Sample records for yong man ro

  1. Exploring Global Perspectives: An Interview with Yong Zhao

    ERIC Educational Resources Information Center

    Henshon, Suzanna E.

    2017-01-01

    Yong Zhao is Foundations Distinguished Professor in the School of Education with an appointment in the School of Business at the University of Kansas. Prior to joining KU, he served as the Presidential Chair, Director of the Institute for Global and Online Education, and Associate Dean in the College of Education, University of Oregon, where he…

  2. Valores, Creencias Y Objectivos: Base del programa de la Escuela Experimental P.K. Yonge. (Values, Beliefs and Objectives: The Basis of Experimental Schools P.K. Yonge's Program.)

    ERIC Educational Resources Information Center

    Florida Univ., Gainesville. Coll. of Education.

    The values, beliefs, and objectives that form the core of the program at the Experimental School P.K. Yonge in the University of Florida are presented in this paper which is written in Spanish. This experimental school serves approximately 900 students from grades one through twelve. The function of the school is to conduct research to solve…

  3. Evaluation of RO modules for the SSP ETC/LSS.

    NASA Technical Reports Server (NTRS)

    Jasionowski, W. J.; Bambenek, R. A.

    1973-01-01

    During the past eight years the NASA Manned Spacecraft Center has supported the development of an Integrated Water and Waste Management System for use in the Space Station Prototype (SSP) Environmental Thermal Control/Life-Support System (ETC/LSS). This system includes the reverse osmosis (RO) process for recycling wash water and the compression distillation process for recovering useable water from urine, urinal flush water, humidity condensate, commode flush water and the wash water concentrated by RO. This paper summarizes the experimental work performed during the past four years to select the best commercially available RO module for this system and to also define which surfactants and germicides are most compatible with the selected module.

  4. [Research on medical works of Yuan dynasty quoted by Yong le da dian (The Great classic of Yongle reign)].

    PubMed

    Du, Yong

    2003-01-01

    The medical works quoted by Yong le da dian (The Great Classic of Yongle reign) are rather numerous, most of them were lost, and the lives of most of the authors were unknown. By careful investigation, the authors and their lives, circulation of these works, are still pursuable.

  5. Distribution and fate modeling of 4-nonylphenol, 4-t-octylphenol, and bisphenol A in the Yong River of China.

    PubMed

    Cheng, Jun-Rui; Wang, Kan; Yu, Jie; Yu, Zhen-Xun; Yu, Xu-Biao; Zhang, Zhao-Zhao

    2018-03-01

    In this study, the concentrations of 4-nonylphenol (4-NP), 4-tert-octylphenol (4-t-OP), and bisphenol A (BPA) in the water column of the Yong River were investigated and found to be in the range of 140-3948, 6-828, and 15-1415 ng L -1 , respectively. A fate and transport model coupled with the Water Quality Analysis Simulation Program (WASP) was developed. After model calibration and validation, the distributions of 4-NP, 4-t-OP, and BPA in the Yong River were modeled for the duration of 2015. The total contaminant loads from the upstream boundary, four tributaries and two wastewater treatment plants were determined to be 2318 kg yr -1 for 4-NP, 506 kg yr -1 for 4-t-OP, and 970 kg yr -1 for BPA. Both measured and modeled results reported higher concentrations of the selected contaminants near river confluences and at the outfalls of the wastewater treatment plants. Peak concentrations were found to always appear in months with relatively reduced precipitation. The influences of adsorption and degradation on the dissolved concentrations of the selected chemicals were also modeled. The combined effects of adsorption and degradation were found to reduce dissolved concentrations of 4-NP, 4-t-OP, and BPA by 17.9%, 30.7%, and 12.1%, respectively. Adsorption was shown to reduce 4-NP concentrations in the Yong River more than degradation. Conversely, adsorption and degradation caused almost equal reductions in the dissolved concentrations of 4-t-OP and degradation caused larger decreases than adsorption in the dissolved concentrations of BPA. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. A Study for the Restoration of Hong Dae-Yong Honsangui - Focusing on the structure and operating mechanism

    NASA Astrophysics Data System (ADS)

    Lee, Yong Sam; Kim, Sang Hyuk; Park, Je Hoon

    2013-09-01

    Honsangui (celestial globe) which is a water-hammering method astronomical clock is recorded in "Juhaesuyong" which is Volume VI of supplement from "Damheonseo", written by Hong Dae-Yong (1731~1783). We made out the conceptual design of Hong Dae-Yong's Honsangui through the study on its structure and working mechanism. Honsangui consist of three rings and two layers, the structure of rings which correspond to outer layer is similar to his own Tongcheonui (armillary sphere) which is a kind of armillary sphere. Honsang sphere which correspond to inner layer depicts constellations and milky way and two beads hang on it as Sun and Moon respectively for realize the celestial motion. Tongcheonui is operated by the pendulum power but Honsangui is operated by water-hammering method mechanism. This Honsangui's working mechanism is the traditional way of Joseon and it was simplified the working mechanism of Shui y'n i hsiang t'ai which is a representative astronomical clock of China. This record of Honsangui is the only historical record about the water-hammering method working mechanism of Joseon Era and it provide the study of water-hammering method mechanism with a vital clue.

  7. Art as a Political Act: Expression of Cultural Identity, Self-Identity, and Gender by Suk Nam Yun and Yong Soon Min

    ERIC Educational Resources Information Center

    Caruso, Hwa Young Choi

    2005-01-01

    This cross-cultural study explored the lives of two contemporary Korean/Korean American women artists--Suk Nam Yun and Yong Soon Min--who live in Seoul, South Korea, and Los Angeles, California. The author's research focused on the artists' identity formation, artistic expression, professional achievements, and the role of art as a political act.…

  8. Climate and Man (Selected Articles),

    DTIC Science & Technology

    1985-08-09

    6). Large Caucasus. (7). True altitude, m. a - Alibek; b - Sheki; c - Zakataly; d - Yevlakh; e - Kirovabad; f - Zurnabad; g -Shusha; h - Kedabek...b 10 8 a Ff. M., C m np Ro s a E. 11., q aa 1 4 . r7. 0nmTr pexpea- umwuoueILHKII TeppHT~pHHf MOCKoRCKolk oOAaCTH Ro *pH3HoAoro- KAH marH te - CKNM...MACHINE TRANSLATION FTD-ID(RS)T-1542-84 9 August 1985 MICROFICHE NR: FTD-85- C -Ooo647 CLIMATE AND MAN (Selected Articles) English pages: 171 Source: Klimat

  9. Application Side Casing on Open Deck RoRo to Improve Ship Stability

    NASA Astrophysics Data System (ADS)

    Hasanudin; K. A. P Utama, I.; Chen, Jeng-Horng

    2018-03-01

    RoRo is a vessel that can transport passengers, cargo, container and cars. Open Car Deck is favourite RoRo Vessel in developing countries due to its small GT, small tax and spacious car deck, but it has poor survival of stability. Many accident involve Open Car Deck RoRo which cause fatalities and victim. In order to ensure the safety of the ship, IMO had applied intact stability criteria IS Code 2008 which adapted from Rahola’s Research, but since 2008 IMO improved criteria become probabilistic damage stability SOLAS 2009. The RoRo type Open Car Deck has wide Breadth (B), small Draft (D) and small freeboard. It has difficulties to satisfy the ship’s stability criteria. Side Casings which has been applied in some RoRo have be known reduce freeboard or improve ship’s safety. In this paper investigated the effect side casings to survival of intact dan damage ship’s stability. Calculation has been conducted for four ships without, existing and full side casings. The investigation results shows that defect stability of Open Deck RoRo can be reduce with fitting side casing.

  10. 29 CFR 1918.86 - Roll-on roll-off (Ro-Ro) operations (see also § 1918.2, Ro-Ro operations, and § 1918.25).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... simultaneous use of the ramp by vehicles and pedestrians. (d) Ramp maintenance. Ramps shall be properly... ramp inclines safely. (j) Safe speeds. Power driven vehicles used in Ro-Ro operations shall be operated at speeds that are safe for prevailing conditions. (k) Ventilation. Internal combustion engine-driven...

  11. 29 CFR 1918.86 - Roll-on roll-off (Ro-Ro) operations (see also § 1918.2, Ro-Ro operations, and § 1918.25).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Ro-Ro operations, and § 1918.25). 9 [Reserved] (a) Traffic control system. An organized system of... simultaneous use of the ramp by vehicles and pedestrians. (d) Ramp maintenance. Ramps shall be properly...: (1) Sufficient power to ascend ramp inclines safely; and (2) Sufficient braking capacity to descend...

  12. 29 CFR 1918.86 - Roll-on roll-off (Ro-Ro) operations (see also § 1918.2, Ro-Ro operations, and § 1918.25).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., Ro-Ro operations, and § 1918.25). 9 [Reserved] (a) Traffic control system. An organized system of vehicular and pedestrian traffic control shall be established and maintained at each entrance/exit ramp and on ramps within the vessel as traffic flow warrants. (b) Ramp load limit. Each ramp shall be plainly...

  13. 29 CFR 1918.86 - Roll-on roll-off (Ro-Ro) operations (see also § 1918.2, Ro-Ro operations, and § 1918.25).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., Ro-Ro operations, and § 1918.25). 9 [Reserved] (a) Traffic control system. An organized system of vehicular and pedestrian traffic control shall be established and maintained at each entrance/exit ramp and on ramps within the vessel as traffic flow warrants. (b) Ramp load limit. Each ramp shall be plainly...

  14. 29 CFR 1918.86 - Roll-on roll-off (Ro-Ro) operations (see also § 1918.2, Ro-Ro operations, and § 1918.25).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., Ro-Ro operations, and § 1918.25). 9 [Reserved] (a) Traffic control system. An organized system of vehicular and pedestrian traffic control shall be established and maintained at each entrance/exit ramp and on ramps within the vessel as traffic flow warrants. (b) Ramp load limit. Each ramp shall be plainly...

  15. The Assessment of the Ultimate Hull Girder Strength of RO-RO Ship after Damages

    NASA Astrophysics Data System (ADS)

    Zubair Muis Alie, Muhammad; Sitepu, Ganding; Izaak Latumahin, Samuel

    2018-03-01

    Many accidents of Ro-Ro ships happen in Indonesia such as collision and grounding. When the collision or grounding takes place on the Ro-Ro ship, the ultimate strength of hull structure after damage becomes decrease. Car and passenger decks are critical location since collision and/or grounding occur. In the present study, the assessment of the ultimate hull girder strength is conducted. The cross section of Ro-Ro ship is taken to be analyzed. The collision and grounding damages are assumed to be palced on the side and bottom area, respectively. The damages are created by removing the element from the side shell and bottom part. Finally, the result obtained is compared with one another.

  16. Translations on North Korea. Number 616.

    DTIC Science & Technology

    1978-09-20

    Chin-u, Kye Ung -tae, Kim -hwan, Kim Man-kum, Ho Tam, Chong Chun-ki and Kong Chin-tae. Attending the soiree were Comrade Han Tok-su, chairman of the...Committee which was held on 10 June under the leadership of Kim Il-song; listed ninth, after Kim Tu- yong and before No T’ae-sok (NODONG SINMUN 12 Jun...Province KWP Committee which was held on 10 June under the leadership of Kim Il-song; listed seventh, after Kang Song-san and before Kim Tu- yong

  17. SU-E-T-218: The IHE-RO Helper Tool: Demonstrating the Connectivity Issues Solved by IHE-RO.

    PubMed

    Kapoor, Rishabh; Yeung, Daniel; Kumar, Sabari Ajay; Alex, Daley; Kapur, Priyanka; Palta, Jatinder

    2012-06-01

    To develop a Web-based application (IHE-RO Helper) to allow comprehensive review of the interconnectivity and interoperability of various radiotherapy devices established through testing sanctioned by the Integrating Healthcare Enterprise-Radiation Oncology (IHE-RO). IHE-RO is an initiative sponsored by ASTRO to improve the way computer based systems in radiation oncology share information using well-defined data exchange standards (DICOM / HL7). At the IHE-RO Connectathon events over the last 4 years, 11 vendors with 14 different products have successfully tested and identified solutions to connectivity problems in treatment planning, simulation and delivery. Because the test results are highly technical, the interconnectivity issues amongst the RT devices may get overlooked by the end users. The IHE-RO helper tool is designed to operate in simple clinical terms with queries and presentations organized based on treatment techniques and clinical features that are familiar to the practitioners. For example, if you are planning to purchase a treatment planning system capable of generating plans (e.g. Stereotactic treatments) and are concerned whether the TPS can successfully transfer such data to your treatment management system (TMS) and subsequently to your treatment delivery system (TDS), the IHE-RO Helper can identify the connectivity requirements and list vendors that have successfully passed an IHE-RO Connectathon and validated their solution to the specific requirements. The IHE-RO helper tool provides a graphical and textual user interface to effectively demonstrate the solved interconnectivity problems between TPS, TMS and TDS. A report is also provided that explains the interconnectivity problems and its solutions. The IHE-RO helper is an effective tool to clearly identify vendor products that are IHE-RO compliant, thereby encourages vendor participation in testing and validation. Such a tool will be invaluable in procurement of new equipment to ensure a

  18. Ground-based photometric support for the CoRoT mission by the CoRoT-Hungarian Asteroseismology Group

    NASA Astrophysics Data System (ADS)

    Bognár, Zs.; Paparó, M.

    2012-12-01

    The CoRoT-Hungarian Asteroseismology Group was established in 2005 and joined the preparatory work of the CoRoT Mission via an ESA PECS project. After the successful launch of the telescope, we have continued our work of ground-based multi-colour photometric observations and contributed to the analyses of CoRoT data. Our observations were focused on δ Scuti, γ Doradus, and RR Lyrae stars. The follow-up of some selected targets' pulsations in different wavelengths has provided valuable information for mode identification. We provided additional support by the confirmation of relatively faint variables' spectral types. We proved that our ground-based observations can help in the interpretation of a target with a contaminated CoRoT light curve. In this paper, we summarize our most important results of the photometric support for the CoRoT Mission. The CoRoT space mission was developed and is operated by the French space agency CNES, with participation of ESA's RSSD and Science Programmes, Austria, Belgium, Brazil, Germany, and Spain.

  19. IgV peptide mapping of native Ro60 autoantibody proteomes in primary Sjögren's syndrome reveals molecular markers of Ro/La diversification.

    PubMed

    Wang, Jing J; Al Kindi, Mahmood A; Colella, Alex D; Dykes, Lukah; Jackson, Michael W; Chataway, Tim K; Reed, Joanne H; Gordon, Tom P

    2016-12-01

    We have used high-resolution mass spectrometry to sequence precipitating anti-Ro60 proteomes from sera of patients with primary Sjögren's syndrome and compare immunoglobulin variable-region (IgV) peptide signatures in Ro/La autoantibody subsets. Anti-Ro60 were purified by elution from native Ro60-coated ELISA plates and subjected to combined de novo amino acid sequencing and database matching. Monospecific anti-Ro60 Igs comprised dominant public and minor private sets of IgG1 kappa and lambda restricted heavy and light chains. Specific IgV amino acid substitutions stratified anti-Ro60 from anti-Ro60/La responses, providing a molecular fingerprint of Ro60/La determinant spreading and suggesting that different forms of Ro60 antigen drive these responses. Sequencing of linked anti-Ro52 proteomes from individual patients and comparison with their anti-Ro60 partners revealed sharing of a dominant IGHV3-23/IGKV3-20 paired clonotype but with divergent IgV mutational signatures. In summary, anti-Ro60 IgV peptide mapping provides insights into Ro/La autoantibody diversification and reveals serum-based molecular markers of humoral Ro60 autoimmunity. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Observational studies of roAp stars

    NASA Astrophysics Data System (ADS)

    Sachkov, M.

    2014-11-01

    Rapidly oscillating Ap (roAp) stars are high-overtone, low-degree p-mode pulsators that are also chemically peculiar magnetic A stars. Until recently the classical asteroseismic analysis i.e. frequency analysis, of these stars was based on ground and space photometric observations. Significant progress was achieved through access to uninterrupted, ultra-high-precision data from MOST, COROT and Kepler satellites. Over the last ten years the study of roAp stars has been altered drastically from an observational point of view through studies of time-resolved, high-resolution spectra. Their unusual pulsational characteristics, caused by an interplay between the short vertical lengths of the pulsation waves and strong stratification of chemical elements, allow us to examine the upper roAp atmosphere in more detail than is possible for any star except the Sun. In this paper I review the results of recent studies of the pulsations of roAp stars.

  1. Man-systems integration and the man-machine interface

    NASA Technical Reports Server (NTRS)

    Hale, Joseph P.

    1990-01-01

    Viewgraphs on man-systems integration and the man-machine interface are presented. Man-systems integration applies the systems' approach to the integration of the user and the machine to form an effective, symbiotic Man-Machine System (MMS). A MMS is a combination of one or more human beings and one or more physical components that are integrated through the common purpose of achieving some objective. The human operator interacts with the system through the Man-Machine Interface (MMI).

  2. Integrated pharmacokinetics and pharmacodynamics of Ro 48-8684, a new benzodiazepine, in comparison with midazolam during first administration to healthy male subjects.

    PubMed

    van Gerven, J M; Roncari, G; Schoemaker, R C; Massarella, J; Keesmaat, P; Kooyman, H; Heizmann, P; Zell, M; Cohen, A F; Dingemanse, J

    1997-11-01

    This study aimed to investigate the pharmacodynamics and pharmacokinetics of ascending doses of Ro 48-8684, compared with midazolam, in healthy subjects during first administration to man. The study was double-blind and five-way crossover (three ascending doses, placebo, fixed midazolam dose), performed in two groups of five males. Ro 48-8684 was infused in doses of 0.1-0.3-1 mg in the first group, and 1-3-10 mg in the second, with different infusion rates (expressed as mg min(-1)) among doses. Midazolam was infused at 0.1 mg(-1) kg. Infusions were stopped after 20 min or if sedation became too strong for proper performance of saccadic eye movements. Pharmacokinetics and pharmacodynamics and their relationships were evaluated as described in the companion article. Ro 48-8684 caused dose-dependent sedation. No serious adverse events occurred. The volume of distribution and clearance of Ro 48-8684 were larger than of midazolam (337+/-114 vs 50+/-121 and 2.4+/-0.5 vs 0.47+/-0.11 l min(-1), resp). The recovery of saccadic eye movements from equal levels of sedation was on average almost half an hour faster for Ro 48-8684 than for midazolam, with considerable interindividual differences (range 2, 55 min). The doses of Ro 48-8684 leading to the same clinical endpoint as midazolam were comparable, but the corresponding predicted effect compartment concentrations of Ro 48-8684 were on average 2.6 times lower (range 1.5, 4.9 times). The slope of the linear concentration-effect-relationship for saccadic peak velocity was on average 2.2 times steeper for 10 mg Ro 48-8684 than for midazolam (range 1.3, 3.3). The slope decreased on average 4.4-fold (range 1.6, 7.3 times), with doses of Ro 48-8684 increasing from 1 to 10 mg. The metabolite Ro 61-2466 had a longer half-life than the parent compound Ro 48-8684. The influence of this metabolite during prolonged administration should be further investigated. These results show that Ro 48-8684 has a considerably shorter duration of

  3. The imidazobenzodiazepine Ro 15-4513 antagonizes methoxyflurane anesthesia.

    PubMed

    Moody, E J; Skolnick, P

    1988-01-01

    Parenteral administration of the imidazobenzodiazepine Ro 15-4513 (a high affinity ligand of the benzodiazepine receptor with partial inverse agonist qualities) produced a dose dependent reduction in sleep time of mice exposed to the inhalation anesthetic, methoxyflurane. The reductions in methoxyflurane sleep time ranged from approximately 20% at 4 mg/kg to approximately 38% at 32 mg/kg of Ro 15-4513. Co-administration of the benzodiazepine receptor antagonist Ro 15-1788 (16 mg/kg) or the inverse agonists DMCM (5-20 mg/kg) and FG 7142 (22.5 mg/kg) blocks this effect which suggests that the reductions in methoxyflurane sleep time produced by Ro 15-4513 are mediated via occupation of benzodiazepine receptors. Moreover, neither DMCM (5-20 mg/kg) nor FG 7142 (22.5 mg/kg) reduced methoxyflurane sleep time which suggests this effect of Ro 15-4513 cannot be attributed solely to its partial inverse agonist properties. These observations support recent findings that inhalation anesthetics may produce their depressant effects via perturbation of the benzodiazepine/GABA receptor chloride channel complex, and suggest that Ro 15-4513 may serve as a prototype of agents capable of antagonizing the depressant effects of inhalation anesthetics such as methoxyflurane.

  4. CoRoTlog

    NASA Astrophysics Data System (ADS)

    Plasson, Ph.

    2006-11-01

    LESIA, in close cooperation with CNES, DLR and IWF, is responsible for the tests and validation of the CoRoT instrument digital process unit which is made up of the BEX and DPU assembly. The main part of the work has consisted in validating the DPU software and in testing the BEX/DPU coupling. This work took more than two years due to the central role of the software tested and its technical complexity. The first task, in the validation process, was to carry out the acceptance tests of the DPU software. These tests consisted in checking each of the 325 requirements identified in the URD (User Requirements Document) and were played in a configuration using the DPU coupled to a BEX simulator. During the acceptance tests, all the transversal functionalities of the DPU software, like the TC/TM management, the state machine management, the BEX driving, the system monitoring or the maintenance functionalities were checked in depth. The functionalities associated with the seismology and exoplanetology processing, like the loading of window and mask descriptors or the configuration of the service execution parameters, were also exhaustively tested. After having validated the DPU software against the user requirements using a BEX simulator, the following step consisted in coupling the DPU and the BEX in order to check that the formed unit worked correctly and met the performance requirements. These tests were conducted in two phases: the first one was devoted to the functional aspects and the tests of interface, the second one to the performance aspects. The performance tests were based on the use of the DPU software scientific services and on the use of full images representative of a realistic sky as inputs. These tests were also based on the use of a reference set of windows and parameters, which was provided by the scientific team and was representative, in terms of load and complexity, of the one that could be used during the observation mode of the CoRoT instrument

  5. Stellar Rotation: New Insight from CoRoT

    NASA Astrophysics Data System (ADS)

    Catala, C.; Goupil, M. J.; Michel, E.; Baglin, A.; de Medeiros, J. Renan; Gondoin, Ph.

    2009-02-01

    We present an overview of the new insight provided by the CoRoT satellite on stellar rotation. Thanks to its ultra-high precision, high duty cycle, long photometric monitoring of thousands of stars, CoRoT gives us a powerful tool to study stellar rotational modulation, and therefore to measure stellar rotational periods and to study active structures at the surface of stars. This paper presents preliminary results concerning this type of study. CoRoT will also provide us with an insight of internal stellar rotation via the measurement and exploitation of rotational splittings of oscillation modes. This approach to stellar rotation with CoRoT will require a careful analysis of the oscillation power spectra, which is in progress, but prospects for such measurements are presented.

  6. SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jauharoh, Siti Nur Aisyah; Faculty of Medicine and Health Science, Syarif Hidayatullah State Islamic University, Jakarta 15412; Saegusa, Jun

    Highlights: Black-Right-Pointing-Pointer Ro52{sup low} HeLa cells are resistant to apoptosis upon various stimulations. Black-Right-Pointing-Pointer Ro52 is upregulated by IFN-{alpha}, etoposide, or IFN-{gamma} and anti-Fas Ab. Black-Right-Pointing-Pointer Ro52-mediated apoptosis is independent of p53. Black-Right-Pointing-Pointer Ro52 selectively regulates Bcl-2 expression. -- Abstract: SS-A/Ro52 (Ro52), an autoantigen in systemic autoimmune diseases such as systemic lupus erythematosus and Sjoegren's syndrome, has E3 ligase activity to ubiquitinate proteins that protect against viral infection. To investigate Ro52's role during stress, we transiently knocked it down in HeLa cells by siRo52 transfection. We found that Ro52{sup low} HeLa cells were significantly more resistant to apoptosis than wild-typemore » HeLa cells when stimulated by H{sub 2}O{sub 2}- or diamide-induced oxidative stress, IFN-{alpha}, IFN-{gamma} and anti-Fas antibody, etoposide, or {gamma}-irradiation. Furthermore, Ro52-mediated apoptosis was not influenced by p53 protein level in HeLa cells. Depleting Ro52 in HeLa cells caused Bcl-2, but not other Bcl-2 family molecules, to be upregulated. Taken together, our data showed that Ro52 is a universal proapoptotic molecule, and that its proapoptotic effect does not depend on p53, but is exerted through negative regulation of the anti-apoptotic protein Bcl-2. These findings shed light on a new physiological role for Ro52 that is important to intracellular immunity.« less

  7. [Research on Japanese monograph of comprehensive dietetic materia medica, the Pao chu bei yong wo ming ben cao (Japanese Materia Medica Prepared for Kitchen)].

    PubMed

    Zhou, M; Ye, J

    2017-11-28

    Japanese physicians of Edo Period (1603-1867) wrote many dietetic books, by combining the knowledge system (content and compiling style) and thoughts of diet therapy from China with local condition in Japan. Among them, the Pao chu bei yong wo ming ben cao ( Japanese Materia Medica Prepared for Kitchen ), written by Mukai Genshou, a physician in the early Edo, is the earliest comprehensive work of dietetic materia medica. In this book, the choice and usage of Japanese dietetic materia medica reveals obvious Japanese local color, including the name, morphology, cultivation, collection, identification, nature and flavor, and indication etc., reflecting the sprouting idea of edible herbal plant at the beginning of Edo period and the characteristic of absorbing Chinese diet thoughts by Japanese physician. This is the important first-hand historical material to understand the development of Japanese dietetic herbalism in early Edo and its dietotherapy culture.

  8. Dexpanthenol (Ro 01-4709) in the treatment of constipation.

    PubMed

    Hanck, A B; Goffin, H

    1982-01-01

    Functional constipation is not a life-threatening disease, but as a chronic state it worries the patient and causes him discomfort and often leads him to self-medication with potentially dangerous drugs. Ro 01-4709 contains as active substance dexpanthenol, which is the alcohol of pantothenic acid, a vitamin of the B-complex. In the cells, dexpanthenol is readily oxidized to pantothenic acid, which stimulates peristalsis when administered in therapeutically effective doses. Ro 01-4709 has already proven its efficacy in the prevention and treatment of adynamic ileus. Recently, several open and two double-blind studies have been carried out, investigating the efficacy of oral Ro 01-4709 in the treatment of chronic functional constipation. The two double-blind studies showed Ro 01-4709 to be superior to placebo in all parameters measured. The studies with an open design also demonstrated a favourable effect of Ro 01-4709 in the treatment of chronic functional constipation. Owing to its physiological action-which is in a favourable contrast to that of normal laxatives. Ro 01-4709 can be recommended for the treatment of functional constipation in pregnant women, children and the elderly.

  9. Can PC-9 Zhong chong replace K-1 Yong quan for the acupunctural resuscitation of a bilateral double-amputee? Stating the “random criterion problem” in its statistical analysis

    PubMed Central

    Inchauspe, Adrián Angel

    2016-01-01

    AIM: To present an inclusion criterion for patients who have suffered bilateral amputation in order to be treated with the supplementary resuscitation treatment which is hereby proposed by the author. METHODS: This work is based on a Retrospective Cohort model so that a certainly lethal risk to the control group is avoided. RESULTS: This paper presents a hypothesis on acupunctural PC-9 Zhong chong point, further supported by previous statistical work recorded for the K-1 Yong quan resuscitation point. CONCLUSION: Thanks to the application of the resuscitation maneuver herein proposed on the previously mentioned point, patients with bilateral amputation would have another alternative treatment available in case basic and advanced CPR should fail. PMID:27152257

  10. From State-controlled to Polycentric Governance in Forest Landscape Restoration: The Case of the Ecological Forest Purchase Program in Yong'an Municipality of China.

    PubMed

    Long, Hexing; Liu, Jinlong; Tu, Chengyue; Fu, Yimin

    2018-07-01

    Forest landscape restoration is emerging as an effective approach to restore degraded forests for the provision of ecosystem services and to minimize trade-offs between conservation and rural livelihoods. Policy and institutional innovations in China illustrate the governance transformation of forest landscape restoration from state-controlled to polycentric governance. Based on a case study of the Ecological Forest Purchase Program in Yong'an municipality, China's Fujian Province, this paper explores how such forest governance transformation has evolved and how it has shaped the outcomes of forest landscape restoration in terms of multi-dimensionality and actor configurations. Our analysis indicates that accommodating the participation of multiple actors and market-based instruments facilitate a smoother transition from state-centered to polycentric governance in forest landscape restoration. Governance transitions for forest landscape restoration must overcome a number of challenges including ensurance of a formal participation forum, fair participation, and a sustainable legislative and financial system to enhance long-term effectiveness.

  11. 77 FR 47275 - Airworthiness Directives; HPH s. r.o. Sailplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-08

    ... Airworthiness Directives; HPH s. r.o. Sailplanes AGENCY: Federal Aviation Administration (FAA), Department of... s. r.o. Models 304C, 304CZ, and 304CZ-17 sailplanes. This AD results from mandatory continuing... information identified in this AD, contact HPH spol. s. r.o., [Ccaron][aacute]slavsk[aacute] 126, P.O. Box 112...

  12. 77 FR 33127 - Airworthiness Directives; HPH s. r.o. Sailplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ...-0598; Directorate Identifier 2012-CE-017-AD] RIN 2120-AA64 Airworthiness Directives; HPH s. r.o... all HPH s. r.o. Models 304C, 304CZ, and 304CZ-17 sailplanes. This proposed AD results from mandatory... information identified in this proposed AD, contact HPH spol. s r.o., [Ccaron][aacute]slavsk[aacute] 126, P.O...

  13. SyRoTek--Distance Teaching of Mobile Robotics

    ERIC Educational Resources Information Center

    Kulich, M.; Chudoba, J.; Kosnar, K.; Krajnik, T.; Faigl, J.; Preucil, L.

    2013-01-01

    E-learning is a modern and effective approach for training in various areas and at different levels of education. This paper gives an overview of SyRoTek, an e-learning platform for mobile robotics, artificial intelligence, control engineering, and related domains. SyRoTek provides remote access to a set of fully autonomous mobile robots placed in…

  14. Gas-Phase Ozonolysis of Cycloalkenes: Formation of Highly Oxidized RO2 Radicals and Their Reactions with NO, NO2, SO2, and Other RO2 Radicals.

    PubMed

    Berndt, Torsten; Richters, Stefanie; Kaethner, Ralf; Voigtländer, Jens; Stratmann, Frank; Sipilä, Mikko; Kulmala, Markku; Herrmann, Hartmut

    2015-10-15

    The gas-phase reaction of ozone with C5-C8 cycloalkenes has been investigated in a free-jet flow system at atmospheric pressure and a temperature of 297 ± 1 K. Highly oxidized RO2 radicals bearing at least 5 O atoms in the molecule and their subsequent reaction products were detected in most cases by means of nitrate-CI-APi-TOF mass spectrometry. Starting from a Criegee intermediate after splitting-off an OH-radical, the formation of these RO2 radicals can be explained via an autoxidation mechanism, meaning RO2 isomerization (ROO → QOOH) and subsequently O2 addition (QOOH + O2 → R'OO). Time-dependent RO2 radical measurements concerning the ozonolysis of cyclohexene indicate rate coefficients of the intramolecular H-shifts, ROO → QOOH, higher than 1 s(-1). The total molar yield of highly oxidized products (predominantly RO2 radicals) from C5-C8 cycloalkenes in air is 4.8-6.0% affected with a calibration uncertainty by a factor of about two. For the most abundant RO2 radical from cyclohexene ozonolysis, O,O-C6H7(OOH)2O2 ("O,O" stands for two O atoms arising from the ozone attack), the determination of the rate coefficients of the reaction with NO2, NO, and SO2 yielded (1.6 ± 0.5) × 10(-12), (3.4 ± 0.9) × 10(-11), and <10(-14) cm(3) molecule(-1) s(-1), respectively. The reaction of highly oxidized RO2 radicals with other peroxy radicals (R'O2) leads to detectable accretion products, RO2 + R'O2 → ROOR' + O2, which allows to acquire information on peroxy radicals not directly measurable with the nitrate ionization technique applied here. Additional experiments using acetate as the charger ion confirm conclusively the existence of highly oxidized RO2 radicals and closed-shell products. Other reaction products, detectable with this ionization technique, give a deeper insight in the reaction mechanism of cyclohexene ozonolysis.

  15. An update on finances and financial support for medical students in Yong Loo Lin School of Medicine

    PubMed Central

    Sayampanathan, Andrew Arjun; Tan, Yeong Tze Wilnard; Fong, Jie Ming Nigel; Koh, Yun Qing; Ng, Chew Lip; Mohan, Niraj; Jang, Jin Hao Justin; Tambyah, Paul Anantharajah

    2017-01-01

    INTRODUCTION Increasing financial challenges have resulted in great debt among medical graduates worldwide. In Singapore, more scholarships and bursaries have been disbursed in recent years to support students who are financially challenged. We aimed to study the financial status of medical students in National University of Singapore (NUS) Yong Loo Lin School of Medicine (i.e. NUS Medicine), Singapore, and the financial support available to them. METHODS A cross-sectional quantitative study was performed. Surveys were distributed and completed by medical students of NUS Medicine. Information regarding household income, financial assistance, monthly allowance and expense, and concurrent occupations was collected. We compared our findings with the results of a similar study performed in 2007 and national income data. RESULTS A total of 956 (66.2%) out of 1,445 medical students completed the survey. 19.5% and 58.5% of respondents came from households with monthly incomes < SGD 3,000 and > SGD 7,000, respectively. 20.6% of students had loans, 18.9% had scholarships and bursaries, and 14.4% worked to support themselves. CONCLUSION Medical school fees have risen by more than 50% over the past ten years. Our study found that there were increases in the proportion of students from both the lower- and higher-income segments, with proportionally fewer students from the middle-income segment. A large number of students were working and/or had some form of financial support. More should be done to meet the needs of financially challenged medical students to ensure equal access to quality medical education. PMID:27516114

  16. Ro small cytoplasmic ribonucleoproteins are a subclass of La ribonucleoproteins: further characterization of the Ro and La small ribonucleoproteins from uninfected mammalian cells.

    PubMed Central

    Hendrick, J P; Wolin, S L; Rinke, J; Lerner, M R; Steitz, J A

    1981-01-01

    Small ribonucleic acid (RNA)-protein complexes precipitated by anti-Ro and anti-La antibodies from lupus patients have been examined with emphasis on their RNA components. In both ribonucleoprotein (RNP) classes, the numbers of different RNA molecules and their sequences vary between mouse and human cells. The complex mixtures of La RNAs include two previously sequenced 4.5S RNAs from mouse cells and 5S ribosomal RNA-like molecules from both mouse and human cells. All Ro and La RNAs possess 5-triphosphates. Some La RNAs have internal modifications typical of transfer RNAs. The Ro RNPs are quite stable and are localized by immunofluorescence in the cell cytoplasm, whereas the majority of the La RNPs turn over rapidly and reside in the nucleus. Despite these differences, reconstitution experiments show that the Ro particles carry the La as well as the Ro determinant. Studies using a nuclear transcription system demonstrate that most of the La RNAs are synthesized by RNA polymerase III. The possibility that the La protein(s) functions in the transcription or maturation of all RNA polymerase III transcripts is discussed. Images PMID:6180298

  17. Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes.

    PubMed

    Fouraux, Michael A; Bouvet, Philippe; Verkaart, Sjoerd; van Venrooij, Walther J; Pruijn, Ger J M

    2002-07-12

    Ro RNPs are evolutionarily conserved, small cytoplasmic RNA-protein complexes with an unknown function. In human cells, Ro RNPs consist of one of the four hY RNAs and two core proteins: Ro60 and La. Recently, the association of hnRNP I and hnRNP K with particles containing hY1 and hY3 RNAs has been described. The association of three other proteins, namely calreticulin, Ro52 and RoBPI, with (subsets of) the Ro RNPs is still controversial. To gain more insight into the composition and function of the Ro RNPs, we have immunopurified these particles from HeLa cell extracts using monoclonal antibodies against Ro60 and La. Using this approach, we have identified the RNA-binding protein nucleolin as a novel subunit of Ro RNP particles containing hY1 or hY3 RNA, but not hY4 and hY5 RNA. Using an in vitro hY RNA-binding assay we established that the internal pyrimidine-rich loop of hY1 and hY3 RNA is essential for the association of nucleolin. The binding is critically dependent on the presence of all four RNP motifs of nucleolin, but not of the C-terminal RGG-box. Moreover, we demonstrate that, in contrast to nucleolin and hnRNP K, nucleolin and hnRNP I can bind simultaneously to the internal pyrimidine-rich loop of hY1 RNA. We postulate that nucleolin functions in the biogenesis and/or trafficking of hY1 and hY3 RNPs through the nucleolus and subsequent transport to the cytoplasm. (c) 2002 Elsevier Science Ltd.

  18. AstRoMap European Astrobiology Roadmap

    PubMed Central

    Horneck, Gerda; Westall, Frances; Grenfell, John Lee; Martin, William F.; Gomez, Felipe; Leuko, Stefan; Lee, Natuschka; Onofri, Silvano; Tsiganis, Kleomenis; Saladino, Raffaele; Pilat-Lohinger, Elke; Palomba, Ernesto; Harrison, Jesse; Rull, Fernando; Muller, Christian; Strazzulla, Giovanni; Brucato, John R.; Rettberg, Petra; Capria, Maria Teresa

    2016-01-01

    Abstract The European AstRoMap project (supported by the European Commission Seventh Framework Programme) surveyed the state of the art of astrobiology in Europe and beyond and produced the first European roadmap for astrobiology research. In the context of this roadmap, astrobiology is understood as the study of the origin, evolution, and distribution of life in the context of cosmic evolution; this includes habitability in the Solar System and beyond. The AstRoMap Roadmap identifies five research topics, specifies several key scientific objectives for each topic, and suggests ways to achieve all the objectives. The five AstRoMap Research Topics are • Research Topic 1: Origin and Evolution of Planetary Systems• Research Topic 2: Origins of Organic Compounds in Space• Research Topic 3: Rock-Water-Carbon Interactions, Organic Synthesis on Earth, and Steps to Life• Research Topic 4: Life and Habitability• Research Topic 5: Biosignatures as Facilitating Life Detection It is strongly recommended that steps be taken towards the definition and implementation of a European Astrobiology Platform (or Institute) to streamline and optimize the scientific return by using a coordinated infrastructure and funding system. Key Words: Astrobiology roadmap—Europe—Origin and evolution of life—Habitability—Life detection—Life in extreme environments. Astrobiology 16, 201–243. PMID:27003862

  19. RoMPS concept review automatic control of space robot

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The Robot operated Material Processing in Space (RoMPS) experiment is being performed to explore the marriage of two emerging space commercialization technologies: materials processing in microgravity and robotics. This concept review presents engineering drawings and limited technical descriptions of the RoMPS programs' electrical and software systems.

  20. Asteroseismology of OB stars with CoRoT

    NASA Astrophysics Data System (ADS)

    Degroote, P.; Aerts, C.; Samadi, R.; Miglio, A.; Briquet, M.; Auvergne, M.; Baglin, A.; Baudin, F.; Catala, C.; Michel, E.

    2010-12-01

    The CoRoT satellite is revolutionizing the photometric study of massive O-type and B-type stars. During its long runs, CoRoT observed the entire main sequence B star domain, from typical hot β Cep stars, via cooler hybrid p- and g-mode pulsators to the SPB stars near the edge of the instability strip. CoRoT lowers the sensitivity barrier from the typical mmag-precision reached from the ground, to the μmag-level reached from space. Within the wealth of detected and identified pulsation modes, relations have been found in the form of multiplets, combination of frequencies, and frequency- and period spacings. This wealth of observational evidence is finally providing strong constraints to test current models of the internal structure and pulsations of hot stars. Aside from the expected opacity driven modes with infinite lifetime, other unexpected types of variability are detected in massive stars, such as modes of stochastic nature. The simultaneous observation of all these light curve characteristics implies a challenge for both observational asteroseismology and stellar modelling. The CoRoT space mission was developed and is operated by the French space agency CNES, with participation of ESA's RSSD and Science Programmes, Austria, Belgium, Brazil, Germany, and Spain.

