ruth, Douglas W

2009-04-09

A previous paper (Unsal, E.; Mason, G.; Ruth, D. W.; Morrow, N. R. J. Colloid Interface Sci. 2007, 315, 200-209) reported experiments involving counter-current spontaneous imbibition into a model pore system consisting of a rod in an angled slot covered by a glass plate. Such an arrangement gives two tubes with different cross-sections (both size and shape) with an interconnection through the gap between the rod and the plate. In the previous experiments, the wetting phase advanced in the small tube and nonwetting phase retreated in the large tube. No bubbles were formed. In this paper, we study experimentally and theoretically the formation of bubbles at the open end of the large tube and their subsequent snap-off. Such bubbles reduce the capillary back pressure produced by the larger tube and can thus have an effect on the local rate of imbibition. In the model pore system, the rod was either in contact with the glass, forming two independent tubes, or the rod was spaced from the glass to allow cross-flow between the tubes. For small gaps, there were three distinct menisci. The one with the highest curvature was between the rod and the plate. The next most highly curved was in the smaller tube, and the least highly curved meniscus was in the large tube and this was the tube from which the bubbles developed. The pressure in the dead end of the system was recorded during imbibition. Once the bubble starts to form outside of the tube, the pressure drops rapidly and then steadies. After the bubble snaps off, the pressure rises to almost the initial value and stays essentially constant until the next bubble starts to form. After snap-off, the meniscus in the large tube appears to invade the large tube for some distance. The snap-off is the result of capillary instability; it takes place significantly inside the large tube with flow of wetting phase moving in the angular corners. As imbibition into the small tube progresses, the rate of imbibition decreases and the

A SNAP-Tagged Derivative of HIV-1—A Versatile Tool to Study Virus-Cell Interactions

PubMed Central

Eckhardt, Manon; Anders, Maria; Muranyi, Walter; Heilemann, Mike; Krijnse-Locker, Jacomine; Müller, Barbara

2011-01-01

Fluorescently labeled human immunodeficiency virus (HIV) derivatives, combined with the use of advanced fluorescence microscopy techniques, allow the direct visualization of dynamic events and individual steps in the viral life cycle. HIV proteins tagged with fluorescent proteins (FPs) have been successfully used for live-cell imaging analyses of HIV-cell interactions. However, FPs display limitations with respect to their physicochemical properties, and their maturation kinetics. Furthermore, several independent FP-tagged constructs have to be cloned and characterized in order to obtain spectral variations suitable for multi-color imaging setups. In contrast, the so-called SNAP-tag represents a genetically encoded non-fluorescent tag which mediates specific covalent coupling to fluorescent substrate molecules in a self-labeling reaction. Fusion of the SNAP-tag to the protein of interest allows specific labeling of the fusion protein with a variety of synthetic dyes, thereby offering enhanced flexibility for fluorescence imaging approaches. Here we describe the construction and characterization of the HIV derivative HIVSNAP, which carries the SNAP-tag as an additional domain within the viral structural polyprotein Gag. Introduction of the tag close to the C-terminus of the matrix domain of Gag did not interfere with particle assembly, release or proteolytic virus maturation. The modified virions were infectious and could be propagated in tissue culture, albeit with reduced replication capacity. Insertion of the SNAP domain within Gag allowed specific staining of the viral polyprotein in the context of virus producing cells using a SNAP reactive dye as well as the visualization of individual virions and viral budding sites by stochastic optical reconstruction microscopy. Thus, HIVSNAP represents a versatile tool which expands the possibilities for the analysis of HIV-cell interactions using live cell imaging and sub-diffraction fluorescence microscopy. PMID:21799764

Internal Snapping Hip Syndrome: Incidence of Multiple-Tendon Existence and Outcome After Endoscopic Transcapsular Release.

PubMed

Ilizaliturri, Victor M; Suarez-Ahedo, Carlos; Acuña, Marco

2015-10-01

To report the frequency of presentation of bifid or multiple iliopsoas tendons in patients who underwent endoscopic release for internal snapping hip syndrome (ISHS) and to compare both groups. A consecutive series of patients with ISHS were treated with endoscopic transcapsular release of the iliopsoas tendon at the central compartment and prospectively followed up. The inclusion criteria were patients with a diagnosis of ISHS with failure of conservative treatment. During the procedure, the presence of a bifid tendon was intentionally looked for. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were evaluated preoperatively and at last follow-up. Four patients presented with a bifid tendon and one patient had 3 tendons. At a minimum of 12 months' follow-up, the presence of snapping recurrence was evaluated and the WOMAC scores were compared between both groups. Among 279 hip arthroscopies, 28 patients underwent central transcapsular iliopsoas tendon release. The mean age was 29.25 years (range, 16 to 65 years; 6 left and 22 right hips). Group 1 included 5 patients with multiple tendons; the remaining patients formed group 2 (n = 23). None of the patients presented with ISHS recurrence. The mean WOMAC score in group 1 was 39 points (95% confidence interval [CI], 26.2 to 55.4 points) preoperatively and 73.6 points (95% CI, 68.4 to 79.6 points) at last follow-up. In group 2 the mean WOMAC score was 47.21 points (95% CI, 44.4 to 58.2 points) preoperatively and 77.91 points (95% CI, 67.8 to 83.4 points) at last follow-up. We identified a bifid tendon retrospectively on magnetic resonance arthrograms in 3 of the 5 cases that were found to have multiple tendons during surgery. None of these were recognized before the procedures. In this series the surgeon intentionally looked for multiple tendons, which were found in 17.85% of the cases. Clinical results in patients with single- and multiple-tendon snapping seem to be similarly adequate

Synaptosome-Associated Protein 25 (SNAP25) Gene Association Analysis Revealed Risk Variants for ASD, in Iranian Population.

PubMed

Safari, Mohammad Reza; Omrani, Mir Davood; Noroozi, Rezvan; Sayad, Arezou; Sarrafzadeh, Shaghayegh; Komaki, Alireza; Manjili, Fateme Asadzadeh; Mazdeh, Mehrdokht; Ghaleiha, Ali; Taheri, Mohammad

2017-03-01

Autism spectrum disorder (ASD) is a common, complex neurological condition, affecting approximately 1% of people worldwide. Monogenic neurodevelopmental disorders which showed autistic behavior patterns have suggested synaptic dysfunction, as a key mechanism in the pathophysiology of ASD. Subsequently, genes involved in synaptic signaling have been investigated with a priority for candidate gene studies. A synaptosomal-associated protein 25 (SNAP25) gene plays a crucial role in the central nervous system, contributing to exocytosis by targeting and fusion of vesicles to the cell membrane. Studies have shown a correlation between aberrant expression of the SNAP25 and a variety of brain diseases. Single nucleotide polymorphisms (SNPs) in this gene are associated with several psychiatric diseases, such as bipolar, schizophrenia, and attention-deficit/hyperactivity disorder. The aim of the present study was to investigate whether polymorphisms (rs3746544 and rs1051312) in the regulatory 3'-untranslated region (3'UTR) of the SNAP25 gene have an association with ASD in unrelated Iranian case (N = 524)-control (N = 472) samples. We observed robust association of the rs3746544 SNP and ASD patients, in both allele and haplotype-based analyses. Our results supported the previous observations and indicated a possible role for SNAP25 polymorphisms as susceptibility genetic factors involved in developing ASD.

A role for SNAP-25 but not VAMPs in store-mediated Ca2+ entry in human platelets

PubMed Central

Redondo, Pedro C; Harper, Alan G S; Salido, Ginés M; Pariente, Jose A; Sage, Stewart O; Rosado, Juan A

2004-01-01

Store-mediated Ca2+ entry (SMCE) is a major mechanism for Ca2+ influx in non-excitable cells. Recently, a conformational coupling mechanism allowing coupling between transient receptor potential channels (TRPCs) and IP3 receptors has been proposed to activate SMCE. Here we have investigated the role of two soluble N-ethylmaleimide-sensitive-factor attachment protein receptors (SNAREs), which are involved in membrane trafficking and docking, in SMCE in human platelets. We found that the synaptosome-associated protein (SNAP-25) and the vesicle-associated membrane proteins (VAMP) coimmunoprecipitate with hTRPC1 in platelets. Treatment with botulinum toxin (BoNT) E or with tetanus toxin (TeTx), induced cleavage and inactivation of SNAP-25 and VAMPs, respectively. BoNTs significantly reduced thapsigargin- (TG) and agonist-evoked SMCE. Treatment with BoNTs once SMCE had been activated decreased Ca2+ entry, indicating that SNAP-25 is required for the activation and maintenance of SMCE. In contrast, treatment with TeTx had no effect on either the activation or the maintenance of SMCE in platelets. Finally, treatment with BoNT E impaired the coupling between naturally expressed hTRPC1 and IP3 receptor type II in platelets. From these findings we suggest SNAP-25 has a role in SMCE in human platelets. PMID:15121806

Rapid Contour-based Segmentation for 18F-FDG PET Imaging of Lung Tumors by Using ITK-SNAP: Comparison to Expert-based Segmentation.

PubMed

Besson, Florent L; Henry, Théophraste; Meyer, Céline; Chevance, Virgile; Roblot, Victoire; Blanchet, Elise; Arnould, Victor; Grimon, Gilles; Chekroun, Malika; Mabille, Laurence; Parent, Florence; Seferian, Andrei; Bulifon, Sophie; Montani, David; Humbert, Marc; Chaumet-Riffaud, Philippe; Lebon, Vincent; Durand, Emmanuel

2018-04-03

Purpose To assess the performance of the ITK-SNAP software for fluorodeoxyglucose (FDG) positron emission tomography (PET) segmentation of complex-shaped lung tumors compared with an optimized, expert-based manual reference standard. Materials and Methods Seventy-six FDG PET images of thoracic lesions were retrospectively segmented by using ITK-SNAP software. Each tumor was manually segmented by six raters to generate an optimized reference standard by using the simultaneous truth and performance level estimate algorithm. Four raters segmented 76 FDG PET images of lung tumors twice by using ITK-SNAP active contour algorithm. Accuracy of ITK-SNAP procedure was assessed by using Dice coefficient and Hausdorff metric. Interrater and intrarater reliability were estimated by using intraclass correlation coefficients of output volumes. Finally, the ITK-SNAP procedure was compared with currently recommended PET tumor delineation methods on the basis of thresholding at 41% volume of interest (VOI; VOI 41 ) and 50% VOI (VOI 50 ) of the tumor's maximal metabolism intensity. Results Accuracy estimates for the ITK-SNAP procedure indicated a Dice coefficient of 0.83 (95% confidence interval: 0.77, 0.89) and a Hausdorff distance of 12.6 mm (95% confidence interval: 9.82, 15.32). Interrater reliability was an intraclass correlation coefficient of 0.94 (95% confidence interval: 0.91, 0.96). The intrarater reliabilities were intraclass correlation coefficients above 0.97. Finally, VOI 41 and VOI 50 accuracy metrics were as follows: Dice coefficient, 0.48 (95% confidence interval: 0.44, 0.51) and 0.34 (95% confidence interval: 0.30, 0.38), respectively, and Hausdorff distance, 25.6 mm (95% confidence interval: 21.7, 31.4) and 31.3 mm (95% confidence interval: 26.8, 38.4), respectively. Conclusion ITK-SNAP is accurate and reliable for active-contour-based segmentation of heterogeneous thoracic PET tumors. ITK-SNAP surpassed the recommended PET methods compared with ground truth

The SNaP system: biomechanical and animal model testing of a novel ultraportable negative-pressure wound therapy system.

PubMed

Fong, Kenton D; Hu, Dean; Eichstadt, Shaundra; Gupta, Deepak M; Pinto, Moshe; Gurtner, Geoffrey C; Longaker, Michael T; Lorenz, H Peter

2010-05-01

Negative-pressure wound therapy is traditionally achieved by attaching an electrically powered pump to a sealed wound bed and applying subatmospheric pressure by means of gauze or foam. The Smart Negative Pressure (SNaP) System (Spiracur, Inc., Sunnyvale, Calif.) is a novel ultraportable negative-pressure wound therapy system that does not require an electrically powered pump. Negative pressure produced by the SNaP System, and a powered pump, the wound vacuum-assisted closure advanced-therapy system (Kinetic Concepts, Inc., San Antonio, Texas), were compared in vitro using bench-top pressure sensor testing and microstrain and stress testing with pressure-sensitive film and micro-computed tomographic scan analysis. In addition, to test in vivo efficacy, 10 rats underwent miniaturized SNaP (mSNaP) device placement on open wounds. Subject rats were randomized to a system activation group (approximately -125 mmHg) or a control group (atmospheric pressure). Wound measurements and histologic data were collected for analysis. Bench measurement revealed nearly identical negative-pressure delivery and mechanical strain deformation patterns between both systems. Wounds treated with the mSNaP System healed faster, with decreased wound size by postoperative day 7 (51 percent versus 12 percent reduction; p < 0.05) and had more rapid complete reepithelialization (21 days versus 32 days; p < 0.05). The mSNaP device also induced robust granulation tissue formation. The SNaP System and an existing electrically powered negative-pressure wound therapy system have similar biomechanical properties and functional wound-healing benefits. The potential clinical efficacy of the SNaP device for the treatment of wounds is supported.

Towards Lego Snapping; Integration of Carbon Nanotubes and Few-Layer Graphene

NASA Astrophysics Data System (ADS)

Nasseri, Mohsen; Boland, Mathias; Farrokhi, M. Javad; Strachan, Douglas

Integration of semiconducting, conducting, and insulating nanomaterials into precisely aligned complicated systems is one of the main challenges to the ultimate size scaling of electronic devices, which is a key goal in nanoscience and nanotechnology. This integration could be made more effective through controlled alignment of the crystallographic lattices of the nanoscale components. Of the vast number of materials of atomically-thin materials, two of the sp2 bonded carbon structures, graphene and carbon nanotubes, are ideal candidates for this type of application since they are built from the same backbone carbon lattice. Here we report carbon nanotube and graphene hybrid nanostructures fabricated through their catalytic synthesis and etching. The growth formations we have investigated through various high-resolution microscopy techniques provide evidence of lego-snapped interfaces between nanotubes and graphene into device-relevant orientations. We will finish with a discussion of the various size and energy regimes relevant to these lego-snapped interfaces and their implications on developing these integrated formations.

7 CFR 1962.6 - Liens and assignments on chattel property.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., RURAL BUSINESS-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT OF... Security § 1962.6 Liens and assignments on chattel property. (a) Chattel property not covered by Agency... borrower, a crop lien will be taken as additional security when the County Supervisor determines in...

A Pilot Study of the Snap & Sniff Threshold Test.

PubMed

Jiang, Rong-San; Liang, Kai-Li

2018-05-01

The Snap & Sniff ® Threshold Test (S&S) has been recently developed to determine the olfactory threshold. The aim of this study was to further evaluate the validity and test-retest reliability of the S&S. The olfactory thresholds of 120 participants were determined using both the Smell Threshold Test (STT) and the S&S. The participants included 30 normosmic volunteers and 90 patients (60 hyposmic, 30 anosmic). The normosmic participants were retested using the STT and S&S at an intertest interval of at least 1 day. The mean olfactory threshold determined with the S&S was -6.76 for the normosmic participants, -3.79 for the hyposmic patients, and -2 for the anosmic patients. The olfactory thresholds were significantly different across the 3 groups ( P < .001). Snap & Sniff-based and STT-based olfactory thresholds were correlated weakly in the normosmic group (correlation coefficient = 0.162, P = .391) but more strongly correlated in the patient groups (hyposmic: correlation coefficient = 0.376, P = .003; anosmic: correlation coefficient = 1.0). The test-retest correlation for the S&S-based olfactory thresholds was 0.384 ( P = .036). Based on validity and test-retest reliability, we concluded that the S&S is a proper test for olfactory thresholds.

Reduction in Thrombosis and Bacterial Adhesion with 7 Day Implantation of S-Nitroso-N-acetylpenicillamine (SNAP)-Doped Elast-eon E2As Catheters in Sheep

PubMed Central

Brisbois, Elizabeth J.; Davis, Ryan P.; Jones, Anna M.; Major, Terry C.; Bartlett, Robert H.; Meyerhoff, Mark E.; Handa, Hitesh

2015-01-01

Thrombosis and infection are two common problems associated with blood-contacting medical devices such as catheters. Nitric oxide (NO) is known to be a potent antimicrobial agent as well as an inhibitor of platelet activation and adhesion. Healthy endothelial cells that line the inner walls of all blood vessels exhibit a NO flux of 0.5~4×10−10 mol cm−2 min−1 that helps prevent thrombosis. Materials with a NO flux that is equivalent to this level are expected to exhibit similar anti-thrombotic properties. In this study, NO-releasing catheters were fabricated by incorporating S-nitroso-N-acetylpenicillamine (SNAP) in the Elast-eon E2As polymer. The SNAP/E2As catheters release physiological levels of NO for up to 20 d, as measured by chemiluminescence. Furthermore, SNAP is stable in the E2As polymer, retaining 89% of the initial SNAP after ethylene oxide (EO) sterilization. The SNAP/E2As and E2As control catheters were implanted in sheep veins for 7 d to examine the effect on thrombosis and bacterial adhesion. The SNAP/E2As catheters reduced the thrombus area when compared to the control (1.56 ± 0.76 and 5.06 ± 1.44 cm2, respectively). A 90% reduction in bacterial adhesion was also observed for the SNAP/E2As catheters as compared to the controls. The results suggest that the SNAP/E2As polymer has the potential to improve the hemocompatibility and bactericidal activity of intravascular catheters, as well as other blood-contacting medical devices (e.g., vascular grafts, extracorporeal circuits). PMID:25685358

SU-F-J-25: Position Monitoring for Intracranial SRS Using BrainLAB ExacTrac Snap Verification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jang, S; McCaw, T; Huq, M

2016-06-15

Purpose: To determine the accuracy of position monitoring with BrainLAB ExacTrac snap verification following couch rotations during intracranial SRS. Methods: A CT scan of an anthropomorphic head phantom was acquired using 1.25mm slices. The isocenter was positioned near the centroid of the frontal lobe. The head phantom was initially aligned on the treatment couch using cone-beam CT, then repositioned using ExacTrac x-ray verification with residual errors less than 0.2mm and 0.2°. Snap verification was performed over the full range of couch angles in 15° increments with known positioning offsets of 0–3mm applied to the phantom along each axis. At eachmore » couch angle, the smallest tolerance was determined for which no positioning deviation was detected. Results: For couch angles 30°–60° from the center position, where the longitudinal axis of the phantom is approximately aligned with the beam axis of one x-ray tube, snap verification consistently detected positioning errors exceeding the maximum 8mm tolerance. Defining localization error as the difference between the known offset and the minimum tolerance for which no deviation was detected, the RMS error is mostly less than 1mm outside of couch angles 30°–60° from the central couch position. Given separate measurements of patient position from the two imagers, whether to proceed with treatment can be determined by the criterion of a reading within tolerance from just one (OR criterion) or both (AND criterion) imagers. Using a positioning tolerance of 1.5mm, snap verification has sensitivity and specificity of 94% and 75%, respectively, with the AND criterion, and 67% and 93%, respectively, with the OR criterion. If readings exceeding maximum tolerance are excluded, the sensitivity and specificity are 88% and 86%, respectively, with the AND criterion. Conclusion: With a positioning tolerance of 1.5mm, ExacTrac snap verification can be used during intracranial SRS with sensitivity and specificity

Non-target captures during small mammal trapping with snap traps

Treesearch

David G. Peitz; Philip A. Tappe; Ronald E. Thill; Roger W. Perry; M. Anthony Melchiors; T. Bently Wigley

2001-01-01

There is little published information available on non-target captures during small mammal trapping. We used a variety of snap traps baited with a rolled oat-peanut butter mix to capture 2,054 individuals from 9 genera of small mammals in a study of small mammal and avian community structure in riparian areas and adjacent loblolly pine (Pinus taeda) plantations. We...

REPORT OF THE QUALIFICATION TESTING OF SNAP 10A FUSISTORS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holtwick, J.S. III; Nowell, V.P.

1963-07-31

Qualification testing of SNAP 10A fusistors was performed. Test operations included: visual inspection, insulation resistance, dielectric strength, and d-c resistance testing prior to subjecting the fusisters to environmental testing; opening-time testing prior to, during, and following vacuum and temperature testing; and insulation resistance, dielectric strength, and d-c resistance testing following environmental applications of temperature, vacuum, and sinusoidal vibration. (auth)

A Comparison of Snap Traps for Evaluating Small Mammal Populations

Treesearch

Roger W. Perry; Philip A. Tappe; David G. Peitz; Ronald E. Thill; M. Anthony Melchoirs; T. Bently Wigley

1996-01-01

The authors compared rat, mouse, and museum special snap traps to determine if differences existed in capture efficiency of small mammals and whether type of trap affected indices of richness, evenness, and diversity. Small mammals were trapped in 57 streamside study areas in 1990 to 1995 in the Ouachita Mountains, AR. Efficiency of mouse traps was equal to or greater...

Nonlinear modes of snap-through motions of a shallow arch

NASA Astrophysics Data System (ADS)

Breslavsky, I.; Avramov, K. V.; Mikhlin, Yu.; Kochurov, R.

2008-03-01

Nonlinear modes of snap-through motions of a shallow arch are analyzed. Dynamics of shallow arch is modeled by a two-degree-of-freedom system. Two nonlinear modes of this discrete system are treated. The methods of Ince algebraization and Hill determinants are used to study stability of nonlinear modes. The analytical results are compared with the data of the numerical simulations.

On the presence of plutonium in Madagascar following the SNAP-9A satellite failure.

PubMed

Rääf, C; Holm, E; Rabesiranana, N; Garcia-Tenorio, R; Chamizo, E

2017-10-01

This study examined the 238 Pu and 239+240 Pu activity concentration and the 240 Pu/ 239 Pu atomic ratio in peat bogs sampled in 2012 from marshlands in central Madagascar. The purpose was to investigate the presence of plutonium isotopes, 238, 239, 240 Pu, from the 1964 satellite failure carrying a SNAP-9A radiothermal generator. With an average 238 Pu/ 239+240 Pu activity ratio of 0.165 ± 0.02 (decay corrected to 1964), the peat bogs in Madagascar exhibit similar values as the ones found in the southeastern African continent, except they are one order of magnitude higher than expected (0.025) from global fallout in the Southern Hemisphere. The 240 Pu/ 239 Pu atomic ratio showed a distinct decrease for layers dating back to the mid-1960s (down to 0.069 compared with an anticipated ratio of 0.17 for global fallout), indicating that the SNAP-9A failure also resulted in an elevated deposition of 239 Pu. The obtained results demonstrate that further Pu analysis in Madagascar and in southeastern continental Africa is necessary to fully account for the regional Pu deposition from the SNAP-9A event. Copyright © 2017 Elsevier Ltd. All rights reserved.

34. Photographic copy of photograph (ca. 1962, original print in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

34. Photographic copy of photograph (ca. 1962, original print in possession of Army Corps of Engineers, Ft. Belvoir, Virginia) Photographer unknown. View of launch control facility under construction, security gate at left - Ellsworth Air Force Base, Delta Flight, 10 mile radius around Exit 127 off Interstate 90, Interior, Jackson County, SD

7 CFR 1962.19 - Claims against Commodity Credit Corporation (CCC).

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 14 2013-01-01 2013-01-01 false Claims against Commodity Credit Corporation (CCC... Liquidation of Chattel Security § 1962.19 Claims against Commodity Credit Corporation (CCC). This section is based on a Memorandum of Understanding between CCC and FmHA or its successor agency under Public Law 103...

7 CFR 1962.19 - Claims against Commodity Credit Corporation (CCC).

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 14 2014-01-01 2014-01-01 false Claims against Commodity Credit Corporation (CCC... Liquidation of Chattel Security § 1962.19 Claims against Commodity Credit Corporation (CCC). This section is based on a Memorandum of Understanding between CCC and FmHA or its successor agency under Public Law 103...

7 CFR 1962.19 - Claims against Commodity Credit Corporation (CCC).

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 14 2012-01-01 2012-01-01 false Claims against Commodity Credit Corporation (CCC... Liquidation of Chattel Security § 1962.19 Claims against Commodity Credit Corporation (CCC). This section is based on a Memorandum of Understanding between CCC and FmHA or its successor agency under Public Law 103...

7 CFR 1962.19 - Claims against Commodity Credit Corporation (CCC).

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 14 2010-01-01 2009-01-01 true Claims against Commodity Credit Corporation (CCC... Liquidation of Chattel Security § 1962.19 Claims against Commodity Credit Corporation (CCC). This section is based on a Memorandum of Understanding between CCC and FmHA or its successor agency under Public Law 103...

7 CFR 1962.19 - Claims against Commodity Credit Corporation (CCC).

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 14 2011-01-01 2011-01-01 false Claims against Commodity Credit Corporation (CCC... Liquidation of Chattel Security § 1962.19 Claims against Commodity Credit Corporation (CCC). This section is based on a Memorandum of Understanding between CCC and FmHA or its successor agency under Public Law 103...

The role of SNAP in home food availability and dietary intake among WIC participants facing unstable housing

PubMed Central

Bruening, Meg; McClain, Darya; Moramarco, Michael; Reifsnider, Elizabeth

2016-01-01

Objective Little nutrition research has been conducted among families with unstable housing. The objective of this study was to examine the role of food stamps (i.e. Supplemental Nutrition Assistance Program; SNAP) in home food availability and dietary intake among WIC families who experienced unstable housing. Design Cross-sectional study among vulnerable families. Sample Low-income, multi-ethnic families with children participating in WIC (n=54). Measurements Dietary intake was assessed with 24-hour recalls. Home food availability was assessed with an adapted home food inventory for low-income, multi-ethnic families. Validation results from adapted home food inventory for these families are also reported. Results SNAP households had more foods than non-SNAP households; few significant associations were observed between food availability and child dietary intake. Conclusions With few exceptions, the home food environment was not related to children’s dietary intake among these vulnerable families. More research is needed on food access for families facing unstable housing. PMID:28084013

The Snapping Elbow Syndrome as a Reason for Chronic Elbow Neuralgia in a Tennis Player - MR, US and Sonoelastography Evaluation.

