Cumulative incidence and prevalence of childhood autism in children in Japan.

PubMed

Honda, H; Shimizu, Y; Misumi, K; Niimi, M; Ohashi, Y

1996-08-01

An epidemiological survey of childhood autism as defined in ICD-10 Research Criteria was conducted in the northern part of Yokohama, Japan. The routine health checkup for 18-month-old children served as the initial mass-screening, and all facilities which provide child care services function to detect all cases with childhood autism and refer them to the Yokohama Rehabilitation Centre. Cumulative incidence of childhood autism up to 5 years of age among the birth cohort of 1988, and prevalence on 1 January 1994, among residents born in 1988 were estimated Cumulative incidence and prevalence were 16.2 per 10,000 and 21.1 per 10,000, respectively. Children with high-functioning autism who had IQs of 70 and over constituted approximately half of all the children with childhood autism. CONCLUSION. It was confirmed through better detection of high-functioning cases that childhood autism in Japan is more common than formerly estimated.

Occurrence, distribution and prey items of juvenile marbled sole Pseudopleuronectes yokohamae around a submarine groundwater seepage on a tidal flat in southwestern Japan

NASA Astrophysics Data System (ADS)

Hata, Masaki; Sugimoto, Ryo; Hori, Masakazu; Tomiyama, Takeshi; Shoji, Jun

2016-05-01

Occurrence, distribution and prey items of juvenile marbled sole Pseudopleuronectes yokohamae were investigated around a submarine groundwater seepage on a tidal flat in southwestern Japan. Spatial distribution of radon-222 (222Rn) concentration in water showed more submarine groundwater seepage in the offshore area. The lower salinities at offshore sampling stations corresponded with the highest 222Rn concentrations. Juvenile marbled sole were collected from March through June with seasonal peak in April in 2013 and 2014. Mean abundance of juvenile marbled sole was highest at the second most offshore station where high submarine groundwater seepage was indicated. Major prey items in the stomachs of the marbled sole at the post-settlement stage (10-40 mm) were small crustaceans such as cumaceans and gammarids, which were partially replaced with polychaetes in larger juveniles (40-50 mm). Abundance of these major prey items was also higher at offshore stations. A negative correlation between gammarid abundance and salinity indicated a higher concentration of gammarids around the area of high submarine groundwater seepage, a pattern not observed for the other major prey organisms. Stable isotope analysis showed greater dependence of post-settlement stage marbled sole on the small crustaceans with low δ13C indicating that nutrients of terrestrial origin contribute to production of the juvenile marbled sole on the tidal flat.

28 CFR 22.23 - Privacy certification.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Privacy certification. 22.23 Section 22... STATISTICAL INFORMATION § 22.23 Privacy certification. (a) Each applicant for BJA, OJJDP, BJS, NIJ, or OJP support either directly or under a State plan shall submit a Privacy Certificate as a condition of...

28 CFR 22.23 - Privacy certification.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Privacy certification. 22.23 Section 22... STATISTICAL INFORMATION § 22.23 Privacy certification. (a) Each applicant for BJA, OJJDP, BJS, NIJ, or OJP support either directly or under a State plan shall submit a Privacy Certificate as a condition of...

28 CFR 22.23 - Privacy certification.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Privacy certification. 22.23 Section 22... STATISTICAL INFORMATION § 22.23 Privacy certification. (a) Each applicant for BJA, OJJDP, BJS, NIJ, or OJP support either directly or under a State plan shall submit a Privacy Certificate as a condition of...

28 CFR 22.23 - Privacy certification.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Privacy certification. 22.23 Section 22... STATISTICAL INFORMATION § 22.23 Privacy certification. (a) Each applicant for BJA, OJJDP, BJS, NIJ, or OJP support either directly or under a State plan shall submit a Privacy Certificate as a condition of...

Psychology in Japan.

PubMed

Imada, Hiroshi; Tanaka-Matsumi, Junko

2016-06-01

The purpose of this article is to provide information about Japan and its psychology in advance of the 31st International Congress of Psychology (ICP), to be held in Yokohama, Japan, in 2016. The article begins with the introduction of the Japanese Psychological Association (JPA), the hosting organization of the ICP 2016, and the Japanese Union of Psychological Associations consisting of 51 associations/societies, of which the JPA is a member. This is followed by a brief description of a history of psychology of Japan, with emphasis on the variation in our approach to psychology in three different periods, that is, the pre- and post-Pacific War periods, and the post-1960 period. Next, the international contributions of Japanese psychology/psychologists are discussed from the point of view of their visibility. Education and training in psychology in Japanese universities is discussed with a final positive remark about the long-awaited enactment of the Accredited Psychologist Law in September, 2015. © 2016 International Union of Psychological Science.

23 CFR 1200.22 - Changes.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Changes. 1200.22 Section 1200.22 Highways NATIONAL... Implementation and Management of the Highway Safety Program § 1200.22 Changes. States shall provide documentary... amended HS form 217 (or its electronic equivalent), reflecting the changed allocation of funds, within 30...

40 CFR 413.22-413.23 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 413.22-413.23 Section 413.22-413.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ELECTROPLATING POINT SOURCE CATEGORY Electroplating of Precious Metals Subcategory §§ 413.22-413...

22 CFR 401.23 - Hearings.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Hearings. 401.23 Section 401.23 Foreign Relations INTERNATIONAL JOINT COMMISSION, UNITED STATES AND CANADA RULES OF PROCEDURE Applications § 401.23 Hearings. (a) The time and place of the hearing or hearings of an application shall be fixed by the...

22 CFR 707.23 - Fees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Fees. 707.23 Section 707.23 Foreign Relations... INFORMATION IN RECORDS OF THE CORPORATION Notification; Access to Records; Amendment; Fees § 707.23 Fees. The fees to be charged by the Corporation for making copies of any records provided to any individual under...

22 CFR 120.23 - Distribution agreement.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Distribution agreement. 120.23 Section 120.23 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.23 Distribution agreement. An agreement (e.g., a contract) to establish a warehouse or...

22 CFR 120.23 - Distribution agreement.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Distribution agreement. 120.23 Section 120.23 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.23 Distribution agreement. An agreement (e.g., a contract) to establish a warehouse or...

22 CFR 120.23 - Distribution agreement.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Distribution agreement. 120.23 Section 120.23 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.23 Distribution agreement. An agreement (e.g., a contract) to establish a warehouse or...

22 CFR 120.23 - Distribution agreement.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Distribution agreement. 120.23 Section 120.23 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.23 Distribution agreement. An agreement (e.g., a contract) to establish a warehouse or...

22 CFR 120.23 - Distribution agreement.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Distribution agreement. 120.23 Section 120.23 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.23 Distribution agreement. An agreement (e.g., a contract) to establish a warehouse or...

22 CFR 401.23 - Hearings.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Hearings. 401.23 Section 401.23 Foreign... Hearings. (a) The time and place of the hearing or hearings of an application shall be fixed by the... of the hearing or hearings to the applicant, the Governments and all persons who have presented...

22 CFR 401.23 - Hearings.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Hearings. 401.23 Section 401.23 Foreign... Hearings. (a) The time and place of the hearing or hearings of an application shall be fixed by the... of the hearing or hearings to the applicant, the Governments and all persons who have presented...

22 CFR 401.23 - Hearings.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Hearings. 401.23 Section 401.23 Foreign... Hearings. (a) The time and place of the hearing or hearings of an application shall be fixed by the... of the hearing or hearings to the applicant, the Governments and all persons who have presented...

22 CFR 92.23 - Taking an affidavit.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Taking an affidavit. 92.23 Section 92.23 Foreign Relations DEPARTMENT OF STATE LEGAL AND RELATED SERVICES NOTARIAL AND RELATED SERVICES Specific...) Administer the oath to the affiant before the affiant signs the affidavit. [22 FR 10858, Dec. 27, 1957, as...

22 CFR 217.23 - New construction.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false New construction. 217.23 Section 217.23 Foreign... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Accessibility § 217.23 New construction. (a) Design and construction. Each facility or part of a facility constructed by, on behalf of, or for the use of a recipient...

22 CFR 217.23 - New construction.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false New construction. 217.23 Section 217.23 Foreign... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Accessibility § 217.23 New construction. (a) Design and construction. Each facility or part of a facility constructed by, on behalf of, or for the use of a recipient...

22 CFR 212.23 - Current index.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Current index. 212.23 Section 212.23 Foreign... Inspection and Copying § 212.23 Current index. USAID maintains and makes available for public inspection and copying a current index providing identifying information for the public as to any matter which has been...

32. SPILLWAY CHANNEL WALLS REINF. DETAILS; MONOLITHS E22, E23, W22, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

32. SPILLWAY CHANNEL WALLS REINF. DETAILS; MONOLITHS E-22, E-23, W-22, AND W-23. Sheet S-46, May, 1940. File no. 342/59. - Prado Dam, Spillway, Santa Ana River near junction of State Highways 71 & 91, Corona, Riverside County, CA

Maintenance Downtime August 22, 23, 29, 30, 2014

Atmospheric Science Data Center

2014-08-28

... Friday, August 22, 2014 to Saturday, August 23, 2014 Time:  07:00 pm - 08:00 am EDT Event ... on Friday evening through Saturday morning on Aug. 22-23, and again on Aug. 29-30. Periods of intermittent network outages will occur ...

22 CFR 192.23 - Administration of benefits.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Administration of benefits. 192.23 Section 192.23 Foreign Relations DEPARTMENT OF STATE HOSTAGE RELIEF VICTIMS OF TERRORISM COMPENSATION Application of Soldiers' and Sailors' Civil Relief Act to Captive Situations § 192.23 Administration of benefits...

22 CFR 51.23 - Identity of applicant.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Identity of applicant. 51.23 Section 51.23 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Application § 51.23 Identity of... establish his or her identity by the submission of a previous passport, other state, local, or federal...

22 CFR 51.23 - Identity of applicant.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Identity of applicant. 51.23 Section 51.23 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Application § 51.23 Identity of... establish his or her identity by the submission of a previous passport, other state, local, or federal...

22 CFR 51.23 - Identity of applicant.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Identity of applicant. 51.23 Section 51.23 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Application § 51.23 Identity of... establish his or her identity by the submission of a previous passport, other state, local, or federal...

22 CFR 51.23 - Identity of applicant.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Identity of applicant. 51.23 Section 51.23 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Application § 51.23 Identity of... establish his or her identity by the submission of a previous passport, other state, local, or federal...

22 CFR 51.23 - Identity of applicant.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Identity of applicant. 51.23 Section 51.23 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Application § 51.23 Identity of... establish his or her identity by the submission of a previous passport, other state, local, or federal...

Associations between seasonal meteorological conditions and the daily step count of adults in Yokohama, Japan: Results of year-round pedometer measurements in a large population.

PubMed

Hino, Kimihiro; Lee, Jung Su; Asami, Yasushi

2017-12-01

People's year-round interpersonal step count variations according to meteorological conditions are not fully understood, because complete year-round data from a sufficient sample of the general population are difficult to acquire. This study examined the associations between meteorological conditions and objectively measured step counts using year-round data collected from a large cohort ( N  = 24,625) in Yokohama, Japan from April 2015 to March 2016. Two-piece linear regression analysis was used to examine the associations between the monthly median daily step count and three meteorological indices (mean values of temperature, temperature-humidity index (THI), and net effective temperature (NET)). The number of steps per day peaked at temperatures between 19.4 and 20.7 °C. At lower temperatures, the increase in steps per day was between 46.4 and 52.5 steps per 1 °C increase. At temperatures higher than those at which step counts peaked, the decrease in steps per day was between 98.0 and 187.9 per 1 °C increase. Furthermore, these effects were more obvious in elderly than non-elderly persons in both sexes. A similar tendency was seen when using THI and NET instead of temperature. Among the three meteorological indices, the highest R 2 value with step counts was observed with THI in all four groups. Both high and low meteorological indices discourage people from walking and higher values of the indices adversely affect step count more than lower values, particularly among the elderly. Among the three indices assessed, THI best explains the seasonal fluctuations in step counts.

Expedition 22 Change of Command in the U.S. Laboratory

NASA Image and Video Library

2010-03-17

ISS022-E-100364 (17 March 2010) --- Crew members aboard the International Space Station are pictured in the Destiny laboratory during the ceremony of Changing-of-Command from Expedition 22 to Expedition 23. Pictured from the right are NASA astronauts Jeffrey Williams, Expedition 22 commander; and T.J. Creamer, Expedition 22/23 flight engineer; Russian cosmonauts Oleg Kotov, Expedition 22 flight engineer and Expedition 23 commander; and Maxim Suraev, Expedition 22 flight engineer. Not pictured is Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, Expedition 22/23 flight engineer.

Prevalence of Functional Constipation and Relationship with Dietary Habits in 3- to 8-Year-Old Children in Japan.

PubMed

Fujitani, Asami; Sogo, Tsuyoshi; Inui, Ayano; Kawakubo, Kiyoshi

2018-01-01

To determine the prevalence and effect of dietary habits on functional constipation in preschool and early elementary school children in Japan. A total of 3595 children aged 3 to 8 years from 28 nursery schools and 22 elementary schools in Yokohama City, Kanagawa Prefecture, Japan, were evaluated. The subjects were divided into a functional constipation group and a nonfunctional constipation group according to the Rome III criteria. Dietary intake data were collected using a brief-type, self-administered, diet-history questionnaire validated for Japanese preschool-aged children. Of the 3595 subjects evaluated, 718 (20.0%) had functional constipation. The association between functional constipation and gender was not statistically significant ( p = 0.617). A decrease in bowel frequency was observed in 15.9% of those with functional constipation. There was no significant difference in the proportion of participants in the constipation group by age ( p = 0.112). Binomial logistic regression analysis indicated that only fat per 100 kcal positively correlated with functional constipation [odds ratio = 1.216, 95% confidence interval: 1.0476-1.412]. Functional constipation is common among children in preschool and early elementary school in urban areas of Japan. Parents should pay attention to constipation-related symptoms other than defecation frequency. A high-fat diet should be avoided to prevent functional constipation.

Antigenic and genetic analysis of H3N8 influenza viruses isolated from horses in Japan and Mongolia, and imported from Canada and Belgium during 2007-2010.

PubMed

Motoshima, Masayuki; Okamatsu, Masatoshi; Asakura, Shingo; Kuribayashi, Saya; Sengee, Sugar; Batchuluun, Damdinjav; Ito, Mika; Maeda, Yukiko; Eto, Mariko; Sakoda, Yoshihiro; Sodnomdarjaa, Ruuragchaa; Kida, Hiroshi

2011-08-01

A/equine/Kanazawa/1/2007 (H3N8), A/equine/Hokkaido/I828/2008 (H3N8) and A/equine/Mongolia/1/2008 (H3N8) were isolated from infected horses. A/equine/Yokohama/aq19/2009 (H3N8) and A/equine/Yokohama/aq13/2010 (H3N8) were isolated from horses imported from Canada and Belgium examined at the Animal Quarantine Service in Yokohama, Japan. In the present study, these five isolates were genetically and antigenically analyzed. Phylogenetic analysis of hemagglutinin (HA) and neuraminidase (NA) genes showed that three isolates from horses in Japan and imported from Canada belonged to the same branch, clade 1 of the Florida sublineage, while the isolates from horses in Mongolia and imported from Belgium belonged to another branch, clade 2 of the Florida sublineage. Reactivity patterns of a panel of monoclonal antibodies to the HA of A/equine/Kanazawa/1/2007 (H3N8) with the five isolates indicate that the HAs of these viruses were antigenically similar to each other and to the reference strains A/equine/La Plata/1/1993 (H3N8) and A/equine/Avesta/1/1993 (H3N8). The present findings indicate that extensive antigenic variation has not accumulated among H3N8 influenza viruses in horses.

22 CFR 41.23 - Accredited officials in transit.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Accredited officials in transit. 41.23 Section 41.23 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF NONIMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Foreign Government Officials § 41.23 Accredited officials in...

22 CFR 41.23 - Accredited officials in transit.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Accredited officials in transit. 41.23 Section 41.23 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF NONIMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Foreign Government Officials § 41.23 Accredited officials in...

22 CFR 41.23 - Accredited officials in transit.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Accredited officials in transit. 41.23 Section 41.23 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF NONIMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Foreign Government Officials § 41.23 Accredited officials in...

22 CFR 41.23 - Accredited officials in transit.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Accredited officials in transit. 41.23 Section 41.23 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF NONIMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Foreign Government Officials § 41.23 Accredited officials in...

22 CFR 41.23 - Accredited officials in transit.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Accredited officials in transit. 41.23 Section 41.23 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF NONIMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Foreign Government Officials § 41.23 Accredited officials in...

22 CFR 2.3 - Notification of foreign officials.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Notification of foreign officials. 2.3 Section....C. 1116(b)(2), 1116(c)(4); sec. 4 of the Act of May 26, 1949, as amended (22 U.S.C. 2658)) [37 FR 24818, Nov. 22, 1972] ...

Expedition 22 Change of Command in the U.S. Laboratory

NASA Image and Video Library

2010-03-17

ISS022-E-100383 (17 March 2010) --- Crew members aboard the International Space Station are pictured in the Destiny laboratory during the ceremony of Changing-of-Command from Expedition 22 to Expedition 23. Pictured are NASA astronauts Jeffrey Williams (right, holding microphone), Expedition 22 commander; and T.J. Creamer (second right), Expedition 22/23 flight engineer; Russian cosmonauts Oleg Kotov (left), Expedition 22 flight engineer and Expedition 23 commander; and Maxim Suraev (mostly obscured at left background), Expedition 22 flight engineer; along with Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, Expedition 22/23 flight engineer.

Expedition 22 Change of Command in the U.S. Laboratory

NASA Image and Video Library

2010-03-17

ISS022-E-100363 (17 March 2010) --- Crew members aboard the International Space Station are pictured in the Destiny laboratory during the ceremony of Changing-of-Command from Expedition 22 to Expedition 23. Pictured are NASA astronauts Jeffrey Williams (right, holding microphone), Expedition 22 commander; and T.J. Creamer (center background), Expedition 22/23 flight engineer; Russian cosmonauts Oleg Kotov (left), Expedition 22 flight engineer and Expedition 23 commander; and Maxim Suraev (bottom), Expedition 22 flight engineer; along with Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi (mostly out of frame at right), Expedition 22/23 flight engineer.

Looking northeast over Piers 22 and 23 toward Mare Island ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Looking northeast over Piers 22 and 23 toward Mare Island Strait and the City of Vallejo - Mare Island Naval Shipyard, Finger Piers 22 & 23, Railroad Avenue near Eighteenth Street, Vallejo, Solano County, CA

16 CFR 23.22 - Disclosure of treatments to gemstones.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Disclosure of treatments to gemstones. 23.22... JEWELRY, PRECIOUS METALS, AND PEWTER INDUSTRIES § 23.22 Disclosure of treatments to gemstones. It is unfair or deceptive to fail to disclose that a gemstone has been treated if: (a) The treatment is not...

22 CFR 23.4 - Representative value in exchange.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Representative value in exchange. 23.4 Section 23.4 Foreign Relations DEPARTMENT OF STATE FEES AND FUNDS FINANCE AND ACCOUNTING § 23.4 Representative value in exchange. Representative value in exchange for the collection of a fee means foreign...

Complete Genomic Sequences of H3N8 Equine Influenza Virus Strains Used as Vaccine Strains in Japan

PubMed Central

Yamanaka, Takashi; Bannai, Hiroshi; Tsujimura, Koji; Kokado, Hiroshi

2018-01-01

ABSTRACT We sequenced the eight segments of influenza A virus strains A/equine/Ibaraki/1/2007 and A/equine/Yokohama/aq13/2010, which are strains of the Florida sublineage clades 1 and 2 of the H3N8 subtype equine influenza virus. These strains have been used as vaccine strains in Japan since 2016 in accordance with World Organization for Animal Health (OIE) recommendations. PMID:29567739

Complete Genomic Sequences of H3N8 Equine Influenza Virus Strains Used as Vaccine Strains in Japan.

PubMed

Nemoto, Manabu; Yamanaka, Takashi; Bannai, Hiroshi; Tsujimura, Koji; Kokado, Hiroshi

2018-03-22

We sequenced the eight segments of influenza A virus strains A/equine/Ibaraki/1/2007 and A/equine/Yokohama/aq13/2010, which are strains of the Florida sublineage clades 1 and 2 of the H3N8 subtype equine influenza virus. These strains have been used as vaccine strains in Japan since 2016 in accordance with World Organization for Animal Health (OIE) recommendations. Copyright © 2018 Nemoto et al.

NMR and X-ray studies of isomeric 22,23-dihydroxy stigmastanes

NASA Astrophysics Data System (ADS)

Khripach, Vladimir A.; Zhabinskii, Vladimir N.; Ivanova, Galina V.; Fando, Galina P.; Tsavlovskii, Dmitrii V.; Khripach, Natalya B.; Lyakhov, Alexander S.; Misharin, Alexander Yu.

2010-06-01

A comparative conformational study of steroidal side chain of (22 R,23 R)- and (22 S,23 S)-dihydroxy stigmastane derivatives was performed using single crystal X-ray diffraction and NMR spectroscopy. The preferred conformation in solution was shown to be close to that in the crystal. (22 R,23 R)-Isomers typical for natural plant steroid hormones brassinosteroids adopt a conformation in which both hydroxyl groups are pointed toward unhindered α-side of the steroidal plane and can thus participate in biochemical processes. Unnatural (22 S,23 S)-counterparts exhibit a conformation with the two hydroxyl groups oriented in the opposite direction and sterically hindered by 21-methyl group and terminal side chain fragment.

22 CFR 228.23 - Eligibility of marine insurance.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Eligibility of marine insurance. 228.23 Section 228.23 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT RULES ON SOURCE, ORIGIN AND NATIONALITY FOR COMMODITIES AND SERVICES FINANCED BY USAID Conditions Governing the Eligibility of Commodity...

22 CFR 228.23 - Eligibility of marine insurance.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Eligibility of marine insurance. 228.23 Section...-Related Services for USAID Financing § 228.23 Eligibility of marine insurance. The eligibility of marine... a cooperating country discriminates against marine insurance companies authorized to do business in...

28 CFR 22.23 - Privacy certification.

Code of Federal Regulations, 2010 CFR

2010-07-01

... STATISTICAL INFORMATION § 22.23 Privacy certification. (a) Each applicant for BJA, OJJDP, BJS, NIJ, or OJP... approval of a grant application or contract proposal which has a research or statistical project component... revealed for research or statistical purposes and that compliance with requests for information is not...

Stellar reaction rate for {sup 22}Mg+p->{sup 23}Al from the asymptotic normalization coefficient in the mirror nuclear system {sup 22}Ne+n->{sup 23}Ne

DOE Office of Scientific and Technical Information (OSTI.GOV)

Al-Abdullah, T.; Physics Department, Hashemite University, Zarqa 13115; Carstoiu, F.

2010-03-15

The production of {sup 22}Na in ONe novae can be influenced by the {sup 22}Mg(p,gamma){sup 23}Al reaction. To investigate this reaction rate at stellar energies, we have determined the asymptotic normalization coefficient (ANC) for {sup 22}Mg+p->{sup 23}Al through measurements of the ANCs in the mirror nuclear system {sup 22}Ne+n->{sup 23}Ne. The peripheral neutron-transfer reactions {sup 13}C({sup 12}C,{sup 13}C){sup 12}C and {sup 13}C({sup 22}Ne,{sup 23}Ne){sup 12}C were studied. The identical entrance and exit channels of the first reaction make it possible to extract independently the ground-state ANC in {sup 13}C. Our experiment gives C{sub p{sub 1/2}}{sup 2}({sup 13}C)=2.24+-0.11 fm{sup -1}, whichmore » agrees with the value obtained from several previous measurements. The weighted average for all the obtained C{sub p{sub 1/2}}{sup 2} is 2.31+-0.08 fm{sup -1}. This value is adopted to be used in obtaining the ANCs in {sup 23}Ne. The differential cross sections for the reaction {sup 13}C({sup 22}Ne,{sup 23}Ne){sup 12}C leading to the J{sup {pi}}=5/2{sup +} and 1/2{sup +} states in {sup 23}Ne have been measured at 12 MeV/u. Optical model parameters for use in the DWBA calculations were obtained from measurements of the elastic scatterings {sup 22}Ne+{sup 13}C and {sup 22}Ne+{sup 12}C. The extracted ANC for the ground state in {sup 23}Ne, C{sub d{sub 5/2}}{sup 2}=0.86+-0.08+-0.12 fm{sup -1}, is converted to its corresponding value in {sup 23}Al using mirror symmetry to give C{sub d{sub 5/2}}{sup 2}({sup 23}Al)=(4.63+-0.77)x10{sup 3} fm{sup -1}. The astrophysical S factor S(0) for the {sup 22}Mg(p,gamma) reaction was determined to be 0.96+-0.11 keV b. The consequences for nuclear astrophysics are discussed.« less

22 CFR 72.23 - Affidavit of next of kin.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Affidavit of next of kin. 72.23 Section 72.23 Foreign Relations DEPARTMENT OF STATE PROTECTION AND WELFARE OF AMERICANS, THEIR PROPERTY AND ESTATES DEATHS AND ESTATES Personal Estates of Deceased United States Citizens and Nationals § 72.23 Affidavit of...

22 CFR 123.23 - Monetary value of shipments.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Monetary value of shipments. 123.23 Section 123... EXPORT OF DEFENSE ARTICLES § 123.23 Monetary value of shipments. Port Directors of U.S. Customs and... value of the export does not exceed the aggregate monetary value (not quantity) stated on the license by...

Glucose 6-phosphate dehydrogenase variants in Japan.

PubMed

Miwa, S

1980-01-01

Fifty-four cases of glucose 6-phosphate dehydrogenase (G6PD) deficiency have so far been reported in Japan. Among them, 21 G6PD variants have been characterized. Nineteen out of the 21 variants were characterized in our laboratory and G6PD Heian and "Kyoto" by others. G6PD Tokyo, Tokushima, Ogikubo, Kurume, Fukushima, Yokohama, Yamaguchi, Wakayama, Akita, Heian and "Kyoto" were classified as Class 1, because all these cases showed chronic hemolytic anemia and severe enzyme deficiency. All these variants showed thermal instability. G6PD Mediterranean-like, Ogori, Gifu and Fukuoka were classified as Class 2, whereas G6PD Hofu, B(-) Chinese, Ube, Konan, Kamiube and Kiwa belonged to Class 3. All the 6 Class 3 variants were found as the results of the screening tests. The incidence of the deficiency in Japanese seems to be 0.1-0.5% but that of the cases which may slow drug-induced hemolysis would be much less. G6PD Ube and Konan appear to be relatively common in Japan.

Synchrotron Spectral Curvature from 22 MHZ to 23 GHZ

NASA Technical Reports Server (NTRS)

Kogut, Alan J.

2012-01-01

We combine surveys of the radio sky at frequencies 22 MHz to 1.4 GHz with data from the ARCADE-2 instrument at frequencies 3 GHz to 10 GHz to characterize the frequency spectrum of diffuse synchrotron emission in the Galaxy. The radio spectrum steepens with frequency from 22 MHz to 10 GHz. The projected spectral index at 23 GHz derived from the low-frequency data agrees well with independent measurements using only data at frequencies 23 GHz and above. Comparing the spectral index at 23 GHz to the value from previously published analyses allows extension of the model to higher frequencies. The combined data are consistent with a power-law index beta = -2.64 +/-= 0.03 at 0.31 GHz, steepening by an amount of Delta-beta = 0.07 every octave in frequency. Comparison of the radio data to models including the cosmic-ray energy spectrum suggests that any break in the synchrotron spectrum must occur at frequencies above 23 GHz.

22 CFR 42.23 - Certain former U.S. citizens.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Certain former U.S. citizens. 42.23 Section 42.23 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Immigrants Not Subject to Numerical Limitations of INA 201 and 202...

22 CFR 42.23 - Certain former U.S. citizens.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Certain former U.S. citizens. 42.23 Section 42.23 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Immigrants Not Subject to Numerical Limitations of INA 201 and 202...

22 CFR 42.23 - Certain former U.S. citizens.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Certain former U.S. citizens. 42.23 Section 42.23 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Immigrants Not Subject to Numerical Limitations of INA 201 and 202...

22 CFR 42.23 - Certain former U.S. citizens.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Certain former U.S. citizens. 42.23 Section 42.23 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Immigrants Not Subject to Numerical Limitations of INA 201 and 202...

22. Photocopy of October 23, 1926, photograph in San Francisco ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

22. Photocopy of October 23, 1926, photograph in San Francisco Call-Bulletin Library. UPPER PART OF FACADE DURING FIRE OF OCTOBER 23, 1926 - Mission Santa Clara de Asis, Franklin & Grant Streets, Santa Clara, Santa Clara County, CA

KENNEDY SPACE CENTER, FLA. - At Port Canaveral, the Pressurized Module of the Japanese Experiment Module (JEM) is lifted out of the ship’s cargo hold. The container transport ship carrying JEM departed May 2 from Yokohama Harbor in Japan for the voyage to the United States. The National Space Development Agency of Japan (NASDA) developed the laboratory at the Tsukuba Space Center near Tokyo. The Pressurized Module is the first element of the JEM, named "Kibo" (Hope), to be delivered to KSC. The JEM is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments. The JEM also includes an exposed facility (platform) for space environment experiments, a robotic manipulator system, and two logistics modules. The various JEM components will be assembled in space over the course of three Shuttle missions.

NASA Image and Video Library

2003-06-04

KENNEDY SPACE CENTER, FLA. - At Port Canaveral, the Pressurized Module of the Japanese Experiment Module (JEM) is lifted out of the ship’s cargo hold. The container transport ship carrying JEM departed May 2 from Yokohama Harbor in Japan for the voyage to the United States. The National Space Development Agency of Japan (NASDA) developed the laboratory at the Tsukuba Space Center near Tokyo. The Pressurized Module is the first element of the JEM, named "Kibo" (Hope), to be delivered to KSC. The JEM is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments. The JEM also includes an exposed facility (platform) for space environment experiments, a robotic manipulator system, and two logistics modules. The various JEM components will be assembled in space over the course of three Shuttle missions.

Korean Affairs Report No. 321

DTIC Science & Technology

1983-11-10

media recently reported articles on the occasion of the 38th anniversary of the founding of the Workers’ Party of Korea. The Peruvian paper UNLOAD...Central Committee of the Peruvian Communist Party. The paper stressed that the Workers’ Party of Korea was founded on 10 October 1945, but it had begun...and Shinichiro Kanemaki, general secretary, of the Music Council of Japan; the Yokohama Football Association of Japan; the Yokohama City Sports

Participatory conservation approaches for satoyama, the traditional forest and agricultural landscape of Japan.

PubMed

Kobori, Hiromi; Primack, Richard B

2003-06-01

The traditional agricultural landscape of Japan, known as satoyama, consists of a mixture of forests, wet rice paddy fields, grasslands, and villages. This landscape supports a great diversity of plant and animal species, many of which are significant to the Japanese culture. The satoyama landscape is currently being rapidly converted to residential and industrial uses in Japan's expanding metropolitan areas, with the local loss of many species. Only 7% of the land in the Yokohama area remains as satoyama. City residents and older farmers have become key participants in programs to protect examples of satoyama. Many urban residents value the experience of participating in agricultural and conservation activities once they are made aware of the threat faced by the satoyama landscape. In one particularly successful program, conservation efforts and fund-raising are linked to "Totoro", an imaginary forest animal featured in a popular animated film.

22 CFR 23.2 - Endorsing remittances for deposit in the Treasury.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Endorsing remittances for deposit in the Treasury. 23.2 Section 23.2 Foreign Relations DEPARTMENT OF STATE FEES AND FUNDS FINANCE AND ACCOUNTING § 23.2 Endorsing remittances for deposit in the Treasury. The Office of Finance—Cashier Unit, the...

Synthesis of ZSM-23/ZSM-22 intergrowth zeolite with a novel dual-template strategy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Bingchun, E-mail: wangbc@dicp.ac.cn; Graduate University of Chinese Academy of Sciences, Beijing 100049; Tian, Zhijian, E-mail: tianz@dicp.ac.cn

2009-12-15

ZSM-23/ZSM-22 intergrowth zeolite with fixed proportion of 60%ZSM-23/40%ZSM-22 has been synthesized with a novel dual-template strategy. The products were characterized by X-ray diffraction and scanning electron microscopy. Dimethylamine and diethylamine were used together as a dual-template system. The molar ratio of diethylamine to dimethylamine, which was changed with the type of aluminum source, was the key factor for the synthesis of intergrowth zeolites. A molar ratio of diethylamine to dimethylamine of 1:24 could result in an ZSM-23/ZSM-22 intergrowth zeolite if aluminum sulfate was used as aluminum source, whereas a molar ratio of diethylamine to dimethylamine of 1:12 was required tomore » get an ZSM-23/ZSM-22 intergrowth zeolite if sodium metaaluminate was used. Furthermore, fluoride anion could be involved in the process as a crystallization promoter.« less

22 CFR 201.23 - Procurement under private sector procedures.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Procurement under private sector procedures... § 201.23 Procurement under private sector procedures. (a) General requirements. Procurements under private sector procedures will normally be carried out by importers using negotiated procurement...

The Mexican expedition to observe the 8 December 1874 transit of Venus in Japan

NASA Astrophysics Data System (ADS)

Allen, Christine

2005-04-01

The voyage of the Mexican commission to observe the transit of Venus on 8 December 1874 in Japan is briefly recounted. The five-man expedition was led by Francisco Díaz Covarrubias. They succeeded in establishing two observing stations near Yokohama, one in Nogue-no-Yama and one on a hill called "The Bluff", and also in determining precise geographical positions for them. Clear skies allowed the observation of the transit at both stations. The results were presented in Paris in 1875, and published on the same year. They were meant as a contribution to be processed along with all other data obtained by different missions. The importance of the expedition for the development of early modern science in Mexico - particularly astronomy - is examined in the broad context of the social and political conditions then prevailing in the country. The relevance of the mission for the establishment of scientific, cultural and even commercial ties between Japan and Mexico is emphasized.

22 CFR 23.1 - Remittances made payable to the Department of State.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Remittances made payable to the Department of State. 23.1 Section 23.1 Foreign Relations DEPARTMENT OF STATE FEES AND FUNDS FINANCE AND ACCOUNTING § 23.1 Remittances made payable to the Department of State. Except as otherwise specified in this title...

TOP500 Supercomputers for November 2003

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strohmaier, Erich; Meuer, Hans W.; Dongarra, Jack

2003-11-16

22nd Edition of TOP500 List of World s Fastest Supercomputers Released MANNHEIM, Germany; KNOXVILLE, Tenn.; BERKELEY, Calif. In what has become a much-anticipated event in the world of high-performance computing, the 22nd edition of the TOP500 list of the worlds fastest supercomputers was released today (November 16, 2003). The Earth Simulator supercomputer retains the number one position with its Linpack benchmark performance of 35.86 Tflop/s (''teraflops'' or trillions of calculations per second). It was built by NEC and installed last year at the Earth Simulator Center in Yokohama, Japan.

PM2.5-induced airway inflammation and hyperresponsiveness in NC/Nga mice.

PubMed

Ogino, Keiki; Nagaoka, Kenjiro; Okuda, Tomoaki; Oka, Akira; Kubo, Masayuki; Eguchi, Eri; Fujikura, Yoshihisa

2017-03-01

The allergic inflammatory effects of particulate matter (PM) 2.5, collected with the cyclone system in Yokohama city in Japan, were investigated in NC/Nga mice, which are hypersensitive to mite allergens. PM2.5 with alum was injected intraperitoneally for sensitization. Five days later, 200 μg of PM2.5 in 25 μL of saline was administered to mice intranasally five times for further sensitization. On the 11th day, PM2.5 was administered as a challenge. On the 12th day, mice were examined for airway hyperresponsiveness (AHR), the bronchoalveolar lavage fluid (BALF) cell count, mRNA expression of Th 1 , Th 2 cytokines, and metallothioneins in lung tissue, and histopathology. PM2.5 increased AHR, total cell numbers including eosinophils in BALF, and mRNA levels of IL-5, IL-22, eotaxin, eotaxin 2, and metallothionein 3. In PM2.5-induced lungs, inflammation was observed around the bronchus. These results demonstrate that PM2.5 alone, collected with the cyclone system in Yokohama city in Japan, induces asthma-like airway inflammation. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1047-1054, 2017. © 2016 Wiley Periodicals, Inc.

Interleukin-23 (IL-23), independent of IL-17 and IL-22, drives neutrophil recruitment and innate inflammation during Clostridium difficile colitis in mice.

PubMed

McDermott, Andrew J; Falkowski, Nicole R; McDonald, Roderick A; Pandit, Chinmay R; Young, Vincent B; Huffnagle, Gary B

2016-01-01

Our objective was to determine the role of the inflammatory cytokine interleukin-23 (IL-23) in promoting neutrophil recruitment, inflammatory cytokine expression and intestinal histopathology in response to Clostridium difficile infection. Wild-type (WT) and p19(-/-) (IL-23KO) mice were pre-treated with cefoperazone in their drinking water for 5 days, and after a 2-day recovery period were challenged with spores from C. difficile strain VPI 10463. Interleukin-23 deficiency was associated with significant defects in both the recruitment of CD11b(High) Ly6G(H) (igh) neutrophils to the colon and the expression of neutrophil chemoattractants and stabilization factors including Cxcl1, Cxcl2, Ccl3 and Csf3 within the colonic mucosa as compared with WT animals. Furthermore, the expression of inflammatory cytokines including Il33, Tnf and Il6 was significantly reduced in IL-23-deficient animals. There was also a trend towards less severe colonic histopathology in the absence of IL-23. The induction of Il17a and Il22 was also significantly abrogated in IL-23KO mice. Inflammatory cytokine expression and neutrophilic inflammation were not reduced in IL-17a-deficient mice or in mice treated with anti-IL-22 depleting monoclonal antibody. However, induction of RegIIIg was significantly reduced in animals treated with anti-IL-22 antibody. Taken together, these data indicate that IL-23, but not IL-17a or IL-22, promotes neutrophil recruitment and inflammatory cytokine and chemokine expression in the colon in response to C. difficile infection. © 2015 John Wiley & Sons Ltd.

HFC-23 (CHF3) emission trend response to HCFC-22 (CHClF2) production and recent HFC-23 emission abatement measures

NASA Astrophysics Data System (ADS)

Miller, B. R.; Rigby, M.; Kuijpers, L. J. M.; Krummel, P. B.; Steele, L. P.; Leist, M.; Fraser, P. J.; McCulloch, A.; Harth, C.; Salameh, P.; Mühle, J.; Weiss, R. F.; Prinn, R. G.; Wang, R. H. J.; O'Doherty, S.; Greally, B. R.; Simmonds, P. G.

2010-08-01

HFC-23 (also known as CHF3, fluoroform or trifluoromethane) is a potent greenhouse gas (GHG), with a global warming potential (GWP) of 14 800 for a 100-year time horizon. It is an unavoidable by-product of HCFC-22 (CHClF2, chlorodifluoromethane) production. HCFC-22, an ozone depleting substance (ODS), is used extensively in commercial refrigeration and air conditioning, in the extruded polystyrene (XPS) foam industries (dispersive applications) and also as a feedstock in fluoropolymer manufacture (a non-dispersive use). Aside from small markets in specialty uses, HFC-23 has historically been considered a waste gas that was, and often still is, simply vented to the atmosphere. Efforts have been made in the past two decades to reduce HFC-23 emissions, including destruction (incineration) in facilities in developing countries under the United Nations Framework Convention on Climate Change's (UNFCCC) Clean Development Mechanism (CDM), and by process optimization and/or voluntary incineration by most producers in developed countries. We present observations of lower-tropospheric mole fractions of HFC-23 measured by "Medusa" GC/MSD instruments from ambient air sampled in situ at the Advanced Global Atmospheric Gases Experiment (AGAGE) network of five remote sites (2007-2009) and in Cape Grim air archive (CGAA) samples (1978-2009) from Tasmania, Australia. These observations are used with the AGAGE 2-D atmospheric 12-box model and an inverse method to produce model mole fractions and a "top-down" HFC-23 emission history. The model 2009 annual mean global lower-tropospheric background abundance is 22.6 (±0.2) pmol mol-1. The derived HFC-23 emissions show a "plateau" during 1997-2003, followed by a rapid ~50% increase to a peak of 15.0 (+1.3/-1.2) Gg/yr in 2006. Following this peak, emissions of HFC-23 declined rapidly to 8.6 (+0.9/-1.0) Gg/yr in 2009, the lowest annual emission of the past 15 years. We derive a 1990-2008 "bottom-up" HFC-23 emission history using data from

HFC-23 (CHF3) emission trend response to HCFC-22 (CHClF2) production and recent HFC-23 emission abatement measures

NASA Astrophysics Data System (ADS)

Miller, B. R.; Rigby, M.; Kuijpers, L. J. M.; Krummel, P. B.; Steele, L. P.; Leist, M.; Fraser, P. J.; McCulloch, A.; Harth, C.; Salameh, P.; Mühle, J.; Weiss, R. F.; Prinn, R. G.; Wang, R. H. J.; O'Doherty, S.; Greally, B. R.; Simmonds, P. G.