  1. CoRoT-7b: SUPER-EARTH OR SUPER-Io?

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barnes, Rory; Kaib, Nathan A.; Raymond, Sean N.

    2010-02-01

    CoRoT-7b, a planet about 70% larger than the Earth orbiting a Sun-like star, is the first-discovered rocky exoplanet, and hence has been dubbed a 'super-Earth'. Some initial studies suggested that since the planet is so close to its host star, it receives enough insolation to partially melt its surface. However, these past studies failed to take into consideration the role that tides may play in this system. Even if the planet's eccentricity has always been zero, we show that tidal decay of the semimajor axis could have been large enough that the planet formed on a wider orbit which receivedmore » less insolation. Moreover, CoRoT-7b could be tidally heated at a rate that dominates its geophysics and drives extreme volcanism. In this case, CoRoT-7b is a 'super-Io' that, like Jupiter's volcanic moon, is dominated by volcanism and rapid resurfacing. Such heating could occur with an eccentricity of just 10{sup -5}. This small value could be driven by CoRoT-7c if its own eccentricity is larger than {approx}10{sup -4}. CoRoT-7b may be the first of a class of planetary super-Ios likely to be revealed by the CoRoT and Kepler spacecraft.« less

  2. Transiting exoplanets from the CoRoT space mission. VIII. CoRoT-7b: the first super-Earth with measured radius

    NASA Astrophysics Data System (ADS)

    Léger, A.; Rouan, D.; Schneider, J.; Barge, P.; Fridlund, M.; Samuel, B.; Ollivier, M.; Guenther, E.; Deleuil, M.; Deeg, H. J.; Auvergne, M.; Alonso, R.; Aigrain, S.; Alapini, A.; Almenara, J. M.; Baglin, A.; Barbieri, M.; Bruntt, H.; Bordé, P.; Bouchy, F.; Cabrera, J.; Catala, C.; Carone, L.; Carpano, S.; Csizmadia, Sz.; Dvorak, R.; Erikson, A.; Ferraz-Mello, S.; Foing, B.; Fressin, F.; Gandolfi, D.; Gillon, M.; Gondoin, Ph.; Grasset, O.; Guillot, T.; Hatzes, A.; Hébrard, G.; Jorda, L.; Lammer, H.; Llebaria, A.; Loeillet, B.; Mayor, M.; Mazeh, T.; Moutou, C.; Pätzold, M.; Pont, F.; Queloz, D.; Rauer, H.; Renner, S.; Samadi, R.; Shporer, A.; Sotin, Ch.; Tingley, B.; Wuchterl, G.; Adda, M.; Agogu, P.; Appourchaux, T.; Ballans, H.; Baron, P.; Beaufort, T.; Bellenger, R.; Berlin, R.; Bernardi, P.; Blouin, D.; Baudin, F.; Bodin, P.; Boisnard, L.; Boit, L.; Bonneau, F.; Borzeix, S.; Briet, R.; Buey, J.-T.; Butler, B.; Cailleau, D.; Cautain, R.; Chabaud, P.-Y.; Chaintreuil, S.; Chiavassa, F.; Costes, V.; Cuna Parrho, V.; de Oliveira Fialho, F.; Decaudin, M.; Defise, J.-M.; Djalal, S.; Epstein, G.; Exil, G.-E.; Fauré, C.; Fenouillet, T.; Gaboriaud, A.; Gallic, A.; Gamet, P.; Gavalda, P.; Grolleau, E.; Gruneisen, R.; Gueguen, L.; Guis, V.; Guivarc'h, V.; Guterman, P.; Hallouard, D.; Hasiba, J.; Heuripeau, F.; Huntzinger, G.; Hustaix, H.; Imad, C.; Imbert, C.; Johlander, B.; Jouret, M.; Journoud, P.; Karioty, F.; Kerjean, L.; Lafaille, V.; Lafond, L.; Lam-Trong, T.; Landiech, P.; Lapeyrere, V.; Larqué, T.; Laudet, P.; Lautier, N.; Lecann, H.; Lefevre, L.; Leruyet, B.; Levacher, P.; Magnan, A.; Mazy, E.; Mertens, F.; Mesnager, J.-M.; Meunier, J.-C.; Michel, J.-P.; Monjoin, W.; Naudet, D.; Nguyen-Kim, K.; Orcesi, J.-L.; Ottacher, H.; Perez, R.; Peter, G.; Plasson, P.; Plesseria, J.-Y.; Pontet, B.; Pradines, A.; Quentin, C.; Reynaud, J.-L.; Rolland, G.; Rollenhagen, F.; Romagnan, R.; Russ, N.; Schmidt, R.; Schwartz, N.; Sebbag, I.; Sedes, G.; Smit, H.; Steller, M. B.; Sunter, W.; Surace, C.; Tello, M.; Tiphène, D.; Toulouse, P.; Ulmer, B.; Vandermarcq, O.; Vergnault, E.; Vuillemin, A.; Zanatta, P.

    2009-10-01

    Aims: We report the discovery of very shallow (Δ F/F ≈ 3.4× 10-4), periodic dips in the light curve of an active V = 11.7 G9V star observed by the CoRoT satellite, which we interpret as caused by a transiting companion. We describe the 3-colour CoRoT data and complementary ground-based observations that support the planetary nature of the companion. Methods: We used CoRoT colours information, good angular resolution ground-based photometric observations in- and out- of transit, adaptive optics imaging, near-infrared spectroscopy, and preliminary results from radial velocity measurements, to test the diluted eclipsing binary scenarios. The parameters of the host star were derived from optical spectra, which were then combined with the CoRoT light curve to derive parameters of the companion. Results: We examined all conceivable cases of false positives carefully, and all the tests support the planetary hypothesis. Blends with separation >0.40´´or triple systems are almost excluded with a 8 × 10-4 risk left. We conclude that, inasmuch we have been exhaustive, we have discovered a planetary companion, named CoRoT-7b, for which we derive a period of 0.853 59 ± 3 × 10-5 day and a radius of Rp = 1.68 ± 0.09 R_Earth. Analysis of preliminary radial velocity data yields an upper limit of 21 M_Earth for the companion mass, supporting the finding. Conclusions: CoRoT-7b is very likely the first Super-Earth with a measured radius. This object illustrates what will probably become a common situation with missions such as Kepler, namely the need to establish the planetary origin of transits in the absence of a firm radial velocity detection and mass measurement. The composition of CoRoT-7b remains loosely constrained without a precise mass. A very high surface temperature on its irradiated face, ≈1800-2600 K at the substellar point, and a very low one, ≈50 K, on its dark face assuming no atmosphere, have been derived. The CoRoT space mission, launched on 27

  3. Downregulation of active IKKβ by Ro52-mediated autophagy

    PubMed Central

    Niida, Motoko; Tanaka, Makoto; Kamitani, Tetsu

    2010-01-01

    Upon activation, NF-κB translocates into the nucleus and initiates many biological events. This NF-κB signaling is mainly induced by the protein kinase IKKβ. Early in this signaling pathway, IKKβ is phosphorylated for activation by several factors, such as pro-inflammatory cytokines and the Tax oncoprotein of human T-cell leukemia virus type 1 (HTLV-1). In cells expressing Tax protein, IKKβ is persistently phosphorylated, which chronically activates NF-κB signaling. But the active IKKβ is conjugated with a monoubiquitin by the E3 ubiquitin ligase Ro52, and the IKKβ-induced NF-κB signaling is downregulated. However, the mechanism of the downregulation has been unknown. Here, we show that Ro52-mediated monoubiquitination is involved in the subcellular translocation of active IKKβ to autophagosomes. Furthermore, using reporter assays, we show that Ro52 suppresses IKKβ-induced NF-κB signaling and that this suppression is blocked by an autophagy inhibitor. These results suggest that Ro52-mediated monoubiquitination plays a critical role in the downregulation of active IKKβ through autophagy. PMID:20627395

  4. Validation of Robotic Surgery Simulator (RoSS).

    PubMed

    Kesavadas, Thenkurussi; Stegemann, Andrew; Sathyaseelan, Gughan; Chowriappa, Ashirwad; Srimathveeravalli, Govindarajan; Seixas-Mikelus, Stéfanie; Chandrasekhar, Rameella; Wilding, Gregory; Guru, Khurshid

    2011-01-01

    Recent growth of daVinci Robotic Surgical System as a minimally invasive surgery tool has led to a call for better training of future surgeons. In this paper, a new virtual reality simulator, called RoSS is presented. Initial results from two studies - face and content validity, are very encouraging. 90% of the cohort of expert robotic surgeons felt that the simulator was excellent or somewhat close to the touch and feel of the daVinci console. Content validity of the simulator received 90% approval in some cases. These studies demonstrate that RoSS has the potential of becoming an important training tool for the daVinci surgical robot.

  5. Is ultraviolet radiation on haemodialysis RO water beneficial?

    PubMed

    Stragier, A

    2005-01-01

    The quality of dialysis fluids has become increasingly important in the treatment of HD patients. Purified water represents over 95% of its volume. Bacterial and endotoxin content of Reverse Osmosis (RO) water is usually kept under control by bacterial filters, inserted in the distribution departure loop, and by monthly disinfection of the distribution circuit; the simpler the circuit, the better. This paper reports 12 years experience during which Ultraviolet Irradiation (UV) has replaced bacterial filters. To keep the bacterial growth under control in a complex RO water circuit (including a tank and multiple loops) a simple UV lamp was inserted in the departure line. It proved sufficient to keep bacterial count within AAMI norms. Failure of the UV lamp was associated with a rise of up to 500 cfu/ml in the last (fourth week) before routine disinfection. Normal levels were again obtained after replacement of the UV lamp. Six years later, a second UV lamp was added on the return loop. Bacterial counts and endotoxin levels in RO water promptly fell to <1 cfu/ml and <0.125 EU, till today. It is concluded that UV lamps should be favoured over bacterial filters in systems that are not disinfected daily, such as the RO water circuit. The principle of UV irradiation is explained and its advantage over bacterial filters is discussed. Future possible applications of UV are presented.

  6. 77 FR 23806 - Manning Rail, Inc.-Acquisition and Operation Exemption-Manning Grain Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-20

    ... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35607] Manning Rail, Inc.--Acquisition and Operation Exemption--Manning Grain Company Manning Rail, Inc. (MRI), a noncarrier, has filed a verified notice of exemption \\1\\ under 49 CFR 1150.31 to acquire from Manning Grain Company (MGC) and operate a 7.1-mile rail line...

  7. CD45RO enriches for activated, highly mutated human germinal center B cells

    PubMed Central

    Jackson, Stephen M.; Harp, Natessa; Patel, Darshna; Zhang, Jeffrey; Willson, Savannah; Kim, Yoon J.; Clanton, Christian

    2007-01-01

    To date, there is no consensus regarding the influence of different CD45 isoforms during peripheral B-cell development. Examining correlations between surface CD45RO expression and various physiologic processes ongoing during the germinal center (GC) reaction, we hypothesized that GC B cells, like T cells, that up-regulate surface RO should progressively acquire phenotypes commonly associated with activated, differentiating lymphocytes. GC B cells (IgD−CD38+) were subdivided into 3 surface CD45RO fractions: RO−, RO+/−, and RO+. We show here that the average number of mutations per IgVH transcript increased in direct correlation with surface RO levels. Conjunctional use of RO and CD69 further delineated low/moderately and highly mutated fractions. Activation-induced cytidine deaminase (AID) mRNA was slightly reduced among RO+ GC B cells, suggesting that higher mutation averages are unlikely due to elevated somatic mutation activity. Instead, RO+ GC B cells were negative for Annexin V, comprised mostly (93%) of CD77− centrocytes, and were enriched for CD69+ cells. Collectively, RO+ GC B cells occupy what seems to be a specialized niche comprised mostly of centrocytes that may be in transition between activation states. These findings are among the first to sort GC B cells into populations enriched for live mutated cells solely using a single extracellular marker. PMID:17644737

  8. Transiting exoplanets from the CoRoT space mission. XI. CoRoT-8b: a hot and dense sub-Saturn around a K1 dwarf

    NASA Astrophysics Data System (ADS)

    Bordé, P.; Bouchy, F.; Deleuil, M.; Cabrera, J.; Jorda, L.; Lovis, C.; Csizmadia, S.; Aigrain, S.; Almenara, J. M.; Alonso, R.; Auvergne, M.; Baglin, A.; Barge, P.; Benz, W.; Bonomo, A. S.; Bruntt, H.; Carone, L.; Carpano, S.; Deeg, H.; Dvorak, R.; Erikson, A.; Ferraz-Mello, S.; Fridlund, M.; Gandolfi, D.; Gazzano, J.-C.; Gillon, M.; Guenther, E.; Guillot, T.; Guterman, P.; Hatzes, A.; Havel, M.; Hébrard, G.; Lammer, H.; Léger, A.; Mayor, M.; Mazeh, T.; Moutou, C.; Pätzold, M.; Pepe, F.; Ollivier, M.; Queloz, D.; Rauer, H.; Rouan, D.; Samuel, B.; Santerne, A.; Schneider, J.; Tingley, B.; Udry, S.; Weingrill, J.; Wuchterl, G.

    2010-09-01

    Aims: We report the discovery of CoRoT-8b, a dense small Saturn-class exoplanet that orbits a K1 dwarf in 6.2 days, and we derive its orbital parameters, mass, and radius. Methods: We analyzed two complementary data sets: the photometric transit curve of CoRoT-8b as measured by CoRoT and the radial velocity curve of CoRoT-8 as measured by the HARPS spectrometer. Results: We find that CoRoT-8b is on a circular orbit with a semi-major axis of 0.063 ± 0.001 AU. It has a radius of 0.57 ± 0.02 RJ, a mass of 0.22 ± 0.03 MJ, and therefore a mean density of 1.6 ± 0.1 g cm-3. Conclusions: With 67% of the size of Saturn and 72% of its mass, CoRoT-8b has a density comparable to that of Neptune (1.76 g cm-3). We estimate its content in heavy elements to be 47-63 {M}_⊕, and the mass of its hydrogen-helium envelope to be 7-23 {M}_⊕. At 0.063 AU, the thermal loss of hydrogen of CoRoT-8b should be no more than 0.1% over an assumed integrated lifetime of 3 Ga. Observations made with SOPHIE spectrograph at Observatoire de Haute Provence, France (PNP.07B.MOUT), and the HARPS spectrograph at ESO La Silla Observatory (081.C-0388 and 083.C-0186). The CoRoT space mission, launched on December 27, 2006, has been developed and is operated by the CNES with the contribution of Austria, Belgium, Brasil, ESA, Germany, and Spain.Both data sets are available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/520/A66

  9. Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies.

    PubMed

    Kryštůfková, Olga; Barbasso Helmers, Sevim; Venalis, Paulius; Malmström, Vivianne; Lindroos, Eva; Vencovský, Jiří; Lundberg, Ingrid E

    2014-10-10

    Anti-Jo-1 and anti-Ro52 autoantibodies are common in patients with myositis, but the mechanisms behind their production are not known. Survival of autoantibody-producing cells is dependent on B-cell-activating factor of the tumour necrosis factor family (BAFF). BAFF levels are elevated in serum of anti-Jo-1-positive myositis patients and are influenced by type-I interferon (IFN). IFN-producing cells and BAFF mRNA expression are present in myositis muscle. We investigated expression of the receptors for BAFF in muscle tissue in relation to anti-Jo-1 and anti-Ro52/anti-Ro60 autoantibodies and type-I IFN markers. Muscle biopsies from 23 patients with myositis selected based on autoantibody profile and 7 healthy controls were investigated for expression of BAFF receptor (BAFF-R), B-cell maturation antigen (BCMA) and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI). Nineteen samples were assessed for plasma (CD138) and B-cell (CD19) markers. The numbers of positive cells per area were compared with the expression of plasmacytoid dendritic cell (pDC) marker blood dendritic cell antigen-2 (BDCA-2) and IFNα/β-inducible myxovirus resistance-1 protein (MX-1). BAFF-R, BCMA and TACI were expressed in five, seven and seven patients, respectively, and more frequently in anti-Jo-1-positive and/or anti-Ro52/anti-Ro60-positive patients compared to controls and to patients without these autoantibodies (P = BAFF-R: 0.007, BCMA: 0.03 and TACI: 0.07). A local association of receptors with B and plasma cells was confirmed by confocal microscopy. The numbers of CD138-positive and BCMA-positive cells were correlated (r = 0.79; P = 0.001). Expression of BDCA-2 correlated with numbers of CD138-positive cells and marginally with BCMA-positive cells (r = 0.54 and 0.42, respectively; P = 0.04 and 0.06, respectively). There was a borderline correlation between the numbers of positively stained TACI cells and MX-1 areas (r = 0.38, P = 0.08). The expression

  10. RO brine treatment and recovery by biological activated carbon and capacitive deionization process.

    PubMed

    Tao, Guihe; Viswanath, Bala; Kekre, Kiran; Lee, Lai Yoke; Ng, How Yong; Ong, Say Leong; Seah, Harry

    2011-01-01

    The generation of brine solutions from dense membrane (reverse osmosis, RO or nanofiltration, NF) water reclamation systems has been increasing worldwide, and the lack of cost effective disposal options is becoming a critical water resources management issue. In Singapore, NEWater is the product of a multiple barrier water reclamation process from secondary treated domestic effluent using MF/UF-RO and UV technologies. The RO brine (concentrates) accounts for more than 20% of the total flow treated. To increase the water recovery and treat the RO brine, a CDI based process with BAC as pretreatment was tested. The results show that ion concentrations in CDI product were low except SiO2 when compared with RO feed water. CDI product was passed through a RO and the RO permeate was of better quality including low SiO2 as compared to NEWater quality. It could be beneficial to use a dedicated RO operated at optimum conditions with better performance to recover the water. BAC was able to achieve 15-27% TOC removal of RO brine. CDI had been tested at a water recovery ranging from 71.6 to 92.3%. CDI based RO brine treatment could improve overall water recovery of NEWater production over 90%. It was found that calcium phosphate scaling and organic fouling was the major cause of CDI pressure increase. Ozone disinfection and sodium bisulfite dosing were able to reduce CDI fouling rate. For sustainable operation of CDI organic fouling control and effective organic fouling cleaning should be further studied.

  11. Impact of RO-desalted water on distribution water qualities.

    PubMed

    Taylor, J; Dietz, J; Randall, A; Hong, S

    2005-01-01

    A large-scale pilot distribution study was conducted to investigate the impacts of blending different source waters on distribution water qualities, with an emphasis on metal release (i.e. corrosion). The principal source waters investigated were conventionally treated ground water (G1), surface water processed by enhanced treatment (S1), and desalted seawater by reverse osmosis membranes (RO). Due to the nature of raw water quality and associated treatment processes, G1 water had high alkalinity, while S1 and RO sources were characterized as high sulfate and high chloride waters, respectively. The blending ratio of different treated waters determined the quality of finished waters. Iron release from aged cast iron pipes increased significantly when exposed to RO and S1 waters: that is, the greater iron release was experienced with alkalinity reduced below the background of G1 water. Copper release to drinking water, however, increased with increasing alkalinity and decreasing pH. Lead release, on the other hand, increased with increasing chloride and decreasing sulfate. The effect of pH and alkalinity on lead release was not clearly observed from pilot blending study. The flat and compact corrosion scales observed for lead surface exposed to S1 water may be attributable to lead concentration less than that of RO water blends.

  12. Microarray based on autodisplayed Ro proteins for medical diagnosis of systemic lupus erythematosus (SLE).

    PubMed

    Yoo, Gu; Bong, Ji-Hong; Kim, Sinyoung; Jose, Joachim; Pyun, Jae-Chul

    2014-07-15

    A microarray-based immunoassay for the detection of autoantibodies against Ro protein was developed using Escherichia coli with autodisplayed Ro proteins (Ro(+)-E. coli). Patient serum usually contains various antibodies against the outer membrane components of E. coli as well as autoantibodies against the Ro protein. Therefore, the conventional immunoassay based on Ro(+)-E. coli requires both wild type E. coli (blank test) and Ro(+)-E. coli, and both strains of E. coli must be prepared in situ for each individual test serum. In this study, we tested the feasibility of using several types of animal sera as a replacement for individual human sera. An immunoassay without the blank test was developed using Ro(+)-E. coli by (1) blocking with rabbit serum, and (2) cleaving the Fc region from antibodies using papain. Modified E. coli with autodisplayed Ro protein was immobilized to a surface-modified microplate and the applicability of the immunoassay without the blank test was demonstrated using sera from patients with systemic lupus erythematosus (SLE). Using this approach, a microarray-based fluorescence immunoassay with immobilized Ro(+)-E. coli was able to detect anti-Ro autoantibodies in SLE patient sera with high specificity and selectivity and improved efficiency. Copyright © 2014 Elsevier B.V. All rights reserved.

  13. Transiting exoplanets from the CoRoT space mission . VI. CoRoT-Exo-3b: the first secure inhabitant of the brown-dwarf desert

    NASA Astrophysics Data System (ADS)

    Deleuil, M.; Deeg, H. J.; Alonso, R.; Bouchy, F.; Rouan, D.; Auvergne, M.; Baglin, A.; Aigrain, S.; Almenara, J. M.; Barbieri, M.; Barge, P.; Bruntt, H.; Bordé, P.; Collier Cameron, A.; Csizmadia, Sz.; de La Reza, R.; Dvorak, R.; Erikson, A.; Fridlund, M.; Gandolfi, D.; Gillon, M.; Guenther, E.; Guillot, T.; Hatzes, A.; Hébrard, G.; Jorda, L.; Lammer, H.; Léger, A.; Llebaria, A.; Loeillet, B.; Mayor, M.; Mazeh, T.; Moutou, C.; Ollivier, M.; Pätzold, M.; Pont, F.; Queloz, D.; Rauer, H.; Schneider, J.; Shporer, A.; Wuchterl, G.; Zucker, S.

    2008-12-01

    Context: The CoRoT space mission routinely provides high-precision photometric measurements of thousands of stars that have been continuously observed for months. Aims: The discovery and characterization of the first very massive transiting planetary companion with a short orbital period is reported. Methods: A series of 34 transits was detected in the CoRoT light curve of an F3V star, observed from May to October 2007 for 152 days. The radius was accurately determined and the mass derived for this new transiting, thanks to the combined analysis of the light curve and complementary ground-based observations: high-precision radial-velocity measurements, on-off photometry, and high signal-to-noise spectroscopic observations. Results: CoRoT-Exo-3b has a radius of 1.01 ± 0.07 R_Jup and transits around its F3-type primary every 4.26 days in a synchronous orbit. Its mass of 21.66 ± 1.0 M_Jup, density of 26.4 ± 5.6 g cm-3, and surface gravity of logg = 4.72 clearly distinguish it from the regular close-in planet population, making it the most intriguing transiting substellar object discovered so far. Conclusions: With the current data, the nature of CoRoT-Exo-3b is ambiguous, as it could either be a low-mass brown-dwarf or a member of a new class of “superplanets”. Its discovery may help constrain the evolution of close-in planets and brown-dwarfs better. Finally, CoRoT-Exo-3b confirms the trend that massive transiting giant planets (M ≥ 4 M_Jup) are found preferentially around more massive stars than the Sun. The CoRoT space mission, launched on December 27th 2006, has been developed and is operating by CNES, with the contribution of Austria, Belgium, Brasil, ESA, Germany and Spain. The first CoRoT data will be available to the public in February 2009 from the CoRoT archive: http://idoc-corot.ias.u-psud.fr/ Table of the COROT photometry is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http

  14. High-efficient full-duplex WDM-RoF system with sub-central station

    NASA Astrophysics Data System (ADS)

    Liu, Anliang; Yin, Hongxi; Wu, Bin

    2018-05-01

    With an additional sub-central station (S-CS), a high-efficient full-duplex radio-over-fiber (RoF) system compatible with the wavelength-division-multiplexing technology is proposed and experimentally demonstrated in this paper. To improve the dispersion tolerance of the RoF system, the baseband data format for the downlink and an all-optical down-conversion approach for the uplink are employed. In addition, this RoF system can not only make full use of the fiber link resources but also realize the upstream transmission without any local light sources at remote base stations (BSs). A 10-GHz RoF experimental system with a 1.25-Gb/s rate bidirectional transmission is established based on the S-CS structure. The feasibility and reliability of this RoF system are verified through eye diagrams and bit error rate (BER) curves experimentally obtained.

  15. [Expression and clinical significance of CD45RO in laryngeal carcinoma tissue].

    PubMed

    Li, Manyi; Liu, Jishengi; Zhou, Hui; Wu, Wenying; Xiao, Gensheng; Yu, Yafeng; Guo, Lingchuan

    2014-03-01

    To investigate the role and significance of CD45RO in occurance and development in laryngeal squamous carcinoma, and to provide some valuable clues for searching new approaches to assess prognosis and theoretical basis for tumor biotherapy. The expression of CD45RO protein in 50 cases of laryngeal squamous carcinoma and 10 cases normal mucos was detected by immunohistochemical S-P method. The positive rate of CD45RO was 30% and 86% respectively in normal tissue and laryngeal squamous cell carcinoma tissue. The expresion of CD45RO was significantly and negatively associated with local metastatic of lymph nodes 0.713, P < 0.05) and tumor sites (r = -0.750, P < 0.05), but it have no notable difference with pathology differentiation, age, infiltrating depth and clinical stages in 50 cases of laryngeal squamous cell cancer. (1) The expresion of CD45RO in laryngeal squamous cell cancer is more than that in normal tissue. (2) It is possible that overexpresion of CD45RO in laryngeal squamous cell carcinoma cut local metastatic lymph nodes. (3) It is probable that overexpresion of CD45RO in laryngeal squamous cell cancer made for prognosis of patients. (4) Other than UICC-TNM stage, pathology differentiation, it provide valuable clues for searching new approaches to assess prognosis of laryngeal squamous cell carcinoma.

  16. Early infection risk with primary versus staged Hemodialysis Reliable Outflow (HeRO) graft implantation.

    PubMed

    Griffin, Andrew S; Gage, Shawn M; Lawson, Jeffrey H; Kim, Charles Y

    2017-01-01

    This study evaluated whether the use of a staged Hemodialysis Reliable Outflow (HeRO; Merit Medical, South Jordan, Utah) implantation strategy incurs increased early infection risk compared with conventional primary HeRO implantation. A retrospective review was performed of 192 hemodialysis patients who underwent HeRO graft implantation: 105 patients underwent primary HeRO implantation in the operating room, and 87 underwent a staged implantation where a previously inserted tunneled central venous catheter was used for guidewire access for the venous outflow component. Within the staged implantation group, 32 were performed via an existing tunneled hemodialysis catheter (incidentally staged), and 55 were performed via a tunneled catheter inserted across a central venous occlusion in an interventional radiology suite specifically for HeRO implantation (intentionally staged). Early infection was defined as episodes of bacteremia or HeRO infection requiring resection ≤30 days of HeRO implantation. For staged HeRO implantations, the median interval between tunneled catheter insertion and conversion to a HeRO graft was 42 days. The overall HeRO-related infection rate ≤30 days of implantation was 8.6% for primary HeRO implantation and 2.3% for staged implantations (P = .12). The rates of early bacteremia and HeRO resection requiring surgical resection were not significantly different between groups (P = .19 and P = .065, respectively), nor were age, gender, laterality, anastomosis to an existing arteriovenous access, human immunodeficiency virus status, diabetes, steroids, chemotherapy, body mass index, or graft location. None of the patient variables, techniques, or graft-related variables correlated significantly with the early infection rate. The staged HeRO implantation strategy did not result in an increased early infection risk compared with conventional primary implantation and is thus a reasonable strategy for HeRO insertion in hemodialysis patients

  17. Translations on North Korea. Number 534

    DTIC Science & Technology

    1977-06-13

    May 77)... Nature Remaking Work Needed To Occupy Food Grain Height ( Kim Il-song; ALGOK 1,000 MAN TON KOJIRUL CHOMNYONG HAGI WIHAN CHAYON KAEJO...meeting, Choe Yong -kun extended, on the occasion of the "week of support to the struggle of the Palestine people," warm congratu- lations and militant...people. Present at the meeting were Kim Kuk-hun, Yi Chong-mok, and other personages concerned, and working people in the city. Diplomatic envoys of

  18. Technology and the Nature of Man: Biological Considerations. An Occasional Paper on Man/Society/Technology.

    ERIC Educational Resources Information Center

    Sherwood, Lauralee

    This seminar paper explores biological aspects of the man-technology relationship. From man's beginning and continuing into the future, technology is interwoven extensively in the biological fabric of man. Five facets of the biology-technology interaction are examined: (1) technological innovations enabling man to learn about his biological…

  19. Transiting exoplanets from the CoRoT space mission. IV. CoRoT-Exo-4b: a transiting planet in a 9.2 day synchronous orbit

    NASA Astrophysics Data System (ADS)

    Aigrain, S.; Collier Cameron, A.; Ollivier, M.; Pont, F.; Jorda, L.; Almenara, J. M.; Alonso, R.; Barge, P.; Bordé, P.; Bouchy, F.; Deeg, H.; de La Reza, R.; Deleuil, M.; Dvorak, R.; Erikson, A.; Fridlund, M.; Gondoin, P.; Gillon, M.; Guillot, T.; Hatzes, A.; Lammer, H.; Lanza, A. F.; Léger, A.; Llebaria, A.; Magain, P.; Mazeh, T.; Moutou, C.; Paetzold, M.; Pinte, C.; Queloz, D.; Rauer, H.; Rouan, D.; Schneider, J.; Wuchter, G.; Zucker, S.

    2008-09-01

    CoRoT, the first space-based transit search, provides ultra-high-precision light curves with continuous time-sampling over periods of up to 5 months. This allows the detection of transiting planets with relatively long periods, and the simultaneous study of the host star's photometric variability. In this Letter, we report the discovery of the transiting giant planet CoRoT-Exo-4b and use the CoRoT light curve to perform a detailed analysis of the transit and determine the stellar rotation period. The CoRoT light curve was pre-processed to remove outliers and correct for orbital residuals and artefacts due to hot pixels on the detector. After removing stellar variability about each transit, the transit light curve was analysed to determine the transit parameters. A discrete autocorrelation function method was used to derive the rotation period of the star from the out-of-transit light curve. We determine the periods of the planetary orbit and star's rotation of 9.20205 ± 0.00037 and 8.87 ± 1.12 days respectively, which is consistent with this being a synchronised system. We also derive the inclination, i = 90.00_-0.085+0.000 in degrees, the ratio of the orbital distance to the stellar radius, a/Rs = 17.36-0.25+0.05, and the planet-to-star radius ratio R_p/R_s=0.1047-0.0022+0.0041. We discuss briefly the coincidence between the orbital period of the planet and the stellar rotation period and its possible implications for the system's migration and star-planet interaction history. The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA, Germany, and Spain. The first CoRoT data will be available to the public in February 2009 from the CoRoT archive: http://idoc-corot.ias.u-psud.fr/ Figures 1, 4 and 5 are only available in electronic form at http://www.aanda.org

  20. Thematic trip: "Save Roşia MontanÄă"

    NASA Astrophysics Data System (ADS)

    Eugenia, Marcu

    2015-04-01

    The name Roşia Montană, situated in Transylvania, became well known after a Romanian-Canadian company, Roşia Montană Gold Company (RMGC), obtained the concession license on exploitation for gold and silver minerals in the Roşia Montană area. The project consists of opening the largest surface gold mines in Europe using cyanide, which will include four open pits and a processing plant for gold and silver in The Roşia Valley and a tailings facility with an area of 367 hectares in the Corna Valley. One of the main fears is related to a possible ecological accident like the one in Baia Mare in 2000, when a tailing facility dam break led to cyanide pollution of Tisa and Danube rivers that resulted in the death of 1,200 tons of fish and contamination of water resources for 2 million people. This thematic trip is important for the scientific preparation of students and an opportunity to educate them in the spirit of environmental protection. The training and education of students will require assimilation and understanding, actively and consciously, using the knowledge acquired during the compulsory curriculum and training skills. REASON: The continuous degradation of the environment is a major crisis due to human intervention in nature, and the proposed Roşia Montană mining project will continue this trend. The company proposes to extract gold from mines by using the gold separation technique using cyanide, a process that involves destroying a total area of 16 km² which includes 5 mountains, 7 churches, 11 cemeteries and the ruins of Alburnus Maior Citadel, as well as creating pollution that would last for hundreds of years. The extraction of gold from low-grade ores using cyanide processes was estimated to result in a worldwide emission of 45,300 tons of hydrogen cyanide. Environmental education for a healthy life has children as target group, because they are the trustees and beneficiaries of tomorrow's natural resources and can influence the attitudes of

  1. Human Ro60 (SSA2) genomic organization and sequence alterations, examined in cutaneous lupus erythematosus.

    PubMed

    Millard, T P; Ashton, G H S; Kondeatis, E; Vaughan, R W; Hughes, G R V; Khamashta, M A; Hawk, J L M; McGregor, J M; McGrath, J A

    2002-02-01

    The Ro 60 kDa protein (Ro60 or SSA2) is the major component of the Ro ribonucleoprotein (Ro RNP) complex, to which an immune response is a specific feature of several autoimmune diseases. The genomic organization and any sequence variation within the DNA encoding Ro60 are unknown. To characterize the Ro60 gene structure and to assess whether any sequence alterations might be associated with serum anti-Ro antibody in subacute cutaneous lupus erythematosus (SCLE), thus potentially providing new insight into disease pathogenesis. The cDNA sequence for Ro60 was obtained from the NCBI database and used for a BLAST search for a clone containing the entire genomic sequence. The intron-exon borders were confirmed by designing intronic primer pairs to flank each exon, which were then used to amplify genomic DNA for automated sequencing from 36 caucasian patients with SCLE (anti-Ro positive) and 49 with discoid LE (DLE, anti-Ro negative), in addition to 36 healthy caucasian controls. Heteroduplex analysis of polymerase chain reaction (PCR) products from patients and controls spanning all Ro60 exons (1-8) revealed a common bandshift in the PCR products spanning exon 7. Sequencing of the corresponding PCR products demonstrated an A > G substitution at nucleotide position 1318-7, within the consensus acceptor splice site of exon 7 (GenBank XM001901). The allele frequencies were major allele A (0.71) and minor allele G (0.29) in 72 control chromosomes, with no significant differences found between SCLE patients, DLE patients and controls. The genomic organization of the DNA encoding the Ro60 protein is described, including a common polymorphism within the consensus acceptor splice site of exon 7. Our delineation of a strategy for the genomic amplification of Ro60 forms a basis for further examination of the pathological functions of the Ro RNP in autoimmune disease.

  2. Man of Fire.

    ERIC Educational Resources Information Center

    Phipps, Helene Juarez

    1993-01-01

    The themes of Jose Clemente Orozco's murals, several of which are found on U.S. college campuses, are as relevant today as they were during the Mexican Revolution. Orozco (1883-1949) painted the world as he saw it, portraying corruption, violence, and man's inhumanity to man. (LP)

  3. Microorganisms and Man.

    ERIC Educational Resources Information Center

    Noble, W. C.

    1983-01-01

    Provides information to update Institute of Biology's Studies in Biology No. 111, "Microorganisms and Man," by W. C. Noble and Jay Naidoo (Edward Arnold, 1979). Topics include: (1) food poisoning; (2) airborn infections in man; (3) infection in animals and plants; and (4) biodegradation and biosynthesis. (JN)

  4. Rich Man, Poor Man: Developmental Differences in Attributions and Perceptions

    ERIC Educational Resources Information Center

    Sigelman, Carol K.

    2012-01-01

    In an examination guided by cognitive developmental and attribution theory of how explanations of wealth and poverty and perceptions of rich and poor people change with age and are interrelated, 6-, 10-, and 14-year-olds (N = 88) were asked for their causal attributions and trait judgments concerning a rich man and a poor man. First graders, like…

  5. AmeriFlux US-Ro4 Rosemount Prairie

    DOE Data Explorer

    Baker, John [USDA-ARS; Griffis, Tim [University of Minnesota

    2018-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-Ro4 Rosemount Prairie. Site Description - This tower is located in restored prairie in a former agricultural area. Dominant species include Andropogon gerardii, Sorghastrum nutans and Elymus canadensis

  6. Sensitization by SR-2508 plus Ro 03-8799

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stone, H.B.; Luu, Y.H.; Lam, K.N.

    1986-07-01

    The primary toxicity of Ro 03-8799 is a central nervous system toxicity, whereas that of SR-2508 is a peripheral neuropathy. The feasibility of reducing overall toxicity while maintaining maximal radiosensitization by using the two sensitizers together was tested. The LD50/2 of Ro 03-8799 was 0.68 mg/g body wt (mg/gbw) after intravenous (i.v.) administration, and that of SR-2508 was 4.4 mg/gbw after i.v. administration. When both drugs were given together in equitoxic proportions, the LD50/2 was 0.45 mg of Ro 03-8799 plus 2.9 mg of SR-2508/gbw. These doses are 66% of the respective LD50/2 values of the drugs when given separately.more » Radiosensitization was evaluated using in vivo-in vitro assays with EMT6/SF tumors in BALB/c mice. At drug doses between 10 and 60% of the LD50/2, sensitization was generally maximal and similar to that from misonidazole, but there was less sensitization below this dose, both with the drugs given separately and together. If chronic toxicities of these drugs overlap as do the acute toxicities there will be little or no additional benefit from using these drugs in combination, compared to using them separately.« less

  7. On the Use of Topside RO-Derived Electron Density for Model Validation

    NASA Astrophysics Data System (ADS)

    Shaikh, M. M.; Nava, B.; Haralambous, H.

    2018-05-01

    In this work, the standard Abel inversion has been exploited as a powerful observation tool, which may be helpful to model the topside of the ionosphere and therefore to validate ionospheric models. A thorough investigation on the behavior of radio occultation (RO)-derived topside electron density (Ne(h))-profiles has therefore been performed with the main purpose to understand whether it is possible to predict the accuracy of a single RO-retrieved topside by comparing the peak density and height of the retrieved profile to the true values. As a first step, a simulation study based on the use of the NeQuick2 model has been performed to show that when the RO-derived electron density peak and height match the true peak values, the full topside Ne(h)-profile may be considered accurate. In order to validate this hypothesis with experimental data, electron density profiles obtained from four different incoherent scatter radars have therefore been considered together with co-located RO-derived Ne(h)-profiles. The evidence presented in this paper show that in all cases examined, if the incoherent scatter radar and the corresponding co-located RO profile have matching peak parameter values, their topsides are in very good agreement. The simulation results presented in this work also highlighted the importance of considering the occultation plane azimuth while inverting RO data to obtain Ne(h)-profile. In particular, they have indicated that there is a preferred range of azimuths of the occultation plane (80°-100°) for which the difference between the "true" and the RO-retrieved Ne(h)-profile in the topside is generally minimal.

  8. Removing Arsenic with a Softening/RO Combo

    EPA Science Inventory

    This paper provides a very short summary of the arsenic demonstration program and the limited test results from the point-of-use (POU), reverse osmosis (RO) project in Homedale, ID. Preformance data is presented on the effectiveness of the POU treatment system to remove arseni...