PubMed

Łasecki, Mateusz; Olchowy, Cyprian; Pawluś, Aleksander; Zaleska-Dorobisz, Urszula

2014-01-01

Ulnar neuropathy is the second most common peripheral nerve neuropathy after median neuropathy, with an incidence of 25 cases per 100 000 men and 19 cases per 100 000 women each year. Skipping (snapping) elbow syndrome is an uncommon cause of pain in the posterior-medial elbow area, sometimes complicated by injury of the ulnar nerve. One of the reason is the dislocation of the abnormal insertion of the medial triceps head over the medial epicondyle during flexion and extension movements. Others are: lack of the Osboune fascia leading to ulnar nerve instability and focal soft tissue tumors (fibromas, lipomas, etc). Recurrent subluxation of the nerve at the elbow results in a tractional and frictional neuritis with classical symptoms of peripheral neuralgia. As far as we know snapping triceps syndrome had never been evaluated in sonoelastography. A 28yo semi-professional left handed tennis player was complaining about pain in posterior-medial elbow area. Initial US examination suggest golfers elbow syndrome which occurs quite commonly and has a prevalence of 0.3-0.6% in males and 0-3-1.1% in women and may be associated (approx. 50% of cases) with ulnar neuropathy. However subsequently made MRI revealed unusual distal triceps anatomy, moderate ulnar nerve swelling and lack of medial epicondylitis symptoms. Followed (second) US examination and sonoelastography have detected slipping of the both ulnar nerve and the additional band of the medial triceps head. Snapping elbow syndrome is a poorly known medical condition, sometimes misdiagnosed as the medial epicondylitis. It describes a broad range of pathologies and anatomical abnormalities. One of the most often reasons is the slipping of the ulnar nerve as the result of the Osborne fascia/anconeus epitrochlearis muscle absence. Simultaneously presence of two or more "snapping reasons" is rare but should be always taken under consideration. There are no sonoelastography studies describing golfers elbow syndrome

Scrotal cancer in the north-west of England, 1962-68

PubMed Central

Lee, W. R.; Alderson, M. R.; Downes, Jean E.

1972-01-01

Lee, W. R., Alderson, M. R., and Downes, J. E. (1972).Brit. J. industr. Med.,29, 188-195. Scrotal cancer in the north-west of England, 1962-68. During the seven years 1962 to 1968 there were 103 cases of scrotal cancer reported to the Manchester Regional Cancer Registry. It was possible to obtain reasonably full occupational histories concerning 89 of these cases either from the men themselves or from close relatives. Fifty-one had been mule spinners, 40 of whom had worked in no other industry with a hazard of scrotal cancer, but the other 11 had. Another 19 men had never been mule spinners but had worked in occupations with a recognized hazard of this condition. Of the remainder, 14 had worked in occupations with a possible risk, although perhaps not generally recognized as such, and in five no clear cause was apparent. Because of the small numbers, it was possible to compare the observed and expected incidences only in broad occupational groups and these showed a statistically significant excess (P<0·001) only in textile workers and unskilled workers. However, our findings, taken with those of earlier workers, suggest that further attention might be given to four other groups, namely, automatic lathe operators, road workers, dye workers, and chain makers. Cancer of the scrotum tends to be a disease of the elderly. In 42% of men (other than mule spinners) scrotal cancer developed after the men had passed the age of retirement and therefore too late for routine medical examination at the workplace to be of any value. Fifty of the men had died, but scrotal cancer was registered as the underlying cause in only 19 and appeared on the death certificate in a further four. PMID:5063206

7 CFR 1962.27 - Termination or satisfaction of chattel security instruments.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 14 2010-01-01 2009-01-01 true Termination or satisfaction of chattel security... and Liquidation of Chattel Security § 1962.27 Termination or satisfaction of chattel security...) Filing or recording satisfactions. Satisfactions of chattel mortgages and similar instruments will be...

SNAP Participation in Preschool-Aged Children and Prevalence of Overweight and Obesity

ERIC Educational Resources Information Center

Simmons, Shannon; Alexander, Jeffrey L.; Ewing, Helen; Whetzel, Stephanie

2012-01-01

Background: An increased prevalence of overweight and obesity for adults on government-funded nutrition assistance, such as the Supplemental Nutrition Assistance Program (SNAP), has been observed; however, this association among preschool-aged children is not well understood. Longitudinal research designs tracking changes in body mass…

Photographic copy of construction drawing, dated October 19, 1962, Department ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photographic copy of construction drawing, dated October 19, 1962, Department of the Air Force Air Defense Command Installations, in possession of Selfridge Base Museum, Mt. Clemens, Michigan. ALTER POL OPERATIONS, SHEET 1 OF 2, SLF 140-070 - Selfridge Field, Building No. 1445, Sugarbush Road north of Bunker Road, Mount Clemens, Macomb County, MI

The Australian National Sub-acute and Non-acute Patient Casemix Classification (AN-SNAP): its application and value in a stroke rehabilitation programme.

PubMed

Lowthian, P; Disler, P; Ma, S; Eagar, K; Green, J; de Graaff, S

2000-10-01

To investigate whether the Australian National Sub-acute and Non-acute Patient Casemix Classification (SNAP) and Functional Independence Measure and Functional Related Group (Version 2) (FIM-FRG2) casemix systems can be used to predict functional outcome, and reduce the variance of length of stay (LOS) of patients undergoing rehabilitation after strokes. The study comprised a retrospective analysis of the records of patients admitted to the Cedar Court Healthsouth Rehabilitation Hospital for rehabilitation after stroke. The sample included 547 patients (83.3% of those admitted with stroke during this period). Patient data were stratified for analysis into the five SNAP or nine FIM-FRG2 groups, on the basis of the admission FIM scores and age. The AN-SNAP classification accounted for a 30.7% reduction of the variance of LOS, and 44.2% of motor FIM, and the FIM-FRG2 accounts for 33.5% and 56.4% reduction respectively. Comparison of the Cedar Court with the national AN-SNAP data showed differences in the LOS and functional outcomes of older, severely disabled patients. Intensive rehabilitation in selected patients of this type appears to have positive effects, albeit with a slightly longer period of inpatient rehabilitation. Casemix classifications can be powerful management tools. Although FIM-FRG2 accounts for more reduction in variance than SNAP, division into nine groups meant that some contained few subjects. This paper supports the introduction of AN-SNAP as the standard casemix tool for rehabilitation in Australia, which will hopefully lead to rational, adequate funding of the rehabilitation phase of care.

Temporal fluctuations and frontal area change of Bangni and Dunagiri glaciers from 1962 to 2013, Dhauliganga Basin, central Himalaya, India

NASA Astrophysics Data System (ADS)

Kumar, Vinit; Mehta, Manish; Mishra, Ajai; Trivedi, Anjali

2017-05-01

Glaciers have been receding for the last 100 years in many glaciated regions of the world, and the rate of recession has accelerated during the last 60 years. Recent assessments of changes in glaciers in the Himalaya have usually recognized their variable rate of recession. The present study deals with snout retreat, frontal area vacation, and estimation of the equilibrium line altitude (ELA) of Bangni and Dunagiri glaciers, in the Dhauliganga Basin, central Himalaya (India), using multi-image satellite data (Landsat MSS, 1976; Landsat TM, 1990; Landsat ETM +, 2005) and Survey of India topographic maps (1962; 1:50,000) along with field surveys (2012 to 2014) for the period of 1962-2013. The meteorological data of the India Meteorological Department (IMD) and TRMM suggested that the central Himalaya received less precipitation between 1960 and 1990. Because of the less precipitation, glaciers receded rapidly during this period. The present study shows that Bangni and Dunagiri glaciers retreated 2080 ± 162 m and 484 ± 38 m with average rates of 41 ± 3.2 m a- 1 and 9 ± 0.6 m a- 1 between 1962 and 2013, respectively. During this period Bangni and Dunagiri glaciers lost about 17% and 11% of their length, respectively. The result also suggested that Bangni Glacier vacated 598,948 ± 12,257 m2 frontal area, while Dunagiri Glacier vacated 170,428 ± 7833 m2 frontal area between 1962 and 2013. Moreover, the estimated ELA change for Bangni Glacier was 64 ± 30 m upward during the study period. The Geological Survey of India (GSI, 1998a,b) suggested that the ELA of Dunagiri Glacier rose 28 m between 1984 and 1992 and that the glacier lost (-)16 × 106 m3 w.e. ice with an average rate of loss of (-)1.04 m w.e. a- 1. The geomorphology of the Dunagiri Valley reflected that Bangni and Dunagiri glaciers were joined together in the past. Nevertheless, these two glaciers retreat at different rates, indicating that climate change is not the only factor in glacier retreat but that

Phosphorylation of SNAP-23 at Ser95 causes a structural alteration and negatively regulates Fc receptor-mediated phagosome formation and maturation in macrophages.

PubMed

Sakurai, Chiye; Itakura, Makoto; Kinoshita, Daiki; Arai, Seisuke; Hashimoto, Hitoshi; Wada, Ikuo; Hatsuzawa, Kiyotaka

2018-05-17

SNAP-23 is a plasma membrane-localized SNARE protein involved in Fc receptor (FcR)-mediated phagocytosis. However, the regulatory mechanism underlying its function remains elusive. Using phosphorylation specific-antibodies, SNAP-23 was found to be phosphorylated at Ser95 in macrophages. To understand the role of this phosphorylation, we established macrophage lines overexpressing the non-phosphorylatable S95A or the phospho-mimicking S95D mutation. The efficiency of phagosome formation and maturation was severely reduced in SNAP-23-S95D-overexpressing cells. To examine whether phosphorylation at Ser95 affected SNAP-23 structure, we constructed intramolecular Förster resonance energy transfer (FRET) probes of SNAP-23 designed to evaluate the approximation of the N-termini of the two SNARE motifs. Interestingly, a high FRET efficiency was detected on the membrane when the S95D probe was used, indicating that phosphorylation at Ser95 caused a dynamic structural shift to the closed form. Co-expression of IκB kinase (IKK) 2 enhanced the FRET efficiency of the wild-type probe on the phagosome membrane. Furthermore, the enhanced phagosomal FRET signal in interferon-γ-activated macrophages was largely dependent on IKK2, and this kinase mediated a delay in phagosome-lysosome fusion. These results suggested that SNAP-23 phosphorylation at Ser95 played an important role in the regulation of SNARE-dependent membrane fusion during FcR-mediated phagocytosis.

Aerial photo SBVC1962". Photo no. 360. Low oblique aerial view ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Aerial photo -SBVC-1962". Photo no. 360. Low oblique aerial view of the campus, looking southeast. Stamped on the rear: "Ron Wilhite, Sun-Telegram photo, file, 10/22/62/ - San Bernardino Valley College, 701 South Mount Vernon Avenue, San Bernardino, San Bernardino County, CA

43. Photographic copy of photograph (ca. 1962, original print in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

43. Photographic copy of photograph (ca. 1962, original print in possession of Peter Kiewit Sons' Co., Omaha, Nebraska) Photographer unknown. View of launch closure, launch closure apron at left, personnel access hatch open at right - Ellsworth Air Force Base, Delta Flight, 10 mile radius around Exit 127 off Interstate 90, Interior, Jackson County, SD

How the Venus flytrap actively snaps: hydrodynamic measurements at the cellular level

NASA Astrophysics Data System (ADS)

Colombani, Mathieu; Forterre, Yoel; GEP Team

2012-11-01

Although they lack muscle, plants have evolved a remarkable range of mechanisms to create rapid motion, from the rapid folding of sensitive plants to seed dispersal. Of these spectacular examples that have long fascinated scientists, the carnivorous plant Venus flytrap, whose leaves snap together in a fraction of second to capture insects, has long been a paradigm for study. Recently, we have shown that this motion involves a snap-buckling instability due to the shell-like geometry of the leaves of the trap. However, the origin of the movement that allows the plant to cross the instability threshold and actively bend remains largely unknown. In this study, we investigate this active motion using a micro-fluidic pressure probe that gives direct hydraulic and mechanical measurements at the cellular level (osmotic pressure, cell membrane permeability, cell wall elasticity). Our results challenge the role of osmotically-driven water flows usually put forward to explain Venus flytrap's active closure.

A cosmic X-ray astronomy bibliography: The Astrophysical Journal, 1962 to 1972

NASA Technical Reports Server (NTRS)

Wilson, R. M.

1972-01-01

The results are presented of a survey of the Astrophysical Journal for the period January 1962 through March 1972 (volumes 135-172). Some 395 references are contained within this document related to cosmic X-ray astronomy.

Wood products used in constructing conservation and development projects by the Corps of Engineers in the United States, 1962 and 1978

Treesearch

W. H. Reid; D. B. McKeever

Estimates of the amounts of wood products used in constructing civil conservation and development projects by the Corps of Engineers in the United States are presented for the years 1962 and 1978. Amounts of lumber, laminated lumber, poles and piling, and plywood used in construction are stratified by five construction categories, and three types of uses. Estimates of...

Geometrically controlled snapping transitions in shells with curved creases.

PubMed

Bende, Nakul Prabhakar; Evans, Arthur A; Innes-Gold, Sarah; Marin, Luis A; Cohen, Itai; Hayward, Ryan C; Santangelo, Christian D

2015-09-08

Curvature and mechanics are intimately connected for thin materials, and this coupling between geometry and physical properties is readily seen in folded structures from intestinal villi and pollen grains to wrinkled membranes and programmable metamaterials. While the well-known rules and mechanisms behind folding a flat surface have been used to create deployable structures and shape transformable materials, folding of curved shells is still not fundamentally understood. Shells naturally deform by simultaneously bending and stretching, and while this coupling gives them great stability for engineering applications, it makes folding a surface of arbitrary curvature a nontrivial task. Here we discuss the geometry of folding a creased shell, and demonstrate theoretically the conditions under which it may fold smoothly. When these conditions are violated we show, using experiments and simulations, that shells undergo rapid snapping motion to fold from one stable configuration to another. Although material asymmetry is a proven mechanism for creating this bifurcation of stability, for the case of a creased shell, the inherent geometry itself serves as a barrier to folding. We discuss here how two fundamental geometric concepts, creases and curvature, combine to allow rapid transitions from one stable state to another. Independent of material system and length scale, the design rule that we introduce here explains how to generate snapping transitions in arbitrary surfaces, thus facilitating the creation of programmable multistable materials with fast actuation capabilities.

S-Nitroso-N-acetylpenicillamine (SNAP) Impregnated Silicone Foley Catheters: A Potential Biomaterial/Device To Prevent Catheter-Associated Urinary Tract Infections

PubMed Central

2016-01-01

Urinary Foley catheters are utilized for management of hospitalized patients and are associated with high rates of urinary tract infections (UTIs). Nitric oxide (NO) potently inhibits microbial biofilm formation, which is the primary cause of catheter associated UTIs (CAUTIs). Herein, commercial silicone Foley catheters are impregnated via a solvent swelling method with S-nitroso-N-acetyl-D-penicillamine (SNAP), a synthetic NO donor that exhibits long-term NO release and stability when incorporated into low water-uptake polymers. The proposed catheters generate NO surface-fluxes >0.7 × 10–10 mol min–1 cm–2 for over one month under physiological conditions, with minimal SNAP leaching. These biomedical devices are demonstrated to significantly decrease formation of biofilm on the surface of the catheter tubings over 3, 7, and 14 day periods by microbial species (Staphylococcus epidermidis and Proteus mirabilis) commonly causing CAUTIs. Toxicity assessment demonstrates that the SNAP-impregnated catheters are fully biocompatible, as extracts of the catheter tubings score 0 on a 3-point grading scale using an accepted mouse fibroblast cell-line toxicity model. Consequently, SNAP-impregnated silicone Foley catheters can likely provide an efficient strategy to greatly reduce the occurrence of nosocomial CAUTIs. PMID:26462294

8. Photographic copy of construction drawing, dated January 10, 1962, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Photographic copy of construction drawing, dated January 10, 1962, Department of the Air Force Air Defense Command Installations for Selfridge, in possession of Selfridge Base Museum, Mt. Clemens, Michigan. ELEVATIONS AND SECTIONS, SLF 140-056 SHEET 3 OF 7. - Selfridge Field, Building No. 562, Ammo Road northeast of Taxiway A, Mount Clemens, Macomb County, MI

7. Photographic copy of construction drawing, dated January 10, 1962, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Photographic copy of construction drawing, dated January 10, 1962, Department of the Air Force Air Defense Command Installations for Selfridge, in possession of Selfridge Base Museum, Mt. Clemens, Michigan. ARCHITECTURAL PLAN AND SCHEDULES, SLF 140-056, SHEET 2 OF 7. - Selfridge Field, Building No. 562, Ammo Road northeast of Taxiway A, Mount Clemens, Macomb County, MI

19. Photographic copy of photograph (ca. 1962, original print in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. Photographic copy of photograph (ca. 1962, original print in possession of Peter Kiewit Sons' Co., Omaha, Nebraska) Photographer unknown. Road signs for Alpha Flight Launch Facility sites 8-11 and Bravo Flight Launch Facility sites 2 and 11 - Ellsworth Air Force Base, Delta Flight, 10 mile radius around Exit 127 off Interstate 90, Interior, Jackson County, SD

Continuing Lessons of the Cuban Missile Crisis, October 1962,

DTIC Science & Technology

1995-04-14

natiornal interests. Both sides had steadfastly marched to the edge of the precipice overlooking nuclear war, and had stepped back; staunchly determined to...contention is that the event is steeped in heavy, almost cinematic drama, "A vividness and excitement unmatched by almost any other post-war event...Locka, Florida on 15 March 1962 (thirteen separate federal agencies were vying to interview each refugee). Known as the Caribbean Admission Center

Parent and Teacher SNAP-IV Ratings of Attention Deficit Hyperactivity Disorder Symptoms: Psychometric Properties and Normative Ratings from a School District Sample

ERIC Educational Resources Information Center

Bussing, Regina; Fernandez, Melanie; Harwood, Michelle; Hou, Wei; Garvan, Cynthia Wilson; Eyberg, Sheila M.; Swanson, James M.

2008-01-01

To examine Swanson, Nolan, and Pelham-IV (SNAP-IV) psychometric properties, parent (N = 1,613) and teacher (N = 1,205) data were collected from a random elementary school student sample in a longitudinal attention deficit hyperactivity disorder (ADHD) detection study. SNAP-IV reliability was acceptable. Factor structure indicated two ADHD factors…

Research at Lincoln Laboratory leading up to the development of the injection laser in 1962

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rediker, R.H.

1987-06-01

In 1958 the semiconductor device group at Lincoln Laboratory began to concentrate its efforts on exploiting GaAs. These efforts, in addition to yielding diodes with ns switching speeds, led to the development in early 1962 of diodes which emitted near-bandgap radiation with very high efficiency, and to the development in October 1962 of the diode laser. The theory of the semiconductor laser developed at Lincoln Laboratory in the mid-to-late 1950's provided the foundation necessary for the design of the diode laser structure after the highly efficient production of near-bandgap radiation was demonstrated.

Research at Lincoln Laboratory leading up to the development of the injection laser in 1962

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rediker, R.H.

1987-06-01

In 1958 the Semiconductor Device Group at Lincoln Laboratory began to concentrate its efforts on exploiting GaAs. these efforts, in addition to yielding diodes which ns switching speeds, led to the development in early 1962 of diodes that emitted near-bandgap radiation with very high efficiency, and to the development in October 1962 of the diode laser. The theory of the semiconductor laser developed at Lincoln Laboratory in the mid-to-late 1950's provided the foundation necessary for the design of the diode laser structure after the highly efficient production of near-bandgap radiation was demonstrated.

40 CFR 63.320 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... (10 tons per year) of perchloroethylene to the atmosphere. In lieu of measuring a facility's potential...) per year. Consumption is determined according to § 63.323(d). (e) Each existing transfer machine... gallons) per year. Consumption is determined according to § 63.323(d). (f) If the total yearly...

40 CFR 63.320 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-07-01

... (10 tons per year) of perchloroethylene to the atmosphere. In lieu of measuring a facility's potential...) per year. Consumption is determined according to § 63.323(d). (e) Each existing transfer machine... gallons) per year. Consumption is determined according to § 63.323(d). (f) If the total yearly...

Vibration Test of a SNAP-8 Sodium-Potassium Alloy Pump

NASA Image and Video Library

1970-01-21

Aeronautics and Space Administration (NASA) Lewis Research Center. Aerojet General was contracted to design the SNAP-8 generator which employed a mercury Rankine system to convert the reactor’s heat into electrical power. The hermetically-sealed pump was designed to generate from 35 to 90 kilowatts of electrical power. In 1964 a SNAP-8 test rig with a mercury boiler and condenser was set up in cell W-1 of Lewis’ Engine Research Building to study the transients in the system’s three loops. In 1967 a complete Rankine system was operated for 60 days in W-1 to verify the integrity of the Lewis-developed mercury boiler. Further tests in 1969 verified the shutdown and startup of the system under normal and emergency conditions. Aerojet operated the first full-Rankine system in June 1966 and completed a 2500-hour endurance test in early 1969. Lewis and Aerojet’s success on the Rankine system was acknowledged with NASA Group Achievement Award in November 1970. The 1970 vibration tests, seen here, were conducted in Lewis’ Engine Research Building’s environmental laboratory. The testing replicated the shock and vibration expected to occur during the launch into space and subsequent maneuvering. The pump was analyzed on each of its major axes.

Mercury concentrations in snapping turtles (Chelydra serpentina) correlate with environmental and landscape characteristics.

PubMed

Turnquist, Madeline A; Driscoll, Charles T; Schulz, Kimberly L; Schlaepfer, Martin A

2011-10-01

Mercury (Hg) deposited onto the landscape can be transformed into methylmercury (MeHg), a neurotoxin that bioaccumulates up the aquatic food chain. Here, we report on Hg concentrations in snapping turtles (Chelydra serpentina) across New York State, USA. The objectives of this study were to: (1) test which landscape, water, and biometric characteristics correlate with total Hg (THg) concentrations in snapping turtles; and (2) determine whether soft tissue THg concentrations correlate with scute (shell) concentrations. Forty-eight turtles were sampled non-lethally from ten lakes and wetlands across New York to observe patterns under a range of ecosystem variables and water chemistry conditions. THg concentrations ranged from 0.041 to 1.50 μg/g and 0.47 to 7.43 μg/g wet weight of muscle tissue and shell, respectively. The vast majority of mercury (~94%) was in the MeHg form. Sixty-one percent of turtle muscle samples exceeded U.S. Environmental Protection Agency (U.S. EPA) consumption advisory limit of 0.3 μg Hg/g for fish. Muscle THg concentrations were significantly correlated with sulfate in water and the maximum elevation of the watershed. Shell THg concentrations were significantly correlated with the acid neutralizing capacity (ANC) of water, the maximum elevation of the watershed, the percent open water in the watershed, the lake to watershed size, and various forms of atmospheric Hg deposition. Thus, our results demonstrate that THg concentrations in snapping turtles are spatially variable, frequently exceed advisory limits, and are significantly correlated with several landscape and water characteristics.

SNAP-Ed (Supplemental Nutrition Assistance Program-Education) Increases Long-Term Food Security among Indiana Households with Children in a Randomized Controlled Study.

PubMed

Rivera, Rebecca L; Maulding, Melissa K; Abbott, Angela R; Craig, Bruce A; Eicher-Miller, Heather A

2016-11-01

Food insecurity is negatively associated with US children's dietary intake and health. The Supplemental Nutrition Assistance Program-Education (SNAP-Ed) aims to alleviate food insecurity by offering nutrition, budgeting, and healthy lifestyle education to low-income individuals and families. The objective of this study was to evaluate the long-term impact of the Indiana SNAP-Ed on food security among households with children. A randomized, controlled, parallel study design with SNAP-Ed as an intervention was carried out during a 4- to 10-wk intervention period. Intervention group participants received the first 4 Indiana SNAP-Ed curriculum lessons. Study participants (n = 575) were adults aged ≥18 y from low-income Indiana households with ≥1 child living in the household. Both treatment groups completed an assessment before and after the intervention period and 1 y after recruitment. The 18-item US Household Food Security Survey Module was used to classify the primary outcomes of food security for the household and adults and children in the household. A linear mixed model was used to compare intervention with control group effects over time on food security. Mean ± SEM changes in household food security score and food security score among household adults from baseline to 1-y follow-up were 1.2 ± 0.4 and 0.9 ± 0.3 units lower, respectively, in the intervention group than in the control group (P < 0.01). The mean change in food security score from baseline to 1-y follow-up among household children was not significantly different in the intervention group compared with the control group. SNAP-Ed improved food security over a longitudinal time frame among low-income Indiana households with children in this study. SNAP-Ed may be a successful intervention to improve food security. © 2016 American Society for Nutrition.

Development of a mercury electromagnetic centrifugal pump for the SNAP-8 refractory boiler development program

NASA Technical Reports Server (NTRS)

Fuller, R. A.; Schnacke, A. W.

1974-01-01

An electromagnetic pump, in which pressure is developed in mercury because of the interaction of the magnetic field and current which flows as a result of the voltage induced in the mercury contained in the pump duct, was developed for the SNAP-8 refractory boiler test facility. Pump performance results are presented for ten duct configurations and two stator sizes. These test results were used to design and fabricate a pump which met the SNAP-8 criteria of 530 psi developed pressure at 12,500 lb/hr. The pump operated continuously for over 13,000 hours without failure or performance degradation. Included in this report are descriptions of the experimental equipment, measurement techniques, all experimental data, and an analysis of the electrical losses in the pump.

Effects of environmental contaminants on snapping turtles of a tidal wetland

USGS Publications Warehouse

Albers, P.H.; Sileo, L.; Mulhern, B.M.

1986-01-01

Snapping turtles (Chelydra serpentina) were collected from a brackish-water and a nearly freshwater area in the contaminated Hackensack Meadowlands of New Jersey and an uncontaminated freshwater area in Maryland to determine the effects of environmental contaminants on a resident wetland species. No turtles were observed or caught in the Meadowlands at two trapping sites that were the most heavily contaminated by metals. Snapping turtles from the brackish-water area had an unusually low lipid content of body fat and reduced growth compared to turtles from the fresh-water areas in New Jersey and Maryland. Despite the serious metal contamination of the Hackensack Meadowlands, the metal content of kidneys and livers from New Jersey turtles was low and not greatly different from that of the Maryland turtles. Organochlorine pesticide concentrations in body fat were generally low at all three study areas. Polychlorinated biphenyls (PCBs) concentrations in fat were highest in male turtles from the New Jersey brackish-water area. Analysis of blood for amino-levulinic acid dehydratase, albumin, glucose, hemoglobin, osmolality, packed cell volume, total protein, triglycerides, and uric acid failed to reveal any differences among groups that would indicate physiological impairment related to contaminants.

