Earth System Science Education Alliance (ESSEA) IPY Modules

NASA Astrophysics Data System (ADS)

Blaney, L. S.; Myers, R. J.; Schwerin, T.

2008-12-01

The Earth System Science Education Alliance (ESSEA) is a National Science Foundation-supported program implemented by the Institute for Global Environmental Strategies (IGES) to improve the quality of geoscience instruction for pre-service, middle, and high school teachers. ESSEA increases teachers' access to quality materials, standards-based instructional methods and content knowledge. With additional support from NASA, the ESSEA program is being enhanced to reflect emphasis on the International Polar Year. From 1999-2005 the ESSEA program was based on a trio of online courses (for elementary, middle, and high school teachers), the courses have been used by 40 faculty at 20 institutions educating over 1,700 teachers in Earth system science. Program evaluation of original course participants indicated that the courses had significant impact on teachers Earth system content knowledge and beliefs about teaching and learning. Seventeen of the original participating institutions have continued to use the courses and many have developed new programs that incorporate the courses in Earth science education opportunities for teachers. Today the ESSEA program lists nearly 40 colleges and universities as participants. With NASA support, the K-4 course and modules have been revised to include topics and resources focusing on the International Polar Year. Additional modules examining the changes in black carbon, ice sheets and permafrost have been added for middle and high school levels. The new modules incorporate geoscience data and analysis tools into classroom instruction. By exploring IPY related topics and data, participating teachers and their students will develop new understandings about the interactions and dependencies of the Earth spheres and our polar regions. Changes in climate, air, water, and land quality and animal and plant populations make the news everyday. The ESSEA IPY modules will help teachers inform rather than frighten their students as they learn more about the characteristics and importance of our polar regions. One goal of IPY 2007-2008 is to increase the awareness, understanding and interest of school-age children in polar conditions and research. The inclusion of polar topics in the ESSEA courses and modules contributes to the achievement of that goal.

Measuring sperm whales from their clicks: Stability of interpulse intervals and validation that they indicate whale length

NASA Astrophysics Data System (ADS)

Rhinelander, Marcus Q.; Dawson, Stephen M.

2004-04-01

Multiple pulses can often be distinguished in the clicks of sperm whales (Physeter macrocephalus). Norris and Harvey [in Animal Orientation and Navigation, NASA SP-262 (1972), pp. 397-417] proposed that this results from reflections within the head, and thus that interpulse interval (IPI) is an indicator of head length, and by extrapolation, total length. For this idea to hold, IPIs must be stable within individuals, but differ systematically among individuals of different size. IPI stability was examined in photographically identified individuals recorded repeatedly over different dives, days, and years. IPI variation among dives in a single day and days in a single year was statistically significant, although small in magnitude (it would change total length estimates by <3%). As expected, IPIs varied significantly among individuals. Most individuals showed significant increases in IPIs over several years, suggesting growth. Mean total lengths calculated from published IPI regressions were 13.1 to 16.1 m, longer than photogrammetric estimates of the same whales (12.3 to 15.3 m). These discrepancies probably arise from the paucity of large (12-16 m) whales in data used in published regressions. A new regression is offered for this size range.

Validation of the NCCN-IPI for diffuse large B-cell lymphoma (DLBCL): the addition of β2 -microglobulin yields a more accurate GELTAMO-IPI.

PubMed

Montalbán, Carlos; Díaz-López, Antonio; Dlouhy, Ivan; Rovira, Jordina; Lopez-Guillermo, Armando; Alonso, Sara; Martín, Alejandro; Sancho, Juan M; García, Olga; Sánchez, Jose M; Rodríguez, Mario; Novelli, Silvana; Salar, Antonio; Gutiérrez, Antonio; Rodríguez-Salazar, Maria J; Bastos, Mariana; Domínguez, Juan F; Fernández, Rubén; Gonzalez de Villambrosia, Sonia; Queizan, José A; Córdoba, Raul; de Oña, Raquel; López-Hernandez, Andrés; Freue, Julian M; Garrote, Heidys; López, Lourdes; Martin-Moreno, Ana M; Rodriguez, Jose; Abraira, Víctor; García, Juan F

2017-03-01

The study included 1848 diffuse large B-cell lymphoma (DLBCL)patients treated with chemotherapy/rituximab. The aims were to validate the National Comprehensive Cancer Network International Prognostic Index (NCCN-IPI) and explore the effect of adding high Beta-2 microglobulin (β2M), primary extranodal presentation and intense treatment to the NCCN-IPI variables in order to develop an improved index. Comparing survival curves, NCCN-IPI discriminated better than IPI, separating four risk groups with 5-year overall survival rates of 93%, 83%, 67% and 49%, but failing to identify a true high-risk population. For the second aim the series was split into training and validation cohorts: in the former the multivariate model identified age, lactate dehydrogenase, Eastern Cooperative Oncology Group performance status, Stage III-IV, and β2M as independently significant, whereas the NCCN-IPI-selected extranodal sites, primary extranodal presentation and intense treatments were not. These results were confirmed in the validation cohort. The Grupo Español de Linfomas/Trasplante de Médula ósea (GELTAMO)-IPI developed here, with 7 points, significantly separated four risk groups (0, 1-3, 4 or ≥5 points) with 11%, 58%, 17% and 14% of patients, and 5-year overall survival rates of 93%, 79%, 66% and 39%, respectively. In the comparison GELTAMO IPI discriminated better than the NCCN-IPI. In conclusion, GELTAMO-IPI is more accurate than the NCCN-IPI and has statistical and practical advantages in that the better discrimination identifies an authentic high-risk group and is not influenced by primary extranodal presentation or treatments of different intensity. © 2017 John Wiley & Sons Ltd.

Scientific Data as the Core Legacy of IPY

NASA Astrophysics Data System (ADS)

Parsons, M. A.

2008-12-01

The interdisciplinary breadth of the International Polar Year is unprecedented. The IPY has explicit objectives to link researchers across different fields to address questions and issues lying beyond the scope of individual disciplines and to strengthen international coordination of research and enhance international collaboration and cooperation. The IPY Data Policy and Management Subcommittee have developed a policy to help meet these objectives and an international collaboration of investigators and data managers, the IPY Data and Information Service, are working to make IPY data widely available. I will present an overview of the primary data management considerations for IPY and how diverse organizations are making IPY and related data available. Centralized discovery mechanisms for widely distributed data plus targeted access mechanisms for specific disciplines will be presented. These range from near real time access to satellite remote sensing data and GCM output to fair and appropriate access to traditional knowledge of the Arctic. These mechanisms reflect significant advancement in polar data management, but they belie the major challenges that remain. These challenges include fostering a culture change in science that puts greater value on data publication and open data access as well as developing sustained systems and business models for the long-term preservation of IPY data. This will be crucial to ensuring the legacy of IPY, a major objective of IPY sponsors, ICSU and WMO. New efforts to ensure this legacy include the development of the WMO Information System, the Sustained Arctic Observing Network, and the Global Earth Observing System of Systems; the reform of ICSU's World Data Center System; and the results of the Electronic Geophysical Year.

Earth Science Research as IPY Priority

NASA Astrophysics Data System (ADS)

Kotlyakov, V.; Leonov, Y.; Coakley, B.; Grikurov, G.; Johnson, L.; Kaminsky, V.; Kristoffersen, Y.; Leitchenkov, G.; Pavlenko, V.

2004-05-01

The preparations for IPY 2007/2008 are evolving from conceptual to implementation planning. Many earth scientists are concerned that the emerging plans for IPY are too narrowly focused on environmental processes and therefore appear discriminatory with respect to other fundamental sciences. National/international efforts such as USGCRP (U.S. Global Change Research program) and IPCC (Intergovernmental Panel on Climate Change) are also involved in the multitude of climate change issues, and just how the proposed IPY program could augment and complement these ongoing activities without reproducing them requires careful analysis and coordination. In particular, the polar research is unthinkable without study of the geological history of the Arctic and the Southern Oceans as a clue to tectonic evolution of the entire planet and test of the current geodynamic paradigm. In addition to these fundamental objectives, the circum-polar continental margins of the Arctic and Antarctica are likely to become the scenes of geopolitical intrigue provoked by implementation of the provisions of the Law of the Sea that require acquisition of specific earth science knowledge at internationally recognized levels of credibility. Interdisciplinary international programs (e. g. JEODI), based on geophysical data acquisition and analysis that would lead, where appropriate, to scientific drilling, had independently been proposed for studying the coupled tectonic and oceanographic history of the polar regions. Admitting the importance of identifying fundamental constraints for paleooceanography and climatic history of the high latitudes, and acknowledging the progress achieved so far in promoting IPY activities, the international earth science community has suggested developing the proposed approach into a major IPY endeavor - to examine the Polar Ocean Gateway Evolution (POGE). Such study would enable linking the geological history of the Polar Regions during the last 100 Ma and related fundamental changes that occurred in the face of the Earth with modern consequences of these processes and their impact on contemporary world. In good agreement with this project idea, although on a shorter time scale, is another initiative SALE (Subglacial Antarctic Lake Exploration) that has also been submitted for consideration in IPY context. It is hoped that IASC, SCAR and IUGS will take an active stand in endorsing earth science component of IPY, and that other bodies responsible for formulating IPY agenda will eventually recognize the fundamental importance of learning the past in order to understand the present and predict the future.

International Polar Year Observations From the International Space Station

NASA Technical Reports Server (NTRS)

Pettit, Donald R.; Runco, Susan; Byrne, Gregory; Willis, Kim; Heydorn, James; Stefanov, William L.; Wilkinson, M. Justin; Trenchard, Michael

2006-01-01

Astronauts aboard the International Space Station (ISS) have several opportunities each day to observe and document high-latitude phenomena. Although lighting conditions, ground track and other viewing parameters change with orbital precessions and season, the 51.6 degree orbital inclination and 400 km altitude of the ISS provide the crew an excellent vantage point for collecting image-based data for IPY investigators. To date, the database of imagery acquired by the Crew Earth Observations (CEO) experiment aboard the ISS (http://eol.jsc.nasa.gov) contains more than 12,000 images of high latitude (above 50 degrees) events such as aurora, mesospheric clouds, sea-ice, high-latitude plankton blooms, volcanic eruptions, and snow cover. The ISS Program will formally participate in IPY through an activity coordinated through CEO entitled Synchronized Observations of Polar Mesospheric Clouds, Aurora and Other Large-scale Polar Phenomena from the ISS and Ground Sites. The activity will augment the existing collection of Earth images taken from the ISS by focusing astronaut observations on polar phenomena. NASA s CEO experiment will solicit requests by IPY investigators for ISS observations that are coordinated with or complement ground-based polar studies. The CEO imagery website (http://eol.jsc.nasa.gov) will provide an on-line form for IPY investigators to interact with CEO scientists and define their imagery requests. This information will be integrated into daily communications with the ISS crews about their Earth Observations targets. All data collected will be cataloged and posted on the website for downloading and assimilation into IPY projects.

Unintended pregnancy and interpregnancy interval by maternal age, National Survey of Family Growth.

PubMed

Ahrens, Katherine A; Thoma, Marie E; Copen, Casey E; Frederiksen, Brittni N; Decker, Emily J; Moskosky, Susan

2018-03-01

The relationship between unintended pregnancy and interpregnancy interval (IPI) across maternal age is not clear. Using data from the National Survey of Family Growth, we estimated the percentages of pregnancies that were unintended among IPI groups (<6, 6-11, 12-17, 18-23, 24+ months) by maternal age at last live birth (15-19, 20-24, 25-29, 30-44 years). Approximately 40% of pregnancies were unintended and 36% followed an IPI<18 months. Within each maternal age group, the percentage of pregnancies that were unintended decreased as IPI increased. Unintended pregnancies are associated with shorter IPI across the reproductive age spectrum. Published by Elsevier Inc.

Cervical cancer screening in rural mountainous Honduras: knowledge, attitudes and barriers.

PubMed

Pryor, Rachel J; Masroor, Nadia; Stevens, Michael; Sanogo, Kakotan; Hernández O'Hagan, Pedro José; Bearman, Gonzalo

2017-01-01

Because cervical cancer is the leading cause of cancer mortality in Honduras, this study assessed knowledge, attitudes and barriers to cervical cancer screening services by Papanicolaou smear (pap smear) for women in rural, remote Honduras served by Virginia Commonwealth University's Global Health and Health Disparities Program (GH2DP). Two interviewers administered an institutional review board approved, 20 question survey by convenience sample methodology to adult female patients visiting GH2DP clinics in June 2014. A total of 146 surveys were completed. Of the respondents, 30 were living in La Hicaca, the largest and wealthiest village in the region, and 116 were living in surrounding, less affluent, villages. On average, women from La Hicaca had 2.9 children whereas women from surrounding villages had 4.3 children (p=0.0095). There were no significant differences between La Hicaca and surrounding villages in average respondent age, age of first intercourse and number of sexual partners. Seventy three percent (22/30) of women from La Hicaca and 60% (70/116) from surrounding villages reported undergoing cervical cancer screening by pap smear (p=0.1890). Eighty-two percent (18/22) of the respondents from La Hicaca and 84% (59/70) from surrounding villages were screened in the past two years (p=0.7846). The majority of the women from surrounding villages (81%, 57/70) and 23% (5/22) from La Hicaca traveled >1 h to receive a pap smear (p≤0.0001). Women from La Hicaca (86%, 19/22) were more likely to receive their pap smear results than women from surrounding villages (60%, 42/70) (p=0.0225). Although 17% (5/30) of respondents from La Hicaca and 11% (13/116) (p=0.4175) from surrounding villages were aware of the cause of cervical cancer, 60% (18/30) of women in La Hicaca and 82% (95/116) in surrounding villages (p=0.0106) believed it is preventable. Of the 106 women (73%) who had heard of cervical cancer screening, only 92 women (63%) had been screened (p<0.0001). Women undergoing cervical cancer screening were more likely to believe that cervical cancer is preventable (n=78, p=0.0054). The most common screening barriers were lack of awareness and fear (19/54, 35%; 15/54, 28%). Although yearly screening services are available in this community, knowledge and access barriers exist for increased implementation. Notification of pap smear results is suboptimal. These findings will guide regional and collaborative effort to improve cervical cancer screening services.

Celebrate with SATELLITES: An International Polar Year Partnership to Study Earth's Materials

ERIC Educational Resources Information Center

Hedley, Mikell Lynne; Czajkowski, Kevin; Struble, Janet; Benko, Terri; Shellito, Brad; Sheridan, Scott; Stasiuk, Mandy Munroe

2009-01-01

The SATELLITES program uses geospatial technologies to study surface temperatures of Earth's materials, such as sand, soil, grass, and water. Data are collected using Global Learning and Observations to Benefit the Environment (GLOBE) protocols, which are then used in research projects that are a part of the International Polar Year (IPY).…

PolarTREC-Celebrating the Legacy of the IPY Through Researcher-Educator Partnerships

NASA Astrophysics Data System (ADS)

Timm, K.; Warburton, J.; Larson, A. M.

2009-12-01

Polar TREC-Teachers and Researchers Exploring and Collaborating, a three-year (2007-2009) NSF-funded program, has matched over 40 teachers with polar researchers working in multiple scientific disciplines for 2-8 week Teacher Research Experiences (TRE) in the Arctic and Antarctica during the IPY. PolarTREC contributes to the legacy of the IPY through the creation and dissemination of polar education resources, prolonged teacher-researcher relationships, and contributions to scholarly knowledge on the impacts of TRE's. Products developed during PolarTREC are helping to sustain the widespread interest and enthusiasm in the polar regions generated during the IPY. During their expeditions, participating teachers brought science and information about profound changes at the poles to school, community, and professional audiences through web-based communications, journals, discussion forums, multimedia, and live events. PolarTREC teachers constructed nearly 100 classroom lesson plans and activities as products of their experiences. Live events from the field attracted over 11,000 participants, primarily K-12 students. Although the field experience is central to the PolarTREC TRE Model, many participants cite the relationship they built with their teacher/researcher as one of the best outcomes. Through personal communications, presentations at professional conferences, and continued support of each other’s work through classroom visits or joint proposal development, teachers and researchers have maintained the mutually beneficial relationships established during the IPY. Participating scientists gained access to professional educators with expertise in translating research approaches and results into programs. The need for researchers to explain their research and “boil it down to the raw essence” helped many see how their work fits into a bigger picture, often helping them communicate outside their scientific discipline and to diverse public audiences. Teachers, on the other hand, gained life-changing professional development and a network of science content experts who can help them in curriculum development. The IPY emphasized improved scientific understanding through innovative approaches to education and outreach programming. In initial PolarTREC evaluation data, participating teachers reported extensive increases in their knowledge of the Polar Regions, their use of effective science instruction methods, and their ability to teach the science concepts pertinent to their research experience. Students reported an increased understanding of general physical science concepts, topics related to the polar regions, and the importance of science for their future work and as a citizen in today’s world. Through participation in the IPY, PolarTREC provides a tested approach to TRE's that can be applied in the future to other contexts and locations. For more information, contact ARCUS at: info@polartrec.com or 907-474-1600.

Microbiological and ecological responses to global environmental changes in polar regions (MERGE): An IPY core coordinating project

NASA Astrophysics Data System (ADS)

Naganuma, Takeshi; Wilmotte, Annick

2009-11-01

An integrated program, “Microbiological and ecological responses to global environmental changes in polar regions” (MERGE), was proposed in the International Polar Year (IPY) 2007-2008 and endorsed by the IPY committee as a coordinating proposal. MERGE hosts original proposals to the IPY and facilitates their funding. MERGE selected three key questions to produce scientific achievements. Prokaryotic and eukaryotic organisms in terrestrial, lacustrine, and supraglacial habitats were targeted according to diversity and biogeography; food webs and ecosystem evolution; and linkages between biological, chemical, and physical processes in the supraglacial biome. MERGE hosted 13 original and seven additional proposals, with two full proposals. It respected the priorities and achievements of the individual proposals and aimed to unify their significant results. Ideas and projects followed a bottom-up rather than a top-down approach. We intend to inform the MERGE community of the initial results and encourage ongoing collaboration. Scientists from non-polar regions have also participated and are encouraged to remain involved in MERGE. MERGE is formed by scientists from Argentina, Australia, Austria, Belgium, Brazil, Bulgaria, Canada, Egypt, Finland, France, Germany, Italy, Japan, Korea, Malaysia, New Zealand, Philippines, Poland, Russia, Spain, UK, Uruguay, USA, and Vietnam, and associates from Chile, Denmark, Netherlands, and Norway.

"Live from IPY"--Connecting Students, Teachers and the Public to Polar Research

NASA Astrophysics Data System (ADS)

Breen, K.; Warnick, W. K.; Warburton, J.; Fischer, K.; Wiggins, H.

2007-12-01

PolarTREC-Teachers and Researchers Exploring and Collaborating is a three-year (2007-2009) teacher professional development program of the Arctic Research Consortium of the U.S. (ARCUS) that pairs K-12 teachers with researchers to improve science education through authentic polar research experiences. Each year of PolarTREC, approximately 15 teachers spend two to six weeks in the Arctic or Antarctic, working closely with researchers investigating a wide range of topics such as sea-ice dynamics, terrestrial ecology, marine biology, atmospheric chemistry, and long-term climate change. PolarTREC is funded by the National Science Foundation. While in the field, teachers and researchers communicate extensively with their colleagues, communities, and hundreds of students of all ages across the globe, using a variety of communication technologies and tools to appeal to broad student and public engagement in polar science. Through the PolarTREC website (www.polartrec.com) teachers connect from the field through the use of online journals and forums, photo galleries, podcasts, and learning resources. "Live from IPY," a key activity of PolarTREC, is a free, interactive, distance-learning experience that virtually transports students and the public to unique and remote polar locations through a live Internet interface. Rather than relying solely on the asynchronous elements of online journals, forums, photo albums, and podcasts, "Live from IPY" allows real-time interaction by adding elements including live voice, video, chat, application sharing, polling, and whiteboards, but requires only telephone and/or Internet access for participants and presenters to connect. "Live from IPY" and the online outreach elements of PolarTREC convey the excitement of polar research experiences to a broad audience far beyond the classrooms of the PolarTREC teachers, allowing anyone to join a global network of scientists, teachers, students, and communities and actively participate in the International Polar Year. Since January 2007, over 20 "Live from IPY" events have been held with more than 1700 participants, primarily K- 12 students, from 43 states across the US as well as international participants from 45 countries. "Live from IPY" has allowed educators to multiply the educational value of their expeditions, demonstrating the value that technology can bring to education by igniting thousands of young imaginations to the wonders of polar science.

Optimizing Communications Between Arctic Residents and IPY Scientific Researchers

NASA Astrophysics Data System (ADS)

Stapleton, M.; Carpenter, L.

2007-12-01

BACKGROUND International Polar Year, which was launched in March 2007, is an international program of coordinated, interdisciplinary scientific research on Earth's polar regions. The northern regions of the eight Arctic States (Canada, Alaska (USA), Russia, Sweden, Norway, Finland. Iceland and Greenland (Denmark) have significant indigenous populations. The circumpolar Arctic is one of the least technologically connected regions in the world, although Canada and others have been pioneers in developing and suing Information and Communication Technology (ICT) in remote areas. The people living in this vast geographic area have been moving toward taking their rightful place in the global information society, but are dependent on the outreach and cooperation of larger mainstream societies. The dominant medium of communication is radio, which is flexible in accommodating multiple cultures, languages, and factors of time and distance. The addition of newer technologies such as streaming on the Internet can increase access and content for all communities of interest, north and south. The Arctic Circle of Indigenous Communicators (ACIC) is an independent association of professional Northern indigenous media workers in the print, radio, television, film and Internet industries. ACIC advocates the development of all forms of communication in circumpolar North areas. It is international in scope. Members are literate in English, French, Russian and many indigenous languages. ACIC has proposed the establishment of a headquarters for monitoring IPY projects are in each area, and the use of community radio broadcasters to collect and disseminate information about IPY. The cooperation of Team IPY at the University of Colorado, Arctic Net at Laval University, and others, is being developed. ACIC is committed to making scientific knowledge gained in IPY accessible to those most affected - residents of the Arctic. ABSTRACT The meeting of the American Geophysical Union will be held in San Francisco on December 10 to 14, 2007. One component of this conference is entitled « Education, Outreach and Communications During IPY and Beyond ». ACIC proposes to present a discussion paper, « Optimizing Communications Between Arctic Residents and IPY Scientific Researchers », describing the status of IPY outreach and communications in the Arctic at this time. The paper will be complemented by photographs which illustrate the context of communication activity in these regions. ACIC has an existing international network of indigenous northern communicators. The IPY Northern Coordination Offices in Canada, and key informants in Alaska, RAIPON in the Russian Federation, and the Association of Sami Journalists, will be interviewed to determine involvement in IPY activities planned and/or undertaken. The level of community and professional awareness will be surveyed through interviews with community radio personnel. Aspirations and expectations for further cooperation with IPY reseearchers will be determined. Barriers and shortfalls will be identified. The usability and potential of current communications will be assessed. Endorsed IPY projects will be contacted to determine their Arctic communication plans and activities, barriers and opportunities. Information gained from the Joint Committee Assessment in October will be considered in the context of northern informant input. Conclusions and recommendations will reported, with the goal of optimizing opportunities to connect indigenous Arctic residents and IPY scientific research centres.

Cost-Effectiveness of Immune Checkpoint Inhibition in BRAF Wild-Type Advanced Melanoma

PubMed Central

Zeichner, Simon B.; Chen, Qiushi; Montero, Alberto J.; Goldstein, Daniel A.; Flowers, Christopher R.

2017-01-01

Purpose Patients who are diagnosed with stage IV metastatic melanoma have an estimated 5-year relative survival rate of only 17%. Randomized controlled trials of recent US Food and Drug Administration–approved immune checkpoint inhibitors—pembrolizumab (PEM), nivolumab (NIVO), and ipilumumab (IPI)—demonstrate improved patient outcomes, but the optimal treatment sequence in patients with BRAF wild-type metastatic melanoma remains unclear. To inform policy makers about the value of these treatments, we developed a Markov model to compare the cost-effectiveness of different strategies for sequencing novel agents for the treatment of advanced melanoma. Materials and Methods We developed Markov models by using a US-payer perspective and lifetime horizon to estimate costs (2016 US$) and quality-adjusted life years (QALYs) for treatment sequences with first-line NIVO, IPI, NIVO + IPI, PEM every 2 weeks, and PEM every 3 weeks. Health states were defined for initial treatment, first and second progression, and death. Rates for drug discontinuation, frequency of adverse events, disease progression, and death obtained from randomized phase III trials were used to determine the likelihood of transition between states. Deterministic and probabilistic sensitivity analyses were conducted to evaluate model uncertainty. Results PEM every 3 weeks followed by second-line IPI was both more effective and less costly than dacarbazine followed by IPI then NIVO, or IPI followed by NIVO. Compared with the first-line dacarbazine treatment strategy, NIVO followed by IPI produced an incremental cost effectiveness ratio of $90,871/QALY, and first-line NIVO + IPI followed by carboplatin plus paclitaxel chemotherapy produced an incremental cost effectiveness ratio of $198,867/QALY. Conclusion For patients with treatment-naive BRAF wild-type advanced melanoma, first-line PEM every 3 weeks followed by second-line IPI or first-line NIVO followed by second-line IPI are the most cost-effective, immune-based treatment strategies for metastatic melanoma. PMID:28221865

International Polar Year (IPY): Thinking Beyond Polar Bears and Penguins

NASA Astrophysics Data System (ADS)

Morris, P. A.; Reiff, P.; Austin, S.; Johnson, L.; Walter, D.

2008-12-01

The mention of an International Polar Year (IPY) to most of our university students evokes images of polar bears, penguins, perhaps some concepts of polar exploration in previous centuries. IPY provides an unusual opportunity to incorporate various aspects of polar research into the classroom, research opportunities as well as outreach activities. The subject areas that can be incorporated into classroom and undergraduate research activities would include astrobiology, atmospheric sciences, glaciation past and present. Astrobiology, in particular geomicrobiology in relation to the pursuit of life on other planets, is dependent on an understanding of extremophile organisms and the identifying signatures that can be chemical or morphological. Atmospheric studies using balloons with attached instruments enable us to understand the role of an atmosphere in providing a habitable world and filtering damaging rays from the Sun. L. Agassiz studied the patterns of glaciation and their alteration of the crustal surface today and the information enabled us to identify similar patterns in Earth's past and today are important for identifying polar glaciation on Mars. The wide variation of scientific opportunities and research information are also important for developing partnership and outreach programs whether elements are used for planetarium shows, exhibits at museums, hands-on activities, or leading students to pursue atmospheric studies. Each and every one of the components provides different avenues and the potential partnerships are limited only by one's creativity. One example of an effective partnership is the January NASA Space Day at the University of Texas at Brownsville, Texas. The event reaches over 600 primarily Hispanic students from the entire Rio Grande Valley. In January, 2009, the topic will be IPY and the popular Polar Palooza. The event will include exhibits, talks, and the new planetarium show Ice Worlds. The partners for this event include Johnson Space Center, Rice University, University of Houston-Downtown, Passport 2 Knowledge, the University of Texas at Brownsville and others. The end result is a cross-discipline scientific approach that incorporates a wide variety of programs and scientists.

Ice Stories: Engaging Polar Scientists as Field Correspondents for IPY

NASA Astrophysics Data System (ADS)

Miller, M. K.

2006-12-01

The International Polar Year (IPY 2007-09) gives the public, teachers, and students an extraordinary opportunity to experience the process of scientific discovery in action. The Exploratorium, working in partnership with international scientists at both poles, will create educational resources for museum and online visitors that celebrate life, legacy and science in the world's polar regions. In this session, Senior Science Producer Mary Miller will discuss the Exploratorium's proposed IPY project, Ice Stories. This unique educational project will provide a public face for IPY by using the power of contemporary media to bring current research to mass audiences with unprecedented intimacy and immediacy. Ice Stories includes: a media-rich, dynamic and continuously updated public Web site; a media-assets database for journalists, media producers, educators, and museum partners; a training program in media production and story-telling for polar scientists Ice Stories provides the public with access to IPY research through the development of a network of Exploratorium-trained polar field correspondents. It makes use of the design, education and production capacity of an informal science center to create a bridge between scientific discovery and interested members of the public. Ice Stories employs sophisticated media production and communication technology as well as strong partnerships with allied research groups and with scientists and international organizations at the poles. The Exploratorium has pioneered in translating current science research into exhibits and presentations accessible to museum and Web audiences. It also has long experience creating award-winning Web sites, professional-development workshops, community outreach, and institutional alliances.

Motor Unit Interpulse Intervals During High Force Contractions.

PubMed

Stock, Matt S; Thompson, Brennan J

2016-01-01

We examined the means, medians, and variability for motor-unit interpulse intervals (IPIs) during voluntary, high force contractions. Eight men (mean age = 22 years) attempted to perform isometric contractions at 90% of their maximal voluntary contraction force while bipolar surface electromyographic (EMG) signals were detected from the vastus lateralis and vastus medialis muscles. Surface EMG signal decomposition was used to determine the recruitment thresholds and IPIs of motor units that demonstrated accuracy levels ≥ 96.0%. Motor units with high recruitment thresholds demonstrated longer mean IPIs, but the coefficients of variation were similar across all recruitment thresholds. Polynomial regression analyses indicated that for both muscles, the relationship between the means and standard deviations of the IPIs was linear. The majority of IPI histograms were positively skewed. Although low-threshold motor units were associated with shorter IPIs, the variability among motor units with differing recruitment thresholds was comparable.

Coinfection with malaria and intestinal parasites, and its association with anaemia in children in Cameroon.

PubMed

Njunda, Anna Longdoh; Fon, Shuri Ghasarah; Assob, Jules Clement Nguedia; Nsagha, Dickson Shey; Kwenti, Tayong Dizzle Bita; Kwenti, Tebit Emmanuel

2015-10-06

The purpose of this study was to determine the prevalence of coinfection with malaria and intestinal parasites, as well as to determine its association with anaemia in children aged 10 years and below in Muyuka, Cameroon. This was a cross-sectional study. Participants were febrile children who were admitted to the Muyuka district hospital between April and October 2012. Blood and stool samples were collected from those participants who gave consent to take part in the study. Haemoglobin concentration (Hb) and complete blood count (CBC) were performed using an automated haematology analyser (Mindray®, BC-2800). Giemsa-stained blood film was examined to detect malaria parasites, while the formol-ether concentration technique was used to detect intestinal parasitic infections (IPIs). The Pearson's chi-square, Student's T-test and correlation analysis were all performed as part of the statistical analyses. Four hundred and eleven (411) children successfully took part in this study. The prevalence of malaria, IPIs, malaria and IPI coinfection, and anaemia observed were 98.5 %, 11.9 %, 11.9 % and 44.8 %, respectively. Anaemia and IPIs were significantly associated with age; anaemia was more prevalent in children under five years of age (p = 0.000), whereas IPIs were more prevalent in children aged between five and 10 years (p = 0.006). The parasite species isolated included Ascaris lumbricoides (36 [73.5 %]), Entamoeba histolytica/dispar (9 [18.4 %]) and hookworm (4 [8.2 %]). The mean Hb observed was 10.64 g/dl (±1.82). A significant negative correlation was observed between malaria parasite density and Hb. There was no significant difference in the prevalence of anaemia among children infected with malaria, IPIs, or malaria and IPI coinfection, or among non-infected children. Similarly, the mean Hb did not differ among infected and non-infected children. This study showed that malaria and IPIs still constitute a major public health problem in the study area despite a lack of any significant association between these infections and anaemia. The findings suggest that there is a need for the implementation of control measures to curb the rate of malaria and IPIs in the study area.

International Polar Research and Space Weather

NASA Astrophysics Data System (ADS)

Lanzerotti, Louis J.

2009-02-01

The fiftieth anniversary of the International Geophysical Year (IGY), currently celebrated in the 2007-2009 International Polar Year (IPY), highlights space weather's heritage from polar research. The polar regions were still very much "terra incognito" 50 years ago. At the same time, communications technologies had significantly advanced since the time of the second IPY, in 1932-1933. Yet even before the second IPY, several directors of international meteorological services stated in a 1928 resolution that "increased knowledge [of the polar regions] will be of practical application to problems connected with terrestrial magnetism, marine and aerial navigation, wireless telegraphy and weather forecasting" (see http://scaa.usask.ca/gallery/northern/currie/en_polaryear.shtml).

The International Polar Year in Portugal: A New National Polar Programme and a Major Education and Outreach project

NASA Astrophysics Data System (ADS)

Mendes-Victor, L.; Vieira, G.; Xavier, J.; Canario, A.

2008-12-01

Before the International Polar Year, in Portugal polar research was conducted by a very small group of scientists integrated in foreign projects or research institutions. Portugal was not member of the Scientific Committee for Antarctic Research (SCAR), the European Polar Board (EPB), neither a subscriber of the Antarctic Treaty. In 2004 Portuguese Polar researchers considered the IPY as an opportunity to change this situation and organized the national Committee for the IPY. The objectives were ambitious: to answer the aforementioned issues in defining and proposing a National Polar Programme. In late 2008, close to the end of the IPY, the objectives were attained, except the Antarctic Treaty signature that is, however, in an advanced stage, having been approved by consensus at the National Parliament in early 2007. Portugal joined SCAR in July 2006, the EPB in 2007 and a set of 5 Antarctic research projects forming the roots of the National Polar Programme (ProPolar) have been approved by the Foundation for Science and Technology (FCT-MCTES). Scientifically, the IPY can already be considered a major success in Portugal with an improvement in polar scientific research, in the number of scientists performing field work in the Antarctic, organizing polar science meetings and producing an expected increase in the number of polar science peer- reviewed papers. The Portuguese IPY scientific activities were accompanied by a major education and outreach project funded by the Agencia Ciência Viva (MCTES): LATITUDE60! Education for the Planet in the IPY. This project lead by the universities of Algarve, Lisbon and by the Portuguese Association of Geography Teachers is heavily interdisciplinary, programmed for all ages, from kindergarten to adults, and hoped to bring together scientists and society. LATITUDE60! was a major success and focussed on showing the importance of the polar regions for Earth's environment, emphasising on the implications of polar change for Portuguese society. Hundreds of events were organized, with activities lead by polar scientists and by about 400 teachers and thousands of students that got deeply involved in the IPY. The main activities were: the scientists go to school initiative, a national contest with over 8,000 participants that lead to a major exhibition and to the participation of 7 students in the Students on Ice Antarctic Expedition, an educational theatre play for kids presented n tens of schools, an IPY exhibition in the major shopping centers, public talks by scientists, production of educational materials (websites, a polar portal, on-line educational games, DVDs and class-oriented material), field stages with polar scientists, and the Polar Science Weekend with an attendance of over 7,000 people.

IPY 2007-2008

Science.gov Websites

Archiving IPY 2007-8 May 21, 2012 IPY IPY Report: May 2010 May 21, 2012 IPY IPY Report: April 2010 May 21 , 2012 IPY IPY Report: March 2010 May 21, 2012 IPY IPY Report: February 2010 May 21, 2012 IPY IPY Report : January 2010 May 21, 2012 IPY IPY Report: December 2009 May 21, 2012 IPY IPY Report: November 2009 May 21

Providing a Continuum of Leadership in Polar Science - An IPY Legacy

NASA Astrophysics Data System (ADS)

Baeseman, J.

2008-12-01

The Association of Polar Early Career Scientists (APECS) grew out of the 4th International Polar Year (IPY-4) 2007-08 and is an international and interdisciplinary organization of over 1200 undergraduate and graduate students, postdoctoral researchers, early faculty members, educators and others with interests in Polar Regions and the wider cryosphere from more than 40 countries. Our aims are to stimulate interdisciplinary and international research collaborations, and develop effective future leaders in polar research, education and outreach. As potentially one of the major legacies of IPY-4, APECS members have been at the forefront of increasing scientific knowledge and public interest in the polar regions, centered around global climate change, and enhancing scientific understanding, media attention, primary and secondary school (K-12) educational programs, and public literacy campaigns. Research and Educational Outreach activities by APECS members during IPY-4 have improved both our understanding and the communication of all aspects of the Polar Regions and the importance of their broader global connections. APECS National Committees have run Polar Contests where young researchers partnered with teachers and students to develop curriculum and activities to share their research, have participated in many field based communication exchanges and are mentoring youth to pursue careers in science, and enhancing the public perception of scientists through photo, video and museum exhibits. In cooperation with the IPY Teachers Network and the IPY IPO, APECS is developing a polar education resource book that will feature education and outreach activities by young researchers, as well as provide examples of classroom activities for teachers to incorporate polar literacy into their curriculum and a 'how to' guide for researchers interested in conducting education and outreach. As young researchers share their excitement and experiences in deepening our understanding of the polar regions, a new generation of polar literate people emerges and society benefits from more knowledge of the rapidly changing polar regions that have a critical and inherent global connection.

Front-Row Seat at the IPY: The Field Notes Electronic Newsletter

NASA Astrophysics Data System (ADS)

Rithner, P. K.; Zager, S. D.; Garcia-Lavigne, D. N.

2007-12-01

As employees of Polar Field Services/VPR, the arctic logistics provider to the US National Science Foundation, we bear witness to the exploration, documentation, and celebration of the International Polar Year (IPY). Our front- row vantage point (logisticians working with field scientists) offers us a rare opportunity to report on developments at the frontiers of polar research and to describe how scientists work in the Arctic. Our reporting mechanism is field notes, a weekly (summer) to monthly (winter) electronic digest of information about the IPY research we support. Each issue showcases a short "cover" piece highlighting science projects or profiling arctic program participants. In addition, field notes offers news updates, short interviews, and blog-style dispatches contributed by researchers and support personnel. Wherever possible, we include URLs so readers may find more information via the Web: we link to an online database of projects we maintain for the NSF, to university Web sites, project blogs, and so on. We aim to inform the interested layperson about the myriad of activity in the IPY. We like to show that arctic science is interesting, relevant--and a great adventure. We've found field notes to be an excellent outreach venue. By no means a slick media outlet, field notes is published "on the side" by a small but dedicated group of employees who are endlessly fascinated by, and who enjoy an engaging perspective on, contemporary arctic research. Newsletter

The IPY 2007-2008 data legacy - creating open data from IPY publications

NASA Astrophysics Data System (ADS)

Driemel, A.; Grobe, H.; Diepenbroek, M.; Grüttemeier, H.; Schumacher, S.; Sieger, R.

2015-09-01

The International Polar Year (IPY) 2007-2008 was a synchronized effort to simultaneously collect data from polar regions. Being the fourth in a series of IPYs, the demand for interdisciplinarity and new data products was high. However, despite all the research done on land, people, ocean, ice and atmosphere and the large amount of data collected, no central archive or portal was created for IPY data. In order to improve the availability and visibility of IPY data, a concerted effort between PANGAEA - Data Publisher for Earth and Environmental Science, the International Council for Science (ICSU) World Data System (WDS), and the International Council for Scientific and Technical Information (ICSTI) was undertaken to extract data resulting from IPY publications for long-term preservation. Overall, 1380 IPY-related references were collected. Of these, only 450 contained accessible data. All data were extracted, quality checked, annotated with metadata and uploaded to PANGAEA. The 450 articles dealt with a multitude of IPY topics - plankton biomass, water chemistry, ice thickness, whale sightings, Inuit health, alien species introductions by travellers or tundra biomass change, to mention just a few. Both the Arctic and the Antarctic were investigated in the articles, and all realms (land, people, ocean, ice and atmosphere) and a wide range of countries were covered. The data compilation can now be found with the identifier http://dx.doi.org/10.1594/PANGAEA.150150, and individual parts can be searched using the PANGAEA search engine (http://www.pangaea.de) and adding "+project:ipy". With this effort, we hope to improve the visibility, accessibility and long-term storage of IPY data for future research and new data products.

PolarTREC-Teachers and Researchers Exploring and Collaborating: Science Education from the Poles to the World

NASA Astrophysics Data System (ADS)

Warnick, W. K.; Breen, K.; Warburton, J.; Fischer, K.; Wiggins, H.; Owens, R.; Polly, B.; Wade, B.; Buxbaum, T.

2007-12-01

PolarTREC-Teachers and Researchers Exploring and Collaborating is a three-year (2007-2009) teacher professional development program celebrating the International Polar Year (IPY) that advances polar science education by bringing K-12 educators and polar researchers together in hands-on field experiences in the Arctic and Antarctic. Currently in its second year, the program fosters the integration of research and education to produce a legacy of long-term teacher-researcher collaborations, improved teacher content knowledge through experiences in scientific inquiry, and broad public interest and engagement in polar science. Through PolarTREC, over 40 U.S. teachers will spend two to six weeks in the Arctic or Antarctic, working closely with researchers in the field as an integral part of the science team. Research projects focus on a wide range of IPY science themed topics such as sea-ice dynamics, terrestrial ecology, marine biology, atmospheric chemistry, and long-term climate change. While in the field, teachers and researchers will communicate extensively with their colleagues, communities, and hundreds of students of all ages across the globe, using a variety of tools including satellite phones, online journals, podcasts and interactive "Live from IPY" calls and web-based seminars. The online outreach elements of the project convey these experiences to a broad audience far beyond the classrooms of the PolarTREC teachers. In addition to field research experiences, PolarTREC will support teacher professional development and a sustained community of teachers, scientists, and the public through workshops, Internet seminars, an e-mail listserve, and teacher peer groups. To learn more about PolarTREC visit the website at: http://www.polartrec.com or contact info@polartrec.com or 907-474-1600. PolarTREC is funded by NSF and managed by the Arctic Research Consortium of the US (ARCUS).

Standard International prognostic index remains a valid predictor of outcome for patients with aggressive CD20+ B-cell lymphoma in the rituximab era.

PubMed

Ziepert, Marita; Hasenclever, Dirk; Kuhnt, Evelyn; Glass, Bertram; Schmitz, Norbert; Pfreundschuh, Michael; Loeffler, Markus

2010-05-10

The International Prognostic Index (IPI) is widely used for risk stratification of patients with aggressive B-cell lymphoma. The introduction of rituximab has markedly improved outcome, and R-CHOP (rituximab + cyclophosphamide, doxorubicin, vincristine, prednisone) has become the standard treatment for CD20(+) diffuse large B-cell lymphoma. To investigate whether the IPI has maintained its power for risk stratification when rituximab is combined with CHOP, we analyzed the prognostic relevance of IPI in three prospective clinical trials. In total, 1,062 patients treated with rituximab were included (MabThera International Trial [MInT], 380 patients; dose-escalated regimen of cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone (MegaCHOEP) trial, 72 patients; CHOP + rituximab for patients older than age 60 years [RICOVER-60] trial, 610 patients). A multivariate proportional hazards modeling was performed for single IPI factors under rituximab on event-free, progression-free, and overall survival. IPI score was significant for all three end points. Rituximab significantly improved treatment outcome within each IPI group resulting in a quenching of the Kaplan-Meier estimators. However, IPI was a significant prognostic factor in all three end points and the ordering of the IPI groups remained valid. The relative risk estimates of single IPI factors and their order in patients treated with R-CHOP were similar to those found with CHOP. The effects of rituximab were superimposed on the effects of CHOP with no interactions between chemotherapy and antibody therapy. These results demonstrate that the IPI is still valid in the R-CHOP era.

Recent advance in polar seismology: Global impact of the International Polar Year

NASA Astrophysics Data System (ADS)

Kanao, Masaki; Zhao, Dapeng; Wiens, Douglas A.; Stutzmann, Éléonore

2015-03-01

The most exciting initiative for the recent polar studies was the International Polar Year (IPY) in 2007-2008. The IPY has witnessed a growing community of seismologists who have made considerable efforts to acquire high-quality data in polar regions. It also provided an excellent opportunity to make significant advances in seismic instrumentation of the polar regions to achieve scientific targets involving global issues. Taking these aspects into account, we organize and publish a special issue in Polar Science on the recent advance in polar seismology and cryoseismology as fruitful achievements of the IPY.

IPY 2007-2008 and Scientists, Science Organisations, and the Public

NASA Astrophysics Data System (ADS)

Carlson, D. J.

2006-12-01

An initial burst of enthusiasm resulted in more than 1000 expressions of interest and nearly 500 internationally coordinated proposals for polar research during IPY. An international committee has endorsed more than 200 of these proposals, and most other proposals and nearly all expressions of interest have found ways to join the endorsed programme. Ten nations have announced new IPY science funding totalling in excess of 300M USD for the two years of operations; several nations will make announcements soon. Most on-going funding for polar research, coming from at least 30 nations, approximately 1.6B USD over two years, will also support IPY activities. What should the thousands of scientists hoping to participate expect, personally and collectively? What should the overall science entity expect, during and after IPY? And, finally, what should the public expect, after much attention and the expenditure of 2B USD, not to mention the on-going and future costs of ice breakers and ice-monitoring satellites and polar bases? Many IPY scientists will initially experience disappointment. Funding, even with IPY infusions, will fall short of need, and initial proposal success rates will stay below 50% in almost every nation, far below in some nations. In many nations, however, a catch-up effect will occur, leading to more funds in 2008 or 2009 than in 2006 and 2007. A step-up effect will also occur, leading to increased on-going funds for polar research, although perhaps in smaller steps and in fewer countries than we might hope. Scientists should expect increased public attention to their work and increased demand for their cooperation and contribution to international data management and to public outreach. Individually and collectively, IPY scientists have the opportunity to interact with an amazing array of fellow scientists, exchanging experience and enthusiasm on topics from gravitational variations to genomic sequences to Gwich'in cultures. Science as an entity will feel the impact of IPY. IPY does not fit within any single science organisation, even one so vast as AGU. A true international IPY community will exist beyond existing organisational systems, and a full multidisciplinary IPY assembly will occur in partnership with but separate from existing events. IPY will stimulate and produce new data models and infrastructure that will allow future polar researchers and polar residents to access, share and explore gravitational, genomic, and Gwich'in information. IPY will also necessarily stir up murky issues between scientific research and the environment, including how mega-science programmes should reduce their own environmental impact and how science conducts its assessments of global environmental problems when its partners include commercial energy companies and when its information products might encourage expanded extractive activities. This IPY will inevitably produce an organisational, data and environmental legacy that will impact science and scientists of the future. The public will expect quick answers from IPY, to questions not necessarily of our choosing. We can expect that they will enjoy a wide array of films and programmes and books on polar themes. We will have failed if the global public does not also gain an improved understanding of polar science and of the global consequences of climate change, and an enhanced appreciation of the creativity, challenges, pleasures and disappointments of science and of the energies and enthusiasms of scientists.

Effect of interpregnancy interval on adverse pregnancy outcomes in northern Tanzania: a registry-based retrospective cohort study.

PubMed

Mahande, Michael J; Obure, Joseph

2016-06-07

Both short and long interpregnancy intervals have been associated with an increased risk of adverse pregnancy outcomes. There is limited information about the impact of interpregnancy interval on pregnancy (IPI) outcomes in Tanzania. The objective of this study was to assess the effect of IPI on adverse pregnancy outcomes. We performed a retrospective cohort study using maternally-linked data from Kilimanjaro Christian Medical Centre (KCMC) birth registry. A total of 17,030 singlet births from women who delivered singleton infant at KCMC from 2000 to 2010 were studied. Women with multi-fetal gestations and those who were referred from rural areas for various medical reasons were excluded. Outcome variables were preterm birth, low birth weight infants and perinatal death. A multiple logistic regression was used to assess the association between IPI and pregnancy outcomes. The median IPI was 36 months. Compared with IPIs of 24-36 months (referent group), short interpregnancy intervals (<24 months) was associated with preterm delivery (OR 1 · 52; 95 % CI 1.31-1.74); low birth weight (OR 1 · 61; 95 % CI 1 · 34-1.72) and perinatal death, (OR 1 · 63; 95 % CI 1.22-1.91). The IPI of 37-59 months or longer were also associated with higher risks of preterm birth and low birth weight, but not with perinatal death. Our study confirmed that both short and long IPI are independent risk factors for adverse pregnancy outcomes. These finding emphasize the importance of providing support for family planning programs which will support optimal IPI and improve pregnancy outcomes.

An Overview of the Upcoming International Polar Year

NASA Astrophysics Data System (ADS)

Carlson, D.

2006-05-01

The ICSU - WMO International Polar Year 2007 - 2008 has drawn extraordinary interest from scientists of many specialties and many nationalities. A cautious assessment prior to the IPY start shows more than 200 projects, each with at least10 and often 50 or more scientists from at least three different nations, addressing a wide range of physical, biological and social research topics in both polar regions. Adding students, engineers, technicians and all manner of talented support crew so essential to polar research, and accepting some limitations due to logistics and funding, it seems likely that IPY will involve several 10's of thousands of individuals from at least 60 nations. Much of the IPY research will represent redirection and new collaboration on the basis of existing funds, but several nations will implement substantial new research funding and enhanced logistical support during IPY. One of IPY's strongest scientific contributions will arise from a substantial effort to understand geophysical, biological, and even social linkages between northern and southern polar regions - these linkages will highlight the importance of polar science to global processes and issues. IPY will offer unprecedented data management and communication challenges and opportunities, internally among so broad a range of scientific disciplines and externally to science education systems at all levels and to the general public. Against a background of prominent and largely commercial events, including films, television series, museum exhibitions, and regular broadcast coverage, many polar institutions and individuals will consider local events, new educational materials, and new engagement strategies that can have an enormous impact on public perception of science. In its total science and outreach effort, IPY will provide a large step forward that AGU and other pre-eminent science organizations can use and should plan to sustain.

Diffuse large B-cell lymphoma: 10 years' real-world clinical experience with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisolone.

PubMed

Horvat, Matej; Zadnik, Vesna; Južnič Šetina, Tanja; Boltežar, Lučka; Pahole Goličnik, Jana; Novaković, Srdjan; Jezeršek Novaković, Barbara

2018-03-01

Treatment with rituximab plus a regimen of cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) for patients with diffuse large B-cell lymphoma (DLBCL) has proven efficacy in clinical trials. The present study investigated its application in clinical practice. This single-center, retrospective database analysis included patients with DLBCL treated at the Slovenian Institute of Oncology Ljubljana between 2004 and 2013. Overall survival (OS) and progression-free survival (PFS) were assessed according to International Prognostic Index (IPI) and revised IPI (R-IPI) categories. Overall, 573 patients with DLBCL were included in the study (median follow-up, 45.3 months; range, 0.1-143.0). Patients were categorized as IPI 'low' (n=170; 30%), 'low-intermediate' (n=134; 23%), 'high-intermediate' (n=129; 23%) and 'high' (n=140; 24%) risk. R-IPI groups were indicated with 'very good' (n=59; 10%), 'good' (n=245; 43%) and 'poor' (n=269; 47%) prognosis. Ten-year OS and PFS rates were 51 and 72%, respectively; median OS was 124 months and median PFS was not reached. Ten-year OS rates were 80 and 87% in low-risk and 'very good' prognosis groups, respectively, and 30 and 37% in high-risk and poor prognosis patients, respectively. This analysis of patients with DLBCL indicated that many patients treated with R-CHOP and R-CHOP-like regimens in the real-world setting have excellent outcomes.

Thermal state of permafrost in North America: a contribution to the international polar year

Treesearch

S.L. Smith; V.E. Romanovsky; A.G. Lewkowicz; C.R. Burn; M. Allard; G.D. Clow; K. Yoshikawa; J. Throop

2010-01-01

A snapshot of the thermal state of permafrost in northern North America during the International Polar Year (IPY) was developed using ground temperature data collected from 350 boreholes. More than half these were established during IPY to enhance the network in sparsely monitored regions. The measurement sites span a diverse range of ecoclimatic and geological...

Ice Stories: An Educational Collaboration between the Exploratorium and IPY Scientists.

NASA Astrophysics Data System (ADS)

Mary, M. K.

2007-12-01

The Exploratorium, a renowned interactive science museum in San Francisco, has launched a major NSF-funded public education project to highlight research in the Arctic and Antarctic during the International Polar Year. "Ice Stories" will partner museum media and web producers with polar scientists working in the field to bring their research to the Internet and museum audiences via live Webcasts, video clips, blogs, podcasts, and other media platforms. To prepare scientists for their role as field correspondents, the Exploratoirum will train a cohort of 20- 30 young investigators in media collection, production and narrative story telling during an intensive one-week workshop in San Francisco. The museum will curate the polar field reports, and other IPY news and education events, into a continuously updated Web portal on the Exploratorium's award-winning Website and highlight the ongoing research in museum programming, floor demonstrations, and exhibits. These unique collaborations between formal and informal science can serve as a model for other partnerships during major scientific endeavors beyond the International Polar Year.

The International Polar Year, 2007-2008, an opportunity to focus on infectious diseases in Arctic regions.

PubMed

Parkinson, Alan J

2008-01-01

On 3 occasions over the past 125 years, scientists from around the world have worked together to organize scientific and exploration activities in polar regions (www.ipy.org). The first International Polar Year (IPY) in 1881-1884 marked the first major coordinated international scientific initiative to collect standardized meteorological and geophysical data in polar regions. Fifteen expeditions led by 12 nations amassed a large amount of data, but the scientific value was diminished by disjointed publication efforts and lack of long-term institutional commitment; lessons were learned and corrected in subsequent polar years. The second IPY began in 1932. Forty-four nations led expeditions in the Arctic and Antarctic, resulting in greater understanding of the aurora, magnetism, and meteorology. Air and marine navigation, radio operations, and weather forecasting were greatly improved as a result. The third IPY, in 1957-58, was renamed the International Geophysical Year and capitalized on technologic advances developed during World War II. Technologic and scientific momentum was redirected toward research, particularly to studies of the upper atmosphere, a legacy that continues to the present day. Notable achievements included launching the first satellite, measurement of atmospheric greenhouse gases, delineating the system of mid-ocean ridges, and confirming the theory of plate tectonics.

Short interpregnancy interval and low birth weight: A role of parity.

PubMed

Merklinger-Gruchala, Anna; Jasienska, Grazyna; Kapiszewska, Maria

2015-01-01

Short interpregnancy intervals (IPI) and high parity may be synergistically associated with the risk of unfavorable pregnancy outcomes. This study tests if the effect of short IPI on the odds ratio for low birth weight (LBW, <2,500 g) differs across parity status. The study was carried out on the birth registry sample of almost 40,000 singleton, live-born infants who were delivered between the years 1995 and 2009 to multiparous mothers whose residence at the time of infant's birth was the city of Krakow. Multiple logistic regression analyses were used for testing the effect of IPI on the odds ratio (OR) for LBW, after controlling for employment, educational and marital status, parity, sex of the child, maternal and gestational age. Stratified analyses (according to parity) and tests for interaction were performed. Very short IPI (0-5 months) was associated with an increased OR for LBW, but only among high parity mothers with three or more births (OR = 2.64; 95% CI 1.45-4.80). The test for interaction between very short IPI and parity on the OR for LBW was statistically significant after adjustment for multiple comparisons (P = 0.04). Among low parity mothers (two births) no statistically significant associations were found between IPI and LBW after standardization. Parity may modify the association between short birth spacing and LBW. Women with very short IPI and high parity may have a higher risk of having LBW infants than those with very short IPI but low parity. © 2015 Wiley Periodicals, Inc.

Research and Teaching. Journey to the End of the Earth: Academic and Professional Benefits for Students Participating in a Field-Based Research Program in Antarctica

ERIC Educational Resources Information Center

Garcia, Claudia Venessa; Robertson, William H.; Lougheed, Vanessa; Tweedie, Craig; Velasco, Aaron

2013-01-01

With the need to increase minority representation in the polar sciences, a team of researchers from a southwestern United States public university developed an innovative field research experience entitled the International Polar Year-Research and Educational Opportunities in Antarctica for Minorities (IPY-ROAM). Supported by a National Science…

ANDRILL Education and Public Outreach: A Legacy of the IPY

NASA Astrophysics Data System (ADS)

Rack, F. R.; Huffman, L. T.; Reed, J.; Harwood, D. M.; Berg, M.; Diamond, J.; Fox, A.; Dahlman, L. E.; Levy, R. H.

2009-12-01

ANDRILL field projects during the IPY included the McMurdo Ice Shelf (MIS) and Southern McMurdo Sound (SMS) drilling projects, and the Mackay Sea Valley (MSV) and Offshore New Harbor (ONH) seismic surveys. ANDRILL's international network of scientists, engineers, students and educators work together to convey an understanding of geoscience research and the process of science to non-technical audiences. ANDRILL education and public outreach (EPO) program goals are to: (1) promote environmental and polar science literacy for all audiences; (2) develop and disseminate engaging resources for formal and informal education; (3) develop and nurture a network of polar science educators; (4) spark the curiosity of students and the general public; (5) encourage students to pursue careers in science; (6) challenge misconceptions about scientific research; (7) provide professional development opportunities for educators; and, (8) encourage inquiry teaching in science education. During the IPY, ANDRILL established partnerships with several IPY projects to enhance science literacy and promote the IPY in formal and informal education and outreach venues. ANDRILL-led initiatives include the ARISE (ANDRILL Research Immersion for Science Educators) Program, Project Iceberg, the FLEXHIBIT (FLEXible exHIBIT; in partnership with Antarctica’s Climate Secrets/IPY Engaging Antarctica), and the Project Circle. ANDRILL partnerships developed with several museums and school districts for teacher professional development workshops and a variety of public events. A polar learning community was created from the ARISE participants and their many contacts, the Project Circle participants, and interested educators who contacted ANDRILL. EPO activities are continuing in the post-IPY period with additional funding. The ARISE program has been successful in building a team of educators and a network of international collaborations across grade levels and cultures. The ANDRILL website has expanded to include project outcomes, video journals, ARISE blogs, and other resources. The web pages continue to provide key educational outcomes by providing resources for students, teachers and the general public. The FLEXHIBIT banners and posters focus on five (5) Antarctic themes with a booklet of polar science activities. The banners are translated into German, Italian, French, Spanish, and Kiwi English with Maori subheadings. Smaller FLEXHIBIT posters with activities on the backs have been bundled into Teachers Packets that include two DVDs of ANDRILL’s educational content. The FLEXHIBIT posters have been translated into Italian, Spanish and Arabic. ANDRILL has demonstrated the value of EPO and has invested time and resources to improve polar and climate science literacy. ANDRILL’s EPO efforts give teachers, students and the public exposure to key scientific findings regarding climate change and the new knowledge interpreted from the ANDRILL cores.

Young Researchers Engaged in Educational Outreach to Increase Polar Literacy

NASA Astrophysics Data System (ADS)

Raymond, M.; Baeseman, J.; Xavier, J.; Kaiser, B.; Vendrell-Simon, B.

2008-12-01

The Association of Polar Early Career Scientists (APECS) grew out of the 4th International Polar Year (IPY-4) 2007-08 and is an international and interdisciplinary organization of over 1200 undergraduate and graduate students, postdoctoral researchers, early faculty members, educators and others with interests in Polar Regions and the wider cryosphere from more than 40 countries. Our aims are to stimulate interdisciplinary and international research collaborations, and develop effective future leaders in polar research, education and outreach. As potentially one of the major legacies of IPY-4, APECS members have been at the forefront of increasing scientific knowledge and public interest in the polar regions, centered around global climate change, and enhancing scientific understanding, media attention, primary and secondary school (K-12) educational programs, undergraduate institutions, and public literacy campaigns. Research and Educational Outreach activities by APECS members during IPY-4 have improved both our understanding and the communication of all aspects of the Polar Regions and the importance of their broader global connections. APECS National Committees have run Polar Contests where young researchers partnered with teachers and students to develop curriculum and activities to share their research, have participated in many field based communication exchanges and are mentoring youth to pursue careers in science, and enhancing the public perception of scientists through photo, video and museum exhibits. In cooperation with the IPY Teachers Network and the IPY IPO, APECS is developing a polar education resource book that will feature education and outreach activities by young researchers, as well as provide examples of classroom activities for teachers to incorporate polar literacy into their curriculum and a How-To guide for researchers interested in conducting education and outreach. As young researchers interactively share their excitement and experiences in deepening our understanding of the polar regions, a new generation of polar literate people emerges and society benefits from more knowledge of the rapidly changing polar regions that have a critical and inherent global connection.

Prevalence of and risk factors for malaria, filariasis, and intestinal parasites as single infections or co-infections in different settlements of Gabon, Central Africa.

PubMed

M'bondoukwé, Noé Patrick; Kendjo, Eric; Mawili-Mboumba, Denise Patricia; Koumba Lengongo, Jeanne Vanessa; Offouga Mbouoronde, Christelle; Nkoghe, Dieudonné; Touré, Fousseyni; Bouyou-Akotet, Marielle Karine

2018-01-30

Malaria, filariasis, and intestinal parasitic infections (IPIs) are common and frequently overlap in developing countries. The prevalence and predictors of these infections were investigated in three different settlements (rural, semi-urban, and urban) of Gabon. During cross-sectional surveys performed from September 2013 to June 2014, 451 individuals were interviewed. In addition, blood and stool samples were analysed for the presence of Plasmodium, filarial roundworm, intestinal protozoan, and helminth infections. Intestinal parasitic infections (61.1%), including intestinal protozoa (56.7%) and soil-transmitted helminths (STHs) (22.2%), predominated, whereas Plasmodium falciparum (18.8%), Loa loa (4.7%), and Mansonella perstans (1.1%) were less prevalent. Filariasis and STHs were mainly found in rural settlements, whereas a higher plasmodial infection prevalence rate was observed in the periurban area. The most common IPI was blastocystosis (48.6%), followed by ascaridiasis (13.7%), trichuriasis (11.8%), amoebiasis (9.3%), giardiasis (4.8%), and strongyloidiasis (3.7%). Hookworm was detected in one adult from rural Dienga. Adults had a higher prevalence of Blastocystis hominis and STHs, whereas Giardia duodenalis was more frequently observed among children aged below 5 years (P < 0.01). The polyparasitism rate was 41.5%, with 7.0% Plasmodium-IPIs and 1.8% Plasmodium-STH co-infections. The multivariate analysis showed that living in a suburban area, belonging to the age group of 5-15 years, having none or a secondary education, or having an open body water close to home were significant risk factors for malaria (P ≤ 0.01). For STH infections, identified risk factors were drinking untreated water and living in a rural area (P ≤ 0.04). No significant predictors were identified for IPIs and malaria-IPI co-infection. This study reports a high prevalence of IPIs and intestinal protozoa, but a low rate of malaria-IPI co-infections in the study sites. Improvements in the living conditions of the population such as adequate water supply and proper health education and sanitation should be integrated into control strategies for malaria, STHs, and IPIs.

A New Model for Building Digital Science Education Collections

NASA Astrophysics Data System (ADS)

Niepold, F.; McCaffrey, M.; Morrill, C.; Ganse, J.; Weston, T.

2005-12-01

The Polar Regions play an integral role in how our Earth system operates. However, the Polar Regions are marginally studied in the K-12 classroom in the United States. The International Polar Year's (IPY) coordinated campaign of polar observations, research, and analysis that will be multidisciplinary in scope and international in participation offers a powerful opportunity for K-12 classroom. The IPY's scientific objective to better understand the key roles of the Polar Regions in global processes will allow students a window into the poles and this unique regions role in the Earth system. IPY will produce careful, useful scientific information that will advance our understanding of the Polar Regions and their connections to the rest of the globe. The IPY is an opportunity to inspire the next generation of very young Earth system scientists. The IPY's draft education & outreach position paper asks a key question that must guide future educational projects; "Why is the polar regions and polar research important to all people on earth?" In efforts to coordinate educational activities and collaborate with international projects, United States national agencies, and other educational initiatives, it is the purpose of this session to explore potential partnerships, while primarily recommending a model for educational product development and review. During such a large international science endeavor, numerous educational activities and opportunities are developed, but these educational programs can suffer from too many unconnected options being available to teachers and students. Additionally, activities often are incompatible with each other making classroom implementation unnecessarily complex and prohibitively time consuming for teachers. A newly develop educational activity collection technique developed for DLESE offers an effective model for IPY product gap analysis and development. The Climate Change Collection developed as a pilot project for the Digital Library for Earth System Education (DLESE Climate Change Collection, NSF Award Number 0435645) is a high-quality, annotated thematic collection of 40 seminal digital resources that were identified and annotated by a review team of science experts and educators, who examined digital resources for scientific accuracy, currency and usefulness to science educators. An experiment in digital science education collection development, the effort brought together a community of experts through an interdisciplinary review board supported by an extended network of climate scientists and educational researchers, developers, and practitioners. This work produced and refined a protocol for collection building that can be transferred to the IPY education effort. Time will be given to discussions and potential collaborations.

IPY 2007-2008 data legacy - a ong story cut short

NASA Astrophysics Data System (ADS)

Driemel, A.; Grobe, H.; Diepenbroek, M.; Grüttemeier, H.; Schumacher, S.; Sieger, R.

2015-06-01

The International Polar Year 2007-2008 was a synchronized effort to simultaneously collect data from polar regions. Being the fourth in a row of IPYs, the demand for interdisciplinarity and new data products was high. However, despite of all the research done on land, people, ocean, ice and atmosphere and the large amount of data collected, no central archive or portal was created for IPY data. In order to address these issues, a concerted effort between PANGAEA - Data Publisher for Earth and Environmental Science, the ICSU World Data System (WDS), and the International Council for Scientific and Technical Information (ICSTI) was undertaken to extract data resulting from IPY publications for long-term preservation. 1380 IPY-related references were collected. Out of these, only 450 contained accessible data. All data was extracted, quality checked, annotated with metadata and uploaded to PANGAEA. The 450 articles dealt with a multitude of IPY topics - plankton biomass, water chemistry, ice thickness, whale sightings, Inuit health, alien species introductions by travelers or tundra biomass change - to mention just a few. Both, the Arctic and the Antarctic were investigated in the articles, and all realms (land, people, ocean, ice and atmosphere) and a wide range of countries were covered. The data compilation can now be found with the identifier doi:10.1594/PANGAEA.150150 and individually searched for using the PANGAEA search engine (www.pangaea.de) and adding "+project:ipy". With this effort, we hope to improve the visibility, accessibility and long-term storage of IPY data for future research and new data products.

The International Space Station Supports International Polar Year (IPY)

NASA Technical Reports Server (NTRS)

Evans, Cynthia A.; Pettit, Donald R.

2007-01-01

Every day, ISS astronauts photograph designated sites and dynamic events on the Earth's surface using digital cameras equipped with a variety of lenses. Depending on observation parameters, astronauts can collect high resolution (4-6 m pixel size) or synoptic views (lower resolution but covering very large areas) digital data in 3 (red-green-blue) color bands. ISS crews have daily opportunities to document a variety of high-latitude phenomena. Although lighting conditions, ground track and other viewing parameters change with orbital precessions and season, the 51.6o orbital inclination and 400 km altitude of the ISS provide the crew an unique vantage point for collecting image-based data of polar phenomena, including surface observations to roughly 65o latitude, and upper atmospheric observations that reach nearly to the poles. During the 2007-2009 timeframe of the IPY, polar observations will become a scientific focus for the CEO experiment; the experiment is designated ISS-IPY. We solicit requests from scientists for observations from the ISS that are coordinated with or complement ground-based polar studies. The CEO imagery website for ISS-IPY provides an on-line form that allows IPY investigators to interact with CEO scientists and define their imagery requests. This information is integrated into daily communications with the ISS astronauts about their Earth Observations targets. All data collected are cataloged and posted on the website for downloading and assimilation into IPY projects. Examples of imagery and detailed information about scientific observations from the ISS can also be downloaded from the ISS-IPY web site.

Earth Science Teaching Strategies Used in the International Polar Year

NASA Astrophysics Data System (ADS)

Sparrow, E. B.

2009-04-01

There are many effective methods for teaching earth science education that are being successfully used during the fourth International Polar Year (IPY). Relevance of IPY and the polar regions is better understood using a systems thinking approach used in earth science education. Changes in components of the earth system have a global effect; and changes in the polar regions will affect the rest of the world regions and vice versa. Teaching strategies successfully used for primary, secondary, undergraduate and graduate student earth science education and IPY education outreach include: 1) engaging students in earth science or environmental research relevant to their locale; 2) blending lectures with research expeditions or field studies, 3) connecting students with scientists in person and through audio and video conferencing; 4) combining science and arts in teaching, learning and communicating about earth science and the polar regions, capitalizing on the uniqueness of polar regions and its inhabitants, and its sensitivity to climate change; and 5) integrating different perspectives: western science, indigenous and community knowledge in the content and method of delivery. Use of these strategies are exemplified in IPY projects in the University of the Arctic IPY Higher Education Outreach Project cluster such as the GLOBE Seasons and Biomes project, the Ice Mysteries e-Polar Books: An Innovative Way of Combining Science and Literacy project, the Resilience and Adaptation Integrative Graduate Education and Research Traineeship project, and the Svalbard Research Experience for Undergraduates project.

Closing the loop - Approaches to monitoring the state of the Arctic Mediterranean during the International Polar Year 2007-2008

NASA Astrophysics Data System (ADS)

Mauritzen, C.; Hansen, E.; Andersson, M.; Berx, B.; Beszczynska-Möller, A.; Burud, I.; Christensen, K. H.; Debernard, J.; de Steur, L.; Dodd, P.; Gerland, S.; Godøy, Ø.; Hansen, B.; Hudson, S.; Høydalsvik, F.; Ingvaldsen, R.; Isachsen, P. E.; Kasajima, Y.; Koszalka, I.; Kovacs, K. M.; Køltzow, M.; LaCasce, J.; Lee, C. M.; Lavergne, T.; Lydersen, C.; Nicolaus, M.; Nilsen, F.; Nøst, O. A.; Orvik, K. A.; Reigstad, M.; Schyberg, H.; Seuthe, L.; Skagseth, Ø.; Skarðhamar, J.; Skogseth, R.; Sperrevik, A.; Svensen, C.; Søiland, H.; Teigen, S. H.; Tverberg, V.; Wexels Riser, C.

2011-07-01

During the 4th International Polar Year 2007-2009 (IPY), it has become increasingly obvious that we need to prepare for a new era in the Arctic. IPY occurred during the time of the largest retreat of Arctic sea ice since satellite observations started in 1979. This minimum in September sea ice coverage was accompanied by other signs of a changing Arctic, including the unexpectedly rapid transpolar drift of the Tara schooner, a general thinning of Arctic sea ice and a double-dip minimum of the Arctic Oscillation at the end of 2009. Thanks to the lucky timing of the IPY, those recent phenomena are well documented as they have been scrutinized by the international research community, taking advantage of the dedicated observing systems that were deployed during IPY. However, understanding changes in the Arctic System likely requires monitoring over decades, not years. Many IPY projects have contributed to the pilot phase of a future, sustained, observing system for the Arctic. We now know that many of the technical challenges can be overcome. The Norwegian projects iAOOS-Norway, POLEWARD and MEOP were significant ocean monitoring/research contributions during the IPY. A large variety of techniques were used in these programs, ranging from oceanographic cruises to animal-borne platforms, autonomous gliders, helicopter surveys, surface drifters and current meter arrays. Our research approach was interdisciplinary from the outset, merging ocean dynamics, hydrography, biology, sea ice studies, as well as forecasting. The datasets are tremendously rich, and they will surely yield numerous findings in the years to come. Here, we present a status report at the end of the official period for IPY. Highlights of the research include: a quantification of the Meridional Overturning Circulation in the Nordic Seas (“ the loop”) in thermal space, based on a set of up to 15-year-long series of current measurements; a detailed map of the surface circulation as well as characterization of eddy dispersion based on drifter data; transport monitoring of Atlantic Water using gliders; a view of the water mass exchanges in the Norwegian Atlantic Current from both Eulerian and Lagrangian data; an integrated physical-biological view of the ice-influenced ecosystem in the East Greenland Current, showing for instance nutrient-limited primary production as a consequence of decreasing ice cover for larger regions of the Arctic Ocean. Our sea ice studies show that the albedo of snow on ice is lower when snow cover is thinner and suggest that reductions in sea ice thickness, without changes in sea ice extent, will have a significant impact on the arctic atmosphere. We present up-to-date freshwater transport numbers for the East Greenland Current in the Fram Strait, as well as the first map of the annual cycle of freshwater layer thickness in the East Greenland Current along the east coast of Greenland, from data obtained by CTDs mounted on seals that traveled back and forth across the Nordic Seas. We have taken advantage of the real-time transmission of some of these platforms and demonstrate the use of ice-tethered profilers in validating satellite products of sea ice motion, as well as the use of Seagliders in validating ocean forecasts, and we present a sea ice drift product - significantly improved both in space and time - for use in operational ice-forecasting applications. We consider real-time acquisition of data from the ocean interior to be a vital component of a sustained Arctic Ocean Observing System, and we conclude by presenting an outline for an observing system for the European sector of the Arctic Ocean.

Changes in the oral health of the children of Dili, Timor Leste, between 2002 and 2014.

PubMed

Babo Soares, Lucio F; Allen, Penny L; Kingi, Jenna; Roberts-Thomson, Kaye; Bettiol, Silvana; Crocombe, Leonard

2016-01-01

This research compared the oral health status of school children in Dili (the capital of Timor Leste) in 2002 and 2014. The 2014 oral health survey of Dili's children replicated the methods of an AusAID-supported oral health survey conducted in 2002. Equal numbers of children were invited to participate from four age groups (6-8, 9-11, 12-14 and 15-17 years). For the 2014 survey, the subdistricts of Dom Aleixo, Cristo Rei, Metinaro and Vera Cruz were randomly selected for inclusion. A questionnaire was used to collect data on demographics and oral health behaviours. Oral epidemiological examinations were conducted by four dentists and five dental nurses. The 2014 survey in Dili recruited 758 participants for the questionnaire and 655 children for the oral examination. In 2014, a lower proportion of children reported brushing their teeth the previous day (97% vs 100%, p=0.01) and a larger proportion reported having toothache (40% vs 19%, p<0.001) (sometimes to very often) during the previous 12 months. The mean number of decayed, missing or filled teeth in the primary plus permanent dentition (dmft + DMFT) was greater in 2014 than in 2002 (4.2 vs 3.5, p=0.01). There was no difference in the prevalence of decay in the primary dentition (39% vs 37%, p=0.61) or the mean number of decayed, missing or filled (dmft) teeth in the primary dentition in 2014 compared to 2002 (2.0 vs 1.8, p=0.47). However, the prevalence of decay in the permanent dentition was greater in 2014 (70% vs 53%, p<0.001) as was the mean DMFT (2.3 vs 1.7, p=0.04). The prevalence of gingival bleeding (65% vs 81%, p<0.001) and calculus (57% vs 86%, p<0.001) was lower in 2014. There was an increase in dental caries experiences in Dili school children between 2002 and 2014, associated with more permanent teeth dental caries experiences.

Determining intestinal parasitic infections (IPIs) in inmates from Kajang Prison, Selangor, Malaysia for improved prison management.

PubMed

Angal, Lorainne; Mahmud, Rohela; Samin, Sajideh; Yap, Nan-Jiun; Ngui, Romano; Amir, Amirah; Ithoi, Init; Kamarulzaman, Adeeba; Lim, Yvonne A L

2015-10-29

The prison management in Malaysia is proactively seeking to improve the health status of the prison inmates. Intestinal parasitic infections (IPIs) are widely distributed throughout the world and are still gaining great concern due to their significant morbidity and mortality among infected humans. In Malaysia, there is a paucity of information on IPIs among prison inmates. In order to further enhance the current health strategies employed, the present study aims to establish firm data on the prevalence and diversity of IPIs among HIV-infected and non-HIV-infected individuals in a prison, an area in which informed knowledge is still very limited. Samples were subjected to microscopy examination and serological test (only for Strongyloides). Speciation for parasites on microscopy-positive samples and seropositive samples for Strongyloides were further determined via polymerase chain reaction. SPSS was used for statistical analysis. A total of 294 stool and blood samples each were successfully collected, involving 131 HIV positive and 163 HIV negative adult male inmates whose age ranged from 21 to 69-years-old. Overall prevalence showed 26.5% was positive for various IPIs. The IPIs detected included Blastocystis sp., Strongyloides stercoralis, Entamoeba spp., Cryptosporidium spp., Giardia spp., and Trichuris trichiura. Comparatively, the rate of IPIs was slightly higher among the HIV positive inmates (27.5%) than HIV negative inmates (25.8%). Interestingly, seropositivity for S. stercoralis was more predominant in HIV negative inmates (10.4%) compared to HIV-infected inmates (6.9%), however these findings were not statistically significant. Polymerase chain reaction (PCR) confirmed the presence of Blastocystis, Strongyloides, Entamoeba histolytica and E. dispar. These data will enable the health care providers and prison management staff to understand the trend and epidemiological situations in HIV/parasitic co-infections in a prison. This information will further assist in providing evidence-based guidance to improve prevention, control and management strategies of IPIs co-infections among both HIV positive and HIV negative inmates in a prison environment.

The DADDI Project: Delivering a Working Prototype for Arctic Coastal Data

NASA Astrophysics Data System (ADS)

Wilson, B. E.; Parsons, M. A.; Palanisamy, G.

2006-12-01

A key element for the ultimate success of the International Polar Year (IPY) effort will be our ability to make the volumes of data collected in this work available and usable to researchers, both now and into the future. Ultimately, the IPY data will reside in a number of different repositories and will be accessed by users from a wide variety of disciplines and with a wide variety of needs. It is therefore important that appropriate informatics tools be developed and made available to the IPY community for indexing, searching, retrieving, and managing distributed polar data. Discovery, Access, and Delivery of Data for the IPY (DADDI) is a NASA-funded project involving multiple institutions, targeted at leveraging and evolving Earth Science informatics tools to meet the Informatics challenges of the IPY effort. To test our approaches, we have selected Arctic coastal data as a focus area for developing a working prototype of an IPY Informatics solution. Coastal areas are undergoing some of the most drastic changes within the polar regions and are also the area of most concentrated human activity at high latitudes. Coastal regions are also of interest to a broad range of disciplines and data customers, so this is an area where there is a high need for a robust Informatics infrastructure. In this presentation, I will review the requirements which we have collected for an information system to manage a dispersed collection of Arctic coastal data. I will then present the current version of the prototype which we are developing, discuss the ways in which the underlying tools can be leveraged out to other IPY- related areas, and discuss the lessons learned in developing this prototype information system.

Accounting for Cured Patients in Cost-Effectiveness Analysis.

PubMed

Othus, Megan; Bansal, Aasthaa; Koepl, Lisel; Wagner, Samuel; Ramsey, Scott

2017-04-01

Economic evaluations often measure an intervention effect with mean overall survival (OS). Emerging types of cancer treatments offer the possibility of being "cured" in that patients can become long-term survivors whose risk of death is the same as that of a disease-free person. Describing cured and noncured patients with one shared mean value may provide a biased assessment of a therapy with a cured proportion. The purpose of this article is to explain how to incorporate the heterogeneity from cured patients into health economic evaluation. We analyzed clinical trial data from patients with advanced melanoma treated with ipilimumab (Ipi; n = 137) versus glycoprotein 100 (gp100; n = 136) with statistical methodology for mixture cure models. Both cured and noncured patients were subject to background mortality not related to cancer. When ignoring cured proportions, we found that patients treated with Ipi had an estimated mean OS that was 8 months longer than that of patients treated with gp100. Cure model analysis showed that the cured proportion drove this difference, with 21% cured on Ipi versus 6% cured on gp100. The mean OS among the noncured cohort patients was 10 and 9 months with Ipi and gp100, respectively. The mean OS among cured patients was 26 years on both arms. When ignoring cured proportions, we found that the incremental cost-effectiveness ratio (ICER) when comparing Ipi with gp100 was $324,000/quality-adjusted life-year (QALY) (95% confidence interval $254,000-$600,000). With a mixture cure model, the ICER when comparing Ipi with gp100 was $113,000/QALY (95% confidence interval $101,000-$154,000). This analysis supports using cure modeling in health economic evaluation in advanced melanoma. When a proportion of patients may be long-term survivors, using cure models may reduce bias in OS estimates and provide more accurate estimates of health economic measures, including QALYs and ICERs. Copyright © 2017 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

International Polar Year (IPY), 2007-2008

USGS Publications Warehouse

,

2007-01-01

The International Polar Year is an intense scientific campaign to explore new frontiers in polar science, improve our understanding of the critical role of the polar regions in global processes, engage the public in polar discovery, and help attract the next generation of earth scientists. Participation in the IPY allows the USGS to celebrate this enduring tradition with the rest of the global polar research community and to renew our commitment to polar science at a time when the world is focused on the extraordinary changes happening in these regions.

Collaborative, International Efforts at Estimating Arctic Sea Ice Processes During IPY (Invited)

NASA Astrophysics Data System (ADS)

Overland, J. E.; Eicken, H.; Wiggins, H. V.

2009-12-01

Planning for the fourth IPY was conducted during a time of moderate decadal change in the Arctic. However, after this initial planning was completed, further rapid changes were seen, including a 39 % reduction in summer sea ice extent in 2007 and 2008 relative to the 1980s-1990s, loss of multi-year sea ice, and increased sea ice mobility. The SEARCH and DAMOCLES Programs endeavored to increase communication within the research community to promote observations and understanding of rapidly changing Arctic sea ice conditions during IPY. In May 2008 a web-based Sea Ice Outlook was initiated, an international collaborative effort that synthesizes, on a monthly basis throughout the summer, the community’s projections for September arctic sea ice extent. Each month, participating investigators provided a projection for the mean September sea ice extent based on spring and early summer data, along with a rationale for their estimates. The Outlook continued in summer of 2009. The Outlook is a method of rapidly synthesizing a broad range of remote sensing and field observations collected at the peak of the IPY, with analysis methods ranging from heuristic to statistical to ice-ocean model ensemble runs. The 2008 Outlook was a success with 20 groups participating and providing a median sea ice extent projection from June 2008 data of 4.4 million square kilometers (MSQK)—near the observed extent in September 2008 of 4.7 MSQK, and well below the 1979-2007 climatological extent of 6.7 MSQK. More importantly, the contrast of sea ice conditions and atmospheric forcing in 2008 compared to 2007 provided clues to the future fate of arctic sea ice. The question was whether the previous loss of multi-year ice and delay in autumn freeze-up in 2007 would allow sufficient winter thickening of sea ice to last through the summer 2008, promoting recovery from the 2007 minimum, or whether most first-year sea ice would melt out as in 2005 and 2007, resulting in a new record minimum extent. Ultimately, neither extreme was observed. For September 2009 the median projection based on June 2009 data was 4.6 MSQK. June and July conditions were favorable for another record ice loss, but atmospheric circulation and cloudiness in August slowed ice retreat, suggesting that the 2009 Outlook estimates will be too low. A conclusion of this IPY effort is that although it will be difficult for summer sea ice to return to 1990 conditions, it will also require near-perfect synchrony in physical forcing as in 2007 to produce the next major loss event. The Outlook plans to continue.

How To Promote Data Quality And Access? Publish It!

NASA Astrophysics Data System (ADS)

Carlson, D. J.; Pfeiffenberger, H.

2011-12-01

Started during IPY 2007-2008, the Earth System Science Data journal (Copernicus) has now 'tested the waters' of earth system data publishing for approximately 2 years with some success. The journal has published more than 30 data sets, of remarkable breadth and variety, all under a Creative Commons Attribution license. Users can now find well-described, quality-controlled and freely accessible data on soils, permafrost, sediment transport, ice sheets, surface radiation, ocean-atmosphere fluxes, ocean chemistry, gravity fields, and combined radar and web cam observations of the Eyjafjallajökull eruption plume. Several of the data sets derive specifically from IPY or from polar regions, but a large portion, including a substantial special issue on ocean carbon, cover broad temporal and geographic domains; the contributors themselves come from leading science institutions around the world. ESSD has attracted the particular interest of international research teams, particularly those who, as in the case of ocean carbon data, have spent many years gathering, collating and calibrating global data sets under long-term named programs, but who lack within those programs the mechanisms to distribute those data sets widely outside their specialist teams and to ensure proper citation credit for those remarkable collaborative data processing efforts. An in-progress special issue on global ocean plankton function types, again representing years of international data collaboration, provides a further example of ESSD utility to large research programs. We anticipate an interesting test case of parallel special issues with companion science journals - data sets in ESSD to accompany science publications in a prominent research journal. We see the ESSD practices and products as useful steps to increase quality of and access to important data sets.

A Role of hIPI3 in DNA Replication Licensing in Human Cells.

PubMed

Huang, Yining; Amin, Aftab; Qin, Yan; Wang, Ziyi; Jiang, Huadong; Liang, Lu; Shi, Linjing; Liang, Chun

2016-01-01

The yeast Ipi3p is required for DNA replication and cell viability in Sacharomyces cerevisiae. It is an essential component of the Rix1 complex (Rix1p/Ipi2p-Ipi1p-Ipi3p) that is required for the processing of 35S pre-rRNA in pre-60S ribosomal particles and for the initiation of DNA replication. The human IPI3 homolog is WDR18 (WD repeat domain 18), which shares significant homology with yIpi3p. Here we report that knockdown of hIPI3 resulted in substantial defects in the chromatin association of the MCM complex, DNA replication, cell cycle progression and cell proliferation. Importantly, hIPI3 silencing did not result in a reduction of the protein level of hCDC6, hMCM7, or the ectopically expressed GFP protein, indicating that protein synthesis was not defective in the same time frame of the DNA replication and cell cycle defects. Furthermore, the mRNA and protein levels of hIPI3 fluctuate in the cell cycle, with the highest levels from M phase to early G1 phase, similar to other pre-replicative (pre-RC) proteins. Moreover, hIPI3 interacts with other replication-initiation proteins, co-localizes with hMCM7 in the nucleus, and is important for the nuclear localization of hMCM7. We also found that hIPI3 preferentially binds to the origins of DNA replication including those at the c-Myc, Lamin-B2 and β-Globin loci. These results indicate that hIPI3 is involved in human DNA replication licensing independent of its role in ribosome biogenesis.

GAMBIT--Gamburtsev Aerogeophysical Mapping of Bedrock and Ice Targets During IPY

NASA Astrophysics Data System (ADS)

Studinger, M.; Finn, C. A.; Bell, R. E.; Gogineni, S.; Hayden, L.; Braaten, D.

2004-12-01

Antarctica is a key element in Earth's climatic and geodynamic systems, yet on the eve of the 50th anniversary of the International Geophysical Year, we lack fundamental geologic and geophysical data from the deep interior of this vast continent. Despite the central role that Antarctica has played in shaping the present global environment, fundamental, first-order parameters such as ice volume and stratigraphy, bedrock elevation, lithology, structure, age, and tectonic history remain poorly known over large portions of the continent, including the Gamburtsev Subglacial Mountains. Given the extensive ice cover, airborne geophysical data is the best and most cost-effective method to characterize broad areas of sub-ice basement and expand our knowledge of Antarctica. Under a program entitled, GAMBIT--Gamburtsev Aerogeophysical Mapping of Bedrock and Ice Targets, we propose to conduct airborne gravity, magnetic and radar surveys over the Gamburtsev Subglacial Mountains, a priority for geophysical and drilling studies by the solid Earth and glaciology communities for many years. This proposal will help develop long-range aerogeophysical capabilities and provide data to the Antarctic community within a year after collection to help answer fundamental science questions of global significance. By integrating these with international efforts during the IPY, we can maximize and broaden the use of all data sets. Specifically, we propose to image the East Antarctic ice sheet and bedrock with airborne geophysical surveys through the GAMBIT project in order to: 1) determine ice volume for mass balance calculations and identify internal layers reflecting the accumulation history of the East Antarctic ice sheet in the Gamburtsev Subglacial Mountains region; 2) characterize the gravity, magnetic, and elevation signatures of the East Antarctic crustal basement of the Gamburtsev Subglacial Mountains; 3) integrate these data with existing and new data collected during IPY over adjacent areas; 4) help coordinate IPY activities, including survey design, development of policies related to open access to data, and input to existing data bases; and 5) develop online resources for K-12 students and teachers; internships for journalism students; and involve undergraduate students and faculty in important project aspects such as mapping and display of geophysical data sets in order to cultivate under-represented student interest in science and engineering.

Advances through collaboration: sharing seismic reflection data via the Antarctic Seismic Data Library System for Cooperative Research (SDLS)

USGS Publications Warehouse

Wardell, N.; Childs, J. R.; Cooper, A. K.

2007-01-01

The Antarctic Seismic Data Library System for Cooperative Research (SDLS) has served for the past 16 years under the auspices of the Antarctic Treaty (ATCM Recommendation XVI-12) as a role model for collaboration and equitable sharing of Antarctic multichannel seismic reflection (MCS) data for geoscience studies. During this period, collaboration in MCS studies has advanced deciphering the seismic stratigraphy and structure of Antarctica’s continental margin more rapidly than previously. MCS data compilations provided the geologic framework for scientific drilling at several Antarctic locations and for high-resolution seismic and sampling studies to decipher Cenozoic depositional paleoenvironments. The SDLS successes come from cooperation of National Antarctic Programs and individual investigators in “on-time” submissions of their MCS data. Most do, but some do not. The SDLS community has an International Polar Year (IPY) goal of all overdue MCS data being sent to the SDLS by end of IPY. The community science objective is to compile all Antarctic MCS data to derive a unified seismic stratigraphy for the continental margin – a stratigraphy to be used with drilling data to derive Cenozoic circum-Antarctic paleobathymetry maps and local-to-regional scale paleoenvironmental histories.

A tale of two communities: intestinal polyparasitism among Orang Asli and Malay communities in rural Terengganu, Malaysia.

PubMed

Elyana, Fatin Nur; Al-Mekhlafi, Hesham M; Ithoi, Init; Abdulsalam, Awatif M; Dawaki, Salwa; Nasr, Nabil A; Atroosh, Wahib M; Abd-Basher, Mohamad Hafiz; Al-Areeqi, Mona A; Sady, Hany; Subramaniam, Lahvanya R; Anuar, Tengku Shahrul; Lau, Yee Ling; Moktar, Norhayati; Surin, Johari

2016-07-16

Intestinal parasitic infections (IPIs) are still major health problems in many developing countries including Malaysia, particularly in the poor and socioeconomically deprived rural and remote communities in Peninsular Malaysia. This study was conducted to determine the prevalence of IPIs and to identify the key factors associated with intestinal polyparasitism as well as to evaluate the knowledge, attitude and practices (KAP) on IPIs among rural Orang Asli and Malay communities in Terengganu, Malaysia. A cross-sectional study was conducted among 340 participants (165 Orang Asli and 175 Malay) aged ≤ 15 years from the Hulu Terengganu and Kemaman districts of Terengganu. Faecal samples were examined for the presence of intestinal parasites by using direct smear, formalin-ether sedimentation, trichrome stain, modified Ziehl Neelsen stain, in vitro cultivation in Jones' medium, Kato Katz and Harada Mori techniques. Demographic, socioeconomic, environmental and behavioural information of the participants and their KAP for IPIs were collected by using a pre-tested questionnaire. Overall, 149 (90.3 %) Orang Asli and 43 (24.6 %) Malay children were infected by at least one parasite species. The overall prevalences of intestinal polyparasitism among the Orang Asli and Malay were 68.5 % (113/165) and 14.3 % (25/175), respectively. Multiple logistic regression analysis showed that using unsafe water supply as a source for drinking water, the presence of domestic animals, not wearing shoes when outside, not washing vegetables before consumption, not washing hands after playing with soil, indiscriminate defecation and the low level of mother's education were the key risk factors for intestinal polyparasitism among the Orang Asli, while working mothers and the presence of domestic animals were the risk factors among the Malay children. Almost all the Malays were well aware about the IPIs while Orang Asli respondents had a poor level of related awareness. This study demonstrates that IPIs are highly prevalent in rural Terengganu, Malaysia. Community awareness about IPIs was found to be imperative in protecting Malay children from these infections. An integrated control programme for the prevention and control of IPIs is highly recommended for these communities, with a special emphasis on the Orang Asli population.

The Arctic Human Health Initiative: a legacy of the International Polar Year 2007–2009

PubMed Central

Parkinson, Alan J.

2013-01-01

Background The International Polar Year (IPY) 2007–2008 represented a unique opportunity to further stimulate cooperation and coordination on Arctic health research and increase the awareness and visibility of Arctic regions. The Arctic Human Health Initiative (AHHI) was a US-led Arctic Council IPY coordinating project that aimed to build and expand on existing International Union for Circumpolar Health (IUCH) and Arctic Council human health interests. The project aimed to link researchers with potential international collaborators and to serve as a focal point for human health research, education, outreach and communication activities during the IPY. The progress of projects conducted as part of this initiative up until the end of the Arctic Council Swedish chairmanship in May 2013 is summarized in this report. Design The overall goals of the AHHI was to increase awareness and visibility of human health concerns of Arctic peoples, foster human health research, and promote health strategies that will improve health and well-being of all Arctic residents. Proposed activities to be recognized through the initiative included: expanding research networks that will enhance surveillance and monitoring of health issues of concern to Arctic peoples, and increase collaboration and coordination of human health research; fostering research that will examine the health impact of anthropogenic pollution, rapid modernization and economic development, climate variability, infectious and chronic diseases, intentional and unintentional injuries, promoting education, outreach and communication that will focus public and political attention on Arctic health issues, using a variety of publications, printed and electronic reports from scientific conferences, symposia and workshops targeting researchers, students, communities and policy makers; promoting the translation of research into health policy and community action including implementation of prevention strategies and health promotion; and promoting synergy and strategic direction of Arctic human health research and health promotion. Results As of 31 March, 2009, the official end of the IPY, AHHI represented a total of 38 proposals, including 21 individual Expressions of Intent (EoI), and 9 full proposals (FP), submitted to the IPY Joint Committee for review and approval from lead investigators from the US, Canada, Greenland, Norway, Finland, Sweden and the Russian Federation. In addition, there were 10 National Initiatives (NI-projects undertaken during IPY beyond the IPY Joint Committee review process). Individual project details can be viewed at www.arctichealth.org. The AHHI currently monitors the progress of 28 individual active human health projects in the following thematic areas: health network expansion (5 projects), infectious disease research (7 projects), environmental health research (7 projects), behavioral and mental health research (4 projects), and outreach education and communication (5 projects). Conclusions While some projects have been completed, others will continue well beyond the IPY. The IPY 2007–2008 represented a unique opportunity to further stimulate cooperation and coordination on Arctic health research and increase the awareness and visibility of Arctic regions. PMID:23971017

The Arctic Human Health Initiative: a legacy of the International Polar Year 2007-2009.

PubMed

Parkinson, Alan J

2013-01-01

The International Polar Year (IPY) 2007-2008 represented a unique opportunity to further stimulate cooperation and coordination on Arctic health research and increase the awareness and visibility of Arctic regions. The Arctic Human Health Initiative (AHHI) was a US-led Arctic Council IPY coordinating project that aimed to build and expand on existing International Union for Circumpolar Health (IUCH) and Arctic Council human health interests. The project aimed to link researchers with potential international collaborators and to serve as a focal point for human health research, education, outreach and communication activities during the IPY. The progress of projects conducted as part of this initiative up until the end of the Arctic Council Swedish chairmanship in May 2013 is summarized in this report. The overall goals of the AHHI was to increase awareness and visibility of human health concerns of Arctic peoples, foster human health research, and promote health strategies that will improve health and well-being of all Arctic residents. Proposed activities to be recognized through the initiative included: expanding research networks that will enhance surveillance and monitoring of health issues of concern to Arctic peoples, and increase collaboration and coordination of human health research; fostering research that will examine the health impact of anthropogenic pollution, rapid modernization and economic development, climate variability, infectious and chronic diseases, intentional and unintentional injuries, promoting education, outreach and communication that will focus public and political attention on Arctic health issues, using a variety of publications, printed and electronic reports from scientific conferences, symposia and workshops targeting researchers, students, communities and policy makers; promoting the translation of research into health policy and community action including implementation of prevention strategies and health promotion; and promoting synergy and strategic direction of Arctic human health research and health promotion. As of 31 March, 2009, the official end of the IPY, AHHI represented a total of 38 proposals, including 21 individual Expressions of Intent (EoI), and 9 full proposals (FP), submitted to the IPY Joint Committee for review and approval from lead investigators from the US, Canada, Greenland, Norway, Finland, Sweden and the Russian Federation. In addition, there were 10 National Initiatives (NI-projects undertaken during IPY beyond the IPY Joint Committee review process). Individual project details can be viewed at www.arctichealth.org. The AHHI currently monitors the progress of 28 individual active human health projects in the following thematic areas: health network expansion (5 projects), infectious disease research (7 projects), environmental health research (7 projects), behavioral and mental health research (4 projects), and outreach education and communication (5 projects). While some projects have been completed, others will continue well beyond the IPY. The IPY 2007-2008 represented a unique opportunity to further stimulate cooperation and coordination on Arctic health research and increase the awareness and visibility of Arctic regions.

Innovations for ISS Plug-In Plan (IPiP) Operations

NASA Technical Reports Server (NTRS)

Moore, Kevin D.

2013-01-01

Limited resources and increasing requirements will continue to influence decisions on ISS. The ISS Plug-In Plan (IPiP) supports power and data for utilization, systems, and daily operations through the Electrical Power System (EPS) Secondary Power/Data Subsystem. Given the fluid launch schedule, the focus of the Plug-In Plan has evolved to anticipate future requirements by judicious development and delivery of power supplies, power strips, Alternating Current (AC) power inverters, along with innovative deployment strategies. A partnership of ISS Program Office, Engineering Directorate, Mission Operations, and International Partners poses unique solutions with existing on-board equipment and resources.

POLAR-PALOOZA Polar Researchers and Arctic Residents Engage, Inform and Inspire Diverse Public Audiences by sharing Polar Science and Global Connections during the International Polar Year, using a New Model of Informal Science Education

NASA Astrophysics Data System (ADS)

Haines-Stiles, G.; Akuginow, E.