2010-05-01

HFC-23 (also known as CHF3, fluoroform or trifluoromethane) is a potent greenhouse gas (GHG), with a global warming potential (GWP) of 14 800 for a 100-year time horizon. It is an unavoidable by-product of HCFC-22 (CHClF2, chlorodifluoromethane) production. HCFC-22, an ozone depleting substance (ODS), is used extensively in commercial refrigeration and air conditioning, in the extruded polystyrene (XPS) foam industries (dispersive applications) and also as a feedstock in fluoropolymer manufacture (a non-dispersive use). Aside from small markets in specialty uses, HFC-23 has historically been considered a waste gas that was, and often still is, simply vented to the atmosphere. Efforts have been made in the past two decades to reduce HFC-23 emissions, including destruction (incineration) in facilities in developing countries under the United Nations Framework Convention on Climate Change's (UNFCCC) Clean Development Mechanism (CDM), and by process optimization and/or voluntary incineration by most producers in developed countries. We present observations of lower-tropospheric mole fractions of HFC-23 measured by "Medusa" GC/MSD instruments from ambient air sampled in situ at the Advanced Global Atmospheric Gases Experiment (AGAGE) network of five remote sites and in Cape Grim air archive (CGAA) samples (1978-2009) from Tasmania, Australia. These observations are used with the AGAGE 2-D atmospheric 12-box model and an inverse method to produce model mole fractions and a "top-down" HFC-23 emission history. The model 2009 annual mean global lower-tropospheric background abundance is 22.8 (±0.2) pmol mol-1. The derived HFC-23 emissions show a "plateau" during 1997-2003, followed by a rapid ~50% increase to a peak of 15.0 (+1.3/-1.2) Gg/yr in 2006. Following this peak, emissions of HFC-23 declined rapidly to 8.6 (+0.9/-1.0) Gg/yr in 2009, the lowest annual emission of the past 15 years. We derive a 1990-2008 "bottom-up" HFC-23 emission history using data from the United

Biodiversity data mining from Argus-eyed citizens: the first illegal introduction record of Lepomis macrochirus macrochirus Rafinesque, 1819 in Japan based on Twitter information.

PubMed

Miyazaki, Yusuke; Teramura, Akinori; Senou, Hiroshi

2016-01-01

An apparent illegal introduction of Lepomis macrochirus macrochirus from Yokohama City, Kanagawa Prefecture, Japan, is reported based on a juvenile specimen and a photograph of two adults collected on 14 June 2015 and deposited in the Kangawa Prefectural Museum of Natural History. The specimens and photographs were initially reported on the internet-based social networking site, Twitter. Two specimens of Carassius auratus, including an aquarium form, were also reported at the same locality and date, suggesting that the illegal introductions originated from an aquarium release. Our report demonstrates an example of web data mining in the discipline of Citizen Science.

75 FR 42444 - Federal Open Market Committee; Domestic Policy Directive of June 22 and 23, 2010

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-21

... FEDERAL RESERVE SYSTEM Federal Open Market Committee; Domestic Policy Directive of June 22 and 23...), there is set forth below the domestic policy directive issued by the Federal Open Market Committee at... Committee at its meeting held on June 22 and 23, 2010, which includes the domestic policy directive issued...

KENNEDY SPACE CENTER, FLA. - At Port Canaveral, the Pressurized Module of the Japanese Experiment Module (JEM) is lifted out of the ship’s cargo hold. It will be loaded onto the truck bed in the background for transfer to KSC’s Space Station Processing Facility. The container transport ship carrying JEM departed May 2 from Yokohama Harbor in Japan for the voyage to the United States. The National Space Development Agency of Japan (NASDA) developed the laboratory at the Tsukuba Space Center near Tokyo. The Pressurized Module is the first element of the JEM, named "Kibo" (Hope), to be delivered to KSC. The JEM is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments. The JEM also includes an exposed facility (platform) for space environment experiments, a robotic manipulator system, and two logistics modules. The various JEM components will be assembled in space over the course of three Shuttle missions.

NASA Image and Video Library

2003-06-04

KENNEDY SPACE CENTER, FLA. - At Port Canaveral, the Pressurized Module of the Japanese Experiment Module (JEM) is lifted out of the ship’s cargo hold. It will be loaded onto the truck bed in the background for transfer to KSC’s Space Station Processing Facility. The container transport ship carrying JEM departed May 2 from Yokohama Harbor in Japan for the voyage to the United States. The National Space Development Agency of Japan (NASDA) developed the laboratory at the Tsukuba Space Center near Tokyo. The Pressurized Module is the first element of the JEM, named "Kibo" (Hope), to be delivered to KSC. The JEM is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments. The JEM also includes an exposed facility (platform) for space environment experiments, a robotic manipulator system, and two logistics modules. The various JEM components will be assembled in space over the course of three Shuttle missions.

Vortex Simulation of Turbulent Combustion

DTIC Science & Technology

1990-10-01

14. Nissan Motor Company Research Center, Yokoska, Japan, April 1990. 15. Mitsubishi Heavy Industries, Yokohama, Japan, April 1990. 16. Mazda Motor ...University of Rome Workshop on Fluid Mechanics of Combustion, June 1989. 2. Brown University, October 1989. 3. Ford Motor Company, Meeting on Flow...Computational Fluid Dynamics, Tokyo, Japan, April 1990. 12. Honda Motor Company, Wako, Japan, April 1990. 13. Toyota Motor Company, Nagoya, Japan, April 1990

76 FR 70758 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Sematech, Inc. D...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-15

...; Toshiba Corporation, Yokohama, Japan; Panasonic Semiconductor Discrete Devices Co., Ltd., Kyoto, Japan... and admit program members that only join certain discrete projects and thus only have access to information and intellectual property created under the discrete projects that these lower-tiered members join...

Characterizing the effect of summer temperature on heatstroke-related emergency ambulance dispatches in the Kanto area of Japan.

PubMed

Ng, Chris Fook Sheng; Ueda, Kayo; Ono, Masaji; Nitta, Hiroshi; Takami, Akinori

2014-07-01

Despite rising concern on the impact of heat on human health, the risk of high summer temperature on heatstroke-related emergency dispatches is not well understood in Japan. A time-series study was conducted to examine the association between apparent temperature and daily heatstroke-related ambulance dispatches (HSAD) within the Kanto area of Japan. A total of 12,907 HSAD occurring from 2000 to 2009 in five major cities-Saitama, Chiba, Tokyo, Kawasaki, and Yokohama-were analyzed. Generalized additive models and zero-inflated Poisson regressions were used to estimate the effects of daily maximum three-hour apparent temperature (AT) on dispatch frequency from May to September, with adjustment for seasonality, long-term trend, weekends, and public holidays. Linear and non-linear exposure effects were considered. Effects on days when AT first exceeded its summer median were also investigated. City-specific estimates were combined using random effects meta-analyses. Exposure-response relationship was found to be fairly linear. Significant risk increase began from 21 °C with a combined relative risk (RR) of 1.22 (95% confidence interval, 1.03-1.44), increasing to 1.49 (1.42-1.57) at peak AT. When linear exposure was assumed, combined RR was 1.43 (1.37-1.50) per degree Celsius increment. Overall association was significant the first few times when median AT was initially exceeded in a particular warm season. More than two-thirds of these initial hot days were in June, implying the harmful effect of initial warming as the season changed. Risk increase that began early at the fairly mild perceived temperature implies the need for early precaution.

82 FR 35991 - Certain Flash Memory Devices and Components Thereof; Notice of Commission Determination Not To...

Federal Register 2010, 2011, 2012, 2013, 2014

2017-08-02

... following respondents: SanDisk LLC of Milpitas, California; Western Digital Corporation of Irvine, California; Western Digital Technologies, Inc. of Milpitas, California; SanDisk Limited of Yokohama, Japan...

IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization

PubMed Central

Yoon, Juhan; Oyoshi, Michiko K.; Hoff, Sabine; Chervonsky, Alexander; Oppenheim, Joost J.; Rosenstiel, Philip

2016-01-01

Atopic dermatitis (AD) is a Th2-dominated inflammatory skin disease characterized by epidermal thickening. Serum levels of IL-22, a cytokine known to induce keratinocyte proliferation, are elevated in AD, and Th22 cells infiltrate AD skin lesions. We show that application of antigen to mouse skin subjected to tape stripping, a surrogate for scratching, induces an IL-22 response that drives epidermal hyperplasia and keratinocyte proliferation in a mouse model of skin inflammation that shares many features of AD. DC-derived IL-23 is known to act on CD4+ T cells to induce IL-22 production. However, the mechanisms that drive IL-23 production by skin DCs in response to cutaneous sensitization are not well understood. We demonstrate that IL-23 released by keratinocytes in response to endogenous TLR4 ligands causes skin DCs, which selectively express IL-23R, to up-regulate their endogenous IL-23 production and drive an IL-22 response in naive CD4+ T cells that mediates epidermal thickening. We also show that IL-23 is released in human skin after scratching and polarizes human skin DCs to drive an IL-22 response, supporting the utility of IL-23 and IL-22 blockade in AD. PMID:27551155

75 FR 54914 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-LiMo Foundation

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-09

... damages under specified circumstances. Specifically, SRS Labs, Santa Ana, CA; Smart Communications, Inc., Makati City, Republic of the Philippines; NTT Data MSE Corporation, Yokohama, Japan; STEricsson AB, Lund...

Proton threshold states in the Na22(p,γ)Mg23 reaction and astrophysical implications

NASA Astrophysics Data System (ADS)

Comisel, H.; Hategan, C.; Graw, G.; Wolter, H. H.

2007-04-01

Proton threshold states in Mg23 are important for the astrophysically relevant proton capture reaction Na22(p,γ)Mg23. In the indirect determination of the resonance strength of the lowest states, which were not accessible by direct methods, some of the spin-parity-assignments remained experimentally uncertain. We have investigated these states with shell model, Coulomb displacement, and Thomas-Ehrman shift calculations. From the comparison of calculated and observed properties, we relate the lowest relevant resonance state at Ex=7643 keV to an excited 3/2+ state in accordance with a recent experimental determination by Jenkins From this we deduce significantly improved values for the Na22(p,γ)Mg23 reaction rate at stellar temperatures below T9=0.1 K.

Frequent loss of heterozygosity in two distinct regions, 8p23.1 and 8p22, in hepatocellular carcinoma

PubMed Central

Lu, Tomoe; Hano, Hiroshi; Meng, Chenxi; Nagatsuma, Keisuke; Chiba, Satoru; Ikegami, Masahiro

2007-01-01

AIM: To identify the precise location of putative tumor suppressor genes (TSGs) on the short arm of chromosome 8 in patients with hepatocellular carcinoma (HCC). METHODS: We used 16 microsatellite markers informative in Japanese patients, which were selected from 61 published markers, on 8p, to analyze the frequency of loss of heterozygosity (LOH) in each region in 33 cases (56 lesions) of HCC. RESULTS: The frequency of LOH at 8p23.2-21 with at least one marker was 63% (20/32) in the informative cases. More specifically, the frequency of LOH at 8p23.2, 8p23.1, 8p22, and 8p21 was 6%, 52%, 47%, and 13% in HCC cases. The LOH was significantly more frequent at 8p23.1 and 8p22 than the average (52% vs 22%, P = 0.0008; and 47% vs 22%, P = 0.004, respectively) or others sites, such as 8p23.2 (52% vs 6%, P = 0.003; 47% vs 22%, P = 0.004) and 8p21 (52% vs 13%, P = 0.001; 47% vs 13%, P = 0.005) in liver cancer on the basis of cases. Notably, LOH frequency was significantly higher at D8S277, D8S503, D8S1130, D8S552, D8S254 and D8S258 than at the other sites. However, no allelic loss was detected at any marker on 8p in the lesions of nontumor liver tissues. CONCLUSION: Deletion of 8p, especially the loss of 8p23.1-22, is an important event in the initiation or promotion of HCC. Our results should be useful in identifying critical genes that might lie at 8p23.1-22. PMID:17373745

22 CFR 221.23 - Payment to A.I.D. of excess amounts received by a Noteholder.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Payment to A.I.D. of excess amounts received by a Noteholder. 221.23 Section 221.23 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Procedure for Obtaining Compensation § 221.23 Payment to A...

22 CFR 221.23 - Payment to A.I.D. of excess amounts received by a Noteholder.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Payment to A.I.D. of excess amounts received by a Noteholder. 221.23 Section 221.23 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Procedure for Obtaining Compensation § 221.23 Payment to A...

22 CFR 221.23 - Payment to A.I.D. of excess amounts received by a Noteholder.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Payment to A.I.D. of excess amounts received by a Noteholder. 221.23 Section 221.23 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Procedure for Obtaining Compensation § 221.23 Payment to A...

22 CFR 221.23 - Payment to A.I.D. of excess amounts received by a Noteholder.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Payment to A.I.D. of excess amounts received by a Noteholder. 221.23 Section 221.23 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Procedure for Obtaining Compensation § 221.23 Payment to A...

22 CFR 221.23 - Payment to A.I.D. of excess amounts received by a Noteholder.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Payment to A.I.D. of excess amounts received by a Noteholder. 221.23 Section 221.23 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Procedure for Obtaining Compensation § 221.23 Payment to A...

Proton-decay spectroscopic studies of the exotic nuclides aluminum-23, silicon-23, aluminum-22 and rubidium-77

NASA Astrophysics Data System (ADS)

Rowe, Michael William

Aluminum-23 was produced by 40 MeV 3He2+ bombardments of Mg targets in four experiments at the LBNL 88' ' Cyclotron. Reaction products were transported via helium-jet to a detection chamber where they were counted using two low-energy particle-identification (PI) telescopes. New proton groups were observed with laboratory energies (and intensities relative to the known peak at 838 +/- 5 keV) of 246 20 (33 +/- 3%) and 556 +/- 5 keV (68 +/- 5%), respectively. Several possible decay assignments are discussed for the former group. The possibility that it originates from the decay through the isobaric analog state (IAS) and corresponding implications for isospin mixing and the proton-capture resonance strength are discussed. The Gamow-Teller strength function has been deduced from these and several weaker proton transitions; the results are compared with theoretical predictions. Silicon-23 and 22Al were produced in a 110 MeV 3He2+ bombardment of a 24Mg target; reaction products were transported via helium jet and observed by two PI telescopes with proton sensitivity from 0-35-12.5 MeV. Three weak proton peaks at 7673 +/- 33, 9642 +/- 57 and 10861 +/- 68 keV have been tentatively assigned to the beta-delayed proton decay of 23Si through its IAS. From these results, the estimated 23Si mass excess is 23.25 +/- 0.05 MeV. Beta-delayed two-proton sum peaks were observed at 4478 +/- 15 and 6111 +/- 15 keV (c.m.), in agreement with earlier work an the decay of 22Al at wide relative-emission angles. The energies of several weaker two-proton sum peaks were compared with predicted and experimental values for the β-2p decay of 23Si. A search for proton emission from a predicted 19/2- isomer of 77Rb has been performed in three bombardments of Ca targets by 40Ca beams at energies of 145,160 and 132 MeV. Products of the first two bombardments were transported via helium jet and observed by two PI telescopes. In the third bombardment, the mass separator RAMA transported mass-77

Proton-decay spectroscopic studies of the exotic nuclides aluminum-23, silicon-23, aluminum-22 and rubidium-77

NASA Astrophysics Data System (ADS)

Rowe, Michael William

1998-09-01

Aluminum-23 was produced by 40 MeV 3He2+ bombardments of Mg targets in four experiments at the LBNL 88' ' Cyclotron. Reaction products were transported via helium-jet to a detection chamber where they were counted using two low-energy particle-identification (PI) telescopes. New proton groups were observed with laboratory energies (and intensities relative to the known peak at 838 +/- 5 keV) of 246 20 (33 +/- 3%) and 556 +/- 5 keV (68 +/- 5%), respectively. Several possible decay assignments are discussed for the former group. The possibility that it originates from the decay through the isobaric analog state (IAS) and corresponding implications for isospin mixing and the proton-capture resonance strength are discussed. The Gamow-Teller strength function has been deduced from these and several weaker proton transitions; the results are compared with theoretical predictions. Silicon-23 and 22Al were produced in a 110 MeV 3He2+ bombardment of a 24Mg target; reaction products were transported via helium jet and observed by two PI telescopes with proton sensitivity from 0-35-12.5 MeV. Three weak proton peaks at 7673 +/- 33, 9642 +/- 57 and 10861 +/- 68 keV have been tentatively assigned to the beta-delayed proton decay of 23Si through its IAS. From these results, the estimated 23Si mass excess is 23.25 +/- 0.05 MeV. Beta-delayed two-proton sum peaks were observed at 4478 +/- 15 and 6111 +/- 15 keV (c.m.), in agreement with earlier work an the decay of 22Al at wide relative-emission angles. The energies of several weaker two-proton sum peaks were compared with predicted and experimental values for the β-2p decay of 23Si. A search for proton emission from a predicted 19/2- isomer of 77Rb has been performed in three bombardments of Ca targets by 40Ca beams at energies of 145,160 and 132 MeV. Products of the first two bombardments were transported via helium jet and observed by two PI telescopes. In the third bombardment, the mass separator RAMA transported mass-77

The study of Equatorial coronal hole during maximum phase of Solar Cycle 21, 22, 23 and 24

NASA Astrophysics Data System (ADS)

Karna, Mahendra; Karna, Nishu

2017-08-01

The 11-year Solar Cycle (SC) is characterized by the periodic change in the solar activity like sunspot numbers, coronal holes, active regions, eruptions such as flares and coronal mass ejections. We study the relationship between equatorial coronal holes (ECH) and the active regions (AR) as coronal whole positions and sizes change with the solar cycle. We made a detailed study of equatorial coronal hole for four solar maximum: Solar Cycle 21 (1979,1980,1981 and 1982), Solar Cycle 22 (1989, 1990, 1991 and 1992), Solar Cycle 23 (1999, 2000, 2001 and 2002) and Solar Cycle 24 (2012, 2013, 2014 and 2015). We used publically available NOAA solar coronal hole data for cycle 21 and 22. We measured the ECH region using the EIT and AIA synoptic map for cycle 23 and 24. We noted that in two complete 22-year cycle of solar activity, the equatorial coronal hole numbers in SC 22 is greater than SC 21 and similarly, SC 24 equatorial coronal hole numbers are greater than SC 23. Moreover, we also compared the position of AR and ECH during SC 23 and 24. We used daily Solar Region Summary (SRS) data from SWPC/NOAA website. Our goal is to examine the correlation between equatorial holes, active regions, and flares.

21 CFR 73.3117 - 16,23-Dihydrodinaphtho[2,3-a:2′,3′-i] naphth [2′,3′:6,7] indolo [2,3-c] carbazole-5,10,15,17,22...

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 1 2013-04-01 2013-04-01 false 16,23-Dihydrodinaphtho[2,3-a:2â²,3â²-i] naphth [2â²,3â²:6,7] indolo [2,3-c] carbazole-5,10,15,17,22,24-hexone. 73.3117 Section 73.3117 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR...

21 CFR 73.3117 - 16,23-Dihydrodinaphtho[2,3-a:2′,3′-i] naphth [2′,3′:6,7] indolo [2,3-c] carbazole-5,10,15,17,22...

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 1 2012-04-01 2012-04-01 false 16,23-Dihydrodinaphtho[2,3-a:2â²,3â²-i] naphth [2â²,3â²:6,7] indolo [2,3-c] carbazole-5,10,15,17,22,24-hexone. 73.3117 Section 73.3117 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR...

21 CFR 73.3117 - 16,23-Dihydrodinaphtho[2,3-a:2′,3′-i] naphth [2′,3′:6,7] indolo [2,3-c] carbazole-5,10,15,17,22...

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 1 2014-04-01 2014-04-01 false 16,23-Dihydrodinaphtho[2,3-a:2â²,3â²-i] naphth [2â²,3â²:6,7] indolo [2,3-c] carbazole-5,10,15,17,22,24-hexone. 73.3117 Section 73.3117 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR...

21 CFR 73.3117 - 16,23-Dihydrodinaphtho[2,3-a:2′,3′-i] naphth [2′,3′:6,7] indolo [2,3-c] carbazole-5,10,15,17,22...

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false 16,23-Dihydrodinaphtho[2,3-a:2â²,3â²-i] naphth [2â²,3â²:6,7] indolo [2,3-c] carbazole-5,10,15,17,22,24-hexone. 73.3117 Section 73.3117 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR...

21 CFR 73.3117 - 16,23-Dihydrodinaphtho[2,3-a:2′,3′-i] naphth [2′,3′:6,7] indolo [2,3-c] carbazole-5,10,15,17,22...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false 16,23-Dihydrodinaphtho[2,3-a:2â²,3â²-i] naphth [2â²,3â²:6,7] indolo [2,3-c] carbazole-5,10,15,17,22,24-hexone. 73.3117 Section 73.3117 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR...

Maternal effects and larval survival of marbled sole Pseudopleuronectes yokohamae

NASA Astrophysics Data System (ADS)

Higashitani, Tomomi; Takatsu, Tetsuya; Nakaya, Mitsuhiro; Joh, Mikimasa; Takahashi, Toyomi

2007-07-01

Maternal effects of animals are the phenotypic influences of age, size, and condition of spawners on the survival and phenotypic traits of offspring. To clarify the maternal effects for marbled sole Pseudopleuronectes yokohamae, we investigated the effects of body size, nutrient condition, and growth history of adult females on egg size, larval size, and starvation tolerance, growth, and feeding ability of offspring. The fecundity of adult females was strongly dependent on body size. Path analysis revealed that the mother's total length positively affected mean egg diameter, meaning that large females spawned large eggs. In contrast, the relative growth rate of adult females negatively affected egg diameter. Egg diameters positively affected both notochord length and yolk sac volume of the larvae at hatching. Under starvation conditions, notochord length at hatching strongly and positively affected days of survival at 14 °C but not at 9 °C. Under adequate food conditions (1000 rotifers L - 1 ), the notochord length of larvae 5 days after hatching positively affected feeding rate, implying that large larvae have high feeding ability. In addition, the mean growth rate of larvae between 0 and 15 days increased with increasing egg diameter under homogenous food conditions, suggesting that larvae hatched from large eggs might have a growth advantage for at least to 15 days after hatching. In marbled sole, these relationships (i.e., mother's body size-egg size-larval size-larval resistance to starvation-larval feeding ability) may help explain recruitment variability.

23. BUILDING NO. 22L, SHEET NO. 3. United Engineering Company ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

23. BUILDING NO. 22L, SHEET NO. 3. United Engineering Company Ltd., Alameda Shipyard, Ship Repair Facilities. Plans, section, & detail. Alben Froberg, Architect, 3454 Harlan Street, Oakland, California. Sheet no. 3. Plan no. 10,525. Various scales. March 1, 1943, last revised 3/15/43. U.S. Navy, Bureau of Yards & Docks, Contract no. bs 76. Approved for construction October 9, 1943. blueprint - United Engineering Company Shipyard, Engineering Building, 2900 Main Street, Alameda, Alameda County, CA

46 CFR 282.22 - Maintenance (upkeep) and repairs.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) (Percent) Japan Japan 85 36.21 30.78 U.S 15 0 0 100 30.78 23.4 7.20 Norway Norway 15 44.72 6.71 Netherlands 20 43.23 8.65 Japan 45 36.21 16.29 U.S 20 0 0 100 31.65 31.1 9.84 United Kingdom U.K 80 19.00 15.20...

Complete genome sequence of Leptospirillum ferrooxidans strain C2-3, isolated from a fresh volcanic ash deposit on the island of Miyake, Japan.

PubMed

Fujimura, Reiko; Sato, Yoshinori; Nishizawa, Tomoyasu; Oshima, Kenshiro; Kim, Seok-Won; Hattori, Masahira; Kamijo, Takashi; Ohta, Hiroyuki

2012-08-01

A diazotrophic, acidophilic, iron-oxidizing bacterium, Leptospirillum ferrooxidans, known to be difficult to cultivate, was isolated from a fresh volcanic ash deposit on the island of Miyake, Japan. Here, we report the complete genome sequence of a cultured strain, C2-3.

Overweight male personnel of the Japan Self-Defense Forces with body mass indices of 23.0-24.9 and obesity-related metabolic disorders.

PubMed

Sakuta, Hidenari; Suzuki, Takashi

2008-03-01

To assess the validity of the criterion of overweight for Asian people that is recommended by Western Pacific Region of the World Health Organization. We carried out a cross-sectional analysis of the association between the criterion of overweight for ethnic Asian people--body mass indices (BMI) of 23.0-24.9 kg/m(2)--and the presence of obesity-related metabolic disorders among middle-aged Japanese men (n = 974, age range 51-59). The odds ratios (95% confidence interval) of overweight to those with normal weight (BMI < 23.0 kg/m(2)) were 1.61 (1.11-2.33) for the presence of impaired glucose tolerance, 1.95 (1.30-2.93) for hypertension, 2.22 (1.63-3.03) for hypercholesterolemia, 2.83 (2.02-3.97) for hypertriglyceridemia, and 2.06 (1.06-4.00) for hyperuricemia. Overweight was not associated with the presence of type 2 diabetes or with high gamma-glutamyl transferase in the present study (odds ratios: 1.09 and 1.05, respectively). Adjustment for age, rank, and lifestyle factors affected the results only slightly. Based on these results, we conclude that the Asian criterion of overweight appears to be rational in terms of its association with obesity-related metabolic disorders in male personnel of the Japan Self-Defense Forces in their fifties.

Complete Genome Sequence of Leptospirillum ferrooxidans Strain C2-3, Isolated from a Fresh Volcanic Ash Deposit on the Island of Miyake, Japan

PubMed Central

Fujimura, Reiko; Sato, Yoshinori; Nishizawa, Tomoyasu; Oshima, Kenshiro; Kim, Seok-Won; Hattori, Masahira; Kamijo, Takashi

2012-01-01

A diazotrophic, acidophilic, iron-oxidizing bacterium, Leptospirillum ferrooxidans, known to be difficult to cultivate, was isolated from a fresh volcanic ash deposit on the island of Miyake, Japan. Here, we report the complete genome sequence of a cultured strain, C2-3. PMID:22815442

Renewable Energy Opportunities at the Kanto Installations, Japan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Solana, Amy E.; Horner, Jacob A.; Russo, Bryan J.

2010-09-24

This document provides an overview of renewable resource development potential at the U.S. Army installations in the Kanto region in Japan, which includes Camp Zama, Yokohama North Dock, Sagamihara Family Housing Area (SFHA), Sagami General Depot, and Akasaka Press Center. This effort focuses on grid-connected generation of electricity from renewable energy sources and also on ground source heat pumps for heating and cooling buildings. The effort was funded by the Huntsville Army Corps of Engineers, and includes the development of a methodology for renewable resource assessment at Army installations located on foreign soil. The methodology is documented in Renewable Energymore » Assessment Methodology for Japanese OCONUS Army Installations. The site visit to the Kanto installations took place on April 5 and 6, 2010. At the current time, there are some renewable technologies that show economic potential. Because of siting restrictions and the small size of these installations, development of most renewable energy technologies will likely be limited to Camp Zama. Project feasibility is based on installation-specific resource availability and energy costs and projections based on accepted life-cycle cost methods. Development of any renewable energy project will be challenging, as it will require investigation into existing contractual obligations, new contracts that could be developed, the legality of certain partnerships, and available financing avenues, which involves the U.S. Forces Japan (USFJ), the Government of Japan (GOJ), and a number of other parties on both sides. The Army will not be able to implement a project without involvement and approval from the other services and multiple levels of Japanese government. However, implementation of renewable energy projects could be an attractive method for GOJ to reduce greenhouse gas emissions and lower annual utility payments to USFJ. This report recommends projects to pursue and offers approaches to use. The most

22 CFR 213.23 - Salary offset when USAID is not the creditor agency.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Salary offset when USAID is not the creditor... Administrative Offset § 213.23 Salary offset when USAID is not the creditor agency. (a) USAID will use salary... installment, if a date other than the next established pay period. (b) Requests for salary offset must be sent...

Proton threshold states in the {sup 22}Na(p,{gamma}){sup 23}Mg reaction and astrophysical implications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Comisel, H.; Hategan, C.; Graw, G.

Proton threshold states in {sup 23}Mg are important for the astrophysically relevant proton capture reaction {sup 22}Na(p,{gamma}){sup 23}Mg. In the indirect determination of the resonance strength of the lowest states, which were not accessible by direct methods, some of the spin-parity-assignments remained experimentally uncertain. We have investigated these states with shell model, Coulomb displacement, and Thomas-Ehrman shift calculations. From the comparison of calculated and observed properties, we relate the lowest relevant resonance state at E{sub x}=7643 keV to an excited 3/2{sup +} state in accordance with a recent experimental determination by Jenkins et al. From this we deduce significantly improvedmore » values for the {sup 22}Na(p,{gamma}){sup 23}Mg reaction rate at stellar temperatures below T{sub 9}=0.1 K.« less

PATRAM '92: 10th international symposium on the packaging and transportation of radioactive materials [Papers presented by Sandia National Laboratories

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

This document provides the papers presented by Sandia Laboratories at PATRAM '92, the tenth International symposium on the Packaging and Transportation of Radioactive Materials held September 13--18, 1992 in Yokohama City, Japan. Individual papers have been cataloged separately. (FL)

Measuring relative work values for home care nursing services in Japan.

PubMed

Ogata, Yasuko; Kobayashi, Yasuki; Fukuda, Takashi; Mori, Katsumi; Hashimoto, Michio; Otosaka, Kayo

2004-01-01

Japan's system of Home Visit Nursing Care Stations (Station) began in 1991. To maintain the quality of services in home health nursing provided by Stations, reimbursement needs to account not only for the number of home visits, but also for the time and intensity of nursing services. This study aimed primarily to investigate the total work value and the three dimensions (time, mental effort, and physical effort) of actual visiting nursing services for the aged, and to quantify the contribution made by the three dimensions of nursing services to total work. The secondary purpose was to determine whether patient characteristics, nurse characteristics, and types of nursing services contributed to the variance in total work. Total work is defined as comprehensive work input of nursing services, with careful consideration given to both the intensity and duration of work. Self-report questionnaires about actual visiting nursing services, based on the Resource-Based Relative Value Scale, were answered by 32 nurses from three Stations in urban Yokohama, Japan. Regression analysis showed that time and intensity (physical effort and mental effort) explained 96% the variance in total work. Time alone accounted for only 39% of the variance in total work. Patient characteristics, nurse characteristics, and service type accounted for less variance in total work than did time and intensity. The study findings indicate that reimbursement of nursing services should reflect not only the time required for each visit, but also the intensity of nursing services provided, including mental effort and physical effort.

Characterization of proteins in the muscle of limanda yokohamae from the masan bay, Korea

NASA Astrophysics Data System (ADS)

Kim, Soo Woon; Kim, Sam Moon; Lee, Dong Kun; Moon, Hyo Bang; Choi, Hee Gu; Kang, Chang Keun; Choe, Eun Sang

2007-06-01

Increasing industrial development in the Masan Bay area of Korea over the past decades increased the risk for the survival of marine organisms in the bay area by the deterioration of the water quality. Since living organisms have the ability to adapt contamination-associated stimuli by the alteration of gene expression, changes in proteins can be used as an important criterion for assessing the levels of environmental conditions. In this study, therefore, alterations of the expression of proteins in the muscle of Limanda yokohamae from Dukdong and Dotsum in the bay area were surveyed and characterized as compared with Haegumgang, which served as a control site. The results demonstrated that the twenty spots detected from Dukdong and Dotsum were similar to each other. Fifteen proteins were found to be predicted or undefined proteins, while five proteins were identified as heavy polypeptide 11 of myosin, apolipoprotein A-I, fibroblast growth factor 17b precursor, G protein-coupled receptor kinase 1 b and bonnie and clyde. These data suggest that local fish in the bay area have dysfunction in muscle physiology including contraction, lipid metabolism, proliferation and differentiation and nervous system.

22 CFR 1600.160 - Communications.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Communications. 1600.160 Section 1600.160 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION...

22 CFR 1600.160 - Communications.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Communications. 1600.160 Section 1600.160 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION...

22 CFR 1600.160 - Communications.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Communications. 1600.160 Section 1600.160 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION...

Three New Low-Energy Resonances in the 22Ne(p, γ )23Na Reaction

NASA Astrophysics Data System (ADS)

Cavanna, Francesca; Depalo, Rosanna

The neon-sodium (NeNa) cycle drives the synthesis of the elements between 20Ne and 27Al, through a series of proton capture reactions that start from 20Ne, to end with sodium synthesis. This cycle is active in red giant stars (RGB), asymptotic giant branch stars (AGB), in novae as well as in type Ia supernovae. In order to reproduce the observed elemental abundances, the cross sections of the reactions involved in the nucleosynthesis process should be accurately known. The 22Ne(p, γ )23Na reaction rate was very uncertain because of a large number of unobserved resonances lying in the Gamow window. For proton energies below 400 keV, in the literature there were only upper limits for the resonance strengths. A new direct study of the 22Ne(p, γ )23Na reaction has been performed at the Laboratory for Underground Nuclear Astrophysics (LUNA) in Gran Sasso using a windowless gas target and two high-purity germanium detectors. Several resonances have been observed for the first time in a direct experiment.

22 CFR 126.14 - Special comprehensive export authorizations for NATO, Australia, Japan, and Sweden.

Code of Federal Regulations, 2012 CFR

2012-04-01

... NATO, Australia, Japan, and Sweden. 126.14 Section 126.14 Foreign Relations DEPARTMENT OF STATE... authorizations for NATO, Australia, Japan, and Sweden. (a) Comprehensive authorizations. With respect to NATO members, Australia, Japan, and Sweden, the Directorate of Defense Trade Controls may provide the...

22 CFR 126.14 - Special comprehensive export authorizations for NATO, Australia, Japan, and Sweden.

Code of Federal Regulations, 2013 CFR

2013-04-01

... NATO, Australia, Japan, and Sweden. 126.14 Section 126.14 Foreign Relations DEPARTMENT OF STATE... authorizations for NATO, Australia, Japan, and Sweden. (a) Comprehensive authorizations. With respect to NATO members, Australia, Japan, and Sweden, the Directorate of Defense Trade Controls may provide the...

22 CFR 126.14 - Special comprehensive export authorizations for NATO, Australia, Japan, and Sweden.

Code of Federal Regulations, 2014 CFR

2014-04-01

... NATO, Australia, Japan, and Sweden. 126.14 Section 126.14 Foreign Relations DEPARTMENT OF STATE... authorizations for NATO, Australia, Japan, and Sweden. (a) Comprehensive authorizations. With respect to NATO members, Australia, Japan, and Sweden, the Directorate of Defense Trade Controls may provide the...

22 CFR 1600.140 - Employment.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Employment. 1600.140 Section 1600.140 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.140...

22 CFR 1600.111 - Notice.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Notice. 1600.111 Section 1600.111 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.111...

22 CFR 1600.111 - Notice.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Notice. 1600.111 Section 1600.111 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.111...

22 CFR 1600.102 - Application.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Application. 1600.102 Section 1600.102 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.102...

22 CFR 1600.140 - Employment.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Employment. 1600.140 Section 1600.140 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.140...

22 CFR 1600.101 - Purpose.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Purpose. 1600.101 Section 1600.101 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.101...

22 CFR 1600.140 - Employment.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Employment. 1600.140 Section 1600.140 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.140...

22 CFR 1600.101 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Purpose. 1600.101 Section 1600.101 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.101...

22 CFR 1600.111 - Notice.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Notice. 1600.111 Section 1600.111 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.111...

22 CFR 1600.102 - Application.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Application. 1600.102 Section 1600.102 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.102...

22 CFR 1600.102 - Application.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Application. 1600.102 Section 1600.102 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.102...

22 CFR 1600.102 - Application.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Application. 1600.102 Section 1600.102 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.102...

22 CFR 1600.111 - Notice.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Notice. 1600.111 Section 1600.111 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.111...

22 CFR 1600.101 - Purpose.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Purpose. 1600.101 Section 1600.101 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.101...

22 CFR 1600.101 - Purpose.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Purpose. 1600.101 Section 1600.101 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.101...

22 CFR 1600.140 - Employment.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Employment. 1600.140 Section 1600.140 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.140...

22 CFR 1600.140 - Employment.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Employment. 1600.140 Section 1600.140 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.140...

22 CFR 1600.111 - Notice.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Notice. 1600.111 Section 1600.111 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.111...

22 CFR 1600.101 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Purpose. 1600.101 Section 1600.101 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.101...

22 CFR 1600.102 - Application.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Application. 1600.102 Section 1600.102 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION § 1600.102...

Synthesis of 2-Deoxybrassinosteroids Analogs with 24-nor, 22(S)-23-Dihydroxy-Type Side Chains from Hyodeoxycholic Acid.

PubMed

Carvajal, Rodrigo; González, Cesar; Olea, Andrés F; Fuentealba, Mauricio; Espinoza, Luis

2018-05-29

Natural brassinosteroids are widespread in the plant kingdom and it is known that they play an important role in regulating plant growth. In this study, two new brassinosteroid analogs with shorter side chains but keeping the diol function were synthesized. Thus, the synthesis of 2-deoxybrassinosteroids analogs of the 3α-hydroxy-24-nor, 22,23-dihydroxy-5α-cholestane side chain type is described. The starting material is a derivative from hyodeoxycholic acid ( 4 ), which was obtained with an overall yield of 59% following a previously reported five step route. The side chain of this intermediate was modified by oxidative decarboxylation to get a terminal olefin at the C22-C23 position (compound 20 ) and subsequent dihydroxylation of the olefin. The resulting epimeric mixture of 21a , 21b was separated and the absolute configuration at the C22 carbon for the main product 21a was elucidated by single crystal X-ray diffraction analysis of the benzoylated derivative 22 . Finally, lactonization of 21a through a Baeyer-Villiger oxidation of triacetylated derivative 23 , using CF₃CO₃H/CHCl₃ as oxidant system, leads to lactones 24 and 25 in 35% and 14% yields, respectively. Deacetylation of these compounds leads to 2-deoxybrassinosteroids 18 and 19 in 86% and 81% yields. Full structural characterization of all synthesized compounds was achieved using their 1D, 2D NMR, and HRMS data.

Mid-term periodicities and heliospheric modulation of coronal index and solar flare index during solar cycles 22-23

NASA Astrophysics Data System (ADS)

Singh, Prithvi Raj; Saxena, A. K.; Tiwari, C. M.

2018-04-01

We applied fast Fourier transform techniques and Morlet wavelet transform on the time series data of coronal index, solar flare index, and galactic cosmic ray, for the period 1986-2008, in order to investigate the long- and mid-term periodicities including the Rieger ({˜ }130 to {˜ }190 days), quasi-period ({˜ }200 to {˜ }374 days), and quasi-biennial periodicities ({˜ }1.20 to {˜ }3.27 years) during the combined solar cycles 22-23. We emphasize the fact that a lesser number of periodicities are found in the range of low frequencies, while the higher frequencies show a greater number of periodicities. The rotation rates at the base of convection zone have periods for coronal index of {˜ }1.43 years and for solar flare index of {˜ }1.41 year, and galactic cosmic ray, {˜ }1.35 year, during combined solar cycles 22-23. In relation to these two solar parameters (coronal index and solar flare index), for the solar cycles 22-23, we found that galactic cosmic ray modulation at mid cut-off rigidity (Rc = 2.43GV) is anti-correlated with time-lag of few months.

PUB22 and PUB23 U-BOX E3 ligases directly ubiquitinate RPN6, a 26S proteasome lid subunit, for subsequent degradation in Arabidopsis thaliana.

PubMed

Cho, Seok Keun; Bae, Hansol; Ryu, Moon Young; Wook Yang, Seong; Kim, Woo TaeK

2015-09-04

Drought stress strongly affects plant growth and development, directly connected with crop yields, accordingly. However, related to the function of U-BOX E3 ligases, the underlying molecular mechanisms of desiccation stress response in plants are still largely unknown. Here we report that PUB22 and PUB23, two U-box E3 ligase homologs, tether ubiquitins to 19S proteasome regulatory particle (RP) subunit RPN6, leading to its degradation. RPN6 was identified as an interacting substrate of PUB22 by yeast two-hybrid screening, and in vitro pull-down assay confirmed that RPN6 interacts not only with PUB22, but also with PUB23. Both PUB22 and PUB23 were able to conjugate ubiquitins on RPN6 in vitro. Furthermore, RPN6 showed a shorter protein half-life in PUB22 overexpressing plants than in wild-type, besides RPN6 was significantly stabilized in pub22pub23 double knockout plants. Taken together, these results solidify a notion that PUB22 and PUB23 can alter the activity of 26S proteasome in response to drought stress. Copyright © 2015 Elsevier Inc. All rights reserved.

Seroepidemiological survey of pathogenic Yersinia in breeding squirrel monkeys in Japan.