The effects of stressful stimuli and hypothalamic-pituitary-adrenal axis activation are reversed by the melanin-concentrating hormone 1 receptor antagonist SNAP 94847 in rodents.

PubMed

Smith, Daniel G; Hegde, Laxminarayan G; Wolinsky, Toni D; Miller, Silke; Papp, Mariusz; Ping, Xiaoli; Edwards, Tanya; Gerald, Christophe P; Craig, Douglas A

2009-02-11

Melanin-concentrating hormone (MCH) is an orexigenic and dipsogenic neuropeptide that has been reported to mediate acute behavioral and neuroendocrine stress-related responses via MCH(1) receptor activation in rodents. The purpose of the present investigation was to use the MCH(1) receptor antagonist SNAP 94847 (N-(3-{1-[4-(3,4-difluoro-phenoxy)-benzyl]-piperidin-4-yl}-4-methyl-phenyl)-isobutyramide) to determine the effects of MCH(1) receptor blockade on MCH-evoked adrenocorticotropic hormone (ACTH) release, chronic mild stress-induced anhedonia, stress-induced hyperthermia and forced swim stress-induced immobility. The appropriate dose range for testing SNAP 94847 was determined by measuring MCH-evoked water drinking. The corresponding occupancy of MCH(1) receptors in rat striatum was also measured across a broad dose range. Orally administered (p.o.) SNAP 94847 (1-10 mg/kg) corresponds to 30-60% occupancy at MCH(1) receptors and significantly blocks water drinking induced by the intracerebroventricular (i.c.v.) injection of MCH. MCH (i.c.v.) significantly elevates plasma levels of ACTH in rats, and SNAP 94847 (2.5 mg/kg, p.o.) blocks MCH-evoked ACTH release. Using the chronic mild stress paradigm, we show that repeated daily exposure to environmental stressors for 5 weeks significantly suppresses sucrose intake in rats, and that SNAP 94847 (1 mg/kg, BID) for 1-5 weeks restores baseline sucrose intake. Moreover, a single administration of SNAP 94847 attenuates stress-induced hyperthermia and the behavioral effects of forced swim stress with minimal effective doses of 2.5 and 30 mg/kg (p.o.), respectively. The regulation of ACTH release and reversal of the effects of chronic and acute stress by SNAP 94847 are suggestive of a role for MCH(1) receptor blockade in the treatment of disorders characterized by high allostatic load.

Variation among edible podded snap bean accessions for pod and seed sugar content

USDA-ARS?s Scientific Manuscript database

Sugar content of immature snap bean (Phaseolus vulgaris) pods and the effects of sugars on other flavor compounds are important to consumers and affect their food and vegetable choices. The objective of this study was to identify variation within Phaseolus vulgaris in relation to sugars that affect ...

A dielectric elastomer actuator coupled with water: snap-through instability and giant deformation

NASA Astrophysics Data System (ADS)

Godaba, Hareesh; Foo, Choon Chiang; Zhang, Zhi Qian; Khoo, Boo Cheong; Zhu, Jian

2015-04-01

A dielectric elastomer actuator is one class of soft actuators which can deform in response to voltage. Dielectric elastomer actuators coupled with liquid have recently been developed as soft pumps, soft lenses, Braille displays, etc. In this paper, we conduct experiments to investigate the performance of a dielectric elastomer actuator which is coupled with water. The membrane is subject to a constant water pressure, which is found to significantly affect the electromechanical behaviour of the membrane. When the pressure is small, the membrane suffers electrical breakdown before snap-through instability, and achieves a small voltage-induced deformation. When the pressure is higher to make the membrane near the verge of the instability, the membrane can achieve a giant voltage-induced deformation, with an area strain of 1165%. When the pressure is large, the membrane suffers pressure-induced snap-through instability and may collapse due to a large amount of liquid enclosed by the membrane. Theoretical analyses are conducted to interpret these experimental observations.

Embryonic hypoxia programmes postprandial cardiovascular function in adult common snapping turtles (Chelydra serpentina).

PubMed

Wearing, Oliver H; Conner, Justin; Nelson, Derek; Crossley, Janna; Crossley, Dane A

2017-07-15

Reduced oxygen availability (hypoxia) is a potent stressor during embryonic development, altering the trajectory of trait maturation and organismal phenotype. We previously documented that chronic embryonic hypoxia has a lasting impact on the metabolic response to feeding in juvenile snapping turtles ( Chelydra serpentina ). Turtles exposed to hypoxia as embryos [10% O 2 (H10)] exhibited an earlier and increased peak postprandial oxygen consumption rate, compared with control turtles [21% O 2 (N21)]. In the current study, we measured central blood flow patterns to determine whether the elevated postprandial metabolic response in H10 turtles is linked to lasting impacts on convective transport. Five years after hatching, turtles were instrumented to quantify systemic ([Formula: see text]) and pulmonary ([Formula: see text]) blood flows and heart rate ( f H ) before and after a ∼5% body mass meal. In adult N21 and H10 turtles, f H was increased significantly by feeding. Although total stroke volume ( V S,tot ) remained at fasted values, this tachycardia contributed to an elevation in total cardiac output ([Formula: see text]). However, there was a postprandial reduction in a net left-right (L-R) shunt in N21 snapping turtles only. Relative to N21 turtles, H10 animals exhibited higher [Formula: see text] due to increased blood flow through the right systemic outflow vessels of the heart. This effect of hypoxic embryonic development, reducing a net L-R cardiac shunt, may support the increased postprandial metabolic rate we previously reported in H10 turtles, and is further demonstration of adult reptile cardiovascular physiology being programmed by embryonic hypoxia. © 2017. Published by The Company of Biologists Ltd.

Snapping turtles (Chelydra serpentina) as biomonitors of lead contamination of the Big River in Missouri`s Old Lead Belt

DOE Office of Scientific and Technical Information (OSTI.GOV)

Overmann, S.R.; Krajicek, J.J.

1995-04-01

The usefulness of common snapping turtles (Chelydra serpentina) as biomonitors of lead (Pb) contamination of aquatic ecosystems was assessed. Thirty-seven snapping turtles were collected from three sites on the Big River, an Ozarkian stream contaminated with Pb mine tailings. Morphometric measurements, tissue Pb concentrations (muscle, blood, bone, carapace, brain, and liver), {delta}-aminolevulinic acid dehydratase ({delta}-ALAD) activity, hematocrit, hemoglobin, plasma glucose, osmolality, and chloride ion content were measured. The data showed no effects of Pb contamination on capture success or morphological measurements. Tissue Pb concentrations were related to capture location. Hematocrit, plasma osmolality, plasma glucose, and plasma chloride ion content weremore » not significantly different with respect to capture location. The {delta}-ALAD activity levels were decreased in turtles taken from contaminated sites. Lead levels in the Big River do not appear to be adversely affecting the snapping turtles of the river. Chelydra serpentina is a useful species for biomonitoring of Pb-contaminated aquatic environments.« less

CIVIL RIGHTS U.S.A. PUBLIC SCHOOL--SOUTHERN STATES, 1962, KENTUCKY.

ERIC Educational Resources Information Center

KNOWLES, LAURENCE W.

DESEGREGATION OF KENTUCKY SCHOOLS BEGAN IN 1955 WITH A FEW SCATTERED DISTRICTS. THE MAJOR STEP CAME IN 1956, WHEN THE PUBLIC SCHOOLS OF LOUISVILLE WERE OPENED TO ALL CHILDREN WITHOUT REGARD TO RACE. SINCE 1956, THERE HAS BEEN STEADY, ALTHOUGH MEASURED, PROGRESS IN SCHOOL DESEGREGATION. IN 1962 ABOUT HALF OF KENTUCKY'S NEGRO STUDENTS ATTENDED…

Niobium tunnel junction fabrication using e-gun evaporation and SNAP

NASA Astrophysics Data System (ADS)

Kortlandt, J.; van der Zant, H. S. J.; Schellingerhout, A. J. G.; Mooij, J. E.

1990-11-01

We have fabricated high quality small area Nb-Al-Al 2O 3-Nb junctions with SNAP, making use of e-beam evaporation in a 10 -5 Pa diffusion pumped vacuum system. Nominal dimensions of the junctions are 8x8, 4x4 and 2x2 μm 2. We obtain typical current densities of 5-6 × 10 +2A/cm 2 and (critical current) x (subgap resistance) products of 40 mV.

Measurements and simulation of liquid films during drainage displacements and snap-off in constricted capillary tubes.

PubMed

Roman, Sophie; Abu-Al-Saud, Moataz O; Tokunaga, Tetsu; Wan, Jiamin; Kovscek, Anthony R; Tchelepi, Hamdi A

2017-12-01

When a wetting liquid is displaced by air in a capillary tube, a wetting film develops between the tube wall and the air that is responsible for the snap-off mechanism of the gas phase. By dissolving a dye in the wetting phase it is possible to relate a measure of the absorbance in the capillary to the thickness of liquid films. These data could be used to compare with cutting edge numerical simulations of the dynamics of snap-off for which experimental and numerical data are lacking. Drainage experiments in constricted capillary tubes were performed where a dyed wetting liquid is displaced by air for varying flow rates. We developed an optical method to measure liquid film thicknesses that range from 3 to 1000μm. The optical measures are validated by comparison with both theory and direct numerical simulations. In a constricted capillary tube we observed, both experimentally and numerically, a phenomenon of snap-off coalescence events in the vicinity of the constriction that bring new insights into our understanding and modeling of two-phase flows. In addition, the good agreement between experiments and numerical simulations gives confidence to use the numerical method for more complex geometries in the future. Copyright © 2017 Elsevier Inc. All rights reserved.

Insecticide Efficacy and Timing for Control of Western Bean Cutworm (Lepidoptera: Noctuidae) in Dry and Snap Beans.

PubMed

Goudis, L A; Trueman, C L; Baute, T S; Hallett, R H; Gillard, C L

2016-02-01

The western bean cutworm, Striacosta albicosta (Smith) (Lepidoptera: Noctuidae), is a recent pest of corn, dry,and snap beans, in the Great Lakes region, and best practices for its management in beans need to be established.Insecticide efficacy and application timing field studies, conducted in 2011–2013, determined that lambda-cyhalothrin and chlorantraniliprole were capable of reducing western bean cutworm feeding damage in dry beans from 2.3 to 0.4% in preharvest samples, and in snap beans from 4.8 to 0.1% of marketable pods, respectively. The best application timing in dry beans was determined to be 4–18 d after 50% egg hatch. No economic benefit was found when products were applied to dry beans, and despite high artificial inoculation rates, damage to marketable yield was relatively low. Thiamethoxam, methoxyfenozide, and spinetoram were also found to be effective at reducing western bean cutworm damage in dry bean to as low as 0.3% compared to an untreated control with 2.5% damaged pods. In snap beans, increased return on investment between CAD$400 and CAD$600 was seen with multiple applications of lambda-cyhalothrin, and with chlorantraniliprole applied 4 d after egg mass infestation.

Estimating E-Race European Corn Borer (Lepidoptera: Crambidae) Adult Activity in Snap Bean Fields Based on Corn Planting Intensity and Their Activity in Corn in New York Agroecosystems.

PubMed

Schmidt-Jeffris, Rebecca A; Huseth, Anders S; Nault, Brian A

2016-07-24

European corn borer, Ostrinia nubilalis (Hübner), is a major pest of processing snap bean because larvae are contaminants in pods. The incidence of O. nubilalis-contaminated beans has become uncommon in New York, possibly because widespread adoption of Bt field corn has suppressed populations. Snap bean fields located where Bt corn has been intensively grown in space and time may be at lower risk for O. nubilalis than fields located where Bt corn is not common. To manage O. nubilalis infestation risk, growers determine insecticide application frequency in snap bean based on pheromone-trapping information in nearby sweet corn fields; adult activity is presumed equivalent in both crops. Our goal was to determine if corn planting intensity and adult activity in sweet corn could be used to estimate O. nubilalis populations in snap bean in New York in 2014-2015. Numbers of O nubilalis adults captured in pheromone-baited traps located in snap bean fields where corn was and was not intensively grown were similar, suggesting that O. nubilalis does not respond to local levels of Bt corn in the landscape. Numbers of Ostrinia nubilalis captured in pheromone-baited traps placed by snap bean fields and proximal sweet corn fields were not related, indicating that snap bean growers should no longer make control decisions based on adult activity in sweet corn. Our results also suggest that the risk of O. nubilalis infestations in snap bean is low (∼80% of the traps caught zero moths) and insecticide applications targeting this pest should be reduced or eliminated. © The Authors 2016. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Amelogenesis Imperfecta, Facial Esthetics and Snap-On Smile.

PubMed

Wilson, Lee; Bradshaw, Jonathan P; Marks, Murray K

2015-01-01

Amelogenesis imperfecta is a hereditary enamel protein disorder affecting deciduous and secondary crown formation. The prevalence ranges from 1:700 to 1:14,000 depending on the population. These teeth may be hypoplastic, hypomineralized, or hypermineralized and are often discolored, sensitive and caries vulnerable. Patients often present with psychosocial issues due to appearance. Primary teeth are often treated with stainless steel crowns while secondary teeth are treated with full coverage esthetic crowns. The presenting preteen male here was fitted with Snap-On Smile? (www.snaponsmile.com). This treatment option provided cosmetic enhancement of the patient's appearance besides stabilization without altering the primary and secondary dentition during adolescent development.

SNAP 19 Pioneer F and G. Final Report

DOE R&D Accomplishments Database

1973-06-01

The generator developed for the Pioneer mission evolved from the SNAP 19 RTG`s launched aboard the NIMBUS III spacecraft. In order to satisfy the power requirements and environment of earth escape trajectory, significant modifications were made to the thermoelectric converter, heat source, and structural configuration. Specifically, a TAGS 2N thermoelectric couple was designed to provide higher efficiency and improved long term power performance, and the electrical circuitry was modified to yield very low magnetic field from current flow in the RTG. A new heat source was employed to satisfy operational requirements and its integration with the generator required alteration to the method of providing support to the fuel capsule.

Experimental Nonlinear Dynamics and Snap-Through of Post-Buckled Thin Laminated Composite Plates

NASA Astrophysics Data System (ADS)

Kim, Han-Gyu

Modern aerospace systems are increasingly being designed with composite panels and plates to achieve light weight and high specific strength and stiffness. For constrained panels, thermally-induced axial loading may cause buckling of the structure, which can lead to nonlinear and potentially chaotic behavior. When post-buckled composite plates experience snap-through, they are subjected to large-amplitude deformations and in-plane compressive loading. These phenomena pose a potential threat to the structural integrity of composite structures. In this work, the nonlinear dynamic behavior of post-buckled composite plates was investigated experimentally and computationally. For the experimental work, an electrodynamic shaker was used to apply harmonic loads and the dynamic response of plate specimens was measured using a single-point displacement-sensing laser, a double-point laser vibrometer (velocity-sensing), and a set of digital image correlation cameras. Both chaotic and periodic steady-state snap-through behaviors were investigated. The experimental data were used to characterize snap-through behaviors of the post-buckled specimens and their boundaries in the harmonic forcing parameter space. The nonlinear behavior of post-buckled plates was modeled using the classical laminated plate theory (CLPT) and the von Karman strain-displacement relations. The static equilibrium paths of the post-buckled plates were analyzed using an arc-length method with a branch-switching technique. For the dynamic analysis, the nonlinear equations of motion were derived based on CLPT and the nonlinear finite element model of the equations was constructed using the Hermite cubic interpolation functions for both conforming and nonconforming elements. The numerical analyses were conducted using the model and were compared with the experimental data.

A SURVEY OF INTENSIVE PROGRAMS IN THE UNCOMMON LANGUAGES, SUMMER 1962.

ERIC Educational Resources Information Center

HOENIGSWALD, HENRY M.; AND OTHERS

THIS REPORT ON INTENSIVE COURSES IN THE UNCOMMON LANGUAGES CONDUCTED AT 22 AMERICAN COLLEGES AND UNIVERSITIES DURING THE SUMMER OF 1962 IS THE RESULT OF A SURVEY UNDERTAKEN BY H.M. HOENIGSWALD OF THE UNIVERSITY OF PENNSYLVANIA, R.B. NOSS OF THE FOREIGN SERVICE INSTITUTE, AND E.N. MCCARUS AND J.K. YAMAGIWA OF THE UNIVERSITY OF MICHIGAN. (BY…

Snap-, CLIP- and Halo-Tag Labelling of Budding Yeast Cells

PubMed Central

Stagge, Franziska; Mitronova, Gyuzel Y.; Belov, Vladimir N.; Wurm, Christian A.; Jakobs, Stefan

2013-01-01

Fluorescence microscopy of the localization and the spatial and temporal dynamics of specifically labelled proteins is an indispensable tool in cell biology. Besides fluorescent proteins as tags, tag-mediated labelling utilizing self-labelling proteins as the SNAP-, CLIP-, or the Halo-tag are widely used, flexible labelling systems relying on exogenously supplied fluorophores. Unfortunately, labelling of live budding yeast cells proved to be challenging with these approaches because of the limited accessibility of the cell interior to the dyes. In this study we developed a fast and reliable electroporation-based labelling protocol for living budding yeast cells expressing SNAP-, CLIP-, or Halo-tagged fusion proteins. For the Halo-tag, we demonstrate that it is crucial to use the 6′-carboxy isomers and not the 5′-carboxy isomers of important dyes to ensure cell viability. We report on a simple rule for the analysis of 1H NMR spectra to discriminate between 6′- and 5′-carboxy isomers of fluorescein and rhodamine derivatives. We demonstrate the usability of the labelling protocol by imaging yeast cells with STED super-resolution microscopy and dual colour live cell microscopy. The large number of available fluorophores for these self-labelling proteins and the simplicity of the protocol described here expands the available toolbox for the model organism Saccharomyces cerevisiae. PMID:24205303

Operations NOUGAT and WHETSTONE Events: HARD HAT, DANNY BOY, MARSHMALLOW, MUDPACK, WISHBONE, GUMDROP, DILUTED WATERS, and TINY TOT, 15 February 1962-17 June 1965.

DTIC Science & Technology

1984-01-31

were conducted to study weapons effects from 15 February 1962 to 17 June 1965. ,Four were shaft-type, three were tunnel- type, and one was a crater...Of the 194 nuclear device tests conducted, 161 were for weapons development or effects purposes, and 33 were safety ex- periments. An additional 22...testing on 25 April 1962 until the last atmospheric test on 4 November 1962, 40 weapons development and weapons effects tests were conducted as part of the

Prevalence of obesity and diabetes in the socioeconomic transition of rural Mayas of Yucatan from 1962 to 2000.

PubMed

Loria, Alvar; Arroyo, Pedro; Fernandez, Victoria; Pardio, Jeanette; Laviada, Hugo

2018-02-20

The Mayas of the State of Yucatan in Mexico are the only aboriginal group with obesity and diabetes data before 1997. To analyze socioeconomic trends associated with the increase in obesity and diabetes seen in rural Yucatan from 1962 to 2000. Body weight, height and venous Fasting Blood Glucose (FBG) were measured in 263 rural Maya adults participating in a 2000 nutrition survey. Diabetes (FBG > 125 mg/dL) and obesity (BMI ≥ 30 kg/m 2 ) were 10.6% and 35.7%, respectively. These results contrast with those of a 1962 survey where diabetic prevalence was 2.3% and 0% in women and men respectively, with widespread adult pellagra and malnutrition. An important socioeconomic transition that took place in Yucatan during this lapse appeared to be associated to the obesity and diabetes increase. Rural Yucatan evolved from malnutrition conditions to high prevalence of obesity and diabetes in less than 40 years. This change was associated with the transition from an agroindustry-based economy, characterized by high-energy expenditure and low protein intake, to lower energy requirements of a Government-subsidized economy with larger food supply.

RETRAINING UNDER THE MANPOWER DEVELOPMENT AND TRAINING ACT OF 1962--INSTITUTIONAL PROGRAMS.

ERIC Educational Resources Information Center

HOOS, IDA R.

A DISCUSSION OF INSTITUTIONAL RETRAINING PROGRAMS UNDER THE MANPOWER DEVELOPMENT AND TRAINING ACT (1962) OUTLINES MANPOWER REPORTING AND TRAINING PROVISIONS OF THE ACT ITSELF, DISCUSSES PROBLEMS OF IMPLEMENTATION IN CALIFORNIA (I.E., DIFFICULTY IN FURNISHING ON-THE-JOB PROGRAMS AND PROPER COUNSELING), OUTLINES NATIONAL AND REGIONAL TRAINING UNDER…

SnAP reagents for the one-step synthesis of medium-ring saturated N-heterocycles from aldehydes

NASA Astrophysics Data System (ADS)

Vo, Cam-Van T.; Luescher, Michael U.; Bode, Jeffrey W.

2014-04-01

Interest in saturated N-heterocycles as scaffolds for the synthesis of bioactive molecules is increasing. Reliable and predictable synthetic methods for the preparation of these compounds, especially medium-sized rings, are limited. We describe the development of SnAP (Sn amino protocol) reagents for the transformation of aldehydes into seven-, eight- and nine-membered saturated N-heterocycles. This process occurs under mild, room-temperature conditions and offers exceptional substrate scope and functional-group tolerance. Air- and moisture-stable SnAP reagents are prepared on a multigram scale from inexpensive starting materials by simple reaction sequences. These new reagents and processes allow widely available aryl, heteroaryl and aliphatic aldehydes to be converted into diverse N-heterocycles, including diazepanes, oxazepanes, diazocanes, oxazocanes and hexahydrobenzoxazonines, by a single synthetic operation.

The Spiritual Needs Assessment for Patients (SNAP): development and validation of a comprehensive instrument to assess unmet spiritual needs.

PubMed

Sharma, Rashmi K; Astrow, Alan B; Texeira, Kenneth; Sulmasy, Daniel P

2012-07-01

Unmet spiritual needs have been associated with decreased patient ratings of quality of care, satisfaction, and quality of life. There is a need for a well-validated, psychometrically sound instrument to describe and measure spiritual needs. To develop a valid and reliable instrument to assess patients' spiritual needs. Instrument development was based on a literature review, clinical and pastoral evaluation, and cognitive pretesting (n=15 ambulatory cancer patients). Forty-seven ambulatory cancer patients completed cross-sectional and longitudinal surveys to test instrument validity and reliability. Internal reliability was assessed by Cronbach's α, test-retest reliability by Spearman's correlation coefficients, and construct validity by comparing instrument scores to a previously used single-item spiritual needs question. The Spiritual Needs Assessment for Patients (SNAP) comprises a total of 23 items in three domains: psychosocial (n=5), spiritual (n=13), and religious (n=5). Sixty percent of participants were white, 21% black, 13% Hispanic, and 6% Asian or other. Fifty-eight percent were Catholic, 13% Jewish, 11% Protestant, 2% Buddhist, 2% Muslim, and 2% Hindu. Sixty-eight percent described themselves as spiritual but not religious; 15% reported unmet spiritual needs; 19% wanted help meeting their spiritual needs. Cronbach's α for the total SNAP was 0.95, and for the subscales was psychosocial=0.74, spiritual=0.93, and religious needs=0.86. Test-retest correlation coefficients were total SNAP=0.69, psychosocial needs=0.51, spiritual needs=0.70, and religious needs=0.65. Participants reporting unmet spiritual needs had significantly higher mean scores on the total SNAP (66.3 vs. 49.4, P=0.03) and on the spiritual needs subscale (39.0 vs. 28.3, P=0.02). The results provide preliminary evidence that the SNAP is a valid and reliable instrument for measuring spiritual needs in a diverse patient population. Copyright © 2012 U.S. Cancer Pain Relief Committee

ApoE and SNAP-25 Polymorphisms Predict the Outcome of Multidimensional Stimulation Therapy Rehabilitation in Alzheimer's Disease.

PubMed

Guerini, Franca Rosa; Farina, Elisabetta; Costa, Andrea Saul; Baglio, Francesca; Saibene, Francesca Lea; Margaritella, Nicolò; Calabrese, Elena; Zanzottera, Milena; Bolognesi, Elisabetta; Nemni, Raffaello; Clerici, Mario

2016-10-01

Alzheimer's disease (AD) is a highly prevalent neurodegenerative disorder. Rate of decline and functional restoration in AD greatly depend on the capacity for neural plasticity within residual neural tissues; this is at least partially influenced by polymorphisms in genes that determine neural plasticity, including Apolipoprotein E4 (ApoE4) and synaptosomal-associated protein of 25 kDa (SNAP-25). We investigated whether correlations could be detected between polymorphisms of ApoE4 and SNAP-25 and the outcome of a multidimensional rehabilitative approach, based on cognitive stimulation, behavioral, and functional therapy (multidimensional stimulation therapy [MST]). Fifty-eight individuals with mild-to-moderate AD underwent MST for 10 weeks. Neuro-psychological functional and behavioral evaluations were performed blindly by a neuropsychologist at baseline and after 10 weeks of therapy using Mini-Mental State Examination (MMSE), Functional Living Skill Assessment (FLSA), and Neuropsychiatric Inventory (NPI) scales. Molecular genotyping of ApoE4 and SNAP-25 rs363050, rs363039, rs363043 was performed. Results were correlated with ΔMMSE, ΔNPI and ΔFLSA scores by multinomial logistic regression analysis. Polymorphisms in both genes correlated with the outcome of MST for MMSE and NPI scores. Thus, higher overall MMSE scores after rehabilitation were detected in ApoE4 negative compared to ApoE4 positive patients, whereas the SNAP-25 rs363050(G) and rs363039(A) alleles correlated with significant improvements in behavioural parameters. Polymorphisms in genes known to modulate neural plasticity might predict the outcome of a multistructured rehabilitation protocol in patients with AD. These data, although needing confirmation on larger case studies, could help optimizing the clinical management of individuals with AD, for example defining a more intensive treatment in those subjects with a lower likelihood of success. © The Author(s) 2016.