  9. Transiting exoplanets from the CoRoT space mission. XXVII. CoRoT-28b, a planet orbiting an evolved star, and CoRoT-29b, a planet showing an asymmetric transit

    NASA Astrophysics Data System (ADS)

    Cabrera, J.; Csizmadia, Sz.; Montagnier, G.; Fridlund, M.; Ammler-von Eiff, M.; Chaintreuil, S.; Damiani, C.; Deleuil, M.; Ferraz-Mello, S.; Ferrigno, A.; Gandolfi, D.; Guillot, T.; Guenther, E. W.; Hatzes, A.; Hébrard, G.; Klagyivik, P.; Parviainen, H.; Pasternacki, Th.; Pätzold, M.; Sebastian, D.; Tadeu dos Santos, M.; Wuchterl, G.; Aigrain, S.; Alonso, R.; Almenara, J.-M.; Armstrong, J. D.; Auvergne, M.; Baglin, A.; Barge, P.; Barros, S. C. C.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Carpano, S.; Chaffey, C.; Deeg, H. J.; Díaz, R. F.; Dvorak, R.; Erikson, A.; Grziwa, S.; Korth, J.; Lammer, H.; Lindsay, C.; Mazeh, T.; Moutou, C.; Ofir, A.; Ollivier, M.; Pallé, E.; Rauer, H.; Rouan, D.; Samuel, B.; Santerne, A.; Schneider, J.

    2015-07-01

    Context. We present the discovery of two transiting extrasolar planets by the satellite CoRoT. Aims: We aim at a characterization of the planetary bulk parameters, which allow us to further investigate the formation and evolution of the planetary systems and the main properties of the host stars. Methods: We used the transit light curve to characterize the planetary parameters relative to the stellar parameters. The analysis of HARPS spectra established the planetary nature of the detections, providing their masses. Further photometric and spectroscopic ground-based observations provided stellar parameters (log g, Teff, v sin i) to characterize the host stars. Our model takes the geometry of the transit to constrain the stellar density into account, which when linked to stellar evolutionary models, determines the bulk parameters of the star. Because of the asymmetric shape of the light curve of one of the planets, we had to include the possibility in our model that the stellar surface was not strictly spherical. Results: We present the planetary parameters of CoRoT-28b, a Jupiter-sized planet (mass 0.484 ± 0.087 MJup; radius 0.955 ± 0.066 RJup) orbiting an evolved star with an orbital period of 5.208 51 ± 0.000 38 days, and CoRoT-29b, another Jupiter-sized planet (mass 0.85 ± 0.20 MJup; radius 0.90 ± 0.16 RJup) orbiting an oblate star with an orbital period of 2.850 570 ± 0.000 006 days. The reason behind the asymmetry of the transit shape is not understood at this point. Conclusions: These two new planetary systems have very interesting properties and deserve further study, particularly in the case of the star CoRoT-29. The CoRoT space mission, launched on December 27th 2006, was developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA (RSSD and Science Programme), Germany, and Spain. Based on observations obtained with the Nordic Optical Telescope, operated on the island of La Palma jointly by Denmark, Finland, Iceland

  10. Neurogenesis enhancer RO 25-6981 facilitates repeated spatial learning in adult rats.

    PubMed

    Soloviova, O A; Proshin, A T; Storozheva, Z I; Sherstnev, V V

    2012-09-01

    The effects of Ro 25-6981 (selective NMDA receptor blocker) in a dose stimulating neurogenesis on repeated learning, reversal learning, and memory reconsolidation were studied in adult rats in Morris water maze. Ro 25-6981 facilitated repeated learning 13 days after injection, but did not influence reversal learning. The blocker injected directly before reminder did not disturb repeated learning and reversal learning in Morris water maze. These effects of Ro 25-6981 on the dynamics of repeated learning seemed to be due to its effects on neurogenesis processes in adult brain.

  11. The Nature of Man and Its Implications.

    ERIC Educational Resources Information Center

    Pedrini, D. T.; Gregory, Lura N.

    The many problems presented by the nature of man and in studying man are the focus of this paper which attempts to place these problems in perspective in terms of the past and future. The enigma facing man, that man must study man, is related in an introduction. Freud's, Adler's, and Jung's developments in the study of the nature of man are…

  12. VizieR Online Data Catalog: CoRoT observation log (N2-4.4) (CoRoT, 2009-2016)

    NASA Astrophysics Data System (ADS)

    COROT Team

    2014-03-01

    CoRoT is a space astronomy mission devoted to the study of the variability with time of stars brightness, with an extremely high accuracy (100 times better than from the ground), on very long durations (up to 150 days) and a very high duty cycle (more than 90%). The mission was led by CNES in association with four french laboratories, and 7 participating countries and agencies (Austria, Belgium, Brazil, Germany, Spain, and the ESA Science Programme). The satellite is composed of a PROTEUS platform (the 3rd in the serie), and a unique instrument: a stellar photometer. It has been launched on December 27th 2006 by a Soyuz Rocket, from Baikonour. The mission has lasted almost 6 years (the nominal 3 years duration and a 3 years extension) and has observed more than 160 000 stars. It stopped to send data suddenly on November 2nd 2012. CoRoT is performing Ultra High Precision Photomery of Stars to detect and characterise the variability of their luminosity with two main directions: - variability of the object itself: oscillations, rotation, magnetic activity - variability due to external causes as bodies in orbit around the star: planets and stars The original scientific objectives were focussed on the study of stellar pulsations (asteroseismology) to probe the internal structure of stars, and the detection of small exoplanets through their "transit in front of their host star, and the measurement of their size. This lead to introduce two modes of observations, working simultaneously: - The bright star mode dedicated to very precise seismology of a small sample of bright and closeby stars (data presented in file momentarily named "astero.dat", but should change in the near future to to "bright star.dat") - The faint star mode, observing a very large number of stars at the same time, to detect transits, which are rare events, as they imply the alignment of the star, the planet and the observer (data presented in momentarily named "exo.dat" but should change in the near

  13. The Green Man

    ERIC Educational Resources Information Center

    Watson-Newlin, Karen

    2010-01-01

    The Jolly Green Giant. Robin Hood. The Bamberg Cathedral. Tales of King Arthur. Ecology. What do they have in common? What legends and ancient myths are shrouded in the tales of the Green Man? Most often perceived as an ancient Celtic symbol as the god of spring and summer, the Green Man disappears and returns year after year, century after…

  14. Translations on North Korea No. 514

    DTIC Science & Technology

    1977-03-11

    Yong -sok, Kim Ch’i-ku, Chi Chae-ryong, 0...Ch’ongjin were the following: Yim Ch’un-ch’u comrade Pak Yong -sok functionary of the sector concerned Kim Ch’i-ku " Chi Chae- yong 0 Hyon-chu Pak...electric railroad on 22 January were the following: Yim Ch’un-ch’u comrade Pak Yong -sok functionary of the sector concerned Kim Ch’i-ku " Chi Chae- yong

  15. The Black Man in American Society.

    ERIC Educational Resources Information Center

    Framingham Public Schools, MA.

    GRADE OR AGES: Junior high school. SUBJECT MATTER: The black man in American society. ORGANIZATION AND PHYSICAL APPEARANCE: There are four major parts each with an overview. The four parts concern a) the African heritage of the black man, b) the American exploitation of the black man, c) the black man's contribution to American society, d) the…

  16. 46 CFR 151.45-3 - Manning.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Manning. 151.45-3 Section 151.45-3 Shipping COAST GUARD... HAZARDOUS MATERIAL CARGOES Operations § 151.45-3 Manning. Except as provided for in this section, barges need not be manned unless in the judgment of the Officer in Charge, Marine Inspection, such manning is...

  17. 46 CFR 151.45-3 - Manning.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Manning. 151.45-3 Section 151.45-3 Shipping COAST GUARD... HAZARDOUS MATERIAL CARGOES Operations § 151.45-3 Manning. Except as provided for in this section, barges need not be manned unless in the judgment of the Officer in Charge, Marine Inspection, such manning is...

  18. 46 CFR 151.45-3 - Manning.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 5 2011-10-01 2011-10-01 false Manning. 151.45-3 Section 151.45-3 Shipping COAST GUARD... HAZARDOUS MATERIAL CARGOES Operations § 151.45-3 Manning. Except as provided for in this section, barges need not be manned unless in the judgment of the Officer in Charge, Marine Inspection, such manning is...

  19. 46 CFR 151.45-3 - Manning.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Manning. 151.45-3 Section 151.45-3 Shipping COAST GUARD... HAZARDOUS MATERIAL CARGOES Operations § 151.45-3 Manning. Except as provided for in this section, barges need not be manned unless in the judgment of the Officer in Charge, Marine Inspection, such manning is...

  20. Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.

    PubMed

    Gao, Jingjing; Yao, Licheng; Xia, Tingting; Liao, Xuebin; Zhu, Deyu; Xiang, Ye

    2018-04-01

    The human kynurenine 3-monooxygenase (hKMO) is a potential therapeutic target for neurodegenerative and neurologic disorders. Inhibition of KMO by Ro 61-8048, a potent, selective, and the most widely used inhibitor of KMO, was shown effective in various models of neurodegenerative or neurologic disorders. However, the molecular basis of hKMO inhibition by Ro 61-8048 is not clearly understood. Here, we report biochemistry studies on hKMO and crystal structures of an hKMO homolog, pfKMO from Pseudomonas fluorescens, in complex with the substrate l-kynurenine and Ro 61-8048. We found that the C-terminal ∼110 aa are essential for the enzymatic activity of hKMO and the homologous C-terminal region of pfKMO folds into a distinct, all-α-helical domain, which associates with the N-terminal catalytic domain to form a unique tunnel in proximity to the substrate-binding pocket. The tunnel binds the Ro 61-8048 molecule, which fills most of the tunnel, and Ro 61-8048 is hydrogen bonded with several completely conserved residues, including an essential catalytic residue. Modification of Ro 61-8048 and biochemical studies of the modified Ro 61-8048 derivatives suggested that Ro 61-8048 inhibits the enzyme in an allosteric manner by affecting the conformation of the essential catalytic residue and by blocking entry of the substrate or product release. The unique binding sites distinguish Ro 61-8048 as a noncompetitive and highly selective inhibitor from other competitive inhibitors, which should facilitate further optimization of Ro 61-8048 and the development of new inhibitory drugs to hKMO.-Gao, J., Yao, L., Xia, T., Liao, X., Zhu, D., Xiang, Y. Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.

  1. Simple, Accurate, Low-cost RO Science with the Iridium-NEXT Satellite Constellation

    NASA Astrophysics Data System (ADS)

    Meehan, T.; Mannucci, A. J.

    2011-12-01

    Over the last decade, a disparate collection of GNSS-RO instruments have been measuring the refractivity of the Earth's ionosphere and atmosphere. These measurements have proven to be robust and precise data sets for operational weather, climate and geospace sciences. Future GNSS-RO weather and science will most benefit from a large number of profiles (10000+/day), with lower latency and greater accuracy in the lowest 5 km altitude. For weather, latencies below 90 minutes are required, 30 minutes desired. Space weather latency requirements are more stringent, with 15 minutes being a long sought goal. Climate studies benefit from averaging measurements uniformly distributed over the Earth, acquired over decades, with local time sampling errors minimized by dense coverage or well designed orbits. There's much more of course, because space GNSS science is still nascent but with gathering momentum among the international community. Although individual GNSS-RO instruments are relatively cheap as space hardware goes, growing the measurement density can be costly when a dozen or more are required for a single program. In this presentation, we propose a novel technique for greatly reducing the cost of a constellation of GNSS-RO instruments and discuss the science trade-offs of this approach versus the more traditional GNSS-RO designs.

  2. MBR/RO/ozone processes for TFT-LCD industrial wastewater treatment and recycling.

    PubMed

    Chen, T K; Ni, C H; Chan, Y C; Lu, M C

    2005-01-01

    This research is mainly to explore the treatment capacity for TFT-LCD industrial wastewater recycling by the processes combined with membrane bioreactor (MBR), reverse osmosis (RO) and ozone(O3). The organic wastewater from the TFT-LCD industry was selected as the target. MBR, RO and ozone plants were established for evaluation. An MBR plant consisted of a 2-stage anoxic/aerobic bioreactor and an immersed UF membrane unit was employed. The effluent of MBR was conducted into the RO system then into the ozone system. The RO system consisted of a spiral membrane in the vessel. One bubble column, 75 cm high and diameter 5 cm, were used as the ozonation reactor. On the bottom of ozonation reactor is a porous diffuser for releasing gas, with an aperture of 100 microm (0.1 cm). Over the whole experimental period, the MBR process achieved a satisfactory organic removal. The COD could be removed with an average of over 98.5%. For the TOC item, the average removal efficiency was 97.4%. The stable effluent quality and satisfactory removal performance were ensured by the efficient interception performance of an immersed UF membrane device incorporated with the biological reactor. Moreover, the MBR effluent did not contain any suspended solids and the SDI value was under 3. After the treatment of RO, excellent water quality was found. The water quality of permeate was under 5 mg/I, 2 mg/l and 50 micros/cm for COD, TOC and conductivity respectively. The treated water can be recycled and reused for the cooling tower make-up water or other purposes. After the treatment of ozone, the treated water quality was under 5 mg/l and 0.852 mg/l for COD and TOC respectively. The test results of MBR, MBR/RO and MBR/RO/ozone processes were compared as possible appropriate treatment technologies applied in TFT-LCD industrial wastewater reuse and recycling.

  3. Photometric variability of the Be star CoRoT-ID 102761769

    NASA Astrophysics Data System (ADS)

    Emilio, M.; Andrade, L.; Janot-Pacheco, E.; Baglin, A.; Gutiérrez-Soto, J.; Suárez, J. C.; de Batz, B.; Diago, P.; Fabregat, J.; Floquet, M.; Frémat, Y.; Huat, A. L.; Hubert, A. M.; Espinosa Lara, F.; Leroy, B.; Martayan, C.; Neiner, C.; Semaan, T.; Suso, J.

    2010-11-01

    Context. Classical Be stars are rapid rotators of spectral type late O to early A and luminosity class V-III, which exhibit Balmer emission lines and often a near infrared excess originating in an equatorially concentrated circumstellar envelope, both produced by sporadic mass ejection episodes. The causes of the abnormal mass loss (the so-called Be phenomenon) are as yet unknown. Aims: For the first time, we can now study in detail Be stars outside the Earth's atmosphere with sufficient temporal resolution. We investigate the variability of the Be Star CoRoT-ID 102761769 observed with the CoRoT satellite in the exoplanet field during the initial run. Methods: One low-resolution spectrum of the star was obtained with the INT telescope at the Observatorio del Roque de los Muchachos. A time series analysis was performed using both cleanest and singular spectrum analysis algorithms to the CoRoT light curve. To identify the pulsation modes of the observed frequencies, we computed a set of models representative of CoRoT-ID 102761769 by varying its main physical parameters inside the uncertainties discussed. Results: We found two close frequencies related to the star. They are 2.465 c d-1 (28.5 μHz) and 2.441 c d-1 (28.2 μHz). The precision to which those frequencies were found is 0.018 c d-1 (0.2 μHz). The projected stellar rotation was estimated to be 120 km s-1 from the Fourier transform of spectral lines. If CoRoT-ID 102761769 is a typical Galactic Be star it rotates near the critical velocity. The critical rotation frequency of a typical B5-6 star is about 3.5 c d-1 (40.5 μHz), which implies that the above frequencies are really caused by stellar pulsations rather than star's rotation. The CoRoT space mission was developed and is operated by the French space agency CNES, with participation of ESA's RSSD and Science Programmes, Austria, Belgium, Brazil, Germany, and Spain.

  4. Sebum-suppressing activity of the nonpolar arotinoid Ro 15-0778 in rodents.

    PubMed

    Boris, A; Hurley, J; Wong, C Q; Comai, K; Shapiro, S

    1988-01-01

    Retinoids are known to modulate sebaceous gland activity in humans and animals. The nonpolar arotinoid Ro 15-0778 [(E)-1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-(1-methyl-2-phenylethen yl) naphthalene] does not contain a polar end group and is devoid of the classical retinoid side effects of hypervitaminosis A. The favorable toxicological profile stimulated the evaluation of this arotinoid in animal models of sebum production. In castrated, testosterone-stimulated male rats, Ro 15-0778 is 50 times more potent than 13-cis-retinoic acid in inhibiting the production and subsequent secretion of sebum. The oral ED50 value of Ro 15-0778 is 30 micrograms/kg, while an oral dose of 0.5 mg/kg inhibited sebum secretion nearly 100%. In testosterone-stimulated female rats, Ro 15-0778 inhibits sebum secretion significantly with an oral ED50 of 140 micrograms/kg and an s.c. ED50 of 75 micrograms/kg. Ro 15-0778 was also evaluated for its ability to prevent testosterone induction of the immature hamster flank organ. The topical ED50 is 0.53 mg/kg and the oral ED50 is 38 mg/kg. This arotinoid is similarly active in mature male hamsters without testosterone treatment. In addition, the retinoid is active topically and orally in reducing the size of the gerbil abdominal sebaceous gland. The compound exhibits no antiandrogenic activity when tested in ventral prostrate and seminal vesicle assays in rats. Additionally, the compound does not have estrogenic activity when tested in the rat uterine weight assay. High doses of Ro 15-0778 in humans did not demonstrate significant sebum-suppressing activity.(ABSTRACT TRUNCATED AT 250 WORDS)

  5. The rights of man and animal experimentation.

    PubMed Central

    Martin, J

    1990-01-01

    Since emotions give contradictory signals about animal experimentation in medical science, man's relationship to animals must be based upon reason. Thomas Aquinas argues that man is essentially different from animals because man's intellectual processes show evidence of an abstract mechanism not possessed by animals. Man's rights arise in association with this essential difference. The consequence is that only man possesses true rights by Aquinas's definition; animals have them only by analogy. However, cruelty to animals is illicit and they should be protected, principally not because they have rights, but because he who is cruel to animals is more likely to be cruel to his fellowman. If there is a need for animal experimentation in science for the good of man, this approach gives philosophical justification for experimentation, since man's well-being must come before that of animals because of his unique possession of rights. However, those experiments should be carried out in the kindest way possible, to promote kindness towards man. To see man as solely part of a biological continuum in competition for rights with those beings close to him biologically, detracts from man's dignity. PMID:2135948

  6. Zonal NePhRO scoring system: a superior renal tumor complexity classification model.

    PubMed

    Hakky, Tariq S; Baumgarten, Adam S; Allen, Bryan; Lin, Hui-Yi; Ercole, Cesar E; Sexton, Wade J; Spiess, Philippe E

    2014-02-01

    Since the advent of the first standardized renal tumor complexity system, many subsequent scoring systems have been introduced, many of which are complicated and can make it difficult to accurately measure data end points. In light of these limitations, we introduce the new zonal NePhRO scoring system. The zonal NePhRO score is based on 4 anatomical components that are assigned a score of 1, 2, or 3, and their sum is used to classify renal tumors. The zonal NePhRO scoring system is made up of the (Ne)arness to collecting system, (Ph)ysical location of the tumor in the kidney, (R)adius of the tumor, and (O)rganization of the tumor. In this retrospective study, we evaluated patients exhibiting clinical stage T1a or T1b who underwent open partial nephrectomy performed by 2 genitourinary surgeons. Each renal unit was assigned both a zonal NePhRO score and a RENAL (radius, exophytic/endophytic properties, nearness of tumor to the collecting system or sinus in millimeters, anterior/posterior, location relative to polar lines) score, and a blinded reviewer used the same preoperative imaging study to obtain both scores. Additional data points gathered included age, clamp time, complication rate, urine leak rate, intraoperative blood loss, and pathologic tumor size. One hundred sixty-six patients underwent open partial nephrectomy. There were 37 perioperative complications quantitated using the validated Clavien-Dindo system; their occurrence was predicted by the NePhRO score on both univariate and multivariate analyses (P = .0008). Clinical stage, intraoperative blood loss, and tumor diameter were all correlated with the zonal NePhRO score on univariate analysis only. The zonal NePhRO scoring system is a simpler tool that accurately predicts the surgical complexity of a renal lesion. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. [Assessment of the efficacy and tolerance of a benzodiazepine antagonist (Ro 15-1788)].

    PubMed

    Rouiller, M; Forster, A; Gemperle, M

    1987-01-01

    The aim of this study was to evaluate the efficacy and the tolerance of Ro 15-1788, a specific benzodiazepine antagonist, in reversing the effects of midazolam. Six healthy male volunteers (mean age 32 +/- 3 years; mean weight 75.5 +/- 5 kg) took part in this study. Two of the three following drugs: midazolam (0.15 mg X kg-1), Ro 15-1788 (0.1 mg X kg-1) or placebo, diluted in 10 ml isotonic saline, were injected intravenously in 15 s at 5 min intervals in a double-blind manner in each subject during six randomized sessions: midazolam-placebo; Ro-placebo; placebo-midazolam; placebo-Ro; midazolam-Ro; Ro-midazolam. At least four days were allowed between each session for each subject. The evaluation of the effects on the central nervous system was as follows. At the time of injection of the first drug and, if possible, at the time of injection of the second drug, the subject was asked to count aloud to 150. The following variables were timed: start of dysarthria, cessation of counting, abolition and duration of absence of the ciliary reflex and duration of induced sleep. Retrograde and anterograde amnesia were evaluated by the recall of a playing card and a number. Haemodynamic effects (variations of systolic and diastolic pressures and pulses rate) as well as respiratory ones (apnoea) were also studied.(ABSTRACT TRUNCATED AT 250 WORDS)

  8. Transiting exoplanets from the CoRoT space mission. XVII. The hot Jupiter CoRoT-17b: a very old planet

    NASA Astrophysics Data System (ADS)

    Csizmadia, Sz.; Moutou, C.; Deleuil, M.; Cabrera, J.; Fridlund, M.; Gandolfi, D.; Aigrain, S.; Alonso, R.; Almenara, J.-M.; Auvergne, M.; Baglin, A.; Barge, P.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Bruntt, H.; Carone, L.; Carpano, S.; Cavarroc, C.; Cochran, W.; Deeg, H. J.; Díaz, R. F.; Dvorak, R.; Endl, M.; Erikson, A.; Ferraz-Mello, S.; Fruth, Th.; Gazzano, J.-C.; Gillon, M.; Guenther, E. W.; Guillot, T.; Hatzes, A.; Havel, M.; Hébrard, G.; Jehin, E.; Jorda, L.; Léger, A.; Llebaria, A.; Lammer, H.; Lovis, C.; MacQueen, P. J.; Mazeh, T.; Ollivier, M.; Pätzold, M.; Queloz, D.; Rauer, H.; Rouan, D.; Santerne, A.; Schneider, J.; Tingley, B.; Titz-Weider, R.; Wuchterl, G.

    2011-07-01

    We report on the discovery of a hot Jupiter-type exoplanet, CoRoT-17b, detected by the CoRoT satellite. It has a mass of 2.43 ± 0.30 MJup and a radius of 1.02 ± 0.07 RJup, while its mean density is 2.82 ± 0.38 g/cm3. CoRoT-17b is in a circular orbit with a period of 3.7681 ± 0.0003 days. The host star is an old (10.7 ± 1.0 Gyr) main-sequence star, which makes it an intriguing object for planetary evolution studies. The planet's internal composition is not well constrained and can range from pure H/He to one that can contain ~380 earth masses of heavier elements. The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA (RSSD and Science Programme), Germany and Spain. Part of the observations were obtained at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council of Canada, the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique of France, and the University of Hawaii. Based on observations made with HARPS spectrograph on the 3.6-m European Organisation for Astronomical Research in the Southern Hemisphere telescope at La Silla Observatory, Chile (ESO program 184.C-0639). Based on observations made with the IAC80 telescope operated on the island of Tenerife by the Instituto de Astrofísica de Canarias in the Spanish Observatorio del Teide. Part of the data presented herein were obtained at the W.M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W.M. Keck Foundation.

  9. Roles and needs of man in space

    NASA Technical Reports Server (NTRS)

    Von Puttkamer, J.

    1983-01-01

    Human capabilities and requirements on space missions are discussed. Utilitarian and humanistic motivations for manned missions are considered, and a general program of development from easy space access and return, to a permanent LEO presence, to the limited self-sufficiency of man in space, is proposed. Man's potential as scientific observer, operator, and engineer/technician is illustrated with examples from the Apollo and Skylab missions. It is shown that future increases in man's space presence will require significant improvements in habitation technology, crew comfort and safety, operational effectiveness and reliability, and man/machine interactions: man-tended systems must be standardized and adapted to (mainly EVA) human servicing; permanently manned systems must be designed to attain levels of comfort, privacy, and overall habitability more like those expected on the ground.

  10. Transpiration Rate for Chile Peppers Irrigated with Brackish Groundwater and ro Concentrate

    NASA Astrophysics Data System (ADS)

    Shukla, M. K.; Baath, G.

    2016-12-01

    Fresh water availability is declining in most of the semi-arid and arid regions across the world including southwestern United States. Use of marginal quality groundwater has been increasing for sustaining agriculture in these arid regions. Reverse Osmosis (RO) can treat brackish groundwater but the possibility of using RO concentrate for irrigation needs further exploration. This greenhouse study evaluates the transpiration rate, water use, leaching fraction and yield responses of five selected chile pepper (Capsicum annuum) cultivars irrigated with natural brackish groundwater and RO concentrate. The four saline water treatments used for irrigation were tap water of EC 0.6 (control), ground water of EC 3 and 5 dS/m and RO concentrate of EC 8 dS/m. The transpiration of all chile peppers cultivars decreased and leaching fraction increased with increasing irrigation water salinity. Based on the water use efficiency (WUEY) of selected chile pepper cultivars, brackish water of EC ≤ 3 dS/m can be used for irrigation. The average yield of chile peppers was stable up to a saturated soil paste extract electrical conductivity (ECe) of about 2 dS/m, although further increases in ECe resulted in an exponential yield decline. This study showed that yield reductions in chile peppers irrigated with Ca rich brackish groundwater were less than those reported using NaCl dominant saline solution studies. Environmentally safe reuse of RO concentrate could stimulate implementation of inland desalination in water scarce areas and increase greenhouse chile pepper cultivation.

  11. Ro52-mediated Monoubiquitination of IKKβ Down-regulates NF-κB Signalling

    PubMed Central

    Wada, Keiji; Niida, Motoko; Tanaka, Makoto; Kamitani, Tetsu

    2009-01-01

    Upon activation, NF-κB translocates into the nucleus and initiates biological events. This NF-κB signalling is mainly regulated by the protein kinase IKKβ. Early in this signalling pathway, IKKβ is phosphorylated for activation by several factors, such as pro-inflammatory cytokines and the Tax oncoprotein of HTLV-1. In cells infected by HTLV-1, IKKβ is persistently phosphorylated and conjugated with monoubiquitin due to Tax expression. Although this Tax-induced monoubiquitination appears to be an important regulation system for IKKβ, how the monoubiquitination occurs is unknown and its role in NF-κB signalling is still unclear. Here, we show that an E3-ubiquitin ligase Ro52 interacts weakly with wild-type IKKβ but strongly with a phosphomimetic mutant IKKβ to conjugate monoubiquitin in cooperation with an E2-ubiquitin-conjugating enzyme UbcH5B. These results suggest that the Tax-induced phosphorylation of IKKβ causes an interaction with Ro52 for the subsequent monoubiquitination. NF-κB reporter assays have shown that the IKKβ activity is suppressed by wild-type Ro52, but not by its inactive mutant. In addition, monoubiquitin fusion of IKKβ reduced its activity for NF-κB signalling. We also found that Ro52 dramatically reduces the level of Tax. These results suggest that Ro52 down-regulates Tax-induced NF-κB signalling by monoubiquitinating IKKβ and by reducing the level of Tax. PMID:19675099

  12. Colloidal interactions and fouling of NF and RO membranes: a review.

    PubMed

    Tang, Chuyang Y; Chong, T H; Fane, Anthony G

    2011-05-11

    Colloids are fine particles whose characteristic size falls within the rough size range of 1-1000 nm. In pressure-driven membrane systems, these fine particles have a strong tendency to foul the membranes, causing a significant loss in water permeability and often a deteriorated product water quality. There have been a large number of systematic studies on colloidal fouling of reverse osmosis (RO) and nanofiltration (NF) membranes in the last three decades, and the understanding of colloidal fouling has been significantly advanced. The current paper reviews the mechanisms and factors controlling colloidal fouling of both RO and NF membranes. Major colloidal foulants (including both rigid inorganic colloids and organic macromolecules) and their properties are summarized. The deposition of such colloidal particles on an RO or NF membrane forms a cake layer, which can adversely affect the membrane flux due to 1) the cake layer hydraulic resistance and/or 2) the cake-enhanced osmotic pressure. The effects of feedwater compositions, membrane properties, and hydrodynamic conditions are discussed in detail for inorganic colloids, natural organic matter, polysaccharides, and proteins. In general, these effects can be readily explained by considering the mass transfer near the membrane surface and the colloid-membrane (or colloid-colloid) interaction. The critical flux and limiting flux concepts, originally developed for colloidal fouling of porous membranes, are also applicable to RO and NF membranes. For small colloids (diameter≪100 nm), the limiting flux can result from two different mechanisms: 1) the diffusion-solubility (gel formation) controlled mechanism and 2) the surface interaction controlled mechanism. The former mechanism probably dominates for concentrated solutions, while the latter mechanism may be more important for dilute solutions. Future research needs on RO and NF colloidal fouling are also identified in the current paper. Copyright © 2010 Elsevier B

  13. Relation of sensory peripheral neuropathy in Sjögren syndrome to anti-Ro/SSA.

    PubMed

    Scofield, Amanda Kyle; Radfar, Lida; Ice, John A; Vista, Evan; Anaya, Juan-Manuel; Houston, Glen; Lewis, David; Stone, Donald U; Chodosh, James; Hefner, Kimberly; Lessard, Christopher J; Moser, Kathy L; Scofield, Robert Hal

    2012-09-01

    Sjögren syndrome is a common, chronic autoimmune disease that typically produces inflammation and poor function of the salivary and lacrimal glands. Other organs can be affected, including the nervous system. Sensory peripheral neuropathy is a common manifestation of the disease. Eight-eight patients attending a dry eyes-dry mouth clinic were diagnosed to have primary Sjögren syndrome and underwent a neurological examination. Anti-Ro (or SSA) and anti-La (or SSB) were determined using immunodiffusion as well as Inno-Lia and BioPlex ANA screen. Serum vitamin B(12) levels were determined using an enzyme-linked microtiter plate assay. Twenty-seven (31%) of the 88 patients had peripheral neuropathy as defined by loss of light touch, proprioception, or vibratory sensation. Anti-Ro and anti-La were found by immunodiffusion in 12 patients, and 8 of these 12 had neuropathy (χ(2) = 8.46, P = 0.0036, odds ratio = 6.0 compared to those without precipitating anti-Ro and anti-La). Of the 27 patients with only anti-Ro by immunodiffusion, 13 (48.1%) had neuropathy (χ(2) = 5.587, P = 0.018, compared to those without anti-Ro). There was no relationship of the other, more sensitive measures of anti-Ro and anti-La to neuropathy. In addition, we found no association of serum vitamin B(12) levels to neuropathy among these patients with Sjögren syndrome. Sensory peripheral neuropathy is common among patients with Sjögren syndrome and is associated with the presence of anti-Ro and anti-La when determined by immunodiffusion.

  14. The Implementation of Madrasah-Based Management (MBM) at Man 1 and Man 2 Serang City, Banten, Indonesia--A Comparative Study

    ERIC Educational Resources Information Center

    Muhajir

    2016-01-01

    This study aims to reveal how the real condition of management of Madrasah Aliyah Negeri (MAN) or Islamic Senior High School in Serang is, how the understanding of Madrasah-Based Management (MBM) for the people of MAN 2 and MAN 1 Serang is, and how the implementation of MBM in MAN 2 and MAN 1 Serang. This study has a substantial meaning, both…

  15. Editorial Research Reports on Modern Man.

    ERIC Educational Resources Information Center

    Dickinson, William B., Jr., Ed.

    Nine reports published in this volume study the uneasy coexistence of modern man and the complex society he has wrought. Man's apparent disorganized behavior is attributed to his inability to adapt readily to the charged pace of technological change. To combat the advancement of machine over man, he must, therefore, insist that moral and…

  16. Relation of Sensory Peripheral Neuropathy in Sjögren Syndrome to anti-Ro/SSA

    PubMed Central

    Scofield, Amanda K.; Radfar, Lida; Ice, John; Vista, Evan; Anaya, Juan-Manuel; Houston, Glen; Lewis, David; Stone, Donald U.; Chodosh, James; Hefner, Kimberly; Lessard, Christopher J.; Moser, Kathy L.; Scofield, R. Hal

    2013-01-01

    Background Sjögren syndrome is a common, chronic autoimmune disease that typically produces inflammation and poor function of the salivary and lacrimal glands. Other organs can be affected, including the nervous system. Sensory peripheral neuropathy is a common manifestation of the disease. Methods Eight-eight patients attending a dry eyes-dry mouth clinic were classified as primary Sjögren syndrome and underwent a neurological examination. Anti-Ro (or SSA) and anti-La (or SSB) were determined using immunodiffusion as well as Inno-Lia and BioPlex ANA screen. Serum vitamin B12 levels were determined using an enzyme-linked microtiter plate assay. Results Twenty-seven (31%) of the 88 patients had peripheral neuropathy as defined by loss of light touch, proprioception or vibratory sensation. Anti-Ro and anti-La were found by immunodiffusion in 12 patients, and 8 of these 12 had neuropathy (χ2=8.46, p=0.0036, odds ratio = 6.0 compared to those without precipitating anti-Ro and anti-La). Of the 27 patients with only anti-Ro by immunodiffusion, 13 (48.1%) of these had neuropathy (χ2 =5.587, p=0.018 compared to those without anti-Ro). There was no relationship of the other, more sensitive measures of anti-Ro and anti-La to neuropathy. In addition, we found no association of serum vitamin B12 levels to neuropathy among these patients with Sjögren syndrome. Conclusion Sensory peripheral neuropathy is common among patients with Sjögren syndrome, and is associated with the presence of anti-Ro and anti-La when determined by immunodiffusion. PMID:22955477

  17. Noise properties of the CoRoT data. A planet-finding perspective

    NASA Astrophysics Data System (ADS)

    Aigrain, S.; Pont, F.; Fressin, F.; Alapini, A.; Alonso, R.; Auvergne, M.; Barbieri, M.; Barge, P.; Bordé, P.; Bouchy, F.; Deeg, H.; de La Reza, R.; Deleuil, M.; Dvorak, R.; Erikson, A.; Fridlund, M.; Gondoin, P.; Guterman, P.; Jorda, L.; Lammer, H.; Léger, A.; Llebaria, A.; Magain, P.; Mazeh, T.; Moutou, C.; Ollivier, M.; Pätzold, M.; Queloz, D.; Rauer, H.; Rouan, D.; Schneider, J.; Wuchter, G.; Zucker, S.

    2009-10-01

    In this short paper, we study the photometric precision of stellar light curves obtained by the CoRoT satellite in its planet-finding channel, with a particular emphasis on the time scales characteristic of planetary transits. Together with other articles in the same issue of this journal, it forms an attempt to provide the building blocks for a statistical interpretation of the CoRoT planet and eclipsing binary catch to date. After pre-processing the light curves so as to minimise long-term variations and outliers, we measure the scatter of the light curves in the first three CoRoT runs lasting more than 1 month, using an iterative non-linear filter to isolate signal on the time scales of interest. The behaviour of the noise on 2 h time scales is described well by a power-law with index 0.25 in R-magnitude, ranging from 0.1 mmag at R=11.5 to 1 mmag at R=16, which is close to the pre-launch specification, though still a factor 2-3 above the photon noise due to residual jitter noise and hot pixel events. There is evidence of slight degradation in the performance over time. We find clear evidence of enhanced variability on hour time scales (at the level of 0.5 mmag) in stars identified as likely giants from their R magnitude and B-V colour, which represent approximately 60 and 20% of the observed population in the directions of Aquila and Monoceros, respectively. On the other hand, median correlated noise levels over 2 h for dwarf stars are extremely low, reaching 0.05 mmag at the bright end. The CoRoT space mission, launched on December 27, 2006, has been developed and is operated by the CNES, with the contribution of Austria, Belgium, Brazil, ESA, Germany, and Spain. CoRoT data become publicly available one year after release to the Co-Is of the mission from the CoRoT archive: http://idoc-corot.ias.u-psud.fr/.

  18. 46 CFR 151.45-3 - Manning.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Manning. 151.45-3 Section 151.45-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES BARGES CARRYING BULK LIQUID HAZARDOUS MATERIAL CARGOES Operations § 151.45-3 Manning. Except as provided for in this section, barges need not be manned unless in the judgmen...

  19. Manned Mars mission cost estimate

    NASA Technical Reports Server (NTRS)

    Hamaker, Joseph; Smith, Keith

    1986-01-01

    The potential costs of several options of a manned Mars mission are examined. A cost estimating methodology based primarily on existing Marshall Space Flight Center (MSFC) parametric cost models is summarized. These models include the MSFC Space Station Cost Model and the MSFC Launch Vehicle Cost Model as well as other modes and techniques. The ground rules and assumptions of the cost estimating methodology are discussed and cost estimates presented for six potential mission options which were studied. The estimated manned Mars mission costs are compared to the cost of the somewhat analogous Apollo Program cost after normalizing the Apollo cost to the environment and ground rules of the manned Mars missions. It is concluded that a manned Mars mission, as currently defined, could be accomplished for under $30 billion in 1985 dollars excluding launch vehicle development and mission operations.

  20. [Endothelial response for the presence of chosen antinuclear antibodies, anti-Ro (SS-A) and anti-La (SS-B) and anti-Sm in vasculitis against the background of existing lupus erythematosus].

    PubMed

    Doskocz, R; Adamiec, R; Kwiatkowska, W; Alexewicz, P; Doskocz, W; Adamiec, J

    1999-11-01

    Systemic lupus erythematodes is a disease commonly associated with peripheric circulation disturbances. The goal of the study was the evaluation of the role of the following nuclear antibodies: anti-Ro (SS-A), anti-La (SS-B) and anti-Sm in the endothelium damage process in the SLE patients with symptoms of microcirculation disturbances. The concentration of plasma thrombomodulin was used as a marker of the endothelium destructive changes intensity. Twenty-four patients with SLE (22 women and 2 man) aged of 18-57 (the average age 40.50 +/- 9.72 years) in which occurred: the Raynauds symptom (16 patients), fingers cyanosis (5 patients) and fingers and/or toes necrosis (3 patients) were investigated. Antinuclear antibodies and thrombomodulin level was estimated with the ELISA method. In all patients, the concentration of anticardiolipin antibodies in serum was determined (ELISA-method, cardiolipin was used as an antigenes, Sigma USA). Higher titers of ANA antibodies in 83%, anti-SM antibodies in 30%, anti-Ro in 42% and anti-La in 42%, examined patients and higher titer of anti-Ro and anti-La antibodies together in 29% of examined patients were stated. Statistical significant correlation between the increased level of thrombomodulin and anti-La antibodies concentrations in serum of patients with the disease lasting over 6 years was found out. The significant statistical correlation of thrombomodulin concentration increasing and anti-La antibodies in serum was proved. The dynamism of limbs circulation disorders depends on the disease duration.

  1. MO-AB-204-01: IHE RO Overview [Health Care

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hadley, S.