PubMed

Iwata, Taketoshi; Une, Yumi; Lee, Ken-ichi; Nakamura, Shin-ichi; Taniguchi, Takahide; Hayashidani, Hideki

2010-08-01

To investigate the prevalence of antibodies to pathogenic Yersinia in breeding squirrel monkeys, the serum samples of 252 squirrel monkeys from 9 zoological gardens in Japan were tested by ELISA using plasmid-encoded Yersinia outer membrane protein (Yops) as the antigen. The cutoff value was calculated by using the serum samples of the squirrel monkeys from Suriname, where no prevalence of pathogenic Yersinia have been reported. According to the cutoff value, 164 of 252 (65.1%) squirrel monkeys were considered positive against pathogenic Yersinia. These positive monkeys belonged to 8 of the 9 zoological gardens, and the percentage of the seropositive monkeys ranged from 22.2 to 89.4%. Furthermore, in one zoological garden, the positive rate of the squirrel monkeys which were over 1 year old (95.7%) was significantly higher than those which were under 1 year old (23.3%). These results suggested that pathogenic Yersinia is highly prevalent among breeding monkeys in Japan.

Should Japan Become a Normal Country

DTIC Science & Technology

2005-12-01

9 B. ANCIENT JAPAN: ORIGINS AND ASUKA, NARA, AND HEIAN PERIODS...ANCIENT JAPAN: ORIGINS AND ASUKA, NARA, AND HEIAN PERIODS Japanese culture emerged on Yamato plain around the 2nd and 3rd centuries A.D. and continued...record of ancient matters.22 Immediately following this era was the Heian period during which the imperial court moved to a new, permanent capital

Basic Hearing and Echolocation Mechanisms of Marine Mammals: Measured Auditory Evoked Potential and Behavioral Experiments FY 2007

DTIC Science & Technology

2007-01-01

Breese, M. (2007) Evoked-potential recovery during double click stimulation in a whale: A possibility of biosonar automatic gain control. Journal of...Yokohama Japan (published) Supin A.Ya, Nachtigall, P.E., and Breese, M. Source level to sensation level ratio of transmitted biosonar pulses in an

Patterns of radiotherapy infrastructure in Japan and in other countries with well-developed radiotherapy infrastructures.

PubMed

Nakamura, Katsumasa; Konishi, Kenta; Komatsu, Tetsuya; Sasaki, Tomonari; Shikama, Naoto

2018-05-01

In high-income countries, the number of radiotherapy machine per population reaches a sufficient level. However, the patterns of infrastructure of radiotherapy in high-income countries are not well known. Among 29 high-income countries with gross national income of $25,000 or more per capita, we selected 23 countries whose total number of newly diagnosed cancer patients in 2012 was reported in the Organisation for Economic Co-operation and Development Health Statistics 2017. The numbers of radiotherapy centers and teletherapy machines in each of these 23 countries were collected using the Dictionary of Radiotherapy Centers database. The number of cancer patients per teletherapy machine was 452.35-1398.22 (median 711.66) with a three-fold variation, whereas the number of cancer patients per radiotherapy center varied even more widely, from 826.16 to 5159.86 (median 2259.83) with a six-fold variation. The average number of teletherapy machines per radiotherapy center also ranged widely, from 1.24 to 8.29 (median 3.11) with a seven-fold variation. The number of teletherapy machines in each country was almost proportional to that of cancer patients, and the number of teletherapy machines per radiotherapy center was inversely related to the number of radiotherapy centers per cancer patients. The number of teletherapy machines per radiotherapy center in Japan was 1.24, the most fragmented among the high-income countries. The percentage of large radiotherapy centers having three or more teletherapy machines in Japan was the smallest among 23 high-income countries. Optimization of the radiotherapy infrastructure in Japan should be carefully considered.

22 CFR 1600.110 - Self-evaluation.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Self-evaluation. 1600.110 Section 1600.110 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION...

22 CFR 1600.110 - Self-evaluation.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Self-evaluation. 1600.110 Section 1600.110 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION...

22 CFR 1600.110 - Self-evaluation.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Self-evaluation. 1600.110 Section 1600.110 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION...

22 CFR 1600.110 - Self-evaluation.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Self-evaluation. 1600.110 Section 1600.110 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION...

22 CFR 1600.110 - Self-evaluation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Self-evaluation. 1600.110 Section 1600.110 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP COMMISSION...

22 CFR 126.14 - Special comprehensive export authorizations for NATO, Australia, and Japan.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., Australia, Japan, and Sweden, the Directorate of Defense Trade Controls may provide the comprehensive... a commercial export endeavor including the needed defense exports can be well anticipated and... authorization. With respect to NATO members, Australia, Japan, and Sweden, the Directorate of Defense Trade...

Expedition 23 Docking

NASA Image and Video Library

2010-04-03

The crew of Expedition 23 are seen on a large TV screen in the Russian Mission Control Center in Korolev, Russia, Sunday, April 4, 2010, shortly after the Soyuz TMA-18 spacecraft docked to the International Space Station and delivered Expedition 23 Flight Engineers Alexander Skvortsov, Mikhail Kornienko and Tracy Caldwell Dyson. Clockwise from top right are NASA astronaut TJ Creamer, NASA astronaut Tracy Caldwell Dyson, Russian cosmonaut Alexander Skvortsov, Russian cosmonaut Mikhail Kornienko, JAXA (Japan Aerospace Exploration Agency) astronaut Soichi Noguchi and Expedition 23 commander Russian cosmonaut Oleg Kotov . Photo Credit: (NASA/Carla Cioffi)

Exploring the {sup 22}Ne(p,γ){sup 23}Na reaction at LUNA and at HZDR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cavanna, Francesca; Collaboration: LUNA Collaboration

2014-05-09

The {sup 22}Ne(p,γ){sup 23}Na reaction is involved in the hydrogen burning NeNa cycle. This determines the nucleosynthesis of the Ne and Na isotopes in the Red Giant Branch and Asymptotic Giant Branch phases of stellar evolution. In the energy range relevant for astrophysics (20 keV < E < 600 keV), the {sup 22}Ne(p,γ){sup 23}Na reaction rate is highly uncertain because of the contribution of a large number of resonances never measured directly. A related study is under preparation at the Laboratory for Underground Nuclear Astrophysics (LUNA), in the Gran Sasso National Laboratory, and it will cover the energy range 100more » keV < E < 400 keV. Meanwhile, a measurement at higher energies (i.e. 436 keV) has been carried out at the Tandetron accelerator of the HZDR (Helmholtz Zentrum Dresden Rossendorf) in Germany. Some preliminary results will be presented.« less

Center for Transportation Studies 24th annual transportation research conference, May 22-23, 2013, Saint Paul, Minnesota.

DOT National Transportation Integrated Search

2013-05-01

The University of Minnesotas Center for Transportation : Studies is pleased to present its 24th Annual Transportation : Research Conference, May 22-23, 2013. The conference will : be held at the Saint Paul RiverCentre, 175 West Kellogg : Boulevard...

Isolation of a new anti-inflammatory 20, 21, 22, 23, 24, 25, 26, 27-octanorcucurbitacin-type triterpene from Ibervillea sonorae.

PubMed

Jardón-Delgado, Angel; Magos-Guerrero, Gil Alfonso; Martínez-Vázquez, Mariano

2014-01-01

A new cucurbitane-type triterpene, 20, 21, 22, 23, 24, 25, 26, 27-octanorcucurbita-5-ene-3, 11, 16-trione (1), named kinoin D, was isolated from the roots of the medicinal plant Ibervillea sonorae, (wereque). The structure of 1 was established on the basis of extensive NMR and MS studies. In addition, the known kinoins B (3) and C (5) were isolated, as were 16alpha-20,25-trihydroxy-3alpha-(2-O-alpha-L-rhamnopyranosiyl-D-glucopyranosyloxy)-(10alpha)-cucurbit-5-en-11,22-dione (6), (22S)-16alpha,22-diacetoxy-20,25-dihydroxy-3alpha-[3,4,6-tri-O-acetyl-2-O-(2,3,4-tri-O-acetyl-alpha-L-rhamnopyranosyl)-beta-glucopyranosyl]-(10alpha)-cucurbita-5,23t-dien-11-one (7) and 16alpha-acetoxy-20,25-dihydroxy-3alpha-[3,4,6-tri-O-acetyl-2-O-(2,3,4,-tri-O-acetyl-alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl]-(10alpha)-cucurbita-5-ene-11,22-dione (8). Compound 1 exhibited anti-inflammatory activity in TPA-induced edema in mice.

Acute toxic tests of rainwater samples using Daphnia magna.

PubMed

Sakai, Manabu

2006-06-01

Rainwater samples were collected at Isogo Ward of Yokohama City, Japan, from 23 June to 31 July 2003. The toxic potency of pollutants present in 13 rainwater samples was tested using Daphnia magna. Most test animals died within 48 h in five test solutions that were prepared from rainwater samples. On the other hand, when nonpolar compounds such as pesticides were removed from rainwater samples before the toxic tests, mortalities in all test solutions were less than 10%. Eight kinds of pesticides were detected in rainwater samples. The highest concentration was of dichlorvos, at 0.74 microg/L. Results indicated that insecticides in rainwater sometimes lethally affected D. magna and that toxic potency of insecticides that are present in rainwater constitutes an important problem for environmental protection.

22 CFR 401.23 - Hearings.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Relations INTERNATIONAL JOINT COMMISSION, UNITED STATES AND CANADA RULES OF PROCEDURE Applications § 401.23... of the hearing or hearings to the applicant, the Governments and all persons who have presented... applicant, the Governments and persons interested are entitled to present oral and documentary evidence and...

Instability study for LOFT for L2-1, L2-2, and L2-3 pretest steady-state operating conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eide, S.A.

The results are presented of a thermal-hydrodynamic flow instability study of the LOFT reactor for the L2-1, L2-2, and L2-3 pretest steady-state operating conditions. Comparison is made between the LOFT reactor and a typical PWR, and the effects on stability of differences in operating parameters and geometry are discussed. Results indicate that the LOFT reactor will be thermal-hydrodynamically stable for nominal and worst case operating conditions. The study supports the LOFT Experimental Safety Analyses for the L2-1, L2-2, and L2-3 tests.

Proceedings of Symposium on Physics of Target Implosion and Pulsed Power Techniques Held in Yokohama, Japan on 30 September-1 October 1987

DTIC Science & Technology

1988-02-01

Japan. -- ,, mnm mmmm m m mil II m mlmmmm PREFACE A It is reported that by using the Nd glass laser, experiments of beam-target interaction are carried...Beam 8. 14.00-14.30 T. Ishimoto and T. Kato (Waseda Univ.) Electron Current Effect on Stability of Plasma Channel 9. 14.30-15.00 S. Kawata, M ...Matsumoto and Y. Masubuchi (Tech. Univ. Nagaoka) Numerical Simulation in LIB ICF 10. 15.00-15.30 J. M . Perlado (Univ. Politec. Madrid) Simulation Code for ICF

IL-22 Production Is Regulated by IL-23 During Listeria monocytogenes Infection but Is Not Required for Bacterial Clearance or Tissue Protection

PubMed Central

Graham, Amy C.; Carr, Karen D.; Sieve, Amy N.; Indramohan, Mohanalaxmi; Break, Timothy J.; Berg, Rance E.

2011-01-01

Listeria monocytogenes (LM) is a gram-positive bacterium that is a common contaminant of processed meats and dairy products. In humans, ingestion of LM can result in intracellular infection of the spleen and liver, which can ultimately lead to septicemia, meningitis, and spontaneous abortion. Interleukin (IL)-23 is a cytokine that regulates innate and adaptive immune responses by inducing the production of IL-17A, IL-17F, and IL-22. We have recently demonstrated that the IL-23/IL-17 axis is required for optimal recruitment of neutrophils to the liver, but not the spleen, during LM infection. Furthermore, these cytokines are required for the clearance of LM during systemic infection. In other infectious models, IL-22 induces the secretion of anti-microbial peptides and protects tissues from damage by preventing apoptosis. However, the role of IL-22 has not been thoroughly investigated during LM infection. In the present study, we show that LM induces the production of IL-22 in vivo. Interestingly, IL-23 is required for the production of IL-22 during primary, but not secondary, LM infection. Our findings suggest that IL-22 is not required for clearance of LM during primary or secondary infection, using both systemic and mucosal models of infection. IL-22 is also not required for the protection of LM infected spleens and livers from organ damage. Collectively, these data indicate that IL-22 produced during LM infection must play a role other than clearance of LM or protection of tissues from pathogen- or immune-mediated damage. PMID:21347242

Recent increases in the atmospheric growth rate and emissions of HFC-23 (CHF3) and the link to HCFC-22 (CHClF2) production

NASA Astrophysics Data System (ADS)

Simmonds, Peter G.; Rigby, Matthew; McCulloch, Archie; Vollmer, Martin K.; Henne, Stephan; Mühle, Jens; O'Doherty, Simon; Manning, Alistair J.; Krummel, Paul B.; Fraser, Paul J.; Young, Dickon; Weiss, Ray F.; Salameh, Peter K.; Harth, Christina M.; Reimann, Stefan; Trudinger, Cathy M.; Steele, L. Paul; Wang, Ray H. J.; Ivy, Diane J.; Prinn, Ronald G.; Mitrevski, Blagoj; Etheridge, David M.

2018-03-01

High frequency measurements of trifluoromethane (HFC-23, CHF3), a potent hydrofluorocarbon greenhouse gas, largely emitted to the atmosphere as a by-product of the production of the hydrochlorofluorocarbon HCFC-22 (CHClF2), at five core stations of the Advanced Global Atmospheric Gases Experiment (AGAGE) network, combined with measurements on firn air, old Northern Hemisphere air samples and Cape Grim Air Archive (CGAA) air samples, are used to explore the current and historic changes in the atmospheric abundance of HFC-23. These measurements are used in combination with the AGAGE 2-D atmospheric 12-box model and a Bayesian inversion methodology to determine model atmospheric mole fractions and the history of global HFC-23 emissions. The global modelled annual mole fraction of HFC-23 in the background atmosphere was 28.9 ± 0.6 pmol mol-1 at the end of 2016, representing a 28 % increase from 22.6 ± 0.4 pmol mol-1 in 2009. Over the same time frame, the modelled mole fraction of HCFC-22 increased by 19 % from 199 ± 2 to 237 ± 2 pmol mol-1. However, unlike HFC-23, the annual average HCFC-22 growth rate slowed from 2009 to 2016 at an annual average rate of -0.5 pmol mol-1 yr-2. This slowing atmospheric growth is consistent with HCFC-22 moving from dispersive (high fractional emissions) to feedstock (low fractional emissions) uses, with HFC-23 emissions remaining as a consequence of incomplete mitigation from all HCFC-22 production.Our results demonstrate that, following a minimum in HFC-23 global emissions in 2009 of 9.6 ± 0.6, emissions increased to a maximum in 2014 of 14.5 ± 0.6 Gg yr-1 and then declined to 12.7 ± 0.6 Gg yr-1 (157 Mt CO2 eq. yr-1) in 2016. The 2009 emissions minimum is consistent with estimates based on national reports and is likely a response to the implementation of the Clean Development Mechanism (CDM) to mitigate HFC-23 emissions by incineration in developing (non-Annex 1) countries under the Kyoto Protocol. Our derived cumulative

Web-based Recruiting for a Survey on Knowledge and Awareness of Cervical Cancer Prevention Among Young Women Living in Kanagawa Prefecture, Japan

PubMed Central

Miyagi, Etsuko; Motoki, Yoko; Asai-Sato, Mikiko; Taguri, Masataka; Morita, Satoshi; Hirahara, Fumiki; Wark, John D.; Garland, Suzanne M.

2014-01-01

Objectives Cervical cancer (CC) incidence and mortality among young women have been increasing in Japan. To develop effective measures to combat this, we assessed the feasibility of using a social networking site (SNS) to recruit a representative sample of young women to conduct a knowledge and attitude study about CC prevention via an internet-based questionnaire. Methods From July 2012 to March 2013, advertising banners targeting women aged 16 to 35 years in Kanagawa Prefecture were placed on Facebook in a similar manner as an Australian (AUS) study conducted in 16- to 25-year-olds in 2010 and on a homepage to advertise our CC advocacy activities. Eligible participants were emailed instructions for accessing our secure Web site where they completed an online survey including demographics, awareness, and knowledge of human papillomavirus (HPV) and CC. Data for the study population were compared with the general Japanese population and the AUS study. Results Among 394 women who expressed interest, 243 (62%) completed the survey, with 52% completing it via Facebook. Women aged 26 to 35 years, living in Yokohama City, with an education beyond high school, were overrepresented. Participants had high awareness and knowledge of HPV and CC, comparable with the AUS study participants. However, the self-reported HPV vaccination rate (22% among participants aged 16–25 years) and the recognition rate of the link between smoking and CC (31%) were significantly lower than in the AUS study (58% and 43%, respectively) (P < 0.05). Significant predictors of high knowledge scores about HPV included awareness of HPV vaccine (P < 0.001) and self-reported HPV vaccination (P < 0.05). Conclusions The SNS and homepage are efficient methods to recruit young women into health surveys, which can effectively be performed online. A nationwide survey using SNSs would be an appropriate next step to better understand the current lack of uptake of the national HPV vaccine program by young women

Web-based recruiting for a survey on knowledge and awareness of cervical cancer prevention among young women living in Kanagawa prefecture, Japan.

PubMed

Miyagi, Etsuko; Motoki, Yoko; Asai-Sato, Mikiko; Taguri, Masataka; Morita, Satoshi; Hirahara, Fumiki; Wark, John D; Garland, Suzanne M

2014-09-01

Cervical cancer (CC) incidence and mortality among young women have been increasing in Japan. To develop effective measures to combat this, we assessed the feasibility of using a social networking site (SNS) to recruit a representative sample of young women to conduct a knowledge and attitude study about CC prevention via an internet-based questionnaire. From July 2012 to March 2013, advertising banners targeting women aged 16 to 35 years in Kanagawa Prefecture were placed on Facebook in a similar manner as an Australian (AUS) study conducted in 16- to 25-year-olds in 2010 and on a homepage to advertise our CC advocacy activities. Eligible participants were emailed instructions for accessing our secure Web site where they completed an online survey including demographics, awareness, and knowledge of human papillomavirus (HPV) and CC. Data for the study population were compared with the general Japanese population and the AUS study. Among 394 women who expressed interest, 243 (62%) completed the survey, with 52% completing it via Facebook. Women aged 26 to 35 years, living in Yokohama City, with an education beyond high school, were overrepresented. Participants had high awareness and knowledge of HPV and CC, comparable with the AUS study participants. However, the self-reported HPV vaccination rate (22% among participants aged 16-25 years) and the recognition rate of the link between smoking and CC (31%) were significantly lower than in the AUS study (58% and 43%, respectively) (P < 0.05). Significant predictors of high knowledge scores about HPV included awareness of HPV vaccine (P < 0.001) and self-reported HPV vaccination (P < 0.05). The SNS and homepage are efficient methods to recruit young women into health surveys, which can effectively be performed online. A nationwide survey using SNSs would be an appropriate next step to better understand the current lack of uptake of the national HPV vaccine program by young women in Japan.

A Boy with an LCR3/4-Flanked 10q22.3q23.2 Microdeletion and Uncommon Phenotypic Features

PubMed Central

Petrova, E.; Neuner, C.; Haaf, T.; Schmid, M.; Wirbelauer, J.; Jurkutat, A.; Wermke, K.; Nanda, I.; Kunstmann, E.

2014-01-01

The recurrent 10q22.3q23.2 deletion with breakpoints within low copy repeats 3 and 4 is a rare genomic disorder, reported in only 13 patients to date. The phenotype is rather uncharacteristic, which makes a clinical diagnosis difficult. A phenotypic feature described in almost all patients is a delay in speech development, albeit systematic studies are still pending. In this study, we report on a boy with an LCR3/4-flanked 10q22.3q23.2 deletion exhibiting an age-appropriate language development evaluated by a standardized test at an age of 2 years and 3 months. The boy was born with a cleft palate – a feature not present in any of the patients described before. Previously reported cases are reviewed, and the role of the BMPR1A gene is discussed. The phenotype of patients with an LCR3/4-flanked 10q22.3q23.2 deletion can be rather variable, so counseling the families regarding the prognosis of an affected child should be done with caution. Long-term studies of affected children are needed to delineate the natural history of this rare disorder. PMID:24550761

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Renal cell carcinoma and a constitutional t(11;22)(q23;q11.2): case report and review of the potential link between the constitutional t(11;22) and cancer.

PubMed

Doyen, Jérôme; Carpentier, Xavier; Haudebourg, Juliette; Hoch, Benjamin; Karmous-Benailly, Houda; Ambrosetti, Damien; Fabas, Thibault; Amiel, Jean; Lambert, Jean-Claude; Pedeutour, Florence

2012-11-01

We observed a t(11;22)(q23-24;q11.2-12) and monosomy 3 in renal tumor cells from a 72-year-old man. The hypothesis of a primitive peripheral neuroectodermal tumor (PPNET) located in the kidney was promptly excluded: Histologically, the tumor was a clear cell renal cell carcinoma (RCC) and we did not observe an EWSR1 gene rearrangement. The constitutional origin of this alteration was established. We report on the second case of RCC in a patient with a constitutional t(11;22). The t(11;22)(q23;q11.2) is the main recurrent germline translocation in humans. Unbalanced translocation can be transmitted to the progeny and can cause Emanuel syndrome. Our observation alerts cancer cytogeneticists to the fortuitous discovery of the constitutional t(11;22) in tumor cells. This translocation appears grossly similar to the t(11;22)(q24;q12) of PPNET and should be evoked if present in all cells of a tumor other than PPNET. This is important when providing appropriate genetic counseling. Moreover, the potential oncogenic role of the t(11;22) and its predisposing risk of cancer are under debate. The family history of the patient revealed a disabled brother who died at an early age from colon cancer and a sister with breast cancer. This observation reopens the issue of a link between the constitutional t(11;22) and cancer, and the utility of cancer prevention workups for t(11;22) carriers. Copyright © 2012 Elsevier Inc. All rights reserved.

Karojisatsu in Japan: characteristics of 22 cases of work-related suicide.

PubMed

Amagasa, Takashi; Nakayama, Takeo; Takahashi, Yoshitomo

2005-03-01

With the rapidly increasing number of work-related suicides in Japan (Karojisatsu, in Japanese), both applications for worker's compensation insurance and civil suits are proliferating. The phenomenon of work-related suicide is examined along with the process and related factors. With informed consent from bereaved families, two certified psychiatrists independently reviewed and summarized 22 insurance and legal reports filed by psychiatrists on employee suicides that were related to heavy workloads. A clinical epidemiologist participated in discussions with psychiatrists to reach a consensus concerning the cause of the suicides. Only one case involved a female. Seventeen had experienced personnel changes, such as a promotion or transfer. Low social support was recognized in 18, high psychological demand in 18, low decision latitude in 17, and long working hours in 19 cases (more than 11 hours per day for 3 months or more, and without a day off in 9). The subjects had depressive episodes by the ICD-10 criteria and showed suicidal signs. Ten of them saw a general practitioner because of unspecified somatic complaints, but no effective measures were taken. None of them had a history of psychiatric consultation or had received mental health education dealing with job stress management. Although causality cannot be made from this case series report, we hypothesize that long working hours, heavy workloads, and low social support may cause depression, which can lead to suicide. Appropriate countermeasures are urgently needed and the present findings suggest some of them are possible.

Uses of Integrated Media Instruction in a Self-Contained Class for Children with Mild Disabilities.

ERIC Educational Resources Information Center

Narita, Shigeru

This conference paper describes the use of integrated media-oriented instruction in a self-contained class at Yokohama Municipal Elementary School in Japan. Three students with mild disabilities, in grades 5 and 6, participated in the project. Integrated media (IM) is defined as the linkage of text, sound, video, graphics, and the computer in such…

Linkage analysis of chromosome 22q12-13 in a United Kingdom/Icelandic sample of 23 multiplex schizophrenia families

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalsi, G.; Read, T.; Butler, R.

A possible linkage to a genetic subtype of schizophrenia and related disorders has been reported on the long arm of chromosome 22 at q12-13. However formal statistical tests in a combined sample could not reject homogeneity and prove that there was linked subgroup of families. We have studied 23 schizophrenia pedigrees to test whether some multiplex schizophrenia families may be linked to the microsatellite markers D22S274 and D22S283 which span the 22q12-13 region. Two point followed by multipoint lod and non-parametric linkage analyses under the assumption of heterogeneity provided no evidence for linkage over the relevant region. 16 refs., 4more » tabs.« less

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... 22 Foreign Relations 2 2010-04-01 2010-04-01 true General prohibitions against discrimination. 1600.130 Section 1600.130 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP...

22 CFR 1600.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Program accessibility: Existing facilities. 1600.150 Section 1600.150 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP...

A summary of the SOTANCP3 workshop

NASA Astrophysics Data System (ADS)

Baye, Daniel

2014-12-01

This text summarizes the talks presented at the 3rd International Workshop on State of the Art in Nuclear Cluster Physics (SOTANCP3) held in Yokohama (Japan) from 26 to 30 May 2014. Some personal opinions are also expressed on two much debated topics: the 12C spectrum in the continuum and conflicting interpretations of cluster wave functions.

Tokyo, Yokohama and Tokoy Bay as seen from STS-58

NASA Technical Reports Server (NTRS)

1993-01-01

Japan's modern megalopolis is seen in this nadir view in great detail. More than 80 vessels can be seen at the anchorage's in Tokyo Bay. The gardens of the Emperor's Palace are seen in this circular area in the upper left quadrant.

Atmospheric deposition of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in the Kanto Region, Japan.

PubMed

Ogura, I; Masunaga, S; Nakanishi, J

2001-09-01

The atmospheric bulk (dry and wet) deposition of dioxins was investigated at four locations (Tokyo, Yokohama, Tsukuba, and Tanzawa) in the Kanto region (in Japan) over one year using a stainless-steel pot. Annual average polychlorinated dibenzo-p-dioxins/polychlorinated dibenzofurans (PCDD/PCDF) deposition fluxes were estimated to be from 450 to 1300 ng/m2/yr, and the annual average TEQ fluxes from 5.7 to 17 ng-TEQ/m2/yr at the four locations. The PCDD/PCDF deposition flux was higher in winter than in summer. The deposition flux could be related to ambient temperature, particularly for less chlorinated PCDDs/PCDFs, while the deposition flux is not necessarily related to the amount of precipitation. The PCDD/PCDF deposition flux increased as the particle deposition flux increased, for the winter samples. Based on the ratio of the PCDD/PCDF deposition fluxes to the particle deposition fluxes, the contribution of the reentrainment of soil particles to the TEQ of PCDD/PCDF deposition was considered to be negligible in this region. Based on the air concentrations monitored near our deposition sampling points by the municipalities, the ratio of the annual deposition flux to the annual average air concentration was roughly estimated to be 0.082 cm/s. The range of deposition flux in the Kanto region was estimated to be from 1.5 to 31 (median: 9.8) ng-TEQ/m2/yr based on the range of air concentration data measured by the municipalities. The total annual deposition flux in the entire Kanto region was estimated to range from 50 to 900 g-TEQ/yr (median 320 g-TEQ/yr). This estimated flux was of the same order as the sum of estimated emissions from municipal solid waste incinerators and industrial waste incinerators in the Kanto region. The contributions of dioxin-like PCBs in Yokohama, Tsukuba, and Tanzawa depositions were less than 10% of the total TEQ; however, in Tokyo it was almost equal to or more than 50%.

Effect of Temperature on Growth and Sporulation of US-22, US-23, and US-24 Clonal Lineages of Phytophthora infestans and Implications for Late Blight Epidemiology.

PubMed

Seidl Johnson, Anna C; Frost, Kenneth E; Rouse, Douglas I; Gevens, Amanda J

2015-04-01

Epidemics of late blight, caused by Phytophthora infestans (Mont.) de Bary, have been studied by plant pathologists and regarded with great concern by potato and tomato growers since the Irish potato famine in the 1840s. P. infestans populations have continued to evolve, with unique clonal lineages arising which differ in pathogen fitness and pathogenicity, potentially impacting epidemiology. In 2012 and 2013, the US-23 clonal lineage predominated late blight epidemics in most U.S. potato and tomato production regions, including Wisconsin. This lineage was unknown prior to 2009. For isolates of three recently identified clonal lineages of P. infestans (US-22, US-23, and US-24), sporulation rates were experimentally determined on potato and tomato foliage and the effect of temperature on lesion growth rate on tomato was investigated. The US-22 and US-23 isolates had greater lesion growth rates on tomato than US-24 isolates. Sporulation rates for all isolates were greater on potato than tomato, and the US-23 isolates had greater sporulation rates on both tomato and potato than the US-22 and US-24 isolates. Experimentally determined correlates of fitness were input to the LATEBLIGHT model and epidemics were simulated using archived Wisconsin weather data from four growing seasons (2009 to 2012) to investigate the effect of isolates of these new lineages on late blight epidemiology. The fast lesion growth rates of US-22 and US-23 isolates resulted in severe epidemics in all years tested, particularly in 2011. The greater sporulation rates of P. infestans on potato resulted in simulated epidemics that progressed faster than epidemics simulated for tomato; the high sporulation rates of US-23 isolates resulted in simulated epidemics more severe than simulated epidemics of isolates of the US-22 and US-24 isolates and EC-1 clonal lineages on potato and tomato. Additionally, US-23 isolates consistently caused severe simulated epidemics when lesion growth rate and sporulation

HEMISPHERIC ASYMMETRIES IN THE POLAR SOLAR WIND OBSERVED BY ULYSSES NEAR THE MINIMA OF SOLAR CYCLES 22 AND 23

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ebert, R. W.; Dayeh, M. A.; Desai, M. I.

2013-05-10

We examined solar wind plasma and interplanetary magnetic field (IMF) observations from Ulysses' first and third orbits to study hemispheric differences in the properties of the solar wind and IMF originating from the Sun's large polar coronal holes (PCHs) during the declining and minimum phase of solar cycles 22 and 23. We identified hemispheric asymmetries in several parameters, most notably {approx}15%-30% south-to-north differences in averages for the solar wind density, mass flux, dynamic pressure, and energy flux and the radial and total IMF magnitudes. These differences were driven by relatively larger, more variable solar wind density and radial IMF betweenmore » {approx}36 Degree-Sign S-60 Degree-Sign S during the declining phase of solar cycles 22 and 23. These observations indicate either a hemispheric asymmetry in the PCH output during the declining and minimum phase of solar cycles 22 and 23 with the southern hemisphere being more active than its northern counterpart, or a solar cycle effect where the PCH output in both hemispheres is enhanced during periods of higher solar activity. We also report a strong linear correlation between these solar wind and IMF parameters, including the periods of enhanced PCH output, that highlight the connection between the solar wind mass and energy output and the Sun's magnetic field. That these enhancements were not matched by similar sized variations in solar wind speed points to the mass and energy responsible for these increases being added to the solar wind while its flow was subsonic.« less

Characteristics of Wet Deposition in Japan

NASA Astrophysics Data System (ADS)

Iwasaki, A.; Arakaki, T.

2017-12-01

Acid deposition survey in Japan has started since 1991 by Japan Environmental Laboratories Association (JELA). The JELA has about 60 monitoring sites for wet deposition including remote, rural and urban area. The measured constituents of wet deposition are; precipitation, pH, electric conductivity, major Anions, and major Cations. From those data, we analyze spatial and temporal variations of wet deposition components in Japan. Among the 60 monitoring sites, 39 sampling sites were selected in this study, which have kept sampling continuously between 2003JFY and 2014JFY. All samples were collected by wet-only samplers. To analyze area characteristics, all the areas were divided into 6 regions; Northern part of Japan (NJ), Facing the Japan Sea (JS), Eastern part of Japan (EJ), Central part of Japan (CJ), Western part of Japan (WJ) and Southern West Islands (SW). NO3- and non-sea-salt-SO42- (nss-SO42-) are major components of rain acidification. Especially, between December and February (winter) the air mass from west affected the temporal variations of those acid components and the concentrations were higher in JS and WJ regions than those in other regions. Japanese ministry of the Environment reported that mixing ratio of NO2 in Japan has been less than 0.04ppm since 1976, and that of SO2 has been less than 0.02ppm since 1978. Their concentrations in Japan have remained flat or slowly decreased recently. However the temporal variations of NO3-/nss-SO42- ratio in winter in JS region were significantly increased on average at 2.2% y-1 from 2003JFY to 2014JFY. The results suggest that long-range transboundary air pollutants increased NO3- concentrations and NO3-/nss-SO42- ratio.

Expedition 22 Launch Day

NASA Image and Video Library

2009-12-20

Expedition 22 Soyuz Commander Oleg Kotov of Russia listens to an audio check on his headset after donning his Russian Sokol suit at the Baikonur Cosmodrome in Baikonur, Kazakhstan, Sunday, Dec. 20, 2009. Kotov and fellow Expedition 22 crew members, NASA Flight Engineer Timothy J. Creamer of the U.S., and Flight Engineer Soichi Noguchi of Japan launched in their Soyuz TMA-17 rocket from the Baikonur Cosmodrome in Kazakhstan on Monday, Dec. 21, 2009. (Photo Credit: NASA/Bill Ingalls)

22 CFR 1600.151 - Program accessibility: New construction and alterations.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Program accessibility: New construction and alterations. 1600.151 Section 1600.151 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED...

ONRASIA Scientific Information Bulletin. Volume 8, Number 3, July- September 1993

DTIC Science & Technology

1993-09-01

the Ninth Symposium on Preconditioned Conjugate Dr. Steven F. Ashby Gradient Methods , which he organized. Computing Sciences Department Computing...ditioned Conjugate Gradient Methods , held at Keio chines and is currently a topic of considerable University (Yokohama). During this meeting, I interest...in the United States. In Japan, on the other discussed iterative methods for linear systems with hand, this technique does not appear to be too well

Characterization of Navy Solid Waste and Collection and Disposal Practices.

DTIC Science & Technology

1980-01-01

26 A-7 Calculation of Design Capacity for Sample Cases.......A-30 A-8 Incineration Plant Capacities Considered for Economic Analysis ...CONSIDERED FOR ECONOMIC ANALYSIS Approximate Quantity of Plant Design Quantity of No. of Shifts Refuse Generateda Capacityb Refuse Burned Operated (tons/day...including a site visit to the 50-ton/day plant in Yokohama, Japan. (2) A preliminary technoeconomic evaluation of a fluidized bed combustor (preceded

22 CFR 1600.160 - Communications.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Communications. 1600.160 Section 1600.160 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS... § 1600.160 Communications. (a) The agency shall take appropriate steps to ensure effective communication...

22 CFR 1600.160 - Communications.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Communications. 1600.160 Section 1600.160 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS... § 1600.160 Communications. (a) The agency shall take appropriate steps to ensure effective communication...

Frequency Management Engineering Principles--Spectrum Measurements (Reference Order 6050.23).

DTIC Science & Technology

1982-08-01

Interference 22 (a) Dielectric Heater Example 22 (b) High Power FM Interference Examle 22 (c) Radar Interference Example 22 (d) ARSR Interference Example...Localizer 23 (i) Dielectric Heaters 23 (j) High Power TV/FM 23 (k) Power Line Noise 23 (1) Incidental Radiating Devices 23 (m) Super-regenerative...employing broad band power amplifiers or and random spectrum analyzer instabilities traveling wave tubes. The "cleanest" spectrums create drift problems

Highlights of B/D-HPP and HPP Resource Pillar Workshops at 12th Annual HUPO World Congress of Proteomics: September 14-18, 2013, Yokohama, Japan.

PubMed

Aebersold, Ruedi; Bader, Gary D; Edwards, Aled M; van Eyk, Jennifer; Kussman, Martin; Qin, Jun; Omenn, Gilbert S

2014-05-01

At the 12th Annual HUPO World Congress of Proteomics in Japan, the Human Proteome Project (HPP) presented 16 scientific workshop sessions. Here we summarize highlights of ten workshops from the Biology and Disease-driven HPP (B/D-HPP) teams and three from the HPP Resource Pillars. Highlights of the three Chromosome-centric HPP sessions appeared in the many articles of the 2014 C-HPP special issue of the Journal of Proteome Research . © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Food-dependent exercise-induced anaphylaxis in Japanese elementary school children.

PubMed

Manabe, Tetsuharu; Oku, Norihiro; Aihara, Yukoh

2018-04-01

In 2012, we clarified that the prevalence of food-dependent exercise-induced anaphylaxis (FDEIA) was 0.018% in junior-high students in Yokohama, Japan. Furthermore, although different from FDEIA, one student who had completed oral immunotherapy developed anaphylaxis during exercise after eating causative food. There have been few large-scale epidemiological studies of FDEIA, however, in elementary school children, therefore we conducted an epidemiological study in elementary school children in Yokohama to clarify the frequency and characteristic of FDEIA. We sent a questionnaire regarding the occurrence of FDEIA to all 348 public elementary school nurses in Yokohama. We also compared the results with those for junior-high school that we previously reported. We excluded those children with a past history of immediate food allergy who had achieved desensitization status after oral immunotherapy, from FDEIA, and instead defined them as having desensitization status and exercise-induced anaphylaxis (DEIA). Of 348 school nurses, 317 responded (91.1%). Overall, eight of 170 146 children were diagnosed with FDEIA, which was significantly lower than the prevalence in junior-high school students (0.0047% vs 0.018%, P = 0.0009). The causative foods were wheat (n = 4), and soy, fruit, crustaceans, and squid (n = 1 each). Four children had DEIA and the causative foods were wheat and milk (n = 2 each). Multiple episodes occurred in five children with FDEIA and in three children with DEIA. FDEIA was far less common in elementary school than in junior-high school, and wheat was the major causative food. The new appearance of DEIA was notable. Decreasing episode recurrence remains an issue that needs to be resolved. © 2018 Japan Pediatric Society.

An International Comparison of Death Classification at 22 to 25 Weeks' Gestational Age.

PubMed

Smith, Lucy K; Morisaki, Naho; Morken, Nils-Halvdan; Gissler, Mika; Deb-Rinker, Paromita; Rouleau, Jocelyn; Hakansson, Stellan; Kramer, Michael R; Kramer, Michael S

2018-06-13

To explore international differences in the classification of births at extremely low gestation and the subsequent impact on the calculation of survival rates. We used national data on births at 22 to 25 weeks' gestation from the United States (2014; n = 11 144), Canada (2009-2014; n = 5668), the United Kingdom (2014-2015; n = 2992), Norway (2010-2014; n = 409), Finland (2010-2015; n = 348), Sweden (2011-2014; n = 489), and Japan (2014-2015; n = 2288) to compare neonatal survival rates using different denominators: all births, births alive at the onset of labor, live births, live births surviving to 1 hour, and live births surviving to 24 hours. For births at 22 weeks' gestation, neonatal survival rates for which we used live births as the denominator varied from 3.7% to 56.7% among the 7 countries. This variation decreased when the denominator was changed to include stillbirths (ie, all births [1.8%-22.3%] and fetuses alive at the onset of labor [3.7%-38.2%]) or exclude early deaths and limited to births surviving at least 12 hours (50.0%-77.8%). Similar trends were seen for infants born at 23 weeks' gestation. Variation diminished considerably at 24 and 25 weeks' gestation. International variation in neonatal survival rates at 22 to 23 weeks' gestation diminished considerably when including stillbirths in the denominator, revealing the variation arises in part from differences in the proportion of births reported as live births, which itself is closely connected to the provision of active care. Copyright © 2018 by the American Academy of Pediatrics.

Genetic divergence in nuclear genomes between populations of Fagus crenata along the Japan Sea and Pacific sides of Japan.

PubMed

Hiraoka, Koichi; Tomaru, Nobuhiro

2009-05-01

Genetic diversity and structure in Fagus crenata were studied by analyzing 14 nuclear microsatellite loci in 23 populations distributed throughout the species' range. Although population differentiation was very low (F (ST) = 0.027; R (ST) = 0.041), both neighbor-joining tree and Bayesian clustering analyses provided clear evidence of genetic divergence between populations along the Japan Sea (Japan Sea lineage) and Pacific (Pacific lineage) sides of Japan, indicating that physical barriers to migration and gene flow, notably the mountain ranges separating the populations along the Japan Sea and Pacific sides, have promoted genetic divergence between these populations. The two lineages of the nuclear genome are generally consistent with those of the chloroplast genome detected in a previous study, with several discrepancies between the two genomes. Within-population genetic diversity was generally very high (average H (E) = 0.839), but decreased in a clinal fashion from southwest to northeast, largely among populations of the Japan Sea lineage. This geographical gradient may have resulted from the late-glacial and postglacial recolonization to the northeast, which led to a loss of within-population genetic diversity due to cumulative founder effects.

Attributable causes of cancer in Japan in 2005--systematic assessment to estimate current burden of cancer attributable to known preventable risk factors in Japan.