2006-12-01

(Please note that the POLAR-PALOOZA initiative described in this Abstract is-as of 9/7/2006-"pending" for possible support from NSF and NASA as part of this year's IPY solicitation. Subject to decisions expected by 9/30, this presentation would either be withdrawn, or amplified with specific participants, locations and dates.) Despite the success of well-regarded movies like "March of the Penguins", the polar regions remain a great unknown for most people. Public knowledge about the Arctic and Antarctic, and the critical role of the Poles in the entire Earth system, is nonexistent, incomplete or burdened with misperceptions. The International Polar Years of 2007-2009-and associated "I*Y" science years such as IHY, IYPE and eGY-present a unique opportunity to change this. The people who can best effect this change are those who know the Poles best, through living or working there. Based on innovative but proven models, POLAR-PALOOZA will use three complementary strategies to engage, inform and inspire large public audiences. (1) A national tour, under the working title "Stories from a Changing Planet", will include in-person presentations at science centers, museums, libraries and schools across North America, including Canada and Mexico. The presentations will be augmented by High Definition Video taped on location at the Poles, audio and video podcasts, and special education and outreach activities for targeted audiences. "Stories from a Changing Planet" will provide diverse audiences with an exciting opportunity to meet and interact directly with polar experts, and to appreciate why the Poles and the research done there are directly relevant to their lives. (2) The "HiDef Video Science Story Capture Corps" is a team of professional videographers, using the latest generation of low-cost, high-quality cameras, deployed to both Poles. They will document the work of multiple researchers and projects, rather than focusing on one topic for a single broadcast program. The resulting HD footage will be cataloged, archived and made available as public domain material, accessible to government research agencies for media releases, to the researchers and their home universities, and to science centers and museums. (3) POLAR- PALOOZA will edit short video and audio podcasts from this archive, and distribute them non-exclusively through an open network of websites, including iTunes, YouTube, Google, Yahoo, and the official IPY, US-IPY, NSF and NASA websites. Project design targets underserved groups and regions, and has developed a detailed strategy by which to reach out to under-served minorities and mid-sized and smaller communities over the entire two years of IPY. A balanced cadre of researchers, both male and female, young and old, ethnically-diverse and representing the many disciplines engaged in polar research, has already been identified, and over twenty five scientists, engineers, artists and journalists have committed to participating. The project's Advisors include members of the National Academy's Polar Research Board, and the two U.S. representatives to the international IPY Education and Outreach Committee.

Cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in the treatment of stage IE/IIE extranodal natural killer/T cell lymphoma, nasal type: 13-year follow-up in 135 patients.

PubMed

Wang, Liang; Xia, Zhong-jun; Huang, Hui-qiang; Lu, Yue; Zhang, Yu-jing

2012-11-01

We conducted a retrospective study of 135 patients of stage IE/IIE extranodal natural killer/T cell lymphoma, nasal type (ENKTL) treated with CHOP as induction chemotherapy to find some valuable prognostic factors and analyze the usefulness of International Prognostic Index (IPI) and Korean Prognostic Index (KPI) in predicting prognosis. Most of the patients were in the low-risk group (IPI score 0-1). Complete remission (CR) after induction chemotherapy was achieved in 31.8 % of the patients, which increased to 69.6 % after radiotherapy. The 2-, 5-, and 10-year overall survival (OS) rates were 60, 48, and 43 %, respectively. Patients with better performance status (ECOG 0-1), normal serum LDH level, without local invasiveness, low KPI scores, and IPI score of 0 had significantly better overall survival (P < 0.05) in univariate analysis. Using multivariate analysis, we identified serum LDH level, ECOG PS score and local invasiveness to be independent prognostic factors. In conclusion, ENKTL is an aggressive lymphoma that shows heterogeneity. The IPI and KPI score systems should be improved further to classify patients into different groups, and should be validated in larger prospective trials. Due to the multi-drug resistance mechanism of ENKTL, CHOP is no longer the state of art and novel drugs should be incorporated into future treatments.

Webuye Health and Demographic Surveillance Systems Baseline Survey of Soil-Transmitted Helminths and Intestinal Protozoa among Children up to Five Years

PubMed Central

Obala, A. A.; Simiyu, C. J.; Odhiambo, D. O.; Nanyu, V.; Chege, P.; Downing, R.; Mwaliko, E.; Mwangi, A. W.; Menya, D.; Chelagat, D.; Nyamogoba, H. D. N.; Ayuo, P. O.; O'Meara, W. P.; Twagirumukiza, M.; Vandenbroek, D.; Otsyula, B. B. O.; de Maeseneer, J.

2013-01-01

Background. The intestinal parasitic infections (IPIs) are globally endemic, and they constitute the greatest cause of illness and disease worldwide. Transmission of IPIs occurs as a result of inadequate sanitation, inaccessibility to potable water, and poor living conditions. Objectives. To determine a baseline prevalence of IPIs among children of five years and below at Webuye Health and Demographic Surveillance (HDSS) area in western Kenya. Methods. Cross-sectional survey was used to collect data. Direct saline and formal-ether-sedimentation techniques were used to process the specimens. Descriptive and inferential statistics such as Chi-square statistics were used to analyze the data. Results. A prevalence of 52.3% (417/797) was obtained with the male child slightly more infected than the female (53.5% versus 51%), but this was not significant (χ 2 = 0.482, P > 0.05). Giardia lamblia and Entamoeba histolytica were the most common pathogenic IPIs with a prevalence of 26.1% (208/797) and 11.2% (89/797), respectively. Soil-transmitted helminths (STHs) were less common with a prevalence of 4.8% (38/797), 3.8% (30/797), and 0.13% (1/797) for Ascaris lumbricoides, hookworms, and Trichuris trichiura, respectively. Conclusions. Giardia lamblia and E. histolytica were the most prevalent pathogenic intestinal protozoa, while STHs were less common. Community-based health promotion techniques are recommended for controlling these parasites. PMID:23533444

Functional Proteomic Analysis of Lipid Raft Kinase Complexes

DTIC Science & Technology

2009-08-01

Ribosomal protein SA Raft 12 46/300 + 16.0 8.0 2.0 18 8 2.3 14 6 2.3 712 + + IPI00023101 RQCD1 Homo sapiens protein involved in sexual development...KnownHuman 17-ODYA IPI00065486 ABCB6 CDNA FLJ32464 fis, clone SKNMC1000251, highly similar to Homo sapiens MT-ABCtransporter (MTABC) mRNA IPI00006675...3.7 : 0 + + IPI00023101 RQCD1 Homo sapiens protein involved in sexual development, complete cds + + IPI00021766 RTN4 Isoform 1 of Reticulon-4 12

Intestinal Parasitic Infections and Nutritional Status among Primary School Children in Delo-mena District, South Eastern Ethiopia.

PubMed

Tulu, Begna; Taye, Solomon; Zenebe, Yohannes; Amsalu, Eden

2016-01-01

Although there are efforts being underway to control and prevent intestinal parasitic infections (IPIs) in Ethiopia, they are still endemic and responsible for significant morbidity. The aim of this study was to evaluate the prevalence of IPIs and their association with nutritional status among primary school children of Delo-Mena district, South Eastern Ethiopia. A cross-sectional study was conducted from April to May 2013. Demographic data was obtained, and IPIs was investigated in a single-stool sample by both direct stool examination and formol-ether concentration techniques. Anthropometric measurements were taken to calculate height for-age (HAZ), BMI-for-age (BAZ) and weight-for-age (WAZ) for the determination of stunting, thinness and underweight, respectively using WHO AntroPlus software. SPSS version 20 was used for statistical analysis and p value less than 0.05 was considered significant. Among 492 children studied (51% boys, aged 6-18 years, mean 10.93 +2.4) an overall IPIs prevalence of 26.6% was found. The prevalence of S. mansoni , E. histolytica/dispar , H. nana , A. lumbricoides , G. lambilia , T. trichiura , S. stercolaris , E. vermicularis , Hookworms and Taenia spp were 9.6%, 7.7%, 5.3%, 3.7%, 2.0%, 1.6%, 1.4%, 1.2%, 0.8% and 0.2% respectively. Stunting and underweightedness were observed in 4.5% and 13.6% of children and associated with IPIs ( P <0.001) and ( P =0.001), respectively. IPIs and its associated malnutrition remain a public health concern in Delo-Mena district. Therefore, the overall health promotion activities coupled with snail control and de-worming to the students is crucial. Additionally, initiatives aimed at improving the nutritional status of school children are also important.

Fin whale tracks recorded by a seismic network on the Juan de Fuca Ridge, Northeast Pacific Ocean.

PubMed

Soule, Dax C; Wilcock, William S D

2013-03-01

Fin whale calls recorded from 2003 to 2004 by a seafloor seismic network on the Endeavour segment of the Juan de Fuca Ridge were analyzed to determine tracks and calling patterns. Over 150 tracks were obtained with a total duration of ~800 h and swimming speeds from 1 to 12 km/h. The dominant inter-pulse interval (IPI) is 24 s and the IPI patterns define 4 categories: a 25 s single IPI and 24/30 s dual IPI produced by single calling whales, a 24/13 s dual IPI interpreted as two calling whales, and an irregular IPI interpreted as groups of calling whales. There are also tracks in which the IPI switches between categories. Call rates vary seasonally with all the tracks between August and April. From August to October tracks are dominated by the irregular IPI and are predominantly headed to the northwest, suggesting that a portion of the fin whale population does not migrate south in the fall. The other IPI categories occur primarily from November to March. These tracks have slower swimming speeds, tend to meander, and are predominantly to the south. The distribution of fin whales around the network is non-random with more calls near the network and to the east and north.

Status of intestinal parasitic infections among residents of Jimma Town, Ethiopia.

PubMed

Jejaw, Ayalew; Zeynudin, Ahmed; Zemene, Endalew; Belay, Tariku

2014-08-07

Intestinal parasites cause considerable morbidity and mortality in the world, especially in developing countries like Ethiopia. Both urban and rural inhabitants are vulnerable to infection with intestinal parasites in developing countries. The aim of this study was to determine the status of intestinal parasitic infections (IPIs) among residents of Jimma Town, seven years after high prevalence was reported. Four hundred and thirty four residents of Jimma Town were included in this study. By the cross-sectional survey, the overall prevalence of intestinal parasites was 209 (48.2%). Nine species of intestinal parasites were isolated, Ascaris lumbricoides and Trichuris trichiura being the most predominant. Residence in Hermata Mentina kebele, Adjusted Odds Ratio (AOR), 3.0, 95% CI, 1.71-5.39), age less than 10 years (AOR, 3.7, 95% CI, 1.33-10.36), illiteracy (AOR, 3.2, 95% CI, 1.64-6.19), estimated monthly family income of less than 500 Ethiopian Birr (AOR, 2.9, 95% CI, 1.32-4.90) and irregular washing hands before meal (AOR, 5.3, 95% CI, 1.36-21.07) were predictors of IPI in this study. The retrospective study revealed a significant decrease (P = 0.037) in the proportion of patients infected with intestinal parasites out of those who requested stool examination over the six-year period. This study confirms that IPIs are still common among residents of Jimma Town. Nearly half of the study participants were infected with at least one intestinal parasite. Public health interventions targeting prevention of IPIs should be strengthened in Jimma Town.

Data Management Considerations for the International Polar Year

NASA Astrophysics Data System (ADS)

Parsons, M. A.; Weaver, R. L.; Duerr, R.; Barry, R. G.

2004-12-01

The legacy of the International Geophysical Year and past International Polar Years is in the scientific data collected. The upcoming IPY will result in an unprecedented collection of geophysical and social science data from the polar regions. To realize the full scientific and interdisciplinary utility of these data it is essential to consider the design of data management systems early in the expirimental planning process. This paper will present an array of high level data management considerations for the IPY including cross-disciplinary data access, essential documentation, system guidance, and long-term data archiving. Specific recommendations from relevant international organizations such as the Joint Committee on Antarctic Data Management and the WCRP Climate and Cryosphere Programme will be considered. The potential role of the Electronic Geophysical Year and other International Years will also be discussed.

The International Polar year 2007-2008; the Arctic human health legacy.

PubMed

Parkinson, Alan J

2007-01-01

Life expectancy in Arctic populations has greatly improved over the last 50 years. Much of this improvement can be attributed health research that has resulted in a reduction in morbidity and mortality from infectious diseases, such as tuberculosis, and the vaccine-preventable diseases of childhood. However, despite these improvements in health indicators of Arctic residents, life expectancy and infant mortality remain higher in indigenous Arctic residents in the US Arctic, northern Canada, and Greenland when compared to Arctic residents of Nordic countries. The International Polar Year (IPY) represents a unique opportunity to focus world attention on Arctic human health and to further stimulate Circumpolar cooperation on emerging Arctic human health concerns. The Arctic Human Health Initiative (AHHI) is an Arctic Council IPY initiative that aims to build and expand on existing Arctic Council and International Union for Circumpolar Health (IUCH) human health research activities. The human health legacy of the IPY will be increased visibility of the human health concerns of Arctic communities, revitalization of cooperative Arctic human health research focused on those concerns, the development of health policies based on research findings, and the subsequent implementation of appropriate interventions, prevention and control measures at the community level.

Spatial and temporal trends in fin whale vocalizations recorded in the NE Pacific Ocean between 2003-2013

PubMed Central

Weirathmueller, Michelle J.; Stafford, Kathleen M.; Wilcock, William S. D.; Hilmo, Rose S.; Dziak, Robert P.; Tréhu, Anne M.

2017-01-01

In order to study the long-term stability of fin whale (Balaenoptera physalus) singing behavior, the frequency and inter-pulse interval of fin whale 20 Hz vocalizations were observed over 10 years from 2003–2013 from bottom mounted hydrophones and seismometers in the northeast Pacific Ocean. The instrument locations extended from 40°N to 48°N and 130°W to 125°W with water depths ranging from 1500–4000 m. The inter-pulse interval (IPI) of fin whale song sequences was observed to increase at a rate of 0.54 seconds/year over the decade of observation. During the same time period, peak frequency decreased at a rate of 0.17 Hz/year. Two primary call patterns were observed. During the earlier years, the more commonly observed pattern had a single frequency and single IPI. In later years, a doublet pattern emerged, with two dominant frequencies and IPIs. Many call sequences in the intervening years appeared to represent a transitional state between the two patterns. The overall trend was consistent across the entire geographical span, although some regional differences exist. Understanding changes in acoustic behavior over long time periods is needed to help establish whether acoustic characteristics can be used to help determine population identity in a widely distributed, difficult to study species such as the fin whale. PMID:29073230

Spatial and temporal trends in fin whale vocalizations recorded in the NE Pacific Ocean between 2003-2013.

PubMed

Weirathmueller, Michelle J; Stafford, Kathleen M; Wilcock, William S D; Hilmo, Rose S; Dziak, Robert P; Tréhu, Anne M

2017-01-01

In order to study the long-term stability of fin whale (Balaenoptera physalus) singing behavior, the frequency and inter-pulse interval of fin whale 20 Hz vocalizations were observed over 10 years from 2003-2013 from bottom mounted hydrophones and seismometers in the northeast Pacific Ocean. The instrument locations extended from 40°N to 48°N and 130°W to 125°W with water depths ranging from 1500-4000 m. The inter-pulse interval (IPI) of fin whale song sequences was observed to increase at a rate of 0.54 seconds/year over the decade of observation. During the same time period, peak frequency decreased at a rate of 0.17 Hz/year. Two primary call patterns were observed. During the earlier years, the more commonly observed pattern had a single frequency and single IPI. In later years, a doublet pattern emerged, with two dominant frequencies and IPIs. Many call sequences in the intervening years appeared to represent a transitional state between the two patterns. The overall trend was consistent across the entire geographical span, although some regional differences exist. Understanding changes in acoustic behavior over long time periods is needed to help establish whether acoustic characteristics can be used to help determine population identity in a widely distributed, difficult to study species such as the fin whale.

Antarctic Data Management as Part of the IPY Legacy

NASA Astrophysics Data System (ADS)

de Bruin, T.

2006-12-01

The Antarctic Treaty states that "scientific observations and results from Antarctica shall be exchanged and made freely available". Antarctica includes the Southern Ocean. In support of this, National Antarctic Data Centres (NADC) are being established to catalogue data sets and to provide information on data sets to scientists and others with interest in Antarctic science. The Joint Committee on Antarctic Data Management (JCADM) was established by the Scientific Committee on Antarctic Research (SCAR) and the Council of Managers of National Antarctic Programs (COMNAP). JCADM comprises representatives of the National Antarctic Data Centres. Currently 30 nations around the world are represented in JCADM. JCADM is responsible for the Antarctic Master Directory (AMD), the internationally accessible, web-based, searchable record of Antarctic and Southern Ocean data set descriptions. The AMD is directly integrated into the international Global Change Master Directory (GCMD) to help further merge Antarctic science into global science. The AMD is a resource for scientists to advertise the data they have collected and to search for data they may need. JCADM is the Antarctic component of the IPY Data Infrastructure, which is presently being developed. This presentation will give an overview of the organization of Antarctic and Southern Ocean data management with sections on the organizational structure of JCADM, contents of the Antarctic Master Directory, relationships to the SCAR Scientific Research Programmes (SRP) and IPY, international embedding and connections with discipline-based peer organizations like the International Oceanographic Data and Information Exchange Committee (IODE). It will focus primarily on the role that an existing infrastructure as JCADM, may play in the development of the IPY Data Infrastructure and will provide considerations for IPY data management, based on the experiences in Antarctic and oceanographic data management.

The Impact of Computing Interpregnancy Intervals Without Accounting for Intervening Pregnancy Events.

PubMed

Conzuelo-Rodriguez, Gabriel; Naimi, Ashley I

2018-03-01

Short interpregnancy intervals (IPI) are associated with poor birth outcomes. Often, only livebirths are considered to estimate IPI. The objective of our work is to explore whether the associations between demographic, behavioural, and pregnancy variables and IPI change when events other than livebirth are included. We used data from the 2006-10 and 2011-13 period of the National Survey of Family Growth (NSFG). We defined IPI using the conception date of the index pregnancy and the event date of the previous one ending in (i) livebirth; (ii) stillbirth; (iii) miscarriage; (iv) abortion; or (v) any of these events. Risk ratios (RR) were estimated for short IPI (<18 months), and demographic, pregnancy, and behavioural variables using log-linear models. When intervening events are included, the association between short IPI and its predictors vary by definition, especially for unintended versus intended pregnancies (only livebirth risk ratio [RR] 1.34, 95% confidence interval [CI] 1.2, 1.5) versus livebirth and miscarriage RR 1.14, 95% CI 1.0, 1.3) and women older than 30 vs. younger than 20 at resolution of the previous pregnancy (only livebirth RR 1.22, 95% CI 1.0, 1.5 versus livebirth and miscarriage RR 1.36, 95% CI 1.2, 1.6). Including miscarriage as an intervening event in the calculation of IPI changes the association between several risk factors and short IPI. However, the association between short IPI and preterm birth does not vary when different IPI calculations are used. © 2018 John Wiley & Sons Ltd.

PolarTREC-Teachers and Researchers Exploring and Collaborating: Science Education from the Poles to the World

NASA Astrophysics Data System (ADS)

Timm, K. M.; Warburton, J.; Owens, R.; Warnick, W. K.

2008-12-01

PolarTREC--Teachers and Researchers Exploring and Collaborating, a program of the Arctic Research Consortium of the U.S. (ARCUS), is a National Science Foundation (NSF)--funded International Polar Year (IPY) project in which K-12 educators participate in hands-on field experiences, working closely with IPY scientists as a pathway to improving science education. PolarTREC has developed a successful internet-based platform for teachers and researchers to interact and share their diverse experiences and expertise by creating interdisciplinary educational tools including online journals and forums, real-time Internet seminars, lesson plans, activities, audio, and other educational resources that address a broad range of scientific topics. These highly relevant, adaptable, and accessible resources are available to educators across the globe and have connected thousands of students and citizens to the excitement of polar science. By fostering the integration of research and education and infusing education with the thrill of discovery, PolarTREC will produce a legacy of long-term teacher-researcher collaborations and increased student knowledge of and interest in the polar regions well beyond the IPY time period. Educator and student feedback from preliminary evaluations has shown that PolarTREC's comprehensive program activities have many positive impacts on educators and their ability to teach science concepts and improve their teaching methods. Additionally, K-12 students polled in interest surveys showed significant changes in key areas including amount of time spent in school exploring research activities, importance of understanding science for future work, importance of understanding the polar regions as a person in today's world, as well as increased self-reported knowledge and interest in Science, Technology, Engineering, and Mathematics content areas. PolarTREC provides a tested approach and a clear route for researcher participation in the education community, facilitating increased educator, student, and community understanding of science and the polar regions during times of interrelated global change. For more information, visit the PolarTREC website.

Interpregnancy interval as a risk factor for postmenopausal osteoporosis.

PubMed

Sahin Ersoy, Gulcin; Giray, Burak; Subas, Seda; Simsek, Ersin; Sakin, Onder; Turhan, Omer Talip; Bulut, Sadullah

2015-10-01

Bone mass loss associated with pregnancy and lactation is usually regained in the postpartum period. However, it is not known whether the bone loss is completely recovered in women with a shortened interpregnancy interval (IPI). The aim of this study was to analyze the effect of IPI and gynecological history on postmenopausal osteoporosis. The study was conducted among 537 postmenopausal women who were divided into two groups in accordance with the osteoporosis status. Prior to bone densitometry, the patients were questioned about reproductive history. Dual-energy X-ray absorptiometry was used to measure lumbar spinal, femur neck and total femoral bone mineral density. Association between IPI and postmenopausal osteoporosis was analyzed. The comparison of both groups according to the total duration of breastfeeding did not reveal a considerable variation (p=0.288). In the osteoporosis group the age and duration of menopause were found to be significantly higher (p<0.001) whereas the age of first pregnancy and IPI were notably lower in comparison to the controls group (p<0.001). Multivariate logistic regression analyses revealed that women who have 0-12 months interpregnancy interval have the highest risk for osteoporosis (OR: 4.306; 95% CI, 1.684-11.01). This analysis confirmed that the occurrence of first pregnancy under 27 years of age conveyed a higher risk for osteoporosis, as well. Shortened IPI may have a detrimental effect on bone mineral density in postmenopausal age. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

A Rising Tide for Polar Science: Efforts of the U.S. National Committee for the International Polar Year

NASA Astrophysics Data System (ADS)

Albert, M. R.

2003-12-01

The polar regions, fascinating yet distant and cold places, hold the keys to our changing world. While the upcoming IPY is the 50th anniversary of the International Geophysical Year and the 125th anniversary of the first International Polar Year, it also falls at a crucial time in rapid changes in environmental and social systems that may affect all peoples of the Earth. Further warming of the Arctic, changing ecosystems and opening pathways for ocean travel, impact not only the people there but also the shipping, economics, and strategic considerations of distant nations. Yet potential further warming of the Arctic may be understood by clues in the Antarctic ice. How are the polar regions changing, and how swiftly may those changes affect the entire Earth? This is but one question emerging from community discussions of the science of the upcoming IPY. Our emerging ability to investigate previously unexplored areas is increasing our understanding of the wide world we live in, through interdisciplinary studies and tools for connections. Autonomous vehicles, genomics, and remote sensing technologies are just a few of the emerging areas that may provide new tools for investigating previously inaccessible realms. At the same time, tools such as the internet are making the world smaller, enabling instant communications between the peoples of the world. Joint international investigations enhance our ability to understand one another as well as our ability to understand our world and our universe. Rapid communications and international involvement can revolutionize the way we educate young scientists and our future leaders in a complex and changing world. Involving and educating people - young scientists, college students, school children, and the public - will be included as hallmarks of the IPY. The people are here. New tools are emerging. The ideas, or scientific goals, of the IPY are being crafted jointly through broad involvement of the scientific community, through meetings, conversations, and web-based discussions. This presentation will describe the process that the U.S. National committee has employed to nurture the evolution of the IPY, and will describe the new report that is being prepared based on this process.

Landsat Image Mosaic of Antarctica (LIMA)

USGS Publications Warehouse

,

2007-01-01

For most of us, Antarctica was at best a distant acquaintance. Now, with the Landsat Image Mosaic of Antarctica (LIMA), we are on intimate terms. In stunning, up-close and personal detail, LIMA brings Antarctica to life. Explore this virtually cloudless, seamless, most geometrically accurate, and highest resolution satellite mosaic of Antarctica. A team of scientists from the U.S. Geological Survey, the British Antarctic Survey, and the National Aeronautics and Space Administration, with funding from the National Science Foundation, created LIMA in support of the International Polar Year (IPY; 2007?08). As the first major scientific outcome of the IPY, LIMA truly fulfills the IPY goals. LIMA is an international effort, supports current scientific polar research, encourages new projects, and helps the general public visualize Antarctica and changes happening in this southernmost environment. Researchers and the general public can download LIMA and all component Landsat scenes at no charge.

Bring the Poles to Your Classroom & Community Through Linked Hands-on Learning & IPY Data

NASA Astrophysics Data System (ADS)

Turrin, M.; Bell, R. E.; Kastens, K. A.; Pfirman, S. L.

2009-12-01

Two major legacies of the 4th International Polar Year (IPY 2007-9) are a newly galvanized educational community and an immense volume of polar data collected by the global science community. The tremendous new polar datasets represent a unique opportunity to communicate the nature of the changing poles to student and public audiences through this polar savvy educational community if effective approaches to link data and understanding are employed. We have developed a strategy for polar education that leverages the IPY data resources, linked with the polar education hands-on ‘manipulatives’ (materials that students can manipulate in a dynamic manner). This linked approach leverages the fundamental inquiry based learning but recognizes that particularly in the polar sciences the size of the earth, the remoteness of the poles and the scale of its processes make it difficult for students to explore in a hands-on manner. The linking of polar hands-on ‘manipulatives’ with IPY data provides a bridge between the tangible and the global. Alone manipulative activities can be beneficial in their ability to help students visualize a process or behavior, but without a strong link back to the Earth through data or evidence the understanding of the process is not transferred from the classroom model to the full scale Earth. The use of activities or models is beneficial in connecting the learner to the polar process(es), while the IPY data provides a unique opportunity to ground the polar manipulative experiments in real data. This linked strategy emerged from a series of NSF sponsored IPY Polar Fairs at major science museums that reached in excess of 12,000 people. The design of the fairs was that polar scientists developed activities linking low cost hands-on manipulatives to scientific evidence/data that was displayed in posters, images, and video clips. The participating scientists walked the ‘audience’ through the hands-on manipulative, then discussed their evidence while provided the reasoning. Adjusting this linked manipulative/data approach to the community of teachers will provide a very tangible education outcome to this community from IPY. Our linked manipulative-data strategy ensures polar processes are demonstrated, measured then matched with IPY data sets so that when examined in a guided exploration will provide the student the tools to generate the reasoning. This linked strategy is a powerful way to engage students in Earth science, and provide them with an entry to the wealth of professionally collected data sets that are available from both IPY and the broader science community, all while aligning with National Science Standards. We will demonstrate this approach, and show how the linked manipulative-data approach can be effectively used in community and school events to reach a wider audience.

PolarTREC: Successful Methods and Tools for Attaining Broad Educational Impacts with Interdisciplinary Polar Science

NASA Astrophysics Data System (ADS)

Timm, K. M.; Warburton, J.; Owens, R.; Warnick, W. K.

2008-12-01

PolarTREC--Teachers and Researchers Exploring and Collaborating, a program of the Arctic Research Consortium of the U.S. (ARCUS), is a National Science Foundation (NSF)-funded International Polar Year (IPY) project in which K-12 educators participate in hands-on field experiences in the polar regions, working closely with IPY scientists as a pathway to improving science education. Developing long-term teacher- researcher collaborations through PolarTREC ensures up-to-date climate change science content will permeate the K-12 education system long after the IPY. By infusing education with the cutting edge science from the polar regions, PolarTREC has already shown an increase in student and public knowledge of and interest in the polar regions and global climate change. Preliminary evaluations have shown that PolarTREC's program activities have many positive impacts on educators and their ability to teach science concepts and improve their teaching methods. Additionally, K-12 students polled in interest surveys showed significant changes regarding the importance of understanding the polar regions as a person in today's world. Researchers have been overwhelmingly satisfied with PolarTREC and cited several specific strengths, including the program's crucial link between the teachers' field research experiences and their classroom and the extensive training provided to teachers prior to their expedition. This presentation will focus on other successful components of the PolarTREC program and how researchers and organizations might use these tools to reach out to the public for long-term impacts. Best practices include strategies for working with educators and the development of an internet-based platform for teachers and researchers to interact with the public, combining several communication tools such as online journals and forums, real-time Internet seminars, lesson plans, activities, audio, and other educational resources that address a broad range of scientific topics. These highly relevant, adaptable, and accessible tools and resources are available to educators across the globe and have connected thousands of students and citizens to the excitement of polar science. PolarTREC provides a tested approach and a clear route for researcher participation in the education community, facilitating increased educator, student, and community understanding of science and the polar regions during times of interrelated global change. For more information, visit the PolarTREC website.

PolarTREC: Successful Methods and Tools for Attaining Broad Educational Impacts with Interdisciplinary Polar Science

NASA Astrophysics Data System (ADS)

Warburton, J.; Timm, K. M.; Owens, R.; Warnick, W. K.

2008-12-01

PolarTREC--Teachers and Researchers Exploring and Collaborating, a program of the Arctic Research Consortium of the U.S. (ARCUS), is a National Science Foundation (NSF)-funded International Polar Year (IPY) project in which K-12 educators participate in hands-on field experiences in the polar regions, working closely with IPY scientists as a pathway to improving science education. Developing long-term teacher- researcher collaborations through PolarTREC ensures up-to-date climate change science content will permeate the K-12 education system long after the IPY. By infusing education with the cutting edge science from the polar regions, PolarTREC has already shown an increase in student and public knowledge of and interest in the polar regions and global climate change. Preliminary evaluations have shown that PolarTREC's program activities have many positive impacts on educators and their ability to teach science concepts and improve their teaching methods. Additionally, K-12 students polled in interest surveys showed significant changes regarding the importance of understanding the polar regions as a person in today's world. Researchers have been overwhelmingly satisfied with PolarTREC and cited several specific strengths, including the program's crucial link between the teachers' field research experiences and their classroom and the extensive training provided to teachers prior to their expedition. This poster will focus on other successful components of the PolarTREC program and how researchers and organizations might use these tools to reach out to the public for long-term impacts. Best practices include strategies for working with educators and the development of an internet-based platform for teachers and researchers to interact with the public, combining several communication tools such as online journals and forums, real-time Internet seminars, lesson plans, activities, audio, and other educational resources that address a broad range of scientific topics. These highly relevant, adaptable, and accessible tools and resources are available to educators across the globe and have connected thousands of students and citizens to the excitement of polar science. PolarTREC provides a tested approach and a clear route for researcher participation in the education community, facilitating increased educator, student, and community understanding of science and the polar regions during times of interrelated global change. For more information, visit the PolarTREC website.

Neglected Intestinal Parasites, Malnutrition and Associated Key Factors: A Population Based Cross-Sectional Study among Indigenous Communities in Sarawak, Malaysia.

PubMed

Rajoo, Yamuna; Ambu, Stephen; Lim, Yvonne Ai Lian; Rajoo, Komalaveni; Tey, Siew Chang; Lu, Chan Woon; Ngui, Romano

2017-01-01

Intestinal parasitic infections (IPIs) have been recognized as one of the most significant causes of illness among disadvantaged communities. Many studies have been conducted on the prevalence of IPIs in Malaysia. However, these studies mostly focused on the indigenous groups in Peninsular Malaysia. The present study was conducted to provide the current baseline data on prevalence of IPIs, anaemia, malnutrition and associated risk factors among the indigenous communities in Sarawak, situation at northwest Borneo island of Malaysia. A cross sectional study was conducted among the longhouses communities. Stool samples were obtained and examined for the presence of IPIs using microscopy technique. Haemoglobin measurement was done using a portable haemoglobin analyzer. Malnutrition (i.e., stunting, underweight and wasting) was assessed using the WHO Anthro software. Statistical analysis was carried out using SPSS software. A total of 341participants took part in this study. The overall prevalence of IPIs was 57.5%. Multivariate analysis indicated that the absence of toilets (OR = 1.6; 95% CI = 1.1-2.7; p = 0.002) and close contact with animals (OR = 1.8; 95% CI = 1.3-2.9; p = 0.027) as significant predictors for IPIs. The incidence of anaemia was 36.4%. The incidence of underweight, wasting and stunting were 22.2%, 5.6% and 35.4%, respectively. Multivariate analysis demonstrated that low level of parental education attainment (OR = 1.9; 95% CI = 1.2-3.0; p = 0.006) was identified as significant predictor for anaemia. The incidence of wasting was significantly associated with mild anaemia (OR = 1.2; 95% CI = 0.9-1.7; p = 0.024). Low household income was identified as significant predictor for stunting (OR = 2.1; 95% CI = 9.8-22.2; p = 0.001) and underweight (OR = 1.9; 95% CI = 5.6-18.7; p = 0.037), respectively. Essentially, the present study highlighted that intestinal parasitic infections, anaemia and malnutrition are still prevalent among rural indigenous community in Sarawak. Improvement of socioeconomic status, periodic mass deworming, iron supplementation and health education program should be included in the control and prevention of public health strategies.

Integration of Science and Outreach: Setting New Precedents during IPY

NASA Astrophysics Data System (ADS)

Salmon, R. A.; Munro, N.; Carlson, D.; Pauls, M.; Zicus, S.

2008-12-01

IPY has been a phenomenal opportunity for scientists to engage in exciting research as part of a large interdisciplinary and international effort. It has also been an opportunity to share this research with the public, and demonstrate how individual projects fit into a much larger picture. Through international and interdisciplinary cooperation, IPY has catalysed thousands of local initiatives that have collectively had a global impact. Teachers, artists, journalists, parents, scientists, policy makers, polar visitors, film-makers, book readers and internet enthusiasts from around the world have become excited by polar research as a result of IPY. Coordinated IPY events during this time have engaged these new enthusiasts and catalysed a range of local activities that focus on polar research. These activities, often involving international dialogue, occur concurrently and thus help each participant feel they are part of a greater global event, much like the structure of IPY. The overall impact has therefore been to raise awareness of polar issues and research globally. This talk will present some of the achievements and highlights of IPY Education, Outreach and Communication that have occurred on a local, national, and international scale.

An Introduction to Fortran Programming: An IPI Approach.

ERIC Educational Resources Information Center

Fisher, D. D.; And Others

This text is designed to give individually paced instruction in Fortran Programing. The text contains fifteen units. Unit titles include: Flowcharts, Input and Output, Loops, and Debugging. Also included is an extensive set of appendices. These were designed to contain a great deal of practical information necessary to the course. These appendices…

Identification, Characterization, and Utilization of Adult Meniscal Progenitor Cells

DTIC Science & Technology

2014-09-01

SMURF2 IPI00329664 30,9 7,9 16,2 3,7 COL1A1 IPI00304962 409,2 83,5 398,4 22,0 ACAN IPI00027377 86,7 54,6 100,7 25,8 COL6A2 IPI00983601 28,5 6,4 34,4...GGGTTCAGAGTGTTGTACAGTCC-30 NM_003239.2 RUNX2 50-TTCCAGACCAGCAGCACTC-30 50-CAGCGTCAACACCATCATT-30 NM_004348 COL1A1 50-TTCCCCCAGCCACAAAGAGTC-30 50

Enhancing patient understanding of medical procedures: evaluation of an interactive multimedia program with in-line exercises.

PubMed

Tait, Alan R; Voepel-Lewis, Terri; Chetcuti, Stanley J; Brennan-Martinez, Colleen; Levine, Robert

2014-05-01

Standard print and verbal information provided to patients undergoing treatments are often difficult to understand and may impair their ability to be truly informed. This study examined the effect of an interactive multimedia informational program with in-line exercises and corrected feedback on patients' real-time understanding of their cardiac catheterization procedure. 151 adult patients scheduled for diagnostic cardiac catheterization were randomized to receive information about their procedure using either the standard institutional verbal and written information (SI) or an interactive iPad-based informational program (IPI). Subject understanding was evaluated using semi-structured interviews at baseline, immediately following catheterization, and 2 weeks after the procedure. In addition, for those randomized to the IPI, the ability to respond correctly to several in-line exercises was recorded. Subjects' perceptions of, and preferences for the information delivery were also elicited. Subjects randomized to the IPI program had significantly better understanding following the intervention compared with those randomized to the SI group (8.3±2.4 vs 7.4±2.5, respectively, 0-12 scale where 12=complete understanding, P<0.05). First-time correct responses to the in-line exercises ranged from 24.3% to 100%. Subjects reported that the in-line exercises were very helpful (9.1±1.7, 0-10 scale, where 10=extremely helpful) and the iPad program very easy to use (9.0±1.6, 0-10 scale, where 10=extremely easy) suggesting good clinical utility. Results demonstrated the ability of an interactive multimedia program to enhance patients' understanding of their medical procedure. Importantly, the incorporation of in-line exercises permitted identification of knowledge deficits, provided corrected feedback, and confirmed the patients' understanding of treatment information in real-time when consent was sought. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Peripheral T-cell lymphoma, not otherwise specified: a report of 340 cases from the International Peripheral T-cell Lymphoma Project.

PubMed

Weisenburger, Dennis D; Savage, Kerry J; Harris, Nancy Lee; Gascoyne, Randy D; Jaffe, Elaine S; MacLennan, Kenneth A; Rüdiger, Thomas; Pileri, Stefano; Nakamura, Shigeo; Nathwani, Bharat; Campo, Elias; Berger, Francoise; Coiffier, Bertrand; Kim, Won-Seog; Holte, Harald; Federico, Massimo; Au, Wing Y; Tobinai, Kensei; Armitage, James O; Vose, Julie M

2011-03-24

The International Peripheral T-cell Lymphoma Project is a collaborative effort to better understand peripheral T-cell lymphoma (PTCL). A total of 22 institutions submitted clinical and pathologic material on 1314 cases. One objective was to analyze the clinical and pathologic features of 340 cases of PTCL, not otherwise specified. The median age of the patients was 60 years, and the majority (69%) presented with advanced stage disease. Most patients (87%) presented with nodal disease, but extranodal disease was present in 62%. The 5-year overall survival was 32%, and the 5-year failure-free survival was only 20%. The majority of patients (80%) were treated with combination chemotherapy that included an anthracycline, but there was no survival advantage. The International Prognostic Index (IPI) was predictive of both overall survival and failure-free survival (P < .001). Multivariate analysis of clinical and pathologic prognostic factors, respectively, when controlling for the IPI, identified bulky disease (≥ 10 cm), thrombocytopenia (< 150 × 10(9)/L), and a high number of transformed tumor cells (> 70%) as adverse predictors of survival, but only the latter was significant in final analysis. Thus, the IPI and a single pathologic feature could be used to stratify patients with PTCL-not otherwise specified for novel and risk-adapted therapies.

ICESTAR - An IHY/IPY study of interhemispheric relationships in space physics

NASA Astrophysics Data System (ADS)

Donovan, E.; Kauristi, K.; Harrison, R.; Stamper, R.; Weatherwax, A.; Papitashvili, V.

2006-05-01

ICESTAR (Interhemispheric Conjugacy Effects in Solar-Terrestrial and Aeronomy Research) is a programme coordinating multinational research on Sun-Earth connections. ICESTAR concentrates on magnetospheric and upper atmospheric responses to solar inputs, with a particular focus on inter-hemispheric relationships. Key aspects of our approach include the networking of ground-based instruments, the closely related issue of fostering international collboration, and open web-based access to the relevant data. To accomplish the latter, we are involved in the development of virtual observatories and are adhering to the overarching philosophies of the IHY and eGY. IHY and ICESTAR have submitted a proposal for a core project status to the Joint Committee of the International Polar Year (IPY). This initiative, "ICESTAR/IHY - Interhemispheric Conjugacy in Geospace Phenomena and their Heliospheric Drivers", includes 24 research groups from more than twenty countries. Harvesting the unique opportunities of IPY in a timely fashion will be challenging. In addition to far- reaching interdisciplinary scientific work IPY is looking forward to exciting new education and outreach activities and efficient utilization of the latest advancements in computer and communications technology. Preparatory work to meet these ambitious objectives has already started within the ICESTAR/IHY community. In the presentation we outline our scientific goals and implementation plan, our progress to date, and describe activities to facilitate cooperative research.

Multiplex polymerase chain reaction-based prognostic models in diffuse large B-cell lymphoma patients treated with R-CHOP.

PubMed

Green, Tina M; Jensen, Andreas K; Holst, René; Falgreen, Steffen; Bøgsted, Martin; de Stricker, Karin; Plesner, Torben; Mourits-Andersen, Torben; Frederiksen, Mikael; Johnsen, Hans E; Pedersen, Lars M; Møller, Michael B

2016-09-01

We present a multiplex analysis for genes known to have prognostic value in an attempt to design a clinically useful classification model in patients with diffuse large B-cell lymphoma (DLBCL). Real-time polymerase chain reaction was used to measure transcript levels of 28 relevant genes in 194 de novo DLBCL patients treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone). Including International Prognostic Index (IPI) as a variable in a penalized Cox regression, we investigated the association with disease progression for single genes or gene combinations in four models. The best model was validated in data from an online available R-CHOP treated cohort. With progression-free survival (PFS) as primary endpoint, the best performing IPI independent model incorporated the LMO2 and HLADQA1 as well as gene interactions for GCSAMxMIB1, GCSAMxCTGF and FOXP1xPDE4B. This model assigned 33% of patients (n = 60) to poor outcome with an estimated 3-year PFS of 40% vs. 87% for low risk (n = 61) and intermediate (n = 60) risk groups (P < 0·001). However, a simpler, IPI independent model incorporated LMO2 and BCL2 and assigned 33% of the patients with a 3-year PFS of 35% vs. 82% for low risk group (P < 0·001). We have documented the impact of a few single genes added to IPI for assignment in new drug trials. © 2016 John Wiley & Sons Ltd.

The role of family size, employment and education of parents in the prevalence of intestinal parasitic infections in school children in Accra.

PubMed

Forson, Akua Obeng; Arthur, Isaac; Ayeh-Kumi, Patrick F

2018-01-01

Intestinal parasitic infections (IPIs) in school children are a public health problem in most developing countries. A cross sectional survey was conducted from May to July 2016 with school children living in overcrowded urban slums in Accra, Ghana. A simple random sample of 300 children aged 2-9 years was collected. The study used structured pre-tested questionnaire and stool tests to obtain information on epidemiological, sanitation habits, employment and education status of parents and children. Data were analysed using appropriate descriptive, univariate and multivariable logistic tools of analyses. The mean age of participants was 6.9 years and 49% were males and 51.3% were females. Giardia lamblia was found in males (10.95%) and females (7.79%). Very low prevalences for Schistosoma mansoni, Ascaris lumbricoides, Taenia species, and Entamoeba coli were detected. Whilst children from mothers (62.2%) and fathers (55.6%) with no education were often infected, a few children from fathers (22.2%) and mothers (6.7%) with no jobs were infected. Most of the infected children's (93.7%) parents did not have any knowledge of IPIs. The educational and employment status of the mothers [p = 1.0 and p = 0.422] was not significant, however, the family size was a predisposing factor (p = 0.031) for parasitic infections. Intestinal parasites were prevalent in children from overcrowded families and with no knowledge of IPIs. Educative programmes on IPIs, improving hygiene, and application of supportive programmes to elevate socioeconomic conditions may help reduce the burden of intestinal parasite carriage in children.

Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors

PubMed Central

Jimeno, Antonio; Weiss, Glen J.; Miller, Wilson H.; Gettinger, Scott; Eigl, Bernard J.C.; Chang, Anne Lynne S.; Dunbar, Joi; Devens, Shannon; Faia, Kerrie; Skliris, Georgios; Kutok, Jeff; Lewis, Karl D.; Tibes, Raoul; Sharfman, William H.; Ross, Robert W.; Rudin, Charles M.

2013-01-01

Purpose To conduct a first-in-human phase I study to determine the dose-limiting toxicities (DLT), characterize the pharmacokinetic profile, and document the antitumor activity of IPI-926, a new chemical entity that inhibits the Hedgehog pathway (HhP). Experimental Design Patients with solid tumors refractory to standard therapy were given IPI-926 once daily (QD) by mouth in 28-day cycles. The starting dose was 20 mg, and an accelerated titration schedule was used until standard 3 + 3 dose-escalation cohorts were implemented. Pharmacokinetics were evaluated on day −7 and day 22 of cycle 1. Results Ninety-four patients (32F, 62M; ages, 39–87) received doses ranging from 20 to 210 mg QD. Dose levels up to and including 160 mg administered QD were well tolerated. Toxicities consisted of reversible elevations in aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin, fatigue, nausea, alopecia, and muscle spasms. IPI-926 was not associated with hematologic toxicity. IPI-926 pharmacokinetics were characterized by a slow absorption (Tmax = 2–8 hours) and a terminal half-life (t1/2) between 20 and 40 hours, supporting QD dosing. Of those HhP inhibitor-naïve patients with basal cell carcinoma (BCC) who received more than one dose of IPI-926 and had a follow-up clinical or Response Evaluation Criteria in Solid Tumors (RECIST) assessment, nearly a third (8 of 28 patients) showed a response to IPI-926 at doses ≥130 mg. Conclusions IPI-926 was well tolerated up to 160 mg QD within 28-day cycles, which was established as the recommended phase II dose and schedule for this agent. Single-agent activity of IPI-926 was observed in HhP inhibitor–naïve patients with BCC. PMID:23575478

Multicenter Phase 2 Trial of the Hsp-90 Inhibitor, IPI-504 (retaspimycin hydrochloride), in Patients with Castration-Resistant Prostate Cancer

PubMed Central

Oh, William K; Galsky, Matthew D.; Stadler, Walter M.; Srinivas, Sandy; Chu, Franklin; Bubley, Glenn; Goddard, J; Dunbar, Joi; Ross, Robert W

2011-01-01

Objectives Evaluation of clinical activity and safety of IPI-504 (retaspimycin hydrochloride) in patients with castration-resistant prostate cancer (CRPC). Methods A single arm trial was conducted in two cohorts: Group A (chemotherapy-naïve), Group B (docetaxel-treated). IPI-504 was administered intravenously at 400 mg/m2 on Days 1, 4, 8, and 11 of a 21-day cycle. Trial expansion was planned if at least one prostate specific antigen (PSA) or radiographic response was noted per cohort. Pharmacokinetic samples were collected following the first dose; safety was assessed throughout. Results Nineteen patients were enrolled (4 in Group A; 15 in Group B), with a median age of 66 years (range 49-78). Group B had received a median of 2 prior chemotherapy regimens. All Group B patients had bone metastases; 66% had measurable soft tissue or visceral metastases. One Group A patient remained on trial for 9 cycles; PSA declined 48% from baseline. No PSA responses were observed in other patients. Adverse events reported in >25% of the study population included nausea (47%), diarrhea (42%), fatigue (32%), anorexia (26%), and arthralgia (26%). Two patients in Group B died on study, involving study drug-related events of hepatic failure and ketoacidosis, respectively. Conclusions In this study, Hsp90 inhibition with IPI-504 administered as a single agent had a minimal effect on PSA or tumor burden and was associated with unacceptable toxicity in several patients; therefore, further evaluation in CRPC patients is not warranted. IPI-504 is being investigated at less intensive doses and schedules in other tumor types. PMID:21762967

Neglected Intestinal Parasites, Malnutrition and Associated Key Factors: A Population Based Cross-Sectional Study among Indigenous Communities in Sarawak, Malaysia

PubMed Central

Rajoo, Yamuna; Ambu, Stephen; Lim, Yvonne Ai Lian; Rajoo, Komalaveni; Tey, Siew Chang; Lu, Chan Woon; Ngui, Romano

2017-01-01

Intestinal parasitic infections (IPIs) have been recognized as one of the most significant causes of illness among disadvantaged communities. Many studies have been conducted on the prevalence of IPIs in Malaysia. However, these studies mostly focused on the indigenous groups in Peninsular Malaysia. The present study was conducted to provide the current baseline data on prevalence of IPIs, anaemia, malnutrition and associated risk factors among the indigenous communities in Sarawak, situation at northwest Borneo island of Malaysia. A cross sectional study was conducted among the longhouses communities. Stool samples were obtained and examined for the presence of IPIs using microscopy technique. Haemoglobin measurement was done using a portable haemoglobin analyzer. Malnutrition (i.e., stunting, underweight and wasting) was assessed using the WHO Anthro software. Statistical analysis was carried out using SPSS software. A total of 341participants took part in this study. The overall prevalence of IPIs was 57.5%. Multivariate analysis indicated that the absence of toilets (OR = 1.6; 95% CI = 1.1–2.7; p = 0.002) and close contact with animals (OR = 1.8; 95% CI = 1.3–2.9; p = 0.027) as significant predictors for IPIs. The incidence of anaemia was 36.4%. The incidence of underweight, wasting and stunting were 22.2%, 5.6% and 35.4%, respectively. Multivariate analysis demonstrated that low level of parental education attainment (OR = 1.9; 95% CI = 1.2–3.0; p = 0.006) was identified as significant predictor for anaemia. The incidence of wasting was significantly associated with mild anaemia (OR = 1.2; 95% CI = 0.9–1.7; p = 0.024). Low household income was identified as significant predictor for stunting (OR = 2.1; 95% CI = 9.8–22.2; p = 0.001) and underweight (OR = 1.9; 95% CI = 5.6–18.7; p = 0.037), respectively. Essentially, the present study highlighted that intestinal parasitic infections, anaemia and malnutrition are still prevalent among rural indigenous community in Sarawak. Improvement of socioeconomic status, periodic mass deworming, iron supplementation and health education program should be included in the control and prevention of public health strategies. PMID:28095446

[Treatment outcome and prognosis of autologous hematopoietic stem cell transplantation combined with high dose radiotherapy/chemotherapy in 22 patients with nasal NK/T cell lymphoma].

PubMed

Cui, Xiu-Zhen; Wang, Hua-Qing; Liu, Xian-Ming; Zhang, Hui-Lai; Li, Wei

2007-09-01

To analyze the outcome and prognosis of autologous hematopoietic stem cell transplantation (AHSCT) combined with high dose radiotherapy/chemotherapy in 22 patients with nasal NK/T cell lymphoma. From July 1992 to December 2005, 22 patients with nasal NK/T cell lymphoma were diagnosed pathologically. Immunophenotyping was performed in 13 cases. The patients were classified by Ann Arbor staging system and international prognosis index (IPI). The patients received cycles of chemotherapy every other two weeks or combined with radiotherapy for remission induction, followed high dose radiotherapy/chemotherapy, combined with autologous peripheral blood stem cell transplantation (APBSCT), or autologous bone-marrow transplantation (ABMT). Patients were given complementary radiotherapy after transplantation if they did not have it before. Twelve patients of IPI 3 -4 received consolidation chemotherapy, and one of them received the second transplantation. The median follow-up duration was 64 (12 - 168) months. The 5 and 8-year overall survivals (OS) were 79.3% and 64.1%, and disease free survivals (DFS) were 36.4% and 27.3%, respectively. The 5-year OS were as follows: for stage I - II and III - IV disease were 90.0% and 70.0% (P = 0. 041); for patients without and with B symptom were 100.0% and 70.7% (P = 0.045); and for IPI 1 - 2 and 3 - 4 were 100.0% and 60.0% (P = 0.035), respectively. Multivariate analysis by COX regression revealed that disease stage, B symptom and IPI were independent prognostic factors. AHSCT combined with high dose radiotherapy/chemotherapy is an effective treatment for patients with poor prognosis nasal NK/T cell lymphoma.

Information And Data-Sharing Plan of IPY China Activity

NASA Astrophysics Data System (ADS)

Zhang, X.; Cheng, W.

2007-12-01

Polar Data-Sharing is an effective resolution to global system and polar science problems and to interdisciplinary and sustainable study, as well as an important means to deal with IPY scientific heritages and realize IPY goals. Corresponding to IPY Data-Sharing policies, Information and Data-Sharing Plan was listed in five sub-plans of IPY Chinese Programme launched in March, 2007,they are Scientific research program of the Prydz Bay, Amery Ice Shelf and Dome A transects(short title:'PANDA'), the Arctic Scientific Research Expedition Plan, International Cooperation Plan, Information and Data-Sharing Plan, Education and Outreach. China, since the foundation of Antarctic Zhongshan Station in 1989, has carried out systematic scientific expeditions and researches in Larsemann Hills, Prydz Bay and the neighbouring sea areas, organized 14 Prydz Bay oceanographic investigations, 3 Amery Ice Shelf expeditions, 4 Grove Mountains expeditions and 5 inland ice cap scientific expeditions. 2 comprehensive oceanographic investigations in the Arctic Ocean were conducted in 1999 and 2003, acquired a large amount of data and samples in PANDA section and fan areas of Pacific Ocean in the Arctic Ocean. A mechanism of basic data submitting ,sharing and archiving has been gradually set up since 2000. Presently, Polar Science Database and Polar Sample Resource Sharing Platform of China with the aim of sharing polar data and samples has been initially established and began to provide sharing service to domestic and oversea users. According to IPY Chinese Activity, 2 scientific expeditions in the Arctic Ocean, 3 in the South Ocean, 2 at Amery Ice Shelf, 1 on Grove Mountains and 2 inland ice cap expeditions on Dome A will be carried out during IPY period. According to the experiences accumulated in the past and the jobs in the future, the Information and Data- Sharing Plan, during 2007-2010, will save, archive, and provide exchange and sharing services upon the data obtained by scientific expeditions on the site of IPY Chinese Programme. Meanwhile, focusing on areas in east Antarctic Dome A-Grove Mountain-Zhongshan Station-Amery Ice Shelf-Prydz Bay Section and the fan areas of Pacific Ocean in the Arctic Ocean, the Plan will also collect and integrate IPY data and historical data and establish database of PANDA Section and the Arctic Ocean. The details are as follows: On the basis of integrating the observed data acquired during the expeditions of China, the Plan will, adopting portal technology, develop 5 subject databases (English version included):(1) Database of Zhongshan Station- Dome A inner land ice cap section;(2) Database of interaction of ocean-ice-atmosphere-ice shelf in east Antarctica;(3) Database of geological and glaciological advance and retreat evolvement in Grove Mountains; (4) Database of Solar Terrestrial Physics at Zhongshan Station; (5) Oceanographic database of fan area of Pacific Ocean in the Arctic Ocean. CN-NADC of PRIC is the institute which assumes the responsibility for the Plan, specifically, it coordinates and organizes the operation of the Plan which includes data management, developing the portal of data and information sharing, and international exchanges. The specific assignments under the Plan will be carried out by research institutes under CAS (Chinese Academy of Sciences), SOA ( State Oceanic Administration), State Bureau of Surveying and Mapping and Ministry of Education.

Integrated Practice Improvement Solutions-Practical Steps to Operating Room Management.

PubMed

Chernov, Mikhail; Pullockaran, Janet; Vick, Angela; Leyvi, Galina; Delphin, Ellise

2016-10-01

Perioperative productivity is a vital concern for surgeons, anesthesiologists, and administrators as the OR is a major source of hospital elective admissions and revenue. Based on elements of existing Practice Improvement Methodologies (PIMs), "Integrated Practice Improvement Solutions" (IPIS) is a practical and simple solution incorporating aspects of multiple management approaches into a single open source framework to increase OR efficiency and productivity by better utilization of existing resources. OR efficiency was measured both before and after IPIS implementation using the total number of cases versus room utilization, OR/anesthesia revenue and staff overtime (OT) costs. Other parameters of efficiency, such as the first case on-time start and the turnover time (TOT) were measured in parallel. IPIS implementation resulted in increased numbers of surgical procedures performed by an average of 10.7%, and OR and anesthesia revenue increases of 18.5% and 6.9%, respectively, with a simultaneous decrease in TOT (15%) and OT for anesthesia staff (26%). The number of perioperative adverse events was stable during the two-year study period which involved a total of 20,378 patients. IPIS, an effective and flexible practice improvement model, was designed to quickly, significantly, and sustainably improve OR efficiency by better utilization of existing resources. Success of its implementation directly correlates with the involvement of and acceptance by the entire OR team and hospital administration.

Promoting contraceptive use among female rural-to-urban migrants in Qingdao, China: a comparative impact study of worksite-based interventions.

PubMed

Decat, Peter; Zhang, Wei-Hong; Delva, Wim; Moyer, Eileen; Cheng, Yimin; Wang, Zhi-Jin; Lu, Ci-Yong; Wu, Shi-Zhong; Nadisauskiene, Ruta Jolanta; Temmerman, Marleen; Degomme, Olivier

2012-10-01

We conducted a comparative study in worksites to assess the impact of sexual health promoting interventions on contraceptive use among female rural-to-urban migrants. In Qingdao ten manufacturing worksites were randomly allocated to a standard package of interventions (SPI) and an intensive package of interventions (IPI). The interventions ran from July 2008 to January 2009. Cross-sectional surveys at baseline and end line assessed the sexual behaviour of young female migrants. To evaluate the impact of the interventions we assessed pre- and post-time trends. From the SPI group 721 (baseline) and 615 (end line) respondents were considered. Out of the IPI group we included 684 and 603 migrants. Among childless migrants, self-reported contraceptive use increased significantly after SPI and IPI (adjusted odds ratio [aOR] = 3.23; 95% confidence interval [CI] = 1.52-6.84; p < 0.01 and aOR = 5.81; 95% CI = 2.63-12.80; p < 0.001, respectively). Childless migrants older than 22 years reported a greater use after IPI than after SPI. Implementing current Chinese sexual health promotion programmes at worksites is likely to have a positive impact on migrant women working in the manufacturing industry of Qingdao. More comprehensive interventions seem to have an added value if they are well targeted to specific groups.

Antarctic Super Heroes: Using a Graphic Novel to Teach Students About Polar Science. (Invited)

NASA Astrophysics Data System (ADS)

Lougheed, V.; Palsole, S.; Rojas, C.; Tweedie, C. E.

2009-12-01

The University of Texas at El Paso received an IPY grant from the US National Science Foundation to take undergraduate and graduate students, as well as teachers, to Antarctica over winter break 2007. The program, called IPY-ROAM (International Polar Year - Research and Educational Experiences in Antarctica for Minorities) aimed to increase the number of underrepresented minorities in the sciences, and increase public awareness about the polar regions. Education and outreach activities have been designed to teach people of all ages about polar science. For example, an interactive museum exhibit was designed to describe how the polar regions are being affected by climate change, and how individuals can make a difference. Our latest outreach strategy involves taking the large amount of educational materials collected for the museum display and making it available to a broader audience. We have created a graphic novel where the story of the ROAM Antarctic trip and existing educational materials are communicated using a combination of comic strips, fact sheets, and classroom activities. Photographic images from the ROAM trip were digitized and converted to a comic strip format. These images were combined with text from film footage collected by a documentary film, as well as personal anecdotes, to convey the successes of the program and the primary messages participants wanted to share with the public. The graphic novel will be made available to local school groups and online, at our website: www.ipyroam.org.

Enhancing the Environmental Legacy of the International Polar Year 2007- 2008

NASA Astrophysics Data System (ADS)

Tin, T.; Roura, R.; Perrault, M.

2006-12-01

The International Geophysical Year (IGY) left a legacy of peace and international cooperation in the form of the 1959 Antarctic Treaty. Since the IGY, the 1991 Protocol of Environmental Protection to the Antarctic Treaty was signed and entered into force. The Protocol establishes that the protection of the environment and the wilderness values of Antarctica "shall be fundamental considerations in the planning and conduct of all activities in the Antarctic Treaty area". Fifty years on, the IPY 2007-08 can, in turn, leave behind a positive environmental legacy - where the sharing of facilities and logistics are encouraged, the human footprint in Antarctica is minimized and a future generation of environmentally aware scientists, logisticians and visitors is fostered. Based on an analysis of all Expressions of Interest submitted to the IPY, we found that about three-quarters of IPY's Antarctic projects plan to have fieldwork components. About one-third of these field projects expect to leave physical infrastructure in Antarctica. A number of projects plan to develop large-scale infrastructure, such as stations and observatories, in hitherto pristine areas. Fewer than one percent of Antarctic field projects address the issue of their environmental legacy: four projects indicated that the site will be cleaned up or the equipment will be removed at the end of the project; two projects indicated that their results may be useful for the management of the Antarctic environment, e.g., in the control of invasive species or setting up of marine protected areas. With the goal of increasing the environmental awareness of Antarctic field scientists, our contribution will review current research on the impacts of human activities science, tourism, exploitation of marine resources and global climate change - on the Antarctic environment. A preliminary analysis of the cumulative impacts of IPY activities will be presented. Case studies of scientific projects in Antarctica with a potentially positive environmental legacy will be highlighted, and suggestions of actions that could be taken to increase the environmental friendliness of scientific projects will be discussed.

Combined Effect of Random Transmit Power Control and Inter-Path Interference Cancellation on DS-CDMA Packet Mobile Communications

NASA Astrophysics Data System (ADS)

Kudoh, Eisuke; Ito, Haruki; Wang, Zhisen; Adachi, Fumiyuki

In mobile communication systems, high speed packet data services are demanded. In the high speed data transmission, throughput degrades severely due to severe inter-path interference (IPI). Recently, we proposed a random transmit power control (TPC) to increase the uplink throughput of DS-CDMA packet mobile communications. In this paper, we apply IPI cancellation in addition to the random TPC. We derive the numerical expression of the received signal-to-interference plus noise power ratio (SINR) and introduce IPI cancellation factor. We also derive the numerical expression of system throughput when IPI is cancelled ideally to compare with the Monte Carlo numerically evaluated system throughput. Then we evaluate, by Monte-Carlo numerical computation method, the combined effect of random TPC and IPI cancellation on the uplink throughput of DS-CDMA packet mobile communications.

Comparative analytics of infusion pump data across multiple hospital systems.

PubMed

Catlin, Ann Christine; Malloy, William X; Arthur, Karen J; Gaston, Cindy; Young, James; Fernando, Sudheera; Fernando, Ruchith

2015-02-15

A Web-based analytics system for conducting inhouse evaluations and cross-facility comparisons of alert data generated by smart infusion pumps is described. The Infusion Pump Informatics (IPI) project, a collaborative effort led by research scientists at Purdue University, was launched in 2009 to provide advanced analytics and tools for workflow analyses to assist hospitals in determining the significance of smart-pump alerts and reducing nuisance alerts. The IPI system allows facility-specific analyses of alert patterns and trends, as well as cross-facility comparisons of alert data uploaded by more than 55 participating institutions using different types of smart pumps. Tools accessible through the IPI portal include (1) charts displaying aggregated or breakout data on the top drugs associated with alerts, numbers of alerts per device or care area, and override-to-alert ratios, (2) investigative reports that can be used to characterize and analyze pump-programming errors in a variety of ways (e.g., by drug, by infusion type, by time of day), and (3) "drill-down" workflow analytics enabling users to evaluate alert patterns—both internally and in relation to patterns at other hospitals—in a quick and efficient stepwise fashion. The formation of the IPI analytics system to support a community of hospitals has been successful in providing sophisticated tools for member facilities to review, investigate, and efficiently analyze smart-pump alert data, not only within a member facility but also across other member facilities, to further enhance smart pump drug library design. Copyright © 2015 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

Prevalence and co-infection of intestinal parasites among thai rural residents at high-risk of developing cholangiocarcinoma: a cross-sectional study in a prospective cohort study.

PubMed

Songserm, Nopparat; Promthet, Supannee; Wiangnon, Surapon; Sithithaworn, Paiboon

2012-01-01

Intestinal parasitic infections (IPIs) are still important to the health of Thai rural residents. IPIs are the cause of many chronic diseases with, for example, opisthorchiasis resulting in progression to cholangiocarcinoma (CCA). This cross-sectional study in a prospective cohort study aimed to examine the prevalence and co- infection of intestinal parasites among Northeastern Thai rural residents, recruited into the Khon Kaen Cohort Study (KKCS), and who were residing in areas of high-risk for developing CCA. On recruitment, subjects had completed questionnaires and provided fecal samples for IPI testing using the formalin ethyl acetate concentration technique. Data on selected general characteristics and the results of the fecal tests were analysed. IPI test results were available for 18,900 of cohort subjects, and 38.50% were found to be positive for one or more types of intestinal parasite. The prevalence of Opisthorchis viverrini (O. viverrini) infection was the highest (45.7%), followed by intestinal flukes (31.9%), intestinal nematodes (17.7%), intestinal protozoa (3.02%), and intestinal cestodes (1.69%). The pattern of different infections was similar in all age groups. According to a mapping analysis, a higher CCA burden was correlated with a higher prevalence of O. viverrini and intestinal flukes and a greater intensity of O. viverrini. Both prevention and control programs against liver fluke and other intestinal parasites are needed and should be delivered simultaneously. We can anticipate that the design of future control and prevention programmes will accommodate a more community-orientated and participatory approach.

Outcomes of cup revision for ilio-psoas impingement after total hip arthroplasty: Retrospective study of 46 patients.

PubMed

Batailler, C; Bonin, N; M Wettstein; Nogier, A; Martres, S; Ollier, E; May, O; Lustig, S

2017-12-01

Impingement of the ilio-psoas tendon on the acetabular component is a cause of pain after total hip arthroplasty (THA). Studies of cup revision for ilio-psoas impingement (IPI) are scarce and limited in size. We therefore conducted a large multicentre retrospective study with the following objectives: to assess the effectiveness of cup replacement in resolving the impingement syndrome, to determine the frequency and nature of complications after cup revision for IPI, and to identify pre-operative factors associated with good outcomes of cup revision for IPI. Cup revision is effective in resolving the pain due to IPI in selected patients. This retrospective multicentre study included 46 patients who underwent cup revision because of IPI. Before the revision, 38 (83%) patients had prominence of the anterior cup rim (mean, 9.9±4.5mm (range, 2-22mm) by radiography and 35 (76%) had cup malposition (anteversion<10° and/or inclination>50°). Mean follow-up was 21months (range, 6months to 6 years) and no patient was lost to follow-up. Outcomes at last follow-up were assessed based on the Oxford Hip Score (OHS), patient satisfaction index, complications, and revisions. At last follow-up, 39 (85%) patients were satisfied with the revision procedure, a significant improvement versus baseline was noted in the OHS (mean, 43±6; range, 25-48; P<0.001), and 41 patients were free of pain during hip flexion (P<0.001 versus baseline). Complications occurred in 3 (6.5%) patients, but only one complication was severe (deep infection). Recurrent groin pain was reported by 4 (8.7%) patients at last follow-up. None of the factors studied predicted the outcome of revision surgery. Cup revision for IPI after THA is effective in relieving the groin pain in 80% of patients with anterior cup rim prominence and/or cup malposition. However, complications can occur. Tenotomy may be preferable when the diagnosis is in doubt and/or cup position is acceptable. IV, retrospective observational study. Published by Elsevier Masson SAS.

Intestinal parasitic infections: Current prevalence and risk factors among schoolchildren in capital area of the Republic of Marshall Islands.

PubMed

Liao, Chien-Wei; Chuang, Ting-Wu; Huang, Ying-Chieh; Chou, Chia-Mei; Chiang, Chia-Lien; Lee, Fei-Peng; Hsu, Yun-Ting; Lin, Jia-Wei; Briand, Kennar; Tu, Chia-Ying; Fan, Chia-Kwung

2017-12-01

Intestinal parasitic infections (IPIs) among schoolchildren in Republic of Marshall Islands (RMI) largely remains unknown, thus investigation on IPIs status to establish the baseline data is urgently needed. This cross-sectional study intended to investigate the current IPIs status and associated risk factors among schoolchildren at capital of RMI. Single stool sample from 400 schoolchildren (207 boys and 193 girls) aged 9.73±2.50 yrs old was examined by employing merthiolate-iodine-formaldehyde concentration method. Demographic characteristics, uncomfortable symptoms and risk factors were obtained by questionnaires investigation. The overall prevalence of IPIs in schoolchildren was 22.8% (91/400), of them 24.2% harbored at least 2 different parasites. Notably, the majority was infected by waterborne protozoan parasites (82.4%, 75/91). Nine different intestinal parasites have been identified, of which six were pathogenic including Hook worm, Trichuris trichiura, Enterobius vermicularis, Entamoeba histolytica/dispar, Giardia intestinalis and Blastocystis hominis. Schoolchildren who ever complained dizziness or headache showed a significant higher prevalence of pathogenic IPIs than those who did not (p<0.05). Schoolchildren who lived in urban area than rural area had higher chance to acquire pathogenic IPIs (p=0.03). However, none of risk factors were identified to be associated with pathogenic IPIs. Copyright © 2017 Elsevier B.V. All rights reserved.

Phenotypic Detection of Metallo-β-Lactamase in Imipenem-Resistant Pseudomonas aeruginosa

PubMed Central

Khosravi, Yalda; Loke, Mun Fai; Chua, Eng Guan; Tay, Sun Tee; Vadivelu, Jamuna

2012-01-01

Carbapenems are the primary choice of treatment for severe Pseudomonas aeruginosa infection. However, the emergence of carbapenem resistance due to the production of metallo-β-lactamases (MBLs) is of global concern. In this study, 90 imipenem- (IPM- or IP-) resistant P. aeruginosa (IRPA) isolates, including 32 previously tested positive and genotyped for MBL genes by PCR, were subjected to double-disk synergy test (DDST), combined disk test (CDT), and imipenem/imipenem-inhibitor (IP/IPI) E-test to evaluate their MBLs detection capability. All three methods were shown to have a sensitivity of 100%. However, DDST was the most specific of the three (96.6%), followed by IP/IPI E-test interpreted based on the single criteria of IP/IPI ≥8 as positive (62.1%), and CDT was the least specific (43.1%). Based on the data from this evaluation, we propose that only IRPA with IP MIC >16 μg/mL and IP/IPI ≥8 by IP/IPI E-test should be taken as positive for MBL activity. With the new dual interpretation criteria, the MBL IP/IPI E-test was shown to achieve 100% sensitivity as well as specificity for the IRPA in this study. Therefore, the IP/IPI E-test is a viable alternative phenotypic assay to detect MBL production in IRPA in our population in circumstances where PCR detection is not a feasible option. PMID:22792048

Teacher Perceptions of School Consultant Social Influence Strategies: Replication and Expansion

ERIC Educational Resources Information Center

Owens, Julie Sarno; Schwartz, Madeleine E.; Erchul, William P.; Himawan, Lina K.; Evans, Steven W.; Coles, Erika K.; Schulte, Ann C.

2017-01-01

The goals were to (a) replicate the findings of previous research with regard to the Consultee/Teacher Version of the Interpersonal Power Inventory (IPI), and (b) advance the literature by examining IPI scores about a current consultation relationship. Sample 1 included 99 elementary school teachers (44.4% Hispanic) who completed the IPI. Results…

Microscopic analysis of irradiated AGR-1 coated particle fuel compacts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scott A. Ploger; Paul A. Demkowicz; John D. Hunn

The AGR-1 experiment involved irradiation of 72 TRISO-coated particle fuel compacts to a peak compact-average burnup of 19.5% FIMA with no in-pile failures observed out of 3 x 105 total particles. Irradiated AGR-1 fuel compacts have been cross-sectioned and analyzed with optical microscopy to characterize kernel, buffer, and coating behavior. Six compacts have been examined, spanning a range of irradiation conditions (burnup, fast fluence, and irradiation temperature) and including all four TRISO coating variations irradiated in the AGR-1 experiment. The cylindrical specimens were sectioned both transversely and longitudinally, then polished to expose from 36 to 79 individual particles near midplanemore » on each mount. The analysis focused primarily on kernel swelling and porosity, buffer densification and fracturing, buffer–IPyC debonding, and fractures in the IPyC and SiC layers. Characteristic morphologies have been identified, 981 particles have been classified, and spatial distributions of particle types have been mapped. No significant spatial patterns were discovered in these cross sections. However, some trends were found between morphological types and certain behavioral aspects. Buffer fractures were found in 23% of the particles, and these fractures often resulted in unconstrained kernel protrusion into the open cavities. Fractured buffers and buffers that stayed bonded to IPyC layers appear related to larger pore size in kernels. Buffer–IPyC interface integrity evidently factored into initiation of rare IPyC fractures. Fractures through part of the SiC layer were found in only four classified particles, all in conjunction with IPyC–SiC debonding. Compiled results suggest that the deliberate coating fabrication variations influenced the frequencies of IPyC fractures and IPyC–SiC debonds.« less

Clinical efficiency of Piezo-ICSI using micropipettes with a wall thickness of 0.625 μm.

PubMed

Hiraoka, Kenichiro; Kitamura, Seiji

2015-12-01

The purposes of the present study are to assess the clinical efficiency of Piezo-intracytoplasmic sperm injection (ICSI) and to improve the Piezo-ICSI method for human oocytes. We examined three ICSI methods to determine their clinical efficiency by comparing the survival, fertilization, good-quality day-3 embryo, pregnancy, and live birth rates. The three ICSI methods tested were conventional ICSI (CI) (using beveled spiked micropipettes with a wall thickness of 1 μm), conventional Piezo-ICSI (CPI) (using flat-tipped micropipettes with a wall thickness of 0.925 μm), and improved Piezo-ICSI (IPI) (using flat-tipped micropipettes with a wall thickness of 0.625 μm). We collectively investigated 2020 mature oocytes retrieved from 437 patients between October 2010 and January 2014. The survival rates after CI, CPI, and IPI were 90, 95, and 99 %, respectively. The fertilization rates after CI, CPI, and IPI were 68, 75, and 89 %, respectively. The good-quality day-3 embryo rates after CI, CPI, and IPI were 37, 43, and 55 %, respectively. The pregnancy rates after the transfer of good-quality day-3 embryo of CI, CPI, and IPI were 19, 21, and 31 %, respectively. The live birth rates of CI, CPI, and IPI were 15, 16, and 25 %, respectively. Significantly higher survival, fertilization, good-quality day-3 embryo, pregnancy, and live birth rates were obtained using IPI. When comparing the IPI to the CI and CPI, the results revealed that the Piezo-ICSI using flat-tipped micropipettes with a wall thickness of 0.625 μm significantly improves survival, fertilization, good-quality day-3 embryo, pregnancy, and live birth rates.

Intestinal parasitic infections among prison inmates and tobacco farm workers in Shewa Robit, north-central Ethiopia.

PubMed

Mamo, Hassen

2014-01-01

Intestinal parasitic infections (IPIs) particularly soil-transmitted helminthiasis (STH) and schistosomiasis are among neglected tropical diseases (NTDs) globally. Apart from being associated with anemia, malabsorption and retarded cognitive development these diseases are complicating the clinical picture of more serious infections like HIV, TB and malaria. Renewed and up-to-date information on the epidemiology of IPIs in more vulnerable groups such as irrigated-farm workers and prisoners would significantly contribute towards improving the health condition of such at-risk groups. A cross-sectional survey was conducted to determine the prevalence of IPIs among prison inmates and tobacco farm workers in Shewa-Robit, north-central Ethiopia in November 2008. A total of 236 fecal samples were examined microscopically to detect helminths and/or protozoa using direct-smear and formol-ether concentration methods. Overall, 8 intestinal parasite species have been recovered singly or in combinations from 146 (61.8 %) samples. The prevalence in prison population (88/121 = 72.7%) was significantly higher than that in tobacco farm (58/115 = 50.4%). There were no significant differences in the prevalence of IPI by most socio-demographics. Except for hookworm there was no significant difference in parasite prevalence between different age-groups though the frequency of individual parasites slightly varied between the age-groups. Multivariate logistic regression analysis showed that inmates were more likely to acquire IPIs than tobacco-farm workers (Odds Ratio (OR) = 2.62, 95% confidence interval (CI) = 1.52-4.5). In addition, participants who did not report past treatment for IPIs were more likely to acquire IPIs than participants who self-reported treatment for IPIs in the past twelve months (OR = 3.25, 95% CI = 1.75-6.06). All other socio-demographics were not significantly associated with IPIs in univariate analysis. Entamoeba histolytica/dispar/moshkovskii was the most frequently encountered species in both study sites accounting for 48.8 and 51.7 percent of the positives in prison and tobacco farm population respectively. Other intestinal parasites detected, with slight variation in prevalence in the two study areas, were hookworm, Ascaris lumbricoides, Trichuris trichiura, Schistosoma mansoni, Strongyloides stercolaris, Hymenolepis nana and Taenia sp. 35.5 and 33.0 percent of the total positive cases were mixed infections in Shewa Robit prison and tobacco farm, respectively. The results show that IPIs are common health problems in the studied populations.

i-PI: A Python interface for ab initio path integral molecular dynamics simulations

NASA Astrophysics Data System (ADS)

Ceriotti, Michele; More, Joshua; Manolopoulos, David E.

2014-03-01

Recent developments in path integral methodology have significantly reduced the computational expense of including quantum mechanical effects in the nuclear motion in ab initio molecular dynamics simulations. However, the implementation of these developments requires a considerable programming effort, which has hindered their adoption. Here we describe i-PI, an interface written in Python that has been designed to minimise the effort required to bring state-of-the-art path integral techniques to an electronic structure program. While it is best suited to first principles calculations and path integral molecular dynamics, i-PI can also be used to perform classical molecular dynamics simulations, and can just as easily be interfaced with an empirical forcefield code. To give just one example of the many potential applications of the interface, we use it in conjunction with the CP2K electronic structure package to showcase the importance of nuclear quantum effects in high-pressure water. Catalogue identifier: AERN_v1_0 Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AERN_v1_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licensing provisions: GNU General Public License, version 3 No. of lines in distributed program, including test data, etc.: 138626 No. of bytes in distributed program, including test data, etc.: 3128618 Distribution format: tar.gz Programming language: Python. Computer: Multiple architectures. Operating system: Linux, Mac OSX, Windows. RAM: Less than 256 Mb Classification: 7.7. External routines: NumPy Nature of problem: Bringing the latest developments in the modelling of nuclear quantum effects with path integral molecular dynamics to ab initio electronic structure programs with minimal implementational effort. Solution method: State-of-the-art path integral molecular dynamics techniques are implemented in a Python interface. Any electronic structure code can be patched to receive the atomic coordinates from the Python interface, and to return the forces and energy that are used to integrate the equations of motion. Restrictions: This code only deals with distinguishable particles. It does not include fermonic or bosonic exchanges between equivalent nuclei, which can become important at very low temperatures. Running time: Depends dramatically on the nature of the simulation being performed. A few minutes for short tests with empirical force fields, up to several weeks for production calculations with ab initio forces. The examples provided with the code run in less than an hour.

Students and Teachers Conduct an Assessment of Antarctic Peninsula Ecosystems and Take Their Research into Classrooms.

NASA Astrophysics Data System (ADS)

Lougheed, V. L.; Tweedie, C. E.; Robertson, W. H.; Velasco, A. A.; Garcia, C. V.

2008-12-01

The University of Texas at El Paso received an IPY grant from the US National Science Foundation to take undergraduate and graduate students, as well as teachers, to Antarctica over winter break 2007. The program, called IPY-ROAM (International Polar Year - Research and Educational Experiences in Antarctica for Minorities) aimed to increase the number of underrepresented minorities in the sciences, and increase public awareness about the polar regions. Participants completed research projects in terrestrial ecology, marine sciences, geosciences and tourism policy, and helped design education products to take this science into classrooms. All data were collected during a 10-day expedition aboard a tourist vessel in December 2007, which included 8 landings in the Antarctic Peninsula region. Student projects found that, in nearshore areas adjacent to penguin colonies, water column nutrients were elevated and algal communities were relatively unique, whereas algal communities found at sites without penguins tended to be more similar to each other. Similarly, student working on land found that penguin rookery size has a distinct impact on plant community composition, biomass and CO2 efflux. Education and outreach activities directed at schools across the US will take data and techniques from this research to teach students about polar science.

From Auroras to Sea Ice: Views From the International Space Station and Plans for International Polar Year

NASA Astrophysics Data System (ADS)

Evans, C. A.; Runco, S. K.; Willis, K.; Heydorn, J.; Trenchard, M.; Stefanov, W. L.; Wilkinson, M. J.

2006-12-01

For more than 40 years astronauts have been observing Earth, taking photographs or digital images from their spacecraft. Today, a robust program of observation from the International Space Station (ISS) has yielded hundreds of thousands of images of the Earth's surface collected since 2001. Seeing Earth through the eyes of an astronaut is exciting to the general public, and the images are popular in classrooms. Because the ISS has an orbital inclination of 51.6 degrees (the north-south limits of the orbit are at 51.6 degrees latitude), high latitude observations are common. Some of the most striking images collected include views of polar phenomena. Astronauts routinely pass above brilliant red and green aurora; view high, wispy clouds at the top of the atmosphere; or look down on glaciers and floating ice rafts. These images, framed and captured by humans, are easily interpreted by students and teachers. Astronaut observations provide a way to visualize complicated polar phenomena and communicate about them to students of all ages. Over the next two years, astronauts aboard the ISS will formally focus their observations on polar phenomena as participants in the International Polar Year (IPY). Imagery acquisition from the ISS will be coordinated with other IPY scientists staging studies and field campaigns on the ground. The imagery collected from the ISS will be cataloged and served on NASA's web-based database of images, http://eol.jsc.nasa.gov . The website allows investigators, students and teachers to search through the imagery, assemble image datasets, and download the imagery and the metadata. We display some of the most spectacular examples of polar imagery and demonstrate NASA's database of astronaut images of Earth.

Decadal Time Scale change in terrestrial plant communities in North American arctic and alpine tundra: A contribution to the International Polar Year Back to the Future Project (Invited)

NASA Astrophysics Data System (ADS)

Tweedie, C. E.; Ebert-May, D.; Hollister, R. D.; Johnson, D. R.; Lara, M. J.; Villarreal, S.; Spasojevic, M.; Webber, P.

2010-12-01

The International Polar Year-Back to the Future (IPY-BTF) is an endorsed International Polar Year project (IPY project #214). The overarching goal of this program is to determine how key structural and functional characteristics of high latitude/altitude terrestrial ecosystems have changed over the past 25 or more years and assess if such trajectories of change are likely to continue in the future. By rescuing data, revisiting, re-sampling historic research sites and assessing environmental change over time, we aim to provide greater understanding of how tundra is changing and what the possible drivers of these changes are. Resampling of sites established by Patrick J. Webber between 1964 and 1975 in northern Baffin Island, Northern Alaska and in the Rocky Mountains form a key contribution to the BTF project. Here we report on resampling efforts at each of these locations and initial results of a synthesis effort that finds similarities and differences in change between sites. Results suggest that although shifts in plant community composition are detectable at each location, the magnitude and direction of change differ among locations. Vegetation shifts along soil moisture gradients is apparent at most of the sites resampled. Interestingly, however, wet communities seem to have changed more than dry communities in the Arctic locations, while plant communities at the alpine site appear to be becoming more distinct regardless of soil moisture status. Ecosystem function studies performed in conjunction with plant community change suggest that there has been an increase in plant productivity at most sites resampled, especially in wet and mesic land cover types.

From Auroras to Sea Ice: Views From the International Space Station and Plans for International Polar Year

NASA Technical Reports Server (NTRS)

Evans, Cynthia A.; Runco, Susan K.; Heydorn, James; Trenchard, Michael; Stefanov, William L.; Wilkinson, M. Justin

2006-01-01

For more than 40 years astronauts have been observing Earth, taking photographs or digital images from their spacecraft. Today, a robust program of observation from the International Space Station (ISS) has yielded hundreds of thousands of images of the Earth s surface collected since 2001. Seeing Earth through the eyes of an astronaut is exciting to the general public, and the images are popular in classrooms. Because the ISS has an orbital inclination of 51.6 degrees (the north-south limits of the orbit are at 51.6 degrees latitude), high latitude observations are common. Some of the most striking images collected include views of polar phenomena. Astronauts routinely pass above brilliant red and green aurora; view high, wispy clouds at the top of the atmosphere; or look down on glaciers and floating ice rafts. These images, framed and captured by humans, are easily interpreted by students and teachers. Astronaut observations provide a way to visualize complicated polar phenomena and communicate about them to students of all ages. Over the next two years, astronauts aboard the ISS will formally focus their observations on polar phenomena as participants in the International Polar Year (IPY). Imagery acquisition from the ISS will be coordinated with other IPY scientists staging studies and field campaigns on the ground. The imagery collected from the ISS will be cataloged and served on NASA s web-based database of images, http://eol.jsc.nasa.gov . The website allows investigators, students and teachers to search through the imagery, assemble image datasets, and download the imagery and the metadata. We display some of the most spectacular examples of polar imagery and demonstrate NASA s database of astronaut images of Earth.

Correlates of Achievement in an IPI School.

ERIC Educational Resources Information Center

Rookey, T. Jerome

An attempt was made to determine what factors relate to achievement in language arts, mathematics, and certain attitudes in an individualized programmed instruction school. A total of 87 fifth grade pupils were tested both in the Fall and Spring using the Commonwealth of Pennsylvania's Pennsylvania Questionnaire and the Stanford Achievement Test.…

Prevalence, risk factors and clinical features associated with intestinal parasitic infections in children from San Juan y Martínez, Pinar del Río, Cuba.

PubMed

Escobedo, A A; Cañete, R; Núñez, F A

2008-09-01

A cross-sectional study was carried out in 200 children aged 5-15 years, to examine the presence of intestinal parasitic infections (IPIs) and to assess the risk factors and clinical features associated with them in children in San Juan y Martinez (SIM), Cuba. Three fresh faecal samples were collected from each child and were examined by direct wet mount, brine flotation, formalin-ether and Kato-Katz techniques. Data relating to demography, source of drinking water, personal hygiene habits and clinical features were also collected Living in the rural area was significantly associated with the highest infection rates (p < 0.01). According to clinical features and laboratory examinations, children with abdominal pain were about four times more likely to have IPIs (OR 4.05, CI, 1.11, 13.18) especially soil-transmitted helminths (STH). We suggest that IPIs, especially STH, in SJM should be strongly suspected in children with abdominal pain from rural areas. Targeted and frequent interventions to control these infections are needed in this municipality.

Extending IPY Data to a Wider Audience

NASA Astrophysics Data System (ADS)

Turrin, M.; Bell, R. E.; Pfirman, S. L.

2010-12-01

Perhaps the most significant IPY contribution to science education was the vast amount of data collected at the polar-regions on Earth systems and processes that was made immediately available to teachers and curriculum developers. Supplementing textbooks with the Internet as an education partner, allowed participating teachers to transform science education through: their use of current data as an integral component of their classroom teaching; their training of students to seek out data as evidence of Earth processes; and their instruction to students on how to validate sources and uses of data. Yet, for every teacher and student who has been part of this successful IPY outreach there are many more who have not been reached, don’t know how to include polar science into their coursework, or don’t comfortably work with data. Our experience with data education projects suggests that to reach the next round of students, teachers, educators and the wider adult population we need to translate this data so it is accessible through carefully constructed activities, simulations, and games. In addition we need to actively seek new partnership and outlet opportunities. The collected measurements tell us that our poles are warming on a human timescale. Using data to tell the story, the unambiguous signal of warming makes it accessible to a much broader audience. Our experience has shown that, for a novice population working with data, the educational effectiveness is significantly enhanced when the signal in the data is strong and the Earth processes are clear. Building upon IPY data and resources, focusing on the Earth’s changing climate, and working with partnerships developed over the last two years, Lamont has put together several new education and outreach collaborations. Our goal is to reach new audiences through: 1) Inventorying, Assessing and Planning - Through an NSF planning grant we are leveraging IPY connections and findings in a Polar Climate Education Partnership. Using polar science as a focus this partnership includes a network of climate science researchers, learning experts and formal and informal education practitioners who will review existing climate resources and begin to develop and test, formal and informal educational resources for an adult population. 2) Linking IPY with Engineering - A new IcePod instrument development grant for an ice sensing system provides a linkage for STEM education. The system will be installed and operated as a data collection system to monitor the changing ice sheets on the New York Air National Guard LC-130 aircraft during flights across the poles. This project provides opportunities for data use, instrument design, technology, alternate science career options, and reaching diverse populations. 3) Linking IPY with mathematics and modeling - Working with West Point Military Academy we are hosting a Climate Curriculum Workshop to develop undergraduate and High School curriculum focused towards mathematics and modeling. Using IPY climate data will allow us to introduce cadets, undergraduates and high school students to the development and testing of simple simulations and models.

us-ipy.org - This website is for sale! - design cascading style sheets

Science.gov Websites

The owner of us-ipy.org is offering it for sale for an asking price of 499 USD! us-ipy.org Related Searches Sedo Logo This webpage was generated by the domain owner using Sedo Domain Parking. Disclaimer mark is not controlled by Sedo nor does it constitute or imply its association, endorsement or

How long after a miscarriage should women wait before becoming pregnant again? Multivariate analysis of cohort data from Matlab, Bangladesh

PubMed Central

DaVanzo, Julie; Hale, Lauren; Rahman, Mizanur

2012-01-01

Objective To determine the optimum interpregnancy interval (IPI) following a miscarriage. Design Multivariate analysis of population-based, prospective data from a demographic surveillance system. Setting Pregnancies in Matlab, Bangladesh, between 1977 and 2008. Participants 9214 women with 10 453 pregnancies that ended in a miscarriage and were followed by another pregnancy outcome. Main outcome measures Outcome of pregnancy following the miscarriage was singleton live birth, stillbirth, miscarriage or induced abortion. For pregnancies that ended in live birth: early neonatal, late neonatal and postneonatal mortality. Results Compared with IPIs of 6–12 months, pregnancies that were conceived ≤3 months after a miscarriage were more likely to result in a live birth and less likely to result in a miscarriage (adjusted relative risk ratio (RRR) 0.70, 95% CI 0.57 to 0.86) or induced abortion (0.50, 0.29 to 0.89). Induced abortions were significantly more likely following IPIs of 18–24 months (2.36, 1.48 to 3.76), 36–48 months (2.73, 1.50 to 4.94), and >48 months (3.32, 1.68 to 2.95), and miscarriages were more likely following IPIs of 12–17 months (1.25, 1.01 to 1.56) and >48 months (1.90, 1.40 to 2.58). No significant effects of IPI duration are seen on the risks of a stillbirth. However, IPIs≤3 months following a miscarriage are associated with significantly higher late neonatal mortality for the infant born at the end of the IPI (adjusted hazard ratio (HR) 1.74, 1.06 to 2.84), and IPIs of 12–18 months are associated with a significantly lower unadjusted risk of postneonatal mortality (0.54, 0.30 to 0.96). Conclusions The shorter the IPI following a miscarriage, the more likely the subsequent pregnancy is to result in a live birth. However, very short IPIs may not be advisable following miscarriages in poor countries like Bangladesh because they are associated with a higher risk of mortality for the infants born after them. PMID:22907047

Reaching out to students across India under IPY

NASA Astrophysics Data System (ADS)

Tiwari, M.; Ravindra, R.

2009-04-01

India is actively involved in the scientific as well as the outreach activities related to IPY with National Centre for Antarctic & Ocean Research (NCAOR) as the national coordinating agency. The purpose of the Indian IPY outreach activities is to educate general public, especially school children, about Poles & specifically about Indian scientific activities that are being carried out there. It becomes an uphill task considering the vast population & area of India. To achieve this, NCAOR in collaboration with WWF-India (World Wide Fund for Nature) is organizing various activities that include competitions such as poster & model making, stamp designing, petition writing etc. for school children. NCAOR has also supplied audio-visual & printed material on polar science for organizing exhibitions that focus on geography, environment, flora, fauna, people & importance of poles along with issues related to poles such as ozone hole, global warming etc. Moreover, a popular book entitled "Story of Antarctica" is published by NCAOR & distributed to students in different states of India. To further give impetus to our outreach efforts & to engage more students, an innovative Soccer Tournament called Sub-Zero Soccer was arranged for College students, which received very enthusiastic response. The main objective is to generate awareness among the youth by engaging them in sports and culture as this is very close to their heart and appeals to them. NCAOR also has a specific student participation program in Indian Antarctic Expeditions & students on return share their experiences with other students through lectures etc. To mark the end of IPY, a whole lot of activities are being planned for the last week of February that would include street plays, lectures, question & answer sessions etc.

Intestinal parasitic infections: Current status and associated risk factors among school aged children in an archetypal African urban slum in Nigeria.

PubMed

Gyang, Vincent P; Chuang, Ting-Wu; Liao, Chien-Wei; Lee, Yueh-Lun; Akinwale, Olaoluwa P; Orok, Akwaowo; Ajibaye, Olusola; Babasola, Ajayi J; Cheng, Po-Ching; Chou, Chia-Mei; Huang, Ying-Chieh; Sonko, Pasaiko; Fan, Chia-Kwung

2017-06-22

Intestinal parasitic infections (IPIs) among school aged children (SAC) in Nigeria remains endemic, hence the need for regular surveillance to attract the attention of policy makers. This cross-sectional study investigated the current prevalence and factors associated with intestinal parasitic infections among school aged children in an urban slum of Lagos City, Nigeria. Single stool samples from 384 school aged children (188 boys and 196 girls) were examined by employing Merthiolate-iodine-formaldehyde concentration (MIFC) and Kato-Katz methods. Demographic characteristics and risk factors were obtained by questionnaires investigation. The overall prevalence was 86.2% in school children, out of them 39.1% had polyparasitism. IPIs showed the highest to the lowest prevalence of 62% (238/384), 25% (97/384), 12.3% (47/384), 11.8% (45/384), 9.9% (38/384), 8.4% (32/384), 3.4% (13/384), and 0.5% (2/384) found in Ascaris lumbricoides, Entamoeba histolytica/dispar, Giardia duodenalis, Endolimax nana, Entamoeba coli, Trichuris trichiura, Blastocystis hominis, and hookworm infections, respectively. MIFC technique showed superiority to Kato-Katz technique in the detection of IPIs (p < 0.0001). Drinking untreated water was a significant risk factor for these school aged children in acquiring protozoan infections after multivariate adjustment (OR = 1.86, 95% CI = 1.08-3.20, p = 0.02). Intestinal parasitic infections are very severe among school aged children in the urban slums, thus regular mass de-worming programs, health education, and the provision of safe drinking water is recommended to combat IPIs among the school aged children. Copyright © 2017. Published by Elsevier B.V.

Interpregnancy interval following miscarriage and adverse pregnancy outcomes: systematic review and meta-analysis.

PubMed

Kangatharan, Chrishny; Labram, Saffi; Bhattacharya, Sohinee

2017-03-01

A short interpregnancy interval (IPI) following a delivery is believed to be associated with adverse outcomes in the next pregnancy. The optimum IPI following miscarriage is controversial. Based on a single large-scale study in Latin and South America, the World Health Organization recommends delaying pregnancy for 6 months after a miscarriage to achieve optimal outcomes in the next pregnancy. Our aim was to determine if a short IPI (<6 months) following miscarriage is associated with adverse outcomes in the next pregnancy. Studies were retrieved from MEDLINE, Embase and Pubmed, with no time and language restrictions. The search strategy used a combination of Medical Subject Headings terms for miscarriage, IPI and adverse outcomes. Bibliographies of the retrieved articles were also searched by hand. All studies including women with at least one miscarriage, comparing subsequent adverse pregnancy outcomes for IPIs of less than and more than 6 months were included. Two independent reviewers screened titles and abstracts for inclusion. Characteristics of the studies were extracted and quality assessed using Critical Appraisal Skills Programme criteria. A systematic review and meta-analysis were conducted to compare short (<6 months) versus long (>6 months) IPI following miscarriage in terms of risk of further miscarriage, preterm birth, stillbirth, pre-eclampsia and low birthweight babies in the subsequent pregnancy. Review Manager 5.3 was used for conducting meta-analyses. Sixteen studies including 1 043 840 women were included in the systematic review and data from 10 of these were included in one or more meta-analyses (977 972 women). With an IPI of less than 6 months, the overall risk of further miscarriage (Risk ratio (RR) 0.82 95% CI 0.78, 0.86) and preterm delivery (RR 0.79 95% CI 0.75, 0.83) were significantly reduced. The pooled risks of stillbirth (RR 0.88 95% CI 0.76, 1.02); low birthweight (RR 1.05 95% CI 0.48, 2.29) and pre-eclampsia (RR 0.95 95% CI 0.88, 1.02) were not affected by IPI. Similar findings were obtained in subgroup analyses when IPI of <6 months was compared with IPI of 6-12 months and >12 months. This is the first systematic review and meta-analysis providing clear evidence that an IPI of less than 6 months following miscarriage is not associated with adverse outcomes in the next pregnancy. This information may be used to revise current guidance. © The Author 2016. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com

NCCN-IPI score-independent prognostic potential of pretreatment uric acid levels for clinical outcome of diffuse large B-cell lymphoma patients

PubMed Central

Prochazka, Katharina T; Melchardt, Thomas; Posch, Florian; Schlick, Konstantin; Deutsch, Alexander; Beham-Schmid, Christine; Weiss, Lukas; Gary, Thomas; Neureiter, Daniel; Klieser, Eckhard; Greil, Richard; Neumeister, Peter; Egle, Alexander; Pichler, Martin

2016-01-01

Background: Blood-based parameters are gaining increasing interest as potential prognostic biomarkers in patients with diffuse large B-cell lymphoma (DLBCL). The aim of this study was to comprehensively evaluate the prognostic significance of pretreatment plasma uric acid levels in patients with newly diagnosed DLBCL. Methods: The clinical course of 539 DLBCL patients, diagnosed and treated between 2004 and 2013 at two Austrian high-volume centres with rituximab-based immunochemotherapy was evaluated retrospectively. The prognostic influence of uric acid on overall survival (OS) and progression-free survival (PFS) were studied including multi-state modelling, and analysis of conditional survival. Results: Five-year OS and PFS were 50.4% (95% CI: 39.2–60.6) and 44.0% (33.4–54.0) in patients with uric acid levels above the 75th percentile of the uric acid distribution (Q3, cut-off: 6.8 mg dl−1), and 66.2% (60.4–71.5) and 59.6% (53.7–65.0%) in patients with lower levels (log-rank P=0.002 and P=0.0045, respectively). In univariable time-to-event analysis, elevated uric acid levels were associated with a worse PFS (hazard ratio (HR) per 1 log increase in uric acid 1.47, 95% CI: 1.10–1.97, P=0.009) and a worse OS (HR=1.60, 95% CI: 1.16–2.19, P=0.004). These associations prevailed upon multivariable adjustment for the NCCN-IPI score. Uric acid levels significantly improved the predictive performance of the R-IPI and NCCN-IPI scores, and in multi-state analysis, it emerged as a highly significant predictor of an increased risk of death without developing recurrence (transition-HR=4.47, 95% CI: 2.17–9.23, P<0.0001). Conclusions: We demonstrate that elevated uric acid levels predict poor long-term outcomes in DLBCL patients beyond the NCCN-IPI risk index. PMID:27764838

Photonic simulation of topological superconductor edge state and zero-energy mode at a vortex

PubMed Central

Tan, Wei; Chen, Liang; Ji, Xia; Lin, Hai-Qing

2014-01-01

Photonic simulations of quantum Hall edge states and topological insulators have inspired considerable interest in recent years. Interestingly, there are theoretical predictions for another type of topological states in topological superconductors, but debates over their experimental observations still remain. Here we investigate the photonic analogue of the px + ipy model of topological superconductor. Two essential characteristics of topological superconductor, particle-hole symmetry and px + ipy pairing potentials, are well emulated in photonic systems. Its topological features are presented by chiral edge state and zero-energy mode at a vortex. This work may fertilize the study of photonic topological states, and open up the possibility for emulating wave behaviors in superconductors. PMID:25488408

The Predictive Value of Integrated Pulmonary Index after Off-Pump Coronary Artery Bypass Grafting: A Prospective Observational Study.