Contemporary Counterinsurgency (COIN) Insights from the French-Algerian War (1954-1962)

DTIC Science & Technology

2008-02-03

Council for Higher Education Accreditation. USAWC STRATEGY RESEARCH PROJECT CONTEMPORARY COUNTERINSURGENCY (COIN) INSIGHTS FROM THE FRENCH -ALGERIAN WAR...Colonel Kenneth M. DeTreux TITLE: Contemporary Counterinsurgency (COIN) Insights from the French - Algerian War (1954-1962) FORMAT: Strategy Research Project ...illustrative case study. This project researches and examines three main elements from the French Algerian experience: the Algerian insurgency, the French

The interplanetary and solar magnetic field sector structures, 1962 - 1968

NASA Technical Reports Server (NTRS)

Jones, D. E.

1972-01-01

The interplanetary magnetic field sector structure was observed from late 1962 through 1968. During this time it has been possible to study the manner in which the sector pattern and its relation to the photospheric magnetic field configuration changes from solar minimum to solar maximum. Observations were also made relating sector boundaries to specific regions on the solar disk. These and other observations related to the solar origin of the interplanetary field are briefly reviewed.

Design and methodology of SNAP-1: a Sprint National Anaesthesia Project to measure patient reported outcome after anaesthesia.

PubMed

Moonesinghe, Suneetha Ramani; Walker, Eleanor Mary Kate; Bell, Madeline

2015-01-01

Patient satisfaction is an important metric of health-care quality. Accidental awareness under general anaesthesia (AAGA) is a serious complication of anaesthesia care which may go unrecognised in the immediate perioperative period but leads to long-term psychological harm for affected patients. The SNAP-1 study aimed to measure patient satisfaction with anaesthesia care and the incidence of AAGA, reported on direct questioning within 24 h of surgery, in a large multicentre cohort. A secondary aim of SNAP-1 was to test the effectiveness of a new network of Quality Audit and Research Coordinators in NHS anaesthetic departments, to achieve widespread study participation and high patient recruitment rates. This manuscript describes the study methodology. SNAP-1 was a prospective observational cohort study. The study protocol was approved by the National Research Ethics Service. All UK NHS hospitals with anaesthetic departments were invited to participate. Adult patients undergoing any type of non-obstetric surgery were recruited in participating hospitals on 13th and 14th May 2014. Demographic data were collected by anaesthetists providing perioperative care. Patients were then approached within 24 h of surgery to complete two questionnaires-the Bauer patient satisfaction questionnaire (to measure patient reported outcome) and the modified Brice questionnaire (to detect possible accidental awareness). Completion of postoperative questionnaires was taken as evidence of implied consent. Results were recorded on a standard patient case report form, and local investigators entered anonymised data into an electronic database for later analysis by the core research team. Preliminary analyses indicate that over 15,000 patients were recruited across the UK, making SNAP-1 the largest NIHR portfolio-adopted study in anaesthesia to date. Both descriptive and analytic epidemiological analyses will be used to answer specific questions about the patient perception of anaesthesia

Oviductal morphology in relation to hormonal levels in the snapping turtle, Chelydra serpentina.

PubMed

Alkindi, A Y A; Mahmoud, I Y; Woller, M J; Plude, J L

2006-02-01

Microscopic and in situ visual observations were used to relate circulating hormone levels to morphological changes in the oviduct of the snapping turtle Chelydra serpentina throughout the ovarian cycle. Increase in levels of progesterone (P), estradiol (E2) and testosterone (T) levels coincide with an increase in number and growth of endometrial glands, luminal epithelial cells and secretory droplets throughout the oviduct. Testosterone and estradiol levels rose significantly (P < 0.05) after the May-June period and remained high throughout the rest of the summer. Progesterone levels remained stable throughout the summer, with a brief decline in July due to luteolysis. Hormonal values declined significantly (P < 0.001) at the end of the ovarian cycle in the fall. In situ visual observation of fresh oviducts at different stages of gravidity in recently ovulated turtles revealed that proteinaceous like components from the endometrial glands were released into the lumen to form fibers. The morphological features of the oviduct remained active throughout the summer months even though the snapping turtle is a monoclutch species which deposits all the eggs in late-May to mid-June. The high steroid levels correlate with and may be responsible for the secretory activity present throughout the summer and their decline correlates with change to low secretory activity in the fall. Calcium deposition accompanied by morphological changes in luminal cells are suggestive of secretory activity. In the egg-bearing turtles, uterine Ca2+ concentrations measured by flame atomic absorption spectrophotometry revealed significantly higher Ca2+ concentrations (P < 0.001) in eggs with soft shell than eggs without shell. There was a significant increase in calcium granules and proteinaceous fibers in luminal surface of the uterus during the period of eggshelling. This supports the fact that in the snapping turtle like in other reptiles, eggshelling process occurs in the uterus.

Rural Government--Poor Counties, 1962-87. Rural Development Research Report Number 88.

ERIC Educational Resources Information Center

Reeder, Richard J.; Jansen, Anicca C.

During the 1960s, many rural local governments were believed to provide inadequate government services, which hindered rural development. Rapid growth in government spending has reduced the incidence of government poverty from 78 percent of nonmetropolitan counties in 1962 to only 7 percent in 1987. Those counties still government-poor in 1987…

Numerical study of the effects of contact angle and viscosity ratio on the dynamics of snap-off through porous media

NASA Astrophysics Data System (ADS)

Starnoni, Michele; Pokrajac, Dubravka

2018-01-01

Snap-off is a pore-scale mechanism occurring in porous media in which a bubble of non-wetting phase displacing a wetting phase, and vice-versa, can break-up into ganglia when passing through a constriction. This mechanism is very important in foam generation processes, enhanced oil recovery techniques and capillary trapping of CO2 during its geological storage. In the present study, the effects of contact angle and viscosity ratio on the dynamics of snap-off are examined by simulating drainage in a single pore-throat constriction of variable cross-section, and for different pore-throat geometries. To model the flow, we developed a CFD code based on the Finite Volume method. The Volume-of-fluid method is used to track the interfaces. Results show that the threshold contact angle for snap-off, i.e. snap-off occurs only for contact angles smaller than the threshold, increases from a value of 28° for a circular cross-section to 30-34° for a square cross-section and up to 40° for a triangular one. For a throat of square cross-section, increasing the viscosity of the injected phase results in a drop in the threshold contact angle from a value of 30° when the viscosity ratio μ bar is equal to 1 to 26° when μ bar = 20 and down to 24° when μ bar = 20 .

An efficacy trial of brief lifestyle intervention delivered by generalist community nurses (CN SNAP trial).

PubMed

Laws, Rachel A; Chan, Bibiana C; Williams, Anna M; Davies, Gawaine Powell; Jayasinghe, Upali W; Fanaian, Mahnaz; Harris, Mark F

2010-02-23

Lifestyle risk factors, in particular smoking, nutrition, alcohol consumption and physical inactivity (SNAP) are the main behavioural risk factors for chronic disease. Primary health care (PHC) has been shown to be an effective setting to address lifestyle risk factors at the individual level. However much of the focus of research to date has been in general practice. Relatively little attention has been paid to the role of nurses working in the PHC setting. Community health nurses are well placed to provide lifestyle intervention as they often see clients in their own homes over an extended period of time, providing the opportunity to offer intervention and enhance motivation through repeated contacts. The overall aim of this study is to evaluate the impact of a brief lifestyle intervention delivered by community nurses in routine practice on changes in clients' SNAP risk factors. The trial uses a quasi-experimental design involving four generalist community nursing services in NSW Australia. Services have been randomly allocated to an 'early intervention' group or 'late intervention' (comparison) group. 'Early intervention' sites are provided with training and support for nurses in identifying and offering brief lifestyle intervention for clients during routine consultations. 'Late intervention site' provide usual care and will be offered the study intervention following the final data collection point. A total of 720 generalist community nursing clients will be recruited at the time of referral from participating sites. Data collection consists of 1) telephone surveys with clients at baseline, three months and six months to examine change in SNAP risk factors and readiness to change 2) nurse survey at baseline, six and 12 months to examine changes in nurse confidence, attitudes and practices in the assessment and management of SNAP risk factors 3) semi-structured interviews/focus with nurses, managers and clients in 'early intervention' sites to explore the

Non-isothermal elastoviscoplastic snap-through and creep buckling of shallow arches

NASA Technical Reports Server (NTRS)

Simitses, G. J.; Riff, R.

1987-01-01

The problem of buckling of shallow arches under transient thermomechanical loads is investigated. The analysis is based on nonlinear geometric and constitutive relations, and is expressed in a rate form. The material constitutive equations are capable of reproducing all non-isothermal, elasto-viscoplastic characteristics. The solution scheme is capable of predicting response which includes pre and postbuckling with creep and plastic effects. The solution procedure is demonstrated through several examples which include both creep and snap-through behavior.

Experimental heat transfer distribution on the SNAP 10A reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hopenfeld, J.; Toews, R.E.

1965-01-29

Heating distributions have been obtained for the SNAP 10A reactor by means of a thermal paint technique in the Rhodes and Bloxsom 60 in. hypersonic wind tunnel. Data and correlations are presented only for those reactor components where the ratio of the local heat transfer to that on the stagnation point of the calibration sphere was found to be independent of tunnel conditions. It is shown that these heating distributions can be applied directly to reentry conditions provided the thermally painted and the bare reactor surfaces are both catalytic to atom recombination.

Phenotypic plasticity in the common snapping turtle (Chelydra serpentina): long-term physiological effects of chronic hypoxia during embryonic development.

PubMed

Wearing, Oliver H; Eme, John; Rhen, Turk; Crossley, Dane A

2016-01-15

Studies of embryonic and hatchling reptiles have revealed marked plasticity in morphology, metabolism, and cardiovascular function following chronic hypoxic incubation. However, the long-term effects of chronic hypoxia have not yet been investigated in these animals. The aim of this study was to determine growth and postprandial O2 consumption (V̇o2), heart rate (fH), and mean arterial pressure (Pm, in kPa) of common snapping turtles (Chelydra serpentina) that were incubated as embryos in chronic hypoxia (10% O2, H10) or normoxia (21% O2, N21). We hypothesized that hypoxic development would modify posthatching body mass, metabolic rate, and cardiovascular physiology in juvenile snapping turtles. Yearling H10 turtles were significantly smaller than yearling N21 turtles, both of which were raised posthatching in normoxic, common garden conditions. Measurement of postprandial cardiovascular parameters and O2 consumption were conducted in size-matched three-year-old H10 and N21 turtles. Both before and 12 h after feeding, H10 turtles had a significantly lower fH compared with N21 turtles. In addition, V̇o2 was significantly elevated in H10 animals compared with N21 animals 12 h after feeding, and peak postprandial V̇o2 occurred earlier in H10 animals. Pm of three-year-old turtles was not affected by feeding or hypoxic embryonic incubation. Our findings demonstrate that physiological impacts of developmental hypoxia on embryonic reptiles continue into juvenile life. Copyright © 2016 the American Physiological Society.

Study of Crystal Formation and Nitric Oxide (NO) Release Mechanism from S-Nitroso-N-acetylpenicillamine (SNAP)-Doped CarboSil Polymer Composites for Potential Antimicrobial Applications.

PubMed

Wo, Yaqi; Li, Zi; Colletta, Alessandro; Wu, Jianfeng; Xi, Chuanwu; Matzger, Adam J; Brisbois, Elizabeth J; Bartlett, Robert H; Meyerhoff, Mark E

2017-07-15

Stable and long-term nitric oxide (NO) releasing polymeric materials have many potential biomedical applications. Herein, we report the real-time observation of the crystallization process of the NO donor, S -nitroso- N -acetylpenicillamine (SNAP), within a thermoplastic silicone-polycarbonate-urethane biomedical polymer, CarboSil 20 80A. It is demonstrated that the NO release rate from this composite material is directly correlated with the surface area that the CarboSil polymer film is exposed to when in contact with aqueous solution. The decomposition of SNAP in solution (e.g. PBS, ethanol, THF, etc.) is a pseudo-first-order reaction proportional to the SNAP concentration. Further, catheters fabricated with this novel NO releasing composite material are shown to exhibit significant effects on preventing biofilm formation on catheter surface by Pseudomonas aeruginosa and Proteus mirabilis grown in CDC bioreactor over 14 days, with a 2 and 3 log-unit reduction in number of live bacteria on their surfaces, respectively. Therefore, the SNAP-CarboSil composite is a promising new material to develop antimicrobial catheters, as well as other biomedical devices.

LCRE and SNAP 50-DR-1 programs. Engineering progress report, January 1, 1963--March 31, 1963

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Declassified 5 Sep 1973. Information is presented concerning LCRE specifications, primary coolant circuit, aaxiliary systems, fuel elements, instrumentation, materials development, and fabrication; and SNAP-50DR-1 specifications, fuel elements, pumps, steam generator, and materials development. (DCC)

SNAP: Automated Generation of High-Accuracy Interatomic Potentials using Quantum Data

NASA Astrophysics Data System (ADS)

Thompson, Aidan; Wood, Mitchell; Phillpot, Simon

Molecular dynamics simulation is a powerful computational method for bridging between macroscopic continuum models and quantum models treating a few hundred atoms, but it is limited by the accuracy of the interatomic potential. Sound physical and chemical understanding have led to good potentials for certain systems, but it is difficult to extend them to new materials and properties. The solution is obvious but challenging: develop more complex potentials that reproduce large quantum datasets. The growing availability of large data sets has made it possible to use automated machine-learning approaches for interatomic potential development. In the SNAP approach, the interatomic potential depends on a very general set of atomic neighborhood descriptors, based on the bispectrum components of the density projected onto the surface of the unit 3-sphere. Previously, this approach was demonstrated for tantalum, reproducing the screw dislocation Peierls barrier. In this talk, it will be shown that the SNAP method is capable of reproducing a wide range of energy landscapes relevant to diverse material science applications: i) point defects in indium phosphide, ii) stability of tungsten surfaces at high temperatures, and iii) formation of intrinsic defects in uranium. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corp., for the U.S. Dept. of Energys National Nuclear Security Admin. under contract DE-AC04-94AL85000.

"On the Possibilities of Climate Control" in 1962: Harry Wexler on Geoengineering and Ozone Destruction

NASA Astrophysics Data System (ADS)

Fleming, J. R.

2007-12-01

In 1962, in the early days of GCMs and satellites, Harry Wexler, Chief of the Scientific Services Division of the U.S. Weather Bureau and one of the most influential meteorologists of the 20th century, turned his attention to techniques that could raise or lower the overall temperature of the planet or rearrange its thermal structure. He also investigated possible inadvertent and purposeful damage to the ozone layer involving catalytic reactions of chorine and bromine. This work pre-dated the Nobel Prize-winning work on ozone depletion of P. Crutzen, M. Molina, and S. Rowland by about a decade. Wexler revealed his concerns about geoengineering and ozone destruction in a series of lectures "On the Possibilities of Climate Control" presented to technical audiences in Boston, Hartford, and Los Angeles in 1962. Using newly available results from GCMs and satellite heat budget experiments, Wexler pointed out that strategic manipulations of the Earth's shortwave and longwave radiation budgets could result in rather large-scale effects on general circulation patterns in short or longer periods, even approaching that of climatic change. These techniques, included increasing world temperature by several degrees by detonating up to ten H-bombs in the Arctic Ocean; decreasing world temperature by launching powder into an equatorial orbit to shade the Earth and make it look somewhat like Saturn and its rings; warming the lower atmosphere and cooling the stratosphere by artificial injections of water vapor or other substances; and notably, destroying all stratospheric ozone above the Arctic circle or near the equator using a relatively small amount of a catalytic agent such as chlorine or bromine. Wexler was preparing a new lecture in the summer of 1962 on "The Climate of Earth and Its Modifications," and might, under normal circumstances, have prepared his ideas for publication, as he had done earlier. However, he was cut down in his prime by a sudden heart attack on August 11

Surgical Treatment of Snapping Scapula Syndrome Due to Malunion of Rib Fractures.

PubMed

Ten Duis, Kaj; IJpma, Frank F A

2017-02-01

This report describes a case of snapping scapula syndrome (SSS) caused by malunited rib fractures. Abrasion of the deformed ribs was performed with good results. SSS as a cause of shoulder pain after thoracic trauma has to be considered and can be treated by a surgical abrasion technique. Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

Americans hear as well or better today compared with 40 years ago: hearing threshold levels in the unscreened adult population of the United States, 1959-1962 and 1999-2004.

PubMed

Hoffman, Howard J; Dobie, Robert A; Ko, Chia-Wen; Themann, Christa L; Murphy, William J

2010-12-01

(1) To present hearing threshold data from a recent nationally representative survey in the United States (National Health and Nutrition Examination Survey, 1999-2004) in a distributional format that might be appropriate to replace Annex B in international (ISO-1999) and national (ANSI S3.44) standards and (2) to compare these recent data with older survey data (National Health Examination Survey I, 1959-1962) on which the current Annex B is based. Better-ear threshold distributions (selected percentiles and their confidence intervals) were estimated using linear interpolation. The 95% confidence intervals for the medians for the two surveys were compared graphically for each of the four age groups and for both men and women. In addition, we calculated odds ratios comparing the prevalences of better-ear hearing impairment (thresholds > 25 dB HL) between the two surveys, for 500, 1000, 2000, and 4000 Hz, and for their four-frequency average. Across age and sex groups, median thresholds were lower (better) in the 1999-2004 survey at 500, 3000, 4000, and 6000 Hz (8000 Hz was not tested in the 1959-1962 survey). For both men and women, the prevalence of hearing impairment was significantly lower in 1999-2004 at 500, 2000, and 4000 Hz, but not at 1000 Hz. For men and women of a specific age, high-frequency hearing thresholds were lower (better) in 1999-2004 than in 1959-1962. The prevalences of hearing impairment were also lower in the recent survey. Differences seen at 500 Hz may be attributable at least in part to changes in standards for ambient noise in audiometry. The National Health and Nutrition Examination Survey 1999-2004 distributions are offered as a possible replacement for Annex B in ISO-1999 and ANSI S3.44.

Subacute casemix classification for stroke rehabilitation in Australia. How well does AN-SNAP v2 explain variance in outcomes?

PubMed

Kohler, Friedbert; Renton, Roger; Dickson, Hugh G; Estell, John; Connolly, Carol E

2011-02-01

We sought the best predictors for length of stay, discharge destination and functional improvement for inpatients undergoing rehabilitation following a stroke and compared these predictors against AN-SNAP v2. The Oxfordshire classification subgroup, sociodemographic data and functional data were collected for patients admitted between 1997 and 2007, with a diagnosis of recent stroke. The data were factor analysed using Principal Components Analysis for categorical data (CATPCA). Categorical regression analyses was performed to determine the best predictors of length of stay, discharge destination, and functional improvement. A total of 1154 patients were included in the study. Principal components analysis indicated that the data were effectively unidimensional, with length of stay being the most important component. Regression analysis demonstrated that the best predictor was the admission motor FIM score, explaining 38.9% of variance for length of stay, 37.4%.of variance for functional improvement and 16% of variance for discharge destination. The best explanatory variable in our inpatient rehabilitation service is the admission motor FIM. AN- SNAP v2 classification is a less effective explanatory variable. This needs to be taken into account when using AN-SNAP v2 classification for clinical or funding purposes.

Secretory proteins in the reproductive tract of the snapping turtle, Chelhydra serpentina.

PubMed

Mahmoud, I Y; Paulson, J R; Dudley, M; Patzlaff, J S; Al-Kindi, A Y A

2004-12-01

SDS-polyacrylamide gel electrophoresis was used to separate the secretory proteins produced by the epithelial and endometrial glands of the uterine tube and uterus in the snapping turtle Chelydra serpentina. The proteins were analyzed throughout the phases of the reproductive cycle from May to August, including preovulatory, ovulatory, postovulatory or luteal, and vitellogenic phases. The pattern of secretory proteins is quite uniform along the length of the uterine tube, and the same is true of the uterus, but the patterns for uterine tube and uterus are clearly different. We identify 13 major proteins in C. serpentina egg albumen. Bands co-migrating with 11 of these are found in the uterine tube, but at most 4 are found in the uterus, suggesting that the majority of the albumen proteins are most likely secreted in the uterine tube, not in the uterus. Although some of the egg albumen proteins are present in the uterine tube only at the time of ovulation, most of the bands corresponding to albumen proteins are present throughout the breeding season even though the snapping turtle is a monoclutch species. These results suggest that the glandular secretory phase in the uterine tube is active and quite homogeneous in function regardless of location or phase of the reproductive cycle.

Reproductive skew drives patterns of sexual dimorphism in sponge-dwelling snapping shrimps

PubMed Central

Chak, Solomon Tin Chi; Duffy, J. Emmett; Rubenstein, Dustin R.

2015-01-01

Sexual dimorphism is typically a result of strong sexual selection on male traits used in male–male competition and subsequent female choice. However, in social species where reproduction is monopolized by one or a few individuals in a group, selection on secondary sexual characteristics may be strong in both sexes. Indeed, sexual dimorphism is reduced in many cooperatively breeding vertebrates and eusocial insects with totipotent workers, presumably because of increased selection on female traits. Here, we examined the relationship between sexual dimorphism and sociality in eight species of Synalpheus snapping shrimps that vary in social structure and degree of reproductive skew. In species where reproduction was shared more equitably, most members of both sexes were physiologically capable of breeding. However, in species where reproduction was monopolized by a single individual, a large proportion of females—but not males—were reproductively inactive, suggesting stronger reproductive suppression and conflict among females. Moreover, as skew increased across species, proportional size of the major chela—the primary antagonistic weapon in snapping shrimps—increased among females and sexual dimorphism in major chela size declined. Thus, as reproductive skew increases among Synalpheus, female–female competition over reproduction appears to increase, resulting in decreased sexual dimorphism in weapon size. PMID:26041357

Neighbourhood and consumer food environment is associated with dietary intake among Supplemental Nutrition Assistance Program (SNAP) participants in Fayette County, Kentucky.

PubMed

Gustafson, Alison; Lewis, Sarah; Perkins, Sarah; Wilson, Corey; Buckner, Elizabeth; Vail, Ann

2013-07-01

The aim of the study was to determine the association between dietary outcomes and the neighbourhood food environment (street network distance from home to stores) and consumer food environment (Nutrition Environment Measurement Survey-Stores (NEMS-S) audit). The neighbourhood food environment was captured by creating 0?5-mile and 1-mile network distance (street distance) around each participant’s home and the nearest food venue (convenience store, grocery store, supermarket, farmers’ market and produce stand). The consumer food environment was captured by conducting NEMS-S in all grocery stores/supermarkets within 0?5 and 1 mile of participants’ homes. Fayette County, KY, USA. Supplemental Nutrition Assessment Program (SNAP) participants, n 147. SNAP participants who lived within 0?5 mile of at least one farmers’ market/produce stand had higher odds of consuming one serving or more of vegetables (OR56?92; 95% CI 4?09, 11?69), five servings or more of grains (OR51?76; 95% CI 1?01, 3?05) and one serving or more of milk (OR53?79; 95% CI 2?14, 6?71) on a daily basis. SNAP participants who lived within 0?5 mile of stores receiving a high score on the NEMS-S audit reported higher odds of consuming at least one serving of vegetables daily (OR53?07; 95% CI 1?78, 5?31). Taken together, both the neighbourhood food environment and the consumer food environment are associated with a healthy dietary intake among SNAP participants.

Design of a 25-kWe Surface Reactor System Based on SNAP Reactor Technologies

NASA Astrophysics Data System (ADS)

Dixon, David D.; Hiatt, Matthew T.; Poston, David I.; Kapernick, Richard J.

2006-01-01

A Hastelloy-X clad, sodium-potassium (NaK-78) cooled, moderated spectrum reactor using uranium zirconium hydride (UZrH) fuel based on the SNAP program reactors is a promising design for use in surface power systems. This paper presents a 98 kWth reactor for a power system the uses multiple Stirling engines to produce 25 kWe-net for 5 years. The design utilizes a pin type geometry containing UZrHx fuel clad with Hastelloy-X and NaK-78 flowing around the pins as coolant. A compelling feature of this design is its use of 49.9% enriched U, allowing it to be classified as a category III-D attractiveness and reducing facility costs relative to highly-enriched space reactor concepts. Presented below are both the design and an analysis of this reactor's criticality under various safety and operations scenarios.

Surface water records of New Mexico, water year 1962

USGS Publications Warehouse

,

1963-01-01

year intervals. These 5-year water-supply papers will show daily discharge and will be compiled on the same geographical areas previously used for the annual series; however, some of the 14 parts of conterminous United States will be further subdivided.

Temperature effects on snapping performance in the common snapper Chelydra serpentina (Reptilia, Testudines).

PubMed

Vervust, Bart; Brecko, Jonathan; Herrel, Anthony

2011-01-01

Studies on the effect of temperature on whole-animal performance traits other than locomotion are rare. Here we investigate the effects of temperature on the performance of the turtle feeding apparatus in a defensive context. We measured bite force and the kinematics of snapping in the Common Snapping Turtle (Chelydra serpentina) over a wide range of body temperatures. Bite force performance was thermally insensitive over the broad range of temperatures typically experienced by these turtles in nature. In contrast, neck extension (velocity, acceleration, and deceleration) and jaw movements (velocity, acceleration, and deceleration) showed clear temperature dependence with peak acceleration and deceleration capacity increasing with increasing temperatures. Our results regarding the temperature dependence of defensive behavior are reflected by the ecology and overall behavior of this species. These data illustrate the necessity for carefully controlling T(b) when carrying out behavioral and functional studies on turtles as temperature affects the velocity, acceleration, and deceleration of jaw and neck extension movements. More generally, these data add to the limited but increasing number of studies showing that temperature may have important effects on feeding and defensive performance in ectotherms. © 2010 Wiley-Liss, Inc.

Building the Case for SNAP: Creation of Multi-Band, Simulated Images With Shapelets

NASA Technical Reports Server (NTRS)

Ferry, Matthew A.