PubMed

Inoue, M; Sawada, N; Matsuda, T; Iwasaki, M; Sasazuki, S; Shimazu, T; Shibuya, K; Tsugane, S

2012-05-01

To contribute to evidence-based policy decision making for national cancer control, we conducted a systematic assessment to estimate the current burden of cancer attributable to known preventable risk factors in Japan in 2005. We first estimated the population attributable fractions (PAFs) of each cancer attributable to known risk factors from relative risks derived primarily from Japanese pooled analyses and large-scale cohort studies and the prevalence of exposure in the period around 1990. Using nationwide vital statistics records and incidence estimates, we then estimated the attributable cancer incidence and mortality in 2005. In 2005, ≈ 55% of cancer among men was attributable to preventable risk factors in Japan. The corresponding figure was lower among women, but preventable risk factors still accounted for nearly 30% of cancer. In men, tobacco smoking had the highest PAF (30% for incidence and 35% for mortality, respectively) followed by infectious agents (23% and 23%). In women, in contrast, infectious agents had the highest PAF (18% and 19% for incidence and mortality, respectively) followed by tobacco smoking (6% and 8%). In Japan, tobacco smoking and infections are major causes of cancer. Further control of these factors will contribute to substantial reductions in cancer incidence and mortality in Japan.

Multispacecraft Observations and Modeling of the 22/23 June 2015 Geomagnetic Storm

NASA Technical Reports Server (NTRS)

Reiff, P. H.; Daou, A. G.; Sazykin, S. Y.; Nakamura, R.; Hairston, M. R.; Coffey, V.; Chandler, M. O.; Anderson, B. J.; Russell, C. T.; Welling, D.;

Proceedings of the International Symposium on Multiple-Valued Logic (13th) Held at Kyoto, Japan on May 23-25, 1983.

DTIC Science & Technology

1983-05-01

would like to thank the members of the Organizing Committee of ISMVL-Japan, listed on page vii of this Proceedings, for their generous support. Hisashi ...8217 °. °- . ’. . 6% Organizing Commnittee I *Chairman: Hisashi Mine Department of Applied Mathematics and Physics Kcyoto University, Kyoto...Masayuki Kimura (Tohoku University, Japan) Tadahiro Kitahashi (Toyohashi University of Technology, Japan) Yoshiaki Koga (National Defense Academy, Japan

Calculation and Comparative Analysis of the IR Spectra of Homobrassinolide and (22S,23S)-Homobrassinolide

NASA Astrophysics Data System (ADS)

Andrianov, V. M.; Korolevich, M. V.

2015-09-01

Normal vibrational frequencies and absolute IR band intensities of the biologically active steroid phytohormones homobrassinolide and (22S,23S)-homobrassinolide were calculated in the framework of an original approach that combined classical analysis of normal modes using molecular mechanics with quantum-chemical estimation of the absolute intensities. IR absorption bands were interpreted based on a comparison of the experimental and theoretical absorption spectra. The impact of structural differences in the side chains of these molecules on the formation of their IR spectra in the region 1500-950 cm -1 was estimated.

Welcome Address

NASA Astrophysics Data System (ADS)

Kiku, H.

2014-12-01

Ladies and Gentlemen, It is an honor for me to present my welcome address in the 3rd International Workshop on "State of the Art in Nuclear Cluster Physics"(SOTANCP3), as the president of Kanto Gakuin University. Particularly to those from abroad more than 17 countries, I am very grateful for your participation after long long trips from your home to Yokohama. On the behalf of the Kanto Gakuin University, we certainly welcome your visit to our university and stay in Yokohama. First I would like to introduce Kanto Gakuin University briefly. Kanto Gakuin University, which is called KGU, traces its roots back to the Yokohama Baptist Seminary founded in 1884 in Yamate, Yokohama. The seminary's founder was Albert Arnold Bennett, alumnus of Brown University, who came to Japan from the United States to establish a theological seminary for cultivating and training Japanese missionaries. Now KGU is a major member of the Kanto Gakuin School Corporation, which is composed of two kindergartens, two primary schools, two junior high schools, two senior high schools as well as KGU. In this university, we have eight faculties with graduate school including Humanities, Economics, Law, Sciences and Engineering, Architecture and Environmental Design, Human and Environmental Studies, Nursing, and Law School. Over eleven thousands students are currently learning in our university. By the way, my major is the geotechnical engineering, and I belong to the faculty of Sciences and Engineering in my university. Prof. T. Yamada, here, is my colleague in the same faculty. I know that the nuclear physics is one of the most active academic fields in the world. In fact, about half of the participants, namely, more than 50 scientists, come from abroad in this conference. Moreover, I know that the nuclear physics is related to not only the other fundamental physics such as the elementary particle physics and astrophysics but also chemistry, medical sciences, medical cares, and radiation metrology

22 CFR 192.23 - Administration of benefits.

Code of Federal Regulations, 2010 CFR

2010-04-01

....23 Foreign Relations DEPARTMENT OF STATE HOSTAGE RELIEF VICTIMS OF TERRORISM COMPENSATION Application.... (a) The Director General of the Department of State or Agency Head will issue certifications or other... State or Agency Head shall whenever possible promptly inform the chief legal officer of each U.S. State...

Japan-U.S. Relations: Issues for Congress

DTIC Science & Technology

2009-11-25

22 Insurance ...accelerated its longstanding efforts to become a permanent member of the United Nations Security Council by forming a coalition with Germany , India... Insurance Market access in Japan for U.S. and other foreign insurance providers has been the subject of bilateral trade agreements and discussion for some

Child Development and Childcare in Japan

ERIC Educational Resources Information Center

Anme, Tokie; Segal, Uma A.

2010-01-01

With increasing numbers of women joining the workforce, there is a need for quality childcare. This project, conducted in Japan and using a large number of participants, sought to standardize an evaluation scale to measure the development of children. The development of children under six years of age (N = 22,819) who are enrolled in childcare…

Marine Corps Equities in the Arctic

DTIC Science & Technology

2013-04-18

reduces the shipping time from Yokohama, Japan, to Hamburg , Germany, by 11 days as compared to the Suez Canal. Ships average approximately a 20...areas within the Arctic Circle. 10 Warming ocean water is causing fisheries to shift north as well. Fish populations usually found in the...people live in the Arctic region. Commercial fishing fleets are following these populations. 29 Russia holds the majority of the Arctic population

TOP500 Supercomputers for June 2003

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strohmaier, Erich; Meuer, Hans W.; Dongarra, Jack

2003-06-23

21st Edition of TOP500 List of World's Fastest Supercomputers Released MANNHEIM, Germany; KNOXVILLE, Tenn.;&BERKELEY, Calif. In what has become a much-anticipated event in the world of high-performance computing, the 21st edition of the TOP500 list of the world's fastest supercomputers was released today (June 23, 2003). The Earth Simulator supercomputer built by NEC and installed last year at the Earth Simulator Center in Yokohama, Japan, with its Linpack benchmark performance of 35.86 Tflop/s (teraflops or trillions of calculations per second), retains the number one position. The number 2 position is held by the re-measured ASCI Q system at Los Alamosmore » National Laboratory. With 13.88 Tflop/s, it is the second system ever to exceed the 10 Tflop/smark. ASCIQ was built by Hewlett-Packard and is based on the AlphaServerSC computer system.« less

Academic Profession's Challenge to the Construction of Educational Management in Japan. RIHE International Seminar Reports. No. 23

ERIC Educational Resources Information Center

Arimoto, Akira

2015-01-01

Active learning is now gradually being adopted in many universities and colleges in Japan. This follows the release of the 2012 Central Council of Education (CCE) report that emphasized the need to introduce active learning and to reinforce educational management in academia. As a result, one of the most important problems in Japan's higher…

Tokyo, Yokohama and Tokoy Bay as seen from STS-58

NASA Image and Video Library

1993-10-30

STS058-103-080 (18 Oct-1 Nov 1993) --- Japan's modern megalopolis is seen in this nadir view in great detail. More than 80 vessels can be seen at the anchorage's in Tokyo Bay. The gardens of the Emperor's Palace are seen in this circular area in the upper left quadrant. Even greater detail of this area was captured in the simultaneous color infrared image acquired during this space shuttle mission. (That photo number is STS058-110-085.)

Human T-lymphotropic virus type 1 (HTLV-1) genetic typing in Kakeroma Island, an island at the crossroads of the ryukyuans and Wajin in Japan, providing further insights into the origin of the virus in Japan.

PubMed

Eguchi, Katsuyuki; Fujii, Hidefumi; Oshima, Kengo; Otani, Masashi; Matsuo, Toshiaki; Yamamoto, Taro

2009-08-01

Peripheral blood samples were collected from 23 human T-lymphotropic virus type-1 (HTLV-1) carriers residing in Kakeroma Island, Japan (Kagoshima Prefecture, Oshima County, Setouchi Town), one of the most highly endemic areas in Japan. The samples were subjected to amplification by PCR and sequencing of the Long Terminal Repeat in order to reconstruct a phylogenetic tree of HTLV-1 isolates. Restriction Fragment Length Polymorphism (RFLP) analysis of env region was also conducted for subgrouping of HTLV-1. Although one sample could not be amplified by PCR, and three more could not be sequenced due to the existence of conspicuous nonspecific bands or repeated sequences, the phylogenetic analysis revealed that the remaining 19 isolates obtained from Kakeroma Island belonged to either the Transcontinental or the Japanese subgroups of the Cosmopolitan subtype, one of the three major subtypes. The RFLP data corresponded closely with the typing data throughout the sequencing. The proportion of the Transcontinental subgroup among the isolates was 26.3% (5 of 19) by sequence analysis and 27.3% (6 of 22) by RFLP. Unlike in Taiwan, China and Okinawa, the Japanese subgroup was dominant in Kakeroma Island. The analysis would also suggest that the Japanese subgroup seems not to have derived from the Transcontinental subgroup, but rather that the Transcontinental subgroup came to Japan first and was followed later by the Japanese one. 2009 Wiley-Liss, Inc.

Japan.

PubMed

1987-02-01

Japan is composed of 4 main islands and more than 3900 smaller islands and has 317.7 persons/square kilometer. This makes it one of the most densely populated nations in the world. Religion is an important force in the life of the Japanese and most consider themselves Buddhists. Schooling is free through junior high but 90% of Japanese students complete high school. In fact, Japan enjoys one of the highest literacy rates in the world. There are over 178 newspapers and 3500 magazines published in Japan and the number of new book titles issued each year is greater than that in the US. Since WW1, Japan expanded its influence in Asia and its holdings in the Pacific. However, as a direct result of WW2, Japan lost all of its overseas possessions and was able to retain only its own islands. Since 1952, Japan has been ruled by conservative governments which cooperate closely with the West. Great economic growth has come since the post-treaty period. Japan as a constitutional monarchy operates within the framework of a constitution which became effective in May 1947. Executive power is vested in a cabinet which includes the prime minister and the ministers of state. Japan is one of the most politically stable of the postwar democracies and the Liberal Democratic Party is representative of Japanese moderate conservatism. The economy of Japan is strong and growing. With few resources, there is only 19% of Japanese land suitable for cultivation. Its exports earn only about 19% of the country's gross national product. More than 59 million workers comprise Japan's labor force, 40% of whom are women. Japan and the US are strongly linked trading partners and after Canada, Japan is the largest trading partner of the US. Foreign policy since 1952 has fostered close cooperation with the West and Japan is vitally interested in good relations with its neighbors. Relations with the Soviet Union are not close although Japan is attempting to improve the situation. US policy is based on

Detection of Rickettsia and Ehrlichia spp. in Ticks Associated with Exotic Reptiles and Amphibians Imported into Japan.

PubMed

Andoh, Masako; Sakata, Akiko; Takano, Ai; Kawabata, Hiroki; Fujita, Hiromi; Une, Yumi; Goka, Koichi; Kishimoto, Toshio; Ando, Shuji

2015-01-01

One of the major routes of transmission of rickettsial and ehrlichial diseases is via ticks that infest numerous host species, including humans. Besides mammals, reptiles and amphibians also carry ticks that may harbor Rickettsia and Ehrlichia strains that are pathogenic to humans. Furthermore, reptiles and amphibians are exempt from quarantine in Japan, thus facilitating the entry of parasites and pathogens to the country through import. Accordingly, in the current study, we examined the presence of Rickettsia and Ehrlichia spp. genes in ticks associated with reptiles and amphibians originating from outside Japan. Ninety-three ticks representing nine tick species (genera Amblyomma and Hyalomma) were isolated from at least 28 animals spanning 10 species and originating from 12 countries (Ghana, Jordan, Madagascar, Panama, Russia, Sri Lanka, Sudan, Suriname, Tanzania, Togo, Uzbekistan, and Zambia). None of the nine tick species are indigenous in Japan. The genes encoding the common rickettsial 17-kDa antigen, citrate synthase (gltA), and outer membrane protein A (ompA) were positively detected in 45.2% (42/93), 40.9% (38/93), and 23.7% (22/93) of the ticks, respectively, by polymerase chain reaction (PCR). The genes encoding ehrlichial heat shock protein (groEL) and major outer membrane protein (omp-1) were PCR-positive in 7.5% (7/93) and 2.2% (2/93) of the ticks, respectively. The p44 gene, which encodes the Anaplasma outer membrane protein, was not detected. Phylogenetic analysis showed that several of the rickettsial and ehrlichial sequences isolated in this study were highly similar to human pathogen genes, including agents not previously detected in Japan. These data demonstrate the global transportation of pathogenic Rickettsia and Ehrlichia through reptile- and amphibian-associated ticks. These imported animals have potential to transfer pathogens into human life. These results highlight the need to control the international transportation of known and

Detection of Rickettsia and Ehrlichia spp. in Ticks Associated with Exotic Reptiles and Amphibians Imported into Japan

PubMed Central

Andoh, Masako; Sakata, Akiko; Takano, Ai; Kawabata, Hiroki; Fujita, Hiromi; Une, Yumi; Goka, Koichi; Kishimoto, Toshio; Ando, Shuji

2015-01-01

One of the major routes of transmission of rickettsial and ehrlichial diseases is via ticks that infest numerous host species, including humans. Besides mammals, reptiles and amphibians also carry ticks that may harbor Rickettsia and Ehrlichia strains that are pathogenic to humans. Furthermore, reptiles and amphibians are exempt from quarantine in Japan, thus facilitating the entry of parasites and pathogens to the country through import. Accordingly, in the current study, we examined the presence of Rickettsia and Ehrlichia spp. genes in ticks associated with reptiles and amphibians originating from outside Japan. Ninety-three ticks representing nine tick species (genera Amblyomma and Hyalomma) were isolated from at least 28 animals spanning 10 species and originating from 12 countries (Ghana, Jordan, Madagascar, Panama, Russia, Sri Lanka, Sudan, Suriname, Tanzania, Togo, Uzbekistan, and Zambia). None of the nine tick species are indigenous in Japan. The genes encoding the common rickettsial 17-kDa antigen, citrate synthase (gltA), and outer membrane protein A (ompA) were positively detected in 45.2% (42/93), 40.9% (38/93), and 23.7% (22/93) of the ticks, respectively, by polymerase chain reaction (PCR). The genes encoding ehrlichial heat shock protein (groEL) and major outer membrane protein (omp-1) were PCR-positive in 7.5% (7/93) and 2.2% (2/93) of the ticks, respectively. The p44 gene, which encodes the Anaplasma outer membrane protein, was not detected. Phylogenetic analysis showed that several of the rickettsial and ehrlichial sequences isolated in this study were highly similar to human pathogen genes, including agents not previously detected in Japan. These data demonstrate the global transportation of pathogenic Rickettsia and Ehrlichia through reptile- and amphibian-associated ticks. These imported animals have potential to transfer pathogens into human life. These results highlight the need to control the international transportation of known and

Japan.

PubMed

1989-02-01

Japan consists of 3900 islands and lies off the east coast of Asia. Even though Japan is one of the most densely populated nations in the world, its growth rate has stabilized at .5%. 94% of all children go to senior high school and almost 90% finish. Responsibility for the sick, aged, and infirmed is changing from the family and private sector to government. Japan was founded in 600 BC and its 1st capital was in Nara (710-1867). The Portuguese, the 1st Westerners to make contact with Japan in 1542, opened trade which lasted until the mid 17th century. US Navy Commodore Matthew Perry forced Japan to reopen in 1854. Following wars with China and Russia in the late 1800s and early 1900s respectively, Japan took part in World Wars I and II. In between these wars Japan invaded Manchuria and China. The US dropped an atomic bomb on Hiroshima and Nagasaki and the Japanese surrendered in September, 1945 ending World War II (WWII). Following, WWII, the Allied Powers guided Japan's establishment as a nonthreatening nation and a democratic parliamentary government (a constitutional monarchy) with a limited defense force. Japan remains one of the most politically stable of all postwar democracies. The Liberal Democratic Party's Noboru Takeshita became prime minister in 1987. Japan has limited natural resources and only 19% of the land is arable. Japanese ingenuity and skill combine to produce one of the highest per hectare crop yields in the world. Japan is a major economic power, and its and the US economies are becoming more interdependent. Its exports, making up only 13% of the gross national product, mainly go to Canada and the US. Many in the US are concerned, however, with the trade deficit with Japan and are seeking ways to make trade more equitable. Japan wishes to maintain good relations with its Asian neighbors and other nations. The US and Japan enjoy a strong, productive relationship.

Nuclear reaction rate uncertainties and the 22Ne( p,gamma)23Na reaction: Classical novae and globular clusters

NASA Astrophysics Data System (ADS)

Kelly, Keegan John

The overall theme of this thesis is the advancement of nuclear astrophysics via the analysis of stellar processes in the presence of varying levels of precision in the available nuclear data. With regard to classical novae, the level of mixing that occurs between the outer layers of the white dwarf core and the solar accreted material in oxygen-neon novae is presently undetermined by stellar models, but the nuclear data relevant to these explosive phenomena are fairly precise. This precision allowed for the identification of a series of elemental ratios indicative of the level of mixing occurring in novae. Direct comparisons of the modelled elemental ratios to observations showed that there is likely to be much less of this mixing than was previously assumed. Thus, our understanding of classical novae was altered via the investigation of the nuclear reactions relevant to this phenomenon. However, this level of experimental precision is rare and large nuclear reaction uncertainties can hinder our understanding of certain astrophysical phenomena. For example, it is commonly believed that uncertainties in the 22Ne(p,g)23Na reaction rate at temperatures relevant to thermally-pulsing asymptotic giant branch stars are largely responsible for our inability to explain the observed sodium-oxygen anti-correlation in globular clusters. With this motivation, resonances in the 22Ne(p,g) 23Na reaction at E_{c.m.} = 458, 417, 178, and 151 keV were measured. The direct-capture contribution was also measured at E_{lab} = 425 keV. It was determined that the 22Ne(p,g)23Na reaction rate in the astrophysically relevant temperature range is dominated by the resonances at 178 and 151 keV and that the total reaction rate is greater than the previously assumed rate by a factor of approximately ˜40 at 0.15 GK. This increased reaction rate impacts the expected nucleosynthesis that occurs in these stars and will shed light onto the origin of this anti-correlation as it is incorporated into

Inhibition of TYK2 and JAK1 Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis by Inhibiting IL-22 and the IL-23/IL-17 axis

PubMed Central

Works, Melissa G.; Yin, Fangfang; Yin, Catherine C.; Yiu, Ying; Shew, Kenneth; Tran, Thanh-Thuy; Dunlap, Nahoko; Lam, Jennifer; Mitchell, Tim; Reader, John; Stein, Paul L.; D’Andrea, Annalisa

2014-01-01

Psoriasis is a chronic autoimmune disease affecting the skin and characterized by aberrant keratinocyte proliferation and function. Immune cells infiltrate the skin and release proinflammatory cytokines that play important roles in psoriasis. The Th17 network, including IL-23 and IL-22, has recently emerged as a critical component in the pathogenesis of psoriasis. IL-22 and IL-23 signaling is dependent on the JAK family of protein tyrosine kinases, making Janus kinase (JAK) inhibition an appealing strategy for the treatment of psoriasis. Here we report the activity of SAR-20347, a small molecule inhibitor with specificity for JAK1 and Tyrosine Kinase 2 (TYK2) over other JAK family members. In cellular assays, SAR-20347 dose-dependently (1 nM-10 μM) inhibited JAK1 and/or TYK2 dependent signaling from the IL-12/IL-23, IL-22, and IFN-α receptors. In vivo, TYK2 mutant mice or treatment of wild type mice with SAR-20347 significantly reduced IL-12 induced IFN-γ production and IL-22-dependent Serum Amyloid A (SAA) to similar extents, indicating that in these models, SAR-20347 is probably acting through inhibition of TYK2. In an imiquimod-induced psoriasis model, the administration of SAR-20347 led to a striking decrease in disease pathology, including reduced activation of keratinocytes, and proinflammatory cytokine levels compared to both TYK2 mutant mice and wild type controls. Taken together, these data indicate that targeting both JAK1 and TYK2-mediated cytokine signaling is more effective than TYK2 inhibition alone in reducing psoriasis pathogenesis. PMID:25156366

Japan’s Emerging Role as an Asian-Pacific Power.

DTIC Science & Technology

1986-06-01

34Nakasone’s External Policy." Asia Pacfic Community 25 (Summer 1984): 28-40. 114. Colbert , Evelyn. "Japan and the Republic of Korea." Asian Survey 3...129. The Korea Herald, May 7, 1985. 129 130. Jo, Yung-hwan. "Two Koreas Unification." Asia Pacific Community 23 (Winter 1984): 75-85. 131. Colbert ...Pacific Community 25 (Summer 1984): 51-57. 179. Reischauer, Edwin 0. The United States and Japan. New York: The Viking Press, Inc., 1968. 133 . r

Pinonaldehyde and some other organics in rain and snow in central Japan.

PubMed

Satsumabayashi, H; Nishizawa, H; Yokouchi, Y; Ueda, H

2001-11-01

Solvent-extractable organic compounds in the rain and snow collected at local cities in the mountainous region in central Japan, were analyzed by GC/MS and GC. Pinonaldehyde (2,2-dimethyl-3-acetyl-cyclobutyl-ethanal), an atmospheric reaction product of alpha-pinene, was detected in the rain and snow for the first time, and n-alkanes (C17-C33), fatty acids (C8-C23), and benzoic acid were also detected as major organic components. Concentrations of pinonaldehyde, C17-C33 n-alkanes, C8-C11 fatty acids, C12-C23 fatty acids and benzoic acid ranged between <0.02-13, 0.10-35, 0.55-5.7, 4.2-19 and <0.02-6.0 microg/l, respectively. Their composition showed some difference in summer and winter. In summer, fatty acids and benzoic acid were more abundant, while pinonaldehyde and n-alkanes were much less. Higher photochemical reactivity and higher bioactivity in summer could explain these seasonal changes except for pinonaldehyde, which would suffer from further oxidation in the atmosphere after its photochemical production from alpha-pinene. Predominance of pinonaldehyde and C12-C23 fatty acids in the rain and snow showed a remarkable contrast to n-alkanes in aerosol phase, which were the most abundant components. It indicated that oxygenated products from biogenic compounds might be important as cloud condensation nuclei in forest areas.

An early solar dynamo prediction: Cycle 23 is approximately cycle 22

NASA Technical Reports Server (NTRS)

Schatten, Kenneth H.; Pesnell, W. Dean

1993-01-01

In this paper, we briefly review the 'dynamo' and 'geomagnetic precursor' methods of long-term solar activity forecasting. These methods depend upon the most basic aspect of dynamo theory to predict future activity, future magnetic field arises directly from the magnification of pre-existing magnetic field. We then generalize the dynamo technique, allowing the method to be used at any phase of the solar cycle, through the development of the 'Solar Dynamo Amplitude' (SODA) index. This index is sensitive to the magnetic flux trapped within the Sun's convection zone but insensitive to the phase of the solar cycle. Since magnetic fields inside the Sun can become buoyant, one may think of the acronym SODA as describing the amount of buoyant flux. Using the present value of the SODA index, we estimate that the next cycle's smoothed peak activity will be about 210 +/- 30 solar flux units for the 10.7 cm radio flux and a sunspot number of 170 +/- 25. This suggests that solar cycle #23 will be large, comparable to cycle #22. The estimated peak is expected to occur near 1999.7 +/- 1 year. Since the current approach is novel (using data prior to solar minimum), these estimates may improve when the upcoming solar minimum is reached.

Toward an Arctic Strategy

DTIC Science & Technology

2009-02-01

Arctic Sea Ice Extent6 Reduced ice pack area translates to less reflected solar energy, which further accelerates the ongoing melting process . Light... process , creating a vicious cycle where melting ice causes the remaining ice to melt faster.7 Modelers previously agreed that the Arctic Ocean could be...freight ports stand to benefit by shipping through the Arctic region.10 For example, an ocean voyage from Yokohama, Japan, to Hamburg, Germany via the

A de novo 1q22q23.1 Interstitial Microdeletion in a Girl with Intellectual Disability and Multiple Congenital Anomalies Including Congenital Heart Defect.

PubMed

Aleksiūnienė, Beata; Preiksaitiene, Egle; Morkūnienė, Aušra; Ambrozaitytė, Laima; Utkus, Algirdas

2018-01-01

Many studies have shown that molecular karyotyping is an effective diagnostic tool in individuals with developmental delay/intellectual disability. We report on a de novo interstitial 1q22q23.1 microdeletion, 1.6 Mb in size, detected in a patient with short stature, microcephaly, hypoplastic corpus callosum, cleft palate, minor facial anomalies, congenital heart defect, camptodactyly of the 4-5th fingers, and intellectual disability. Chromosomal microarray analysis revealed a 1.6-Mb deletion in the 1q22q23.1 region, arr[GRCh37] 1q22q23.1(155630752_157193893)×1. Real-time PCR analysis confirmed its de novo origin. The deleted region encompasses 50 protein-coding genes, including the morbid genes APOA1BP, ARHGEF2, LAMTOR2, LMNA, NTRK1, PRCC, RIT1, SEMA4A, and YY1AP1. Although the unique phenotype observed in our patient can arise from the haploinsufficiency of the dosage-sensitive LMNA gene, the dosage imbalance of other genes implicated in the rearrangement could also contribute to the phenotype. Further studies are required for the delineation of the phenotype associated with this rare chromosomal alteration and elucidation of the critical genes for manifestation of the specific clinical features. © 2018 S. Karger AG, Basel.

Epidemiological patterns of traumatic musculoskeletal injuries and non-traumatic disorders in Japan Self-Defense Forces.

PubMed

Amako, Masatoshi; Yato, Yoshiyuki; Yoshihara, Yasuo; Arino, Hiroshi; Sasao, Hiroshi; Nemoto, Osamu; Imai, Tomohito; Sugihara, Atsushi; Tsukazaki, Satoshi; Sakurai, Yutaka; Nemoto, Koichi

2018-05-01

The epidemiological patterns of musculoskeletal injuries or disorders in military personnel have not been well documented and a better understanding is required for proper preventative measures and treatment. Here, we investigated musculoskeletal injuries or disorders among members of the Japan Self-Defense Forces. All orthopedic patients (n = 22,340) who consulted to Japan Self-Defense Forces Hospitals were investigated for their type of injury or disorder, the injured body part, the mechanism, and the cause of injuries. Thirty-nine percent of the cases were classified as traumatic injuries, and 61% were classified as non-traumatic disorders. Of the traumatic injury patients, the injured body part was the upper extremity in 32%, the trunk in 23%, and the lower extremities in 45% of the cases. The most common injured body location was the knee followed by the hand/finger and ankle. Exercise was the most common cause of injury, followed by traffic accident and military training. Contusions were the most common traumatic injuries, followed by sprains and fractures. Of non-traumatic disorders, the lower extremities were reported as the injured part in 43% of the disorders. Lumbar spine disorders were the most common non-traumatic disorders, followed by tendon and joint disorders. Over one-third of orthopedic cases among members of the Japan Self-Defense Forces are traumatic injuries, with the knee being the body part most commonly injured and exercise being the leading cause of injury.

Neonatal outcomes of extremely preterm infants from taiwan: comparison with Canada, Japan, and the USA.

PubMed

Su, Bai-Horng; Hsieh, Wu-Shiun; Hsu, Chyong-Hsin; Chang, Jui-Hsing; Lien, Reyin; Lin, Chyi-Her

2015-02-01

This study compared the current trend in survival rates and morbidity for very low birth weight (VLBW) infants in five Medical Training Centers of Prematurity for the Premature Baby Foundation of Taiwan (PBFT), with the outcomes from the USA, National Institute of Child Health and Human Development Neonatal Research Network (NICHD NRN), the Canadian Neonatal Network (CNN), and the Neonatal Research Network of Japan (NRNJ). The survival rates of VLBW infants according to gestational age (GA) and major morbidities were compared between networks (Taiwan, USA, Canada, and Japan). Taiwanese data for VLBW infants of GA ≤28 weeks between 2007 and 2012 were obtained from the "PBFT Annual Conferences of Premature Care" reports defining survival rate as neonates that survived to the time of discharge. Major morbidities included severe neurological injury (Grade 3 or 4 intraventricular hemorrhage or periventricular leukomalacia), bronchopulmonary dysplasia, severe retinopathy of prematurity, necrotizing enterocolitis, late-onset sepsis, and patent ductus arteriosus. The survival rates of VLBW infants of GA ≤28 weeks from the PBFT (Taiwan), NICHD NRN (USA), CNN (Canada), and NRNJ (Japan) were 77% (1323/1718), 72% (6859/9575), 82% (2353/2872), and 89% (4489/5069), respectively. The annual survival rates in Taiwan from 2007 to 2012 were 72%, 76%, 76%, 74%, 77%, and 78%, respectively. When GA from ≤23 weeks to 28 weeks was assessed in Taiwan, the survival rates of VLBW infants according to each week were 22%, 50%, 70%, 80%, 88%, and 92%, respectively. The survival rate, especially at lower GAs, was highest in the NRNJ (Japan). The major difference between Taiwan and Japan was attributed to the lower survival rates at lower GA (≤26 weeks) in Taiwan. Japan had the lowest rates of major morbidities among the four countries. The survival rate of VLBW infants has improved over the past 6 years in Taiwan. It is higher than the USA, but lower than Canada and Japan. However, the

7 CFR 915.23 - Selection.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Selection. 915.23 Section 915.23 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Regulating Handling Administrative Body § 915.23 Selection. From the nominations made pursuant to § 915.22...

7 CFR 924.23 - Selection.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Selection. 924.23 Section 924.23 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements....23 Selection. From the nominations made pursuant to § 924.22, or from other qualified persons, the...

7 CFR 916.23 - Selection.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Selection. 916.23 Section 916.23 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Regulating Handling Administrative Body § 916.23 Selection. From the nominations made pursuant to § 916.22...

Pseudo Jahn-Teller coupling in trioxides XO3(0,1,-1) with 22 and 23 valence electrons

NASA Astrophysics Data System (ADS)

Grein, Friedrich

2013-05-01

D3h and C2v geometries and energies, vertical excitation energies, as well as minimal energy paths as function of the O1(z)-X-O2 angle α were obtained for XO3(0,1,-1) (X = B, Al, Ga; C, Si, Ge; N, P, As; S, Se) molecules and ions with 22 and 23 valence electrons (VE), using density functional theory (DFT), coupled cluster with single and double substitutions with noniterative triple excitations (CCSD(T)), equation of motion (EOM)-CCSD, time-dependent DFT, and multi-reference configuration interaction methods. It is shown that pseudo Jahn-Teller (PJT) coupling increases as the central atom X becomes heavier, due to decreases in excitation energies. As is well known for CO3, the excited 1E' states of the 22 VE systems SiO3, GeO3; NO_3 ^ +, PO3+, AsO3+; BO3-, AlO3-, GaO3- have strong vibronic coupling with the 1A1' ground state via the e' vibrational modes, leading to a C2v minimum around α = 145°. For first and second row X atoms, there is an additional D3h minimum (α = 120°). Interacting excited states have minima around 135°. In the 23 VE systems CO3-, SiO3-; NO3, PO3; SO3+, coupling of the excited 2E' with the 2A2' ground state via the e' mode does not generate a C2v state. Minima of interacting excited states are close to 120°. However, due to very strong PJT coupling, a double-well potential is predicted for GeO3-, AsO3, and SeO3+, with a saddle point at D3h symmetry. Interaction of the b2 highest occupied molecular orbital with the b2 lowest unoccupied molecular orbital, both oxygen lone pair molecular orbitals, is seen as the reason for the C2v stabilization of 22 VE molecules.

Activities for the Promotion of Gender Equality in Japan—Japan Society of Applied Physics

NASA Astrophysics Data System (ADS)

Kodate, Kashiko; Tanaka, Kazuo

2005-10-01

Since 1946, the Japan Society of Applied Physics (JSAP) has strived to promote research and development in applied physics for benefits beyond national boundaries. Activities of JSAP involve multidisciplinary fields, from physics and engineering to life sciences. Of its 23,000 members, 48% are from industry, 29% from academia, and about 7% from semi-autonomous national research laboratories. Its large industrial membership is one of the distinctive features of JSAP. In preparation for the First IUPAP International Conference on Women in Physics (Paris, 2002), JSAP members took the first step under the strong leadership of then-JSAP President Toshio Goto, setting up the Committee for the Promotion Equal Participation of Men and Women in Science and Technology. Equality rather than women's advancement is highlighted to further development in science and technology. Attention is also paid to balancing the number of researchers from different age groups and affiliations. The committee has 22 members: 12 female and 10 male; 7 from corporations, 12 from universities, and 3 from semi-autonomous national research institutes. Its main activities are to organize symposia and meetings, conduct surveys among JSAP members, and provide child-care facilities at meetings and conferences. In 2002 the Japan Physics Society and the Chemical Society of Japan jointly created the Japan Inter-Society Liaison Association for the Promotion of Equal Participation of Men and Women in Science and Engineering. Membership has grown to 44 societies (of which 19 are observers) ranging from mathematics, information, and life sciences to civil engineering. Joint activities across sectors and empower the whole. The Gender Equality Bureau in the Cabinet Office recently launched a large-scale project called "Challenge Campaign" to encourage girls to major in natural science and engineering, which JSAP is co-sponsoring.

Childhood-onset schizophrenia case with 2.2 Mb deletion at chromosome 3p12.2-p12.1 and two large chromosomal abnormalities at 16q22.3-q24.3 and Xq23-q28.

PubMed

Rudd, Danielle; Axelsen, Michael; Epping, Eric A; Andreasen, Nancy; Wassink, Thomas

2015-04-01

Childhood-onset schizophrenia is rare, comprising 1% of known schizophrenia cases. Here, we report a patient with childhood-onset schizophrenia who has three large chromosomal abnormalities: an inherited 2.2 Mb deletion of chromosome 3p12.2-p12.1, a de novo 16.7 Mb duplication of 16q22.3-24.3, and a de novo 43 Mb deletion of Xq23-q28.

The structure of Al-23 and astrophysical consequences

NASA Astrophysics Data System (ADS)

Zhai, Yongjun

Motivated by existing nuclear astrophysics problems, the b-decay of the proton rich nucleus 23 Al was studied for the first time with pure samples which were obtained by using the 1 H( 24 Mg, 23 Al)2n reaction and the MARS recoil separator at Texas A&M University. b and b-g coincidence measurements were made with a fast tape-transport system, scintillator, BGO and HPGe g detectors. The experiment allowed us to measure absolute b branching ratios and to determine log ft values for transitions to final states in 23 Mg, including the isobaric analog state (IAS), and, therefore, to determine unambiguously the spin and parity of the 23 Al ground state to be J p = 5/2 + . This work excludes the large increases in the radiative proton capture cross section for the reaction 22 Mg(p,g) 23 Al at astrophysical energies, which were implied by claims that the spin and parity of the 23 Al ground state were J p = 1/2 + . More precise half life and mass determinations of 23 Al were obtained from the experimental data. The log ft for the Fermi transition to its isobaric analog state in 23 Mg was also determined for the first time. This IAS and a state 16 keV below it were observed, well separated in the same experiment for the first time. The b- decay scheme of the proton rich nucleus 23 Al was established. We can now solve a number of inconsistencies in the literature, exclude strong isospin mixing claimed before, and obtain a new determination of the resonance strength. The IAS and the state 16 keV below it are resonances in the 22 Na(p,g) 23 Mg reaction at energies that are important in novae. This second state turns out to be the resonance that gives the most important contribution in the depletion of 22Na from novae. Both of the reactions of 22 Mg(p,g) 23 Al and 22 Na(p,g) 23 Mg have been suggested as possible candidates for diverting some of the flux in oxygen-neon novae explosions from the A=22 into the A=23 mass chain.

40 CFR 264.231 - Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27.

Code of Federal Regulations, 2013 CFR

2013-07-01

... wastes FO20, FO21, FO22, FO23, FO26, and FO27. 264.231 Section 264.231 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Surface Impoundments § 264.231 Special...

40 CFR 264.317 - Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27.

Code of Federal Regulations, 2013 CFR

2013-07-01

... wastes FO20, FO21, FO22, FO23, FO26, and FO27. 264.317 Section 264.317 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Landfills § 264.317 Special requirements for...

40 CFR 264.317 - Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27.

Code of Federal Regulations, 2012 CFR

2012-07-01

... wastes FO20, FO21, FO22, FO23, FO26, and FO27. 264.317 Section 264.317 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Landfills § 264.317 Special requirements for...

40 CFR 264.231 - Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27.

Code of Federal Regulations, 2012 CFR

2012-07-01

... wastes FO20, FO21, FO22, FO23, FO26, and FO27. 264.231 Section 264.231 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Surface Impoundments § 264.231 Special...

40 CFR 264.231 - Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27.

Code of Federal Regulations, 2014 CFR

2014-07-01

... wastes FO20, FO21, FO22, FO23, FO26, and FO27. 264.231 Section 264.231 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Surface Impoundments § 264.231 Special...

40 CFR 264.317 - Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27.

Code of Federal Regulations, 2014 CFR

2014-07-01

... wastes FO20, FO21, FO22, FO23, FO26, and FO27. 264.317 Section 264.317 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Landfills § 264.317 Special requirements for...

40 CFR 264.283 - Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27.

Code of Federal Regulations, 2011 CFR

2011-07-01

... wastes FO20, FO21, FO22, FO23, FO26, and FO27. 264.283 Section 264.283 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Land Treatment § 264.283 Special requirements...

40 CFR 264.283 - Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27.

Code of Federal Regulations, 2014 CFR

2014-07-01

... wastes FO20, FO21, FO22, FO23, FO26, and FO27. 264.283 Section 264.283 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Land Treatment § 264.283 Special requirements...

40 CFR 264.283 - Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27.

Code of Federal Regulations, 2013 CFR

2013-07-01

... wastes FO20, FO21, FO22, FO23, FO26, and FO27. 264.283 Section 264.283 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Land Treatment § 264.283 Special requirements...

40 CFR 264.283 - Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27.

Code of Federal Regulations, 2012 CFR

2012-07-01

... wastes FO20, FO21, FO22, FO23, FO26, and FO27. 264.283 Section 264.283 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Land Treatment § 264.283 Special requirements...

An Evidence-Based Systematic Review of Beta-Sitosterol, Sitosterol (22,23- dihydrostigmasterol, 24-ethylcholesterol) by the Natural Standard Research Collaboration.

PubMed

Ulbricht, Catherine E

2016-01-01

An evidence-based systematic review of beta-sitosterol, sitosterol (22,23-dihydrostigmasterol, 24-ethylcholesterol) by the Natural Standard Research Collaboration consolidates the safety and efficacy data available in the scientific literature using a validated, reproducible grading rationale. This article includes written and statistical analysis of clinical trials, plus a compilation of expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.

7 CFR 920.23 - Selection.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Selection. 920.23 Section 920.23 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Administrative Body § 920.23 Selection. From the nominations made pursuant to § 920.22, or from other qualified...

Tremor Hypocenters Form a Narrow Zone at the Plate Interface in Two Areas of SW Japan

NASA Astrophysics Data System (ADS)

Armbruster, J. G.

2015-12-01

The tremor detectors developed for accurately locating tectonic tremor in Cascadia [Armbruster et al., JGR 2014] have been applied to data from the HINET seismic network in Japan. In the overview by Obara [Science 2002] there are three strong sources of tectonic tremor in southwest Japan: Shikoku, Kii Pen. and Tokai. The daily epicentral distributions of tremor on the HINET web site allow the identification of days when tremor in each source is active. The worst results were obtained in Shikoku, in spite of the high level of tremor activity observed there by others. This method requires a clear direct arrival of the S and P waves at the stations for coherence to be seen, so scattering and shear wave splitting are possible reasons for poor results there. Relatively wide station spacing, 19-30 km, is another possible reason. The best results were obtained in Tokai with stations STR, HRY and TYE spacing 18-19 km, and Kii Pen. with stations KRT, HYS and KAW spacing 15-22 km. In both of those areas the three station detectors see strong episodes of tremor. If detections with three stations are located by constraining them to the plate interface, a pattern of persistent sources is seen, with some intense sources. This is similar to what was seen in Cascadia. Detections with four stations give S and P arrival times of high accuracy. In Tokai the hypocenters form a narrow, 2-3 km thick, zone dipping to the north, consistent with the plate interface there. In Kii Pen. the hypocenters dip to the northwest in a thin, 2-3 km thick, zone but approximately 5 km shallower than a plate interface model for this area [Yoshioka and Murakami, GJI 2007]. The overlap of tremor sources in the 12 years analyzed here suggests relative hypocentral location errors as small as 2-3 km. We conclude that the methods developed in Cascadia will work in Japan but the typical spacing of HINET stations, ~20 km, is greater than the optimum distance found in analysis of data from Cascadia, 8 to 15 km.