PubMed

Fot, Evgenia V; Izotova, Natalia N; Yudina, Anjelika S; Smetkin, Aleksei A; Kuzkov, Vsevolod V; Kirov, Mikhail Y

2017-01-01

The early warning scores may increase the safety of perioperative period. The objective of this study was to assess the diagnostic and predictive role of Integrated Pulmonary Index (IPI) after off-pump coronary artery bypass grafting (OPCAB). Forty adult patients undergoing elective OPCAB were enrolled into a single-center prospective observational study. We assessed respiratory function using IPI that includes oxygen saturation, end-tidal CO 2 , respiratory rate, and pulse rate. In addition, we evaluated blood gas analyses and hemodynamics, including ECG, invasive arterial pressure, and cardiac index. The measurements were performed after transfer to the intensive care unit, after spontaneous breathing trial and at 2, 6, 12, and 18 h after extubation. The value of IPI registered during respiratory support correlated weakly with cardiac index (rho = 0.4; p  = 0.04) and ScvO 2 (rho = 0.4, p  = 0.02). After extubation, IPI values decreased significantly, achieving a minimum by 18 h. The IPI value ≤9 at 6 h after extubation was a predictor of complicated early postoperative period (AUC = 0.71; p  = 0.04) observed in 13 patients. In off-pump coronary surgery, the IPI decreases significantly after tracheal extubation and may predict postoperative complications.

Molecular Simulation of Ionic Polyimides and Composites with Ionic Liquids as Gas-Separation Membranes.

PubMed

Abedini, Asghar; Crabtree, Ellis; Bara, Jason E; Turner, C Heath

2017-10-24

Polyimides are at the forefront of advanced membrane materials for CO 2 capture and gas-purification processes. Recently, ionic polyimides (i-PIs) have been reported as a new class of condensation polymers that combine structural components of both ionic liquids (ILs) and polyimides through covalent linkages. In this study, we report CO 2 and CH 4 adsorption and structural analyses of an i-PI and an i-PI + IL composite containing [C 4 mim][Tf 2 N]. The combination of molecular dynamics (MD) and grand canonical Monte Carlo (GCMC) simulations is used to compute the gas solubility and the adsorption performance with respect to the density, fractional free volume (FFV), and surface area of the materials. Our results highlight the polymer relaxation process and its correlation to the gas solubility. In particular, the surface area can provide meaningful guidance with respect to the gas solubility, and it tends to be a more sensitive indicator of the adsorption behavior versus only considering the system density and FFV. For instance, as the polymer continues to relax, the density, FFV, and pore-size distribution remain constant while the surface area can continue to increase, enabling more adsorption. Structural analyses are also conducted to identify the nature of the gas adsorption once the ionic liquid is added to the polymer. The presence of the IL significantly displaces the CO 2 molecules from the ligand nitrogen sites in the neat i-PI to the imidazolium rings in the i-PI + IL composite. However, the CH 4 molecules move from the imidazolium ring sites in the neat i-PI to the ligand nitrogen atoms in the i-PI + IL composite. These molecular details can provide critical information for the experimental design of highly selective i-PI materials as well as provide additional guidance for the interpretation of the simulated adsorption systems.

IPY: Engaging Antarctica: Bringing Antarctic Geoscience to the Public Through a NOVA Documentary and an Innovative Flexible Exhibit for Informal Science Education Venues

NASA Astrophysics Data System (ADS)

Rack, F.; Diamond, J.; Levy, R.; Berg, M.; Dahlman, L.; Jackson, J.

2006-12-01

IPY: Engaging Antarctica is an informal science education project designed to increase the general public's understanding of scientific research conducted in Antarctica. The project focuses specifically on the multi- national, NSF-funded Antarctic Drilling Project (ANDRILL). The ANDRILL project is the newest geological drilling program in an ongoing effort to recover stratigraphic records from Antarctica. ANDRILL's primary objectives are to investigate Antarctica's role in global environmental change over the past 65 million years and to better understand its future response to global changes. Additionally, through ANDRILL's Research Immersion for Science Educators program (ARISE), 12 science educators from four countries will work on science research teams in Antarctica and produce educational materials that feature Antarctic geoscience. The Engaging Antarctica project will produce both a NOVA television documentary and an innovative informal learning exhibit. The documentary, Antarctica's Icy Secrets, will provide a geological perspective on how Antarctica continues to play a major role in affecting global climate by altering ocean currents and sea levels. The learning exhibit, one that blends standards- and inquiry-based learning with the latest information technologies, is coined the Flexhibit. The Engaging Antarctica Flexhibit will provide a digital package of high resolution images for banners as well as learning activities and ideas for exhibit stations that can be implemented by youth groups. Flexhibit images will feature ANDRILL scientists at work, and audio files, available as podcasts, will tell scientists' stories in their own words, speaking directly to the public about the joys and challenges of Antarctic geological research.

Intestinal Parasitic Infections among Prison Inmates and Tobacco Farm Workers in Shewa Robit, North-Central Ethiopia

PubMed Central

Mamo, Hassen

2014-01-01

Background Intestinal parasitic infections (IPIs) particularly soil-transmitted helminthiasis (STH) and schistosomiasis are among neglected tropical diseases (NTDs) globally. Apart from being associated with anemia, malabsorption and retarded cognitive development these diseases are complicating the clinical picture of more serious infections like HIV, TB and malaria. Renewed and up-to-date information on the epidemiology of IPIs in more vulnerable groups such as irrigated-farm workers and prisoners would significantly contribute towards improving the health condition of such at-risk groups. Methods A cross-sectional survey was conducted to determine the prevalence of IPIs among prison inmates and tobacco farm workers in Shewa-Robit, north-central Ethiopia in November 2008. A total of 236 fecal samples were examined microscopically to detect helminths and/or protozoa using direct-smear and formol-ether concentration methods. Results Overall, 8 intestinal parasite species have been recovered singly or in combinations from 146 (61.8 %) samples. The prevalence in prison population (88/121 = 72.7%) was significantly higher than that in tobacco farm (58/115 = 50.4%). There were no significant differences in the prevalence of IPI by most socio-demographics. Except for hookworm there was no significant difference in parasite prevalence between different age-groups though the frequency of individual parasites slightly varied between the age-groups. Multivariate logistic regression analysis showed that inmates were more likely to acquire IPIs than tobacco-farm workers (Odds Ratio (OR)  = 2.62, 95% confidence interval (CI)  = 1.52–4.5). In addition, participants who did not report past treatment for IPIs were more likely to acquire IPIs than participants who self-reported treatment for IPIs in the past twelve months (OR = 3.25, 95% CI = 1.75–6.06). All other socio-demographics were not significantly associated with IPIs in univariate analysis. Entamoeba histolytica/dispar/moshkovskii was the most frequently encountered species in both study sites accounting for 48.8 and 51.7 percent of the positives in prison and tobacco farm population respectively. Other intestinal parasites detected, with slight variation in prevalence in the two study areas, were hookworm, Ascaris lumbricoides, Trichuris trichiura, Schistosoma mansoni, Strongyloides stercolaris, Hymenolepis nana and Taenia sp. 35.5 and 33.0 percent of the total positive cases were mixed infections in Shewa Robit prison and tobacco farm, respectively. Conclusion The results show that IPIs are common health problems in the studied populations. PMID:24926687

Prognostic impact of sarcopenia in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone.

PubMed

Go, Se-Il; Park, Mi Jung; Song, Haa-Na; Kim, Hoon-Gu; Kang, Myoung Hee; Lee, Hyang Rae; Kim, Yire; Kim, Rock Bum; Lee, Soon Il; Lee, Gyeong-Won

2016-12-01

Sarcopenia is known to be related to an increased risk of chemotherapy toxicity and to a poor prognosis in patients with malignancy. We assessed the prognostic role of sarcopenia in patients with diffuse large B-cell lymphoma (DLBCL). In total, 187 consecutive patients with DLBCL treated with induction rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) immunochemotherapy were reviewed. Sarcopenia was defined as the lowest sex-specific quartile of the skeletal muscle index, calculated by dividing the pectoralis muscle area by the height. Clinical outcomes were compared between the sarcopenic and non-sarcopenic groups. A nomogram was constructed from the Cox regression model for overall survival (OS). Treatment-related mortality (21.7 vs. 5.0%, P  = 0.002) and early discontinuation of treatment (32.6 vs. 14.9%, P  = 0.008) were more common in the sarcopenic group than in the non-sarcopenic group. The 5 year progression-free survival (PFS) rates were 35.3% in the sarcopenic group and 65.8% in the non-sarcopenic group ( P  < 0.001). The 5 year OS rates were 37.3% in the sarcopenic group and 68.1% in the non-sarcopenic group ( P  < 0.001). Sarcopenia and the five variables of the International Prognostic Index (IPI) were independent prognostic factors in a multivariate analysis for PFS and OS and were used to construct the nomogram. The calibration plot showed good agreement between the nomogram predictions and actual observations. The c index of the nomogram (0.80) was higher than those of other prognostic indices (IPI, 0.77, P  = 0.009; revised-IPI, 0.74, P  < 0.001; National Comprehensive Cancer Network-IPI, 0.77, P  = 0.062). Sarcopenia is associated with intolerance to standard R-CHOP chemotherapy as well as a poor prognosis. Moreover, sarcopenia itself can be included in prognostic models in DLBCL.

Design and usability evaluation of user-centered and visual-based aids for dietary food measurement on mobile devices in a randomized controlled trial.

PubMed

Liu, Ying-Chieh; Chen, Chien-Hung; Lee, Chien-Wei; Lin, Yu-Sheng; Chen, Hsin-Yun; Yeh, Jou-Yin; Chiu, Sherry Yueh-Hsia

2016-12-01

We designed and developed two interactive apps interfaces for dietary food measurements on mobile devices. The user-centered designs of both the IPI (interactive photo interface) and the SBI (sketching-based interface) were evaluated. Four types of outcomes were assessed to evaluate the usability of mobile devices for dietary measurements, including accuracy, absolute weight differences, and the response time to determine the efficacy of food measurements. The IPI presented users with images of pre-determined portion sizes of a specific food and allowed users to scan and then select the most representative image matching the food that they were measuring. The SBI required users to relate the food shape to a readily available comparator (e.g., credit card) and scribble to shade in the appropriate area. A randomized controlled trial was conducted to evaluate their usability. A total of 108 participants were randomly assigned into the following three groups: the IPI (n=36) and SBI (n=38) experimental groups and the traditional life-size photo (TLP) group as the control. A total of 18 types of food items with 3-4 different weights were randomly selected for assessment by each type. The independent Chi-square test and t-test were performed for the dichotomous and continuous variable analyses, respectively. The total accuracy rates were 66.98%, 44.15%, and 72.06% for the IPI, SBI, and TLP, respectively. No significant difference was observed between the IPI and TLP, regardless of the accuracy proportion or weight differences. The SBI accuracy rates were significantly lower than the IPI and TLP accuracy rates, especially for several spooned, square cube, and sliced pie food items. The time needed to complete the operation assessment by the user was significantly lower for the IPI than for the SBI. Our study corroborates that the user-centered visual-based design of the IPI on a mobile device is comparable the TLP in terms of the usability for dietary food measurements. However, improvements are needed because both the IPI and TLP accuracies associated with some food shapes were lower than 60%. The SBI is not yet a viable aid. This innovative alternative required further improvements to the user interface. Copyright © 2016 Elsevier Inc. All rights reserved.

Phase II study of the immune-checkpoint inhibitor ipilimumab plus dacarbazine in Japanese patients with previously untreated, unresectable or metastatic melanoma.

PubMed

Yamazaki, N; Uhara, H; Fukushima, S; Uchi, H; Shibagaki, N; Kiyohara, Y; Tsutsumida, A; Namikawa, K; Okuyama, R; Otsuka, Y; Tokudome, T

2015-11-01

Ipilimumab (IPI), a monoclonal antibody against immune-checkpoint receptor cytotoxic T lymphocyte antigen-4, is designed to enhance antitumor T cell function. IPI 10 mg/kg plus dacarbazine (DTIC) significantly improved overall survival in a phase 3 study involving predominantly Caucasian patients, with an adverse event (AE) profile similar to that of IPI monotherapy. We conducted a single-arm, phase 2 study to evaluate the safety and efficacy of IPI plus DTIC in Japanese patients. Previously untreated patients with unresectable stage III or IV melanoma received IPI 10 mg/kg plus DTIC 850 mg/m(2) every 3 weeks for four doses (q3w × 4), followed by DTIC q3w × 4 and then IPI every 12 weeks until disease progression or intolerable toxicity. All 15 treated patients reported drug-related AEs, the most common of which were increases in alanine aminotransferase (n = 12, 80 %) and aspartate aminotransferase (n = 11, 73 %). Treatment-related serious AEs were reported in 11 (73 %) patients. Nine patients (60 %) discontinued treatment due to drug-related toxicities. Immune-related AEs (irAEs) were reported in 14 patients (93 %). The most frequent irAEs were liver (n = 12, 80 %) and skin (n = 10, 67 %) toxicities. Five deaths were reported; all were caused by progressive disease. Efficacy evaluation showed one complete response, one partial response and four patients with stable disease. Best overall response rate was 13 % (2/15), and the disease control rate was 40 % (6/15). The study was terminated early due to frequent, high-grade liver toxicities. IPI 10 mg/kg plus DTIC 850 mg/m(2) was not considered tolerable in the Japanese patient population. ClinicalTrials.gov identifier: NCT01681212.

A phase 1 study of the heat shock protein 90 inhibitor retaspimycin hydrochloride (IPI-504) in patients with gastrointestinal stromal tumors or soft tissue sarcomas

PubMed Central

Wagner, Andrew J.; Chugh, Rashmi; Rosen, Lee S.; Morgan, Jeffrey A.; George, Suzanne; Gordon, Michael; Dunbar, Joi; Normant, Emmanuel; Grayzel, David; Demetri, George D.

2015-01-01

Purpose Heat shock protein 90 (Hsp90) is required for the proper folding, function, and stability of various client proteins, two of which (KIT and PDGFRα) are critical in the pathogenesis and progression of gastrointestinal stromal tumors (GIST). This phase 1 study investigated the safety and maximum tolerated dose (MTD) of retaspimycin hydrochloride (IPI-504), a novel potent and selective Hsp90 inhibitor, in patients with metastatic and/or unresectable GIST or other soft-tissue sarcomas (STS). Experimental Design IPI-504 was administered intravenously at doses ranging from 90 to 500 mg/m2 twice weekly for 2 weeks on/1 week off. Safety, pharmacokinetic, and pharmacodynamic profiles were determined. Response was assessed by Response Evaluation Criteria for Solid Tumors (RECIST) 1.0 and optionally via 18-fluorodeoxyglucose positron emission tomography (18-FDG-PET) imaging. Results Fifty-four patients received IPI-504; 37 with GIST and 17 with other STS. The MTD was 400 mg/m2 twice weekly for 2 weeks on/1 week off. Common related adverse events were fatigue (59%), headache (44%), and nausea (43%). Exposure to IPI-504, 17-AAG, and 17-AG increased with IPI-504 dose. Stable disease (SD) was observed in 70% (26/37) of patients with GIST and 59% (10/17) of patients with STS. There was one confirmed partial response (PR) in a patient with GIST and one PR in a patient with liposarcoma. Metabolic partial responses occurred in 11/29 (38%) of GIST patients. Conclusions In this study of advanced GIST or other STS, IPI-504 was generally well-tolerated with some evidence of anti-tumor activity, serving as a clinical proof-of-concept that HSP90 inhibition remains a promising strategy. PMID:24045182

Survey and Chase: A New Method of Observations For The Michigan Orbital Debris Survey Telescope (MODEST)

NASA Technical Reports Server (NTRS)

Abercromby, Kira J.; Seitzer, Patrick; Rodriquez, Heather M.; Barker, Edwin S.; Matney, Mark J.

2006-01-01

For more than 40 years astronauts have been observing Earth, taking photographs or digital images from their spacecraft. Today, a robust program of observation from the International Space Station (ISS) has yielded hundreds of thousands of images of the Earth s surface collected since 2001. Seeing Earth through the eyes of an astronaut is exciting to the general public, and the images are popular in classrooms. Because the ISS has an orbital inclination of 51.6 degrees (the north-south limits of the orbit are at 51.6 degrees latitude), high latitude observations are common. Some of the most striking images collected include views of polar phenomena. Astronauts routinely pass above brilliant red and green aurora; view high, wispy clouds at the top of the atmosphere; or look down on glaciers and floating ice rafts. These images, framed and captured by humans, are easily interpreted by students and teachers. Astronaut observations provide a way to visualize complicated polar phenomena and communicate about them to students of all ages. Over the next two years, astronauts aboard the ISS will formally focus their observations on polar phenomena as participants in the International Polar Year (IPY). Imagery acquisition from the ISS will be coordinated with other IPY scientists staging studies and field campaigns on the ground. The imagery collected from the ISS will be cataloged and served on NASA s web-based database of images, http://eol.jsc.nasa.gov . The website allows investigators, students and teachers to search through the imagery, assemble image datasets, and download the imagery and the metadata. We display some of the most spectacular examples of polar imagery and demonstrate NASA s database of astronaut images of Earth.

CHOP or THP-COP regimens in the treatment of newly diagnosed peripheral T-cell lymphoma, not otherwise specified: a comparison of doxorubicin and pirarubicin.

PubMed

Shibata, Yuhei; Hara, Takeshi; Kasahara, Senji; Yamada, Toshiki; Sawada, Michio; Mabuchi, Ryoko; Matsumoto, Takuro; Nakamura, Nobuhiko; Nakamura, Hiroshi; Ninomiya, Soranobu; Kitagawa, Junichi; Kanemura, Nobuhiro; Kito, Yusuke; Goto, Naoe; Miyazaki, Tatsuhiko; Takami, Tsuyoshi; Takeuchi, Tamotsu; Shimizu, Masahito; Tsurumi, Hisashi

2017-06-01

The CHOP regimen consisting of cyclophosphamide, doxorubicin (DOX), vincristine and prednisolone has been the most used regimen for peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). Pirarubicin [tetrahydropyranyladriamycin (THP)], a derivative of DOX, is an anthracycline with reportedly less cardiotoxicity than DOX. Here, we confirmed the efficacy of THP-COP using THP instead of DOX in the treatment of PTCL-NOS. The study protocol employed a retrospective, consecutive entry design. We retrospectively analysed 56 patients with PTCL-NOS who had received THP-COP or CHOP. These regimens were performed every 21 days. Twenty-nine patients received THP-COP, and 27 received CHOP. There were no significant differences in known prognostic factors, including in the International Prognostic Index (IPI) and the prognostic index for T-cell lymphoma (PIT), between the two groups. Complete remission rates in patients with THP-COP and CHOP were 52% in both groups; the 3-year overall survival (OS) rates were 67% and 52% (p = 0.074), and the 3-year progression-free survival (PFS) rates were 51% and 29% (p = 0.070), respectively. In patients with low IPI (low or low-intermediate), THP-COP had significantly better 3-year OS (100% vs. 64%; p < 0.001) and 3-year PFS (75% vs. 33%; p < 0.05) than CHOP. Similar differences between THP-COP and CHOP were observed in patients with a low PIT (groups 1 or 2). Our study showed that THP-COP produced results equivalent to CHOP regarding efficacy and safety in patients with PTCL-NOS. In patients with low IPI or PIT, THP-COP resulted in significantly better prognosis. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

International Polar Year: Science at the Ends of the Earth

USGS Publications Warehouse

,

2007-01-01

In response to unprecedented changes in the fragile polar regions of our planet, the International Polar Year (IPY) 2007-2008 will encompass many scientific studies designed to improve our understanding of polar change and its effects on Earth's ecosystems and people. For 2 years, U.S. Geological Survey (USGS) researchers will don arctic gear and join scientists from more than 60 countries to conduct coordinated research and analysis in the Arctic and Antarctic. Polar regions play a critical role in the global climate system-and changing conditions in these often remote areas greatly affect biological, atmospheric, and human systems around the world. In the 50 years since the last IPY, scientists have seen that Antarctic ice shelves and glaciers worldwide are thinning and retreating, permafrost is thawing, and Arctic sea-ice cover is decreasing. The loss of sea-ice cover adversely affects marine mammal populations and leaves coastal Alaskan villages vulnerable to winter storm erosion. Thawing permafrost threatens the integrity of roads, buildings, and other vulnerable infrastructure and affects the mobility of local populations.

Compiled visualization with IPI method for analysing of liquid liquid mixing process

NASA Astrophysics Data System (ADS)

Jasikova, Darina; Kotek, Michal; Kysela, Bohus; Sulc, Radek; Kopecky, Vaclav

2018-06-01

The article deals with the research of mixing process using visualization techniques and IPI method. Characteristics of the size distribution and the evolution of two liquid-liquid phase's disintegration were studied. A methodology has been proposed for visualization and image analysis of data acquired during the initial phase of the mixing process. IPI method was used for subsequent detailed study of the disintegrated droplets. The article describes advantages of usage of appropriate method, presents the limits of each method, and compares them.

Indian Contribution to IPY Outreach Activities

NASA Astrophysics Data System (ADS)

Tiwari, M.; Ravindra, R.

2007-12-01

India is involved in a major way in both the aspects, i.e. scientific as well as outreach activities, of the International Polar Year (IPY) 2007-2008. National Centre for Antarctic & Ocean Research (NCAOR, under the Ministry of Earth Sciences, Government of India) is acting as the national coordinating agency. The launching of the Indian chapter of the IPY 2007-2008 took place at NCAOR and parallely at Jawaharlal Nehru National University (JNU), New Delhi on 1st March 2007. Two Indian scientific proposals have been endorsed by IPY, which are Project id. 70 and Project id. 129. Simultaneously, India is actively involved in the outreach activities related to IPY. NCAOR had sponsored the visit of two college students to Antarctica during the 25th Indian Antarctic Expedition (IAE). A series of lectures were delivered by one of them at more than twenty schools & colleges in the rural & suburban areas of Indian state of Maharashtra regarding the wonders of Antarctica to educate the general public and popularize polar science. NCAOR is the only Indian institute that has the capability to store and sample Antarctic ice core with special Cold Room facility that is maintained at -20°C. Students from several schools and colleges and scientists/visitors from various Indian institutes/foreign countries have visited NCAOR to get first hand experience of polar research. NCAOR has also collaborated with WWF-India (World Wide Fund for Nature) for carrying out the outreach activities to schools throughout the vast expanses of India. In this regard a calendar of event was released on 1st March 2007, which lists various competitions and activities that will be held during 2007-2008. It includes competitions such as poster & model making, stamp designing, petition writing etc. for school children. The first competition, poster making & slogan writing, was held at New Delhi on April 10, 2007 and prizes were distributed by the H'ble Minister of Science & Technology and Earth Sciences on the Earth Day. Further under the aegis of IPY 2007-2008, a 14 year old Indian student from Father Agnel School, New Delhi was selected by the Canadian organization, Student On Ice, for their annual Arctic expedition that was held from August 2nd to 17th, 2007. The participants were accompanied by an international team of polar scientists, experts and educators. The participant on return will share their experiences with fellow students to introduce them to a world unknown to them. Further, NCAOR has supplied audio-visual & printed material on polar science to Nehru Science Centre (unit of National council of Science Museums, Ministry of Culture, Government of India) which is organizing exhibitions on the theme ¡§The Story of Poles¡¨ focusing on geography, environment, flora, fauna, people & importance of poles along with issues related to poles such as ozone hole, global warming etc. the exhibition will consist of graphical panels, 3D interactive exhibits, animations, charts, 3D models, computer kiosks etc. Financial sponsorship has been extended to Goa Science Centre, India & Geographical Society of the Northeast Hill Region, India for popularizing polar science and other aims of IPY to general public. Moreover, under the "Popular Book Series" initiative of the Ministry of Earth Sciences, a book entitled "Story of Antarctica" is under publication by NCAOR. Similar books on "Story of the Oceans" and "Glaciers - The Rivers of Ice" have already been published & distributed to students in different states of India. Further details can be had at the National Centre for Antarctic and Ocean Research website (www.ncaor.gov.in).

IPY STEM Polar Connections Links Teachers with the Global Relevance of the High Latitudes

NASA Astrophysics Data System (ADS)

Brigham-Grette, J.; Sternheim, M.; Bradley, R.; Caissie, B.; Snyder, R.; Devlin, K.; Silver, M.; Hargraves, H.

2008-12-01

IPY STEM Polar Connections is a curriculum development and professional development program involving a summer residential institute at UMass-Amherst and academic year, on-line communication for teachers involved in the professional development of colleagues. The project produces and disseminates a range of curriculum modules related to the Polar regions and climate change. The purpose of the summer institutes (2008 and 2009) is to test the modules and prepare teachers to disseminate selected materials in workshops in their districts, in their states and nationally. The institute agenda balanced content presentations with hands-on activities for use by teachers with diverse backgrounds and classroom settings. Power point presentations and accompanying flash videos are all posted on our website along with teacher guides and student handouts. Most of the materials were designed to be adaptable to a range of inquiry-based levels. The teachers shared their own experiences with dissemination in rounds of focus groups. Pre institute and post institute surveys confirmed our success in increasing the personal knowledge base of the teachers despite the fact that most were veteran teachers. The main outcomes of participation were the development of relationships with other teachers, enhanced knowledge of earth system science and inspiration for introducing the materials to their students. Many did see funding, time and state frameworks as potential barriers to including materials in their classrooms.

Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones.

PubMed

Jeannot, Frédéric; Taillier, Thomas; Despeyroux, Pierre; Renard, Stéphane; Rey, Astrid; Mourez, Michaël; Poeverlein, Christoph; Khichane, Imène; Perrin, Marc-Antoine; Versluys, Stéphanie; Stavenger, Robert A; Huang, Jianzhong; Germe, Thomas; Maxwell, Anthony; Cao, Sha; Huseby, Douglas L; Hughes, Diarmaid; Bacqué, Eric

2018-04-26

In our quest for new antibiotics able to address the growing threat of multidrug resistant infections caused by Gram-negative bacteria, we have investigated an unprecedented series of non-quinolone bacterial topoisomerase inhibitors from the Sanofi patrimony, named IPYs for imidazopyrazinones, as part of the Innovative Medicines Initiative (IMI) European Gram Negative Antibacterial Engine (ENABLE) organization. Hybridization of these historical compounds with the quinazolinediones, a known series of topoisomerase inhibitors, led us to a novel series of tricyclic IPYs that demonstrated potential for broad spectrum activity, in vivo efficacy, and a good developability profile, although later profiling revealed a genotoxicity risk. Resistance studies revealed partial cross-resistance with fluoroquinolones (FQs) suggesting that IPYs bind to the same region of bacterial topoisomerases as FQs and interact with at least some of the keys residues involved in FQ binding.

A new extranodal scoring system based on the prognostically relevant extranodal sites in diffuse large B-cell lymphoma, not otherwise specified treated with chemoimmunotherapy.

PubMed

Hwang, Hee Sang; Yoon, Dok Hyun; Suh, Cheolwon; Huh, Jooryung

2016-08-01

Extranodal involvement is a well-known prognostic factor in patients with diffuse large B-cell lymphomas (DLBCL). Nevertheless, the prognostic impact of the extranodal scoring system included in the conventional international prognostic index (IPI) has been questioned in an era where rituximab treatment has become widespread. We investigated the prognostic impacts of individual sites of extranodal involvement in 761 patients with DLBCL who received rituximab-based chemoimmunotherapy. Subsequently, we established a new extranodal scoring system based on extranodal sites, showing significant prognostic correlation, and compared this system with conventional scoring systems, such as the IPI and the National Comprehensive Cancer Network-IPI (NCCN-IPI). An internal validation procedure, using bootstrapped samples, was also performed for both univariate and multivariate models. Using multivariate analysis with a backward variable selection, we found nine extranodal sites (the liver, lung, spleen, central nervous system, bone marrow, kidney, skin, adrenal glands, and peritoneum) that remained significant for use in the final model. Our newly established extranodal scoring system, based on these sites, was better correlated with patient survival than standard scoring systems, such as the IPI and the NCCN-IPI. Internal validation by bootstrapping demonstrated an improvement in model performance of our modified extranodal scoring system. Our new extranodal scoring system, based on the prognostically relevant sites, may improve the performance of conventional prognostic models of DLBCL in the rituximab era and warrants further external validation using large study populations.

A decision support system and rule-based algorithm to augment the human interpretation of the 12-lead electrocardiogram.

PubMed

Cairns, Andrew W; Bond, Raymond R; Finlay, Dewar D; Guldenring, Daniel; Badilini, Fabio; Libretti, Guido; Peace, Aaron J; Leslie, Stephen J

The 12-lead Electrocardiogram (ECG) has been used to detect cardiac abnormalities in the same format for more than 70years. However, due to the complex nature of 12-lead ECG interpretation, there is a significant cognitive workload required from the interpreter. This complexity in ECG interpretation often leads to errors in diagnosis and subsequent treatment. We have previously reported on the development of an ECG interpretation support system designed to augment the human interpretation process. This computerised decision support system has been named 'Interactive Progressive based Interpretation' (IPI). In this study, a decision support algorithm was built into the IPI system to suggest potential diagnoses based on the interpreter's annotations of the 12-lead ECG. We hypothesise semi-automatic interpretation using a digital assistant can be an optimal man-machine model for ECG interpretation. To improve interpretation accuracy and reduce missed co-abnormalities. The Differential Diagnoses Algorithm (DDA) was developed using web technologies where diagnostic ECG criteria are defined in an open storage format, Javascript Object Notation (JSON), which is queried using a rule-based reasoning algorithm to suggest diagnoses. To test our hypothesis, a counterbalanced trial was designed where subjects interpreted ECGs using the conventional approach and using the IPI+DDA approach. A total of 375 interpretations were collected. The IPI+DDA approach was shown to improve diagnostic accuracy by 8.7% (although not statistically significant, p-value=0.1852), the IPI+DDA suggested the correct interpretation more often than the human interpreter in 7/10 cases (varying statistical significance). Human interpretation accuracy increased to 70% when seven suggestions were generated. Although results were not found to be statistically significant, we found; 1) our decision support tool increased the number of correct interpretations, 2) the DDA algorithm suggested the correct interpretation more often than humans, and 3) as many as 7 computerised diagnostic suggestions augmented human decision making in ECG interpretation. Statistical significance may be achieved by expanding sample size. Copyright © 2017 Elsevier Inc. All rights reserved.

Arctic Research and Writing: A Lasting Legacy of the International Polar Year

ERIC Educational Resources Information Center

Englert, Karl; Coon, Brian; Hinckley, Matt; Pruis, Matt

2009-01-01

Recently, senior-level physics students joined thousands of scientists from over 60 nations to examine a wide range of physical, biological, and social research topics as part of the International Polar Year (IPY). Through a National Science Foundation (NSF)-funded research project, these students applied physics concepts to the study of Arctic…

Community Needs Assessment and Portal Prototype Development for an Arctic Spatial Data Infrastructure (ASDI): A Contribution to an IPY Data Cyberinfrastructure

NASA Astrophysics Data System (ADS)

Wiggins, H. V.; Warnick, W. K.; Hempel, L. C.; Henk, J.; Sorensen, M.; Tweedie, C. E.; Gaylord, A.; Behr, S.

2006-12-01

As the creation and use of geospatial data in research, management, logistics, and education applications has proliferated, there is now a tremendous potential for advancing the IPY initiative through a variety of cyberinfrastructure applications, including Spatial Data Infrastructure (SDI) and related technologies. SDIs provide a necessary and common framework of standards, securities, policies, procedures, and technology to support the effective acquisition, coordination, dissemination and use of geospatial data by multiple and distributed stakeholder and user groups. Despite the numerous research activities in the Arctic, there is no established SDI and, because of this lack of a coordinated infrastructure, there is inefficiency, duplication of effort, and reduced data quality and search ability of arctic geospatial data. The urgency for establishing this framework is significant considering the myriad of data that is likely to be collected in celebration of the International Polar Year (IPY) in 2007-2008 and the current international momentum for an improved and integrated circumarctic terrestrial-marine-atmospheric environmental observatories network. The key objective of this project is to lay the foundation for full implementation of an Arctic Spatial Data Infrastructure (ASDI) through two related activities: (1) an assessment - via interviews, questionnaires, a workshop, and other means - of community needs, readiness, and resources, and (2) the development of a prototype web mapping portal to demonstrate the purpose and function on an arctic geospatial one-stop portal technology and to solicit community input on design and function. The results of this project will be compiled into a comprehensive report guiding the research community and funding agencies in the design and implementation of an ASDI to contribute to a robust IPY data cyberinfrastructure.

A half century perspective on the International Geophysical Year (IGY) - A Template for the International Polar Year 2007 (IPY 2007)?

NASA Astrophysics Data System (ADS)

Behrendt, J. C.

2003-12-01

In 1956 I sailed for Antarctica to spend 18 months as a graduate student participating in geophysical-glaciological investigations, as part of the 18-month IGY. This led to a career in geophysics, which has taken me to all of the continents and oceans. As we approach the IPY 2007, the changes in technology and our understanding of the earth over the past half century are breathtaking to contemplate. Although 70 countries participated in IGY, the disciplines were restricted to geophysics. Originally the Third Polar Year, the name was changed to IGY in 1952, at the suggestion of Sydney Chapman. The geographical area comprised the entire earth. The highest priority was given to "problems requiring concurrent synoptic observations at many points involving cooperative observations by many stations." One category was reserved for research on topics such as ocean levels, weather patterns, and the distribution of glacier ice "to establish basic information for subsequent comparison at later epochs." IPY 2007 seems such an epoch. A major international efforts was concentrated in Antarctica, although only 12 counties participated. Glaciology, seismology, auroral studies, ionospheric soundings, magnetic field measurements, and other solar-terrestrial, and meteorological observations comprised the scientific station activities. The only major field activities away from the stations were the oversnow geophysical-glaciological traverses, which made seismic measurements of ice thickness and other ice properties; gravity and magnetic anomaly profiles; and determination of snow accumulation and mean annual temperature. The most intensive of the oversnow traverse programs were those of the U.S. and USSR. Geology and topographic mapping were excluded from the Antarctica because of potential complications due to territorial claims and the possibility of mineral resource discoveries. Despite this, significant geologic findings, such as the discovery of the Dufek intrusion, were made by glaciologists and geophysicists with geologic training. Biology was not an IGY discipline, but even in this case, noted ornithologist, Carl Ekland (at Wilkes Station), carried out significant investigations of skuas. Physical oceanographic investigations resulted in geologic and biological sampling of the sea floor as well. A very few of the significant accomplishments of the IGY include the discovery of the Van Allen belts (the symbol of the IGY was a satellite circling the earth); the observation (at Mauna Loa) and recognition of the rapid global increase in carbon dioxide; the first major models of Arctic sea ice formation, decay, and drift; and the mapping of the midocean ridge system. In Antarctica, a first approximation of the mass of the ice sheet including the order of magnitude thicker ice than previously known (4 km) was a highlight. A baseline of mean annual temperatures measured (to about 0.1 degree accuracy) at about 40 km intervals along thousands of km of oversnow traverses was defined. Three World Data Centers were established; scientific results and data were deposited and made freely available to all. The peaceful international cooperation in Antarctica led directly to the signing of the Antarctic Treaty in 1959, with the first disarmament and freedom of inspection and scientific investigations clauses in history, covering a large area of the earth. I anticipate even greater international scientific cooperation from the IPY 2007. A new generation of polar scientists was developed as a result of IGY; a few of us are still active in Antarctic research. A similar result will provide continuity for the next 50 years.

Enhanced optical security by using information carrier digital screening

NASA Astrophysics Data System (ADS)

Koltai, Ferenc; Adam, Bence

2004-06-01

Jura has developed different security features based on Information Carrier Digital Screening. Substance of such features is that a non-visible secondary image is encoded in a visible primary image. The encoded image will be visible only by using a decoding device. One of such developments is JURA's Invisible Personal Information (IPI) is widely used in high security documents, where personal data of the document holder are encoded in the screen of the document holder's photography and they can be decoded by using an optical decoding device. In order to make document verification fully automated, enhance security and eliminate human factors, digital version of IPI, the D-IPI was developed. A special 2D-barcode structure was designed, which contains sufficient quantity of encoded digital information and can be embedded into the photo. Other part of Digital-IPI is the reading software, that is able to retrieve the encoded information with high reliability. The reading software developed with a specific 2D structure is providing the possibility of a forensic analysis. Such analysis will discover all kind of manipulations -- globally, if the photography was simply changed and selectively, if only part of the photography was manipulated. Digital IPI is a good example how benefits of digital technology can be exploited by using optical security and how technology for optical security can be converted into digital technology. The D-IPI process is compatible with all current personalization printers and materials (polycarbonate, PVC, security papers, Teslin-foils, etc.) and can provide any document with enhanced security and tamper-resistance.

International Youth Conference on the Poles

NASA Astrophysics Data System (ADS)

Church, A. K.; Kuhn, T. S.; Baeseman, J.; Garmulewicz, A.; Raymond, M.; Salmon, R.

2006-12-01

The International Polar Year (IPY) is an international effort, involving more than 50 countries, to focus research in both the sciences and social sciences on the world's Polar Regions. In order to secure youth involvement in the IPY, the Youth Steering Committee (YSC) has been formed, aiming specifically to network young polar researchers from all backgrounds enabling collaboration and to involve this group in outreach focused towards other young people. A conference targeted directly at an audience of early career researchers and international youth will be central to fulfilling these aims. The YSC has therefore developed the concept of the International Youth Conference on the Poles (IYCP). Proposed for 2008, this conference will bring together youth from a diverse set of backgrounds and nationalities to discuss the issues affecting the Polar Regions, their effects on a global scale and ways of addressing these issues. The conference will also serve to highlight ongoing IPY research, especially research being undertaken by young researchers, and provide a perennial framework for youth involvement in polar research and policies. The IYCP will run for three days in May 2008, attracting an international youth audience, as well as representatives from polar organizations, teachers, politicians, policy makers, the general public and media. The IYCP will be divided into three sections. Youth Roundtable Discussions will bring youth together to discuss issues affecting the Polar Regions and potential solutions to these. A Young Researchers Conference will provide the opportunity for young researchers working in the Polar Regions to present their work to an interdisciplinary audience. The Polar Fair will provide an interactive environment for youth to learn about the Polar Regions. The IYCP will be of great importance to the IPY because it will serve as the principle venue during the Polar Year where youth from many different disciplines, backgrounds and countries will be able to gather and interact. It will inspire many young people to become more actively involved in polar research and issues, while reinforcing for those currently undertaking these endeavours the importance of their contribution.

Changing dietary patterns and body mass index over time in Canadian Inuit communities.

PubMed

Sheikh, Nelofar; Egeland, Grace M; Johnson-Down, Louise; Kuhnlein, Harriet V

2011-01-01

The International Polar Year (IPY) Inuit Health Survey provided an opportunity to compare dietary and body mass index (BMI) data with data collected a decade earlier for the same communities. A dietary survey included 1,929 randomly selected participants aged 15 years or older, selected from 18 Inuit communities in 1998-1999. The IPY survey included 2,595 randomly selected participants aged 18 years or older, selected from 36 Inuit communities in 2007-2008. Data from the same 18 communities included in both surveys were compared for adults 20 years and older. Twenty-four-hour dietary recall data were analysed to assess the percentage of energy from traditional and market foods by sex and age groups. Body mass index (BMI) was assessed to establish the prevalence of obesity by sex and age groups in both surveys. There was a significant decrease (p≤0.05) in energy contribution from traditional food and a significant increase in market food consumption over time. Sugar-sweetened beverages, chips and pasta all increased as percentages of energy. BMI increased overall for women and for each age stratum evaluated (p<0.05). The nutrition transition continues in the Canadian Arctic with a concurrent increase in BMI.

International Polar Year Information Resources: Science Librarians Behind the Scenes and in the Field

NASA Astrophysics Data System (ADS)

Hicks, G. J.; Sommer, S.

2006-12-01

As the International Polar Year approaches, research institutes, scientists, and students are preparing for the challenges of field research and the resulting reports and papers. In support of these researchers, libraries and information centers are developing programs and special projects to provide the information and repositories vital to dissemination of the resulting data and reports. From the National Snow and Ice Data Center's DAHLI project to Scott Polar Research Institute's Discovering the Poles, polar science librarians around the world are gearing up to provide service and information to researchers at home and in the field. Not only will these information specialists and librarians provide resources or answer questions for the scientist in the office, they will also provide much of those same services to the researcher in the field. IPY resources are a special case of the on-demand services science librarians typically provide. They help scientists formulate search strategies and take advantage of new developments in scientific databases at their home institutes. They provide many of the same services to researchers in the field. Whether sitting on an ice breaker in the Southern Ocean or in a tent on a glacier in Spitsbergen, field scientists can email or IM a question to a librarian for digital copies of papers, answers to reference questions, or information from a source in the office. IPY data and publications will be distributed among many existing and a few new clearinghouses and article databases. Science librarians will ensure that their researchers can locate and use these resources, providing a vital service and many important resources for this global effort to understand the current status of climate change and its effect around the globe.

Implementation of an ASP model offsite backup archive for clinical images utilizing Internet 2

NASA Astrophysics Data System (ADS)

Liu, Brent J.; Chao, Sander S.; Documet, Jorge; Lee, Jasper; Lee, Michael; Topic, Ian; Williams, Lanita

2005-04-01

With the development of PACS technology and an increasing demand by medical facilities to become filmless, there is a need for a fast and efficient method of providing data backup for disaster recovery and downtime scenarios. At the Image Processing Informatics Lab (IPI), an ASP Backup Archive was developed using a fault-tolerant server with a T1 connection to serve the PACS at the St. John's Health Center (SJHC) Santa Monica, California. The ASP archive server has been in clinical operation for more than 18 months, and its performance was presented at this SPIE Conference last year. This paper extends the ASP Backup Archive to serve the PACS at the USC Healthcare Consultation Center II (HCC2) utilizing an Internet2 connection. HCC2 is a new outpatient facility that recently opened in April 2004. The Internet2 connectivity between USC's HCC2 and IPI has been established for over one year. There are two novelties of the current ASP model: 1) Use of Internet2 for daily clinical operation, and 2) Modifying the existing backup archive to handle two sites in the ASP model. This paper presents the evaluation of the ASP Backup Archive based on the following two criteria: 1) Reliability and performance of the Internet2 connection between HCC2 and IPI using DICOM image transfer in a clinical environment, and 2) Ability of the ASP Fault-Tolerant backup archive to support two separate clinical PACS sites simultaneously. The performances of using T1 and Internet2 at the two different sites are also compared.

Training the New Generation of Polar Researchers

NASA Astrophysics Data System (ADS)

Drobot, S.; Weiler, C. S.

2008-12-01

The polar regions are changing rapidly, and many of the pressing problems faced in the future will require a new generation of polar researchers to be disciplinary experts and work across traditional disciplinary boundaries to conduct socially relevant, transformative research, and translate it to more effective action. To learn about the past and better address these new challenges, a select international group of 35 students and early career researchers who are conducting research during the 2007-2009 International Polar Year were brought together May 4-11, 2008, at the La Foret Conference Center for the New Generation Polar Research (NGPR) Symposium. The participants were drawn from professional backgrounds spanning the spectrum of social, natural, and physical sciences and represented the research programs of 7 countries. In addition to the participants, 12 mentors, some of whom participated in the IGY, shared insights, stories, and expertise. This diverse and ambitious group spent an intensive week learning about many important aspects of IPY history and research, along with communication, outreach, interdisciplinary research and career development. Each of the participants presented a 7-minute overview of his or her IPY research and provided details and discussion in evening poster sessions. Polar history provided an informative and unifying context for discussions of the past, present, and future that lasted throughout the week. Mentors and guest speakers shared insights and advice on media interactions, and many participants were subsequently interviewed for an upcoming radio story to be aired on National Public Radio. Several presentations on outreach were followed by a hands-on session for a group 1st grade students who were visiting the La Foret Conference Center. The Symposium also featured several break-out sessions, where small groups of participants and mentors discussed challenges related to interdisciplinary research, science advocacy, and maintaining a work/life balance. In addition, each participant recorded a two-minute video overview of their research interests to be archived at the American Institute of Physics as a sort of "time capsule" to be shared with students, researchers, historians of science and the general public during the next IPY. This presentation will highlight this exciting week.

Improved survival and complete response rates in patients with advanced melanoma treated with concurrent ipilimumab and radiotherapy versus ipilimumab alone.

PubMed

Koller, Kristian M; Mackley, Heath B; Liu, Jason; Wagner, Henry; Talamo, Giampaolo; Schell, Todd D; Pameijer, Colette; Neves, Rogerio I; Anderson, Bryan; Kokolus, Kathleen M; Mallon, Carol A; Drabick, Joseph J

2017-01-02

There is a growing body of evidence supporting the synergistic roles of radiotherapy and immunotherapy in the treatment of malignancy. Published case studies of the abscopal effect have been reported with the use of ipilimumab and radiotherapy in metastatic melanoma, but evidence supporting the routine use of this combination of therapy is limited. We conducted a retrospective analysis to evaluate patients treated with ipilimumab for advanced melanoma at a single institution from May 2011 to June 2015. Patients were grouped into those who had received concurrent radiotherapy while on ipilimumab (Ipi-RT), and those who did not. We then evaluated the treatment response following completion of ipilimumab. A total of 101 patients received ipilimumab in the prespecified time frame. 70 received Ipi-RT and 31 received ipilimumab without concurrent radiotherapy. Median overall survival (OS) was significantly increased in the concurrent Ipi-RT arm at 19 months vs. 10 months for ipilimumab alone (p = 0.01). Median progression free survival (PFS) was marginally increased in the Ipi-RT group compare with the ipilimumab alone group (5 months vs. 3 months, p = 0.20). Rates of complete response (CR) were significantly increased in the Ipi-RT group vs. ipilimumab alone (25.7% vs. 6.5%; p = 0.04), and rates of overall response (OR) in the groups were 37.1% vs. 19.4% (p = 0.11). No increase in toxicities was observed in the Ipi-RT group compare with ipilimumab alone. Prospective trials are needed to further clarify the role of radiotherapy with ipilimumab, but these encouraging preliminary observations suggest that this combination can induce more durable responses to immunotherapy.

Improved survival and complete response rates in patients with advanced melanoma treated with concurrent ipilimumab and radiotherapy versus ipilimumab alone

PubMed Central

Koller, Kristian M.; Mackley, Heath B.; Liu, Jason; Wagner, Henry; Talamo, Giampaolo; Schell, Todd D.; Pameijer, Colette; Neves, Rogerio I.; Anderson, Bryan; Kokolus, Kathleen M.; Mallon, Carol A.; Drabick, Joseph J.

2017-01-01

ABSTRACT There is a growing body of evidence supporting the synergistic roles of radiotherapy and immunotherapy in the treatment of malignancy. Published case studies of the abscopal effect have been reported with the use of ipilimumab and radiotherapy in metastatic melanoma, but evidence supporting the routine use of this combination of therapy is limited. We conducted a retrospective analysis to evaluate patients treated with ipilimumab for advanced melanoma at a single institution from May 2011 to June 2015. Patients were grouped into those who had received concurrent radiotherapy while on ipilimumab (Ipi-RT), and those who did not. We then evaluated the treatment response following completion of ipilimumab. A total of 101 patients received ipilimumab in the prespecified time frame. 70 received Ipi-RT and 31 received ipilimumab without concurrent radiotherapy. Median overall survival (OS) was significantly increased in the concurrent Ipi-RT arm at 19 months vs. 10 months for ipilimumab alone (p = 0.01). Median progression free survival (PFS) was marginally increased in the Ipi-RT group compare with the ipilimumab alone group (5 months vs. 3 months, p = 0.20). Rates of complete response (CR) were significantly increased in the Ipi-RT group vs. ipilimumab alone (25.7% vs. 6.5%; p = 0.04), and rates of overall response (OR) in the groups were 37.1% vs. 19.4% (p = 0.11). No increase in toxicities was observed in the Ipi-RT group compare with ipilimumab alone. Prospective trials are needed to further clarify the role of radiotherapy with ipilimumab, but these encouraging preliminary observations suggest that this combination can induce more durable responses to immunotherapy. PMID:27905824

A fast BK-type KCa current acts as a postsynaptic modulator of temporal selectivity for communication signals.

PubMed

Kohashi, Tsunehiko; Carlson, Bruce A

2014-01-01

Temporal patterns of spiking often convey behaviorally relevant information. Various synaptic mechanisms and intrinsic membrane properties can influence neuronal selectivity to temporal patterns of input. However, little is known about how synaptic mechanisms and intrinsic properties together determine the temporal selectivity of neuronal output. We tackled this question by recording from midbrain electrosensory neurons in mormyrid fish, in which the processing of temporal intervals between communication signals can be studied in a reduced in vitro preparation. Mormyrids communicate by varying interpulse intervals (IPIs) between electric pulses. Within the midbrain posterior exterolateral nucleus (ELp), the temporal patterns of afferent spike trains are filtered to establish single-neuron IPI tuning. We performed whole-cell recording from ELp neurons in a whole-brain preparation and examined the relationship between intrinsic excitability and IPI tuning. We found that spike frequency adaptation of ELp neurons was highly variable. Postsynaptic potentials (PSPs) of strongly adapting (phasic) neurons were more sharply tuned to IPIs than weakly adapting (tonic) neurons. Further, the synaptic filtering of IPIs by tonic neurons was more faithfully converted into variation in spiking output, particularly at short IPIs. Pharmacological manipulation under current- and voltage-clamp revealed that tonic firing is mediated by a fast, large-conductance Ca(2+)-activated K(+) (KCa) current (BK) that speeds up action potential repolarization. These results suggest that BK currents can shape the temporal filtering of sensory inputs by modifying both synaptic responses and PSP-to-spike conversion. Slow SK-type KCa currents have previously been implicated in temporal processing. Thus, both fast and slow KCa currents can fine-tune temporal selectivity.

Echolocating Big Brown Bats, Eptesicus fuscus, Modulate Pulse Intervals to Overcome Range Ambiguity in Cluttered Surroundings

PubMed Central

Wheeler, Alyssa R.; Fulton, Kara A.; Gaudette, Jason E.; Simmons, Ryan A.; Matsuo, Ikuo; Simmons, James A.

2016-01-01

Big brown bats (Eptesicus fuscus) emit trains of brief, wideband frequency-modulated (FM) echolocation sounds and use echoes of these sounds to orient, find insects, and guide flight through vegetation. They are observed to emit sounds that alternate between short and long inter-pulse intervals (IPIs), forming sonar sound groups. The occurrence of these strobe groups has been linked to flight in cluttered acoustic environments, but how exactly bats use sonar sound groups to orient and navigate is still a mystery. Here, the production of sound groups during clutter navigation was examined. Controlled flight experiments were conducted where the proximity of the nearest obstacles was systematically decreased while the extended scene was kept constant. Four bats flew along a corridor of varying widths (100, 70, and 40 cm) bounded by rows of vertically hanging plastic chains while in-flight echolocation calls were recorded. Bats shortened their IPIs for more rapid spatial sampling and also grouped their sounds more tightly when flying in narrower corridors. Bats emitted echolocation calls with progressively shorter IPIs over the course of a flight, and began their flights by emitting shorter starting IPI calls when clutter was denser. The percentage of sound groups containing 3 or more calls increased with increasing clutter proximity. Moreover, IPI sequences having internal structure become more pronounced when corridor width narrows. A novel metric for analyzing the temporal organization of sound sequences was developed, and the results indicate that the time interval between echolocation calls depends heavily on the preceding time interval. The occurrence of specific IPI patterns were dependent upon clutter, which suggests that sonar sound grouping may be an adaptive strategy for coping with pulse-echo ambiguity in cluttered surroundings. PMID:27445723

Strategies to reduce inappropriate laboratory blood test orders in intensive care are effective and safe: a before-and-after quality improvement study.

PubMed

Dhanani, J A; Barnett, A G; Lipman, J; Reade, M C

2018-05-01

Unnecessary pathology tests performed in intensive care units (ICU) might lead to increased costs of care and potential patient harm due to unnecessary phlebotomy. We hypothesised that a multimodal intervention program could result in a safe and effective reduction in the pathology tests ordered in our ICU. We conducted a single-centre pre- and post-study using multimodal interventions to address commonly ordered routine tests. The study was performed during the same six month period (August to February) over three years: 2012 to 2013 (pre-intervention), 2013 to 2014 (intervention) and 2014 to 2015 (post-intervention). Interventions consisted of staff education, designing new pathology forms, consultant-led pathology test ordering and intensive monitoring for a six-month period. The results of the study showed that there was a net savings of over A$213,000 in the intervention period and A$175,000 in the post-intervention period compared to the pre-intervention period. There was a 28% reduction in the tests performed in the intervention period (P <0.0001 compared to pre-intervention period) and 26% in the post-intervention period (P <0.0001 compared to pre-intervention period). There were no ICU or hospital mortality differences between the groups. There were no significant haemoglobin differences between the groups. A multimodal intervention safely reduced pathology test ordering in the ICU, resulting in substantial cost savings.

Intestinal parasitic infections among children under five years of age presenting with diarrhoeal diseases to two public health facilities in Hawassa, South Ethiopia.

PubMed

Mulatu, Getamesay; Zeynudin, Ahmed; Zemene, Endalew; Debalke, Serkadis; Beyene, Getenet

2015-11-04

Diarrhoea is the leading cause of morbidity and mortality in children under 5 years of age in developing countries, including Ethiopia. It is caused by a wide range of pathogens, including parasites, bacteria and viruses. The aim of this study was to determine the prevalence of infection with intestinal parasites (IPs) (and types) among children under 5 years of age with diarrhoeal diseases. A cross-sectional study was conducted at Adare Hospital and Millennium Health Centre, both located in Hawassa, South Ethiopia, from June 6 to October 28, 2011. Children under 5 years of age with diarrhoea who visited these health facilities during the study period were included in the study. Data relating to demography and risk factors associated with intestinal parasitic infections (IPIs) were gathered using a structured questionnaire. Single, fresh stool specimens were examined for IPs using the direct wet mount examination, followed by Ziehl-Neelsen staining of formol-ether concentrated samples, as per standard procedures. Data were analysed using SPSS Statistics 20 software. A total of 158 children (51.3 % male and 48.7 % female) participated in the study. Overall, the prevalence of IPs was 26.6 % (42/158). Two species of IPs were detected in six children (3.8 %). Entamoeba histolytica/dispar/moshkovskii was the predominant parasite identified (11.4 %), followed by Giardia duodenalis (7.0 %). The multivariable analysis revealed that the age group ≥24 months was significantly associated (AOR = 0.221, 95 %CI: 0.085-0.576) with prevalence of IPIs. This study found that intestinal parasites are common among children with diarrheal diseases. The most frequently detected species was E. histolytica/dispar/moshkovskii. Health information about how to prevent diarrheal diseases in general and IPIs in particular should be provided to parents of young children.

[Integrative parent-infant psychotherapy for early regulatory and relationship disorders].

PubMed

Papousek, Mechthild; de Chuquisengo, Ruth Wollwerth

2006-01-01

The author introduces both the concept and practice of Integrative Parent-Infant Psychotherapy (IPI-P), a treatment specifically designed for the most frequent developmental problems and psychological needs of infants and their parents. Based on growing knowledge from interdisciplinary infancy research, both basic and clinical, IPI-P has been developed and practised in the "Munich Interdisciplinary Research and Intervention Program" for early regulatory and relationship disorders since the early nineties. Preverbal parent-infant communication represents both the port of entry into the system and the main focus of diagnostics, developmental counselling, interaction guidance, or psychodynamic psychotherapy of distorted communication and distressed/disordered relationships. The method of videomicroanalysis during video-feedback with the parent has proven particularly efficient--while observing, reliving and working through brief episodes of recorded parent-infant interaction. The author illustrates the diagnostic and therapeutic procedures with excerpts from psychotherapy of a toddler with an age-specific regulatory disorder in the context of severely distressed primary relationships.

Individually Prescribed Instruction: Background Information and Research.

ERIC Educational Resources Information Center

DeRenzis, Joseph J.

The effects of individually prescribed instruction (IPI) in reading as compared to the traditional mode of instruction are examined. The IPI model includes four components: analysis of subject matter content, diagnosis of student preinstructional behavior, sequencing of materials to facilitate learning, and evaluation strategies. Elementary…

Phase II Evaluation of IPI-926, an Oral Hedgehog Inhibitor, in Patients with Myelofibrosis

PubMed Central

Sasaki, Koji; Gotlib, Jason R.; Mesa, Ruben A.; Newberry, Kate J.; Ravandi, Farhad; Cortes, Jorge E.; Kelly, Patrick; Kutok, Jeffery L.; Kantarjian, Hagop M.; Verstovsek, Srdan

2016-01-01

The clinical safety and efficacy of IPI-926 was evaluated in 14 patients with myelofibrosis in a phase II study. Patients received 160-mg IPI-926 orally in continuous 28-day cycles. The median treatment duration was 5.1 months, and all patients had discontinued treatment by 7.5 months. Nine patients discontinued due to lack of response as determined by the treating physician, two after developing acute leukemia and one due to disease progression/loss of response. Twelve patients had slight reductions in spleen size (less than 50% from baseline), but symptoms did not improve consistently. One patient achieved transfusion independence lasting 5 months. Reductions in GLI1 mRNA and protein levels, JAK2V617F allele burden, degree of fibrosis, or cytokine levels were observed in some patients, but were not significant when evaluated for the cohort. Low-grade gastrointestinal/liver abnormalities were the most common toxicities. The results did not support continued evaluation of IPI-926 as a monotherapy in myelofibrosis. PMID:25641433

Increased CRF signaling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal

PubMed Central

Zhao-Shea, Rubing; DeGroot, Steven R.; Liu, Liwang; Vallaster, Markus; Pang, Xueyan; Su, Qin; Gao, Guangping; Rando, Oliver J.; Martin, Gilles E.; George, Olivier; Gardner, Paul D.; Tapper, Andrew R.

2015-01-01

Increased anxiety is a predominant withdrawal symptom in abstinent smokers, yet the neuroanatomical and molecular bases underlying it are unclear. Here, we show that withdrawal-induced anxiety increases activity of neurons in the interpeduncular intermediate (IPI), a subregion of the interpeduncular nucleus (IPN). IPI activation during nicotine withdrawal was mediated by increased corticotropin releasing factor (CRF) receptor-1 expression and signaling, which modulated glutamatergic input from the medial habenula (MHb). Pharmacological blockade of IPN CRF1 receptors or optogenetic silencing of MHb input reduced IPI activation and alleviated withdrawal-induced anxiety; whereas IPN CRF infusion in mice increased anxiety. We identified a meso-interpeduncular circuit, consisting of ventral tegmental area (VTA) dopaminergic neurons projecting to the IPN, as a potential source of CRF. Knock-down of CRF synthesis in the VTA prevented IPI activation and anxiety during nicotine withdrawal. These data indicate that increased CRF receptor signaling within a VTA-IPN-MHb circuit triggers anxiety during nicotine withdrawal. PMID:25898242

Impact of Increasing Inter-pregnancy Interval on Maternal and Infant Health

PubMed Central

Wendt, Amanda; Gibbs, Cassandra M.; Peters, Stacey; Hogue, Carol J.

2015-01-01

Short inter-pregnancy intervals (IPIs) have been associated with adverse maternal and infant health outcomes in the literature. However, many studies in this area have been lacking in quality and appropriate control for confounders known to be associated with both short IPIs and poor outcomes. The objective of this systematic review was to assess this relationship using more rigorous criteria, based on GRADE (Grading of Recommendations Assessment, Development and Evaluation) methodology. We found too few higher-quality studies of the impact of IPIs (measured as the time between the birth of a previous child and conception of the next child) on maternal health to reach conclusions about maternal nutrition, morbidity or mortality. However, the evidence for infant effects justified meta-analyses. We found significant impacts of short IPIs for extreme preterm birth [<6 m adjusted odds ratio (aOR): 1.58 [95% confidence interval (CI) 1.40, 1.78], 6–11 m aOR: 1.23 [1.03, 1.46

Factors associated with short interpregnancy interval in women who plan postpartum LARC: a retrospective study.

PubMed

Harney, Clare; Dude, Annie; Haider, Sadia

2017-03-01

Pregnancies conceived after a short interpregnancy interval (IPI), within 18 months of delivery, and unintended pregnancies are both associated with health risks. We studied risk factors for conception after a short IPI among postpartum women who plan long-acting reversible contraception (LARC). A retrospective review of a cohort of women who delivered at University of Illinois Hospital from 2005 to 2010 and were discharged with a plan for interval LARC was performed. Outcomes were (1) attendance at a postpartum visit (PPV), (2) LARC placement (3) and conception after a short IPI. We compared variables using chi-squared test, Student's t tests and multivariable logistic regression. Of 3548 women, 62.0% attended a PPV, 36.5% received LARC and 11.4% conceived after a short IPI. After logistic regression, women who were multiparous [odds ratio (OR) 0.77, 95% confidence interval (CI) 0.65-0.91] or chose a temporary contraceptive "bridge" to LARC (OR 0.74, 95% CI 0.58-0.94) were less likely to attend their PPV. Women who missed their PPV (OR 0.06, 95% CI 0.05-0.08) or chose a bridge (OR 0.66, 95% CI 0.50-0.88) were less likely to receive LARC. Finally, women who did not receive LARC (OR 4.8, 95% CI 3.50-6.70), were multiparous (OR 1.69, 95% CI 1.32-2.15) or teenaged (OR 2.12, 95% CI 1.61-2.79) were more likely to conceive after a short IPI. Women who receive postpartum LARC are less likely to become pregnant after a short IPI. Missing the PPV, multiparity and plan for a contraceptive bridge may all contribute to a patient not receiving planned LARC. Efforts to decrease unintended pregnancy after a short IPI should focus on decreasing barriers to planned postpartum LARC. Provision of temporary bridge contraception until interval LARC may not mitigate the significant barriers associated with interval postpartum placement protocols. Copyright © 2017 Elsevier Inc. All rights reserved.

Independent Prognostic Value of Serum Markers in Diffuse Large B-Cell Lymphoma in the Era of the NCCN-IPI.

PubMed

Melchardt, Thomas; Troppan, Katharina; Weiss, Lukas; Hufnagl, Clemens; Neureiter, Daniel; Tränkenschuh, Wolfgang; Schlick, Konstantin; Huemer, Florian; Deutsch, Alexander; Neumeister, Peter; Greil, Richard; Pichler, Martin; Egle, Alexander

2015-12-01

Several serum parameters have been evaluated for adding prognostic value to clinical scoring systems in diffuse large B-cell lymphoma (DLBCL), but none of the reports used multivariate testing of more than one parameter at a time. The goal of this study was to validate widely available serum parameters for their independent prognostic impact in the era of the National Comprehensive Cancer Network-International Prognostic Index (NCCN-IPI) score to determine which were the most useful. This retrospective bicenter analysis includes 515 unselected patients with DLBCL who were treated with rituximab and anthracycline-based chemoimmunotherapy between 2004 and January 2014. Anemia, high C-reactive protein, and high bilirubin levels had an independent prognostic value for survival in multivariate analyses in addition to the NCCN-IPI, whereas neutrophil-to-lymphocyte ratio, high gamma-glutamyl transferase levels, and platelets-to-lymphocyte ratio did not. In our cohort, we describe the most promising markers to improve the NCCN-IPI. Anemia and high C-reactive protein levels retain their power in multivariate testing even in the era of the NCCN-IPI. The negative role of high bilirubin levels may be associated as a marker of liver function. Further studies are warranted to incorporate these markers into prognostic models and define their role opposite novel molecular markers. Copyright © 2015 by the National Comprehensive Cancer Network.

Automatic Realistic Real Time Stimulation/Recording in Weakly Electric Fish: Long Time Behavior Characterization in Freely Swimming Fish and Stimuli Discrimination

PubMed Central

Forlim, Caroline G.; Pinto, Reynaldo D.

2014-01-01

Weakly electric fish are unique model systems in neuroethology, that allow experimentalists to non-invasively, access, central nervous system generated spatio-temporal electric patterns of pulses with roles in at least 2 complex and incompletely understood abilities: electrocommunication and electrolocation. Pulse-type electric fish alter their inter pulse intervals (IPIs) according to different behavioral contexts as aggression, hiding and mating. Nevertheless, only a few behavioral studies comparing the influence of different stimuli IPIs in the fish electric response have been conducted. We developed an apparatus that allows real time automatic realistic stimulation and simultaneous recording of electric pulses in freely moving Gymnotus carapo for several days. We detected and recorded pulse timestamps independently of the fish’s position for days. A stimulus fish was mimicked by a dipole electrode that reproduced the voltage time series of real conspecific according to previously recorded timestamp sequences. We characterized fish behavior and the eletrocommunication in 2 conditions: stimulated by IPIs pre-recorded from other fish and random IPI ones. All stimuli pulses had the exact Gymontus carapo waveform. All fish presented a surprisingly long transient exploratory behavior (more than 8 h) when exposed to a new environment in the absence of electrical stimuli. Further, we also show that fish are able to discriminate between real and random stimuli distributions by changing several characteristics of their IPI distribution. PMID:24400122

Identification of Silver and Palladium in Irradiated TRISO Coated Particles of the AGR-1 Experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

van Rooyen, Y. J.; Lillo, T. M.; Wu, Y. Q.

2014-03-01

Evidence of the release of certain metallic fission product through intact tristructural isotropic (TRISO) particles has been seen for decades around the world, as well as in the recent AGR-1 experiment at Idaho National Laboratory (INL). However, understanding the basic mechanism of transport is still lacking. This understanding is important because the TRISO coating is part of the high temperature gas reactor functional containment and critical for the safety strategy for licensing purposes. Our approach to identify fission products in irradiated AGR-1 TRISO fuel using scanning transmission electron microscopy (STEM), Electron Energy Loss Spectroscopy (EELS) and Energy Filtered TEM (EFTEM),more » has led to first-of-a-kind data at the nano-scale indicating the presence of silver at triple points and grain boundaries of the SiC layer in the TRISO particle. Cadmium was also found in the triple junctions. In this initial study, the silver was only identified in SiC grain boundaries and triple points on the edge of the SiC-IPyC interface up to a depth of approximately 0.5 um. Palladium was identified as the main constituent of micron-sized precipitates present at the SiC grain boundaries. Additionally spherical nano-sized palladium rich precipitates were found inside the SiC grains. These nano-sized Pd precipitates were distributed up to a depth of 5 um away from the SiC-IPyC interlayer. No silver was found in the center of the micron-sized fission product precipitates using these techniques, although silver was found on the outer edge of one of the Pd-U-Si containing precipitates which was facing the IPyC layer. Only Pd-U containing precipitates were identified in the IPyC layer and no silver was identified in the IPyC layer. The identification of silver alongside the grain boundaries and the findings of Pd alongside grain boundaries as well as inside the grains, provide significant knowledge for understanding silver and palladium transport in TIRSO fuel, which has been the topic of international research for the past forty years. Additionally the usefulness of the advanced electron microscopic techniques for TRISO coated particle research is demonstrated in this paper.« less

Assessment of interferences during field measurements of OH using a laser-induced fluorescence instrument equipped with a scavenger injector

NASA Astrophysics Data System (ADS)

Heard, Dwayne; Woodward-Massey, Robert; Slater, Eloise; Ye, Chunxiang; Seakins, Paul; Whalley, Lisa

2017-04-01

The hydroxyl radical is the most important atmospheric oxidant controlling the lifetimes of the majority of trace gases, including the greenhouse gas methane, and initiates the formation of harmful pollutants such as ozone and secondary organic aerosol. It has a very short lifetime of typically a second or less and hence its concentration is controlled by local in situ chemistry rather than transport, and hence is an ideal target for models containing detailed oxidation mechanisms. However, its accurate measurement in the atmosphere is extremely challenging, and despite having been measured in the troposphere for 30 years there remain uncertainties surrounding potential interferences in its measurement, which have been reported recently in some environments for some instruments. A new inlet pre-injector (IPI) has been developed for the Leeds FAGE (fluorescence assay by gas expansion) instrument which allows removal of ambient OH by addition of a chemical scavenger prior to the fluorescence detection cell. In this manner the background is determined and is subtracted from the OH signal determined during field measurements leading to a measurement of OH referred to as OH-CHEM. In the more traditional method the background is determined by tuning the wavelength of the laser away from the OH transition leading to a measurement of OH referred to as OH-WAVE. A detailed laboratory characterization will be presented of the IPI using OH removal using either propane or perfluoropropene (C3F6) as scavengers, with the presence of the IPI reducing the instrument OH sensitivity by 30%. There was no removal of OH within the fluorescence cell itself, and the IPI did not reduce the sensitivity of the instrument towards HO2. Results will be presented during deployment of the Leeds FAGE instrument equipped with the new IPI at a coastal location in Norfolk, England in the summer of 2015, and also in central Beijing, China in the winter of 2016. For both sites, which span a very wide range of NOx and VOC concentrations, OH-CHEM and OH-WAVE in general agreed well, within measurement uncertainties, demonstrating that at least for these locations there was no significant observed OH interference. Some results of further laboratory tests to investigate the potential presence of OH interferences formed during the ozonolysis of alkenes will also be presented.

Outcomes of diffuse large B-cell lymphoma patients relapsing after autologous stem cell transplantation: an analysis of patients included in the CORAL study.

PubMed

Van Den Neste, E; Schmitz, N; Mounier, N; Gill, D; Linch, D; Trneny, M; Bouadballah, R; Radford, J; Bargetzi, M; Ribrag, V; Dührsen, U; Ma, D; Briere, J; Thieblemont, C; Bachy, E; Moskowitz, C H; Glass, B; Gisselbrecht, C

2017-02-01

In the CORAL study, 255 chemosensitive relapses with diffuse large B-cell lymphoma (DLBCL) were consolidated with autologous stem cell transplantation (ASCT), and 75 of them relapsed thereafter. The median time between ASCT and progression was 7.1 months. The median age was 56.1 years; tertiary International Prognosis Index (tIPI) observed at relapse was 0-2 in 71.6% of the patients and >2 in 28.4%. The overall response rate to third-line chemotherapy was 44%. The median overall survival (OS) was 10.0 months (median follow-up: 32.8 months). Thirteen patients received an allogeneic SCT, and three a second ASCT. The median OS was shorter among patients who relapsed <6 months (5.7 months) compared with those relapsing ⩾12 months after ASCT (12.6 months, P=0.0221). The median OS in patients achieving CR, PR or no response after the third-line regimen was 37.7 (P<0.0001), 10.0 (P=0.03) and 6.3 months, respectively. The median OS varied according to tIPI: 0-2: 12.6 months and >2: 5.3 months (P=0.0007). In multivariate analysis, tIPI >2, achievement of response and remission lasting <6 months predicted the OS. This report identifies the prognostic factors for DLBCL relapsing after ASCT and thus helps to select patients for experimental therapy.

The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma: analysis of 126 patients from the International Peripheral T-Cell Lymphoma Project.

PubMed

Suzumiya, J; Ohshima, K; Tamura, K; Karube, K; Uike, N; Tobinai, K; Gascoyne, R D; Vose, J M; Armitage, J O; Weisenburger, D D

2009-04-01

The International Peripheral T-cell Lymphoma Project was organized to better understand the T-cell and natural killer (NK) cell lymphomas, and our task is to present the clinicopathologic correlations and therapeutic results for adult T-cell leukemia/lymphoma (ATL). Among 1153 patients with T-cell or NK cell lymphomas, 126 patients (9.6%) with ATL were represented in this project. All were categorized as aggressive ATL, i.e. acute or lymphoma type, and 87% fell into the lymphoma type. The median age was 62 years and the male to female ratio was 1.2 : 1. Significant prognostic factors for overall survival (OS) by univariate analysis were the presence of B symptoms (P = 0.018), platelet count <150 x 10(9)/l (P = 0.065), and the International Prognostic Index (IPI; P = 0.019). However, multivariate analysis indicated that only the IPI was an independent predictor of OS. Combination chemotherapy including anthracyclines was given as the initial therapy in 109 of the 116 patients (94%) who received treatment, and the overall and complete response rates were 70% and 34%, respectively. However, there was no survival benefit for those receiving an anthracycline-containing regimen. Patients with aggressive ATL have a poor clinical outcome and the IPI is a useful model for predicting outcome in ATL of the lymphoma type.

The prevalence of the sesamoid bones of the hand: a systematic review and meta-analysis.

PubMed

Yammine, Kaissar

2014-11-01

The literature contains various estimates of the prevalence and distribution of the sesamoid bones in the hands. The aims of this systematic review are to provide a better estimate of the frequency of hand sesamoids and its association with variables such as ancestry, gender, and side. Nineteen studies met the inclusion criteria. The pooled rates of the sensitive meta-analyses from large-sample studies in adults showed: (a) true overall rates of 99.9% for the metacarpophalangeal (MCP) joint of the thumb (MCP-I), 53% for the interphalangeal joint (IP-I), 43.4% for the MCP of the index (MCP-II), 1.47% for the MCP of the medius finger (MCP-III), 0.6% for the MCP of the ring finger (MCP-IV), and 67.7% for the MCP of the auricular finger (MCP-V); (b) true radiological rates of 99.9% for the radial thumb sesamoid, 99.6% for the ulnar thumb sesamoid, 47.8% for IP-I, 40% for MCP-II, 1.3% for MCP-III, 0.8% for MCP-VI, and 62.8% for MCP-V. Black, Middle Eastern, and European ancestries conferred significantly higher sesamoid frequencies at IP-I, MCP-II, and MCP-V, respectively. There was a significant association with female gender at MCP-II, MCP-IV, and MCP-V, with ORs of 1.53, 4, and 1.3, respectively, and a nonsignificant "female" trend for the other locations. There was no significant association with hand side. The pooled rates of hand sesamoids in children aged 10-17 years were 92.7, 42.2, 33.8, 0.5, 0.3, and 36.5% for MCP-I, IP-I, MCP-II, MCP-III, MCP-IV, and MCP-V, respectively. The findings of this evidence-based anatomical review provide quantitative evidence that the incidence of sesamoid bones in human hands depends on genetic rather than functional factors. © 2014 Wiley Periodicals, Inc.

Serum C-reactive protein (CRP) as a simple and independent prognostic factor in extranodal natural killer/T-cell lymphoma, nasal type.

PubMed

Li, Ya-Jun; Li, Zhi-Ming; Xia, Yi; Huang, Jia-Jia; Huang, Hui-Qiang; Xia, Zhong-Jun; Lin, Tong-Yu; Li, Su; Cai, Xiu-Yu; Wu-Xiao, Zhi-Jun; Jiang, Wen-Qi

2013-01-01

C-reactive protein (CRP) is a biomarker of the inflammatory response, and it shows significant prognostic value for several types of solid tumors. The prognostic significance of CRP for lymphoma has not been fully examined. We evaluated the prognostic role of baseline serum CRP levels in patients with extranodal natural killer (NK)/T-cell lymphoma (ENKTL). We retrospectively analyzed 185 patients with newly diagnosed ENKTL. The prognostic value of the serum CRP level was evaluated for the low-CRP group (CRP≤10 mg/L) versus the high-CRP group (CRP>10 mg/L). The prognostic value of the International Prognostic Index (IPI) and the Korean Prognostic Index (KPI) were evaluated and compared with the newly developed prognostic model. Patients in the high-CRP group tended to display increased adverse clinical characteristics, lower rates of complete remission (P<0.001), inferior progression-free survival (PFS, P = 0.001), and inferior overall survival (OS, P<0.001). Multivariate analysis demonstrated that elevated serum CRP levels, age >60 years, hypoalbuminemia, and elevated lactate dehydrogenase levels were independent adverse predictors of OS. Based on these four independent predictors, we constructed a new prognostic model that identified 4 groups with varying OS: group 1, no adverse factors; group 2, 1 factor; group 3, 2 factors; and group 4, 3 or 4 factors (P<0.001). The novel prognostic model was found to be superior to both the IPI in discriminating patients with different outcomes in the IPI low-risk group and the KPI in distinguishing between the low- and intermediate-low-risk groups, the intermediate-low- and high-intermediate-risk groups, and the high-intermediate- and high-risk groups. Our results suggest that pretreatment serum CRP levels represent an independent predictor of clinical outcome for patients with ENKTL. The prognostic value of the new prognostic model is superior to both IPI and KPI.

Serum C-Reactive Protein (CRP) as a Simple and Independent Prognostic Factor in Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type

PubMed Central

Xia, Yi; Huang, Jia-Jia; Huang, Hui-Qiang; Xia, Zhong-Jun; Lin, Tong-Yu; Li, Su; Cai, Xiu-Yu; Wu-Xiao, Zhi-Jun; Jiang, Wen-Qi

2013-01-01

Background C-reactive protein (CRP) is a biomarker of the inflammatory response, and it shows significant prognostic value for several types of solid tumors. The prognostic significance of CRP for lymphoma has not been fully examined. We evaluated the prognostic role of baseline serum CRP levels in patients with extranodal natural killer (NK)/T-cell lymphoma (ENKTL). Methods We retrospectively analyzed 185 patients with newly diagnosed ENKTL. The prognostic value of the serum CRP level was evaluated for the low-CRP group (CRP≤10 mg/L) versus the high-CRP group (CRP>10 mg/L). The prognostic value of the International Prognostic Index (IPI) and the Korean Prognostic Index (KPI) were evaluated and compared with the newly developed prognostic model. Results Patients in the high-CRP group tended to display increased adverse clinical characteristics, lower rates of complete remission (P<0.001), inferior progression-free survival (PFS, P = 0.001), and inferior overall survival (OS, P<0.001). Multivariate analysis demonstrated that elevated serum CRP levels, age >60 years, hypoalbuminemia, and elevated lactate dehydrogenase levels were independent adverse predictors of OS. Based on these four independent predictors, we constructed a new prognostic model that identified 4 groups with varying OS: group 1, no adverse factors; group 2, 1 factor; group 3, 2 factors; and group 4, 3 or 4 factors (P<0.001). The novel prognostic model was found to be superior to both the IPI in discriminating patients with different outcomes in the IPI low-risk group and the KPI in distinguishing between the low- and intermediate-low-risk groups, the intermediate-low- and high-intermediate-risk groups, and the high-intermediate- and high-risk groups. Conclusions Our results suggest that pretreatment serum CRP levels represent an independent predictor of clinical outcome for patients with ENKTL. The prognostic value of the new prognostic model is superior to both IPI and KPI. PMID:23724031

Secondary central nervous system relapse in diffuse large B cell lymphoma in a resource limited country: result from the Thailand nationwide multi-institutional registry.

PubMed

Wudhikarn, Kitsada; Bunworasate, Udomsak; Julamanee, Jakrawadee; Lekhakula, Arnuparp; Chuncharunee, Suporn; Niparuck, Pimjai; Ekwattanakit, Supachai; Khuhapinant, Archrob; Norasetthada, Lalita; Nawarawong, Weerasak; Makruasi, Nisa; Kanitsap, Nonglak; Sirijerachai, Chittima; Chansung, Kanchana; Wong, Peerapon; Numbenjapon, Tontanai; Prayongratana, Kannadit; Suwanban, Tawatchai; Wongkhantee, Somchai; Praditsuktavorn, Pannee; Intragumtornchai, Tanin

2017-01-01

Secondary central nervous system (CNS) relapse is a serious and fatal complication of diffuse large B cell lymphoma (DLBCL). Data on secondary CNS (SCNS) relapse were mostly obtained from western countries with limited data from developing countries. We analyzed the data of 2034 newly diagnosed DLBCL patients enrolled into the multi-center registry under Thai Lymphoma Study Group from setting. The incidence, September 2006 to December 2013 to represent outcome from a resource limited pattern, management, and outcome of SCNS relapse were described. The 2-year cumulative incidence (CI) of SCNS relapse was 2.7 %. A total of 729, 1024, and 281 patients were classified as low-, intermediate-, and high-risk CNS international prognostic index (CNS-IPI) with corresponding 2-year CI of SCNS relapse of 1.5, 3.1, and 4.6 %, respectively (p < 0.001). Univariate analysis demonstrated advance stage disease, poor performance status, elevated lactate dehydrogenase, presence of B symptoms, more than one extranodal organ involvement, high IPI, and high CNS-IPI group as predictive factors for SCNS relapse. Rituximab exposure and intrathecal chemoprophylaxis offered no protective effect against SCNS relapse. At the time of analysis, six patients were alive. Median OS in SCNS relapsed patients was significantly shorter than relapsed patients without CNS involvement (13.2 vs 22.6 months) (p < 0.001). Primary causes of death were progressive disease (n = 35, 63.6 %) and infection (n = 9, 16.7 %). In conclusion, although the incidence of SCNS relapse in our cohort was low, the prognosis was dismal. Prophylaxis for SCNS involvement was underused even in high-risk patients. Novel approaches for SCNS relapse prophylaxis and managements are warranted.

The IGY Gold History Preservation Program

NASA Astrophysics Data System (ADS)

Thompson, B. J.; Cliver, E. W.; Gentile, L. C.; Sigsbee, K. M.; Doel, R. E.

2006-05-01

An important part of the 2007 International Year activities will be preserving the history and memory of IGY 1957. The "IGY Gold" History initiative has several goals: 1) identifying and recognizing planners of and participants in the first IGY, 2) preserving memoirs, articles, photographs, and all items of historical significance for the IGY, 3) making these items available to historians, researchers, etc., 4) serving as a contact service for these activities, 5) spreading awareness of the history of geophysics, and 6) planning special events and "reunions." The IGY "Gold" Club identifies participants from the first IGY (gold symbolizing the 50th anniversary). "Gold club" participants will be rewarded with a special "IGY Gold Anniversary" certificate of recognition and a special commemorative "IGY Gold" lapel pin. Many IGY participants from around the globe have received IGY Gold Club awards, and many have submitted valuable historical material about the IGY activities. This is a joint program of the IHY, eGY, IPY, IYPE and IUGG.

Building AN International Polar Data Coordination Network

NASA Astrophysics Data System (ADS)

Pulsifer, P. L.; Yarmey, L.; Manley, W. F.; Gaylord, A. G.; Tweedie, C. E.

2013-12-01

In the spirit of the World Data Center system developed to manage data resulting from the International Geophysical Year of 1957-58, the International Polar Year 2007-2009 (IPY) resulted in significant progress towards establishing an international polar data management network. However, a sustained international network is still evolving. In this paper we argue that the fundamental building blocks for such a network exist and that the time is right to move forward. We focus on the Arctic component of such a network with linkages to Antarctic network building activities. A review of an important set of Network building blocks is presented: i) the legacy of the IPY data and information service; ii) global data management services with a polar component (e.g. World Data System); iii) regional systems (e.g. Arctic Observing Viewer; iv) nationally focused programs (e.g. Arctic Observing Viewer, Advanced Cooperative Arctic Data and Information Service, Polar Data Catalogue, Inuit Knowledge Centre); v) programs focused on the local (e.g. Exchange for Local Observations and Knowledge of the Arctic, Geomatics and Cartographic Research Centre). We discuss current activities and results with respect to three priority areas needed to establish a strong and effective Network. First, a summary of network building activities reports on a series of productive meetings, including the Arctic Observing Summit and the Polar Data Forum, that have resulted in a core set of Network nodes and participants and a refined vision for the Network. Second, we recognize that interoperability for information sharing fundamentally relies on the creation and adoption of community-based data description standards and data delivery mechanisms. There is a broad range of interoperability frameworks and specifications available; however, these need to be adapted for polar community needs. Progress towards Network interoperability is reviewed, and a prototype distributed data systems is demonstrated. We discuss remaining challenges. Lastly, to establish a sustainable Arctic Data Coordination Network (ADCN) as part of a broader polar Network will require adequate continued resources. We conclude by outlining proposed business models for the emerging Arctic Data Coordination Network and a broader polar Network.

Teacher Perceptions of School Consultant Social Influence Strategies: Replication and Expansion

ERIC Educational Resources Information Center

Owens, Julie Sarno; Schwartz, Madeline E.; Erchul, William P.; Himawan, Lina; Evans, Steven W.; Coles, Erika K.; Schulte, Ann C.

2017-01-01

The goals were to (a) replicate the findings of Erchul, Raven, and Whichard (2001) with regard to the Consultee/Teacher Version of the Interpersonal Power Inventory (IPI; Raven, Schwarzwald, & Koslowsky, 1998), and (b) advance the literature by examining IPI scores about a current consultation relationship. Sample 1 included 99 elementary…

Ethanol induced astaxanthin accumulation and transcriptional expression of carotenogenic genes in Haematococcus pluvialis.

PubMed

Wen, Zewen; Liu, Zhiyong; Hou, Yuyong; Liu, Chenfeng; Gao, Feng; Zheng, Yubin; Chen, Fangjian

2015-10-01

Haematococcus pluvialis is one of the most promising natural sources of astaxanthin. However, inducing the accumulation process has become one of the primary obstacles in astaxanthin production. In this study, the effect of ethanol on astaxanthin accumulation was investigated. The results demonstrated that astaxanthin accumulation occurred with ethanol addition even under low-light conditions. The astaxanthin productivity could reach 11.26 mg L(-1) d(-1) at 3% (v/v) ethanol, which was 2.03 times of that of the control. The transcriptional expression patterns of eight carotenogenic genes were evaluated using real-time PCR. The results showed that ethanol greatly enhanced transcription of the isopentenyl diphosphate (IPP) isomerase genes (ipi-1 and ipi-2), which were responsible for isomerization reaction of IPP and dimethylallyl diphosphate (DMAPP). This finding suggests that ethanol induced astaxanthin biosynthesis was up-regulated mainly by ipi-1 and ipi-2 at transcriptional level, promoting isoprenoid synthesis and substrate supply to carotenoid formation. Thus ethanol has the potential to be used as an effective reagent to induce astaxanthin accumulation in H. pluvialis. Copyright © 2015 Elsevier Inc. All rights reserved.

A Strategy for Architecture Design of Crystalline Perovskite Light-Emitting Diodes with High Performance.

PubMed

Shi, Yifei; Wu, Wen; Dong, Hua; Li, Guangru; Xi, Kai; Divitini, Giorgio; Ran, Chenxin; Yuan, Fang; Zhang, Min; Jiao, Bo; Hou, Xun; Wu, Zhaoxin

2018-06-01

All present designs of perovskite light-emitting diodes (PeLEDs) stem from polymer light-emitting diodes (PLEDs) or perovskite solar cells. The optimal structure of PeLEDs can be predicted to differ from PLEDs due to the different fluorescence dynamics and crystallization between perovskite and polymer. Herein, a new design strategy and conception is introduced, "insulator-perovskite-insulator" (IPI) architecture tailored to PeLEDs. As examples of FAPbBr 3 and MAPbBr 3 , it is experimentally shown that the IPI structure effectively induces charge carriers into perovskite crystals, blocks leakage currents via pinholes in the perovskite film, and avoids exciton quenching simultaneously. Consequently, as for FAPbBr 3 , a 30-fold enhancement in the current efficiency of IPI-structured PeLEDs compared to a control device with poly(3,4ethylenedioxythiophene):poly(styrene sulfonate) as hole-injection layer is achieved-from 0.64 to 20.3 cd A -1 -while the external quantum efficiency is increased from 0.174% to 5.53%. As the example of CsPbBr 3 , compared with the control device, both current efficiency and lifetime of IPI-structured PeLEDs are improved from 1.42 and 4 h to 9.86 cd A -1 and 96 h. This IPI architecture represents a novel strategy for the design of light-emitting didoes based on various perovskites with high efficiencies and stabilities. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PolarTREC—A Model Program for Taking Polar Literacy into the Future

NASA Astrophysics Data System (ADS)

Warburton, J.; Timm, K.; Larson, A. M.

2009-12-01

Polar TREC—Teachers and Researchers Exploring and Collaborating, is a three-year (2007-2009) NSF-funded International Polar Year (IPY) teacher professional development program that advances Science, Technology, Engineering, and Mathematics (STEM) education by improving teacher content knowledge and instructional practices through Teacher Research Experiences (TRE) in the Arctic and Antarctic. Leveraging profound changes and fascinating science taking place in the polar regions, PolarTREC broadly disseminates activities and products to students, educators, researchers, and the public, connecting them with the Arctic and Antarctica and sustaining the widespread interest in the polar regions and building on the enthusiasm that was generated through IPY. Central to the PolarTREC Teacher Research Experience Model, over 40 teachers have spent two to eight weeks participating in hands-on research in the polar regions and sharing their experiences with diverse audiences via live events, online multimedia journals, and interactive bulletin boards. The Connecting Arctic/Antarctic Researchers and Educators (CARE) Network unifies learning community members participants, alumni, and others, developing a sustainable association of education professionals networking to share and apply polar STEM content and pedagogical skills. Educator and student feedback from preliminary results of the program evaluation has shown that PolarTREC’s comprehensive program activities have many positive impacts on educators and their ability to teach science concepts and improve their teaching methods. Additionally, K-12 students polled in interest surveys showed significant changes in key areas including amount of time spent in school exploring research activities, importance of understanding science for future work, importance of understanding the polar regions as a person in today’s world, as well as increased self-reported knowledge and interest in numerous science content areas. Building on previous programs and successes, PolarTREC has developed a successful internet based program for teachers and researchers to interact, leveraging their diverse experiences and expertise for the creation of interdisciplinary educational tools including online journals and forums, real-time Internet seminars, lesson plans, classroom activities, audio, video, and other highly relevant and adaptable educational resources that address a broad range of scientific topics. These highly accessible methods and resources are available to educators and students of varying ages and abilities across the globe, and have connected thousands of students and citizens to the excitement of polar science. PolarTREC provides a tested approach and a clear route for varying levels of researcher participation in the education community, therefore facilitating the types of positive benefits and understanding that ensure increased educator, student, and community understanding of science and the polar regions during times of interrelated global change. For more information, email info@polartrec.com or call 907-474-1600.

International Power Institute`s quarterly technical progress report, July--September 1998

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coles, J.E.

1998-10-30

The International Power Institute (IPI) at Morehouse College has organized a team to design and create a Short Term Training Program for ESKOM Union Leaders which will last four weeks and take place at a location in South Africa to be designated by ESKOM. This proposal envisions a group of no more than 25 union leaders to be trained at the same time but the program could be expanded to accommodate up to 40 trainees. The program is designed around interactive training with lectures followed by discussion, case studies, trainee work groups, homework assignments and two field study visits. Also,more » the program is designed to have a number of ESKOM management people join the course for one day in the second week and one day at the end, in each case after a half day of preparation in separate sessions from the union leaders, to share with the trainees expectations and, at the end of the program, their course experiences. In addition, IPI has prepared a follow on proposal for a Long Term Training Program. This LT program is specified in less detail but can be expanded based on future discussions with ESKOM management. The training program is designed with the following objectives: determine and identify the most pressing problems facing ESKOM Union Leadership in their relationship with management; instill in the union leadership a heightened sense of purpose and willingness to take ownership of a process that will increase effective outcomes of meaningful, good faith bargaining; develop skills and experience leading to improved union administration; enhance realistic expectations and improve process knowledge to facilitate future labor negotiations and grievance proceedings; and provide participants with enhanced skills and knowledge to develop and/or strengthen a functioning, democratic work culture and structure internal to the union.« less

The phage integrase vector pIPI03 allows RecA-independent, site-specific labelling of Staphylococcus lugdunensis strains.

PubMed

Heilbronner, Simon; Monk, Ian R; Foster, Timothy J

2013-11-01

Staphylococcus lugdunensis is a coagulase negative staphylococcus that is a commensal of man and an opportunistic pathogen. A site-specific integrative plasmid for the use in S. lugdunensis was constructed and validated. The integrase gene ccrB of bacteriophage ϕSL01 together with its attachment site was cloned into the thermosensitive plasmid pIMAY. The resulting plasmid pIPI03 integrated RecA-independently, site-specifically and irreversibly into the S. lugdunensis chromosome. Two IPTG-inducible antibiotic resistance determinants were cloned into pIPI03 and the derivatives were used to construct strains suitable for competitive growth experiments in both in vitro and in vivo. Copyright © 2013 Elsevier Inc. All rights reserved.

High-spin terminating states in the N = 88 Ho 155 and Er 156 isotones

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rees, J. M.; Paul, E. S.; Simpson, J.

2015-05-01

The Sn-124(Cl-37, 6n gamma) fusion-evaporation reaction at a bombarding energy of 180 MeV has been used to significantly extend the excitation level scheme of Ho-155(67)88. The collective rotational behavior of this nucleus breaks down above spin I similar to 30 and a fully aligned noncollective (band terminating) state has been identified at I-pi = 79/2(-). Comparison with cranked Nilsson-Strutinsky calculations also provides evidence for core-excited noncollective states at I-pi = 87/2(-) and (89/2(+)) involving particle-hole excitations across the Z = 64 shell gap. A similar core-excited state in Er-156(68)88 at I-pi = (46(+)) is also presented.

AGR-5/6/7 Irradiation Test Predictions using PARFUME

DOE Office of Scientific and Technical Information (OSTI.GOV)

Skerjanc, William F.

PARFUME, (PARticle FUel ModEl) a fuel performance modeling code used for high temperature gas-cooled reactors (HTGRs), was used to model the Advanced Gas Reactor (AGR)-5/6/7 irradiation test using predicted physics and thermal hydraulics data. The AGR-5/6/7 test consists of the combined fifth, sixth, and seventh planned irradiations of the AGR Fuel Development and Qualification Program. The AGR-5/6/7 test train is a multi-capsule, instrumented experiment that is designed for irradiation in the 133.4-mm diameter north east flux trap (NEFT) position of Advanced Test Reactor (ATR). Each capsule contains compacts filled with uranium oxycarbide (UCO) unaltered fuel particles. This report documents themore » calculations performed to predict the failure probability of tristructural isotropic (TRISO)-coated fuel particles during the AGR-5/6/7 experiment. In addition, this report documents the calculated source term from the driver fuel. The calculations include modeling of the AGR-5/6/7 irradiation that is scheduled to occur from October 2017 to April 2021 over a total of 13 ATR cycles, including nine normal cycles and four Power Axial Locator Mechanism (PALM) cycle for a total between 500 – 550 effective full power days (EFPD). The irradiation conditions and material properties of the AGR-5/6/7 test predicted zero fuel particle failures in Capsules 1, 2, and 4. Fuel particle failures were predicted in Capsule 3 due to internal particle pressure. These failures were predicted in the highest temperature compacts. Capsule 5 fuel particle failures were due to inner pyrolytic carbon (IPyC) cracking causing localized stresses concentrations in the SiC layer. This capsule predicted the highest particle failures due to the lower irradiation temperature. In addition, shrinkage of the buffer and IPyC layer during irradiation resulted in formation of a buffer-IPyC gap. The two capsules at the two ends of the test train, Capsules 1 and 5 experienced the smallest buffer-IPyC gap formation due to the lower irradiation fluences and temperatures. Capsule 3 experienced the largest buffer-IPyC gap formation of just under 24 µm. The release fraction of fission products Ag, Cs, and Sr silver (Ag), cesium (Cs), and strontium (Sr) vary depending on capsule location and irradiation temperature. The maximum release fraction of Ag occurs in Capsule 3, reaching up to 84.8% for the TRISO fuel particles. The release fraction of the other two fission products, Cs and Sr are much smaller and, in most cases, less than 1%. The notable exception is again in Capsule 3, where the release fraction for Cs and Sr reach up to 9.7% and 19.1%, respectively.« less

Temporal-pattern recognition by single neurons in a sensory pathway devoted to social communication behavior

PubMed Central

Carlson, Bruce A.

2010-01-01

Sensory systems often encode stimulus information into the temporal pattern of action potential activity. However, little is known about how the information contained within these patterns is extracted by postsynaptic neurons. Similar to temporal coding by sensory neurons, social information in mormyrid fish is encoded into the temporal patterning of an electric organ discharge (EOD). In the current study, sensitivity to temporal patterns of electrosensory stimuli was found to arise within the midbrain posterior exterolateral nucleus (ELp). Whole-cell patch recordings from ELp neurons in vivo revealed three patterns of interpulse interval (IPI) tuning: low-pass neurons tuned to long intervals, high-pass neurons tuned to short intervals and band-pass neurons tuned to intermediate intervals. Many neurons within each class also responded preferentially to either increasing or decreasing IPIs. Playback of electric signaling patterns recorded from freely behaving fish revealed that the IPI and direction tuning of ELp neurons resulted in selective responses to particular social communication displays characterized by distinct IPI patterns. The postsynaptic potential responses of many neurons indicated a combination of excitatory and inhibitory synaptic input, and the IPI tuning of ELp neurons was directly related to rate-dependent changes in the direction and amplitude of postsynaptic potentials. These results suggest that differences in the dynamics of short-term synaptic plasticity in excitatory and inhibitory pathways may tune central sensory neurons to particular temporal patterns of presynaptic activity. This may represent a general mechanism for the processing of behaviorally-relevant stimulus information encoded into temporal patterns of activity by sensory neurons. PMID:19641105

Temporal-pattern recognition by single neurons in a sensory pathway devoted to social communication behavior.

PubMed

Carlson, Bruce A

2009-07-29

Sensory systems often encode stimulus information into the temporal pattern of action potential activity. However, little is known about how the information contained within these patterns is extracted by postsynaptic neurons. Similar to temporal coding by sensory neurons, social information in mormyrid fish is encoded into the temporal patterning of an electric organ discharge. In the current study, sensitivity to temporal patterns of electrosensory stimuli was found to arise within the midbrain posterior exterolateral nucleus (ELp). Whole-cell patch recordings from ELp neurons in vivo revealed three patterns of interpulse interval (IPI) tuning: low-pass neurons tuned to long intervals, high-pass neurons tuned to short intervals, and bandpass neurons tuned to intermediate intervals. Many neurons within each class also responded preferentially to either increasing or decreasing IPIs. Playback of electric signaling patterns recorded from freely behaving fish revealed that the IPI and direction tuning of ELp neurons resulted in selective responses to particular social communication displays characterized by distinct IPI patterns. The postsynaptic potential responses of many neurons indicated a combination of excitatory and inhibitory synaptic input, and the IPI tuning of ELp neurons was directly related to rate-dependent changes in the direction and amplitude of postsynaptic potentials. These results suggest that differences in the dynamics of short-term synaptic plasticity in excitatory and inhibitory pathways may tune central sensory neurons to particular temporal patterns of presynaptic activity. This may represent a general mechanism for the processing of behaviorally relevant stimulus information encoded into temporal patterns of activity by sensory neurons.