    You’ve experienced the frustration: vendor A’s device claims to work with vendor B’s device, but the practice doesn’t match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information. This is done by coordinating the use of published standardsmore » like DICOM and HL7. Several clinical and operational IHE domains exist in the healthcare arena, including Radiology and Radiation Oncology. The ASTRO-sponsored IHE Radiation Oncology (IHE-RO) domain focuses on radiation oncology specific information exchange. This session will explore the IHE Radiology and IHE RO process for; IHE solicitation process for new profiles. Improving the way computer systems interconnect and exchange information in the healthcare enterprise Supporting interconnectivity descriptions and proof of adherence by vendors Testing and assuring the vendor solutions to connectivity problems. Including IHE profiles in RFPs for future software and hardware purchases. Learning Objectives: Understand IHE role in improving interoperability in health care. Understand process of profile development and implantation. Understand how vendors prove adherence to IHE RO profiles. S. Hadley, ASTRO Supported Activity.« less

  2. Phase Variations, Transits and Eclipses of the Misfit CoRoT-2b

    NASA Astrophysics Data System (ADS)

    Cowan, Nicolas; Deming, Drake; Gillon, Michael; Knutson, Heather; Madhusudhan, Nikku; Rauscher, Emily

    2011-05-01

    We propose to observe the nearby transiting hot Jupiter CoRoT-2b for a little over one planetary orbit on two occasions, yielding two secondary eclipses, a transit, and a full phase curve in each of the 3.6 and 4.5 micron channels. These data will help resolve the unique nature of this bloated planet: CoRoT-2b is the only hot Jupiter that is poorly fit by either inverted or non-inverted spectral models (Deming et al. 2011). Two hypotheses have been proposed to explain the peculiar mid-IR colors of CoRoT-2b, and thermal phase measurements with Spitzer's continuous, high-precision photometry will be able to distinguish between them: the planet has a non-inverted atmosphere but is losing mass to its host star, or the planet has a peculiar kind of temperature inversion due to mysterious atmospheric scatterers. CoRoT-2b is also among the most inflated hot Jupiters and, because of its relatively large mass, cannot be reconciled with interior evolution models, despite a small but non-zero eccentricity. A recent planetary collision may be necessary to explain the planet's youthful radius (Guillot & Havel 2011). Finally, the planet's extremely young host star, CoRoT-2, is the most chromospherically active of all transit hosts. This appears to be a common thread connecting all of its planet's peculiarities: the high UV flux of the star will drive mass loss, as well as photochemistry. Most importantly, the radius measurement of the planet at optical wavelengths may be contaminated by star spots. Mid-IR transit measurements from Spitzer will help resolve the mystery of CoRoT-2b's inflated radius.

  3. Stellar map of neolithic man

    NASA Technical Reports Server (NTRS)

    Pskovskiy, Y. P.

    1978-01-01

    Observations made by ancient man are of great interest to present day astronomers. Drawings made by neolithic man in caves show a surprising sense of perspective. The discoveries in the Fern Grotto in California are of special interest. Photographs of cave drawings are included.

  4. Man in space.

    PubMed

    Solovjev, V A

    1987-09-01

    Today, more than 20 years after the first in the world man's space walk, soviet cosmonautics gained large experience of extravehicular activity (EVA). Space suits of high reliability, onboard facilities for passing through the airlock, sets of special tools and technological rigging, as well as procedures for carrying out various EVA's were developed. In the course of the Salyut-7 space station orbital operation the EVA's have become regular. The author of the report as the participant of the EVA's considers the main steps of man activities in space and analyzes specific problems arised in performing such activities.

  5. Computerized Biomechanical Man-Model

    DTIC Science & Technology

    1976-07-01

    Force Systems Command Wright-Patterson AFB, Ohio ABSTRACT The COMputerized BIomechanical MAN-Model (called COMBIMAN) is a computer interactive graphics...concept was to build a mock- The use of mock-ups for biomechanical evalua- up which permitted the designer to visualize the tion has long been a tool...of the can become an obstacle to design change. Aerospace Medical Research Laboratory, we are developing a computerized biomechanical man-model

  6. Korean Affairs Report, No. 315.

    DTIC Science & Technology

    1983-10-24

    assuming the connection with Kim Yong -sam forces, reacted with an unexpectedly resolute stance, aiming its resolute response toward the Kim Yong -sam... Kim Yong -sam, former president of the now-defunct New Democratic Party, to a 10-day detention yesterday. Chon Hong-ki, 31, a member of the Minju...Democratic) Alpine Club, had stood before a summary court on 28 June for having spread printed material on the hunger strike of Kim Yong -sam. He was

  7. Korean Affairs Report No. 308.

    DTIC Science & Technology

    1983-09-14

    Assemblyman Kim Yong -mok said: A tax evasion incident has finally turned into the fraud of the century. National Assemblyman Kim Chae- yong said...Pong Tu-hwan, Chairman of the National Assembly Foreign Affairs Committee, and Kim Yong -tae, the DJP spokesman, answering a reporter’s question on...debts of the Myongsong Group not been mentioned in the tax investigation report?" Representatives Kim Chae- yong , Han Kwang-ok and Hong Sa-tok from the

  8. A New Method for Detecting and Monitoring Atmospheric Natural Hazards with GPS RO

    NASA Astrophysics Data System (ADS)

    Biondi, R.; Steiner, A. K.; Rieckh, T. M.; Kirchengast, G.

    2014-12-01

    Global Positioning System (GPS) Radio Occultation (RO) allows measurements in any meteorological condition, with global coverage, high vertical resolution, and high accuracy. With more than 13 years of data availability, RO also became a fundamental tool for studying climate change. We present here the application of RO for detecting and monitoring tropical cyclones (TCs), deep convective systems (CSs) and volcanic ash clouds (ACs).Deep CSs and TCs play a fundamental role in atmospheric circulation producing vertical transport, redistributing water vapor and trace gases, changing the thermal structure of the Upper Troposphere and Lower Stratosphere (UTLS) and affecting climate through overshooting into the stratosphere. Explosive volcanic eruptions produce large ACs dangerous for the aviation and they can impact climate when the ash is injected into the UTLS.The detection of cloud top height, the determination of cloud extent, the discrimination of ACs from CSs clouds and the detection of overshooting are main challenges for atmospheric natural hazards study. We created a reference atmosphere with a resolution of 5° in latitude and longitude, sampled on a 1° x 1° grid, and a vertical sampling of 100 m. We then compared RO profiles acquired during TCs, CSs and ACs to the reference atmosphere and computed anomaly profiles.CSs, TCs and the ACs leave a clear signature in the atmosphere which can be detected by RO. Using RO temperature and bending angle profiles we gain insight into the vertical thermal structure and developed a new method for detecting the cloud top altitude with high accuracy.We have characterized the TCs by ocean basins and intensities, showing that they have a different thermal structure and reach to different altitudes according to the basin. We provide statistics on overshooting frequency, achieving results consistent with patterns found in the literature and demonstrating that RO is well suited for this kind of study. We have analyzed the

  9. Selective labelling of diazepam-insensitive GABAA receptors in vivo using [3H]Ro 15-4513.

    PubMed

    Pym, Luanda J; Cook, Susan M; Rosahl, Thomas; McKernan, Ruth M; Atack, John R

    2005-11-01

    Classical benzodiazepines (BZs), such as diazepam, bind to GABAA receptors containing alpha1, alpha2, alpha3 or alpha5 subunits that are therefore described as diazepam-sensitive (DS) receptors. However, the corresponding binding site of GABAA receptors containing either an alpha4 or alpha6 subunit do not bind the classical BZs and are therefore diazepam-insensitive (DIS) receptors; a difference attributable to a single amino acid (histidine in alpha1, alpha2, alpha3 and alpha5 subunits and arginine in alpha4 and alpha6). Unlike classical BZs, the imidazobenzodiazepines Ro 15-4513 and bretazenil bind to both DS and DIS populations of GABAA receptors. In the present study, an in vivo assay was developed using lorazepam to fully occupy DS receptors such that [3H]Ro 15-4513 was then only able to bind to DIS receptors. When dosed i.v., [3H]Ro 15-4513 rapidly entered and was cleared from the brain, with approximately 70% of brain radioactivity being membrane-bound. Essentially all membrane binding to DS+DIS receptors could be displaced by unlabelled Ro 15-4513 or bretazenil, with respective ID50 values of 0.35 and 1.2 mg kg(-1). A dose of 30 mg kg(-1) lorazepam was used to block all DS receptors in a [3H]Ro 15-1788 in vivo binding assay. When predosed in a [3H]Ro 15-4513 binding assay, lorazepam blocked [3H]Ro 15-4513 binding to DS receptors, with the remaining binding to DIS receptors accounting for 5 and 23% of the total (DS plus DIS) receptors in the forebrain and cerebellum, respectively. The in vivo binding of [3H]Ro 15-4513 to DIS receptors in the presence of lorazepam was confirmed using alpha1H101R knock-in mice, in which alpha1-containing GABAA receptors are rendered diazepam insensitive by mutation of the histidine that confers diazepam sensitivity to arginine. In these mice, and in the presence of lorazepam, there was an increase of in vivo [3H]Ro 15-4513 binding in the forebrain and cerebellum from 4 and 15% to 36 and 59% of the total (i.e. DS plus DIS) [3H]Ro

  10. Teleoperator systems for manned space missions

    NASA Technical Reports Server (NTRS)

    Interian, A.

    1972-01-01

    The development of remote mechanical systems to augment man's capabilities in our manned space effort is considered. A teleoperator system extends man's innate intelligence and sensory capabilities to distant hostile and hazardous environments through a manipulator-equipped spacecraft and an RF link. Examined are space teleoperator system applications in the space station/space shuttle program, which is where the most immediate need exists and the potential return is greatest.

  11. Man/computer communication in a space environment

    NASA Technical Reports Server (NTRS)

    Hodges, B. C.; Montoya, G.

    1973-01-01

    The present work reports on a study of the technology required to advance the state of the art in man/machine communications. The study involved the development and demonstration of both hardware and software to effectively implement man/computer interactive channels of communication. While tactile and visual man/computer communications equipment are standard methods of interaction with machines, man's speech is a natural media for inquiry and control. As part of this study, a word recognition unit was developed capable of recognizing a minimum of one hundred different words or sentences in any one of the currently used conversational languages. The study has proven that efficiency in communication between man and computer can be achieved when the vocabulary to be used is structured in a manner compatible with the rigid communication requirements of the machine while at the same time responsive to the informational needs of the man.

  12. The ancestry and affiliations of Kennewick Man.

    PubMed

    Rasmussen, Morten; Sikora, Martin; Albrechtsen, Anders; Korneliussen, Thorfinn Sand; Moreno-Mayar, J Víctor; Poznik, G David; Zollikofer, Christoph P E; de León, Marcia Ponce; Allentoft, Morten E; Moltke, Ida; Jónsson, Hákon; Valdiosera, Cristina; Malhi, Ripan S; Orlando, Ludovic; Bustamante, Carlos D; Stafford, Thomas W; Meltzer, David J; Nielsen, Rasmus; Willerslev, Eske

    2015-07-23

    Kennewick Man, referred to as the Ancient One by Native Americans, is a male human skeleton discovered in Washington state (USA) in 1996 and initially radiocarbon dated to 8,340-9,200 calibrated years before present (BP). His population affinities have been the subject of scientific debate and legal controversy. Based on an initial study of cranial morphology it was asserted that Kennewick Man was neither Native American nor closely related to the claimant Plateau tribes of the Pacific Northwest, who claimed ancestral relationship and requested repatriation under the Native American Graves Protection and Repatriation Act (NAGPRA). The morphological analysis was important to judicial decisions that Kennewick Man was not Native American and that therefore NAGPRA did not apply. Instead of repatriation, additional studies of the remains were permitted. Subsequent craniometric analysis affirmed Kennewick Man to be more closely related to circumpacific groups such as the Ainu and Polynesians than he is to modern Native Americans. In order to resolve Kennewick Man's ancestry and affiliations, we have sequenced his genome to ∼1× coverage and compared it to worldwide genomic data including for the Ainu and Polynesians. We find that Kennewick Man is closer to modern Native Americans than to any other population worldwide. Among the Native American groups for whom genome-wide data are available for comparison, several seem to be descended from a population closely related to that of Kennewick Man, including the Confederated Tribes of the Colville Reservation (Colville), one of the five tribes claiming Kennewick Man. We revisit the cranial analyses and find that, as opposed to genome-wide comparisons, it is not possible on that basis to affiliate Kennewick Man to specific contemporary groups. We therefore conclude based on genetic comparisons that Kennewick Man shows continuity with Native North Americans over at least the last eight millennia.

  13. EXO-DAT: AN INFORMATION SYSTEM IN SUPPORT OF THE CoRoT/EXOPLANET SCIENCE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Deleuil, M.; Meunier, J. C.; Moutou, C.

    2009-08-15

    Exo-Dat is a database and an information system created primarily in support of the exoplanet program of the COnvection ROtation and planetary Transits (CoRoT) mission. In the directions of CoRoT pointings, it provides a united interface to several sets of data: stellar published catalogs, photometric and spectroscopic data obtained during the mission preparation, results from the mission and from follow-up observations, and several mission-specific technical parameters. The new photometric data constitute the subcatalog Exo-Cat, and give consistent 4-color photometry of 14.0 million stars with a completeness to 19th magnitude in the r-filter. It covers several zones in the galactic planemore » around CoRoT pointings, with a total area of 209 deg{sup 2}. This Exo-Dat information system provides essential technical support to the ongoing CoRoT light-curve analyses and ground-based follow-up by supplying additional complementary information such as the prior knowledge of the star's fundamental parameters or its contamination level inside the large CoRoT photometric mask. The database is fully interfaced with VO tools and thus benefits from existing visualization and analysis tools like TOPCAT or ALADIN. It is accessible to the CoRoT community through the Web, and will be gradually opened to the public. It is the ideal tool to prepare the foreseen statistical studies of the properties of the exoplanetary systems. As a VO-compliant system, such analyses could thus benefit from the most up-to-date classifier tools.« less

  14. [Epidermic chalone receptors in psoriasis treated with retinoid:Ro 10-9359].

    PubMed

    Vignale, R A; Lasalvia, E; Espasandín, J; Borras, A

    1983-01-01

    The epidermic chalone receptor of skin with lesion and without lesion are studied on 20 patients with active psoriasis. The testlest were performed before and two month after oral treatment with RO 10-9359. Roche. The results show significant variation with an increased a the number of receptors after treatment. As these receptors are in the cell membrane, the authors consider that RO 10-9359 action in on the membrane and its surrounding, making in possible to the epithelial cell to begin its autoregulation, autocontrol and differentiation when the specific activity of the chalones become normal.

  15. 33 CFR 143.407 - Manning.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Manning. 143.407 Section 143.407 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Standby Vessels § 143.407 Manning. Standby vessels must be crewed...

  16. 33 CFR 143.407 - Manning.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Manning. 143.407 Section 143.407 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Standby Vessels § 143.407 Manning. Standby vessels must be crewed...

  17. 33 CFR 143.407 - Manning.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Manning. 143.407 Section 143.407 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Standby Vessels § 143.407 Manning. Standby vessels must be crewed...

  18. 33 CFR 143.407 - Manning.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Manning. 143.407 Section 143.407 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Standby Vessels § 143.407 Manning. Standby vessels must be crewed...

  19. History of Manned Space Flight

    NASA Technical Reports Server (NTRS)

    1975-01-01

    U.S. manned space projects from Mercury Redstone 3 through Skylab 4 are briefly described including dates, flight duration, crew, and number of earth/moon orbits. The flight costs of each project are itemized. Highlights in the history of the manned space program from 1957 to February, 1974 are included.

  20. AmeriFlux US-Ro3 Rosemount- G19

    DOE Data Explorer

    Baker, John [USDA-ARS; Griffis, Tim [University of Minnesota

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-Ro3 Rosemount- G19. Site Description - This tower is located in a farm field farmed in accordance with the cominant farming practice in the region: a corn/soybean rotation with chisel plow tillage in the fall following corn harvest and in the spring following soybeans.

  1. AmeriFlux US-Ro1 Rosemount- G21

    DOE Data Explorer

    Baker, John [USDA-ARS; Griffis, Tim [University of Minnesota; Griffis, Timothy [University of Minnesota

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-Ro1 Rosemount- G21. Site Description - This tower is located in a farm field farmed in accordance with the dominant farming practice in the region: a corn/soybean rotation with chisel plow tillage in the fall following corn harvest and in the spring following soybeans.

  2. AmeriFlux US-Ro2 Rosemount- C7

    DOE Data Explorer

    Baker, John [USDA-ARS; Griffis, Tim [University of Minnesota

    2018-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-Ro2 Rosemount- C7. Site Description - This tower is located in a farm field farmed in accordance with the dominant farming practice in the region: a corn/soybean/clover rotation with chisel plow tillage in the fall following corn harvest and in the spring following soybeans.

  3. Characterisation of residual ionospheric errors in bending angles using GNSS RO end-to-end simulations

    NASA Astrophysics Data System (ADS)

    Liu, C. L.; Kirchengast, G.; Zhang, K. F.; Norman, R.; Li, Y.; Zhang, S. C.; Carter, B.; Fritzer, J.; Schwaerz, M.; Choy, S. L.; Wu, S. Q.; Tan, Z. X.

    2013-09-01

    Global Navigation Satellite System (GNSS) radio occultation (RO) is an innovative meteorological remote sensing technique for measuring atmospheric parameters such as refractivity, temperature, water vapour and pressure for the improvement of numerical weather prediction (NWP) and global climate monitoring (GCM). GNSS RO has many unique characteristics including global coverage, long-term stability of observations, as well as high accuracy and high vertical resolution of the derived atmospheric profiles. One of the main error sources in GNSS RO observations that significantly affect the accuracy of the derived atmospheric parameters in the stratosphere is the ionospheric error. In order to mitigate the effect of this error, the linear ionospheric correction approach for dual-frequency GNSS RO observations is commonly used. However, the residual ionospheric errors (RIEs) can be still significant, especially when large ionospheric disturbances occur and prevail such as during the periods of active space weather. In this study, the RIEs were investigated under different local time, propagation direction and solar activity conditions and their effects on RO bending angles are characterised using end-to-end simulations. A three-step simulation study was designed to investigate the characteristics of the RIEs through comparing the bending angles with and without the effects of the RIEs. This research forms an important step forward in improving the accuracy of the atmospheric profiles derived from the GNSS RO technique.

  4. Man-Amplifying Exoskeleton

    NASA Astrophysics Data System (ADS)

    Rosheim, Mark E.

    1990-03-01

    This paper describes a design for a man-amplifying exoskeleton, an electrically powered, articulated frame worn by an operator. The design features modular construction and employ anthropomorphic pitch-yaw joints for arms and legs. These singularity-free designs offer a significant advancement over simple pivot-type joints used in older designs. Twenty-six degrees-of-freedom excluding the hands gives the Man-Amplifier its unique dexterity. A five hundred-pound load capacity is engineered for a diverse range of tasks. Potential applications in emergency rescue work, restoring functionality to the handicapped, and military applications ranging from material handling to an elite fighting core are discussed. A bibliography concludes this paper.

  5. Rotating single-shot acquisition (RoSA) with composite reconstruction for fast high-resolution diffusion imaging.

    PubMed

    Wen, Qiuting; Kodiweera, Chandana; Dale, Brian M; Shivraman, Giri; Wu, Yu-Chien

    2018-01-01

    To accelerate high-resolution diffusion imaging, rotating single-shot acquisition (RoSA) with composite reconstruction is proposed. Acceleration was achieved by acquiring only one rotating single-shot blade per diffusion direction, and high-resolution diffusion-weighted (DW) images were reconstructed by using similarities of neighboring DW images. A parallel imaging technique was implemented in RoSA to further improve the image quality and acquisition speed. RoSA performance was evaluated by simulation and human experiments. A brain tensor phantom was developed to determine an optimal blade size and rotation angle by considering similarity in DW images, off-resonance effects, and k-space coverage. With the optimal parameters, RoSA MR pulse sequence and reconstruction algorithm were developed to acquire human brain data. For comparison, multishot echo planar imaging (EPI) and conventional single-shot EPI sequences were performed with matched scan time, resolution, field of view, and diffusion directions. The simulation indicated an optimal blade size of 48 × 256 and a 30 ° rotation angle. For 1 × 1 mm 2 in-plane resolution, RoSA was 12 times faster than the multishot acquisition with comparable image quality. With the same acquisition time as SS-EPI, RoSA provided superior image quality and minimum geometric distortion. RoSA offers fast, high-quality, high-resolution diffusion images. The composite image reconstruction is model-free and compatible with various diffusion computation approaches including parametric and nonparametric analyses. Magn Reson Med 79:264-275, 2018. © 2017 International Society for Magnetic Resonance in Medicine. © 2017 International Society for Magnetic Resonance in Medicine.

  6. Man Machine Systems in Education.

    ERIC Educational Resources Information Center

    Sall, Malkit S.

    This review of the research literature on the interaction between humans and computers discusses how man machine systems can be utilized effectively in the learning-teaching process, especially in secondary education. Beginning with a definition of man machine systems and comments on the poor quality of much of the computer-based learning material…

  7. 32 CFR 707.2 - Man overboard lights.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Man overboard lights. 707.2 Section 707.2... RESPECT TO ADDITIONAL STATION AND SIGNAL LIGHTS § 707.2 Man overboard lights. Naval vessels may display, as a means of indicating man overboard, two pulsating, all round red lights in the vertical line...

  8. 32 CFR 707.2 - Man overboard lights.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false Man overboard lights. 707.2 Section 707.2... RESPECT TO ADDITIONAL STATION AND SIGNAL LIGHTS § 707.2 Man overboard lights. Naval vessels may display, as a means of indicating man overboard, two pulsating, all round red lights in the vertical line...

  9. 32 CFR 707.2 - Man overboard lights.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 5 2014-07-01 2014-07-01 false Man overboard lights. 707.2 Section 707.2... RESPECT TO ADDITIONAL STATION AND SIGNAL LIGHTS § 707.2 Man overboard lights. Naval vessels may display, as a means of indicating man overboard, two pulsating, all round red lights in the vertical line...

  10. 32 CFR 707.2 - Man overboard lights.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Man overboard lights. 707.2 Section 707.2... RESPECT TO ADDITIONAL STATION AND SIGNAL LIGHTS § 707.2 Man overboard lights. Naval vessels may display, as a means of indicating man overboard, two pulsating, all round red lights in the vertical line...

  11. Soils: man-caused radioactivity and radiation forecast

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gablin, Vassily

    2007-07-01

    Available in abstract form only. Full text of publication follows: One of the main tasks of the radiation safety guarantee is non-admission of the excess over critical radiation levels. In Russia they are man-caused radiation levels. Meanwhile any radiation measurement represents total radioactivity. That is why it is hard to assess natural and man-caused contributions to total radioactivity. It is shown that soil radioactivity depends on natural factors including radioactivity of rocks and cosmic radiation as well as man-caused factors including nuclear and non-nuclear technologies. Whole totality of these factors includes unpredictable (non-deterministic) factors - nuclear explosions and radiation accidents,more » and predictable ones (deterministic) - all the rest. Deterministic factors represent background radioactivity whose trends is the base of the radiation forecast. Non-deterministic factors represent man-caused radiation treatment contribution which is to be controlled. This contribution is equal to the difference in measured radioactivity and radiation background. The way of calculation of background radioactivity is proposed. Contemporary soils are complicated technologically influenced systems with multi-leveled spatial and temporary inhomogeneity of radionuclides distribution. Generally analysis area can be characterized by any set of factors of soil radioactivity including natural and man-caused factors. Natural factors are cosmic radiation and radioactivity of rocks. Man-caused factors are shown on Fig. 1. It is obvious that man-caused radioactivity is due to both artificial and natural emitters. Any result of radiation measurement represents total radioactivity i.e. the sum of activities resulting from natural and man-caused emitters. There is no gauge which could separately measure natural and man-caused radioactivity. That is why it is so hard to assess natural and man-caused contributions to soil radioactivity. It would have been possible if

  12. 33 CFR 143.407 - Manning.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Manning. 143.407 Section 143.407 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Standby Vessels § 143.407 Manning. Standby vessels must be crewed in accordance with their certificate o...

  13. 29 CFR 780.305 - 500 man-day provision.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false 500 man-day provision. 780.305 Section 780.305 Labor...) Statutory Provisions § 780.305 500 man-day provision. (a) Section 3(u) of the Act defines man-day to mean “any day during which an employee performs agricultural labor for not less than 1 hour.” 500 man-days...

  14. 29 CFR 780.305 - 500 man-day provision.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false 500 man-day provision. 780.305 Section 780.305 Labor...) Statutory Provisions § 780.305 500 man-day provision. (a) Section 3(u) of the Act defines man-day to mean “any day during which an employee performs agricultural labor for not less than 1 hour.” 500 man-days...

  15. 29 CFR 780.305 - 500 man-day provision.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false 500 man-day provision. 780.305 Section 780.305 Labor...) Statutory Provisions § 780.305 500 man-day provision. (a) Section 3(u) of the Act defines man-day to mean “any day during which an employee performs agricultural labor for not less than 1 hour.” 500 man-days...

  16. 29 CFR 780.305 - 500 man-day provision.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false 500 man-day provision. 780.305 Section 780.305 Labor...) Statutory Provisions § 780.305 500 man-day provision. (a) Section 3(u) of the Act defines man-day to mean “any day during which an employee performs agricultural labor for not less than 1 hour.” 500 man-days...

  17. Rapid-Adiabatic Control of Ro-Vibrational Populations in Polyatomic Molecules

    NASA Astrophysics Data System (ADS)

    Zak, Emil J.; Yachmenev, Andrey

    2017-06-01

    We present a simple method for control of ro-vibrational populations in polyatomic molecules in the presence of inhomogeneous electric fields [1]. Cooling and trapping of heavy polar polyatomic molecules has become one of the frontier goals in high-resolution molecular spectroscopy, especially in the context of parity violation measurement in chiral compounds [2]. A key step toward reaching this goal would be development of a robust and efficient protocol for control of populations of ro-vibrational states in polyatomic, often floppy molecules. Here we demonstrate a modification of the stark-chirped rapid-adiabatic-passage technique (SCRAP) [3], designed for achieving high levels of control of ro-vibrational populations over a selected region in space. The new method employs inhomogeneous electric fields to generate space- and time- controlled Stark-shifts of energy levels in molecules. Adiabatic passage between ro-vibrational states is enabled by the pump pulse, which raises the value of the Rabi frequency. This Stark-chirped population transfer can be used in manipulation of population differences between high-field-seeking and low-field-seeking states of molecules in the Stark decelerator [4]. Appropriate timing of voltages on electric rods located along the decelerator combined with a single pump laser renders our method as potentially more efficient than traditional Stark decelerator techniques. Simulations for NH_3 show significant improvement in effectiveness of cooling, with respect to the standard 'moving-potential' method [5]. At the same time a high phase-space acceptance of the molecular packet is maintained. E. J. Zak, A. Yachmenev (submitted). C. Medcraft, R. Wolf, M. Schnell, Angew. Chem. Int. Ed., 53, 43, 11656-11659 (2014) M. Oberst, H. Munch, T. Halfman, PRL 99, 173001 (2007). K. Wohlfart, F. Grätz, F. Filsinger, H. Haak, G. Meijer, J. Küpper, Phys. Rev. A 77, 031404(R) (2008). H. L. Bethlem, F. M. H. Crompvoets, R. T. Jongma, S. Y. T. van de

  18. 29 CFR 780.309 - Man-day exclusion.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Man-day exclusion. 780.309 Section 780.309 Labor...) Statutory Provisions § 780.309 Man-day exclusion. Section 3(e)(1) specifically excludes from the employer's man-day total (as defined in section 3(u)) employees who qualify for exemption under section 13(a)(6...

  19. 29 CFR 780.317 - Man-day exclusion.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Man-day exclusion. 780.317 Section 780.317 Labor...) Statutory Provisions § 780.317 Man-day exclusion. Section 3(e)(2) specifically excludes from the employer's man-day total (as defined in section 3(u)) employees who qualify for exemption under section 13(a)(6...

  20. 29 CFR 780.317 - Man-day exclusion.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Man-day exclusion. 780.317 Section 780.317 Labor...) Statutory Provisions § 780.317 Man-day exclusion. Section 3(e)(2) specifically excludes from the employer's man-day total (as defined in section 3(u)) employees who qualify for exemption under section 13(a)(6...

  1. 29 CFR 780.317 - Man-day exclusion.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Man-day exclusion. 780.317 Section 780.317 Labor...) Statutory Provisions § 780.317 Man-day exclusion. Section 3(e)(2) specifically excludes from the employer's man-day total (as defined in section 3(u)) employees who qualify for exemption under section 13(a)(6...

  2. 29 CFR 780.309 - Man-day exclusion.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Man-day exclusion. 780.309 Section 780.309 Labor...) Statutory Provisions § 780.309 Man-day exclusion. Section 3(e)(1) specifically excludes from the employer's man-day total (as defined in section 3(u)) employees who qualify for exemption under section 13(a)(6...

  3. 29 CFR 780.309 - Man-day exclusion.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Man-day exclusion. 780.309 Section 780.309 Labor...) Statutory Provisions § 780.309 Man-day exclusion. Section 3(e)(1) specifically excludes from the employer's man-day total (as defined in section 3(u)) employees who qualify for exemption under section 13(a)(6...

  4. 29 CFR 780.317 - Man-day exclusion.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Man-day exclusion. 780.317 Section 780.317 Labor...) Statutory Provisions § 780.317 Man-day exclusion. Section 3(e)(2) specifically excludes from the employer's man-day total (as defined in section 3(u)) employees who qualify for exemption under section 13(a)(6...

  5. 29 CFR 780.309 - Man-day exclusion.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Man-day exclusion. 780.309 Section 780.309 Labor...) Statutory Provisions § 780.309 Man-day exclusion. Section 3(e)(1) specifically excludes from the employer's man-day total (as defined in section 3(u)) employees who qualify for exemption under section 13(a)(6...

  6. Old man-young man: T.S. Eliot's Gerontion and the problem of identity.

    PubMed

    Wigand, Moritz E; Wiegand, Hauke F; Jäger, Markus; Becker, Thomas

    2017-03-01

    In his poem Gerontion (1920) Nobel laureate T.S. Eliot uses powerful language to give a fictional, highly condensed, first-person account of medical and psychological conditions that arise with old age: physical frailty, cognitive decline, sensory impairment, depressive symptoms with embitterment, social withdrawal and the psychological strain of having to face old age and make meaning of one's life. Surprisingly, he wrote the poem as a young man. In this qualitative study, we used a hermeneutic approach to interpret Gerontion from a psychiatric perspective. We considered how Gerontion could help us to further an empathic understanding of these mental states, why a young man expresses himself through the voice of an old man and how the depressed-aggressive tone of the poem with its contempt and anti-Semitism can be interpreted. We concluded that Eliot was grappling with his identity as an American in England, as a sexually inhibited husband to a demanding wife, as a banker and poet and as someone who had witnessed the effects of WWI. Readers of the poem can simultaneously experience the suffering of an old man and the identity crisis of a young man. The poem can thus further insight into the development of contempt and promote empathy and professionalism in dealing with states such as late-life depression. Consequently it is well suited for use in medical classes on these issues, particularly because it is much shorter than a novel or film.

  7. Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species.

    PubMed

    Varty, G B; Hyde, L A; Hodgson, R A; Lu, S X; McCool, M F; Kazdoba, T M; Del Vecchio, R A; Guthrie, D H; Pond, A J; Grzelak, M E; Xu, X; Korfmacher, W A; Tulshian, D; Parker, E M; Higgins, G A

    2005-10-01

    Previous studies have demonstrated behaviors indicative of anxiolysis in rats pretreated with the nociceptin receptor (opioid receptor like-1, ORL-1) agonist, Ro64-6198. The aim of this study was to examine the effects of Ro64-6198 in anxiety models across three species: rat, guinea pig, and mouse. In addition, the receptor specificity of Ro64-6198 was studied, using the ORL-1 receptor antagonist, J-113397, and ORL-1 receptor knockout (KO) mice. Finally, neurological studies examined potential side effects of Ro64-6198 in the rat and mouse. Ro64-6198 (3-10 mg/kg) increased punished responding in a rat conditioned lick suppression test similarly to chlordiazepoxide (6 mg/kg). This effect of Ro64-6198 was attenuated by J-113397 (10 mg/kg), but not the mu opioid antagonist, naltrexone (3 mg/kg). In addition, Ro64-6198 (1-3 mg/kg) reduced isolation-induced vocalizations in rat and guinea pig pups. Ro64-6198 (3 mg/kg) increased the proportion of punished responding in a mouse Geller-Seifter test in wild-type (WT) but not ORL-1 KO mice, whereas diazepam (1-5.6 mg/kg) was effective in both genotypes. In rats, Ro64-6198 reduced locomotor activity (LMA) and body temperature and impaired rotarod, beam walking, and fixed-ratio (FR) performance at doses of 10-30 mg/kg, i.e., three to ten times higher than an anxiolytic dose. In WT mice, Ro64-6198 (3-10 mg/kg) reduced LMA and rotarod performance, body temperature, and FR responding, but these same measures were unaffected in ORL-1 KO mice. Haloperidol (0.3-3 mg/kg) reduced these measures to a similar extent in both genotypes. These studies confirm the potent, ORL-1 receptor-mediated, anxiolytic-like effects of Ro64-6198, extending the findings across three species. Ro64-6198 has target-based side effects, although the magnitude of these effects varies across species.

  8. The most interesting roAp target for MONS: HR1217 ?

    NASA Astrophysics Data System (ADS)

    Knudsen, M. R.

    2000-04-01

    The roAp star HR1217 is presented as a good and possibly the best roAp target for MONS and the progress of the 1998 3-site STACC Campaign is briefly summarized incl. the first detection of EW oscillation in Hα and Hβ in this star, alongside evidence of EW varying with the phase of rotation. HR1217 has 6 known oscillation frequencies of which the four strongest appear to be rotationally split with photometric amplitudes ~< 1 mmag. The problem with groundbased observations is the 3-day-alias beating with neighbouring peaks which limits our chances for a solid mode id. With 30 days (2.4ṡ Prot) on MONS CAM we should have the needed observational data for doing asteroseismology on a magnetic star at last!

  9. Man in a Changing World.

    ERIC Educational Resources Information Center

    Fairfax County Schools, VA.

    The sixth level of the social studies curriculum (Fairfax County Public Schools, Virginia), "Man in a Changing World," is designed to maintain a balance between the study of concepts and the development of inquiry skills. Emphasis is given to the role of individual man in several social settings, past and present, Western and non-Western. The…

  10. Dispersion and nonlinear effects in OFDM-RoF system

    NASA Astrophysics Data System (ADS)

    Alhasson, Bader H.; Bloul, Albe M.; Matin, M.

    2010-08-01

    The radio-over-fiber (RoF) network has been a proven technology to be the best candidate for the wireless-access technology, and the orthogonal frequency division multiplexing (OFDM) technique has been established as the core technology in the physical layer of next generation wireless communication system, as a result OFDM-RoF has drawn attentions worldwide and raised many new research topics recently. At the present time, the trend of information industry is towards mobile, wireless, digital and broadband. The next generation network (NGN) has motivated researchers to study higher-speed wider-band multimedia communication to transmit (voice, data, and all sorts of media such as video) at a higher speed. The NGN would offer services that would necessitate broadband networks with bandwidth higher than 2Mbit/s per radio channel. Many new services emerged, such as Internet Protocol TV (IPTV), High Definition TV (HDTV), mobile multimedia and video stream media. Both speed and capacity have been the key objectives in transmission. In the meantime, the demand for transmission bandwidth increased at a very quick pace. The coming of 4G and 5G era will provide faster data transmission and higher bit rate and bandwidth. Taking advantages of both optical communication and wireless communication, OFDM Radio over Fiber (OFDM-RoF) system is characterized by its high speed, large capacity and high spectral efficiency. However, up to the present there are some problems to be solved, such as dispersion and nonlinearity effects. In this paper we will study the dispersion and nonlinearity effects and their elimination in OFDM-radio-over-fiber system.

  11. 32 CFR 707.2 - Man overboard lights.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Man overboard lights. 707.2 Section 707.2 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY NAVIGATION SPECIAL RULES WITH RESPECT TO ADDITIONAL STATION AND SIGNAL LIGHTS § 707.2 Man overboard lights. Naval vessels may display, as a means of indicating man overboard, two...

  12. Symbolism in prehistoric man.

    PubMed

    Facchini, F

    2000-12-01

    The aptitude for symbolization, characteristic of man, is revealed not only in artistic representations and funerary practices. It is exhibited by every manifestation of human activity or representation of natural phenomena that assumes or refers to a meaning. We can recognize functional symbolism (tool-making, habitative or food technology), social symbolism, (language and social communication) and spiritual symbolism (funerary practices and artistic expressions). On the basis of these concepts, research into symbolism in prehistoric man allows us to recognize forms of symbolism already in the manifestations of the most ancient humans, starting with Homo habilis (or rudolfensis). Toolmaking, social organization and organization of the territory are oriented toward survival and the life of the family group. They attest to symbolic behaviors and constitute symbolic systems by means of which man expresses himself, lives and transmits his symbolic world. The diverse forms of symbolism are discussed with reference to the different phases of prehistoric humanity.

  13. Mannans and endo-β-mannanases (MAN) in Brachypodium distachyon: expression profiling and possible role of the BdMAN genes during coleorhiza-limited seed germination

    PubMed Central

    González-Calle, Virginia; Barrero-Sicilia, Cristina; Carbonero, Pilar; Iglesias-Fernández, Raquel

    2015-01-01

    Immunolocalization of mannans in the seeds of Brachypodium distachyon reveals the presence of these polysaccharides in the root embryo and in the coleorhiza in the early stages of germination (12h), decreasing thereafter to the point of being hardly detected at 27h. Concurrently, the activity of endo-β-mannanases (MANs; EC 3.2.1.78) that catalyse the hydrolysis of β-1,4 bonds in mannan polymers, increases as germination progresses. The MAN gene family is represented by six members in the Brachypodium genome, and their expression has been explored in different organs and especially in germinating seeds. Transcripts of BdMAN2, BdMAN4 and BdMAN6 accumulate in embryos, with a maximum at 24–30h, and are detected in the coleorhiza and in the root by in situ hybridization analyses, before root protrusion (germination sensu stricto). BdMAN4 is not only present in the embryo root and coleorhiza, but is abundant in the de-embryonated (endosperm) imbibed seeds, while BdMAN2 and BdMAN6 are faintly expressed in endosperm during post-germination (36–42h). BdMAN4 and BdMAN6 transcripts are detected in the aleurone layer. These data indicate that BdMAN2, BdMAN4 and BdMAN6 are important for germination sensu stricto and that BdMAN4 and BdMAN6 may also influence reserve mobilization. Whether the coleorhiza in monocots and the micropylar endosperm in eudicots have similar functions, is discussed. PMID:25922488

  14. TU-CD-BRD-00: Incident Learning / RO-ILS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    2015-06-15

    It has long been standard practice in radiation oncology to report internally when a patient’s treatment has not gone as planned and to report events to regulatory agencies when legally required. Most potential errors are caught early and never affect the patient. Quality assurance steps routinely prevent errors from reaching the patient, and these “near misses” are much more frequent than treatment errors. A growing number of radiation oncology facilities have implemented incident learning systems to report and analyze both errors and near misses. Using the term “incident learning” instead of “event reporting” emphasizes the need to use these experiencesmore » to change the practice and make future errors less likely and promote an educational, non-punitive environment. There are challenges in making such a system practical and effective. Speakers from institutions of different sizes and practice environments will share their experiences on how to make such a system work and what benefits their clinics have accrued. Questions that will be addressed include: How to create a system that is easy for front line staff to access How to motivate staff to report How to promote the system as positive and educational and not punitive or demeaning How to organize the team for reviewing and responding to reports How to prioritize which reports to discuss in depth How not to dismiss the rest How to identify underlying causes How to design corrective actions and implement change How to develop useful statistics and analysis tools How to coordinate a departmental system with a larger risk management system How to do this without a dedicated quality manager Some speakers’ experience is with in-house systems and some will share experience with the AAPM/ASTRO national Radiation Oncology Incident Learning System (RO-ILS). Reports intended to be of value nationally need to be comprehensible to outsiders; examples of useful reports will be shown. There will be ample

  15. Translations on North Korea, Number 537

    DTIC Science & Technology

    1977-07-05

    Kim Yong -chu, then director of the party’s agitprop department. In the second half of the 1960’s he was named director of the culture and...that he became widely known. At the 7th plenum of the Central Committee, Ch’oe Yong -kin and Kim II proposed Kim Chong-il as the successor to Kim Il...visit of the NCNA delegation were the following: Kim Yong -nam Kim Song-köl Kim Si-hak Kim Yong -sun Ch’ae Chun-pyong Chong

  16. Ro52 autoantibodies arise from self-reactive progenitors in a mother of a child with neonatal lupus.

    PubMed

    Reed, Joanne H; Gorny, Miroslaw K; Li, Liuzhe; Cardozo, Timothy; Buyon, Jill P; Clancy, Robert M

    2017-05-01

    The detection of cardiac conduction defects in an 18-24 week old foetus in the absence of structural abnormalities predicts with near certainty the presence of autoantibodies against 60kD and 52kD SSA/Ro in the mother regardless of her health status. Previous studies have emphasized these autoantibodies as key mediators of tissue injury. The aim of this study was to focus on the anti-Ro52 response to determine whether these autoantibodies originate from progenitors that are inherently self-reactive or from B-cells that acquire self-reactivity during an immune response. We traced the evolution of two anti-Ro52 autoantibodies isolated from circulating IgG1-switched B-cells from an asymptomatic mother of a child with third degree congenital heart block. The autoantibodies were expressed as their immune form and as pre-immune ancestors by reverting somatic mutations to germline sequence. The reactivity of pre-immune and immune antibodies for Ro52, Ro60, La and DNA was measured. Both anti-Ro52 autoantibodies exhibited a low frequency of somatic mutations (3-4%) and utilised the same heavy and light chain genes but represented distinct clones based on differing complementarity determining region sequences. Pre- and post-immune antibodies showed specific binding to Ro52 with no measurable reactivity for other autoantigens. Ro52 binding was higher for immune antibodies compared to pre-immune counterparts demonstrating that autoreactivity was enhanced by affinity maturation. These data indicate that Ro52 reactivity is an intrinsic property of the germline antibody repertoire in a mother with a pathogenic antibody defined by cardiac injury in her offspring, and implies defects in both central and peripheral tolerance mechanisms. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. UF/RO applications at the Browns Ferry Nuclear Power Station

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Palino, G.F.; Sailor, W.C.; Sawochka, S.G.