Delays in clinical development of neurological drugs in Japan.

PubMed

Ikeda, Masayuki

2017-06-28

The delays in the approval and development of neurological drugs between Japan and other countries have been a major issue for patients with neurological diseases. The objective of this study was to analyze factors contributing to the delay in the launching of neurological drugs in Japan. We analyzed data from Japan and the US for the approval of 42 neurological drugs, all of which were approved earlier in the US than in Japan, and examined the potential factors that may cause the delay of their launch. Introductions of the 42 drugs in Japan occurred at a median of 87 months after introductions in the US. The mean review time of new drug applications for the 20 drugs introduced in Japan in January 2011 or later (15 months) was significantly shorter than that for the other 22 drugs introduced in Japan in December 2010 or earlier (24 months). The lag in the Japan's review time behind the US could not explain the approval delays. In the 31 of the 42 drugs, the application data package included overseas data. The mean review time of these 31 drugs (17 months) was significantly shorter than that of the other 11 drugs without overseas data (26 months). The mean approval lag behind the US of the 31 drugs (78 months) was also significantly shorter than that of the other 11 drugs (134 months). These results show that several important reforms in the Japanese drug development and approval system (e.g., inclusion of global clinical trial data) have reduced the delays in the clinical development of neurological drugs.

Economic Evaluation of Immunisation Programme of 23-Valent Pneumococcal Polysaccharide Vaccine and the Inclusion of 13-Valent Pneumococcal Conjugate Vaccine in the List for Single-Dose Subsidy to the Elderly in Japan.

PubMed

Hoshi, Shu-ling; Kondo, Masahide; Okubo, Ichiro

2015-01-01

Currently in Japan, both 23-valent pneumococcal polysaccharide vaccine (PPSV-23) and 13-valent pneumococcal conjugate vaccine (PCV-13) are available for the elderly for the prevention of S. pneumoniae-related diseases. PPSV-23 was approved in 1988, while the extended use of PCV-13 was approved for adults aged 65 and older in June 2014. Despite these two vaccines being available, the recently launched national immunisation programme for the elderly only subsidised PPSV-23. The framework of the current immunisation programme lasts for five years. The elderly population eligible for the subsidised PPSV-23 shot for the 1st year are those aged 65, 70, 75, 80, 85, 90, 95 and ≥ 100. While from the 2nd year to the 5th year, those who will age 65, 70, 75, 80, 85, 90, 95 and 100 will receive the same subsidised shot. We performed economic evaluations to (1) evaluate the efficiency of alternative strategies of PPSV-23 single-dose immunisation programme, and (2) investigate the efficiency of PCV-13 inclusion in the list for single-dose pneumococcal vaccine immunisation programme. Three alternative strategies were created in this study, namely: (1) current PPSV-23 strategy, (2) 65 to 80 (as "65-80 PPSV-23 strategy"), and (3) 65 and older (as "≥ 65 PPSV-23 strategy"). We constructed a Markov model depicting the S. pneumoniae-related disease course pathways. The transition probabilities, utility weights to estimate quality adjusted life year (QALY) and disease treatment costs were either calculated or cited from literature. Cost of per shot of vaccine was ¥ 8,116 (US$74; US$1 = ¥ 110) for PPSV-23 and ¥ 10,776 (US$98) for PCV-13. The model runs for 15 years with one year cycle after immunisation. Discounting was at 3%. Compared to current PPSV-23 strategy, 65-80 PPSV-23 strategy cost less but gained less, while the incremental cost-effectiveness ratios (ICERs) of ≥ 65 PPSV-23 strategy was ¥ 5,025,000 (US$45,682) per QALY gained. PCV-13 inclusion into the list for single

Economic Evaluation of Immunisation Programme of 23-Valent Pneumococcal Polysaccharide Vaccine and the Inclusion of 13-Valent Pneumococcal Conjugate Vaccine in the List for Single-Dose Subsidy to the Elderly in Japan

PubMed Central

Hoshi, Shu-ling; Kondo, Masahide; Okubo, Ichiro

2015-01-01

Background Currently in Japan, both 23-valent pneumococcal polysaccharide vaccine (PPSV–23) and 13-valent pneumococcal conjugate vaccine (PCV–13) are available for the elderly for the prevention of S. pneumoniae-related diseases. PPSV–23 was approved in 1988, while the extended use of PCV–13 was approved for adults aged 65 and older in June 2014. Despite these two vaccines being available, the recently launched national immunisation programme for the elderly only subsidised PPSV–23. The framework of the current immunisation programme lasts for five years. The elderly population eligible for the subsidised PPSV–23 shot for the 1st year are those aged 65, 70, 75, 80, 85, 90, 95 and ≥100. While from the 2nd year to the 5th year, those who will age 65, 70, 75, 80, 85, 90, 95 and 100 will receive the same subsidised shot. Methods We performed economic evaluations to (1) evaluate the efficiency of alternative strategies of PPSV–23 single-dose immunisation programme, and (2) investigate the efficiency of PCV–13 inclusion in the list for single-dose pneumococcal vaccine immunisation programme. Three alternative strategies were created in this study, namely: (1) current PPSV–23 strategy, (2) 65 to 80 (as “65–80 PPSV–23 strategy”), and (3) 65 and older (as “≥65 PPSV–23 strategy”). We constructed a Markov model depicting the S. pneumoniae-related disease course pathways. The transition probabilities, utility weights to estimate quality adjusted life year (QALY) and disease treatment costs were either calculated or cited from literature. Cost of per shot of vaccine was ¥8,116 (US$74; US$1 = ¥110) for PPSV–23 and ¥10,776 (US$98) for PCV–13. The model runs for 15 years with one year cycle after immunisation. Discounting was at 3%. Results Compared to current PPSV–23 strategy, 65–80 PPSV–23 strategy cost less but gained less, while the incremental cost-effectiveness ratios (ICERs) of ≥65 PPSV–23 strategy was ¥5,025,000 (US$45

The U.S., Japan, and Asia: Challenges to U.S. Policy

DTIC Science & Technology

1993-10-01

1945-1990. Cambridge: Cambridge UP, 1992. (E 183.8 .J3 B78 1992) Burks , Ardath W. Japan: A Postindustrial Power. 3rd ed. Boulder: Westview, 1991. (DS 806...1988) Anchordoguy, Marie . Computers Inc.: Japan’s Challenge to IB4. Cambridge: Harvard UP, 1989. (HD 9696 .C63 J29 1989) Arrison, Thomas S., et. al...Strategv towards the East. London: International Institute for Strategic Studies, 1984. (U 162 .A23 no.192) Burke , Patrick, ed. Nuclear Weapons World

40 CFR 264.259 - Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27.

Code of Federal Regulations, 2014 CFR

2014-07-01

... wastes FO20, FO21, FO22, FO23, FO26, and FO27. 264.259 Section 264.259 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Waste Piles § 264.259 Special requirements for...

40 CFR 264.259 - Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27.

Code of Federal Regulations, 2012 CFR

2012-07-01

... wastes FO20, FO21, FO22, FO23, FO26, and FO27. 264.259 Section 264.259 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Waste Piles § 264.259 Special requirements for...

40 CFR 264.259 - Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27.

Code of Federal Regulations, 2013 CFR

2013-07-01

... wastes FO20, FO21, FO22, FO23, FO26, and FO27. 264.259 Section 264.259 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Waste Piles § 264.259 Special requirements for...

Earth Observations taken by the Expedition 23 Crew

NASA Image and Video Library

2010-04-10

ISS023-E-021307 (10 April 2010) --- Photographed by one of the Expedition 23 crew members onboard the International Space Station 220 miles above Earth, this is a broad area view of Sendai, Japan. The end of the shuttle vertical stabilizer points to Sendai.

22 CFR 226.23 - Cost sharing or matching.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADMINISTRATION OF ASSISTANCE AWARDS TO U.S. NON-GOVERNMENTAL ORGANIZATIONS Post-award Requirements Financial and Program Management § 226.23 Cost sharing or... volunteer services shall be consistent with those paid for similar work in the recipient's organizations. In...

Mouse-hamster chimeric prion protein (PrP) devoid of N-terminal residues 23-88 restores susceptibility to 22L prions, but not to RML prions in PrP-knockout mice.

PubMed

Uchiyama, Keiji; Miyata, Hironori; Yano, Masashi; Yamaguchi, Yoshitaka; Imamura, Morikazu; Muramatsu, Naomi; Das, Nandita Rani; Chida, Junji; Hara, Hideyuki; Sakaguchi, Suehiro

2014-01-01

Prion infection induces conformational conversion of the normal prion protein PrPC, into the pathogenic isoform PrPSc, in prion diseases. It has been shown that PrP-knockout (Prnp0/0) mice transgenically reconstituted with a mouse-hamster chimeric PrP lacking N-terminal residues 23-88, or Tg(MHM2Δ23-88)/Prnp 0/0 mice, neither developed the disease nor accumulated MHM2ScΔ23-88 in their brains after inoculation with RML prions. In contrast, RML-inoculated Tg(MHM2Δ23-88)/Prnp 0/+ mice developed the disease with abundant accumulation of MHM2ScΔ23-88 in their brains. These results indicate that MHM2Δ23-88 itself might either lose or greatly reduce the converting capacity to MHM2ScΔ23-88, and that the co-expressing wild-type PrPC can stimulate the conversion of MHM2Δ23-88 to MHM2ScΔ23-88 in trans. In the present study, we confirmed that Tg(MHM2Δ23-88)/Prnp 0/0 mice remained resistant to RML prions for up to 730 days after inoculation. However, we found that Tg(MHM2Δ23-88)/Prnp 0/0 mice were susceptible to 22L prions, developing the disease with prolonged incubation times and accumulating MHM2ScΔ23-88 in their brains. We also found accelerated conversion of MHM2Δ23-88 into MHM2ScΔ23-88 in the brains of RML- and 22L-inoculated Tg(MHM2Δ23-88)/Prnp 0/+ mice. However, wild-type PrPSc accumulated less in the brains of these inoculated Tg(MHM2Δ23-88)/Prnp 0/+ mice, compared with RML- and 22L-inoculated Prnp 0/+ mice. These results show that MHM2Δ23-88 itself can convert into MHM2ScΔ23-88 without the help of the trans-acting PrPC, and that, irrespective of prion strains inoculated, the co-expressing wild-type PrPC stimulates the conversion of MHM2Δ23-88 into MHM2ScΔ23-88, but to the contrary, the co-expressing MHM2Δ23-88 disturbs the conversion of wild-type PrPC into PrPSc.

Mouse-Hamster Chimeric Prion Protein (PrP) Devoid of N-Terminal Residues 23-88 Restores Susceptibility to 22L Prions, but Not to RML Prions in PrP-Knockout Mice

PubMed Central

Yano, Masashi; Yamaguchi, Yoshitaka; Imamura, Morikazu; Muramatsu, Naomi; Das, Nandita Rani; Chida, Junji; Hara, Hideyuki; Sakaguchi, Suehiro

2014-01-01

Prion infection induces conformational conversion of the normal prion protein PrPC, into the pathogenic isoform PrPSc, in prion diseases. It has been shown that PrP-knockout (Prnp0/0) mice transgenically reconstituted with a mouse-hamster chimeric PrP lacking N-terminal residues 23-88, or Tg(MHM2Δ23-88)/Prnp0/0 mice, neither developed the disease nor accumulated MHM2ScΔ23-88 in their brains after inoculation with RML prions. In contrast, RML-inoculated Tg(MHM2Δ23-88)/Prnp0/+ mice developed the disease with abundant accumulation of MHM2ScΔ23-88 in their brains. These results indicate that MHM2Δ23-88 itself might either lose or greatly reduce the converting capacity to MHM2ScΔ23-88, and that the co-expressing wild-type PrPC can stimulate the conversion of MHM2Δ23-88 to MHM2ScΔ23-88 in trans. In the present study, we confirmed that Tg(MHM2Δ23-88)/Prnp0/0 mice remained resistant to RML prions for up to 730 days after inoculation. However, we found that Tg(MHM2Δ23-88)/Prnp0/0 mice were susceptible to 22L prions, developing the disease with prolonged incubation times and accumulating MHM2ScΔ23-88 in their brains. We also found accelerated conversion of MHM2Δ23-88 into MHM2ScΔ23-88 in the brains of RML- and 22L-inoculated Tg(MHM2Δ23-88)/Prnp0/+ mice. However, wild-type PrPSc accumulated less in the brains of these inoculated Tg(MHM2Δ23-88)/Prnp0/+ mice, compared with RML- and 22L-inoculated Prnp0/+ mice. These results show that MHM2Δ23-88 itself can convert into MHM2ScΔ23-88 without the help of the trans-acting PrPC, and that, irrespective of prion strains inoculated, the co-expressing wild-type PrPC stimulates the conversion of MHM2Δ23-88 into MHM2ScΔ23-88, but to the contrary, the co-expressing MHM2Δ23-88 disturbs the conversion of wild-type PrPC into PrPSc. PMID:25330286

22 CFR 1600.149 - Program accessibility: Discrimination prohibited.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Program accessibility: Discrimination prohibited. 1600.149 Section 1600.149 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT... STATES FRIENDSHIP COMMISSION § 1600.149 Program accessibility: Discrimination prohibited. Except as...

40 CFR 264.231 - Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27. 264.231 Section 264.231 Protection of Environment... chemical characteristics of the wastes, including their potential to migrate through soil or to volatilize...

Noguchi and Williams in hatch area during Expedition 22

NASA Image and Video Library

2010-01-03

ISS022-E-018820 (3 Jan. 2010) --- NASA astronaut Jeffrey Williams (right), Expedition 22 commander; and Japan Aerospace Exploration Agency astronaut Soichi Noguchi, flight engineer, are pictured in a hatch on the International Space Station.

Noguchi at JPM window during Expedition 22

NASA Image and Video Library

2010-03-12

ISS022-E-091518 (12 March 2010) --- Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, Expedition 22 flight engineer, looks through a window in the Kibo laboratory of the International Space Station. The Japanese robotic Small Fine Arm (SFA), also known as ?Ko-bot?, is visible through the window.

40 CFR 264.283 - Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27. 264.283 Section 264.283 Protection of Environment... characteristics of the wastes, including their potential to migrate through soil or to volatilize or escape into...

40 CFR 264.317 - Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27. 264.317 Section 264.317 Protection of Environment..., including their potential to migrate through the soil or to volatilize or escape into the atmosphere; (2...

40 CFR 264.259 - Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Special requirements for hazardous wastes FO20, FO21, FO22, FO23, FO26, and FO27. 264.259 Section 264.259 Protection of Environment... through soil or to volatilize or escape into the atmosphere; (2) The attenuative properties of underlying...

Noguchi works on JEMRMS Limp Mode Transfer during Expedition 22

NASA Image and Video Library

2010-03-10

ISS022-E-089775 (10 March 2010) --- Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, Expedition 22 flight engineer, uses a computer in the Kibo laboratory of the International Space Station.

The importance of TH22 and TC22 cells in the pathogenesis of Helicobacter pylori-associated gastric diseases.

PubMed

Shamsdin, Seyedeh Azra; Alborzi, Abdolvahab; Rasouli, Manoochehr; Ghaderi, Abbas; Lankrani, Kamran B; Dehghani, Seyed Mohsen; Pouladfar, Gholam Reza

2017-06-01

An association exists between Helicobacter pylori (H. pylori), peptic ulcers, gastritis, and sometimes gastric carcinomas. Th22 cells have protective and inflammatory roles in defense against microbes. We investigated the frequencies of Th22, Tc22, Th22/17, and Tc22/17 cells in addition to the changes in levels of cytokines IL-22, IL-6, IL-23, TNF-α, IL-1β, and TGF-β in sera from patients with H. pylori-associated gastritis, and peptic ulcer, and in uninfected patients. A total of 76 patients with H. pylori-associated disorders formed the studied group. Frequencies of T-cell subsets were determined by flow cytometry. Levels of cytokines IL-22, IL-6, IL-23, TNF-α, IL-1β, and TGF-β in the sera and supernatants of patients were measured by ELISA and flow cytometry. The study participants included 32 males and 44 females with a mean age of 38.5±15.3 years. We divided the infected group into peptic ulcer and gastritis (mild, moderate, active chronic, and chronic). The frequencies of Th22, Tc22, and Tc22/17 increased significantly in the peptic ulcer, moderate, active chronic, and chronic gastritis groups compared to the uninfected group. Th22/17 only increased significantly in the chronic gastritis group. We observed significant increases in IL-22 in the moderate and active chronic gastritis, IL-23 in the active chronic and chronic gastritis, and TNF-α in the peptic ulcer and moderate gastritis groups. Following in vitro antigenic stimulation, we observed significantly higher levels of IL-1β, IL-23, and IL-6 in the active chronic gastritis group, as well as IL-6 and IL-1β in the chronic gastritis group compared to the uninfected group. Increased Th22, Tc22, and Tc22/17 cells and IL-22 levels appear to be influential in progression and severity of H. pylori infection. Th22/17 can be an interesting therapeutic target for chronic H. pylori infections where eradication is more difficult. © 2016 John Wiley & Sons Ltd.

De novo 12q22.q23.3 duplication associated with temporal lobe epilepsy.

PubMed

Vari, Maria Stella; Traverso, Monica; Bellini, Tommaso; Madia, Francesca; Pinto, Francesca; Minetti, Carlo; Striano, Pasquale; Zara, Federico

2017-08-01

Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy and may be associated with acquired central nervous system lesions or could be genetic. Various susceptibility genes and environmental factors are believed to be involved in the aetiology of TLE, which is considered to be a heterogeneous, polygenic, and complex disorder. Rare point mutations in LGI1, DEPDC5, and RELN as well as some copy number variations (CNVs) have been reported in families with TLE patients. We perform a genetic analysis by Array-CGH in a patient with dysmorphic features and temporal lobe epilepsy. We report a de novo duplication of the long arm of chromosome 12. We confirm that 12q22-q23.3 is a candidate locus for familial temporal lobe epilepsy with febrile seizures and highlight the role of chromosomal rearrangements in patients with epilepsy and intellectual disability. Copyright © 2017 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

The Evolving Relations of Japan and India

DTIC Science & Technology

2014-12-01

Does it Affect Us?,” Malaysia Chronicle, December 22, 2013, http://www.malaysia- chronicle.com/index.php?option=com_k2&view=item&id=201131:chinese... food industries” while Japan’s primary exports have been machinery components like boilers, marine products, jewels, and iron and steel.147 These areas...that time, Japan has been seeking alternative sources of rare earth metals, including India, Australia, Kazakhstan, and Malaysia with the intention of

Extreme EEJ and Topside Ionospheric Response to the 22-23 June 2015 Geomagnetic Storm

NASA Astrophysics Data System (ADS)

Astafyeva, E.; Zakharenkova, I.; Alken, P.; Coisson, P.

2016-12-01

In this work, we study the ionospheric and thermospheric response to the intense geomagnetic storm of 22-23 June 2015. With the minimum SYM-H excursion of -207 nT, this storm is so far the 2nd strongest geomagnetic storm in the current 24th solar cycle. The storm started with the arrival of a coronal mass ejection at 18:37UT on 22 June 2015. The interplanetary magnetic field (IMF) Bz component changed polarity several times during this storm. Consequently, the interplanetary electric field Ey component repeated this oscillatory behavior, and varied from -15 to +20 mV/m, which is comparable with storm-time levels. Data from multiple ground-based and space-borne instruments showed that both positive and negative ionospheric storms occurred during this storm at middle and low latitudes on both day and night sides. To study the drivers of the observed ionospheric effects, we further analyze variations of thermospheric parameters (neutral mass density and thermospheric O/N2 ratio), as well as the equatorial electrojet (EEJ) data as retrieved from magnetic measurements onboard Swarm satellites. One of the most interesting features of the June 2015 storm is observation of extremely high EEJ values (both eastward and westward), that correlate with variations of the IEF Ey. We find that the storm-time penetration electric fields were, most likely, the main driver of the observed ionospheric effects at the initial phase of the storm, and at the beginning of the main phase. At the end of the main phase, the thermospheric composition changes seemed to contribute as well.

22 CFR 135.23 - Period of availability of funds.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Administration § 135.23 Period of availability of funds. (a) General. Where a funding period is specified, a... carryover of unobligated balances is permitted, in which case the carryover balances may be charged for...

Noguchi in the JPM during Expedition 22

NASA Image and Video Library

2010-01-15

ISS022-E-026221 (15 Jan. 2010) --- Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, Expedition 22 flight engineer, services the Fluid Physics Experiment Facility/Marangoni Surface (FPEF MS) Core hardware in the Kibo laboratory of the International Space Station. The Marangoni convection experiment in the FPEF examines fluid tension flow in micro-G.

Noguchi in the JPM during Expedition 22

NASA Image and Video Library

2010-01-14

ISS022-E-025474 (14 Jan. 2010) --- Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, Expedition 22 flight engineer, services the Fluid Physics Experiment Facility/Marangoni Surface (FPEF MS) Core hardware in the Kibo laboratory of the International Space Station. The Marangoni convection experiment in the FPEF examines fluid tension flow in micro-G.

Noguchi uses laptop computer in the Node 2 during Expedition 22

NASA Image and Video Library

2010-01-19

ISS022-E-030641 (19 Jan. 2010) --- Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, Expedition 22 flight engineer, uses a computer in the Harmony node of the International Space Station.

During acute experimental infection with the reticulotropic Trypanosoma cruzi strain Tulahuen IL-22 is induced IL-23-dependently but is dispensable for protection.

PubMed

Erdmann, Hanna; Behrends, Jochen; Hölscher, Christoph

2016-09-21

Protective immunity against Trypanosoma cruzi, the causative agent of Chagas disease, depends on the activation of macrophages by IFN-γ and IL-17A. In contrast, IL-10 prevents immunopathology. IL-22 belongs to the IL-10 cytokine family and has pleiotropic effects during host defense and immunopathology, however its role in protection and pathology during T. cruzi infection has not been analyzed yet. Therefore, we examined the role of IL-22 in experimental Chagas disease using the reticulotropic Tulahuen strain of T. cruzi. During infection, IL-22 is secreted by CD4-positive cells in an IL-23-dependent fashion. Infected IL-22(-/-) mice exhibited an increased production of IFN-γ and TNF and displayed enhanced numbers of activated IFN-γ-producing T cells in their spleens. Additionally, the production of IL-10 was increased in IL-22(-/-) mice upon infection. Macrophage activation and by association the parasitemia was not affected in the absence of IL-22. Apart from a transient increase in the body weight loss, infected IL-22(-/-) mice did not show any signs for an altered immunopathology during the first fourteen days of infection. Taken together, although IL-22 is expressed, it seems to play a minor role in protection and pathology during the acute systemic infection with the reticulotropic Tulahuen strain of T. cruzi.

A Survey of Daily Trips of Persons Who Are Visually Impaired Living in Communities in Japan

ERIC Educational Resources Information Center

Shimizu, Michiko

2009-01-01

According to the Ministry of Health, Labor, and Welfare of Japan (2006), there are 379,000 persons with visual impairments (both those who are blind and those with low vision) in Japan. Of these persons, 30% travel almost daily, 30% travel two to three days per week, 22% travel two to three days per month, and 11% travel several days a year; in…

12 CFR 23.12 - Transition rule.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Transition rule. 23.12 Section 23.12 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY LEASING CEBA Leases § 23.12 Transition rule. (a) General rule. A CEBA Lease entered into prior to July 22, 1991, may continue to be...

Current status of portal vein thrombosis in Japan: Results of a questionnaire survey by the Japan Society for Portal Hypertension.

PubMed

Kojima, Seiichiro; Watanabe, Norihito; Koizumi, Jun; Kokubu, Shigehiro; Murashima, Naoya; Matsutani, Shoichi; Obara, Katsutoshi

2018-03-01

To investigate the current status of portal vein thrombosis (PVT) in Japan, the Clinical Research Committee of the Japan Society of Portal Hypertension undertook a questionnaire survey. A questionnaire survey of 539 cases of PVT over the previous 10 years was carried out at institutions affiliated with the Board of Trustees of the Japan Society of Portal Hypertension. The most frequent underlying etiology of PVT was liver cirrhosis in 75.3% of patients. Other causes included inflammatory diseases of the hepatobiliary system and the pancreas, malignant tumors, and hematologic diseases. The most frequent site was the main trunk of the portal vein (MPV) in 70.5%, and complete obstruction of the MPV was present in 11.5%. Among the medications for PVT, danaparoid was given to 45.8%, warfarin to 26.2%, heparin to 17.3%, and anti-thrombin III to 16.9%. Observation of the course was practiced in 22.4%. Factors contributing to therapeutic efficacy were implementation of various medications, thrombi localized to either the right or left portal vein only, non-complete obstruction of the MPV and Child-Pugh class A liver function. A survival analysis showed that the prognosis was favorable with PVT disappearance regardless of treatment. The questionnaire survey showed the current status of PVT in Japan. Any appropriate medication should be given to a patient with PVT when PVT is recognized. It is necessary to compile a large amount of information and reach a consensus on safe and highly effective management of PVT. © 2017 The Japan Society of Hepatology.

HATS-22b, HATS-23b and HATS-24b: three new transiting super-Jupiters from the HATSouth project

NASA Astrophysics Data System (ADS)

Bento, J.; Schmidt, B.; Hartman, J. D.; Bakos, G. Á.; Ciceri, S.; Brahm, R.; Bayliss, D.; Espinoza, N.; Zhou, G.; Rabus, M.; Bhatti, W.; Penev, K.; Csubry, Z.; Jordán, A.; Mancini, L.; Henning, T.; de Val-Borro, M.; Tinney, C. G.; Wright, D. J.; Durkan, S.; Suc, V.; Noyes, R.; Lázár, J.; Papp, I.; Sári, P.

2017-06-01

We report the discovery of three moderately high-mass transiting hot Jupiters from the HATSouth survey: HATS-22b, HATS-23b and HATS-24b. These planets add to the number of known planets in the ˜2MJ regime. HATS-22b is a 2.74 ± 0.11 MJ mass and 0.953_{-0.029}^{+0.048} R_J radius planet orbiting a V = 13.455 ± 0.040 sub-solar mass (M* = 0.759 ± 0.019 M⊙; R* = 0.759 ± 0.019 R⊙) K-dwarf host star on an eccentric (e = 0.079 ± 0.026) orbit. This planet's high planet-to-stellar mass ratio is further evidence that migration mechanisms for hot Jupiters may rely on exciting orbital eccentricities that bring the planets closer to their parent stars followed by tidal circularization. HATS-23b is a 1.478 ± 0.080 MJ mass and 1.69 ± 0.24 RJ radius planet on a grazing orbit around a V = 13.901 ± 0.010 G-dwarf with properties very similar to those of the Sun (M* = 1.115 ± 0.054; R* = 1.145 ± 0.070). HATS-24b orbits a moderately bright V = 12.830 ± 0.010 F-dwarf star (M* = 1.218 ± 0.036 M⊙; R_\\star = 1.194_{-0.041}^{+0.066} R_{⊙}). This planet has a mass of 2.39_{-0.12}^{+0.21} M_J and an inflated radius of 1.516_{-0.065}^{+0.085} R_J.

Current status of pregnancy-related maternal mortality in Japan: a report from the Maternal Death Exploratory Committee in Japan.

PubMed

Hasegawa, Junichi; Sekizawa, Akihiko; Tanaka, Hiroaki; Katsuragi, Shinji; Osato, Kazuhiro; Murakoshi, Takeshi; Nakata, Masahiko; Nakamura, Masamitsu; Yoshimatsu, Jun; Sadahiro, Tomohito; Kanayama, Naohiro; Ishiwata, Isamu; Kinoshita, Katsuyuki; Ikeda, Tomoaki

2016-03-21

To clarify the problems related to maternal deaths in Japan, including the diseases themselves, causes, treatments and the hospital or regional systems. Descriptive study. Maternal death registration system established by the Japan Association of Obstetricians and Gynecologists (JAOG). Women who died during pregnancy or within a year after delivery, from 2010 to 2014, throughout Japan (N=213). The preventability and problems in each maternal death. Maternal deaths were frequently caused by obstetric haemorrhage (23%), brain disease (16%), amniotic fluid embolism (12%), cardiovascular disease (8%) and pulmonary disease (8%). The Committee considered that it was impossible to prevent death in 51% of the cases, whereas they considered prevention in 26%, 15% and 7% of the cases to be slightly, moderately and highly possible, respectively. It was difficult to prevent maternal deaths due to amniotic fluid embolism and brain disease. In contrast, half of the deaths due to obstetric haemorrhage were considered preventable, because the peak duration between the initial symptoms and initial cardiopulmonary arrest was 1-3 h. A range of measures, including individual education and the construction of good relationships among regional hospitals, should be established in the near future, to improve primary care for patients with maternal haemorrhage and to save the lives of mothers in Japan. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Childhood-onset schizophrenia case with 2.2 Mb deletion at chromosome 3p12.2–p12.1 and two large chromosomal abnormalities at 16q22.3–q24.3 and Xq23–q28

PubMed Central

Rudd, Danielle; Axelsen, Michael; Epping, Eric A; Andreasen, Nancy; Wassink, Thomas

2015-01-01

Key Clinical Message Childhood-onset schizophrenia is rare, comprising 1% of known schizophrenia cases. Here, we report a patient with childhood-onset schizophrenia who has three large chromosomal abnormalities: an inherited 2.2 Mb deletion of chromosome 3p12.2–p12.1, a de novo 16.7 Mb duplication of 16q22.3–24.3, and a de novo 43 Mb deletion of Xq23–q28. PMID:25914809

Boston Harbor, Massachusetts Feasibility Report for Debris Removal. Volume 2. Part A-Debris Inventory. Summary Sheets. Part B - Land Enhancement. Summary Sheets. Revision.

DTIC Science & Technology

1980-05-01

Holand -American line to Rotterdam, the Havana line to Havana, the American-Indian line from Calcutta, the China-Japan line from Yokohama and the Clay... f1 ) >i ’(D C 4- -𔃾 C - C) cc- 0i.L 0f 0’~ 44 U))v) 0 ~~5,~0 P) j ~ UCC 4-) .) - 0 ’ ~ 0 0~ 4-’ C)’C 0 00D fU LO. 00 C -H 𔃺*.4 Q ) U)j 0E . 00.3q C

International Conference on Crystal Growth (10th) (ICCG-10) Held in San Diego, California on August 16 - 21, 1992

DTIC Science & Technology

1992-08-21

Synthetic Crystals. China82 The Growth of LaMgA],,O,,:Nd Large Crystals with High Quality B16 G, Wu. X Ma.* J. Xu. X Zhang and Y. Shen Crystal Growth and...Stolchlometry Problems of ZnSe for High Power Laser Y. ShIralshl Optical Components Kimura Metamelt Project. Japan E~ Kjause.* A. Moseal and H. Harmnn...Maki- Shanghai Institute of Ceramics. China Yokohama City University. Japa 023 CS Growth of High -CluaI~ty TI:A1202 Crystals for Solid-State Lase In

Cooling in the Post-Sunrise Equatorial Topside Ionosphere During the 22-23 June 2015 Superstorm

NASA Astrophysics Data System (ADS)

Stoneback, R.; Hairston, M. R.; Coley, W. R.; Heelis, R. A.

2015-12-01

During the recovery phase of the 22-23 June 2015 superstorm multiple DMSP spacecraft observed two separate and short-lived (~ 30 minutes) events of localized cooling in the topside equatorial ionosphere (~840 km) in the post-sunrise region (between 6:15 and 7:30 local time). The ion temperatures dropped from the nominal 2000-3000° observed in these regions to 1000 to 1500°. This cooling effect was not observed on the corresponding duskside equatorial crossings of the DMSP spacecraft during this storm. Further, these cooling events do not normally occur during major storms; no such phenomenon was observed by DMSP during the March 2015 superstorm. Flow data from DMSP and the CINDI instruments on the C/NOFS spacecraft indicate these cooling events are associated with short-lived vertical flows bringing up cooler plasma from lower altitudes. The two cooling events correspond to large northward turnings of the IMF during the storm and these are being explored as a possible trigger mechanism.

An outbreak of food-borne gastroenteritis due to sapovirus among junior high school students.

PubMed

Usuku, Shuzo; Kumazaki, Makoto; Kitamura, Katsuhiko; Tochikubo, Osamu; Noguchi, Yuzo

2008-11-01

The human sapovirus (SaV) causes acute gastroenteritis mainly in infants and young children. A food-borne outbreak of gastroenteritis associated with SaV occurred among junior high school students in Yokohama, Japan, during and after a study trip. The nucleotide sequences of the partial capsid gene derived from the students exhibited 98% homology to a SaV genogroup IV strain, Hu/Angelholm/SW278/2004/SE, which was isolated from an adult with gastroenteritis in Solna, Sweden. An identical nucleotide sequence was detected from a food handler at the hotel restaurant, suggesting that the causative agent of the outbreak was transmitted from the food handler. This is the first description of a food-borne outbreak associated with the SaV genogroup IV strain in Japan.

22 CFR 42.23 - Certain former U.S. citizens.

Code of Federal Regulations, 2010 CFR

2010-04-01

....23 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Immigrants Not Subject to Numerical Limitations of INA 201 and 202... status, shall be classifiable as a special immigrant under INA 101(a)(27)(B) if the consular officer is...

Influence of hearing of 22 G Whitacre and 22 G Quincke needles.

PubMed

Sundberg, A; Wang, L P; Fog, J

1992-11-01

Audiograms were performed pre-operatively and 2 days postoperatively in 48 patients given spinal anaesthesia for transurethral resection of the prostate. Hearing levels were examined at 1000 Hz and below. Either 22 G standard design (Quincke) needles (n = 25) or 22 G pencil-point design (Whitacre) needles (n = 23) were used. Hearing loss of 10 dB or more at two or more frequencies were observed in six of 25 patients in the Quincke group and in two of 23 patients in the Whitacre group. The mean hearing level was more reduced in the Quincke group. The shape of the tip of the spinal needle seems to be of some importance to the effects on hearing level that may occur after spinal anaesthesia.

22 CFR 1600.151 - Program accessibility: New construction and alterations.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Program accessibility: New construction and alterations. 1600.151 Section 1600.151 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT... STATES FRIENDSHIP COMMISSION § 1600.151 Program accessibility: New construction and alterations. Each...

22 CFR 1600.151 - Program accessibility: New construction and alterations.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Program accessibility: New construction and alterations. 1600.151 Section 1600.151 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT... STATES FRIENDSHIP COMMISSION § 1600.151 Program accessibility: New construction and alterations. Each...

22 CFR 1600.151 - Program accessibility: New construction and alterations.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Program accessibility: New construction and alterations. 1600.151 Section 1600.151 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT... STATES FRIENDSHIP COMMISSION § 1600.151 Program accessibility: New construction and alterations. Each...

22 CFR 1600.151 - Program accessibility: New construction and alterations.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Program accessibility: New construction and alterations. 1600.151 Section 1600.151 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT... STATES FRIENDSHIP COMMISSION § 1600.151 Program accessibility: New construction and alterations. Each...

Japan.

ERIC Educational Resources Information Center

Geiger, Rita; And Others

The document offers practical and motivating techniques for studying Japan. Dedicated to promoting global awareness, separate sections discuss Japan's geography, history, culture, education, government, economics, energy, transportation, and communication. Each section presents a topical overview; suggested classroom activities; and easily…

β decay of proton-rich nucleus Al23 and astrophysical consequences

NASA Astrophysics Data System (ADS)

Iacob, V. E.; Zhai, Y.; Al-Abdullah, T.; Fu, C.; Hardy, J. C.; Nica, N.; Park, H. I.; Tabacaru, G.; Trache, L.; Tribble, R. E.

2006-10-01

We present the first study of the β decay of Al23 undertaken with pure samples. The study was motivated by nuclear astrophysics questions. Pure samples of Al23 were obtained from the momentum achromat recoil separator (MARS) of Texas A&M University, collected on a fast tape-transport system, and moved to a shielded location where β and β-γ coincidence measurements were made. We deduced β branching ratios and log ft values for transitions to states in Mg23, and from them determined unambiguously the spin and parity of the Al23 ground state to be Jπ=5/2+. We discuss how this excludes the large increases in the radiative proton capture cross section for the reaction Mg22(p,γ)Al23 at astrophysical energies, which were implied by claims that the spin and parity is Jπ=1/2+. The log ft for the Fermi transition to its isobaric analog state (IAS) in Mg23 is also determined for the first time. This IAS and a state 16 keV below it are observed, well separated in the same experiment for the first time. We can now solve a number of inconsistencies in the literature, exclude strong isospin mixing claimed before, and obtain a new determination of the resonance strength. Both states are resonances in the Na22(p,γ)Mg23 reaction at energies important in novae. The reactions Mg22(p,γ)Al23 and Na22(p,γ)Mg23 have both been suggested as possible candidates for diverting some of the flux in oxygen-neon novae explosions from the A=22 into the A=23 mass chain.

Introductory Overview of Stone Heritages in Japan

NASA Astrophysics Data System (ADS)

Kato, Hirokazu; Oikawa, Teruki; Fujita, Masayo; Yokoyama, Shunji

2013-04-01

As one contribution to 'Global Heritage Stone Resources' (GHSR), some stone heritages in Japan, which are nominated in the interim list, are briefly introduced. The geology of Japanese Islands where are the one of the most active areas in the history of the Earth, is very complicated. Therefore Japanese Islands consist of various kinds of minerals and rocks. Some of them were used to make stone implements and accessories. Japanese people also used to the best possible advantage to built tombstone, gate, pavement ,and the basement and wall of the large building such as temples, shrines, castles and modern buildings. 1. Stone Heritages of Pre-historical age: In the late Pleistocene and the early Holocene, ancient Japanese used obsidian cooled rapidly from rhyolitic magma.to make small implements and accessories. For example, Shirataki, Hokkaido (north island) is the largest place producing obsidian in Japan where Paleolithic people made arrowhead, knives and so on. Another example, Jade yielded in Itoigawa City, Japan Sea coast of central Japan, was made in the metamorphic rock about five hundred million years ago. Itoigawa area is only one place where jade is abundantly produced in Japan. Ancient people had been already collected and processed to ornaments although it is very hard and traded in wide area more than several thousand years ago. 2. Stone Heritages of Historical age: 2.1 Archaeological remains: In the Kofun (old mound) period (250 to 538 AD), stone burial chambers were used for old mounds to preserve against the putrefaction and to protect from the theft. For example, Ishibutai Kofun ("ishi" means "stone" and "butai" means "stage") in Nara old capital city, southwest Japan, is the largest known megalithic structure made of granite in Japan. 2.2 Stone walls of some typical castles Stones used is because of not only the rich reserves of rocks but also restriction of transportation. Osaka (second biggest city) castle, are composed of Cretaceous granite

Clinical statistics of gynecologic cancers in Japan.

PubMed

Yamagami, Wataru; Nagase, Satoru; Takahashi, Fumiaki; Ino, Kazuhiko; Hachisuga, Toru; Aoki, Daisuke; Katabuchi, Hidetaka

2017-03-01

Cervical, endometrial, and ovarian cancers, have both high morbidity and mortality among the gynecologic malignant tumors in Japan. The present study was conducted using both the population-based cancer registry and the gynecologic cancer registry to elucidate the characteristics of gynecologic malignant tumors in Japan. Based on nationwide estimates from the population-based cancer registry in Japan, the morbidities and mortality of cervical, endometrial, and ovarian cancers were obtained and used for analysis. Clinicopathologic factors for cervical cancer, endometrial cancer, ovarian cancer, including age, clinical stage, postsurgical stage, histological type, therapeutic strategy, and prognosis were retrieved from the gynecologic cancer registry published by the Japan Society of Obstetrics and Gynecology and used for analysis. The morbidities of cervical, endometrial, and ovarian cancers were 10,908, 13,606, and 9,384 women in 2012, respectively. The prevalence of endometrial cancer has significantly and consistently been increasing and represents the most common gynecologic malignant tumor in Japan. The mortalities of cervical, endometrial, and ovarian cancers were 2.1, 1.3, and 3.2 per 100,000 in 2012, respectively. In 2014, 52.2% of cervical cancer patients were classified as stage I, 22.5% as stage II, 10.2% as stage III, and 11.2% as stage IV. In addition, 71.9% of endometrial cancer patients were classified as stage I, 6.0% as stage II, 13.3% as stage III, and 7.5% as stage IV. Finally, 43.2% of ovarian cancer patients were classified as stage I, 9.1% as stage II, 27.6% as stage III, and 7.2% as stage IV. Twelve-point six percent of ovarian cancer patients received neoadjuvant chemotherapy. Copyright © 2017. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology.

Liver transplantation in Japan.