Activity of IPI-504, a Novel Heat-Shock Protein 90 Inhibitor, in Patients With Molecularly Defined Non–Small-Cell Lung Cancer

PubMed Central

Sequist, Lecia V.; Gettinger, Scott; Senzer, Neil N.; Martins, Renato G.; Jänne, Pasi A.; Lilenbaum, Rogerio; Gray, Jhanelle E.; Iafrate, A. John; Katayama, Ryohei; Hafeez, Nafeeza; Sweeney, Jennifer; Walker, John R.; Fritz, Christian; Ross, Robert W.; Grayzel, David; Engelman, Jeffrey A.; Borger, Darrell R.; Paez, Guillermo; Natale, Ronald

2010-01-01

Purpose IPI-504 is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90). Its potential anticancer activity has been validated in preclinical in vitro and in vivo models. We studied the activity of IPI-504 after epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy in patients with advanced, molecularly defined non–small-cell lung cancer (NSCLC). Patients and Methods Patients with advanced NSCLC, prior treatment with EGFR TKIs, and tumor tissue available for molecular genotyping were enrolled in this prospective, nonrandomized, multicenter, phase II study of IPI-504 monotherapy. The primary outcome was objective response rate (ORR). Secondary aims included safety, progression-free survival (PFS), and analysis of activity by molecular subtypes. Results Seventy-six patients were enrolled between December 2007 and May 2009 from 10 United States cancer centers. An ORR of 7% (five of 76) was observed in the overall study population, 10% (four of 40) in patients who were EGFR wild-type, and 4% (one of 28) in those with EGFR mutations. Although both EGFR groups were below the target ORR of 20%, among the three patients with an ALK gene rearrangement, two had partial responses and the third had prolonged stable disease (7.2 months, 24% reduction in tumor size). The most common adverse events included grades 1 and 2 fatigue, nausea, and diarrhea. Grade 3 or higher liver function abnormalities were observed in nine patients (11.8%). Conclusion IPI-504 has clinical activity in patients with NSCLC, particularly among patients with ALK rearrangements. PMID:20940188

Generalizability of clinical trials of advanced melanoma in the real-world, population-based setting.

PubMed

Sam, Davis; Gresham, Gillian; Abdel-Rahman, Omar; Cheung, Winson Y

2018-06-18

Results from novel therapeutics trials are not always generalizable to real-world patients. We aimed to determine the pattern in which trial findings are applied in a population-based setting of melanoma patients and consequent treatment outcomes. Patients with unresectable disease during 2011-2014 and referred to cancer centers in a large Canadian province were retrospectively reviewed. Based on eligibility criteria as described in registration trials of vemurafenib (Vem) and ipilimumab (Ipi), we classified patients into trial-eligible and ineligible and those treated and untreated with these agents. We identified 290 patients with known BRAF status for the Vem analysis and 212 patients previously treated with first-line agents for the Ipi analysis. For the Vem cohort, a total of 49 patients were considered trial-eligible, of whom 36 (73%) received treatment. For the Ipi cohort, there were 119 trial-eligible cases of whom 43 (36%) received therapy. Factors other than eligibility criteria most frequently associated with non-treatment in these cohorts included concerns regarding treatment harm and patient preferences. In multivariable analysis, overall survival was improved in Vem cohort patients considered trial-eligible and treated compared to those who were ineligible. Within the Ipi cohort, survival was improved in trial-eligible patients regardless of whether they received Ipi compared to ineligible patients. Real-world uptake of new melanoma treatments was suboptimal, and non-use in trial-eligible patients was frequent. Future clinical trials that are more pragmatically designed to include participants who better reflect the real-world population may facilitate increased uptake of novel therapeutics into routine clinical practice.

Prevalence of intestinal parasites versus knowledge, attitudes, and practices of inhabitants of low-income communities of Campos dos Goytacazes, Rio de Janeiro State, Brazil.

PubMed

de Moraes Neto, Antonio Henrique A; Pereira, Adriana P M F; Alencar, Maria de Fátima L; Souza, Paulo R B; Dias, Rodrigo C; Fonseca, Juliana G; Santos, Clóvis P; Almeida, João C A

2010-07-01

Intestinal parasites are the causative agents of common infections responsible for significant public health problems in developing countries and generally linked to lack of sanitation, safe water, and improper hygiene. More than two billion people throughout the world live with unrelenting illness due to intestinal parasitic infections (IPIs). The purposes of this study are to assess knowledge, attitudes, and practices on IPIs and investigate the relationship with prevalence of intestinal parasites among a low-income group of inhabitants from two communities of the Travessão District area, Campos dos Goytacazes, north of Rio de Janeiro State, Brazil. The two communities are known as "Parque Santuário," which is an urban slum with miserable living conditions, and "Arraial," where the socioeconomic and educational levels are better, neither having a sanitary infrastructure with an excreta collection system. Questionnaires revealed that both communities had local and specific codification to denominate the intestinal parasites and present correct knowledge on the theme but ignored some aspects of IPI transmission, with the Arraial population being better informed (p < 0.05). The overall prevalence of IPIs in Parque Santuário (49.7%) was greater than in Arraial (27.2%) (p < 0.001; prevalence ratio/95% confidence interval 1.83/1.50-2.23). This study reports the real IPI situation in the Travessão District and also reinforces the need to continue the investigation on the impact of combined prophylactic methods, educational measures, and socioeconomic and sanitary improvements by governmental authorities and the local popular organization.

Environmental aspects related to tuberculosis and intestinal parasites in a low-income community of the Brazilian Amazon

PubMed Central

Cardoso, Biatriz Araújo; Fonseca, Fabio de Oliveira; de Moraes, Antonio Henrique Almeida; Martins, Ana Caroline Guedes Souza; Oliveira, Nissa Vilhena da Silva; Lima, Luana Nepomuceno Gondim Costa; Dias, George Alberto da Silva; Saad, Maria Helena Féres

2017-01-01

ABSTRACT We carried out a cross-sectional study from January to December 2015 on 1,425 inhabitants from a floating population in the Brazilian Amazon (Murinin district, Pará State) to describe the population-based prevalence of tuberculosis (TB) from 2011 to 2014, recent TB contacts (rCts) latently infected with Mycobacterium tuberculosis (LTBI) , the coverage of the local health network, socio-environmental factors, and frequency of intestinal parasitic infection (IPI). We found that the sanitary structure was inadequate, with latrines being shared with other rooms within the same accommodation; well water was the main source of water, and 48% of families had low incomes. The average rate of TB was 105/100, 000 inhabitants per year; one third of TB patients had been household contacts of infected individuals in the past, and 23% of rCts were LTBI. More than half (65%) of 44% of the stools examined (representing 76% of the housing) had IPIs; the highest prevalence was of fecal-oral transmitted protozoa (40%, Giardia intestinalis ), followed by soil-transmitted helminths (23%). TB transmission may be related to insufficient disease control of rCts, frequent relocation, and underreporting. Education, adopting hygienic habits, improving sanitation, provision of a treated water supply and efficient sewage system, further comprehensive epidemiological surveillance of those who enter and leave the community and resources for basic treatment of IPIs are crucial in combating the transmission of these neglected diseases. PMID:28793025

Environmental aspects related to tuberculosis and intestinal parasites in a low-income community of the Brazilian Amazon.

PubMed

Cardoso, Biatriz Araújo; Fonseca, Fabio de Oliveira; Moraes, Antonio Henrique Almeida de; Martins, Ana Caroline Guedes Souza; Oliveira, Nissa Vilhena da Silva; Lima, Luana Nepomuceno Gondim Costa; Dias, George Alberto da Silva; Saad, Maria Helena Féres

2017-08-07

We carried out a cross-sectional study from January to December 2015 on 1,425 inhabitants from a floating population in the Brazilian Amazon (Murinin district, Pará State) to describe the population-based prevalence of tuberculosis (TB) from 2011 to 2014, recent TB contacts (rCts) latently infected with Mycobacterium tuberculosis (LTBI) , the coverage of the local health network, socio-environmental factors, and frequency of intestinal parasitic infection (IPI). We found that the sanitary structure was inadequate, with latrines being shared with other rooms within the same accommodation; well water was the main source of water, and 48% of families had low incomes. The average rate of TB was 105/100, 000 inhabitants per year; one third of TB patients had been household contacts of infected individuals in the past, and 23% of rCts were LTBI. More than half (65%) of 44% of the stools examined (representing 76% of the housing) had IPIs; the highest prevalence was of fecal-oral transmitted protozoa (40%, Giardia intestinalis ), followed by soil-transmitted helminths (23%). TB transmission may be related to insufficient disease control of rCts, frequent relocation, and underreporting. Education, adopting hygienic habits, improving sanitation, provision of a treated water supply and efficient sewage system, further comprehensive epidemiological surveillance of those who enter and leave the community and resources for basic treatment of IPIs are crucial in combating the transmission of these neglected diseases.

[The clinical characteristics and prognostic analysis of gastric mucosa-associated lymphoid tissue lymphoma of 103 cases].

PubMed

Li, Xiao-wu; Xia, Bing; Guo, Qing; Jin, Xin; Yu, Yong; Zhao, Zhi-gang; Wang, Xiao-fang; Wang, Ya-fei; Zhang, Yi-zhuo

2012-10-01

To analyze the clinical characteristics and prognosis of the patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma. The clinical characteristics and prognostic factors of 103 gastric MALT lymphoma patients admitted to our hospital from April 2001 to August 2011 were retrospectively analyzed. The onset of gastric MALT lymphoma was often insidious without specific clinical manifestation, the most common complaints were abdominal pain or discomfort, weight loss, poor appetite, nausea and vomiting. According to Musshoff staging system, 75(72.8%) patients were at early stages (I/II) and 28 (27.2%) patients at advanced stages (III/IV). There was no significant difference in five-year overall survival (OS) between the patients in surgery group and non-surgery group (60.4% vs 78.9%, respectively, P = 0072), while there was statistical difference in five-year progression-free survival (PFS) between the two groups (31.7% vs 52.8%, respectively, P = 0.023). Helicobacter pylori (Hp) was detected in 94 patients (91.2%). Anti-Hp treatment was effective with 100% overall response rate. In 94 patients with complete follow-up data, the 5-year OS rate was 75%, 5-year PFS rate was 46%. Univariate survival analysis showed that the B symptoms, Musshoff staging, performance staging, stage-modified IPI, levels of LDH, nodal involvement and levels of β(2)-microglobulin were correlated with OS and PFS (P < 0.05). The Cox regression analysis showed that Musshoff-III/IV stage, stage-modified IPI score > 2 and B symptoms were independent factor for OS (P < 0.05), whereas Musshoff-III/IV stage was independent factor for PFS (P = 0.027). The gastric MALT lymphoma had a favorable outcome with high OS rate. The anti-Hp therapy was an effective treatment for the gastric MALT lymphoma, which avoid the surgical trauma and improve the quality of life. The prognostic analysis showed that Musshoff staging, B symptoms or stage-modified IPI score were independent factors for OS and Musshoff staging was also an independent factor for PFS.

Virtually Shaping the Future of Polar Research

NASA Astrophysics Data System (ADS)

Baeseman, J. L.; Koldunov, N. V.; Jochum, K.

2009-12-01

The Association of Polar Early Career Scientists (APECS) is an international and interdisciplinary organization for undergraduate and graduate students, postdoctoral researchers, early faculty members, educators and others with interests in Polar Regions and the wider cryosphere that started as a result of the International Polar Year (IPY). APECS is leading the way for virtual communication of polar research through several activities: an online Polar Literature Discussion Forum, a Virtual Poster Session, and Communication beyond the conference setting. APECS has created an extensive online discussion forum where researchers share both classic and cutting-edge literature articles and critique techniques that were used by authors, helping to improve methods as well as discover new ways to approach polar research questions. Many researchers present their results as posters at conferences. APECS has taken this process to a new level by creating a format to display previously presented posters online instead of these files simply sitting on a researcher’s hard-drive. Not only are the posters online, a monthly conference call open to hundreds of participants allows researchers to share their work with a new audience - fellow researchers, community members, potential colleagues, policy makers and educators. These calls are recorded and archived online so the next time someone visits the poster, they can hear the researcher describe their work and communicate with the researcher questions they may have, potential ways to collaborate or share different methodologies to improve future endeavors. Peer-reviewed literature articles are the currency of science and APECS has capitalized on this by creating a way for researchers to increase the exposure of their publications beyond the table of contents published by journals. The Polar Literature Discussion Forum is a new way for researchers to share their papers, as well as discuss classic articles. This has become a popular place where IPY related research is being archived in a non-traditional manner. Researchers are sharing not only their papers, but insights on data collection and how other researchers could improve on what they have done during the IPY. The IPY has created many new research projects and stimulated new questions and created cutting-edge techniques to address these problems. APECS is helping to carry on these discussions beyond the typical conference settings directly to a researcher’s office or at home on their couch. These communication tools will help to stimulate discussion carrying forward the research questions addressed and created during the IPY.

Inter-Pregnancy Intervals and the Risk of Autism Spectrum Disorder: Results of a Population-Based Study

ERIC Educational Resources Information Center

Durkin, Maureen S.; DuBois, Lindsay A.; Maenner, Matthew J.

2015-01-01

Recent studies have reported an increased risk of autism among second-born children conceived <12 versus >36 months after the birth of a sibling. Confirmation of this finding would point to inter-pregnancy interval (IPI) as a potentially modifiable risk factor for autism. This study evaluated the relationship between IPI and autism spectrum…

‘Antarctic biology in the 21st century - Advances in, and beyond the international polar year 2007-2008’

NASA Astrophysics Data System (ADS)

Stoddart, Michael

2010-08-01

The International Polar Year 2007-2008 (IPY) has provided an opportunity for biology to show itself as an important part of Antarctic science in a manner in which it was not seen during earlier Polar Years. Of the 15 endorsed biological projects in Antarctica, 7 included more than 20 scientists and could be deemed truly international. Four were conducted in the marine environment, and one each in the fields of biological invasions, microbial ecology, and terrestrial ecology, and one was SCAR’s over-arching ‘Evolution and Biodiversity in the Antarctic’. The marine projects have left a robust legacy of data for future research into the consequences of environmental change, and into future decisions about marine protected areas. Studies on introductions of exotic organisms reveal an ever-present threat to the warmer parts of the high-latitude Southern Ocean, or parts which might become warmer with climate change. Studies on microbial ecology reveal great complexity of ecosystems with high numbers of unknown species. Terrestrial research has shown how vulnerable the Antarctic is to accidental introductions, and how productive the soils can be under changed climate conditions. Antarctic biology has come-of-age during IPY 2007-2008 and the campaign has set the scene for future research.

The Permafrost Young Researchers Network (PYRN): Contribution to IPY's "Thermal State of Permafrost"

NASA Astrophysics Data System (ADS)

Johansson, M.; Lantuit, H.; Frauenfeld, O. W.

2007-12-01

The Permafrost Young Researchers Network (PYRN, www.pyrn.org) is a unique resource for students, young scientists, and engineers studying permafrost. It is an international organization fostering innovative collaboration, seeking to recruit, retain, and promote future generations of permafrost scientists and engineers. Initiated for and during IPY, PYRN directs the multi-disciplinary talents of its membership toward global awareness, knowledge, and response to permafrost-related challenges in a changing climate. Created as an education and outreach component of the International Permafrost Association (IPA), PYRN is a central database of permafrost information and science for more than 350 young researchers from 33 countries. PYRN distributes a newsletter, recognizes outstanding permafrost research by its members through an annual awards program, organizes training workshops (2007 in Abisko, Sweden and St. Petersburg, Russia), and contributes to the growth and future of the permafrost community. While networking forms the basis of PYRN's activities, the organization also seeks to establish itself as a driver of permafrost research for the IPY and beyond. We recently launched a series of initiatives on several continents aimed at providing young scientists and engineers with the means to conduct ground temperature monitoring in under-investigated permafrost regions. Focusing on sites not currently covered by the IPA's "Thermal State of Permafrost" project, the young investigators of PYRN will provide and use lightweight drills and temperature sensors to instrument shallow boreholes in those regions. The data and results will be incorporated in the global database on permafrost temperatures and made freely available to the scientific community, thereby contributing to the advance of permafrost science and the strengthening of the next generation of permafrost researchers.

A computer-human interaction model to improve the diagnostic accuracy and clinical decision-making during 12-lead electrocardiogram interpretation.

PubMed

Cairns, Andrew W; Bond, Raymond R; Finlay, Dewar D; Breen, Cathal; Guldenring, Daniel; Gaffney, Robert; Gallagher, Anthony G; Peace, Aaron J; Henn, Pat

2016-12-01

The 12-lead Electrocardiogram (ECG) presents a plethora of information and demands extensive knowledge and a high cognitive workload to interpret. Whilst the ECG is an important clinical tool, it is frequently incorrectly interpreted. Even expert clinicians are known to impulsively provide a diagnosis based on their first impression and often miss co-abnormalities. Given it is widely reported that there is a lack of competency in ECG interpretation, it is imperative to optimise the interpretation process. Predominantly the ECG interpretation process remains a paper based approach and whilst computer algorithms are used to assist interpreters by providing printed computerised diagnoses, there are a lack of interactive human-computer interfaces to guide and assist the interpreter. An interactive computing system was developed to guide the decision making process of a clinician when interpreting the ECG. The system decomposes the interpretation process into a series of interactive sub-tasks and encourages the clinician to systematically interpret the ECG. We have named this model 'Interactive Progressive based Interpretation' (IPI) as the user cannot 'progress' unless they complete each sub-task. Using this model, the ECG is segmented into five parts and presented over five user interfaces (1: Rhythm interpretation, 2: Interpretation of the P-wave morphology, 3: Limb lead interpretation, 4: QRS morphology interpretation with chest lead and rhythm strip presentation and 5: Final review of 12-lead ECG). The IPI model was implemented using emerging web technologies (i.e. HTML5, CSS3, AJAX, PHP and MySQL). It was hypothesised that this system would reduce the number of interpretation errors and increase diagnostic accuracy in ECG interpreters. To test this, we compared the diagnostic accuracy of clinicians when they used the standard approach (control cohort) with clinicians who interpreted the same ECGs using the IPI approach (IPI cohort). For the control cohort, the (mean; standard deviation; confidence interval) of the ECG interpretation accuracy was (45.45%; SD=18.1%; CI=42.07, 48.83). The mean ECG interpretation accuracy rate for the IPI cohort was 58.85% (SD=42.4%; CI=49.12, 68.58), which indicates a positive mean difference of 13.4%. (CI=4.45, 22.35) An N-1 Chi-square test of independence indicated a 92% chance that the IPI cohort will have a higher accuracy rate. Interpreter self-rated confidence also increased between cohorts from a mean of 4.9/10 in the control cohort to 6.8/10 in the IPI cohort (p=0.06). Whilst the IPI cohort had greater diagnostic accuracy, the duration of ECG interpretation was six times longer when compared to the control cohort. We have developed a system that segments and presents the ECG across five graphical user interfaces. Results indicate that this approach improves diagnostic accuracy but with the expense of time, which is a valuable resource in medical practice. Copyright © 2016 Elsevier Inc. All rights reserved.

Synthesizing International Understanding of Changes in the Arctic Hydrological System

NASA Astrophysics Data System (ADS)

Pundsack, J. W.; Vorosmarty, C. J.; Hinzman, L. D.

2009-12-01

There are several notable gaps in our current level of understanding of Arctic hydrological systems. At the same time, rapidly emerging data sets, technologies, and modeling resources provide us with an unprecedented opportunity to move substantially forward. The Arctic Community-Wide Hydrological Analysis and Monitoring Program (Arctic-CHAMP), funded by NSF/ARCSS, was established to initiate a major effort to improve our current monitoring of water cycle variables, and to foster collaboration with the many relevant U.S. and international arctic research initiatives. These projects, funded under ARCSS through the ‘Freshwater Integration (FWI) study’, links CHAMP, the Arctic/Subarctic Ocean Fluxes (ASOF) Programme, and SEARCH. As part of the overall synthesis and integration efforts of the NSF-ARCSS Freshwater Integration (FWI) study, the program carried-out a major International Synthesis Capstone Workshop in Fall 2009 as an International Polar Year (IPY) affiliated meeting. The workshop, "Synthesizing International Understanding of Changes in the Arctic Hydrological System,” was held 30 September to 4 October 2009 in Stockholm at the Beijer Auditorium of the Royal Swedish Academy. The workshop was sponsored by the NSF-ARCSS Arctic-CHAMP Science Management Office (City College of New York / Univ. of New Hampshire), the International Study of Arctic Change (ISAC), and the International Arctic Research Center (IARC; Univ. of Alaska Fairbanks). The overarching goals of the meeting were to stage a post-IPY lessons-learned workshop with co-equal numbers of FWI, IPY, and ICARP-II researchers, using insights from recent scientific findings, data, and strategies to afford synthesis. The workshop aimed to: (1) take stock of recent advances in our understanding of changes in the Arctic hydrological system; (2) identify key remaining research gaps / unanswered questions; and (3) gather insight on where to focus future research efforts/initiatives (nationally and internationally). The workshop brought together approximately 40 participants, with roughly equal numbers from North America and Europe/Scandinavia, and included representatives from Canada, Russia, Germany, Iceland, Sweden, Norway, Finland, Denmark/Greenland, and the US. This talk will focus on findings of the workshop, highlighting advances in Arctic research that have taken flight over the last decade, specifically stimulated by considering the hydrologic cycle as an integrating force and fundamental building block uniting atmospheric, oceanic, cryospheric and terrestrial domains of the pan-Arctic system. The authors will present a future vision for systems-level science of Arctic hydrology and affiliated energy and carbon cycles. A scientific roadmap will be introduced, outlining the main research priorities, robust global and regional geo-information data products, improved models and effective data assimilation systems to forward the science of water in the Arctic.

GABAergic Local Interneurons Shape Female Fruit Fly Response to Mating Songs.

PubMed

Yamada, Daichi; Ishimoto, Hiroshi; Li, Xiaodong; Kohashi, Tsunehiko; Ishikawa, Yuki; Kamikouchi, Azusa

2018-05-02

Many animals use acoustic signals to attract a potential mating partner. In fruit flies ( Drosophila melanogaster ), the courtship pulse song has a species-specific interpulse interval (IPI) that activates mating. Although a series of auditory neurons in the fly brain exhibit different tuning patterns to IPIs, it is unclear how the response of each neuron is tuned. Here, we studied the neural circuitry regulating the activity of antennal mechanosensory and motor center (AMMC)-B1 neurons, key secondary auditory neurons in the excitatory neural pathway that relay song information. By performing Ca 2+ imaging in female flies, we found that the IPI selectivity observed in AMMC-B1 neurons differs from that of upstream auditory sensory neurons [Johnston's organ (JO)-B]. Selective knock-down of a GABA A receptor subunit in AMMC-B1 neurons increased their response to short IPIs, suggesting that GABA suppresses AMMC-B1 activity at these IPIs. Connection mapping identified two GABAergic local interneurons that synapse with AMMC-B1 and JO-B. Ca 2+ imaging combined with neuronal silencing revealed that these local interneurons, AMMC-LN and AMMC-B2, shape the response pattern of AMMC-B1 neurons at a 15 ms IPI. Neuronal silencing studies further suggested that both GABAergic local interneurons suppress the behavioral response to artificial pulse songs in flies, particularly those with a 15 ms IPI. Altogether, we identified a circuit containing two GABAergic local interneurons that affects the temporal tuning of AMMC-B1 neurons in the song relay pathway and the behavioral response to the courtship song. Our findings suggest that feedforward inhibitory pathways adjust the behavioral response to courtship pulse songs in female flies. SIGNIFICANCE STATEMENT To understand how the brain detects time intervals between sound elements, we studied the neural pathway that relays species-specific courtship song information in female Drosophila melanogaster We demonstrate that the signal transmission from auditory sensory neurons to key secondary auditory neurons antennal mechanosensory and motor center (AMMC)-B1 is the first-step to generate time interval selectivity of neurons in the song relay pathway. Two GABAergic local interneurons are suggested to shape the interval selectivity of AMMC-B1 neurons by receiving auditory inputs and in turn providing feedforward inhibition onto AMMC-B1 neurons. Furthermore, these GABAergic local interneurons suppress the song response behavior in an interval-dependent manner. Our results provide new insights into the neural circuit basis to adjust neuronal and behavioral responses to a species-specific communication sound. Copyright © 2018 the authors 0270-6474/18/384329-19$15.00/0.

The History of Winter: A Professional Development "Teacher as Scientist" Experiential Learning Field Experience.

NASA Astrophysics Data System (ADS)

Gabrys, R. E.

2007-12-01

Each year since 2000, the NASA Goddard History of Winter (HOW) program has allowed teachers to develop an understanding of the consequences of one segment of the orbit of the tilted Earth in its path around the sun. Scientists from NASA, CRREL, and Michigan Tech, supported by the Whiteface Observatory, and the science program at Northwood School in Lake Placid, New York, use the weather and the stratigraphy in the ice and snow, consequences of the weather changes, as "teachers" in a team study of the winter record. Snow in the air and on the ground, ice, its crystal structure and axial orientation, and the ecosystem consequences of snow and ice constitute the weeklong content package. Teacher Professional Development Standards A, B, C, and D were the guiding principles in developing HOW with a content structure formulated as protocols to serve as inserts into lesson plans and inquiry guides. The concept of HOW within NASA is to provide understanding of the WHY? and WHAT? of satellite remote sensing. The content is appropriate ground validation in that techniques presented in protocols are identical to those used by professionals who study snow pits, evaluate features in snow metamorphism, and study thin sections of ice cores drilled in ice caps and glaciers. The HOW Teacher as scientist (TAS) model is a flexible model. HOW enables teachers who are required to use inquiry-based facilitation in the classroom to experience inquiry themselves. Teachers with little science content background as well as those with Science degrees have participated in HOW working alongside of the science team. Accommodations are made through differentiation of instruction so that each group leaves with a mastery of the content that is appropriate for the transition to presentation in the classroom. Each year builds on the previous year ensuring a time series record of the history of winter-by itself a learning experience. An offshoot of the NASA Goddard Center History of Winter (HOW) Program, the Global Snowflake Network (GSN) launched in the winter of 2006 engages an international audience including both formal and informal education groups. The goal is to provide an interactive online data resource in science and education for the characterization of snowfall and related weather systems. The Global Snowflake Network has been accepted as an education outreach proposal for the International Polar Year. Collaborations with other agencies and universities also with IPY-accepted proposals are now underway. HOW and the GSN are endorsed by the NASA Goddard Education Office and many of the Goddard Snow and Ice Team scientists. Together these programs offer a unique, sustainable, and proven outreach for the Cryosphere research program. Snowflakes are like frozen data points, their shape is a record of atmospheric conditions at the time of their formation. The shapes of snowflakes vary over the winter season, with the source of a weather system and over the course of a given snowfall. The objective of the Global Snowflake Network (GSN) is to create a global ground team of teachers, students, families, and researchers worldwide to identify snowflake types during the progress of snowfalls. The result is a unique and scientifically valid resource useful to meteorology and scientific modeling of Earth's Hydrosphere. The Global Snowflake Network (GSN), simultaneously a science program and an education program is presented as a simple, scientifically valid project that has the potential to spread the IPY message and produce a lasting resource to further scientific understanding of Earth's hydrology through the study of snow.

Characteristics and associations of pain intensity in patients referred to a specialist cancer pain clinic.

PubMed

Pina, Paulo; Sabri, Elham; Lawlor, Peter G

2015-01-01

Uncontrolled cancer pain (CP) may impair quality of life. Given the multidimensional nature of CP, its poor control is often attributed to poor assessment and classification. To determine the characteristics and associations of pain intensity in a specialist CP clinic. Consecutive patients referred to the CP clinic of the Portuguese Cancer Institute (Lisbon, Portugal) had standardized initial assessments and status documentation of the following: Brief Pain Inventory ratings for 'pain now' as the outcome variable; initial pain intensity (iPI) on a 0 to 10 scale; pain mechanism (using the Douleur Neuropathique 4 tool to assess neuropathic pain); episodic pain; Eastern Cooperative Oncology Group rating; oral morphine equivalent daily dose (MEDD); Hospital Anxiety Depression Scale and Emotional Thermometer scores; and cancer diagnosis, metastases, treatment and pain duration. Univariable analyses were conducted to test the association of independent variables with iPI. Variables with P<0.1 were entered into a multivariable regression model, using backward elimination and a cut-point of P=0.2 for final model selection. Of 371 participants, 285 (77%) had moderate (4 to 6) or severe (7 to 10) iPI. The initial median MEDD was relatively low (30 mg [range 20 mg to 60 mg]). In the multivariable model, higher income, Eastern Cooperative Oncology Group rating 3 to 4, cancer diagnosis (head and neck, genitourinary and gastrointestinal), adjuvant use and initial MEDD were associated with iPI (P<0.05). The model's R2 was 18.6, which explained only 19% of iPI variance. The diversity of factors associated with pain intensity and their limited explanation of its variance underscore the biopsychosocial complexity of CP. Adequacy of CP management warrants further exploration.

ELECTRON PROBE MICROANALYSIS OF IRRADIATED AND 1600°C SAFETY-TESTED AGR-1 TRISO FUEL PARTICLES WITH LOW AND HIGH RETAINED 110MAG

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wright, Karen E.; van Rooyen, Isabella J.

2016-11-01

AGR-1 fuel Compact 4-3-3 achieved 18.63% FIMA and was exposed subsequently to a safety test at 1600°C. Two particles, AGR1-433-003 and AGR1-433-007, with measured-to-calculated 110mAg inventories of <22% and 100%, respectively, were selected for comparative electron microprobe analysis to determine whether the distribution or abundance of fission products differed proximally and distally from the deformed kernel in AGR1-433-003, and how this compared to fission product distribution in AGR1-433-007. On the deformed side of AGR1-433-003, Xe, Cs, I, Eu, Sr, and Te concentrations in the kernel buffer interface near the protruded kernel were up to six times higher than on themore » opposite, non-deformed side. At the SiC-inner pyrolytic carbon (IPyC) interface proximal to the deformed kernel, Pd and Ag concentrations were 1.2 wt% and 0.04 wt% respectively, whereas on the SiC-IPyC interface distal from the kernel deformation those elements measured 0.4 and 0.01 wt%, respectively. Palladium and Ag concentrations at the SiC-IPyC interface of AGR1-433-007 were 2.05 and 0.05 wt.%, respectively. Rare earth element concentrations at the SiC-IPyC interface of AGR1-433-007 were a factor of ten higher than at the SiC-IPyC interfaces measured in particle AGR1-433-003. Palladium permeated the SiC layer of AGR1-433-007 and the non-deformed SiC layer of AGR1-433-003.« less

Hyperfibrinogenemia is a poor prognostic factor in diffuse large B cell lymphoma.

PubMed

Niu, Jun-Ying; Tian, Tian; Zhu, Hua-Yuan; Liang, Jin-Hua; Wu, Wei; Cao, Lei; Lu, Rui-Nan; Wang, Li; Li, Jian-Yong; Xu, Wei

2018-06-02

Diffuse large B cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphomas worldwide. Previous studies indicated that hyperfibrinogenemia was a poor predictor in various tumors. The purpose of our study was to evaluate the prognostic effect of hyperfibrinogenemia in DLBCL. Data of 228 patients, who were diagnosed with DLBCL in our hospital between May 2009 and February 2016, were analyzed retrospectively. The Kaplan-Meier method and Cox regression were performed to find prognostic factors associated with progression-free survival (PFS) and overall survival (OS). Receiver operator characteristic (ROC) curve and the areas under the curve were used to evaluate the predictive accuracy of predictors. Comparison of characters between groups indicated that patients with high National Comprehensive Cancer Network-International Prognostic Index (NCCN-IPI) score (4-8) and advanced stage (III-IV) were more likely to suffer from hyperfibrinogenemia. The Kaplan-Meier method revealed that patients with hyperfibrinogenemia showed inferior PFS (P < 0.001) and OS (P < 0.001) than those without hyperfibrinogenemia. Multivariate analysis showed that hyperfibrinogenemia was an independent prognostic factor associated with poor outcomes (HR = 1.90, 95% CI: 1.15-3.16 for PFS, P = 0.013; HR = 2.65, 95% CI: 1.46-4.79 for OS, P = 0.001). We combined hyperfibrinogenemia and NCCN-IPI to build a new prognostic index (NPI). The NPI was demonstrated to have a superior predictive effect on prognosis (P = 0.0194 for PFS, P = 0.0034 for OS). Hyperfibrinogenemia was demonstrated to be able to predict poor outcome in DLBCL, especially for patients with advanced stage and high NCCN-IPI score. Adding hyperfibrinogenemia to NCCN-IPI could significantly improve the predictive effect of NCCN-IPI.

Monitoring Seasons Through Global Learning Communities

NASA Astrophysics Data System (ADS)

Sparrow, E. B.; Robin, J. H.; Jeffries, M. O.; Gordon, L. S.; Verbyla, D. L.; Levine, E. R.

2006-12-01

Monitoring Seasons through Global Learning Communities (MSTGLC) is an inquiry- and project-based project that monitors seasons, specifically their interannual variability, in order to increase K-12 students' understanding of the Earth system by providing teacher professional development in Earth system science and inquiry, and engaging K-12 students in Earth system science research relevant to their local communities that connect globally. MSTGLC connects GLOBE students, teachers, and communities, with educators and scientists from three integrated Earth systems science programs: the International Arctic Research Center, and NASA Landsat Data Continuity and Terra Satellite Missions. The project organizes GLOBE schools by biomes into eight Global Learning Communities (GLCs) and students monitor their seasons through regional based field campaigns. The project expands the current GLOBE phenology network by adapting current protocols and making them biome-specific. In addition, ice and mosquito phenology protocols will be developed for Arctic and Tropical regions, respectively. Initially the project will focus on Tundra and Taiga biomes as phenological changes are so pronounced in these regions. However, our long-term goal is to determine similar changes in other biomes (Deciduous Forest, Desert, Grasslands, Rain Forest, Savannah and Shrubland) based upon what we learn from these two biomes. This project will also contribute to critically needed Earth system science data such as in situ ice, mosquito, and vegetation phenology measurements for ground validations of remotely sensed data, which are essential for regional climate change impact assessments. Additionally it will contribute environmental data critical to prevention and management of diseases such as malaria in Asian, African, and other countries. Furthermore, this project will enable students to participate in the International Polar Year (IPY) (2007-2009) through field campaigns conducted by students in polar regions, and web chats between IPY scientists and GLOBE students from all eight GLCs that include non-polar countries.

Polar Contests for the IPY: a Youth Steering Committee Project

NASA Astrophysics Data System (ADS)

Raymond, M.; Senger, K.; Haase, D.; Kaiser, B.; Gonsior, M.; Salmon, R.

2006-12-01

The Polar Contests are a project being initiated by the International Youth Steering Committee (YSC) for the International Polar Year. Two aims integral to the YSC are firstly the networking of young polar researchers across disciplines early in their careers to enable collaboration, and secondly for this network to be involved in outreach to other youth. To meet these two aims with a project coordinated by youth for youth, the YSC will be running Polar Contests pioneered by the New Zealand committee. These contests will run in high schools during 2007, aiming to encourage young people to learn about polar research and express their views on the Polar Regions in as creative of a way as possible. A network of young polar researchers is being formed, and is supported by a website facilitating communication and alliance within this group. This network is also producing teaching resources reflecting the research and polar experiences of its members. These will be compiled into packs and distributed to high schools to inspire youth to produce entries for a Youth Polar Exhibition to tour museums during IPY. Entries will take a wide variety of forms, from artworks to research posters to equipment designs, reflecting the diversity of research and art connected to the poles. The entries to the New Zealand Polar Contests will be exhibited at the International Youth Conference on the Poles, May 2008. Although currently a New Zealand project, we anticipate that the Polar Contests will provide a useful model to be adopted by other countries involved in IPY.

Atmospheric Mercury Transport and Chemistry in Western Canada and the Arctic: Results from the IPY Project INCATPA

NASA Astrophysics Data System (ADS)

Cole, A. S.; Steffen, A.; Hung, H.

2010-12-01

Elevated levels of mercury and other pollutants are an ongoing threat to the health of Arctic people and wildlife, despite the vast distance that separates the region from major anthropogenic sources of these contaminants. The International Polar Year (IPY) project INterContinental Atmospheric Transport of anthropogenic Pollutants to the Arctic (INCATPA) is investigating the transport of pollutants, specifically persistent organic pollutants and mercury, from source regions to the remote Arctic. Transport from Asia is of particular interest since Asian sources comprise a significant and increasing fraction of global mercury emissions. The INCATPA project is also studying how climate change may affect atmospheric chemistry and transport of these pollutants in the Arctic. Mercury studies under INCATPA have involved concurrent measurements of ambient mercury during the period 2007-2009 at new and ongoing sites in Arctic and Pan-Pacific regions. These data include a first look at ambient mercury levels in areas of western Canada where mercury had not previously been monitored. At some sites, mercury measurements were analyzed along with supplementary data to assess contributions from local and long-distance sources. Long-term Arctic monitoring data were also used to address how climate change may already be affecting mercury chemistry and deposition in this region. As IPY and the INCATPA project wind down, their legacy is a continuation of mercury monitoring at these sites and new international scientific relationships to support growing international cooperation on the delivery of sound science for the development of public policy on mercury.

Chronic lymphocytic leukemia: A prognostic model comprising only two biomarkers (IGHV mutational status and FISH cytogenetics) separates patients with different outcome and simplifies the CLL-IPI.

PubMed

Delgado, Julio; Doubek, Michael; Baumann, Tycho; Kotaskova, Jana; Molica, Stefano; Mozas, Pablo; Rivas-Delgado, Alfredo; Morabito, Fortunato; Pospisilova, Sarka; Montserrat, Emili

2017-04-01

Rai and Binet staging systems are important to predict the outcome of patients with chronic lymphocytic leukemia (CLL) but do not reflect the biologic diversity of the disease nor predict response to therapy, which ultimately shape patients' outcome. We devised a biomarkers-only CLL prognostic system based on the two most important prognostic parameters in CLL (i.e., IGHV mutational status and fluorescence in situ hybridization [FISH] cytogenetics), separating three different risk groups: (1) low-risk (mutated IGHV + no adverse FISH cytogenetics [del(17p), del(11q)]); (2) intermediate-risk (either unmutated IGHV or adverse FISH cytogenetics) and (3) high-risk (unmutated IGHV + adverse FISH cytogenetics). In 524 unselected subjects with CLL, the 10-year overall survival was 82% (95% CI 76%-88%), 52% (45%-62%), and 27% (17%-42%) for the low-, intermediate-, and high-risk groups, respectively. Patients with low-risk comprised around 50% of the series and had a life expectancy comparable to the general population. The prognostic model was fully validated in two independent cohorts, including 417 patients representative of general CLL population and 337 patients with Binet stage A CLL. The model had a similar discriminatory value as the CLL-IPI. Moreover, it applied to all patients with CLL independently of age, and separated patients with different risk within Rai or Binet clinical stages. The biomarkers-only CLL prognostic system presented here simplifies the CLL-IPI and could be useful in daily practice and to stratify patients in clinical trials. © 2017 Wiley Periodicals, Inc.

Integrating Research, Education, Outreach and Communication Through Storytelling: A Case Study in Progress

NASA Astrophysics Data System (ADS)

McCaffrey, M. S.; Ledley, T.; Manduca, C.; Salmon, R.

2006-12-01

In order to provide a meaningful context for non-technical users to be able to decipher and comprehend research data, it is necessary to provide background into the process involved. Storytelling can provide the narrative description that brings data alive by showing the 'Who' (providing human interest, education and training background, and career opportunities information), 'What' (focusing on discipline, field of study, research questions, and significance), 'Where' (geographic location(s), logistics involved in getting there, and elevation or depth), 'When' (time(s) of day, year data collected, and temporal scale data focus on), 'Why' (why is the data important intellectually as well as in the broader, societal context) and especially the 'How' (what tools, technology, mathematics, and statistics are used to collect, archive, and analyze data). The upcoming International Polar Year (IPY), running from March 2007 to March 2009, builds on prior polar research and IPYs, and offers a unique opportunity to showcase the process of data collection and analysis in a compelling human context. Internationally, the IPY Education, Outreach and Communication (EOC) subcommittee is seeking to integrate the EOC continuum and when appropriate repurpose information about specific research projects. For example, descriptions of projects designed initially for media purposes may also serve as the "at a glance" overview of a project that can then link to more detailed narrative descriptions of the projects, augmented with video and audio clips, web-links to related background information and relevant curriculum, and ultimately to the data itself, well scaffolded with relevant supporting materials and tools. In the United States, plans are underway for developing a suite of data stories that provide the narrative background of a project and can be used in museum kiosks and other informal science settings, data sheets, that provide teachers with an overview of the data, and curriculum and training for teachers using the model developed by the Earth Exploration Toolkit.

High prevalence of Schistosoma mansoni and other intestinal parasites among elementary school children in Southwest Ethiopia: a cross-sectional study.

PubMed

Jejaw, Ayalew; Zemene, Endalew; Alemu, Yayehirad; Mengistie, Zemenu

2015-07-02

Intestinal parasitic infections (IPIs) pose significant public health challenges in school children in developing countries. The aim of this study is to determine prevalence of intestinal parasites among elementary school children in Mizan-Aman town, southwest Ethiopia. Institution-based cross-sectional study involving 460 elementary school children in Mizan-Aman Town was conducted from May to June 2013. The school children were selected using multistage sampling technique. Data on demography and predisposing factors of IPIs were collected using pretested questionnaire. Moreover, single stool specimen was examined microscopically after wet mount and formol-ether sedimentation concentration procedures. Infection intensity of Schistosoma mansoni and soil-transmitted helminths (STHs) was estimated using Kato-Katz egg counting method. Age of the children ranged from 5 to 17 years. Overall, 76.7% (95%CI: 72.8-80.6) of the children harbored at least one species of intestinal parasite. Eight species of intestinal parasites were detected with S. mansoni (44.8%) and Ascaris lumbricoides (28.7%) being predominant. Helminths and pathogenic intestinal protozoa were detected in 73.9 and 7.8% of the children, respectively. After adjusting for other variables, age between 5 and 9 years (AOR, 2.6, 95%CI, 1.552-4.298), male gender (AOR, 2.1, 95%CI, 1.222-3.526), attending public school (AOR, 0.1, 95%CI, 0.060-0.256), using river/well water (AOR, 2.4, 95%CI, 0.912-6.191), irregular washing of hands before meal (AOR, 0.5, 95%CI, 0.254-0.865), consuming street food (AOR, 2.3, 95%CI, 1.341-3.813) and raw vegetables (AOR, 2.7, 95%CI, 1.594-4.540) were significantly associated with IPIs in the study participants. Prevalence of intestinal parasites among the school children was high. Deworming of the school children and continuous follow up is required.

APECS: A Model Organization for Bridging Past to Present and Developing a New Generation of Polar Scientists (Invited)

NASA Astrophysics Data System (ADS)

Timm, K.; Baeseman, J. L.; Membership, Association Of Polar Early Career Scientists

2010-12-01

One of the greatest legacies of the International Polar Year (IPY) is the creation of APECS, the Association of Polar Early Career Scientists. As a grassroots effort, APECS was proposed, formed, and developed by and for early career polar researchers. While the young investigators who founded APECS had talent, ambition, and the desire to make things happen, partnerships with key organizations and experienced leaders in polar science were essential to provide the funding, leadership, and mentorship that has taken the organization well beyond the IPY and to over 2000 members. In four years, APECS has strived to foster the skills of and develop a group of early career interdisciplinary polar scientists through networking and mentoring among themselves and with senior scientists. Through diverse activities including, panel discussions, career development workshops, online seminars, a comprehensive job listing, formal mentoring, meeting travel support, and the APECS Virtual Poster Session, APECS goal is to support the early career researcher being trained to do the science, to become a well-rounded scientist prepared for 21st century careers in science. As part of that training, APECS members are encouraged to participate in activities and training related to science communication, education, and outreach; working with the media; participating in the science / public policy interface; and working with arctic communities and indigenous peoples. During the IPY, APECS members were guest speakers and presenters on International Polar Day activities; they contributed to resources for education and outreach such as the book: Polar Science and Global Climate: An International Resource for Education and Outreach; and they made connections with educators, community groups, the media through in-person presentations, blogs from the field, videos, and much more. Workshops, panels, and online discussions focusing on these activities helped develop the capacity to conduct such activities—which are often not part of a traditional science graduate program of study. APECS is proof that a community driven effort can become a robust professional organization in just a few short years. Working with senior scientists and other mentors, such as non-science faculty members, educators, members of the media, administrative professionals, and policy makers, to build capacity of the membership and the organization is a major lesson from the establishment of APECS. Additional lessons include, nurturing your volunteers and new ideas. By building connections between senior scientists, and established polar science organizations to new scientists and professionals and fresh ideas APECS is creating a continuum by which polar science can effectively transition from observation, to synthesis, and towards response. In a period where the polar regions are experiencing rapid environmental change, having the tools and skills to work effectively cross-discipline and within, as well as outside the scientific community, will be essential to address the changes through science-based policy and a well-informed public. APECS can serve as a model for other early career initiatives in many disciplines and countries.

High pressure common rail injection system modeling and control.

PubMed

Wang, H P; Zheng, D; Tian, Y

2016-07-01

In this paper modeling and common-rail pressure control of high pressure common rail injection system (HPCRIS) is presented. The proposed mathematical model of high pressure common rail injection system which contains three sub-systems: high pressure pump sub-model, common rail sub-model and injector sub-model is a relative complicated nonlinear system. The mathematical model is validated by the software Matlab and a virtual detailed simulation environment. For the considered HPCRIS, an effective model free controller which is called Extended State Observer - based intelligent Proportional Integral (ESO-based iPI) controller is designed. And this proposed method is composed mainly of the referred ESO observer, and a time delay estimation based iPI controller. Finally, to demonstrate the performances of the proposed controller, the proposed ESO-based iPI controller is compared with a conventional PID controller and ADRC. Copyright © 2016 ISA. Published by Elsevier Ltd. All rights reserved.

Association between interpregnancy interval and the risk of recurrent loss after a midtrimester loss.

PubMed

Roberts, C L; Algert, C S; Ford, J B; Nippita, T A; Morris, J M

2016-12-01

After an initial midtrimester loss, is the interval to the next conception associated with the risk of a recurrent loss? Among women who had a pregnancy loss at 14-19 weeks gestation, conception at least 3 months after this initial loss was associated with a reduced risk of a recurrent loss. A short interpregnancy interval (IPI) has been thought to increase risk but recent studies of pregnancy after a loss have found no effect; however, these studies have been based almost entirely on an initial first trimester (<14 weeks) loss. A retrospective cohort study drawing on over 997 000 linked birth and hospital records from New South Wales, Australia for 2003-2011. Index pregnancies were those of women who had a first recorded pregnancy loss of 14-23 weeks gestation (miscarriage, termination and perinatal death). The study population was 4290 women who conceived again within 2 years. The index loss was categorized by subgroups: 14-19 weeks gestation versus 20-23 weeks, and by whether spontaneous or a termination. The primary outcome was any loss or perinatal death before 24 weeks in the subsequent pregnancy. After a 14-19 weeks index loss, an IPI of ≤3 months had an increased rate of recurrent loss compared with an IPI of >9-12 months: 21.9% versus 11.3% (adjusted relative risk (aRR) = 2.02, 95% CI 1.44-2.83). For women who had a spontaneous index loss of 20-23 weeks, there was no evidence that a short IPI increased or decreased the risk of recurrent loss. For any gestational age group of index losses, an IPI of >18-24 months increased the risk of a recurrent loss; the risk was highest after a 20-23 weeks index loss (aRR = 2.15, 95% CI 1.18-3.91). We do not know how many cycles were required to achieve conception. Pregnancies resulting in early first trimester losses are unlikely to have resulted in hospitalization so would not have been identified. The risk of recurrent loss after an initial midtrimester loss may differ from the risk after an initial first trimester loss. This work was supported by an Australian National Health and Medical Research Council (NHMRC) Centre for Research Excellence Grant (1001066). C.L.R. is supported by an NHMRC Senior Research Fellowship (#APP1021025). J.B.F. is supported by an ARC Future Fellowship (#120100069). The authors have no conflicts of interest to declare. N/A. © The Author 2016. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Risk factors for work-related injury among farm workers: a 1-year study.

PubMed

Molineri, A; Signorini, M L; Tarabla, H D

2015-01-01

A 1-year prospective study was carried out to look for risk factors of farm-related injuries in Egusquiza, Santa Fe (Argentina). Information on demographic characteristics and occupational accidents was collected on (N=110, n=78) farm workers by means of personal interviews using a structured questionnaire. Monthly telephone contact was then maintained with the workers for 1 year to document all farm-related injuries. Data analysis included incidence rate, χ2 and logistic regression. Sixty-nine farm-related injuries were reported during the study period, six injuries being the maximum number affecting one worker. A total of 46.3% of the workers suffered at least one injury during the year. The incidence rate was 7.5 injuries/100 individual-month at risk. Medical assistance was needed in 26.8% of the cases and 5.8% of the injuries caused at least 1 day off work. Hospitalization for at least 1 day was required for 2.9% of the injured workers. Previous work-related injury in the family (p=0.005) (odds ratio (OR)=4.6, 95% confidence interval (CI)=1.6-13.3) and worker's activity (p=0.021) (OR=3.7, 95%CI=1.2-11.6) were associated with the dependent variable work injury. Agricultural and livestock farming are of great importance for the national economy. Workers' training on farm safety may play a key role to prevent work-related injuries and diseases.

DHHC3 Contributions to Breast Cancer

DTIC Science & Technology

2014-11-01

oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.021 0.572 IPI00015954 GTP-binding protein SAR1a SAR1A 0.546 0.573 IPI00011937 Peroxiredoxin-4 PRDX4...previous report that DHHC3 itself is an integral membrane protein (10). In addition, the most significant biological processes regulated by DHHC3 are cell...motion and vesicle-mediated transport (Fig. 8), two processes important for cancer cell invasion and metastasis. Figure 7. Gene ontology

Evaluation of an intravenous preparation information system for improving the reconstitution and dilution process.

PubMed

Jo, Yun Hee; Shin, Wan Gyoon; Lee, Ju-Yeun; Yang, Bo Ram; Yu, Yun Mi; Jung, Sun Hoi; Kim, Hyang Sook

2016-10-01

There are very few studies reporting the impact of providing intravenous (IV) preparation information on quality use of antimicrobials, particularly regarding their reconstitution and dilution. Therefore, to improve these processes in IV antimicrobial administration, an IV preparation information system (IPIS) was implemented in a hospital. We aimed to evaluate the effect of improving reconstitution and dilution by implementing an IPIS in the electronic medical record (EMR) system. Prescriptions and activity records of nurses for injectable antimicrobials that required reconstitution and dilution for IV preparation from January 2008 to December 2013 were retrieved from EMR, and assessed based on packaging label information for reconstituting and diluting solutions. We defined proper reconstitution and dilution as occurring when the reconstitution and dilution solutions prescribed were consistent with the nurses' acting records. The types of intervention in the IPIS were as follows: a pop-up alert for proper reconstitution and passive guidance for proper dilution. We calculated the monthly proper reconstitution rate (PRR) and proper dilution rate (PDR) and evaluated the changes in these rates and trends using interrupted time series analyses. Prior to the initiation of the reconstitution alert and dilution information, the PRR and PDR were 12.7 and 46.1%, respectively. The reconstitution alert of the IPIS rapidly increased the PRR by 41% (p<0.001), after which the PRR decreased by 0.9% (p=0.013) per month after several months. However, there was no significant change in the rate or trend of the PDR during the study period. This study demonstrated that the provision of reconstitution alerts by the IPIS contributed to improving the reconstitution process of IV antimicrobial injection administration. However, providing passive information on dilution solutions was ineffective. Furthermore, solutions to ensure the continuous effectiveness of alert systems are warranted and should be actively sought. Copyright © 2016. Published by Elsevier Ireland Ltd.

New York City International Polar Weekend at the American Museum of Natural History

NASA Astrophysics Data System (ADS)

Pfirman, S.; Turrin, M.; Macphee, R.

2008-12-01

The American Museum of Natural History, in partnership with Lamont-Doherty Earth Observatory and the Earth Institute of Columbia University and Barnard College, is featuring the International Polar Year through a New York City International Polar Weekend (NYC-IPW) in 2007, 2008 and 2009. The event showcases current polar research, polar environmental changes, history and culture during two days of family programs and activities, performances, and lectures. The goal of the NYC-IPW is to engage diverse audiences and enhance the public understanding of polar science, in particular IPY research, through close interactions with polar experts. Activities for the public include many disciplines, ranging from the physical sciences and cultural anthropology to music and art, and are presented in many forms, from lectures, panels and films to posters and play. Highlights of the NYC-IPW include: 1) A polar fair for youth and adults, showcasing scientists, artists, and educators who have worked at one or both poles and including many interactive exhibits featuring such topics as life in New York at the end of the last Ice Age, how Arctic sea ice is changing, and life on and under the ice. 2) Performances and presentations oriented towards children and families, including Inuit Throat Singers, Central Park Zoo Theater Group, and a northern lights show. 3) Lectures showcasing current IPY research and addressing such issues as the possible effects of climate change on the poles and the rest of the world, as well as polar poetry, art and film. 4) A partnership with New York City Urban Advantage program for Middle School students in the city to meet with scientists, teachers and students who had participated in polar research and travel. 5) Norwegian Consulate sponsorship of science presenters and Sami performers. The March 2007 event involved 85 presenters and volunteers from 22 institutions, and attracted ca. 3,500 visitors. Approximately 5,000 visitors attended the February 2008 event with 95 presenters and volunteers from 24 institutions. Visitors surveyed appreciated interacting with polar experts, gaining a new understanding of changing polar environments, and connecting science with art and culture. The NYC-IPW is a new and unique partnership between with the research community and public programming at AMNH that successfully engages the public in learning about the poles.

Frontier Science in the Polar Regions: Current Activities of the Polar Research Board

NASA Astrophysics Data System (ADS)

Brown, L. M.

2011-12-01

The National Academies (the umbrella term for the National Academy of Sciences, National Academy of Engineering, Institute of Medicine, and National Research Council) is a private, nonprofit organization chartered by Congress in 1863. The Polar Research Board (PRB) is the focal point within the Academies for providing advice on issues related to the Arctic, Antarctic, and cold regions in general. Tasks within the PRB mission include: providing a forum for the polar science community to address research needs and policy issues; conducting studies and workshops on emerging scientific and policy issues in response to requests from federal agencies and others; providing program reviews, guidance, and assessments of priorities; and facilitating communication on polar issues among academia, industry, and government. The PRB also serves as the US National Committee to two international, nongovernmental polar science organizations: the Scientific Committee on Antarctic Research (SCAR) and the International Arctic Science Committee (IASC). The polar regions are experiencing rapid changes in environment and climate, and the PRB has a number of completed and ongoing studies that will enhance scientific understanding of these issues. This poster will illustrate current PRB activities as well as results from two recently released reports: Frontiers in Understanding Climate Change and Polar Ecosystems and Future Science Opportunities in Antarctica and the Southern Ocean. In the former, a set of frontier research questions are developed to help scientists understand the impacts of climate change on polar ecosystems. The report builds on existing knowledge of climate change impacts and highlights the next big topics to be addressed in the coming decades. In addition, a number of methods and technologies are identified that will be useful to advance future research in polar ecosystem science. In the latter, changes to important science conducted on Antarctica and the surrounding Southern Ocean will be summarized. The report will identify the anticipated types and scope of US scientific programs in the region over the next two decades. It will also examine opportunities for international Antarctic scientific collaborations and report any new and emerging technologies. Through these reports, ongoing studies and workshops, and various outreach methods, the PRB plays an important role in dissemination of polar science, both in the United States and internationally. For example, the PRB played a critical role in planning the International Polar Year (IPY) 2007-2008 and is currently conducting a synthesis study called Legacies and Lessons of IPY 2007-2008. The report will be informed by a large community workshop and will examine what was learned and how the many pieces of IPY combine to move polar understanding forward in the future. Other PRB reports (e.g., Scientific Value of Arctic Sea Ice Imagery Derived Products and Toward an Integrated Arctic Observing Network) have also had important implications for current and future polar research.

Additive Manufacturing: Preparing for the Reality of Science Fiction

DTIC Science & Technology

2015-09-01

3, 2007, http://ipi.org/ipi_issues/detail/the- true-cost-of-copyright-industry-piracy-to-the-us-economy. 21 are Bitcoin , the crypto-currency, and... Bitcoin is the New Napster….And That Is a Good Thing,” The Casey Report, August 28, 2013, https://www.caseyresearch.com/articles/ bitcoin -is-the-new...chiefs- issue-recommendations-drones-look-how-they-measure. Steinhart, Dan. “ Bitcoin is the New Napster…And That Is a Good Thing.” The Casey Report

Increased body mass index is associated with improved overall survival in extranodal natural killer/T-cell lymphoma, nasal type.

PubMed

Li, Ya-Jun; Yi, Ping-Yong; Li, Ji-Wei; Liu, Xian-Ling; Liu, Xi-Yu; Zhou, Fang; OuYang, Zhou; Sun, Zhong-Yi; Huang, Li-Jun; He, Jun-Qiao; Yao, Yuan; Fan, Zhou; Tang, Tian; Jiang, Wen-Qi

2017-01-17

The role of body mass index (BMI) in lymphoma survival outcomes is controversial. The prognostic significance of BMI in extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is unclear. We evaluated the prognostic role of BMI in patients with ENKTL. We retrospectively analyzed 742 patients with newly diagnosed ENKTL. The prognostic value of BMI was compared between patients with low BMIs (< 20.0 kg/m2) and patients with high BMIs (≥ 20.0 kg/m2). The prognostic value of the International Prognostic Index (IPI) and the Korean Prognostic Index (KPI) was also evaluated and compared with that of the BMI classification. Patients with low BMIs tended to exhibit higher Eastern Cooperative Oncology Group performance status (ECOG PS) scores (≥ 2) (P = 0.001), more frequent B symptoms (P < 0.001), lower albumin levels (P < 0.001), higher KPI scores (P = 0.03), and lower rates of complete remission (P < 0.001) than patients with high BMIs, as well as inferior progression-free survival (PFS, P = 0.003), and inferior overall survival (OS, P = 0.001). Multivariate analysis demonstrated that age > 60 years, mass > 5 cm, stage III/IV, elevated LDH levels, albumin levels < 35 g/L and low BMIs were independent adverse predictors of OS. The BMI classification was found to be superior to the IPI with respect to predicting patient outcomes among low-risk patients and the KPI with respect to distinguishing between intermediate-low- and high-intermediate-risk patients. Higher BMI at the time of diagnosis is associated with improved overall survival in ENKTL. Using the BMI classification may improve the IPI and KPI prognostic models.

Increased body mass index is associated with improved overall survival in extranodal natural killer/T-cell lymphoma, nasal type

PubMed Central

Li, Ya-Jun; Yi, Ping-Yong; Li, Ji-Wei; Liu, Xian-Ling; Liu, Xi-Yu; Zhou, Fang; OuYang, Zhou; Sun, Zhong-Yi; Huang, Li-Jun; He, Jun-Qiao; Yao, Yuan; Fan, Zhou; Tang, Tian; Jiang, Wen-Qi

2017-01-01

Objectives: The role of body mass index (BMI) in lymphoma survival outcomes is controversial. The prognostic significance of BMI in extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is unclear. We evaluated the prognostic role of BMI in patients with ENKTL. Methods: We retrospectively analyzed 742 patients with newly diagnosed ENKTL. The prognostic value of BMI was compared between patients with low BMIs (< 20.0 kg/m2) and patients with high BMIs (≥ 20.0 kg/m2). The prognostic value of the International Prognostic Index (IPI) and the Korean Prognostic Index (KPI) was also evaluated and compared with that of the BMI classification. Results: Patients with low BMIs tended to exhibit higher Eastern Cooperative Oncology Group performance status (ECOG PS) scores (≥ 2) (P = 0.001), more frequent B symptoms (P < 0.001), lower albumin levels (P < 0.001), higher KPI scores (P = 0.03), and lower rates of complete remission (P < 0.001) than patients with high BMIs, as well as inferior progression-free survival (PFS, P = 0.003), and inferior overall survival (OS, P = 0.001). Multivariate analysis demonstrated that age > 60 years, mass > 5 cm, stage III/IV, elevated LDH levels, albumin levels < 35 g/L and low BMIs were independent adverse predictors of OS. The BMI classification was found to be superior to the IPI with respect to predicting patient outcomes among low-risk patients and the KPI with respect to distinguishing between intermediate-low- and high-intermediate-risk patients. Conclusions: Higher BMI at the time of diagnosis is associated with improved overall survival in ENKTL. Using the BMI classification may improve the IPI and KPI prognostic models. PMID:28002803

Prognostic role of ABO blood type in patients with extranodal natural killer/T cell lymphoma, nasal type: a triple-center study.

PubMed

Li, Ya-Jun; Yi, Ping-Yong; Li, Ji-Wei; Liu, Xian-Ling; Tang, Tian; Zhang, Pei-Ying; Jiang, Wen-Qi

2017-07-31

The prognostic significance of ABO blood type for lymphoma is largely unknown. We evaluated the prognostic role of ABO blood type in patients with extranodal natural killer (NK)/T-cell lymphoma (ENKTL). We retrospectively analyzed clinical data of 697 patients with newly diagnosed ENKTL from three cancer centers. The prognostic value of ABO blood type was evaluated using Kaplan-Meier curves and Cox proportional hazard models. The prognostic values of the International Prognostic Index (IPI) and the Korean Prognostic Index (KPI) were also evaluated. Compared with patients with blood type O, those with blood type non-O tended to display elevated baseline serum C-reactive protein levels (P = 0.038), lower rate of complete remission (P = 0.005), shorter progression-free survival (PFS, P < 0.001), and shorter overall survival (OS, P = 0.001). Patients with blood type O/AB had longer PFS (P < 0.001) and OS (P = 0.001) compared with those with blood type A/B. Multivariate analysis demonstrated that age >60 years (P < 0.001), mass ≥5 cm (P = 0.001), stage III/IV (P < 0.001), elevated serum lactate dehydrogenase (LDH) levels (P = 0.001), and blood type non-O were independent adverse predictors of OS (P = 0.001). ABO blood type was found to be superior to both the IPI in discriminating patients with different outcomes in the IPI low-risk group and the KPI in distinguishing between the intermediate-to-low- and high-to-intermediate-risk groups. ABO blood type was an independent predictor of clinical outcome for patients with ENKTL.

Localized primary gastrointestinal diffuse large B cell lymphoma received a surgical approach: an analysis of prognostic factors and comparison of staging systems in 101 patients from a single institution.

PubMed

Zhang, Shengting; Wang, Li; Yu, Dong; Shen, Yang; Cheng, Shu; Zhang, Li; Qian, Ying; Shen, Zhixiang; Li, Qinyu; Zhao, Weili

2015-08-15

Diffuse large B cell lymphoma (DLBCL) represents the most common histological subtype of primary gastrointestinal lymphoma and is a heterogeneous group of disease. Prognostic characterization of individual patients is an essential prerequisite for a proper risk-based therapeutic choice. Clinical and pathological prognostic factors were identified, and predictive value of four previously described prognostic systems were assessed in 101 primary gastrointestinal DLBCL (PG-DLBCL) patients with localized disease, including Ann Arbor staging with Musshoff modification, International Prognostic Index (IPI), Lugano classification, and Paris staging system. Univariate factors correlated with inferior survival time were clinical parameters [age>60 years old, multiple extranodal/gastrointestinal involvement, elevated serum lactate dehydrogenase and β2-microglobulin, and decreased serum albumin], as well as pathological parameters (invasion depth beyond serosa, involvement of regional lymph node or adjacent tissue, Ki-67 index, and Bcl-2 expression). Major independent variables of adverse outcome indicated by multivariate analysis were multiple gastrointestinal involvement. In patients unfit for Rituximab but received surgery, radical surgery significantly prolonged the survival time, comparing with alleviative surgery. Addition of Rituximab could overcome the negative prognostic effect of alleviative surgery. Among the four prognostic systems, IPI and Lugano classification clearly separated patients into different risk groups. IPI was able to further stratify the early-stage patients of Lugano classification into groups with distinct prognosis. Radical surgery might be proposed for the patients unfit for Rituximab treatment, and a combination of clinical and pathological staging systems was more helpful to predict the disease outcome of PG-DLBCL patients.

Socioenvironmental conditions and intestinal parasitic infections in Brazilian urban slums: a cross-sectional study

PubMed Central

Ignacio, Caroline Ferraz; da Silva, Milena Enderson Chagas; Handam, Natasha Berendonk; Alencar, Maria de Fatima Leal; Sotero-Martins, Adriana; Barata, Martha Macedo de Lima; de Moraes, Antonio Henrique Almeida

2017-01-01

ABSTRACT Intestinal parasitic infections (IPIs) are neglected diseases with limited data regarding prevalence in Brazil and many other countries. In increasingly urban societies, investigating the profile and socioenvironmental determinants of IPIs in the general population of slum dwellers is necessary for establishing appropriate public policies catered to these environments. This study assessed the socioenvironmental conditions and prevalence of IPIs in slums of Rio de Janeiro, RJ State, Brazil. Methods A cross-sectional study covering an agglomeration of urban slums was conducted between 2015 and 2016 using participants observation, a socioeconomic survey, and the spontaneous sedimentation method with three slides per sample to analyze fresh stool specimens ( n =595) searching for intestinal parasites. Results Endolimax nana ( n =95, 16.0%) and Entamoeba coli ( n =65, 10.9%) were the most frequently identified agents, followed by Giardia intestinalis ( n =24, 4.0%) and Ascaris lumbricoides ( n =11, 1.8%). Coinfections caused by E. nana and E. histolytica/dispar and by Entamoeba coli/A. lumbricoides were significant. The use of piped water as drinking water, the presence of A. lumbricoides , and contamination with coliform bacteria and Escherichia coli were more common in major area (MA) 1. Children (0-19 years) had a greater chance of living in poverty (OR 3.36; 95% CI: 2.50- 4.52; p <0.001) which was pervasive. The predominance of protozoa parasites suggests that a one-size-fits-all approach focusing on preventive chemotherapy for soil-transmitted helminths is not appropriate for all communities in developing countries. It is important that both residents and health professionals consider the socioenvironmental conditions of urban slums when assessing intestinal parasitic infections for disease control and health promotion initiatives. PMID:28793024

National Oceanic and Atmospheric Administration(NOAA) Arctic Climate Change Studies: A Contribution to IPY

NASA Astrophysics Data System (ADS)

Calder, J.; Overland, J.; Uttal, T.; Richter-Menge, J.; Rigor, I.; Crane, K.

2004-12-01

NOAA has initiated four activities that respond to the Arctic Climate Impact Assessment(ACIA) recommendations and represent contributions toward the IPY: 1) Arctic cloud, radiation and aerosol observatories, 2) documentation and attribution of changes in sea-ice thickness through direct measurement and modeling, 3) deriving added value from existing multivariate and historical data, and 4) following physical and biological changes in the northern Bering and Chukchi Seas. Northeast Canada, the central Arctic coast of Russia and the continuing site at Barrow have been chosen as desirable radiation/cloud locations as they exhibit different responses to Arctic Oscillation variability. NOAA is closely collaborating with Canadian groups to establish an observatory at Eureka. NOAA has begun deployment of a network of ice-tethered ice mass balance buoys complemented by several ice profiling sonars. In combination with other sea ice investigators, the Arctic buoy program, and satellites, changes can be monitored more effectively in sea ice throughout the Arctic. Retrospective data analyses includes analysis of Arctic clouds and radiation from surface and satellite measurements, correction of systematic errors in TOVS radiance data sets for the Arctic which began in 1979, addressing the feasibility of an Arctic System Reanalysis, and an Arctic Change Detection project that incorporates historical and recent physical and biological observations and news items at a website, www.arctic.noaa.gov. NOAA has begun a long-term effort to detect change in ecosystem indicators in the northern Bering and Chukchi Seas that could provide a model for other northern marine ecosystems. The first efforts were undertaken in summer 2004 during a joint Russian-US cruise that mapped the regions physical, chemical and biological parameters to set the stage for future operations over the longer term. A line of biophysical moorings provide detection of the expected warming of this area. A retrospective analysis is also underway. NOAA is open to partnerships as the IPY develops.

Permafrost Young Researchers Get Their Hands Dirty: The PYRN-Thermal State of Permafrost IPY Project

NASA Astrophysics Data System (ADS)

Johansson, M.; Lantuit, H.

2009-04-01

The Permafrost Young Researchers Network (PYRN) (www.pyrn.org) is a unique resource for students and young scientists and engineers studying permafrost. It is an international organization fostering innovative collaboration, seeking to recruit, retain, and promote future generations of permafrost scientists and engineers. Initiated for and during IPY, PYRN directs the multi-disciplinary talents of its membership toward global awareness, knowledge, and response to permafrost-related challenges in a changing climate. Created as an education and outreach component of the International Permafrost Association (IPA), PYRN is a central database of permafrost information and science for more than 500 young researchers from over 40 countries. PYRN distributes a newsletter, recognizes outstanding permafrost research by its members through an annual awards program, organizes training workshops (2007 in Abisko, Sweden and St. Petersburg, Russia, 2008 in Fairbanks, Alaska and St. Petersburg, Russia), and contributes to the growth and future of the permafrost community. While networking forms the basis of PYRN's activities, the organization also seeks to establish itself as a driver of permafrost research for the IPY and beyond. We recently launched a series of initiatives on several continents aimed at providing young scientists and engineers with the means to conduct ground temperature monitoring in under investigated permafrost regions. Focusing on sites not currently covered by the IPA's "Thermal State of Permafrost" project, the young investigators of PYRN successfully launched and funded the PYRN-TSP project. They use lightweight drills and temperature sensors to instrument shallow boreholes in those regions. The first phase of the project was started in the spring of 2008 at Scandinavian sites. The data and results will be incorporated in the global database on permafrost temperatures and made freely available to the scientific community, thereby contributing to the advance of permafrost science and the strengthening of the next generation of permafrost researchers.

Intestinal parasitic infections in different groups of immunocompromised patients in Kashan and Qom cities, central Iran.

PubMed

Rasti, Sima; Hassanzadeh, Malihe; Hooshyar, Hossein; Momen-Heravi, Mansooreh; Mousavi, Seyed Gholam Abbas; Abdoli, Amir

Intestinal parasitic infections (IPIs) are important causes of morbidity and mortality in patients with immunocompromising conditions. The aim of this study was to determine the prevalence of IPIs in different groups of immunocompromised patients, including hemodialysis patients (HD), renal transplant recipients (RTR), cancer and HIV/AIDS patients in comparison with healthy individuals in two central cities of Iran (Kashan and Qom). In this case-control study, the stool samples of 135 HD, 50 RTR, 60 cancer patients, 20 HIV/AIDS patients and 120 healthy subjects were tested using direct-smear, formol-ether concentration, Ziehl-Neelsen staining and Agar plate method. The overall infection rate was 11.7% (31/265) in patient groups and 0% (0/120) in the control group. The frequency of parasites was 25% in HIV/AIDS patients, 11.9% (16/135) in HD, 12.0% (6/50) in RTR and 6.7% (4/60) in cancer patients. Blastocystis hominis (4.2%) and Giardia lamblia (3.0%) were the most prevalent parasites in patient groups. The infection rate was significantly higher in male (17.6%) than female (5.4%) patients (p = .002), but no statistically significant association was observed according to the age and educational levels. This study showed a high prevalence of IPIs in immunocompromised patients. The results of this study suggest that periodic stool examinations for screening of IPIs should be included as a part of routine medical care in these patients.

Prevention and treatment of Encephalitozoon cuniculi infection in immunosuppressed rabbits with fenbendazole

PubMed Central

Abu-Akkada, S. S.; Oda, S. S.

2016-01-01

This study was conducted to evaluate the efficacy of oral administration of fenbendazole (20 mg/kg body weight) prior to and after experimental infection of immunosuppressed rabbits with Encephalitozoon cuniculi. A total of thirty rabbits were divided into five groups: NN (non-immunosuppressed; non-infected), IN (immunosuppressed; non-infected), IPI (immunosuppressed; protected-infected), ITI (immunosuppressed; treated-infected), and II (immunosuppressed; infected) groups. Fenbendazole was administered as a prophylactic for seven successive days before infection with E. cuniculi and as a treatment for four weeks initiated on the 28th day post-challenge (PC). Experimental rabbits were infected with intraperitoneal injection of 2 × 105 E. cuniculi spores. Parameters evaluated were body weight, detection of spores in urine, serum antibody assay, hematological, biochemical and histopathological changes. The IPI and ITI groups showed a significant better final bwt than the II group. Spores were detected in urine of all infected rabbits from the 28th day PC until the end of the study. The IPI group showed the least values of antibodies (IgG) compared to the ITI and II groups. Concerning histopathological changes, the intensity of the lesions was marked particularly in the II rabbits and to a lesser extent in the ITI rabbits. Noticeable improvement was found in the IPI rabbits. It could be concluded that fenbendazole was effective to some extent in protection of rabbits against E. cuniculi infection, while when administered as a therapeutic no significant effects were observed. PMID:27822234

Prevention and treatment of Encephalitozoon cuniculi infection in immunosuppressed rabbits with fenbendazole.

PubMed

Abu-Akkada, S S; Oda, S S

2016-01-01

This study was conducted to evaluate the efficacy of oral administration of fenbendazole (20 mg/kg body weight) prior to and after experimental infection of immunosuppressed rabbits with Encephalitozoon cuniculi . A total of thirty rabbits were divided into five groups: NN (non-immunosuppressed; non-infected), IN (immunosuppressed; non-infected), IPI (immunosuppressed; protected-infected), ITI (immunosuppressed; treated-infected), and II (immunosuppressed; infected) groups. Fenbendazole was administered as a prophylactic for seven successive days before infection with E. cuniculi and as a treatment for four weeks initiated on the 28th day post-challenge (PC). Experimental rabbits were infected with intraperitoneal injection of 2 × 10 5 E. cuniculi spores. Parameters evaluated were body weight, detection of spores in urine, serum antibody assay, hematological, biochemical and histopathological changes. The IPI and ITI groups showed a significant better final bwt than the II group. Spores were detected in urine of all infected rabbits from the 28th day PC until the end of the study. The IPI group showed the least values of antibodies (IgG) compared to the ITI and II groups. Concerning histopathological changes, the intensity of the lesions was marked particularly in the II rabbits and to a lesser extent in the ITI rabbits. Noticeable improvement was found in the IPI rabbits. It could be concluded that fenbendazole was effective to some extent in protection of rabbits against E. cuniculi infection, while when administered as a therapeutic no significant effects were observed.

Role of Immune Microenvironmental Factors for Improving the IPI-related Risk Stratification of Aggressive B Cell Lymphoma.

PubMed

Gong, Yi; Chen, Rui; Zhang, Xi; Zou, Zhong Min; Chen, Xing Hua

2017-07-01

To investigate the risk stratification of aggressive B cell lymphoma using the immune microenvironment and clinical factors. A total of 127 patients with aggressive B cell lymphoma between 2014 and 2015 were enrolled in this study. CD4, Foxp3, CD8, CD68, CD163, PD-1, and PD-L1 expression levels were evaluated in paraffin-embedded lymphoma tissues to identify their roles in the risk stratification. Eleven factors were identified for further evaluation using analysis of variance, chi-square, and multinomial logistic regression analysis. Significant differences in 11 factors (age, Ann Arbor stage, B symptom, ECOG performance status, infiltrating CD8+ T cells, PD-L1 expression, absolute blood monocyte count, serum lactate dehydrogenase, serum iron, serum albumin, and serum β2-microglobulin) were observed among patient groups stratified by at least two risk stratification methods [International Prognostic Index (IPI), revised IPI, and NCCN-IPI models] (P < 0.05). Concordance rates were high (81.4%-100.0%) when these factors were used for the risk stratification. No difference in the risk stratification results was observed with or without the Ann Arbor stage data. We developed a convenient and inexpensive tool for use in risk stratification of aggressive B cell lymphomas, although further studies on the role of immune microenvironmental factors are needed. Copyright © 2017 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.

Get the Power You Need, When and Where You Need It Aboard the International Space Station (ISS) Using the ISS Plug-In Plan (IPiP) Requirement Request Process

NASA Technical Reports Server (NTRS)

Moore, Kevin D.

2017-01-01

Trying to get your experiment aboard ISS? You likely will need power. Many enditem providers do. ISS Plug-In Plan (IPiP) supports power and data for science, Payloads (or Utilization), vehicle systems, and daily operations through the Electrical Power System (EPS) Secondary Power/Data Subsystem. Yet limited resources and increasing requirements continue to influence decisions on deployment of ISS end items. Given the fluid launch schedule and the rapidly- increasing number of end item providers requiring power support, the focus of the Plug-In Plan has evolved from a simple FIFO recommendation to provide power to end item users, to anticipating future requirements by judicious development and delivery of support equipment (cables, power supplies, power strips, and alternating current (AC) power inverters), employing innovative deployment strategies, and collaborating on end item development. This paper describes the evolution of the ISS Program Office, Engineering Directorate, Flight Operations Directorate (FOD), International Partners and the end item provider relationship and how collaboration successfully leverages unique requirements with limited on- board equipment and resources, tools and processes which result in more agile integration, and describes the process designed for the new ISS end item provider to assure that their power requirements will be met.

Knowledge Discovery in our World Information Society: Opportunities for the International Polar Year 2007-08

NASA Astrophysics Data System (ADS)

Berkman, P. A.

2005-12-01

The World Data Center system emerged in 1957-58 with the International Geophysical Year (which was renamed from the 3rd International Polar Year) to preserve and provide access to scientific data collected from observational programs throughout the Earth system. Fast forward a half century ... access to diverse digital information has become effectively infinite and instantaneous with nearly 20,000 petabytes of information produced and stored on print, optical and magnetic media each year; microprocessor speeds that have increased 5 orders of magnitude since 1972; existence of the Internet; increasing global capacity to collect and transmit information via satellites; availability of powerful search engines; and proliferation of data warehouses like the World Data Centers. The problem is that we already have reached the threshold in our world information society when accessing more information does not equate with generating more knowledge. In 2007-08, the International Council of Science and World Meteorological Organization will convene the next International Polar Year to accelerate our understanding of how the polar regions respond to, amplify and drive changes elsewhere in the Earth system (http://www.ipy.org). Beyond Earth system science, strategies and tools for integrating digital information to discover meaningful relationships among the disparate data would have societal benefits from boardrooms to classrooms. In the same sense that human-launched satellites became a strategic focus that justified national investments in the International Geophysical Year, developing the next generation of knowledge discovery tools is an opportunity for the International Polar Year 2007-08 and its affiliated programs to contribute in an area that is critical to the future of our global community. Knowledge is the common wealth of humanity. H.E. Mr. Adama Samassekou President, World Summit on the Information Society

Thermal state of permafrost in North America: A contribution to the international polar year

USGS Publications Warehouse

Smith, S.L.; Romanovsky, V.E.; Lewkowicz, A.G.; Burn, C.R.; Allard, M.; Clow, G.D.; Yoshikawa, K.; Throop, J.

2010-01-01

A snapshot of the thermal state of permafrost in northern North America during the International Polar Year (IPY) was developed using ground temperature data collected from 350 boreholes. More than half these were established during IPY to enhance the network in sparsely monitored regions. The measurement sites span a diverse range of ecoclimatic and geological conditions across the continent and are at various elevations within the Cordillera. The ground temperatures within the discontinuous permafrost zone are generally above -3°C, and range down to -15°C in the continuous zone. Ground temperature envelopes vary according to substrate, with shallow depths of zero annual amplitude for peat and mineral soils, and much greater depths for bedrock. New monitoring sites in the mountains of southern and central Yukon suggest that permafrost may be limited in extent. In concert with regional air temperatures, permafrost has generally been warming across North America for the past several decades, as indicated by measurements from the western Arctic since the 1970s and from parts of eastern Canada since the early 1990s. The rates of ground warming have been variable, but are generally greater north of the treeline. Latent heat effects in the southern discontinuous zone dominate the permafrost thermal regime close to 0°C and allow permafrost to persist under a warming climate. Consequently, the spatial diversity of permafrost thermal conditions is decreasing over time.

Cryosphere Communication from Knowledge to Action: Polar Educators International

NASA Astrophysics Data System (ADS)

Crowley, S.

2012-12-01

Evidence from the recent IPY meetings shows that education and outreach of the 2007-08 IPY touched 24 million people; we intend to grow that number. As a legacy of IPY and as a direct action of IPY Montreal, we announced the establishment of Polar Educators International - a global professional network for those that educate in, for, and about the Polar Regions. We intend to move polar science forward by connecting the cultures and enthusiasm of polar education across the globe. The founding members come from polar and non-polar nations around the world. The new group draws together museums, schools, universities, science centers, formal and informal education, expeditions, NGOs, companies, governmental organizations, and non-profits. Working across national, disciplinary, and age group boundaries, we want to improve polar science & education for the next generation of policy makers, entrepreneurs, explorers, citizen scientists, journalists and educators; as well as the the public. The new network of more than 200 leading educators, scientists, and community members will develop innovative resources to communicate polar science. We intend to engage those learning and teaching about the polar regions, and thereby change the terms of debate, and the framework of education to rekindle student and public engagement with global environmental changes. We are committed to engaging our membership and have clear directions from our recent survey and report from the community. This presentation will address the needs put forth from our membership and where the organization will go in the future to inform a professional network on science and outreach in the polar regions.

Comparison of clinical outcome after autologous stem cell transplantation between patients with peripheral T-cell lymphomas and diffuse large B-cell lymphoma.

PubMed

Sohn, B S; Park, I; Kim, E K; Yoon, D H; Lee, S S; Kang, B W; Jang, G; Choi, Y H; Kim, C; Lee, D H; Kim, S; Huh, J; Suh, C

2009-09-01

Although patients with T-cell phenotype lymphomas are generally accepted to have worse prognosis than B-cell phenotype lymphomas, the studies comparing outcomes after autologous stem cell transplantation (ASCT) between peripheral T-cell lymphomas (PTCLs) and with diffuse large B-cell lymphoma (DLBCL) are few. In this study, we compared outcomes after ASCT between 23 patients with PTCLs and 54 patients with DLBCL. Univariate analysis showed that the timing of ASCT, complete response (CR) at ASCT, favorable lactate dehydrogenase/performance/stage, low/low-intermediate (L-LI) International Prognostic Index (IPI) and L-LI age-adjusted IPI (aaIPI) at ASCT were significant predictors of both OS and EFS. Multivariate analysis showed that CR and L-LI aaIPI at ASCT were favorable for both OS (hazard ratio (HR), 0.34; 95% CI, 0.14-0.81; P=0.016 and HR, 0.27; 95% CI, 0.12-0.57; P=0.001) and EFS (HR, 0.38; 95% CI, 0.17-0.85; P=0.020 and HR, 0.36; 95% CI, 0.17-0.77; P=0.008). B-cell or T-cell phenotype, however, had no impact on OS (HR, 0.56; 95% CI, 0.27-1.18; P=0.126) or EFS (HR, 0.62; 95% CI, 0.30-1.30; P=0.206). In conclusion, when compared to patients with DLBCL, patients with PTCLs did not have inferior outcomes after ASCT. T-cell phenotype itself may not have an effect on outcomes of PTCL patients who underwent ASCT.

Go Polar! Network: a Museum-Zoo-Aquarium Approach to Disseminate IPY Research to Children and their Families

NASA Astrophysics Data System (ADS)

Williams, D. D.; Horne, C.

2006-12-01

With proper programming, informal learning environments of children's museums, zoos and aquariums can be fertile frontiers for communicating the excitement, the significance and even the complexity of Polar scientific research to the public, including children under 12 old. These venues can also be effective in enhancing public understanding of the global dimensions of the issues facing the Polar Regions in the coming decades. We base these assertions not just on scholarly research in how children learn in informal environments but also from an experiential program we created in 2003-04 called Go Polar! Cool Science in the Arctic. Funded by the US National Science Foundation in 2003 (ESI-0336928), Go Polar! was a partnership between the EdVenture Children Museum, the largest children's museum in the southeastern US, and the University of South Carolina, the State's largest research university. Go Polar! involved active Arctic researchers, university undergraduate students, the EdVenture museum staff, family education specialists, and educational psychologists to disseminate on-going NSF funded research on the Arctic hydrologic cycle (ODP-0229737). The Go Polar program provided opportunities for South Carolina children and families to meet real scientists engaged in Arctic research with hands-on activities that introduced children and families not only to the scientific process but also to new science concepts and knowledge. The Go Polar! also resulted in the development and testing of new educational materials Arctic Discovery Boxes specially designed hands-on informal education activities on three themes #1 The Arctic and Global Change, #2 Arctic Cultures and #3 Animal Adaptations in the Arctic. In 2005 the Go Polar! partnership expanded the reach of their programming and materials to include the Antarctic. Using the theme "Exploring and Connecting the Opposite Ends of the Earth," the Go Polar! team created a Polar Festival featuring a giant floor puzzle of the Arctic and Antarctic with the ocean basins and surrounding continents connecting the poles (http://schc.sc.edu/gopolar/). Having received endorsement from the IPY Education and Outreach Committee, our plans are to disseminate the Go Polar! programming through a national and even international network of museums, zoos and aquariums.

Live from the Arctic

NASA Astrophysics Data System (ADS)

Warnick, W. K.; Haines-Stiles, G.; Warburton, J.; Sunwood, K.

2003-12-01

For reasons of geography and geophysics, the poles of our planet, the Arctic and Antarctica, are places where climate change appears first: they are global canaries in the mine shaft. But while Antarctica (its penguins and ozone hole, for example) has been relatively well-documented in recent books, TV programs and journalism, the far North has received somewhat less attention. This project builds on and advances what has been done to date to share the people, places, and stories of the North with all Americans through multiple media, over several years. In a collaborative project between the Arctic Research Consortium of the United States (ARCUS) and PASSPORT TO KNOWLEDGE, Live from the Arctic will bring the Arctic environment to the public through a series of primetime broadcasts, live and taped programming, interactive virtual field trips, and webcasts. The five-year project will culminate during the 2007-2008 International Polar Year (IPY). Live from the Arctic will: A. Promote global understanding about the value and world -wide significance of the Arctic, B. Bring cutting-edge research to both non-formal and formal education communities, C. Provide opportunities for collaboration between arctic scientists, arctic communities, and the general public. Content will focus on the following four themes. 1. Pan-Arctic Changes and Impacts on Land (i.e. snow cover; permafrost; glaciers; hydrology; species composition, distribution, and abundance; subsistence harvesting) 2. Pan-Arctic Changes and Impacts in the Sea (i.e. salinity, temperature, currents, nutrients, sea ice, marine ecosystems (including people, marine mammals and fisheries) 3. Pan-Arctic Changes and Impacts in the Atmosphere (i.e. precipitation and evaporation; effects on humans and their communities) 4. Global Perspectives (i.e. effects on humans and communities, impacts to rest of the world) In The Earth is Faster Now, a recent collection of comments by members of indigenous arctic peoples, arctic residents speak in eloquent terms of the changes they see around them, manifested in new patterns of vegetation, the melting of permafrost and the absence of game species that used to be abundant. Meanwhile, new satellites and more sophisticated sensors on the ground and in the ice, add scientific testimony that seems to support and even extend native perceptions. Live from the Arctic will unify both perspectives, and use todays most powerful and effective communications media to connect young people and general audiences all across America to researchers and communities living and working in the Arctic. During IPY there will be a level of interest in the Polar regions unprecedented in a generation. Live from the Arctic offers unique resources to satisfy that curiosity, and encourage active participation and engagement in understanding some of Earths most significant peoples, places and rapidly changing conditions.

Establishment of the International Power Institute. Final technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Julius E. Coles

The International Power Institute, in collaboration with American industries, seeks to address technical, political, economic and cultural issues of developing countries in the interest of facilitating profitable transactions in power related infrastructure projects. IPI works with universities, governments and commercial organizations to render project-specific recommendations for private-sector investment considerations. IPI also established the following goals: Facilitate electric power infrastructure transactions between developing countries and the US power industry; Collaborate with developing countries to identify development strategies to achieve energy stability; and Encourage market driven solutions and work collaboratively with other international trade energy, technology and banking organizations.

Geriatric nutritional risk index as a prognostic factor in patients with diffuse large B cell lymphoma.

PubMed

Kanemasa, Yusuke; Shimoyama, Tatsu; Sasaki, Yuki; Hishima, Tsunekazu; Omuro, Yasushi

2018-06-01

The geriatric nutritional risk index (GNRI) is a simple and well-established nutritional assessment tool that is a significant prognostic factor for various cancers. However, the role of the GNRI in predicting clinical outcomes of diffuse large B cell lymphoma (DLBCL) patients has not been investigated. To address this issue, we retrospectively analyzed a total of 476 patients with newly diagnosed de novo DLBCL. We defined the best cutoff value of the GNRI as 96.8 using a receiver operating characteristic curve. Patients with a GNRI < 96.8 had significantly lower overall survival (OS) and progression-free survival (PFS) than those with a GNRI ≥ 96.8 (5-year OS, 61.2 vs. 84.4%, P < 0.001; 5-year PFS, 53.7 vs. 75.8%, P < 0.001). Multivariate analysis showed that performance status, Ann Arbor stage, serum lactate dehydrogenase, and GNRI were independent prognostic factors for OS. Among patients with high-intermediate and high-risk by National Comprehensive Cancer Network-International Prognostic Index (NCCN-IPI), the 5-year OS was significantly lower in patients with a GNRI < 96.8 than in those with a GNRI ≥ 96.8 (high-intermediate risk, 59.5 vs. 75.2%, P = 0.006; high risk, 37.4 vs. 64.9%, P = 0.033). In the present study, we demonstrated that the GNRI was an independent prognostic factor in DLBCL patients. The GNRI could identify a population of poor-risk patients among those with high-intermediate and high-risk by NCCN-IPI.

A new prognostic model identifies patients aged 80 years and older with diffuse large B-cell lymphoma who may benefit from curative treatment: A multicenter, retrospective analysis by the Spanish GELTAMO group.

PubMed

Pardal, Emilia; Díez Baeza, Eva; Salas, Queralt; García, Tomás; Sancho, Juan M; Monzón, Encarna; Moraleda, José M; Córdoba, Raúl; de la Cruz, Fátima; Queizán, José A; Rodríguez, María J; Navarro, Belén; Hernández, José A; Díez, Rosana; Vahi, María; Viguria, María C; Canales, Miguel; Peñarrubia, María J; González-López, Tomás J; Montes-Moreno, Santiago; González-Barca, Eva; Caballero, Dolores; Martín, Alejandro

2018-04-15

The means of optimally managing very elderly patients with diffuse large B-cell lymphoma (DLBCL) has not been established. We retrospectively analyzed 252 patients aged 80-100 years, diagnosed with DLBCL or grade 3B follicular lymphoma, treated in 19 hospitals from the GELTAMO group. Primary objective was to analyze the influence of the type of treatment and comorbidity scales on progression-free survival (PFS) and overall survival (OS). One hundred sixty-three patients (63%) were treated with chemotherapy that included anthracyclines and/or rituximab, whereas 15% received no chemotherapeutic treatment. With a median follow-up of 44 months, median PFS and OS were 9.5 and 12.5 months, respectively. In an analysis restricted to the 205 patients treated with any kind of chemotherapy, comorbidity scales did not influence the choice of treatment type significantly. Independent factors associated with better PFS and OS were: age < 86 years, cumulative illness rating scale (CIRS) score < 6, intermediate risk (1-2) R-IPI, and treatment with R-CHOP at full or reduced doses. We developed a prognostic model based on the multivariate analysis of the 108 patients treated with R-CHOP-like: median OS was 45 vs. 12 months (P = .001), respectively, for patients with 0-1 vs. 2-3 risk factors (age > 85 years, R-IPI 3-5 or CIRS > 5). In conclusion, treatment with R-CHOP-like is associated with good survival in a significant proportion of patients. We have developed a simple prognostic model that may aid the selection patients who could benefit from a curative treatment, although it needs to be validated in larger series. © 2018 Wiley Periodicals, Inc.

Co-infection of HIV and intestinal parasites in rural area of China

PubMed Central

2012-01-01

Background Intestinal parasite infections (IPIs) are among the most significant causes of illness and disease of socially and economically disadvantaged populations in developing countries, including rural areas of the People's Republic of China. With the spread of the human immunodeficiency virus (HIV) among rural Chinese populations, there is ample scope for co-infections and there have been increasing fears about their effects. However, hardly any relevant epidemiological studies have been carried out in the country. The aim of the present survey was to assess the IPI infection status among a representative sample of HIV-positive Chinese in rural Anhui province, and compare the findings with those from a cohort of non-infected individuals. Methods A case control study was carried out in a rural village of Fuyang, Anhui province, China. Stool samples of all participants were examined for the presence of intestinal parasites. Blood examination was performed for the HIV infection detection and anemia test. A questionnaire was administered to all study participants. Results A total of 302 HIV positive and 303 HIV negative individuals provided one stool sample for examination. The overall IPI prevalence of intestinal helminth infections among HIV positives was 4.3% (13/302) while it was 5.6% (17/303) among HIV negatives, a non-significant difference. The prevalence of protozoa infections among HIV positives was 23.2% while the rate was 25.8% among HIV negatives. The species-specific prevalences among HIV positives were as follows: 3.6% for hookworm, 0.7% for Trichuris trichiura, zero for Ascaris lumbricoides, 0.3% for Clonorchis sinensis, 1.3% for Giardia intestinalis, 16.2% for Blastocystis hominis, 1.7% for Entamoeba spp. and 8.3% for Cryptosporidium spp.. Cryptosporidium spp. infections were significantly more prevalent among HIV positives (8.3%) compared to the HIV negative group (3.0%; P < 0.05). Among people infected with HIV, Cryptosporidium spp. was significantly more prevalent among males (12.6%) than females (4.4%; P < 0.05). According to multivariate logistic regression, the factors significantly associated with parasite infections of the people who were HIV positive included sex (male: OR = 6.70, 95% CI: 2.030, 22.114), younger age (less than 42 years old: OR = 4.148, 95% CI: 1.348, 12.761), and poor personal hygiene habits (OR = 0.324, 95% CI: 0.105, 0.994). Conclusions HIV positive individuals are more susceptible to co-infections with Cryptosporidium spp. than HIV negative people, particularly younger males with poor personal hygiene habits, indicating a need for targeted hygiene promotion, IPI surveillance and treatment. PMID:22330320

"Got Snow?" Education and Outreach for the IPY

NASA Astrophysics Data System (ADS)

Turrin, M.; Bell, R. E.; Pfirman, S.; Maru, P.

2004-12-01

The "Bridging the Poles: Education Linked with Research" workshop of June 23-25, brought together an international group of 65 scientists, educators and media specialists to define strategies to engage the next generation of polar scientists, engineers and leaders, and inspire the general public. The workshop results emphasized the need to leverage emerging science programs with meaningful education and outreach programming that is rolled out to the public as major media events. Participants advocated a broad interdisciplinary approach, recognizing that the poles have a rich cultural heritage and fascinating history. Linking research events with student fascination about polar environments, peoples and histories of exploration, can help improve science, math, reading, and other skills. Distance learning with web course delivery is a powerful tool to reach advanced students and to help develop a new generation of researchers among Arctic indigenous peoples. Successful examples of this approach include the University of the Arctic's PhD network, and collaborative field courses. Field experiences build life-long advocates of the poles for students, teachers, and the media alike. Establishing connections among scientists, educators and informal outreach venues in their own community, can have long-lasting impact. "Think Globally/Act Locally" and the complementary "Think Locally/Act Globally" will be important themes for local, national and international IPY programming. Imagine a semi-trailer truck labeled "Got Snow?" traversing the country loaded with polar gear, interactive activities and a snowmaker; polar exhibitions opening at natural history and art museums and zoos; polar-themed postage stamps; national polar book-of-the-month recommendations; made-for-TV polar documentaries; and a rich, multidisciplinary and multilingual web portal. To meet these opportunities requires coordination, linking communities, and high-bandwidth access to high quality content from the polar regions. We need to start now to develop an integrated research/media/education strategy; establish partners among the research, media, and education communities; and diversify participation and audiences.

Ice Velocity Mapping in Antarctica - Towards a Virtual Satellite Constellation

NASA Astrophysics Data System (ADS)

Scheuchl, B.; Mouginot, J.; Rignot, E. J.; Crevier, Y.

2013-12-01

Ice sheets are acknowledged by the World Meteorological Organization (WMO) and the United Nations Framework Convention on Climate Change (UNFCCC) as an Essential Climate Variable (ECV) needed to make significant progress in the generation of global climate products and derived information. Ice velocity is a crucial geophysical parameter that can be measured using spaceborne Synthetic Aperture Radar (SAR) data. Here, we report on an update to available Earth System Data Records (ESDR) of ice velocity in Antarctica based on data from a suite of spaceborne (SAR) sensors and provide an overview on international coordination in an effort to best utilize the available SAR satellites. Building on the first complete mapping of the flow of ice surface over the Antarctic continent using data predominantly acquired during IPY, we are working on a series of regional studies analyzing data from several different epochs. The analysis of velocity changes between discrete measurements requires even more careful data processing in order to be able to accurately measure subtle changes. Examples for Larsen-C and the Amundsen Sea Embayment will be presented. Data continuity is a crucial aspect to this work, particularly in light of the fact that 4 SAR missions have ceased operations since IPY and all available missions have a primary mandate that is not scientific data collection. Following the successful internationally coordinated SAR data acquisitions over ice sheets during the International Polar Year 2007/2008, efforts are undertaken to continue data acquisitions in the spirit of collaboration. The Polar Space Task Group (PSTG) is succeeding the IPY coordinating body of international space agencies, Space Task Group (STG). The PSTG SAR Coordination Working Group was created to address the issue of SAR data acquisitions in the cryosphere. A review of ice sheet requirements was undertaken by the science community, presented to PSTG, and followed up with a set of sensor specific recommendations. PSTG includes this information in coordinated acquisition planning going forward. In 2013 the Canadian Space Agency committed RADARSAT-2 to a large scale Antarctic data acquisition campaign. This effort will be supported in the near future by the European Space Agency and the Japan Space Exploration Agency once Sentinel-1 and ALOS-2 are launched. In addition, the German Space Agency and the Italian Space Agency acquire high resolution SAR data in high priority sites. We provide an overview of high-level plans and show first results from the RADARSAT-2 campaign. Data analysis and ESDR production is conducted at the Department of Earth System Science, University of California Irvine under a contract with the National Aeronautics and Space Administration's MEaSUREs program. Spaceborne SAR data are made available courtesy of the Polar Space Task Group.

Prognostic value of interim FDG-PET in R-CHOP-treated diffuse large B-cell lymphoma: Systematic review and meta-analysis.