    1981-04-01

    In June 1979, NWT was contracted by TVA to review the applicability of reverse osmosis (RO) and ultrafiltration (UF) membrane treatment technology at the Browns Ferry Nuclear Power Station. Specific program tasks are described and results presented.

  18. VizieR Online Data Catalog: Algorithm for correcting CoRoT raw light curves (Mislis+, 2010)

    NASA Astrophysics Data System (ADS)

    Mislis, D.; Schmitt, J. H. M. M.; Carone, L.; Guenther, E. W.; Patzold, M.

    2010-10-01

    Requirements : gfortran (or g77, ifort) compiler Input Files : The input files sould be raw CoRoT txt files (http://idoc-corot.ias.u-psud.fr/index.jsp) with names CoRoT*.txt Run the cda by typing C>: ./cda.csh (code and data sould be in the same directory) Output files : CDA creates one ascii output file with name - CoRoT*.R.cor for R filter (2 data files).

  19. The pedagogical value of a student-run community-based experiential learning project: The Yong Loo Lin School of Medicine Public Health Screening.

    PubMed

    Wee, Liang En; Yeo, Wei Xin; Tay, Clifton M; Lee, Jeannette J M; Koh, Gerald C H

    2010-09-01

    We assessed the pedagogical value of a student-led community-based experiential learning project called the Public Health Screening (PHS) run by medical and nursing students of the National University of Singapore's Yong Loo Lin School of Medicine (NUS YLLSoM). We conducted a cross-sectional study using a self-administered anonymised questionnaire on medical and nursing students who participated in PHS using the Fund for the Improvement of Postsecondary Education (FIPSE) Survey Instrument. Participants also gave an overall score for their learning experience at the PHS. The participation rate was 93.1% (576/619) for medical students and 100% (37/37) for nursing students. All participants gave the PHS learning experience a high rating (median = 8 out of maximum of 10, inter-quartile range, 7 to 9). A majority of participants felt that PHS had helped them to improve across all domains surveyed. For medical students, those in preclinical years and females were independently more likely to feel that PHS had helped them to improve in communication skills, teamwork, ability to identify social issues, taking action, and gaining and applying their knowledge than those in clinical years and males. Improved ability to interact with patients (β=1.64, 95%CI, 1.01-2.27), appreciation of challenges to healthcare faced by Singaporeans from lower income groups (β=0.93, 95%CI, 0.49-1.37), thinking of others (β=0.70, 95%CI, 0.04-1.37) and tolerance of different people (β =0.63, 95%CI, 0.17-1.10) were strongly associated with the overall rating score. PHS was a positive learning experience in a wide range of domains for all students involved. This suggests that student-organised community-based experiential learning projects have potential educational value for both medical and nursing students.

  20. A Technological Determinist Viewpoint of the Stanton-Staggers Conflict over "The Selling of the Pentagon": Print Man Versus Electronic Man.

    ERIC Educational Resources Information Center

    Breen, Myles P.

    Media, specifically documentary films on television, profoundly affect both social structure and man's psychological percepts. The clash of views depicted is between "print man" (using U.S. Representative Harley Staggers as an example) and "electronic man" (portrayed as Frank Stanton of CBS) centering on Stagger's objections to…

  1. Results of a customer-based, post-market surveillance survey of the HeRO access device.

    PubMed

    Fusselman, Maureen

    2010-08-01

    In order to supplement post-market surveillance data on the HeRO vascular access device, a non-scientific customer survey was conducted to obtain quantitative data from dialysis providers caring for patients implanted with the device. Dialysis nurses involved in the care of HeRO patients were contacted in order to obtain post-implant device performance information for 10% of patients implanted with the device at the time of the survey. Thirty-eight dialysis units with a total of 65 HeRO patients participated in the survey. The total duration of HeRO device use was 348.4 months with an average use of 5.4 months. Thirty-eight of the 65 HeRO patients (58.5%) were reported to not have experienced any performance issues. There were 28 device performance incidents reported for the remaining 27 patients included in the survey. Occlusion was the single most commonly reported device-related performance issue with 18 patients (27.7%) experiencing 25 occlusive episodes. The majority of the patients who had an occlusion (66.7%) only experienced one occlusive event. Infections occurred in 4 patients (6.2%) with an overall infection rate of 0.38 per 1,000 patient days. Post-market clinical experience during the first 18 months of commercialization of the HeRO device were in line with expectations based on the results from initial clinical studies with the device. Device occlusion remains the most commonly reported performance issue with the reported rate in this survey less than that which was reported in earlier published studies with the device.

  2. 46 CFR 15.525 - Additional manning requirements for tank vessels.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Additional manning requirements for tank vessels. 15.525... MANNING REQUIREMENTS Manning Requirements; Inspected Vessels § 15.525 Additional manning requirements for tank vessels. Parts 31 and 35 of this chapter contain additional manning requirements applicable to...

  3. Human capabilities in space. [man machine interaction

    NASA Technical Reports Server (NTRS)

    Nicogossian, A. E.

    1984-01-01

    Man's ability to live and perform useful work in space was demonstrated throughout the history of manned space flight. Current planning envisions a multi-functional space station. Man's unique abilities to respond to the unforeseen and to operate at a level of complexity exceeding any reasonable amount of previous planning distinguish him from present day machines. His limitations, however, include his inherent inability to survive without protection, his limited strength, and his propensity to make mistakes when performing repetitive and monotonous tasks. By contrast, an automated system does routine and delicate tasks, exerts force smoothly and precisely, stores, and recalls large amounts of data, and performs deductive reasoning while maintaining a relative insensitivity to the environment. The establishment of a permanent presence of man in space demands that man and machines be appropriately combined in spaceborne systems. To achieve this optimal combination, research is needed in such diverse fields as artificial intelligence, robotics, behavioral psychology, economics, and human factors engineering.

  4. Surface display of roGFP for monitoring redox status of extracellular microenvironments in Shewanella oneidensis biofilms.

    PubMed

    Sivakumar, Krishnakumar; Mukherjee, Manisha; Cheng, Hsin-I; Zhang, Yingdan; Ji, Lianghui; Cao, Bin

    2015-03-01

    Biofilms are the most ubiquitous and resilient form of microbial life on earth. One most important feature of a biofilm is the presence of a self-produced matrix, which creates highly heterogeneous and dynamic microenvironments within biofilms. Redox status in biofilm microenvironments plays a critical role in biofilm development and function. However, there is a lack of non-intrusive tools to quantify extracellular redox status of microenvironments within a biofilm matrix. In this study, using Shewanella oneidensis as a model organism, we demonstrated a novel approach to monitor extracellular redox status in biofilm microenvironments. Specifically, we displayed a redox sensitive fluorescence protein roGFP onto the cell surface of S. oneidensis by fusing it to the C-terminus of BpfA, a large surface protein, and used the surface displayed roGFP as a sensor to quantify the extracellular redox status in the matrix of S. oneidensis biofilms. The fusion of roGFP into BpfA has no negative impacts on cell growth and biofilm formation. Upon exposure to oxidizing agents such as H2 O2 , Ag(+) , and SeO3 (2-) , S. oneidensis BpfA-roGFP cells exhibited a characteristic fluorescence of roGFP. Proteinase treatment assay and super-resolution structured illumination microscopy confirmed the surface localization of BpfA-roGFP. We further used the surface displayed roGFP monitored the extracellular redox status in the matrix at different depths of a biofilm exposed to H2 O2 . This study provides a novel approach to non-invasively monitor extracellular redox status in microenvironments within biofilms, which can be used to understand redox responses of biofilms to environmental perturbations. © 2014 Wiley Periodicals, Inc.

  5. Accretion Product Formation from Self- and Cross-Reactions of RO2 Radicals in the Atmosphere.

    PubMed

    Berndt, Torsten; Scholz, Wiebke; Mentler, Bernhard; Fischer, Lukas; Herrmann, Hartmut; Kulmala, Markku; Hansel, Armin

    2018-03-26

    Hydrocarbons are emitted into the Earth's atmosphere in very large quantities by human and biogenic activities. Their atmospheric oxidation processes almost exclusively yield RO 2 radicals as reactive intermediates whose atmospheric fate is not yet fully unraveled. Herein, we show that gas-phase reactions of two RO 2 radicals produce accretion products composed of the carbon backbone of both reactants. The rates for accretion product formation are very high for RO 2 radicals bearing functional groups, competing with those of the corresponding reactions with NO and HO 2 . This pathway, which has not yet been considered in the modelling of atmospheric processes, can be important, or even dominant, for the fate of RO 2 radicals in all areas of the atmosphere. Moreover, the vapor pressure of the formed accretion products can be remarkably low, characterizing them as an effective source for the secondary organic aerosol. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Cost analysis of the Hemodialysis Reliable Outflow (HeRO) Graft compared to the tunneled dialysis catheter.

    PubMed

    Al Shakarchi, Julien; Inston, Nicholas; Jones, Robert G; Maclaine, Grant; Hollinworth, David

    2016-04-01

    In end-stage renal disease patients with central venous obstruction, who have limited vascular access options, the Hemodialysis Reliable Outflow (HeRO) Graft is a new alternative with a lower incidence of complications and longer effective device life compared to tunneled dialysis catheters (TDCs). We undertook an economic analysis of introducing the HeRO Graft in the UK. A 1-year cost-consequence decision analytic model was developed comparing management with the HeRO Graft to TDCs from the perspective of the National Health Service in England. The model comprises four 3-month cycles during which the vascular access option either remains functional for hemodialysis or fails, patients can experience access-related infection and device thrombosis, and they can also accrue associated costs. Clinical input data were sourced from published studies and unit cost data from National Health Service 2014-15 Reference Costs. In the base case, a 100-patient cohort managed with the HeRO Graft experienced 6 fewer failed devices, 53 fewer access-related infections, and 67 fewer device thromboses compared to patients managed with TDCs. Although the initial device and placement costs for the HeRO Graft are greater than those for TDCs, savings from the lower incidence of device complications and longer effective device patency reduces these costs. Overall net annual costs are £2600 for each HeRO Graft-managed patient compared to TDC-managed patients. If the National Health Service were to reimburse hemodialysis at a uniform rate regardless of the type of vascular access, net 1-year savings of £1200 per patient are estimated for individuals managed with the HeRO Graft. The base case results showed a marginal net positive cost associated with vascular access with the HeRO Graft compared with TDCs for the incremental clinical benefit of reductions in patency failures, device-related thrombosis, and access-related infection events in a patient population with limited options for

  7. QX MAN: Q and X file manipulation

    NASA Technical Reports Server (NTRS)

    Krein, Mark A.

    1992-01-01

    QX MAN is a grid and solution file manipulation program written primarily for the PARC code and the GRIDGEN family of grid generation codes. QX MAN combines many of the features frequently encountered in grid generation, grid refinement, the setting-up of initial conditions, and post processing. QX MAN allows the user to manipulate single block and multi-block grids (and their accompanying solution files) by splitting, concatenating, rotating, translating, re-scaling, and stripping or adding points. In addition, QX MAN can be used to generate an initial solution file for the PARC code. The code was written to provide several formats for input and output in order for it to be useful in a broad spectrum of applications.

  8. 42 CFR 84.99 - Man tests; testing conditions; general requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Man tests; testing conditions; general requirements...-Contained Breathing Apparatus § 84.99 Man tests; testing conditions; general requirements. (a) The man tests...) All man tests will be conducted by the Institute. (d) The apparatus will be examined before each man...

  9. 42 CFR 84.99 - Man tests; testing conditions; general requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Man tests; testing conditions; general requirements...-Contained Breathing Apparatus § 84.99 Man tests; testing conditions; general requirements. (a) The man tests...) All man tests will be conducted by the Institute. (d) The apparatus will be examined before each man...

  10. 42 CFR 84.99 - Man tests; testing conditions; general requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Man tests; testing conditions; general requirements...-Contained Breathing Apparatus § 84.99 Man tests; testing conditions; general requirements. (a) The man tests...) All man tests will be conducted by the Institute. (d) The apparatus will be examined before each man...

  11. 42 CFR 84.99 - Man tests; testing conditions; general requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Man tests; testing conditions; general requirements...-Contained Breathing Apparatus § 84.99 Man tests; testing conditions; general requirements. (a) The man tests...) All man tests will be conducted by the Institute. (d) The apparatus will be examined before each man...

  12. Man-systems distributed system for Space Station Freedom

    NASA Technical Reports Server (NTRS)

    Lewis, J. L.

    1990-01-01

    Viewgraphs on man-systems distributed system for Space Station Freedom are presented. Topics addressed include: description of man-systems (definition, requirements, scope, subsystems, and topologies); implementation (approach, tools); man-systems interfaces (system to element and system to system); prime/supporting development relationship; selected accomplishments; and technical challenges.

  13. 33 CFR 146.120 - Manning of survival craft.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Manning of survival craft. 146.120 Section 146.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.120 Manning of survival...

  14. 33 CFR 146.120 - Manning of survival craft.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Manning of survival craft. 146.120 Section 146.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.120 Manning of survival...

  15. 33 CFR 146.120 - Manning of survival craft.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Manning of survival craft. 146.120 Section 146.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.120 Manning of survival...

  16. 33 CFR 146.120 - Manning of survival craft.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Manning of survival craft. 146.120 Section 146.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.120 Manning of survival...

  17. Typhoon Man-Yi

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Typhoon Man-Yi was pummeling the Japanese island of Okinawa with winds between 230 and 295 kilometers per hour (125-160 knots, 144-184 miles per hour) and heavy rain on the morning of July 13, 2007, when the Moderate Resolution Imaging Spectroradiometer (MODIS) on NASA's Terra satellite captured this image. The immense storm covered hundreds of kilometers with spiraling bands of thunderstorms, though it had lost the distinctive cloud-free eye it exhibited the day before. Typhoons are common in Japan, but powerful typhoons usually strike the island nation later in the year. The Japan Meteorological Agency said that Man-Yi is the fourth typhoon of the 2007 season and may be the most powerful ever observed in the northwest Pacific in July, reported Kyodo News. The Joint Typhoon Warning Center expected the typhoon to strike Kyushu, a southern Japanese island, on July 14, and then curve northeast along the eastern shore of Japan. By the time the storm reaches Tokyo on July 15, it should be degraded to a tropical storm. As of July 13, Typhoon Man-Yi had injured eight and flooded twenty houses in Okinawa, and forced airlines to cancel hundreds of flights, said Kyodo News. The storm was expected to bring heavy rain to Japan's Pacific coast. NASA image created by Jesse Allen, using data provided courtesy of the MODIS Rapid Response team.

  18. THE MAN MADE WORLD, TEACHER'S MANUAL.

    ERIC Educational Resources Information Center

    Commission on Engineering Education, Washington, DC.

    THIS TEACHER'S MANUAL FOR THE ENGINEERING CONCEPTS CURRICULUM PROJECT'S HIGH SCHOOL COURSE, "THE MAN MADE WORLD," IS THE THIRD DRAFT OF THE EXPERIMENTAL VERSION. THE MATERIAL WRITTEN BY ENGINEERS, SCIENTISTS, AND EDUCATORS, EMPHASIZES ENGINEERING--MAN'S APPLICATION OF SCIENTIFIC PRINCIPLES TO THE CONTROL AND UTILIZATION OF HIS ENVIRONMENT.…

  19. Marihuana in Man: Three Years Later

    ERIC Educational Resources Information Center

    Hollister, Leo E.

    1971-01-01

    Reviews three years of research on the effects of marihuana in man. Previously known clinical mental and physical effects have been confirmed. Causes and mechanisms of these effects generally remain undetermined in man and animals. Social implications and long term effects require additional study, although usage appears detrimental. (JM)

  20. Improving Enlisted Fleet Manning

    DTIC Science & Technology

    2014-07-01

    instance, if initial training is 9 months long, the first sea tour would be 51 months long under T+X. • “ 4YO /60”: A 4-year initial obligation and a 60...months Increase student IA BA from 236 to 316 CS Sea manning overage overall and at E-5; sea manning gaps at E-8 and E-9 Stay at 4YO /54 Lengthen...from 4YO /60 to 5YO/60 Shorten first shore tour to 26 months Lengthen second shore tour to 48 months Lengthen third sea tour to 48 months Increase

  1. Reconstruction-of-difference (RoD) imaging for cone-beam CT neuro-angiography

    NASA Astrophysics Data System (ADS)

    Wu, P.; Stayman, J. W.; Mow, M.; Zbijewski, W.; Sisniega, A.; Aygun, N.; Stevens, R.; Foos, D.; Wang, X.; Siewerdsen, J. H.

    2018-06-01

    Timely evaluation of neurovasculature via CT angiography (CTA) is critical to the detection of pathology such as ischemic stroke. Cone-beam CTA (CBCT-A) systems provide potential advantages in the timely use at the point-of-care, although challenges of a relatively slow gantry rotation speed introduce tradeoffs among image quality, data consistency and data sparsity. This work describes and evaluates a new reconstruction-of-difference (RoD) approach that is robust to such challenges. A fast digital simulation framework was developed to test the performance of the RoD over standard reference reconstruction methods such as filtered back-projection (FBP) and penalized likelihood (PL) over a broad range of imaging conditions, grouped into three scenarios to test the trade-off between data consistency, data sparsity and peak contrast. Two experiments were also conducted using a CBCT prototype and an anthropomorphic neurovascular phantom to test the simulation findings in real data. Performance was evaluated primarily in terms of normalized root mean square error (NRMSE) in comparison to truth, with reconstruction parameters chosen to optimize performance in each case to ensure fair comparison. The RoD approach reduced NRMSE in reconstructed images by up to 50%–53% compared to FBP and up to 29%–31% compared to PL for each scenario. Scan protocols well suited to the RoD approach were identified that balance tradeoffs among data consistency, sparsity and peak contrast—for example, a CBCT-A scan with 128 projections acquired in 8.5 s over a 180°  +  fan angle half-scan for a time attenuation curve with ~8.5 s time-to-peak and 600 HU peak contrast. With imaging conditions such as the simulation scenarios of fixed data sparsity (i.e. varying levels of data consistency and peak contrast), the experiments confirmed the reduction of NRMSE by 34% and 17% compared to FBP and PL, respectively. The RoD approach demonstrated superior performance in 3D angiography

  2. 42 CFR 84.102 - Man test 6; requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Man test 6; requirements. 84.102 Section 84.102 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND... Breathing Apparatus § 84.102 Man test 6; requirements. (a) Man test 6 will be conducted with respect to...

  3. 42 CFR 84.102 - Man test 6; requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Man test 6; requirements. 84.102 Section 84.102 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND... Breathing Apparatus § 84.102 Man test 6; requirements. (a) Man test 6 will be conducted with respect to...

  4. 42 CFR 84.102 - Man test 6; requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Man test 6; requirements. 84.102 Section 84.102 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND... Breathing Apparatus § 84.102 Man test 6; requirements. (a) Man test 6 will be conducted with respect to...

  5. 42 CFR 84.102 - Man test 6; requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Man test 6; requirements. 84.102 Section 84.102 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND... Breathing Apparatus § 84.102 Man test 6; requirements. (a) Man test 6 will be conducted with respect to...

  6. AmeriFlux US-Ro5 Rosemount I18_South

    DOE Data Explorer

    Baker, John [USDA-ARS; Griffis, Tim [University of Minnesota

    2018-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-Ro5 Rosemount I18_South. Site Description - This tower is located in a farm field farmed in accordance with the dominant farming practice in the region: a corn/soybean rotation with chisel plow tillage in the fall following corn harvest and in the spring following soybeans.

  7. 33 CFR 146.120 - Manning of survival craft.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Manning of survival craft. 146.120 Section 146.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.120 Manning of survival craft. The owner, the owner's agent, or the...

  8. 42 CFR 84.103 - Man tests; performance requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Man tests; performance requirements. 84.103 Section...-Contained Breathing Apparatus § 84.103 Man tests; performance requirements. (a) The apparatus shall satisfy... is 24 ±6 °C. (75 ±10 °F.), the maximum temperature of inspired air recorded during man tests shall...

  9. 42 CFR 84.103 - Man tests; performance requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Man tests; performance requirements. 84.103 Section...-Contained Breathing Apparatus § 84.103 Man tests; performance requirements. (a) The apparatus shall satisfy... is 24 ±6 °C. (75 ±10 °F.), the maximum temperature of inspired air recorded during man tests shall...

  10. 42 CFR 84.103 - Man tests; performance requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Man tests; performance requirements. 84.103 Section...-Contained Breathing Apparatus § 84.103 Man tests; performance requirements. (a) The apparatus shall satisfy... is 24 ±6 °C. (75 ±10 °F.), the maximum temperature of inspired air recorded during man tests shall...

  11. Water-propellant resistojets for man-tended platforms

    NASA Technical Reports Server (NTRS)

    Louviere, Allen J.; Jones, Robert E.; Morren, W. Earl; Sovey, James S.

    1987-01-01

    The selection of a propulsion system for a man-tended platform has been influenced by the planned use of resistojets for drag make-up on the manned space station. For that application a resistojet has been designed that is capable of operation with a wide variety of propellants, including water. The reasons for the selection of water as the propellant and the performance of water as a propellant are discussed. The man-tended platform and its mission requirements are described.

  12. Song as a Measure of Man

    ERIC Educational Resources Information Center

    Revicki, Robert

    1976-01-01

    This is a reprint of "Song As a Measure of Man," a recent publication by the Fine Arts Program of the Pennsylvania Department of Education. "Song As a Measure of Man" was an outcome of an intensive two-day related arts workshop concerned with "Cantometrics," the first public presentation of Alan Lomax's work in seven…

  13. Manning Army Equal Opportunity Officer Positions

    DTIC Science & Technology

    2013-03-01

    equality , and other social dynamics. This long overdue initiative identified organizational and cultural impediments that had essentially prevented...Manning Army Equal Opportunity Officer Positions by Colonel Angela M. Odom United States Army...TYPE STRATEGY RESEARCH PROJECT .33 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE Manning Army Equal Opportunity Officer Positions 5a

  14. Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus | Center for Cancer Research

    Cancer.gov

    Lupus: No Longer a Lone Wolf. Lupus (represented by the wolf, Canis lupus) is a chronic autoimmune disorder that progresses over decades. Greiling et al. analyzed commensal bacteria in lupus patients and identified species with Ro60 proteins similar to human Ro60, an early autoantigen in lupus. Bacterial Ro60 could activate patient lymphocytes, and colonization of mice with

  15. Hemodialysis Reliable Outflow (HeRO) device in end-stage dialysis access: a decision analysis model.

    PubMed

    Dageforde, Leigh Anne; Bream, Peter R; Moore, Derek E

    2012-09-01

    The Hemodialysis Reliable Outflow (HeRO) dialysis access device is a permanent tunneled dialysis graft connected to a central venous catheter and is used in patients with end-stage dialysis access (ESDA) issues secondary to central venous stenosis. The safety and effectiveness of the HeRO device has previously been proven, but no study thus far has compared the cost of its use with tunneled dialysis catheters (TDCs) and thigh grafts in patients with ESDA. A decision analytic model was developed to simulate outcomes for patients with ESDA undergoing placement of a HeRO dialysis access device, TDC, or thigh graft. Outcomes of interest were infection, thrombosis, and ischemic events. Baseline values, ranges, and costs were determined from a systematic review of the literature. Total costs were based on 1 year of post-procedure outcomes. Sensitivity analyses were conducted to test model strength. The HeRO dialysis access device is the least costly dialysis access with an average 1-year cost of $6521. The 1-year cost for a TDC was $8477. A thigh graft accounted for $9567 in a 1-year time period. The HeRO dialysis access device is the least costly method of ESDA. The primary determinants of cost in this model are infection in TDCs and leg ischemia necessitating amputation in thigh grafts. Further study is necessary to incorporate patient preference and quality of life into the model. Copyright © 2012 Elsevier Inc. All rights reserved.

  16. Foulant Analysis of Three RO Membranes Used in Treating Simulated Brackish Water of the Iraqi Marshes

    PubMed Central

    Sachit, Dawood Eisa; Veenstra, John N.

    2017-01-01

    In this work, three different types of Reverse Osmosis (RO) (Thin-Film Composite (SE), Cellulose Acetate (CE), and Polyamide (AD)) were used to perform foulant analysis (autopsy) study on the deposited materials from three different simulated brackish surface feed waters. The brackish surface water qualities represented the water quality in Iraqi marshes. The main foulants from the simulated feed waters were characterized by using Scanning Electron Microscope (SEM) images and Energy-Dispersive X-ray Spectroscopy (EDXS) spectra. The effect of feed water temperatures (37 °C and 11 °C) on the formation of the fouled material deposited on the membrane surface was examined in this study. Also, pretreatment by a 0.1 micron microfiltration (MF) membrane of the simulated feed water in advance of the RO membrane on the precipitated material on the membrane surface was investigated. Finally, Fourier Transform Infrared Spectroscopy (FTIR) analysis was used to identify the functional groups of the organic matter deposited on the RO membrane surfaces. The SEM images and EDSX spectra suggested that the fouled material was mainly organic matter, and the major crystal deposited on the RO membrane was calcium carbonate (CaCO3). The FTIR spectra of the fouled RO membranes suggested that the constituents of the fouled material included aliphatic and aromatic compounds. PMID:28406468

  17. Modeling Techniques for Shipboard Manning: A Review and Plan for Development

    DTIC Science & Technology

    1993-02-01

    manning levels. Once manning models have been created, experiments can be conducted to show how changes in the manning structure might affect ship safety...these predictions, users of the manning models can evaluate how changes in crew configurations, manning levels, and voyage profiles affect ship safety...mitigate emergency situations would provide crucial information on how changes in manning structure would affect overall ship safety. Like emergency

  18. The Roles of Tidal Evolution and Evaporative Mass Loss in the Origin of CoRoT-7 b

    NASA Technical Reports Server (NTRS)

    Jackson, Brian; Miller, Neil; Barnes, Rory; Raymond, Sean N.; Fortney, Jonathan J.; Greenberg, Richard

    2010-01-01

    CoRoT-7 b is the first confirmed rocky exoplanet, but, with an orbital semimajor axis of 0.0172 au, its origins may be unlike any rocky planet in our Solar System. In this study, we consider the roles of tidal evolution and evaporative mass loss in CoRoT-7 b's history, which together have modified the planet's mass and orbit. If CoRoT-7 b has always been a rocky body, evaporation may have driven off almost half its original mass, but the mass loss may depend sensitively on the extent of tidal decay of its orbit. As tides caused CoRoT-7 b's orbit to decay, they brought the planet closer to its host star, thereby enhancing the mass loss rate. Such a large mass loss also suggests the possibility that CoRoT-7 b began as a gas giant planet and had its original atmosphere completely evaporated. In this case, we find that CoRoT-7 b's original mass probably did not exceed 200 Earth masses (about two-third of a Jupiter mass). Tides raised on the host star by the planet may have significantly reduced the orbital semimajor axis, perhaps causing the planet to migrate through mean-motion resonances with the other planet in the system, CoRoT-7 c. The coupling between tidal evolution and mass loss may be important not only for CoRoT-7 b but also for other close-in exoplanets, and future studies of mass loss and orbital evolution may provide insight into the origin and fate of close-in planets, both rocky and gaseous.

  19. Immune response against the coiled coil domain of Sjögren's syndrome associated autoantigen Ro52 induces salivary gland dysfunction.

    PubMed

    Sroka, Magdalena; Bagavant, Harini; Biswas, Indranil; Ballard, Abigail; Deshmukh, Umesh S

    2018-01-31

    The structural domains of Ro52, termed the RING, B-box, coiled coil (CC) and B30.2/SPRY are targets of anti-Ro52 in multiple autoimmune disorders. In Sjögren's syndrome patients, the presence of anti-Ro52 is associated with higher disease severity, and in mice, they induce salivary gland hypofunction. This study was undertaken to investigate whether immune responses against different domains of Ro52, influences salivary gland disease in mice. Female NZM2758 mice were immunised with Ro52 domains expressed as recombinant fusion proteins with maltose binding protein (MBP) [MBP-RING-B-box, MBP-CC, MBP-CC(ΔC19), MBP-B30.2/SPRY]. Sera from immunised mice were studied for IgG antibodies to Ro52 by immunoprecipitation, and to salivary gland cells by immunofluorescence. Pilocarpine-induced saliva production was measured to evaluate salivary gland function. Submandibular glands were investigated by histopathology for inflammation and by immune-histochemistry for IgG deposition. Mice immunised with different Ro52-domains had comparable reactivity to Ro52 and to salivary gland cells. However, only mice immunised with the CC domain and its C-terminal truncated version CC(ΔC19) showed a significant drop in saliva production. None of the mice developed severe salivary gland inflammation. The salivary gland hypofunction significantly correlated with increased intra-lobar IgG deposits in the submandibular salivary glands. Our data demonstrate that epitope specificity of anti-Ro52 antibodies plays a critical role in the induction of glandular dysfunction. Clearly, screening Sjögren's syndrome patients for relative levels of Ro52 domain specific antibodies will be more informative for associating anti-Ro52 with clinical measures of the disorder.

  20. Liver of the "visible man".

    PubMed

    Fasel, J H; Gingins, P; Kalra, P; Magnenat-Thalmann, N; Baur, C; Cuttat, J F; Muster, M; Gailloud, P

    1997-01-01

    Endoscopic surgery, also called minimally invasive surgery, is presumed drastically to reduce postoperative morbidity and thus to offer both human and economic benefits. For the surgeon, however, this approach leads to a number of gestural challenges that require extensive training to be mastered. In order to replace experimentation on animals and patients, we developed a simulator for endoscopic surgery. To achieve this goal, a first step was to develop a working prototype, a "standard patient," on which the informatic and microengineering tools could be validated. We used the visible man dataset for this purpose. The external shape of the visible man's liver, his biliary passages, and his extrahepatic portal system turned out to be fully within the standard pattern of normal anatomy. Anatomic variations were observed in the intrahepatic right portal vein, the hepatic veins, and the arterial blood supply to the liver. Thus, the visible man dataset reveals itself to be well suited for the simulation of minimally invasive surgical operation such as endoscopic cholecystectomy.

  1. Ecology is a white man's problem

    Treesearch

    Francisco P. Valenzuela

    1995-01-01

    A synthesis of statements and research is presented on different minority communities, and a response to the statement that "ecology is a white man’s problem" is examined. These characterizations provide insight into why ecology may be perceived as a "white man’s problem." The common themes are then used to develop several suggested agency responses...

  2. The Computerized Anatomical Man (CAM) model

    NASA Technical Reports Server (NTRS)

    Billings, M. P.; Yucker, W. R.

    1973-01-01

    A computerized anatomical man (CAM) model, representing the most detailed and anatomically correct geometrical model of the human body yet prepared, has been developed for use in analyzing radiation dose distribution in man. This model of a 50-percentile standing USAF man comprises some 1100 unique geometric surfaces and some 2450 solid regions. Internal body geometry such as organs, voids, bones, and bone marrow are explicitly modeled. A computer program called CAMERA has also been developed for performing analyses with the model. Such analyses include tracing rays through the CAM geometry, placing results on magnetic tape in various forms, collapsing areal density data from ray tracing information to areal density distributions, preparing cross section views, etc. Numerous computer drawn cross sections through the CAM model are presented.

  3. AmeriFlux US-Ro6 Rosemount I18_North

    DOE Data Explorer

    Baker, John [USDA-ARS; Griffis, Tim [University of Minnesota

    2018-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-Ro6 Rosemount I18_North. Site Description - This tower is located in a farm field farmed in accordance with a conservation type agricultural practice in the region: a corn/soybean/clover (living mulch/cover crop) rotation with chisel plow tillage in the fall following corn harvest and in the spring following soybeans.

  4. Korean Affairs Report

    DTIC Science & Technology

    1985-04-22

    DPRK-Romanian Relations (KCNA, various dates) 147 Kang Song-san Greets Romanian Counterpart 147 Kim Yong -nam Greets Romanian Counterpart 147...Independence Marked (KCNA, 3, 4 Apr 85) . 152 Papers Observe Anniversary 152 Greetings Sent 152 Independence Day Rally 153 Kim Yong -nam Message 153...them. In their speeches at the meeting Kim Chang- yong , vice-chairman of the Central Committee of the League of Socialist Working Youth, students of

  5. Report on the Hemodialysis Reliable Outflow (HeRO) experience in dialysis patients with central venous occlusions.

    PubMed

    Wallace, Justin R; Chaer, Rabih A; Dillavou, Ellen D

    2013-09-01

    The Hemodialysis Reliable Outflow (HeRO) graft (Hemosphere/CryoLife Inc, Eden Prairie, Minn) has provided an innovative means to obtain hemodialysis access for patients with severe central venous occlusive disease. The outcomes of this novel treatment modality in a difficult population have yet to be clearly established. A retrospective review of HeRO graft placement from June 2010 to January 2012 was performed. Patient hemodialysis access history, clinical complexity, complications, and outcomes were analyzed. Categoric data were described with counts and proportions, and continuous data with means, ranges and, when appropriate, standard deviations. Patency rates were analyzed using life-table analysis, and patency rate comparisons were made with a two-group proportion comparison calculator. HeRO graft placement was attempted 21 times in 19 patients (52% women), with 18 of 21 (86%) placed successfully. All but one was placed in the upper extremity. Mean follow-up after successful placement has been 7 months (range, 0-23 months). The primary indication for all HeRO graft placements except one was central vein occlusion(s) and need for arteriovenous access. Patients averaged 2.0 previous (failed) accesses and multiple catheters. Four HeRO grafts (24%), all in women, required ligation and removal for severe steal symptoms in the immediate postoperative period (P < .01 vs men). Three HeROs were placed above fistulas for rescue. All thrombosed <4 months, although the fistulas remained open. An infection rate of 0.5 bacteremic events per 1000 HeRO-days was observed. At a mean follow-up of 7 months, primary patency was 28% and secondary patency was 44%. The observed 12-month primary and secondary patency rates were 11% and 32%, respectively. Secondary patency was maintained in four patients for a mean duration of 10 months (range, 6-18 months), with an average of 4.0 ± 2.2 thrombectomies per catheter. HeRO graft placement, when used as a last-resort measure, has been

  6. Why Man Explores

    NASA Technical Reports Server (NTRS)

    1976-01-01

    This NASA Educational Publication was prepared from a transcript of a panel discussion held on July 2, 1976, in conjunction with the Viking Missions to Mars. The members of the Why Man Explores panel were selected as authorities in classical disciplines relating to exploration.

  7. Manned geosynchronous mission requirements and system analysis study extension. Manned Orbital Transfer Vehicle (MOTV) capabilities handbook and user guide

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The primary change in crew capsule definition is a smaller MOTV crew capsule, switching from a 3-man capsule to a 2-man capsule. A second change permitted crew accommodations for sleeping and privacy to be combined with the flight station. The current baseline DRM, ER1, requires 2 men for 3 to 4 days to repair a multi-disciplined GOE Platform and a modest amount of mission dedicated hardware. A 2-man MOTV crew capsule to be used as a design reference point for the OTV, and its interfaces between the STS and other associated equipment or facilities are described in detail. The functional capabilities of the 2-man capsule, as well as its application to a wide range of generic missions, is also presented. The MOTV turnaround is addressed and significant requirements for both space based and ground based scenarios are summarized.

  8. Differential cross-reactivity of monoclonal antibody OPD4 (anti-CD45RO) in macaques.

    PubMed

    Wang, Xiaolei; Pahar, Bapi; Rasmussen, Terri; Alvarez, Xavier; Dufour, Jason; Rasmussen, Kelsi; Lackner, Andrew A; Veazey, Ronald S

    2008-01-01

    Immunologic research in nonhuman primates is occasionally limited by the availability of reagents that cross-react in nonhuman primates. One major limitation has been the lack of a monoclonal antibody to CD45RO. Although the monoclonal antibody UCHL-1 is used to detect CD45RO isoforms in humans, it does not react with nonhuman primates, mandating the use of alternative strategies to define "memory" T cell responses in nonhuman primates. The current study examined the reactivity and specificity of another antibody against CD45RO, clone OPD4, in macaques. Here we demonstrate that OPD4 specifically labels memory CD4+ T cells in approximately 44% of rhesus macaques (Macaca mulatta) of Indian but not Chinese origin. In contrast, tissues from pigtail macaques (Macaca nemestrina) react with this clone, indicating that OPD4 may be useful for examining memory CD4+ T cells in certain macaques, but its utility may be limited in other species or even among individual macaques.

  9. Differential cross-reactivity of monoclonal antibody OPD4 (anti-CD45RO) in macaques

    PubMed Central

    Wang, Xiaolei; Pahar, Bapi; Rasmussen, Terri; Alvarez, Xavier; Dufour, Jason; Rasmussen, Kelsi; Lackner, Andrew A.; Veazey, Ronald S.