PubMed

Soyama, Akihiko; Eguchi, Susumu; Egawa, Hiroto

2016-10-01

As of December 31, 2014, 7937 liver transplants (7673 living donor transplants and 264 deceased donor liver transplantations [DDLTs; 261 from heart-beating donors and 3 from non-heart-beating donors]) have been performed in 67 institutions in Japan. The revised Organ Transplant Law in Japan came into effect in July 2010, which allows organ procurement from brain-dead individuals, including children, with family consent if the patient had not previously refused organ donation. However, the number of deceased donor organ donations has not increased as anticipated. The rate of deceased organ donations per million population (pmp) has remained at less than 1. To maximize the viability of the limited numbers of donated organs, a system has been adopted that includes the partnership of well-trained transplant consultant doctors and local doctors. For compensating for the decreased opportunity of on-site training, an educational system regarding quality organ procurement for transplant surgeons has also been established. Furthermore, experts in the field of liver transplantation are currently discussing adoption of the Model for End-Stage Liver Disease score for allocation, promoting split-liver transplantation, arranging in-house coordinators, and improving the frequency of proposing the option to donate organs to the families. To overcome the shortage of donors during efforts to promote organ donation, living donor liver transplantation (LDLT) has been developed in Japan. Continuous efforts to increase DDLT in addition to the successful experience of LDLT will increase the benefits of liver transplantation for more patients. Liver Transplantation 22 1401-1407 2016 AASLD. © 2016 by the American Association for the Study of Liver Diseases.

A short history of tsunami research and countermeasures in Japan

PubMed Central

Shuto, Nobuo; Fujima, Koji

2009-01-01

The tsunami science and engineering began in Japan, the country the most frequently hit by local and distant tsunamis. The gate to the tsunami science was opened in 1896 by a giant local tsunami of the highest run-up height of 38 m that claimed 22,000 lives. The crucial key was a tide record to conclude that this tsunami was generated by a “tsunami earthquake”. In 1933, the same area was hit again by another giant tsunami. A total system of tsunami disaster mitigation including 10 “hard” and “soft” countermeasures was proposed. Relocation of dwelling houses to high ground was the major countermeasures. The tsunami forecasting began in 1941. In 1960, the Chilean Tsunami damaged the whole Japanese Pacific coast. The height of this tsunami was 5–6 m at most. The countermeasures were the construction of structures including the tsunami breakwater which was the first one in the world. Since the late 1970s, tsunami numerical simulation was developed in Japan and refined to become the UNESCO standard scheme that was transformed to 22 different countries. In 1983, photos and videos of a tsunami in the Japan Sea revealed many faces of tsunami such as soliton fission and edge bores. The 1993 tsunami devastated a town protected by seawalls 4.5 m high. This experience introduced again the idea of comprehensive countermeasures, consisted of defense structure, tsunami-resistant town development and evacuation based on warning. PMID:19838008

A short history of tsunami research and countermeasures in Japan.

PubMed

Shuto, Nobuo; Fujima, Koji

2009-01-01

The tsunami science and engineering began in Japan, the country the most frequently hit by local and distant tsunamis. The gate to the tsunami science was opened in 1896 by a giant local tsunami of the highest run-up height of 38 m that claimed 22,000 lives. The crucial key was a tide record to conclude that this tsunami was generated by a "tsunami earthquake". In 1933, the same area was hit again by another giant tsunami. A total system of tsunami disaster mitigation including 10 "hard" and "soft" countermeasures was proposed. Relocation of dwelling houses to high ground was the major countermeasures. The tsunami forecasting began in 1941. In 1960, the Chilean Tsunami damaged the whole Japanese Pacific coast. The height of this tsunami was 5-6 m at most. The countermeasures were the construction of structures including the tsunami breakwater which was the first one in the world. Since the late 1970s, tsunami numerical simulation was developed in Japan and refined to become the UNESCO standard scheme that was transformed to 22 different countries. In 1983, photos and videos of a tsunami in the Japan Sea revealed many faces of tsunami such as soliton fission and edge bores. The 1993 tsunami devastated a town protected by seawalls 4.5 m high. This experience introduced again the idea of comprehensive countermeasures, consisted of defense structure, tsunami-resistant town development and evacuation based on warning.

48 CFR 23.505 - Contract clause.

Code of Federal Regulations, 2010 CFR

2010-10-01

... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 23.505 Contract clause. Except as provided in 23.501, insert the clause at 52.223-6, Drug-Free Workplace, in solicitations and contracts. [68 FR 28082, May 22...

48 CFR 23.505 - Contract clause.

Code of Federal Regulations, 2014 CFR

2014-10-01

... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 23.505 Contract clause. Except as provided in 23.501, insert the clause at 52.223-6, Drug-Free Workplace, in solicitations and contracts. [68 FR 28082, May 22...

48 CFR 23.505 - Contract clause.

Code of Federal Regulations, 2012 CFR

2012-10-01

... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 23.505 Contract clause. Except as provided in 23.501, insert the clause at 52.223-6, Drug-Free Workplace, in solicitations and contracts. [68 FR 28082, May 22...

48 CFR 23.505 - Contract clause.

Code of Federal Regulations, 2013 CFR

2013-10-01

... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 23.505 Contract clause. Except as provided in 23.501, insert the clause at 52.223-6, Drug-Free Workplace, in solicitations and contracts. [68 FR 28082, May 22...

48 CFR 23.505 - Contract clause.

Code of Federal Regulations, 2011 CFR

2011-10-01

... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 23.505 Contract clause. Except as provided in 23.501, insert the clause at 52.223-6, Drug-Free Workplace, in solicitations and contracts. [68 FR 28082, May 22...

A multicentre prospective study of Guillain-Barré syndrome in Japan: a focus on the incidence of subtypes.

PubMed

Mitsui, Yoshiyuki; Kusunoki, Susumu; Arimura, Kimiyoshi; Kaji, Ryuji; Kanda, Takashi; Kuwabara, Satoshi; Sonoo, Masahiro; Takada, Kazuo

2015-01-01

Guillain-Barré Syndrome (GBS) is classified into the two major subtypes; acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). Previous studies have suggested that AIDP is predominant and AMAN is rare in Western countries, whereas AMAN is not always uncommon in East Asia. We aimed to clarify the incidence of the subtypes of GBS in Japan. We performed a prospective multicentre survey over 3 years (2007-2010). Clinical and electrophysiological findings were collected from 184 patients with GBS in 23 tertiary neurology institutes. Anti-ganglioside antibodies were measured by ELISA. We also surveyed the incidence of Fisher syndrome (FS). By electrodiagnostic criteria of Ho et al, patients were classified as having AIDP (40%), or AMAN (22%), or unclassified (38%). Anti-GM1 IgG antibodies were found for 47% of AMAN patients, and 18% of AIDP patients (p<0.001). There were no specific regional trends of the electrodiagnosis and anti-GM1 positivity. During the same study period, 79 patients with FS were identified; the percentage of FS cases out of all cases (FS/(GBS+FS)) was 26%. The frequency of GBS patients with the electrodiagnosis of AMAN by single nerve conduction studies is approximately 20% in Japan, and the AMAN pattern is closely associated with anti-GM1 antibodies. The incidence of FS appears to be much higher in Japan than in Western countries. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

MSG in the Columbus Laboratory during Expedition 22

NASA Image and Video Library

2010-01-28

ISS022-E-041766 (28 Jan. 2010) --- Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, Expedition 22 flight engineer, works with the European Space Agency (ESA) science payload Selectable Optical Diagnostics Instrument / Influence of Vibration on Diffusion in Liquids (SODI/IVIDIL) hardware in the Microgravity Science Glovebox (MSG) facility located in the Columbus laboratory of the International Space Station.

MSG in the Columbus Laboratory during Expedition 22

NASA Image and Video Library

2010-01-28

ISS022-E-041767 (28 Jan. 2010) --- Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, Expedition 22 flight engineer, works with the European Space Agency (ESA) science payload Selectable Optical Diagnostics Instrument / Influence of Vibration on Diffusion in Liquids (SODI/IVIDIL) hardware in the Microgravity Science Glovebox (MSG) facility located in the Columbus laboratory of the International Space Station.

MSG in the Columbus Laboratory during Expedition 22

NASA Image and Video Library

2010-01-28

ISS022-E-041769 (28 Jan. 2010) --- Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, Expedition 22 flight engineer, works with the European Space Agency (ESA) science payload Selectable Optical Diagnostics Instrument / Influence of Vibration on Diffusion in Liquids (SODI/IVIDIL) hardware in the Microgravity Science Glovebox (MSG) facility located in the Columbus laboratory of the International Space Station.

Contrasts in the Behavior of Tremor Episodes in Cascadia and Japan

NASA Astrophysics Data System (ADS)

Armbruster, J. G.

2016-12-01

Tectonic tremor is observed in episodes with varying duration, intensity and spatial extent. In Cascadia the POLARIS broadband deployment, 2003-2006, provides good coverage of the southern Vancouver Island region with strong, widely distributed tremor sources extending 100 km along the plate interface. There the tremor can be classified into major episodes occurring at 14 month intervals with duration 20-30 days and minor episodes lasting hours to 10 days. Within that shorter duration minor episodes can produce strong signals. There is a clear pattern that minor episodes are located at the deeper part of the plate interface, 43-50 km deep. Major episodes are mostly generated from the shallower, 33-43 km deep, portion of the plate interface with some activation of the deeper sources. This suggests a simple mechanism of stress loading from below, transmitted upward by the tremor/slow-slip episodes. We compare this to the northern Kii Peninsula region of southwest Japan which has strong tremor sources extending 100 km along strike covered by HINET stations and find differences. The spectrum of episode durations in Japan, from less than an hour to 13 days, are not easily classified into major and minor. The range in depth observed in Japan is narrower than in Cascadia, 34-45 km for 98% of the clustered events. Here we divide the episodes into three groups based on their spatial extent. Large episodes occur at intervals of 6 months and occupy the southern 2/3, northern 2/3 or whole of the 100 km long zone. The small episodes are predominately seen from paired sources at the top and bottom of the active zone located where large episodes terminate. Intermediate episodes are the fewest in number and extend from the bottom to the top, often encompassing pairs of small sources. The observations in Japan will require a more complex model of stress loading. These results were achieved with the cross-station location method. The envelope location method might not have

40 CFR 144.23 - Class IV wells.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Class IV wells. 144.23 Section 144.23... INJECTION CONTROL PROGRAM Authorization of Underground Injection by Rule § 144.23 Class IV wells. (a) Injection into existing Class IV wells is authorized for up to six months after approval or promulgation of...

Japan’s Strategic Future: Coalition Operations

DTIC Science & Technology

2004-03-01

34thank-you" to Michael T. McMaster, CDR, USN (Ret.) for his tireless dedication in reading numerous drafts of this thesis in order to create...Institute, Professor Schoppa spoke on this topic at FPRI’s History Institute on Teaching About Japan, October 19-22, 2003. 15 the alliance with the United...all the amenities of home including a gym, internet café, library, and of course a karaoke bar. All JSDF personnel will be confined to the camp

Direct measurement of nuclear cross sections of astrophysical relevance at LUNA: The 22Ne(p, γ) 23Na reaction

NASA Astrophysics Data System (ADS)

Ferraro, F.; LUNA Collaboration

2017-01-01

Most of the elements constituting the universe were produced in stars through a series of nuclear reactions. LUNA performs direct measurements of nuclear cross sections relevant to astrophysics, taking advantage of the low background at LNGS. The ^{22}Ne(p,γ)^{23}Na reaction rate, which belongs to the NeNa cycle of hydrogen burning, has been recently studied. Its rate is still very uncertain because of a lot of resonances lying inside the Gamow window. LUNA discovered three new resonances using two high-purity germanium detectors and considerably improved the existing upper limits on the lower energy resonances using a high-efficiency optically-segmented BGO crystal.

Precise hypocenter locations of midcrustal low-frequency earthquakes beneath Mt. Fuji, Japan

USGS Publications Warehouse

Nakamichi, H.; Ukawa, M.; Sakai, S.

2004-01-01

Midcrustal low-frequency earthquakes (MLFs) have been observed at seismic stations around Mt. Fuji, Japan. In September - December 2000 and April - May 2001, abnormally high numbers of MLFs occurred. We located hypocenters for the 80 MLFs during 1998-2003 by using the hypoDD earthquake location program (Waldhauser and Ellsworth, 2000). The MLF hypocenters define an ellipsoidal volume some 5 km in diameter ranging from 11 to 16 km in focal depth. This volume is centered 3 km northeast of the summit and its long axis is directed NW-SE. The direction of the axis coincides with the major axis of tectonic compression around Mt. Fuji. The center of the MLF epicenters gradually migrated upward and 2-3 km from southeast to northwest during 1998-2001. We interpret that the hypocentral migration of MLFs reflects magma movement associated with a NW-SE oriented dike beneath Mt. Fuji. Copyright ?? The Society of Geomagnetism and Earth, Planetary and Space Sciences (SGEPSS); The Seismological Society of Japan; The Volcanological Society of Japan; The Geodetic Society of Japan; The Japanese Society for Planetary Sciences.

Analysis of the role of Arabidopsis class I TCP genes AtTCP7, AtTCP8, AtTCP22, and AtTCP23 in leaf development

PubMed Central

Aguilar-Martínez, José A.; Sinha, Neelima

2013-01-01

TCP family of plant-specific transcription factors regulates plant form through control of cell proliferation and differentiation. This gene family is comprised of two groups, class I and class II. While the role of class II TCP genes in plant development is well known, data about the function of some class I TCP genes is lacking. We studied a group of phylogenetically related class I TCP genes: AtTCP7, AtTCP8, AtTCP22, and AtTCP23. The similar expression pattern in young growing leaves found for this group suggests similarity in gene function. Gene redundancy is characteristic in this group, as also seen in the class II TCP genes. We generated a pentuple mutant tcp8 tcp15 tcp21 tcp22 tcp23 and show that loss of function of these genes results in changes in leaf developmental traits. We also determined that these factors are able to mutually interact in a yeast two-hybrid assay and regulate the expression of KNOX1 genes. To circumvent the issue of genetic redundancy, dominant negative forms with SRDX repressor domain were used. Analysis of transgenic plants expressing AtTCP7-SRDX and AtTCP23-SRDX indicate a role of these factors in the control of cell proliferation. PMID:24137171

Analysis of the role of Arabidopsis class I TCP genes AtTCP7, AtTCP8, AtTCP22, and AtTCP23 in leaf development.

PubMed

Aguilar-Martínez, José A; Sinha, Neelima

2013-01-01

TCP family of plant-specific transcription factors regulates plant form through control of cell proliferation and differentiation. This gene family is comprised of two groups, class I and class II. While the role of class II TCP genes in plant development is well known, data about the function of some class I TCP genes is lacking. We studied a group of phylogenetically related class I TCP genes: AtTCP7, AtTCP8, AtTCP22, and AtTCP23. The similar expression pattern in young growing leaves found for this group suggests similarity in gene function. Gene redundancy is characteristic in this group, as also seen in the class II TCP genes. We generated a pentuple mutant tcp8 tcp15 tcp21 tcp22 tcp23 and show that loss of function of these genes results in changes in leaf developmental traits. We also determined that these factors are able to mutually interact in a yeast two-hybrid assay and regulate the expression of KNOX1 genes. To circumvent the issue of genetic redundancy, dominant negative forms with SRDX repressor domain were used. Analysis of transgenic plants expressing AtTCP7-SRDX and AtTCP23-SRDX indicate a role of these factors in the control of cell proliferation.

Epidemiological study of erythromycin-resistant Streptococcus pyogenes from Korea and Japan by emm genotyping and multilocus sequence typing.

PubMed

Takahashi, Takashi; Arai, Kazuaki; Lee, Dong Hyun; Koh, Eun Ha; Yoshida, Haruno; Yano, Hisakazu; Kaku, Mitsuo; Kim, Sunjoo

2016-01-01

We determined the epidemiological characteristics of erythromycin (EM)-resistant Streptococcus pyogenes (group A streptococci, GAS) strains isolated from Korea and Japan, using emm genotyping and multilocus sequence typing (MLST). Clinical isolates of GAS had been collected from 1992 to 2012 in Korea and from 2004 to 2009 in Japan. EM resistance was determined by the microdilution method, and resistance genotypes were assessed by PCR. The emm genotyping and MLST were performed by DNA sequencing. The emm genotypes and sequence types (STs) were concordant in 143 (85.1%) of 168 EM-resistant GAS strains from Korea. ST36/emm12 (35.1%), ST52/emm28 (22.6%), and ST49/emm75 (16.1%) were the most common types. Most of the ST36 (93.9%) and ST52 (95.8%) strains harbored erm(B), whereas strains ST49, ST42, and ST15 contained mef(A). The concordance between emm genotypes and STs was 41 (93.2%) among 44 EM-resistant GAS strains from Japan. ST36/emm12 (34.1%), ST49/emm75 (18.2%), and ST28/emm1 (15.9%) were the major types. ST36 isolates harbored either erm(B) (56.3%) or mef(A) (37.5%), whereas isolates ST28, ST49, and ST38 carried only mef(A). The proportion of erm(B) and mef(A) was 66.1% and 33.3% in Korea and 22.7% and 68.2% in Japan, respectively. The common STs in Korea and Japan were ST36 and ST49, whereas ST52 was present only in Korea and ST28 only in Japan. Genotype erm(B) was predominant in Korea, whereas mef(A) was frequent in Japan. There were differences between Korea and Japan regarding the frequencies of emm genotypes, STs, and EM resistance genes among the EM-resistant GAS.

40 CFR 304.23 - Disclosure and challenge procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... 304.23 Section 304.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND... RECOVERY CLAIMS Jurisdiction of Arbitrator, Referral of Claims, and Appointment of Arbitrator § 304.23 Disclosure and challenge procedures. (a) A person appointed as an Arbitrator under § 304.22 of this part...

PTC Mid Year Seminar. Collection of Presentations (Yokohama, Japan, June 3-4, 1997).

ERIC Educational Resources Information Center

Ando, Takatoshi

This proceedings volume from the Pacific Telecommunications Council Mid-Year Seminar includes the following presentations: "Platform and Equipment for Access Network" (Yukou Mochida); "Integrated Services Television: Digital Age TV with a Built-in Home Server" (Tatsuhito Nagaya); "Future of the Internet: Future of…

Cost-utility analysis of varenicline, an oral smoking-cessation drug, in Japan.

PubMed

Igarashi, Ataru; Takuma, Hiroki; Fukuda, Takashi; Tsutani, Kiichiro

2009-01-01

To conduct a cost-utility analysis of two 12-week smoking-cessation interventions in Japan: smoking-cessation counselling by a physician compared with use of varenicline, an oral smoking-cessation drug, in addition to counselling. A Markov model was constructed to analyse lifetime medical costs and QALYs from the perspective of the healthcare payer. The cycle length was 5 years. Both costs and QALYs were discounted at 3% annually. The cohort of smokers was classified by sex and age, and we assumed that smokers started smoking at the age of 20 years and received smoking-cessation therapy at the ages of 30, 40, 50, 60 or 70 years (five separate models were run). The healthcare costs and QALYs were calculated throughout the term until the age of 90 years. In the base-case analysis, success rates of varenicline plus counselling and counselling alone were assumed to be 37.9% and 25.5%, respectively, in male smokers, and 22.2% and 16.1%, respectively, in female smokers, based on a randomized controlled trial conducted in Japan. Both univariate and probabilistic sensitivity analyses were conducted. Prescribed varenicline was shown to be more effective and less costly than smoking-cessation counselling alone. Varenicline would save direct medical costs of Japanese Yen (yen)43 846 ($US381; $US1 = yen115; Oct 2007) and generate an increase of 0.094 QALYs in male smokers. In females the incremental cost-effectiveness ratio was yen346 143 per QALY gained. Varenicline is estimated to save yen23.7 billion ($US206 million) of the medical costs for tobacco-associated diseases for the whole population. Overall savings are yen9.5 billion. Sensitivity analyses suggested the robustness of the results. As with any data of this nature, there is some uncertainty in the results and further research is warranted. However, based on the results of this pharmacoeconomic evaluation, varenicline, the first non-nicotine, oral treatment developed for smoking cessation, appears to be cost

Excision of uranium oxide chains and ribbons in the novel one-dimensional uranyl iodates K(2)[(UO(2))3(IO(3))(4)O(2)] and Ba[(UO(2)2(IO(3))(2)O(2)](H(2)O).

PubMed

Bean, A C; Ruf, M; Albrecht-Schmitt, T E

2001-07-30

The alkali metal and alkaline-earth metal uranyl iodates K(2)[(UO(2))(3)(IO(3))(4)O(2)] and Ba[(UO(2))(2)(IO(3))(2)O(2)](H(2)O) have been prepared from the hydrothermal reactions of KCl or BaCl(2) with UO(3) and I(2)O(5) at 425 and 180 degrees C, respectively. While K(2)[(UO(2))(3)(IO(3))(4)O(2)] can be synthesized under both mild and supercritical conditions, the yield increases from <5% to 73% as the temperature is raised from 180 to 425 degrees C. Ba[(UO(2))(2)(IO(3))(2)O(2)](H(2)O), however, has only been isolated from reactions performed in the mild temperature regime. Thermal measurements (DSC) indicate that K(2)[(UO(2))(3)(IO(3))(4)O(2)] is more stable than Ba[(UO(2))(2)(IO(3))(2)O(2)](H(2)O) and that both compounds decompose through thermal disproportionation at 579 and 575 degrees C, respectively. The difference in the thermal behavior of these compounds provides a basis for the divergence of their preparation temperatures. The structure of K(2)[(UO(2))(3)(IO(3))(4)O(2)] is composed of [(UO(2))(3)(IO(3))(4)O(2)](2)(-) chains built from the edge-sharing UO(7) pentagonal bipyramids and UO(6) octahedra. Ba[(UO(2))(2)(IO(3))(2)O(2)](H(2)O) consists of one-dimensional [(UO(2))(2)(IO(3))(2)O(2)](2)(-) ribbons formed from the edge sharing of distorted UO(7) pentagonal bipyramids. In both compounds the iodate groups occur in both bridging and monodentate binding modes and further serve to terminate the edges of the uranium oxide chains. The K(+) or Ba(2+) cations separate the chains or ribbons in these compounds forming bonds with terminal oxygen atoms from the iodate ligands. Crystallographic data: K(2)[(UO(2))(3)(IO(3))(4)O(2)], triclinic, space group P_1, a = 7.0372(5) A, b = 7.7727(5) A, c = 8.9851(6) A, alpha = 93.386(1) degrees, beta = 105.668(1) degrees, gamma = 91.339(1) degrees, Z = 1; Ba[(UO(2))(2)(IO(3))(2)O(2)](H(2)O), monoclinic, space group P2(1)/c, a = 8.062(4) A, b = 6.940(3) A, c = 21.67(1), beta= 98.05(1) degrees, Z = 4.

22 CFR 42.11 - Classification symbols.

Code of Federal Regulations, 2010 CFR

2010-04-01

...) F21 Spouse of Lawful Permanent Resident 203(a)(2)(A). F22 Child of Lawful Permanent Resident 203(a)(2)(A). F23 Child of F21 or F22 203(d) & 203(a)(2)(A). F24 Unmarried Son or Daughter of Lawful Permanent...

22 CFR 42.11 - Classification symbols.

Code of Federal Regulations, 2011 CFR

2011-04-01

...) F21 Spouse of Lawful Permanent Resident 203(a)(2)(A). F22 Child of Lawful Permanent Resident 203(a)(2)(A). F23 Child of F21 or F22 203(d) & 203(a)(2)(A). F24 Unmarried Son or Daughter of Lawful Permanent...

22 CFR 42.11 - Classification symbols.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) F21 Spouse of Lawful Permanent Resident 203(a)(2)(A). F22 Child of Lawful Permanent Resident 203(a)(2)(A). F23 Child of F21 or F22 203(d) & 203(a)(2)(A). F24 Unmarried Son or Daughter of Lawful Permanent...

22 CFR 42.11 - Classification symbols.

Code of Federal Regulations, 2014 CFR

2014-04-01

...) F21 Spouse of Lawful Permanent Resident 203(a)(2)(A). F22 Child of Lawful Permanent Resident 203(a)(2)(A). F23 Child of F21 or F22 203(d) & 203(a)(2)(A). F24 Unmarried Son or Daughter of Lawful Permanent...

22 CFR 42.11 - Classification symbols.

Code of Federal Regulations, 2012 CFR

2012-04-01

...) F21 Spouse of Lawful Permanent Resident 203(a)(2)(A). F22 Child of Lawful Permanent Resident 203(a)(2)(A). F23 Child of F21 or F22 203(d) & 203(a)(2)(A). F24 Unmarried Son or Daughter of Lawful Permanent...

Can Japan Contribute to the Post Millennium Development Goals? Making Human Security Mainstream through the TICAD Process

PubMed Central

Takahashi, Kenzo; Kobayashi, Jun; Nomura-Baba, Marika; Kakimoto, Kazuhiro; Nakamura, Yasuhide

2013-01-01

In 2013, the fifth Tokyo International Conference on African Development (TICAD V) will be hosted by the Japanese government. TICAD, which has been held every five years, has played a catalytic role in African policy dialogue and a leading role in promoting the human security approach (HSA). We review the development of the HSA in the TICAD dialogue on health agendas and recommend TICAD’s role in the integration of the HSA beyond the 2015 agenda. While health was not the main agenda in TICAD I and II, the importance of primary health care, and the development of regional health systems was noted in TICAD III. In 2008, when Japan hosted both the G8 summit and TICAD IV, the Takemi Working Group developed strong momentum for health in Africa. Their policy dialogues on global health in Sub-Saharan Africa incubated several recommendations highlighting HSA and health system strengthening (HSS). HSA is relevant to HSS because it focuses on individuals and communities. It has two mutually reinforcing strategies, a top-down approach by central or local governments (protection) and a bottom-up approach by individuals and communities (empowerment). The “Yokohama Action Plan,” which promotes HSA was welcomed by the TICAD IV member countries. Universal health coverage (UHC) is a major candidate for the post-2015 agenda recommended by the World Health Organization. We expect UHC to provide a more balanced approach between specific disease focus and system-based solutions. Japan’s global health policy is coherent with HSA because human security can be the basis of UHC-compatible HSS. PMID:24155655

Molecular epidemiology of Klebsiella pneumoniae K1 and K2 isolates in Japan.

PubMed

Harada, Sohei; Ishii, Yoshikazu; Saga, Tomoo; Aoki, Kotaro; Tateda, Kazuhiro

2018-03-20

Although severe infections caused by hypervirulent Klebsiella pneumoniae isolates, such as K1 isolates belonging to sequence type (ST) 23, have been a significant problem in Asian countries, epidemiology of these isolates in Japan remains unclear. We performed a nationwide molecular epidemiological study of K. pneumoniae K1 and K2 isolates in Japan. Of the 259K. pneumoniae isolates collected, 14 and 16 isolates were identified as capsular genotypes K1 and K2, respectively. All K1 isolates were ST23 or its closely related clones and showed high genetic similarity by pulsed-field gel electrophoresis (PFGE) and the DiversiLab system (DL). K2 isolates, belonging to ST14, ST25, ST65, ST86, and ST110, were more genetically diverse than K1 isolates. Isolates belonging to a specific ST showed identical virulence gene profiles with a few exceptions. PFGE and DL results using K1 and K2 isolates were generally in agreement. Copyright © 2018. Published by Elsevier Inc.

Effectiveness of rotavirus vaccines against hospitalisations in Japan.

PubMed

Fujii, Yoshiyuki; Noguchi, Atsuko; Miura, Shinobu; Ishii, Haruka; Nakagomi, Toyoko; Nakagomi, Osamu; Takahashi, Tsutomu

2017-07-11

In Japan, rotavirus hospitalisation occurs at a rate from 2.8 to 13.7 per 1000 child-years among children age less than 5 years, and it imposes a substantial burden to the healthcare system in the country. While both monovalent (RV1) and pentavalent (RV5) rotavirus vaccines are licensed in Japan, neither has been incorporated in the national infant immunization programme. In this study, we estimated vaccine effectiveness (VE) in Japan. This study was conducted in Yuri-Kumiai General Hospital located in a city in the north-western part of Japan. Age-eligible children for rotavirus vaccination were enrolled if they were hospitalized for rotavirus gastroenteritis between September 2013 and August 2016. Rotavirus gastroenteritis was defined by the detection of rotavirus antigen by immunochromatography. "Vaccinated" was defined as infant inoculated with at least one dose of either RV1 or RV5. A conditional logistic regression analysis was performed by modelling the year of birth, year of admission, residence of the children and vaccination status, and by matching the age of cases with that of test-negative controls. The adjusted odds ratio of the vaccinated over unvaccinated was then used to calculate VE in the formula of (1 - adjusted odds ratio) × 100. Out of the 244 patients enrolled, rotavirus antigen was detected in 55 (22.5%) of whom 10 (18.2%) were vaccinated, whereas 94 (49.7%) of 189 test-negative controls were vaccinated. During the study period, the vaccine uptake rate in the controls increased from 36.2% to 61.8%. On the other hand, the vaccination coverage over the three years was 64.2% in Yuri-Honjo city (three quarters of the catchment), and 91.4% in Nikaho city (one quarter of the catchment). The VE was calculated to be 70.4% (95% confidence interval: 36.0-86.4%, P = 0.002). The point estimate of the VE was lower but its 95% confidence interval overlaps those of the efficacies obtained from clinical trials in Japan. The rotavirus vaccine was

23 CFR 750.710 - Landmark signs.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Outdoor Advertising Control § 750.710 Landmark signs. (a) 23 U.S.C. 131(c) permits the existence of signs lawfully in existence on October 22, 1965, determined by the State, subject to the approval of the... artistic significance, the preservation of which is consistent with the purpose of 23 U.S.C. 131. (b...

23 CFR 750.710 - Landmark signs.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Outdoor Advertising Control § 750.710 Landmark signs. (a) 23 U.S.C. 131(c) permits the existence of signs lawfully in existence on October 22, 1965, determined by the State, subject to the approval of the... artistic significance, the preservation of which is consistent with the purpose of 23 U.S.C. 131. (b...

Characterization of the Structure and Membrane Interaction of the Antimicrobial Peptides Aurein 2.2 and 2.3 from Australian Southern Bell Frogs

PubMed Central

Pan, Yeang-Ling; Cheng, John T.-J.; Hale, John; Pan, Jinhe; Hancock, Robert E. W.; Straus, Suzana K.

2007-01-01

The structure and membrane interaction of the antimicrobial peptide aurein 2.2 (GLFDIVKKVVGALGSL-CONH2), aurein 2.3 (GLFDIVKKVVGAIGSL-CONH2), both from Litoria aurea, and a carboxy C-terminal analog of aurein 2.3 (GLFDIVKKVVGAIGSL-COOH) were studied to determine which features of this class of peptides are key to activity. Circular dichroism and solution-state NMR data indicate that all three peptides adopt an α-helical structure in the presence of trifluoroethanol or lipids such as 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and a 1:1 mixture of DMPC and 1,2-dimyristoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] (DMPG). Oriented circular dichroism was used to determine the orientation of the peptides in lipid bilayers over a range of concentrations (peptide/lipid molar ratios (P/L) = 1:15–1:120) in DMPC and 1:1 DMPC/DMPG, in the liquid crystalline state. The results demonstrate that in DMPC all three peptides are surface adsorbed over a range of low peptide concentrations but insert into the bilayers at high peptide concentrations. This finding is corroborated by 31P-solid-state NMR data of the three peptides in DMPC, which shows that at high peptide concentrations the peptides perturb the membrane. Oriented circular dichroism data of the aurein peptides in 1:1 DMPC/DMPG, on the other hand, show that the peptides with amidated C-termini readily insert into the membrane bilayers over the concentration range studied (P/L = 1:15–1:120), whereas the aurein 2.3 peptide with a carboxy C-terminus inserts at a threshold concentration of P/L* between 1:80 and 1:120. Overall, the data presented here suggest that all three peptides studied interact with phosphatidylcholine membranes in a manner which is similar to aurein 1.2 and citropin 1.1, as reported in the literature, with no correlation to the reported activity. On the other hand, both aurein 2.2 and aurein 2.3 behave similarly in phosphatidylcholine/phosphatidylglycerol (PC/PG) membranes, whereas aurein 2.3

Characterization of the structure and membrane interaction of the antimicrobial peptides aurein 2.2 and 2.3 from Australian southern bell frogs.

PubMed

Pan, Yeang-Ling; Cheng, John T-J; Hale, John; Pan, Jinhe; Hancock, Robert E W; Straus, Suzana K

2007-04-15

The structure and membrane interaction of the antimicrobial peptide aurein 2.2 (GLFDIVKKVVGALGSL-CONH(2)), aurein 2.3 (GLFDIVKKVVGAIGSL-CONH(2)), both from Litoria aurea, and a carboxy C-terminal analog of aurein 2.3 (GLFDIVKKVVGAIGSL-COOH) were studied to determine which features of this class of peptides are key to activity. Circular dichroism and solution-state NMR data indicate that all three peptides adopt an alpha-helical structure in the presence of trifluoroethanol or lipids such as 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and a 1:1 mixture of DMPC and 1,2-dimyristoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] (DMPG). Oriented circular dichroism was used to determine the orientation of the peptides in lipid bilayers over a range of concentrations (peptide/lipid molar ratios (P/L) = 1:15-1:120) in DMPC and 1:1 DMPC/DMPG, in the liquid crystalline state. The results demonstrate that in DMPC all three peptides are surface adsorbed over a range of low peptide concentrations but insert into the bilayers at high peptide concentrations. This finding is corroborated by (31)P-solid-state NMR data of the three peptides in DMPC, which shows that at high peptide concentrations the peptides perturb the membrane. Oriented circular dichroism data of the aurein peptides in 1:1 DMPC/DMPG, on the other hand, show that the peptides with amidated C-termini readily insert into the membrane bilayers over the concentration range studied (P/L = 1:15-1:120), whereas the aurein 2.3 peptide with a carboxy C-terminus inserts at a threshold concentration of P/L* between 1:80 and 1:120. Overall, the data presented here suggest that all three peptides studied interact with phosphatidylcholine membranes in a manner which is similar to aurein 1.2 and citropin 1.1, as reported in the literature, with no correlation to the reported activity. On the other hand, both aurein 2.2 and aurein 2.3 behave similarly in phosphatidylcholine/phosphatidylglycerol (PC/PG) membranes, whereas aurein

Unusual X-chromosome inactivation pattern in patients with Xp11.23-p11.22 duplication: Report and review.

PubMed

Di-Battista, Adriana; Meloni, Vera Ayres; da Silva, Magnus Dias; Moysés-Oliveira, Mariana; Melaragno, Maria Isabel

2016-12-01

In females carrying structural rearrangements of an X-chromosome, cells with the best dosage balance are preferentially selected, frequently resulting in a skewed inactivation pattern and amelioration of the phenotype. The Xp11.23-p11.22 region is involved in a recently described microduplication syndrome associated with severe clinical consequences in males and females, causing intellectual disability, behavior problems, epilepsy with electroencephalogram anomalies, minor facial anomalies, and early onset of puberty. Female carriers usually present an unusual X-chromosome inactivation pattern in favor of the aberrant chromosome, resulting in functional disomy of the duplicated segment. Here, we describe a girl carrying a de novo ∼9.7 Mb Xp11.3-p11.22 duplication of paternal origin and skewed X-chromosome inactivation pattern of the normal X-chromosome. We reviewed other cases previously reported and determined the minimal critical region possibly responsible for this unusual inactivation pattern. The critical region encompasses 36 RefSeq genes, including at least 10 oncogenes and/or genes related to the cell cycle control. We discuss the molecular mechanisms that underlie the positive selection of the cells with the active duplicated chromosome. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Design characteristics of the Corrona Japan rheumatoid arthritis registry.

PubMed

Yamanaka, Hisashi; Kishimoto, Mitsumasa; Pappas, Dimitrios A; Greenberg, Jeffrey D; Kremer, Joel M; Tanaka, Yoshiya

2018-01-01

The primary objective is to prospectively study the comparative safety and effectiveness of older and newer classes of nonbiologic DMARDs (Disease-modifying antirheumatic drugs), biologic DMARDs and targeted synthetic therapies approved for rheumatoid arthritis (RA) in a real-world patient population in Japan. Prospective, multicenter, noninterventional, observational study across geographic distribution of both private and public institutions for patients with RA who are newly prescribed one of the following medications: (1) methotrexate; (2) anti-TNF biologic DMARDs; (3) non-TNF biologic DMARDs; and (4) approved JAK inhibitors at the time of enrollment into the registry. Target enrollment is currently 2000 subjects. Baseline and follow-up data on patient demographics, medical history, disease activity, laboratory results, comorbidities, hospitalizations, and targeted safety events are obtained via Physician and Patient Questionnaires. Fifty sites are anticipated to participate with 40 sites ethics committee (EC) approved at the time of submission consisting of 23% clinics, 21% private academic hospitals, 29% private mid-sized to large hospitals, 15% national academic hospitals, and 12% national hospitals. The Corrona Japan RA Registry will provide real-world evidence from both private and public institutions on the comparative effectiveness and safety of recently approved RA therapies in Japan.

Extraction and Refinement Strategy for detection of autism in 18-month-olds: a guarantee of higher sensitivity and specificity in the process of mass screening.

PubMed

Honda, Hideo; Shimizu, Yasuo; Nitto, Yukari; Imai, Miho; Ozawa, Takeshi; Iwasa, Mitsuaki; Shiga, Keiko; Hira, Tomoko

2009-08-01

For early detection of autism, it is difficult to maintain an efficient level of sensitivity and specificity based on observational data from a single screening. The Extraction and Refinement (E&R) Strategy utilizes a public children's health surveillance program to produce maximum efficacy in early detection of autism. In the extraction stage, all cases at risk of childhood problems, including developmental abnormality, are identified; in the refinement stage, cases without problems are excluded, leaving only cases with conclusive diagnoses. The city of Yokohama, Japan, conducts a routine child health surveillance program for children at 18 months in which specialized public health nurses administer YACHT-18 (Young Autism and other developmental disorders CHeckup Tool), a screening instrument to identify children at risk for developmental disorders. Children who screen positive undergo further observation, and those without disorders are subsequently excluded. To study the efficacy of early detection procedures for developmental disorders, including autism, 2,814 children born in 1988, examined at 18 months of age, and not already receiving treatment for diseases or disorders were selected. In the extraction stage, 402 (14.3%) children were identified for follow-up. In the refinement stage, 19 (.7%) of these were referred to the Yokohama Rehabilitation Center and diagnosed with developmental disorders. The extraction stage produced four false negatives, bringing total diagnoses of developmental disorders to 23 (.8%) - including 5 with autistic disorder and 9 with pervasive developmental disorder - not otherwise specified (PDDNOS). Sensitivity was 60% for autistic disorder and 82.6% for developmental disorders. Specificity for developmental disorders rose to 100% with the E&R Strategy. Picture cards used in YACHT-18 provided a finer screen that excluded some false positive cases. An extraction and refinement methodology utilizing child health surveillance programs

Hematological malignancies with t(9;11)(p21-22;q23)--a laboratory and clinical study of 125 cases. European 11q23 Workshop participants.

PubMed

Swansbury, G J; Slater, R; Bain, B J; Moorman, A V; Secker-Walker, L M

1998-05-01

This paper reports clinical and cytogenetic data from 125 cases with t(9;11)(p21-22;q32) which were accepted for a European Union Concerted Action Workshop on 11q23. This chromosome abnormality is known to occur predominantly in acute myeloid leukemia (AML) FAB type M5a and less often in AML M4; in this series it was also found to occur, uncommonly, in other AML FAB types, in childhood acute lymphoblastic leukemia (ALL) (nine cases), in relatively young patients with myelodysplastic syndrome (MDS) (five cases), acute biphenotypic leukemia (two cases), and acute undifferentiated leukemia (one case). All age groups were represented but 50% of the patients were aged less than 15 years. The t(9;11) was the sole abnormality in 57 cases with AML; trisomy 8 was the most common additional abnormality (23 cases, including seven with further abnormalities), and 28 cases had other additional abnormalities. Among the t(9;11)+ve patients with AML, the white cell count (WBC) and age group were significant predictors of event-free survival; central nervous system (CNS) involvement or karyotype class (sole, with trisomy 8, or with other), also contributed to prognosis although our data could not show these to be independent factors. The best outcome was for patients aged 1-9 years, with low WBC, and with absence of CNS disease or presence of trisomy 8. For patients aged less than 15 years, the event-free survival for ALL patients was not significantly worse than that of AML patients.