PubMed

Adams, Hugo J A; Kwee, Thomas C

2016-10-01

This study aimed to systematically review and meta-analyze the prognostic value of interim (18)F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) in diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP). MEDLINE and EMBASE were systematically searched for suitable studies. Included studies were methodologically appraised, and results were summarized both descriptively and meta-analytically. Nine studies, comprising a total of 996 R-CHOP-treated DLBCL patients, were included. Overall, studies were of moderate methodological quality. The area under the summary receiver operating curve (AUC) of interim FDG-PET in predicting treatment failure and death were 0.651 and 0.817, respectively. There was no heterogeneity in diagnostic odds ratios across available studies (I(2)=0.0%). At multivariable analysis, 2 studies reported interim FDG-PET to have independent prognostic value in addition to the International Prognostic Index (IPI) in predicting treatment failure, whereas 3 studies reported that this was not the case. One study reported interim FDG-PET to have independent prognostic value in addition to the IPI in predicting death, whereas 2 studies reported that this was not the case. In conclusion, interim FDG-PET in R-CHOP-treated DLBCL has some correlation with outcome, but its prognostic value is homogeneously suboptimal across studies and it has not consistently proven to surpass the prognostic potential of the IPI. Moreover, there is a lack of studies that compared interim FDG-PET to the recently developed and superior National Comprehensive Cancer Network-IPI. Therefore, at present there is no scientific base to support the clinical use of interim FDG-PET in R-CHOP-treated DLBCL. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Blunted day-night changes in luteinizing hormone pulse frequency in girls with obesity: the potential role of hyperandrogenemia.

PubMed

Collins, Jessicah S; Beller, Jennifer P; Burt Solorzano, Christine; Patrie, James T; Chang, R Jeffrey; Marshall, John C; McCartney, Christopher R

2014-08-01

Puberty is marked by sleep-associated changes in LH pulse frequency and amplitude. Early pubertal girls with obesity exhibit blunted day-to-night changes in LH secretion; whether this occurs in late pubertal obese girls is unknown. The objective of the study was to test two hypotheses: 1) blunted day-to-night changes in LH secretion occur in both early and late pubertal obese girls, and 2) such alterations are specifically associated with hyperandrogenemia. This was a cross-sectional analysis. The study was conducted at a clinical research center. Twenty-seven early pubertal, premenarcheal girls (12 of whom were obese) and 63 late pubertal (postmenarcheal) girls (27 of whom were obese) participated in the study. Blood samples were taken every 10 minutes from 7:00 pm to 7:00 am. Change in LH pulse frequency [LH interpulse interval (IPI)] from daytime hours (7:00 pm-11:00 pm, while awake) to nighttime hours (11:00 pm to 7:00 am, while generally asleep). Both nonobese and obese postmenarcheal girls demonstrated significant day-to-night decreases in LH pulse frequency (IPI increases of 33% and 16%, respectively), but day-to-night changes were blunted in obese girls (P = .004, obese vs nonobese). Day-to-night LH pulse frequency decreased significantly in postmenarcheal obese subjects with normal T concentrations (26% IPI increase) but not in those with hyperandrogenemia. Similar differences were evident for LH pulse amplitude. Nonobese and obese early pubertal girls exhibited nonsignificant differences in day-night LH pulse frequency (day to night IPI increase of 26% vs decrease of 1%, respectively). Day-to-night changes in LH pulse secretion are blunted in postmenarcheal obese adolescent girls. This phenomenon may in part reflect hyperandrogenemia.

Multiple ECG Fiducial Points-Based Random Binary Sequence Generation for Securing Wireless Body Area Networks.

PubMed

Zheng, Guanglou; Fang, Gengfa; Shankaran, Rajan; Orgun, Mehmet A; Zhou, Jie; Qiao, Li; Saleem, Kashif

2017-05-01

Generating random binary sequences (BSes) is a fundamental requirement in cryptography. A BS is a sequence of N bits, and each bit has a value of 0 or 1. For securing sensors within wireless body area networks (WBANs), electrocardiogram (ECG)-based BS generation methods have been widely investigated in which interpulse intervals (IPIs) from each heartbeat cycle are processed to produce BSes. Using these IPI-based methods to generate a 128-bit BS in real time normally takes around half a minute. In order to improve the time efficiency of such methods, this paper presents an ECG multiple fiducial-points based binary sequence generation (MFBSG) algorithm. The technique of discrete wavelet transforms is employed to detect arrival time of these fiducial points, such as P, Q, R, S, and T peaks. Time intervals between them, including RR, RQ, RS, RP, and RT intervals, are then calculated based on this arrival time, and are used as ECG features to generate random BSes with low latency. According to our analysis on real ECG data, these ECG feature values exhibit the property of randomness and, thus, can be utilized to generate random BSes. Compared with the schemes that solely rely on IPIs to generate BSes, this MFBSG algorithm uses five feature values from one heart beat cycle, and can be up to five times faster than the solely IPI-based methods. So, it achieves a design goal of low latency. According to our analysis, the complexity of the algorithm is comparable to that of fast Fourier transforms. These randomly generated ECG BSes can be used as security keys for encryption or authentication in a WBAN system.

The effectiveness of regional anaesthesia before and after the introduction of a dedicated regional anaesthesia service incorporating a block room.

PubMed

Chin, A; Heywood, L; Iu, P; Pelecanos, A M; Barrington, M J

2017-11-01

Dedicated regional anaesthesia services incorporating block rooms and/or block teams may facilitate theatre efficiency and improve training in regional anaesthesia. Currently, it is unknown if a dedicated regional anaesthesia service improves the effectiveness of regional anaesthesia. In November 2013, the Royal Brisbane and Women's Hospital established a dedicated regional anaesthesia service comprising a block team and a block room. Pre-intervention (conventional model of care) registry data was retrospectively compared with post-intervention (dedicated regional anaesthesia service) audit data, with regard to pain and opioid requirement in the post-anaesthesia care unit (PACU). The primary outcome was inadequate analgesia, defined as a numerical rating scale (NRS; 0, no pain; 10, worst pain imaginable) for pain >5 in the PACU. Pre- and post-intervention, 43.7% and 27.7% of patients respectively reported a NRS >5 (P <0.001). A difference in the type of blocks and surgery performed may have accounted for the improved outcome seen post-intervention. After adjustment for American Society of Anesthesiologists physical status, block type and surgery type, the odds ratio of having inadequate analgesia (NRS >5) was 0.54 (95% confidence interval 0.39 to 0.76) for post-intervention compared to pre-intervention. Secondary outcomes examined pre- and post-intervention were the absence of pain (39.3% and 55.1% of patients, respectively, P <0.001), systemic opioid analgesia requirement (48.6% and 30.5% of patients respectively, P <0.001) and median maximum NRS (4 [interquartile range (IQR) 0 to 8] and 0 [IQR 0 to 6] respectively, P <0.001). A dedicated regional anaesthesia service was associated with improved effectiveness of regional anaesthesia.

IPY to Mark Expansion of Research Facilities on the North Slope of Alaska

NASA Astrophysics Data System (ADS)

Zak, B. D.; Eicken, H.; Sheehan, G. W.; Glenn, R.

2004-12-01

The Barrow Global Climate Change Research Facility will open to researchers on the North Slope of Alaska during the 2007-08 anniversary of the first IPY. Between 1949 and 1980, arctic researchers were very active on the North Slope and in nearby waters largely because of the Naval Arctic Research Laboratory (NARL) at Barrow. NARL provided easy access, laboratories and logistical support. NARL was closed in 1981, but particularly during this past decade, Barrow-based arctic research projects have been back on the upswing. The National Oceanic and Atmospheric Administration (NOAA) Climate Monitoring and Diagnostics Laboratory (CMDL) Barrow station was founded during the 1970s, and continues as part of NOAA's five station global network for monitoring atmospheric composition. The North Slope Borough's Department of Wildlife Management (DWM) has for the past 20 years conducted its own research. The DWM also served as logistical provider for growing numbers of arctic researchers without other logistical support. In the late 1990s, the Department of Energy Atmospheric Radiation Measurement program (ARM: DOE's principal climate change research effort) created a Cloud and Radiation Testbed on the North Slope with atmospheric instrumentation at Barrow and Atqasuk. It is now part of the ARM Climate Research Facility, a National User Facility. In response to growing researcher needs, the Barrow Arctic Science Consortium (BASC) was formed in the late 1990s as a non-profit logistical support and community coordinating organization, and received the endorsement of Ukpeagvik Inupiat Corporation (UIC), NSB and the local community college. BASC provides logistical support to National Science Foundation (NSF) researchers through a cooperative agreement, and to others on a fee for service basis. UIC also dedicated 11 square miles of its land as the Barrow Environmental Observatory (BEO), and charged BASC with management of the BEO. This land that has been used for research for more than 50 years, and now is available to the larger research community through BASC. It has been protected from development by the NSB Assembly as a Scientific Research District. Since 1981, the remains of the old NARL infrastructure sustained the scientific enterprise on the North Slope. But now, as a result of the rapid ongoing changes in the Arctic, these old inadequate facilities are about to be replaced. The new Barrow facility, although smaller than the old NARL, will serve the needs of modern researchers with first class laboratories, information technology and lodging. It is being designed by the arctic research community itself through a series of workshops held over this past year, and through ongoing feedback (http://scifac.arcticscience.org). Research on the North Slope capitalizes on the history of collaboration between the Native Inupiat Eskimo people and scientists going back to the first IPY. Local native people have served in many support capacities for scientists in the past, and currently serve as managers and technicians for projects like ARM. It is this history of collaboration with scientists that inspired the creation of BASC, of the BEO, and that made the new facility possible. This paper reviews the status of planning for the new Barrow facility. Feedback can be provided through the web site and through the authors, who serve BASC respectively as chairs of advisory committees, Executive Director and President.

The Scientific Committee on Antarctic Research (SCAR) in the IPY 2007-2009

NASA Astrophysics Data System (ADS)

Kennicutt, M. C.; Wilson, T. J.; Summerhayes, C.

2005-05-01

The Scientific Committee on Antarctic Research (SCAR) initiates, develops, and coordinates international scientific research in the Antarctic region. SCAR is assuming a leadership position in the IPY primarily through its five major Scientific Research Programs; ACE, SALE, EBA, AGCS, and ICESTAR; which will be briefly described.Antarctic Climate Evolution (ACE) promotes the exchange of data and ideas between research groups focusing on the evolution of Antarctica's climate system and ice sheet. The program will: (1) quantitatively assess the climate and glacial history of Antarctica; (2) identify the processes which govern Antarctic change and feed back around the globe; (3) improve our ability to model past changes in Antarctica; and (4)document past change to predict future change in Antarctica. Subglacial Antarctic Lake Environments (SALE) promotes, facilitates, and champions cooperation and collaboration in the exploration and study of subglacial environments in Antarctica. SALE intends to understand the complex interplay of biological, geological, chemical, glaciological, and physical processes within subglacial lake environments through coordinated international research teams. Evolution and Biodiversity in the Antarctic (EBA) will use a suite of modern techniques and interdisciplinary approaches, to explore the evolutionary history of selected modern Antarctic biota, examine how modern biological diversity in the Antarctic influences the way present-day ecosystems function, and thereby predict how the biota may respond to future environmental change. Antarctica and the Global Climate System (AGCS) will investigate the nature of the atmospheric and oceanic linkages between the climate of the Antarctic and the rest of the Earth system, and the mechanisms involved therein. A combination of modern instrumented records of atmospheric and oceanic conditions, and the climate signals held within ice cores will be used to understand past and future climate variability and change in the Antarctic as a result of natural and anthropogenic forcings over the last 100,000 years. Interhemispheric Conjugacy Effects in Solar-Terrestrial and Aeronomy Research (ICESTAR) will study the interactions between and collective behavior of the many component parts of the Earth system, including the interaction between the natural environment and human society. Objectives include specification and prediction of the state of the system and assimilation and integration of data from disparate sources to understand the complex geospace environment.

The subtle balance of weak supramolecular interactions: The hierarchy of halogen and hydrogen bonds in haloanilinium and halopyridinium salts.

PubMed

Raatikainen, Kari; Cametti, Massimo; Rissanen, Kari

2010-01-15

THE SERIES OF HALOANILINIUM AND HALOPYRIDINIUM SALTS: 4-IPhNH₃Cl (1), 4-IPhNH₃Br (5), 4-IPhNH₃H₂PO₄ (6), 4-ClPhNH₃H₂PO₄ (8), 3-IPyBnCl (9), 3-IPyHCl (10) and 3-IPyH-5NIPA (3-iodopyridinium 5-nitroisophthalate, 13), where hydrogen or/and halogen bonding represents the most relevant non-covalent interactions, has been prepared and characterized by single crystal X-ray diffraction. This series was further complemented by extracting some relevant crystal structures: 4-BrPhNH₃Cl (2, CCDC ref. code TAWRAL), 4-ClPhNH₃Cl (3, CURGOL), 4-FPhNH₃Cl (4, ANLCLA), 4-BrPhNH₃H₂PO₄, (7, UGISEI), 3-BrPyHCl, (11, CIHBAX) and 3-ClPyHCl, (12, VOQMUJ) from Cambridge Structural Database for sake of comparison. Based on the X-ray data it was possible to highlight the balance between non-covalent forces acting in these systems, where the relative strength of the halogen bonding C-X...A⁻ (X = I, Br or Cl) and the ratio between the halogen and hydrogen bonds [C-X...A⁻ : D-H...A⁻] varied across the series.

Outcome of patients with relapsed diffuse large B-cell lymphoma who fail second-line salvage regimens in the International CORAL study.

PubMed

Van Den Neste, E; Schmitz, N; Mounier, N; Gill, D; Linch, D; Trneny, M; Milpied, N; Radford, J; Ketterer, N; Shpilberg, O; Dührsen, U; Ma, D; Brière, J; Thieblemont, C; Salles, G; Moskowitz, C H; Glass, B; Gisselbrecht, C

2016-01-01

Salvage chemotherapy followed by autologous stem cell transplantation (ASCT) is the standard second-line treatment for relapsed and refractory diffuse large B-cell lymphoma (DLBCL). However, the strategy is less clear in patients who require third-line treatment. Updated outcomes of 203 patients who could not proceed to scheduled ASCT in the Collaborative Trial in Relapsed Aggressive Lymphoma (CORAL) are herein reviewed. In the intent-to-treat analysis, overall response rate to third-line chemotherapy was 39%, with 27% CR or CR unconfirmed, and 12% PR. Among the 203 patients, 64 (31.5%) were eventually transplanted (ASCT 56, allogeneic SCT 8). Median overall survival (OS) of the entire population was 4.4 months. OS was significantly improved in patients with lower tertiary International Prognostic Index (IPI), patients responding to third-line treatment and patients transplanted with a 1-year OS of 41.6% compared with 16.3% for the not transplanted (P<0.0001). In multivariate analysis, IPI at relapse (hazard ratio (HR) 2.409) and transplantation (HR 0.375) independently predicted OS. Third-line salvage chemotherapy can lead to response followed by transplantation and long-term survival in DLBCL patients. However, improvement of salvage efficacy is an urgent need with new drugs.

Detecting trends in academic research from a citation network using network representation learning

PubMed Central

Mori, Junichiro; Ochi, Masanao; Sakata, Ichiro

2018-01-01

Several network features and information retrieval methods have been proposed to elucidate the structure of citation networks and to detect important nodes. However, it is difficult to retrieve information related to trends in an academic field and to detect cutting-edge areas from the citation network. In this paper, we propose a novel framework that detects the trend as the growth direction of a citation network using network representation learning(NRL). We presume that the linear growth of citation network in latent space obtained by NRL is the result of the iterative edge additional process of a citation network. On APS datasets and papers of some domains of the Web of Science, we confirm the existence of trends by observing that an academic field grows in a specific direction linearly in latent space. Next, we calculate each node’s degree of trend-following as an indicator called the intrinsic publication year (IPY). As a result, there is a correlation between the indicator and the number of future citations. Furthermore, a word frequently used in the abstracts of cutting-edge papers (high-IPY paper) is likely to be used often in future publications. These results confirm the validity of the detected trend for predicting citation network growth. PMID:29782521

Eigenvalues of Covariance Matrix for Two-Source Array Processing

DTIC Science & Technology

1990-11-01

Using (IpI1I) 2 - !p1 2(1 - lp2). . = p 72 - (-1 + 11 1 - J J21 - Ipl2 ) - -(1 - Ip12) + (1 + ) 21 and setting to zero the derivative of the above...A2 decreases from A2(- pI 101, (1 - 1012)(1 - Ip12)) = (1 - IPIO) - 1 Ipl1l) 2 -(1 1012)(1 - Ipl2 ) = (1 - Ipll0l) - IlPI - I011, to A2(0,(1 - 11 2 )(1...IP12)) = 1 - 1- (1 - 112 )(1 - I1p2), to A2(IPIIOI, (1 - 102 )(1 - IPl2 )) = (1 + IPI1l) - 01T IP111) 2 - (1 - 112)(1 - Ipl2 ) = (1 + Ipll01) - (Ipl

Theory of the high-frequency chiral optical response of a p(x) + ip(y) superconductor.

PubMed

Yakovenko, Victor M

2007-02-23

The optical Hall conductivity and the polar Kerr angle are calculated as functions of temperature for a two-dimensional chiral p(x) + ip(y) superconductor, where the time-reversal symmetry is spontaneously broken. The theoretical estimate for the polar Kerr angle agrees by the order of magnitude with the recent experimental measurement in Sr2RuO4 by Xia et al. [Phys. Rev. Lett. 97, 167002 (2006)10.1103/PhysRevLett.97.167002]. The theory predicts that the Kerr angle is proportional to the square of the superconducting energy gap and is inversely proportional to the cube of frequency, which can be verified experimentally.

Environmental risk of heavy metal pollution and contamination sources using multivariate analysis in the soils of Varanasi environs, India.

PubMed

Singh, Shubhra; Raju, N Janardhana; Nazneen, Sadaf

2015-06-01

This study assessed soil pollution in the Varanasi environs of Uttar Pradesh in India. Assessing the concentration of potentially harmful heavy metals in the soils is imperative in order to evaluate the potential risks to human. To identify the concentration and sources of heavy metals and assess the soil environmental quality, 23 samples were collected from different locations covering dumping, road and agricultural area. The average concentrations of the heavy metals were all below the permissible limits according to soil quality guidelines except Cu (copper) and Pb (lead) in dumping and road soils. Soil heavy metal contamination was assessed on the basis of geoaccumulation index (Igeo), pollution index (PI) and integrated pollution index (IPI). The IPI of the metals ranged from 0.59 to 9.94, with the highest IPI observed in the dumping and road soils. A very significant correlation was found between Pb and Cu. The result of principal component analysis suggested that PC1 was mainly affected by the use of agrochemicals, PC2 was affected by vehicular emission and PC3 was affected by dumping waste. Meanwhile, PC4 was mainly controlled by parent material along with anthropogenic activities. Appropriate measures should be taken to minimize the heavy metal levels in soils and thus protect human health.

Auxin Produced by the Indole-3-Pyruvic Acid Pathway Regulates Development and Gemmae Dormancy in the Liverwort Marchantia polymorpha[OPEN

PubMed Central

Eklund, D. Magnus; Ishizaki, Kimitsune; Flores-Sandoval, Eduardo; Kikuchi, Saya; Takebayashi, Yumiko; Tsukamoto, Shigeyuki; Hirakawa, Yuki; Nonomura, Maiko; Kato, Hirotaka; Kouno, Masaru; Bhalerao, Rishikesh P.; Lagercrantz, Ulf; Kasahara, Hiroyuki; Kohchi, Takayuki; Bowman, John L.

2015-01-01

The plant hormone auxin (indole-3-acetic acid [IAA]) has previously been suggested to regulate diverse forms of dormancy in both seed plants and liverworts. Here, we use loss- and gain-of-function alleles for auxin synthesis- and signaling-related genes, as well as pharmacological approaches, to study how auxin regulates development and dormancy in the gametophyte generation of the liverwort Marchantia polymorpha. We found that M. polymorpha possess the smallest known toolkit for the indole-3-pyruvic acid (IPyA) pathway in any land plant and that this auxin synthesis pathway mainly is active in meristematic regions of the thallus. Previously a Trp-independent auxin synthesis pathway has been suggested to produce a majority of IAA in bryophytes. Our results indicate that the Trp-dependent IPyA pathway produces IAA that is essential for proper development of the gametophyte thallus of M. polymorpha. Furthermore, we show that dormancy of gemmae is positively regulated by auxin synthesized by the IPyA pathway in the apex of the thallus. Our results indicate that auxin synthesis, transport, and signaling, in addition to its role in growth and development, have a critical role in regulation of gemmae dormancy in M. polymorpha. PMID:26036256

Influence of sample pool on interference pattern in defocused interferometric particle imaging.

PubMed

Zhang, Hongxia; Zhou, Ye; Liu, Jing; Jia, Dagong; Liu, Tiegen

2017-04-01

Particles widely exist in various fields. In practical experiments, sometimes it is necessary to dissolve particles in water in a sample pool. This article proposes two typical layouts of the sample pool in defocused interferometric particle imaging (IPI). Layout I is the sample pool surface perpendicular to the incident light and layout II is the sample pool surface perpendicular to the scattered light. For layout I, the scattered light of the particles does not keep symmetric at the meridional and sagittal planes after being refracted by the sample pool surface, and elliptical interference patterns are formed at the defocused IPI image plane. But for layout II, the scattered light keeps symmetric after being refracted, and circular interference patterns are formed. Aimed at the two sample pool layouts, the ray-tracing software ZEMAX was used to simulate the spot shape of particles at different defocus distances. Furthermore, its effect on the ellipticity of the interference pattern with the tilt angle of the sample pool is analyzed. The relative error of the axis ratio for layout I does not exceed 9.2% at different defocus distances. The experimental results have good agreement with the theoretical analyses, and it indicates that layout II is more reasonable for the IPI system.

Influence of sample pool on interference pattern in defocused interferometric particle imaging

NASA Astrophysics Data System (ADS)

Zhang, Hongxia; Zhou, Ye; Liu, Jing; Jia, Dagong; Liu, Tiegen

2017-04-01

Particles widely exist in various fields. In practical experiments, sometimes it is necessary to dissolve particles in water in a sample pool. This article proposes two typical layouts of the sample pool in defocused interferometric particle imaging (IPI). Layout I is the sample pool surface perpendicular to the incident light and layout II is the sample pool surface perpendicular to the scattered light. For layout I, the scattered light of the particles does not keep symmetric at the meridional and sagittal planes after being refracted by the sample pool surface, and elliptical interference patterns are formed at the defocused IPI image plane. But for layout II, the scattered light keeps symmetric after being refracted, and circular interference patterns are formed. Aimed at the two sample pool layouts, the ray-tracing software ZEMAX was used to simulate the spot shape of particles at different defocus distances. Furthermore, its effect on the ellipticity of the interference pattern with the tilt angle of the sample pool is analyzed. The relative error of the axis ratio for layout I does not exceed 9.2% at different defocus distances. The experimental results have good agreement with the theoretical analyses, and it indicates that layout II is more reasonable for the IPI system.

A new methodology for surcharge risk management in urban areas (case study: Gonbad-e-Kavus city).

PubMed

Hooshyaripor, Farhad; Yazdi, Jafar

2017-02-01

This research presents a simulation-optimization model for urban flood mitigation integrating Non-dominated Sorting Genetic Algorithm (NSGA-II) with Storm Water Management Model (SWMM) hydraulic model under a curve number-based hydrologic model of low impact development technologies in Gonbad-e-Kavus, a small city in the north of Iran. In the developed model, the best performance of the system relies on the optimal layout and capacity of retention ponds over the study area in order to reduce surcharge from the manholes underlying a set of storm event loads, while the available investment plays a restricting role. Thus, there is a multi-objective optimization problem with two conflicting objectives solved successfully by NSGA-II to find a set of optimal solutions known as the Pareto front. In order to analyze the results, a new factor, investment priority index (IPI), is defined which shows the risk of surcharging over the network and priority of the mitigation actions. The IPI is calculated using the probability of pond selection for candidate locations and average depth of the ponds in all Pareto front solutions. The IPI can help the decision makers to arrange a long-term progressive plan with the priority of high-risk areas when an optimal solution has been selected.

The Arctic Observing Network (AON)Cooperative Arctic Data and Information Service (CADIS)

NASA Astrophysics Data System (ADS)

Moore, J.; Fetterer, F.; Middleton, D.; Ramamurthy, M.; Barry, R.

2007-12-01

The Arctic Observing Network (AON) is intended to be a federation of 34 land, atmosphere and ocean observation sites, some already operating and some newly funded by the U.S. National Science Foundation. This International Polar Year (IPY) initiative will acquire a major portion of the data coming from the interagency Study of Environmental Arctic Change (SEARCH). AON will succeed in supporting the science envisioned by its planners only if it functions as a system and not as a collection of independent observation programs. Development and implementation of a comprehensive data management strategy will key a key to the success of this effort. AON planners envision an ideal data management system that includes a portal through which scientists can submit metadata and datasets at a single location; search the complete archive and find all data relevant to a location or process; all data have browse imagery and complete documentation; time series or fields can be plotted on line, and all data are in a relational database so that multiple data sets and sources can be queried and retrieved. The Cooperative Arctic Data and Information Service (CADIS) will provide near-real-time data delivery, a long-term repository for data, a portal for data discovery, and tools to manipulate data by building on existing tools like the Unidata Integrated Data Viewer (IDV). Our approach to the data integration challenge is to start by asking investigators to provide metadata via a general purpose user interface. An entry tool assists PIs in writing metadata and submitting data. Data can be submitted to the archive in NetCDF with Climate and Forecast conventions or in one of several other standard formats where possible. CADIS is a joint effort of the University Corporation for Atmospheric Research (UCAR), the National Snow and Ice Data Center (NSIDC), and the National Center for Atmospheric Research (NCAR). In the first year, we are concentrating on establishing metadata protocols that are compatible with international standards, and on demonstrating data submission, search and visualization tools with a subset of AON data. These capabilities will be expanded in years 2 and 3. By working with AON investigators and by using evolving conventions for in situ data formats as they mature, we hope to bring CADIS to the full level of data integration imagined by AON planners. The CADIS development will be described in terms of challenges, implementation strategies and progress to date. The developers are making a conscious effort to integrate this system and its data holdings with the complementary efforts in the SEARCH and IPY programs. The interdisciplinary content of the data, the variations in format and documentation, as well as its geographic coverage across the Arctic Basin all impact the form and effectiveness of the CADIS system architecture. The clever solutions to the complexity of implementing a comprehensive data management strategy implied in this diversity will be a focus of the presentation.

Sequential healing at implants installed immediately into extraction sockets. An experimental study in dogs.

PubMed

Mainetti, Tomaso; Lang, Niklaus P; Bengazi, Franco; Favero, Vittorio; Soto Cantero, Luis; Botticelli, Daniele

2016-01-01

To compare the sequential healing at implants installed in a healed alveolar bony ridge or immediately after tooth extraction without functional load. In the mandible of 12 dogs, the mesial roots of the first molars were endodontically treated, the tooth hemisected, and the distal roots extracted. After 3 months, the mesial roots of the fourth premolars were endodontically treated, the tooth hemisected, and the distal roots extracted in one side of the mandible. Implants were placed immediately into extraction sockets (IPIES) of the fourth premolar and in the healed sites in the molar regions. Healing abutments were placed, and the flaps were sutured to allow a non-submerged healing. The time of surgery and of sacrifices were planned in such a way to obtain biopsies representing the healing after 1 and 2 weeks and 1 and 3 months, respectively. Ground sections were prepared for histological evaluation of tissues components on the implant surface and the coronal termination level of osseointegration (M-B). New bone apposition on the implant surface was slightly higher at the healed compared to the IPIES sites, being 7.4% and 4.1% after 1 week, and 67.3% and 65.3% after 3 months, respectively. Old bone was progressively resorbed, from 27.0% and 21.9% after 1 week, to 2.5% and 2.0% after 3 months, at healed and IPIES sites, respectively. M-B was 1.4 mm and 2.6 mm after 1 week, 1.2 mm and 1.2 mm after 3 months, at healed and IPIES sites, respectively. Similar patterns of sequential osseointegration were found at implants installed in healed alveolar bone or in alveolar sockets immediately after tooth extraction. The coronal termination level of osseointegration, that was different after 1 week, was found similar at the 3-month observation. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

XRCC2 Polymorphisms and Environmental Factors Predict High Risk of Colorectal Cancer.

PubMed

Wang, Lijie; Ma, Junxun; Yang, Bo; Jing, Fangfang; Hu, Yi

2018-05-07

BACKGROUND This case-control study aimed to analyze the association of [i]XRCC2[/i] polymorphisms (rs3218408 and rs3218384) with colorectal cancer (CRC) risk. The interaction of [i]XRCC2[/i] polymorphisms with environmental factors was investigated as well. MATERIAL AND METHODS We enrolled 147 CRC patients and 114 healthy individuals into the study. Polymerase chain reaction (PCR)-sequencing method was performed to detect rs3218408 and rs3218384 polymorphisms. Hardy-Weinberg equilibrium (HWE) was checked in the control group. Odds ratio (OR) with 95% confidence interval (CI) represented the risk of CRC. Cross-table method was used in analyzing the interaction effects. RESULTS Compared to the control group, the frequency of smokers was much higher in the case group ([i]P[/i]<0.001). A similar result was observed in drinkers (55.8% [i]vs.[/i] 40.4%, [i]P[/i]=0.013). Dietary habits of all subjects were investigated as well, showing that CRC patients ate fewer vegetables than did healthy controls (P<0.001). In the analysis of polymorphisms, rs3218408 appeared to be an independent risk factor of CRC (GG: OR=2.048, 95%CI=1.032-4.061; G allele: OR=1.445, 95%CI=1.019-2.049). There were 68 (76.4%) C allele carriers (rs3218384) among smokers, which was higher than the number of G allele carriers ([i]P[/i]<0.001). A similar outcome was observed for alcohol drinkers ([i]P[/i]=0.048), which suggests a relationship of rs3218384 with smoking and drinking. Further analysis indicated that interaction of rs3218384 with smoking increased the risk of CRC (GG and smoking: OR=3.250, 95%CI=1.235-8.556; GC+CC and smoking: OR=2.167, 95%CI=1.175-3.996). CONCLUSIONS We found that rs3218408 was related with increased risk of CRC, and the interaction of rs3218384 with smoking increased the risk of CRC.

Intrapleural fluid infusion for MR-guided high-intensity focused ultrasound ablation in the liver dome.

PubMed

Wijlemans, Joost W; de Greef, Martijn; Schubert, Gerald; Moonen, Chrit T W; van den Bosch, Maurice A A J; Ries, Mario

2014-12-01

Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) ablation of tumors in the liver dome is challenging because of the presence of air in the costophrenic angle. In this study, we used a porcine liver model and a clinical MR-HIFU system to assess the feasibility and safety of using intrapleural fluid infusion (IPI) to create an acoustic window for MR-HIFU ablation in the liver dome. Healthy adult Dalland land pigs (n = 6) under general anesthesia were used with animal committee approval. Degassed saline (200-800 mL) was infused into the intrapleural space under ultrasound guidance. A clinical 1.5-T MR-HIFU system was used to perform sonications (4-mm treatment cells, 300-450 W, 20-30 seconds) in the liver dome under real-time MR thermometry. An intercostal firing technique was used to prevent rib heating in one experiment. Technical success was defined as a temperature increase (>10°C) in the target area. After termination, the animal was examined for thermal damage to liver, diaphragm, pleura, lung, or intercostal muscle. An acoustic window was established in all animals. A temperature increase in the target area was achieved in all animals (max. 47°C-67°C). MR thermometry showed no heating outside the target area. Intercostal firing effectively reduced rib heating (55°C vs. 42°C). Postmortem examination revealed no unwanted thermal damage. One complication occurred, in the first experiment, because of an ill-suited needle (displacement of the needle). The results indicate that IPI may be used safely to assist MR-HIFU ablation of tumors in the liver dome. For reliable tissue coagulation, IPI must be combined with an intercostal sonication technique. Considering the proportion of patients with tumors in the liver dome, IPI widens the applicability of MR-HIFU ablation for liver tumors considerably. Copyright © 2014 AUR. Published by Elsevier Inc. All rights reserved.

Size Distribution of Sperm Whales Acoustically Identified during Long Term Deep-Sea Monitoring in the Ionian Sea

PubMed Central

Caruso, Francesco; Sciacca, Virginia; Bellia, Giorgio; De Domenico, Emilio; Larosa, Giuseppina; Papale, Elena; Pellegrino, Carmelo; Pulvirenti, Sara; Riccobene, Giorgio; Simeone, Francesco; Speziale, Fabrizio; Viola, Salvatore; Pavan, Gianni

2015-01-01

The sperm whale (Physeter macrocephalus) emits a typical short acoustic signal, defined as a “click”, almost continuously while diving. It is produced in different time patterns to acoustically explore the environment and communicate with conspecifics. Each emitted click has a multi-pulse structure, resulting from the production of the sound within the sperm whale’s head. A Stable Inter Pulse Interval (Stable IPI) can be identified among the pulses that compose a single click. Applying specific algorithms, the measurement of this interval provides useful information to assess the total length of the animal recorded. In January 2005, a cabled hydrophone array was deployed at a depth of 2,100 m in the Central Mediterranean Sea, 25 km offshore Catania (Ionian Sea). The acoustic antenna, named OνDE (Ocean noise Detection Experiment), was in operation until November 2006. OνDE provided real time acoustic data used to perform Passive Acoustic Monitoring (PAM) of cetacean sound emissions. In this work, an innovative approach was applied to automatically measure the Stable IPI of the clicks, performing a cepstrum analysis to the energy (square amplitude) of the signals. About 2,100 five-minute recordings were processed to study the size distribution of the sperm whales detected during the OνDE long term deep-sea acoustic monitoring. Stable IPIs were measured in the range between 2.1 ms and 6.4 ms. The equations of Gordon (1991) and of Growcott (2011) were used to convert the IPIs into measures of size. The results revealed that the sperm whales recorded were distributed in length from about 7.5 m to 14 m. The size category most represented was from 9 m to 12 m (adult females or juvenile males) and specimens longer than 14 m (old males) seemed to be absent. PMID:26675588

Blunted Day-Night Changes in Luteinizing Hormone Pulse Frequency in Girls With Obesity: the Potential Role of Hyperandrogenemia

PubMed Central

Collins, Jessicah S.; Beller, Jennifer P.; Burt Solorzano, Christine; Patrie, James T.; Chang, R. Jeffrey; Marshall, John C.

2014-01-01

Context: Puberty is marked by sleep-associated changes in LH pulse frequency and amplitude. Early pubertal girls with obesity exhibit blunted day-to-night changes in LH secretion; whether this occurs in late pubertal obese girls is unknown. Objective: The objective of the study was to test two hypotheses: 1) blunted day-to-night changes in LH secretion occur in both early and late pubertal obese girls, and 2) such alterations are specifically associated with hyperandrogenemia. Design: This was a cross-sectional analysis. Setting: The study was conducted at a clinical research center. Patients or Other Participants: Twenty-seven early pubertal, premenarcheal girls (12 of whom were obese) and 63 late pubertal (postmenarcheal) girls (27 of whom were obese) participated in the study. Intervention: Blood samples were taken every 10 minutes from 7:00 pm to 7:00 am. Main Outcome Measure: Change in LH pulse frequency [LH interpulse interval (IPI)] from daytime hours (7:00 pm-11:00 pm, while awake) to nighttime hours (11:00 pm to 7:00 am, while generally asleep). Results: Both nonobese and obese postmenarcheal girls demonstrated significant day-to-night decreases in LH pulse frequency (IPI increases of 33% and 16%, respectively), but day-to-night changes were blunted in obese girls (P = .004, obese vs nonobese). Day-to-night LH pulse frequency decreased significantly in postmenarcheal obese subjects with normal T concentrations (26% IPI increase) but not in those with hyperandrogenemia. Similar differences were evident for LH pulse amplitude. Nonobese and obese early pubertal girls exhibited nonsignificant differences in day-night LH pulse frequency (day to night IPI increase of 26% vs decrease of 1%, respectively). Conclusions: Day-to-night changes in LH pulse secretion are blunted in postmenarcheal obese adolescent girls. This phenomenon may in part reflect hyperandrogenemia. PMID:24780043

The Effect of Intestinal Parasitic Infection on the Clinical Outcome of Malaria in Coinfected Children in Cameroon

PubMed Central

Kwenti, Tebit E.; Nkume, Franklin A.; Tanjeko, Ajime T.; Kwenti, Tayong D. B.

2016-01-01

Background The interaction between intestinal parasites and malaria is still not clear. Data in published literature are conflicting. We studied the effect of intestinal parasitic infection (IPI) on the clinical outcome of malaria in coinfected children. Methods In a cross sectional study performed between October 2014 and September 2015, children infected with malaria, as demonstrated by the presence of asexual parasites in Giemsa stained blood films, were enrolled. Stool samples were obtained from participants and subjected to the formol-ether concentration technique for the detection of intestinal parasites. The Complete blood count was performed using an automated haematology analyser (Mindray, BC-2800). The risk ratio, Pearson’s chi-square and the student T test were all performed as part of the statistical analyses. Statistical significance was set at p < 0.05. Results In all, 405 children successfully took part in the study. The children were between 1 week and 120 months of age (mean ± SD = 41.5 ± 33.5). Coinfection with intestinal parasites was observed in 11.6%. The rate of severe malaria (SM) attack in this study was 10.9%. SM was not observed to be associated with age (p = 0.377) or gender (p = 0.387), meanwhile coinfection with intestinal parasites was associated with age (p = 0.003). Among SM cases, IPI prevalence was higher in children with mild (WHO group 3) severe malaria (p = 0.027). Overall, IPI was not observed to be associated with SM (p = 0.656) or malaria parasite density (p = 0.185) or haemoglobin concentration (p = 0.205). The main clinical features of SM observed were hyperpyrexia (68.2%), severe malarial anaemia (61.4%), and multiple convulsion (52.3%). Conclusion IPI was not observed to be associated with the severity of malaria, the malaria parasite density, and the haemoglobin concentration in coinfected children in Cameroon. The clinical outcome of malaria in children coinfected with intestinal parasites may depend on the geographical setting after all. PMID:27128975

The Effect of Intestinal Parasitic Infection on the Clinical Outcome of Malaria in Coinfected Children in Cameroon.

PubMed

Kwenti, Tebit E; Nkume, Franklin A; Tanjeko, Ajime T; Kwenti, Tayong D B

2016-04-01

The interaction between intestinal parasites and malaria is still not clear. Data in published literature are conflicting. We studied the effect of intestinal parasitic infection (IPI) on the clinical outcome of malaria in coinfected children. In a cross sectional study performed between October 2014 and September 2015, children infected with malaria, as demonstrated by the presence of asexual parasites in Giemsa stained blood films, were enrolled. Stool samples were obtained from participants and subjected to the formol-ether concentration technique for the detection of intestinal parasites. The Complete blood count was performed using an automated haematology analyser (Mindray, BC-2800). The risk ratio, Pearson's chi-square and the student T test were all performed as part of the statistical analyses. Statistical significance was set at p < 0.05. In all, 405 children successfully took part in the study. The children were between 1 week and 120 months of age (mean ± SD = 41.5 ± 33.5). Coinfection with intestinal parasites was observed in 11.6%. The rate of severe malaria (SM) attack in this study was 10.9%. SM was not observed to be associated with age (p = 0.377) or gender (p = 0.387), meanwhile coinfection with intestinal parasites was associated with age (p = 0.003). Among SM cases, IPI prevalence was higher in children with mild (WHO group 3) severe malaria (p = 0.027). Overall, IPI was not observed to be associated with SM (p = 0.656) or malaria parasite density (p = 0.185) or haemoglobin concentration (p = 0.205). The main clinical features of SM observed were hyperpyrexia (68.2%), severe malarial anaemia (61.4%), and multiple convulsion (52.3%). IPI was not observed to be associated with the severity of malaria, the malaria parasite density, and the haemoglobin concentration in coinfected children in Cameroon. The clinical outcome of malaria in children coinfected with intestinal parasites may depend on the geographical setting after all.

Prognostic Significance of Diffuse Large B-Cell Lymphoma Cell of Origin Determined by Digital Gene Expression in Formalin-Fixed Paraffin-Embedded Tissue Biopsies

PubMed Central

Scott, David W.; Mottok, Anja; Ennishi, Daisuke; Wright, George W.; Farinha, Pedro; Ben-Neriah, Susana; Kridel, Robert; Barry, Garrett S.; Hother, Christoffer; Abrisqueta, Pau; Boyle, Merrill; Meissner, Barbara; Telenius, Adele; Savage, Kerry J.; Sehn, Laurie H.; Slack, Graham W.; Steidl, Christian; Staudt, Louis M.; Connors, Joseph M.; Rimsza, Lisa M.; Gascoyne, Randy D.

2015-01-01

Purpose To evaluate the prognostic impact of cell-of-origin (COO) subgroups, assigned using the recently described gene expression–based Lymph2Cx assay in comparison with International Prognostic Index (IPI) score and MYC/BCL2 coexpression status (dual expressers). Patients and Methods Reproducibility of COO assignment using the Lymph2Cx assay was tested employing repeated sampling within tumor biopsies and changes in reagent lots. The assay was then applied to pretreatment formalin-fixed paraffin-embedded tissue (FFPET) biopsies from 344 patients with de novo diffuse large B-cell lymphoma (DLBCL) uniformly treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) at the British Columbia Cancer Agency. MYC and BCL2 protein expression was assessed using immunohistochemistry on tissue microarrays. Results The Lymph2Cx assay provided concordant COO calls in 96% of 49 repeatedly sampled tumor biopsies and in 100% of 83 FFPET biopsies tested across reagent lots. Critically, no frank misclassification (activated B-cell–like DLBCL to germinal center B-cell–like DLBCL or vice versa) was observed. Patients with activated B-cell–like DLBCL had significantly inferior outcomes compared with patients with germinal center B-cell–like DLBCL (log-rank P < .001 for time to progression, progression-free survival, disease-specific survival, and overall survival). In pairwise multivariable analyses, COO was associated with outcomes independent of IPI score and MYC/BCL2 immunohistochemistry. The prognostic significance of COO was particularly evident in patients with intermediate IPI scores and the non–MYC-positive/BCL2-positive subgroup (log-rank P < .001 for time to progression). Conclusion Assignment of DLBCL COO by the Lymph2Cx assay using FFPET biopsies identifies patient groups with significantly different outcomes after R-CHOP, independent of IPI score and MYC/BCL2 dual expression. PMID:26240231

IGY to IPY, the U.S. Antarctic oversnow and airborne geophysical-glaciological research program from 1957 to 1964 from the view of a young graduate student

USGS Publications Warehouse

Behrendt, John C.

2007-01-01

When 12 countries established scientific stations in Antarctica for the 1957-58 (IGY), the Cold War was at its height, seven countries had made claims in Antarctica, and the Antarctic Treaty was in the future. The only major field project of the U.S. IGY Antarctic program was series of oversnow traverses, starting in 1957, making seismic reflection ice soundings (and other geophysical measurements) and glaciological studies. The U.S.S.R. and France made similar traverses coordinated through the IGY. Although geology and topographic mapping were not part of the IGY program because of the claims issue and the possibility of mineral resources, the oversnow traverse parties did geologic work, during which unknown mountains were discovered. The oversnow traverses continued through 1966 and resulted in an excellent first approximation of the snow surface elevation, ice thickness and bed topography of Antarctica, as well as the mean annual temperature of that era and snow accumulation.

Delay in initiation of treatment after diagnosis of pulmonary tuberculosis in primary health care setting: eight year cohort analysis from district Faridabad, Haryana, North India.

PubMed

Kant, Shashi; Singh, Arvind K; Parmeshwaran, Giridara G; Haldar, Partha; Malhotra, Sumit; Kaur, Ravneet

2017-01-01

Delay in initiation of tuberculosis (TB) treatment may have a tremendous impact on disease transmission, development of drug resistance, poor outcome and overall survival of TB patients. The delay can occur at various levels. Delay in initiation of treatment after diagnosis is mostly due to health system failure and has immense programmatic implications. It has not been studied extensively in the Indian setting. The authors did a cohort analysis of all TB patients initiated on treatment from two primary health centres (PHCs) at Ballabgarh Health and Demographic Surveillance System between January 2007 and December 2014. Diagnosis and treatment of TB in the study area was done as per the protocol envisaged in the national program. Information related to demography, details of diagnosis and treatment of TB and outcome of treatment were extracted from the TB register. Delay in initiation of treatment after diagnosis was considered if the gap between diagnosis and treatment was greater than 7 days. Bivariate and multivariate analyses were done to find the association of various factors with delay in initiation of treatment after diagnosis. Out of 885 patients, 662 patients started treatment for pulmonary TB. Mean time interval between diagnosis and initiation of treatment was 8.95 days. Only 57.7% of pulmonary TB patients were started on treatment within 7 days of diagnosis, and an additional 24.5% were started on treatment 8-14 days after diagnosis. Patients on retreatment regimens and those residing in villages without a PHC were more likely to have delayed initiation of treatment (odds ratio (OR)=1.82 (1.3-2.7, p=0.001) and OR=1.62 (1.1-2.5, p=0.01) respectively). Delay in initiation of treatment was also associated with unfavourable treatment outcome such as default, failure or death. There is a need to have healthcare changes related to TB care to enable initiation of treatment as early as possible. Pretreatment counselling especially for retreatment patients is of utmost importance.

Exploring Earth's Polar Regions Online at Windows to the Universe

NASA Astrophysics Data System (ADS)

Gardiner, L.; Johnson, R.; Russell, R.; Genyuk, J.; Bergman, J.; Lagrave, M.

2007-12-01

Earth's Polar Regions (www.windows.ucar.edu/polar.html), a new section of the Windows to the Universe Web site, made its debut in March 2007, at the start of International Polar Year. With this new online resource we seek to communicate information about the science, the history and cultures of the Arctic and Antarctic to students, teachers, and the general public. The Web section includes brief articles about diverse aspects of the science of polar regions including the cryosphere, climate change, geography, oceans, magnetic poles, the atmosphere, and ecology. Polar science topics link to related areas of the broader Web site as well. Other articles tell the stories of our human connections to the polar regions including the history of polar exploration and human cultures. Online "Postcards from the Field" allow contributing scientists to share their polar research with a broader audience. We continue to build content, games, puzzles, and interactives to complement and expand the existing resources. A new section about the poles of other planets is also in development. A growing collection of classroom activities which allow students to explore aspects of the polar regions is provided for K-12 educators. An image gallery of photographs from the polar regions and links to IPY and related educational programs provide additional resources for educators. We have been disseminating information about the Earth's Polar Regions Web resources to educators via National Science Teacher Association workshops, the Windows to the Universe educator newsletter, various education Listservs, and Climate Discovery courses offered through NCAR Online Education. Windows to the Universe (www.windows.ucar.edu), a long-standing and widely-used Web resource (with over 20 million user sessions in the past 12 months), provides extensive information about the Earth and space sciences at three levels - beginner, intermediate, and advanced - to serve the needs of upper elementary through lower undergraduate students as well as the general public. These resources are available in both English and Spanish. Funding for polar content development is provided by the National Center for Atmospheric Research, the National Science Foundation, and NASA IPY.

McMurdo Dry Valleys, Antarctica - A Mars Phoenix Mission Analog

NASA Technical Reports Server (NTRS)

Tamppari, L. K.; Anderson, R. M.; Archer, D.; Douglas, S.; Kounaves, S. P.; McKay, C. P.; Ming, Douglas W.; Moore, Q.; Quinn, J. E.; Smith, P. H.;

IPY Education, Outreach and Communication - Some Lessons Learned (Invited)

NASA Astrophysics Data System (ADS)

Carlson, D. J.; Salmon, R.; Munro, N.

2009-12-01

IPY Education, Outreach and Communications planning and implementation occurred with a minimum of staff and resources and a maximum of international volunteer enthusiasm and energy. Although many relatively well-funded and remarkable national activities occurred, sharing and promoting these internationally depended entirely on the volunteer networks of individuals and institutions. Through these partnerships we have learned valuable lessons about impact and distribution, and challenged several assumptions about educational partnerships. For example, we learned the importance of regular pre-scheduled events, and how to use networks of volunteer translators and free geobrowser tools. We have learned how best to conduct planning meetings and live events across time zones and hemispheres, and shown how the best concepts and ideas of science education can propagate across age groups and among languages. We have learned the optimal times of year for international events, and the most effective means for international distribution and communication. We have established a rapid-response help desk without home or staff, and sustained active and high-impact interactions with journalists largely without press releases. We have shown that, in general, wide-spread distribution of freely accessible materials produces a better impact than embargoes and restrictions. Most fundamentally, we have exposed a pervasive interest in polar science and a hunger for climate information, and responded with an active, flexible, and efficient network of partners and products.

Prognostic value of tumor necrosis at CT in diffuse large B-cell lymphoma.

PubMed

Adams, Hugo J A; de Klerk, John M H; Fijnheer, Rob; Dubois, Stefan V; Nievelstein, Rutger A J; Kwee, Thomas C

2015-03-01

To determine the prognostic value of tumor necrosis at computed tomography (CT) in newly diagnosed diffuse large B-cell lymphoma (DLBCL). This retrospective study included 51 patients with newly diagnosed DLBCL who had undergone both unenhanced and intravenous contrast-enhanced CT before R-CHOP (rituximab, cyclophosphamide, hydroxydaunorubicin, oncovin and prednisolone) chemo-immunotherapy. Presence of tumor necrosis was visually and quantitatively assessed at CT. Associations between tumor necrosis status at CT and the National Comprehensive Cancer Network (NCCN) International Prognostic Index (IPI) factors were assessed. Cox regression analysis was used to determine the prognostic impact of NCCN-IPI scores and tumor necrosis status at CT. There were no correlations between tumor necrosis status at CT and the NCCN-IPI factors categorized age (ρ=-0.042, P=0.765), categorized lactate dehydrogenase (LDH) ratio (ρ=0.201, P=0.156), extranodal disease in major organs (φ=-0.245, P=0.083), Ann Arbor stage III/IV disease (φ=-0.208, P=0.141), and Eastern Cooperative Oncology Group (ECOG) performance status (φ=0.015, P=0.914). In the multivariate Cox proportional hazards model, only tumor necrosis status at CT was an independent predictive factor of progression-free survival (P=0.003) and overall survival (P=0.004). The findings of this study indicate the prognostic potential of tumor necrosis at CT in newly diagnosed DLBCL. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Prognostic significance of peripheral monocyte count in patients with extranodal natural killer/T-cell lymphoma.

PubMed

Huang, Jia-Jia; Li, Ya-Jun; Xia, Yi; Wang, Yu; Wei, Wen-Xiao; Zhu, Ying-Jie; Lin, Tong-Yu; Huang, Hui-Qiang; Jiang, Wen-Qi; Li, Zhi-Ming

2013-05-03

Extranodal natural killer/T-cell lymphoma (ENKL) has heterogeneous clinical manifestations and prognosis. This study aims to evaluate the prognostic impact of absolute monocyte count (AMC) in ENKL, and provide some immunologically relevant information for better risk stratification in patients with ENKL. Retrospective data from 163 patients newly diagnosed with ENKL were analyzed. The absolute monocyte count (AMC) at diagnosis was analyzed as continuous and dichotomized variables. Independent prognostic factors of survival were determined by Cox regression analysis. The AMC at diagnosis were related to overall survival (OS) and progression-free survival (PFS) in patients with ENKL. Multivariate analysis identified AMC as independent prognostic factors of survival, independent of International Prognostic Index (IPI) and Korean prognostic index (KPI). The prognostic index incorporating AMC and absolute lymphocyte count (ALC), another surrogate factor of immune status, could be used to stratify all 163 patients with ENKL into different prognostic groups. For patients who received chemotherapy followed by radiotherapy (102 cases), the three AMC/ALC index categories identified patients with significantly different survivals. When superimposed on IPI or KPI categories, the AMC/ALC index was better able to identify high-risk patients in the low-risk IPI or KPI category. The baseline peripheral monocyte count is shown to be an effective prognostic indicator of survival in ENKL patients. The prognostic index related to tumor microenvironment might be helpful to identify high-risk patients with ENKL.

Integral reinforcement learning for continuous-time input-affine nonlinear systems with simultaneous invariant explorations.

PubMed

Lee, Jae Young; Park, Jin Bae; Choi, Yoon Ho

2015-05-01

This paper focuses on a class of reinforcement learning (RL) algorithms, named integral RL (I-RL), that solve continuous-time (CT) nonlinear optimal control problems with input-affine system dynamics. First, we extend the concepts of exploration, integral temporal difference, and invariant admissibility to the target CT nonlinear system that is governed by a control policy plus a probing signal called an exploration. Then, we show input-to-state stability (ISS) and invariant admissibility of the closed-loop systems with the policies generated by integral policy iteration (I-PI) or invariantly admissible PI (IA-PI) method. Based on these, three online I-RL algorithms named explorized I-PI and integral Q -learning I, II are proposed, all of which generate the same convergent sequences as I-PI and IA-PI under the required excitation condition on the exploration. All the proposed methods are partially or completely model free, and can simultaneously explore the state space in a stable manner during the online learning processes. ISS, invariant admissibility, and convergence properties of the proposed methods are also investigated, and related with these, we show the design principles of the exploration for safe learning. Neural-network-based implementation methods for the proposed schemes are also presented in this paper. Finally, several numerical simulations are carried out to verify the effectiveness of the proposed methods.

ISO/IEC's image interchange facility

NASA Astrophysics Data System (ADS)

Blum, Christof; Hofmann, Georg R.

1992-04-01

This paper gives a technical description of the Image Interchange Facility (IIF), which comprises both a formate definition and a functional gateway specification. IIF is a part of the first International Image Processing and Interchange Standard (IPI), which is under elaboration by ISO/IEC JTC1/SC24. This paper reflects the related committee work performed up until January 1992. Considering the deficiencies and drawbacks of existing formats and current practices in exchanging digital images, the need for a new and more general approach to image interchange can be seen. This paper describes the requirements and design principles of the IIF data format and the IIF gateway. Furthermore, it explains the relation to the reference model for open communication (OSI) as well as the relation to the other parts of the IPI standard.

Exploiting cancer cell vulnerabilities to develop a combination therapy for Ras-driven tumors

PubMed Central

De Raedt, Thomas; Walton, Zandra; Yecies, Jessica L.; Li, Danan; Chen, Yimei; Malone, Clare F.; Maertens, Ophelia; Jeong, Seung Min; Bronson, Roderick T.; Lebleu, Valerie; Kalluri, Raghu; Normant, Emmanuel; Haigis, Marcia C.; Manning, Brendan D.; Wong, Kwok-Kin; Macleod, Kay F; Cichowski, Karen

2011-01-01

Summary Ras-driven tumors are often refractory to conventional therapies. Here we identify a promising targeted therapeutic strategy for two Ras-driven cancers: Nf1-deficient malignancies and KRas/p53-mutant lung cancer. We show that agents that enhance proteotoxic stress, including the HSP90 inhibitor IPI-504, induce tumor regression in aggressive mouse models, but only when combined with rapamycin. These agents synergize by promoting irresolvable ER stress, resulting in catastrophic ER and mitochondrial damage. This process is fueled by oxidative stress, which is caused by IPI-504-dependent production of reactive oxygen species, and the rapamycin-dependent suppression of glutathione, an important endogenous antioxidant. Notably, the mechanism by which these agents cooperate reveals a therapeutic paradigm that can be expanded to develop additional combinations. PMID:21907929

Experimental animal studies of radon and cigarette smoke

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cross, F.T.; Dagle, G.E.; Gies, R.A.

Cigarette-smoking is a dominant cause of lung cancer and confounds risk assessment of exposure to radon decay products. Evidence in humans on the interaction between cigarette-smoking and exposure to radon decay products, although limited, indicates a possible synergy. Experimental animal data, in addition to showing synergy, also show a decrease or no change in risk with added cigarette-smoke exposures. This article reviews previous animal data developed at Compagnie Generale des Matieres Nucleaires and Pacific Northwest Laboratory (PNL) on mixed exposures to radon and cigarette smoke, and highlights new initiation-promotion-initiation (IPI) studies at PNL that were designed within the framework ofmore » a two-mutation carcinogenesis model. Also presented are the PNL exposure system, experimental protocols, dosimetry, and biological data observed to date in IPI animals.« less

Use of First-phase Insulin Secretion in Early Diagnosis of Thyroid Diabetes and Type 2 Diabetes Mellitus

PubMed Central

Meng, Li-Heng; Huang, Yao; Zhou, Jia; Liang, Xing-Huan; Xian, Jing; Li, Li; Qin, Ying-Fen

2017-01-01

Background: A relationship between hyperthyroidism and insulin secretion in type 2 diabetes mellitus (T2DM) has been reported. Therefore, this study explored the use of first-phase insulin secretion in the differential diagnosis of thyroid diabetes (TDM) and T2DM. Methods: In total, 101 patients with hyperthyroidism were divided into hyperthyroidism with normal glucose tolerance (TNGT), hyperthyroidism with impaired glucose regulation (TIGR), and diabetes (TDM) groups. Furthermore, 96 patients without hyperthyroidism were recruited as control groups (normal glucose tolerance [NGT], impaired glucose regulation [IGR], and T2DM). The following parameters were evaluated: homeostasis model assessment (HOMA)-IR, HOMA-β, modified β-cell function index (MBCI), peak insulin/fasting insulin (IP/I0), AUCins-OGTT, and AUCins-OGTT/AUCglu-OGTT from the oral glucose tolerance test (OGTT) insulin release test were utilized to assess the second-phase insulin secretion, while the IP/I0, AIR0′~10′, and AUCins-IVGTT from the intravenous glucose tolerance test (IVGTT) insulin release test were used to assess the first-phase insulin secretion. Results: In the OGTT, the HOMA-β values of the TNGT and TDM groups were higher than those of the NGT and T2DM groups (all P < 0.05). In the hyperthyroidism groups, the MBCI of the TDM group was lower than that of the TNGT and TIGR groups (all P < 0.05). Among the control groups, the MBCI values of the IGR and T2DM groups were lower than that of the normal glucose tolerance (NGT) group (all P < 0.05). In the IVGTT, insulin secretion peaked for all groups at 2–4 min, except for the T2DM group, which showed a low plateau and no secretion peak. The IP values of the TNGT, TIGR, and TDM groups were higher than those of the NGT, IGR, and T2DM groups (all P < 0.05). The Ip/I0, AIR0′~10′, and AUCins-IVGTT values of the TDM group were higher than those of the T2DM group but were lower than those of the TNGT, TIGR, NGR, and IGR groups (all P < 0.05). Compared with the other five groups, the Ip/I0, AIR0′~10′, and AUCins-IVGTT values of the T2DM group were significantly decreased (all P < 0.05). The Ip/I0 and AUCins-IVGTT values of the TNGT group were higher than those of the NGT group (all P < 0.05). Conclusions: β-cell function in TDM patients is superior to that in T2DM patients. First-phase insulin secretion could be used as an early diagnostic marker to differentiate TDM and T2DM. PMID:28345543

The Arctic Grand Challenge: Abrupt Climate Change

NASA Astrophysics Data System (ADS)

Wilkniss, P. E.

2003-12-01

Trouble in polar paradise (Science, 08/30/02), significant changes in the Arctic environment are scientifically documented (R.E. Moritz et al. ibid.). More trouble, lots more, "abrupt climate change," (R. B. Alley, et al. Science 03/28/03). R. Corell, Arctic Climate Impact Assessment team (ACIA), "If you want to see what will happen in the rest of the world 25 years from now just look what's happening in the Arctic," (Arctic Council meeting, Iceland, 08/03). What to do? Make abrupt Arctic climate change a grand challenge for the IPY-4 and beyond! Scientifically:Describe the "state" of the Arctic climate system as succinctly as possible and accept it as the point of departure.Develop a hypothesis and criteria what constitutes "abrupt climate change," in the Arctic that can be tested with observations. Observations: Bring to bear existing observations and coordinate new investments in observations through an IPY-4 scientific management committee. Make the new Barrow, Alaska, Global Climate Change Research Facility a major U.S. contribution and focal point for the IPY-4 in the U.S Arctic. Arctic populations, Native peoples: The people of the North are living already, daily, with wrenching change, encroaching on their habitats and cultures. For them "the earth is faster now," (I. Krupnik and D. Jolly, ARCUS, 2002). From a political, economic, social and entirely realistic perspective, an Arctic grand challenge without the total integration of the Native peoples in this effort cannot succeed. Therefore: Communications must be established, and the respective Native entities must be approached with the determination to create well founded, well functioning, enduring partnerships. In the U.S. Arctic, Barrow with its long history of involvement and active support of science and with the new global climate change research facility should be the focal point of choice Private industry: Resource extraction in the Arctic followed by oil and gas consumption, return the combustion products as greenhouse gases to their regions of origin. Thus multinational company operations are affected by their own activities. There is a strong, convincing case, that these industrial giants must be involved in Arctic partnerships of the grand challenge. A most instructive, very successful example is the collaboration by the chemical companies after the discovery of the polar ozone holes, followed by the replacement of the culprit chlorofluorocarbon compounds. Public relations and involvement/education: The IPY offers a unique opportunity to showcase and drive home, into homes, the seriousness of the issue, Hollywood/Madison Avenue/ NASA style, nothing else will do. Ultimately we need to be mindful that "civilizations are ephemeral compared to species. -What we need is a primer on science, clearly written and unambiguous in its meaning-a primer for anyone interested in the state of the Earth and how to survive and live well on it." (James Lovelock, Science, 08/05/98). - Let's start in the Arctic-NOW.

The hydrogeological conditions in Sahel Hasheesh, Eastern Desert, Eg

NASA Astrophysics Data System (ADS)

Abdalla, Mohamed A.; Mekhemer, Hatem M.; Mabrou, Walid Abdallah

2016-06-01

The groundwater development in Egypt in the present time is of a vital importance than in past few years. A comprehensive plan for new land reclamation projects has been recently established. To achieve these plans new sources of water must be available. This has been done by conducting a number of VES'S where interpreted by a comparison with the existing drilled borehole soil samples. The optimum resistivity model is obtained by matching method using "IPI2Win" Moscow State University 2000 software computer programs for resistivity interpretation. The results of the quantitative interpretation of the resistivity curves has been represented as geoelectric sections, showing the thickness and true electric resistivity values of the different geoelectric layers. The results of quantitative interpretation of the vertical electrical soundings show subsurface five geoelectric units and the aquifer system belongs to lower Miocene and the total salinity of 2451.2 ppm. The depth to water surface is 88.05 m and the total dissolved solids are 2451.2 ppm (Mekhemer well). The salt assemblages in Sahel Hasheesh are NaCl, MgCl2, MgSO4, CaSO4, Ca(HCO3)2. This marine water is of brackish sodium chloride water type (NaCl).

The Arctic Research Consortium of the United States (ARCUS)

NASA Astrophysics Data System (ADS)

Wiggins, H. V.; Warnick, W. K.

2008-12-01

The Arctic Research Consortium of the United States (ARCUS) is a nonprofit membership organization composed of universities and institutions that have a substantial commitment to research in the Arctic. ARCUS was formed in 1988 to serve as a forum for planning, facilitating, coordinating, and implementing interdisciplinary studies of the Arctic; to act as a synthesizer and disseminator of scientific information on arctic research; and to educate scientists and the general public about the needs and opportunities for research in the Arctic. ARCUS, in collaboration with the broader science community, relevant agencies and organizations, and other stakeholders, coordinates science planning and educational activities across disciplinary and organizational boundaries. Examples of current ARCUS science planning activities include: serving as the project office for the multi- agency Study of Environmental Arctic Change (SEARCH) program, providing support to the related Bering Ecosystem Study (BEST), and serving as the Science Management Office for the National Science Foundation (NSF) Arctic System Science (ARCSS) Program. ARCUS" central educational activity is PolarTREC (Teachers and Researchers Exploring and Collaborating), an International Polar Year (IPY) program whereby K-12 educators and researchers work together in hands-on field experiences in the Arctic and Antarctic to advance polar science education. Additional science planning, educational, information, and outreach activities include, among many others, the Witness the Arctic newsletter, the Arctic Visiting Speakers" Series, the ArcticInfo listserve, the Internet Media Archive (IMA), and the annual Arctic Forum conference. More information about these and other ARCUS activities can be found at the ARCUS website at: http://www.arcus.org.

The Arctic Research Consortium of the United States

NASA Astrophysics Data System (ADS)

Warnick, W. K.; Wiggins, H. V.

2007-12-01

The Arctic Research Consortium of the United States (ARCUS) is a nonprofit membership organization composed of universities and institutions that have a substantial commitment to research in the Arctic. ARCUS was formed in 1988 to serve as a forum for planning, facilitating, coordinating, and implementing interdisciplinary studies of the Arctic; to act as a synthesizer and disseminator of scientific information on arctic research; and to educate scientists and the general public about the needs and opportunities for research in the Arctic. ARCUS, in collaboration with the broad science community, relevant agencies and organizations, and other stakeholders, coordinates science planning and educational activities across disciplinary and organizational boundaries. Examples of current ARCUS science planning activities include: serving as the project office for the multi-agency Study of Environmental Arctic Change (SEARCH) program and providing support to the related Bering Ecosystem Study (BEST), and serving as the Science Management Office for the National Science Foundation (NSF) Arctic System Science (ARCSS) Program. ARCUS' central educational activity is PolarTREC (Teachers and Researchers Exploring and Collaborating), an International Polar Year (IPY) program whereby K-12 educators and researchers work together in hands-on field experiences in the Arctic and Antarctic to advance polar science education. Additional science planning, educational, information, and outreach activities include the Witness the Arctic newsletter, the Arctic Visiting Speakers' Series, the ArcticInfo listserve, the Internet Media Archive (IMA), the annual Arctic Forum conference, and many others. More information about these and other ARCUS activities can be found at the ARCUS website at www.arcus.org.

The Arctic Research Consortium of the United States (ARCUS)

NASA Astrophysics Data System (ADS)

Creek, K. R.; Fox, S. E.; Wiggins, H. V.

2010-12-01

The Arctic Research Consortium of the United States (ARCUS) is a nonprofit membership organization composed of universities and institutions that have a substantial commitment to research in the Arctic. ARCUS was formed in 1988 to serve as a forum for planning, facilitating, coordinating, and implementing interdisciplinary studies of the Arctic; to act as a synthesizer and disseminator of scientific information on arctic research; and to educate scientists and the general public about the needs and opportunities for research in the Arctic. ARCUS, in collaboration with the broader science community, relevant agencies and organizations, and other stakeholders, coordinates science planning and educational activities across disciplinary and organizational boundaries. Examples of current ARCUS science planning activities include: serving as the project office for the multi-agency Study of Environmental Arctic Change (SEARCH) program, providing support to the related Bering Ecosystem Study (BEST), and serving as the Science Management Office for the National Science Foundation (NSF) Arctic System Science (ARCSS) Program. ARCUS’ central educational activity is PolarTREC (Teachers and Researchers Exploring and Collaborating), an International Polar Year (IPY) program whereby K-12 educators and researchers work together in hands-on field experiences in the Arctic and Antarctic to advance polar science education. Additional science planning, educational, information, and outreach activities include, among many others, the Witness the Arctic newsletter, the Arctic Visiting Speakers’ Series, the ArcticInfo listserve, the Internet Media Archive (IMA), and the annual Arctic Forum conference. More information about these and other ARCUS activities can be found at the ARCUS website at: http://www.arcus.org.

Salvage Regimens With Autologous Transplantation for Relapsed Large B-Cell Lymphoma in the Rituximab Era

PubMed Central

Gisselbrecht, Christian; Glass, Bertram; Mounier, Nicolas; Singh Gill, Devinder; Linch, David C.; Trneny, Marek; Bosly, Andre; Ketterer, Nicolas; Shpilberg, Ofer; Hagberg, Hans; Ma, David; Brière, Josette; Moskowitz, Craig H.; Schmitz, Norbert

2010-01-01

Purpose Salvage chemotherapy followed by high-dose therapy and autologous stem-cell transplantation (ASCT) is the standard treatment for relapsed diffuse large B-cell lymphoma (DLBCL). Salvage regimens have never been compared; their efficacy in the rituximab era is unknown. Patients and Methods Patients with CD20+ DLBCL in first relapse or who were refractory after first-line therapy were randomly assigned to either rituximab, ifosfamide, etoposide, and carboplatin (R-ICE) or rituximab, dexamethasone, high-dose cytarabine, and cisplatin (R-DHAP). Responding patients received high-dose chemotherapy and ASCT. Results The median age of the 396 patients enrolled (R-ICE, n = 202; R-DHAP, n = 194) was 55 years. Similar response rates were observed after three cycles of R-ICE (63.5%; 95% CI, 56% to 70%) and R-DHAP (62.8%; 95 CI, 55% to 69%). Factors affecting response rates (P < .001) were refractory disease/relapse less than versus more than 12 months after diagnosis (46% v 88%, respectively), International Prognostic Index (IPI) of more than 1 versus 0 to 1 (52% v 71%, respectively), and prior rituximab treatment versus no prior rituximab (51% v 83%, respectively). There was no significant difference between R-ICE and R-DHAP for 3-year event-free survival (EFS) or overall survival. Three-year EFS was affected by prior rituximab treatment versus no rituximab (21% v 47%, respectively), relapse less than versus more than 12 months after diagnosis (20% v 45%, respectively), and IPI of 2 to 3 versus 0 to 1 (18% v 40%, respectively). In the Cox model, these parameters were significant (P < .001). Conclusion In patients who experience relapse more than 12 months after diagnosis, prior rituximab treatment does not affect EFS. Patients with early relapses after rituximab-containing first-line therapy have a poor prognosis, with no difference between the effects of R-ICE and R-DHAP. PMID:20660832

Earth Observation taken by STS-117 crewmember on Space Shuttle Atlantis

NASA Image and Video Library

2007-06-10

S117-E-06998 (10 June 2007) --- Polar Mesospheric Clouds are featured in this image photographed by a STS-117 crewmember onboard Space Shuttle Atlantis. Sometimes in the summertime in the far northern (or southern) latitudes, high in the Earth's atmosphere at the edge of space, thin silvery clouds form and are observed just after sunset. These high clouds, occurring at altitudes of about 80 kilometers (50 miles), are called Polar Mesospheric Clouds (PMC) or noctilucent clouds, and are the subject of new studies to determine whether their occurrence is related to global climate change. Observations over the past few years suggest that PMC are now observed more frequently and at lower latitudes than historical observations. Several studies related to the International Polar Year (IPY), and the AIM (Aeronomy of Ice in the Mesosphere) spacecraft are underway to collect relevant data on the chemistry and physics of the mesosphere that might explain the occurrence of PMC. Astronauts in orbiting spacecraft frequently observe PMC over Canada, northern Europe and Asia during June, July and August. While PMC also occur over the high latitudes in the southern hemisphere in December, January and February, astronaut observations of southern PMC are less frequent. Earlier in June 2007, the shuttle crew visiting the International Space Station observed spectacular PMC over north-central Asia. This image was taken looking north while the shuttle and station were docking and flying over the border between western China, Mongolia and Kazakhstan. The red-to-dark region at the bottom of the image is the dense part of the Earth's atmosphere. Because this image was taken with a long lens (180mm), the entire profile of the Earth's limb is not captured. To support IPY research over the next 2 years, station crewmembers will be looking for and documenting PMC in both hemispheres.

Prognostic significance of peripheral monocyte count in patients with extranodal natural killer/T-cell lymphoma

PubMed Central

2013-01-01

Background Extranodal natural killer/T-cell lymphoma (ENKL) has heterogeneous clinical manifestations and prognosis. This study aims to evaluate the prognostic impact of absolute monocyte count (AMC) in ENKL, and provide some immunologically relevant information for better risk stratification in patients with ENKL. Methods Retrospective data from 163 patients newly diagnosed with ENKL were analyzed. The absolute monocyte count (AMC) at diagnosis was analyzed as continuous and dichotomized variables. Independent prognostic factors of survival were determined by Cox regression analysis. Results The AMC at diagnosis were related to overall survival (OS) and progression-free survival (PFS) in patients with ENKL. Multivariate analysis identified AMC as independent prognostic factors of survival, independent of International Prognostic Index (IPI) and Korean prognostic index (KPI). The prognostic index incorporating AMC and absolute lymphocyte count (ALC), another surrogate factor of immune status, could be used to stratify all 163 patients with ENKL into different prognostic groups. For patients who received chemotherapy followed by radiotherapy (102 cases), the three AMC/ALC index categories identified patients with significantly different survivals. When superimposed on IPI or KPI categories, the AMC/ALC index was better able to identify high-risk patients in the low-risk IPI or KPI category. Conclusion The baseline peripheral monocyte count is shown to be an effective prognostic indicator of survival in ENKL patients. The prognostic index related to tumor microenvironment might be helpful to identify high-risk patients with ENKL. PMID:23638998

Characteristics of fin whale vocalizations recorded on instruments in the northeast Pacific Ocean

NASA Astrophysics Data System (ADS)

Weirathmueller, Maria Michelle Josephine

This thesis focuses on fin whale vocalizations recorded on ocean bottom seismometers (OBSs) in the Northeast Pacific Ocean, using data collected between 2003 and 2013. OBSs are a valuable, and largely untapped resource for the passive acoustic monitoring of large baleen whales. This dissertation is divided into three parts, each of which uses the recordings of fin whale vocalizations to better understand their calling behaviors and distributions. The first study describes the development of a technique to extract source levels of fin whale vocalizations from OBS recordings. Source levels were estimated using data collected on a network of eight OBSs in the Northeast Pacific Ocean. The acoustic pressure levels measured at the instruments were adjusted for the propagation path between the calling whales and the instruments using the call location and estimating losses along the acoustic travel path. A total of 1241 calls were used to estimate an average source level of 189 +/-5.8 dB re 1uPa 1m. This variability is largely attributed to uncertainties in the horizontal and vertical position of the fin whale at the time of each call, and the effect of these uncertainties on subsequent calculations. The second study describes a semi-automated method for obtaining horizontal ranges to vocalizing fin whales using the timing and relative amplitude of multipath arrivals. A matched filter is used to detect fin whale calls and pick the relative times and amplitudes of multipath arrivals. Ray-based propagation models are used to predict multipath times and amplitudes as function of range. Because the direct and first multiple arrivals are not always observed, three hypotheses for the paths of the observed arrivals are considered; the solution is the hypothesis and range that optimizes the fit to the data. Ray-theoretical amplitudes are not accurate and solutions are improved by determining amplitudes from the observations using a bootstrap method. Data from ocean bottom seismometers at two locations are used to assess the method: one on the Juan de Fuca Ridge, a bathymetrically complex mid-ocean ridge environment, and the other at a flat sedimented location in the Cascadia Basin. At both sites, the method is reliable up to 4 km range which is sufficient to enable estimates of call density. The third study explores spatial and temporal trends in fin whale calling patterns. The frequency and inter-pulse interval of fin whale 20 Hz vocalizations were observed over 10 years from 2003-2013 on bottom mounted hydrophones and OBSs in the northeast Pacific Ocean. The instrument locations extended from 40°N and 130°W to 125°W with water depths ranging from 1500-4000 m. The inter-pulse interval (IPI) of fin whale song sequences was observed to increase at a rate of 0.59 seconds/year over the decade of observation. During the same time period, peak frequency decreased at a rate of 0.16 Hz/year. Two primary call patterns were observed. During the earlier years, the more commonly observed pattern had a single frequency and single IPI. In later years, a doublet pattern emerged, with two dominant frequencies and two IPIs. Many call sequences in the intervening years appeared to represent a transitional state between the two patterns. The overall trend was consistent across the entire geographical span, although some regional differences exist.

International Year of Planet Earth - Accomplishments, Activities, Challenges and Plans in Mexico

NASA Astrophysics Data System (ADS)

Fucugauchi, J. U.; Perez-Cruz, L. L.; Alaniz-Alvarez, S.

2009-12-01

The International Year of Planet Earth started as a joint initiative by UNESCO and IUGS with the participation of several geosciences organizations, and developed into a major international geosciences program for the triennium 2007-2009, with the inclusion and participation of national and regional committees. In this presentation we focus on current activities and plans in our country and the participation in international activities. Mexican community has been part of international programs since the International Geophysical Year, continuing through its participation in other programs, e.g., Upper Mantle, Geodynamics, Lithosphere, IHY, IPY and eGY. IYPE activities have concentrated in publications, OneGeology, radio/TV programs, organization of conferences, meetings and outreach events. A book series on Earth Science Experiments for Children has been edited, with first books published on “Atmospheric Pressure and Free Fall of Objects”, “Light and Colors”, “Standing on Archimedes”, “Foucault and Climate” and “Earth and its Waves “. Books are distributed to schools, with tens of thousand copies distributed nationwide and new editions underway. Other publications include leaflets, books and special El Faro issues (edited by the National University) and articles in other journals. In 2007 the AGU Joint Assembly with international participation from US, Canada, Europe and Latin America was held in Acapulco. Current plans include an electronic open-access journal, additional publications of the Planet Earth series, articles and special issues in journals and magazines, plus events on selected themes from the IYPE science program, particularly on Megacities, Hazards, Resources and Biodiversity. Mexico City metropolitan area, with > 22 million inhabitants presents special challenges, being at high altitude within an active tectonic and volcanic area requiring major efforts in water supply, water control, rains and waste disposal and management. Involvement in international activities includes OneGeology, translation into Spanish of IYPE thematic leaflets and participation in meetings and outreach activities. A major long-lasting legacy of IYPE is the formation of links/partnerships within Latin America and in the international context. Consolidating and expanding cooperation/partnership in research, education and outreach will then be our major challenges. In addition to future plans in different countries and regions, we consider that IYPE should develop long-term initiatives for enhancing international cooperation and ensuring increased effective use by society of the Earth and space sciences.

Identifying Criegee Intermediates As Potential Oxidants In The Troposphere

NASA Astrophysics Data System (ADS)

Novelli, A.; Hens, K.; Tatum Ernest, C.; Martinez, M.; Nölscher, A. C.; Sinha, V.; Paasonen, P.; Petäjä, T.; Sipilä, M.; Elste, T.; Plass-Duelmer, C.; Kubistin, D.; Phillips, G. J.; Williams, J.; Vereecken, L.; Lelieveld, J.; Harder, H.

2015-12-01

Criegee intermediates (CI) are formed during the ozonolysis of unsaturated compounds and have been intensively studied in the last few years due to their possible role as oxidants in the troposphere. Stabilised CI (SCI) are now known to react very rapidly, k(298 K) = 10-12 to 10-10 cm3 molecule-1 s-1, with a large number of trace gases (SO2, NO2, organic acids, water dimers). An assessment of their effective oxidative capacity remain challenging as, CI chemistry is complex, it spans a large range of rate coefficients for different SCI conformers reacting with water dimers and trace gases, and in addition, no reliable measurement technique able to detect ambient SCI concentrations is currently available. In this study, we examine the extensive dataset from the HUMPPA-COPEC 2010 and the HOPE 2012 field campaigns, aided by literature data, to estimate the abundance of SCI in the lower troposphere. The budget of SCI is analyzed using four different approaches: 1) based on an observed yet unexplained H2SO4 production; 2) from the measured concentrations of unsaturated volatile organic compounds (VOC); 3) from OH reactivity measurements; 4) from the unexplained production rate of OH. A SCI concentration range between 5 x 103 and 2 x 106 molecule cm-3 is calculated for the two environments. The weighted mean estimate of the SCI concentration over the boreal forest of ~ 5 x 104 molecules cm-3 implies a significant impact on the conversion of SO2 into H2SO4. In addition, we present measurements obtained using our inlet pre-injector laser-induced fluorescence assay by gas expansion technique (IPI-LIF-FAGE) for the above-mentioned campaigns. A recent laboratory study performed with the same instrumental setup showed that the IPI-LIF-FAGE system is sensitive to the detection of the OH formed from unimolecular decomposition of SCI. In order to investigate the applicability of the laboratory findings to the ambient data, measurement of the background OH (OHbg), the signal detected by the IPI-LIF-FAGE after the removal of ambient OH, measured during the two field campaigns are represented in comparison with many other trace gases to assess if the observations in controlled conditions are transferable to ambient conditions.

A new prognostic score for elderly patients with diffuse large B-cell lymphoma treated with R-CHOP: the prognostic role of blood monocyte and lymphocyte counts is absent.

PubMed

Procházka, Vít; Pytlík, Robert; Janíková, Andrea; Belada, David; Sálek, David; Papajík, Tomáš; Campr, Vít; Fürst, Tomáš; Furstova, Jana; Trněný, Marek

2014-01-01

Absolute lymphocyte count (ALC) and absolute monocyte count (AMC) have been documented as independent predictors of survival in patients with newly diagnosed Diffuse Large B-cell Lymphoma (DLBCL). Analysis of the prognostic impact of ALC and AMC in the context of International Prognostic Index (IPI) and other significant variables in elderly population treated in the R-CHOP regime has not been carried out yet. In this retrospective study, a cohort of 443 newly diagnosed DLBCL patients with age ≥ 60 was analyzed. All patients were treated with the R-CHOP therapy. An extensive statistical analysis was performed to identify risk factors of 3-year overall survival (OS). In multivariate analysis, only three predictors proved significant: Eastern Cooperative Oncology Group performance status (ECOG), age and bulky disease presence. These predictors were dichotomized (ECOG ≥ 1, age ≥ 70, bulk ≥ 7.5) to create a novel four-level score. This score predicted 3-year OS of 94.0%, 77.4%, 62.7% and 35.4% in the low-, low-intermediate, high-intermediate and high-risk groups, respectively (P<0.001). Further, a three-level score was tested which stratifies the population better (3-year OS: 91.9%, 67.2%, 36.2% in the low, intermediate and high-risk groups, respectively) but is more difficult to interpret. Both the 3- and 4-level scores were compared to standard scoring systems and, in our population, were shown to be superior in terms of patients risk stratification with respect to 3-year OS prediction. The results were successfully validated on an independent cohort of 162 patients of similar group characteristics. The prognostic role of baseline ALC, AMC or their ratio (LMR) was not confirmed in the multivariate context in elderly population with DLBCL treated with R-CHOP. The newly proposed age-specific index stratifies the elderly population into risk groups more precisely than the conventional IPI and its existing variants.

Effect of the bacillus of Calmette-Guérin, Propionibacter acnes and avridine as immunomodulators in antirabies vaccination of mice using the Fuenzalida-Palacios mouse brain vaccine.

PubMed

Megid, J; Peraçolli, M T; Curi, P R; Zanetti, C R; Cabrera, W H; Vassao, R; Ito, F H

1999-05-14

Using the laboratory mice, Fuenzalida-Palacios mouse brain human rabies vaccine was administered in groups of animals previously inoculated with rabies virus and then submitted to treatments with the immunomodulators onco-BCG, avridine and Propionibacterium acnes. Humoral and cellular immune responses were evaluated through the macrophage inhibition factor (MIF), intra-pad inoculation (IPI) and serum neutralization (SN) tests and by the detection of gamma-interferon (IFN-gamma). The IPI test was not effective in detecting the response of delayed-type hypersensitivity, contrary to MIF, which showed the immune cellular response. Higher levels of IFN-gamma were observed in the groups of mice vaccinated and treated with avridine and P. acnes. Although immunomodulating activities have been detected, the use of adjuvants with the Fuenzalida-Palacios type vaccine in mice did not reveal any encouraging results.

Environmental Studies in the Boreal Forest Zone: Summer IPY Institute at Central Boreal Forest Reserve, Fedorovskoe, Tver area, Russia (14-28 August, 2007)

NASA Astrophysics Data System (ADS)

Sparrow, E. B.; Kurbatova, Y.; Groisman, P.; Alexeev, V.

2007-12-01

The Summer Institute was organized by the International Arctic Research Center (IARC) at the University of Alaska Fairbanks, in collaboration with the A.N. Severtsov Institute for Ecology and Evolution of the Russian Academy of Sciences in Moscow, Russia, and the Central Forest State Nature Biosphere Reserve in Fedorovskoe, Russia. The Institute was arranged as a part of the education/outreach activities of the International Polar Year (IPY) at the University of Alaska and the Northern Eurasia Earth Science Partnership Initiative (NEESPI) and was held in Russia. The Institute provided a unique opportunity for participants to learn about the climate and environment of Northern Eurasia from leading scientists and educators, in a wide spectrum of polar and Earth system science disciplines from meteorology, biology, chemistry, and earth system modeling. Additionally, the Institute attendees observed and participated in the biospheric research activities under the guidance of experienced scientists. During a two-week-interval, the School attendees heard 40 lectures, attended several field trips and participated in three brainstorming Round Table Workshop Sessions devoted to perspectives of the boreal forest zone research and major unresolved problems that it faces. Thirty professors and experts in different areas of climate and biosphere research from Russia, the United States, Germany, Finland, and Japan, shared their expertise in lectures and in round table discussions with the Institute participants. Among the Institute participants there were 31 graduate students/early career scientists from six countries (China, Russia, Estonia, Finland, UK, and the United States) and eight K-12 teachers from Russia. The two groups joined together for several workshop sessions and for the field work components of the Institute. The field work was focused on land-atmosphere interactions and wetland studies in the boreal forest zone. Several field trips in and outside the Forest Reserve were arranged to highlight various aspects of wetland studies and management in the European taiga environment. As part of the GLOBE (Global Learning and Observations to Benefit the Environment) IPY "Seasons and Biomes" project led by Dr. Elena Sparrow, the K-12 teachers were instructed in and practiced existing GLOBE protocols as well as new protocols created specifically for the Seasons and Biomes project to study interannual variability of seasons in their own biomes. These teachers will in turn engage their students in Earth System scientific research as a way of teaching and learning science as well as involving them in the IPY. Support for the Summer Institute was provided by many institutions and organizations from the United States (IARC, NASA, NSF, University of Maryland, GLOBE USA, and Hydrology Science and Services Corporation), Russia (Central Biosphere Forest Reserve, A.N. Severtsov Institute for Ecology and Evolution of the Russian Academy of Sciences, Southern Federal University, Russian Foundation for Basic Research, GLOBE Russia, and non-profit organization "Transparent World"), Japan (National Institute for Environmental Studies), China (Beijing Normal University), Germany (Friedrich-Schiller-University) and the Circumpolar North (University of the Arctic).

Residing in economically distressed rural Appalachia is independently associated with excess body weight in college students.

PubMed

Abshire, Demetrius A; Lennie, Terry A; Mudd-Martin, Gia T; Moser, Debra K

2017-01-01

The prevalence of obesity is greater among adults living in rural compared to urban areas of the USA. Greater obesity risk among rural adults persists after adjusting for obesity-related behaviors and sociodemographic factors. With the rural-urban obesity disparity greatest among younger adults, it is important to examine the complexity of factors that may increase the risk for excess body weight in this population so that effective preventive interventions can be implemented. College students residing in economically deprived rural areas such as rural Appalachia may be particularly at risk for excess body weight from exposure to both rural and college obesogenic environments. The purpose of this study was to determine if living in economically distressed rural Appalachia is independently associated with excess body weight among college students. College students aged 18-25 years who were lifetime residents of either rural Eastern Appalachian Kentucky (n=55) or urban Central Kentucky (n=54) participated in this cross-sectional study. Students completed questionnaires on sociodemographics, depressive symptoms, and health behaviors including smoking, fruit and vegetable intake, and physical activity. Height and weight were obtained during a brief health examination to calculate body-mass index (BMI). Excess body weight was defined as being overweight or obese with a BMI of 25 kg/m2 or greater. Binary logistic regression was used to determine if living in economically distressed rural Appalachia was independently associated with excess body weight. The prevalence of excess body weight was higher in the rural Appalachian group than the urban group (50% vs 24%, p0.001). Depressive symptom scores and smoking prevalence were also greater in the rural Appalachian group. There were no differences in fruit and vegetable intake and vigorous physical activity between the groups. Residing in economically distressed rural Appalachia was associated with more than a six-fold increased risk of overweight or obesity, controlling for sociodemographics, depressive symptoms, and health behaviors (odds ratio=6.36, 95%CI=1.97-20.48, p=0.002). Living in economically distressed rural Appalachia was associated with excess body weight in college students independent of sociodemographic factors, depressive symptoms, and obesity-related behaviors. Further research is needed to determine other characteristics of this region that are associated with excess body weight so that effective programs to reduce obesity risk can be implemented.

The expression and clinical relevance of PD-1, PD-L1, and TP63 in patients with diffuse large B-cell lymphoma

PubMed Central

Fang, Xia; Xiu, Bing; Yang, Zhizhang; Qiu, Weizhe; Zhang, Long; Zhang, Suxia; Wu, Yunjin; Zhu, Xuyou; Chen, Xue; Xie, Suhong; Yi, Xianghua; Liang, Aibin; Zeng, Yu

2017-01-01

Abstract Latest study showed that a novel translocation between programmed cell death ligand 1 (PD-L1) (cluster of differentiation 274) and TP63 (tumor protein 63) can be found in diffuse large B-cell lymphoma (DLBCL), resulting in their conjunct overexpression in tumor cells at RNA level. However, the expressed pattern of these 2 genes at protein level in DLBCL remains largely unknown, and the clinical relevance of PD-L1 and TP63 expression in DLBCL are also unclear. Tumor tissues from 76 Chinese DLBCL patients were immunostained for programmed cell death 1 (PD-1), PD-L1, and TP63 using the EnVision system. Clinical relevance of PD-1, PD-L1, and TP63 in 74 DLBCL were analyzed by chi-square test, the Kaplan–Meier curves with log rank test, and Cox's proportional hazards regression model. PD-1 was mainly expressed in tumor-infiltrating lymphocytes (TILs) of 39.5% patients. PD-L1 was expressed in tumor cells of 26.3% patients, and TP63 was immunostained in nucleoli of tumor cells of 31.6% cases. PD-1 expression was significantly associated with the patients’ gender and B symptoms (P = 0.032, P = 0.026). DLBCL with PD-L1 or TP63 expression in tumor cells showed low International Prognostic Index (IPI) score (P = 0.007, P = 0.009). PD-1+ TILs was related to prolonged overall survival rate (OS) of DLBCL patients (P = 0.02), whereas PD-L1 expression was associated with worse clinical outcome of patients (P = 0.049). Immunoreactivity of TP63 was not correlated with patients’ survival time. Besides, PD-1 expression, patients’ age, Ann Arbor stage, and IPI score were significant prognostic markers for OS, but PD-L1 and TP63 had no prognostic significance. PD-1, PD-L1, and TP63 are frequently expressed in DLBCL. PD-1/PD-L1/TP63 blockade may be a potential therapeutic strategy for some patients. PMID:28403071

The expression and clinical relevance of PD-1, PD-L1, and TP63 in patients with diffuse large B-cell lymphoma.

PubMed

Fang, Xia; Xiu, Bing; Yang, Zhizhang; Qiu, Weizhe; Zhang, Long; Zhang, Suxia; Wu, Yunjin; Zhu, Xuyou; Chen, Xue; Xie, Suhong; Yi, Xianghua; Liang, Aibin; Zeng, Yu

2017-04-01

Latest study showed that a novel translocation between programmed cell death ligand 1 (PD-L1) (cluster of differentiation 274) and TP63 (tumor protein 63) can be found in diffuse large B-cell lymphoma (DLBCL), resulting in their conjunct overexpression in tumor cells at RNA level. However, the expressed pattern of these 2 genes at protein level in DLBCL remains largely unknown, and the clinical relevance of PD-L1 and TP63 expression in DLBCL are also unclear.Tumor tissues from 76 Chinese DLBCL patients were immunostained for programmed cell death 1 (PD-1), PD-L1, and TP63 using the EnVision system. Clinical relevance of PD-1, PD-L1, and TP63 in 74 DLBCL were analyzed by chi-square test, the Kaplan-Meier curves with log rank test, and Cox's proportional hazards regression model.PD-1 was mainly expressed in tumor-infiltrating lymphocytes (TILs) of 39.5% patients. PD-L1 was expressed in tumor cells of 26.3% patients, and TP63 was immunostained in nucleoli of tumor cells of 31.6% cases. PD-1 expression was significantly associated with the patients' gender and B symptoms (P = 0.032, P = 0.026). DLBCL with PD-L1 or TP63 expression in tumor cells showed low International Prognostic Index (IPI) score (P = 0.007, P = 0.009). PD-1 TILs was related to prolonged overall survival rate (OS) of DLBCL patients (P = 0.02), whereas PD-L1 expression was associated with worse clinical outcome of patients (P = 0.049). Immunoreactivity of TP63 was not correlated with patients' survival time. Besides, PD-1 expression, patients' age, Ann Arbor stage, and IPI score were significant prognostic markers for OS, but PD-L1 and TP63 had no prognostic significance.PD-1, PD-L1, and TP63 are frequently expressed in DLBCL. PD-1/PD-L1/TP63 blockade may be a potential therapeutic strategy for some patients.

SETI-Italia 2003 status report and first results of a KL transform algorithm for ETI signal detection

NASA Astrophysics Data System (ADS)

Montebugnoli, S.; Bortolotti, C.; Cattani, A.; Maccaferri, A.; Orlati, A.; Poloni, M.; Poppi, S.; Monari, J.; Roma, M.; Pari, P. P.; Teodorani, M.; Righini, S.; Maccone, C.; Caliendo, D.; Cosmovici, C. B.; D'Amico, N.

2006-02-01

SETI-Italia is the Italian national SETI Program. It is run as a part of the Italian Bioastronomy Project, by IRA (Istituto di Radioastronomia) a subsidiary of the Istituto Nazionale di Astrofisica. At the moment, Italy is the only European country conducting a continuous SETI “listening” program, while occasional SETI searches may be conducted in France and the Ukraine. Outside Europe, continuous SETI programs are conducted in the USA, Australia and Argentina. The SETI-Italia activities started early in 1998 with a Serendip IV system connected in piggy-back mode to the Medicina VLBI 32-m antenna dish. In the years 2002/2003, considerable efforts were devoted to set up a fast computational system capable of computing the KLT (Karhunen Loève transform). This is a virtually new mathematical procedure in SETI, and is much more general than the FFT. It can search for the presence of signals both narrow-band and wide-band embedded in noise both coloured and white. The mathematical features the KLT have already been described in this Conference by Claudio Maccone [Innovative SETI by the KLT, Pešek Lecture 2003, paper # IAA.9.1.01 presented in Bremen, in this 2003 International Astronautical Congress [1]; Telecommunications, KLT and Relativity, vol. 1, IPI Press, Colorado Springs, CO, 1994, ISBN #1-880930-04-8 [2].]. Our software implementation of the KLT follows these lines and also is indebted to some basic ideas put forward by Robert S. Dixon [On the detection of unknown signals, in: G. Seth Shostak (Ed.), Third Decennial US USSR Conference on SETI, Astronomical Society of the Pacific Conference Series, vol. 47, 1993, pp. 128 140] of the Ohio State Radio Observatory as early as 1993.

Poverty assessment using DMSP/OLS night-time light satellite imagery at a provincial scale in China

NASA Astrophysics Data System (ADS)

Wang, Wen; Cheng, Hui; Zhang, Li

2012-04-01

All countries around the world and many international bodies, including the United Nations Development Program (UNDP), United Nations Food and Agricultural Organization (FAO), the International Fund for Agricultural Development (IFAD) and the International Labor Organization (ILO), have to eliminate rural poverty. Estimation of regional poverty level is a key issue for making strategies to eradicate poverty. Most of previous studies on regional poverty evaluations are based on statistics collected typically in administrative units. This paper has discussed the deficiencies of traditional studies, and attempted to research regional poverty evaluation issues using 3-year DMSP/OLS night-time light satellite imagery. In this study, we adopted 17 socio-economic indexes to establish an integrated poverty index (IPI) using principal component analysis (PCA), which was proven to provide a good descriptor of poverty levels in 31 regions at a provincial scale in China. We also explored the relationship between DMSP/OLS night-time average light index and the poverty index using regression analysis in SPSS and a good positive linear correlation was modelled, with R2 equal to 0.854. We then looked at provincial poverty problems in China based on this correlation. The research results indicated that the DMSP/OLS night-time light data can assist analysing provincial poverty evaluation issues.

Calibrating the Iowa pore index with mercury intrusion porosimetry and petrography.

DOT National Transportation Integrated Search

2017-10-31

The Iowa Pore Index (IPI) test is a fast, non-destructive, inexpensive, and environmentally friendly test used by several Midwestern state departments of transportation to determine the volume ratio of macropores to micropores in a coarse rock aggreg...

Time to treatment is an independent prognostic factor in aggressive non-Hodgkin lymphomas.

PubMed

Olszewski, Adam J; Ollila, Thomas; Reagan, John L

2018-04-24

In aggressive lymphomas, discrepancies in survival reported from experimental and observational studies may reflect selective non-enrolment of high-risk patients in trials. We examined the association between time from diagnosis to chemotherapy and overall survival in diffuse large B-cell (DLBCL), Burkitt (BL), mantle cell (MCL) and peripheral T-cell lymphoma (PTCL), using National Cancer Data Base records of 130 549 patients treated in 2004-2014. Across the histologies, patients who started chemotherapy within 7 days of diagnosis had more often high International Prognostic Index (IPI) or advanced-stage disease. The discrepancy in 3-year survival between groups treated within 7 or >30 days from diagnosis ranged from 14% in BL to 30% in MCL. After adjusting for the IPI, time to treatment was significantly associated with shorter overall survival. Using the group treated >30 days from diagnosis as reference, patients treated within 7 days had a hazard ratio of 1·38 [95% confidence interval (CI), 1·28-1·48] in DLBCL, 1·42 (95% CI, 1·22-1·66) in BL, 2·23 (95% CI, 1·79-2·78) in MCL and 1·46 (95% CI, 1·18-1·81) in PTCL. Time from diagnosis to treatment may reflect high-risk features uncaptured by standard prognostic assessments. Clinical trials should accommodate patients who need urgent therapy to improve external validity and detect treatment effects in high-risk groups. © 2018 John Wiley & Sons Ltd.