    2008-01-01

    Immunologic research in nonhuman primates is occasionally limited by the availability of reagents that cross react in nonhuman primates. One major limitation has been the lack of a monoclonal antibody to CD45RO. Although the monoclonal antibody UCHL-1 is used to detect CD45RO isoforms in humans, it does not react with nonhuman primates, mandating the use of alternative strategies to define “memory” T cell responses in nonhuman primates. The current study examined the reactivity and specificity of another antibody against CD45RO, clone OPD4, in macaques. Here we demonstrate that OPD4 specifically labels memory CD4+ T cells in ~44% of rhesus macaques (Macaca mulatta) of Indian, but not Chinese origin. In contrast, tissues from pigtail macaques (Macaca nemestrina) react with this clone, indicating that OPD4 may be useful for examining memory CD4+ T cells in certain macaques, but its utility may be limited in other species or even among individual macaques. PMID:18304631

  10. High tumor levels of IL6 and IL8 abrogate preclinical efficacy of the γ-secretase inhibitor, RO4929097.

    PubMed

    He, Wei; Luistro, Leopoldo; Carvajal, Daisy; Smith, Melissa; Nevins, Tom; Yin, Xuefeng; Cai, James; Higgins, Brian; Kolinsky, Kenneth; Rizzo, Christine; Packman, Kathryn; Heimbrook, David; Boylan, John F

    2011-06-01

    Interest continues to build around the early application of patient selection markers to prospectively identify patients likely to show clinical benefit from cancer therapies. Hypothesis generation and clinical strategies often begin at the preclinical stage where responder and nonresponder tumor cell lines are first identified and characterized. In the present study, we investigate the drivers of in vivo resistance to the γ-secretase inhibitor RO4929097. Beginning at the tissue culture level, we identified apparent IL6 and IL8 expression differences that characterized tumor cell line response to RO4929097. We validated this molecular signature at the preclinical efficacy level identifying additional xenograft models resistant to the in vivo effects of RO4929097. Our data suggest that for IL6 and IL8 overexpressing tumors, RO4929097 no longer impacts angiogenesis or the infiltration of tumor associated fibroblasts. These preclinical data provide a rationale for preselecting patients possessing low levels of IL6 and IL8 prior to RO4929097 dosing. Extending this hypothesis into the clinic, we monitored patient IL6 and IL8 serum levels prior to dosing with RO4929097 during Phase I. Interestingly, the small group of patients deriving some type of clinical benefit from RO4929097 presented with low baseline levels of IL6 and IL8. Our data support the continued investigation of this patient selection marker for RO4929097 and other types of Notch inhibitors undergoing early clinical evaluation. Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

  11. Manned Venus Flyby

    NASA Technical Reports Server (NTRS)

    Feldman, M. S.; Ferrara, L. A.; Havenstein, P. L.; Volonte, J. E.; Whipple, P. H.

    1967-01-01

    This study is one of several being conducted at Bellcomm and in Manned Space Flight whose purpose is to give guidance to the Apollo Applications Program's technical objectives by focusing on a longer range goal. The assumed mission in this case is a three-man flyby of Venus launched in November, 1973 on a single standard Saturn V. The selected flight configuration includes a Command and Service Module similar in some respects to Apollo, an Environmental Support Module which occupies the adapter area and a spent S-IVB stage which is utilized for habitable volume and structural support of a solar cell electrical power system. The total injected weight, 106,775 lbs., is within the capability of a single Saturn V of the early 1970's. The study is focused on the selection of subsystem technologies appropriate to long duration flight. The conclusions are reported in terms of the technical characteristics to be achieved as part of the Apollo Applications Program's long duration objectives.

  12. Measurements of Man-Made Spectrum Noise Floor

    NASA Technical Reports Server (NTRS)

    Enge, Per; Akos, Dennis; Do, Juyong; Simoneau, Joel B.; Pearson, L. Wilson; Seetharam, Venkatesh; Oria, A. J. (Editor)

    2004-01-01

    This report consolidates research carried out at Clemson University and Stanford University where a series of measurements were undertaken to identify the man-made radiation present in four bands used by rather different services, namely, L1 Band (1563.42 1587.42 MHz), the Unified S-Band (2025 2110 MHz), the 2.4 GHz Industrial, Scientific and Medical (ISM) Band (2400 2482.50 MHz), and the 23.6-24.0 GHz Passive Sensing Band. Results show that there were distinctive differences in the measurement data in the frequency bands, which should be expected based on the function/regulation associated with each. The GPS L1 Band had little to none terrestrial man-made sources, but the ISM 2.4 GHz Band had a large number of man-made sources regardless of the site and the time. The Unified S Band showed mixed results depending on the sites. The Passive Sensing Band does not contain appreciable man-made radiation.

  13. Novel antidepressant candidate RO-05 modulated glucocorticoid receptors activation and FKBP5 expression in chronic mild stress model in rats.

    PubMed

    Xing, Y; Hou, J; Meng, Q; Yang, M; Kurihara, H; Tian, J

    2015-04-02

    In this study, a novel TRI (triple reuptake inhibitors) antidepressant candidate RO-05 (4-[1-[1-(benzoyloxy)cyclohexyl]-2-(dimethylamino)ethyl]-phenyl benzoate) was investigated in TST (tail suspension test), FST (forced swimming test) and CMS (chronic mild stress) model. Results showed RO-05 significantly decreased the immobility time in FST and TST at 4.5-, 9-, 18-mg/kg in rats and 9-, 18-, 36-mg/kg in mice. Chronic administration of 18-mg/kg RO-05 improved the behavioral index, anhedonia and normalized the hyperactivity of HPA (hypothalamic-pituitary-adrenal axis) of CMS rats. We further investigated the possible mechanisms of RO-05 in the CMS model. Eighteen milligrams per kilogram of RO-05 chronic administration significantly reversed the increase of mRNA and protein expression of FKBP5 in the CMS rat hippocampus, which facilitated the activation of GR- (glucocorticoid receptor) and GR-responsive gene Foxo1 expression. RO-05 also elevated the expression of BDNF (brain-derived neurotrophic factor) in CMS rat hippocampus. In summary, our results indicated that RO-05 is a promising antidepressant candidate. The possible antidepressant mechanisms of RO-05 were the modulation of FKBP5 expression, GR activation, corresponding inhibition of HPA axis hyperactivity, and the increase of BDNF expression. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

  14. How was the Turin Shroud Man crucified?

    PubMed

    Bevilacqua, M; Fanti, G; D'Arienzo, M; Porzionato, A; Macchi, V; De Caro, R

    2014-12-01

    As the literature is not exhaustive with reference to the way the Turin Shroud (TS) Man was crucified, and it is not easy to draw significant information from only a "photograph" of a man on a linen sheet, this study tries to add some detail on this issue based on both image processing of high resolution photos of the TS and on experimental tests on arms and legs of human cadavers. With regard to the TS Man hands, a first hypothesis states that the left hand of the TS Man was nailed twice at two different anatomical sites: the midcarpal joint medially to the pisiform between the lunate/pyramidal and capitate/uncinate bones (Destot's space) and the radiocarpal joint between the radio, lunate and scaphoid; also the right hand would have been nailed twice. A second hypothesis, preferred by the authors, states that the hands were nailed only once in the Destot's space with partial lesion of the ulnar nerve and flexion of the metacarpophalangeal joint of the thumbs. With regard to the TS Man feet, the imprint of the sole of the right foot leads to the conclusion that TS Man suffered a dislocation at the ankle just before the nailing. The entrance hole of the nail on the right foot is a few inches from the ankle, and excludes a double nailing. The nail has been driven between the tarsal bones. The TS Man suffered the following tortures during crucifixion: a very serious and widespread causalgia due to total paralysis of the upper right limb (paradoxical causalgia); a nailing of the left wrist with damage to the ulnar nerve; a similar nailing of the right wrist; and a nailing to both feet using one only nail that injured the plantaris medialis nerves. The respiratory limitation was probably not sufficient to cause death by asphyxiation. Also considering the hypovolemia produced by scourging and the many other tortures detectable on the TS, the principal cause of death can be attributed to a myocardial infarction. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. Quantum scattering calculations for ro-vibrational de-excitation of CO by hydrogen atoms

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Song, Lei; Avoird, Ad van der; Karman, Tijs

    2015-05-28

    We present quantum-mechanical scattering calculations for ro-vibrational relaxation of carbon monoxide (CO) in collision with hydrogen atoms. Collisional cross sections of CO ro-vibrational transitions from v = 1, j = 0 − 30 to v′ = 0, j′ are calculated using the close coupling method for collision energies between 0.1 and 15 000 cm{sup −1} based on the three-dimensional potential energy surface of Song et al. [J. Phys. Chem. A 117, 7571 (2013)]. Cross sections of transitions from v = 1, j ≥ 3 to v′ = 0, j′ are reported for the first time at this level of theory. Alsomore » calculations by the more approximate coupled states and infinite order sudden (IOS) methods are performed in order to test the applicability of these methods to H–CO ro-vibrational inelastic scattering. Vibrational de-excitation rate coefficients of CO (v = 1) are presented for the temperature range from 100 K to 3000 K and are compared with the available experimental and theoretical data. All of these results and additional rate coefficients reported in a forthcoming paper are important for including the effects of H–CO collisions in astrophysical models.« less

  16. 46 CFR 131.920 - Level of manning.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Level of manning. 131.920 Section 131.920 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS OPERATIONS Miscellaneous § 131.920 Level of manning. Each vessel must carry the personnel required by the Certificate of...

  17. 46 CFR 131.420 - Manning and supervision.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Manning and supervision. 131.420 Section 131.420 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS OPERATIONS Sufficiency and Supervision of Crew of Survival Craft § 131.420 Manning and supervision. (a) There must be...

  18. 46 CFR 131.420 - Manning and supervision.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Manning and supervision. 131.420 Section 131.420 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS OPERATIONS Sufficiency and Supervision of Crew of Survival Craft § 131.420 Manning and supervision. (a) There must be...

  19. 46 CFR 131.920 - Level of manning.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Level of manning. 131.920 Section 131.920 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS OPERATIONS Miscellaneous § 131.920 Level of manning. Each vessel must carry the personnel required by the Certificate of...

  20. 46 CFR 131.920 - Level of manning.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Level of manning. 131.920 Section 131.920 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS OPERATIONS Miscellaneous § 131.920 Level of manning. Each vessel must carry the personnel required by the Certificate of...

  1. 46 CFR 131.420 - Manning and supervision.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Manning and supervision. 131.420 Section 131.420 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS OPERATIONS Sufficiency and Supervision of Crew of Survival Craft § 131.420 Manning and supervision. (a) There must be...

  2. 46 CFR 131.920 - Level of manning.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Level of manning. 131.920 Section 131.920 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS OPERATIONS Miscellaneous § 131.920 Level of manning. Each vessel must carry the personnel required by the Certificate of...

  3. 46 CFR 131.420 - Manning and supervision.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Manning and supervision. 131.420 Section 131.420 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS OPERATIONS Sufficiency and Supervision of Crew of Survival Craft § 131.420 Manning and supervision. (a) There must be...

  4. Korean Affairs Report.

    DTIC Science & Technology

    1987-02-12

    TRADE Government Revises Foreign Capital Investment Policy ( Kim Yong -hun; PUSAN SANGGONG, Nov 86) 32 NORTH KOREA POLITICS AND GOVERNMENT NODONG...PUSAN SANGGONG in Korean Nov 86 pp 64-65 [Article by Kim Yong -hun, director of the International Technology Transfer Research Center of Korea...leader in his historic policy speech. At the soldiers’ rally in the unit to which Comrade Cha Myong-pok belongs, Kim Chang- yong , a KPA general

  5. Man and Society

    ERIC Educational Resources Information Center

    Lyons, Thomas T.

    1972-01-01

    Description of three years' experience with an interdisciplinary, field experience course, Man & Society," instituted at the Phillips Academy in 1970. It involved comparative societal study with a nine-week working and living experience in Boston and Mexico, a combination of student, teacher, and joint leadership, group discussion, and joint…

  6. Pregnancy Outcomes in Patients with Autoimmune Diseases and Anti-Ro/SSA Antibodies

    PubMed Central

    Cimaz, Rolando; Caporali, Roberto; Ramoni, Véronique; Buyon, Jill

    2013-01-01

    Anti-Ro/SSA antibodies are associated with neonatal lupus (congenital heart block (CHB), neonatal transient skin rash, hematological and hepatic abnormalities), but do not negatively affects other gestational outcomes, and the general outcome of these pregnancies is now good, when followed by experienced multidisciplinary teams. The prevalence of CHB, defined as an atrioventricular block diagnosed in utero, at birth, or within the neonatal period (0–27 days after birth), in the offspring of an anti-Ro/SSA-positive women is 1–2%, of neonatal lupus rash around 10–20%, while laboratory abnormalities in asymptomatic babies can be detected in up to 27% of cases. The risk of recurrence of CHB is ten times higher. Most of the mothers are asymptomatic at delivery and are identified only by the birth of an affected child. Half of these asymptomatic women develop symptoms of a rheumatic disease, most commonly arthralgias and xerophtalmia, but few develop lupus nephritis. A standard therapy for CHB is still matter of investigation, although fluorinated corticosteroids have been reported to be effective for associated cardiomyopathy. Serial echocardiograms and obstetric sonograms, performed at least every 1–2 weeks starting from the 16th week of gestational age, are recommended in anti-Ro/SSA-positive pregnant women to detect early fetal abnormalities that might be a target of preventive therapy. PMID:20012231

  7. Efficiently Combining Water Reuse and Desalination through Forward Osmosis-Reverse Osmosis (FO-RO) Hybrids: A Critical Review.

    PubMed

    Blandin, Gaetan; Verliefde, Arne R D; Comas, Joaquim; Rodriguez-Roda, Ignasi; Le-Clech, Pierre

    2016-07-01

    Forward osmosis (FO) is a promising membrane technology to combine seawater desalination and water reuse. More specifically, in a FO-reverse osmosis (RO) hybrid process, high quality water recovered from the wastewater stream is used to dilute seawater before RO treatment. As such, lower desalination energy needs and/or water augmentation can be obtained while delivering safe water for direct potable reuse thanks to the double dense membrane barrier protection. Typically, FO-RO hybrid can be a credible alternative to new desalination facilities or to implementation of stand-alone water reuse schemes. However, apart from the societal (public perception of water reuse for potable application) and water management challenges (proximity of wastewater and desalination plants), FO-RO hybrid has to overcome technical limitation such as low FO permeation flux to become economically attractive. Recent developments (i.e., improved FO membranes, use of pressure assisted osmosis, PAO) demonstrated significant improvement in water flux. However, flux improvement is associated with drawbacks, such as increased fouling behaviour, lower rejection of trace organic compounds (TrOCs) in PAO operation, and limitation in FO membrane mechanical resistance, which need to be better considered. To support successful implementation of FO-RO hybrid in the industry, further work is required regarding up-scaling to apprehend full-scale challenges in term of mass transfer limitation, pressure drop, fouling and cleaning strategies on a module scale. In addition, refined economics assessment is expected to integrate fouling and other maintenance costs/savings of the FO/PAO-RO hybrid systems, as well as cost savings from any treatment step avoided in the water recycling.

  8. Learning Processes in Man, Machine and Society

    ERIC Educational Resources Information Center

    Malita, Mircea

    1977-01-01

    Deciphering the learning mechanism which exists in man remains to be solved. This article examines the learning process with respect to association and cybernetics. It is recommended that research should focus on the transdisciplinary processes of learning which could become the next key concept in the science of man. (Author/MA)

  9. Southern Appalachian Man and the Biosphere - SAMAB.ORG

    Science.gov Websites

    Southern Appalachian Man and the Biosphere Home Who We Are SAMAB Initiatives Archives Welcome to SAMAB This slideshow requires JavaScript. The Southern Appalachian Man and the Biosphere (SAMAB

  10. The Ideal Man and Woman According to University Students

    ERIC Educational Resources Information Center

    Weinstein, Lawrence; Laverghetta, Antonio V.; Peterson, Scott A.

    2009-01-01

    The present study determined if the ideal man has changed over the years and who and what the ideal woman is. We asked students at Cameron University to rate the importance of character traits that define the ideal man and woman. Subjects also provided examples of famous people exemplifying the ideal, good, average, and inferior man and woman. We…

  11. Man-in-the-control-loop simulation of manipulators

    NASA Technical Reports Server (NTRS)

    Chang, J. L.; Lin, Tsung-Chieh; Yae, K. Harold

    1989-01-01

    A method to achieve man-in-the-control-loop simulation is presented. Emerging real-time dynamics simulation suggests a potential for creating an interactive design workstation with a human operator in the control loop. The recursive formulation for multibody dynamics simulation is studied to determine requirements for man-in-the-control-loop simulation. High speed computer graphics techniques provides realistic visual cues for the simulator. Backhoe and robot arm simulations are implemented to demonstrate the capability of man-in-the-control-loop simulation.

  12. The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Espinosa, Alexander; Oke, Vilija; Elfving, Ase

    2008-12-10

    Patients with the systemic autoimmune diseases Sjoegrens's syndrome and systemic lupus erythematosus often have autoantibodies against the intracellular protein Ro52. Ro52 is an E3 ligase dependent on the ubiquitin conjugation enzymes UBE2D1 and UBE2E1. While Ro52 and UBE2D1 are cytoplasmic proteins, UBE2E1 is localized to the nucleus. Here, we investigate how domains of human Ro52 regulate its intracellular localization. By expressing fluorescently labeled Ro52 and Ro52 mutants in HeLa cells, an intact coiled-coil domain was found to be necessary for the cytoplasmic localization of Ro52. The amino acids 381-470 of the B30.2 region were essential for translocation into the nucleus.more » Furthermore, after exposure of HeLa cells to the inflammatory mediator nitric oxide (NO), Ro52 translocated to the nucleus. A nuclear localization of Ro52 in inflamed tissue expressing inducible NO synthetase (iNOS) from cutaneous lupus patients was observed by immunohistochemistry and verified in NO-treated cultures of patient-derived primary keratinocytes. Our results show that the localization of Ro52 is regulated by endogenous sequences, and that nuclear translocation is induced by an inflammatory mediator. This suggests that Ro52 has both cytoplasmic and nuclear substrates, and that Ro52 mediates ubiquitination through UBE2D1 in the cytoplasm and through UBE2E1 in the nucleus.« less

  13. Comparison of COSMIC RO Data with European Digisondes and GPS TEC measurements

    NASA Astrophysics Data System (ADS)

    Zakharenkova, Irina; Krypiak-Gregorczyk, Anna; Shagimuratov, Irk; Krankowski, Andrzej; Lagovsky, Anatoly

    FormoSat-3/COSMIC now provides unprecedented global coverage of GPS occultations mea-surements, each of which yields the ionosphere electron density information with high vertical resolution. However systematic validation work is still needed before using the powerful RO technique for sounding the ionosphere on a routine basis. In the given study electron density profiles retrieved from the Formosat-3/COSMIC RO measurements were compared with differ-ent kinds of ground-based observations. We used the ionospheric data recorded by European digisondes of DIAS network (Rome, Ebro, Arenosillo, Athens, Chilton, Pruhonice and Julius-ruh) for temporal interval of 2007-2009 and compare these ground measured data with the GPS COSMIC RO ionospheric profiles. It was revealed that in general the form of COSMIC profile in the bottom side is in a good agreement with ionosonde profiles, the heights of the peak density value are also good comparable. Special attention was focused to the question of the topside part of electron density profile. Practically for all analyzed cases there are observed the understated values of electron density in the topside part of the ionosonde profiles in compare with RO profiles. As the topside ionosonde profile is obtained by fitting a model to the peak electron density value, the COSMIC radio occultation measurements can make an important contribution to the investigation of the topside part of the ionosphere. In order to assess the ac-curacy of the COSMIC ionospheric electron density retrievals, coincidences of ionosonde data with COSMIC NmF2 values have been examined. NmF2 was calculated from the observed critical plasma frequency foF2 of the F2 layer. Values of foF2 have been scaled manually from ionograms for all considered time-location cases to avoid the evident risks related with using of the autoscaled data. The created scatter plots show a high degree of correlation between two independent estimates of NmF2. Also it was analyzed the

  14. Asteroseismology and mass loss in Be stars. Study with CoRoT

    NASA Astrophysics Data System (ADS)

    Diago, P. D.

    The general aim of this work is the study of Be stars with the CoRoT space mission. The mechanisms responsible of the production and dynamics of the circumstellar gas in Be stars are still not constrained. Observations of non-radial pulsation beating phenomena connected to outbursts point toward a relevance of pulsation, but this mechanism cannot be generalized. In this regard, the observation of classical Be stars with the high-precision CoRoT satellite is providing important keys to understand the physics of these objects and the nature of the Be phenomenon. In order to study the light variations of the selected stars we use photometric and spectroscopic observations. These observations allow us to extract frequencies, amplitudes and phases of these variations. As we will show, these light variations can be connected with pulsations on the stellar surface. For carrying out the frequency analysis we have developed a new code based on standard Fourier analysis. The point is that this code, called PASPER, allows the frequency analysis of large sets of light curves in an automatic mode. This Ph.D. thesis is arranged as follows: In the first three Chapters we describe the scientific framework of this project, giving a brief description on Asteroseismology, presenting the current status of Be stars, and describing the basics of the Fourier analysis and the rudiments of the time series analysis. At the early begin of this Ph.D. thesis, the CoRoT satellite was still on ground getting ready for the launch. In this context, we perform a search for short-period B and Be star variables in the low metallicity environment of the Magellanic Clouds. This study constitutes the Part I of this Ph.D. thesis. This Part has a double goal: i) to test the frequency analysis codes; and ii) to detect observationally beta Cephei and SPB-like B-type pulsators in low metallicity environments, actually not predicted by the pulsational theory and models. This constitutes the PartI. Part II is

  15. RevManHAL: towards automatic text generation in systematic reviews.

    PubMed

    Torres Torres, Mercedes; Adams, Clive E

    2017-02-09

    Systematic reviews are a key part of healthcare evaluation. They involve important painstaking but repetitive work. A major producer of systematic reviews, the Cochrane Collaboration, employs Review Manager (RevMan) programme-a software which assists reviewers and produces XML-structured files. This paper describes an add-on programme (RevManHAL) which helps auto-generate the abstract, results and discussion sections of RevMan-generated reviews in multiple languages. The paper also describes future developments for RevManHAL. RevManHAL was created in Java using NetBeans by a programmer working full time for 2 months. The resulting open-source programme uses editable phrase banks to envelop text/numbers from within the prepared RevMan file in formatted readable text of a chosen language. In this way, considerable parts of the review's 'abstract', 'results' and 'discussion' sections are created and a phrase added to 'acknowledgements'. RevManHAL's output needs to be checked by reviewers, but already, from our experience within the Cochrane Schizophrenia Group (200 maintained reviews, 900 reviewers), RevManHAL has saved much time which is better employed thinking about the meaning of the data rather than restating them. Many more functions will become possible as review writing becomes increasingly automated.

  16. CaveMan Enterprise version 1.0 Software Validation and Verification.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hart, David

    The U.S. Department of Energy Strategic Petroleum Reserve stores crude oil in caverns solution-mined in salt domes along the Gulf Coast of Louisiana and Texas. The CaveMan software program has been used since the late 1990s as one tool to analyze pressure mea- surements monitored at each cavern. The purpose of this monitoring is to catch potential cavern integrity issues as soon as possible. The CaveMan software was written in Microsoft Visual Basic, and embedded in a Microsoft Excel workbook; this method of running the CaveMan software is no longer sustainable. As such, a new version called CaveMan Enter- prisemore » has been developed. CaveMan Enterprise version 1.0 does not have any changes to the CaveMan numerical models. CaveMan Enterprise represents, instead, a change from desktop-managed work- books to an enterprise framework, moving data management into coordinated databases and porting the numerical modeling codes into the Python programming language. This document provides a report of the code validation and verification testing.« less

  17. Korean Affairs Report

    DTIC Science & Technology

    1986-03-31

    Weinberger to open negotiations over the issue. North Korean Foreign Minister Kim Yong -nam expressed his willingness to comply with the U.S...dummy? The ruling party’s proposal in itself certainly is a change, but it is not reasonable. After a few consultations with Kim Tae-chung, Kim Yong -sam...Hungsadan Hall, making a. human tide which paralyzed traffic. As the crowd was growing out of their control, Yi Min-u and Kim Yong -sam stopped to

  18. Korean Affairs Report

    DTIC Science & Technology

    1985-08-19

    SOUTH KOREA POLITICS AND GOVERNMENT NKDP Post-Election Tasks, Problems Scrutinized (HANGUK ILBO, 17 Feb 85) • 63 67 Kim Tae-chung, Kim Yong -sam...National Day 122 Kim Il-song Sends Greetings 123 Kim Yong -nam Greets Maldives Counterpart 123 Kim Il-song Greets Peru President on National Day (KCNA, 27...including Kim Tae- yong , member of the Subcommittee for the Masses of the Sammin Struggle Committee of the Seoul National University [SNU], Ha Tong

  19. 46 CFR 131.420 - Manning and supervision.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Manning and supervision. 131.420 Section 131.420 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS OPERATIONS Sufficiency and Supervision of Crew of Survival Craft § 131.420 Manning and supervision. (a) There must be enough trained persons aboard each survival craf...

  20. 46 CFR 131.920 - Level of manning.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Level of manning. 131.920 Section 131.920 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS OPERATIONS Miscellaneous § 131.920 Level of manning. Each vessel must carry the personnel required by the Certificate of Inspection, as determined by the cognizant OCMI,...

  1. Teaching Ideas About Man and the Environment.

    ERIC Educational Resources Information Center

    Phoenix Union High School District, AZ.

    This is a collection of papers which resulted from an assignment given in a seminar dealing with the topic Man and His Environment at Phoenix Union High School, Arizona. The interdisciplinary seminar focused on the relationships between man and his physical environment. Its purpose was to introduce the participants to the spectrum of environmental…

  2. The War in Man; Media and Machines.

    ERIC Educational Resources Information Center

    Wilhelmsen, Frederick D.; Bret, Jane

    The authors present a picture of contemporary man torn by conflicting forces, caught in a psychic house divided against itself, a victim of war between media and machines. Machines, they state, represent the rationalistic tradition which has brought man to the brink of psychic and social disaster. The media they see as offering hope--true…

  3. Alternative Frameworks for the Study of Man.

    ERIC Educational Resources Information Center

    Markova, Ivana

    1979-01-01

    Two frameworks for the study of man are discussed. The Cartesian model views man as a physical object. A dialectic framework, with the emphasis on the self, grew out of nineteenth century romanticism and reflects the theories of Hegel. Both models have had an effect on social psychology and the study of interpersonal communication. (BH)

  4. Removal of organic contaminants by RO and NF membranes

    NASA Technical Reports Server (NTRS)

    Yoon, Yeomin; Lueptow, Richard M.

    2005-01-01

    Rejection characteristics of organic and inorganic compounds were examined for six reverse osmosis (RO) membranes and two nanofiltration (NF) membranes that are commercially available. A batch stirred-cell was employed to determine the membrane flux and the solute rejection for solutions at various concentrations and different pH conditions. The results show that for ionic solutes the degree of separation is influenced mainly by electrostatic exclusion, while for organic solutes the removal depends mainly upon the solute radius and molecular structure. In order to provide a better understanding of rejection mechanisms for the RO and NF membranes, the ratio of solute radius (r(i,s)) to effective membrane pore radius (r(p)) was employed to compare rejections. An empirical relation for the dependence of the rejection of organic compounds on the ratio r(i,s)/r(p) is presented. The rejection for organic compounds is over 75% when r(i,s)/r(p) is greater than 0.8. In addition, the rejection of organic compounds is examined using the extended Nernst-Planck equation coupled with a steric hindrance model. The transport of organic solutes is controlled mainly by diffusion for the compounds that have a high r(i,s)/r(p) ratio, while convection is dominant for compounds that have a small r(i,s)/r(p) ratio. c2005 Elsevier B.V. All rights reserved.

  5. Efficiently Combining Water Reuse and Desalination through Forward Osmosis—Reverse Osmosis (FO-RO) Hybrids: A Critical Review

    PubMed Central

    Blandin, Gaetan; Verliefde, Arne R.D.; Comas, Joaquim; Rodriguez-Roda, Ignasi; Le-Clech, Pierre

    2016-01-01

    Forward osmosis (FO) is a promising membrane technology to combine seawater desalination and water reuse. More specifically, in a FO-reverse osmosis (RO) hybrid process, high quality water recovered from the wastewater stream is used to dilute seawater before RO treatment. As such, lower desalination energy needs and/or water augmentation can be obtained while delivering safe water for direct potable reuse thanks to the double dense membrane barrier protection. Typically, FO-RO hybrid can be a credible alternative to new desalination facilities or to implementation of stand-alone water reuse schemes. However, apart from the societal (public perception of water reuse for potable application) and water management challenges (proximity of wastewater and desalination plants), FO-RO hybrid has to overcome technical limitation such as low FO permeation flux to become economically attractive. Recent developments (i.e., improved FO membranes, use of pressure assisted osmosis, PAO) demonstrated significant improvement in water flux. However, flux improvement is associated with drawbacks, such as increased fouling behaviour, lower rejection of trace organic compounds (TrOCs) in PAO operation, and limitation in FO membrane mechanical resistance, which need to be better considered. To support successful implementation of FO-RO hybrid in the industry, further work is required regarding up-scaling to apprehend full-scale challenges in term of mass transfer limitation, pressure drop, fouling and cleaning strategies on a module scale. In addition, refined economics assessment is expected to integrate fouling and other maintenance costs/savings of the FO/PAO-RO hybrid systems, as well as cost savings from any treatment step avoided in the water recycling. PMID:27376337

  6. The Centauri project: Manned interstellar travel

    NASA Technical Reports Server (NTRS)

    Ciesla, Thomas M.

    1990-01-01

    The development of antimatter engines for spacecraft propulsion will allow man to expand to the nearest stellar neighbors such as the Alpha Centuri system. Compared to chemically powered rockets like the Apollo mission class which would take 50,000 years to reach the Centauri system, antimatter propulsion would reduce one way trip time to 30 years or less. The challenges encountered by manned interstellar travel are formidable. The spacecraft must be a combination of sublight speed transportation system and a traveling microplanet serving an expanding population. As the population expands from the initial 100 people to approximately 300, the terraformed asteroid, enclosed by a man-made shell will allow for expansion over its surface in the fashion of a small terrestrial town. All aspects of human life - birth; death; physical, emotional, and educational needs; and government and law must be met by the structure, systems, and institutions on-board.

  7. Man and Nature, Resource Paper No. 10.

    ERIC Educational Resources Information Center

    Tuan, Yi-Fu

    Man and nature is the theme of this resource paper which is part of a series designed to supplement existing texts and to fill a gap between significant research in geography and readily accessible materials. The approach followed in the paper is loosely dialectical: the intent is to understand man and nature by posing one concept against the…

  8. Man and His Physical Environment: Teacher's Manual.

    ERIC Educational Resources Information Center

    Mank, Evans R.

    Building upon Course I, this teaching guide for the first of four units of Course II introduces the secondary student to geographic concepts and generalizations of the physical world to which man has related over time. All units of the second course emphasize the process of development whereby man, coping with given conditions in his physical…

  9. Diverse applications of advanced man-telerobot interfaces

    NASA Technical Reports Server (NTRS)

    Mcaffee, Douglas A.

    1991-01-01

    Advancements in man-machine interfaces and control technologies used in space telerobotics and teleoperators have potential application wherever human operators need to manipulate multi-dimensional spatial relationships. Bilateral six degree-of-freedom position and force cues exchanged between the user and a complex system can broaden and improve the effectiveness of several diverse man-machine interfaces.

  10. Ethology and Man

    ERIC Educational Resources Information Center

    Biology and Human Affairs, 1971

    1971-01-01

    Reviews four texts and compilations of papers in an effort to assess the relevance of animal behavior studies to anthropology and sociology. Concludes that where a basic element of behavior occurs widely throughout the animal kingdom, especially in the higher mammals and primates, we may expect to find a manifestation in man." Limitations of the…

  11. Eskimo Medicine Man.

    ERIC Educational Resources Information Center

    George, Otto

    "Eskimo Medicine Man" is a record of primitive Alaskan life in the 1930's. It records the experiences in Alaska's remote areas of Dr. Otto George, the last "traveling physician" for the Department of Interior's Indian Service, when in all the territory (an area one-fifth that of the contiguous United States) there were fewer…

  12. Implementation of a GPS-RO data processing system for the KIAPS-LETKF data assimilation system

    NASA Astrophysics Data System (ADS)

    Kwon, H.; Kang, J.-S.; Jo, Y.; Kang, J. H.

    2014-11-01

    The Korea Institute of Atmospheric Prediction Systems (KIAPS) has been developing a new global numerical weather prediction model and an advanced data assimilation system. As part of the KIAPS Package for Observation Processing (KPOP) system for data assimilation, preprocessing and quality control modules for bending angle measurements of global positioning system radio occultation (GPS-RO) data have been implemented and examined. GPS-RO data processing system is composed of several steps for checking observation locations, missing values, physical values for Earth radius of curvature, and geoid undulation. An observation-minus-background check is implemented by use of a one-dimensional observational bending angle operator and tangent point drift is also considered in the quality control process. We have tested GPS-RO observations utilized by the Korean Meteorological Administration (KMA) within KPOP, based on both the KMA global model and the National Center for Atmospheric Research (NCAR) Community Atmosphere Model-Spectral Element (CAM-SE) as a model background. Background fields from the CAM-SE model are incorporated for the preparation of assimilation experiments with the KIAPS-LETKF data assimilation system, which has been successfully implemented to a cubed-sphere model with fully unstructured quadrilateral meshes. As a result of data processing, the bending angle departure statistics between observation and background shows significant improvement. Also, the first experiment in assimilating GPS-RO bending angle resulting from KPOP within KIAPS-LETKF shows encouraging results.

  13. MO-AB-204-00: Interoperability in Radiation Oncology: IHE-RO Committee Update

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    You’ve experienced the frustration: vendor A’s device claims to work with vendor B’s device, but the practice doesn’t match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information. This is done by coordinating the use of published standardsmore » like DICOM and HL7. Several clinical and operational IHE domains exist in the healthcare arena, including Radiology and Radiation Oncology. The ASTRO-sponsored IHE Radiation Oncology (IHE-RO) domain focuses on radiation oncology specific information exchange. This session will explore the IHE Radiology and IHE RO process for; IHE solicitation process for new profiles. Improving the way computer systems interconnect and exchange information in the healthcare enterprise Supporting interconnectivity descriptions and proof of adherence by vendors Testing and assuring the vendor solutions to connectivity problems. Including IHE profiles in RFPs for future software and hardware purchases. Learning Objectives: Understand IHE role in improving interoperability in health care. Understand process of profile development and implantation. Understand how vendors prove adherence to IHE RO profiles. S. Hadley, ASTRO Supported Activity.« less

  14. The iRoCS Toolbox--3D analysis of the plant root apical meristem at cellular resolution.

    PubMed

    Schmidt, Thorsten; Pasternak, Taras; Liu, Kun; Blein, Thomas; Aubry-Hivet, Dorothée; Dovzhenko, Alexander; Duerr, Jasmin; Teale, William; Ditengou, Franck A; Burkhardt, Hans; Ronneberger, Olaf; Palme, Klaus

    2014-03-01

    To achieve a detailed understanding of processes in biological systems, cellular features must be quantified in the three-dimensional (3D) context of cells and organs. We described use of the intrinsic root coordinate system (iRoCS) as a reference model for the root apical meristem of plants. iRoCS enables direct and quantitative comparison between the root tips of plant populations at single-cell resolution. The iRoCS Toolbox automatically fits standardized coordinates to raw 3D image data. It detects nuclei or segments cells, automatically fits the coordinate system, and groups the nuclei/cells into the root's tissue layers. The division status of each nucleus may also be determined. The only manual step required is to mark the quiescent centre. All intermediate outputs may be refined if necessary. The ability to learn the visual appearance of nuclei by example allows the iRoCS Toolbox to be easily adapted to various phenotypes. The iRoCS Toolbox is provided as an open-source software package, licensed under the GNU General Public License, to make it accessible to a broad community. To demonstrate the power of the technique, we measured subtle changes in cell division patterns caused by modified auxin flux within the Arabidopsis thaliana root apical meristem. © 2014 The Authors The Plant Journal © 2014 John Wiley & Sons Ltd.

  15. Filming The Man Hunters

    ERIC Educational Resources Information Center

    Hockings, Paul

    1976-01-01

    "The Man Hunters" is a film about paleoanthropology. This article is a personal account of how the film was put together using anthropological knowledge and numerous anthropologists and how the film was received by the American public. (Author)

  16. Nuclear power--key to man's extraterrestrial civilization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Angelo, J.A.; Buden, D.

    1982-08-01

    The start of the Third Millennium will be highlighted by the establishment of man's extraterrestrial civilization with three technical cornerstones leading to the off-planet expansion of the human resource base. These are the availability of compact energy sources for power and propulsion, the creation of permanent manned habitats in space, and the ability to process materials anywhere in the Solar System. In the 1990s and beyond, nuclear reactors could represent the prime source of both space power and propulsion. The manned and unmanned space missions of tomorrow will demand first kilowatt and then megawatt levels of power. Various nuclear powermore » plant technologies are discussed, with emphasis on derivatives from the nuclear rocket technology.« less

  17. HD 50844: a new look at δ Scuti stars from CoRoT space photometry

    NASA Astrophysics Data System (ADS)

    Poretti, E.; Michel, E.; Garrido, R.; Lefèvre, L.; Mantegazza, L.; Rainer, M.; Rodríguez, E.; Uytterhoeven, K.; Amado, P. J.; Martín-Ruiz, S.; Moya, A.; Niemczura, E.; Suárez, J. C.; Zima, W.; Baglin, A.; Auvergne, M.; Baudin, F.; Catala, C.; Samadi, R.; Alvarez, M.; Mathias, P.; Paparò, M.; Pápics, P.; Plachy, E.

    2009-10-01

    Context: Aims: This work presents the results obtained by CoRoT on HD 50844, the only δ Sct star observed in the CoRoT initial run (57.6 d). The aim of these CoRoT observations was to investigate and characterize for the first time the pulsational behaviour of a δ Sct star, when observed at a level of precision and with a much better duty cycle than from the ground. Methods: The 140 016 datapoints were analysed using independent approaches (SigSpec software and different iterative sine-wave fittings) and several checks performed (splitting of the timeseries in different subsets, investigation of the residual light curves and spectra). A level of 10-5 mag was reached in the amplitude spectra of the CoRoT timeseries. The space monitoring was complemented by ground-based high-resolution spectroscopy, which allowed the mode identification of 30 terms. Results: The frequency analysis of the CoRoT timeseries revealed hundreds of terms in the frequency range 0-30 d-1. All the cross-checks confirmed this new result. The initial guess that δ Sct stars have a very rich frequency content is confirmed. The spectroscopic mode identification gives theoretical support since very high-degree modes (up to ℓ=14) are identified. We also prove that cancellation effects are not sufficient in removing the flux variations associated to these modes at the noise level of the CoRoT measurements. The ground-based observations indicate that HD 50844 is an evolved star that is slightly underabundant in heavy elements, located on the Terminal Age Main Sequence. Probably due to this unfavourable evolutionary status, no clear regular distribution is observed in the frequency set. The predominant term (f_1=6.92 d-1) has been identified as the fundamental radial mode combining ground-based photometric and spectroscopic data. Conclusions: The CoRoT space mission was developed and is operated by the French space agency CNES, with participation of ESA's RSSD and Science Programmes, Austria

  18. Thermal protection systems manned spacecraft flight experience

    NASA Technical Reports Server (NTRS)

    Curry, Donald M.

    1992-01-01

    Since the first U.S. manned entry, Mercury (May 5, 1961), seventy-five manned entries have been made resulting in significant progress in the understanding and development of Thermal Protection Systems (TPS) for manned rated spacecraft. The TPS materials and systems installed on these spacecraft are compared. The first three vehicles (Mercury, Gemini, Apollo) used ablative (single-use) systems while the Space Shuttle Orbiter TPS is a multimission system. A TPS figure of merit, unit weight lb/sq ft, illustrates the advances in TPS material performance from Mercury (10.2 lb/sq ft) to the Space Shuttle (1.7 lb/sq ft). Significant advances have been made in the design, fabrication, and certification of TPS on manned entry vehicles (Mercury through Shuttle Orbiter). Shuttle experience has identified some key design and operational issues. State-of-the-art ceramic insulation materials developed in the 1970's for the Space Shuttle Orbiter have been used in the initial designs of aerobrakes. This TPS material experience has identified the need to develop a technology base from which a new class of higher temperature materials will emerge for advanced space transportation vehicles.

  19. Space station support of manned Mars missions

    NASA Technical Reports Server (NTRS)

    Holt, Alan C.