2005-01-01

Dark energy has simultaneously been the most elusive and most important phenomenon in the shaping of the universe. A case for a proposed space-telescope called SNAP (SuperNova Acceleration Probe) is being built, a crucial component of which is image simulations. One method for this is "Shapelets," developed at Caltech. Shapelets form an orthonormal basis and are uniquely able to represent realistic space images and create new images based on real ones. Previously, simulations were created using the Hubble Deep Field (HDF) as a basis Set in one band. In this project, image simulations are created.using the 4 bands of the Hubble Ultra Deep Field (UDF) as a basis set. This provides a better basis for simulations because (1) the survey is deeper, (2) they have a higher resolution, and (3) this is a step closer to simulating the 9 bands of SNAP. Image simulations are achieved by detecting sources in the UDF, decomposing them into shapelets, tweaking their parameters in realistic ways, and recomposing them into new images. Morphological tests were also run to verify the realism of the simulations. They have a wide variety of uses, including the ability to create weak gravitational lensing simulations.

Geological Survey research 1962: Short papers in geology, hydrology, and topography: Articles 180-239

USGS Publications Warehouse

,

1963-01-01

This collection of 60 short papers on subjects in the fields of geology, hydrology, topography, and related sciences is the last of a series released as chapters of Professional Paper 450. The papers in this chapter report on the scientific and economic results of current work by members of the Conservation, Geologic, Topographic, and Water Resources Divisions of the United States Geological Survey. Some of the papers announce new discoveries or present observations on problems of limited scope; other papers draw conclusions from more extensive or continuing investigations that in large part will be discussed in greater detail in reports to be published in the future.Chapter A of this series presents a synopsis of results from a wide range of work done during the 1962 fiscal year.

Elastoviscoplastic snap-through behavior of shallow arches subjected to thermomechanical loads

NASA Technical Reports Server (NTRS)

Simitses, George J.; Song, Yuzhao; Sheinman, Izhak

1991-01-01

The problem of snap-through buckling of clamped shallow arches under thermomechanical loads is investigated. The analysis is based on nonlinear kinematic relations and nonlinear rate-dependent unified constitutive equations. A finite element approach is employed to predict the, in general, inelastic buckling behavior. The construction material is alloy B1900 + Hf, which is commonly utilized in high-temperature environments. The effect of several parameters is assessed. These parameters include the rise parameter and temperature. Comparison between elastic and elastoviscoplastic responses is also presented.

Improved hemocompatibility of silicone rubber extracorporeal tubing via solvent swelling-impregnation of S-nitroso-N-acetylpenicillamine (SNAP) and evaluation in rabbit thrombogenicity model.

PubMed

Brisbois, Elizabeth J; Major, Terry C; Goudie, Marcus J; Bartlett, Robert H; Meyerhoff, Mark E; Handa, Hitesh

2016-06-01

Blood-contacting devices, including extracorporeal circulation (ECC) circuits, can suffer from complications due to platelet activation and thrombus formation. Development of nitric oxide (NO) releasing polymers is one method to improve hemocompatibility, taking advantage of the ability of low levels of NO to prevent platelet activation/adhesion. In this study a novel solvent swelling method is used to load the walls of silicone rubber tubing with the NO donor S-nitroso-N-acetylpenicillamine (SNAP). This SNAP-silicone rubber tubing exhibits an NO flux of ca. 1×10(-10)molcm(-2)min(-1), which mimics the range of NO release from the normal endothelium, which is stable for at least 4h. Images of the tubing before and after swelling, obtained via scanning electron microscopy, demonstrate that this swelling method has little effect on the surface properties of the tubing. The SNAP-loaded silicone rubber and silicone rubber control tubing are used to fabricate ECC circuits that are evaluated in a rabbit model of thrombogenicity. After 4h of blood flow, the SNAP-loaded silicone rubber circuits were able to preserve the blood platelet count at 64% of baseline (vs. 12% for silicone rubber control). A 67% reduction in the degree of thrombus formation within the thrombogenicity chamber was also observed. This study demonstrates the ability to improve the hemocompatibility of existing/commercial silicone rubber tubing via a simple solvent swelling-impregnation technique, which may also be applicable to other silicone-based blood-contacting devices. Localized nitric oxide (NO) release can be achieved from biomedical grade polymers doped with S-nitroso-N-acetylpenicillamine (SNAP). Despite the promising in vitro and in vivo biocompatibility results reported for these NO releasing polymers, many of these materials may face challenges in being translated to clinical applications, especially in the areas of polymer processing and manufacturing. In this study, we report a solvent

Redescription of Thalassodes antithetica Herbulot, 1962, an endemic moth from Inner Seychelles (Lepidoptera: Geometridae: Geometrinae).

PubMed

Bolotov, Ivan N; Matyot, Pat; Bippus, Maik; Spitsyn, Vitaly M; Kolosova, Yulia S; Kondakov, Alexander V

2016-07-19

The Seychelles archipelago is characterized by an exceptionally high level of endemism in certain taxa, including at least 275 endemic species of Lepidoptera (Legrand 1966; Gerlach & Matyot 2006; De Prins & De Prins 2015). Despite the fact that endemics are the main objects of conservation efforts, information regarding endemic Seychelles Lepidoptera is very poor, because the majority of them are known from a single or a few specimens (Legrand 1966; Gerlach and Matyot 2006; Bolotov et al. 2014, 2015). The emerald moth specimens are lacking in extensive samples obtained by earlier collectors (Fletcher 1910; Scott 1910; Fryer 1912). Further, two emerald moth species in the genus Thalassodes Guenée, 1858 have been reported from Seychelles, i.e., the widespread T. quadraria Guenée, 1858 (Legrand 1966; Gerlach & Matyot 2006; De Prins & De Prins 2015) and the endemic T. antithetica Herbulot, 1962. The latter species is known from eight specimens, collected between 1959 and 1963 (Legrand 1966; Gerlach & Matyot 2006). Herbulot (1962) provided a very short description of this species without any illustration. The protologue consists of a description of some external characters, i.e., antennae, palpi and legs, as well as the pattern of markings, but the male and female genitalia are not described. As the main diagnostic features, Herbulot (1962) noted two specific characters in the male morphology, namely the hind tibia with a single pair of spurs and an exceptional development of the lateral processes (octavals) on the posterior margin of the eighth sternite.

Problems, Survival and Transformation: Religious Education in Scotland--A Historical Review, 1962-1992

ERIC Educational Resources Information Center

Matemba, Yonah Hisbon

2014-01-01

This paper is an examination of the history of Scottish religious education (RE). Focusing on 1962-1992, it distinguishes the temporal processes that unfolded during this period to identify the circumstances that led to a serious case of neglect of the subject, especially in the non-denominational sector. Next, it highlights the less emphasised…

PERFORMANCE TESTS OF SNAP 10A THERMOELECTRIC ELEMENTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bergdorf, C.G.

1961-08-30

Apparatus for the performanee testing of SNAP 10A thermoelectric elements was designed, constructed, and is now in operation. Elements may be tested for any desired length of tfme up to 1400 deg F and in a vacuum of 1 x 10/ sup -5/ of Hg. The equipment used for these tcsts may also be utilized for measuring Seebeck coefficient and resistance as a function of temperature. Element performance is derived from the data on voltages and temperatures. The performance variables which are reported in graphic form are as follows: loaded output voltage at any desired DELTA T; open circuit outputmore » voltage at any desired DELTA T; power output under optimum load conditions; current produced under matched load conditions; and internal resistance of the element. (auth)« less

Micro-Sugar-Snap and -Wire-Cut Cookie Baking with Trans- and Zero-Trans-Fat Shortenings

USDA-ARS?s Scientific Manuscript database

The effect of trans- and zero-trans-fat shortenings on cookie-baking performance was evaluated, using the two AACC micro-cookie-baking methods. Regardless of fat type, sugar-snap cookies made with a given flour were larger in diameter, smaller in height, and greater in weight loss during baking tha...

SOURCES OF INFORMATION ON ROCK PHYSICS. CURRENT LITERATURE, FEBRUARY 28, 1962

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burgin, L.

1962-02-28

A literature review on the field of rock physics, rock mechanics, wave propagation and other related subjects is presented. The 206 references, wtth abstracts, are included under the following categories: physical properties, rock deformation, loading, engineering applications, seismology, wave propagation, and instruments and methods. In each section the articles are arranged alphabetically according to author. The titles are from material which was made available at the Colorado School of Mines, Arthur Lakes Library during February 1962. (M.C.G.)

40 CFR 63.784 - Compliance dates.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 10 2011-07-01 2011-07-01 false Compliance dates. 63.784 Section 63... Emission Standards for Shipbuilding and Ship Repair (Surface Coating) § 63.784 Compliance dates. (a) Each owner or operator of an existing affected source shall comply within two years after the effective date...

The Market for Food in the Nation's Schools.

ERIC Educational Resources Information Center

Kriesberg, Martin

This report is based on a study made during the school year 1962-63. Comparison with a benchmark survey conducted five years earlier shows that during the intervening period the number of public school districts decreased by one-third, while pupil enrollment increased by about 10 percent. The number of lunches served in the National School Lunch…

IJS procedure for RELAP5 to TRACE input model conversion using SNAP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prosek, A.; Berar, O. A.

2012-07-01

The TRAC/RELAP Advanced Computational Engine (TRACE) advanced, best-estimate reactor systems code developed by the U.S. Nuclear Regulatory Commission comes with a graphical user interface called Symbolic Nuclear Analysis Package (SNAP). Much of efforts have been done in the past to develop the RELAP5 input decks. The purpose of this study is to demonstrate the Institut 'Josef Stefan' (IJS) conversion procedure from RELAP5 to TRACE input model of BETHSY facility. The IJS conversion procedure consists of eleven steps and is based on the use of SNAP. For calculations of the selected BETHSY 6.2TC test the RELAP5/MOD3.3 Patch 4 and TRACE V5.0more » Patch 1 were used. The selected BETHSY 6.2TC test was 15.24 cm equivalent diameter horizontal cold leg break in the reference pressurized water reactor without high pressure and low pressure safety injection. The application of the IJS procedure for conversion of BETHSY input model showed that it is important to perform the steps in proper sequence. The overall calculated results obtained with TRACE using the converted RELAP5 model were close to experimental data and comparable to RELAP5/MOD3.3 calculations. Therefore it can be concluded, that proposed IJS conversion procedure was successfully demonstrated on the BETHSY integral test facility input model. (authors)« less

SNARE proteins synaptobrevin, SNAP-25 and syntaxin are involved in rapid and slow endocytosis at synapses

PubMed Central

Xu, Jianhua; Luo, Fujun; Zhang, Zhen; Xue, Lei; Wu, Xinsheng; Chiang, Hsueh-Cheng; Shin, Wonchul; Wu, Ling-Gang

2013-01-01

Rapid endocytosis, which takes only a few seconds, is widely observed in secretory cells. Although it is more efficient in recycling vesicles than slow clathrin-mediated endocytosis, its underlying mechanism, thought to be clathrin-independent, is largely unclear. Here we reported that cleavage of three SNARE proteins essential for exocytosis, including synaptobrevin, SNAP-25 and syntaxin, inhibited rapid endocytosis at the calyx of Held nerve terminal, suggesting the involvement of three SNARE proteins in rapid endocytosis. These SNARE proteins were also involved in slow endocytosis. In addition, SNAP-25 and syntaxin facilitated vesicle mobilization to the readily releasable pool, likely via their roles in endocytosis and/or exocytosis. We concluded that both rapid and slow endocytosis share the involvement of SNARE proteins. The dual role of three SNARE proteins in exo- and endocytosis suggests that SNARE proteins may be molecular substrates contributing to the exo-endocytosis coupling, which maintains exocytosis in secretory cells. PMID:23643538

Critical Windows of Cardiovascular Susceptibility to Developmental Hypoxia in Common Snapping Turtle (Chelydra serpentina) Embryos.

PubMed

Tate, Kevin B; Kohl, Zachary F; Eme, John; Rhen, Turk; Crossley, Dane A

2015-01-01

Environmental conditions fluctuate dramatically in some reptilian nests. However, critical windows of environmental sensitivity for cardiovascular development have not been identified. Continuous developmental hypoxia has been shown to alter cardiovascular form and function in embryonic snapping turtles (Chelydra serpentina), and we used this species to identify critical periods during which hypoxia modifies the cardiovascular phenotype. We hypothesized that incubation in 10% O2 during specific developmental periods would have differential effects on the cardiovascular system versus overall somatic growth. Two critical windows were identified with 10% O2 from 50% to 70% of incubation, resulting in relative heart enlargement, either via preservation of or preferential growth of this tissue, while exposure to 10% O2 from 20% to 70% of incubation resulted in a reduction in arterial pressure. The deleterious or advantageous aspects of these embryonic phenotypes in posthatching snapping turtles have yet to be explored. However, identification of these critical windows has provided insight into how the developmental environment alters the phenotype of reptiles and will also be pivotal in understanding its impact on the fitness of egg-laying reptiles.

Carbon dioxide (CO2) laser treatment of cutaneous papillomas in a common snapping turtle, Chelydra serpentina.

PubMed

Raiti, Paul

2008-06-01

Carbon dioxide (CO2) laser was used to treat multiple cutaneous papillomas on an adult female common snapping turtle, Chelydra serpentina serpentina. A combination of excisional and ablative techniques provided excellent intraoperative visibility and postoperative results due to the laser's unique ability to incise and vaporize soft tissue.

Which modifiable health risk behaviours are related? A systematic review of the clustering of Smoking, Nutrition, Alcohol and Physical activity ('SNAP') health risk factors.

PubMed

Noble, Natasha; Paul, Christine; Turon, Heidi; Oldmeadow, Christopher

2015-12-01

There is a growing body of literature examining the clustering of health risk behaviours, but little consensus about which risk factors can be expected to cluster for which sub groups of people. This systematic review aimed to examine the international literature on the clustering of smoking, poor nutrition, excess alcohol and physical inactivity (SNAP) health behaviours among adults, including associated socio-demographic variables. A literature search was conducted in May 2014. Studies examining at least two SNAP risk factors, and using a cluster or factor analysis technique, or comparing observed to expected prevalence of risk factor combinations, were included. Fifty-six relevant studies were identified. A majority of studies (81%) reported a 'healthy' cluster characterised by the absence of any SNAP risk factors. More than half of the studies reported a clustering of alcohol with smoking, and half reported clustering of all four SNAP risk factors. The methodological quality of included studies was generally weak to moderate. Males and those with greater social disadvantage showed riskier patterns of behaviours; younger age was less clearly associated with riskier behaviours. Clustering patterns reported here reinforce the need for health promotion interventions to target multiple behaviours, and for such efforts to be specifically designed and accessible for males and those who are socially disadvantaged. Copyright © 2015 Elsevier Inc. All rights reserved.

LCRE and SNAP 50-DR-1 programs. Engineering and progress report, April 1, 1963--June 30, 1963

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

BS>Declassified 6 Sep 1973. Information is presented concerning the LCRE kinetics, auxiliary systems, fuel, primary cooling system components, instrumentation, secondary cooling system, materials development, and fabrication; and SNAP-50/SPUR kinetics, fuel, primary system pump, steam generator, and materials development. (DCC)

The analysis of non-linear dynamic behavior (including snap-through) of postbuckled plates by simple analytical solution

NASA Technical Reports Server (NTRS)

Ng, C. F.

1988-01-01

Static postbuckling and nonlinear dynamic analysis of plates are usually accomplished by multimode analyses, although the methods are complicated and do not give straightforward understanding of the nonlinear behavior. Assuming single-mode transverse displacement, a simple formula is derived for the transverse load displacement relationship of a plate under in-plane compression. The formula is used to derive a simple analytical expression for the static postbuckling displacement and nonlinear dynamic responses of postbuckled plates under sinusoidal or random excitation. Regions with softening and hardening spring behavior are identified. Also, the highly nonlinear motion of snap-through and its effects on the overall dynamic response can be easily interpreted using the single-mode formula. Theoretical results are compared with experimental results obtained using a buckled aluminum panel, using discrete frequency and broadband point excitation. Some important effects of the snap-through motion on the dynamic response of the postbuckled plates are found.

Flood on Big Fossil Creek at Haltom City near Fort Worth, Texas, in 1962

USGS Publications Warehouse

Montgomery, John H.; Ruggles, Frederick H.; Patterson, James Lee

1965-01-01

The approximate area inundated near Fort Worth, Texas, by Big Fossil Creek, during the flood of September 7, 1962, is shown on a topographic map to record the flood hazard in graphic form. Big Fossil Creek, which drains an area of 74.7 square miles, flows generally southeastward along the northeast edge of Fort Worth through Richland Hills and Haltom City, into West Fork Trinity River. The flood of September 7, 1962, the greatest in Richland Hills since at least 1900 was the result of a high rate of discharge from the area upstream from the confluence of Big Fossil Creek and Whites Branch. Greater floods are possible, but no attempt has been made to show their probable overflow limits. Future protective works may reduce the frequency of flooding in the area but will not necessarily eliminate flooding. Changes in culture such as new highways and bridges and changes in land use may influence the inundation pattern of future floods. Mapping of the West Fork Trinity River flood was beyond the scope of the Big Fossil Creek study, and is not shown.

25 CFR 63.5-63.9 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false [Reserved] 63.5-63.9 Section 63.5-63.9 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR TRIBAL GOVERNMENT INDIAN CHILD PROTECTION AND FAMILY VIOLENCE PREVENTION Purpose, Policy, and Definitions §§ 63.5-63.9 [Reserved] ...

There is no capacity limited buffer in the Murdock (1962) free recall data

PubMed Central

2010-01-01

Theories of short term memory often include a limited capacity “buffer”. Such a buffer contains items which do not decay at all but are overwritten by new data. I show that one of the experiments that fueled the buffer concept, the free recall experiments by Murdock (J Exp Psychol 64(5):482–488, 1962), does not contain such a buffer. PMID:22132047

25 CFR 63.25-63.29 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false [Reserved] 63.25-63.29 Section 63.25-63.29 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR TRIBAL GOVERNMENT INDIAN CHILD PROTECTION AND FAMILY VIOLENCE PREVENTION Minimum Standards of Character and Suitability for Employment §§ 63.25-63.29 [Reserved] ...

25 CFR 63.37-63.50 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false [Reserved] 63.37-63.50 Section 63.37-63.50 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR TRIBAL GOVERNMENT INDIAN CHILD PROTECTION AND FAMILY VIOLENCE PREVENTION Indian Child Protection and Family Violence Prevention Program §§ 63.37-63.50 [Reserved] ...

Reproductive physiology in eastern snapping turtles (Chelydra serpentina) exposed to runoff from a concentrated animal feeding operation

EPA Science Inventory

The eastern snapping turtle (Chelydra serpentina) is widely distributed throughout the eastern and central U.S. and may be a useful model organism to study land use impacts on water quality. We compared the reproductive condition of C. serpentina from a pond impacted by runoff fr...

User’s guide to SNAP for ArcGIS® :ArcGIS interface for scheduling and network analysis program

Treesearch

Woodam Chung; Dennis Dykstra; Fred Bower; Stephen O’Brien; Richard Abt; John. and Sessions

2012-01-01

This document introduces a computer software named SNAP for ArcGIS® , which has been developed to streamline scheduling and transportation planning for timber harvest areas. Using modern optimization techniques, it can be used to spatially schedule timber harvest with consideration of harvesting costs, multiple products, alternative...

Snapping knee caused by the thickening of the medial hamstrings.

PubMed

de la Hera Cremades, B; Escribano Rueda, L; Lara Rubio, A

We report a case of symptomatic subluxation of the semitendinosus and gracilis over the medial condyle of the tibia caused by the thickening of its tendons. Snapping was reproduced on active extension. Clinical examination and, above all, dynamic ultrasound were the key for the diagnosis because other imaging tests were normal. Due to failure of conservative treatment with physiotherapy and infiltrations, surgery was undertaken, involving desinsertion and excision of distal 8cm segment of the semitendinosus and gracilis tendons. At the present time (6 months postoperatively), the patient is symptom-free and has returned to the previous normal life activities. Copyright © 2016 SECOT. Publicado por Elsevier España, S.L.U. All rights reserved.

Test pilots 1962 - Armstrong, Walker, Dana, Peterson, McKay, Thompson, Butchart

NASA Technical Reports Server (NTRS)

1962-01-01

The research pilots at what in 1962 was called the Flight Research Center standing in front of the X-1E. They are (left to right) Neil Armstrong, Joe Walker, Bill Dana, Bruce Peterson, Jack McKay, Milt Thompson, and Stan Butchart. of the group, Armstrong, Walker, Dana, McKay and Thompson all flew the X-15. Bruce Peterson flew the M2-F2 and HL-10 lifting bodies, while Stan Butchart was the B-29 drop plane pilot for many of the D-558-II and X-1 series research aircraft.

Snap-lock bags with red band: A study of manufacturing characteristics, thermal and chemical properties.

PubMed

Sim, Yvonne Hui Ying; Koh, Alaric C W; Lim, Shing Min; Yew, Sok Yee

2015-10-01

Drug packaging is commonly submitted to the Forensic Chemistry and Physics Laboratory of the Health Sciences Authority, Singapore, for examination. The drugs seized are often packaged in plastic bags. These bags are examined for linkages to provide law enforcement with useful associations between the traffickers and drug abusers. The plastic bags submitted may include snap-lock bags, some with a red band located above the snap-lock closure and some without. Current techniques for examination involve looking at the physical characteristics (dimensions, thickness and polarising patterns) and manufacturing marks of these bags. In cases where manufacturing marks on the main body of the bags are poor or absent, the manufacturing characteristics present on the red band can be examined. A study involving approximately 1000 bags was conducted to better understand the variations in the manufacturing characteristics of the red band. This understanding is crucial in helping to determine associations/eliminations between bags. Two instrumental techniques, namely differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FT-IR) were explored to evaluate the effectiveness of examining the chemical composition to discriminate the bags. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Renal transplantation: a twenty-five year experience.

PubMed Central

Murray, J E; Tilney, N L; Wilson, R E

1976-01-01

Boston has played a significant role in the development of renal transplantation. In Boston was performed the first successful isograft between identical twins (1954) the first successful allograft between fraternal twins (1959) and the first successful allograft from a cadaveric donor (1962). An immunosuppressive drug was also described in Boston by hematologists Schwartz and Dameschek (1959) and modified for renal transplantation in dogs (1961) and used for the first time in a human recipient in March 1962. By 1965 renal transplantation had become a clinical reality. Three hundred and ninety-eight of 589 recipients (68%) since 1950 are still alive, a remarkable figure considering that it includes all the earliest experimental transplants. One hundred and ninety-five of 295 (68%) with living-related donor transplants still have functioning allografts; 104/265 (39%) with cadaveric donor transplants have functioning grafts currently. Since 1968 transplants from living-related donors have an 80% one year survival whereas cadaveric donor transplants have approximately a 50% one year survival. Seventy-nine per cent of all one year survivors have had excellent psycho-social rehabilitation. PMID:791162

Irradiation qualification testing of SNAP-10A components

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chesavage, A. J.

1964-02-04

Selected SNAP 10A components were irradiated to about 10{sup14} nvt and 5{times} 10{sup 7} r at an average temperature of 136{degrees}F in a nominal vacuum of 2 {times} 10{sup {minus}5} torr. The components were operated periodically and the electrical characteristics recorded. Pre-irradiationand post-irradiation tests were conducted. Catastropic degradation occurred only in the low-level neutron detection system and about 1.5 {times} 10{sup 13} nvt and in the high-level neutron power supply at about 6{times} 10{sup 12} nvt. Marginal degradation occurred in the fusistors and in the silicone rubber insert material in connectors. The relays, low-voltage trip devices, expansion compensator position demodulator,more » resistance thermometer sensor and bridge, and the gamma detection system opearted within their respective specifications during and after irradiation. The insulation resistance of all components was adeqauate during and after irradiation.« less

Astronaut Walter Schirra leaves Hanger "S" prior to MA-8 flight

NASA Image and Video Library

1963-12-01

S63-00695 (3 Oct. 1962) --- Astronaut Walter M. Schirra Jr., pilot of the Mercury-Atlas 8 (MA-8) Earth-orbital spaceflight, leaves Hanger "S" at Cape Canaveral on his way to his scheduled Oct. 3, 1962 flight. Photo credit: NASA

A Prospective, Multicenter, Single-Blind Study Assessing Indices of SNAP II Versus BIS VISTA on Surgical Patients Undergoing General Anesthesia

PubMed Central

Bergese, Sergio D; Puente, Erika G; Marcus, R-Jay L; Krohn, Randall J; Docsa, Steven; Soto, Roy G; Candiotti, Keith A

2017-01-01

Background Traditionally, anesthesiologists have relied on nonspecific subjective and objective physical signs to assess patients’ comfort level and depth of anesthesia. Commercial development of electrical monitors, which use low- and high-frequency electroencephalogram (EEG) signals, have been developed to enhance the assessment of patients’ level of consciousness. Multiple studies have shown that monitoring patients’ consciousness levels can help in reducing drug consumption, anesthesia-related adverse events, and recovery time. This clinical study will provide information by simultaneously comparing the performance of the SNAP II (a single-channel EEG device) and the bispectral index (BIS) VISTA (a dual-channel EEG device) by assessing their efficacy in monitoring different anesthetic states in patients undergoing general anesthesia. Objective The primary objective of this study is to establish the range of index values for the SNAP II corresponding to each anesthetic state (preinduction, loss of response, maintenance, first purposeful response, and extubation). The secondary objectives will assess the range of index values for BIS VISTA corresponding to each anesthetic state compared to published BIS VISTA range information, and estimate the area under the curve, sensitivity, and specificity for both devices. Methods This is a multicenter, prospective, double-arm, parallel assignment, single-blind study involving patients undergoing elective surgery that requires general anesthesia. The study will include 40 patients and will be conducted at the following sites: The Ohio State University Medical Center (Columbus, OH); Northwestern University Prentice Women's Hospital (Chicago, IL); and University of Miami Jackson Memorial Hospital (Miami, FL). The study will assess the predictive value of SNAP II versus BIS VISTA indices at various anesthetic states in patients undergoing general anesthesia (preinduction, loss of response, maintenance, first purposeful

Neonatal mannequin comparison of the Upright self-inflating bag and snap-fit mask versus standard resuscitators and masks: leak, applied load and tidal volumes.