Dynamics relationship between stock prices and economic variables in Malaysia

NASA Astrophysics Data System (ADS)

Chun, Ooi Po; Arsad, Zainudin; Huen, Tan Bee

2014-07-01

Knowledge on linkages between stock prices and macroeconomic variables are essential in the formulation of effective monetary policy. This study investigates the relationship between stock prices in Malaysia (KLCI) with four selected macroeconomic variables, namely industrial production index (IPI), quasi money supply (MS2), real exchange rate (REXR) and 3-month Treasury bill (TRB). The variables used in this study are monthly data from 1996 to 2012. Vector error correction (VEC) model and Kalman filter (KF) technique are utilized to assess the impact of macroeconomic variables on the stock prices. The results from the cointegration test revealed that the stock prices and macroeconomic variables are cointegrated. Different from the constant estimate from the static VEC model, the KF estimates noticeably exhibit time-varying attributes over the entire sample period. The varying estimates of the impact coefficients should be better reflect the changing economic environment. Surprisingly, IPI is negatively related to the KLCI with the estimates of the impact slowly increase and become positive in recent years. TRB is found to be generally negatively related to the KLCI with the impact fluctuating along the constant estimate of the VEC model. The KF estimates for REXR and MS2 show a mixture of positive and negative impact on the KLCI. The coefficients of error correction term (ECT) are negative in majority of the sample period, signifying the stock prices responded to stabilize any short term deviation in the economic system. The findings from the KF model indicate that any implication that is based on the usual static model may lead to authorities implementing less appropriate policies.

Association between anaemia, iron deficiency anaemia, neglected parasitic infections and socioeconomic factors in rural children of West Malaysia.

PubMed

Ngui, Romano; Lim, Yvonne Ai Lian; Chong Kin, Liam; Sek Chuen, Chow; Jaffar, Shukri

2012-01-01

Given that micronutrient deficiency, neglected intestinal parasitic infections (IPIs) and poor socioeconomic status are closely linked, we conducted a cross-sectional study to assess the relationship between IPIs and nutritional status of children living in remote and rural areas in West Malaysia. A total of 550 children participated, comprising 520 (94.5%) school children aged 7 to 12 years old, 30 (5.5%) young children aged 1 to 6 years old, 254 (46.2%) boys and 296 (53.8%) girls. Of the 550 children, 26.2% were anaemic, 54.9% iron deficient and 16.9% had iron deficiency anaemia (IDA). The overall prevalence of helminths was 76.5% comprising Trichuris trichiura (71.5%), Ascaris lumbricoides (41.6%) and hookworm infection (13.5%). It was observed that iron deficiency was significantly higher in girls (p = 0.032) compared to boys. Univariate analysis demonstrated that low level of mother's education (OR = 2.52; 95% CI = 1.38-4.60; p = 0.002), non working parents (OR = 2.18; 95% CI = 2.06-2.31; p = 0.013), low household income (OR = 2.02; 95% CI = 1.14-3.59; p = 0.015), T. trichiura (OR = 2.15; 95% CI = 1.21-3.81; p = 0.008) and A. lumbricoides infections (OR = 1.63; 95% CI = 1.04-2.55; p = 0.032) were significantly associated with the high prevalence of IDA. Multivariate analysis confirmed that low level of mother's education (OR = 1.48; 95 CI% = 1.33-2.58; p<0.001) was a significant predictor for IDA in these children. It is crucial that a comprehensive primary health care programme for these communities that includes periodic de-worming, nutrition supplement, improved household economy, education, sanitation status and personal hygiene are taken into consideration to improve the nutritional status of these children.

TP53 mutation and survival in aggressive B cell lymphoma.

PubMed

Zenz, Thorsten; Kreuz, Markus; Fuge, Maxi; Klapper, Wolfram; Horn, Heike; Staiger, Annette M; Winter, Doris; Helfrich, Hanne; Huellein, Jennifer; Hansmann, Martin-Leo; Stein, Harald; Feller, Alfred; Möller, Peter; Schmitz, Norbert; Trümper, Lorenz; Loeffler, Markus; Siebert, Reiner; Rosenwald, Andreas; Ott, German; Pfreundschuh, Michael; Stilgenbauer, Stephan

2017-10-01

TP53 is mutated in 20-25% of aggressive B-cell lymphoma (B-NHL). To date, no studies have addressed the impact of TP53 mutations in prospective clinical trial cohorts. To evaluate the impact of TP53 mutation to current risk models in aggressive B-NHL, we investigated TP53 gene mutations within the RICOVER-60 trial. Of 1,222 elderly patients (aged 61-80 years) enrolled in the study and randomized to six or eight cycles of CHOP-14 with or without Rituximab (NCT00052936), 265 patients were analyzed for TP53 mutations. TP53 mutations were demonstrated in 63 of 265 patients (23.8%). TP53 mutation was associated with higher LDH (65% vs. 37%; p < 0.001), higher international prognostic index-Scores (IPI 4/5 27% vs. 12%; p = 0.025) and B-symptoms (41% vs. 24%; p = 0.011). Patients with TP53 mutation were less likely to obtain a complete remission CR/CRu (CR unconfirmed) 61.9% (mut) vs. 79.7% (wt) (p = 0.007). TP53 mutations were associated with decreased event-free (EFS), progression-free (PFS) and overall survival (OS) (median observation time of 40.2 months): the 3 year EFS, PFS and OS were 42% (vs. 60%; p = 0.012), 42% (vs. 67.5%; p < 0.001) and 50% (vs. 76%; p < 0.001) for the TP53 mutation group. In a Cox proportional hazard analysis adjusting for IPI-factors and treatment arms, TP53 mutation was shown to be an independent predictor of EFS (HR 1.5), PFS (HR 2.0) and OS (HR 2.3; p < 0.001). TP53 mutations are independent predictors of survival in untreated patients with aggressive CD20+ lymphoma. TP53 mutations should be considered for risk models in DLBCL and strategies to improve outcome for patients with mutant TP53 must be developed. © 2017 UICC.

Development and preliminary evaluation of an integrated treatment targeting parenting and depressive symptoms in mothers of children with attention-deficit/hyperactivity disorder.

PubMed

Chronis-Tuscano, Andrea; Clarke, Tana L; O'Brien, Kelly A; Raggi, Veronica L; Diaz, Yamalis; Mintz, Abigail D; Rooney, Mary E; Knight, Laura A; Seymour, Karen E; Thomas, Sharon R; Seeley, John; Kosty, Derek; Lewinsohn, Peter

2013-10-01

More than 50% of mothers of children with attention-deficit/hyperactivity disorder (ADHD) have a lifetime history of major depressive disorder (MDD). Maternal depressive symptoms are associated with impaired parenting and predict adverse developmental and treatment outcomes for children with ADHD. For these reasons, we developed and examined the preliminary efficacy of an integrated treatment targeting parenting and depressive symptoms for mothers of children with ADHD. This integrated intervention incorporated elements of 2 evidence-based treatments: behavioral parent training (BPT) and cognitive behavioral depression treatment. Ninety-eight mothers with at least mild depressive symptoms were randomized to receive either standard BPT (n = 51) or the integrated parenting intervention for ADHD (IPI-A; n = 47). Participants were assessed at baseline, posttreatment, and 3- to 6-month follow-up on measures of (a) self-reported maternal depressive symptoms, (b) observed positive and negative parenting, and (c) observed and mother-reported child disruptive behavior and mother-reported child and family impairment. The IPI-A produced effects of small to moderate magnitude relative to BPT on maternal depressive symptoms, observed negative parenting, observed child deviance, and child impairment at posttreatment and on maternal depressive symptoms, child disruptive behavior, child impairment and family functioning at follow-up. Contrary to expectations, the BPT group demonstrated moderate to large effects relative to IPI-A on observed positive parenting at follow-up. This treatment development study provides encouraging preliminary support for the integrated intervention targeting parenting and depressive symptoms in mothers of children with ADHD. Future studies should examine whether this integrated intervention improves long-term developmental outcomes for children with ADHD. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

Electron Microscopic Evaluation and Fission Product Identification of Irradiated TRISO Coated Particles from the AGR-1 Experiment: A Preliminary Review

DOE Office of Scientific and Technical Information (OSTI.GOV)

IJ van Rooyen; DE Janney; BD Miller

2014-05-01

Post-irradiation examination of coated particle fuel from the AGR-1 experiment is in progress at Idaho National Laboratory and Oak Ridge National Laboratory. In this paper a brief summary of results from characterization of microstructures in the coating layers of selected irradiated fuel particles with burnup of 11.3% and 19.3% FIMA will be given. The main objectives of the characterization were to study irradiation effects, fuel kernel porosity, layer debonding, layer degradation or corrosion, fission-product precipitation, grain sizes, and transport of fission products from the kernels across the TRISO layers. Characterization techniques such as scanning electron microscopy, transmission electron microscopy, energymore » dispersive spectroscopy, and wavelength dispersive spectroscopy were used. A new approach to microscopic quantification of fission-product precipitates is also briefly demonstrated. Microstructural characterization focused on fission-product precipitates in the SiC-IPyC interface, the SiC layer and the fuel-buffer interlayer. The results provide significant new insights into mechanisms of fission-product transport. Although Pd-rich precipitates were identified at the SiC-IPyC interlayer, no significant SiC-layer thinning was observed for the particles investigated. Characterization of these precipitates highlighted the difficulty of measuring low concentrations of Ag in precipitates with significantly higher concentrations of Pd and U. Different approaches to resolving this problem are discussed. An initial hypothesis is provided to explain fission-product precipitate compositions and locations. No SiC phase transformations were observed and no debonding of the SiC-IPyC interlayer as a result of irradiation was observed for the samples investigated. Lessons learned from the post-irradiation examination are described and future actions are recommended.« less

Mathematical modeling and spectrum analysis of the physiological patello-femoral pulse train produced by slow knee movement.

PubMed

Zhang, Y T; Frank, C B; Rangayyan, R M; Bell, G D

1992-09-01

Analysis of vibration signals emitted by the knee joint has the potential for the development of a noninvasive procedure for the diagnosis and monitoring of knee pathology. In order to obtain as much information as possible from the power density spectrum of the knee vibration signal, it is necessary to identify the physiological factors (or physiologically relevant parameters) that shape the spectrum. This paper presents a mathematical model for knee vibration signals, in particular the physiological patello-femoral pulse (PFP) train produced by slow knee movement. It demonstrates through the mathematical model that the repetition rate of the physiological PFP train introduces repeated peaks in the power spectrum, and that it affects the spectrum mainly at low frequencies. The theoretical results also show that the spectral peaks at multiples of the PFP repetition rate become more evident when the variance of the interpulse interval (IPI) is small, and that these spectral peaks shift toward higher frequencies with increasing PFP repetition rates. To evaluate the mathematical model, a simulation algorithm was developed, which generates PFP signals with adjustable repetition rate and IPI variance. Signals generated by simulation were seen to possess representative spectral characteristics typically observed in physiological PFP signals. This simulation procedure allows an interactive examination of several factors which affect the PFP train spectrum. Finally, in vivo measurements of physiological PFP signals of normal volunteers are presented. Results of simulations and analysis of signals recorded from human subjects support the mathematical model's prediction that the IPI statistics play a very significant role in determining the low-end power spectrum of the physiological PFP signal.(ABSTRACT TRUNCATED AT 250 WORDS)

Low T3 syndrome as a predictor of poor prognosis in chronic lymphocytic leukemia.

PubMed

Gao, Rui; Chen, Rui-Ze; Xia, Yi; Liang, Jin-Hua; Wang, Li; Zhu, Hua-Yuan; Zhu Wu, Jia-; Fan, Lei; Li, Jian-Yong; Yang, Tao; Xu, Wei

2018-02-19

Low triiodothyronine (T3) state is associated with poor prognosis in critical acute and prolonged illness. However, the information on thyroid dysfunction and cancer is limited. The aim of our study was to evaluate the prognostic value of low T3 syndrome in chronic lymphocytic leukemia (CLL). Two hundred and fifty-eight patients with detailed thyroid hormone profile at CLL diagnosis were enrolled. Low T3 syndrome was defined by low free T3 (FT3) level accompanied by normal-to-low free tetraiodothyronine (FT4) and thyroid-stimulating hormone (TSH) levels. A propensity score-matched method was performed to balance the baseline characteristics. Multivariate Cox regression analyses screened the independent prognostic factors related to time-to-first-treatment (TTFT) and cancer-specific survival (CSS). Area under the curve (AUC) assessed the predictive accuracy of CLL-International Prognostic Index (IPI) together with low T3 syndrome. The results showed that 37 (14.34%) patients had low T3 syndrome, which was significantly associated with unfavorable TTFT and CSS in the propensity-matched cohort, and it was an independent prognostic indicator for both TTFT and CSS. Serum FT3 level was positively related to protein metabolism and anemia, and inversely related to inflammatory state. Patients with only low FT3 demonstrated better survival than those with synchronously low FT3 and FT4, while those with synchronously low FT3, FT4 and TSH had the worst clinical outcome. Low T3 syndrome together with CLL-IPI had larger AUCs compared with CLL-IPI alone in TTFT and CSS prediction. In conclusion, low T3 syndrome may be a good candidate for predicting prognosis in future clinical practice of CLL. © 2018 UICC.

Leaving School — learning at SEA: Regular high school education alongside polar research, not only during IPY

NASA Astrophysics Data System (ADS)

Gatti, S.

2006-12-01

Against the background of unsatisfactory results from the international OECD study PISA (Program for International Student Assessment), Germany is facing a period of intense school reforms. Looking back at a tradition of school culture with too few changes during the last century, quick and radical renewal of the school system is rather unlikely. Furthermore students are increasingly turning away from natural sciences. The AWI aims at providing impulses for major changes in the schooling system and is offering solid science education not only for university students but also for a much younger audience. All efforts towards this goal are interconnected within the project SEA (Science & Education @ the AWI). Fife years ago the AWI started HIGHSEA (High school of SEA). Each year 22 high school students (grade 11) are admitted to HIGHSEA spending their last three years of school not at school but at the institute. Four subjects (biology as a major, chemistry, math and English as accessory subjects) are combined and taught fully integrated. Students leave their schools for two days each week to study, work and explore all necessary topics at the AWI. All of the curricular necessities of the four subjects are being met. After rearrangement of the temporal sequencing conceptual formulation of four major questions around AWI-topics was possible. Students are taught by teachers of the cooperating schools as well as by scientists of the AWI. Close links and intense cooperation between all three groups are the basis of fundamental changes in teaching and learning climate. For each group of students we organize a short research expedition: in August 2005 we worked in the high Arctic, in January and February 2006 we performed measurements at two eastern Atlantic seamounts. Even if the amount of data coming from these expeditions is comparatively small they still contribute to ongoing research projects of the oceanographic department. The first two groups of students finished their final exams — with outstanding results. External evaluation of HIGHSEA performed by the University Duisburg-Essen presents spectacular results of HIGHSEA students when compared with a control group. By exploring and establishing new ways of teaching and learning we are contributing to the ongoing discussion about the renewal of the German school system. Drawing on our rich experience in cooperation with local schools we are offering an international role-play game focusing around the sustainable use of Polar regions in times of global climate change. After regional, national and international runs of the game the activities will culminate during an international "World Youth Polar Conference" (WYPC) late in 2007. We offer the unique opportunity for researchers in the field of polar research to actively contribute to a major outreach activity during IPY and participate in our role-play as national ambassadors.

Teaching the Teachers: Physical Science for the Non-Scientific

NASA Astrophysics Data System (ADS)

Michels, D. J.; Pickert, S. M.; Montrose, C. J.; Thompson, J. L.

2004-12-01

The Catholic University of America, in collaboration with the Solar Physics Branch of the Naval Research Laboratory and the Goddard Space Flight Center, has begun development of an experimental, inquiry-driven and standards-referenced physical science course for undergraduate, pre-service K-8 teachers. The course is team-taught by faculty from the University's Departments of Education and Physics and NRL solar physics research personnel. Basic physical science concepts are taught in the context of the Sun and Sun-Earth Connections, through direct observation, web-based solar data, and images and movies from ongoing space missions. The Sun can illuminate, in ways that cannot be duplicated with comparable clarity in the laboratory, the basics of magnetic and gravitational force fields, Newton's Laws, and light and optics. The immediacy of the connection to ongoing space research and live mission data serves as well to inspire student interest and curiosity. Teaching objectives include pedagogical methods, especially hands-on and observational experiences appropriate to the physics content and the K-8 classroom. The CUA Program, called TOPS! (Top Teachers of Physical Science!) has completed its first year of classroom experience; the first few batches of Program graduates should be in K-8 classrooms in time to capitalize on the motivational opportunities offered by the 2007-2008 IHY and IPY. We present data on the attitudinal and scientific progress of fifteen pre-service Early Childhood and Elementary Education majors as they experienced, many for the first time, the marvels of attractive and repulsive forces, live observations of solar system dynamics, access to real-time satellite data and NASA educational resources.

Using prognostic models in CLL to personalize approach to clinical care: Are we there yet?

PubMed

Mina, Alain; Sandoval Sus, Jose; Sleiman, Elsa; Pinilla-Ibarz, Javier; Awan, Farrukh T; Kharfan-Dabaja, Mohamed A

2018-03-01

Four decades ago, two staging systems were developed to help stratify CLL into different prognostic categories. These systems, the Rai and the Binet staging, depended entirely on abnormal exam findings and evidence of anemia and thrombocytopenia. Better understanding of biologic, genetic, and molecular characteristics of CLL have contributed to better appreciating its clinical heterogeneity. New prognostic models, the GCLLSG prognostic index and the CLL-IPI, emerged. They incorporate biologic and genetic information related to CLL and are capable of predicting survival outcomes and cases anticipated to need therapy earlier in the disease course. Accordingly, these newer models are helping develop better informed surveillance strategies and ultimately tailor treatment intensity according to presence (or lack thereof) of certain prognostic markers. This represents a step towards personalizing care of CLL patients. We anticipate that as more prognostic factors continue to be identified, the GCLLSG prognostic index and CLL-IPI models will undergo further revisions. Copyright © 2017 Elsevier Ltd. All rights reserved.

Assessing Adolescents’ Attachment Hierarchies: Differences Across Developmental Periods and Associations With Individual Adaptation

PubMed Central

Rosenthal, Natalie L.; Kobak, Roger

2012-01-01

Adolescents’ attachment hierarchies were assessed in a sample of 212 high school and 198 college students. The Important People Interview (IPI) differentiated attachment bonds from other supportive or affiliative relationships and indicated that adolescents show a hierarchical ordering of preferences for multiple attachment figures. Differences in the composition and structure of adolescents’ attachment hierarchies were found between the early high school (9th and 10th grades), later high school (11th and 12th grades), and college samples. In the college sample, romantic partners were placed in higher positions in adolescents’ hierarchies, fathers were placed in lower positions, and the structure of adolescents’ hierarchies were less differentiated than in the high school samples. Individual differences in the composition of adolescents’ hierarchies were associated with adjustment outcomes. Friends’ placement in higher positions and fathers’ exclusion from or placement in quaternary positions was associated with increased behavior problems. Findings demonstrate that the IPI provides a measure of adolescents’ attachment hierarchies that is sensitive to developmental stage and individual differences. PMID:22545000

Primary gastric mucosa associated lymphoid tissue lymphoma: Clinical data predicted treatment outcome

PubMed Central

Todorovic, Milena; Balint, Bela; Jevtic, Miodrag; Suvajdzic, Nada; Ceric, Amela; Stamatovic, Dragana; Markovic, Olivera; Perunicic, Maja; Marjanovic, Slobodan; Krstic, Miodrag

2008-01-01

AIM: To determine clinical characteristics and treatment outcome of gastric lymphoma after chemotherapy and immuno-chemotherapy. METHODS: Thirty four patients with primary gastric mucosa associated lymphoid tissue (MALT) lymphoma (Ann Arbor stages I to IV) were enrolled. All had upper gastric endoscopy, abdominal ultrasonography, CT and H pylori status assessment (histology and serology). After anti-H pylori treatment and initial chemotherapy, patients were re-examined every 4 mo. RESULTS: Histological regression of the lymphoma was complete in 22/34 (64.7%) and partial in 9 (26.5%) patients. Median follow up time for these 31 responders was 60 mo (range 48-120). No regression was noted in 3 patients. Among the 25 (73.5%) H pylori positive patients, the eradication rate was 100%. CONCLUSION: Using univariate analysis, predictive factors for overall survival were international prognostic index (IPI) score, hemoglobin level, erythrocyte sedimentation rate (ESR), and platelet numbers (P < 0.005). In addition to this, Cox proportion hazard model differentiate IPI score, ESR, and platelets as predictors of survival. PMID:18416467

Research-based Curricula in the Context of 21st Century Data Science

NASA Astrophysics Data System (ADS)

Fox, P. A.

2017-12-01

When the Informatics revolution began again a little more than 10 years ago (longer for bio-informatics) geosciences (or Earth and Space Sciences) was paying attention via international attention from the Electronic Geophysical Year (eGY) and related endeavours (IPY, IYPE, IHY). The research agenda was in the spotlight, or moreso what Earth and Space Science informatics, cast in emergent escience or cyber-infrastructures, could benefit from was the main focus of attention and funding. At the time almost all "Xinformatics" efforts were novel in their discipline or traditionally defined. However, a broader research and education agenda was clearly needed. At the same time, a much more cross-disciplinary field; data science emerged. In this presentation, we relate the development, delivery and assessment of research oriented informatics, data science and their specializations into geoscience education in generak and as undertaken at RPI over the last nine years. We conclude with a longitudinal view of the impacts on career paths in the 21st century

Teacher perspectives and the psychosocial climate of the classroom in a traditional BSN program.

PubMed

Rowbotham, Melodie A

2010-01-01

Developing and implementing a positive psychosocial environment should be one of the main responsibilities of educators. As educators influence the climate, learning is enhanced or hindered. Therefore educators need to understand their own teaching perspectives and how they in turn influence the classroom. Data were collected from nurse educators and BSN nursing students. The relationship between faculty teaching perspectives and the students' perceptions of the learning environment was examined. The data collection tool used to measure the educators' perspective was the Instructional Perspective Inventory (IPI), and to measure the students' perspective was the Adult Classroom Environment Scale (ACES). A MANCOVA was used to determine the relationship and significant differences between educators' and students' perspectives. The results indicated that the teachers in the high group of teacher responsiveness had students who reported greater teacher support, time on task, focus, organization, clarity of subject content, involvement, and satisfaction.

Predictive value of pretreatment positron emission tomography/computed tomography in patients with newly diagnosed extranodal natural killer/T-cell lymphoma.

PubMed

Bai, Bing; Huang, Hui-Qiang; Cai, Qi-Chun; Fan, Wei; Wang, Xiao-Xiao; Zhang, Xu; Lin, Ze-Xiao; Gao, Yan; Xia, Yun-Fei; Guo, Ying; Cai, Qing-Qing; Jiang, Wen-Qi; Lin, Tong-Yu

2013-03-01

The role of (18)Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) in extranodal natural killer/T-cell lymphoma (ENKL) is not well established. This study aimed to investigate the prognostic role of the pretreatment maximum standardized uptake value (SUV(max)) on PET/CT in patients with newly diagnosed ENKL. Among 364 consecutive patients with newly diagnosed ENKL, 81 patients were included and reviewed. The impact of SUV(max) on survival and the relationship between SUV(max) and other clinicopathological parameters were analyzed. The median SUV(max) was 14.6 (range 2.0-45.4). The optimal cutoff value of SUV(max) to predict overall survival (OS) was 15. Patients with high SUV(max) (SUVmax >15) were associated with bulky disease (P < 0.001), local invasion (P = 0.030), high score of Korean Prognostic Index (KPI, P = 0.046), resistance to primary treatment (P = 0.014), poor OS (P < 0.001), and unfavorable progression-free survival (P < 0.001). With a median follow-up of 25.0 months, the median OS was 63.0 months (range 2.0-99.0 months). Multivariate analyses revealed the following independent prognostic factors for OS: age >60 years (P = 0.001), stage III-IV (P = 0.023), SUV(max) >15 (P = 0.020), and bulky disease (>5 cm) (P = 0.002). By using the SUV(max), patients in most subgroups stratified by the KPI or the International Prognostic Index (IPI) were further discriminated in OS with significant statistical difference. Our results suggest the pretreatment SUV(max) is predictive of prognosis in patients with newly diagnosed ENKL. The SUV(max) may provide additional prognostic information for IPI and KPI.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cai Ling; Sun Yat-sen University Cancer Center, Guangzhou, Guangdong; Stauder, Michael C.

Purpose: Primary bone lymphoma (PBL) represents less than 1% of all malignant lymphomas. In this study, we assessed the disease profile, outcome, and prognostic factors in patients with Stages I and II PBL. Patients and Methods: Thirteen Rare Cancer Network (RCN) institutions enrolled 116 consecutive patients with PBL treated between 1987 and 2008 in this study. Eighty-seven patients underwent chemoradiotherapy (CXRT) without (78) or with (9) surgery, 15 radiotherapy (RT) without (13) or with (2) surgery, and 14 chemotherapy (CXT) without (9) or with (5) surgery. Median RT dose was 40 Gy (range, 4-60). The median number of CXT cyclesmore » was six (range, 2-8). Median follow-up was 41 months (range, 6-242). Results: The overall response rate at the end of treatment was 91% (complete response [CR] 74%, partial response [PR] 17%). Local recurrence or progression was observed in 12 (10%) patients and systemic recurrence in 17 (15%). The 5-year overall survival (OS), lymphoma-specific survival (LSS), and local control (LC) were 76%, 78%, and 92%, respectively. In univariate analyses (log-rank test), favorable prognostic factors for OS and LSS were International Prognostic Index (IPI) score {<=}1 (p = 0.009), high-grade histology (p = 0.04), CXRT (p = 0.05), CXT (p = 0.0004), CR (p < 0.0001), and RT dose >40 Gy (p = 0.005). For LC, only CR and Stage I were favorable factors. In multivariate analysis, IPI score, RT dose, CR, and CXT were independently influencing the outcome (OS and LSS). CR was the only predicting factor for LC. Conclusion: This large multicenter retrospective study confirms the good prognosis of early-stage PBL treated with combined CXRT. An adequate dose of RT and complete CXT regime were associated with better outcome.« less

Evolution of Incubation Models: Evidence from the Italian Incubation Industry

ERIC Educational Resources Information Center

Grandi, Alessandro; Grimaldi, Rosa

2004-01-01

This paper addresses the role of incubators in supporting new venture creation. A mapping of four different types of incubator is proposed: corporate private incubators (CPIs), independent private incubators (IPIs), business innovation centres (BICs) and university business incubators (UBIs). This mapping is exemplified through case studies of one…

77 FR 66863 - Notice of Submission of Proposed Information Collection to OMB Electronic Stakeholder Survey...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-07

... Philanthropic Innovation AGENCY: Office of the Chief Information Officer, HUD. ACTION: Notice. SUMMARY: The proposed information collection requirement described below has been submitted to the Office of Management... presented by HUD's Office for International and Philanthropic Innovation (IPI). The Office for International...

A Comparison of Piagetian Conservation Concepts with Reading Achievement.

ERIC Educational Resources Information Center

Caballero, Jane Alexis

This study involved a comparison of first and second grade students' performance on the Piagetian Task Administration Instrument (PTAI), the Metropolitan Readiness Test (MRT), and the Stanford Achievement Test (SAT) with actual reading achievement measured by placement on the Indiviudally Paced Instruction (IPI) Tracking Card in Reading, which was…

77 FR 52051 - Proposed Information Collection for Public Comment: Electronic Stakeholder Survey-Office for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-28

... and resources by working across public, private, and civil sectors to further HUD's mission. IPI works... alignment of cross-sector resources and ideas. Members of affected public: Individuals. Estimation of the... Collection for Public Comment: Electronic Stakeholder Survey--Office for International and Philanthropic...

Assessing Adolescents' Attachment Hierarchies: Differences across Developmental Periods and Associations with Individual Adaptation

ERIC Educational Resources Information Center

Rosenthal, Natalie L.; Kobak, Roger

2010-01-01

Adolescents' attachment hierarchies were assessed in a sample of 212 high school and 198 college students. The Important People Interview (IPI) differentiated attachment bonds from other supportive or affiliative relationships and indicated that adolescents show a hierarchical ordering of preferences for multiple attachment figures. Differences in…

An Investigation of the Efficiency of Various Observational Procedures.

ERIC Educational Resources Information Center

Kissel, Mary Ann; Yeager, John L.

Several sampling procedures for collecting observational data on student activities were studied in an effort to determine their relative efficiency. The setting was a fifth grade Individually Prescribed Instruction (IPI) mathematics class of thirty-three pupils. A criterion measure was obtained by cumulating the measurements obtained on the…

An International Polar Year Adventure in the Arctic

NASA Astrophysics Data System (ADS)

Wartes, D.

2008-12-01

RAHI, the Rural Alaska Honors Institute at the University of Alaska Fairbanks began in 1983 after a series of meetings between the Alaska Federation of Natives and the University of Alaska, to discuss the retention rates of Alaska Native and rural students. RAHI is a six-week college-preparatory summer bridge program on the University of Alaska Fairbanks campus for Alaska Native and rural high school juniors and seniors. The program's student body is approximately 94 percent Alaska Native. RAHI students take classes that earn them seven to ten college credits, thus giving them a head start on college. Courses include: writing, study skills, desk top publishing, Alaska Native dance or swimming, and a choice of biochemistry, math, business, or engineering. A program of rigorous academic activity combines with social, cultural, and recreational activities to make up the RAHI program of early preparation for college. Students are purposely stretched beyond their comfort levels academically and socially to prepare for the big step from home or village to a large culturally western urban campus. They are treated as honors students and are expected to meet all rigorous academic and social standards set by the program. All of this effort and activity support the principal goal of RAHI: promoting academic success for rural students in college. Over 26 years, 1,200 students have attended the program. Sixty percent of RAHI's alumni have entered four-year academic programs. Over 245 have earned a bachelor's degree, thirty-one have earned master's degrees, and seven have graduated with professional degrees (J.D., Pharm., or M.D.), along with 156 associate degrees and certificates. In looking at the RAHI cohort, removing those students who have not been in college long enough to obtain a degree, 27.3 percent of RAHI alums have received a bachelor's degree. An April 2006 report by the American Institutes for Research through the National Science Foundation found that: Rural Native students in the UA system who participated in RAHI are nearly twice as likely to earn a bachelor's degree, than those who did not attend RAHI. The past two summers, in celebration of the International Polar Year, in collaboration with Ilisagvik College, at the completion of the traditional RAHI program, ten RAHI students flew to Barrow for an additional two weeks of study. Five students participated in an archaeological dig and five students performed research with the Barrow Arctic Science Consortium scientists studying climate change. And another student was the Alaskan delegate to the Students on Ice, a 2-week ship-based adventure in northern Canada. In addition, ten students from Greenland visited the program, with plans to more fully participate next summer. This added dimension to the program has proved successful, allowing the students to compare and contrast between their own countries and indigenous perspectives. Global warming was an issue that was hotly debated, as its effects are so evident in the Polar Regions. In the Arctic, one's life is directly tied to the ice and snow. As the ice disappears and/or changes, the Indigenous people have to adapt. RAHI would like to share with you some of the results of this past summer's IPY activities.

Alaskan Exemplary Program The Rural Alaska Honors Institute (RAHI) A Quarter Century of Success of Educating, Nurturing, and Retaining Alaska Native and Rural Students An International Polar Year Adventure in Barrow

NASA Astrophysics Data System (ADS)

Wartes, D.; Owens, G.

2007-12-01

RAHI, the Rural Alaska Honors Institute, began in 1983 after a series of meetings between the Alaska Federation of Natives and the University of Alaska, to discuss the retention rates of Alaska Native and rural students. RAHI is a six-week college-preparatory summer bridge program on the University of Alaska Fairbanks campus for Alaska Native and rural high school juniors and seniors. The student body is approximately 94 percent Alaska Native. RAHI students take classes that earn them seven to ten college credits, thus giving them a head start on college. Courses include: writing, study skills, desk top publishing, Alaska Native dance or swimming, and a choice of geoscience, biochemistry, math, business, rural development, or engineering. A program of rigorous academic activity combines with social, cultural, and recreational activities to make up the RAHI program of early preparation for college. Students are purposely stretched beyond their comfort levels academically and socially to prepare for the big step from home or village to a large culturally western urban campus. They are treated as honors students and are expected to meet all rigorous academic and social standards set by the program. All of this effort and activity support the principal goal of RAHI: promoting academic success for rural students in college. Over 25 years, 1,200 students have attended the program. Sixty percent of the RAHI alumni have entered four-year academic programs. Over 230 have earned a bachelors degree, twenty-nine have earned masters degrees, and seven have graduated with professional degrees (J.D., Ph.D., or M.D.), along with 110 associate degrees and certificates. In looking at the RAHI cohort, removing those students who have not been in college long enough to obtain a degree, 27.3 percent of RAHI alums have received a bachelors degree. An April 2006 report by the American Institutes for Research through the National Science Foundation found that: Rural Native students in the UA system who participated in RAHI are nearly twice as likely to earn a bachelors degree, than those who did not attend RAHI. This summer, in celebration of the International Polar Year, in collaboration with Ilisagvik College, at the completion of the traditional RAHI program, ten RAHI students flew to Barrow for an additional two weeks of study. Five students participated in an archaeological dig and five students performed research with the Barrow Arctic Science Consortium scientists studying climate change. In addition, ten students from Greenland visited the program, with plans to more fully participate next summer. This added dimension to the program has proved successful, allowing the students to compare and contrast between their own countries and indigenous perspectives. Global warming was an issue that was hotly debated, as its effects are so evident in the Polar Regions. In the Arctic, life is directly tied to the ice and snow. As the ice disappears and/or changes, the Indigenous people have to adapt. RAHI would like to share with you some of the results of this past summers IPY activities.

Pan-Arctic TV Series on Inuit wellness: a northern model of communication for social change?

PubMed

Johnson, Rhonda; Morales, Robin; Leavitt, Doreen; Carry, Catherine; Kinnon, Dianne; Rideout, Denise; Clarida, Kath

2011-06-01

This paper provides highlights of a utilization-focused evaluation of a collaborative Pan-Arctic Inuit Wellness TV Series that was broadcast live in Alaska and Canada in May 2009. This International Polar Year (IPY) communication and outreach project intended to (1) share information on International Polar Year research progress, disseminate findings and explore questions with Inuit in Alaska, Canada and Greenland; (2) provide a forum for Inuit in Alaska, Canada and Greenland to showcase innovative health and wellness projects; (3) ensure Inuit youth and adult engagement throughout; and (4) document and reflect on the overall experience for the purposes of developing and "testing" a participatory communication model. Utilization-focused formative evaluation of the project, with a focus on overall objectives, key messages and lessons learned to facilitate program improvement. Participant observation, surveys, key informant interviews, document review and website tracking. Promising community programs related to 3 themes - men's wellness, maternity care and youth resilience - in diverse circumpolar regions were highlighted, as were current and stillevolving findings from ongoing Arctic research. Multiple media methods were used to effectively deliver and receive key messages determined by both community and academic experts. Local capacity and new regional networks were strengthened. Evidence-based resources for health education and community action were archived in digital formats (websites and DVDs), increasing accessibility to otherwise isolated individuals and remote communities. The Pan-Arctic Inuit Wellness TV Series was an innovative, multi-dimensional communication project that raised both interest and awareness about complex health conditions in the North and stimulated community dialogue and potential for increased collaborative action. Consistent with a communication for social change approach, the project created new networks, increased motivation to act and provided new tools to do so, and increased local community involvement and "voice" in the discussion and dissemination of successful strategies to promote Inuit wellness.

School-based prevalence of intestinal parasitic infections and associated risk factors in rural communities of Sana'a, Yemen.

PubMed

Al-Mekhlafi, Abdulsalam M; Abdul-Ghani, Rashad; Al-Eryani, Samira M; Saif-Ali, Reyadh; Mahdy, Mohammed A K

2016-11-01

Yemen is a developing country overwhelmed with a triad of poverty, diseases and social conflicts. Moreover, the majority of its population live in rural communities and suffer from intestinal parasitic infections (IPIs). Therefore, the present school-based, cross-sectional survey aimed to detect the prevalence of such infections and associated risk factors among schoolchildren in the rural communities of Bani Alharith, Hamdan and Bani Hushaysh districts of Sana'a, north of Yemen. Socio-demographic data and certain behavioral risk factors as well as stool samples were collected from 1218 schoolchildren from ten randomly schools in the study area. Fresh stool samples were examined for parasites by direct saline and iodine preparations and after concentration with formol-ether technique. The overall prevalence of IPIs was 54.8%, with a higher frequency of protozoal than helminthic infections (37.6 vs. 17.2%, respectively). Parasite species recovered were Entameba histolytica (21.5%), Giardia lamblia (16.1%), Ascaris lumbricoides (8.3%), Hymenolepis nana (5.3%), Schistosoma mansoni (2.6%), Trichuris trichiura (0.5%) and Enterobius vermicularis (0.4%). Univariate analysis showed that the male gender and illiteracy of fathers and/or mothers were the socio-demographic factors significantly associated with higher infection rates. The illiteracy of mothers was also confirmed as an independent risk factor by multivariable analysis. On the other hand, not washing hands before eating, not washing fruits and vegetables before consumption, eating uncovered food and not clipping fingernails were the risk behaviors significantly associated with higher infection rates, with the last three ones being confirmed as independent risk factors. Therefore, control measures should include regular treatment of protozoal infections and deworming of schoolchildren, promotion of hygiene in rural schools through health education programs, regular inspection of schoolchildren for personal hygiene practices and the provision of a healthy school infrastructure. Copyright © 2016 Elsevier B.V. All rights reserved.

The Association of Polar Early Career Scientists (APECS): A Model for the Professional Development of Scientists (Invited)

NASA Astrophysics Data System (ADS)

Baeseman, J. L.; Apecs Leadership Team

2010-12-01

Efforts like the International Polar Year 2007-2008 (IPY) have helped to increase research efforts as well as enhancing the integration of education and outreach into research projects and developing the next generation of researchers. One of the major legacies of the IPY was the creation of the Association of Polar Early Career Scientists (APECS), which was developed in 2006 by young researchers and focuses on helping each other develop the skills needed for successful careers in research by working with senior mentors. APECS is an international and interdisciplinary organization of over 2000 early career researchers and educators with interests in the Polar Regions and the wider cryosphere from 45 countries. APECS aims to stimulate interdisciplinary and international research collaborations, and develop effective future leaders in polar research, education and outreach. This is achieved by - Facilitating international and interdisciplinary networking opportunities to share ideas and experiences and to develop new research directions and collaborations, - Providing opportunities for professional career development for both academic and alternative research professions, and - Promoting education and outreach as an integral component of polar research and to stimulate future generations of polar researchers. Since its inception, APECS has strived to develop a strong network of partnerships with senior international organizations and scientific bodies to provide career development opportunities for young researchers. These partnerships have led to early-career representation on science planning bodies at an international level, the mandate of early career researchers serving as co-chairs at science conferences, the development of a mentorship program, field schools and techniques workshops, mentor panel discussions at conferences and increased funding for young researchers to attend conferences. APECS has also worked with an international teachers network to develop “Polar Science and Global Climate: An International Resource Guide for Teachers and Researchers” which includes tips and tricks for scientists in communicating their research effectively. Because of its international membership, APECS used the internet as an effective tool to develop skills through a career development webinar series, literature discussion forum, and a virtual poster session where researchers can continue to present their research long after a conference poster session ends. These programs not only serve as ways for young researchers to develop their research, they also serve to provide leadership training to the many individuals who plan these activities and creates a strong sense of community across disciplinary and national boarders. The tools APECS has developed can be used to train the next generation of researchers in any field. But perhaps what is more important are the lessons learned from nurturing the organization to create a strong community of early career and senior researchers helping and motivating each other to improve and stay connected to research careers. This presentation will demonstrate how a young researcher driven effort can become an important and crucial component of any field of research on both the national and international level.

Impact of drought on surface albedo in Canadian Prairie observed from Terra- MODIS

NASA Astrophysics Data System (ADS)

Luo, Y.; Trishchenko, A. P.; Wang, S.; Khlopenkov, K. V.

2009-05-01

A new technology was developed at the Canada Centre for Remote Sensing (CCRS) for generating Canada wide clear-sky surface albedo data based on observations from MODIS sensor onboard TERRA satellite. The data include all seven MODIS land bands (B1-B7) mapped at 250m spatial resolution and 10-day temporal interval from year 2000 through 2008. The new product presents an important spatial enhancement as well as an improved retrieval of water fraction and snow characteristics relative to the standard MODIS archival products. The regional data for the entire Canadian Prairie region are extracted and aggregated for different ecozones, such as north to south, the boreal transition, aspen parkland, moist mixed grassland, and mixed grassland etc. The preliminary results indicate that in comparison to normal summer conditions (2006-2008), the albedo for the drought years (2000-2003) summer increases up to 20 percent in the visible band (B1) and decreases as low as 10 percent in the near infrared band (B2). In the shortwave infrared band (B6) where a large absorption by leaf water occurs, the albedo increases as much as 15 percent for the drought years due to less leaf water content. The derived Normalized Difference Vegetation Index (NDVI), which represents a density of healthy vegetation, drops dramatically (up to 30 percent) for the drought period of 2000-2003. Among the different ecozones, the grassland shows the largest response to droughts while the boreal zone shows the least. Further applications of this product include mapping of snow cover (fraction and grain size), the fraction of absorbed photo-synthetically active radiation (fAPAR), ecosystem productivity, water and energy budget, as well as impact of various disturbances, such as wildfires, and long term climate induced trends. This work was conducted at the Canada Centre for Remote Sensing (CCRS), Earth Sciences Sector of the Department of Natural Resources Canada as part of the Project J35 of the Program on "Enhancing Resilience in a Changing Climate". This work was also supported by the Canadian Space Agency under the Government Related Initiative Program (GRIP) and the Canadian IPY program. The MODIS data files were acquired from the NASA Distributed Data Archive Center (DAAC).

Antarctica: A Keystone in a Changing World--Online Proceedings for the Tenth International Symposium on Antarctic Earth Sciences. Santa Barbara, California, U.S.A.--August 26 to September 1, 2007

USGS Publications Warehouse

Cooper, Alan; Raymond, Carol; ,

2007-01-01

Overview: The International Symposium on Antarctic Earth Sciences (ISAES) is held once every four years to provide an international forum for presenting research results and new ideas and for planning future Antarctic geoscience research projects. This Tenth ISAES coincides with the International Polar Year (IPY; 50th Anniversary of the International Geophysical Year) and has been structured to showcase the great breadth of geoscience research being done in Antarctic regions by more than more than 100 institutions located in over 30 countries. The science program of the Symposium encompasses six broad themes that cover key topics on evolution and interactions of the geosphere, cryosphere and biosphere and their cross-linkages with past and historic paleoclimates. Emphasis is also on deciphering the climate records in ice cores, geologic cores, rock outcrops and those inferred from climate models. New technologies for the coming decades of geoscience data collection are also highlighted. Ten keynote presentations at the symposium outline the foundation for the research sessions of the symposium and the structure of the Online Proceedings and Proceedings Book for the Tenth ISAES. The ISAES is traditionally a cornerstone meeting for the Scientific Committee on Antarctic Research (SCAR). In recognition of the Tenth ISAES being held in the U.S. for the first time in 30 years and during IPY, the publication of the symposium proceedings is being handled as a special collaborative effort of the U.S. National Science Foundation, the U.S. Geological Survey, The National Academies Polar Research Board and The National Academies Press. The National Academies Polar Research Board oversees the activities of SCAR in the U.S. Special attention has been directed at publication formats for the symposium, to expedite the open and wide sharing of mature and preliminary research results presented in talks and posters at the Tenth ISAES. All symposium presentations are documented by a short Summary printed in the Symposium Program Booklet and either a short research paper or an extended abstract. The research papers and extended abstracts are compiled in this Online Proceedings and are replicated on a DVD-ROM that is placed in the back of the Tenth ISAES Proceedings Book. The Proceedings Book has printed versions of the keynote talks and an overview paper of the symposium. The short research papers and extended abstracts have been handled differently. Research papers present mature research results and syntheses. They have been peer-reviewed using standard journal procedures. Following revisions and acceptances by co-editors, the papers have been formatted for publication and proofread by authors. Each paper has been assigned a Digital Object Identification (DOI) number and separate html link, and posted online (as part of this USGS Open-File Report series) to ensure open and wide access to the research results. Extended abstracts focus on preliminary research results and have not been peer reviewed. They have had only minimal editorial review and revision. Authors have formatted and proofread their papers. Extended abstracts were not given DOI numbers and are included together in a separate chapter of this online Proceedings. USGS publications staff and Stanford-student editorial assistants indexed and compiled the PDF versions of the short research papers and extended abstracts for inclusion in this online Proceedings. USGS staff created the master DVD-ROM that contains a replica of the Online Proceedings for the Tenth ISAES, and provided the DVD-ROM copies that are included in the Tenth ISAES Proceedings Book published by The National Academies Press in the U.S. A team of more than 25 co-editors coordinated with the numerous authors and peer reviewers in handling the many research papers and extended abstracts that are included herein. Handling the large volume of short papers and extended abstracts, getting most of them onli

The Likelihood of Use of Social Power Strategies by School Psychologists when Consulting with Teachers

ERIC Educational Resources Information Center

Wilson, Kristen E.; Erchul, William P.; Raven, Bertram H.

2008-01-01

The Interpersonal Power Inventory (IPI) has been applied previously to investigate school psychologists engaged in problem-solving consultation with teachers concerning students having various learning and adjustment problems. Relevant prior findings include (a) consultants and teachers both perceive soft power strategies as more effective than…

CHEMOSENSORY ATTRACTION OF ZOOSPORES OF THE ESTUARINE DINOFLAGELLATES, PFIESTERIA PISCICIDA AND P. SHUMWAYAE, TO FINFISH MUCUS AND EXCRETA. (R825551)

EPA Science Inventory

Toxic strains of the estuarine dinoflagellates, Pfiesteria piscicida and P. shumwayae, can cause fish death and disease, whereas other estuarine `lookalike' species such as cryptoperidiniopsoids have not been ichthyotoxic under ecologically rel...

Anti-PD-L1 efficacy can be enhanced by inhibition of myeloid derived suppressor cells with a selective inhibitor of PI3Kδ/γ

PubMed Central

Davis, Ruth J.; Moore, Ellen C.; Clavijo, Paul E.; Friedman, Jay; Cash, Harrison; Chen, Zhong; Silvin, Chris; Van Waes, Carter; Allen, Clint

2017-01-01

Checkpoint inhibitors are relatively inefficacious in head and neck cancers, despite an abundance of genetic alterations and a T cell-inflamed phenotype. One significant barrier to efficacy may be the recruitment of myeloid-derived suppressor cells (MDSC) into the tumor microenvironment. Here we demonstrate functional inhibition of MDSC with IPI-145, an inhibitor of PI3Kδ and PI3Kγ isoforms which enhances responses to PD-L1 blockade. Combination therapy induced CD8+ T lymphocyte-dependent primary tumor growth delay and prolonged survival only in T cell-inflamed tumor models of head and neck cancers. However, higher doses of IPI-145 reversed the observed enhancement of anti-PD-L1 efficacy due to off-target suppression of the activity f tumor-infiltrating T lymphocytes. Together, our results offer a preclinical proof of concept for the low dose use of isoform-specific PI3Kδ/γ inhibitors to suppress MDSC to enhance responses to immune checkpoint blockade. PMID:28364000

DynPeak: An Algorithm for Pulse Detection and Frequency Analysis in Hormonal Time Series

PubMed Central

Vidal, Alexandre; Zhang, Qinghua; Médigue, Claire; Fabre, Stéphane; Clément, Frédérique

2012-01-01

The endocrine control of the reproductive function is often studied from the analysis of luteinizing hormone (LH) pulsatile secretion by the pituitary gland. Whereas measurements in the cavernous sinus cumulate anatomical and technical difficulties, LH levels can be easily assessed from jugular blood. However, plasma levels result from a convolution process due to clearance effects when LH enters the general circulation. Simultaneous measurements comparing LH levels in the cavernous sinus and jugular blood have revealed clear differences in the pulse shape, the amplitude and the baseline. Besides, experimental sampling occurs at a relatively low frequency (typically every 10 min) with respect to LH highest frequency release (one pulse per hour) and the resulting LH measurements are noised by both experimental and assay errors. As a result, the pattern of plasma LH may be not so clearly pulsatile. Yet, reliable information on the InterPulse Intervals (IPI) is a prerequisite to study precisely the steroid feedback exerted on the pituitary level. Hence, there is a real need for robust IPI detection algorithms. In this article, we present an algorithm for the monitoring of LH pulse frequency, basing ourselves both on the available endocrinological knowledge on LH pulse (shape and duration with respect to the frequency regime) and synthetic LH data generated by a simple model. We make use of synthetic data to make clear some basic notions underlying our algorithmic choices. We focus on explaining how the process of sampling affects drastically the original pattern of secretion, and especially the amplitude of the detectable pulses. We then describe the algorithm in details and perform it on different sets of both synthetic and experimental LH time series. We further comment on how to diagnose possible outliers from the series of IPIs which is the main output of the algorithm. PMID:22802933

Combined varenicline and naltrexone treatment reduces smoking topography intensity in heavy-drinking smokers.

PubMed

Roche, Daniel J O; Bujarski, Spencer; Hartwell, Emily; Green, ReJoyce; Ray, Lara A

2015-07-01

Heavy drinking smokers constitute a distinct sub-population of smokers for whom traditional smoking cessation therapies may not be effective. Recent evidence suggested that combined varenicline (VAR) and naltrexone (NTX) therapy may be more efficacious than either monotherapy alone in reducing smoking and drinking-related behavior in this population. The manner in which individuals smoke a cigarette (i.e., smoking topography) may be predictive of smoking cessation outcomes, yet the effects of smoking pharmacotherapies on puffing behavior have not been thoroughly examined. Therefore, the current double-blind medication study examined the effects of VAR alone (1mg BID), low dose NTX alone (25mg QD), the combination of VAR+NTX, and placebo on smoking topography measures in heavy drinking, non-treatment seeking daily smokers (n=120). After a 9-day titration period, participants completed a laboratory session in which they smoked their first cigarette of the day using a smoking topography device following 12h of nicotine abstinence and consumption of an alcoholic beverage (BrAC=0.06g/dl). The primary measures were puff count, volume, duration, and velocity and inter-puff interval (IPI). Independent of medication group, puff velocity and IPI increased, while puff volume and duration decreased, over the course of the cigarette. The active medication groups, vs. the placebo group, had significantly blunted puff duration and velocity slopes over the course of the cigarette, and this effect was particularly evident in the VAR+NTX group. Additionally, the VAR+NTX group demonstrated lower average IPI than the monotherapy groups and lower average puff volume than all other groups. These results suggest that smoking pharmacotherapies, particularly the combination of VAR+NTX, alter smoking topography in heavy drinking smokers, producing a pattern of less intense puffing behavior. As smoking topography has been predictive of the ability to quit smoking, future studies should examine how smoking pharmacotherapies' effects on puffing behavior relate to smoking cessation outcomes. Copyright © 2015. Published by Elsevier Inc.

Combined Varenicline and naltrexone treatment reduces smoking topography intensity in heavy-drinking smokers

PubMed Central

Roche, Daniel J.O.; Bujarski, Spencer; Hartwell, Emily; Green, ReJoyce; Ray, Lara A.

2015-01-01

Heavy drinking smokers constitute a distinct sub-population of smokers for whom traditional smoking cessation therapies may not be effective. Recent evidence suggested that combined varenicline (VAR) and naltrexone (NTX) therapy may be more efficacious than either monotherapy alone in reducing smoking and drinking-related behavior in this population. The manner in which individuals smoke a cigarette (i.e., smoking topography) may be predictive of smoking cessation outcomes, yet the effects of smoking pharmacotherapies on puffing behavior have not been thoroughly examined. Therefore, the current double-blind medication study examined the effects of VAR alone (1mg BID), low dose NTX alone (25mg QD), the combination of VAR+NTX, and placebo on smoking topography measures in heavy drinking, non-treatment seeking daily smokers (n=120). After a 9-day titration period, participants completed a laboratory session in which they smoked their first cigarette of the day using a smoking topography device following 12-hrs of nicotine abstinence and consumption of an alcoholic beverage (BrAC = 0.06 g/dl). The primary measures were puff count, volume, duration, and velocity and inter-puff interval (IPI). Independent of medication group, puff velocity and IPI increased, while puff volume and duration decreased, over the course of the cigarette. The active medication groups, vs. the placebo group, had significantly blunted puff duration and velocity slopes over the course of the cigarette, and this effect was particularly evident in the VAR+NTX group. Additionally, the VAR+NTX group demonstrated lower average IPI than the monotherapy groups and lower average puff volume than all other groups. These results suggest that smoking pharmacotherapies, particularly the combination of VAR+NTX, alter smoking topography in heavy drinking smokers, producing a pattern of less intense puffing behavior. As smoking topography has been predictive of the ability to quit smoking, future studies should examine how smoking pharmacotherapies’ effects on puffing behavior relate to smoking cessation outcomes. PMID:25933795

Genomic and Transcriptomic Analyses of Indole-3-Acetic Acid Biosynthesis in Diatoms

NASA Astrophysics Data System (ADS)

Lim, R.; Armbrust, V.

2016-02-01

Indole-3-acetic acid (IAA) is a major plant growth hormone and a common mediator of plant-bacterial interactions. Recently, IAA has also been found to play a role in interactions between diatoms and bacteria, with IAA production by an associated Sulfitobacter leading to increased growth rates in the marine diatom Pseudo-nitzschia multiseries. It is unclear, however, if diatoms themselves are able to synthesize IAA and whether this capability is widespread throughout Bacillariophyta. Four major tryptophan-dependent IAA biosynthesis pathways have been identified in plants and bacteria, each denoted by the first intermediate downstream of tryptophan: the indole-3-pyruvate (IPyA), tryptamine (TAM), indole-3-acetaldoxime (IAOx) and indole-3-acetamide (IAM) pathways. To investigate the possibility of IAA biosynthesis in diatoms, we first analyzed publicly available genomes of raphid pennates P. multiseries, Phaeodactylum tricornutum, Fragilariopsis cylindrus and centric Thalassiosira pseudonana for potential homologs to plant and bacterial IAA biosynthesis genes. The P. multiseries, F. cylindrus and P. tricornutum genomes encode downstream enzymes for bacterial TAM and IAM and plant IPyA pathways. The more evolutionarily ancient T. pseudonana encodes one TAM enzyme in its genome. To investigate the potential distribution of these pathways more broadly, we surveyed the transcriptomes of 11 diatom species that include representatives from all four Bacillariophyta classes. Datasets used were sequenced as part of the Marine Microbial Eukaryote Transcriptome Sequencing Project (MMETSP) and obtained from cultures maintained axenically. Transcripts associated with the TAM pathway were most frequently detected, with potential homologs to required enzymes identified in 10 of the 11 species examined. Transcripts homologous to rate-limiting IPyA enzymes were detected in six species. Only two centric and araphid pennate species expressed transcripts associated with enzymes in the IAM and IAOx pathways. This pattern suggests multiple events of gene loss as the phylum expanded and diversified. Mass spectrometry analyses will be conducted to confirm the production of IAA in axenic cultures of P. pungens, P. multistriata, Skeletonema marinoi and F. cylindrus.

Acceptance Test Data for BWXT Coated Particle Batches 93172B and 93173B—Defective IPyC and Pyrocarbon Anisotropy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunn, John D.; Helmreich, Grant W.; Dyer, John A.

Coated particle batches J52O-16-93172B and J52O-16-93173B were produced by Babcock and Wilcox Technologies (BWXT) as part of the production campaign for the Advanced Gas Reactor Fuel Development and Qualification (AGR) Program’s AGR-5/6/7 irradiation test in the Idaho National Laboratory (INL) Advanced Test Reactor (ATR), but were not used in the final fuel composite. However, these batches may be used as demonstration production-scale coated particle fuel for other experiments. Each batch was coated in a 150-mm-diameter production-scale fluidized-bed chemical vapor deposition (CVD) furnace. Tristructural isotropic (TRISO) coatings were deposited on 425-μm-nominal-diameter spherical kernels from BWXT lot J52R-16-69317 containing a mixture ofmore » 15.5%-enriched uranium carbide and uranium oxide (UCO). The TRISO coatings consisted of four consecutive CVD layers: a ~50% dense carbon buffer layer with 100-μm-nominal thickness, a dense inner pyrolytic carbon (IPyC) layer with 40-μm-nominal thickness, a silicon carbide (SiC) layer with 35-μm-nominal thickness, and a dense outer pyrolytic carbon (OPyC) layer with 40-μm-nominal thickness. The TRISO-coated particle batches were sieved to upgrade the particles by removing over-sized and under-sized material, and the upgraded batches were designated by appending the letter A to the end of the batch number (e.g., 93172A). Secondary upgrading by sieving was performed on the A-designated batches to remove particles with missing or very-thin buffer layers that were identified during previous analysis of the individual batches for defective IPyC, as reported in the acceptance test data report for the AGR-5/6/7 production batches [Hunn et al. 2017b]. The additionally-upgraded batches were designated by appending the letter B to the end of the batch number (e.g., 93172B).« less

24/7 Solar Minimum Polar Cap and Auroral Ion Temperature Observations

NASA Technical Reports Server (NTRS)

Sojka, Jan J.; Nicolls, Michael; van Eyken, Anthony; Heinselman, Craig; Bilitza, Dieter

2011-01-01

During the International Polar Year (IPY) two Incoherent Scatter Radars (ISRs) achieved close to 24/7 continuous observations. This presentation describes their data sets and specifically how they can provide the International Reference Ionosphere (IRI) a fiduciary E- and F-region ionosphere description for solar minimum conditions in both the auroral and polar cap regions. The ionospheric description being electron density, ion temperature and electron temperature profiles from as low as 90 km extending to several scale heights above the F-layer peak. The auroral location is Poker Flat in Alaska at 65.1 N latitude, 212.5 E longitude where the NSF s new Poker Flat Incoherent Scatter Radar (PFISR) is located. This location during solar minimum conditions is in the auroral region for most of the day but is at midlatitudes, equator ward of the cusp, for about 4-8 h per day dependent upon geomagnetic activity. In contrast the polar location is Svalbard, at 78.2 N latitude, 16.0 E longitude where the EISCAT Svalbard Radar (ESR) is located. For most of the day the ESR is in the Northern Polar Cap with a noon sector passage often through the dayside cusp. Of unique relevance to IRI is that these extended observations have enabled the ionospheric morphology to be distinguished between quiet and disturbed geomagnetic conditions. During the IPY year, 1 March 2007 - 29 February 2008, about 50 solar wind Corotating Interaction Regions (CIRs) impacted geospace. Each CIR has a two to five day geomagnetic disturbance that is observed in the ESR and PFISR observations. Hence, this data set also enables the quiet-background ionospheric climatology to be established as a function of season and local time. These two separate climatologies for the ion temperature at an altitude of 300 km are presented and compared with IRI ion temperatures. The IRI ion temperatures are about 200-300 K hotter than the observed values. However, the MSIS neutral temperature at 300 km compares favorably with the quiet-background in temperature, both in magnitude and climatology.

EUROANDRILL Initiative

NASA Astrophysics Data System (ADS)

Florindo, Fabio; Steering Committee, Euroandrill

2010-05-01

EuroANDRILL is a new initiative to create a European network with the goal to increase future involvement of European countries in the ANDRILL [ANtarctic geological DRILLing] Programme. Antarctica has been heavily glaciated for approximately 34 million years, but its ice sheets have fluctuated considerably and are one of the major driving forces for changes in climate throughout the Cenozoic Era. The spatial scale and temporal pattern of these fluctuations is subject to considerable debate. Understanding the response of large ice masses to climatic forcing is of vital importance because ice volume variations drive global sea level changes and also alter the capacity of ice sheets and sea-ice to act as major heat sinks/insulators. It is particularly important to assess the stability of the cryosphere in the face of rising CO2 levels, as modelling of the climate shift from a warm, vegetated Antarctica to a cold, ice-covered state 34 million years ago suggests a powerful greenhouse gas influence. As Antarctica is the major driver of Earth's climate and sea level, much effort has been expended in deriving models of its behaviour. Some of these models have been successfully validated against modern conditions. EuroANDRILL will provide a coherent, integrated platform for European leadership and involvement in the international ANDRILL programme. The coordination and networking provided by EuroANDRILL will seek to expand participation by European nations, institutions, and individual scientists in the study of the geologic history of the polar regions and their paleoclimatic significance. During the IPY, ANDRILL has been a highly visible and successful programme. This programme seeks to expand on this legacy beyond the IPY and make these contributions sustainable in the European Research Area through networking of research projects and future planning efforts, which establish Europe as a key player in future polar sediment and rock drilling. EuroANDRILL is set up under the auspices of the European Polar Board (EPB) as a subgroup (EuroANDRILL steering committee (SC)) representing the scientific disciplines and associated technical capacities associated with polar sediment and rock core science. http://www.euroandrill.com/ http://www.esf.org/research-areas/european-polar-board-epb/euroandrill.html http://www.andrill.org/

Four Fourier transform spectrometers and the Arctic polar vortex: instrument intercomparison and ACE-FTS validation at Eureka during the IPY springs of 2007 and 2008

NASA Astrophysics Data System (ADS)

Batchelor, R. L.; Kolonjari, F.; Lindenmaier, R.; Mittermeier, R. L.; Daffer, W.; Fast, H.; Manney, G.; Strong, K.; Walker, K. A.

2010-01-01

The Canadian Arctic Atmospheric Chemistry Experiment Validation Campaigns have been carried out at Eureka, Nunavut (80.05° N, 86.42° W) during the polar sunrise period since 2004. During the International Polar Year (IPY) springs of 2007 and 2008, three ground-based Fourier transform infrared (FTIR) spectrometers were operated simultaneously. This paper presents a comparison of trace gas measurements of stratospherically important species involved in ozone depletion, namely O3, HCl, ClONO2, HNO3 and HF, recorded with these three spectrometers. Total column densities of the gases measured with the new Canadian Network for the Detection of Atmospheric Change (CANDAC) Bruker 125HR are shown to agree to within 3.5% with the existing Environment Canada Bomem DA8 measurements. After smoothing both of these sets of measurements to account for the lower spectral resolution of the University of Waterloo Portable Atmospheric Research Interferometric Spectrometer for the Infrared (PARIS-IR), the measurements were likewise shown to agree with PARIS-IR to within 7%. Concurrent measurements of these gases were also made with the satellite-based Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS) during overpasses of Eureka during these time periods. While one of the mandates of the ACE satellite mission is to study ozone depletion in the polar spring, previous validation exercises have identified the highly variable polar vortex conditions of the spring period to be a challenge for validation efforts. In this work, comparisons between the CANDAC Bruker 125HR and ACE-FTS have been used to develop strict criteria that allow the ground- and satellite-based instruments to be confidently compared. When these criteria are taken into consideration, the observed biases between the ACE-FTS and ground-based FTIR spectrometer are not persistent for both years and are generally insignificant, though small positive biases of ~5%, comparable in magnitude to those seen in previous validation exercises, are observed for HCl and HF in 2007, and negative biases of -15.3%, -4.8% and -1.5% are seen for ClONO2, HNO3 and O3 in 2008.

Association between Anaemia, Iron Deficiency Anaemia, Neglected Parasitic Infections and Socioeconomic Factors in Rural Children of West Malaysia

PubMed Central

Ngui, Romano; Lim, Yvonne Ai Lian; Chong Kin, Liam; Sek Chuen, Chow; Jaffar, Shukri

2012-01-01

Background Given that micronutrient deficiency, neglected intestinal parasitic infections (IPIs) and poor socioeconomic status are closely linked, we conducted a cross-sectional study to assess the relationship between IPIs and nutritional status of children living in remote and rural areas in West Malaysia. Methods/Findings A total of 550 children participated, comprising 520 (94.5%) school children aged 7 to 12 years old, 30 (5.5%) young children aged 1 to 6 years old, 254 (46.2%) boys and 296 (53.8%) girls. Of the 550 children, 26.2% were anaemic, 54.9% iron deficient and 16.9% had iron deficiency anaemia (IDA). The overall prevalence of helminths was 76.5% comprising Trichuris trichiura (71.5%), Ascaris lumbricoides (41.6%) and hookworm infection (13.5%). It was observed that iron deficiency was significantly higher in girls (p = 0.032) compared to boys. Univariate analysis demonstrated that low level of mother's education (OR = 2.52; 95% CI = 1.38–4.60; p = 0.002), non working parents (OR = 2.18; 95% CI = 2.06–2.31; p = 0.013), low household income (OR = 2.02; 95% CI = 1.14–3.59; p = 0.015), T. trichiura (OR = 2.15; 95% CI = 1.21–3.81; p = 0.008) and A. lumbricoides infections (OR = 1.63; 95% CI = 1.04–2.55; p = 0.032) were significantly associated with the high prevalence of IDA. Multivariate analysis confirmed that low level of mother's education (OR = 1.48; 95 CI% = 1.33–2.58; p<0.001) was a significant predictor for IDA in these children. Conclusion It is crucial that a comprehensive primary health care programme for these communities that includes periodic de-worming, nutrition supplement, improved household economy, education, sanitation status and personal hygiene are taken into consideration to improve the nutritional status of these children. PMID:22413027

Monitoring of the Polar Stratospheric Clouds formation and evolution in Antarctica in August 2007 during IPY with the MATCH method applied to lidar data

NASA Astrophysics Data System (ADS)

Montoux, Nadege; David, Christine; Klekociuk, Andrew; Pitts, Michael; di Liberto, Luca; Snels, Marcel; Jumelet, Julien; Bekki, Slimane; Larsen, Niels

2010-05-01

The project ORACLE-O3 ("Ozone layer and UV RAdiation in a changing CLimate Evaluated during IPY") is one of the coordinated international proposals selected for the International Polar Year (IPY). As part of this global project, LOLITA-PSC ("Lagrangian Observations with Lidar Investigations and Trajectories in Antarctica and Arctic, of PSC") is devoted to Polar Stratospheric Clouds (PSC) studies. Indeed, understanding the formation and evolution of PSC is an important issue to quantify the impact of climate changes on their frequency of formation and, further, on chlorine activation and subsequent ozone depletion. In this framework, three lidar stations performed PSC observations in Antarctica during the 2006, 2007, and 2008 winters: Davis (68.58°S, 77.97°E), McMurdo (77.86°S, 166.48°E) and Dumont D'Urville (66.67°S, 140.01°E). The data are completed with the lidar data from CALIOP ("Cloud-Aerosol Lidar with Orthogonal Polarization") onboard the CALIPSO ("Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation") satellite. Lagrangian trajectory calculations are used to identify air masses with PSCs sounded by several ground-based lidar stations with the same method, called MATCH, applied for the first time in Arctic to study the ozone depletion with radiosoundings. The evolution of the optical properties of the PSCs and thus the type of PSCs formed (supercooled ternary solution, nitric acid trihydrate particles or ice particles) could thus be linked to the thermodynamical evolution of the air mass deduced from the trajectories. A modeling with the microphysical model of the Danish Meteorological Institute allows assessing our ability to predict PSCs for various environmental conditions. Indeed, from pressure and temperature evolution, the model allows retrieving the types of particles formed as well as their mean radii, their concentrations and could also simulate the lidar signals. In a first step, a case in August 2007 around 17-18 km, involving the three ground-based lidar stations and CALIOP has been selected. Trajectories with different models (gscf and ecmwf), grids and initializations have been computed to test the robustness of the MATCH. Then the DMI model has been used with these different trajectories to test its ability to reproduce the observations. For a same case, the temperature differences (~2-3 K) between the trajectories have a strong impact on the number density of the particles formed (factor 1000). This case is presented here in detail and a statistical comparison is planned with the numerous MATCH cases identified during the three winters and which involve most of the time two ground-based lidar stations with CALIOP.

U.S. EPA, Pesticide Product Label, ATRA-5, 04/17/1990

EPA Pesticide Factsheets

2011-04-19

... '.. 1.1 I , i: i ":11 ' ~:, (f··.,~r! 11 c~l(n (>:"I.pi 1 I ~:\\rt·.·). yn·lI QlIJ ... For mi x inq instruc:tiorls ~ 5f.·~E:·~ th~~ "t'li xing Instruc.tinn::;" se(:ti(]n of tllis l.abel. ...

Report from the International Permafrost Association: carbon pools in permafrost regions

Treesearch

Peter Kuhry; Chien-Lu Ping; Edward A.G. Schuur; Charles Tarnocai; Sergey Zimov

2009-01-01

The IPA Carbon Pools in Permafrost Regions (CAPP) Project started in 2005, with endorsement of the Earth System Science Partnership (EESP) Global Carbon Project and the World Climate Research Programme (WCRP) Climate and Cryosphere Project. CAPP is also a project of the IPY. The project was launched because there is considerable concern and increased awareness both...

The new ICSU World Data System: Building on the 50 Year Legacy of the World Data Centers

NASA Astrophysics Data System (ADS)

Clark, D. M.; Minster, J.

2008-12-01

The International Council for Science (ICSU) World Data Center (WDC) system was established in 1957 in response to the data needs of the International Geophysical Year (IGY). Its holdings included a wide range of solar, geophysical, environmental, and human dimensions data. The WDC system developed many innovative data management and data exchange procedures and techniques over the last 50 years, which mitigated effectively the impact of global politics on science. The beginning of the 21st century has seen new ICSU requirements for management of large and diverse scientific data from major international programs such as the Group on Earth Observations (GEO) Global Earth Observation Systems of Systems (GEOSS), the International Polar Year (IPY), the Millennium Ecosystems Assessment (MEA), and the Coordinated Energy and Water Cycle Observation Project (CEOP). As a consequence, a completely new ICSU data activity, the World Data System (WDS) is being created which will incorporate the major ICSU data activities including in particular the WDCs and the Federation of Astronomical and Geophysical Data- Analysis Services. Using the legacy of the WDC system, the WDS will place an emphasis on new information technology as applied to modern data management techniques and international data exchange. The new World Data System will support ICSU's enduring mission and objectives, ensuring the long-term stewardship and provision of quality-assessed data and data services to the international science community and other stakeholders. It will have a broader disciplinary and geographic base than the current ICSU networks and be recognized as a world-wide "community of excellence" for data issues. It will use state-of-the-art systems interoperability, international very high bandwidth capabilities and a coordinated focus on topics such as virtual observatories. It will also encourage the establishment of new data centers and services, using modern paradigms for their establishment and using state-of-the-art approaches to global, distributed data management and exchange.

Age-dependent change in urine proteome of healthy individuals

NASA Astrophysics Data System (ADS)

Dobrokhotov, Igor; Liudmila Pastushkova, MRS.; Larina, Irina; Kononikhin, Alexey

It was analyzed the protein composition of urine samples obtained from twenty Russian cosmonauts and thirty-eight healthy volunteers, that have been selected for the experiments simulating the physiological effects of microgravity. The special sample preparation was performed, followed by liquid chromatography-mass spectrometry. Liquid chromatography-mass spectrometry of the minor proteins was performed on a nano-HPLC Agilent 1100 system (Agilent Technologies Inc., USA) in combination with a LTQ-FT Ultra mass spectrometer (Thermo Electron, Germany). List of masses derived peptides and they fragments have used for search and identification of proteins by database IPI-human (international index of protein) using the program Mascot (MS version 2.0.04 , UK) according to the following criteria: 1 - enzyme-trypsin; 2 - peptide tol. ± 5 ppm; 3 - MS / MS tol. 0.5Da. From list of proteins obtained as a result Mascot-search it was selected only those proteins that were identified based on 2 or more peptides with the rating more than 24. Analysis of the list of proteins was performed using software developed in the laboratory of VA Ivanisenko (ICG SB RAS) Age of healthy individuals was ranged from 18 to 54 years. Depending on the age, the data were divided into three groups: those relating to the group of persons under 25 years (youth and mature age 1), 25-40 years (mature age 2) and 40-54 years (mature age 3) It was detected reliable changes in the number of proteins among groups depending of the age. It was found that the minimum number of different proteins were detected in the urine of the group of young patients (under 25 years old) , and the maximum - was observed in the group of middle-aged persons (25 to 40 years). When the proteins were compared according to their molecular mass it was revealed that in the older group (40-54 years ) there is noticeably smaller percentage of high molecular weight proteins than in groups of young and middle aged persons. Thus, proteomic studies of urine samples can detect reliable age differences between groups of subjects, reflecting both age-specific features of processes of protein reabsorption by the kidneys, and the aging process in general.

Energy Crisis In Pakistan

DTIC Science & Technology

2015-12-01

huge shortfall in gas supplies will be unavoidable. In an effort to mitigate this looming threat, the materialization of transnational gas pipeline ...original financing terms, to kick-start the TAPI gas pipeline project. Despite reaching a consensus, the consortium leader’s selection is still pending...is testimony of the government’s institutional, political, and policy inefficiency. Materialization of IPI and TAPI gas pipeline projects will add

How Are Teachers Integrating Technology in K-5 Classrooms? Studying Student Cognitive Engagement Using the Instructional Practices Inventory-Technology (IPI-T) Instrument

ERIC Educational Resources Information Center

Dennis, Larinee B.

2013-01-01

"It is often assumed that changing the classroom by introducing technology will result in better teaching and increased student motivation, which ultimately means more effective student learning experiences" (Donovan, Green, & Hartley, 2010, p. 423). But does it? This is the controversy and debate that surrounds the promise and…

Production of the plant hormone auxin by Salmonella and its role in the interactions with plants and animals

USDA-ARS?s Scientific Manuscript database

The ability of human enteric pathogens to colonize plants and use them as alternate hosts is now well established. Salmonella enterica, similarly to other phytobacteria, appears to be capable of producing the plant hormone auxin (IAA) via IpdC, an indole pyruvate (IPyA) decarboxylase. ipdC is a key ...

Three-Dimensional Gene Map of Cancer Cell Types: Structural Entropy Minimisation Principle for Defining Tumour Subtypes

PubMed Central

Li, Angsheng; Yin, Xianchen; Pan, Yicheng

2016-01-01

In this study, we propose a method for constructing cell sample networks from gene expression profiles, and a structural entropy minimisation principle for detecting natural structure of networks and for identifying cancer cell subtypes. Our method establishes a three-dimensional gene map of cancer cell types and subtypes. The identified subtypes are defined by a unique gene expression pattern, and a three-dimensional gene map is established by defining the unique gene expression pattern for each identified subtype for cancers, including acute leukaemia, lymphoma, multi-tissue, lung cancer and healthy tissue. Our three-dimensional gene map demonstrates that a true tumour type may be divided into subtypes, each defined by a unique gene expression pattern. Clinical data analyses demonstrate that most cell samples of an identified subtype share similar survival times, survival indicators and International Prognostic Index (IPI) scores and indicate that distinct subtypes identified by our algorithms exhibit different overall survival times, survival ratios and IPI scores. Our three-dimensional gene map establishes a high-definition, one-to-one map between the biologically and medically meaningful tumour subtypes and the gene expression patterns, and identifies remarkable cells that form singleton submodules. PMID:26842724

Fin whale song variability in southern California and the Gulf of California.

PubMed

Širović, Ana; Oleson, Erin M; Buccowich, Jasmine; Rice, Ally; Bayless, Alexandra R

2017-08-31

Songs are distinct, patterned sounds produced by a variety of animals including baleen whales. Fin whale songs, which consist of short pulses repeated at regular interpulse intervals (IPIs), have been suggested as a tool to distinguish populations. Fin whale songs were analyzed from data collected from 2000-2012 in Southern California and from 2004-2010 in the Gulf of California using autonomous acoustic recorders. IPIs were measured for each identifiable song sequence during two random days of each month with recordings. Four distinct song types were identified: long doublet, short doublet, long triplet, and short triplet. Long and short doublets were the dominant songs in Southern California, while long and short triplets were dominant in the Gulf of California. An abrupt change in song type occurred in both areas during the monitoring period. We argue that each song type is unique to a population and these changes represent a shift in the primary population in the monitoring area. Occasional temporal and spatial song overlap indicated some exchange or visitation among populations. Fin whales appear to synchronize and gradually modify song rhythm over long time scales. A better understanding of the evolutionary and ecological importance of songs to fin whale populations is needed.

Interaction of Bordetella bronchiseptica and Its Lipopolysaccharide with In Vitro Culture of Respiratory Nasal Epithelium

PubMed Central

Middleton, Andrew M.; Martínez, Nhora; Romero, Stefany; Iregui, Carlos

2013-01-01

The nasal septa of fetal rabbits at 26 days of gestation were harvested by cesarean section of the does while under anesthesia and then exposed to Bordetella bronchiseptica or its lipopolysaccharide (LPS) for periods of 2 and 4 hours. A total of 240 explants were used. The tissues were examined using the Hematoxylin & Eosin technique. Then, semithin sections (0.5 μm) were stained with toluidine blue and examined with indirect immunoperoxidase (IPI) and lectin histochemistry. The most frequent and statistically significant findings were as follows: (1) cell death and increased goblet cell activity when exposed to bacteria and (2) cell death, cytoplasmic vacuolation and infiltration of polymorphonuclear leukocytes when exposed to LPS. The lesions induced by the bacterium were more severe than with LPS alone, except for the cytoplasmic vacuolation in epithelial cells. IPI stained the ciliated border of the epithelium with the bacterium more intensely, while LPS lectin histochemistry preferentially labeled the cytoplasm of goblet cell. These data indicate that B. bronchiseptica and its LPS may have an affinity for specific glycoproteins that would act as adhesion receptors in both locations. PMID:23555071

Analysis of using interpulse intervals to generate 128-bit biometric random binary sequences for securing wireless body sensor networks.

PubMed

Zhang, Guang-He; Poon, Carmen C Y; Zhang, Yuan-Ting

2012-01-01

Wireless body sensor network (WBSN), a key building block for m-Health, demands extremely stringent resource constraints and thus lightweight security methods are preferred. To minimize resource consumption, utilizing information already available to a WBSN, particularly common to different sensor nodes of a WBSN, for security purposes becomes an attractive solution. In this paper, we tested the randomness and distinctiveness of the 128-bit biometric binary sequences (BSs) generated from interpulse intervals (IPIs) of 20 healthy subjects as well as 30 patients suffered from myocardial infarction and 34 subjects with other cardiovascular diseases. The encoding time of a biometric BS on a WBSN node is on average 23 ms and memory occupation is 204 bytes for any given IPI sequence. The results from five U.S. National Institute of Standards and Technology statistical tests suggest that random biometric BSs can be generated from both healthy subjects and cardiovascular patients and can potentially be used as authentication identifiers for securing WBSNs. Ultimately, it is preferred that these biometric BSs can be used as encryption keys such that key distribution over the WBSN can be avoided.

EVOLUTION OF DIVERGENT FEMALE MATING PREFERENCE IN RESPONSE TO EXPERIMENTAL SEXUAL SELECTION

PubMed Central

Debelle, Allan; Ritchie, Michael G; Snook, Rhonda R

2014-01-01

Sexual selection is predicted to drive the coevolution of mating signals and preferences (mating traits) within populations, and could play a role in speciation if sexual isolation arises due to mating trait divergence between populations. However, few studies have demonstrated that differences in mating traits between populations result from sexual selection alone. Experimental evolution is a promising approach to directly examine the action of sexual selection on mating trait divergence among populations. We manipulated the opportunity for sexual selection (low vs. high) in populations of Drosophila pseudoobscura. Previous studies on these experimental populations have shown that sexual selection manipulation resulted in the divergence between sexual selection treatments of several courtship song parameters, including interpulse interval (IPI) which markedly influences male mating success. Here, we measure female preference for IPI using a playback design to test for preference divergence between the sexual selection treatments after 130 generations of experimental sexual selection. The results suggest that female preference has coevolved with male signal, in opposite directions between the sexual selection treatments, providing direct evidence of the ability of sexual selection to drive the divergent coevolution of mating traits between populations. We discuss the implications in the context sexual selection and speciation. PMID:24931497

Forecasting on the total volumes of Malaysia's imports and exports by multiple linear regression

NASA Astrophysics Data System (ADS)

Beh, W. L.; Yong, M. K. Au

2017-04-01

This study is to give an insight on the doubt of the important of macroeconomic variables that affecting the total volumes of Malaysia's imports and exports by using multiple linear regression (MLR) analysis. The time frame for this study will be determined by using quarterly data of the total volumes of Malaysia's imports and exports covering the period between 2000-2015. The macroeconomic variables will be limited to eleven variables which are the exchange rate of US Dollar with Malaysia Ringgit (USD-MYR), exchange rate of China Yuan with Malaysia Ringgit (RMB-MYR), exchange rate of European Euro with Malaysia Ringgit (EUR-MYR), exchange rate of Singapore Dollar with Malaysia Ringgit (SGD-MYR), crude oil prices, gold prices, producer price index (PPI), interest rate, consumer price index (CPI), industrial production index (IPI) and gross domestic product (GDP). This study has applied the Johansen Co-integration test to investigate the relationship among the total volumes to Malaysia's imports and exports. The result shows that crude oil prices, RMB-MYR, EUR-MYR and IPI play important roles in the total volumes of Malaysia's imports. Meanwhile crude oil price, USD-MYR and GDP play important roles in the total volumes of Malaysia's exports.

Three decades of BGR airborne geophysical surveys over the polar regions - a review

NASA Astrophysics Data System (ADS)

Damaske, Detlef

2013-04-01

The Federal Institute for Geosciences and Natural Resources (BGR) has been conducting geological polar research since 1979. A few years later BGR engaged in airborne geophysical projects. Investigation of the lithosphere of the continent and the continental margins was one of the key issues for BGR. Right from the beginning geophysical research was closely associated with the geological activities. The GANOVEX (German Antarctic North Victoria Land Expedition) program combined geological research with geophysical (mainly airborne) investigations. This proved to be a fruitful approach to many of the open questions regarding the tectonic development of the Ross Sea region. Aeromagnetic surveys evolved into a powerful tool for identifying geological structures and following them underneath the ice covered areas - not accessible to direct geological investigations. To achieve this aim it was essential to lay out these surveys with a relatively closely spaced line separation on the expense of covering large areas at the same time. Nevertheless, over many years of continues research areas of more than a just regional extent could be covered. This was, however, only possible through international collaboration. During the first years, working in the Ross Sea area, the cooperation with the US and Italian programs played a significant role, especially the GITARA (German-Italian Aeromagnetic Research in Antarctica) program has to be mentioned. GEOMAUD (Geoscientific Expedition to Dronning Maud Land) and the German-Australian joint venture PCMEGA (Prince Charles Mountains Expedition of Germany & Australia) expanded research activities to the East Antarctic shield area. In the International Polar Year (IPY), BGR played a leading role in the international project AGAP (Antarctica's GAmburtsev Province) as part of the main topic "Venture into Unknown Regions". AGAP was jointly conducted by the USA, Great Britain, Australia, China and Germany. While in the Ross Sea area even smaller scale surveys - getting close to industry standards - targeted specific geological questions, the reconnaissance type of aerogeophysical projects continued in Dronning Maud Land, now in close cooperation with the Alfred-Wegener-Institute (AWI). This very successful cooperation between the two German institutions - both working continuously in the polar regions - was already established in Arctic projects, namely in northern Greenland. Also, since the late 1990's BGR conducted together with Canada airborne surveys as part of PMAP (Polar Margins Aeromagnetic Program), thematically linked to the predominantly geological CASE (Circum Arctic Structural Events) program of BGR. A joint project of GSC (Geological Survey of Canada) and BGR in the Nares Strait was a highlight of combined geological and aeromagnetic research addressing the still widely discussed Wegener fault between Greenland and Ellesmere Island and the extent of tertiary basins in the Nares Strait itself. BGR intends to continue its successful combined geological-geophysical work in both polar regions. The increasing logistic and financial challenges to work in these extreme areas will demand not only a continuation but an intensification of national and international collaboration.

Heliophysics in the United States of America

NASA Astrophysics Data System (ADS)

Smith, R. W.

2006-11-01

jmc@gi.alaska.edu The IHY program extends from the sun to the heliopause, or from the troposphere to the center of the sun, depending on your viewpoint. The US has cooperating observatories, CIPs and interested individuals willing to participate. On the other hand, there has been very little dedicated funding for the event even though NASA now claims a heliophysics program. Seen from the US viewpoint, this disappointment in funding is moderated by the fact that there are several existing programs that are well organized to collect data relevant to IHY needs. These include national programs such as CEDAR, GEM and SHINE as well as international coordinated groups such as CAWSES, eGY and IPY. Funding is adequate in each of these areas. Given that observational activity is funded and planned to happen, the most important remaining need is to communicate and demonstrate our original Universal Processes approach. Our task is to show how the Universal Processes approach adds important synthesis to the scientific process in programs that are happening. Hence we need to be present at workshops organized by CAWSES, CEDAR, GEM and SHINE to make our message relevant and stimulate studies focused on Universal Processes. Equally important is our emphasis on education and outreach. In the US we are planning special summer schools on IHY and special curriculum to be used in middle and high schools. We hope to produce a major documentary movie to air on television. In both outreach and in the arenas of professional science, our main aim is communication and demonstration of the new science of heliophysics.

Polar Gateways Arctic Circle Sunrise Conference 2008, Barrow, Alaska: IHY-IPY Outreach on Exploration of Polar and Icy Worlds in The Solar System

NASA Astrophysics Data System (ADS)

Cooper, John F.; Kauristie, K.; Weatherwax, A. T.; Sheehan, G. W.; Smith, R. W.; Sandahl, I.; Østgaard, N.; Chernouss, S.; Moore, M. H.; Peticolas, L. M.; Senske, D. A.; Thompson, B. J.; Tamppari, L. K.; Lewis, E. M.

2008-09-01

Polar, heliophysical, and planetary science topics related to the International Heliophysical and Polar Years 2007-2009 were addressed during this circumpolar video conference hosted January 23-29, 2008 at the new Barrow Arctic Research Center of the Barrow Arctic Science Consortium in Barrow, Alaska. This conference was planned as an IHY-IPY event science outreach event bringing together scientists and educational specialists for the first week of sunrise at subzero Arctic temperatures in Barrow. Science presentations spanned the solar system from the polar Sun to Earth, Moon, Mars, Jupiter, Saturn, and the Kuiper Belt. On-site participants experienced look and feel of icy worlds like Europa and Titan by being in the Barrow tundra and sea ice environment and by going "on the ice" during snowmobile expeditions to the near-shore sea ice environment and to Point Barrow, closest geographic point in the U.S. to the North Pole. Many science presentations were made remotely via video conference or teleconference from Sweden, Norway, Russia, Canada, Antarctica, and the United States, spanning up to thirteen time zones (Alaska to Russia) at various times. Extensive educational outreach activities were conducted with the local Barrow and Alaska North Slope communities and through the NASA Digital Learning Network live from the "top of the world" at Barrow. The Sun-Earth Day team from Goddard, and a videographer from the Passport to Knowledge project, carried out extensive educational interviews with many participants and native Inupiaq Eskimo residents of Barrow. Video and podcast recordings of selected interviews are available at http://sunearthday.nasa.gov/2008/multimedia/podcasts.php. Excerpts from these and other interviews will be included in a new high definition video documentary called "From the Sun to the Stars: The New Science of Heliophysics" from Passport to Knowledge that will later broadcast on NASA TV and other educational networks. Full conference proceedings are accessible at http://polargateways2008.org/.

Primary Gastrointestinal Lymphoma

PubMed Central

Chen, Yinting; Chen, Yanzhu; Chen, Shaojie; Wu, Lili; Xu, Lishu; Lian, Guoda; Yang, Kege; Li, Yaqing; Zeng, Linjuan; Huang, Kaihong

2015-01-01

Abstract Primary gastrointestinal lymphoma (PGIL) is a rare malignant tumor without standard diagnosis and treatment methods. This study is aimed to systematically analyze its clinical characteristics and draw out an appropriate flow chart of diagnosis and treatment process for PGIL in China. This study retrospectively analyzed the clinicopathological characteristics, diagnostic approaches, prognostic factors, and therapeutic modalities in 415 cases of PGIL in Chinese province of Guangdong. A systematic review was conducted in 118 studies containing 5075 patients to further identify clinical manifestations and mortalities of therapeutic modalities. The most common clinical presentations were abdominal pain and bloody stools. Endoscopic biopsy was an important diagnostic means, and usually more than once to make a definite diagnosis. Retrospective multicenter clinical study showed that younger onset age (<60 years), female, one region involved, one lesion, early stage, International Prognostic Index (IPI ≤1), normal lactate dehydrogenase (LDH), normal albumin, and nonemergency operation were significant prognostic factors for B-cell lymphoma; non-B symptom, tumor restricted to gastric or ileocecal region, one lesion, performance status (PS ≤1), normal LDH, and nonsurgery alone were significant prognostic factors for T-cell lymphoma. Site of origin and IPI were independent prognostic factors for B-cell lymphoma; PS was the independent prognostic factor for T-cell lymphoma. And T-cell lymphoma had worse overall survival (OS) and progression-free survival (PFS) than B-cell lymphoma. Among different therapeutic modalities, chemotherapy alone or combined with surgery showed better OS and PFS than surgery alone for diffuse large B-cell lymphoma (DLBCL) of stage I/II E and T-cell lymphoma. For DLBCL of stage III E/IV and mucosa-associated lymphoid tissue lymphoma, OS and PFS did not differ among different therapeutic groups. In meta-analysis, surgery plus chemotherapy showed lowest mortality. Chemotherapy alone or combined with surgery may be the first-line treatment for DLBCL of stage I/II E and T-cell lymphoma. A flow chart of diagnosis and treatment process for PGIL was approximately drew out. PMID:26632732

Four Fourier transform spectrometers and the Arctic polar vortex: instrument intercomparison and ACE-FTS validation at Eureka during the IPY springs of 2007 and 2008

NASA Astrophysics Data System (ADS)

Batchelor, R. L.; Kolonjari, F.; Lindenmaier, R.; Mittermeier, R. L.; Daffer, W.; Fast, H.; Manney, G.; Strong, K.; Walker, K. A.

2009-11-01

The Canadian Arctic Atmospheric Chemistry Experiment Validation Campaigns have been carried out at Eureka, Nunavut (80.05° N, 86.42° W) during the polar sunrise period since 2004. During the International Polar Year (IPY) springs of 2007 and 2008, three ground-based Fourier transform infrared (FTIR) spectrometers were operated simultaneously. This paper presents a comparison of trace gas measurements of stratospherically important species involved in ozone depletion, namely O3, HCl, ClONO2, HNO3 and HF, recorded with these three spectrometers. Total column densities of the gases measured with the new Canadian Network for the Detection of Atmospheric Change (CANDAC) Bruker 125HR are shown to agree to within 3.5% with the existing Environment Canada Bomem DA8 measurements. After smoothing both of these sets of measurements to account for the lower spectral resolution of the University of Waterloo Portable Atmospheric Research Interferometric Spectrometer for the Infrared (PARIS-IR), the measurements were likewise shown to agree with PARIS-IR to within 7%. Concurrent measurements of these gases were also made with the satellite-based Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS) during overpasses of Eureka during these time periods. While one of the mandates of the ACE satellite mission is to study ozone depletion in the polar spring, previous validation exercises have identified the highly variable polar vortex conditions of the spring period to be a challenge for validation efforts. In this work, comparisons between the CANDAC Bruker 125HR and ACE-FTS have been used to develop strict criteria that allow the ground- and satellite-based instruments to be confidently compared. When these criteria are taken into consideration, there is shown to be no significant bias between the ACE-FTS and ground-based FTIR spectrometer for any of these gases.

Polar Gateways Arctic Circle Sunrise Conference 2008, Barrow, Alaska: IHY-IPY Outreach on Exploration of Polar and Icy Worlds in the Solar System

NASA Technical Reports Server (NTRS)

Cooper, John F.; Kauristie, Kirsti; Weatherwax, Allan T.; Sheehan, Glenn W.; Smith, Roger W.; Sandahl, Ingrid; Ostgaard, Nikolai; Chernouss, Sergey; Thompson, Barbara J.; Peticolas, Laura;

Adaptive Processing Experiment (APE) Phase II

DTIC Science & Technology

1976-05-01

P*T*~--- - ~ q ~ IPY , U.S. DEPARTMENT OF COMMERCE National Technical Information Service t AD/A-027 071 ADAPTIVE PROCESSING EXPERIMENT (APE...4 newsletter service covering the most recentik" research findings in 25 areas of industrial, The weekly w•Nsletter series will keep you...and professional informa- wish. Please request NTIS-PR-186/PCN for tion service provided by NTIS in the Weekly more information. Government Abstracts

Intrinsic and Extrinsic Origins of the Polar Kerr Effect in a Chiral p-WAVE Superconductor

NASA Astrophysics Data System (ADS)

Goryo, Jun

Recently, the measurement of the polar Kerr effect (PKE) in the quasi two-dimensional superconductor Sr2RuO4, which is motivated to observe the chirality of px + ipy-wave pairing, has been reported. We clarify that the PKE has intrinsic and extrinsic (disorder-induced) origins. The extrinsic contribution would be dominant in the PKE experiment.

Acceptance Test Data for the AGR-5/6/7 Irradiation Test Fuel Composite Defective IPyC Fraction and Pyrocarbon Anisotropy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Helmreich, Grant W.; Hunn, John D.; Skitt, Darren J.

Coated particle composite J52R-16-98005 was produced by Babcock and Wilcox Technologies (BWXT) as fuel for the Advanced Gas Reactor Fuel Development and Qualification (AGR) Program’s AGR-5/6/7 irradiation test in the Idaho National Laboratory (INL) Advanced Test Reactor (ATR). This composite was comprised of four coated particle fuel batches J52O-16-93165B (26%), 93168B (26%), 93169B (24%), and 93170B (24%), chosen based on the Quality Control (QC) data acquired for each individual candidate AGR-5/6/7 batch. Each batch was coated in a 150-mm-diameter production-scale fluidized-bed chemical vapor deposition (CVD) furnace. Tristructural isotropic (TRISO) coatings were deposited on 425-μm-nominal-diameter spherical kernels from BWXT Lot J52R-16-69317more » containing a mixture of 15.5%-enriched uranium carbide and uranium oxide (UCO). The TRISO coatings consisted of four consecutive CVD layers: a ~50% dense carbon buffer layer with 100-μm-nominal thickness, a dense inner pyrolytic carbon (IPyC) layer with 40-μm-nominal thickness, a silicon carbide (SiC) layer with 35-μm-nominal thickness, and a dense outer pyrolytic carbon (OPyC) layer with 40-μm-nominal thickness. The TRISO-coated particle batches were sieved to upgrade the particles by removing over-sized and under-sized material, and the upgraded batches were designated by appending the letter A to the end of the batch number (e.g., 93165A). Secondary upgrading by sieving was performed on the A-designated batches to remove particles with missing or very-thin buffer layers that were identified during previous analysis of the individual batches for defective IPyC, as reported in the acceptance test data report for the AGR-5/6/7 production batches [Hunn et al. 2017]. The additionally-upgraded batches were designated by appending the letter B to the end of the batch number (e.g., 93165B).« less

The landsat image mosaic of the Antarctica Web Portal

USGS Publications Warehouse

Rusanowski, C.J.

2007-01-01

People believe what they can see. The Poles exist as a frozen dream to most people. The International Polar Year wants to break the ice (so to speak), open up the Poles to the general public, support current polar research, and encourage new research projects. The IPY officially begins in March, 2007. As part of this effort, the U.S. Geological Survey (USGS) and the British Antarctic Survey (BAS), with funding from the National Science Foundation (NSF), are developing three Landsat mosaics of Antarctica and an Antarctic Web Portal with a Community site and an online map viewer. When scientists are able to view the entire scope of polar research, they will be better able to collaborate and locate the resources they need. When the general public more readily sees what is happening in the polar environments, they will understand how changes to the polar areas affect everyone.

Breaking the Ice Between Reporters and Scientists During IPY

NASA Astrophysics Data System (ADS)

Bentley, M.

2007-12-01

Communicating scientific information to the general public is a challenge. If the story's not about health advice, a major breakthrough or a natural disaster, scientists may be left wondering how to capture the public's attention and convey the importance of their research. This is a particular challenge in the International Polar Year in which the relevant research has global impacts, but is more nuanced than the headline-grabbing threat of melting ice caps. For example, as ANDRILL punches through ice, it's rock the scientists are after. What can a rock core tell us about how ice comes and goes, and what kind of drill can penetrate 20 million years of strata anyway? In this talk, I will describe how scientists can help communicate to journalists - and thereby the public - the importance of polar research, and give examples of how to help make their work compelling and accessible to those outside of a particular circle of expertise. I will use my experience reporting on science and climate change for the BBC to discuss what frustrations journalists have when talking to scientists and what scientists find difficult in talking to reporters.

Technology Insertion (TI)/Industrial Process Improvement (IPI) Task Order Number 1. Data Base Documentation Book for WR-ALC/MANPSB (Sheet Metal)

DTIC Science & Technology

1989-08-14

peel the cover skins using a wood chisel, tin snips, pliars, etc. to remove the skin without damaging the wires or the heating elements. O.5T-.3...called " Banana Boxes" because they are about the same shape and construction as the boxes used to ship bananas . These boxes would be similar to the ones

Intestinal parasitic infections and associated epidemiological drivers in two rural communities of the Bolivian Chaco.

PubMed

Macchioni, Fabio; Segundo, Higinio; Totino, Valentina; Gabrielli, Simona; Rojas, Patricia; Roselli, Mimmo; Paredes, Grover Adolfo; Masana, Mario; Bartoloni, Alessandro; Cancrini, Gabriella

2016-09-30

In 2013 a coproparasitological survey was carried out in two rural communities of the Bolivian Chaco to determine the prevalence of intestinal parasitic infections (IPIs) and to investigate on possible infection drivers through a questionnaire interview. Faecal samples were examined by microscopy. Samples positive for Entamoeba histolytica complex and Blastocystis were molecularly examined to identify the species/subtypes involved. The overall infection rate was 86%, identical in both communities and mostly due to protozoa. Soil-transmitted helminths were detected in <3% of children and adults. The protozoa detected, including Blastocystis subtypes, indicate faecal contamination of the environment by both humans (as confirmed by the presence of Hymenolepis nana) and animals. Nested-PCR identified E. histolytica, thus signalling the possible occurrence of invasive amoebosis. Lack of safe water, environmental contamination, poor sanitation and hygiene, shared by both communities, are the main drivers of IPIs. In addition, unlike gender and socioeconomic factors, childhood (only for some species), crowding and cohabitation with animals proved to be further significant protozoon infection risk factors. These results highlight the need for the promotion of access to clean water, improved sanitation and better hygiene, thus reducing the frequency of preventive chemotherapy for STHs while continuing to monitor the population for possible recrudescence.