A balanced t(5;17) (p15;q22-23) in chondroblastoma: frequency of the re-arrangement and analysis of the candidate genes

PubMed Central

2009-01-01

Background Chondroblastoma is a benign cartilaginous tumour of bone that predominantly affects the epiphysis of long bones in young males. No recurrent chromosomal re-arrangements have so far been observed. Methods: We identified an index case with a balanced translocation by Combined Binary Ratio-Fluorescent in situ Hybridisation (COBRA-FISH) karyotyping followed by breakpoint FISH mapping and array-Comparative Genomic Hybridisation (aCGH). Candidate region re-arrangement and candidate gene expression were subsequently investigated by interphase FISH and immunohistochemistry in another 14 cases. Results A balanced t(5;17)(p15;q22-23) was identified. In the index case, interphase FISH showed that the translocation was present only in mononucleated cells and was absent in the characteristic multinucleated giant cells. The t(5;17) translocation was not observed in the other cases studied. The breakpoint in 5p15 occurred close to the steroid reductase 5α1 (SRD5A1) gene. Expression of the protein was found in all cases tested. Similar expression was found for the sex steroid signalling-related molecules oestrogen receptor alpha and aromatase, while androgen receptors were only found in isolated cells in a few cases. The breakpoint in 17q22-23 was upstream of the carbonic anhydrase × (CA10) gene region and possibly involved gene-regulatory elements, which was indicated by the lack of CA10 protein expression in the index case. All other cases showed variable levels of CA10 expression, with low expression in three cases. Conclusion We report a novel t(5;17)(p15;q22-23) translocation in chondroblastoma without involvement of any of the two chromosomal regions in other cases studied. Our results indicate that the characteristic multinucleated giant cells in chondroblastoma do not have the same clonal origin as the mononuclear population, as they do not harbour the same translocation. We therefore hypothesise that they might be either reactive or originate from a distinct

49 CFR 218.22 - Utility employee.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Blue Signal Protection of Workers § 218.22 Utility... railroad rolling equipment must be provided with blue signal protection in accordance with §§ 218.23... provided blue signal protection in accordance with §§ 218.23 through 218.30 of this part. (h) Nothing in...

49 CFR 218.22 - Utility employee.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Blue Signal Protection of Workers § 218.22 Utility... railroad rolling equipment must be provided with blue signal protection in accordance with §§ 218.23... provided blue signal protection in accordance with §§ 218.23 through 218.30 of this part. (h) Nothing in...

Progress towards mapping the constitutional t(11:22) breakpoint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barnoski, B.L.; Emanuel, B.S.; Bell, C.J.

1994-09-01

The reciprocal t(11;22)(q23;q11) is the most frequent, recurrent, non-Robertsonian, constitutional translocation in humans. Balanced carriers of this rearrangement are phenotypically normal, but are at risk for producing abnormal offspring with the Supernumerary der(22)t(11;22) Syndrome. Further, a recent report of association between t(11;22) balanced translocation carriers and breast cancer, suggests the involvement of genes on 11q and/or 22q in breast cancer tumorigenesis. Studies are in progress to examine the similarity between 11q23 and 22q11 breakpoints in multiple families with the constitutional t(11;22). A 750 kb YAC, which contains markers known to flank the 11q23 breakpoint, was identified in CEPH/Genethon database. FISHmore » with this YAC to two independent t(11;22) cell lines demonstrates signal on both derivative chromosomes. Numerous YACs containing BCRL2, the closest marker proximal to the breakpoint, were identified. Analysis of these YACs to determine which contain the actual breakpoint sequences is complicated by the presence of a duplicated segment of 22q11 which contains a GGTL and a BCRL locus. Sequences homologous to these loci are present at several other locations in 22q11. The BCRL positive YACs were analyzed by Southern hybridization under conditions which distinguish the four members of the BCR/BCRL family. FISH of total yeast DNA plus YAC DNA labeled by nick translation, or biotin-labeled inter-Alu PCR products confirmed the localization of these YACs to 22q11. Additional FISH with these YACS to metaphase spreads prepared from balanced t(11;22) carriers confirm that these clones span the breakpoint, and will allow rapid isolation and definition of the genetic region adjacent to the t(11;22) breakpoint.« less

ATM function and its relationship with ATM gene mutations in chronic lymphocytic leukemia with the recurrent deletion (11q22.3-23.2).

PubMed

Jiang, Y; Chen, H-C; Su, X; Thompson, P A; Liu, X; Do, K-A; Wierda, W; Keating, M J; Plunkett, W

2016-09-02

Approximately 10-20% of chronic lymphocytic leukemia (CLL) patients exhibit del(11q22-23) before treatment, this cohort increases to over 40% upon progression following chemoimmunotherapy. The coding sequence of the DNA damage response gene, ataxia-telangiectasia-mutated (ATM), is contained in this deletion. The residual ATM allele is frequently mutated, suggesting a relationship between gene function and clinical response. To investigate this possibility, we sought to develop and validate an assay for the function of ATM protein in these patients. SMC1 (structural maintenance of chromosomes 1) and KAP1 (KRAB-associated protein 1) were found to be unique substrates of ATM kinase by immunoblot detection following ionizing radiation. Using a pool of eight fluorescence in situ hybridization-negative CLL samples as a standard, the phosphorylation of SMC1 and KAP1 from 46 del (11q22-23) samples was analyzed using normal mixture model-based clustering. This identified 13 samples (28%) that were deficient in ATM function. Targeted sequencing of the ATM gene of these samples, with reference to genomic DNA, revealed 12 somatic mutations and 15 germline mutations in these samples. No strong correlation was observed between ATM mutation and function. Therefore, mutation status may not be taken as an indicator of ATM function. Rather, a direct assay of the kinase activity should be used in the development of therapies.

Database and Related Activities in Japan

NASA Astrophysics Data System (ADS)

Murakami, Izumi; Kato, Daiji; Kato, Masatoshi; Sakaue, Hiroyuki A.; Kato, Takako; Ding, Xiaobin; Morita, Shigeru; Kitajima, Masashi; Koike, Fumihiro; Nakamura, Nobuyuki; Sakamoto, Naoki; Sasaki, Akira; Skobelev, Igor; Tsuchida, Hidetsugu; Ulantsev, Artemiy; Watanabe, Tetsuya; Yamamoto, Norimasa

2011-05-01

We have constructed and made available atomic and molecular (AM) numerical databases on collision processes such as electron-impact excitation and ionization, recombination and charge transfer of atoms and molecules relevant for plasma physics, fusion research, astrophysics, applied-science plasma, and other related areas. The retrievable data is freely accessible via the internet. We also work on atomic data evaluation and constructing collisional-radiative models for spectroscopic plasma diagnostics. Recently we have worked on Fe ions and W ions theoretically and experimentally. The atomic data and collisional-radiative models for these ions are examined and applied to laboratory plasmas. A visible M1 transition of W26+ ion is identified at 389.41 nm by EBIT experiments and theoretical calculations. We have small non-retrievable databases in addition to our main database. Recently we evaluated photo-absorption cross sections for 9 atoms and 23 molecules and we present them as a new database. We established a new association "Forum of Atomic and Molecular Data and Their Applications" to exchange information among AM data producers, data providers and data users in Japan and we hope this will help to encourage AM data activities in Japan.

In Vitro and In Vivo Human Metabolism of Synthetic Cannabinoids FDU-PB-22 and FUB-PB-22.

PubMed

Diao, Xingxing; Scheidweiler, Karl B; Wohlfarth, Ariane; Pang, Shaokun; Kronstrand, Robert; Huestis, Marilyn A

2016-03-01

In 2014, FDU-PB-22 and FUB-PB-22, two novel synthetic cannabinoids, were detected in herbal blends in Japan, Russia, and Germany and were quickly added to their scheduled drugs list. Unfortunately, no human metabolism data are currently available, making it challenging to confirm their intake. The present study aims to identify appropriate analytical markers by investigating FDU-PB-22 and FUB-PB-22 metabolism in human hepatocytes and confirm the results in authentic urine specimens. For metabolic stability, 1 μM FDU-PB-22 and FUB-PB-22 was incubated with human liver microsomes for up to 1 h; for metabolite profiling, 10 μM was incubated with human hepatocytes for 3 h. Two authentic urine specimens from FDU-PB-22 and FUB-PB-22 positive cases were analyzed after β-glucuronidase hydrolysis. Metabolite identification in hepatocyte samples and urine specimens was accomplished by high-resolution mass spectrometry using information-dependent acquisition. Both FDU-PB-22 and FUB-PB-22 were rapidly metabolized in HLM with half-lives of 12.4 and 11.5 min, respectively. In human hepatocyte samples, we identified seven metabolites for both compounds, generated by ester hydrolysis and further hydroxylation and/or glucuronidation. After ester hydrolysis, FDU-PB-22 and FUB-PB-22 yielded the same metabolite M7, fluorobenzylindole-3-carboxylic acid (FBI-COOH). M7 and M6 (hydroxylated FBI-COOH) were the major metabolites. In authentic urine specimens after β-glucuronidase hydrolysis, M6 and M7 also were the predominant metabolites. Based on our study, we recommend M6 (hydroxylated FBI-COOH) and M7 (FBI-COOH) as suitable urinary markers for documenting FDU-PB-22 and/or FUB-PB-22 intake.

A longitudinal study of disturbances of the hypothalamic-pituitary-adrenal axis in women with progestin-negative functional hypothalamic amenorrhea.

PubMed

Kondoh, Y; Uemura, T; Murase, M; Yokoi, N; Ishikawa, M; Hirahara, F

2001-10-01

To longitudinally evaluate disturbances of the hypothalamic-pituitary-adrenal (HPA) axis in women with secondary progestin-negative hypothalamic amenorrhea. Retrospective cohort study. Yokohama City University, Yokohama, Japan. Twenty-four women with progestin-negative hypothalamic amenorrhea. Administration of human corticotropin-releasing hormone (hCRH) and treatment with a combination of estrogen and progesterone. Plasma cortisol and ACTH concentrations and period required for recovery from amenorrhea. Plasma ACTH concentrations 30 and 60 minutes after injection of hCRH and the percent maximum increment (%Cmax) of ACTH were significantly lower in the amenorrheic patients compared with the control group patients. The basal cortisol was significantly higher, and the %Cmax of cortisol was significantly lower. In the 16 patients who recovered from amenorrhea, there was a significant positive correlation (Y = 1.93X-10.8, r = 0.629) between the basal cortisol concentrations (X) and the period for recovery (Y). The serum E2 gradually increased before recovery, and this E2 increase was preceded by changes in the plasma cortisol concentration and the %Cmax values of cortisol and ACTH. The CRH test might be useful for evaluating the roles of stress and for estimating the period required for recovery in hypothalamic amenorrhea.

PREFACE: Fullerene Nano Materials (Symposium of IUMRS-ICA2008)

NASA Astrophysics Data System (ADS)

Miyazawa, Kun'ichi; Fujita, Daisuke; Wakahara, Takatsugu; Kizuka, Tokushi; Matsuishi, Kiyoto; Ochiai, Yuichi; Tachibana, Masaru; Ogata, Hironori; Mashino, Tadahiko; Kumashiro, Ryotaro; Oikawa, Hidetoshi

2009-07-01

This volume contains peer-reviewed invited and contributed papers that were presented in Symposium N 'Fullerene Nano Materials' at the IUMRS International Conference in Asia 2008 (IUMRS-ICA 2008), which was held on 9-13 December 2008, at Nagoya Congress Center, Nagoya, Japan. Over twenty years have passed since the discovery of C60 in 1985. The discovery of superconductivity of C60 in 1991 suggested infinite possibilities for fullerenes. On the other hand, a new field of nanocarbon has been developed recently, based on novel functions of the low-dimensional fullerene nanomaterials that include fullerene nanowhiskers, fullerene nanotubes, fullerene nanosheets, chemically modified fullerenes, endohedral fullerenes, thin films of fullerenes and so forth. Electrical, electrochemical, optical, thermal, mechanical and various other properties of fullerene nanomaterials have been investigated and their novel and anomalous nature has been reported. Biological properties of fullerene nanomaterials also have been investigated both in medical applications and toxicity aspects. The recent research developments of fullerene nanomaterials cover a variety of categories owing to their functional diversity. This symposium aimed to review the progress in the state-of-the-art technology based on fullerenes and to offer the forum for active interdisciplinary discussions. 24 oral papers containing 8 invited papers and 22 poster papers were presented at the two-day symposium. Topics on the social acceptance of nanomaterials including fullerene were presented on the first day of the symposium. Biological impacts of nanomaterials and the importance of standardization of nanomaterials characterization were also shown. On the second day, the synthesis, properties, functions and applications of various fullerene nanomaterials were shown in both the oral and poster presentations. We are grateful to all invited speakers and many participants for valuable contributions and active discussions

40 CFR 145.22 - Elements of a program submission.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Elements of a program submission. 145.22 Section 145.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE UIC PROGRAM REQUIREMENTS State Program Submissions § 145.22 Elements of a...

40 CFR 145.22 - Elements of a program submission.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 23 2014-07-01 2014-07-01 false Elements of a program submission. 145.22 Section 145.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE UIC PROGRAM REQUIREMENTS State Program Submissions § 145.22 Elements of a...

USH1H, a novel locus for type I Usher syndrome, maps to chromosome 15q22-23.

PubMed

Ahmed, Z M; Riazuddin, S; Khan, S N; Friedman, P L; Riazuddin, S; Friedman, T B

2009-01-01

Usher syndrome (USH) is a hereditary disorder associated with sensorineural hearing impairment, progressive loss of vision attributable to retinitis pigmentosa (RP) and variable vestibular function. Three clinical types have been described with type I (USH1) being the most severe. To date, six USH1 loci have been reported. We ascertained two large Pakistani consanguineous families segregating profound hearing loss, vestibular dysfunction, and RP, the defining features of USH1. In these families, we excluded linkage of USH to the 11 known USH loci and subsequently performed a genome-wide linkage screen. We found a novel USH1 locus designated USH1H that mapped to chromosome 15q22-23 in a 4.92-cM interval. This locus overlaps the non-syndromic deafness locus DFNB48 raising the possibility that the two disorders may be caused by allelic mutations.

16 CFR 23.13 - Disclosure of treatments to diamonds

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Disclosure of treatments to diamonds 23.13... JEWELRY, PRECIOUS METALS, AND PEWTER INDUSTRIES § 23.13 Disclosure of treatments to diamonds A diamond is a gemstone product. Treatments to diamonds should be disclosed in the manner prescribed in § 23.22...

16 CFR 23.13 - Disclosure of treatments to diamonds.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Disclosure of treatments to diamonds. 23.13... JEWELRY, PRECIOUS METALS, AND PEWTER INDUSTRIES § 23.13 Disclosure of treatments to diamonds. A diamond is a gemstone product. Treatments to diamonds should be disclosed in the manner prescribed in § 23.22...

16 CFR 23.13 - Disclosure of treatments to diamonds

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Disclosure of treatments to diamonds 23.13... JEWELRY, PRECIOUS METALS, AND PEWTER INDUSTRIES § 23.13 Disclosure of treatments to diamonds A diamond is a gemstone product. Treatments to diamonds should be disclosed in the manner prescribed in § 23.22...

16 CFR 23.13 - Disclosure of treatments to diamonds.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Disclosure of treatments to diamonds. 23.13... JEWELRY, PRECIOUS METALS, AND PEWTER INDUSTRIES § 23.13 Disclosure of treatments to diamonds. A diamond is a gemstone product. Treatments to diamonds should be disclosed in the manner prescribed in § 23.22...

16 CFR 23.13 - Disclosure of treatments to diamonds.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Disclosure of treatments to diamonds. 23.13... JEWELRY, PRECIOUS METALS, AND PEWTER INDUSTRIES § 23.13 Disclosure of treatments to diamonds. A diamond is a gemstone product. Treatments to diamonds should be disclosed in the manner prescribed in § 23.22...

Unique characteristics of community-onset healthcare- associated bloodstream infections: a multi-centre prospective surveillance study of bloodstream infections in Japan.

PubMed

Takeshita, N; Kawamura, I; Kurai, H; Araoka, H; Yoneyama, A; Fujita, T; Ainoda, Y; Hase, R; Hosokawa, N; Shimanuki, H; Sekiya, N; Ohmagari, N

2017-05-01

Analysis of bloodstream infections (BSIs) is valuable for their diagnosis, treatment and prevention. However, limited data are available in Japan. To investigate the characteristics of patients with bacteraemia in Japan. This study was conducted in five hospitals from October 2012 to September 2013. Clinical, demographic, microbiological and outcome data for all blood-culture-positive cases were analysed. In total, 3206 cases of BSI were analysed: 551 community-onset healthcare-associated (CHA)-BSIs, 1891 hospital-acquired (HA)-BSIs and 764 community-acquired (CA)-BSIs. The seven- and 30-day mortality rates were higher in patients with CHA- and HA-BSIs than in patients with CA-BSIs. The odds ratios (ORs) for seven-day mortality were 2.56 [95% confidence interval (CI) 1.48-4.41] and 2.63 (95% CI 1.64-4.19) for CHA- and HA-BSIs, respectively. The ORs for 30-day mortality were 2.41 (95% CI 1.63-3.57) and 3.31 (95% CI 2.39-4.59) for CHA- and HA-BSIs, respectively. There were 499 cases (15.2%) of central-line-associated BSI and 163 cases (5.0%) of peripheral-line-associated BSI. Major pathogens included coagulase-negative staphylococci (N = 736, 23.0%), Escherichia coli (N = 581, 18.1%), Staphylococcus aureus (N = 294, 9.2%) and Klebsiella pneumoniae (N = 263, 8.2%). E. coli exhibited a higher 30-day mortality rate among patients with HA-BSIs (22.3%) compared with patients with CHA-BSIs (12.3%) and CA-BSIs (3.4%). K. pneumoniae exhibited higher 30-day mortality rates in patients with HA-BSIs (22.0%) and CHA-BSIs (22.7%) compared with patients with CA-BSIs (7.8%). CHA- and HA-BSIs had higher mortality rates than CA-BSIs. The prognoses of E. coli- and K. pneumonia-related BSIs differed according to the category of bacteraemia. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Measurement of the strengths of the resonances at 417, 458, 611, 632 and 1222 keV in the 22Ne(p, γ)23Na reaction

NASA Astrophysics Data System (ADS)

Ferraro, Federico

2018-01-01

The 22Ne(p, γ)23Na reaction is part of the NeNa cycle of hydrogen burning. This cycle plays a key role in the nucleosynthesis of the elements between 20Ne and 27Al in red giant stars, asymptotic giant stars and classical nova explosions. The strengths of the resonances at proton energies above 400 keV are still affected by high uncertainty. In order to reduce this uncertainty, a precision study of some of the most intense resonances between 400 keV and 1250 keV has been performed at the HZDR 3 MV Tandetron. The target, made of 22Ne implanted in a 0.22 mm thick Ta backing, has been characterized using the 1222 keV and 458 keV resonances, well known in literature. Subsequently, the strengths of the resonances at 417, 458, 611, 632 and 1222 keV were determined. Two HPGe detectors equipped with active anti-Compton shielding have been used.

Highlights from the Tenth International Symposium of Thrombosis and Anticoagulation (ISTA X), September 22 and 23, 2017, Salvador, Bahia, Brazil.

PubMed

Lopes, Renato D; Guimarães, Patricia O; Crowther, Mark; Hylek, Elaine; Feitosa-Filho, Gilson S; Ritt, Luiz E; Filgueiras, Nivaldo; Garcia, David A

2018-05-01

To discuss and share knowledge about advances in the care of patients with thrombotic disorders, the Tenth International Symposium of Thrombosis and Anticoagulation was held in Salvador, Bahia, Brazil, on September 22 and 23, 2017. This scientific program was developed by clinicians for clinicians and was promoted by two major clinical research institutes-the Brazilian Clinical Research Institute and the Duke Clinical Research Institute of the Duke University School of Medicine. Comprising academic presentations and open discussion, the symposium had as its primary goal to educate, motivate, and inspire internists, cardiologists, hematologists, and other physicians by convening national and international visionaries, thought-leaders, and dedicated clinician-scientists. This paper summarizes the symposium proceedings.

Evaluation of Gust and Draft Velocities from Flights of P-61C Airplanes within Thunderstorms July 22, 1946 to July 23, 1946 at Orlando, Florida

NASA Technical Reports Server (NTRS)

Tolefson, H. B.

1947-01-01

The results obtained from measurements of gust and draft velocities within thunderstorms for the period July 22, 1946 to July 23, 1946 at Orlando, Florida, are presented herein. These data are summarized in tables I and II, respectively, and are of the type presented in reference 1 for previous flights. Inspection of photo-observer records for the flights indicated that no data on ambient air temperature variations within thunderstorms were obtained.

Meiotic Recombination and Spatial Proximity in the Etiology of the Recurrent t(11;22)

PubMed Central

Ashley, Terry; Gaeth, Ann P.; Inagaki, Hidehito; Seftel, Allen; Cohen, Maimon M.; Anderson, Lorinda K.; Kurahashi, Hiroki; Emanuel, Beverly S.

2006-01-01

Although balanced translocations are among the most common human chromosomal aberrations, the constitutional t(11;22)(q23;q11) is the only known recurrent non-Robertsonian translocation. Evidence indicates that de novo formation of the t(11;22) occurs during meiosis. To test the hypothesis that spatial proximity of chromosomes 11 and 22 in meiotic prophase oocytes and spermatocytes plays a role in the rearrangement, the positions of the 11q23 and 22q11 translocation breakpoints were examined. Fluorescence in situ hybridization with use of DNA probes for these sites demonstrates that 11q23 is closer to 22q11 in meiosis than to a control at 6q26. Although chromosome 21p11, another control, often lies as close to 11q23 as does 22q11 during meiosis, chromosome 21 rarely rearranges with 11q23, and the DNA sequence of chromosome 21 appears to be less susceptible than 22q11 to double-strand breaks (DSBs). It has been suggested that the rearrangement recurs as a result of the palindromic AT-rich repeats at both 11q23 and 22q11, which extrude hairpin structures that are susceptible to DSBs. To determine whether the DSBs at these sites coincide with normal hotspots of meiotic recombination, immunocytochemical mapping of MLH1, a protein involved in crossing over, was employed. The results indicate that the translocation breakpoints do not coincide with recombination hotspots and therefore are unlikely to be the result of meiotic programmed DSBs, although MRE11 is likely to be involved. Previous analysis indicated that the DSBs appear to be repaired by a mechanism similar to nonhomologous end joining (NHEJ), although NHEJ is normally suppressed during meiosis. Taken together, these studies support the hypothesis that physical proximity between 11q23 and 22q11—but not typical meiotic recombinational activity in meiotic prophase—plays an important role in the generation of the constitutional t(11;22) rearrangement. PMID:16909390

Disaster Vulnerability of Hospitals: A Nationwide Surveillance in Japan.

PubMed

Ochi, Sae; Kato, Shigeaki; Kobayashi, Kenichi; Kanatani, Yasuhiro

2015-12-01

Hospital preparedness against disasters is key to achieving disaster mitigation for health. To gain a holistic view of hospitals in Japan, one of the most disaster-prone countries, a nationwide surveillance of hospital preparedness was conducted. A cross-sectional, paper-based interview was conducted that targeted all of the 8701 registered hospitals in Japan. Preparedness was assessed with regard to local hazards, compliance to building code, and preparation of resources such as electricity, water, communication tools, and transportation tools. Answers were obtained from 6122 hospitals (response rate: 70.3%), among which 20.5% were public (national or city-run) hospitals and others were private. Eight percent were the hospitals assigned as disaster-base hospitals and the others were non-disaster-base hospitals. Overall compliance to building code, power generators, water tanks, emergency communication tools, and helicopter platforms was 90%, 84%, 95%, 43%, and 22%, respectively. Major vulnerabilities in logistics in mega-cities and stockpiles required for chronic care emerged from the results of this nationwide surveillance of hospitals in Japan. To conduct further intensive surveillance to meet community health needs, appropriate sampling methods should be established on the basis of this preliminary study. Holistic vulnerability analysis of community hospitals will lead to more robust disaster mitigation at the local level.

The present situation of the irradiation application industry and irradiation facilities in Japan

NASA Astrophysics Data System (ADS)

Mizusawa, K.; Baba, T.

2003-08-01

The irradiation application industry and irradiation facilities in Japan have been making slow but steady progress for the past 2-3 years. Beside conventional applications, new ones such as carbon fibers and membrane filters have come into the market. There are a lot of new applications about to emerge. PE tubing, already is in the European market, is being evaluated by end users in Japan. Cleaning of dioxin in exhaust gas was successfully tested at a pilot plant. Cross-linked PTFE and polyamide are waiting customers' evaluations as an engineering plastic. Surface cross-linking of artificial polycarbonate teeth has yielded remarkable experimental results. Cross-linking of polycaprolactone will be useful for biodegradable products. Being aware of the future growth of irradiation industry, contract service providers opened new facilities or increased their capability. Beside in-house facilities, there are now three Co-60 facilities and nine EB facilities available for contract irradiation in Japan.

Survey of tick-borne zoonotic viruses in wild deer in Hokkaido, Japan.

PubMed

Uchida, Leo; Hayasaka, Daisuke; Ngwe Tun, Mya Myat; Morita, Kouichi; Muramatsu, Yasukazu; Hagiwara, Katsuro

2018-04-19

Tick-borne encephalitis (TBE) and severe fever with thrombocytopenia syndrome (SFTS) are both tick-borne zoonotic diseases caused by TBE virus (TBEV) and SFTS phlebovirus (SFTSV). In 2016, a second domestic TBE case was reported in Hokkaido, Japan, after an absence of 23 years. We conducted IgG ELISA for TBEV and SFTSV on 314 deer (Cervus nippon yesoensis) serum samples collected from 3 places in Hokkaido. There were 7 seropositive samples for TBEV but none for SFTSV by ELISA. The specificity of the 7 positive samples was confirmed by neutralization tests against TBEV, and 5 sera showed 320 to 640 of 50% focus reduction endpoint titers. Our results provide information about the infectious status of TBEV in wild deer in Hokkaido, Japan.

Reconsidering Japan's underperformance in pharmaceuticals: evidence from Japan's anticancer drug sector.

PubMed

Umemura, Maki

2010-01-01

Unlike its automobile or electronics industries, Japan's pharmaceutical industry did not become a global leader. Japan remains a net importer of pharmaceuticals and has introduced few global blockbuster drugs. Alfred Chandler argued that Japan's pharmaceutical firms remained relatively weak because Western firms enjoyed an insurmountable first first-mover advantage. However, this case study of the anticancer drug sector illustrates that Chandler's explanation is incomplete. Japanese medical culture, government policy, and research environment also played a substantial role in shaping the industry. In the 1970s and 1980s, these factors encouraged firms to develop little few effective drugs with low side effects, and profit from Japan's domestic market. But, these drugs were unsuitable to foreign markets with more demanding efficacy standards. As a result, Japan not only lost more than a decade in developing ineffective drugs, but also neglected to create the infrastructure necessary to develop innovative drugs and build a stronger pharmaceutical industry.

The Japan Flavour and Fragrance Materials Association's (JFFMA) safety assessment of acetal food flavouring substances uniquely used in Japan.

PubMed

Okamura, Hiroyuki; Abe, Hajime; Hasegawa-Baba, Yasuko; Saito, Kenji; Sekiya, Fumiko; Hayashi, Shim-Mo; Mirokuji, Yoshiharu; Maruyama, Shinpei; Ono, Atsushi; Nakajima, Madoka; Degawa, Masakuni; Ozawa, Shogo; Shibutani, Makoto; Maitani, Tamio

2015-01-01

Using the procedure devised by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), we performed safety evaluations on five acetal flavouring substances uniquely used in Japan: acetaldehyde 2,3-butanediol acetal, acetoin dimethyl acetal, hexanal dibutyl acetal, hexanal glyceryl acetal and 4-methyl-2-pentanone propyleneglycol acetal. As no genotoxicity study data were available in the literature, all five substances had no chemical structural alerts predicting genotoxicity. Using Cramer's classification, acetoin dimethyl acetal and hexanal dibutyl acetal were categorised as class I, and acetaldehyde 2,3-butanediol acetal, hexanal glyceryl acetal and 4-methyl-2-pentanone propyleneglycol acetal as class III. The estimated daily intakes for all five substances were within the range of 1.45-6.53 µg/person/day using the method of maximised survey-derived intake based on the annual production data in Japan from 2001, 2005, 2008 and 2010, and 156-720 µg/person/day using the single-portion exposure technique (SPET), based on the average use levels in standard portion sizes of flavoured foods. The daily intakes of the two class I substances were below the threshold of toxicological concern (TTC) - 1800 μg/person/day. The daily intakes of the three class III substances exceeded the TTC (90 μg/person/day). Two of these, acetaldehyde 2,3-butanediol acetal and hexanal glyceryl acetal, were expected to be metabolised into endogenous products after ingestion. For 4-methyl-2-pentanone propyleneglycol acetal, one of its metabolites was not expected to be metabolised into endogenous products. However, its daily intake level, based on the estimated intake calculated by the SPET method, was about 1/15 000th of the no observed effect level. It was thus concluded that all five substances raised no safety concerns when used for flavouring foods at the currently estimated intake levels. While no information on in vitro and in vivo toxicity for all five substances was available

Cayler cardiofacial syndrome and del 22q11: Part of the CATCH22 phenotype

DOE Office of Scientific and Technical Information (OSTI.GOV)

Giannotti, A.; Digilio, M.C.; Marino, B.

1994-11-15

The authors report evidence supporting the hypothesis that del(22)(q11) can be a pathogenetic mechanism for the association between hypoplasia of the depressor anguli oris muscle (DAOM) and conotruncal cardiac malformations. A series of over 180 patients was investigated with deletions of 22q11 with conotruncal defects. About 2/3 of these patients had isolated, nonfamilial cardiac defects. Hemizygosity was searched using the HD7k probe and densitometric analysis. In the patients with molecular evidence of del(22)(q11), hemizygosity was confirmed also using fluorescence in situ hybridization (FISH) with SC11.1 probe. No deletion was found in the parents of hemizygous patients. 16 refs.

Noguchi removes the FPEF MI in the JPM during Expedition 22

NASA Image and Video Library

2010-01-11

ISS022-E-020897 (11 Jan. 2010) --- Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, Expedition 22 flight engineer, works with Fluid Physics Experiment Facility/Marangoni Surface (FPEF MS) Core hardware in the Kibo laboratory of the International Space Station. The Marangoni convection experiment in the FPEF examines fluid tension flow in micro-G.

Noguchi removes the FPEF MI in the JPM during Expedition 22

NASA Image and Video Library

2010-01-11

ISS022-E-020894 (11 Jan. 2010) --- Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, Expedition 22 flight engineer, works with Fluid Physics Experiment Facility/Marangoni Surface (FPEF MS) Core hardware in the Kibo laboratory of the International Space Station. The Marangoni convection experiment in the FPEF examines fluid tension flow in micro-G.

Noguchi removes the FPEF MI in the JPM during Expedition 22

NASA Image and Video Library

2010-01-11

ISS022-E-020895 (11 Jan. 2010) --- Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, Expedition 22 flight engineer, works with Fluid Physics Experiment Facility/Marangoni Surface (FPEF MS) Core hardware in the Kibo laboratory of the International Space Station. The Marangoni convection experiment in the FPEF examines fluid tension flow in micro-G.

37 CFR 2.23 - Additional requirements for TEAS Plus application.

Code of Federal Regulations, 2011 CFR

2011-07-01

... TEAS Plus application. 2.23 Section 2.23 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND... § 2.23 Additional requirements for TEAS Plus application. (a) In addition to the filing requirements under § 2.22(a), the applicant must: (1) File the following communications through TEAS: (i) Responses...

37 CFR 2.23 - Additional requirements for TEAS Plus application.

Code of Federal Regulations, 2010 CFR

2010-07-01

... TEAS Plus application. 2.23 Section 2.23 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND... § 2.23 Additional requirements for TEAS Plus application. (a) In addition to the filing requirements under § 2.22(a), the applicant must: (1) File the following communications through TEAS: (i) Responses...

21 CFR 186.1555 - Japan wax.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Japan wax. 186.1555 Section 186.1555 Food and Drugs... Substances Affirmed as GRAS § 186.1555 Japan wax. (a) Japan wax (CAS Reg. No. 8001-39-6), also known as Japan... fruits of the oriental sumac, Rhus succedanea (Japan, Taiwan, and Indo-China), R. vernicifera (Japan...

Pressure deflected: Japan and the 1973 Arab oil embargo

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burridge, J.M.

1988-01-01

Japanese policy toward the Arab states for the five years before the embargo are compared with the five years that followed. Significant events from October 1973 through the February 1974 Washington Conference are described on a virtually daily basis. The study concludes that the late 1973 oil-supply reduction did not result in significantly greater Japanese political support or economic assistance in the 1974-1978 period. Japan did not even carry the only specific commitment in the November 22 statement - that it would reconsider relations with Israel if that country didn't withdraw from the occupied Arab territories. Many factors contributed tomore » this failure - American counter-pressure, Arab disunity, and a worldwide drop in oil demand. In terms of political demands, neither OAPEC nor any individual Arab state ever articulated any specific actions Japan was to take. Finally, the supply of oil was rapidly depoliticized after 1974.« less

21 CFR 1304.23 - Records for chemical analysts.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Records for chemical analysts. 1304.23 Section... REGISTRANTS Continuing Records § 1304.23 Records for chemical analysts. (a) Each person registered or authorized (by § 1301.22(b) of this chapter) to conduct chemical analysis with controlled substances shall...

21 CFR 1304.23 - Records for chemical analysts.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Records for chemical analysts. 1304.23 Section... REGISTRANTS Continuing Records § 1304.23 Records for chemical analysts. (a) Each person registered or authorized (by § 1301.22(b) of this chapter) to conduct chemical analysis with controlled substances shall...

21 CFR 1304.23 - Records for chemical analysts.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 9 2012-04-01 2012-04-01 false Records for chemical analysts. 1304.23 Section... REGISTRANTS Continuing Records § 1304.23 Records for chemical analysts. (a) Each person registered or authorized (by § 1301.22(b) of this chapter) to conduct chemical analysis with controlled substances shall...

21 CFR 1304.23 - Records for chemical analysts.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 9 2014-04-01 2014-04-01 false Records for chemical analysts. 1304.23 Section... REGISTRANTS Continuing Records § 1304.23 Records for chemical analysts. (a) Each person registered or authorized (by § 1301.22(b) of this chapter) to conduct chemical analysis with controlled substances shall...

21 CFR 1304.23 - Records for chemical analysts.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 9 2013-04-01 2013-04-01 false Records for chemical analysts. 1304.23 Section 1304.23 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE RECORDS AND REPORTS OF... authorized (by § 1301.22(b) of this chapter) to conduct chemical analysis with controlled substances shall...

Academic Libraries in Japan

ERIC Educational Resources Information Center

Cullen, Rowena; Nagata, Haruki

2008-01-01

Academic libraries in Japan are well resourced by international standards, and support Japan's internationally recognized research capability well, but there are also ways in which they reflect Japan's strong bureaucratic culture. Recent changes to the status of national university libraries have seen a new interest in customer service, and…

Study of the 20,22Ne+20,22Ne and 10,12,13,14,15C+12C Fusion Reactions with MUSIC

NASA Astrophysics Data System (ADS)

Avila, M. L.; Rehm, K. E.; Almaraz-Calderon, S.; Carnelli, P. F. F.; DiGiovine, B.; Esbensen, H.; Hoffman, C. R.; Jiang, C. L.; Kay, B. P.; Lai, J.; Nusair, O.; Pardo, R. C.; Santiago-Gonzalez, D.; Talwar, R.; Ugalde, C.

2016-05-01

A highly efficient MUlti-Sampling Ionization Chamber (MUSIC) detector has been developed for measurements of fusion reactions. A study of fusion cross sections in the 10,12,13,14,15C+12C and 20,22Ne+20,22Ne systems has been performed at ATLAS. Experimental results and comparison with theoretical predictions are presented. Furthermore, results of direct measurements of the 17O(α, n)20Ne, 23Ne(α, p)26Mg and 23Ne(α, n)26Al reactions will be discussed.

Japan's funding supremo

NASA Astrophysics Data System (ADS)

Durrani, Matin

2018-02-01

Yasuhiro Iye, a condensed-matter physicist who is executive director of the Japan Society for the Promotion of Science, talks to Matin Durrani about the pressures and challenges facing Japan's biggest funding agency

Database and Related Activities in Japan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murakami, Izumi; Kato, Daiji; Kato, Masatoshi

2011-05-11

We have constructed and made available atomic and molecular (AM) numerical databases on collision processes such as electron-impact excitation and ionization, recombination and charge transfer of atoms and molecules relevant for plasma physics, fusion research, astrophysics, applied-science plasma, and other related areas. The retrievable data is freely accessible via the internet. We also work on atomic data evaluation and constructing collisional-radiative models for spectroscopic plasma diagnostics. Recently we have worked on Fe ions and W ions theoretically and experimentally. The atomic data and collisional-radiative models for these ions are examined and applied to laboratory plasmas. A visible M1 transition ofmore » W{sup 26+} ion is identified at 389.41 nm by EBIT experiments and theoretical calculations. We have small non-retrievable databases in addition to our main database. Recently we evaluated photo-absorption cross sections for 9 atoms and 23 molecules and we present them as a new database. We established a new association ''Forum of Atomic and Molecular Data and Their Applications'' to exchange information among AM data producers, data providers and data users in Japan and we hope this will help to encourage AM data activities in Japan.« less

The Japan Conference on English for Specific Purposes Proceedings (Aizuwakamatsu City, Fukushima, November 8, 1997).

ERIC Educational Resources Information Center

Orr, Thomas, Ed.

The 13 papers archived here represent a sampling of the 23 presentations approved for the Japan Conference on English for Specific Purposes (ESP): "An Overview of ESP in the 1990s" (Tony Dudley-Evans); "'Easifying' ESP Texts for EFL Science Majors" (Judy Noguchi); "From Non-Communicative Exercises to Technical Writing:…

Comparison of Total Solar Irradiance with NASA/NSO Spectromagnetograph Data in Solar Cycles 22 and 23

NASA Technical Reports Server (NTRS)

Jones, Harrison P.; Branston, Detrick D.; Jones, Patricia B.; Popescu, Miruna D.

2002-01-01

An earlier study compared NASA/NSO Spectromagnetograph (SPM) data with spacecraft measurements of total solar irradiance (TSI) variations over a 1.5 year period in the declining phase of solar cycle 22. This paper extends the analysis to an eight-year period which also spans the rising and early maximum phases of cycle 23. The conclusions of the earlier work appear to be robust: three factors (sunspots, strong unipolar regions, and strong mixed polarity regions) describe most of the variation in the SPM record, but only the first two are associated with TSI. Additionally, the residuals of a linear multiple regression of TSI against SPM observations over the entire eight-year period show an unexplained, increasing, linear time variation with a rate of about 0.05 W m(exp -2) per year. Separate regressions for the periods before and after 1996 January 01 show no unexplained trends but differ substantially in regression parameters. This behavior may reflect a solar source of TSI variations beyond sunspots and faculae but more plausibly results from uncompensated non-solar effects in one or both of the TSI and SPM data sets.

1. West portal of Tunnel 23, contextual view to the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. West portal of Tunnel 23, contextual view to the west-northwest, 380mm lens. Tunnel 22 pierces the toe of Lookout Point. Note that the tracks have been realigned toward the Willamette River to bypass Tunnel 23. - Southern Pacific Railroad Natron Cutoff, Tunnel 23, Milepost 584.5, Westfir, Lane County, OR

Considerations Taken in Developing the Frequency Assignment Guidelines for Communications in the Mars Region Provided in SFCG Recommendation 22-1, (SFCG Action Item No. 23/10)

NASA Technical Reports Server (NTRS)

Wang, Charles C.; Peng, Ted; Sue, Miles K.

2004-01-01

In the 23'd Annual SFCG meeting in San Diego, CA, the SFCG created SFCG Action Item No. 23/10 to provide a readable summary of the work done by the Mars Interim Working Group (MIWG). The SFCG created the MIWG to develop a frequency plan for future Mars missions. The working group has produced a number of documents resulting in a recommendation, SFCG Rec 22-1 [1], titled Frequency Assignment Guidelines for Communications in Mars Region, including a frequency plan for the Mars Region. This document is prepared in response to the SFCG Action Item to provide an overview of the considerations taken when selecting the frequencies and to point out where detailed information of the considerations can be found.

Coronal Field Opens at Lower Height During the Solar Cycles 22 and 23 Minimum Periods: IMF Comparison Suggests the Source Surface Should Be Lowered (Postprint)

DTIC Science & Technology

2012-03-01

understood simply from differences in the areas of the coronal holes , as opposed to differences in the surface fields within them. In this study, we...invoke smaller source surface radii in the potential-field source-surface (PFSS) model to construct a consistent picture of the observed coronal holes ...that the values of ≈1.9 R and ≈1.8 R for the cycles 22 and 23 minimum periods, respectively, produce the best results. The larger coronal holes

Japan: Shikoku Island

Atmospheric Science Data Center

2016-08-24

... and island stations in the waters surrounding Japan and Korea. They characterized meteorological conditions, measured the atmospheric ... flew overhead. These MISR images, centered just north of Shikoku Island in southwest Japan, were acquired on April 13, 2001 ...

Mechanism of improved maintenance of 2,3-diphosphoglycerate in stored blood by the xanthone compound 2-(2-hydroxyethoxy)-6-(1-H-tetrazole-5-yl)xanthen-9-one (BW A440C).