PubMed

Rafferty, Anthony Richard; Johnson, Lucy; Davis, Peter G; Dawson, Jennifer Anne; Thio, Marta; Owen, Louise S

2017-11-30

Neonatal mask ventilation is a difficult skill to acquire and maintain. Mask leak is common and can lead to ineffective ventilation. The aim of this study was to determine whether newly available neonatal self-inflating bags and masks could reduce mask leak without additional load being applied to the face. Forty operators delivered 1 min episodes of mask ventilation to a mannequin using the Laerdal Upright Resuscitator, a standard Laerdal infant resuscitator (Laerdal Medical) and a T-Piece Resuscitator (Neopuff), using both the Laerdal snap-fit face mask and the standard Laerdal size 0/1 face mask (equivalent sizes). Participants were asked to use pressure sufficient to achieve 'appropriate' chest rise. Leak, applied load, airway pressure and tidal volume were measured continuously. Participants were unaware that load was being recorded. There was no difference in mask leak between resuscitation devices. Leak was significantly lower when the snap-fit mask was used with all resuscitation devices, compared with the standard mask (14% vs 37% leak, P<0.01). The snap-fit mask was preferred by 83% of participants. The device-mask combinations had no significant effect on applied load. The Laerdal Upright Resuscitator resulted in similar leak to the other resuscitation devices studied, and did not exert additional load to the face and head. The snap-fit mask significantly reduced overall leak with all resuscitation devices and was the mask preferred by participants. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

The expression of a naturally occuriing truncated allele of an alpha-SNAP gene suppresses plant parasitic nematode infection

USDA-ARS?s Scientific Manuscript database

rhg1, defined within a 67 kb region of DNA on chromosome 18, is a major quantitative trait locus (QTL) in Glycine max (soybean) providing defense to the soybean cyst nematode (Heterodera glycines). Transcriptional mapping experiments identified an alpha soluble NSF attachment protein (alpha-SNAP) wi...

Factors contributing to unusually low runoff during the period 1962-68 in the Concho River Basin, Texas

USGS Publications Warehouse

Sauer, Stanley P.

1972-01-01

The analyses of rainfall-intensity and runoff data indicate that the basic cause for the relatively low runoff during the period 1962-68 was the lack of high-intensity, long-duration storms rather than any physical changes or agricultural practices in the watershed

A STUDY OF FARM MECHANICS JOBS TAUGHT BY TEACHERS OF VOCATIONAL AGRICULTURE IN MISSOURI.

ERIC Educational Resources Information Center

GEORGE, WILLIAM C.

IN ORDER TO DETERMINE WHAT FARM MECHANICS JOBS WERE BEING TAUGHT IN MISSOURI HIGH SCHOOL VOCATIONAL AGRICULTURE DAY CLASSES, 175 VOCATIONAL AGRICULTURE TEACHERS DURING THE 1962-63 SCHOOL YEAR RESPONDED TO A QUESTIONNAIRE WHICH INCLUDED 73 FARM MECHANICS JOBS IN 16 SUBJECT MATTER AREAS BASED ON A MISSOURI STATE DEPARTMENT OF EDUCATION LIST. THE…

New constraints shed light on strike-slip faulting beneath the southern Apennines (Italy): The 21 August 1962 Irpinia multiple earthquake

NASA Astrophysics Data System (ADS)

Vannoli, Paola; Bernardi, Fabrizio; Palombo, Barbara; Vannucci, Gianfranco; Console, Rodolfo; Ferrari, Graziano

2016-11-01

On 21 August 1962 an earthquake sequence set off near the city of Benevento, in Italy's southern Apennines. Three earthquakes, the largest having Mw 6.1, struck virtually the same area in less than 40 min (at 18:09, 18:19 and 18:44 UTC, respectively). Several historical earthquakes hit this region, and its seismic hazard is accordingly among the highest countrywide. Although poorly understood in the past, the seismotectonics of this region can be revealed by the 1962 sequence, being the only significant earthquake in the area for which modern seismograms are available. We determine location, magnitude, and nodal planes of the first event (18:09 UTC) of the sequence. The focal mechanism exhibits dominant strike-slip rupture along a north-dipping, E-W striking plane or along a west-dipping, N-S striking plane. Either of these solutions is significantly different from the kinematics of the typical large earthquakes occurring along the crest of the Southern Apennines, such as the 23 November 1980 Irpinia earthquake (Mw 6.9), caused by predominant normal faulting along NW-SE-striking planes. The epicentre of the 21 August 1962, 18:09 event is located immediately east of the chain axis, near one of the three north-dipping, E-W striking oblique-slip sources thought to have caused one of the three main events of the December 1456 sequence (Io XI MCS), the most destructive events in the southern Apennines known to date. We maintain that the 21 August 1962, 18:09 earthquake occurred along the E-W striking fault system responsible for the southernmost event of the 1456 sequence and for two smaller but instrumentally documented events that occurred on 6 May 1971 (Mw 5.0) and 27 September 2012 (Mw 4.6), further suggesting that normal faulting is not the dominant tectonic style in this portion of the Italian peninsula.

Subcellular localization of proteins in the anaerobic sulfate reducer Desulfovibrio vulgaris via SNAP-tag labeling and photoconversion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gorur, A.; Leung, C. M.; Jorgens, D.

2010-06-01

Systems Biology studies the temporal and spatial 3D distribution of macromolecular complexes with the aim that such knowledge will allow more accurate modeling of biological function and will allow mathematical prediction of cellular behavior. However, in order to accomplish accurate modeling precise knowledge of spatial 3D organization and distribution inside cells is necessary. And while a number of macromolecular complexes may be identified by its 3D structure and molecular characteristics alone, the overwhelming number of proteins will need to be localized using a reporter tag. GFP and its derivatives (XFPs) have been traditionally employed for subcelllar localization using photoconversion approaches,more » but this approach cannot be taken for obligate anaerobic bacteria, where the intolerance towards oxygen prevents XFP approaches. As part of the GTL-funded PCAP project (now ENIGMA) genetic tools have been developed for the anaerobe sulfate reducer Desulfovibrio vulgaris that allow the high-throughput generation of tagged-protein mutant strains, with a focus on the commercially available SNAP-tag cell system (New England Biolabs, Ipswich, MA), which is based on a modified O6-alkylguanine-DNA alkyltransferase (AGT) tag, that has a dead-end reaction with a modified O6-benzylguanine (BG) derivative and has been shown to function under anaerobic conditions. After initial challenges with respect to variability, robustness and specificity of the labeling signal we have optimized the labeling. Over the last year, as a result of the optimized labeling protocol, we now obtain robust labeling of 20 out of 31 SNAP strains. Labeling for 13 strains were confirmed at least five times. We have also successfully performed photoconversion on 5 of these 13 strains, with distinct labeling patterns for different strains. For example, DsrC robustly localizes to the periplasmic portion of the inner membrane, where as a DNA-binding protein localizes to the center of the cell

Swedish Progressive School Politics and the Disciplinary Regime of the School, 1946-1962: A Genealogical Perspective

ERIC Educational Resources Information Center

Qvarsebo, Jonas U. D.

2013-01-01

This article examines the vision of the Swedish comprehensive school reform between 1946-1962 as it pertains to the ever-troubling questions of discipline and order in school. Inspired primarily by the work of Michel Foucault and his genealogical perspective, the article problematises the notion that character formation and school discipline…

40 CFR 63.45-63.49 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 9 2010-07-01 2010-07-01 false [Reserved] 63.45-63.49 Section 63.45-63.49 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... Technology Determinations for Major Sources in Accordance With Clean Air Act Sections, Sections 112(g) and...

The Currie Report: Ten Years Later.

ERIC Educational Resources Information Center

Ewing, John L.

1972-01-01

The Currie Report, or the Report of the Commission on Education in New Zealand, which appeared in 1962, has been generating changes on a broad front within the New Zealand educational system throughout the last ten years. Eight areas of concern were identified by that Commission. The "most clamant" was the recruitment and training of…

KSC-LOC-63-5674

NASA Image and Video Library

1963-06-04

CAPE CANAVERAL, Fla. - Between 1962 and 1963, the Mission Control Center was modified to handle the additional complexities of the Gemini Program. In 1962, Pan American World Airways Inc. was contracted to design an addition to the facility, which wrapped around the east, north, and most of the west and south sides. The Mercury Mission Control Center in Florida played a key role in the United States' early spaceflight program. Located at Cape Canaveral Air Force Station, the original part of the building was constructed between 1956 and 1958, with additions in 1959 and 1963. The facility officially was transferred to NASA on Dec. 26, 1963, and served as mission control during all the Project Mercury missions, as well as the first three flights of the Gemini Program, when it was renamed Mission Control Center. With its operational days behind, on June 1, 1967, the Mission Control Center became a stop on the public tour of NASA facilities until the mid-90s. In 1999, much of the equipment and furnishings from the Flight Control Area were moved to the Kennedy Space Center Visitor Complex where they became part of the exhibit there. The building was demolished in spring 2010. Photo credit: NASA

KSC-LOC-63-1971

NASA Image and Video Library

1963-02-13

CAPE CANAVERAL, Fla. - Between 1962 and 1963, the Mission Control Center was modified to handle the additional complexities of the Gemini Program. In 1962, Pan American World Airways Inc. was contracted to design an addition to the facility, which wrapped around the east, north, and most of the west and south sides. The Mercury Mission Control Center in Florida played a key role in the United States' early spaceflight program. Located at Cape Canaveral Air Force Station, the original part of the building was constructed between 1956 and 1958, with additions in 1959 and 1963. The facility officially was transferred to NASA on Dec. 26, 1963, and served as mission control during all the Project Mercury missions, as well as the first three flights of the Gemini Program, when it was renamed Mission Control Center. With its operational days behind, on June 1, 1967, the Mission Control Center became a stop on the public tour of NASA facilities until the mid-90s. In 1999, much of the equipment and furnishings from the Flight Control Area were moved to the Kennedy Space Center Visitor Complex where they became part of the exhibit there. The building was demolished in spring 2010. Photo credit: NASA

KSC-LOC-63-1017

NASA Image and Video Library

1963-02-13

CAPE CANAVERAL, Fla. - Between 1962 and 1963, the Mission Control Center was modified to handle the additional complexities of the Gemini Program. In 1962, Pan American World Airways Inc. was contracted to design an addition to the facility, which wrapped around the east, north, and most of the west and south sides. The Mercury Mission Control Center in Florida played a key role in the United States' early spaceflight program. Located at Cape Canaveral Air Force Station, the original part of the building was constructed between 1956 and 1958, with additions in 1959 and 1963. The facility officially was transferred to NASA on Dec. 26, 1963, and served as mission control during all the Project Mercury missions, as well as the first three flights of the Gemini Program, when it was renamed Mission Control Center. With its operational days behind, on June 1, 1967, the Mission Control Center became a stop on the public tour of NASA facilities until the mid-90s. In 1999, much of the equipment and furnishings from the Flight Control Area were moved to the Kennedy Space Center Visitor Complex where they became part of the exhibit there. The building was demolished in spring 2010. Photo credit: NASA

KSC-LOC-63-5635

NASA Image and Video Library

1963-03-01

CAPE CANAVERAL, Fla. - Between 1962 and 1963, the Mission Control Center was modified to handle the additional complexities of the Gemini Program. In 1962, Pan American World Airways Inc. was contracted to design an addition to the facility, which wrapped around the east, north, and most of the west and south sides. The Mercury Mission Control Center in Florida played a key role in the United States' early spaceflight program. Located at Cape Canaveral Air Force Station, the original part of the building was constructed between 1956 and 1958, with additions in 1959 and 1963. The facility officially was transferred to NASA on Dec. 26, 1963, and served as mission control during all the Project Mercury missions, as well as the first three flights of the Gemini Program, when it was renamed Mission Control Center. With its operational days behind, on June 1, 1967, the Mission Control Center became a stop on the public tour of NASA facilities until the mid-90s. In 1999, much of the equipment and furnishings from the Flight Control Area were moved to the Kennedy Space Center Visitor Complex where they became part of the exhibit there. The building was demolished in spring 2010. Photo credit: NASA

Organochlorine pesticides, PCBs, dibenzodioxin, and furan concentrations in common snapping turtle eggs (Chelydra serpentina serpentina) in Akwesasne, Mohawk Territory, Ontario, Canada.

PubMed

de Solla, S R; Bishop, C A; Lickers, H; Jock, K

2001-04-01

Subsamples of eight clutches of common snapping turtle eggs (Chelydra serpentina serpentina) were collected from four sites from the territory of the Mohawk Nation, Akwesasne, on the shore of the St. Lawrence River. Egg contents were analyzed for organochlorine pesticides, polychlorinated biphenyls (PCBs), dibenzodioxins, and furans. The sites were 2 to 13 km downstream from PCB-contaminated landfill sites. Maximum concentrations of total PCBs in snapping turtle clutches were extremely high, and ranged from 2 378.2 ng/g to 737 683 ng/g (wet weight) and are among the highest recorded in any tissue of a free-ranging animal. Similarly, in a pooled sample of eggs from all four sites, the summed concentrations of non-ortho PCBs (n = 6 congeners) was also very high at 54.54 ng/g and the summed dioxin and furan concentrations (n = 11 congeners) was 85.8 ng/g. Sum organochlorine pesticide levels varied from 28 to 2,264 ng/g among the four sites. The levels of PCBs found in turtle eggs exceed concentrations associated with developmental problems and reduced hatching success in snapping turtles and other species and also exceed the Canadian tissue residue guidelines for toxic equivalency concentrations. The extremely high levels of organochlorine contaminants demonstrate the high degree of contamination in the environment in the Akwesasne area.

Development and Validation of Big Four Personality Scales for the Schedule for Nonadaptive and Adaptive Personality-2nd Edition (SNAP-2)

PubMed Central

Calabrese, William R.; Rudick, Monica M.; Simms, Leonard J.; Clark, Lee Anna

2012-01-01

Recently, integrative, hierarchical models of personality and personality disorder (PD)—such as the Big Three, Big Four and Big Five trait models—have gained support as a unifying dimensional framework for describing PD. However, no measures to date can simultaneously represent each of these potentially interesting levels of the personality hierarchy. To unify these measurement models psychometrically, we sought to develop Big Five trait scales within the Schedule for Adaptive and Nonadaptive Personality–2nd Edition (SNAP-2). Through structural and content analyses, we examined relations between the SNAP-2, Big Five Inventory (BFI), and NEO-Five Factor Inventory (NEO-FFI) ratings in a large data set (N = 8,690), including clinical, military, college, and community participants. Results yielded scales consistent with the Big Four model of personality (i.e., Neuroticism, Conscientiousness, Introversion, and Antagonism) and not the Big Five as there were insufficient items related to Openness. Resulting scale scores demonstrated strong internal consistency and temporal stability. Structural and external validity was supported by strong convergent and discriminant validity patterns between Big Four scale scores and other personality trait scores and expectable patterns of self-peer agreement. Descriptive statistics and community-based norms are provided. The SNAP-2 Big Four Scales enable researchers and clinicians to assess personality at multiple levels of the trait hierarchy and facilitate comparisons among competing “Big Trait” models. PMID:22250598

Development and validation of Big Four personality scales for the Schedule for Nonadaptive and Adaptive Personality--Second Edition (SNAP-2).

PubMed

Calabrese, William R; Rudick, Monica M; Simms, Leonard J; Clark, Lee Anna

2012-09-01

Recently, integrative, hierarchical models of personality and personality disorder (PD)--such as the Big Three, Big Four, and Big Five trait models--have gained support as a unifying dimensional framework for describing PD. However, no measures to date can simultaneously represent each of these potentially interesting levels of the personality hierarchy. To unify these measurement models psychometrically, we sought to develop Big Five trait scales within the Schedule for Nonadaptive and Adaptive Personality--Second Edition (SNAP-2). Through structural and content analyses, we examined relations between the SNAP-2, the Big Five Inventory (BFI), and the NEO Five-Factor Inventory (NEO-FFI) ratings in a large data set (N = 8,690), including clinical, military, college, and community participants. Results yielded scales consistent with the Big Four model of personality (i.e., Neuroticism, Conscientiousness, Introversion, and Antagonism) and not the Big Five, as there were insufficient items related to Openness. Resulting scale scores demonstrated strong internal consistency and temporal stability. Structural validity and external validity were supported by strong convergent and discriminant validity patterns between Big Four scale scores and other personality trait scores and expectable patterns of self-peer agreement. Descriptive statistics and community-based norms are provided. The SNAP-2 Big Four Scales enable researchers and clinicians to assess personality at multiple levels of the trait hierarchy and facilitate comparisons among competing big-trait models. PsycINFO Database Record (c) 2012 APA, all rights reserved.

Programmable snapping composites with bio-inspired architecture.

PubMed

Schmied, Jascha U; Le Ferrand, Hortense; Ermanni, Paolo; Studart, André R; Arrieta, Andres F

2017-03-13

The development of programmable self-shaping materials enables the onset of new and innovative functionalities in many application fields. Commonly, shape adaptation is achieved by exploiting diffusion-driven swelling or nano-scale phase transition, limiting the change of shape to slow motion predominantly determined by the environmental conditions and/or the materials specificity. To address these shortcomings, we report shape adaptable programmable shells that undergo morphing via a snap-through mechanism inspired by the Dionaea muscipula leaf, known as the Venus fly trap. The presented shells are composite materials made of epoxy reinforced by stiff anisotropic alumina micro-platelets oriented in specific directions. By tailoring the microstructure via magnetically-driven alignment of the platelets, we locally tune the pre-strain and stiffness anisotropy of the composite. This novel approach enables the fabrication of complex shapes showing non-orthotropic curvatures and stiffness gradients, radically extending the design space when compared to conventional long-fibre reinforced multi-stable composites. The rare combination of large stresses, short actuation times and complex shapes, results in hinge-free artificial shape adaptable systems with large design freedom for a variety of morphing applications.

High levels of maternally transferred mercury disrupt magnetic responses of snapping turtle hatchlings (Chelydra serpentina).

PubMed

Landler, Lukas; Painter, Michael S; Coe, Brittney Hopkins; Youmans, Paul W; Hopkins, William A; Phillips, John B

2017-09-01

The Earth's magnetic field is involved in spatial behaviours ranging from long-distance migration to non-goal directed behaviours, such as spontaneous magnetic alignment (SMA). Mercury is a harmful pollutant most often generated from anthropogenic sources that can bio-accumulate in animal tissue over a lifetime. We compared SMA of hatchling snapping turtles from mothers captured at reference (i.e., low mercury) and mercury contaminated sites. Reference turtles showed radio frequency-dependent SMA along the north-south axis, consistent with previous studies of SMA, while turtles with high levels of maternally inherited mercury failed to show consistent magnetic alignment. In contrast, there was no difference between reference and mercury exposed turtles on standard performance measures. The magnetic field plays an important role in animal orientation behaviour and may also help to integrate spatial information from a variety of sensory modalities. As a consequence, mercury may compromise the performance of turtles in a wide variety of spatial tasks. Future research is needed to determine the threshold for mercury effects on snapping turtles, whether mercury exposure compromises spatial behaviour of adult turtles, and whether mercury has a direct effect on the magnetoreception mechanism(s) that mediate SMA or a more general effect on the nervous system. Copyright © 2017 Elsevier Ltd. All rights reserved.

Effects of Management Practices on Meloidogyne incognita and Snap Bean Yield.

PubMed

Smittle, D A; Johnson, A W

1982-01-01

Phenamiphos applied at 6.7 kg ai/ha through a solid set or a center pivot irrigation system with 28 mm of water effectively controlled root-knot nematodes, Meloidogyne incognita, and resulted in greater snap bean growth and yields irrespective of growing season, tillage method, or cover crop system. The percentage yield increases attributed to this method of M. incognita control over nontreated controls were 45% in the spring crop, and 90% and 409% in the fall crops following winter rye and fallow, respectively. Root galling was not affected by tillage systems or cover crop, but disk tillage resulted in over 50% reduction in bean yield compared with yields from the subsoil-bed tillage system.

40 CFR 63.455 - Reporting requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) or a bleaching system specified in § 63.440(d)(3)(ii) shall submit, with the initial notification... modifications during the 2-year period. (c) The owner or operator of each bleaching system complying with § 63... that the daily application rates of chlorine and hypochlorite for that bleaching system have not...

Thermo-physics technical note No. 37: SNAP- 10A, Stainless Steel-316 vessel wall ablation. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Montgomery, L.D.

1964-12-07

The altitudes and times of ablation have been determined for the SNAP-10A, SS-316 vessel wall reentering under various conditions. The results are confined to one typical location on the reactor and to one typical reentry trajectory. The location is the side wall of the vessel and the trajectory is the one used in NAA-SR-8303.

Teaching Bitter Lessons: China’s Use of Force in Territorial Disputes 1962-1988

DTIC Science & Technology

2013-06-01

and risk mitigation efforts, followed by an overall analysis of Chinese behavior during the war. The Military Engagement...behave reasonably. In fact, China’s leader’s reasoning on strategic issues can be described as thoughtful, deliberative, and risk aware. Mao said...Chinese behavior during the Sino-Indo war of 1962 suggests the following: 1) China appeared to be risk averse in that it did not desire a conflict

Radioactivity: Recommendations of the International Commission on Radiological Units and Measurements (1962), (ICRU) Report 10 c.

ERIC Educational Resources Information Center

National Bureau of Standards (DOC), Washington, DC.

This handbook presents recommendations agreed upon at the meeting of the International Commission on Radiological Units and Measurements (ICRU) held in Montreux, Switzerland, in April 1962. It is written in a report form with a preface including symbols, abbreviations and definitions of terms used in the report. The report consists of four…

The reduced serum free triiodothyronine and increased dorsal hippocampal SNAP-25 and Munc18-1 had existed in middle-aged CD-1 mice with mild spatial cognitive impairment.

PubMed

Cao, Lei; Jiang, Wei; Wang, Fang; Yang, Qi-Gang; Wang, Chao; Chen, Yong-Ping; Chen, Gui-Hai

2013-12-02

Changes of synaptic proteins in highlighted brain regions and decreased serum thyroid hormones (THs) have been implied in age-related learning and memory decline. Previously, we showed significant pairwise correlations among markedly impaired spatial learning and memory ability, decreased serum free triiodothyronine (FT3) and increased hippocampal SNAP-25 and Munc18-1 in old Kunming mice. However, whether these changes and the correlations occur in middle-age mice remains unclear. Since this age is one of the best stages to study age-related cognitive decline, we explored the spatial learning and memory ability, serum THs, cerebral SNAP-25 and Munc18-1 levels and their relationships of middle-aged mice in this study. The learning and memory abilities of 35 CD-1 mice (19 mice aged 6 months and 16 mice aged 12 months) were measured with a radial six-arm water maze (RAWM). The SNAP-25 and Munc18-1 levels were semi-quantified by Western blotting and the serum THs were detected by radioimmunoassay. The results showed the middle-aged mice had decreased serum FT3, increased dorsal hippocampal (DH) SNAP-25 and Munc18-1, and many or long number of errors and latency in both learning and memory phases of the RAWM. The Pearson's correlation test showed that the DH SANP-25 and Munc18-1 levels were positively correlated with the number of errors and latency in learning phases of the RAWM. Meanwhile, the DH SANP-25 and Munc18-1 levels negatively correlated with the serum FT3 level. These results suggested that reduced FT3 with increased DH SNAP-25 and Munc18-1 levels might be involved in the spatial learning ability decline in the middle-aged mice. © 2013 Elsevier B.V. All rights reserved.

A Prospective, Multicenter, Single-Blind Study Assessing Indices of SNAP II Versus BIS VISTA on Surgical Patients Undergoing General Anesthesia.

PubMed

Bergese, Sergio D; Uribe, Alberto A; Puente, Erika G; Marcus, R-Jay L; Krohn, Randall J; Docsa, Steven; Soto, Roy G; Candiotti, Keith A

2017-02-03

Traditionally, anesthesiologists have relied on nonspecific subjective and objective physical signs to assess patients' comfort level and depth of anesthesia. Commercial development of electrical monitors, which use low- and high-frequency electroencephalogram (EEG) signals, have been developed to enhance the assessment of patients' level of consciousness. Multiple studies have shown that monitoring patients' consciousness levels can help in reducing drug consumption, anesthesia-related adverse events, and recovery time. This clinical study will provide information by simultaneously comparing the performance of the SNAP II (a single-channel EEG device) and the bispectral index (BIS) VISTA (a dual-channel EEG device) by assessing their efficacy in monitoring different anesthetic states in patients undergoing general anesthesia. The primary objective of this study is to establish the range of index values for the SNAP II corresponding to each anesthetic state (preinduction, loss of response, maintenance, first purposeful response, and extubation). The secondary objectives will assess the range of index values for BIS VISTA corresponding to each anesthetic state compared to published BIS VISTA range information, and estimate the area under the curve, sensitivity, and specificity for both devices. This is a multicenter, prospective, double-arm, parallel assignment, single-blind study involving patients undergoing elective surgery that requires general anesthesia. The study will include 40 patients and will be conducted at the following sites: The Ohio State University Medical Center (Columbus, OH); Northwestern University Prentice Women's Hospital (Chicago, IL); and University of Miami Jackson Memorial Hospital (Miami, FL). The study will assess the predictive value of SNAP II versus BIS VISTA indices at various anesthetic states in patients undergoing general anesthesia (preinduction, loss of response, maintenance, first purposeful response, and extubation). The SNAP

Differences between recalculated and original Dobson total ozone data from Hradec Kralove, Czechoslovakia, 1962-1990

NASA Technical Reports Server (NTRS)

Vanicek, Karel

1994-01-01

Backward reevaluation of long-term total ozone measurements from the Solar and Ozone Observatory of Czech Hydrometeorological Institute at Hradec Kralove, Czechoslovakia, was performed for the period 1962-1990. The homogenization was carried out with respect to the calibration level of the World Primary Standard Spectrophotometer No. 83 - WPSS by means of day-by-day recalculations of more than 25,000 individual measurements using the R-N tables reconstructed after international comparisons and regular standard lamp tests of the Dobson spectrophotometer No. 74. The results showed significant differences among the recalculated data and those original ones published in the bulletins Ozone Data for the World. In the period 1962-1979 they reached 10-19 D.U. (3.0-5.5%) for annual averages and even 26 D.U. (7.0%) for monthly averages of total ozone. Such differences exceed several times accuracy of measuring and can significantly influence character of trends of total ozone in Central Europe. Therefore the results from Hradec Kralove support the calls for reevaluation of all historical Dobson total ozone data sets at individual stations of Global Ozone Observing System.