Fasting blood glucose is a novel prognostic indicator for extranodal natural killer/T-cell lymphoma, nasal type

PubMed Central

Cai, Q; Luo, X; Liang, Y; Rao, H; Fang, X; Jiang, W; Lin, T; Lin, T; Huang, H

2013-01-01

Background: Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTL) is an aggressive disease with poor prognosis, requiring risk stratification. However, the prognosis of ENKTL is not fully defined and needs supplementation. We hypothesised that fasting blood glucose (FBG) may be a new prognostic factor for ENKTL. Methods: We retrospectively analysed 130 patients newly diagnosed with ENKTL. Results: Both univariate analysis and multivariate analysis revealed that FBG >100 mg dl−1 was associated with a poor outcome. Patients with FBG >100 mg dl−1 at diagnosis had more adverse clinical features, achieved lower complete remission rates (P=0.003) and had worse overall survival (P<0.001) and progression-free survival (P<0.001) compared with low-FBG patients. Measurement of FBG was helpful in differentiating between low-risk patients using the International Prognostic Index (IPI) and Prognosis Index for peripheral T-cell lymphoma (PIT) scoring and patients in a different category using the Korean Prognostic Index (KPI) scores with different survival outcomes (P<0.05). Conclusion: Our data suggest that measuring FBG levels at diagnosis is a novel, independent predictor of prognosis in ENKTL and helps to distinguish low-risk patients with poor survival, and this holds true in patients considered low-risk by IPI, PIT and KPI. PMID:23299534

Evolution of divergent female mating preference in response to experimental sexual selection.

PubMed

Debelle, Allan; Ritchie, Michael G; Snook, Rhonda R

2014-09-01

Sexual selection is predicted to drive the coevolution of mating signals and preferences (mating traits) within populations, and could play a role in speciation if sexual isolation arises due to mating trait divergence between populations. However, few studies have demonstrated that differences in mating traits between populations result from sexual selection alone. Experimental evolution is a promising approach to directly examine the action of sexual selection on mating trait divergence among populations. We manipulated the opportunity for sexual selection (low vs. high) in populations of Drosophila pseudoobscura. Previous studies on these experimental populations have shown that sexual selection manipulation resulted in the divergence between sexual selection treatments of several courtship song parameters, including interpulse interval (IPI) which markedly influences male mating success. Here, we measure female preference for IPI using a playback design to test for preference divergence between the sexual selection treatments after 130 generations of experimental sexual selection. The results suggest that female preference has coevolved with male signal, in opposite directions between the sexual selection treatments, providing direct evidence of the ability of sexual selection to drive the divergent coevolution of mating traits between populations. We discuss the implications in the context sexual selection and speciation. © 2014 The Authors. Evolution published by Wiley Periodicals, Inc. on behalf of The Society for the Study of Evolution.

Anemia among pregnant women in Southeast Ethiopia: prevalence, severity and associated risk factors.

PubMed

Kefiyalew, Filagot; Zemene, Endalew; Asres, Yaregal; Gedefaw, Lealem

2014-11-03

Anemia is a significant public health problem in developing countries, particularly in pregnant women. It may complicate pregnancy, sometimes resulting in tragic outcomes. There is a lack of information on the magnitude of anemia among pregnant women in Southeast Ethiopia. The aim of this study is, therefore, to determine the prevalence of anemia and assess associated factors among pregnant women attending antenatal care (ANC) at Bisidimo Hospital in Southeast Ethiopia. A facility-based cross-sectional study, involving 258 pregnant women, was conducted from March to June 2013. Socio-demographic, medical and obstetric data of the study participants were collected using structured questionnaire. Hemoglobin was measured using a hematology analyzer and faecal specimens were examined to detect intestinal parasites. Anemia in pregnancy was defined as hemoglobin <11 g/dl. Overall, prevalence of anemia was 27.9%, of which 55% had mild anemia. Rural residence (AOR =3.3, 95% CI: 1.5-7.4), intestinal parasitic infection (IPI) (AOR = 2.5, 95% CI: 1.3-4.8) and history of heavy cycle (AOR =2.7, 95% CI: 1.3-1.7) were predictors of anemia. This study showed moderate prevalence of anemia among the pregnant women, with a sizable proportion having severe anemia. Routine testing of pregnant women for IPIs and creating awareness on factors predisposing to anemia is recommended.

Sensor Webs in Digital Earth

NASA Astrophysics Data System (ADS)

Heavner, M. J.; Fatland, D. R.; Moeller, H.; Hood, E.; Schultz, M.

2007-12-01

The University of Alaska Southeast is currently implementing a sensor web identified as the SouthEast Alaska MOnitoring Network for Science, Telecommunications, Education, and Research (SEAMONSTER). From power systems and instrumentation through data management, visualization, education, and public outreach, SEAMONSTER is designed with modularity in mind. We are utilizing virtual earth infrastructures to enhance both sensor web management and data access. We will describe how the design philosophy of using open, modular components contributes to the exploration of different virtual earth environments. We will also describe the sensor web physical implementation and how the many components have corresponding virtual earth representations. This presentation will provide an example of the integration of sensor webs into a virtual earth. We suggest that IPY sensor networks and sensor webs may integrate into virtual earth systems and provide an IPY legacy easily accessible to both scientists and the public. SEAMONSTER utilizes geobrowsers for education and public outreach, sensor web management, data dissemination, and enabling collaboration. We generate near-real-time auto-updating geobrowser files of the data. In this presentation we will describe how we have implemented these technologies to date, the lessons learned, and our efforts towards greater OGC standard implementation. A major focus will be on demonstrating how geobrowsers have made this project possible.

Discrimination between sequential and simultaneous virtual channels with electrical hearing

PubMed Central

Landsberger, David; Galvin, John J.

2011-01-01

In cochlear implants (CIs), simultaneous or sequential stimulation of adjacent electrodes can produce intermediate pitch percepts between those of the component electrodes. However, it is unclear whether simultaneous and sequential virtual channels (VCs) can be discriminated. In this study, CI users were asked to discriminate simultaneous and sequential VCs; discrimination was measured for monopolar (MP) and bipolar + 1 stimulation (BP + 1), i.e., relatively broad and focused stimulation modes. For sequential VCs, the interpulse interval (IPI) varied between 0.0 and 1.8 ms. All stimuli were presented at comfortably loud, loudness-balanced levels at a 250 pulse per second per electrode (ppse) stimulation rate. On average, CI subjects were able to reliably discriminate between sequential and simultaneous VCs. While there was no significant effect of IPI or stimulation mode on VC discrimination, some subjects exhibited better VC discrimination with BP + 1 stimulation. Subjects’ discrimination between sequential and simultaneous VCs was correlated with electrode discrimination, suggesting that spatial selectivity may influence perception of sequential VCs. To maintain equal loudness, sequential VC amplitudes were nearly double those of simultaneous VCs, presumably resulting in a broader spread of excitation. These results suggest that perceptual differences between simultaneous and sequential VCs might be explained by differences in the spread of excitation. PMID:21895094

Discrimination between sequential and simultaneous virtual channels with electrical hearing.

PubMed

Landsberger, David; Galvin, John J

2011-09-01

In cochlear implants (CIs), simultaneous or sequential stimulation of adjacent electrodes can produce intermediate pitch percepts between those of the component electrodes. However, it is unclear whether simultaneous and sequential virtual channels (VCs) can be discriminated. In this study, CI users were asked to discriminate simultaneous and sequential VCs; discrimination was measured for monopolar (MP) and bipolar + 1 stimulation (BP + 1), i.e., relatively broad and focused stimulation modes. For sequential VCs, the interpulse interval (IPI) varied between 0.0 and 1.8 ms. All stimuli were presented at comfortably loud, loudness-balanced levels at a 250 pulse per second per electrode (ppse) stimulation rate. On average, CI subjects were able to reliably discriminate between sequential and simultaneous VCs. While there was no significant effect of IPI or stimulation mode on VC discrimination, some subjects exhibited better VC discrimination with BP + 1 stimulation. Subjects' discrimination between sequential and simultaneous VCs was correlated with electrode discrimination, suggesting that spatial selectivity may influence perception of sequential VCs. To maintain equal loudness, sequential VC amplitudes were nearly double those of simultaneous VCs, presumably resulting in a broader spread of excitation. These results suggest that perceptual differences between simultaneous and sequential VCs might be explained by differences in the spread of excitation. © 2011 Acoustical Society of America

Q-TWiST analysis comparing ipilimumab/dacarbazine vs placebo/dacarbazine for patients with stage III/IV melanoma.

PubMed

Sherrill, B; Wang, J; Kotapati, S; Chin, K

2013-07-09

Study CA184024 was a multinational, randomised, double-blind, phase 3 study comparing ipilimumab/dacarbazine (DTIC) vs placebo/DTIC in patients with untreated stage III/IV melanoma, which showed that ipilimumab significantly improves survival in patients with metastatic melanoma. The objective of this analysis was to compare the quality-adjusted survival experience among patients in this trial. Survival time was partitioned into health states: toxicity, time before progression without toxicity, and relapse until death or end of follow-up. Q-TWiST (quality-adjusted time without symptoms of disease or toxicity of treatment) was calculated as the utility-weighted sum of the mean health state durations. Analyses were repeated over extended follow-up periods. Based on a combination of trial-based and external utility scores, the Q-TWiST difference in this trial was 0.50 months (P=0.0326) favoring ipilimumab after 1 year. The Q-TWiST difference was 1.5 months with 2 years of follow-up (P=0.0091), 2.36 months at 3 years (P=0.005) and 3.28 months at 4 years (P=0.0074). During the first year of study, there was little difference between groups in quality-adjusted survival. However, after 2, 3 and 4 years follow-up for patients with extended survival, the benefits of IPI+DTIC vs PLA+DTIC for advanced melanoma continue to accrue.

A Legacy for IPY: The Global Snowflake Network (GSN) Together With Art and Ice, and Music and Ice; Unique new Features for Science Education.

NASA Astrophysics Data System (ADS)

Wasilewski, P. J.

2007-12-01

The Global Snowflake Network (GSN) is a program that is simultaneously a science program and an education program. When the validation of the procedures (collection and identification of the type of snowflakes and the associated satellite image archive, as a serial record of a storm), is achieved, then the program becomes a scientific resource. This latter is the ultimate goal. That's why NASA has launched the Global Snowflake Network, a massive project that aims to involve the general public to "collect and classify" falling snowflakes. The data will be compiled into a massive database, along with satellite images, that will help climatologists and others who study climate-related phenomena gain a better understanding of wintry meteorology as they track various snowstorms around the globe. A great deal of information about the atmosphere dynamics and cloud microphysics can be derived from the serial collection and identification of the types of snow crystals and the degree of riming of the snow crystals during the progress of a snow storm. Forecasting winter weather depends in part on cloud physics, which deals with precipitation type, and if it happens to be snow- the crystal type, size, and density of the snowflake population. The History of Winter website will host the evolving snow and ice features for the IPY. Type "Global Snowflake Network" into the search engine (such as GOOGLE) and you will receive a demonstration of the operation of the preliminary GSN by the Indigenous community. The expeditions FINNMARK2007 and the POLAR Husky GoNorth 2007 expedition took the complement of Thermochrons with multimedia instructions for the Global Snowflake Network. This approach demonstrates the continuous Thermochron monitoring of expedition temperature and provides otherwise inaccessible snowflake information to NASA and others interested in the Polar region snow. In addition, reindeer herder and Ph.D. student, Inger Marie G. Eira, will incorporate the HOW, GSN thermochrons, snow pit observations, and snowflake identification protocols into her Ph.D. dissertation on snow changes, and reindeer pastures in Northern Norway. SCIENTISTS DISCOVER - ARTISTS INTERPRET - TOGETHER WE CAN OPEN THE EYES OF THE WORLD. This theme of the "Polar Artists "can be reached from the web search. Water ice is one of the most widespread, intriguing, and familiar compounds on the planet, in the solar system, and beyond. On the planet, it falls as snow, forms lacy deposits on winter windows, creates skating surfaces on lakes, gracefully drapes rock cliffs, packs thickly on the polar oceans, and lays even thicker on the ice caps blanketing Greenland and Antarctica. Of the 11 forms of water ice so far identified, only the form found on Earth can provide a "Frizion". Communicating this is part of Polar Artists outreach. We are working with Terje Isungset, from Norway, who creates musical instruments from ice. We will demonstrate how ART and Ice and Music and Ice are presented. In addition to video presentations appearing on YOUTUBE, we are preparing additional live performances of this work.

Implementing SPRINTT [Student Polar Research with IPY National(and International)Teacher Training] in 5th Grade Science

NASA Astrophysics Data System (ADS)

Glass, D. S.

2009-12-01

I implemented the new NSF-funded SPRINTT (Student Polar Research with IPY National (and International) Teacher Training) curriculum with a 5th grade science class. SPRINTT, developed at U.S. Satellite Laboratory, Inc., is a 5-8 week science program teaching 5th through 10th graders to investigate climate change using polar data. The program includes perspectives of both Western scientists and the indigenous Northern population. The course contains three phases: Phase 1 includes content, data interpretation, and hands-on experiments to study Frozen Water, Frozen Land, and Food; Phase 2 (optional) includes further content on specific polar topics; and Phase 3 is a scaffolded research investigation. Before the course, teachers were trained via live webinars. This curriculum capitalizes on children’s innate fascination with our planet’s final frontier and combines it with the politically and scientifically relevant topic of climate change. In 2009, I used SPRINTT with 23 heterogeneous fifth grade students at National Presbyterian School in Washington DC for an environmental science unit. Overall, it was a success. The students met most of the learning objectives and showed enthusiasm for the material. I share my experiences to help other educators and curriculum developers. The Phase 1 course includes earth science (glaciers, sea ice, weather and climate, greenhouse gases, seasons, and human impacts on environments), life science (needs of living things, food and energy transfer, adaptations, and ecosystems and biomes) and physical science (phases of matter). Tailoring the program, I focused on Phase 1, the most accessible material and content, while deemphasizing the more cumbersome Phase 3 online research project. Pre-assessments documented the students’ misconceptions and informed instruction. The investigations were appropriately educational and interesting. For example, students enjoyed looking at environmental factors and their impact on the people in the tale of “Mr. Gambell’s First Winter.” However, some of the online lessons and video clips were boring or presented technical difficulties. Otherwise, the lessons were paced appropriately, followed a coherent progression, and were sensibly organized into the themes of Frozen Water, Frozen Land, and Food. The three hands-on experiments in Phase 1 (melting ice, permafrost model, and looking at food’s origins) were effective. For example, when comparing ice blocks floating in water (sea ice model) or sitting on a rock above water (glacial ice model), students were eager to describe the shape of each block and competed to guess which ice would melt fastest. They took good notes on the procedure, documented their results and summarized a reasonable conclusion. These activities enlivened the curriculum and taught important lessons about experimental design, data collection, models, and classification. Using traditional knowledge as a formal tool for science is another intriguing component of the SPRINTT program. During Phase 3, the research investigation, students collaborated on a series of online authentic research activities (choosing from several high-interest options) then summarized their findings in a web-based formal report. I share the challenges and successes of using SPRINTT.

Incorporating the International Polar Year Into Introductory Geology Laboratories at Ohio State University

NASA Astrophysics Data System (ADS)

Judge, S. A.; Wilson, T. J.

2005-12-01

The International Polar Year (IPY) provides an excellent opportunity for highlighting polar research in education. The ultimate goal of our outreach and education program is to develop a series of modules that are focused on societally-relevant topics being investigated in Antarctic earth science, while teaching basic geologic concepts that are standard elements of school curricula. For example, we envision a university-level, undergraduate, introductory earth science class with the entire semester/quarter laboratory program focused on polar earth science research during the period of the International Polar Year. To attain this goal, a series of modules will be developed, including inquiry-based exercises founded on imagery (video, digital photos, digital core scans), GIS data layers, maps, and data sets available from OSU research groups. Modules that highlight polar research are also suitable for the K-12 audience. Scaleable/grade appropriate modules that use some of the same data sets as the undergraduate modules can be outlined for elementary through high school earth science classes. An initial module is being developed that focuses on paleoclimate data. The module provides a hands-on investigation of the climate history archived in both ice cores and sedimentary rock cores in order to understand time scales, drivers, and processes of global climate change. The paleoclimate module also demonstrates the types of polar research that are ongoing at OSU, allowing students to observe what research the faculty are undertaking in their respective fields. This will link faculty research with student education in the classroom, enhancing learning outcomes. Finally, this module will provide a direct link to U.S. Antarctic Program research related to the International Polar Year, when new ice and sedimentary rock cores will be obtained and analyzed. As a result of this laboratory exercise, the students will be able to: (1) Define an ice core and a sedimentary rock core. (Knowledge) (2) Identify climate indicators in each type of core by using digital core images. These include layers of particulate material (such as volcanic tephra) in ice cores and layers of larger grains (such as ice-rafted debris) in sedimentary rock cores. (Knowledge) (3) Describe how cores are taken in extreme environments, such as Antarctica. (Comprehension) (4) Use actual data from proxies in the ice and sedimentary records to graph changes through time in the cores. (Application) (5) Recognize variances in data sets that might illustrate periods of climate change. (Analysis) (6) Integrate data results from several proxies in order to construct a climate record for both ice cores and sedimentary rock cores. (Synthesis) (7) Interpret both the ice core and sedimentary rock core records to ascertain the effectiveness of both of these tools in archiving climate records. (Evaluation)

Women's health care: the experiences and behaviors of rural and urban lesbians in the USA.

PubMed

Barefoot, K Nikki; Warren, Jacob C; Smalley, K Bryant

2017-01-01

Previous research has consistently demonstrated that, in comparison to their cisgender heterosexual counterparts, lesbians face a multitude of women's healthcare-related disparities. However, very little research has been conducted that takes an intersectionality approach to examining the potential influences of rural-urban location on the health-related needs and experiences of lesbians. The purpose of this study was to quantitatively compare rural and urban lesbians' access to women's health care, experiences with women's healthcare providers (WHCPs), and preventive behavior using a large, diverse sample of lesbians from across the USA. A total of 895 (31.1% rural and 68.9% urban) lesbian-identified cisgender women (ie not transgender) from the USA participated in the current online study. As part of a larger parent study, participants were recruited from across the USA through email communication to lesbian, gay, bisexual, and transgender (LGBT)-focused organizations and online advertisements. Participants were asked to complete a series of questions related to their women's healthcare-related experiences and behaviors (ie access to care, experiences with WHCPs, and preventive behavior). A series of χ2 analyses were utilized in order to examine rural-urban differences across dependent variables. An examination of sexual risks revealed that relatively more rural lesbians reported at least one previous male sexual partner in comparison to the urban sample of lesbians (78.1% vs 69.1%, χ2(1, N=890)=7.56, p=0.006). A similarly low percentage of rural (42.4%) and urban (42.9%) lesbians reported that they have a WHCP that they see on a regular basis for preventive care. In terms of experiences with WHCP providers, relatively fewer rural lesbians indicated that their current WHCP had discussed/recommended the human papillomavirus (HPV) vaccination in comparison to urban lesbians (27.5% vs. 37.2%; χ2 (1, N=796)=7.24, p=0.007). No other rural-urban differences in experiences with WHCPs emerged - few rural and urban lesbians had been asked about their sexual orientation by their WHCP (38.8% and 45.0%, respectively), been provided with appropriate safe-sex education by their WHCP (21.4% and 25.3%), had their last HIV/sexually transmitted infection screening instigated by their WHCP (if applicable; 15.7% and 19.5%), and reported that their WHCP seems knowledgeable about lesbian health concerns (56.5% vs 54.6%). In terms of preventive behavior, significantly fewer rural lesbians aged 40 years or more had received a mammogram in the past 3 years (63.2% vs 83.2%; χ2(1, N=163)=8.36, p=0.004) when compared to their urban counterparts. No other significant rural-urban differences in preventive behaviors emerged. A similarly low percentage of rural and urban lesbians indicated that they have received the HPV vaccination (22.8% and 29.0%, respectively) and/or have had a HIV/STI screening (43.0% and 47.8%), Pap test (62.0% and 64.5%) or breast exam (59.2% and 62.8%), in the past 3 years. The current findings highlight that rural lesbians in the USA, in comparison to urban lesbians, may experience elevated health risks related to being more likely to have at least one previous male sexual partner, less likely to be recommended the HPV vaccination by a WHCP, and, for those 40 or older, less likely to receive routine mammogram screenings. Furthermore, rural lesbians appear to engage in similarly low rates of HPV vaccination and regular HIV/STI screenings, Pap tests, and clinical breast exams as their urban counterparts. Given the increased cervical and breast cancer risks associated with rural living, the current findings underscore the dire need for health promotion efforts aimed at increasing rural lesbians' engagement in routine pelvic and breast exams.

International Arctic Systems for Observing the Atmosphere (IASOA): 2007 Observatory Upgrades in Canada, Greenland, Russia and the United States

NASA Astrophysics Data System (ADS)

Darby, L. S.; Uttal, T.; Burkhart, J.; Drummond, J.

2007-12-01

International Arctic Systems for Observing the Atmosphere (IASOA) is a dynamic organization developed to enhance Arctic atmospheric research by fostering collaborations among researchers during the International Polar Year (IPY) and beyond. The member stations are Abisko, Sweden; Alert and Eureka, Canada; Barrow, USA; Cherskii and Tiksi Russia; Ny-Ålesund, Norway; Pallas and Sodankylä, Finland; and Summit, Greenland. All of these observatories operate year-round, with at least minimal staffing in the winter months, are intensive and permanent. Presently, measurement and building upgrades are occurring at the Tiksi, Eureka, Summit and Barrow observatories. A new weather station building has been completed in Tiksi and is currently available for installation of instruments. A second Clean Air Facility (CAF) that will be suitable for aerosol, chemistry, pollutant, greenhouse gases, fluxes and radiation measurements is expected to be completed in the spring of 2008. Real- time continuous measurement instruments for the measurement of ozone and black carbon, and flasks for carbon cycle gas measurements for the new Tiksi station are awaiting shipping from Boulder, CO. At the Eureka site many instruments including a flux tower, several CIMELs for the Aeronet Network, and a Baseline Surface Radiation Network (BSRN) station were installed in the summer of 2007. With IPY funding the level of technical support at the site has been increased to provide more reliable data collection and transmission. The Summit, Greenland observatory has recently released a strategic plan highlighting climate sensitive year- round observations, innovative research platforms and operational plans to increase renewable energy to maintain the pristine platform. Summit also has a new multi-channel GC/MS for continuous measurement of trace halocarbon and CFC gas concentrations. All NOAA instruments have been moved from the Science trench to a new atmospheric watch observatory building. NOAA is now manning the site for the 9-month winter season of the year. The Barrow observatory has two new systems for aerosol size and chemistry composition, as well as new POPs measurements. The meteorology measurement and data system has been completely upgraded. Current IASOA activities include the development of a web site (www.iasoa.org) that will serve as the "go-to" site for atmospheric Arctic researchers to obtain information about the member observatories. Information posted for each station includes a general overview of the observatory, a listing of available measurements and principle investigators, links to data bases, and station contacts. These pages will help Arctic researchers find the data they need to complete their research. The development of these observatory web pages, plus an "observatories- at-a-glance" page, has allowed us to identify gaps in atmospheric measurements in the Arctic.

Age-related changes in the auditory brainstem response.

PubMed

Konrad-Martin, Dawn; Dille, Marilyn F; McMillan, Garnett; Griest, Susan; McDermott, Daniel; Fausti, Stephen A; Austin, Donald F

2012-01-01

This cross-sectional study had two goals: (1) Identify and quantify the effects of aging on the auditory brainstem response (ABR); (2) Describe how click rate and hearing impairment modify effects of aging. RESEARCH DESIGN AND ANALYSIS: ABR measures were obtained from 131 predominately male Veteran participants aged 26 to 71 yr. Metrics analyzed include amplitude and latency for waves I, III, and V, and the I-V interpeak latency interval (IPI) at three repetition rates (11, 51, and 71 clicks/sec) using both polarities. In order to avoid confounding from missing data due to hearing impairment, participants had hearing thresholds <40 dB HL at 2 kHz and 70 dB HL at 4 kHz in at least one ear. Additionally, the median 2, 3, and 4 kHz pure tone threshold average (PTA2,3,4) for the sample, ∼17 dB HL, was used to delineate subgroups of better and worse hearing ears, and only the better hearing sample was modeled statistically. We modeled ABR responses using age, repetition rate, and PTA2,3,4 as covariates. Random effects were used to model correlation between the two ears of a subject and across repetition rates. Inferences regarding effects of aging on ABR measures at each rate were derived from the fitted model. Results were compared to data from subjects with poorer hearing. Aging substantially diminished amplitudes of all of the principal ABR peaks, largely independent of any threshold differences within the group. For waves I and III, age-related amplitude decrements were greatest at a low (11/sec) click rate. At the 11/sec rate, the model-based mean wave III amplitude was significantly smaller in older compared with younger subjects even after adjusting for wave I amplitude. Aging also increased ABR peak latencies, with significant shifts limited to early waves. The I-V IPI did not change with age. For both younger and older subjects, increasing click presentation rate significantly decreased amplitudes of early peaks and prolonged latencies of later peaks, resulting in increased IPIs. Advanced age did not enhance effects of rate. Instead, the rate effect on wave I and III amplitudes was attenuated for the older subjects due to reduced peak amplitudes at lower click rates. Compared with model predictions from the sample of better hearing subjects, mean ABR amplitudes were diminished in the group with poorer hearing, and wave V latencies were prolonged. In a sample of veterans, aging substantially reduced amplitudes of all principal ABR peaks, with significant latency shifts limited to waves I and III. Aging did not influence the I-V IPI even at high click rates, suggesting that the observed absolute latency changes associated with aging can be attributed to changes in auditory nerve input. In contrast, ABR amplitude changes with age are not adequately explained by changes in wave I. Results suggest that aging reduces the numbers and/or synchrony of contributing auditory nerve units. Results also support the concept that aging reduces the numbers, though perhaps not the synchrony, of central ABR generators. American Academy of Audiology.

PolarTREC-Teachers and Researchers Exploring and Collaborating: Bringing Polar Research to the Classroom

NASA Astrophysics Data System (ADS)

Warnick, W. K.; Warburton, J.; Breen, K.; Wiggins, H. V.; Larson, A.; Behr, S.

2006-12-01

PolarTREC-Teachers and Researchers Exploring and Collaborating is a three-year (2007-2009) teacher professional development program that pairs K-12 teachers with researchers to improve science education through authentic polar research experience. PolarTREC builds on the strengths of the existing TREC program in the Arctic, an NSF supported program managed by the Arctic Research Consortium of the US (ARCUS), to embrace a wider range of research activities in the Arctic and Antarctic. PolarTREC uses a Teacher Research Experience (TRE) model to foster the integration of research and education to produce a legacy of long-term teacher-researcher collaborations, improved teacher content knowledge through experiences in scientific inquiry, and broad public interest and engagement in polar science. PolarTREC will enable thirty-six teachers to spend two to six weeks in the Arctic or Antarctic, working closely with researchers investigating a wide range of topics such as sea-ice dynamics, terrestrial ecology, marine biology, atmospheric chemistry, and long-term climate change. With the help of their host researcher and the research team, teachers will develop the experience and tools necessary to teach science through scientific inquiry and investigation based on real-world experiences. While in the field, teachers and researchers will communicate extensively with their colleagues, communities, and hundreds of students of all ages across the globe, using a variety of tools including satellite phones, online journals, podcasts and interactive "Live from IPY" calls and web-based seminars. The online outreach elements of the project convey these experiences to a broad audience far beyond the classrooms of the PolarTREC teachers. In addition to field research experiences, PolarTREC will support teacher professional development and a sustained community of teachers, scientists, and the public through workshops, Internet seminars, an e-mail listserve, and ongoing teacher/researcher networks. For further information on PolarTREC, contact Wendy Warnick, ARCUS Executive Director at warnick@arcus.org or 907-474-1600. The PolarTREC website will be accessible in 2007 through the ARCUS web site at www.arcus.org.

Postcards from the Field: Using the Web to Bring Near-Real Time Field Work to the Public

NASA Astrophysics Data System (ADS)

Genyuk, J.; Johnson, R. M.; Gardiner, L.; Russell, R.; Bergman, J.; Lagrave, M.; Hatheway, B.; Foster, S.; Araujo-Pradere, E. A.

2007-12-01

Field work is one of the aspects of a career in the geosciences that can make it so attractive to students and the public. The chance to go to exciting places, and to see amazing things, while making new discoveries is almost too good to be true. The "Postcards from the Field" capability, developed and implemented in the Windows to the Universe website project in 2006, is now providing a new ability to bring this excitement to a large and global audience online. Windows to the Universe is an extremely popular interdisciplinary Earth and space science educational website, with over 20 million visitors per year, including a large following of students and educators. The website is composed of over 7000 interlinked web pages spanning the geosciences, at three levels of sophistication, in English and Spanish. Our Postcards from the Field capability, which was originally developed in support of a major field campaign in Mexico City in 2006 (the Megacity Initiative: Local and Global Research Observations campaign - MILAGRO), has now been generalized to support submissions from researchers engaged in multiple field campaigns. To date, in addition to postcards submitted during the MILAGRO campaign, we have hosted postcards from researchers and educators studying the life cycle of Adelie penguins in the Antarctic, the East Pacific Rise as a component of the RIDGE2000 program, and storm formation in Europe as a component of the Convective and Orographically- induced Precipitation Study (COPS). We are now expanding our postcard lines to include submissions from researchers engaged in the IPY and educators engaged with the ANDRILL (ANtarctic Geologic DRILLing) Research Immersion for Science Educators program. This presentation will present this new capability, its ease of use, and our vision for how it can be used to bring the excitement of field research to the public, students, and educators online.

Pakistan: Ascending a Path through Regional Turmoil

DTIC Science & Technology

2013-03-01

Correspondingly, the US perceives that it is Pakistan’s unwarranted and paranoid fear of India (and mistrust of the reliability of the US) that is causing...For instance, Pakistan has welcomed the Iranian offer to overcome its energy crisis with the building of the Iran-Pakistan-India (IPI) gas pipeline...mitigate its effects. It may have to look both inwards and outwards to overcome this emerging crisis. It will have to carefully develop a viable

Induced abortion - impact on a subsequent pregnancy in first-time mothers: a registry-based study.

PubMed

Holmlund, Susanna; Kauko, Tommi; Matomäki, Jaakko; Tuominen, Miia; Mäkinen, Juha; Rautava, Päivi

2016-10-24

To date, several studies concerning the effects of induced abortion (IA) on women's later psychosocial well-being and future delivery complications have been published. However, the lack of reports on woman's physical well-being during their first full-term pregnancy occurring after IA is what inspired the current study. Here, we evaluate the physical well-being and use of maternity services of first-time mothers with a history of IA. Finnish National Birth Registry data from 2008 to 2010 were linked with the Induced Abortion Registry data from 1983 to 2007. After excluding first-time mothers with a history of miscarriage, ectopic pregnancy or delivery, 57,406 mothers were eligible for the study, with 5,167 (9.0 %) having experienced prior IA. Data from the pregnancy follow-up visits were evaluated and compared between IA mothers and primiparous mothers. Women with IA had higher rates of smoking after the first trimester and were more likely to be overweight (body mass index >25 kg/m 2 ) than the control group mothers. A higher use of maternity health clinic (MHC) services, thrombosis prophylaxis and participation in a second trimester ultrasound and amniotic fluid sample testing were evident in IA mothers, whereas the likelihood of assisted fertilisation procedure(s) was elevated in the control group. A shorter interpregnancy interval (IPI) seemed to contribute to a late first MHC visit and first trimester serum screening test participation, a higher incidence of placenta samples and an increased presence of preeclampsia and maternal care for poor foetal growth. IA is associated with being overweight before the subsequent pregnancy and with smoking after the first trimester. More frequent pregnancy follow-up visits in the IA group may be due to greater participation in the placenta sample testing and use of thrombosis prophylaxis. No association between IA and preeclampsia, hypertension, gestational diabetes or preterm premature rupture of membranes was evident in the pregnancy parameters. According to our findings, experiencing IA decreased the need for fertilisation procedures before the next pregnancy when compared to primiparous mothers. Among the IA mothers, the short IPI seemed to contribute to the higher risk for preeclampsia and maternal care for poor foetal growth. However, more research is needed around the IPI before establishing its effect on later pregnancy.

Group Waterpipe Tobacco Smoking Increases Smoke Toxicant Concentration

PubMed Central

Ramôa, Carolina P.; Shihadeh, Alan; Salman, Rola

2016-01-01

Abstract Introduction: Waterpipe tobacco smoking is a global health concern. Laboratory research has focused on individual waterpipe users while group use is common. This study examined user toxicant exposure and smoke toxicant yield associated with individual and group waterpipe smoking. Methods: Twenty-two pairs of waterpipe smokers used a waterpipe individually and as a dyad. Before and after smoking, blood was sampled and expired carbon monoxide (CO) measured; puff topography was recorded throughout. One participant from each pair was selected randomly and their plasma nicotine and expired air CO concentrations were compared when smoking alone to when smoking as part of a dyad. Recorded puff topography was used to machine-produce smoke that was analyzed for toxicant content. Results: There was no difference in mean plasma nicotine concentration when an individual smoked as part of a dyad (mean = 14.9ng/ml; standard error of the mean [ SEM ] = 3.0) compared to when smoking alone (mean = 10.0ng/ml; SEM = 1.5). An individual smoking as part of as a dyad had, on average, lower CO (mean = 15.8 ppm; SEM = 2.0) compared to when smoking alone (mean= 21.3 ppm; SEM = 2.7). When two participants smoked as a dyad they took, on average, more puffs (mean = 109.8; SEM = 7.6) than a singleton smoker (mean = 77.7; SEM = 8.1) and a shorter interpuff interval (IPI; dyad mean = 23.8 seconds; SEM = 1.9; singleton mean = 40.8 seconds; SEM = 4.8). Higher concentrations of several toxicants were observed in dyad-produced smoke. Discussion: Dyad smoking may increase smoke toxicant content, likely due to the dyad’s shorter IPIs and greater puff number. More work is needed to understand if group waterpipe smoking alters the health risks of waterpipe tobacco smoking. Implications: This study is the first to measure toxicants in smoke generated from a waterpipe when used by a dyad. Relative to smoke generated by a singleton, dyad smoke had higher concentration of some toxicants. These differences may be attributed to differences in puffing behavior, specifically the shorter IPI and greater puff number observed in the dyad condition. Relative to singleton smokers, dyad smokers were exposed to less CO, but nicotine exposure did not differ. More work is needed to assess the health effects of inhalation of more toxicant-laden smoke during group waterpipe use. PMID:26659913

Irradiation performance of AGR-1 high temperature reactor fuel

DOE PAGES

Demkowicz, Paul A.; Hunn, John D.; Ploger, Scott A.; ...

2015-10-23

The AGR-1 experiment contained 72 low-enriched uranium oxide/uranium carbide TRISO coated particle fuel compacts in six capsules irradiated to burnups of 11.2 to 19.6% FIMA, with zero TRISO coating failures detected during the irradiation. The irradiation performance of the fuel including the extent of fission product release and the evolution of kernel and coating microstructures was evaluated based on detailed examination of the irradiation capsules, the fuel compacts, and individual particles. Fractional release of 110mAg from the fuel compacts was often significant, with capsule-average values ranging from 0.01 to 0.38. Analysis of silver release from individual compacts indicated that itmore » was primarily dependent on fuel temperature history. Europium and strontium were released in small amounts through intact coatings, but were found to be significantly retained in the outer pyrocarbon and compact matrix. The capsule-average fractional release from the compacts was 1 × 10 –4 to 5 × 10 –4 for 154Eu and 8 × 10 –7 to 3 × 10 –5 for 90Sr. The average 134Cs fractional release from compacts was <3 × 10 –6 when all particles maintained intact SiC. An estimated four particles out of 2.98 × 10 5 in the experiment experienced partial cesium release due to SiC failure during the irradiation, driving 134Cs fractional release in two capsules to approximately 10 –5. Identification and characterization of these particles has provided unprecedented insight into the nature and causes of SiC coating failure in high-quality TRISO fuel. In general, changes in coating morphology were found to be dominated by the behavior of the buffer and inner pyrolytic carbon (IPyC), and infrequently observed SiC layer damage was usually related to cracks in the IPyC. Palladium attack of the SiC layer was relatively minor, except for the particles that released cesium during irradiation, where SiC corrosion was found adjacent to IPyC cracks. In conclusion, palladium, silver, and uranium were found in the SiC layer of irradiated particles, and characterization of these elements within the SiC microstructure is the subject of ongoing focused study.« less

ESSEA K-4 Online Course: Polar Connections

NASA Astrophysics Data System (ADS)

Blaney, L.; Myers, R. J.; Schwerin, T.

2007-12-01

The Earth System Science Education Alliance (ESSEA) is a National Science Foundation-supported program implemented by the Institute for Global Environmental Strategies (IGES) to improve the quality of geoscience instruction for pre-service, middle, and high school teachers. ESSEA increases teachers' access to quality materials, standards-based instructional methods and content knowledge. Started in 2000 and based on a trio of online courses (for elementary, middle, and high school teachers), the courses have been used by 40 faculty at 20 institutions educating over 1,700 teachers in Earth system science. Program evaluation of original course participants indicated that the courses had significant impact on teachers Earth system content knowledge and beliefs about teaching and learning. Seventeen of the original participating institutions have continued to use the courses and many have developed new programs that incorporate the courses in Earth science education opportunities for teachers. Today the ESSEA program lists nearly 40 colleges and universities as participants. The original K-4 course and modules have been revised to include topics and resources focusing on the International Polar Year. The new K-4 Land, Living Things, Water and Air modules contain inquiry-based investigations exploring our polar regions. Each module lists a set of essential questions that guide teachers and their students as they build content knowledge. The course structure requires teachers to work individually and in teams to build content knowledge and pedagogical understanding of how their students learn. This group investigation approach and a "Teacher as Researcher" theme promote reflection and collaboration to develop criteria for effective concept building. By exploring the characteristics of polar landscapes, atmosphere, and polar life, teachers and their students will develop new understandings about the interactions and dependencies of the Earth spheres and our polar regions. Changes in climate, air, water, and land quality and animal and plant populations make the news everyday. The K-4 course will help teachers inform rather than frighten their students as they learn more about the characteristics and importance of our polar regions. One goal of IPY 2007-2008 is to increase the awareness, understanding and interest of school-age children in polar conditions and research. The inclusion of polar topics in the K-4 course contributes to the achievement of that goal.

Psychiatric morbidity in prisoners

PubMed Central

Kumar, Vinod; Daria, Usha

2013-01-01

Background: Prisoners are having high percentage of psychiatric disorders. Majority of studies done so far on prisoners are from Western countries and very limited studies from India. Aim: Study socio-demographic profile of prisoners of a central jail and to find out current prevalence of psychiatric disorders in them. Materials and Methods: 118 prisoners were selected by random sampling and interviewed to obtain socio-demographic data and assessed on Indian Psychiatric Interview Schedule (IPIS) with additional required questions to diagnose psychiatric disorders in prisoners. Results: Mean age of prisoners was 33.7 years with 97.5% males, 57.6% from rural areas and 65.3% were married. Average education in studied years was 6.6 years and 50.8% were unskilled workers. 47.4% were murderers while 20.3% of drugs related crimes. 47.5% were convicted and history of criminal behavior in family was in 32.2% prisoners. Current prevalence of psychiatric disorders was 33%. Psychotic, depressive, and anxiety disorders were seen in 6.7%, 16.1%, and 8.5% prisoners respectively. 58.8% had history of drug abuse/dependence prior to imprisonment. Conclusion: One prison of Hadoti region of Rajasthan is full of people with mental-health problems who collectively generate significant levels of unmet psychiatric treatment need. Prisons are detrimental to mental-health. Beginning of reforms is the immediate need. PMID:24459308

Cramer-Rao Bound, MUSIC, and Maximum Likelihood. Effects of Temporal Phase Difference

DTIC Science & Technology

1990-11-01

Technical Report 1373 November 1990 Cramer-Rao Bound, MUSIC , And Maximum Likelihood Effects of Temporal Phase o Difference C. V. TranI OTIC Approved... MUSIC , and Maximum Likelihood (ML) asymptotic variances corresponding to the two-source direction-of-arrival estimation where sources were modeled as...1pI = 1.00, SNR = 20 dB ..................................... 27 2. MUSIC for two equipowered signals impinging on a 5-element ULA (a) IpI = 0.50, SNR

Preparation of Simulated LBL Defects for Round Robin Experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gerczak, Tyler J.; Baldwin, Charles A.; Hunn, John D.

2016-01-01

A critical characteristic of the TRISO fuel design is its ability to retain fission products. During reactor operation, the TRISO layers act as barriers to release of fission products not stabilized in the kernel. Each component of the TRISO particle and compact construction plays a unique role in retaining select fission products, and layer performance is often interrelated. The IPyC, SiC, and OPyC layers are barriers to the release of fission product gases such as Kr and Xe. The SiC layer provides the primary barrier to release of metallic fission products not retained in the kernel, as transport across themore » SiC layer is rate limiting due to the greater permeability of the IPyC and OPyC layers to many metallic fission products. These attributes allow intact TRISO coatings to successfully retain most fission products released from the kernel, with the majority of released fission products during operation being due to defective, damaged, or failed coatings. This dominant release of fission products from compromised particles contributes to the overall source term in reactor; causing safety and maintenance concerns and limiting the lifetime of the fuel. Under these considerations, an understanding of the nature and frequency of compromised particles is an important part of predicting the expected fission product release and ensuring safe and efficient operation.« less

A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.

PubMed

Germe, Thomas; Vörös, Judit; Jeannot, Frederic; Taillier, Thomas; Stavenger, Robert A; Bacqué, Eric; Maxwell, Anthony; Bax, Benjamin D

2018-05-04

Imidazopyrazinones (IPYs) are a new class of compounds that target bacterial topoisomerases as a basis for their antibacterial activity. We have characterized the mechanism of these compounds through structural/mechanistic studies showing they bind and stabilize a cleavage complex between DNA gyrase and DNA ('poisoning') in an analogous fashion to fluoroquinolones, but without the requirement for the water-metal-ion bridge. Biochemical experiments and structural studies of cleavage complexes of IPYs compared with an uncleaved gyrase-DNA complex, reveal conformational transitions coupled to DNA cleavage at the DNA gate. These involve movement at the GyrA interface and tilting of the TOPRIM domains toward the scissile phosphate coupled to capture of the catalytic metal ion. Our experiments show that these structural transitions are involved generally in poisoning of gyrase by therapeutic compounds and resemble those undergone by the enzyme during its adenosine triphosphate-coupled strand-passage cycle. In addition to resistance mutations affecting residues that directly interact with the compounds, we characterized a mutant (D82N) that inhibits formation of the cleavage complex by the unpoisoned enzyme. The D82N mutant appears to act by stabilizing the binary conformation of DNA gyrase with uncleaved DNA without direct interaction with the compounds. This provides general insight into the resistance mechanisms to antibiotics targeting bacterial type II topoisomerases.

A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance

PubMed Central

Germe, Thomas; Vörös, Judit; Jeannot, Frederic; Taillier, Thomas; Stavenger, Robert A; Bacqué, Eric; Bax, Benjamin D

2018-01-01

Abstract Imidazopyrazinones (IPYs) are a new class of compounds that target bacterial topoisomerases as a basis for their antibacterial activity. We have characterized the mechanism of these compounds through structural/mechanistic studies showing they bind and stabilize a cleavage complex between DNA gyrase and DNA (‘poisoning’) in an analogous fashion to fluoroquinolones, but without the requirement for the water–metal–ion bridge. Biochemical experiments and structural studies of cleavage complexes of IPYs compared with an uncleaved gyrase–DNA complex, reveal conformational transitions coupled to DNA cleavage at the DNA gate. These involve movement at the GyrA interface and tilting of the TOPRIM domains toward the scissile phosphate coupled to capture of the catalytic metal ion. Our experiments show that these structural transitions are involved generally in poisoning of gyrase by therapeutic compounds and resemble those undergone by the enzyme during its adenosine triphosphate-coupled strand-passage cycle. In addition to resistance mutations affecting residues that directly interact with the compounds, we characterized a mutant (D82N) that inhibits formation of the cleavage complex by the unpoisoned enzyme. The D82N mutant appears to act by stabilizing the binary conformation of DNA gyrase with uncleaved DNA without direct interaction with the compounds. This provides general insight into the resistance mechanisms to antibiotics targeting bacterial type II topoisomerases. PMID:29538767

A method for estimating mount isolations of powertrain mounting systems

NASA Astrophysics Data System (ADS)

Qin, Wu; Shangguan, Wen-Bin; Luo, Guohai; Xie, Zhengchao

2018-07-01

A method for calculating isolation ratios of mounts at a powertrain mounting systems (PMS) is proposed assuming a powertrain as a rigid body and using the identified powertrain excitation forces and the measured IPI (input point inertance) of mounting points at the body side. With measured accelerations of mounts at powertrain and body sides of one Vehicle (Vehicle A), the excitation forces of a powertrain are identified using conversational method firstly. Another Vehicle (Vehicle B) has the same powertrain as that of Vehicle A, but with different body and mount configuration. The accelerations of mounts at powertrain side of a PMS on Vehicle B are calculated using the powertrain excitation forces identified from Vehicle A. The identified forces of the powertrain are validated by comparing the calculated and the measured accelerations of mounts at the powertrain side of the powertrain on Vehicle B. A method for calculating acceleration of mounting point at body side for Vehicle B is presented using the identified powertrain excitation forces and the measured IPI at a connecting point between car body and mount. Using the calculated accelerations of mounts at powertrain side and body side at different directions, the isolation ratios of a mount are then estimated. The isolation ratios are validated using the experiment, which verified the proposed methods for estimating isolation ratios of mounts. The developed method is beneficial for optimizing mount stiffness to meet mount isolation requirements before prototype.

The Glasgow Prognostic Score as a significant predictor of diffuse large B cell lymphoma treated with R-CHOP in China.

PubMed

Li, Xiaoyang; Zhang, Yunxiang; Zhao, Weili; Liu, Zhao; Shen, Yang; Li, Junmin; Shen, Zhixiang

2015-01-01

The Glasgow Prognostic Score (GPS) incorporates C-reactive protein and albumin as clinically useful markers of tumor behavior and shows significant prognostic value in several types of solid tumors. The accuracy of the GPS in predicting outcomes in diffuse large B cell lymphoma (DLBCL) remains unknown. We performed this study to evaluate the prognostic significance of the GPS in DLBCL in China. We retrospectively analyzed 160 patients with newly diagnosed DLBCL at the Shanghai Ruijin Hospital (China). The prognostic value of the GPS was evaluated and compared with that of the International Prognostic Index (IPI) and immunohistochemical subtyping. The GPS was defined as follows: GPS-0, C-reactive protein (CRP) ≤10 mg/L and albumin ≥35 g/L; GPS-1, CRP >10 mg/L or albumin <35 g/L; and GPS-2, CRP >10 mg/L and albumin <35 g/L. Patients with lower GPS tended to have better outcomes including progression-free survival (PFS, P < 0.001) and overall survival (OS, P < 0.001). Multivariate analysis demonstrated that high GPS and high IPI score were independent adverse predictors of OS. Similar to several other tumors, GPS is a reliable predictor of survival outcomes in DLBCL patients treated with R-CHOP therapy. Inflammatory responses are implicated in the progression and survival of patients with DLBCL.

Acceptance Test Data for BWXT Coated Particle Batch 93164A Defective IPyC Fraction and Pyrocarbon Anisotropy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Helmreich, Grant W.; Hunn, John D.; Skitt, Darren J.

2017-02-01

Coated particle fuel batch J52O-16-93164 was produced by Babcock and Wilcox Technologies (BWXT) for possible selection as fuel for the Advanced Gas Reactor Fuel Development and Qualification (AGR) Program’s AGR-5/6/7 irradiation test in the Idaho National Laboratory (INL) Advanced Test Reactor (ATR), or may be used as demonstration production-scale coated particle fuel for other experiments. The tristructural-isotropic (TRISO) coatings were deposited in a 150-mm-diameter production-scale fluidizedbed chemical vapor deposition (CVD) furnace onto 425-μm-nominal-diameter spherical kernels from BWXT lot J52L-16-69316. Each kernel contained a mixture of 15.5%-enriched uranium carbide and uranium oxide (UCO) and was coated with four consecutive CVD layers:more » a ~50% dense carbon buffer layer with 100-μm-nominal thickness, a dense inner pyrolytic carbon (IPyC) layer with 40-μm-nominal thickness, a silicon carbide (SiC) layer with 35-μm-nominal thickness, and a dense outer pyrolytic carbon (OPyC) layer with 40-μm-nominal thickness. The TRISO-coated particle batch was sieved to upgrade the particles by removing over-sized and under-sized material, and the upgraded batch was designated by appending the letter A to the end of the batch number (i.e., 93164A).« less

Prognostic roles of absolute monocyte and absolute lymphocyte counts in patients with advanced-stage follicular lymphoma in the rituximab era: an analysis from the FOLL05 trial of the Fondazione Italiana Linfomi.

PubMed

Marcheselli, Luigi; Bari, Alessia; Anastasia, Antonella; Botto, Barbara; Puccini, Benedetta; Dondi, Alessandra; Carella, Angelo M; Alvarez, Isabel; Chiarenza, Annalisa; Arcari, Annalisa; Salvi, Flavia; Federico, Massimo

2015-05-01

Recently, in an attempt to improve the discrimination power of the international prognostic index (IPI), patients with diffuse large B-cell lymphoma were evaluated to determine the prognostic roles of peripheral blood absolute monocyte count (AMC) and absolute lymphocyte count (ALC). Here, we analysed data of 428 patients with follicular lymphoma (FL) enrolled in a prospective, randomized trial (FOLL05 study) conducted by Fondazione Italiana Linfomi, to assess the impact of AMC and ALC on progression-free survival (PFS). All patients had been treated with one of three treatment combinations: (i) rituximab (R) plus cyclophosphamide, vincristine and prednisone; (ii) R plus cyclophosphamide, doxorubicin, vincristine and prednisone or (iii) R plus mitoxantrone and fludarabine. We showed that only AMC was a powerful predictor of PFS, and possibly overall survival, in patients with FL treated with combination chemotherapy regimens that contained R. The AMC can be used alone as a novel, simple factor that can predict survival outcome in patients with FL, independent of the immunochemotherapy regimen. It may therefore be widely used by clinicians, due to its simplicity and broad applicability. Additionally, it can be combined with other factors that determine the IPI or FLIPI, to increase the discriminating ability of these indices. © 2015 John Wiley & Sons Ltd.

Non-negative infrared patch-image model: Robust target-background separation via partial sum minimization of singular values

NASA Astrophysics Data System (ADS)

Dai, Yimian; Wu, Yiquan; Song, Yu; Guo, Jun

2017-03-01

To further enhance the small targets and suppress the heavy clutters simultaneously, a robust non-negative infrared patch-image model via partial sum minimization of singular values is proposed. First, the intrinsic reason behind the undesirable performance of the state-of-the-art infrared patch-image (IPI) model when facing extremely complex backgrounds is analyzed. We point out that it lies in the mismatching of IPI model's implicit assumption of a large number of observations with the reality of deficient observations of strong edges. To fix this problem, instead of the nuclear norm, we adopt the partial sum of singular values to constrain the low-rank background patch-image, which could provide a more accurate background estimation and almost eliminate all the salient residuals in the decomposed target image. In addition, considering the fact that the infrared small target is always brighter than its adjacent background, we propose an additional non-negative constraint to the sparse target patch-image, which could not only wipe off more undesirable components ulteriorly but also accelerate the convergence rate. Finally, an algorithm based on inexact augmented Lagrange multiplier method is developed to solve the proposed model. A large number of experiments are conducted demonstrating that the proposed model has a significant improvement over the other nine competitive methods in terms of both clutter suppressing performance and convergence rate.

PSYCHIATRIC MORBIDITY AMONG VICTIMS OF BOMB BLAST

PubMed Central

Gautam, Shiv; Gupta, I.D.; Batra, Lalit; Sharma, Himanshiu; Khandelwal, Rakesh; Pant, Anshuman

1998-01-01

Thirty one victims of bomb blast in a bus caused by terrorist activity in Dausa district, Rajasthan on 22.5.96, were evaluated for psychological reactions 3 days & 2 weeks after the incident. All hospitalized & non hospitalised bomb blast victims were assessed within 3 days of injury by objective predictors (percent of burnt area, facial disfigurement, limb amputations, fractures etc.) and subjective predictors (emotional distress and perceived social support). Detailed history, physical and mental state examination of all patients was carried out and for those having scores more then 17 on GHQ-60 (Hindi version), IPIS was administered. Diagnosis was made by 3 senior consultant psychiatrists of Psychiatric Centre, Jaipur, on the basis oflCD-10. At day 3 of 31 patients studied 11 (35.45%) had psychiatric morbidity. Out of which 6 (19.35%) had acute stress reaction, 3 (9.68%) had depression and 2 (6.45%) dissociative amnesia. Most commonly reported symptoms on IPIS were depersonalisation, derealisation, sleep disturbances specially generalised sleep loss, loss of appetite, nightmares, situational anxiety, depression, mental irritability, dulness of feelings, self blame, guilt, loss of interest, suicidal ideas, and worry about money, spouse, work and children. Most common physical injury was burns, followed by hearing disturbances, wounds received due to glass <& metal pieces and non specific pains and aches. Findings of follow up have been discussed and battery of tests for evaluation of victims of acute trauma has been suggested. PMID:21494441

[Change of Plasma Interleukin-17 Level in Patients with Extranodal NK/T-Cell Lymphoma and Its Clinical Significance].

PubMed

Shang, Chun-Xiang; Ma, Ji-Cheng; Nan, Zheng; Li, Ye; He, Wen-Cai; Pan, Xian-Ying

2017-06-01

To investigate the clinical significance of interleukin-17 (IL-17) level in patients with extranodal NK/T-cell lymphoma(ENKTL). Eighty patients with nasal ENKTL who received radiotherapy, chemotherapy or radiotherapy combined with chemotherapy from January 2011 to January 2012 were enrolled in the study. Eighty healthy volunteers were selected as the controls (control group). About 5 ml of peripheral blood was collected from all patients and controls. IL-17 level was determined by ELISA. The age, sex, ECOG score, B symptoms, LDH level, lymph node involvment, Ann Arbor stage, IPI, KPI, peripheral blood lymphocyte and lymph node metastasis, number of lymphocytes and monocytes in peripheral blood were recorded. All patients were followed up for 3 year progression-free survival (PFS) and overall survival (OS). The average IL-17 level in patients with ENKTL was 6.48 pg/ml and the average concentration of IL-17 in control group was 0.56 pg/ml (P<0.01). The level of IL-17 in patients with B-symptoms and lymph node involvement was significantly higher than that in the control group. The differences in IL-17 level were not statistically significant among patients with different age, sex, ECOG, LDH, Ann Arbor stage, IPI, KPI, lymphocyte count and monocyte cell count. The sensitivity and specificity of IL-17 were 74.5% and 73.7% respectively, and the optimal threshold was 3.49 pg/ml and AUC was 0.799 (95% CI: 0.688-0.909) (P<0.01). The PFS and OS were longer in the patients with IL-17≤3.49 pg/ml and longer in the patients without lymph node involvement and Ann Arbor I. Multivariate analysis showed that independent predictors of PFS and OS in patients with ENKTL were plasma IL-17 levels and age (P<0.05). ENKTL patients with different clinical characteristics have different levels of IL-17, the different level of IL-17 has different effects on prognosis of patients with ENKTL.

Changes in the influence of lymphoma- and HIV-specific factors on outcomes in AIDS-related non-Hodgkin lymphoma

PubMed Central

Barta, S. K.; Samuel, M. S.; Xue, X.; Wang, D.; Lee, J. Y.; Mounier, N.; Ribera, J.-M.; Spina, M.; Tirelli, U.; Weiss, R.; Galicier, L.; Boue, F.; Little, R. F.; Dunleavy, K.; Wilson, W. H.; Wyen, C.; Remick, S. C.; Kaplan, L. D.; Ratner, L.; Noy, A.; Sparano, J. A.

2015-01-01

Background We undertook the present analysis to examine the shifting influence of prognostic factors in HIV-positive patients diagnosed with aggressive non-Hodgkin lymphoma (NHL) over the last two decades. Patients and methods We carried out a pooled analysis from an existing database of patients with AIDS-related lymphoma. Individual patient data had been obtained prior from prospective phase II or III clinical trials carried out between 1990 until 2010 in North America and Europe that studied chemo(immuno)therapy in HIV-positive patients diagnosed with AIDS-related lymphomas. Studies had been identified by a systematic review. We analyzed patient-level data for 1546 patients with AIDS-related lymphomas using logistic regression and Cox proportional hazard models to identify the association of patient-, lymphoma-, and HIV-specific variables with the outcomes complete response (CR), progression-free survival, and overall survival (OS) in different eras: pre-cART (1989–1995), early cART (1996–2000), recent cART (2001–2004), and contemporary cART era (2005–2010). Results Outcomes for patients with AIDS-related diffuse large B-cell lymphoma and Burkitt lymphoma improved significantly over time, irrespective of baseline CD4 count or age-adjusted International Prognostic Index (IPI) risk category. Two-year OS was best in the contemporary era: 67% and 75% compared with 24% and 37% in the pre-cART era (P < 0.001). While the age-adjusted IPI was a significant predictor of outcome in all time periods, the influence of other factors waxed and waned. Individual HIV-related factors such as low CD4 counts (<50/mm3) and prior history of AIDS were no longer associated with poor outcomes in the contemporary era. Conclusions Our results demonstrate a significant improvement of CR rate and survival for all patients with AIDS-related lymphomas. Effective HIV-directed therapies reduce the impact of HIV-related prognostic factors on outcomes and allow curative antilymphoma therapy for the majority of patients with aggressive NHL. PMID:25632071

Unregulated pollutant emissions from on-road vehicles in China, 1999-2014.

PubMed

Lang, Jianlei; Zhou, Ying; Cheng, Shuiyuan; Zhang, Yanyun; Dong, Meng; Li, Shengyue; Wang, Gang; Zhang, Yonglin

2016-12-15

Multi-year (1999-2014) vehicular unregulated pollutants emissions in China, including SO 2 , CH 4 , N 2 O, NH 3 , Indeno(1,2,3-cd)pyrene (IPY), Benzo(k)fluoranthene (BkF), Benzo(b)fluoranthene (BbF), Benzo(a)pyrene (BaP), dioxins and furans, were estimated based on emission factors calculated by COPERT. The inter-annual trends, correlation with GDP and population, spatial distribution characteristics, contributions from various vehicle types for the ten pollutants emissions were analyzed. Results showed that the emissions of the above ten pollutants changed from approximately 576.9Gg, 130.0Gg, 8.1Gg, 2.1Gg, 1.0Mg, 1.1Mg, 1.4Mg, 0.5Mg, 7.4g and 15.6g in 1999 to 193.8Gg, 171.1Gg, 79.1Gg, 117.8Gg, 3.5Mg, 6.7Mg, 6.8Mg, 2.9Mg, 37.6g and 79.1g in 2014, respectively. Implementation of stringent sulfur content limit during the past decade reduced approximately 94.4% of the SO 2 emission in 2014. CH 4 and N 2 O increased from 1999 to 2011, but began to decrease since 2012; NH 3 emission had the highest annual average change rate (35.5%) from 1999 to 2014; PAHs, dioxins and furans increased continuously during the past decade. The vehicular emissions were higher in Guangdong, Shandong, Henan, Jiangsu, Zhejiang and Hebei. Good linear correlation between vehicular emissions and GDP was found (except SO 2 ); in the provinces/municipalities with higher population density, the emission density was also larger, indicating more significant vehicular emissions' potential damage on human health. HDT and PC, PC and MC, PC and BUS were the major contributors to SO 2 , CH 4 , N 2 O emissions, respectively. In 2014, PC was the dominant contributor to NH 3 emission; PC, BUS and HDT had higher fraction in the total IPY and BaP emissions; HDT was the major contributor to BkF and BbF emissions. In addition, the uncertainties of estimated emissions were also analyzed based on Monte Carlo simulation. Copyright © 2016 Elsevier B.V. All rights reserved.

Q-TWiST analysis comparing ipilimumab/dacarbazine vs placebo/dacarbazine for patients with stage III/IV melanoma

PubMed Central

Sherrill, B; Wang, J; Kotapati, S; Chin, K

2013-01-01

Background: Study CA184024 was a multinational, randomised, double-blind, phase 3 study comparing ipilimumab/dacarbazine (DTIC) vs placebo/DTIC in patients with untreated stage III/IV melanoma, which showed that ipilimumab significantly improves survival in patients with metastatic melanoma. The objective of this analysis was to compare the quality-adjusted survival experience among patients in this trial. Methods: Survival time was partitioned into health states: toxicity, time before progression without toxicity, and relapse until death or end of follow-up. Q-TWiST (quality-adjusted time without symptoms of disease or toxicity of treatment) was calculated as the utility-weighted sum of the mean health state durations. Analyses were repeated over extended follow-up periods. Results: Based on a combination of trial-based and external utility scores, the Q-TWiST difference in this trial was 0.50 months (P=0.0326) favoring ipilimumab after 1 year. The Q-TWiST difference was 1.5 months with 2 years of follow-up (P=0.0091), 2.36 months at 3 years (P=0.005) and 3.28 months at 4 years (P=0.0074). Conclusion: During the first year of study, there was little difference between groups in quality-adjusted survival. However, after 2, 3 and 4 years follow-up for patients with extended survival, the benefits of IPI+DTIC vs PLA+DTIC for advanced melanoma continue to accrue. PMID:23787916

Arctic Research Mapping Application (ARMAP): 2D Maps and 3D Globes Support Arctic Science

NASA Astrophysics Data System (ADS)

Johnson, G.; Gaylord, A. G.; Brady, J. J.; Cody, R. P.; Aguilar, J. A.; Dover, M.; Garcia-Lavigne, D.; Manley, W.; Score, R.; Tweedie, C. E.

2007-12-01

The Arctic Research Mapping Application (ARMAP) is a suite of online services to provide support of Arctic science. These services include: a text based online search utility, 2D Internet Map Server (IMS); 3D globes and Open Geospatial Consortium (OGC) Web Map Services (WMS). With ARMAP's 2D maps and 3D globes, users can navigate to areas of interest, view a variety of map layers, and explore U.S. Federally funded research projects. Projects can be queried by location, year, funding program, discipline, and keyword. Links take you to specific information and other web sites associated with a particular research project. The Arctic Research Logistics Support Service (ARLSS) database is the foundation of ARMAP including US research funded by the National Science Foundation, National Aeronautics and Space Administration, National Oceanic and Atmospheric Administration, and the United States Geological Survey. Avoiding a duplication of effort has been a primary objective of the ARMAP project which incorporates best practices (e.g. Spatial Data Infrastructure and OGC standard web services and metadata) and off the shelf technologies where appropriate. The ARMAP suite provides tools for users of various levels of technical ability to interact with the data by importing the web services directly into their own GIS applications and virtual globes; performing advanced GIS queries; simply printing maps from a set of predefined images in the map gallery; browsing the layers in an IMS; or by choosing to "fly to" sites using a 3D globe. With special emphasis on the International Polar Year (IPY), ARMAP has targeted science planners, scientists, educators, and the general public. In sum, ARMAP goes beyond a simple map display to enable analysis, synthesis, and coordination of Arctic research. ARMAP may be accessed via the gateway web site at http://www.armap.org.

From IGY to IPY, the U.S. Antarctic Oversnow and Airborne Geophysical-Glaciological Research Program from 1957 to 1964 from the View of a Young Graduate Student

NASA Astrophysics Data System (ADS)

Behrendt, J. C.

2006-12-01

When 12 countries established scientific stations in Antarctica for the 1957-58 International Geophysical Year (IGY), the Cold War was at its height, seven countries had made claims in Antarctica, and the Antarctic Treaty was a few years in the future. I was a graduate student assistant seismologist, on the unexplored Filchner- Ronne Ice Shelf as part of the only major field project of the U.S. Antarctic program. Starting in 1957, the U.S. began a series of oversnow traverses making seismic reflection ice soundings (and other geophysical measurements) and glaciological studies to determine the thickness and budget of the Antarctic Ice Sheet. The U.S.S.R. and France made similar traverses coordinated through the IGY. Although geology and topographic mapping were not part of the IGY program because of the claims issue and the possibility of mineral resources, the oversnow traverse parties did geologic work, where unknown mountains were discovered. The oversnow traverses continued through 1966 and resulted in an excellent first approximation of the snow surface elevation, ice thickness and bed topography of Antarctica, as well as the mean annual temperature of that era and snow accumulation. The vacuum tube dictated the logistics of the oversnow traverse program. Seismic equipment including heavy batteries weighed about 500 kg. Therefore a Sno-Cat tracked vehicle was needed to carry this load. Usually three such vehicles were needed for safety. Because about 3 l/km of fuel were consumed by each Sno-Cat, about 100 kg/day of fuel per vehicle was required. A resupply flight could carry only ~600 kg/flight (varying greatly as to range and type of aircraft).The Filchner Ice Shelf Traverse, 1957-58, in which I participated, encountered many crevasses. Vehicles broke through thin snow bridges and one man fell deep into a crevasse. Fortunately there were no deaths and only one serious injury resulting from crevasse accidents on the U.S. oversnow traverse program. Starting in 1958 and continuing to 1964 the oversnow traverses were complimented by an airborne geophysical program comprising widely spaced landings for seismic reflection ice sounding and 75,000 km of widely spaced aeromagnetic and snow surface elevation profiles. The airborne profiles were concentrated over the West Antarctic Ice Sheet (WAIS) and along the length of the Transantarctic Mountains, and approximately defined the vast extent of a late Cenozoic volcanic province beneath the WAIS associated with the unknown West Antarctic rift system. There were numerous hazards encountered using these U.S. Navy planes of opportunity including denting a wing on a hidden mountain and a crash on one occasion killing the geophysicist (Edward Thiel) and four others. There was an aircraft death rate of 3.8 deaths per year in the U.S. program from 1955-66. The oversnow and airborne traverses of the IGY-IGC period employed the inductive method of scientific research with only the general objectives of defining the Antarctic Ice Sheet as to surface elevation, thickness, snow accumulation and temperature. In contrast, Antarctic research today employs deductive logic with narrowly defined objectives and testing of hypotheses. This change has been necessary because of expense, and competition of proposals by many scientists. Nonetheless something has been lost by this approach, and there is still the need for "exploration" types of research is the still unknown vast continent of Antarctica.

Bibliography on Cold Regions Science and Technology. Volume 43. Part 2

DTIC Science & Technology

1989-12-01

Norem, H., ci a ). ’(1987, p.363-379. engl Influence of ship hull forms on propulsion performance in 1985-1988. Kujals, P.. (1989. p.1 118-1 129... performance of& a ship in ipi Radiative energy budget in the cloudy and hazy Arctic as.Msrkhisskiy interfluve (1988, p.3.1 1, rusl 43Z51 red rfies...2820 els and a ship model between two ice model baims (1988. M.V. Arctic manocuvriog performance is ice. Final report Oxygen isotopic cemposition and

Technology Insertion (TI)/Industrial Process Improvement (IPI) Task Order Number 1. Quick Fix Plan for WR-ALC, 7 RCC’s

DTIC Science & Technology

1989-09-25

Orders and test specifications. Some mandatory replacement of high failure items are directed by Technical Orders to extend MTBF. Precision bearing and...Experience is very high but natural attrition is reducing the numbers faster than training is furnishing younger mechanics. Surge conditions would be...model validation run output revealed that utilization of equipment is very low and manpower is high . Based on this analysis and the brainstorming

Boundary Layers Induced by Three-Dimensional Vortex Loops

DTIC Science & Technology

1993-12-01

obtained analytically (see Appendix B) and are given by =-2 Oz,(sin0 -)I- k IK(I IckI) - sKo (Y I k ) Cosa, (2.35) 1= -2 1 k Oq IIJ~ G=2 -’(cosO-y’)lkl...F- Ko (o Ipl) 279Ul I 280 p = if’, and similarly U a E(g) = 2(g 2 + a2)3/2 ** F = IPI K(a Ipl) 3 where K0, K, are the modified Bessel functions of

Bibliography of Soviet Laser Developments, Number 22, October-December 1975

DTIC Science & Technology

1976-05-17

medium by a resonant monoc.iromatic field. KE, no. 9, 1975, 1985- 1991 . 33 ^^ W ftHUUUI.ipiU i U.iHJilll»ll«llil*i»Hiiiil..»w I 245...V. Pankratov , A. N. Skachkov, and G. V. Shmerling (0). Kinetics of threshold luminescence and bleaching in SF, and BC1., gases...PANASYUK, YE.L 2,45 PANCHENKO, M.V. 35 PANCHENKO, V. YA. 23 PANCHENKO, YU. M. 90 PANFILOV, V. N. 64 PANIN, V.V. 52,80 PANKRATOV , A.V

Numerically Solving a Transient Heat Conduction Problem with Convection and Radiation

DTIC Science & Technology

1993-06-01

AGREE W1 DISAGREE W1 DISAGREE STRONGLY AGREE RESERVATION RESERVATION DISAGREE COMMENT: Synonyms: Antonyms: 91 INDUSTRIAL PLANT EQUIPMENT (IPI) Plant ... Plant equipment acquired by the Government, exceeding an established acquisition cost threshold, used for the purpose of cutting, abrading, grinding...Antonyms: None Survey Results Industrial Plant Equipment First Round 60% 51.X In C 40%0 Q cc 4- 30% -28.2% 0 4-, 0) 20% U 10% 2.6% 2.6s BA A AR DR D

A STUDY OF PSYCHIATRIC ASPECTS OF HYSTERECTOMY

PubMed Central

Vyas, J.N.; Rathore, R.S.; Sharma, P.; Singhal, A.K.

1989-01-01

SUMMARY Thirty women patients who were hysterectomized for non-malignant pathologies were compared with thirty comparable patients who underwent other gynaecological operations. Each patient was subjected to semistructured psychiatric interview, standardised Hindi version of G.H.Q., Hindi version of PEN, I.P.I.S. and BDRI. The diagnosis was made according to I.C.D. - 9. It was observed that patients undergoing hysterectomy do suffer significantly higher psychiatric morbidity (60%), had higher G.H.Q. and BDRI scores at the time of discharge from hospital. PMID:21927363

Comprehensive Ionospheric Polar and Auroral Observations for Solar Minimum of Cycle 23/24

NASA Astrophysics Data System (ADS)

Sojka, Jan J.; Nicolls, Michael; van Eyken, Anthony; Heinselman, Craig

Only the incoherent scatter radar (ISR) is able to simultaneously measure full profiles of elec-tron density, ion temperature, and electron temperatures through the E-and F-layers of the terrestrial ionosphere. Historically ISR's have been operated for periods much less than a month. Hence, their measurements do not constitute a continuous sequence from which quiet, disturbed, and storm periods can reliably be discerned. This is particularly true in the auroral and polar regions. During the International Polar Year (IPY) two ISRs achieved close to 24/7 continuous observations. This presentation describes their data sets and specifically how they can provide the IRI with a fiduciary E-and F-region ionosphere descriptions for solar minimum conditions at auroral and polar cap locations. The ionospheric description being electron den-sity, ion temperature, electron temperature, and even molecular ion composition profiles from as low as 90 km extending several scale heights above the F-layer peak. The auroral location is Poker Flat in Alaska at 65.4° N, 147.5° W where the NSF's new Poker Flat Incoherent Scatter Radar (PFISR) is located. During solar minimum conditions this location is in the auroral region for most of the day and is at mid-latitudes, equatorward of the cusp, for about 4 to 8 hours per day dependent upon geomagnetic activity. In contrast the polar location is Svalbard, at 78° N, 16° E where the EISCAT Svalbard Radar (ESR) is located. For most of the day the ESR is in the Northern Polar Cap often with a noon sector passage through the dayside cusp. Of unique relevance to IRI is that these extended observations have enabled the ionospheric morphology to be demarked between quiet and disturbed. During the IPY year, 1 March 2007 to 29 February 2008, a total of 50 solar wind corotating interaction regions (CIRs) impacted geospace. Each CIR has a one-to-three day geomagnetic disturbance that is observed in the ISR auroral and polar observations. Hence, this data set enables the quiet-background ionosphere to be established as a function of season and local time. This quiet-background ionosphere has the unique attribute that it has self-consistent altitude profiles of the density and the temper-ature. This we believe is a true fiduciary reference for the IRI in a high latitude region, that is otherwise particularly difficult to quantify.

Subglacial Antarctic Lake Environment Research in the IPY

NASA Astrophysics Data System (ADS)

Kennicutt, M. C.; Priscu, J. C.

2006-12-01

Subglacial environments are continental-scale phenomena that occur under thick ice sheets. These environments differ in geologic setting, age, evolutionary history, and limnological conditions and may be connected by sub-ice hydrologic systems. Evidence suggests that subglacial lakes are linked to the onset of ice streams influencing the dynamics of overlying ice sheets. Outbursts of fresh water from subglacial environments have been invoked as an agent of landscape change in the past and there is speculation that subglacial freshwater discharges have influenced past climate. Subglacial environments rest at the intersection of continental ice sheets and the underlying lithosphere. The distribution of subglacial lakes is determined by the availability of water and basins for it to collect in. The distribution of water in subglacial environments is related to surface temperature, accumulation rates, ice thickness, ice velocities, and geothermal flux. The interconnectedness of these environments exerts a fundamental influence on subglacial physical, chemical, and ecological environments; the degree of isolation; and the evolution of life. Subglacial hydrology at a continental-scale must be mapped and modeled to evaluate past drainage events, map subglacial water, and quantify subglacial discharges. The geologic records of past hydrologic events will be reveal the impact of hydrological events on sediment distribution and landscape evolution. Subglacial environments are "natural" earth-bound macrocosms. In some instances these environments trace their origins to more than 35 million years before present when Antarctica became encased in ice. As opposed to other habitats on Earth, where solar energy is a primary influence, processes in subglacial environments are mediated by the flow of the overlying ice a glacial boundary condition and the flux of heat and possibly fluids from the underlying basin a tectonic control. Recent findings suggest that a third control on these environments is subglacial hydrology, which will influence water residence time and the delivery of water, materials, and heat to and through subglacial systems. Owing to the lack of solar energy, any microbiological metabolism in these systems must rely on energy and nutrition derived from glacial ice, the bedrock, and/or geothermal sources. For millions of years, many Antarctic subglacial environments have been insulated from weather, the seasons, and celestially controlled climatic changes that establish fundamental constraints on the structure and functioning of most other ecosystems. Subglacial environments provide an opportunity to advance understanding of how life, the environment, climate, and planetary history combine to produce the world as we know it today. Multi-national, interdisicplinary field campaigns during the IPY 2007-2008 will provide fundamental knowledge about the importance of subglacial environments during the history and evolution of Antarctica.

Polar Science Weekend: A University / Science Center Collaboration

NASA Astrophysics Data System (ADS)

Stern, H. L.; Moritz, R. E.; Lettvin, E.; Schatz, D.; Russell, L.

2008-12-01

Polar Science Weekend (PSW) is a four-day event featuring hands-on activities, live demonstrations, and a variety of exhibits about the polar regions and current polar research, presented by scientists from the University of Washington's Polar Science Center, and held at Seattle's Pacific Science Center. PSW was conceived and organized jointly by the Polar Science Center and Pacific Science Center, which is Washington State's most well-attended museum. The first PSW in March 2006 drew over 5000 visitors, and subsequent PSWs in 2007 and 2008 have both surpassed that figure. The success of this university / science center partnership has made PSW an annual event, and has served as a model for Pacific Science Center's Portal to the Public program, in which partnerships with other scientific institutions have been built. Researchers at the Polar Science Center (PSC) study the physical processes controlling high-latitude oceans, atmosphere, sea ice, and ice sheets, and are involved in numerous IPY projects. PSC scientists also engage in many outreach efforts such as classroom visits and public lectures, but PSW stands out as the highlight of the year. The partnership with Pacific Science Center brings access to facilities, publicity, and a large audience that would not otherwise be readily available to PSC. Pacific Science Center, constructed for the 1962 World's Fair in Seattle, serves more than one million visitors per year. Pacific Science Center's mission is to inspire a lifelong interest in science, math and technology by engaging diverse communities through interactive and innovative exhibits and programs. PSW helps to advance this mission by bringing students, teachers, and families face-to-face with scientists who work in some of the most remote and challenging places on earth, to learn first-hand about polar research in a fun and informal setting. This is made possible only by the partnership with PSC. In this talk we will present descriptions and photos of PSW activities and exhibits such as Smashing Ice, Glacier Flow, and the Salinity Taste Test. We will also discuss the organizational effort behind PSW, including the recruiting of volunteers and sponsors, publicity, and funding. Finally, we will comment on the elements that make for a successful collaboration. PSW 2009 is scheduled for February 26 through March 1. For more information, visit http://psc.apl.washington.edu/psw/.

Disseminated Museum Displays and Participation of Students from Underrepresented Populations in Polar Research: Education and Outreach for Joint Projects in GPS and Seismology Solid Earth Science Community

NASA Astrophysics Data System (ADS)

Eriksson, S. C.; Wilson, T. J.; Anandakrishnan, S.; Aster, R. C.; Johns, B.; Anderson, K.; Taber, J.

2006-12-01

Two Antarctic projects developed by solid earth scientists in the GPS and seismology communities have rich education and outreach activities focused on disseminating information gleaned from this research and on including students from underrepresented groups. Members of the UNAVCO and IRIS research consortia along with international partners from Australia, Canada, Chile, Germany, Italy, New Zealand and the U.K. aim to deploy an ambitious GPS/seismic network to observe the Antarctic glaciological and geologic system using a multidisciplinary and internationally coordinated approach. The second project supports this network. UNAVCO and IRIS are designing and building a reliable power and communication system for autonomous polar station operation which use the latest power and communication technologies for ease of deployment and reliable multi-year operation in severe polar environments. This project will disseminate research results through an IPY/POLENET web-based museum style display based on the next-generation "Museum Lite" capability primarily supported by IRIS. "Museum Lite" uses a standard PC, touch-screen monitor, and standard Internet browsers to exploit the scalability and access of the Internet and to provide customizable content in an interactive setting. The unit is suitable for research departments, public schools, and an assortment of public venues, and can provide wide access to real-time geophysical data, ongoing research, and general information. The POLENET group will work with members of the two consortia to provide content about the project and polar science in general. One unit is to be installed at Barrow's Ilisagvit College through the Barrow Arctic Science Consortium, one at McMurdo Station in Antarctica, and two at other sites to be determined (likely in New Zealand/Australia and in the U.S.). In January, 2006, Museum Lite exhibit was installed at the Amundsen-Scott South Pole Station. Evaluation of this prototype is underway. These projects also have a special focus on engaging underrepresented groups in polar science through coalitions with existing recruitment networks and strong, currently operating programs such as the joint UNAVCO-IRIS-USGS program called Research Experiences in Solid Earth Science for Students (RESESS) that provides multi-year research experiences, ongoing mentorship, and a learning community. Undergraduate students will participate in polar research or in development of the new polar equipment.

The Future of Systems Aeronomy in Addressing New Science Frontiers

NASA Astrophysics Data System (ADS)

Kozyra, J. U.; Paxton, L. J.; Ridley, A.

2005-12-01

The future will see a new era in our ability to characterize the state of the sun-Earth system using the SEC Great Observatory, new electronic data handling and data mining technologies, high-performance sun-to-Earth models, new techniques for assimilation of sparse data, and the development of innovative worldwide research tools through integration of ground-based observing sites. The time has come to pull these developing capabilities together into an investigation that seeks to understand aeronomy at a higher level than has previously been possible. Systems Aeronomy is a study of this global system behavior but, more than that, it investigates the large-scale systems-level features that result from elemental processes, like ion-neutral coupling, plasma drifts or radiative cooling. Currently the TIMED mission is making important contributions in identifying and characterizing the "building block" processes that change, evolve and combine to form the system response. Systems Aeronomy must have observational, theoretical and computational components to succeed. One of the key requirements is the ability to capture global data sets and integrate them into a coherent picture of the ITM system and its relationship to geospace. Success requires enhanced coordination between operating satellites throughout the sun-Earth system, new techniques for creating global maps from networks of ground-based and satellite-based sensors, and a new level of international cooperation leveraging off IPY2007, IHY2007, eGY2007, CAWSES, ICESTAR, and other planned worldwide programs. Twenty years down the road, Systems Aeronomy will provide the foundation for understanding planetary atmospheres, significantly extend the range of useful space weather prediction, and provide an important approach for investigating the impacts of anthropogenic and climatological changes in the ITM and on the geospace system as a whole.

Human Health Risks Associated with Metals from Urban Soil and Road Dust in an Oilfield Area of Southeastern Algeria.

PubMed

Benhaddya, Mohammed Lamine; Boukhelkhal, Abdelaziz; Halis, Youcef; Hadjel, Mohammed

2016-04-01

Hassi Messaoud town is a recent city that is situated inside the oil field, which hosts an important petroleum extraction field and refinery. Large-scale and long-term oil refinery and corresponding industrial activities may contaminate the surrounding soil/dust and could lead to pollution levels that can affect human health. The soil and road dust samples were analysed for different trace elements: copper (Cu), manganese (Mn), nickel (Ni), lead (Pb), and zinc (Zn). Geo-accumulation index (I(geo)), pollution index (PI), and integrated pollution index (IPI) were calculated to evaluate the heavy metal contamination level of urban soil and road dust. The I(geo) values indicate unpolluted to moderate polluted of investigated metals in the soil samples. The assessment results of PI support the results of I(geo), and IPI indicates heavy metals in road dust polluted seriously. The noncarcinogenic health risk assessment shows that ingestion of soil/dust particles is the route for exposure to heavy metals, followed by dermal adsorption. The human exposure risk assessment based on different exposure pathways showed that the hazard index (HI) was <1.0 for all of the elements. The relative exposure risk (noncarcinogenic) was greater for toddlers. Although the overall risk was within the acceptable limit of 1.00, the HI of Pb from the soil (0.103) and road dust (0.132) was close to the threshold limits, which over the long-term may pose a health risk.

Assessment of heavy metal pollution in surface soils of urban parks in Beijing, China.

PubMed

Chen, Tong-Bin; Zheng, Yuan-Ming; Lei, Mei; Huang, Ze-Chun; Wu, Hong-Tao; Chen, Huang; Fan, Ke-Ke; Yu, Ke; Wu, Xiao; Tian, Qin-Zheng

2005-07-01

Assessing the concentration of potentially harmful heavy metals in the soil of urban parks is imperative in order to evaluate the potential risks to residents and tourists. To date, little research on soil pollution in China's urban parks has been conducted. To identify the concentrations and sources of heavy metals, and to assess the soil environmental quality, samples were collected from 30 urban parks located in the city of Beijing. Subsequently, the concentrations of Cu, Ni, Pb and Zn in the samples were analyzed. The investigation revealed that the accumulations of Cu and Pb were readily apparent in the soils. The integrated pollution index (IPI) of these four metals ranged from 0.97 to 9.21, with the highest IPI in the densely populated historic center district (HCD). Using multivariate statistic approaches (principal components analysis and hierarchical cluster analysis), two factors controlling the heavy metal variability were obtained, which accounted for nearly 80% of the total variance. Nickel and Zn levels were controlled by parent material in the soils, whereas Cu, Pb and, in part, Zn were accounted for mainly by anthropogenic activities. The findings presented here indicate that the location and the age of the park are important factors in determining the extent of heavy metal, particularly Cu and Pb, pollution. In addition, the accumulation of Zn did not appear to reach pollution levels, and no obvious pollution by Ni was observed in the soils of the parks in Beijing.

Heavy Metal Pollution in Settled Dust Associated with Different Urban Functional Areas in a Heavily Air-Polluted City in North China.

PubMed

Wan, Dejun; Han, Zhangxiong; Yang, Jinsong; Yang, Guanglin; Liu, Xingqi

2016-11-10

Understanding variations of heavy metals in atmospheric particles between different functional areas is significant for pollution control and urban planning in cities. To reveal pollution and spatial distribution of heavy metals in atmospheric particles from different urban functional areas in Shijiazhuang in North China, 43 settled dust samples were collected over the main urban area and heavy metal concentrations were determined in their <63 μm fractions using an ICP-OES. The results suggest that Cr, Mn, Fe, Co, Ni, and V in the dust are not or slightly enriched and their concentrations vary slightly between different sites, implying their natural origins; whereas Cu, Zn, Cd, and Pb are often notably enriched and their concentrations vary significantly between different functional areas, indicating their anthropogenic sources. Integrated pollution indexes (IPIs) of the ten heavy metals are 2.7-13.6 (5.7 ± 2.2), suggesting high or very high pollution levels of most dust. Relatively lower IPIs occur mainly in the administration-education area, the commercial area, and other unclassified sites; while peaks occur mainly in the North Railway Station, the northeastern industrial area, and some sites near heavily trafficked areas, implying the significant influence of intensive industrial (including coal combustion) and traffic activities on atmospheric heavy metal accumulation. These results suggest a clear need of mitigating atmospheric heavy metal pollution via controlling emissions of toxic metals (especially Cd and Pb) from industrial and traffic sources in the city.

Heavy Metal Pollution in Settled Dust Associated with Different Urban Functional Areas in a Heavily Air-Polluted City in North China

PubMed Central

Wan, Dejun; Han, Zhangxiong; Yang, Jinsong; Yang, Guanglin; Liu, Xingqi

2016-01-01

Understanding variations of heavy metals in atmospheric particles between different functional areas is significant for pollution control and urban planning in cities. To reveal pollution and spatial distribution of heavy metals in atmospheric particles from different urban functional areas in Shijiazhuang in North China, 43 settled dust samples were collected over the main urban area and heavy metal concentrations were determined in their <63 μm fractions using an ICP-OES. The results suggest that Cr, Mn, Fe, Co, Ni, and V in the dust are not or slightly enriched and their concentrations vary slightly between different sites, implying their natural origins; whereas Cu, Zn, Cd, and Pb are often notably enriched and their concentrations vary significantly between different functional areas, indicating their anthropogenic sources. Integrated pollution indexes (IPIs) of the ten heavy metals are 2.7–13.6 (5.7 ± 2.2), suggesting high or very high pollution levels of most dust. Relatively lower IPIs occur mainly in the administration-education area, the commercial area, and other unclassified sites; while peaks occur mainly in the North Railway Station, the northeastern industrial area, and some sites near heavily trafficked areas, implying the significant influence of intensive industrial (including coal combustion) and traffic activities on atmospheric heavy metal accumulation. These results suggest a clear need of mitigating atmospheric heavy metal pollution via controlling emissions of toxic metals (especially Cd and Pb) from industrial and traffic sources in the city. PMID:27834903

Observed OH and HO2 concentrations in the upper troposphere inside and outside of Asian monsoon influenced air.

NASA Astrophysics Data System (ADS)

Marno, D. R.; Künstler, C.; Hens, K.; Tatum Ernest, C.; Broch, S.; Fuchs, H.; Martinez, M.; Bourtsoukidis, E.; Williams, J.; Holland, F.; Hofzumahaus, A.; Tomsche, L.; Fischer, H.; Klausner, T.; Schlager, H.; Eirenschmalz, L.; Stratmann, G.; Stock, P.; Ziereis, H.; Roiger, A.; Bohn, B.; Zahn, A.; Wahner, A.; Lelieveld, J.; Harder, H.

2016-12-01

The Asian monsoon convectively transports pollutants like volatile organic compounds (VOCs), NOx, and SO2 from the boundary layer over South Asia into the upper troposphere where they can potentially enter the stratosphere, or be dispersed globally. Therefore, it is crucial to understand the oxidizing capacity of this system regarding the rate of aerosol formation, and conversion of pollutants into compounds that have much shorter atmospheric lifetimes. OH plays a central role in this oxidation process. During the OMO-ASIA campaign in the summer of 2015, OH and HO2 were measured onboard the High Altitude Long-Range (HALO) Research Aircraft. Two laser-induced fluorescence instruments based on the fluorescence assay by gas expansion technique (LIF-FAGE) had been deployed, the AIR-LIF instrument from Forschungszentrum Jülich GmbH and the HORUS instrument from the Max Planck Institute for Chemistry, Mainz. To measure the chemical background of OH potentially produced inside the HORUS instrument from highly oxidized VOCs, atmospheric OH is scavenged by an Inlet Pre-injector (IPI) system. This was the first time an IPI system was implemented within an airborne LIF-FAGE instrument measuring OH and HO2. Throughout this campaign OH and HO2 were measured at 12 to 15km within the Asian monsoon anticyclone. These measurements have been contrasted by probing air outside the anticyclone in air masses influenced by North American emissions, and in very clean air masses originated from the southern hemisphere.

Acceptance Test Data for Candidate AGR-5/6/7 TRISO Particle Batches BWXT Coater Batches 93165 93172 Defective IPyC Fraction and Pyrocarbon Anisotropy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Helmreich, Grant W.; Hunn, John D.; Skitt, Darren J.

2017-03-01

Coated particle fuel batches J52O-16-93165, 93166, 93168, 93169, 93170, and 93172 were produced by Babcock and Wilcox Technologies (BWXT) for possible selection as fuel for the Advanced Gas Reactor Fuel Development and Qualification (AGR) Program’s AGR-5/6/7 irradiation test in the Idaho National Laboratory (INL) Advanced Test Reactor (ATR). Some of these batches may alternately be used as demonstration coated particle fuel for other experiments. Each batch was coated in a 150-mm-diameter production-scale fluidized-bed chemical vapor deposition (CVD) furnace. Tristructural isotropic (TRISO) coatings were deposited on 425-μm-nominal-diameter spherical kernels from BWXT lot J52R-16-69317 containing a mixture of 15.5%-enriched uranium carbide andmore » uranium oxide (UCO). The TRISO coatings consisted of four consecutive CVD layers: a ~50% dense carbon buffer layer with 100-μm-nominal thickness, a dense inner pyrolytic carbon (IPyC) layer with 40-μm-nominal thickness, a silicon carbide (SiC) layer with 35-μm-nominal thickness, and a dense outer pyrolytic carbon (OPyC) layer with 40-μmnominal thickness. The TRISO-coated particle batches were sieved to upgrade the particles by removing over-sized and under-sized material, and the upgraded batches were designated by appending the letter A to the end of the batch number (e.g., 93165A).« less

An Observational Study of Group Waterpipe Use in a Natural Environment

PubMed Central

2014-01-01

Introduction: To date research on tobacco smoking with a waterpipe (hookah, narghile, and shisha) has focused primarily on the individual user in a laboratory setting. Yet, waterpipe tobacco smoking is often a social practice that occurs in cafés, homes, and other natural settings. This observational study examined the behavior of waterpipe tobacco smokers and the social and contextual features of waterpipe use among groups in their natural environment. Methods: Trained observers visited urban waterpipe cafés on multiple occasions during an 8-month period. Observations of 241 individual users in naturally formed groups were made on smoking topography (puff frequency, duration, and interpuff interval [IPI]) and engagement in other activities (e.g., food and drink consumption, other tobacco use, and media viewing). Results: Most users were male in group sizes of 3–4 persons, on average, and each table had 1 waterpipe, on average. The predominant social features during observational periods were conversation and nonalcoholic drinking. Greater puff number was associated with smaller group sizes and more waterpipes per group, while longer IPIs were associated with larger group sizes and fewer waterpipes per group. Additionally, greater puff frequency was observed during media viewing and in the absence of other tobacco use. Conclusions: Overall, the results suggest that waterpipe smoking behavior is affected by group size and by certain social activities. Discussion focuses on how these findings enhance our understanding of factors that may influence exposure to waterpipe tobacco smoke toxicants in naturalistic environments. PMID:23943842

Burnout and the learning environment of anaesthetic trainees.

PubMed

Castanelli, D J; Wickramaarachchi, S A; Wallis, S

2017-11-01

Burnout has a high prevalence among healthcare workers and is increasingly recognised as an environmental problem rather than reflecting a personal inability to cope with work stress. We distributed an electronic survey, which included the Maslach Burnout Inventory Health Services Survey and a previously validated learning environment instrument, to 281 Victorian anaesthetic trainees. The response rate was 50%. We found significantly raised rates of burnout in two of three subscales. Ninety-one respondents (67%) displayed evidence of burnout in at least one domain, with 67 (49%) reporting high emotional exhaustion and 57 (42%) reporting high depersonalisation. The clinical learning environment tool demonstrated a significant negative correlation with burnout (r=-0.56, P <0.001). Burnout was significantly more common than when previously measured in Victoria in 2008 (62% versus 38%). Trainees rated examination preparation the most stressful aspect of the training program. There is a high prevalence of burnout among Victorian anaesthetic trainees. We have shown a significant correlation exists between the clinical learning environment measure and the presence of burnout. This correlation supports the development of interventions to improve the clinical learning environment, as a means to improve trainee wellbeing and address the high prevalence of burnout.

Teaching Outside the Box: Challenging Gifted Students with Polar Sciences Without Benefit of a Science Classroom

NASA Astrophysics Data System (ADS)

Dooley, J.

2013-12-01

In the high-stakes-testing world of one-size-fits-most educational practices, it is often the needs of the most able students that are unmet, yet these high ability learners can benefit greatly from exploration in the area of polar science. With school schedules and budgets already stretched to the breaking point and Common Core (CCSS) subjects are the focus, very few resources remain for topics considered by some as unimportant. Polar and climate science are prime examples. Here, a council member of Polar Educators International and Gifted Education Teacher, shares resources and ideas to engage this unique group of students and others. She draws from experiences and knowledge gained through ANDRILL's Arise Educator program, IPY Oslo and Montreal PolarEDUCATOR workshops, and Consortium for Ocean Leadership's Deep Earth Academy. Topics include School-wide Enrichment through use of ANDRILL's Flexhibit material and participation in Antarctica Day, afterschool Deep Freeze clubs that presented in public outreach venues for polar science events at the Maryland Science Center in Baltimore and NYC's Museum of Natural History, group project work using IODP core data from Antarctica, interaction with polar scientists via Skype, and other projects.

Group Waterpipe Tobacco Smoking Increases Smoke Toxicant Concentration.

PubMed

Ramôa, Carolina P; Shihadeh, Alan; Salman, Rola; Eissenberg, Thomas

2016-05-01

Waterpipe tobacco smoking is a global health concern. Laboratory research has focused on individual waterpipe users while group use is common. This study examined user toxicant exposure and smoke toxicant yield associated with individual and group waterpipe smoking. Twenty-two pairs of waterpipe smokers used a waterpipe individually and as a dyad. Before and after smoking, blood was sampled and expired carbon monoxide (CO) measured; puff topography was recorded throughout. One participant from each pair was selected randomly and their plasma nicotine and expired air CO concentrations were compared when smoking alone to when smoking as part of a dyad. Recorded puff topography was used to machine-produce smoke that was analyzed for toxicant content. There was no difference in mean plasma nicotine concentration when an individual smoked as part of a dyad (mean = 14.9 ng/ml; standard error of the mean [SEM] = 3.0) compared to when smoking alone (mean = 10.0 ng/ml; SEM = 1.5). An individual smoking as part of as a dyad had, on average, lower CO (mean = 15.8 ppm; SEM = 2.0) compared to when smoking alone (mean= 21.3 ppm; SEM = 2.7). When two participants smoked as a dyad they took, on average, more puffs (mean = 109.8; SEM = 7.6) than a singleton smoker (mean = 77.7; SEM = 8.1) and a shorter interpuff interval (IPI; dyad mean = 23.8 seconds; SEM = 1.9; singleton mean = 40.8 seconds; SEM = 4.8). Higher concentrations of several toxicants were observed in dyad-produced smoke. Dyad smoking may increase smoke toxicant content, likely due to the dyad's shorter IPIs and greater puff number. More work is needed to understand if group waterpipe smoking alters the health risks of waterpipe tobacco smoking. This study is the first to measure toxicants in smoke generated from a waterpipe when used by a dyad. Relative to smoke generated by a singleton, dyad smoke had higher concentration of some toxicants. These differences may be attributed to differences in puffing behavior, specifically the shorter IPI and greater puff number observed in the dyad condition. Relative to singleton smokers, dyad smokers were exposed to less CO, but nicotine exposure did not differ. More work is needed to assess the health effects of inhalation of more toxicant-laden smoke during group waterpipe use. © The Author 2015. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Sarcopenia is an independent prognostic factor in elderly patients with diffuse large B-cell lymphoma treated with immunochemotherapy.

PubMed

Lanic, Hélène; Kraut-Tauzia, Jerôme; Modzelewski, Romain; Clatot, Florian; Mareschal, Sylvain; Picquenot, Jean Michel; Stamatoullas, Aspasia; Leprêtre, Stéphane; Tilly, Hervé; Jardin, Fabrice

2014-04-01

Approximately 25-35% of patients with diffuse large B-cell lymphoma (DLBCL) are older than 70 years. The aim of this study was to investigate the prognostic impact of depletion of skeletal muscle (sarcopenia) in elderly patients with DLBCL. This retrospective analysis included 82 patients with DLBCL older than 70 years and treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, Oncovin, prednisone) or R-miniCHOP. Sarcopenia was measured by the analysis of stored computed tomography (CT) images at the L3 level at baseline. The surface of the muscular tissues was selected according to the CT Hounsfield unit. This value was normalized for stature in order to calculate the lumbar L3 skeletal muscle index (LSMI, in cm(2)/m(2)). The mean age of the population was 78 years. According to the defined cut-offs for LSMI, 45 patients with DLBCL were considered sarcopenic. Sarcopenic patients displayed a higher revised International Prognostic Index (R-IPI) compared with patients without sarcopenia, and were older, with a mean age of 80 years and 77 years, respectively (p = 0.006). With a median follow-up of 39 months, the 2-year overall survival in the sarcopenic population was 46% compared with 84% in the non-sarcopenic group (HR = 3.22; 95% CI = 1.73-5.98; p = 0.0002). In a multivariate analysis, sarcopenia remained predictive of outcome (p = 0.005). Sarcopenia is a relevant and predictive factor in elderly patients with DLBCL treated with rituximab plus chemotherapy.

Technology Insertion (TI)/Industrial Process Improvement (IPI) Task Order Number 1. Data Base Documentation Book for WR-ALC/MANPSC (Bonded Honeycomb)

DTIC Science & Technology

1989-08-14

for a long time In getting those required parts. 6-29-89 VR-ALC Model Validation Heeting Minutes Page Seven MANPSB • This Is a manufacturing RCC. • No...Manpower. 4. Training shop - mechanics get transferred to r-15 Shop. Ninutes of Brainstorming Session June 20. 1969 Horning Session Page Two 5. Two shifts...11. RCC KANPSB completes then ships to storage - delay 10 to 15 days to get the same part back In finlshing the repair. 12. Major repair coordination

Ninety Years of International Cooperation in Geophysics

NASA Astrophysics Data System (ADS)

Ismail-Zadeh, A.; Beer, T.