    1986-01-01

    The assembly of a manned Mars interplanetary spacecraft in low Earth orbit can be best accomplished with the support of the space station. Station payload requirements for microgravity environments of .001 g and pointing stability requirements of less than 1 arc second could mean that the spacecraft may have to be assembled at a station-keeping position about 100 meters or more away from the station. In addition to the assembly of large modules and connective structures, the manned Mars mission assembly tasks may include the connection of power, fluid, and data lines and the handling and activation of components for chemical or nuclear power and propulsion systems. These assembly tasks will require the use of advanced automation and robotics in addition to Orbital Maneuvering Vehicle and Extravehicular Activity (EVA) crew support. Advanced development programs for the space station, including on-orbit demonstrations, could also be used to support manned Mars mission technology objectives. Follow-on studies should be conducted to identify space station activities which could be enhanced or expanded in scope (without significant cost and schedule impact) to help resolve key technical and scientific questions relating to manned Mars missions.

  20. A Rich Man, Poor Man Story of S-Adenosylmethionine and Cobalamin Revisited.

    PubMed

    Bridwell-Rabb, Jennifer; Grell, Tsehai A J; Drennan, Catherine L

    2018-06-20

    S-adenosylmethionine (AdoMet) has been referred to as both "a poor man's adenosylcobalamin (AdoCbl)" and "a rich man's AdoCbl," but today, with the ever-increasing number of functions attributed to each cofactor, both appear equally rich and surprising. The recent characterization of an organometallic species in an AdoMet radical enzyme suggests that the line that differentiates them in nature will be constantly challenged. Here, we compare and contrast AdoMet and cobalamin (Cbl) and consider why Cbl-dependent AdoMet radical enzymes require two cofactors that are so similar in their reactivity. We further carry out structural comparisons employing the recently determined crystal structure of oxetanocin-A biosynthetic enzyme OxsB, the first three-dimensional structural data on a Cbl-dependent AdoMet radical enzyme. We find that the structural motifs responsible for housing the AdoMet radical machinery are largely conserved, whereas the motifs responsible for binding additional cofactors are much more varied.

  1. RoMPS concept review automatic control of space robot, volume 2

    NASA Technical Reports Server (NTRS)

    Dobbs, M. E.

    1991-01-01

    Topics related to robot operated materials processing in space (RoMPS) are presented in view graph form and include: (1) system concept; (2) Hitchhiker Interface Requirements; (3) robot axis control concepts; (4) Autonomous Experiment Management System; (5) Zymate Robot Controller; (6) Southwest SC-4 Computer; (7) oven control housekeeping data; and (8) power distribution.

  2. Characterization and biotoxicity assessment of dissolved organic matter in RO concentrate from a municipal wastewater reclamation reverse osmosis system.

    PubMed

    Sun, Ying-Xue; Gao, Yue; Hu, Hong-Ying; Tang, Fang; Yang, Zhe

    2014-12-01

    Reverse osmosis (RO) concentrate from municipal wastewater reclamation reverse osmosis (mWRRO) system containing organic compounds may associate with toxic risk, and its discharge might pose an environmental risk. To identify a basis for the selection of feasible technology in treating RO concentrates, the characteristics and biotoxicity of different fractions of dissolved organic matter (DOM) in RO concentrates from an mWRRO system were investigated. The results indicated that the hydrophilic neutrals (HIN), hydrophobic acids (HOA) and hydrophobic bases (HOB) accounted for 96% of the dissolved organic carbon (DOC) of the total DOM in the RO concentrate. According to the SEC chromatograph detected at 254 nm wavelength of UV, the DOM with molecular weight (MW) 1-3 kDa accounted for the majority of the basic and neutral fractions. The fluorescence spectra of the excitation emission matrix (EEM) indicated that most aromatic proteins, humic/fulvic acid-like and soluble microbial by-product-like substances existed in the fractions HOA and hydrophobic neutrals (HON). The genotoxicity and anti-estrogenic activity of the RO concentrate were 1795.6 ± 57.2 μg 4-NQOL(-1) and 2.19 ± 0.05 mg TAM L(-1), respectively. The HIN, HOA, and HOB contributed to the genotoxicity of the RO concentrate, and the HIN was with the highest genotoxic level of 1007.9 ± 94.8 μg 4-NQOL(-1). The HOA, HON, and HIN lead to the total anti-estrogenic activity of the RO concentrate, and HOA occupied approximately 60% of the total, which was 1.3 ± 0.17 mg TAM L(-1). Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Understanding nuclear motions in molecules: Derivation of Eckart frame ro-vibrational Hamiltonian operators via a gateway Hamiltonian operator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Szalay, Viktor, E-mail: szalay.viktor@wigner.mta.hu

    A new ro-vibrational Hamiltonian operator, named gateway Hamiltonian operator, with exact kinetic energy term, T-hat, is presented. It is in the Eckart frame and it is of the same form as Watson’s normal coordinate Hamiltonian. However, the vibrational coordinates employed are not normal coordinates. The new Hamiltonian is shown to provide easy access to Eckart frame ro-vibrational Hamiltonians with exact T-hat given in terms of any desired set of vibrational coordinates. A general expression of the Eckart frame ro-vibrational Hamiltonian operator is given and some of its properties are discussed.

  4. Computational molecular spectroscopy of X ˜ 2 Π NCS: Electronic properties and ro-vibrationally averaged structure

    NASA Astrophysics Data System (ADS)

    Hirano, Tsuneo; Nagashima, Umpei; Jensen, Per

    2018-04-01

    For NCS in the X ˜ 2 Π electronic ground state, three-dimensional potential energy surfaces (3D PESs) have been calculated ab initio at the core-valence, full-valence MR-SDCI+Q/[aug-cc-pCVQZ (N, C, S)] level of theory. The ab initio 3D PESs are employed in second-order-perturbation-theory and DVR3D calculations to obtain various molecular constants and ro-vibrationally averaged structures. The 3D PESs show that the X ˜ 2 Π NCS has its potential minimum at a linear configuration, and hence it is a "linear molecule." The equilibrium structure has re (N-C) = 1.1778 Å, re (C-S) = 1.6335 Å, and ∠e (N-C-S) = 180°. The ro-vibrationally averaged structure, determined as expectation values over DVR3D wavefunctions, has 〈 r (N-C)〉0 = 1.1836 Å, 〈 r (C-S)〉0 = 1.6356 Å, and 〈 ∠ (N-C-S)〉0 = 172.5°. Using these expectation values as the initial guess, a bent r0 structure having an 〈 ∠ (N-C-S)〉0 of 172.2° is deduced from the experimentally reported B0 values for NC32S and NC34S. Our previous prediction that a linear molecule, in any ro-vibrational state including the ro-vibrational ground state, is to be "observed" as being bent on ro-vibrational average, has been confirmed here theoretically through the expectation value for the bond-angle deviation from linearity, 〈 ρ bar 〉 , and experimentally through the interpretation of the experimentally derived rotational-constant values.

  5. Implementation of a GPS-RO data processing system for the KIAPS-LETKF data assimilation system

    NASA Astrophysics Data System (ADS)

    Kwon, H.; Kang, J.-S.; Jo, Y.; Kang, J. H.

    2015-03-01

    The Korea Institute of Atmospheric Prediction Systems (KIAPS) has been developing a new global numerical weather prediction model and an advanced data assimilation system. As part of the KIAPS package for observation processing (KPOP) system for data assimilation, preprocessing, and quality control modules for bending-angle measurements of global positioning system radio occultation (GPS-RO) data have been implemented and examined. The GPS-RO data processing system is composed of several steps for checking observation locations, missing values, physical values for Earth radius of curvature, and geoid undulation. An observation-minus-background check is implemented by use of a one-dimensional observational bending-angle operator, and tangent point drift is also considered in the quality control process. We have tested GPS-RO observations utilized by the Korean Meteorological Administration (KMA) within KPOP, based on both the KMA global model and the National Center for Atmospheric Research Community Atmosphere Model with Spectral Element dynamical core (CAM-SE) as a model background. Background fields from the CAM-SE model are incorporated for the preparation of assimilation experiments with the KIAPS local ensemble transform Kalman filter (LETKF) data assimilation system, which has been successfully implemented to a cubed-sphere model with unstructured quadrilateral meshes. As a result of data processing, the bending-angle departure statistics between observation and background show significant improvement. Also, the first experiment in assimilating GPS-RO bending angle from KPOP within KIAPS-LETKF shows encouraging results.

  6. Space Station man-machine automation trade-off analysis

    NASA Technical Reports Server (NTRS)

    Zimmerman, W. F.; Bard, J.; Feinberg, A.

    1985-01-01

    The man machine automation tradeoff methodology presented is of four research tasks comprising the autonomous spacecraft system technology (ASST) project. ASST was established to identify and study system level design problems for autonomous spacecraft. Using the Space Station as an example spacecraft system requiring a certain level of autonomous control, a system level, man machine automation tradeoff methodology is presented that: (1) optimizes man machine mixes for different ground and on orbit crew functions subject to cost, safety, weight, power, and reliability constraints, and (2) plots the best incorporation plan for new, emerging technologies by weighing cost, relative availability, reliability, safety, importance to out year missions, and ease of retrofit. A fairly straightforward approach is taken by the methodology to valuing human productivity, it is still sensitive to the important subtleties associated with designing a well integrated, man machine system. These subtleties include considerations such as crew preference to retain certain spacecraft control functions; or valuing human integration/decision capabilities over equivalent hardware/software where appropriate.

  7. Translations on North Korea, Number 546.

    DTIC Science & Technology

    1977-08-26

    Comrade Ho Tam " Kye Ung -t’ae " Pak Yong -sok Functionary of the sector concerned Yi Ch’ang-son " Chon In-ch’ol " [Pyongyang NODONG SINMUN in Korean 14...functionary of the sector concerned Kim Tu- yong . [Pyongyang NODONG SINMUN in Korean 15 Jun 77 p 2] ARAB DELEGATION WELCOME—The following participated...Hwa-son . Functionary of the sector concerned Kim Yong -sun " [Pyongyang NODONG SINMUN in Korean 15 Jun 77 p 3] ARAB DELEGATION BANQUET—Attending a

  8. Korean Affairs Report

    DTIC Science & Technology

    1986-03-26

    with the "outrageous" measures recently taken by the police to block its headquarters, Floor leader Kim Tong- yong of the party said that he expects the... Kims on the party as a precondition, is too wide. In the wake of his recent meetings with Kim Yong -sam, Yi Min-u, and Kim Sang- hyon, Cho is...Initial police investigation showed that Yi was hit by a 50cm-long wooden bar carried by Yim Yong -chol, 23, a junior. Police apprehended Yim, Miss Kim

  9. 10 CFR 72.94 - Design basis external man-induced events.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Design basis external man-induced events. 72.94 Section 72... WASTE Siting Evaluation Factors § 72.94 Design basis external man-induced events. (a) The region must be examined for both past and present man-made facilities and activities that might endanger the proposed...

  10. 10 CFR 72.94 - Design basis external man-induced events.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Design basis external man-induced events. 72.94 Section 72... WASTE Siting Evaluation Factors § 72.94 Design basis external man-induced events. (a) The region must be examined for both past and present man-made facilities and activities that might endanger the proposed...

  11. 10 CFR 72.94 - Design basis external man-induced events.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Design basis external man-induced events. 72.94 Section 72... WASTE Siting Evaluation Factors § 72.94 Design basis external man-induced events. (a) The region must be examined for both past and present man-made facilities and activities that might endanger the proposed...

  12. 10 CFR 72.94 - Design basis external man-induced events.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Design basis external man-induced events. 72.94 Section 72... WASTE Siting Evaluation Factors § 72.94 Design basis external man-induced events. (a) The region must be examined for both past and present man-made facilities and activities that might endanger the proposed...

  13. RenderMan design principles

    NASA Technical Reports Server (NTRS)

    Apodaca, Tony; Porter, Tom

    1989-01-01

    The two worlds of interactive graphics and realistic graphics have remained separate. Fast graphics hardware runs simple algorithms and generates simple looking images. Photorealistic image synthesis software runs slowly on large expensive computers. The time has come for these two branches of computer graphics to merge. The speed and expense of graphics hardware is no longer the barrier to the wide acceptance of photorealism. There is every reason to believe that high quality image synthesis will become a standard capability of every graphics machine, from superworkstation to personal computer. The significant barrier has been the lack of a common language, an agreed-upon set of terms and conditions, for 3-D modeling systems to talk to 3-D rendering systems for computing an accurate rendition of that scene. Pixar has introduced RenderMan to serve as that common language. RenderMan, specifically the extensibility it offers in shading calculations, is discussed.

  14. Study of Pulsations in the Atmosphere of the roAp star HD 137949

    NASA Astrophysics Data System (ADS)

    Sachkov, M.; Hareter, M.; Ryabchikova, T.; Wade, G.; Kochukhov, O.; Weiss, W. W.

    The roAp star HD 137949 (33 Lib) shows the most complex pulsational behaviour among all roAp stars. Mkrtichian et al. (2003) found nearly anti-phase pulsations of Nd II and Nd III lines, which they attribute to the presence of a pulsation node high in the atmosphere of HD 137949. This was confirmed by Kurtz at al. (2005), who also find that in some REE lines the main frequency, corresponding to 8.27 min, and its harmonic have almost equal RV amplitudes. Based on high accuracy observations Ryabchikova et al. (2007a) studied pulsational characteristics of the HD 137949 atmosphere in detail. In general, spectroscopy provides 3D resolution of modes and allows to search for the photometrically undetectable frequencies. The high-accuracy space photometry provides very high-precision measurements of detected pulsation frequencies and enables an accurate phasing of multi-site spectroscopic data. A combination of simultaneous spectroscopy and photometry represents the most sophisticated asteroseismic dataset for any roAp star. In 2009 the star HD 137949 became a target of an intense observing campaign that combined ground-based spectroscopy with space photometry, obtained with the MOST satellite. We collected 780 spectra using the ESPaDOnS spectrograph mounted on the 3.6 m CFHT telescope; 374 spectra were obtained with the FIES spectrograph mounted on the 2.56-m NOT to perform the time-resolved spectroscopy of HD 137949. In addition, we used 111 UVES spectra (2004) from the ESO archive to check the mode stability. The frequency analysis of the new radial velocity (RV) measurements confirmed the previously reported frequency pattern (two frequencies and the first harmonic of the main frequency), and revealed an additional frequency at 1.991 mHz. The new frequency solution fits perfectly the RV variations from the 2004 and 2009 observational sets providing a strong support for the p-mode stability in the roAp star HD 137949 for at least 5 years.

  15. Landing A Man Downtown

    ERIC Educational Resources Information Center

    Waters, W. G., II

    1973-01-01

    Analyzes the urban transport problems in comparison with those involved in a journey to the Moon. Indicates that the problem of enabling man to travel through the inner space of conurbations may prove to be more difficult than the transport problem of space travel. (CC)

  16. Sexual Harassment and Manly Sports: Are They Related?

    ERIC Educational Resources Information Center

    Murolo, Nancy Maurer; Schmelkin, Liora Pedhazur

    This study investigates the relationship between sexual harassment and participation in "manly" sports (i.e., football, baseball, basketball, soccer, and wrestling) at the high school level. Manly sports are defined as those sports that celebrate values of dominance, aggression, male solidarity, and female exclusion. Participants were 353 11th-…

  17. Manned remote work station development article, executive summary

    NASA Technical Reports Server (NTRS)

    1979-01-01

    The mission requirements for the manned remote work station (MRWS) flight article and the manned remote work station open cherry picker development test article is defined. Considerations are given for the near, mid, and far term use of the MRWS with emphasis on its ultimate application: constructing the Solar Power Satellite.

  18. Man in the age of technology.

    PubMed

    Galimberti, Umberto

    2009-02-01

    This paper argues that technology is no longer merely a tool for man's use but has become the environment in which man undergoes modifications. The author traces the role of technology from the Greeks to the present day. For the Greeks, Nature was governed by necessity and therefore unchangeable whereas in the Judeo-Christian tradition, nature was entrusted to man for him to dominate. Modern science studies the world in order to manipulate and dominate nature through the use of technology which has now become an end in itself, governing the solution of political problems and confronting us with problems beyond our competence to resolve. The ethical impact of technology has been to create a change from 'acting' which assumes responsibility for one's actions to 'doing' which is concerned only with the effective execution of a 'job' without concern for the wider consequences. It can no longer be argued that technology is good or bad according to the use we make of it since technology now makes use of us and thus transforms our ethics, social relationships and psychological being.

  19. Evaluation of an MBR-RO system to produce high quality reuse water: microbial control, DBP formation and nitrate.

    PubMed

    Comerton, Anna M; Andrews, Robert C; Bagley, David M

    2005-10-01

    A membrane bioreactor and reverse osmosis (MBR-RO) system was developed to assess potential reuse applications of municipal wastewater. The objective of the study was to examine the water quality throughout the system with a focus on waterborne pathogens, disinfection by-products (DBPs) and nitrate. This paper will discuss the presence of these contaminants in MBR effluent and focus on their subsequent removal by RO. This study has shown that high quality reuse water can be produced from municipal wastewater through the use of an MBR-RO system. The water meets California Title 22 reuse regulations for non-potable applications and US EPA drinking water limits for trihalomethanes (THM) (80 microg/L), haloacetic acids (HAA) (60 microg/L), chlorite (1.0 mg/L), total coliform (not detectable), viruses (not detectable), and nitrate/nitrite (10 mg N/L). However, THM formation (182-689 microg/L) attributed to cleaning of the MBR with chlorine and incomplete removal by subsequent RO treatment resulted in reuse water with THM levels (40.2+/-19.9 microg/L) high enough to present a potential concern when considering drinking water applications. Nitrate levels of up to 3.6 mg N/L, which resulted from incomplete removal by the RO membrane, are also a potential concern. A denitrification step in the MBR should be considered in potable water applications.

  20. 42 CFR 84.103 - Man tests; performance requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Man tests; performance requirements. 84.103 Section 84.103 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self-Contained Breathing Apparatus § 84.103 Man tests;...

  1. 42 CFR 84.101 - Man test 5; requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Man test 5; requirements. 84.101 Section 84.101 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND... Breathing Apparatus § 84.101 Man test 5; requirements. (a) Test 5 will be conducted to determine the maximum...

  2. 42 CFR 84.101 - Man test 5; requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Man test 5; requirements. 84.101 Section 84.101 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND... Breathing Apparatus § 84.101 Man test 5; requirements. (a) Test 5 will be conducted to determine the maximum...

  3. 42 CFR 84.101 - Man test 5; requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Man test 5; requirements. 84.101 Section 84.101 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND... Breathing Apparatus § 84.101 Man test 5; requirements. (a) Test 5 will be conducted to determine the maximum...

  4. Translations on North Korea No. 495

    DTIC Science & Technology

    1976-12-02

    Yun Ch’i-ho Hwang Ch’ol-san Kim Yong -yon comrade, KPA general, political committee member, and DPRK minister of peoples armed forces colonel...t’ae " So Kwan-hi functionary of the sector concerned Chong Song-nam Kim Sok-chin So Nam-sin Han Pyong- yong Wang Kyong-hak Ch’oe Sang-muk...Chin-t’ae Kim Sok-ki Yi Chong-mok Ch’oe Tu-kwang Han Su-kil Yi Yong -ch’ang [Pyongyang NODONG SINMUN in Korean 8 Oct 76 p 3] LOYALTY OATH

  5. SPEECH--MAN'S NATURAL COMMUNICATION.

    ERIC Educational Resources Information Center

    DUDLEY, HOMER; AND OTHERS

    SESSION 63 OF THE 1967 INSTITUTE OF ELECTRICAL AND ELECTRONIC ENGINEERS INTERNATIONAL CONVENTION BROUGHT TOGETHER SEVEN DISTINGUISHED MEN WORKING IN FIELDS RELEVANT TO LANGUAGE. THEIR TOPICS INCLUDED ORIGIN AND EVOLUTION OF SPEECH AND LANGUAGE, LANGUAGE AND CULTURE, MAN'S PHYSIOLOGICAL MECHANISMS FOR SPEECH, LINGUISTICS, AND TECHNOLOGY AND…

  6. Man-Made Climatic Changes

    ERIC Educational Resources Information Center

    Landsberg, Helmut E.

    1970-01-01

    Reviews environmental studies which show that national climatic fluctuations vary over a wide range. Solar radiation, earth temperatures, precipitation, atmospheric gases and suspended particulates are discussed in relation to urban and extraurban effects. Local weather modifications and attempts at climate control by man seem to have substantial…

  7. Manned Mars Mission program concepts

    NASA Technical Reports Server (NTRS)

    Hamilton, E. C.; Johnson, P.; Pearson, J.; Tucker, W.

    1988-01-01

    This paper describes the SRS Manned Mars Mission and Program Analysis study designed to support a manned expedition to Mars contemplated by NASA for the purposes of initiating human exploration and eventual habitation of this planet. The capabilities of the interactive software package being presently developed by the SRS for the mission/program analysis are described, and it is shown that the interactive package can be used to investigate the impact of various mission concepts on the sensitivity of mass required in LEO, schedules, relative costs, and risk. The results, to date, indicate the need for an earth-to-orbit transportation system much larger than the present STS, reliable long-life support systems, and either advanced propulsion or aerobraking technology.

  8. Human factors - Man-machine symbiosis in space

    NASA Technical Reports Server (NTRS)

    Brown, Jeri W.

    1987-01-01

    The relation between man and machine in space is studied. Early spaceflight and the goal of establishing a permanent space presence are described. The need to consider the physiological, psychological, and social integration of humans for each space mission is examined. Human factors must also be considered in the design of spacecraft. The effective utilization of man and machine capabilities, and research in anthropometry and biomechanics aimed at determining the limitations of spacecrews are discussed.

  9. [Knowledge of Man Returns: Some Considerations on Spirituality and Resilience].

    PubMed

    Kumakura, Nobuhiro

    2015-01-01

    Over the last decade,"spirituality" and "resilience" have jointly become a topic in psychiatry. The aim of this paper is to discuss the future of psychiatry suggested by this topic. It may be related to what Jaspers, K. called "Knowledge of Man (die Erkenntnis des Menschen)". Knowledge of man in psychiatry can be learned only through clinical experince: e. g., clinical observations and case studies. Modern academic psychiatry seems to be suffering a loss of knowledge of man, which returns periodically in clinical practice. Hence, I will call the re-discovery of the topic in psychiatry as "Return of Man". Since WW II, there have been three eras in which psychiatrists showed deep concern regarding knowledge of man. Firstly, psychopathology and psychotherapy widely developed, when the destructive impulses of mankind were revealed in the nuclear weapons of WW II. Secondly, in the 1970's, the reforms of psychiatric services and legal systems took place somewhat successfully, when social reforms were concerns of the younger generations. Lastly, over the last decade, the topic again returned as spirituality and resilience, when scientists seemed to be powerless in the aftermath of the West Japan Earthquake. Regarding the definition of health made by the WHO in 1946, I further discuss that "Return of Man" in psychiatry is the necessary dynamism between negative and positive health, or between disease control and health promotion. There is an underlying dynamism between "Knowledge of Man" and natural sciences, which is constantly changing. So long as any theory can exist only as a part of dynamism, the Return of Man may re-surface whenever clinical theories do not fit with clinical realities.

  10. 42 CFR 84.102 - Man test 6; requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Man test 6; requirements. 84.102 Section 84.102 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self-Contained Breathing Apparatus § 84.102 Man test 6; requirements....

  11. 42 CFR 84.101 - Man test 5; requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Man test 5; requirements. 84.101 Section 84.101 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self-Contained Breathing Apparatus § 84.101 Man test 5; requirements....

  12. Models of red giants in the CoRoT asteroseismology fields combining asteroseismic and spectroscopic constraints

    NASA Astrophysics Data System (ADS)

    Nadège, Lagarde

    The availability of asteroseismic constraints for a large sample of red-giant stars from the CoRoT and Kepler missions paves the way for various statistical studies of the seismic properties of stellar populations. We use a detailed spectroscopic study of 19 CoRoT red-giant stars (Morel et al. 2014) to compare theoretical stellar evolution models to observations of the open cluster NGC 6633 and field stars. This study is already published in Lagarde et al. (2015)

  13. VizieR Online Data Catalog: Spectral types of stars in CoRoT fields (Sebastian+, 2012)

    NASA Astrophysics Data System (ADS)

    Sebastian, D.; Guenther, E. W.; Schaffenroth, V.; Gandolfi, D.; Geier, S.; Heber, U.; Deleuil, M.; Moutou, C.

    2012-03-01

    Spectroscopic classification for 2950 O-, B-, and A-type stars in the CoRoT-fields IRa01, LRa01, and LRa02. Stars are named by their CoRoT-identifier and Coordinates are given. The visual magnitudes were obtained with the Wide Field Camera filter-system of the Isaac Newton Telescope at Roque de los Muchachos Observatory on La Palma and can be converted into Landolt standards, as shown in Deleuil et al. (2009AJ....138..649D). (1 data file).

  14. Manned Space Exploration Can Provide Great Scientific Benefits

    NASA Astrophysics Data System (ADS)

    Singer, S. Fred

    2005-08-01

    An AGU Council statement (NASA: Earth and space sciences at risk, available at http:// www.agu.org/sci_soc/policy/positions/ earthspace_risk.shtml) and an Eos editorial [Barron, 2005], addressing NASA's envisioned manned Moon-Mars initiative, implicitly assume a zero-sum situation between manned and unmanned space programs. They also imply that the NASA initiative will not contribute significantly to science but will ``impact on the current and future health of Earth and space science research.'' I wish to respond to these concerns. It is generally agreed that the International Space Station and shuttle program have limited value and need to be terminated. But one should not assume that funds freed up by elimination of manned programs will accrue to unmanned programs. On the contrary, without a manned component, NASA will probably cease to exist. Congress likely will not continue to fund unmanned planetary exploration over the long term, and Earth and space researchers will then have to compete for support with scientists using non-space techniques.

  15. Small reactor power systems for manned planetary surface bases

    NASA Technical Reports Server (NTRS)

    Bloomfield, Harvey S.

    1987-01-01

    A preliminary feasibility study of the potential application of small nuclear reactor space power systems to manned planetary surface base missions was conducted. The purpose of the study was to identify and assess the technology, performance, and safety issues associated with integration of reactor power systems with an evolutionary manned planetary surface exploration scenario. The requirements and characteristics of a variety of human-rated modular reactor power system configurations selected for a range of power levels from 25 kWe to hundreds of kilowatts is described. Trade-off analyses for reactor power systems utilizing both man-made and indigenous shielding materials are provided to examine performance, installation and operational safety feasibility issues. The results of this study have confirmed the preliminary feasibility of a wide variety of small reactor power plant configurations for growth oriented manned planetary surface exploration missions. The capability for power level growth with increasing manned presence, while maintaining safe radiation levels, was favorably assessed for nominal 25 to 100 kWe modular configurations. No feasibility limitations or technical barriers were identified and the use of both distance and indigenous planetary soil material for human rated radiation shielding were shown to be viable and attractive options.

  16. Man-Machine Communication Research.

    DTIC Science & Technology

    1977-02-01

    communication difficulty for the computer-naive; discovery of major communication structures in human communication that have been left out of man-machine...processes; creation of a new overview of how human communication functions in cooperative task-oriented activity; and assistance in ARPA policy formation on CAI equipment development.

  17. Emblem - Third (3rd) Manned Skylab (SL) Mission - SL-4

    NASA Image and Video Library

    1972-11-14

    S72-53094 (For release February 1973) --- This is the emblem for the third manned Skylab mission. It will be a mission of up to 56 days. Skylab is an experimental space station consisting of a 100-ton laboratory complex in which medical, scientific and technological experiments will be performed in Earth orbit. The members of the crew will be astronaut Gerald P. Carr, commander; scientist-astronaut Edward G. Gibson, science pilot; and astronaut William R. Pogue, pilot. The symbols in the patch refer to the three major areas of investigation proposed in the mission. The tree represents man's natural environment and relates directly to the Skylab mission objectives of advancing the study of Earth resources. The hydrogen atom, as the basic building block of the universe, represents man's exploration of the physical world, his application of knowledge, and his development of technology. Since the sun is composed primarily of hydrogen, it is appropriate that the symbol refers to the solar physics mission objectives. The human silhouette represents mankind and the human capacity to direct technology with a wisdom tempered by regard for his natural environment. It also directly relates to the Skylab medical studies of man himself. The rainbow, adopted from the Biblical story of the flood, symbolizes the promise that is offered man. It embraces man and extends to the tree and the hydrogen atom emphasizing man's pivotal role in the conciliation of technology with nature. Photo credit: NASA

  18. The nociceptin/orphanin FQ receptor agonist Ro 64-6198 reduces alcohol self-administration and prevents relapse-like alcohol drinking.

    PubMed

    Kuzmin, Alexander; Kreek, Mary Jeanne; Bakalkin, Georgy; Liljequist, Sture

    2007-04-01

    Effects of the opioid receptor like-1 (ORL-1) receptor agonist Ro 64-6198 (0.1, 0.3, and 1.0 mg/kg intraperitoneally (i.p.)) on operant ethanol self-administration and activation of self-administration by ethanol deprivation were studied in male Wistar rats. Acute administration of Ro 64-6198 caused a dose-dependent reduction of ethanol self-administration. In comparison, the opioid antagonist naltrexone (0.1, 0.3, and 1.0 mg/kg i.p.) inhibited ethanol self-administration at all doses tested. Ethanol deprivation for 10 days significantly increased ethanol self-administration during the first 2 days after deprivation. Daily pretreatment with Ro 64-6198 (0.3 mg/kg) or naltrexone (0.3 mg/kg) during the last 3 days of ethanol deprivation abolished the deprivation-induced increase in ethanol intake. Thus, stimulation of the ORL-1 receptors by Ro 64-6198 reduced the acute reinforcing effects of ethanol and prevented relapse-like behavior in the ethanol-deprivation model in a similar manner as a blockade of opioid receptors by naltrexone. Ro 64-6198 at 0.1 and 0.3 mg/kg doses did not alter self-administration of 0.2% saccharin solution, indicating an apparent selectivity of this compound in modification of ethanol reward. These findings add further support to the idea that Ro 64-6198 and potentially other synthetic ORL-1 receptor agonists are as effective as naltrexone in blocking the actions of ethanol important for its addictive potential in animal experiments, and therefore may have therapeutic value in the treatment of alcoholism.

  19. Special cascade LMS equalization scheme suitable for 60-GHz RoF transmission system.

    PubMed

    Liu, Siming; Shen, Guansheng; Kou, Yanbin; Tian, Huiping

    2016-05-16

    We design a specific cascade least mean square (LMS) equalizer and to the best of our knowledge, it is the first time this kind of equalizer has been employed for 60-GHz millimeter-wave (mm-wave) radio over fiber (RoF) system. The proposed cascade LMS equalizer consists of two sub-equalizers which are designated for optical and wireless channel compensations, respectively. We control the linear and nonlinear factors originated from optical link and wireless link separately. The cascade equalization scheme can keep the nonlinear distortions of the RoF system in a low degree. We theoretically and experimentally investigate the parameters of the two sub-equalizers to reach their best performances. The experiment results show that the cascade equalization scheme has a faster convergence speed. It needs a training sequence with a length of 10000 to reach its stable status, which is only half as long as the traditional LMS equalizer needs. With the utility of a proposed equalizer, the 60-GHz RoF system can successfully transmit 5-Gbps BPSK signal over 10-km fiber and 1.2-m wireless link under forward error correction (FEC) limit 10-3. An improvement of 4dBm and 1dBm in power sensitivity at BER 10-3 over traditional LMS equalizer can be observed when the signals are transmitted through Back-to-Back (BTB) and 10-km fiber 1.2-m wireless links, respectively.

  20. Removal of bisphenol A (BPA) from water by various nanofiltration (NF) and reverse osmosis (RO) membranes.

    PubMed

    Yüksel, Suna; Kabay, Nalan; Yüksel, Mithat

    2013-12-15

    The removal of an endocrine disrupting compound, bisphenol A (BPA), from model solutions by selected nanofiltration (NF) and reverse osmosis (RO) membranes was studied. The commercially available membranes NF 90, NF 270, XLE BWRO, BW 30 (Dow FilmTech), CE BWRO and AD SWRO (GE Osmonics) were used to compare their performances for BPA removal. The water permeability coefficients, rejection of BPA and permeate flux values were calculated for all membranes used. No significant changes in their BPA removal were observed for all tight polyamide based NF and RO membranes tested except for loose NF 270 membrane. The polyamide based membranes exhibited much better performance than cellulose acetate membrane for BPA removal. Almost a complete rejection (≥ 98%) for BPA was obtained with three polyamide based RO membranes (BW 30, XLE BWRO and AD SWRO). But cellulose acetate based CE BWRO membrane offered a low and variable (10-40%) rejection for BPA. Copyright © 2013 Elsevier B.V. All rights reserved.

  1. Crystallization and preliminary X-ray analysis of the Man(α1-2)Man-specific lectin from Bowringia mildbraedii in complex with its carbohydrate ligand

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Garcia-Pino, Abel; Loris, Remy; Wyns, Lode

    2005-10-01

    The lectin from the Nigerian legume B. mildbraedii was crystallized in complex with Man(α1-2)Man and data were collected to a resolution of 1.90 Å using synchrotron radiation. The lectin from Bowringia mildbraedii seeds crystallizes in the presence of the disaccharide Man(α1-2)Man. The best crystals grow at 293 K within four weeks after a pre-incubation at 277 K to induce nucleation. A complete data set was collected to a resolution of 1.90 Å using synchrotron radiation. The crystals belong to space group I222, with unit-cell parameters a = 66.06, b = 86.35, c = 91.76 Å, and contain one lectin monomermore » in the asymmetric unit.« less

  2. Five Years of the RoBOT "Rocks Beneath Our Toes" High School Outreach Program

    NASA Astrophysics Data System (ADS)

    Baxter, E. F.

    2011-12-01

    The "Rocks Beneath Our Toes" or RoBOT Program began in 2006 as part of an NSF CAREER award through the Geochemistry and Petrology Program. The educational outreach program engages Boston area high school students in a hands on study of rocks and minerals collected in their communities. The goal is to provide high school students a unique window into modern scientific methods of geochemistry and mineralogy and create a higher level of interest and awareness of geoscience amongst Massachusetts secondary school students who are less often exposed to earth science coursework. Beginning with a joint field trip to sampling sites identified by participants, high school students work with Boston University undergraduates enrolled in Mineralogy to analyze their samples in thin section. During the field trip, each BU undergraduate is paired with a high school student. The assignment of student pairings (started in year 2) dramatically increased student interactions and enjoyment. The program culminates with a visit by the high school group to tour BU's lab facilities and work with the undergraduates using the petrographic microscopes to explore their rock. At this visit, BU undergraduates present their semester's work in one-on-one powerpoint presentations from which discussion and microscope work follow. Thus far, >50 high school students, >40 undergraduates, and 7 high school educators were involved in the program. This included participants from three different suburban Boston area high schools and with students enrolled in the BU "Upward Bound" program: an existing program designed to enhance educational opportunities for Boston inner city high school students. Participant reviews indicate great success in achieving the program's goals. Notably, both BU undergraduates and high school students rated the opportunities for interaction with eachother among the best aspects of RoBOT. On a scale of 1 to 10, BU undergraduates rated the following four categories highest

  3. Combination of cupric ion with hydroxylamine and hydrogen peroxide for the control of bacterial biofilms on RO membranes.

    PubMed

    Lee, Hye-Jin; Kim, Hyung-Eun; Lee, Changha

    2017-03-01

    Combinations of Cu(II) with hydroxylamine (HA) and hydrogen peroxide (H 2 O 2 ) (i.e., Cu(II)/HA, Cu(II)/H 2 O 2 , and Cu(II)/HA/H 2 O 2 systems) were investigated for the control of P. aeruginosa biofilms on reverse osmosis (RO) membranes. These Cu(II)-based disinfection systems effectively inactivated P. aeruginosa cells, exhibiting different behaviors depending on the state of bacterial cells (planktonic or biofilm) and the condition of biofilm growth and treatment (normal or pressurized condition). The Cu(II)/HA and Cu(II)/HA/H 2 O 2 systems were the most effective reagents for the inactivation of planktonic cells. However, these systems were not effective in inactivating cells in biofilms on the RO membranes possibly due to the interactions of Cu(I) with extracellular polymeric substances (EPS), where biofilms were grown and treated in center for disease control (CDC) reactors. Different from the results using CDC reactors, in a pressurized cross-flow RO filtration unit, the Cu(II)/HA/H 2 O 2 treatment significantly inactivated biofilm cells formed on the RO membranes, successfully recovering the permeate flux reduced by the biofouling. The pretreatment of feed solutions by Cu(II)/HA and Cu(II)/HA/H 2 O 2 systems (applied before the biofilm formation) effectively mitigated the permeate flux decline by preventing the biofilm growth on the RO membranes. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. Asphalt and risk of cancer in man.

    PubMed Central

    Chiazze, L; Watkins, D K; Amsel, J

    1991-01-01

    Epidemiological publications regarding the carcinogenic potential of asphalt (bitumen) are reviewed. In 1984 the International Agency for Research on Cancer (IARC) stated that there is "inadequate evidence that bitumens alone are carcinogenic to humans." They did, however, conclude that animal data provided sufficient evidence for the carcinogenicity of certain extracts of steam refined and air refined bitumens. In the absence of data on man, IARC considered it reasonable to regard chemicals with sufficient evidence of carcinogenicity in animals as if they presented a carcinogenic risk to man. Epidemiological data for man accumulated since the IARC report do not fulfil the criteria for showing a causal association between exposure to asphalt and development of cancer. The studies cited all suffer from a lack of data on exposure or potential confounders, which are necessary to establish whether or not such an association may or may not exist. In view of the evidence (or lack thereof) regarding asphalt today, an appropriate public health attitude suggests at least that action be taken to protect those working with asphalt by monitoring the workplace, taking whatever steps are possible to minimise exposures and to inform workers of potential hazards. At the same time, a need exists for well designed analytical epidemiological studies to determine whether a risk of cancer in man exists from exposure to asphalt. PMID:1878310

  5. 46 CFR 97.13-1 - Muster lists, emergency signals, and manning.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Muster lists, emergency signals, and manning. 97.13-1... VESSELS OPERATIONS Station Bills § 97.13-1 Muster lists, emergency signals, and manning. The requirements for muster lists, emergency signals, and manning must be in accordance with subchapter W (Lifesaving...

  6. 46 CFR 78.13-1 - Muster lists, emergency signals, and manning.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 3 2013-10-01 2013-10-01 false Muster lists, emergency signals, and manning. 78.13-1... OPERATIONS Station Bills § 78.13-1 Muster lists, emergency signals, and manning. The requirements for muster lists, emergency signals, and manning must be in accordance with subchapter W (Lifesaving Appliances and...

  7. 46 CFR 78.13-1 - Muster lists, emergency signals, and manning.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 3 2014-10-01 2014-10-01 false Muster lists, emergency signals, and manning. 78.13-1... OPERATIONS Station Bills § 78.13-1 Muster lists, emergency signals, and manning. The requirements for muster lists, emergency signals, and manning must be in accordance with subchapter W (Lifesaving Appliances and...

  8. 46 CFR 97.13-1 - Muster lists, emergency signals, and manning.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Muster lists, emergency signals, and manning. 97.13-1... VESSELS OPERATIONS Station Bills § 97.13-1 Muster lists, emergency signals, and manning. The requirements for muster lists, emergency signals, and manning must be in accordance with subchapter W (Lifesaving...

  9. 46 CFR 78.13-1 - Muster lists, emergency signals, and manning.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 3 2012-10-01 2012-10-01 false Muster lists, emergency signals, and manning. 78.13-1... OPERATIONS Station Bills § 78.13-1 Muster lists, emergency signals, and manning. The requirements for muster lists, emergency signals, and manning must be in accordance with subchapter W (Lifesaving Appliances and...