Public Affairs: The Military and the Media, 1962-1968

DTIC Science & Technology

1988-01-01

Ne. "You’re up against a lot of women , children and old men ," Safer said to one marine; "how do you feel about it, corporal?" The soldier responded...24 22 "The Truth About a War Americans Aren’t Winning," U.S. News & World Report, 5 Aug 63, pp. 47-49. 23 David Halberstam, "Picture Is Cloudy in...been "mucking about in a serious way in Vietnam for several years," the Chicago Tribune charged that the country’s generals were "remittance men on

Two Disease-Causing SNAP-25B Mutations Selectively Impair SNARE C-terminal Assembly.

PubMed

Rebane, Aleksander A; Wang, Bigeng; Ma, Lu; Qu, Hong; Coleman, Jeff; Krishnakumar, Shyam; Rothman, James E; Zhang, Yongli

2018-02-16

Synaptic exocytosis relies on assembly of three soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) proteins into a parallel four-helix bundle to drive membrane fusion. SNARE assembly occurs by stepwise zippering of the vesicle-associated SNARE (v-SNARE) onto a binary SNARE complex on the target plasma membrane (t-SNARE). Zippering begins with slow N-terminal association followed by rapid C-terminal zippering, which serves as a power stroke to drive membrane fusion. SNARE mutations have been associated with numerous diseases, especially neurological disorders. It remains unclear how these mutations affect SNARE zippering, partly due to difficulties to quantify the energetics and kinetics of SNARE assembly. Here, we used single-molecule optical tweezers to measure the assembly energy and kinetics of SNARE complexes containing single mutations I67T/N in neuronal SNARE synaptosomal-associated protein of 25kDa (SNAP-25B), which disrupt neurotransmitter release and have been implicated in neurological disorders. We found that both mutations significantly reduced the energy of C-terminal zippering by ~10 k B T, but did not affect N-terminal assembly. In addition, we observed that both mutations lead to unfolding of the C-terminal region in the t-SNARE complex. Our findings suggest that both SNAP-25B mutations impair synaptic exocytosis by destabilizing SNARE assembly, rather than stabilizing SNARE assembly as previously proposed. Therefore, our measurements provide insights into the molecular mechanism of the disease caused by SNARE mutations. Copyright © 2017 Elsevier Ltd. All rights reserved.

Radionuclide observables for the Platte underground nuclear explosive test on 14 April 1962.

PubMed

Burnett, Jonathan L; Milbrath, Brian D

2016-11-01

Past nuclear weapon explosive tests provide invaluable information for understanding the radionuclide observables expected during an On-site Inspection (OSI) for the Comprehensive Nuclear-Test-Ban Treaty (CTBT). These radioactive signatures are complex and subject to spatial and temporal variability. The Platte underground nuclear explosive test on 14 April 1962 provides extensive environmental monitoring data that can be modelled and used to calculate the maximum time available for detection of the OSI-relevant radionuclides. The 1.6 kT test is especially useful as it released the highest amounts of recorded activity during Operation Nougat at the Nevada Test Site - now known as the Nevada National Security Site (NNSS). It has been estimated that 0.36% of the activity was released, and dispersed in a northerly direction. The deposition ranged from 1 × 10 -11 to 1 × 10 -9 of the atmospheric release (per m 2 ), and has been used in this paper to evaluate an OSI and the OSI-relevant radionuclides at 1 week to 2 years post-detonation. Radioactive decay reduces the activity of the OSI-relevant radionuclides by 99.7% within 2 years of detonation, such that detection throughout the hypothesized inspection is only achievable close to the explosion where deposition was highest. Copyright © 2016 Elsevier Ltd. All rights reserved.

40 CFR 63.854-63.859 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-07-01

....854-63.859 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Primary Aluminum Reduction Plants §§ 63.854-63...

40 CFR 63.854-63.859 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

....854-63.859 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Primary Aluminum Reduction Plants §§ 63.854-63...

40 CFR 63.854-63.859 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-07-01

....854-63.859 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Primary Aluminum Reduction Plants §§ 63.854-63...

40 CFR 63.854-63.859 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-07-01

....854-63.859 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Primary Aluminum Reduction Plants §§ 63.854-63...

VAMP-2, SNAP-25A/B and syntaxin-1 in glutamatergic and GABAergic synapses of the rat cerebellar cortex

PubMed Central

2011-01-01

Background The aim of this study was to assess the distribution of key SNARE proteins in glutamatergic and GABAergic synapses of the adult rat cerebellar cortex using light microscopy immunohistochemical techniques. Analysis was made of co-localizations of vGluT-1 and vGluT-2, vesicular transporters of glutamate and markers of glutamatergic synapses, or GAD, the GABA synthetic enzyme and marker of GABAergic synapses, with VAMP-2, SNAP-25A/B and syntaxin-1. Results The examined SNARE proteins were found to be diffusely expressed in glutamatergic synapses, whereas they were rarely observed in GABAergic synapses. However, among glutamatergic synapses, subpopulations which did not contain VAMP-2, SNAP-25A/B and syntaxin-1 were detected. They included virtually all the synapses established by terminals of climbing fibres (immunoreactive for vGluT-2) and some synapses established by terminals of parallel and mossy fibres (immunoreactive for vGluT-1, and for vGluT-1 and 2, respectively). The only GABA synapses expressing the SNARE proteins studied were the synapses established by axon terminals of basket neurons. Conclusion The present study supplies a detailed morphological description of VAMP-2, SNAP-25A/B and syntaxin-1 in the different types of glutamatergic and GABAergic synapses of the rat cerebellar cortex. The examined SNARE proteins characterize most of glutamatergic synapses and only one type of GABAergic synapses. In the subpopulations of glutamatergic and GABAergic synapses lacking the SNARE protein isoforms examined, alternative mechanisms for regulating trafficking of synaptic vesicles may be hypothesized, possibly mediated by different isoforms or homologous proteins. PMID:22094010

Dark Signal Characterization of 1.7 micron cutoff devices for SNAP

NASA Astrophysics Data System (ADS)

Smith, R. M.; SNAP Collaboration

2004-12-01

We report initial progress characterizing non-photometric sources of error -- dark current, noise, and zero point drift -- for 1.7 micron cutoff HgCdTe and InGaAs detectors under development by Raytheon, Rockwell, and Sensors Unlimited for SNAP. Dark current specifications can already be met with several detector types. Changes to the manufacturing process are being explored to improve the noise reduction available through multiple sampling. In some cases, a significant number of pixels suffer from popcorn noise, with a few percent of all pixels exhibiting a ten fold noise increase. A careful study of zero point drifts is also under way, since these errors can dominate dark current, and may contribute to the noise degradation seen in long exposures.

Characterization of microsatellite DNA markers for the alligator snapping turtle, Macrochelys temminckii: Primer note

USGS Publications Warehouse

Hackler, J.C.; Van Den Bussche, Ronald A.; Leslie, David M.

2007-01-01

Two trinucleotide and seven tetranucleotide microsatellite loci were isolated from an alligator snapping turtle Macrochelys temminckii. To assess the degree of variability in these nine microsatellite loci, we genotyped 174 individuals collected from eight river drainage basins in the southeastern USA. These markers revealed a moderate degree of allelic diversity (six to 16 alleles per locus) and observed heterozygosity (0.166-0.686). These polymorphic microsatellite loci provide powerful tools for population genetic studies for a species that is afforded some level of conservation protection in every state in which it occurs. ?? 2006 The Authors.

Change in the Green-Up Dates for Quercus mongolica in Northeast China and Its Climate-Driven Mechanism from 1962 to 2012.

PubMed

Fan, Deqin; Zhu, Wenquan; Zheng, Zhoutao; Zhang, Donghai; Pan, Yaozhong; Jiang, Nan; Zhou, Xiafei

2015-01-01

The currently available studies on the green-up date were mainly based on ground observations and/or satellite data, and few model simulations integrated with wide coverage satellite data have been reported at large scale over a long time period (i.e., > 30 years). In this study, we combined phenology mechanism model, long-term climate data and synoptic scale remote sensing data to investigate the change in the green-up dates for Quercus mongolica over 33 weather stations in Northeast China and its climate-driven mechanism during 1962-2012. The results indicated that the unified phenology model can be well parameterized with the satellite derived green-up dates. The optimal daily mean temperature for chilling effect was between -27°C and 1°C for Q. mongolica in Northeast China, while the optimal daily mean temperature for forcing effect was above -3°C. The green-up dates for Q. mongolica across Northeast China showed a delayed latitudinal gradient of 2.699 days degree-1, with the earliest date on the Julian day 93 (i.e., 3th April) in the south and the latest date on the Julian day 129 (i.e., 9th May) in the north. The green-up date for Q. mongolica in Northeast China has advanced 6.6 days (1.3 days decade-1) from 1962 to 2012. With the prevailing warming in autumn, winter and spring in Northeast China during the past 51 years, the chilling effect for Q. mongolica has been weakened, while the forcing effect has been enhanced. The advancing trend in the green-up dates for Q. mongolica implied that the enhanced forcing effect to accelerate green-up was stronger than the weakened chilling effect to hold back green-up while the changes of both effects were caused by the warming climate.

Radionuclide observables for the Platte underground nuclear explosive test on 14 April 1962

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burnett, Jonathan L.; Milbrath, Brian D.

2016-11-01

Past nuclear weapons tests provide invaluable information for understanding the radionuclide observables and data quality objectives expected during an On-site Inspection (OSI) for the Comprehensive Nuclear-Test-Ban Treaty (CTBT). These radioactive signatures are complex and subject to spatial and temporal variability. The Platte Underground Nuclear Test on 14 April 1962 provides extensive environmental monitoring data that can be modelled and used to assess an OSI. The 1.6 kT test is especially useful as it released the highest amounts of recorded activity during Operation Nougat at the Nevada Test Site – now known as the Nevada National Security Site (NNSS). It hasmore » been estimated that 0.36% of the activity was released, and dispersed in a northerly direction. The deposition ranged from 1 x 10-11 to 1 x 10-9 of the atmospheric release (per m2), and has been used to evaluate a hypothetical OSI at 1 week to 2 years post-detonation. Radioactive decay reduces the activity of the 17 OSI relevant radionuclides by 99.7%, such that detection throughout the inspection is only achievable close to the explosion where deposition was highest.« less

Four-year to Eight-year Results of Vagotomy and Simple Drainage for Benign Lesser Curve Gastric Ulcer

PubMed Central

Burge, H.; Gill, A. Morton; Maclean, C.; Stedeford, R.

1970-01-01

The results of vagotomy and simple drainage for recurrent benign lesser curve gastric ulcer are recorded. Seventy-two consecutive cases were treated from 1962 to 1965. The follow-up is therefore from five to eight years. In only two cases did the ulcer fail to heal and remain healed. Four years after operation both these had persistent ulceration and persistent gastric retention. Both have apparently been cured by gastrojejunostomy done to improve gastric drainage. ImagesFIG. 1FIG. 2FIG. 3 PMID:5451588

Mary Jane Hogue (1883-1962): A pioneer in human brain tissue culture.

PubMed

Zottoli, Steven J; Seyfarth, Ernst-August

2018-05-16

The ability to maintain human brain explants in tissue culture was a critical step in the use of these cells for the study of central nervous system disorders. Ross G. Harrison (1870-1959) was the first to successfully maintain frog medullary tissue in culture in 1907, but it took another 38 years before successful culture of human brain tissue was accomplished. One of the pioneers in this achievement was Mary Jane Hogue (1883-1962). Hogue was born into a Quaker family in 1883 in West Chester, Pennsylvania, and received her undergraduate degree from Goucher College in Baltimore, Maryland. Research with the developmental biologist Theodor Boveri (1862-1915) in Würzburg, Germany, resulted in her Ph.D. (1909). Hogue transitioned from studying protozoa to the culture of human brain tissue in the 1940s and 1950s, when she was one of the first to culture cells from human fetal, infant, and adult brain explants. We review Hogue's pioneering contributions to the study of human brain cells in culture, her putative identification of progenitor neuroblast and/or glioblast cells, and her use of the cultures to study the cytopathogenic effects of poliovirus. We also put Hogue's work in perspective by discussing how other women pioneers in tissue culture influenced Hogue and her research.

Chlorinated hydrocarbons in early life stages of the common snapping turtle (Chelydra serpentina serpentina) from a coastal wetland on Lake Ontario, Canada

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bishop, C.A.; Lean, D.R.S.; Carey, J.H.

1995-03-01

To assess intra-clutch variation in contaminant concentrations in eggs, and to investigate the dynamics of chlorinated hydrocarbon accumulation in embryos of the common snapping turtle (Chelydra serpentina), concentrations of p,p{prime}-DDE, hexachlorobenzene, trans-nonachlor, cis-chlordane, and six PCB congeners were measured in eggs, embryos, and hatchlings. Samples were collected from Cootes Paradise, a wetland at the western end of Lake Ontario, Ontario, Canada. The intra-clutch variation in chlorinated hydrocarbon concentrations within four snapping turtle clutches was determined by analyzing the first, last, and middle five eggs oviposited in the nest. The first five eggs had the highest mean concentrations of all chlorinatedmore » hydrocarbons, wet weight, and egg diameter. On a lipid weight basis, the first five eggs contained the highest concentration of all compounds except total PCBs and cis-chlordane. The concentration of cis-chlordane was the only parameter measured that was significantly different among the three sets of eggs. At hatching, snapping turtles without yolk sacs contained from 55.2 to 90.5% of the absolute amount of organochlorine compounds measured in the egg at oviposition. Eighteen days after hatching, the body burden of PCBs and pesticides decreased to 45.3 to 62.2% of that in the fresh egg. The accumulation of organochlorine chemicals in embryonic turtles peaked at or just before hatching and then declined thereafter, which is consistent with trends reported in developing sea turtles, fish, and birds.« less

Snap Your Fingers! An ERP/sLORETA Study Investigating Implicit Processing of Self- vs. Other-Related Movement Sounds Using the Passive Oddball Paradigm

PubMed Central

Justen, Christoph; Herbert, Cornelia

2016-01-01

So far, neurophysiological studies have investigated implicit and explicit self-related processing particularly for self-related stimuli such as the own face or name. The present study extends previous research to the implicit processing of self-related movement sounds and explores their spatio-temporal dynamics. Event-related potentials (ERPs) were assessed while participants (N = 12 healthy subjects) listened passively to previously recorded self- and other-related finger snapping sounds, presented either as deviants or standards during an oddball paradigm. Passive listening to low (500 Hz) and high (1000 Hz) pure tones served as additional control. For self- vs. other-related finger snapping sounds, analysis of ERPs revealed significant differences in the time windows of the N2a/MMN and P3. An subsequent source localization analysis with standardized low-resolution brain electromagnetic tomography (sLORETA) revealed increased cortical activation in distinct motor areas such as the supplementary motor area (SMA) in the N2a/mismatch negativity (MMN) as well as the P3 time window during processing of self- and other-related finger snapping sounds. In contrast, brain regions associated with self-related processing [e.g., right anterior/posterior cingulate cortex (ACC/PPC)] as well as the right inferior parietal lobule (IPL) showed increased activation particularly during processing of self- vs. other-related finger snapping sounds in the time windows of the N2a/MMN (ACC/PCC) or the P3 (IPL). None of these brain regions showed enhanced activation while listening passively to low (500 Hz) and high (1000 Hz) pure tones. Taken together, the current results indicate (1) a specific role of motor regions such as SMA during auditory processing of movement-related information, regardless of whether this information is self- or other-related, (2) activation of neural sources such as the ACC/PCC and the IPL during implicit processing of self-related movement stimuli, and (3

NASA Snaps Nighttime View of Massive Iceberg Split

NASA Image and Video Library

2017-07-25

As Antarctica remains shrouded in darkness during the Southern Hemisphere winter, the Thermal Infrared Sensor (TIRS) on Landsat 8 captured a new snap of the 2,240-square-mile iceberg that split off from the Antarctic Peninsula’s Larsen C ice shelf on July 10-12. The satellite imagery is a composite of Landsat 8 as it past on July 14 and July 21 and shows that the main berg, A-68, has already lost several smaller pieces. The A-68 iceberg is being carried by currents northward out of its embayment on the Larsen C ice shelf. The latest imagery also details a group of three small, not yet released icebergs at the north end of the embayment. Credits: NASA Goddard/UMBC JCET, Christopher A. Shuman NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Water-resources data for the United States: water year 2011

USGS Publications Warehouse

,

2011-01-01

Water resources data are published annually for use by engineers, scientists, managers, educators, and the general public. These archival products supplement direct access to current and historical water data provided by NWISWeb. Beginning with Water Year 2006, annual water data reports are available as individual electronic Site Data Sheets for the entire Nation for retrieval, download, and localized printing on demand. National distribution includes tabular and map interfaces for search, query, display and download of data. From 1962 until 2005, reports were published by State as paper documents, although most reports since the mid-1990s are also available in electronic form through this web page. Reports prior to 1962 were published in occasional USGS Water-Supply Papers and other reports.

Water-resources data for the United States: water year 2010

USGS Publications Warehouse

,

2010-01-01

Water resources data are published annually for use by engineers, scientists, managers, educators, and the general public. These archival products supplement direct access to current and historical water data provided by NWISWeb. Beginning with Water Year 2006, annual water data reports are available as individual electronic Site Data Sheets for the entire Nation for retrieval, download, and localized printing on demand. National distribution includes tabular and map interfaces for search, query, display and download of data. From 1962 until 2005, reports were published by State as paper documents, although most reports since the mid-1990s are also available in electronic form through this web page. Reports prior to 1962 were published in occasional USGS Water-Supply Papers and other reports.

Water-resources data for the United States: water year 2007

USGS Publications Warehouse

,

2007-01-01

Water resources data are published annually for use by engineers, scientists, managers, educators, and the general public. These archival products supplement direct access to current and historical water data provided by NWISWeb. Beginning with Water Year 2006, annual water data reports are available as individual electronic Site Data Sheets for the entire Nation for retrieval, download, and localized printing on demand. National distribution includes tabular and map interfaces for search, query, display and download of data. From 1962 until 2005, reports were published by State as paper documents, although most reports since the mid-1990s are also available in electronic form through this web page. Reports prior to 1962 were published in occasional USGS Water-Supply Papers and other reports.

Water-resources data for the United States: water year 2008

USGS Publications Warehouse

,

2008-01-01

Water resources data are published annually for use by engineers, scientists, managers, educators, and the general public. These archival products supplement direct access to current and historical water data provided by NWISWeb. Beginning with Water Year 2006, annual water data reports are available as individual electronic Site Data Sheets for the entire Nation for retrieval, download, and localized printing on demand. National distribution includes tabular and map interfaces for search, query, display and download of data. From 1962 until 2005, reports were published by State as paper documents, although most reports since the mid-1990s are also available in electronic form through this web page. Reports prior to 1962 were published in occasional USGS Water-Supply Papers and other reports.

47 CFR 63.63 - Emergency discontinuance, reduction, or impairment of service.

Code of Federal Regulations, 2010 CFR

2010-10-01

... impairment of service. 63.63 Section 63.63 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... AND IMPAIRMENT OF SERVICE BY COMMON CARRIERS; AND GRANTS OF RECOGNIZED PRIVATE OPERATING AGENCY STATUS Discontinuance, Reduction, Outage and Impairment § 63.63 Emergency discontinuance, reduction, or impairment of...

Effects of environmentally relevant concentrations of atrazine on gonadal development of snapping turtles (Chelydra serpentina).

PubMed

de Solla, Shane R; Martin, Pamela A; Fernie, Kimberly J; Park, Brad J; Mayne, Gregory

2006-02-01

The herbicide atrazine has been suspected of affecting sexual development by inducing aromatase, resulting in the increased conversion of androgens to estrogens. We used snapping turtles (Chelydra serpentina), a species in which sex is dependent on the production of estrogen through aromatase activity in a temperature-dependent manner, to investigate if environmentally relevant exposures to atrazine affected gonadal development. Eggs were incubated in soil to which atrazine was applied at a typical field application rate (3.1 L/ha), 10-fold this rate (31 L/ha), and a control rate (no atrazine) for the duration of embryonic development. The incubation temperature (25 degrees C) was selected to produce only males. Although some males with testicular oocytes and females were produced in the atrazine-treated groups (3.3-3.7%) but not in the control group, no statistical differences were found among treatments. Furthermore, snapping turtle eggs collected from natural nests in a corn field were incubated at the pivotal temperature (27.5 degrees C) at which both males and females normally would be produced, and some males had oocytes in the testes (15.4%). The presence of low numbers of males with oocytes may be a natural phenomenon, and we have limited evidence to suggest that the presence of normal males with oocytes may represent a feminizing effect of atrazine. Histological examination of the thyroid gland revealed no effect on thyroid morphology.

Entering the 60th year of Acta Astronautica

NASA Astrophysics Data System (ADS)

Chang, Yi-Wei; Chern, Jeng-Shing; Marec, Jean-Pierre

2014-04-01

The Acta Astronautica Journal was firstly published in 1955 as the official Journal of the International Astronautical Federation (IAF) with the title Astronautica Acta. It is entering its 60th year in 2014. In 1962, the Astronautica Acta became the official Journal of the International Academy of Astronautics (IAA) established in 1960. A total of 18 volumes had been published from 1955 to 1973 under the leadership of three Editor-in-Chiefs: F. Hecht, Theodore von Karman, and Martin Summerfield. In 1974, A.K. Oppenheim became the new Editor-in-Chief and several evolved changes were performed including change of the title to Acta Astronautica (for grammatical correctness), cover page change, and format change. From 1974 to 2010, another three Editor-in-Chiefs led the journal with 67 volumes published. They were A.K. Oppenheim, Jean-Pierre Marec, and Rupert Gerzer. The current Editor-in-Chief Jeng-Shing Chern (Rock) took over the job from 2011. Total pages and articles published in 2012 are 3586 and 356, respectively. Currently, the Acta Astronautica Editorial Board consists of one Editor-in-Chief, 15 Co-Editors, one Managing Editor and one Honorary Editor-in-Chief (Jean-Pierre Marec). After 59 years, the Acta Astronautica has become a well-known journal worldwide. Its current rank and impact factor are 7/63 and 0.701, respectively. This paper presents some of the details as well as new strategies and steps. In particular, supports from the IAA Academicians are mandatory and most welcome.

Field assessment of a snap bean ozone bioindicator system under elevated ozone and carbon dioxide in a free air system

USDA-ARS?s Scientific Manuscript database

Ozone-sensitive (S156) and -tolerant (R123 and R331) genotypes of snap bean (Phaseolus vulgaris L.) were tested as a plant bioindicator system for detecting O3 effects at current and future levels of tropospheric O3 and atmospheric CO2 under field conditions. Plants were exposed to reciprocal combi...

50 years of optics research [Invited].

PubMed

Schwider, Johannes

2013-01-01

The 50-year life span of Applied Optics covers also approximately the time I have been engaged in optics. I started in 1962 [1] with the Institute for Optics and Spectroscopy, which was one of several Academy Institutes (mission statement: "theoria cum praxi," G. Leibniz) located in Berlin-Adlershof on the area of the first airfield in Berlin dating back to the beginning of the 20th century.

Toward Co-operation; The Development of a Provincial Voice for Adult Education in British Columbia, 1953 to 1962.

ERIC Educational Resources Information Center

Selman, Gordon R.

This paper traces the origin and development of the British Columbia provincial adult education organization during 1953-62. A series of biannual conferences for those interested in adult education began in late 1954. A more formal structure, the British Columbia Adult Education Council, was created in 1957 and continued until 1962, when it was…

Federal Guidance Report No. 4: Estimates and Evaluation of Fallout in the United States from Nuclear Weapons Testing Conducted Through 1962

EPA Pesticide Factsheets

This Federal Radiation Council report includes a full study and analysis of fallout expected in 1963 from nuclear testing that occurred in the past. This report covers fallout expected from Soviet and United States tests through 1962.

Application and further characterization of the snap bean S156/R123 ozone biomonitoring system in relation to ambient air temperature

USDA-ARS?s Scientific Manuscript database

Increased mixing ratios of ground-level ozone threaten individual plants, plant communities and ecosystems. In this sense, ozone biomonitoring is of great interest. The ozone-sensitive S156 and the ozone-tolerant R123 genotypes of snap bean (Phaseolus vulgaris L.) have been proposed as a potential t...

75 FR 21050 - V-GPO, Inc., Valesc Holdings, Inc., Venture Stores, Inc., Vertigo Theme Parks, Inc. (f/k/a Snap2...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-22

... SECURITIES AND EXCHANGE COMMISSION [File No. 500-1] V-GPO, Inc., Valesc Holdings, Inc., Venture Stores, Inc., Vertigo Theme Parks, Inc. (f/k/a Snap2 Corp.), Videolan Technologies, Inc., VisionGateway... Commission that there is a lack of current and accurate information concerning the securities of Vertigo...

SNAP23-Dependent Surface Translocation of Leukotriene B4 (LTB4) Receptor 1 Is Essential for NOX2-Mediated Exocytotic Degranulation in Human Mast Cells Induced by Trichomonas vaginalis-Secreted LTB4

PubMed Central

Lee, Young Ah; Kim, Kyeong Ah; El-Benna, Jamel

2016-01-01

ABSTRACT Trichomonas vaginalis is a sexually transmitted parasite that causes vaginitis in women and itself secretes lipid mediator leukotriene B4 (LTB4). Mast cells are important effector cells of tissue inflammation during infection with parasites. Membrane-bridging SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are critical for fusion during exocytosis. Although T. vaginalis-derived secretory products (TvSP) have been shown to induce exocytosis in mast cells, information regarding the signaling mechanisms between mast cell activation and TvSP is limited. In this study, we found that SNAP23-dependent surface trafficking of LTB4 receptor 1 (BLT1) is required for nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2)-mediated exocytotic degranulation of mast cells induced by TvSP. First, stimulation with TvSP induced exocytotic degranulation and reactive oxygen species (ROS) generation in HMC-1 cells. Next, TvSP-induced ROS generation and exocytosis were strongly inhibited by transfection of BLT1 small interfering RNA (siRNA). TvSP induced trafficking of BLT1 from the cytosol to the plasma membrane. We also found that knockdown of SNAP23 abrogated TvSP-induced ROS generation, exocytosis, and surface trafficking of BLT1 in HMC-1 cells. By coimmunoprecipitation, there was a physical interaction between BLT1 and SNAP23 in TvSP-stimulated HMC-1 cells. Taken together, our results suggest that SNAP23-dependent surface trafficking of BLT1 is essential for exocytosis in human mast cells induced by T. vaginalis-secreted LTB4. Our data collectively demonstrate a novel regulatory mechanism for SNAP23-dependent mast cell activation of T. vaginalis-secreted LTB4 involving surface trafficking of BLT1. These results can help to explain how the cross talk mechanism between parasite and host can govern deliberately tissue inflammatory responses. PMID:27795355

SNAP23-Dependent Surface Translocation of Leukotriene B4 (LTB4) Receptor 1 Is Essential for NOX2-Mediated Exocytotic Degranulation in Human Mast Cells Induced by Trichomonas vaginalis-Secreted LTB4.