PubMed

Beutler, E; Forman, L; West, C; Gelbart, T

1988-03-15

The effect of the xanthone derivative 2-(2-hydroxyethoxy)-6-(1-H-tetrazole-5-yl)xanthen-9-one (BW A440C) on red cells was studied. When added to stored red cells at a concentration of 6 mM, greatly improved preservation of 2,3-diphosphoglycerate (2,3-DPG) was observed. There was no effect on internal pH of the erythrocyte. At a concentration 0.500 mM, many red cell enzyme activities were inhibited completely. At a 0.500 mM concentration, however, inhibition of pyruvate kinase and diphosphoglycerate phosphatase was most striking. Inhibition of either of these enzymes could result in elevation of 2,3-DPG levels. BW A440C in concentrations which elevated 2,3-DPG levels in humans caused a decrease in 2,3-DPG levels in rabbits and markedly impaired the viability of 21-day stored rabbit erythrocytes.

22 CFR 23.5 - Claims for settlement by Department of State or General Accounting Office.

Code of Federal Regulations, 2010 CFR

2010-04-01

... General Accounting Office. 23.5 Section 23.5 Foreign Relations DEPARTMENT OF STATE FEES AND FUNDS FINANCE AND ACCOUNTING § 23.5 Claims for settlement by Department of State or General Accounting Office. Claims for settlement by the Department of State or by the General Accounting Office shall be submitted...

Physics in Japan

NASA Astrophysics Data System (ADS)

Khan, Sameen Ahmed

2018-04-01

I read your Japan special report with a keen interest. My first visit to Japan was in March 1994 to attend the JSPS-KEK International Spring School: High Energy Ion Beams – Novel Beam Techniques and their Applications.

19 CFR 102.23 - Origin and Manufacturer Identification

Code of Federal Regulations, 2010 CFR

2010-04-01

...; DEPARTMENT OF THE TREASURY RULES OF ORIGIN Rules of Origin § 102.23 Origin and Manufacturer Identification (a... 19 Customs Duties 1 2010-04-01 2010-04-01 false Origin and Manufacturer Identification 102.23... address of the entity performing the origin-conferring operations pursuant to § 102.21 or § 102.22, as...

Japan's aging economics.

PubMed

Ezrati, M

1997-01-01

"Japan's population is aging faster than that of any other country in the world. The unprecedented increase in retirees relative to the size of Japan's work force will force radical change if the nation is to avoid a fiscal crisis, or worse. These seemingly innocent demographic changes will force Japan to shrink its famously high savings rate, reverse its proud trade surplus, send more industry overseas, liberalize its tightly controlled markets, and take on a more active, high-profile foreign policy. Ultimately, these changes will shift the balance of power in East Asia." excerpt

Possible Food Sources of Macrozoobenthos in the Manko Mangrove Ecosystem, Okinawa (Japan): A Stable Isotope Analysis Approach

PubMed Central

Wardiatno, Yusli; Mardiansyah; Prartono, Tri; Tsuchiya, Makoto

2015-01-01

Identifying potential food sources in mangrove ecosystems is complex because of the multifarious inputs from both land and sea. This study, which was conducted in the Manko mangrove ecosystem of Okinawa, Japan, determined the composition of the stable isotopes δ13C and δ15N in primary producers and macrozoobenthos to estimate the potential food sources assimilated and to elucidate the target trophic levels of the macrozoobenthos. We measured the two stable isotope signatures of three gastropods (Cerithidea sp., Cassidula mustelina, Peronia verruculata), two crabs (Grapsidae sp., Uca sp.), mangrove tree (Kandelia candel) leaves, and sediment from the mangrove ecosystem. The respective carbon and nitrogen isotope signature results were as follows: −22.4‰ and 8.6‰ for Cerithidea sp., −25.06‰ and 8‰ for C. mustelina, −22.58‰ and 8‰ for P. verruculata, −24.3‰ and 10.6‰ for unidentified Grapsidae, −21.87 ‰ and 11.5 ‰ for Uca sp., −29.81‰ and 11‰ for K. candel, and −24.23‰ and 7.2‰ for the sediment. The stable isotope assimilation signatures of the macrozoobenthos indicated sediment as their food source. Considering the trophic levels, the stable isotope values may also indicate that the five macrozoobenthos species were secondary or higher consumers. PMID:26019747

21 CFR 186.1555 - Japan wax.

Code of Federal Regulations, 2013 CFR

2013-04-01

... fruits of the oriental sumac, Rhus succedanea (Japan, Taiwan, and Indo-China), R. vernicifera (Japan), and R. trichocarpa (China, Indo-China, India, and Japan). Japan wax is soluble in hot alcohol, benzene...

21 CFR 186.1555 - Japan wax.

Code of Federal Regulations, 2012 CFR

2012-04-01

... fruits of the oriental sumac, Rhus succedanea (Japan, Taiwan, and Indo-China), R. vernicifera (Japan), and R. trichocarpa (China, Indo-China, India, and Japan). Japan wax is soluble in hot alcohol, benzene...

21 CFR 186.1555 - Japan wax.

Code of Federal Regulations, 2011 CFR

2011-04-01

... fruits of the oriental sumac, Rhus succedanea (Japan, Taiwan, and Indo-China), R. vernicifera (Japan), and R. trichocarpa (China, Indo-China, India, and Japan). Japan wax is soluble in hot alcohol, benzene...

Barbarian medicine in feudal Japan.

PubMed

Fodstad, Harald; Hariz, Marwan I; Hirabayashi, Hidehiro; Ohye, Chihiro

2002-10-01

THE FIRST EUROPEANS to discover Japan were Portuguese traders who arrived in 1542. Fifteen years later, the Portuguese Jesuit priest and surgeon Luis De Almeida (1525-1583) founded the first Western hospital in Japan, for the care of lepers, syphilitics, and orphans. Because the hospital had a negative influence on the spread of Christianity, the Jesuits closed it in 1586. During the Tokugawa Shogunate (1600-1868), when Japan was secluded from the rest of the world, the only foreign physicians allowed to enter Japan were those employed by the Dutch factory at Dejima in Nagasaki. Only four of those physicians left behind seeds for the foundation of Western medicine in Japan, namely Caspar Schambergen, who founded a Japanese school of surgery in 1650; Engelbert Kämpfer, who visited Japan in 1691 to 1692; Carl Peter Thunberg, who botanically explored Japan in 1775 to 1776; and Philipp Franz Balthasar von Siebold, who practiced medicine in Nagasaki in 1823 to 1829 and 1859 to 1861. On the whole, Western medicine and surgery never established a real foothold in Japan until the fall of the shogunate and the restoration of the emperor in 1868.

PREFACE: International Conference on High Pressure Science and Technology, Joint AIRAPT-22 & HPCJ-50

NASA Astrophysics Data System (ADS)

Viña, Luis; Tejedor, Carlos; Calleja, José M.

2010-01-01

The International Joint AIRAPT-22 & HPCJ-50 Conference was held in Odaiba, Tokyo, on 26-31 July 2009. About 480 scientists from 24 countries attended the conference and 464 papers, including 3 plenary lectures, 39 invited talks, and 156 oral presentations, were presented. It is my great pleasure to present this proceedings volume, which is based on the high quality scientific works presented at the conference. The International AIRAPT conference has been held every two years in various countries around the world since 1965, while High Pressure Conference of Japan (HPCJ) has been held annually since 1959 in various Japanese cities. Pressure is a fundamental parameter to control the property of matter. As a result, both AIRAPT and HPCJ have become highly multidisciplinary, and cover Physics, Chemistry, Materials Science, Earth and Planetary Sciences, Biosciences, Food Science, and Technology. Although each discipline has a unique target, they all have high-pressure research in common. This proceedings volume includes about 200 papers of state-of-the-art studies from numerous fields. I hope this proceedings volume provides excellent pieces of information in various fields to further advance high-pressure research. Conference logo Takehiko Yagi Conference Chairman Institute for Solid State Physics The University of Tokyo 7 December 2009 Conference photograph Participants at the conference venue, Tokyo International Exchange Center, Odaiba, Tokyo, Japan. Editor in Chief TAKEMURA Kenichi National Institute for Materials Science, Japan Editorial board Tadashi KONDO Osaka University, Japan Hitoshi MATSUKI The University of Tokushima, Japan Nobuyuki MATUBAYASI Kyoto University, Japan Yoshihisa MORI Okayama University of Science, Japan Osamu OHTAKA Osaka University, Japan Chihiro SEKINE Muroran Institute of Technology, Japan

22 CFR 124.11 - Congressional certification pursuant to Section 36(d) of the Arms Export Control Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... the certification required by 22 U.S.C. 2776(d)(1) involving the North Atlantic Treaty Organization, any member country of that Organization, or Australia, Japan, New Zealand, or South Korea or at least...

22 CFR 124.11 - Congressional certification pursuant to Section 36(d) of the Arms Export Control Act.

Code of Federal Regulations, 2011 CFR

2011-04-01

... the certification required by 22 U.S.C. 2776(d)(1) involving the North Atlantic Treaty Organization, any member country of that Organization, or Australia, Japan, New Zealand, or South Korea or at least...

Polar Chromospheric Signatures of the Subdued Cycle 23/24 Solar Minimum

NASA Technical Reports Server (NTRS)

Gopalswamy, N.; Yashiro, S.; Makela, P.; Shibasaki, K.; Hathaway, D.

2010-01-01

Coronal holes appear brighter than the quiet Sun in microwave images, with a brightness enhancement of 500 to 2000 K. The brightness enhancement corresponds to the upper chromosphere, where the plasma temperature is about 10000 K. We constructed a microwave butterfly diagram using the synoptic images obtained by the Nobeyama radioheliograph (NoRH) showing the evolution of the polar and low latitude brightness temperature. While the polar brightness reveals the chromospheric conditions, the low latitude brightness is attributed to active regions in the corona. When we compared the microwave butterfly diagram with the magnetic butterfly diagram, we found a good correlation between the microwave brightness enhancement and the polar field strength. The microwave butterfly diagram covers part of solar cycle 22, whole of cycle 23, and part of cycle 24, thus enabling comparison between the cycle 23/24 and cycle 22/23 minima. The microwave brightness during the cycle 23/24 minimum was found to be lower than that during the cycle 22/23 minimum by approximately 250 K. The reduced brightness temperature is consistent with the reduced polar field strength during the cycle 23/24 minimum seen in the magnetic butterfly diagram. We suggest that the microwave brightness at the solar poles is a good indicator of the speed of the solar wind sampled by Ulysses at high latitudes.

Lactobacillus delivery of bioactive interleukin-22.

PubMed

Lin, Yin; Krogh-Andersen, Kasper; Hammarström, Lennart; Marcotte, Harold

2017-08-23

Interleukin-22 (IL-22) plays a prominent role in epithelial regeneration and dampening of chronic inflammatory responses by protecting intestinal stem cells from immune-mediated tissue damage. IL-22 has a considerable therapeutic potential in graft-versus-host disease (GVHD), which is a frequent and challenging complication following allogeneic stem cell transplantation. The aim of our study was to engineer Lactobacillus for delivery of IL-22 directly to the intestinal mucosa as a new therapeutic strategy for GVHD. The secretion and surface anchoring of mouse IL-22 by Lactobacillus paracasei BL23 was demonstrated by Western blot and flow cytometry. Both secreted and anchored mouse IL-22 produced by Lactobacillus was biologically active, as determined by its ability to induce IL-10 secretion in the Colo 205 human colon cancer cell line. We have demonstrated the secretion and surface anchoring of bioactive IL-22 by Lactobacillus. Our results suggest that IL-22 expressing lactobacilli may potentially be a useful mucosal therapeutic agent for the treatment of GVHD, provided that chromosomal integration of the IL-22 expression cassettes can be achieved.

Synthesis of the (N2)3- radical from Y2+ and its protonolysis reactivity to form (N2H2)2- via the Y[N(SiMe3)2]3/KC8 reduction system.

PubMed

Fang, Ming; Lee, David S; Ziller, Joseph W; Doedens, Robert J; Bates, Jefferson E; Furche, Filipp; Evans, William J

2011-03-23

Examination of the Y[N(SiMe(3))(2)](3)/KC(8) reduction system that allowed isolation of the (N(2))(3-) radical has led to the first evidence of Y(2+) in solution. The deep-blue solutions obtained from Y[N(SiMe(3))(2)](3) and KC(8) in THF at -35 °C under argon have EPR spectra containing a doublet at g(iso) = 1.976 with a 110 G hyperfine coupling constant. The solutions react with N(2) to generate (N(2))(2-) and (N(2))(3-) complexes {[(Me(3)Si)(2)N](2)(THF)Y}(2)(μ-η(2):η(2)-N(2)) (1) and {[(Me(3)Si)(2)N](2)(THF)Y}(2)(μ-η(2):η(2)-N(2))[K(THF)(6)] (2), respectively, and demonstrate that the Y[N(SiMe(3))(2)](3)/KC(8) reaction can proceed through an Y(2+) intermediate. The reactivity of (N(2))(3-) radical with proton sources was probed for the first time for comparison with the (N(2))(2-) and (N(2))(4-) chemistry. Complex 2 reacts with [Et(3)NH][BPh(4)] to form {[(Me(3)Si)(2)N](2)(THF)Y}(2)(μ-N(2)H(2)), the first lanthanide (N(2)H(2))(2-) complex derived from dinitrogen, as well as 1 as a byproduct, consistent with radical disproportionation reactivity.

Central part of Pier 22, showing the southeast side of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Central part of Pier 22, showing the southeast side of the Shore Power Supply Electric Distribution Center (Building 734) - Mare Island Naval Shipyard, Finger Piers 22 & 23, Railroad Avenue near Eighteenth Street, Vallejo, Solano County, CA

No immediate relief for large mining tire shortage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fiscor, S.

2006-05-15

Inventories are low and they will not get better anytime soon, but mine operators do have a few options. The three main manufacturers supplying tires to the US mining industry, Bridgestone Firestone Off Road Tire Company, Goodyear and Michelin are struggling to keep up with demand, but are unlikely to restore inventories to manageable levels by 2009. Meanwhile Yokohama and Global Tyres have stepped in to help. The article reports plans for expansions to plant in Japan. In the meantime, mine operators need to plan accordingly and pay increased attention to tire maintenance. The larger the tyre, the less availablemore » it is. 3 photos.« less

Japan Report

DTIC Science & Technology

1985-03-18

increased profitability, productivity and more effective management ." Members of the British side also called for an increase in Japan’s defense...copyright transfer, or rental permission is called technology trade. According to the Statistic Bureau of the Management and Coordina- tion Agency...1- 8.8 -Swizerland 6.3 5.6 Others 13.1 Source: Statistics Bureau of the Management and Coordination Agency China. 66.2% of Japan’s imported

23 CFR 1200.20 - General.

Code of Federal Regulations, 2010 CFR

2010-04-01

... cost principles govern the implementation and management of State highway safety programs carried out under 23 U.S.C. 402. Cost principles include those referenced in 49 CFR 18.22 and those set forth in... Implementation and Management of the Highway Safety Program § 1200.20 General. Except as otherwise provided in...

50 CFR 23.22 - What are the requirements for in-transit shipments?

Code of Federal Regulations, 2010 CFR

2010-10-01

... the presence of valid documentation. See § 23.50 for in-transit shipment of sample collections covered... migratory bird (part 10 of this subchapter), injurious wildlife (part 16 of this subchapter), endangered or...

Breast cancer information communicated on a public online platform: an analysis of 'Yahoo! Answer Japan'.

PubMed

Ohigashi, An; Ahmed, Salim; Afzal, Arfan R; Shigeta, Naoko; Tam-Tham, Helen; Kanda, Hideyuki; Ishikawa, Yoshihiro; Turin, Tanvir C

2017-06-01

INTRODUCTION Japan is a developed country with high use of Internet and online platforms for health information. 'Yahoo! Answer Japan' is the most commonly used question-and-answer service in Japan. AIM To explore the information users seek regarding breast cancer from the 'Yahoo! Answer Japan' web portal. METHODS The 'Yahoo! Answer Japan' portal was searched for the key word 'breast cancer' and all questions searched for the period of 1 January to 31 December 2014 were obtained. The selected questions related to human breast cancer and were not advertisements or promotional material. The questions were categorized using a coding schema. High and low access of the questions were defined by the number of view-counts. RESULTS Among the 2392 selected questions, six major categories were identified; (1) suspected breast cancer, (2) breast cancer screening, (3) treatment of breast cancer, (4) life with breast cancer, (5) prevention of breast cancer and (6) others. The highest number of questions were treatment related (28.8%) followed by suspected breast cancer-related questions (23.4%) and screening-related questions (20%). Statistical analysis revealed that the treatment-related questions were more likely to be highly accessed. CONCLUSION Content analysis of Internet question-answer communities is important, as questions posted on these sites would serve as a rich source of direct reflection regarding the health-related information needs of the general population.

Youth Corrections in Japan: Family-Like Setting for Delinquents with the Experiences of Child Maltreatment

ERIC Educational Resources Information Center

Matsuura, Naomi

2011-01-01

It is very well known that Japan has an extremely low rate of crime compared with other developed countries. Due to fewer serious incidents such as murder, rape, and arson, Japanese society is generally peaceful and orderly. For instance, although there are 23 million juveniles who are younger than 20 years old, only 39 homicides were committed in…

Industrial lasers in Japan

NASA Astrophysics Data System (ADS)

Karube, Norio

1991-03-01

I am to report on some aspects of industrial lasers in Japan. Mostly centering on the market. In Japan, the history of laser developnent is rather profound. And long. Ever since the first invention of the laser in this country in 1960. This is partly because of the fact that in Japan the spectroscopic studies of the ruby was very popular in the late 1950's. Ever since niost of the work has been done in the research laboratories of the industry, not in the universities or not in the governmental laboratories. And since that time our first activity was mainly centering on the basic research, but after that time we have the evolution of the technology. One of the features in Japan is that the activity of developement and research of laser technology from the very basic phase up to the present commercialization has been done by the same group of people, including ine. We had a national project which ended about six years ago which was sponsored by MITI. MITI is Ministry of International Trade and Industry in Japan. And because of this national project, the effect of this project had a very enlightening effect in Japan. And after that our Japanese laser market became very flourishing.

Central part of Pier 22, southwest part, showing the northwest ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Central part of Pier 22, southwest part, showing the northwest side of the Shore Power Supply Electric Distribution Center (Building 734) - Mare Island Naval Shipyard, Finger Piers 22 & 23, Railroad Avenue near Eighteenth Street, Vallejo, Solano County, CA

Th17 and Th22 cells in psoriatic arthritis and psoriasis

PubMed Central

2013-01-01

Introduction The aim of this study was to characterize interleukin 17 (IL-17) and interleukin 22 (IL-22) producing cells in peripheral blood (PB), skin, synovial fluid (SF) and synovial tissue (ST) in patients with psoriasis (Ps) and psoriatic arthritis (PsA). Methods Flow cytometry was used to enumerate cells making IL-22 and IL-17, in skin and/or SF and PB from 11 patients with Ps and 12 patients with PsA; skin and PB of 15 healthy controls and SF from rheumatoid arthritis (RA) patients were used as controls. Expression of the interleukin 23 receptor (IL-23R) and chemokine receptors CCR4 and CCR6 was examined. Secretion of IL-17 and IL-22 was measured by ELISA. ST was analysed by immunohistochemical staining of IL-17 and IL-22. Results Increased frequencies of IL-17+ and IL-22+ CD4+ T cells were seen in PB of patients with PsA and Ps. IL-17 secretion was significantly elevated in both PsA and Ps, whilst IL-22 secretion was higher in PsA compared to Ps and healthy controls. A higher proportion of the CD4+ cells making IL-17 or IL-22 expressed IL-23R and frequencies of IL-17+, CCR6+ and CCR4+ T cells were elevated in patients with Ps and those with PsA. In patients with PsA, CCR6+ and IL-23R + T cells numbers were elevated in SF compared to PB. Increased frequencies of IL-17+ and IL-22+ CD4+ T cells were demonstrated in Ps skin lesions. In contrast, whilst elevated frequencies of CD4+ IL-17+ cells were seen in PsA SF compared to PB, frequencies of CD4+ IL-22+ T cells were lower. Whereas IL-17 expression was equivalent in PsA, osteoarthritis (OA) and RA ST, IL-22 expression was higher in RA than either OA or PsA ST, in which IL-22 was strikingly absent. Conclusions Elevated frequencies of IL-17 and IL-22 producing CD4+ T cells were a feature of both Ps and PsA. However their differing distribution at disease sites, including lower frequencies of IL-22+ CD4+ T cells in SF compared to skin and PB, and lack of IL-22 expression in ST suggests that Th17 and Th22 cells

21 CFR 520.1846 - Polyoxyethylene (23) lauryl ether blocks.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Polyoxyethylene (23) lauryl ether blocks. 520.1846... Polyoxyethylene (23) lauryl ether blocks. (a) Specifications. Each molasses-based block contains 2.2 percent... (1 pound of block per 500 kilogram (1,100 pound) animal per day). (2) Indications for use. For...

Universals and cultural variations in 22 emotional expressions across five cultures.

PubMed

Cordaro, Daniel T; Sun, Rui; Keltner, Dacher; Kamble, Shanmukh; Huddar, Niranjan; McNeil, Galen

2018-02-01

We collected and Facial Action Coding System (FACS) coded over 2,600 free-response facial and body displays of 22 emotions in China, India, Japan, Korea, and the United States to test 5 hypotheses concerning universals and cultural variants in emotional expression. New techniques enabled us to identify cross-cultural core patterns of expressive behaviors for each of the 22 emotions. We also documented systematic cultural variations of expressive behaviors within each culture that were shaped by the cultural resemblance in values, and identified a gradient of universality for the 22 emotions. Our discussion focused on the science of new expressions and how the evidence from this investigation identifies the extent to which emotional displays vary across cultures. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

A pilot study of tele-anaesthesia by virtual private network between an island hospital and a mainland hospital in Japan.

PubMed

Miyashita, Tetsuya; Mizuno, Yusuke; Sugawara, Yo; Nagamine, Yusuka; Koyama, Yukihide; Miyazaki, Tomoyuki; Uchimoto, Kazuhiro; Iketani, Yasuhiro; Tojo, Kentaro; Goto, Takahisa

2015-03-01

We studied the use of tele-anaesthesia between Sado General Hospital (SGH) located on Sado Island and Yokohama City University Hospital (YCUH) located in mainland Japan. The two sites were connected via a virtual private network (VPN). We investigated the relationship between the bandwidth of the VPN and both the frame rate and the delay time of the tele-anaesthesia monitoring system. The tool used for communication between the two hospitals was free videoconferencing software (FaceTime), which can be used over Wi-Fi connections. We also investigated the accuracy of the commands given during teleanaesthesia: any commands from the anaesthetist at the YCUH that were not carried out for any reason, were recorded in the anaesthetic records at the SGH. The original frame rate and data rate at the SGH were 5 fps and approximately 18 Mbit/s, respectively. The frame rate at the transmission speeds of 1, 5 and 20 Mbit/s was 0.6, 1.6 and 5.0 fps, respectively. The corresponding delay time was 12.2, 4.9 and 0.7 s. Twenty-five adult patients were enrolled in the study and tele-anaesthesia was performed. The total duration of anaesthesia was 37 hours. All 888 anaesthetic commands were completed. There were 7 FaceTime disconnections, which lasted for 10 min altogether. Because no commands needed to be given during the FaceTime disconnection, the telephone was not used. The anaesthesia assistance system might form part of the solution to medical resource shortages. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

17 CFR 23.23-23.40 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-04-01

... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false [Reserved] 23.23-23.40 Section 23.23-23.40 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION SWAP DEALERS AND MAJOR SWAP PARTICIPANTS Registration §§ 23.23-23.40 [Reserved] ...

17 CFR 23.23-23.40 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-04-01

... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false [Reserved] 23.23-23.40 Section 23.23-23.40 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION SWAP DEALERS AND MAJOR SWAP PARTICIPANTS Registration §§ 23.23-23.40 [Reserved] ...

17 CFR 23.23-23.40 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-04-01

... 17 Commodity and Securities Exchanges 1 2014-04-01 2014-04-01 false [Reserved] 23.23-23.40 Section 23.23-23.40 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION SWAP DEALERS AND MAJOR SWAP PARTICIPANTS Registration §§ 23.23-23.40 [Reserved] ...

View of north and west elevation of Building No. 23. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View of north and west elevation of Building No. 23. Parking Area No. 32 in foreground and Building No. 22 at right rear. Looking southwest - Easter Hill Village, Building No. 23, North side of South Twenty-sixth Street, east of Corto Square, Richmond, Contra Costa County, CA

Recent damaging earthquakes in Japan, 2003-2008

USGS Publications Warehouse

Kayen, Robert E

2008-01-01

During the last six years, from 2003-2008, Japan has been struck by three significant and damaging earthquakes: The most recent M6.6 Niigata Chuetsu Oki earthquake of July 16, 2007 off the coast of Kashiwazaki City, Japan; The M6.6 Niigata Chuetsu earthquake of October 23, 2004, located in Niigata Prefecture in the central Uonuma Hills; and the M8.0 Tokachi Oki Earthquake of September 26, 2003 effecting southeastern Hokkaido Prefecture. These earthquakes stand out among many in a very active period of seismicity in Japan. Within the upper 100 km of the crust during this period, Japan experienced 472 earthquakes of magnitude 6, or greater. Both Niigata events affected the south-central region of Tohoku Japan, and the Tokachi-Oki earthquake affected a broad region of the continental shelf and slope southeast of the Island of Hokkaido. This report is synthesized from the work of scores of Japanese and US researchers who led and participated in post-earthquake reconnaissance of these earthquakes: their noteworthy and valuable contributions are listed in an extended acknowledgements section at the end of the paper. During the Niigata Chuetsu Oki event of 2007, damage to the Kashiwazaki-Kariwa nuclear power plant, structures, infrastructure, and ground were primarily the product of two factors: (1) high intensity motions from this moderate-sized shallow event, and (2) soft, poor performing, or liquefiable soils in the coastal region of southwestern Niigata Prefecture. Structural and geotechnical damage along the slopes of dunes was ubiquitous in the Kashiwazaki-Kariwa region. The 2004 Niigata Chuetsu Earthquake was the most significant to affect Japan since the 1995 Kobe earthquake. Forty people were killed, almost 3,000 were injured, and many hundreds of landslides destroyed entire upland villages. Landslides were of all types; some dammed streams, temporarily creating lakes threatening to overtop their new embankments and cause flash floods and mudslides. The numerous

Women's Education, Learning and Empowerment. Proceedings of the International Forum on Intercultural Exchange (Saitama, Japan, November 20-23, 1996).

ERIC Educational Resources Information Center

National Women's Education Centre, Saitama (Japan).

This document in Japanese and English was prepared for the International Forum on Intercultural Exchange sponsored by the National Women's Education Centre in Japan to give participants the conference schedule and profiles of the presenters. Profiles are accompanied by comments from the presenters about their paper topics or the general theme of…

Japan Report.

DTIC Science & Technology

1987-02-03

of Keidanren’s U.S. Investment Mission, who is also vice chairman of the Industrial Bank of Japan; Mamoru Sakai, leader of the B Group of...Keidanren’s U.S. Investment Mission, who is also a director of the Japan Long-Term Credit Bank ; Masayoshi Tozaki, leader of the C Group of Keidanren’s U.S...Constitution. At the same time, Federal Reserve Bank Chairman Volcker has repeatedly stressed that maintaining the value of the dollar is essential. In

Japan: Teaching Units.

ERIC Educational Resources Information Center

Hadley, Marilyn, Ed.; And Others

This teaching guide was developed by undergraduate elementary education students as part of the requirements for a social studies methods course. The guide presents nine teaching units about various aspects of Japan. The unit topics range from the broad to the specific, and reflect a variety of approaches for teaching about Japan in the public…

Japan's High Schools.

ERIC Educational Resources Information Center

Rohlen, Thomas P.

The author, an anthropologist, spent 14 months (1974-75) in the industrial port city of Kobe (Japan) observing a cross section of urban high schools, including Japan's most elite private school and a night vocational school plagued by absenteeism and delinquency. He reports on the character of the institutions and of the experience via…

40 CFR 148.23 - Review of exemptions granted pursuant to a petition.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Procedures § 148.23 Review of exemptions granted pursuant to a petition. (a) When considering whether to... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Review of exemptions granted pursuant to a petition. 148.23 Section 148.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY...

Survey of Stereotactic Body Radiation Therapy in Japan by the Japan 3-D Conformal External Beam Radiotherapy Group

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nagata, Yasushi; Hiraoka, Masahiro; Mizowaki, Takashi

2009-10-01

Purpose: To recognize the current status of stereotactic body radiotherapy (SBRT) in Japan, using a nationwide survey conducted by the Japan 3-D Conformal External Beam Radiotherapy Group. Methods and Materials: The questionnaire was sent by mail to 117 institutions. Ninety-four institutions (80%) responded by the end of November 2005. Fifty-three institutions indicated that they have already started SBRT, and 38 institutions had been reimbursed by insurance. Results: A total of 1111 patients with histologically confirmed lung cancer were treated. Among these patients, 637 had T1N0M0 and 272 had T2N0M0 lung cancer. Metastatic lung cancer was found in 702 and histologicallymore » unconfirmed lung tumor in 291 patients. Primary liver cancer was found in 207 and metastatic liver cancer in 76 patients. The most frequent schedule used for primary lung cancer was 48Gy in 4 fractions at 22 institutions (52%), followed by 50Gy in 5 fractions at 11 institutions (26%) and 60Gy in 8 fractions at 4 institutions (10%). The tendency was the same for metastatic lung cancer. The average number of personnel involved in SBRT was 1.8 radiation oncologists, including 1.1 certified radiation oncologists, 2.8 technologists, 0.7 nurses, and 0.6 certified quality assurance personnel and 0.3 physicists. The most frequent amount of time for treatment planning was 61-120min, for quality assurance was 50-60min, and for treatment was 30min. There were 14 (0.6% of all cases) reported Grade 5 complications: 11 cases of radiation pneumonitis, 2 cases of hemoptysis, and 1 case of radiation esophagitis. Conclusion: The current status of SBRT in Japan was surveyed.« less

Chromospheric Signatures of the Subdued Cycle 23/24 Solar Minimum in Microwaves

NASA Technical Reports Server (NTRS)

Yashiro, S.; Makela, P.; Shibasaki, K.; Hathaway, D.

2011-01-01

Coronal holes appear brighter than the quiet Sun in microwave images, with a brightness enhancement of 500 to 2000 K. The brightness enhancement corresponds to the upper chromosphere, where the plasma temperature is about 10000 K. We constructed a microwave butterfly diagram using the synoptic images obtained by the Nobeyama radio-heliograph (NoRH) showing the evolution of the polar and low latitude brightness temperature. While the polar brightness reveals the chromospheric conditions, the low latitude brightness is attributed to active regions in the corona. When we compared the microwave butterfly diagram with the magnetic butterfly diagram, we found a good correlation between the microwave brightness enhancement and the polar field strength. The microwave butterfly diagram covers part of solar cycle 22, whole of cycle 23, and part of cycle 24, thus enabling comparison between the cycle 23/24 and cycle 22/23 minima. The microwave brightness during the cycle 23/24 minimum was found to be lower than that during the cycle 22/23 minimum by approx.250 K. The reduced brightness temperature is consistent with the reduced polar field strength during the cycle 23/24 minimum seen in the magnetic butterfly diagram. We suggest that the microwave brightness at the solar poles is a good indicator of the speed of the solar wind sampled by Ulysses at high latitudes.

Microelectronics in Japan

NASA Astrophysics Data System (ADS)

Boulton, William R.

1995-02-01

The purpose of this JTEC study is to evaluate Japan's electronic manufacturing and packaging capabilities within the context of global economic competition. To carry out this study, the JTEC panel evaluated the framework of the Japanese consumer electronics industry and various technological and organizational factors that are likely to determine who will win and lose in the marketplace. This study begins with a brief overview of the electronics industry, especially as it operates in Japan today. Succeeding chapters examine the electronics infrastructure in Japan and take an in-depth look at the central issues of product development in order to identify those parameters that will determine future directions for electronic packaging technologies.

Microelectronics in Japan

NASA Technical Reports Server (NTRS)

Boulton, William R.

1995-01-01

The purpose of this JTEC study is to evaluate Japan's electronic manufacturing and packaging capabilities within the context of global economic competition. To carry out this study, the JTEC panel evaluated the framework of the Japanese consumer electronics industry and various technological and organizational factors that are likely to determine who will win and lose in the marketplace. This study begins with a brief overview of the electronics industry, especially as it operates in Japan today. Succeeding chapters examine the electronics infrastructure in Japan and take an in-depth look at the central issues of product development in order to identify those parameters that will determine future directions for electronic packaging technologies.

Globalization and Education in Japan

ERIC Educational Resources Information Center

Ohkura, Kentaro; Shibata, Masako

2009-01-01

In this paper, the authors contend that globalization in Japan is the gradual process in which Japan's positioning of "self" within international relations, which had formerly been dominated by the West, has changed. Accordingly, Japan's relationships with the West and the rest of the world, for example, Asia, have also been reviewed and…

PREFACE: 3rd International Workshop on "State of the Art in Nuclear Cluster Physics"

NASA Astrophysics Data System (ADS)

Yamada, Taiichi; Kanada-En'yo, Yoshiko

2014-12-01

The 3rd International Workshop on "State of the Art in Nuclear Cluster Physics"(SOTANCP3) was held at KGU Kannai Media Center, Kanto Gakuin University, Yokohama, Japan, from May 26 to 30, 2014. Yokohama is the second largest city in Japan, about 25 km southeast of Tokyo. The first workshop of the series was held in Strasbourg, France, in 2008 and the second one was in Brussels, Belgium, in 2010. The purpose of SOTANCP3 was to discuss the present status and future perspectives of the nuclear cluster physics. The following nine topics were selected in order to cover most of the scientific programme and highlight an area where new ideas have emerged over recent years: (1) Cluster structures and many-body correlations in stable and unstable nuclei (2) Clustering aspects of nuclear reactions and resonances (3) Alpha condensates and analogy with condensed matter approaches (4) Role of tensor force in cluster physics and ab initio approaches (5) Clustering in hypernuclei (6) Nuclear fission, superheavy nuclei, and cluster decay (7) Cluster physics and nuclear astrophysics (8) Clustering in nuclear matter and neutron stars (9) Clustering in hadron and atomic physics There were 122 participants, including 53 from 17 foreign countries. In addition to invited talks, we had many talks selected from contributed papers. There were plenary, parallel, and poster sessions. Poster contributions were also presented as four-minute talks in parallel sessions. This proceedings contains the papers presented in invited and selected talks together with those presented in poster sessions. We would like to express our gratitude to the members of the International Advisory Committee and those of the Organizing Committee for their efforts which made this workshop successful. In particular we would like to present our great thanks to Drs. Y. Funaki, W. Horiuchi, N. Itagaki, M. Kimura, T. Myo, and T. Yoshida. We would like also to thank the following organizations for their sponsors: RCNP

International Traffic in Arms Regulations (ITAR), (22 CFR 120-130)

DTIC Science & Technology

1996-06-01

Butadienenitrileoxide (BNO); (6) Catocene, N-butyl- ferrocene and other ferrocene derivatives; (7) 3-nitraza-l,5 pentane diisocyanate; (8) Bis(2,2...Tris-l-(2-methyl)aziridinyl phosphine oxide (MAPO), bis(2-methyl aziridinyl) 2-(2-hydroxypropanoxy) propylamino phosphine oxide (BOBBA 8), and...other MAPO derivatives; (22) Bis(2-methyl aziridinyl) methylamino phosphine oxide (methyl BAPO); (23) Organo-metallic coupling agents, specifi

Exploring the anomaly in the interaction cross section and matter radius of (23)O

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kanungo, R.; Uchida, M.; Perro, C.

New measurements of the interaction cross sections of {sup 22,23}O at 900A MeV performed at the GSI, Darmstadt are reported that address the unsolved puzzle of the large cross section previously observed for {sup 23}O. The matter radii for these oxygen isotopes extracted through a Glauber model analysis are in good agreement with the new predictions of the ab initio coupled-cluster theory reported here. They are consistent with a {sup 22}O + neutron description of {sup 23}O as well.

[Acute encephalopathy caused by cyanogenic fungi in 2004, and magic mushroom regulation in Japan].

PubMed

Gonmori, Kunio; Yokoyama, Kazumasa

2009-03-01

Two topics, related to mushroom poisoning of recent interest in Japan, have been presented. In autumn 2004, 59 cases of acute encephalopathy were reported across 9 prefectures in Japan (24 from Akita Prefecture with 8 deaths; age 48-93, average 70; female 14, male 10). Of 24 cases, 20 had kidney dysfunction. Four poisoned subjects showed no kidney trouble. Of the 24 poisoning cases, 23 people ate Pleurocybella porrigens, and one ate Grifola frondosa. The latter subject (female, late 40's) was receiving dialysis for more than 35 years. In August, she felt dizziness, headache and tinnitus. She visited hospital and asked to stay there. In the hospital she ate 5g of stewed G. frondosa and 10g of the same fungus boiled with chicken and taro on different days. Fourteen to 18 days after the eatings, she developed cramps and lost consciousness, and fell into a coma. Her cramp and coma continued for about 10 days almost until her death. Her symptoms caused by G. frondosa were similar to those observed for the above 23 cases of P. porrigens ingestion. Therefore, we concluded that encephalopathy experienced in Akita Prefecture caused by was the cyanogenic fungi such as P. porrigens , G. frondosa, Pleurotus eringii etc. Although the amounts of mushrooms eaten by poisoned subjects were not so clear, we estimated that the amounts of hydrogen cyanide (HCN) taken into human bodies exceeded the detoxication limit of HCN, resulting in HCN poisoning. However, it has not been proved that the encephalopathy is directly or indirectly caused by the HCN poisoning. Many typhoons came across Japan and landed 10 times in 2004, and mushroom size was larger than usual one, and HCN contents in fruit-bodies seemed to be increased especially in the late-stage of their growth. Thirteen species of magic mushrooms were prohibited by the law from 2002 in Japan. They include Copelandia (Panaeolus) cyanescens, Panaeolus papilionaceus, Panaeolus sphinctrinus, Panaeolus subbalteatus, Psilocybe argentipes

Looking northeast from shore along the length of Pier 22 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Looking northeast from shore along the length of Pier 22 with a view of rigging platforms and Shore Power Supply Electric Distribution Center (Building 734) in the distance - Mare Island Naval Shipyard, Finger Piers 22 & 23, Railroad Avenue near Eighteenth Street, Vallejo, Solano County, CA

20. MANUAL JACKING STATION UNIT 23 GORGE POWERHOUSE. JACKING FOR ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. MANUAL JACKING STATION UNIT 23 GORGE POWERHOUSE. JACKING FOR UNITS 23, 22, AND 21 HAS BEEN AUTOMATED FOR MANY YEARS BUT THE MANUAL JACKING STATIONS REMAIN IN PLACE AND FUNCTIONAL, 1989. - Skagit Power Development, Gorge Powerhouse, On Skagit River, 0.4 mile upstream from Newhalem, Newhalem, Whatcom County, WA

The role of IL 23 in the treatment of psoriasis.

PubMed

Puig, Lluís

2017-06-01

The IL-23/IL-17 axis is currently considered to be crucial in the pathogenesis of psoriasis. Human IL-23 is primarily produced by antigen-presenting cells and induces and maintains differentiation of Th17 cells and Th22 cells, a primary cellular source of proinflammatory cytokines such as IL-17 and IL-22, which mediate the epidermal hyperplasia, keratinocyte immune activation and tissue inflammation inherent in psoriasis. Agents that target the p40 subunit common to both IL-12 and IL-23 have shown robust clinical activity, but selectivity for IL-23p19 could offer advantages in efficacy and safety with respect to anti-p40 blockade. Areas covered: Relevant references regarding the role of the IL-23/IL-17 pathway in the pathogenesis of psoriasis/psoriatic arthritis and clinical trials with IL-23p40 and IL-23p19 blocking agents were obtained through a literature search in MEDLINE/Pubmed for articles published until November 2016. Moreover, ongoing registered clinical trials (RCTs) of moderate-to-severe psoriasis and psoriatic arthritis were searched through clinicaltrials.gov website, and a manual search was made for pertinent communications at the 2016 American Academy of Dermatology and European Academy of Dermatology and Venereology meetings. Expert commentary: There are potential advantages in selective blockade of the IL23-specific p19 subunit with respect to distal blockade of IL-17A or its receptor. Acting upstream in the IL-23/IL-17 cytokine pathway is likely to reduce the expression of multiple pro-inflammatory cytokines acting on keratinocytes -including IL-17F, IL-21 and IL-22-, in addition to IL-17A. On the other hand, safety data thus far suggest that these drugs might be devoid of some adverse effects of IL-17A blockade that seem to be class related, such as mucocutaneous Candida infections or triggering or worsening of inflammatory bowel disease. Specific IL-23p19 blockade with high-affinity monoclonal antibodies seems to be able to induce long

Free Resources for Teaching about Japan. Revised Edition.

ERIC Educational Resources Information Center

Wojtan, Linda S.