2009-05-01

Because applicable physical, chemical, and mathematical studies of the Earth system must be both interdisciplinary and international, the International Union of Geodesy and Geophysics (IUGG) was formed in 1919 as an non-governmental, non-profit organization dedicated to advancing, promoting, and communicating knowledge of the Earth system, its space environment, and the dynamical processes causing change. The Union brings together eight International Associations that address different disciplines of Earth sciences. Through these Associations, IUGG promotes and enables studies in the geosciences by providing a framework for collaborative research and information exchange, by organizing international scientific assemblies worldwide, and via research publications. Resolutions passed by assemblies of IUGG and its International Associations set geophysical standards and promote issues of science policy on which national members agree. IUGG has initiated and/or vigorously supported collaborative international efforts that have led to highly productive worldwide interdisciplinary research programs, such as the International Geophysical Year and subsequent International Years (IPY, IYPE, eGY, and IHY), International Lithosphere Programme, World Climate Research Programme, Geosphere-Biosphere Programme, and Integrated Research on Risk Disaster. IUGG is inherently involved in the projects and programs related to climate change, global warming, and related environmental impacts. One major contribution has been the creation, through the International Council for Science (ICSU), of the World Data Centers and the Federation of Astronomical and Geophysical Data Analysis Services. These are being transformed to the ICSU World Data System, from which the data gathered during the major programs and data products will be available to researchers everywhere. IUGG cooperates with UNESCO, WMO, and some other U.N. and non-governmental organizations in the study of natural catastrophes, climate dynamics, and in geodetic, hydrological, meteorological, oceanographic, seismological, and volcanological research. IUGG also places particular emphasis on the scientific problems of economically less-developed countries by sponsoring activities relevant to their scientific needs (e.g. Geosciences in Africa, Water Resources, Health and Well-Being etc.) The American Geophysical Union was established as the U.S. National Committee for IUGG in 1919 and today has become a distinguished union of individual geoscientists around the world. Several regional geoscience societies also evolved during the last several decades, most prominent being the European Geosciences Union and the Asia Oceania Geosciences Society. These, and some other national and regional geophysical societies, together with IUGG play a strong part in the international cooperation and promotion of geophysical sciences. At the same time the "geosciences" space is getting crowded, and there is a lot of overlap. International linkages between IUGG, AGU, EGU and other geophysical societies as well as their linkage with International Scientific Unions, that comprise the GeoUnions, are going to become more and more important. Working together is going to be more fruitful than territorial disputes. But what mechanisms can be used to encourage relationships between the international, national and regional geophysical and geoscientific bodies? We will discuss some possibilities on how to come together, to develop and to implement joint programs, research meeting, open forums, and policy statements.

Special report. Designing security for a garage serving a new medical school: from concept to reality.

PubMed

1997-01-01

The Paterson Street Deck, New Brunswick, NJ, cited by the International Parking Institute (IPI) for excellence in design, employs a number of modern security concepts to protect its customers. The deck was built by the New Brunswick Parking Authority, which worked with the city's medical community to develop the 1,010-space structure located next to the newly built Robert Wood Johnson Medical School. The spaces are used by approximately 800 medical patrons--students of the medical school and employees of Robert Wood Johnson University Hospital, as well as an additional 200 visitors. Staffers and students pay for parking services biweekly on a graduated scale based on the level of their job title, according to Joseph Bernasz, director of administrator, Robert Wood Johnson Medical School. And they have been very receptive to the new facility, says Kevin McTernan, vice president of administrative services, Robert Wood Johnson University Hospital, New Brunswick. In this report, we'll present in detail the security concepts employed, the reasons behind them, and how they have been employed since the deck opened about two years ago.

Attachment hierarchies for Spanish adolescents: family, peers and romantic partner figures.

PubMed

Viejo, Carmen; Monks, Claire P; Sánchez-Rosa, María; Ortega-Ruiz, Rosario

2018-04-26

Attachment Theory has become one of the leading theories in human development. Nonetheless, empirical studies focusing on how attachment unfolds during adolescence are still scarce particularly in Spain, due to the lack of adequate measures. This study aims to validate the Important People Interview (IPI) in a shorter questionnaire version (Important People- Questionnaire; IP-Q); to analyse the changes in different affiliative bonds to multiple figures -family, peers, romantic partners - over the course of adolescence; and to identify boys' and girls' hierarchical ordering of their specific attachment bonds. 1025 Spanish adolescents, aged 12-17 years old completed the IP-Q. The results showed that the IP-Q has convergent and divergent validity. Moreover, this measure indicated that peers overtake some family members in proximity-seeking and support-seeking, but not in the overall hierarchical ordering of the attachment bond during adolescence. The bond with the romantic partner increases in terms of scoring on the affiliative subscales as adolescence progresses. There are significant gender differences among the hierarchy patterns of attachment for boys and girls. Developmental changes in adolescent attachment are discussed.

The Unmanned Aerial System SUMO: an alternative measurement tool for polar boundary layer studies

NASA Astrophysics Data System (ADS)

Mayer, S.; Jonassen, M. O.; Reuder, J.

2012-04-01

Numerical weather prediction and climate models face special challenges in particular in the commonly stable conditions in the high-latitude environment. For process studies as well as for model validation purposes in-situ observations in the atmospheric boundary layer are highly required, but difficult to retrieve. We introduce a new measurement system for corresponding observations. The Small Unmanned Meteorological Observer SUMO consists of a small and light-weight auto-piloted model aircraft, equipped with a meteorological sensor package. SUMO has been operated in polar environments, among others during IPY on Spitsbergen in the year 2009 and has proven its capabilities for atmospheric measurements with high spatial and temporal resolution even at temperatures of -30 deg C. A comparison of the SUMO data with radiosondes and tethered balloons shows that SUMO can provide atmospheric profiles with comparable quality to those well-established systems. Its high data quality allowed its utilization for evaluation purposes of high-resolution model runs performed with the Weather Research and Forecasting model WRF and for the detailed investigation of an orographically modified flow during a case study.

A Danish population-based analysis of 105 mantle cell lymphoma patients: incidences, clinical features, response, survival and prognostic factors.

PubMed

Andersen, N S; Jensen, M K; de Nully Brown, P; Geisler, C H

2002-02-01

This study presents the first large clinical analysis of 105 unselected mantle cell lymphoma (MCL) patients diagnosed from 1992 to 2000 in a well-defined Danish population. The annual incidences were 0.7/100000 for men and 0.2/100000 for women, with no significant change during the study period. Of 97 evaluable cases, 43% achieved a complete response (CR) after initial therapy. The median disease-free (DFS) and overall survival (OS) rates were 15 and 30 months, respectively. In multivariate analysis, splenomegaly (P=0.002), anaemia (P=0.0001) and age (P=0.002), but not the international prognostic index (IPI) and the Ann Arbor staging system, had an independent impact on survival. Moreover, in a sub-analysis of 45 younger MCL patients (<65 years), a trend towards an OS plateau of 58% was observed in cases without splenomegaly and anaemia (n=29). Thus, in contrast to previously suggested prognostic factors, these variables may prove useful for clinical decisions in a significant subset of MCL patients.

The 33rd IGC, Oslo, Norway 2008; Geoscience World Congress 2008

NASA Astrophysics Data System (ADS)

Solheim, A.; Bjoerlykke, A.

2007-12-01

The International Geological Congress (IGC) has been arranged every four years since 1878. During the previous Congress in Florence, Italy, 2004, the Nordic countries were awarded the organisation of the 33rd IGC, which will be held in Oslo, Norway, August 6-14, 2008. We expect between 6000 and 9000 participants to the Congress, which also includes workshops, short-courses, and business meetings, as well as more than 50 pre -and post Congress excursions. The Congress is organised under the umbrella of IUGS and the patronage of UNESCO. The Congress will run with 40 parallel sessions and cover the whole width of the geosciences. About 500 symposia will run in 40 parallel sessions. There will be a major poster session, as well as a large exhibition (Geoexpo 2008), in which industry and other organisations will be able to exhibit their products and services. A number of international affiliations have announced their interest in organising annual business meetings during the Congress. In addition, a number of workshops and short-courses will be arranged. More than 50 excursions are planned for the two weeks before the Congress and one week after. These run in all the Nordic Countries, as well as in NW Russia, Ukraine, Greenland, Svalbard, and the Faeroes Islands. These excursions will give the participants a first-hand insight into Nordic Geosciences, as well as the Nordic natural and cultural heritage. Two major international events are important for the Congress. The "International Polar Year" (IPY) and the United Nations' "International Year of Planet Earth" (IYPE) are both running in the period 2007-2009. The Congress focuses on many of the main themes of IYPE, with major emphasis on "Geoscience and Society". Seven major themes will be treated in full-day plenary sessions of lectures given by invited lecturers. These plenary sessions will have a scientific part in the morning, a key-note lecture at lunch-time, and a societal part in the afternoon, followed by a plenary debate. The themes comprise Biodiversity and the geo-environment; Climate change, past, present, future; Geohazards and human behaviour; Water, human health, and the environment; Mineral resources in a fast growing global economy; The energy race - what will be the future energy mix?; Earth and beyond - synergies between Earth and planetary sciences. Nordic ministers are invited to participate in panel debates and press conferences related to these "Themes of the day". In relation to the IPY, the Arctic will receive particular attention, which is important since the effects of climate change is seen first and expected to be largest in these regions. With its focus on climate issues, the Congress will contribute with state-of-the-art science and thereby to the general debate on these issues. Information on all aspects of the programme iscontinuously updated on the Congress website: www.33igc.org.

Last deglaciation of the Svalbard/Barents Sea Ice Sheet - a swath bathymetric and sub-bottom seismic study from the Kveithola Trough

NASA Astrophysics Data System (ADS)

Rebesco, Michele; Liu, Yanguang; Camerlenghi, Angelo; Winsborrow, Monica; Sverre Laberg, Jan; Caburlotto, Andrea; Diviacco, Paolo; Accettella, Daniela; Sauli, Chiara; Wardell, Nigel

2010-05-01

Kveithola Trough, an E-W trending cross-shelf glacial trough in the NW Barents Sea, was surveyed for the first time during the EGLACOM cruise between 8th July and 4th August 2008 on board R/V OGS-Explora. EGLACOM (Evolution of a GLacial Arctic COntinental Margin: the southern Svalbard ice stream-dominated sedimentary system) project is the Italian contribution to the International Polar Year (IPY) Activity 367 (Neogene ice streams and sedimentary processes on high- latitude continental margins - NICE STREAMS). Such IPY activity included as well the Spanish SVAIS 2008 cruise on board BIO Hesperides. EGLACOM data acquisition, focused on the Storfjorden Fan and Kveithola Trough, included a multi-channel seismic (MCS) reflection survey and the simultaneous collection of swath bathymetry and sub-bottom CHIRP profiles. Swath bathymetry in the Kveithola Trough shows that the seafloor is characterized by E-W trending mega-scale glacial lineations (MSGL). These include large-scale ridges about 2 km wide and 15 m high as well as smaller grooves about 100 m wide and a few metres deep. Such MSGL record the fast flow of an ice stream draining the Svalbard/Barents Sea Ice Sheet (SBSIS) during the Last Glacial Maximum (LGM). MSGL are overprinted by transverse sediment ridges about 15 km apart which give rise to a staircase long profile of the trough. Such transverse ridges are interpreted as grounding-zone wedges (GZW) formed by deposition of unconsolidated, saturated subglacial till during ice stream retreat. Sub-bottom (CHIRP) and multi-channel reflection seismic data show that the morphology is controlled by stacked sets of lensoidal transparent units (tills) overlain by a draping glaciomarine unit up to over 15 m thick. Formed during temporary stillstands in grounding-zone position before complete deglaciation, GZW ridges are diagnostic of episodic retreat. Our data allow the reconstruction of deglaciation in the Spitsbergen Bank area, with each stage during deglaciation recorded by deposition of a GZW. Three independent lines of reasoning suggest that an ice cap persisted on Spitsbergen Bank for some thousand years and lasted much longer than those that fed the adjacent glacial troughs: 1) the freshness of the morphology in Kveithola Trough compared to that of adjacent Storfjorden and Bear Island troughs; 2) the volume of sediment in the GZW ridges compared to the small catchment area; 3) preliminary assessment of the stratigraphic position of debris flow deposits on the continental slope. The 15 m of sedimentary drape deposited on top of GZW ridges contains a high-resolution palaeoclimatic record of the last thousand years, which accumulated at a very high average sedimentation rate. Sampling (through drilling) of the thin glaciomarine sediments between the till lenses of the successive GZW ridges may allow the dating of deglaciation phases in the Barents Sea.

Libre: Freeing Polar Data in an Information Commons

NASA Astrophysics Data System (ADS)

Duerr, R. E.; Parsons, M. A.

2010-12-01

As noted in the session description “The polar regions are at the forefront of modern environmental change, currently experiencing the largest and fastest changes in climate and environment”. Wise use of resources, astute management of our environment, improved decision support, and effective international cooperation on natural resource and geopolitical issues require a deeper understanding of, and an ability to predict change and its impact. Understanding and knowledge are built on data and information, yet polar information is scattered, scarce, and sporadic. Rapid change demands rapid data access. We envision a system where investigators quickly expose their data to the world and share them, without restriction, through open protocols on the Internet. A single giant, central archive is not practical for all polar data held around the world. Instead, we seek a collaborative, virtual space, where scientific data and information could be shared ethically and with minimal constraints. Inspired by the Antarctic Treaty of 1959 that established the Antarctic as a global commons to generate greater scientific understanding, the International Council of Science leads the Polar Information Commons (PIC). The PIC, engendered by the International Polar Year (IPY) and work on the IPY data policy, serves as an open, virtual repository for vital scientific data and information. An international network of scientific and data management organizations concerned with the scientific quality, integrity, and stewardship of data is developing the PIC. The PIC utilizes the Science Commons Protocol for Implementing Open Access Data, including establishment of community norms to encourage appropriate contributions to and use of PIC content. Data descriptions (metadata) are not necessarily registered in formal repositories or catalogues. They may simply be exposed to search engines or broadcast through syndication services such as RSS or Atom. The data are labeled or branded as part of the PIC and are, therefore, open for use without restriction. The PIC label also alerts data centers around the world to new polar data. These data centers then assess and acquire important data for formal archiving, curation, and access through national and global data systems. The intent is to enable rapid data access without qualification, while establishing a process for long-term preservation and stewardship of critical data. This paper will review the ethical and legal basis for sharing polar data and information, as well as the technologies being employed to make the PIC a reality.

Diffuse thyroid 18F-FDG uptake after R-CHOP therapy predicts favorable outcome in patients with DLBCL.

PubMed

Song, Moo-Kon; Chung, Joo-Seop; Kim, Seong-Jang; Kim, Sang-Soo; Shin, Ho-Jin

2015-06-01

Therapy-induced autoimmunity may mediate the destruction of cancer cells. Previous studies have demonstrated that presence of autoimmune thyroid disorder is associated with favorable outcome in patients with solid cancer. Patients with diffuse large B cell lymphoma (DLBCL) who achieved complete response on positron emission tomography/computed tomography (PET/CT) after rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy were enrolled in this study. The patients with and without diffuse thyroid uptake (DTU) were classified by PET/CT. A total of 270 patients were enrolled in this study. DTU related to autoimmune thyroiditis was present in 61 patients. The median time to DTU detection was 5.7 months (range, 0-21.3 months). High International Prognostic Index (IPI) score (progression-free survival [PFS], p = 0.001; overall survival [OS], p = 0.008), bulky mass ≥10 cm (PFS, p = 0.001; OS, p = 0.001), bone marrow involvement (PFS, p < 0.001; OS, p = 0.001), and DTU after R-CHOP therapy (PFS, p < 0.001; OS, p = 0.001) were significantly associated with PFS and OS. High IPI score (PFS, p = 0.003; OS, p = 0.014), BM involvement (PFS, p = 0.009; OS, p = 0.039), and DTU after R-CHOP therapy (PFS, p = 0.002; OS, p = 0.002) were independently associated with PFS and OS. DTU after R-CHOP therapy independently predicted favorable outcomes in patients with DLBCL.

Community emergency department utilization following a natural disaster (the Goderich Tornado).

PubMed

Appavoo, Samuel D; Khemlin, Alexander; Appavoo, Donna M; Flynn, Candi J

2016-01-01

On 21 August 2011 an F3 tornado hit the Canadian town of Goderich, Ontario, leaving 40 people injured and one dead. Specific medium-term changes in utilization of health care following a disaster have not been analyzed in medical literature. Documenting the emergency department utilization through this subacute period would be helpful to enable institutions and healthcare practitioners to be better prepared for future events. A medical chart review was conducted at the Alexandra Marine and General Hospital in Goderich. All emergency department visits made during the 30 days after the Tornado in 2011 (intervention group), 30 days prior to the tornado in 2011 (primary control group), and during the similar calendar period of 30 days after the tornado in 2010 (seasonal control group) were reviewed. Medical diagnoses of all patients who presented at the emergency department were collected and compared. Fewer people presented to the emergency department following the tornado than during the control periods, and those who did were significantly older than those who presented in the control periods (p<0.001). A significantly greater number of patients presented with undiagnosed medical problems, many came to refill their medications, and significantly fewer people left the emergency department without being seen (p<0.001). This study identifies the medical conditions that are most likely to be seen in an emergency department following a tornado in a rural Ontario community. This information serves to inform the medical community and other hospitals how to increase their level of preparedness should a comparable disaster occur again in the future.

PARFUME Theory and Model basis Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Darrell L. Knudson; Gregory K Miller; G.K. Miller

2009-09-01

The success of gas reactors depends upon the safety and quality of the coated particle fuel. The fuel performance modeling code PARFUME simulates the mechanical, thermal and physico-chemical behavior of fuel particles during irradiation. This report documents the theory and material properties behind vari¬ous capabilities of the code, which include: 1) various options for calculating CO production and fission product gas release, 2) an analytical solution for stresses in the coating layers that accounts for irradiation-induced creep and swelling of the pyrocarbon layers, 3) a thermal model that calculates a time-dependent temperature profile through a pebble bed sphere or amore » prismatic block core, as well as through the layers of each analyzed particle, 4) simulation of multi-dimensional particle behavior associated with cracking in the IPyC layer, partial debonding of the IPyC from the SiC, particle asphericity, and kernel migration (or amoeba effect), 5) two independent methods for determining particle failure probabilities, 6) a model for calculating release-to-birth (R/B) ratios of gaseous fission products that accounts for particle failures and uranium contamination in the fuel matrix, and 7) the evaluation of an accident condition, where a particle experiences a sudden change in temperature following a period of normal irradiation. The accident condi¬tion entails diffusion of fission products through the particle coating layers and through the fuel matrix to the coolant boundary. This document represents the initial version of the PARFUME Theory and Model Basis Report. More detailed descriptions will be provided in future revisions.« less

Where Do Patients With Cancer in Iowa Receive Radiation Therapy?

PubMed Central

Ward, Marcia M.; Ullrich, Fred; Matthews, Kevin; Rushton, Gerard; Tracy, Roger; Goldstein, Michael A.; Bajorin, Dean F.; Kosty, Michael P.; Bruinooge, Suanna S.; Hanley, Amy; Jacobson, Geraldine M.; Lynch, Charles F.

2014-01-01

Purpose: Multiple studies have shown survival benefits in patients with cancer treated with radiation therapy, but access to treatment facilities has been found to limit its use. This study was undertaken to examine access issues in Iowa and determine a methodology for conducting a similar national analysis. Patients and Methods: All Iowa residents who received radiation therapy regardless of where they were diagnosed or treated were identified through the Iowa Cancer Registry (ICR). Radiation oncologists were identified through the Iowa Physician Information System (IPIS). Radiation facilities were identified through IPIS and classified using the Commission on Cancer accreditation standard. Results: Between 2004 and 2010, 113,885 invasive cancers in 106,603 patients, 28.5% of whom received radiation treatment, were entered in ICR. Mean and median travel times were 25.8 and 20.1 minutes, respectively, to the nearest facility but 42.4 and 29.1 minutes, respectively, to the patient's chosen treatment facility. Multivariable analysis predicting travel time showed significant relationships for disease site, age, residence location, and facility category. Residents of small and isolated rural towns traveled nearly 3× longer than urban residents to receive radiation therapy, as did patients using certain categories of facilities. Conclusion: Half of Iowa patients could reach their nearest facility in 20 minutes, but instead, they traveled 30 minutes on average to receive treatment. The findings identified certain groups of patients with cancer who chose more distant facilities. However, other groups of patients with cancer, namely those residing in rural areas, had less choice, and some had to travel considerably farther to radiation facilities than urban patients. PMID:24443730

The association between short interpregnancy interval and preterm birth in Louisiana: a comparison of methods.

PubMed

Howard, Elizabeth J; Harville, Emily; Kissinger, Patricia; Xiong, Xu

2013-07-01

There is growing interest in the application of propensity scores (PS) in epidemiologic studies, especially within the field of reproductive epidemiology. This retrospective cohort study assesses the impact of a short interpregnancy interval (IPI) on preterm birth and compares the results of the conventional logistic regression analysis with analyses utilizing a PS. The study included 96,378 singleton infants from Louisiana birth certificate data (1995-2007). Five regression models designed for methods comparison are presented. Ten percent (10.17 %) of all births were preterm; 26.83 % of births were from a short IPI. The PS-adjusted model produced a more conservative estimate of the exposure variable compared to the conventional logistic regression method (β-coefficient: 0.21 vs. 0.43), as well as a smaller standard error (0.024 vs. 0.028), odds ratio and 95 % confidence intervals [1.15 (1.09, 1.20) vs. 1.23 (1.17, 1.30)]. The inclusion of more covariate and interaction terms in the PS did not change the estimates of the exposure variable. This analysis indicates that PS-adjusted regression may be appropriate for validation of conventional methods in a large dataset with a fairly common outcome. PS's may be beneficial in producing more precise estimates, especially for models with many confounders and effect modifiers and where conventional adjustment with logistic regression is unsatisfactory. Short intervals between pregnancies are associated with preterm birth in this population, according to either technique. Birth spacing is an issue that women have some control over. Educational interventions, including birth control, should be applied during prenatal visits and following delivery.

Enhancing Heart-Beat-Based Security for mHealth Applications.

PubMed

Seepers, Robert M; Strydis, Christos; Sourdis, Ioannis; De Zeeuw, Chris I

2017-01-01

In heart-beat-based security, a security key is derived from the time difference between consecutive heart beats (the inter-pulse interval, IPI), which may, subsequently, be used to enable secure communication. While heart-beat-based security holds promise in mobile health (mHealth) applications, there currently exists no work that provides a detailed characterization of the delivered security in a real system. In this paper, we evaluate the strength of IPI-based security keys in the context of entity authentication. We investigate several aspects that should be considered in practice, including subjects with reduced heart-rate variability (HRV), different sensor-sampling frequencies, intersensor variability (i.e., how accurate each entity may measure heart beats) as well as average and worst-case-authentication time. Contrary to the current state of the art, our evaluation demonstrates that authentication using multiple, less-entropic keys may actually increase the key strength by reducing the effects of intersensor variability. Moreover, we find that the maximal key strength of a 60-bit key varies between 29.2 bits and only 5.7 bits, depending on the subject's HRV. To improve security, we introduce the inter-multi-pulse interval (ImPI), a novel method of extracting entropy from the heart by considering the time difference between nonconsecutive heart beats. Given the same authentication time, using the ImPI for key generation increases key strength by up to 3.4 × (+19.2 bits) for subjects with limited HRV, at the cost of an extended key-generation time of 4.8 × (+45 s).

Inspiring students through an authentic polar science expedition: the RESEt Project

NASA Astrophysics Data System (ADS)

Cattadori, Matteo

2016-04-01

RESEt (Research and Education Svalbard Experience www.resetsvalbard.it) is an ongoing educational project focusing mainly on polar and climate system topics. It started in 2014 and will end in 2017 with the high school diploma of the 22 students (16 y. o.) making the participant class. This class attend a school (Liceo Filzi, Rovereto, Trento. Italy) with a primary focus on disciplines like philosophy and education, rather then STEM (Science, Technology, Engineering, and Mathematics). Nevertheless their science curricula include climate topics that are rather challenging to grasp and, at the same time, crucial for their scientific citizenship. Some questions arise: How to foster their interest in geosciences topics? How to engage them in authentic scientific knowledge? How to increase their interest in scientific university courses during their post-secondary career? RESEt project will attempt to answer these questions through the development of integrated activities distributed over the last three years of their high school cycle. The most important moment will be an educational scientific expedition at the Svalbard, an archipelago located in the Arctic. The expedition be entirely organized, planned, and directed by students. In Svalbard, students will visit the main scientific facilities devoted to climate studies including those of Italian CNR (National Research Council) and they will perform some environmental measurement using data-loggers. Students are even involved in the fundraising process to raise more than ten thousand Euros needed to for travel expenses. This work is aimed mainly at presenting some of the preliminary data collected during the RESEt project, including the fundraising aspects. The management of the RESEt project strongly relies on the experience and network gained by the abstract author during the participation to the Education and Public Outreach (EPO) program of International Polar Year (IPY) 2007-2009 as well as the support of Polar Educators International (PEI) an association of polar educators and teachers. The formal presentation of the final results achieved will be held during the 3rd edition of the PEI International Workshop that will be organized in Italy in April 2017.

IHY-IPY conference report from Polar Gateways Arctic Circle Sunrise 2008

NASA Astrophysics Data System (ADS)

Cooper, John; Kauristie, Kirsti; Weatherwax, Allan; Thompson, Barbara; Sheehan, Glenn; Smith, Roger; Sandahl, Ingrid

Polar, heliophysical, and planetary science topics related to the International Heliophysical and Polar Years 2007-2009 were addressed during this unique circumpolar conference hosted January 23-29, 2008 at the new Barrow Arctic Research Center of the Barrow Arctic Science Consortium in Barrow, Alaska. Science presentations spanned the solar system from the polar Sun and heliospheric environment to Earth, Moon, Mars, Jupiter, Saturn, the Kuiper Belt, and the solar wind termination shock now crossed by both Voyager spacecraft. Many of the science presentations were made remotely via video conference or teleconference from Sweden, Norway, Russia, Canada, Antarctica, and the United States, spanning up to thirteen time zones (Alaska to Russia) at various times during the conference. U.S. remote contributions came from the University of Alaska at Fairbanks, the University of California at Berkeley, the University of Arizona, NASA Jet Propulsion Laboratory, and NASA Goddard Space Flight Center. Convening during the first week of 2008 Arctic sunrise at Barrow, this conference served as a prelude that year to international Sun-Earth Day celebrations for IHY, while also commemorating Barrow scientific and native cultural support for the first International Polar Year 1882-1883. Extensive educational outreach activities were conducted with the local Barrow and Alaska North Slope communities and through the NASA Digital Learning Network live from the "top of the world" at Barrow. The conference proceedings are Internet accessible via the home page at http://polargateways2008.org/.

Spatial distribution of atmospheric constituents along the Arctic coast of Siberia

NASA Astrophysics Data System (ADS)

Belan, Boris D.; Arshinov, Mikhail Yu.; Belan, Sergey B.; Davydov, Denis K.; Ivlev, Georgii A.; Kozlov, Artem V.; Kozlov, Valerii S.; Paris, Jean-Dniel; Nédélec, Philippe; Panchenko, Mikhail V.; Simonenkov, Denis V.; Tolmachev, Gennadii N.; Fofonov, Alexander V.; Shmargunov, Vladimir P.

2014-05-01

Extensive airborne in-situ measurements of atmospheric trace gas species and aerosols over the Siberian Arctic were carried out in July 2008 in the framework of the YAK-AEROSIB and POLARCAT projects under the International Polar Year (IPY). During the campaign, the Optik-É AN-30 aircraft laboratory was used as a research platform (Antokhin et al., 2012). The measurement campaign consisted of two longitudinal and two latitudinal transects in the troposphere from the ground level to a height of about 7 kilometers. The arctic longitudinal transect extended from 66° 37'23'E to 170° 44'18'E, and the remote continental one - from 129° 46'47'E to 82° 47'25'E. Along the Arctic coast, the sea was ice covered. Measurements showed that variation of CO2 mixing ratio within the lower troposphere (below 3 km) over the Arctic region was small and ranged from 382 to 385 ppm, whereas over the remote continental regions CO2 concentration values were lower and varied over a wider range from 367 to 381 ppm (with minimum over forested areas). So, the conclusion can be drawn that CO2 uptake by Siberian arctic ecosystems is weak. Maximal mixing ratios of CO (≡100 ppb) observed within the lower tropospheric layer over the Arctic were 1.4 times lower than the free tropospheric ones. The vertical ozone distribution obtained during the flights along the Arctic coast showed that ozone was mainly transported from the stratosphere. This work was funded by ANR as a part of POLARCAT France (grant BLAN06-1 137670), by the Norwegian Research Council as part of POLARCAT-Norway, CNRS (France), the French Ministry of Foreign Affairs, CEA (France), Presidium of RAS (Program No. 4), Brunch of Geology, Geophysics and Mining Sciences of RAS (Program No. 5), Interdisciplinary integration projects of Siberian Branch of RAS (No. 35, No. 70, No. 131), Russian Foundation for Basic Research (grants No 14-05-00526, 14-05-00590). Antokhin P.N., Arshinov M.Yu., Belan B.D., Davydov D.K., Zhidovkin E.V., Ivlev G.A., Kozlov A.V., Kozlov V.S., Panchenko M.V., Penner I.E., Pestunov D.A., Simonenkov D.V., Tolmachev G.N., Fofonov A.V., Shamanaev V.S., Shmargunov V.P. 2012. Optik-É AN-30 aircraft laboratory: 20 years of environmental research. Journal of Atmospheric and Oceanic Technology, V.29, No 1, 64-75.

The ipdC, hisC1 and hisC2 genes involved in indole-3-acetic production used as alternative phylogenetic markers in Azospirillum brasilense.

PubMed

Jijón-Moreno, Saúl; Marcos-Jiménez, Cynthia; Pedraza, Raúl O; Ramírez-Mata, Alberto; de Salamone, I García; Fernández-Scavino, Ana; Vásquez-Hernández, Claudia A; Soto-Urzúa, Lucia; Baca, Beatriz E

2015-06-01

Plant growth-promoting bacteria of the genus Azospirillum are present in the rhizosphere and as endophytes of many crops. In this research we studied 40 Azospirillum strains isolated from different plants and geographic regions. They were first characterized by 16S rDNA restriction analysis, and their phylogenetic position was established by sequencing the genes 16S rDNA, ipdC, hisC1, and hisC2. The latter three genes are involved in the indole-3-pyruvic acid (IPyA) biosynthesis pathway of indole-3-acetic acid (IAA). Furthermore, the suitability of the 16S-23S rDNA intergenic spacer sequence (IGS) for the differentiation of closely related Azospirillum taxa and development of PCR protocols allows for specific detection of strains. The IGS-RFLP analysis enabled intraspecies differentiation, particularly of Azospirillum brasilense and Azospirillum lipoferum strains. Results demonstrated that the ipdC, hisC1, and hisC2 genes are highly conserved in all the assessed A. brasilense isolates, suggesting that these genes can be used as an alternative phylogenetic marker. In addition, IAA production determined by HPLC ranged from 0.17 to 98.2 μg mg(-1) protein. Southern hybridization with the A. brasilense ipdC gene probe did not show, a hybridization signal with A. lipoferum, Azospirillum amazonense, Azospirillum halopreferans and Azospirillum irakense genomic DNA. This suggests that these species produce IAA by other pathways. Because IAA is mainly synthesized via the IPyA pathway in A. brasilense strains, a species that is used worldwide in agriculture, the identification of ipdC, hisC1, and hisC2 genes by PCR may be suitable for selecting exploitable strains.

Implications of infiltrating immune cells within bone marrow of patients with diffuse large B-cell lymphoma.

PubMed

Jeong, Juhyeon; Oh, Eun Ji; Yang, Woo Ick; Kim, Soo Jeong; Yoon, Sun Och

2017-06-01

The implications of infiltrating immune cells, especially T cells and macrophages, in the bone marrow (BM) microenvironment of patients with diffuse large B-cell lymphoma (DLBCL) have rarely been studied. We aimed to investigate the significance of infiltrating immune cells in the BM microenvironment as a prognostic factor for DLBCL patients. Using the initial pretreatment BM biopsy obtained from 198 DLBCL patients, we semiquantitatively evaluated CD3+ T cells, CD8+ T cells, and CD163+ macrophages that infiltrate into the paratrabecular and interstitial areas of BM by immunohistochemistry and analyzed their clinicopathological and prognostic implications. Levels of infiltrating CD3+ T cells, CD8+ T cells, and CD163+ macrophages were significantly higher in BM with DLBCL involvement (BMI-positive group) than in that without DLBCL involvement (BMI-negative group). Infiltration of CD8+ T cells significantly increased in cases with advanced Ann Arbor stage, elevated lactate dehydrogenase level, extranodal site involvement ≥2 sites, higher Eastern Cooperative Oncology Group performance status, and higher International Prognostic Index (IPI) risk. High levels of CD3+ T cells were significantly associated with age ≤60, and high levels of CD163+ macrophages were associated with advanced Ann Arbor stage and higher IPI risk. High infiltration of CD8+ T cells was significantly related to inferior overall and recurrence-free survival rate, even in the BMI-negative group. High infiltration of CD8+ T cells within the pretreatment BM was related to poor prognosis, and might be a useful prognostic factor of DLBCL patients. Therefore, evaluation of CD8+ T cells is helpful for predicting prognosis in initial pretreatment BM biopsy of DLBCL patients. Copyright © 2017 Elsevier Inc. All rights reserved.

Data storage and retrieval system abstract

NASA Technical Reports Server (NTRS)

Matheson, Barbara

1992-01-01

The STX mass storage system design is intended for environments requiring high speed access to large volumes of data (terabyte and greater). Prior to commitment to a product design plan, STX conducted an exhaustive study of the commercially available off-the-shelf hardware and software. STX also conducted research into the area of emerging technologies in networks and storage media so that the design could easily accommodate new interfaces and peripherals as they came on the market. All the selected system elements were brought together in a demo suite sponsored jointly by STX and ALLIANT where the system elements were evaluated based on actual operation using a client-server mirror image configuration. Testing was conducted to assess the various component overheads and results were compared against vendor data claims. The resultant system, while adequate to meet our capacity requirements, fell short of transfer speed expectations. A product team lead by STX was assembled and chartered with solving the bottleneck issues. Optimization efforts yielded a 60 percent improvement in throughput performance. The ALLIANT computer platform provided the I/O flexibility needed to accommodate a multitude of peripheral interfaces including the following: up to twelve 25MB/s VME I/O channels; up to five HiPPI I/O full duplex channels; IPI-s, SCSI, SMD, and RAID disk array support; standard networking software support for TCP/IP, NFS, and FTP; open architecture based on standard RISC processors; and V.4/POSIX-based operating system (Concentrix). All components including the software are modular in design and can be reconfigured as needs and system uses change. Users can begin with a small system and add modules as needed in the field. Most add-ons can be accomplished seamlessly without revision, recompilation or re-linking of software.

OCoc- from Ocean Colour to Organic Carbon

NASA Astrophysics Data System (ADS)

Heim, B.; Overduin, P. P.; Schirrmeister, L.; Lantuit, H.; Doerffer, R.

2009-12-01

Enhanced permafrost warming and increased arctic river discharges have heightened concern about the input of terrigenous matter into Arctic coastal waters. The ‘OCoc-from Ocean Colour to Organic Carbon’ project (IPY-project 1176), funded by the German Research Foundation (DFG), is an Ocean Colour study joined with the Arctic Coastal Dynamics ACD network and Arctic Circum-polar Coastal Observatory Network ACCO-Net (IPY-project 90). OCoc uses Ocean Colour satellite data for synoptical monitoring of organic matter fluxes from fluvial and coastal sources. Initial results from German-Russian expeditions at the southeastern Laptev Sea Coast (Arctic Siberia, Russia) in August 2008 and August 2009 are presented. Large parts of this coastal zone are characterized by highly erosive organic-rich material. Ocean Colour MERIS Reduced Resolution (RR)-LIB data of the have been processed towards optical aquatic parameters using Beam-Visat4.2 and the MERIS case2 regional processor for coastal application (C2R). Calculated aquatic parameters are absorption and backscattering coefficients, apparent optical properties such as the first attenuation depth (‘Z90’) and calculated concentrations of chlorophyll, total suspended matter and coloured dissolved organic matter absorption from the water leaving reflectances. Initial comparisons with expedition data (Secchi depths, cDOM) show that the MERIS-C2R optical parameters ’total absorption’ and the first attenuation depth, ’Z90’, seem adequately to represent true conditions. High attenuation values in the spectral blue wavelength range may serve as tracer for the organic-rich terrigenous input. The synoptic information of Ocean Colour products will provide valuable spatial and dynamical information on the Organic Carbon and sediment fluxes from the Siberian permafrost coast.

Electric cell-substrate impedance sensing (ECIS) based real-time measurement of titer dependent cytotoxicity induced by adenoviral vectors in an IPI-2I cell culture model.

PubMed

Müller, Jakob; Thirion, Christian; Pfaffl, Michael W

2011-01-15

Recombinant viral vectors are widespread tools for transfer of genetic material in various modern biotechnological applications like for example RNA interference (RNAi). However, an accurate and reproducible titer assignment represents the basic step for most downstream applications regarding a precise multiplicity of infection (MOI) adjustment. As necessary scaffold for the studies described in this work we introduce a quantitative real-time PCR (qPCR) based approach for viral particle measurement. Still an implicated problem concerning physiological effects is that the appliance of viral vectors is often attended by toxic effects on the individual target. To determine the critical viral dose leading to cell death we developed an electric cell-substrate impedance sensing (ECIS) based assay. With ECIS technology the impedance change of a current flow through the cell culture medium in an array plate is measured in a non-invasive manner, visualizing effects like cell attachment, cell-cell contacts or proliferation. Here we describe the potential of this online measurement technique in an in vitro model using the porcine ileal epithelial cell line IPI-2I in combination with an adenoviral transfection vector (Ad5-derivate). This approach shows a clear dose-depending toxic effect, as the amount of applied virus highly correlates (p<0.001) with the level of cell death. Thus this assay offers the possibility to discriminate the minimal non-toxic dose of the individual transfection method. In addition this work suggests that the ECIS-device bears the feasibility to transfer this assay to multiple other cytotoxicological questions. Copyright © 2010 Elsevier B.V. All rights reserved.

Implementation of a chemical background method (OH-CHEM) for measurements of OH using the Leeds FAGE instrument: Characterisation and observations from a coastal location

NASA Astrophysics Data System (ADS)

Woodward-Massey, R.; Cryer, D. R.; Whalley, L. K.; Ingham, T.; Seakins, P. W.; Heard, D. E.; Stimpson, L. M.

2015-12-01

The removal of pollutants and greenhouse gases in the troposphere is dominated by reactions with the hydroxyl radical (OH), which is closely coupled to the hydroperoxy radical (HO2). Comparisons of the levels of OH and HO2 observed during field campaigns to the results of detailed chemical box models serve as a vital tool to assess our understanding of the underlying chemical mechanisms involved in tropospheric oxidation. Recent measurements of OH and HO2 radicals are significantly higher than those predicted by models for some instruments measuring in certain environments, especially those influenced by high emissions of biogenic compounds such as isoprene, prompting intense laboratory research to account for such discrepancies. While current chemical mechanisms are likely incomplete, it is also possible that, at least in part, these elevated radical observations have been influenced by instrumental biases from interfering species. Recent studies have suggested that fluorescence assay by gas expansion (FAGE) instruments may be susceptible to an unknown interference in the measurement of OH. This hypothesis can be tested through the implementation of an alternative method to determine the OH background signal, whereby OH is removed by the addition of a chemical scavenger prior to sampling by FAGE. The Leeds FAGE instrument was modified to facilitate this method by the construction of an inlet pre-injector (IPI), where OH is removed through reaction with propane. The modified Leeds FAGE instrument was deployed at a coastal location in southeast England during summer 2015 as part of the ICOZA (Integrated Chemistry of OZone in the Atmosphere) project. Measurements of OH made using both background methods will be presented, alongside results from laboratory characterisation experiments and details of the IPI design.

Data storage and retrieval system abstract

NASA Astrophysics Data System (ADS)

Matheson, Barbara

1992-09-01

The STX mass storage system design is intended for environments requiring high speed access to large volumes of data (terabyte and greater). Prior to commitment to a product design plan, STX conducted an exhaustive study of the commercially available off-the-shelf hardware and software. STX also conducted research into the area of emerging technologies in networks and storage media so that the design could easily accommodate new interfaces and peripherals as they came on the market. All the selected system elements were brought together in a demo suite sponsored jointly by STX and ALLIANT where the system elements were evaluated based on actual operation using a client-server mirror image configuration. Testing was conducted to assess the various component overheads and results were compared against vendor data claims. The resultant system, while adequate to meet our capacity requirements, fell short of transfer speed expectations. A product team lead by STX was assembled and chartered with solving the bottleneck issues. Optimization efforts yielded a 60 percent improvement in throughput performance. The ALLIANT computer platform provided the I/O flexibility needed to accommodate a multitude of peripheral interfaces including the following: up to twelve 25MB/s VME I/O channels; up to five HiPPI I/O full duplex channels; IPI-s, SCSI, SMD, and RAID disk array support; standard networking software support for TCP/IP, NFS, and FTP; open architecture based on standard RISC processors; and V.4/POSIX-based operating system (Concentrix). All components including the software are modular in design and can be reconfigured as needs and system uses change. Users can begin with a small system and add modules as needed in the field. Most add-ons can be accomplished seamlessly without revision, recompilation or re-linking of software.

The recognition and evaluation of patterns of compensatory injury in patients with mechanical hip pain.

PubMed

Hammoud, Sommer; Bedi, Asheesh; Voos, James E; Mauro, Craig S; Kelly, Bryan T

2014-03-01

In active individuals with femoroacetabular impingement (FAI), the resultant reduction in functional range of motion leads to high impaction loads at terminal ranges. These increased forces result in compensatory effects on bony and soft tissue structures within the hip joint and hemipelvis. An algorithm is useful in evaluating athletes with pre-arthritic, mechanical hip pain and associated compensatory disorders. A literature search was performed by a review of PubMed articles published from 1976 to 2013. Level 4. Increased stresses across the bony hemipelvis result when athletes with FAI attempt to achieve supraphysiologic, terminal ranges of motion (ROM) through the hip joint required for athletic competition. This can manifest as pain within the pubic joint (osteitis pubis), sacroiliac joint, and lumbosacral spine. Subclinical posterior hip instability may result when attempts to increase hip flexion and internal rotation are not compensated for by increased motion through the hemipelvis. Prominence of the anterior inferior iliac spine (AIIS) at the level of the acetabular rim can result in impingement of the anterior hip joint capsule or iliocapsularis muscle origin against the femoral head-neck junction, resulting in a distinct form of mechanical hip impingement (AIIS subspine impingement). Iliopsoas impingement (IPI) has also been described as an etiology for anterior hip pain. IPI results in a typical 3-o'clock labral tear as well as an inflamed capsule in close proximity to the overlying iliopsoas tendon. Injury in athletic pubalgia occurs during high-energy twisting activities in which abnormal hip ROM and resultant pelvic motion lead to shearing across the pubic symphysis. Failure to recognize and address concomitant compensatory injury patterns associated with intra-articular hip pathology can result in significant disability and persistent symptoms in athletes with pre-arthritic, mechanical hip pain. B.

Relationship between negative affect and smoking topography in heavy drinking smokers.

PubMed

Green, ReJoyce; Bujarski, Spencer; Roche, Daniel J O; Ray, Lara A

2016-10-01

Heavy drinking smokers represent a sizeable subgroup of smokers for whom nicotine deprivation and alcohol use increases the urge to smoke in the laboratory and predicts lapses during smoking cessation. The manner in which individuals smoke a cigarette (i.e. smoking topography) provides a reliable index of smoking intensity and reinforcement, yet the effects of affect on smoking topography have not been thoroughly examined in heavy drinking smokers. The current study examined how affect and nicotine deprivation predict smoking behavior as participants (N=27) smoked one cigarette using a smoking topography device after 12-h of nicotine abstinence and after a priming dose of alcohol (target BrAC=0.06g/dl). Primary smoking topography measures were puff volume, velocity, duration, and inter-puff interval (IPI). The effect of nicotine deprivation was measured by the Minnesota Nicotine Withdrawal Scale (MNWS) and the Profile of Mood States (POMS). Measures were obtained at baseline (i.e. 12-h of nicotine abstinence and pre-alcohol) and 30-minutes after alcohol administration (i.e. peak BrAC). Results revealed post-priming negative affect significantly moderated the trajectories of puff volume, puff duration and IPI (p's<0.05) over the course of the cigarette, such that those with greater negative affect had flatter slopes for volume and duration and increasingly infrequent puffs. Our results suggest that baseline and post-priming negative affect following nicotine deprivation alters smoking patterns and increases nicotine exposure throughout a single cigarette. Future studies need to examine differential amounts of nicotine deprivation on response to alcohol and smoking in heavy drinking smokers. Copyright © 2016 Elsevier Ltd. All rights reserved.

At the Frontier; RXLR Effectors Crossing the Phytophthora-Host Interface.

PubMed

Bouwmeester, Klaas; Meijer, Harold J G; Govers, Francine

2011-01-01

Plants are constantly beset by pathogenic organisms. To successfully infect their hosts, plant pathogens secrete effector proteins, many of which are translocated to the inside of the host cell where they manipulate normal physiological processes and undermine host defense. The way by which effectors cross the frontier to reach the inside of the host cell varies among different classes of pathogens. For oomycete plant pathogens - like the potato late blight pathogen Phytophthora infestans - it has been shown that effector translocation to the host cell cytoplasm is dependent on conserved amino acid motifs that are present in the N-terminal part of effector proteins. One of these motifs, known as the RXLR motif, has a strong resemblance with a host translocation motif found in effectors secreted by Plasmodium species. These malaria parasites, that reside inside specialized vacuoles in red blood cells, make use of a specific protein translocation complex to export effectors from the vacuole into the red blood cell. Whether or not also oomycete RXLR effectors require a translocation complex to cross the frontier is still under investigation. For one P. infestans RXLR effector named IPI-O we have found a potential host target that could play a role in establishing the first contact between this effector and the host cell. This membrane spanning lectin receptor kinase, LecRK-I.9, interacts with IPI-O via the tripeptide RGD that overlaps with the RXLR motif. In animals, RGD is a well-known cell adhesion motif; it binds to integrins, which are membrane receptors that regulate many cellular processes and which can be hijacked by pathogens for either effector translocation or pathogen entry into host cells.

Detection and analysis of particles with failed SiC in AGR-1 fuel compacts

DOE PAGES

Hunn, John D.; Baldwin, Charles A.; Gerczak, Tyler J.; ...

2016-04-06

As the primary barrier to release of radioactive isotopes emitted from the fuel kernel, retention performance of the SiC layer in tristructural isotropic (TRISO) coated particles is critical to the overall safety of reactors that utilize this fuel design. Most isotopes are well-retained by intact SiC coatings, so pathways through this layer due to cracking, structural defects, or chemical attack can significantly contribute to radioisotope release. In the US TRISO fuel development effort, release of 134Cs and 137Cs are used to detect SiC failure during fuel compact irradiation and safety testing because the amount of cesium released by a compactmore » containing one particle with failed SiC is typically ten or more times higher than that released by compacts without failed SiC. Compacts with particles that released cesium during irradiation testing or post-irradiation safety testing at 1600–1800 °C were identified, and individual particles with abnormally low cesium retention were sorted out with the Oak Ridge National Laboratory (ORNL) Irradiated Microsphere Gamma Analyzer (IMGA). X-ray tomography was used for three-dimensional imaging of the internal coating structure to locate low-density pathways through the SiC layer and guide subsequent materialography by optical and scanning electron microscopy. In addition, all three cesium-releasing particles recovered from as-irradiated compacts showed a region where the inner pyrocarbon (IPyC) had cracked due to radiation-induced dimensional changes in the shrinking buffer and the exposed SiC had experienced concentrated attack by palladium; SiC failures observed in particles subjected to safety testing were related to either fabrication defects or showed extensive Pd corrosion through the SiC where it had been exposed by similar IPyC cracking.« less

Reaching Across the Hemispheres with Science, Language, Arts and Technology

NASA Astrophysics Data System (ADS)

Sparrow, E. B.; Zicus, S.; Miller, A.; Baird, A.; Page, G.

2009-12-01

Twelve Alaskan elementary and middle school classes (grades 3-8) partnered with twelve Australian middle school classes, with each pair using web-based strategies to develop a collaborative ice-mystery fictional book incorporating authentic polar science. Three professional development workshops were held, bringing together educators and polar scientists in two IPY education outreach projects. The Alaska workshop provided an opportunity to bring together the North American teachers for lessons on arctic and antarctic science and an earth system science program Seasons and Biomes measurement protocols, as well as methods in collaborative e-writing and art in Ice e-Mysteries: Global Student Polar e-books project. Teachers worked with University of Alaska Fairbanks (UAF) and Australian scientists to become familiar with Arctic science research, science artifacts and resources available at UAF and the University of Alaska Museum of the North. In Australia, teachers received a similar project training through the Tasmania Museum and Art Gallery (TMAG) Center for Learning and Discovery on Antarctic science and the University of Tasmania. The long-distance collaboration was accomplished through Skype, emails and a TMAG supported website. A year later, Northern Hemisphere and Southern Hemisphere teacher partners met in a joint workshop in Tasmania, to share their experiences, do project assessments and propose activities for future collaborations. The Australian teachers received training on Seasons and Biomes scientific measurements and the Alaskan teachers, on Tasmanian vegetation, fauna and indigenous culture, Antarctic and Southern ocean studies. This innovative project produced twelve e-polar books written and illustrated by students; heightened scientific literacy about the polar regions and the earth system; increased awareness of the environment and indigenous cultures; stronger connections to the scientific community; and lasting friendships. It also resulted in an effective integration of science across the curriculum. The teacher partners are continuing their collaboration across the hemispheres.

Clinical Research on the Comprehensive Curative Effect of Acupuncture and Traditional Chinese Medicine for Pelvic Inflammatory Sequelae.

PubMed

Mao, Penyuan; Liu, Shujie; Xue, Jianguo; Wu, Yuejun; Wang, Changqing

2018-05-08

BACKGROUND This randomized, controlled trial was designed to assess whether acupuncture plus an oral administration of Chinese herbal medicine provides greater relief of symptoms than oral administration of Chinese herbal medicine alone for treatment of pelvic inflammatory sequelae. MATERIAL AND METHODS Sixty-two patients ages 22 to 45 years with pelvic inflammatory sequelae were randomly assigned into one of 2 groups: an herbal group (n=30) and an herbal with acupuncture group (n=32). Both groups were treated for 3 courses of 3 months each. RESULTS Significant improvement of clinical symptoms and signs of pelvic inflammatory sequelae occurred in both treatment groups. The total effective rate for the herbal group was 83.33%, and for the herbal with acupuncture group it was 100% ([i]P[/i]=0.354 for difference between groups). During treatment, 5 patients had adverse reactions of nausea, loss of appetite, and diarrhea. After adjustment of the herb prescription, all adverse reactions disappeared. CONCLUSIONS Our results highlight the benefit of oral administration of Chinese herbal medicine along with acupuncture; this had a greater clinical curative effect rate than oral administration of Chinese herbal medicine alone when treating pelvic inflammatory sequelae.

A PDA study management tool (SMT) utilizing wireless broadband and full DICOM viewing capability

NASA Astrophysics Data System (ADS)

Documet, Jorge; Liu, Brent; Zhou, Zheng; Huang, H. K.; Documet, Luis

2007-03-01

During the last 4 years IPI (Image Processing and Informatics) Laboratory has been developing a web-based Study Management Tool (SMT) application that allows Radiologists, Film librarians and PACS-related (Picture Archiving and Communication System) users to dynamically and remotely perform Query/Retrieve operations in a PACS network. The users utilizing a regular PDA (Personal Digital Assistant) can remotely query a PACS archive to distribute any study to an existing DICOM (Digital Imaging and Communications in Medicine) node. This application which has proven to be convenient to manage the Study Workflow [1, 2] has been extended to include a DICOM viewing capability in the PDA. With this new feature, users can take a quick view of DICOM images providing them mobility and convenience at the same time. In addition, we are extending this application to Metropolitan-Area Wireless Broadband Networks. This feature requires Smart Phones that are capable of working as a PDA and have access to Broadband Wireless Services. With the extended application to wireless broadband technology and the preview of DICOM images, the Study Management Tool becomes an even more powerful tool for clinical workflow management.

Community Needs Assessment and Portal Prototype Development for an Arctic Spatial Data Infrastructure (ASDI)

NASA Astrophysics Data System (ADS)

Wiggins, H. V.; Warnick, W. K.; Hempel, L. C.; Henk, J.; Sorensen, M.; Tweedie, C. E.; Gaylord, A. G.

2007-12-01

As the creation and use of geospatial data in research, management, logistics, and education applications has proliferated, there is now a tremendous potential for advancing science through a variety of cyber-infrastructure applications, including Spatial Data Infrastructure (SDI) and related technologies. SDIs provide a necessary and common framework of standards, securities, policies, procedures, and technology to support the effective acquisition, coordination, dissemination and use of geospatial data by multiple and distributed stakeholder and user groups. Despite the numerous research activities in the Arctic, there is no established SDI and, because of this lack of a coordinated infrastructure, there is inefficiency, duplication of effort, and reduced data quality and search ability of arctic geospatial data. The urgency for establishing this framework is significant considering the myriad of data that is being collected in celebration of the International Polar Year (IPY) in 2007-2008 and the current international momentum for an improved and integrated circum-arctic terrestrial-marine-atmospheric environmental observatories network. The key objective of this project is to lay the foundation for full implementation of an Arctic Spatial Data Infrastructure (ASDI) through an assessment of community needs, readiness, and resources and through the development of a prototype web-mapping portal.

Prognostic Significance of Blood Transfusion in Elderly Patients with Primary Diffuse Large B-Cell Lymphoma

PubMed Central

Fan, Liping; Fu, Danhui; Hong, Jinquan; He, Wenqian; Zeng, Feng; Lin, Qiuyan; Xie, Qianling

2018-01-01

The current study sought to evaluate whether blood transfusions affect survival of elderly patients with primary diffuse large B-cell lymphoma (DLBCL). A total of 104 patients aged 60 years and over were enrolled and divided into two groups: 24 patients who received transfusions and 80 patients who did not. Statistical analyses showed significant differences in LDH levels, platelet (Plt) counts, and hemoglobin (Hb) and albumin (Alb) levels between the two groups. Univariate analyses showed that LDH level ≥ 245 IU/L, cell of origin (germinal center/nongerminal center), and blood transfusion were associated with both overall survival (OS) and progression-free survival (PFS). Higher IPI (3–5), Alb level < 35 g/L, and rituximab usage were associated with OS. Appearance of B symptoms was associated with PFS. Multivariate analyses showed that cell of origin and rituximab usage were independent factors for OS and LDH level was an independent factor for PFS. Blood transfusion was an independent factor for PFS, but not for OS. Our preliminary results suggested that elderly patients with primary DLBCL may benefit from a restrictive blood transfusion strategy. PMID:29750167

Where are they now? - A case study of the impact of international travel support for early career Arctic researchers

NASA Astrophysics Data System (ADS)

Majaneva, Sanna; Hamon, Gwénaëlle; Fugmann, Gerlis; Lisowska, Maja; Baeseman, Jenny

2016-09-01

Supporting and training the next generation of researchers is crucial to continuous knowledge and leadership in Arctic research. An increasing number of Arctic organizations have developed initiatives to provide travel support for Early Career Researchers (ECRs) to participate in workshops, conferences and meetings and to network with internationally renowned scientific leaders. However, there has been little evaluation of the effectiveness of these initiatives. As a contribution to the 3rd International Conference on Arctic Research Planning, a study was conducted to analyze the career paths of ECRs who received travel funding from the International Arctic Science Committee between the start of the International Polar Year (2007-2008) and 2013. Two surveys were used: one sent to ECRs who received IASC travel support and one as a specific event study to those unsuccessfully applied for IASC travel support to the IPY 2010 Conference. The results of the surveys indicate that travel support was beneficial to both the research and careers of the respondents, especially if the ECR was engaged with a task or responsibility at the event. Survey responses also included suggestions on how funds could be better used to support the next generation of Arctic researchers.

Processes Affecting the Annual Surface Energy Budget at High-Latitude Terrestrial Sites

NASA Astrophysics Data System (ADS)

Persson, P. O. G.; Stone, R. S.; Grachev, A.; Matrosova, L.

2012-04-01

Instrumentation at four Study of Environmental Arctic Change (SEARCH) sites (Barrow, Eureka, Alert, and Tiksi) have been enhanced in the past 6 years, including during the 2007-2008 IPY. Data from these sites are used to investigate the annual cycle of the surface energy budget (SEB), its coupling to atmospheric processes, and for Alert, its interannual variability. The comprehensive data sets are useful for showing interactions between the atmosphere, surface, and soil at high temporal resolution throughout the annual cycle. Processes that govern the SEB variability at each site are identified, and their impacts on the SEB are quantified. For example, mesoscale modulation of the SEB caused by forcing from the local terrain (downslope wind events) and coastlines (sea and land breezes) are significant at Alert and Eureka, with these processes affecting both radiative, turbulent, and ground heat flux terms in the SEB. Sub-seasonal and interannual variations in atmospheric processes and SEB impact soil thermal structures, such as the depth and timing of the summer active layer. These analyses provide an improved understanding of the processes producing changes in surface and soil temperature, linking them through the SEB as affected by atmospheric processes.

Technology Insertion (TI)/Industrial Process Improvement (IPI) Task Order Number 15, Data Base Documentation Book SA-ALC/MAE & MAT

DTIC Science & Technology

1990-12-14

r . ,,,’ , ,.r ,-z /Ar A i-, ’- -. q <-->- as 7/ 4, ’C ’ 4’ / de /- --, AI c " (/’r)i -l 74 7 C/L CAe 71C, eX X-- r , ’Ie? 74-4 c- 7,’/,, , /’ 74 V1;he...GLASSES SAFETY GOGGLES CHEMICAL SPLASH GOGGLES &rFACE SHIELD RESPIRATOR ORGANIC VAPOR SPRAY PAINT METAL FUME I TOXIC ,._ ____r _ _ _ OTHER (Speci’y...SAFETY GOGGLES CHEMICAL SPLASH GOGGLES - , FACE SHIELD RESPIRATOR ORGANIC VAPOR SPRAY PAINT METAL FUME ’ TOXIC DUST OTHER (Specify) 23. EMERGENCY

U. S. Naval Forces, Vietnam Monthly Historical Supplement for April 1966

DTIC Science & Technology

1966-05-27

direction *: DTIC SELECTEB^ JAN 2 4 «66 11 < OPV o2 . K JL,.(.:’.IPI?> • UNCLASSIFIED ■f r’ Best Available Copy - ’ DHCtÄS«^ ’ \\ mf, i...8217 ■ • UNCUSSIQED • • i ■ « , •■.•••«• •• ÜNClÄSSIflED ■** . • H? [^O r>it*fx’ KVliVL 1966 PAGfi KAVFOJY ytstabliahment of U.S. K &TaX Force...for K /.CVj and Coraander U.S. tlaval Forces« PhlUpplnos vao navy area coordina* tion authority» CoranAndlng Qenoral III VAT*» »any function» enco

[Comparative study on the efficacy of Hyper CVAD/MA regimen and CHOP or CHOP like regimen in the treatment of primary peripheral T cell lymphoma].

PubMed

Wang, Jin; Gao, Lei; Qiu, Huiying; Zhang, Weiping; Yang, Jianmin; Song, Xianmin; Lyu, Shuqing; Chen, Jie; Wang, Jianmin

2014-10-01

To evaluate the curative efficacy and safety of two regimens, Hyper CVAD/MA and CHOP/CHOP, in the treatment of primary peripheral T cell lymphoma (PTCL). The clinical data of 80 primary PTCL patients were retrospectively analyzed, and the efficacy and safety of the two regimens, Hyper CVAD/MA and CHOP/CHOP, were evaluated. Of 80 patients with primary PTCL, 23 were treated with Hyper CVAD/MA regimen (HM group, experimental group) and 57 with CHOP or CHOP-like regimen (CC group, control group). The differences between overall response rate (ORR) among HM group and CC group (78.3% vs 54.4%, P = 0.047), ORR in patients with IPI score of 0-2 (86.7% vs 55.2%, P = 0.037), courses of chemotherapy to achieve remission (4 vs 6, P = 0.004), median progression-free survival (PFS) time (24 months vs 12 months, P = 0.039) and 1- year PFS rate (82.6% against 45.6%, P = 0.006) were statistically significant. The relapse rates were similar between 2 groups (50.0% vs 54.8%, P = 0.744). The 2-year and 3-year progression-free survivals and 3 year overall survival were not significantly different (P > 0.05). Patients in Hyper CVAD/MA group are more susceptible to neutropenia (<1.5 × 10⁹/L) (73.9% vs 38.6%, P=0.004). The curative effect of Hyper CVAD/MA regimen as induction therapy in treatment of PTCL patients except ALK positive PTCL patients was better than that of CHOP/CHOP-like regimen.

HLA-G and MHC Class II Protein Expression in Diffuse Large B-Cell Lymphoma.

PubMed

Jesionek-Kupnicka, Dorota; Bojo, Marcin; Prochorec-Sobieszek, Monika; Szumera-Ciećkiewicz, Anna; Jabłońska, Joanna; Kalinka-Warzocha, Ewa; Kordek, Radzisław; Młynarski, Wojciech; Robak, Tadeusz; Warzocha, Krzysztof; Lech-Maranda, Ewa

2016-06-01

The expression of human leukocyte antigen-G (HLA-G) and HLA class II protein was studied by immunohistochemical staining of lymph nodes from 148 patients with diffuse large B-cell lymphoma (DLBCL) and related to the clinical course of the disease. Negative HLA-G expression was associated with a lower probability of achieving a complete remission (p = 0.04). Patients with negative HLA-G expression tended towards a lower 3-year overall survival (OS) rate compared to those with positive expression of HLA-G (p = 0.08). When restricting the analysis to patients receiving chemotherapy with rituximab, the estimated 3-year OS rate of patients with positive HLA-G expression was 73.3 % compared with 47.5 % (p = 0.03) in those with negative expression. Patients with negative HLA class II expression presented a lower 3-year OS rate compared to subjects with positive expression (p = 0.04). The loss of HLA class II expression (p = 0.05) and belonging to the intermediate high/high IPI risk group (p = 0.001) independently increased the risk of death. HLA class II expression also retained its prognostic value in patients receiving rituximab; the 3-year OS rate was 65.3 % in patients with positive HLA class II expression versus 29.6 % (p = 0.04) in subjects that had loss of HLA class II expression. To our knowledge, for the first time, the expression of HLA-G protein in DLBCL and its association with the clinical course of the disease was demonstrated. Moreover, the link between losing HLA class II protein expression and poor survival of patients treated with immunochemotherapy was confirmed.

Red blood cell distribution width as a predictor of survival in nasal-type, extranodal natural killer/T-cell lymphoma

PubMed Central

He, Qiao; Cai, Shaolei; Li, Shi; Zeng, Jian; Zhang, Qing; Gao, Yu; Yu, Sisi

2017-01-01

We retrospectively enrolled 191 nasal-type, extranodal natural killer/T-cell lymphoma (ENKTL) patients newly diagnosed from 2008 to 2016 at the Sichuan Cancer Hospital, in order to evaluate the relationship between disease outcomes, demographic and clinical factors, and red blood cell distribution width (RDW). C-index, fisher's exact test, univariate analysis, and cox regression analysis were applied. The median age of patients was 44 years and 134 (70%) were men. The cutoff of RDW was 46.2 fL determined by Cutoff Finder. Patients with RDW≤46.2 fL had significantly better progression-free survival (PFS) (3-year PFS, 80.4% vs. 63.1%; P=0.01) and overall survival (OS) (3-year OS, 83.2% vs. 65.5%; P=0.004) than those with RDW>46.2 fL. Multivariate analysis demonstrated that elevated RDW is an independent adverse predictor of OS (P=0.021, HR=2.04). RDW is an independent predictor of survival outcomes in ENKTL, which we found to be superior to both the prognostic index of natural killer lymphoma (PINK) and the Korean Prognostic Index (KPI) in discriminating patients with different outcomes in low-risk and high-risk groups (all P < 0.05). The new models combining RDW with the International Prognostic Index (IPI), KPI, and PINK showed more powerful prognostic value than corresponding original models. RDW represents an easily available and inexpensive marker for risk stratification in patients with ENKTL treated with radiotherapy-based treatment. Further prospective studies are warranted to confirm the prognostic value of RDW in ENKTL. PMID:29190934

Red blood cell distribution width as a predictor of survival in nasal-type, extranodal natural killer/T-cell lymphoma.

PubMed

Luo, Huaichao; Quan, Xiaoying; Song, Xiao-Yu; Zhang, Li; Yin, Yilin; He, Qiao; Cai, Shaolei; Li, Shi; Zeng, Jian; Zhang, Qing; Gao, Yu; Yu, Sisi

2017-11-03

We retrospectively enrolled 191 nasal-type, extranodal natural killer/T-cell lymphoma (ENKTL) patients newly diagnosed from 2008 to 2016 at the Sichuan Cancer Hospital, in order to evaluate the relationship between disease outcomes, demographic and clinical factors, and red blood cell distribution width (RDW). C-index, fisher's exact test, univariate analysis, and cox regression analysis were applied. The median age of patients was 44 years and 134 (70%) were men. The cutoff of RDW was 46.2 fL determined by Cutoff Finder. Patients with RDW≤46.2 fL had significantly better progression-free survival (PFS) (3-year PFS, 80.4% vs. 63.1%; P =0.01) and overall survival (OS) (3-year OS, 83.2% vs. 65.5%; P =0.004) than those with RDW>46.2 fL. Multivariate analysis demonstrated that elevated RDW is an independent adverse predictor of OS ( P =0.021, HR=2.04). RDW is an independent predictor of survival outcomes in ENKTL, which we found to be superior to both the prognostic index of natural killer lymphoma (PINK) and the Korean Prognostic Index (KPI) in discriminating patients with different outcomes in low-risk and high-risk groups (all P < 0.05). The new models combining RDW with the International Prognostic Index (IPI), KPI, and PINK showed more powerful prognostic value than corresponding original models. RDW represents an easily available and inexpensive marker for risk stratification in patients with ENKTL treated with radiotherapy-based treatment. Further prospective studies are warranted to confirm the prognostic value of RDW in ENKTL.

Conventional chemotherapy (CHOEP-14) with rituximab or high-dose chemotherapy (MegaCHOEP) with rituximab for young, high-risk patients with aggressive B-cell lymphoma: an open-label, randomised, phase 3 trial (DSHNHL 2002-1).

PubMed

Schmitz, Norbert; Nickelsen, Maike; Ziepert, Marita; Haenel, Mathias; Borchmann, Peter; Schmidt, Christian; Viardot, Andreas; Bentz, Martin; Peter, Norma; Ehninger, Gerhard; Doelken, Gottfried; Ruebe, Christian; Truemper, Lorenz; Rosenwald, Andreas; Pfreundschuh, Michael; Loeffler, Markus; Glass, Bertram

2012-12-01

High-dose therapy (HDT) followed by transplantation of autologous haemopoietic stem cells is frequently done as part of first-line therapy in young patients with high-risk aggressive B-cell lymphoma. We investigated whether HDT with cytotoxic agents identical to those used for conventional therapy followed by autologous stem-cell transplantation (ASCT) improved survival outcome compared with conventional chemotherapy when rituximab was added to both modalities. We did an open-label, randomised trial comparing conventional chemotherapy (cyclophosphamide, doxorubicin, vincristine, etoposide, prednisone) and rituximab (R-CHOEP-14) with dose-escalated sequential HDT and rituximab (R-MegaCHOEP) followed by repetitive ASCT in high-risk (age-adjusted International Prognostic Index [IPI] 2 or 3) patients aged 18-60 years with aggressive B-cell lymphoma. Eligible patients received radiotherapy for bulky, extranodal disease, or both. Randomisation (1:1) used the Pocock minimisation algorithm; patients were stratified by age-adjusted IPI factors, bulky disease, and centre. The primary endpoint was event-free survival. All analyses were done on the intention-to-treat population. This trial is registered with ClinicalTrials.gov, number NCT00129090. 136 patients were randomly assigned to R-CHOEP-14 and 139 to R-MegaCHOEP. 130 patients in the R-CHOEP-14 group and 132 in the R-MegaCHOEP group were included in the intention-to-treat population. After a median of 42 months (IQR 29-59), 3-year event-free survival was 69·5% (95% CI 61·3-77·7) in the R-CHOEP-14 group and 61·4% (52·8-70·0) in the R-MegaCHOEP group (p=0·14; hazard ratio 1·3, 95% CI 0·9-2·0). All 128 evaluable patients treated with R-MegaCHOEP had grade 4 leucopenia, as did 48 (58·5%) of 82 patients with documented blood counts in the R-CHOEP-14 group. All 128 evaluable patients in the R-MegaCHOEP group had grade 3-4 thrombocytopenia, as did 26 (33·8%) of 77 patients in the R-CHOEP-14 group with documented blood counts. The most important non-haematological grade 3 or 4 adverse event was infection, which occurred in 96 (75·0%) of 128 patients treated with R-MegaCHOEP and in 40 (31·3%) of 128 patients treated with R-CHOEP-14. In young patients with high-risk aggressive B-cell lymphoma, R-MegaCHOEP was not superior to conventional R-CHOEP therapy and was associated with significantly more toxic effects. R-CHOEP-14 with or without radiotherapy remains a treatment option for these patients, with encouraging efficacy. Deutsche Krebshilfe. Copyright © 2012 Elsevier Ltd. All rights reserved.

B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma.

PubMed

Snuderl, Matija; Kolman, Olga K; Chen, Yi-Bin; Hsu, Jessie J; Ackerman, Adam M; Dal Cin, Paola; Ferry, Judith A; Harris, Nancy Lee; Hasserjian, Robert P; Zukerberg, Lawrence R; Abramson, Jeremy S; Hochberg, Ephraim P; Lee, Hang; Lee, Alfred I; Toomey, Christiana E; Sohani, Aliyah R

2010-03-01

B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements, also known as "double-hit" lymphomas (DHL), are rare neoplasms characterized by highly aggressive clinical behavior, complex karyotypes, and a spectrum of pathologic features overlapping with Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL) and B-lymphoblastic lymphoma/leukemia (B-LBL). The clinical and pathologic spectrum of this rare entity, including comparison to other high-grade B-cell neoplasms, has not been well defined. We conducted a retrospective analysis of clinical and pathologic features of 20 cases of DHL seen at our institution during a 5-year period. In addition, we carried out case-control comparisons of DHL with BL and International Prognostic Index (IPI)-matched DLBCL. The 11 men and 9 women had a median age of 63.5 years (range 32 to 91). Six patients had a history of grade 1 to 2 follicular lymphoma; review of the prior biopsy specimens in 2 of 5 cases revealed blastoid morphology. Eighteen patients had Ann Arbor stage 3 or 4 disease and all had elevated serum lactate dehydrogenase (LDH) levels at presentation. Extranodal disease was present in 17/20 (85%), bone marrow involvement in 10/17 (59%) and central nervous system (CNS) disease in 5/11 (45%). Nineteen patients were treated with combination chemotherapy, of whom 18 received rituximab and 14 received CNS-directed therapy. Fourteen patients (70%) died within 8 months of diagnosis. Median overall survival in the DHL group (4.5 mo) was inferior to both BL (P=0.002) and IPI-matched DLBCL (P=0.04) control patients. Twelve DHL cases (60%) were classified as B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and BL, 7 cases (35%) as DLBCL, not otherwise specified, and 1 case as B-LBL. Distinguishing features from BL included expression of Bcl2 (P<0.0001), Mum1/IRF4 (P=0.006), Ki-67 <95% (P<0.0001), and absence of EBV-EBER (P=0.006). DHL commonly contained the t(8;22) rather than the t(8;14) seen in most BL controls (P=0.001), and exhibited a higher number of chromosomal aberrations (P=0.0009). DHL is a high-grade B-cell neoplasm with a poor prognosis, resistance to multiagent chemotherapy, and clinical and pathologic features distinct from other high-grade B-cell neoplasms. Familiarity with the morphologic and immunophenotypic spectrum of DHL is important in directing testing to detect concurrent IGH-BCL2 and MYC rearrangements when a karyotype is unavailable. The aggressive clinical behavior and combination of genetic abnormalities seen in these cases may warrant categorization as a separate entity in future classifications and call for novel therapeutic approaches.

Rituximab-dose-dense chemotherapy with or without high-dose chemotherapy plus autologous stem-cell transplantation in high-risk diffuse large B-cell lymphoma (DLCL04): final results of a multicentre, open-label, randomised, controlled, phase 3 study.

PubMed

Chiappella, Annalisa; Martelli, Maurizio; Angelucci, Emanuele; Brusamolino, Ercole; Evangelista, Andrea; Carella, Angelo Michele; Stelitano, Caterina; Rossi, Giuseppe; Balzarotti, Monica; Merli, Francesco; Gaidano, Gianluca; Pavone, Vincenzo; Rigacci, Luigi; Zaja, Francesco; D'Arco, Alfonso; Cascavilla, Nicola; Russo, Eleonora; Castellino, Alessia; Gotti, Manuel; Congiu, Angela Giovanna; Cabras, Maria Giuseppina; Tucci, Alessandra; Agostinelli, Claudio; Ciccone, Giovannino; Pileri, Stefano A; Vitolo, Umberto

2017-08-01

The prognosis of young patients with diffuse large B-cell lymphoma at high risk (age-adjusted International Prognostic Index [aa-IPI] score 2 or 3) treated with R-CHOP (rituximab, cyclophosphamide, vincristine, doxorubicin, and prednisone) is poor. The aim of this study was to investigate the possible benefit of intensification with high-dose chemotherapy and autologous stem-cell transplantation as part of first-line treatment in these patients. We did a multicentre, open-label, randomised, controlled, phase 3 trial with a 2 × 2 factorial design to compare, at two different R-CHOP dose levels, a full course of rituximab-dose-dense chemotherapy (no transplantation group) versus an abbreviated course of rituximab-dose-dense chemotherapy followed by consolidation with R-MAD (rituximab plus high-dose cytarabine plus mitoxantrone plus dexamethasone) and high-dose BEAM chemotherapy (carmustine, etoposide, cytarabine, and melphalan) plus autologous stem-cell transplantation (transplantation group) in young patients (18-65 years) with untreated high-risk diffuse large B-cell lymphoma (aa-IPI score 2-3). At enrolment, patients were stratified according to aa-IPI score and randomly assigned (1:1:1:1) to receive R-CHOP (intravenous rituximab 375 mg/m 2 , cyclophosphamide 750 mg/m 2 , doxorubicin 50 mg/m 2 , and vincristine 1·4 mg/m 2 on day 1, plus oral prednisone 100 mg on days 1-5) delivered in a 14-day cycle (R-CHOP-14) for eight cycles; high-dose R-CHOP-14 (R-MegaCHOP-14; R-CHOP-14 except for cyclophosphamide 1200 mg/m 2 and doxorubicin 70 mg/m 2 ) for six cycles; R-CHOP-14 for four cycles followed by R-MAD (intravenous rituximab 375 mg/m 2 on day 1 or 4 plus intravenous cytarabine 2000 mg/m 2 and dexamethasone 4 mg/m 2 every 12 h on days 1-3 plus intravenous mitoxantrone 8 mg/m 2 on days 1-3) plus BEAM (intravenous carmustine 300 mg/m 2 on day -7, intravenous cytarabine 200 mg/m 2 twice a day on days -6 to -3, intravenous etoposide 100 mg/m 2 twice a day on days -6 to -3, plus intravenous melphalan 140 mg/m 2 on day -2) and autologous stem-cell transplantation (day 0); or R-MegaCHOP-14 for four cycles followed by R-MAD plus BEAM and autologous stem-cell transplantation. The primary endpoint was failure-free survival at 2 years in the intention-to-treat population. This study is registered with EudraCT (2005-002181-14; 2007-000275-42) and with ClinicalTrials.gov, number NCT00499018. Between Jan 10, 2006, and Sept 8, 2010, 399 patients were randomly assigned to receive transplantation (n=199) or no transplantation (n=200); 203 patients were assigned to receive R-CHOP-14 and 196 were assigned to receive R-MegaCHOP-14. With a median follow-up of 72 months (IQR 57-88), 2-year failure-free survival was 71% (95% CI 64-77) in the transplantation group versus 62% (95% CI 55-68) in the no transplantation group (hazard ratio [HR] 0·65 [95% CI 0·47-0·91]; stratified log-rank test p=0·012). No difference in 5-year overall survival was observed between these groups (78% [95% CI 71-83] versus 77% [71-83]; HR 0·98 [0·65-1·48]; stratified log-rank test p=0·91). Grade 3 or worse haematological adverse events were reported in 183 (92%) of 199 patients in the transplantation group versus 135 (68%) of 200 patients in the no transplantation group. Grade 3 or worse non-haematological adverse events were reported in 90 (45%) versus 31 (16%); the most common grade 3 or worse non-haematological adverse event was gastrointestinal (49 [25%] vs 19 [10%]). Treatment-related deaths occurred in 13 (3%) patients; eight in the transplantation group and five in the no transplantation group. Abbreviated rituximab-dose-dense chemotherapy plus R-MAD plus BEAM and autologous stem-cell transplantation reduced the risk of treatment failure compared with full course rituximab-dose-dense chemotherapy in young patients with diffuse large B-cell lymphoma at high risk. However, these results might not be clinically meaningful, since this improvement did not reflect an improvement in overall survival. These results do not support further consideration of the use of intensification of R-CHOP as an upfront strategy in patients with diffuse large B-cell lymphoma with poor prognosis. Fondazione Italiana Linfomi. Copyright © 2017 Elsevier Ltd. All rights reserved.

Potential Uses of EarthSLOT (an Earth Science, Logistics, and Outreach Terrainbase) for Education and Integration in the International Polar Year

NASA Astrophysics Data System (ADS)

Nolan, M.

2004-12-01

EarthSLOT is an internet-based, 3D, interactive terrain and data visualization system that may have many potential uses as an education and integration tool for International Polar Year projects. Recently funded by NSF's Office of Polar Programs for use in the Arctic, the global nature of the application lends itself well for use at both poles and everywhere in between. The application allows one to start with a spinning earth and zoom down to surface level. The highest resolution digital elevation models available provide the necessary 3D topographic perspective and a variety of possible high-resolution satellite and aerial imagery layers add surface realism; resolution can be down to the centimeter level for either type of data, and frequently acquired satellite imagery may be updated automatically as it arrives. Superimposed on this can be nearly any form of vector or annotation layers, such as shapefiles, polygons, point data, and 3D models (still and moving), which can be easily imported from existing GIS applications or spreadsheets. External databases can also be queried and the results served seamlessly. The entire application is served over the internet, and any connection with speeds over 300kps allows one to interactively fly with a minimum of performance lag. EarthSLOT stands for Earth Science, Logistics, and Outreach Terrainbase, targeting the user-groups of scientists, logisticians, and the public. Approved scientific users can add their own vector content to the application on their own, such that they can create their own custom applications featuring their data but using our underlying earth model with a minimum of interaction with us. For example, an oceanographer can add ship tracks or buoy locations to the model with links to data, host the link on his or her own web page, and invite collaborators to view the spatial relationship of their data to underlying bathymetry. Logisticians or program managers interested in understanding the spatial relationships between different projects for the purposes of coordinating or facilitating cost sharing of logistics can add layers that show the locations and timing of their projects. Educators or principle investigators interested in outreach can design and implement custom applications to share the motivation, rationale, and results of their work in a large variety of ways. Each of these applications can be freely-shared or password-protected, depending on their nature, on either project home pages or on a central IPY-EarthSLOT site. Our prototype application can be found on-line at www.earthslot.org. We already have substantial Landsat coverage of the Arctic, and in the near future plan to incorporate high resolution mosaics of Greenland and Antarctica. With modest additional funding, we propose that EarthSLOT could be used a central integration tool for projects related to the International Polar Year.

Verification of Empirical Method for Determining Riverbank Stability. Report 19. Report 12-24 - 1974 through 1977 Data.

DTIC Science & Technology

1981-02-01

Cairo, Ill. Blaker Towhead, Tenn. Wolf Island, Vy. Obion-Tamm, Tenn. Hickman- Reelfoot , Ky. Kate Aubrey, Tenn. Island No. 8, Ky. Harbert Point, Miss...MEfIPI S DkISTRICI 20 Porter Lake , Ark., Failur. was first repo 701 mA P I-ft blufI bank 276+00 to 278+00 1966 May Jun 5 12-4 20 28+ 0.71...and La., 447 MAHP R-4-U to R-2-Uj 1955 0 R-2-U to R-0 one boring location** 1956 0 40 39 1.02 R-3-U 1958 150 Lake Karnac, Miss., 419 MAHP R-111-D to

Numerical Evaluation of the Wake-Survey Equations for Subsonic Flow Including the Effect of Energy Addition

DTIC Science & Technology

1945-11-01

1016 1 ..1526::j~~ -.20~6 ::$? j%j :j3~~ ++: ::&zt 1:~8~ -“.0280li.027h!=.02701~. 26hl=.025811.0 52 -.9%581-.9546l-.9k3~93i93i I 1 IPI ~ g q. 0.80c :2...0.50 ] 0.55 0.60 ------ ------ ------ ------ ).0334 .100 .10 $.094 ;;~~ .029 .0154 I ..0160 -.0348 -.0504 -.0692 -.1064 !4 -.1 64 -.184 ::g~ -.5222 -. 624 ...y:~ .150 .100 . 0786 .075 .0 96 i.050 .0 00 .02j .0200 ) %! %;! ..100-.0838 ..150-.1272 ..200-.1716 ..250-.2168 ::%J ::~%; ‘“600::25:8 ::6::-.7

Advanced Radar Reflector Studies

DTIC Science & Technology

1975-12-01

1 »«P21«PZ2 "ATA HI,lP,LT«/3.l’H5n,6.26Sl»,3T6.727/ HATA C.ll/tO.O.-.’jJOIKlF-?!/ r«LL tSC(»919) WhllrC.T) T r(iRi> lAT (lXt...UNLIMITED, m^m ■jmwmsmi ,-Ul!l.M*J4J4». l-!l!ipiJ’ [ 1 1 u i 1 i. k pi I Ni, Ü L L u i D B*.-** 1 1 p | ! Ml |i M * H L... 1 f’’■’ ■ i ! 1 J 0 .^ mm vnwmm " II.IIIIIPW UNCLASSIFIED SECURITY CLASSIFICATION

Brain glucose metabolism in diffuse large B-cell lymphoma patients as assessed with FDG-PET: impact on outcome and chemotherapy effects.

PubMed

Adams, Hugo Ja; de Klerk, John Mh; Fijnheer, Rob; Heggelman, Ben Gf; Dubois, Stefan V; Nievelstein, Rutger Aj; Kwee, Thomas C

2016-06-01

There is a lack of data on the effect of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy on brain glucose metabolism of diffuse large B-cell lymphoma (DLBCL) patients, as measured by 18F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET). Moreover, the prognostic value of brain glucose metabolism measurements is currently unknown. To investigate the use of FDG-PET for measurement of brain glucose metabolism in R-CHOP-treated DLBCL patients, and to assess its prognostic value. This retrospective study included DLBCL patients who underwent FDG-PET including the brain. FDG-PET metabolic volume products (MVPs) of the entire brain, cerebral cortex, basal ganglia, and cerebellum were measured, before and after R-CHOP therapy. Whole-body total lesion glycolysis (TLG) was also measured. Thirty-eight patients were included, of whom 18 had an appropriate end-of-treatment FDG-PET scan. There were no significant differences (P > 0.199) between pre- and post-treatment brain glucose metabolism metrics. Low basal ganglia MVP was associated with a significantly worse progression-free survival (PFS) and overall survival (OS) (P = 0.020 and P = 0.032), and low cerebellar MVP was associated with a significantly worse OS (P = 0.034). There were non-significant very weak correlations between pretreatment brain glucose metabolism metrics and TLG. In the multivariate Cox regression, only the National Comprehensive Cancer Network International Prognostic Index (NCCN-IPI) remained an independent predictor of PFS (hazard ratio 3.787, P = 0.007) and OS (hazard ratio 2.903, P = 0.0345). Brain glucose metabolism was not affected by R-CHOP therapy. Low pretreatment brain glucose metabolism was associated with a worse outcome, but did not surpass the predictive value of the NCCN-IPI. © The Foundation Acta Radiologica 2015.

Bone Ceramic® at Implants Installed Immediately into Extraction Sockets in the Molar Region: An Experimental Study in Dogs.

PubMed

Pereira, Flávia Priscila; Hochuli-Vieira, Eduardo; Maté Sánchez de Val, José E; De Santis, Enzo; Salata, Luiz Antonio; Botticelli, Daniele

2016-04-01

The aim of this paper was to study the healing of 1-1.4 mm wide buccal defects at implants placed immediately into extraction sockets (IPIES) filled with a mixture of synthetic hydroxyapatite (HA) 60% and beta-tricalciumphosphate (TCP) 40% or left with the clot alone and both covered with collagen membranes. Eight Labrador dogs were used and implants were placed immediately into the extraction sockets of the first molar bilaterally. A mixture of synthetic HA 60% and beta-TCP 40% at the test or the clot alone at the control sites were used to fill the defects. All surgical sites were subsequently covered by a resorbable collagen membrane and a non-submerged healing was allowed. After 4 months, the animals were euthanized, biopsies harvested and processed for histomorphometric analysis. At the time of installation, residual buccal defects occurred that were 1.1 mm and 1.4 mm wide and 3 mm and 4 mm deep at the control and test sites, respectively. After 4 months of healing, the top of the bony crest and the coronal level of osseointegration were located respectively at 0.1 ± 1.8 mm and 1.5 ± 1.8 mm at the test, and 0.6 ± 1.6 mm and 1.2 ± 0.7 mm at the control sites apically to the implant shoulder. Bone-to-implant contact at the buccal aspect was 34.9 ± 25.9% and 36.4 ± 17.3% at the test and control sites, respectively. No statistically significant differences were found between test and control sites for any of the variables analyzed at the buccal aspects. The use of a mixture of synthetic HA 60% and beta-TCP 40% to fill residual buccal defects 1-1.4 mm wide at IPIES did not improve significantly the results of healing. © 2015 Wiley Periodicals, Inc.

Community Structure Analysis of Transcriptional Networks Reveals Distinct Molecular Pathways for Early- and Late-Onset Temporal Lobe Epilepsy with Childhood Febrile Seizures

PubMed Central

Moreira-Filho, Carlos Alberto; Bando, Silvia Yumi; Bertonha, Fernanda Bernardi; Iamashita, Priscila; Silva, Filipi Nascimento; Costa, Luciano da Fontoura; Silva, Alexandre Valotta; Castro, Luiz Henrique Martins; Wen, Hung-Tzu

2015-01-01

Age at epilepsy onset has a broad impact on brain plasticity and epilepsy pathomechanisms. Prolonged febrile seizures in early childhood (FS) constitute an initial precipitating insult (IPI) commonly associated with mesial temporal lobe epilepsy (MTLE). FS-MTLE patients may have early disease onset, i.e. just after the IPI, in early childhood, or late-onset, ranging from mid-adolescence to early adult life. The mechanisms governing early (E) or late (L) disease onset are largely unknown. In order to unveil the molecular pathways underlying E and L subtypes of FS-MTLE we investigated global gene expression in hippocampal CA3 explants of FS-MTLE patients submitted to hippocampectomy. Gene coexpression networks (GCNs) were obtained for the E and L patient groups. A network-based approach for GCN analysis was employed allowing: i) the visualization and analysis of differentially expressed (DE) and complete (CO) - all valid GO annotated transcripts - GCNs for the E and L groups; ii) the study of interactions between all the system’s constituents based on community detection and coarse-grained community structure methods. We found that the E-DE communities with strongest connection weights harbor highly connected genes mainly related to neural excitability and febrile seizures, whereas in L-DE communities these genes are not only involved in network excitability but also playing roles in other epilepsy-related processes. Inversely, in E-CO the strongly connected communities are related to compensatory pathways (seizure inhibition, neuronal survival and responses to stress conditions) while in L-CO these communities harbor several genes related to pro-epileptic effects, seizure-related mechanisms and vulnerability to epilepsy. These results fit the concept, based on fMRI and behavioral studies, that early onset epilepsies, although impacting more severely the hippocampus, are associated to compensatory mechanisms, while in late MTLE development the brain is less able to generate adaptive mechanisms, what has implications for epilepsy management and drug discovery. PMID:26011637

Recovery cycle times of inferior colliculus neurons in the awake bat measured with spike counts and latencies

PubMed Central

Sayegh, Riziq; Aubie, Brandon; Fazel-Pour, Siavosh; Faure, Paul A.

2012-01-01

Neural responses in the mammalian auditory midbrain (inferior colliculus; IC) arise from complex interactions of synaptic excitation, inhibition, and intrinsic properties of the cell. Temporally selective duration-tuned neurons (DTNs) in the IC are hypothesized to arise through the convergence of excitatory and inhibitory synaptic inputs offset in time. Synaptic inhibition can be inferred from extracellular recordings by presenting pairs of pulses (paired tone stimulation) and comparing the evoked responses of the cell to each pulse. We obtained single unit recordings from the IC of the awake big brown bat (Eptesicus fuscus) and used paired tone stimulation to measure the recovery cycle times of DTNs and non-temporally selective auditory neurons. By systematically varying the interpulse interval (IPI) of the paired tone stimulus, we determined the minimum IPI required for a neuron's spike count or its spike latency (first- or last-spike latency) in response to the second tone to recover to within ≥50% of the cell's baseline count or to within 1 SD of it's baseline latency in response to the first tone. Recovery times of shortpass DTNs were significantly shorter than those of bandpass DTNs, and recovery times of bandpass DTNs were longer than allpass neurons not selective for stimulus duration. Recovery times measured with spike counts were positively correlated with those measured with spike latencies. Recovery times were also correlated with first-spike latency (FSL). These findings, combined with previous studies on duration tuning in the IC, suggest that persistent inhibition is a defining characteristic of DTNs. Herein, we discuss measuring recovery times of neurons with spike counts and latencies. We also highlight how persistent inhibition could determine neural recovery times and serve as a potential mechanism underlying the precedence effect in humans. Finally, we explore implications of recovery times for DTNs in the context of bat hearing and echolocation. PMID:22933992

Maintaining a Cognitive Map in Darkness: The Need to Fuse Boundary Knowledge with Path Integration

PubMed Central

Cheung, Allen; Ball, David; Milford, Michael; Wyeth, Gordon; Wiles, Janet

2012-01-01

Spatial navigation requires the processing of complex, disparate and often ambiguous sensory data. The neurocomputations underpinning this vital ability remain poorly understood. Controversy remains as to whether multimodal sensory information must be combined into a unified representation, consistent with Tolman's “cognitive map”, or whether differential activation of independent navigation modules suffice to explain observed navigation behaviour. Here we demonstrate that key neural correlates of spatial navigation in darkness cannot be explained if the path integration system acted independently of boundary (landmark) information. In vivo recordings demonstrate that the rodent head direction (HD) system becomes unstable within three minutes without vision. In contrast, rodents maintain stable place fields and grid fields for over half an hour without vision. Using a simple HD error model, we show analytically that idiothetic path integration (iPI) alone cannot be used to maintain any stable place representation beyond two to three minutes. We then use a measure of place stability based on information theoretic principles to prove that featureless boundaries alone cannot be used to improve localization above chance level. Having shown that neither iPI nor boundaries alone are sufficient, we then address the question of whether their combination is sufficient and – we conjecture – necessary to maintain place stability for prolonged periods without vision. We addressed this question in simulations and robot experiments using a navigation model comprising of a particle filter and boundary map. The model replicates published experimental results on place field and grid field stability without vision, and makes testable predictions including place field splitting and grid field rescaling if the true arena geometry differs from the acquired boundary map. We discuss our findings in light of current theories of animal navigation and neuronal computation, and elaborate on their implications and significance for the design, analysis and interpretation of experiments. PMID:22916006

The Recognition and Evaluation of Patterns of Compensatory Injury in Patients With Mechanical Hip Pain

PubMed Central

Hammoud, Sommer; Bedi, Asheesh; Voos, James E.; Mauro, Craig S.; Kelly, Bryan T.

2014-01-01

Context: In active individuals with femoroacetabular impingement (FAI), the resultant reduction in functional range of motion leads to high impaction loads at terminal ranges. These increased forces result in compensatory effects on bony and soft tissue structures within the hip joint and hemipelvis. An algorithm is useful in evaluating athletes with pre-arthritic, mechanical hip pain and associated compensatory disorders. Evidence Acquisition: A literature search was performed by a review of PubMed articles published from 1976 to 2013. Level of Evidence: Level 4. Results: Increased stresses across the bony hemipelvis result when athletes with FAI attempt to achieve supraphysiologic, terminal ranges of motion (ROM) through the hip joint required for athletic competition. This can manifest as pain within the pubic joint (osteitis pubis), sacroiliac joint, and lumbosacral spine. Subclinical posterior hip instability may result when attempts to increase hip flexion and internal rotation are not compensated for by increased motion through the hemipelvis. Prominence of the anterior inferior iliac spine (AIIS) at the level of the acetabular rim can result in impingement of the anterior hip joint capsule or iliocapsularis muscle origin against the femoral head-neck junction, resulting in a distinct form of mechanical hip impingement (AIIS subspine impingement). Iliopsoas impingement (IPI) has also been described as an etiology for anterior hip pain. IPI results in a typical 3-o’clock labral tear as well as an inflamed capsule in close proximity to the overlying iliopsoas tendon. Injury in athletic pubalgia occurs during high-energy twisting activities in which abnormal hip ROM and resultant pelvic motion lead to shearing across the pubic symphysis. Conclusion: Failure to recognize and address concomitant compensatory injury patterns associated with intra-articular hip pathology can result in significant disability and persistent symptoms in athletes with pre-arthritic, mechanical hip pain. Strength-of-Recommendation Taxonomy (SORT): B PMID:24587859

O-O Radical Coupling: From Detailed Mechanistic Understanding to Enhanced Water Oxidation Catalysis.

PubMed

Xie, Yan; Shaffer, David W; Concepcion, Javier J

2018-04-30

A deeper mechanistic understanding of the key O-O bond formation step of water oxidation by the [Ru(bda)(L) 2 ] (bdaH 2 = 2,2'-bipyridine-6,6'-dicarboxylic acid; L is a pyridine or isoquinoline derivative) family of catalysts is reached through harmonious experimental and computational studies of two series of modified catalysts with systematic variations in the axial ligands. The introduction of halogen and electron-donating substituents in [Ru(bda)(4-X-py) 2 ] and [Ru(bda)(6-X-isq) 2 ] (X is H, Cl, Br, and I for the pyridine series and H, F, Cl, Br, and OMe for the isoquinoline series) enhances the noncovalent interactions between the axial ligands in the transition state for the bimolecular O-O coupling, resulting in a lower activation barrier and faster catalysis. From detailed transition state calculations in combination with experimental kinetic studies, we find that the main contributor to the free energy of activation is entropy due to the highly organized transition states, which is contrary to other reports. Previous work has considered only the electronic influence of the substituents, suggesting electron-withdrawing groups accelerate catalysis, but we show that a balance between polarizability and favorable π-π interactions is the key, leading to rationally devised improvements. Our calculations predict the catalysts with the lowest Δ G ⧧ for the O-O coupling step to be [Ru(bda)(4-I-py) 2 ] and [Ru(bda)(6,7-(OMe) 2 -isq) 2 ] for the pyridine and isoquinoline families, respectively. Our experimental results corroborate these predictions: the turnover frequency for [Ru(bda)(4-I-py) 2 ] (330 s -1 ) is a 10-fold enhancement with respect to that of [Ru(bda)(py) 2 ], and the turnover frequency for [Ru(bda)(6-OMe-isq) 2 ] reaches 1270 s -1 , two times faster than [Ru(bda)(isq) 2 ].

Adolescents' multiple versus single primary attachment figures, reorganization of attachment hierarchy, and adjustments: the important people interview approach.

PubMed

Umemura, Tomotaka; Lacinová, Lenka; Kraus, Jakub; Horská, Eliška; Pivodová, Lenka

2018-04-20

Using 212 adolescents from a central-European country (mean age = 14.02, SD = 2.05, ranged from 11 to 18 years; females = 54%) and a multi-informant method to measure adolescents' behavioral and emotional adjustments, the present study explored three aspects regarding the attachment hierarchy. (1) The three types of behavioral systems of Rosenthal and Kobak's important people interview (IPI) were initially validated using an exploratory factor analysis with a US sample. Using a confirmatory factor analysis with a Czech sample, we replicated these three behavioral systems: attachment bond, support seeking, and affiliation. (2) We found that adolescents who developed attachment bond to multiple primary attachment figures were likely to score lower on both teacher-rated and parent-rated internalizing problems compared to those who had a single primary attachment figure. These multiple primary attachment figures tended to be family members (not peers). (3) Early adolescents who placed parents low in their attachment hierarchy scored higher on self-reported negative affect and lower on self-reported positive affect compared to early adolescents who placed parents high. The present study highlights multiple (vs. single) primary attachment figures as a protective factor and the premature reorganization of attachment hierarchy as a risk factor for adolescents' emotional and affective adjustments.

Connecting Texas to the Poles - IPY outreach at the University of Texas Institute for Geophysics

NASA Astrophysics Data System (ADS)

Stevenoski, S.; Lawver, L.

2007-12-01

This outreach effort at UTIG targets high school teachers and students during the International Polar Year. Four individual activities were designed using a constructivist approach. The activities were integrated into a new website at UTIG specifically designed to help researchers connect with students and teachers. The website and activities serve as a starting point for the scientists to potentially get more involved with individual classrooms and traditional professional science organizations. Students will use accepted scientific knowledge, models, and theories to explain their results and to raise further questions about their investigations. Students will state what they have learned from investigations, relating their inferences to scientific knowledge and to data they have collected. They will explain their data and conclusions in ways that allow others to understand the inquiry that they have conducted. The activities are based upon data sets modified for student use from the UT Polar science community. These Polar data sets will complement student data acquired during the hands on activities central to the student inquiry lessons. The activities are range from traditional classroom lab investigations to Internet based georeferencing and mapping. Researchers and graduate students were actively involved in the development of the final products to insure the accuracy of the science and data used.