PubMed

Min, Arim; Lee, Young Ah; Kim, Kyeong Ah; El-Benna, Jamel; Shin, Myeong Heon

2017-01-01

Trichomonas vaginalis is a sexually transmitted parasite that causes vaginitis in women and itself secretes lipid mediator leukotriene B 4 (LTB 4 ). Mast cells are important effector cells of tissue inflammation during infection with parasites. Membrane-bridging SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complexes are critical for fusion during exocytosis. Although T. vaginalis-derived secretory products (TvSP) have been shown to induce exocytosis in mast cells, information regarding the signaling mechanisms between mast cell activation and TvSP is limited. In this study, we found that SNAP23-dependent surface trafficking of LTB 4 receptor 1 (BLT1) is required for nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2)-mediated exocytotic degranulation of mast cells induced by TvSP. First, stimulation with TvSP induced exocytotic degranulation and reactive oxygen species (ROS) generation in HMC-1 cells. Next, TvSP-induced ROS generation and exocytosis were strongly inhibited by transfection of BLT1 small interfering RNA (siRNA). TvSP induced trafficking of BLT1 from the cytosol to the plasma membrane. We also found that knockdown of SNAP23 abrogated TvSP-induced ROS generation, exocytosis, and surface trafficking of BLT1 in HMC-1 cells. By coimmunoprecipitation, there was a physical interaction between BLT1 and SNAP23 in TvSP-stimulated HMC-1 cells. Taken together, our results suggest that SNAP23-dependent surface trafficking of BLT1 is essential for exocytosis in human mast cells induced by T. vaginalis-secreted LTB 4 Our data collectively demonstrate a novel regulatory mechanism for SNAP23-dependent mast cell activation of T. vaginalis-secreted LTB 4 involving surface trafficking of BLT1. These results can help to explain how the cross talk mechanism between parasite and host can govern deliberately tissue inflammatory responses. Copyright © 2016 American Society for Microbiology.

19 CFR 207.63 - Circulation of draft questionnaires.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 3 2012-04-01 2012-04-01 false Circulation of draft questionnaires. 207.63... SUBSIDIZED EXPORTS TO THE UNITED STATES Five-Year Reviews § 207.63 Circulation of draft questionnaires. (a) The Director shall circulate draft questionnaires to the parties for comment in each full review. (b...

19 CFR 207.63 - Circulation of draft questionnaires.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 3 2011-04-01 2011-04-01 false Circulation of draft questionnaires. 207.63... SUBSIDIZED EXPORTS TO THE UNITED STATES Five-Year Reviews § 207.63 Circulation of draft questionnaires. (a) The Director shall circulate draft questionnaires to the parties for comment in each full review. (b...

19 CFR 207.63 - Circulation of draft questionnaires.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 3 2013-04-01 2013-04-01 false Circulation of draft questionnaires. 207.63... SUBSIDIZED EXPORTS TO THE UNITED STATES Five-Year Reviews § 207.63 Circulation of draft questionnaires. (a) The Director shall circulate draft questionnaires to the parties for comment in each full review. (b...

19 CFR 207.63 - Circulation of draft questionnaires.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 3 2014-04-01 2014-04-01 false Circulation of draft questionnaires. 207.63... SUBSIDIZED EXPORTS TO THE UNITED STATES Five-Year Reviews § 207.63 Circulation of draft questionnaires. (a) The Director shall circulate draft questionnaires to the parties for comment in each full review. (b...

19 CFR 207.63 - Circulation of draft questionnaires.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Circulation of draft questionnaires. 207.63... SUBSIDIZED EXPORTS TO THE UNITED STATES Five-Year Reviews § 207.63 Circulation of draft questionnaires. (a) The Director shall circulate draft questionnaires to the parties for comment in each full review. (b...

40 CFR 63.10006 - When must I conduct subsequent performance tests or tune-ups?

Code of Federal Regulations, 2012 CFR

2012-07-01

... applicable periodic HCl emissions tests according to Table 5 to this subpart and § 63.10007 at least... performance tests according to Table 5 to this subpart and § 63.10007 at least every year. (b) For affected... years (once every year for Hg) according to Table 5 and § 63.10007. Should subsequent emissions testing...

Ground-water storage depletion in Pahrump Valley, Nevada-California, 1962-75

USGS Publications Warehouse

Harrill, James R.

1982-01-01

During the 13-year period, February 1962 to February 1975, about 540,000 acre-feet of ground water was pumped from Pahrump Valley. This resulted in significant water-level declines along the base of the Pahrump and Manse fans where pumping was concentrated. Maximum observed net decline was slightly more than 60 feet. Much smaller declines occurred in the central valley, and locally, water levels in some shallow wells rose due to recharge derived from the deep percolation of irrigation water. The pumping resulted in about 219,000 acre-feet of storage depletion. Of this, 155,000 acre-feet was from the draining of unconsolidated material, 46,000 was from compaction of fine-grained sediments, and 18,000 acre-feet was from the elastic response of the aquifer and water. The total storage depletion was equal to about 40 percent of the total pumpage. The remaining pumped water was derived from the capture of natural ground-water discharge and reuse of pumped water that had recirculated back to ground water. Natural recharge to and discharge from the ground-water system is estimated to be 37,000 acre-feet per year. Of this, 18,000 acre-feet per year leaves the area as subsurface outflow through carbonate-rock aquifers which form a multivalley flow system. The extent of this system was not precisely determined by this study. The most probable discharge area for this outflow is along the flood plain of the Amargosa River between the towns of Shoshone and Tecopa. This outflow probably cannot be economically captured by pumping from Pahrump Valley. Consequently, the maximum amount of natural discharge available for capture is 19,000 acre-feet per year. This is larger than the 12,000 acre-feet per year estimated in a previous study; the difference is due to different techniques used in the analysis. As of 1975, pumping was causing an overdraft of 11,000 acre-feet per year on the ground-water system. No new equilibrium is probable in the foreseeable future. Water levels will

26 CFR 1.802-2 - Taxable years affected.

Code of Federal Regulations, 2012 CFR

2012-04-01

...) INCOME TAXES (CONTINUED) Life Insurance Companies § 1.802-2 Taxable years affected. Section 1.802(b)-1 is... Revenue Code of 1954, as amended by the Life Insurance Company Income Tax Act of 1959 (73 Stat. 112) and... Insurance Company Income Tax Act of 1959 (73 Stat. 112), section 3 of the Act of October 23, 1962 (76 Stat...

26 CFR 1.802-2 - Taxable years affected.

Code of Federal Regulations, 2014 CFR

2014-04-01

...) INCOME TAXES (CONTINUED) Life Insurance Companies § 1.802-2 Taxable years affected. Section 1.802(b)-1 is... Revenue Code of 1954, as amended by the Life Insurance Company Income Tax Act of 1959 (73 Stat. 112) and... Insurance Company Income Tax Act of 1959 (73 Stat. 112), section 3 of the Act of October 23, 1962 (76 Stat...

26 CFR 1.802-2 - Taxable years affected.

Code of Federal Regulations, 2011 CFR

2011-04-01

...) INCOME TAXES (CONTINUED) Life Insurance Companies § 1.802-2 Taxable years affected. Section 1.802(b)-1 is... Revenue Code of 1954, as amended by the Life Insurance Company Income Tax Act of 1959 (73 Stat. 112) and... Insurance Company Income Tax Act of 1959 (73 Stat. 112), section 3 of the Act of October 23, 1962 (76 Stat...

26 CFR 1.802-2 - Taxable years affected.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) INCOME TAXES (CONTINUED) Life Insurance Companies § 1.802-2 Taxable years affected. Section 1.802(b)-1 is... Revenue Code of 1954, as amended by the Life Insurance Company Income Tax Act of 1959 (73 Stat. 112) and... Insurance Company Income Tax Act of 1959 (73 Stat. 112), section 3 of the Act of October 23, 1962 (76 Stat...

Effects of ethylenediurea on snap bean at a range of ozone concentrations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, J.E.; Pursley, W.A.; Heagle, A.S.

Ethylenediurea (EDU) [N-[2-(2-Oxo-1-imidazolidinyl) ethyl]-N{prime}-phenylurea] often protects plants from visible foliar injury due ozone{sub 3}. A few studies have indicated that EDU can suppress plant growth and yield. Because of the potential value of EDU as a research and assessment tool, controlled field experiments with snap bean Phaseolus vulgaris L. ({open_quotes}BBL-290{close_quotes}) were performed to test the effectiveness of different EDU application rates used in open-top chambers in each of two experiments [charcoal-filtered (CF) air, nonfiltered (NF) air, and nominal O{sub 3} additions of 0.025 and 0.05 or 0.03 and 0.06 {mu}LL{sup -1}O{sub 3} to NF air]. Ethylenediurea was added biweekly tomore » the potting medium . The EDU treatment concentration were 0, 14, 28, 56, and 120 and 0, 8, 16, and 32 mg EDU (active) L{sup -1} of potting medium in experiments one and two, respectively. Ethylenediurea provided some protection against O{sub 3}-induced foliar injury and growth suppression in both experiments. Measurements of net carbon exchange rate (NCER) and carbohydrate status of the tissues reflected the protective effects of EDU. In the first experiment EDU caused visible foliar injury at some growth stages and suppressed growth. In the second experiment, visible foliar injury was not caused by EDU at any concentration, but pod biomass (yield) was suppressed by EDU in CF chambers. The differences may have been due to environmental conditions (i.e., hot and dry during the first experiment and cooler during the second). Ethylenediurea also affected biomass partitioning in the plants grown in CF air (relative biomass was increased in leaves and decreased in pods). The results indicate that although EDU does protect or partially protect snap bean against O{sub 3} injury, it may also affect physiology and growth. 27 refs., 6 tabs.« less

EFFECTS OF SIMULATED ACIDIC RAIN APPLIED ALONE AND IN COMBINATION WITH AMBIENT RAIN ON GROWTH AND YIELD OF FIELD-GROWN SNAP BEAN

EPA Science Inventory

Field-grown snap bean plants were treated with simulated acidic rain applied either alone or in combination with ambient rain and the effects on growth and yield were determined. In plots where ambient rain was excluded, a retractable canopy was activated to shield the crop. Four...

The American Citizen: 11 Years after High School. Volume II.

ERIC Educational Resources Information Center

Wise,.Lauress L.; And Others

A third follow-up survey of ninth and tenth grade Project Talent participants (1962 and 1963 high school classes) was done approximately eleven years after their expected graduation from high school to gather additional data on the educational, career, personal, and family experiences of these individuals and their reflections on the value of…

40 CFR 63.1165 - Recordkeeping requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Hydrochloric Acid Regeneration Plants § 63.1165 Recordkeeping requirements. (a) General recordkeeping... action. (2) The owner or operator of an acid regeneration plant shall also maintain records for 5 years...

40 CFR 63.1165 - Recordkeeping requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Hydrochloric Acid Regeneration Plants § 63.1165 Recordkeeping requirements. (a) General recordkeeping... action. (2) The owner or operator of an acid regeneration plant shall also maintain records for 5 years...

40 CFR 63.1165 - Recordkeeping requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Hydrochloric Acid Regeneration Plants § 63.1165 Recordkeeping requirements. (a) General recordkeeping... action. (2) The owner or operator of an acid regeneration plant shall also maintain records for 5 years...

KSC-S63-01207

NASA Image and Video Library

1962-02-20

CAPE CANAVERAL, Fla. -- Astronaut John H. Glenn Jr. enters his Mercury capsule, "Friendship 7," as he prepares for launch of the Mercury-Atlas rocket. On February 20, 1962, Glenn lifted off into space aboard his Mercury Atlas 6 MA-6 rocket and became the first American to orbit the Earth. After orbiting the Earth 3 times, Friendship 7 landed in the Atlantic Ocean 4 hours, 55 minutes and 23 seconds later, just East of Grand Turk Island in the Bahamas. Glenn and his capsule were recovered by the Navy Destroyer Noa, 21 minutes after splashdown. Photo credit: NASA

26 CFR 1.1402(e)(6)-1 - Certificates filed by fiduciaries or survivors on or before April 15, 1962.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Science practitioner, a waiver certificate on Form 2031 may be filed after June 30, 1961 (the date of enactment of the Social Security Amendments of 1961), and on or before April 16, 1962, by a fiduciary acting...)(C) of the Social Security Act. Such certificates shall be effective for the period prescribed in...

26 CFR 1.1402(e)(6)-1 - Certificates filed by fiduciaries or survivors on or before April 15, 1962.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Science practitioner, a waiver certificate on Form 2031 may be filed after June 30, 1961 (the date of enactment of the Social Security Amendments of 1961), and on or before April 16, 1962, by a fiduciary acting...)(C) of the Social Security Act. Such certificates shall be effective for the period prescribed in...

26 CFR 1.1402(e)(6)-1 - Certificates filed by fiduciaries or survivors on or before April 15, 1962.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Science practitioner, a waiver certificate on Form 2031 may be filed after June 30, 1961 (the date of enactment of the Social Security Amendments of 1961), and on or before April 16, 1962, by a fiduciary acting...)(C) of the Social Security Act. Such certificates shall be effective for the period prescribed in...

Sugar-snap cookie dough setting: the impact of sucrose on gluten functionality.

PubMed

Pareyt, Bram; Brijs, Kristof; Delcour, Jan A

2009-09-09

In sugar-snap cookie making, sucrose influences the physicochemical transformations of the flour components and is responsible for both cookie sweetness and texture. Sucrose, together with low moisture levels, raises the starch gelatinization temperature to such an extent that little if any of it gelatinizes during baking. However, there is no agreement on the effects that it has on gluten during cookie making. The present study revealed that increasing sucrose levels in the recipe increasingly delay or inhibit gluten cross-linking, as judged from the loss of sodium dodecyl sulfate-extractable protein. This causes cookies containing higher sucrose levels to set later and to have a larger diameter. Gluten entanglement and/or cross-linking result in resistance to collapse, at the same time, cause setting during baking and, hence, determine cookie diameter.

46 CFR 160.060-3a - Materials-Dee ring and snap hook assemblies and other instruments of closure for buoyant vests.

Code of Federal Regulations, 2011 CFR

2011-10-01

... instruments of closure for buoyant vests. 160.060-3a Section 160.060-3a Shipping COAST GUARD, DEPARTMENT OF... LIFESAVING EQUIPMENT Specification for a Buoyant Vest, Unicellular Polyethylene Foam, Adult and Child § 160.060-3a Materials—Dee ring and snap hook assemblies and other instruments of closure for buoyant vests...

46 CFR 160.060-3a - Materials-Dee ring and snap hook assemblies and other instruments of closure for buoyant vests.

Code of Federal Regulations, 2013 CFR

2013-10-01

... instruments of closure for buoyant vests. 160.060-3a Section 160.060-3a Shipping COAST GUARD, DEPARTMENT OF... LIFESAVING EQUIPMENT Specification for a Buoyant Vest, Unicellular Polyethylene Foam, Adult and Child § 160.060-3a Materials—Dee ring and snap hook assemblies and other instruments of closure for buoyant vests...

46 CFR 160.060-3a - Materials-Dee ring and snap hook assemblies and other instruments of closure for buoyant vests.

Code of Federal Regulations, 2012 CFR

2012-10-01

... instruments of closure for buoyant vests. 160.060-3a Section 160.060-3a Shipping COAST GUARD, DEPARTMENT OF... LIFESAVING EQUIPMENT Specification for a Buoyant Vest, Unicellular Polyethylene Foam, Adult and Child § 160.060-3a Materials—Dee ring and snap hook assemblies and other instruments of closure for buoyant vests...

46 CFR 160.060-3a - Materials-Dee ring and snap hook assemblies and other instruments of closure for buoyant vests.

Code of Federal Regulations, 2014 CFR

2014-10-01

... instruments of closure for buoyant vests. 160.060-3a Section 160.060-3a Shipping COAST GUARD, DEPARTMENT OF... LIFESAVING EQUIPMENT Specification for a Buoyant Vest, Unicellular Polyethylene Foam, Adult and Child § 160.060-3a Materials—Dee ring and snap hook assemblies and other instruments of closure for buoyant vests...

Atrazine alters expression of reproductive and stress genes in the developing hypothalamus of the snapping turtle, Chelydra serpentina.

PubMed

Russart, Kathryn L G; Rhen, Turk

2016-07-29

Atrazine is an herbicide used to control broadleaf grasses and a suspected endocrine disrupting chemical. Snapping turtles lay eggs between late May and early June, which could lead to atrazine exposure via field runoff. Our goal was to determine whether a single exposure to 2ppb or 40ppb atrazine during embryogenesis could induce short- and long-term changes in gene expression within the hypothalamus of snapping turtles. We treated eggs with atrazine following sex determination and measured gene expression within the hypothalamus. We selected genes a priori for their role in the hypothalamus-pituitary-gonad or the hypothalamus-pituitary-adrenal axes of the endocrine system. We did not identify any changes in gene expression 24-h after treatment. However, at hatching AR, Kiss1R, and POMC expression was upregulated in both sexes, while expression of CYP19A1 and PDYN was increased in females. Six months after hatching, CYP19A1 and PRLH expression was increased in animals treated with 2ppb atrazine. Our study shows persistent changes in hypothalamic gene expression due to low-dose embryonic exposure to the herbicide atrazine with significant effects in both the HPG and HPA axes. Effects reported here appear to be conserved among vertebrates. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Hydrologic characterization for Spring Creek and hydrologic budget and model scenarios for Sheridan Lake, South Dakota, 1962-2007

USGS Publications Warehouse

Driscoll, Daniel G.; Norton, Parker A.

2009-01-01

The U.S. Geological Survey cooperated with South Dakota Game, Fish and Parks to characterize hydrologic information relevant to management of water resources associated with Sheridan Lake, which is formed by a dam on Spring Creek. This effort consisted primarily of characterization of hydrologic data for a base period of 1962 through 2006, development of a hydrologic budget for Sheridan Lake for this timeframe, and development of an associated model for simulation of storage deficits and drawdown in Sheridan Lake for hypothetical release scenarios from the lake. Historically, the dam has been operated primarily as a 'pass-through' system, in which unregulated outflows pass over the spillway; however, the dam recently was retrofitted with an improved control valve system that would allow controlled releases of about 7 cubic feet per second (ft3/s) or less from a fixed depth of about 60 feet (ft). Development of a hydrologic budget for Sheridan Lake involved compilation, estimation, and characterization of data sets for streamflow, precipitation, and evaporation. The most critical data need was for extrapolation of available short-term streamflow records for Spring Creek to be used as the long-term inflow to Sheridan Lake. Available short-term records for water years (WY) 1991-2004 for a gaging station upstream from Sheridan Lake were extrapolated to WY 1962-2006 on the basis of correlations with streamflow records for a downstream station and for stations located along two adjacent streams. Comparisons of data for the two streamflow-gaging stations along Spring Creek indicated that tributary inflow is approximately proportional to the intervening drainage area, which was used as a means of estimating tributary inflow for the hydrologic budget. Analysis of evaporation data shows that sustained daily rates may exceed maximum monthly rates by a factor of about two. A long-term (1962-2006) hydrologic budget was developed for computation of reservoir outflow from

Flour mill stream blending affects sugar snap cookie and Japanese sponge cake quality and oxidative cross-linking potential of soft white wheat.

USDA-ARS?s Scientific Manuscript database

The purpose of this research was to study the functional differences between straight grade (75% extraction rate) and patent (60% extraction rate) flour blends from 28 genetically pure soft white and club wheat grain lots, as evidenced by variation in sugar snap cookie and Japanese sponge cake quali...

26 CFR 1.1402(e)(6)-1 - Certificates filed by fiduciaries or survivors on or before April 15, 1962.

Code of Federal Regulations, 2010 CFR

2010-04-01

... duties required by such order, or in the exercise of his profession as a Christian Science practitioner... Social Security Amendments of 1961), and on or before April 16, 1962, by a fiduciary acting for such individual's estate or by such individual's survivor within the meaning of section 205(c)(1)(C) of the Social...

Low-energy versus middle-energy extracorporeal shockwave therapy for the treatment of snapping scapula bursitis

PubMed Central

Acar, Nihat

2017-01-01

Objective: Extracorporeal shockwave therapy (ESWT) has been used successfully in treatment of musculoskeletal disorders. Our objective was to assess the effectiveness of low versus middle-energy ESWT on snapping scapula bursitis. Methods: Thirty-five patients, divided into two groups, group (L), received low-energy ESWT, group (M) received middle-energy ESWT. Groups were evaluated at 1,3,6 and 12 months using the Visual Analogue Scale (VAS), the Constant-Murley scoring (CMS) and the Roles and Maudsley criteria. Results: In groups (L) and (M), VAS average values after 1,3,6 months and one year were (43±5.17, 38±4.33, 28±4.18 and 19±3.39) and (37±4.85, 26±4.74, 21±4.45 and 7±3.42) respectively. At six and twelve months, statistical difference was detected, P (0.034, 0.026) respectively. After one year of completing the treatment, the average values of CMS were (83.5±6.44 and 91±5.33) respectively, P=0.046. Roles and Maudsley criteria demonstrated that, patients in group (L), 6 (35%) excellent, 5 (29%) good, 4 (24%) acceptable and 2 (12%) had poor results. Whereas, patients in group (M), 11 (61%) excellent, 3 (17%) good, 3 (17%) acceptable and 1 (5%) had poor results. Conclusion: Although low-energy ESWT showed good early-term results, but middle-energy ESWT protocol demonstrated better early-term, Mid-term, and late-term results. PMID:28523033

46 CFR 160.052-3a - Materials-Dee ring and snap hook assemblies and other instruments of closure for buoyant vests.

Code of Federal Regulations, 2014 CFR

2014-10-01

... instruments of closure for buoyant vests. 160.052-3a Section 160.052-3a Shipping COAST GUARD, DEPARTMENT OF... LIFESAVING EQUIPMENT Specification for a Buoyant Vest, Unicellular Plastic Foam, Adult and Child § 160.052-3a Materials—Dee ring and snap hook assemblies and other instruments of closure for buoyant vests. (a...

46 CFR 160.047-3a - Materials-Dee ring and snap hook assemblies and other instruments of closure for buoyant vests.

Code of Federal Regulations, 2014 CFR

2014-10-01

... instruments of closure for buoyant vests. 160.047-3a Section 160.047-3a Shipping COAST GUARD, DEPARTMENT OF... LIFESAVING EQUIPMENT Specification for a Buoyant Vest, Kapok or Fibrous Glass, Adult and Child § 160.047-3a Materials—Dee ring and snap hook assemblies and other instruments of closure for buoyant vests. (a...

46 CFR 160.047-3a - Materials-Dee ring and snap hook assemblies and other instruments of closure for buoyant vests.

Code of Federal Regulations, 2012 CFR

2012-10-01

... instruments of closure for buoyant vests. 160.047-3a Section 160.047-3a Shipping COAST GUARD, DEPARTMENT OF... LIFESAVING EQUIPMENT Specification for a Buoyant Vest, Kapok or Fibrous Glass, Adult and Child § 160.047-3a Materials—Dee ring and snap hook assemblies and other instruments of closure for buoyant vests. (a...

46 CFR 160.047-3a - Materials-Dee ring and snap hook assemblies and other instruments of closure for buoyant vests.

Code of Federal Regulations, 2011 CFR

2011-10-01

... instruments of closure for buoyant vests. 160.047-3a Section 160.047-3a Shipping COAST GUARD, DEPARTMENT OF... LIFESAVING EQUIPMENT Specification for a Buoyant Vest, Kapok or Fibrous Glass, Adult and Child § 160.047-3a Materials—Dee ring and snap hook assemblies and other instruments of closure for buoyant vests. (a...

46 CFR 160.052-3a - Materials-Dee ring and snap hook assemblies and other instruments of closure for buoyant vests.

Code of Federal Regulations, 2013 CFR

2013-10-01

... instruments of closure for buoyant vests. 160.052-3a Section 160.052-3a Shipping COAST GUARD, DEPARTMENT OF... LIFESAVING EQUIPMENT Specification for a Buoyant Vest, Unicellular Plastic Foam, Adult and Child § 160.052-3a Materials—Dee ring and snap hook assemblies and other instruments of closure for buoyant vests. (a...

46 CFR 160.047-3a - Materials-Dee ring and snap hook assemblies and other instruments of closure for buoyant vests.

Code of Federal Regulations, 2013 CFR

2013-10-01

... instruments of closure for buoyant vests. 160.047-3a Section 160.047-3a Shipping COAST GUARD, DEPARTMENT OF... LIFESAVING EQUIPMENT Specification for a Buoyant Vest, Kapok or Fibrous Glass, Adult and Child § 160.047-3a Materials—Dee ring and snap hook assemblies and other instruments of closure for buoyant vests. (a...

46 CFR 160.052-3a - Materials-Dee ring and snap hook assemblies and other instruments of closure for buoyant vests.

Code of Federal Regulations, 2011 CFR

2011-10-01

... instruments of closure for buoyant vests. 160.052-3a Section 160.052-3a Shipping COAST GUARD, DEPARTMENT OF... LIFESAVING EQUIPMENT Specification for a Buoyant Vest, Unicellular Plastic Foam, Adult and Child § 160.052-3a Materials—Dee ring and snap hook assemblies and other instruments of closure for buoyant vests. (a...