  10. 46 CFR 97.13-1 - Muster lists, emergency signals, and manning.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Muster lists, emergency signals, and manning. 97.13-1... VESSELS OPERATIONS Station Bills § 97.13-1 Muster lists, emergency signals, and manning. The requirements for muster lists, emergency signals, and manning must be in accordance with subchapter W (Lifesaving...

  11. 46 CFR 196.13-1 - Muster lists, emergency signals, and manning.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Muster lists, emergency signals, and manning. 196.13-1... VESSELS OPERATIONS Station Bills § 196.13-1 Muster lists, emergency signals, and manning. The requirements for muster lists, emergency signals, and manning must be in accordance with subchapter W (Lifesaving...

  12. 46 CFR 196.13-1 - Muster lists, emergency signals, and manning.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Muster lists, emergency signals, and manning. 196.13-1... VESSELS OPERATIONS Station Bills § 196.13-1 Muster lists, emergency signals, and manning. The requirements for muster lists, emergency signals, and manning must be in accordance with subchapter W (Lifesaving...

  13. 46 CFR 78.13-1 - Muster lists, emergency signals, and manning.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 3 2011-10-01 2011-10-01 false Muster lists, emergency signals, and manning. 78.13-1... OPERATIONS Station Bills § 78.13-1 Muster lists, emergency signals, and manning. The requirements for muster lists, emergency signals, and manning must be in accordance with subchapter W (Lifesaving Appliances and...

  14. 46 CFR 196.13-1 - Muster lists, emergency signals, and manning.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Muster lists, emergency signals, and manning. 196.13-1... VESSELS OPERATIONS Station Bills § 196.13-1 Muster lists, emergency signals, and manning. The requirements for muster lists, emergency signals, and manning must be in accordance with subchapter W (Lifesaving...

  15. 46 CFR 97.13-1 - Muster lists, emergency signals, and manning.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Muster lists, emergency signals, and manning. 97.13-1... VESSELS OPERATIONS Station Bills § 97.13-1 Muster lists, emergency signals, and manning. The requirements for muster lists, emergency signals, and manning must be in accordance with subchapter W (Lifesaving...

  16. 46 CFR 196.13-1 - Muster lists, emergency signals, and manning.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Muster lists, emergency signals, and manning. 196.13-1... VESSELS OPERATIONS Station Bills § 196.13-1 Muster lists, emergency signals, and manning. The requirements for muster lists, emergency signals, and manning must be in accordance with subchapter W (Lifesaving...

  17. Removal of Pharmaceutical and Personal Care Products (PPCPs) from Municipal Waste Water with Integrated Membrane Systems, MBR-RO/NF

    PubMed Central

    Wang, Yonggang; Wang, Xu; Li, Mingwei; Dong, Jing; Sun, Changhong; Chen, Guanyi

    2018-01-01

    This study focuses on the application of combining membrane bioreactor (MBR) treatment with reverse osmosis (RO) or nanofiltration (NF) membrane treatment for removal of pharmaceuticals and personal care products (PPCPs) in municipal wastewater. Twenty-seven PPCPs were measured in real influent with lowest average concentration being trimethoprim (7.12 ng/L) and the highest being caffeine (18.4 ng/L). The results suggest that the MBR system effectively removes the PPCPs with an efficiency of between 41.08% and 95.41%, and that the integrated membrane systems, MBR-RO/NF, can achieve even higher removal rates of above 95% for most of them. The results also suggest that, due to the differences in removal mechanisms of NF/RO membrane, differences of removal rates exist. In this study, the combination of MBR-NF resulted in the removal of 13 compounds to below detection limits and MBR-RO achieved even better results with removal of 20 compounds to below detection limits. PMID:29401723

  18. Removal of Pharmaceutical and Personal Care Products (PPCPs) from Municipal Waste Water with Integrated Membrane Systems, MBR-RO/NF.

    PubMed

    Wang, Yonggang; Wang, Xu; Li, Mingwei; Dong, Jing; Sun, Changhong; Chen, Guanyi

    2018-02-05

    This study focuses on the application of combining membrane bioreactor (MBR) treatment with reverse osmosis (RO) or nanofiltration (NF) membrane treatment for removal of pharmaceuticals and personal care products (PPCPs) in municipal wastewater. Twenty-seven PPCPs were measured in real influent with lowest average concentration being trimethoprim (7.12 ng/L) and the highest being caffeine (18.4 ng/L). The results suggest that the MBR system effectively removes the PPCPs with an efficiency of between 41.08% and 95.41%, and that the integrated membrane systems, MBR-RO/NF, can achieve even higher removal rates of above 95% for most of them. The results also suggest that, due to the differences in removal mechanisms of NF/RO membrane, differences of removal rates exist. In this study, the combination of MBR-NF resulted in the removal of 13 compounds to below detection limits and MBR-RO achieved even better results with removal of 20 compounds to below detection limits.

  19. Synthesis of [{sup 18}F]Ro41-0960, a potent COMT inhibitor, for use in vivo mapping with PET

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ding, Y.S.; Sugano, Y.; Gatley, S.J.

    1995-05-01

    Catechol-O-methyltransferase (COMPT; EC 2.1.1.6) is one of the two major enzymes which metabolize the catecholamine neurotransmitters. It is distributed throughout the body and brain and is elevated in breast cancer tissue when it plays a role in estrogen metabolism. It is also an important molecular target in the development of drugs to treat Parkinson`s disease (PD). Because COMT regulates the concentration of important neurotransmitter amines such as dopamine, there is speculation that abnormalities in its activity may be associated with neurological, and psychiatric disorders. Ro41-9060(3,4-dihydroxy-5-nitro-2{prime}-fluorobenzophenone) is a potent, fluorine containing COMT inhibitor which has been reported to cross the bloodmore » brain barrier. It is structurally similar to Ro40-7592 which is currently undergoing clinical trials in PD. We report the synthesis of [{sup 18}F]Ro41-0960, for investigation for mapping COMT and for studies of COMT drugs. [{sup 18}F]Ro41-0960 was synthesized by the nucleophilic aromatic substitution reaction with NCA [{sup 18}F] fluoride on a protected precursor (prepared via a five-step synthesis) followed by hydrolysis with HBr (synthesis time of 100 min; radiochemical yield of 5-7% (EOB)). Though Ro41-0960 has been reported to cross the blood brain barrier, PET studies in baboon demonstrated that an almost complete absence of the drug from the brain both at tracer doses and with the addition of unlabeled drug (1.5 mg/kg) at all times through a 90 min experimental interval. The plasma to brain ratios of F-18 average about 40:1. However, high uptake was observed in the kidneys and in other organs which are known to have high COMT. Studies in mice showed that at 30 min after injection of tracer, F-18 in kidneys was largely as [{sup 18}F]Ro-41-0960 and that it could be displaced with unlabeled Ro41-0960. These studies provide the first example of a positron emitter labeled COMT radiotracer.« less

  20. Specific role of LeMAN2 in the control of seed germination exposed by overexpression of the LeMAN3 gene in tomato plants.

    PubMed

    Belotserkovsky, Harel; Berger, Yael; Shahar, Ron; Wolf, Shmuel

    2007-12-01

    Endo-beta-mannanase is one of the key enzymes involved in the hydrolysis of the mannan-rich cell walls of tomato (Solanum lycopersicon) seeds. Two isoforms of endo-beta-mannanase have been characterized in tomato seeds: LeMAN2 is active in the micropylar area prior to germination and LeMAN1 is active after germination in all endosperm cells surrounding the cotyledons. To explore whether general mannanase activity in the endosperm cap is sufficient to promote germination, the gene encoding LeMAN3 was inserted into transgenic tomato plants under the control of a CaMV-35S promoter. Expression of LeMAN3 was evident in the endosperm cap and in the lateral endosperm of the transgenic seeds 10 min after imbibition. An activity test indicated increased activity of endo-beta-mannanase in the transgenic lines relative to the control line in all seed parts, during the first 20 h of imbibition. However, overexpression of LeMAN3 in transgenic seeds inhibited seed germination at both optimal and suboptimal temperatures. Detailed RT-PCR analyses revealed the transcription patterns of the genes encoding the various mannanase isoforms, and indicated a delay in LeMAN2 transcription in the endosperm cap of the transgenic seeds. Interestingly, tissue-print assays indicated similar mannanase activity in the micropylar areas for both transgenic and control seeds. These results indicate that overexpression of active endo-beta-mannanase in the endosperm cap is not sufficient to enable hydrolysis of the cell walls or to promote germination of tomato seeds. Cell-wall hydrolysis in these endosperm cells is under tight control and requires the specific activity of LeMAN2.

  1. Radiation hazard during a manned mission to Mars.

    PubMed

    Jäkel, Oliver

    2004-01-01

    The radiation hazard of interplanetary flights is currently one of the major obstacles to manned missions to Mars. Highly energetic, heavy-charged particles from galactic cosmic radiation can not be sufficiently shielded in space vehicles. The long-term radiation effects to humans of these particles are largely unknown. In addition, unpredictable storms of solar particles may expose the crew to doses that lead to acute radiation effects. A manned flight to Mars currently seems to be a high-risk adventure. This article provides an overview on the radiation sources and risks for a crew on a manned flight to Mars, as currently estimated by scientists of the US National Administration for Space and Aeronautics (NASA) and the Space Studies Board (SSB) of the US National Research Council.

  2. Prognostic value of CD8CD45RO tumor infiltrating lymphocytes in patients with extrahepatic cholangiocarcinoma

    PubMed Central

    Kim, Richard; Coppola, Domenico; Wang, Emilie; Chang, Young Doo; Kim, Yuhree; Anaya, Daniel; Kim, Dae Won

    2018-01-01

    Cholangiocarcinoma is a malignancy arising from the biliary tract epithelial cells with poor prognosis. Tumor infiltrating lymphocytes (TIL)s and programmed cell death receptor ligand 1 (PD-L1) have a prognostic impact in various solid tumors. We aimed to investigate TILs and PD-L1 expression and their clinical relevance in cholangiocarcinoma. Tumor samples from 44 patients with resected and histologically verified extrahepatic cholangiocarcinoma were evaluated for CD8, CD45RO and PD-L1 expression, and their correlations with clinicopathological data and survival data were analyzed. Total 44 extrahepatic cholangiocarcinoma tissues were evaluated. CD8+ tumor infiltrating lymphocytes (TIL)s were observed in 30 (68%) tumors. Among them, 14 had CD8+CD45RO+ TILs. PD-L1 was expressed on cancer cells in 10 (22.7%) tumors in 34 evaluable extrahepatic cholangiocarciniomas. The presence of CD8+ TILs or CD8+CD45RO+ TILs was not associated with clinical staging or tumor differentiation. Extrahepatic cholangiocarcinoma with CD8+CD45RO+ TILs had longer overall survival (OS) on univariate (P = 0.013) and multivariate (P = 0.012) analysis. Neither CD8+TIL nor PD-L1 expression on cancer cells correlated significantly with OS. These results add to the understanding of the clinical features associated with CD8 TILs and PD-L1 expression in extrahepatic cholangiocarcinoma, and they support the potential rationale of using PD-1 blockade immunotherapy in cholangiocarcinoma.

  3. General Thomas Dresser White: Renaissance Man in a Dark Age

    DTIC Science & Technology

    2015-06-01

    Interview with Maj Gen Haywood S. Hansell,” interview by Edgar F. Puryear, Jr., February 25, 1979 , Air Force Historical Research Agency. 66 Puryear...man in space, the Air Force collaborated with NASA to develop the Dyna- Soar , a manned spacecraft launched via a Titan rocket and returned as a...glider. For White, “The Dyna- Soar …is the first vehicle which will combine the advantages of manned aircraft and missiles into a

  4. Man...An Endangered Species?

    ERIC Educational Resources Information Center

    Department of the Interior, Washington, DC.

    The general theme of this 1968 yearbook is that man is a threatened species, facing overpopulation and unbridled technology - both self induced. The presentation is broad, relating to many aspects of conservation and natural resources in the United States in a descriptive, non-technical style. The yearbook is divided into major topics: Land…

  5. Man as a Species.

    ERIC Educational Resources Information Center

    Solem, Alan; And Others

    Written in 1964, the document represents experimental material of the Anthropology Curriculum Study Project. The objectives of the project were to discuss the evolution of man as distinguished from the evolution of other species and as related to culture, and to emphasize human diversity. Three brief essays are presented. The first, "The…

  6. RoCoMAR: robots' controllable mobility aided routing and relay architecture for mobile sensor networks.

    PubMed

    Le, Duc Van; Oh, Hoon; Yoon, Seokhoon

    2013-07-05

    In a practical deployment, mobile sensor network (MSN) suffers from a low performance due to high node mobility, time-varying wireless channel properties, and obstacles between communicating nodes. In order to tackle the problem of low network performance and provide a desired end-to-end data transfer quality, in this paper we propose a novel ad hoc routing and relaying architecture, namely RoCoMAR (Robots' Controllable Mobility Aided Routing) that uses robotic nodes' controllable mobility. RoCoMAR repeatedly performs link reinforcement process with the objective of maximizing the network throughput, in which the link with the lowest quality on the path is identified and replaced with high quality links by placing a robotic node as a relay at an optimal position. The robotic node resigns as a relay if the objective is achieved or no more gain can be obtained with a new relay. Once placed as a relay, the robotic node performs adaptive link maintenance by adjusting its position according to the movements of regular nodes. The simulation results show that RoCoMAR outperforms existing ad hoc routing protocols for MSN in terms of network throughput and end-to-end delay.

  7. RoCoMAR: Robots' Controllable Mobility Aided Routing and Relay Architecture for Mobile Sensor Networks

    PubMed Central

    Van Le, Duc; Oh, Hoon; Yoon, Seokhoon

    2013-01-01

    In a practical deployment, mobile sensor network (MSN) suffers from a low performance due to high node mobility, time-varying wireless channel properties, and obstacles between communicating nodes. In order to tackle the problem of low network performance and provide a desired end-to-end data transfer quality, in this paper we propose a novel ad hoc routing and relaying architecture, namely RoCoMAR (Robots' Controllable Mobility Aided Routing) that uses robotic nodes' controllable mobility. RoCoMAR repeatedly performs link reinforcement process with the objective of maximizing the network throughput, in which the link with the lowest quality on the path is identified and replaced with high quality links by placing a robotic node as a relay at an optimal position. The robotic node resigns as a relay if the objective is achieved or no more gain can be obtained with a new relay. Once placed as a relay, the robotic node performs adaptive link maintenance by adjusting its position according to the movements of regular nodes. The simulation results show that RoCoMAR outperforms existing ad hoc routing protocols for MSN in terms of network throughput and end-to-end delay. PMID:23881134

  8. Man-Computer Communication--What Next?

    ERIC Educational Resources Information Center

    Gaines, B. R.

    1978-01-01

    The response to the question "What next?" is a synthesis--a combination of philosophical, psychological, and linguistic scholarship with electronic and computational technologies, under the pressure of commercial requirements for improved man-computer communication. (Author/VT)

  9. MeltMan: Optimization, Evaluation, and Universal Application of a qPCR System Integrating the TaqMan qPCR and Melting Analysis into a Single Assay

    PubMed Central

    Nagy, Alexander; Černíková, Lenka; Vitásková, Eliška; Křivda, Vlastimil; Dán, Ádám; Dirbáková, Zuzana; Jiřincová, Helena; Procházka, Bohumír; Sedlák, Kamil; Havlíčková, Martina

    2016-01-01

    In the present work, we optimised and evaluated a qPCR system integrating 6-FAM (6-carboxyfluorescein)-labelled TaqMan probes and melting analysis using the SYTO 82 (S82) DNA binding dye in a single reaction. We investigated the influence of the S82 on various TaqMan and melting analysis parameters and defined its optimal concentration. In the next step, the method was evaluated in 36 different TaqMan assays with a total of 729 paired reactions using various DNA and RNA templates, including field specimens. In addition, the melting profiles of interest were correlated with the electrophoretic patterns. We proved that the S82 is fully compatible with the FAM-TaqMan system. Further, the advantages of this approach in routine diagnostic TaqMan qPCR were illustrated with practical examples. These included solving problems with flat or other atypical amplification curves or even false negativity as a result of probe binding failure. Our data clearly show that the integration of the TaqMan qPCR and melting analysis into a single assay provides an additional control option as well as the opportunity to perform more complex analyses, get more data from the reactions, and obtain analysis results with higher confidence. PMID:27031831

  10. Efficacy of an integrated continuing medical education (CME) and quality improvement (QI) program on radiation oncologist (RO) clinical practice

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Leong, Cheng Nang; Shakespeare, Thomas Philip; North Coast Cancer Institute, Coffs Harbour

    2006-12-01

    Purpose: There has been little radiation oncologist (RO)-specific research in continuing medical education (CME) or quality improvement (QI) program efficacy. Our aim was to evaluate a CME/QI program for changes in RO behavior, performance, and adherence to department protocols/studies over the first 12 months of the program. Methods and Materials: The CME/QI program combined chart audit with feedback (C-AWF), simulation review AWF (SR-AWF), reminder checklists, and targeted CME tutorials. Between April 2003 and March 2004, management of 75 patients was evaluated by chart audit with feedback (C-AWF) and 178 patients via simulation review audit (SR-AWF) using a validated instrument. Scoresmore » were presented, and case management was discussed with individualized educational feedback. RO behavior and performance was compared over the first year of the program. Results: Comparing the first and second 6 months, there was a significant improvement in mean behavior (12.7-13.6 of 14, p = 0.0005) and RO performance (7.6-7.9 of 8, p = 0.018) scores. Protocol/study adherence significantly improved from 90.3% to 96.6% (p = 0.005). A total of 50 actions were generated, including the identification of learning needs to direct CME tutorials, the systematic change of suboptimal RO practice, and the alteration of deficient management of 3% of patients audited during the program. Conclusion: An integrated CME/QI program combining C-AWF, SR-AWF, QI reminders, and targeted CME tutorials effectively improved targeted RO behavior and performance over a 12-month period. There was a corresponding increase in departmental protocol and study adherence.« less

  11. Abundance analysis of roAp stars. IV. HD24712

    NASA Astrophysics Data System (ADS)

    Ryabchikova, T. A.; Landstreet, J. D.; Gelbmann, M. J.; Bolgova, G. T.; Tsymbal, V. V.; Weiss, W. W.

    1997-11-01

    We present the first abundance analysis of the rapidly oscillating chemically peculiar star HD24712, and determine a T_eff,=7250K, log {g},=4.3, and xi_t ,=1kms(-1) . Microturbulence seems to be entirely simulated by a magnetic field with a polar field strength of 4.4kG and of dipolar structure, both of which are supported by our polarimetric observations. Rotation of HD24712 and a spotty surface distribution of the elements result in different mean abundances for different (magnetic) phases. Our results do not support the hypothesis of a monotonic correlation between the amplitude of abundance variations and the atomic number Z, and we present arguments in favour of one of the rotation periods (Prot=12\\fd 4610) discussed in the literature. Rare earth elements are the most overabundant elements relative to the sun, and they have the largest abundance amplitude during a rotation cycle; only Mg has a larger amplitude. For HD24712 we find a clear overabundance of Co while most of the other iron peak elements are underabundant. A comparison of the abundance pattern with the other three roAp stars analyzed so far by us concludes the paper. A systematic difference between surface gravities obtained from spectroscopy and from both asteroseismology and evolutionary tracks is found for the roAp stars HD 24712, alpha Cir, and gamma Equ. Based on observations obtained with the Canada-France-Hawaii telescope, operated by the National Research Council of Canada, the Centre Centre National de la Recherche Scientifique de France, and the University of Hawaii, and on observations obtained at CARSO, Las Campanas, Chile

  12. AUTO PARTS MAN, WORKBOOK.

    ERIC Educational Resources Information Center

    DOVER, BUEL H.

    THE INFORMATION IN THIS STUDY GUIDE WAS DEVELOPED FOR USE IN THE RELATED TECHNICAL CLASSROOM INSTRUCTION PHASE OF THE AUTO PARTS MAN APPRENTICE TRAINING PROGRAM. THE MATERIAL WAS PLANNED UNDER THE DIRECTION OF THE STATE EDUCATIONAL ADVISORY COMMITTEE FOR THE AUTOMOTIVE TRADE. THE UNITS ARE (1) SCOPE AND OPPORTUNITY, (2) AREAS OF RESPONSIBILITY,…

  13. Astrobiology Road Mapping (AstRoMap) - A project within FP7 of the European Commission: First results

    NASA Astrophysics Data System (ADS)

    Gomez-Gomez, Felipe; Capria, Maria Teresa; Palomba, Ernesto; Walter, Nicolas; Rettberg, Petra; Muller, Christian; Horneck, Gerda

    AstRoMap (Astrobiology and Planetary Exploration Road Mapping) is a funded project formulated in the 5th Call of the European Commission FP7 framework. The main objectives of the AstRoMap are: 1. Identify the main astrobiology issues to be addressed by Europe in the next decades in relation with space exploration 2. Identify potential mission concepts that would allow addressing these issues 3. Identify the technology developments required to enable these missions 4. Provide a prioritized roadmap integrating science and technology activities as well as ground-based approach 5. Map scientific knowledge related to astrobiology in Europe To reach those objectives, AstRoMap is executed within the following steps: 1. Community consultation. In order to map the European astrobiology landscape and to provide a collaborative networking platform for this community, the AstRoMap project hosts a database of scientists (European and beyond) interested in astrobiology and planetary exploration (see: http://www.astromap.eu/database.html). It reflects the demography and the research and teaching activities of the astrobiology community, as well as their professional profiles and involvement in astrobiology projects. Considering future aspects of astrobiology in Europe, the need for more astrobiology-dedicated funding programmes at the EU level, especially for cross-disciplinary groups, was stressed. This might eventually lead to the creation of a European laboratory of Astrobiology, or even of a European Astrobiology Institute. 2. Workshops organisation. On the basis of the feedbacks from the community consultation, the potential participants and interesting topics are being identified to take part in the following workshops: 1-. Origin of organic compounds, steps to life; 2. Physico-chemical boundary conditions for habitability 3. Biosignatures as facilitating life detection 4. Origin of the Solar system 3. Astrobiology road-mapping. Based on the results and major conclusions

  14. In vitro resistance development for RO-0335, a novel diphenylether nonnucleoside reverse transcriptase inhibitor.

    PubMed

    Javanbakht, H; Ptak, R G; Chow, E; Yan, J M; Russell, J D; Mankowski, M K; Hogan, P A; Hogg, J H; Vora, H; Hang, J Q; Li, Y; Su, G; Paul, A; Cammack, N; Klumpp, K; Heilek, G

    2010-05-01

    Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are important components of current combination therapies for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. However, their low genetic barriers against resistance development, cross-resistance and serious side effects can compromise the benefits of the first generation compounds in this class (efavirenz and nevirapine). To study potential pathways leading to resistance against the novel diphenylether NNRTI, RO-0335, sequential passage experiments at low multiplicity of infection (MOI) were performed to solicit a stepwise selection of resistance mutations. Two pathways to loss of susceptibility to RO-0335 were observed, containing patterns of amino acid changes at either V106I/A plus F227C (with additional contributions from A98G, V108I, E138K, M230L and P236L) or V106I/Y188L (with a potential contribution from L100I, E138K and Y181C). Characterization of the observed mutations by site-directed mutagenesis in the isogenic HXB2D background demonstrated that a minimum of two or more mutations were required for significant loss of susceptibility, with the exception of Y188L, which requires a two-nucleotide change. Patterns containing F227C or quadruple mutations selected by RO-0335 showed a low relative fitness value when compared to wild-type HXB2D.

  15. 46 CFR 78.13-1 - Muster lists, emergency signals, and manning.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 3 2010-10-01 2010-10-01 false Muster lists, emergency signals, and manning. 78.13-1 Section 78.13-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS OPERATIONS Station Bills § 78.13-1 Muster lists, emergency signals, and manning. The requirements for muster lists, emergency signals, and manning must...

  16. Effect of Variable Manning Coefficients on Tsunami Inundation

    NASA Astrophysics Data System (ADS)

    Barberopoulou, A.; Rees, D.

    2017-12-01

    Numerical simulations are commonly used to help estimate tsunami hazard, improve evacuation plans, issue or cancel tsunami warnings, inform forecasting and hazard assessments and have therefore become an integral part of hazard mitigation among the tsunami community. Many numerical codes exist for simulating tsunamis, most of which have undergone extensive benchmarking and testing. Tsunami hazard or risk assessments employ these codes following a deterministic or probabilistic approach. Depending on the scope these studies may or may not consider uncertainty in the numerical simulations, the effects of tides, variable friction or estimate financial losses, none of which are necessarily trivial. Distributed manning coefficients, the roughness coefficients used in hydraulic modeling, are commonly used in simulating both riverine and pluvial flood events however, their use in tsunami hazard assessments is primarily part of limited scope studies and for the most part, not a standard practice. For this work, we investigate variations in manning coefficients and their effects on tsunami inundation extent, pattern and financial loss. To assign manning coefficients we use land use maps that come from the New Zealand Land Cover Database (LCDB) and more recent data from the Ministry of the Environment. More than 40 classes covering different types of land use are combined into major classes such as cropland, grassland and wetland representing common types of land use in New Zealand, each of which is assigned a unique manning coefficient. By utilizing different data sources for variable manning coefficients, we examine the impact of data sources and classification methodology on the accuracy of model outputs.

  17. The manned space station

    NASA Astrophysics Data System (ADS)

    Kovit, B.

    The development and establishment of a manned space station represents the next major U.S. space program after the Space Shuttle. If all goes according to plan, the space station could be in orbit around the earth by 1992. A 'power tower' station configuration has been selected as a 'reference' design. This configuration involves a central truss structure to which various elements are attached. An eight-foot-square truss forms the backbone of a structure about 400 feet long. At its lower end, nearest the earth, are attached pressurized manned modules. These modules include two laboratory modules and two so-called 'habitat/command' modules, which provide living and working space for the projected crew of six persons. Later, the station's pressurized space would be expanded to accommodate up to 18 persons. By comparison, the Soviets will provide habitable space for 12 aboard a 300-ton station which they are expected to place in orbit. According to current plans the six U.S. astronauts will work in two teams of three persons each. A ninety-day tour of duty is considered.

  18. Man-midwifery history: 1730-1930.

    PubMed

    Shelton, D C

    2012-11-01

    This paper seeks to determine whether the man-midwives William Smellie and William Hunter deserve continuing approbation as 'Founding Fathers' of the obstetrics profession. Scrutiny of their careers reveals their involvement in murders for dissection. In addition, the man-midwifery initiative of delivery in lying-in hospitals resulted in around 1 million more deaths in Britain and Ireland between 1730 and 1930, than would have occurred had home-births remained as the norm. While some may still credit Smellie and Hunter with obstetric discoveries, their knowledge was obtained by murder-for-dissection. That indictment, together with the lying-in hospital legacy, far outweighs their discoveries. The paper invites further constructive discussion and debate, but concludes the accolade of Founding Fathers is undeserved. Any continuing endorsement of Smellie and Hunter effectively demeans the high ethical standards and reputation of current obstetric professionals.

  19. Paleogeothermal record of the Emeishan mantle plume: evidences from borehole Ro data in the Sichuan basin, SW China

    NASA Astrophysics Data System (ADS)

    Hu, S.

    2013-12-01

    The Emeishan basalt province located in the southwest of China is widely accepted to be a result of the eruption of a mantle plume at the time of middle-late Permian. If it was a mantle plume, the ambient sedimentary rocks must be heated up during the development of the mantle plume and this thermal effect must be recorded by some geothermometers in the country rocks. The vitrinite reflectance (Ro) data as a maximum paleotemperature recorder from boreholes in Sichuan basin was employed to expose the thermal regime related to the proposed Emeishan mantle plume. The Ro profiles from boreholes which drilled close to the Emeishan basalts shows a ';dog-leg' (break) style at the unconformity between the middle and the upper Permian, and the Ro profiles in the lower subsection (pre-middle Permian) shows a significantly higher slopes (gradients) than those in the upper subsection. In contrast, those Ro profiles from boreholes far away from the center of the basalt province have no break at the uncomformity. Based on the chemical kinetic model of Ro, the paleo-temperature gradients for the upper and the lower subsections in different boreholes, as well as the erosion at the unconformity between the middle and the upper Permian, were reconstructed to reveal the variations of the temperature gradients and erosion thickness with geological time and space. Both the thermal regime and the erosion thickness together with their spatial variation (structure) provide strong geothermal evidence for the existence of the Emeishan mantle plume in the middle-late Permian.

  20. 46 CFR 169.819 - Manning of lifeboats and liferafts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Manning of lifeboats and liferafts. 169.819 Section 169.819 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Operations § 169.819 Manning of lifeboats and liferafts. (a) The provisions of this section shall...

  1. 46 CFR 169.819 - Manning of lifeboats and liferafts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Manning of lifeboats and liferafts. 169.819 Section 169.819 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Operations § 169.819 Manning of lifeboats and liferafts. (a) The provisions of this section shall...

  2. 46 CFR 169.819 - Manning of lifeboats and liferafts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Manning of lifeboats and liferafts. 169.819 Section 169.819 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Operations § 169.819 Manning of lifeboats and liferafts. (a) The provisions of this section shall...

  3. 46 CFR 169.819 - Manning of lifeboats and liferafts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Manning of lifeboats and liferafts. 169.819 Section 169.819 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Operations § 169.819 Manning of lifeboats and liferafts. (a) The provisions of this section shall...

  4. House Subcommittee - Manned Spaceflight - MSC

    NASA Image and Video Library

    1964-02-15

    George Low, Joseph Piland, Philip Hamburger, Congressman Olin Teague from Texas; and, Congressman Joe D. Waggoner from Louisiana at the entrance to Site 1, Clear Lake, prior to briefing for the House Subcommittee on Manned Spaceflight. MSC, Houston, TX

  5. [The wax and wane of the trend of "man benefits man" in the late Ming Dynasty].

    PubMed

    Zhen, Xue-Yan

    2004-01-01

    It was in the period of from Jia Jing to Wan Li Reign that the trend of medication of "man benefits man" appeared with rather great influence in the society. This medication trend experienced a process of rising, zenith, declining, and eventual termination. Among this trend, the refining process of Hong Qian (Red Lead) and Pan Tao Jiu (Mythical Peach Alcohol) was imbued with the ruin of women, arousing debate soon after the trend appeared, with a tit for tat struggle between two medical schools. This research reveals that such medication trend is an adverse current started by fallacious alchemists. Its influence goes beyond the scope of medical field, though its position in the medical province itself is rather low.

  6. "I Am Chelsea Manning": Comparison of Gendered Representation of Private Manning in U.S. and International News Media.

    PubMed

    Hackl, Andrea M; Becker, Amy B; Todd, Maureen E

    2016-01-01

    On August 22, 2013, Bradley Manning released a statement requesting to be referred to as female. In the following days, the news media discussed whether language should shift toward a female representation. Using quantitative content analysis and qualitative contextual analysis, this study analyzed whether U.S. and international newspapers (N = 197) acknowledged Manning's request to be referred to as "Chelsea" in the two weeks after the statement. Results suggest that the mainstream press was hesitant in shifting toward a female representation. A comparison of international and U.S. newspapers suggests that the U.S. press lagged behind international coverage using a female depiction.

  7. Assessing Man’s Impact on Wetlands,

    DTIC Science & Technology

    1980-12-01

    AD-A94 652 ARMY MILITARY PERSONNEL CENTER ALEXANDRIA VA F/S 8/6 ASSESSZNG MAN’S IMPACT ON WE LANDS,(U) UNCLASSIFIED 0 GALLOWAY 1 A uhuhfuhfhumEIliE...EElliE mrhhmhhhhEEohE mmmmmmmmm Assessing Mns Impact on Wetlands By G.E. Galloway rpp fo f A.l - 5 UN RI pulcto N-RI7-3 D 1 i ILI ’!UNt’ Sea Grant...TITLE (and Subtitle) - - 5. TYPE OF REPORT & PERIOD COVERED /Assessing Man’s Impact on Wetlands December 1980 6. PERFORMING ORG. REPORT NUMBER 7- AU HOR

  8. Ocular bacillary angiomatosis in an immunocompromised man.

    PubMed

    Murray, Meltzer A; Zamecki, Katherine J; Paskowski, Joseph; Lelli, Gary J

    2010-01-01

    An immunocompromised man presented with an inflammatory eyelid lesion. Biopsy was performed; histopathology and special staining confirmed a diagnosis of bacillary angiomatosis. The man was treated with oral erythromycin, and the lesion resolved. The etiologic agents of bacillary angiomatosis are Bartonella henselae and Bartonella quintana, Gram-negative coccobacilli. The organisms stain positively with the Warthin-Starry silver stain. Lesions can be cutaneous or visceral and have been commonly described in immunocompromised patients. Histopathologic examination of lesions reveals angiogenesis and cellular proliferation. Bacillary angiomatosis can be treated with oral antibiotics.

  9. Characterisation of the contribution of the GABA-benzodiazepine α1 receptor subtype to [11C]Ro15-4513 PET images

    PubMed Central

    Myers, James FM; Rosso, Lula; Watson, Ben J; Wilson, Sue J; Kalk, Nicola J; Clementi, Nicoletta; Brooks, David J; Nutt, David J; Turkheimer, Federico E; Lingford-Hughes, Anne R

    2012-01-01

    This positron emission tomography (PET) study aimed to further define selectivity of [11C]Ro15-4513 binding to the GABARα5 relative to the GABARα1 benzodiazepine receptor subtype. The impact of zolpidem, a GABARα1-selective agonist, on [11C]Ro15-4513, which shows selectivity for GABARα5, and the nonselective benzodiazepine ligand [11C]flumazenil binding was assessed in humans. Compartmental modelling of the kinetics of [11C]Ro15-4513 time-activity curves was used to describe distribution volume (VT) differences in regions populated by different GABA receptor subtypes. Those with low α5 were best fitted by one-tissue compartment models; and those with high α5 required a more complex model. The heterogeneity between brain regions suggested spectral analysis as a more appropriate method to quantify binding as it does not a priori specify compartments. Spectral analysis revealed that zolpidem caused a significant VT decrease (∼10%) in [11C]flumazenil, but no decrease in [11C]Ro15-4513 binding. Further analysis of [11C]Ro15-4513 kinetics revealed additional frequency components present in regions containing both α1 and α5 subtypes compared with those containing only α1. Zolpidem reduced one component (mean±s.d.: 71%±41%), presumed to reflect α1-subtype binding, but not another (13%±22%), presumed to reflect α5. The proposed method for [11C]Ro15-4513 analysis may allow more accurate selective binding assays and estimation of drug occupancy for other nonselective ligands. PMID:22214903

  10. Radiation protection for manned space activities

    NASA Technical Reports Server (NTRS)

    Jordan, T. M.

    1983-01-01

    The Earth's natural radiation environment poses a hazard to manned space activities directly through biological effects and indirectly through effects on materials and electronics. The following standard practices are indicated that address: (1) environment models for all radiation species including uncertainties and temporal variations; (2) upper bound and nominal quality factors for biological radiation effects that include dose, dose rate, critical organ, and linear energy transfer variations; (3) particle transport and shielding methodology including system and man modeling and uncertainty analysis; (4) mission planning that includes active dosimetry, minimizes exposure during extravehicular activities, subjects every mission to a radiation review, and specifies operational procedures for forecasting, recognizing, and dealing with large solar flaes.

  11. Brain perfusion imaging using a Reconstruction-of-Difference (RoD) approach for cone-beam computed tomography

    NASA Astrophysics Data System (ADS)

    Mow, M.; Zbijewski, W.; Sisniega, A.; Xu, J.; Dang, H.; Stayman, J. W.; Wang, X.; Foos, D. H.; Koliatsos, V.; Aygun, N.; Siewerdsen, J. H.

    2017-03-01

    Purpose: To improve the timely detection and treatment of intracranial hemorrhage or ischemic stroke, recent efforts include the development of cone-beam CT (CBCT) systems for perfusion imaging and new approaches to estimate perfusion parameters despite slow rotation speeds compared to multi-detector CT (MDCT) systems. This work describes development of a brain perfusion CBCT method using a reconstruction of difference (RoD) approach to enable perfusion imaging on a newly developed CBCT head scanner prototype. Methods: A new reconstruction approach using RoD with a penalized-likelihood framework was developed to image the temporal dynamics of vascular enhancement. A digital perfusion simulation was developed to give a realistic representation of brain anatomy, artifacts, noise, scanner characteristics, and hemo-dynamic properties. This simulation includes a digital brain phantom, time-attenuation curves and noise parameters, a novel forward projection method for improved computational efficiency, and perfusion parameter calculation. Results: Our results show the feasibility of estimating perfusion parameters from a set of images reconstructed from slow scans, sparse data sets, and arc length scans as short as 60 degrees. The RoD framework significantly reduces noise and time-varying artifacts from inconsistent projections. Proper regularization and the use of overlapping reconstructed arcs can potentially further decrease bias and increase temporal resolution, respectively. Conclusions: A digital brain perfusion simulation with RoD imaging approach has been developed and supports the feasibility of using a CBCT head scanner for perfusion imaging. Future work will include testing with data acquired using a 3D-printed perfusion phantom currently and translation to preclinical and clinical studies.

  12. Proceedings of the Second Manned Space Flight Meeting

    NASA Technical Reports Server (NTRS)

    1964-01-01

    The papers presented in this report represent the classified portion of the Second Manned Space Flight Meeting which was held in Dallas, TX, on April 22-24, 1963. The meeting was co-sponsored by the American Institute of Aeronautics and Astronautics and the National Aeronautics and Space Administration. The following subjects are discussed in the report: Manned Space Flight Programs, Launch Vehicles, Spacecraft Design, and Guidance and Control.

  13. A modular approach for assessing the effect of radiation environments on man in operational systems. The radiobiological vulnerability of man during task performance

    NASA Technical Reports Server (NTRS)

    Ewing, D. E.

    1972-01-01

    A modular approach for assessing the affects of radiation environments on man in operational systems has been developed. The feasibility of the model has been proved and the practicality has been assessed. It has been applied to one operational system to date and information obtained has been submitted to systems analysts and mission planners for the assessment of man's vulnerability and impact on systems survivability. In addition, the model has been developed so that the radiobiological data can be input to a sophisticated man-machine interface model to properly relate the radiobiological stress with other mission stresses including the effects of a degraded system.

  14. Man and SuperNature. Lecture 12, September 27, 1946

    ERIC Educational Resources Information Center

    Montessori, Maria

    2015-01-01

    "Man and SuperNature" is a lyrical chapter in the 1946 London course following the emergence of Cosmic Education in Kodaikanal, India. Montessori contrasts the adaptation required of animals for their survival to conscious human adaptation. Animals exist and adapt to nature, but man can alter nature and change the environment.…

  15. A modified CoRoT detrend algorithm and the discovery of a new planetary companion

    NASA Astrophysics Data System (ADS)

    Boufleur, Rodrigo C.; Emilio, Marcelo; Janot-Pacheco, Eduardo; Andrade, Laerte; Ferraz-Mello, Sylvio; do Nascimento, José-Dias, Jr.; de La Reza, Ramiro

    2018-01-01

    We present MCDA, a modification of the COnvection ROtation and planetary Transits (CoRoT) detrend algorithm (CDA) suitable to detrend chromatic light curves. By means of robust statistics and better handling of short-term variability, the implementation decreases the systematic light-curve variations and improves the detection of exoplanets when compared with the original algorithm. All CoRoT chromatic light curves (a total of 65 655) were analysed with our algorithm. Dozens of new transit candidates and all previously known CoRoT exoplanets were rediscovered in those light curves using a box-fitting algorithm. For three of the new cases, spectroscopic measurements of the candidates' host stars were retrieved from the ESO Science Archive Facility and used to calculate stellar parameters and, in the best cases, radial velocities. In addition to our improved detrend technique, we announce the discovery of a planet that orbits a 0.79_{-0.09}^{+0.08} R⊙ star with a period of 6.718 37 ± 0.000 01 d and has 0.57_{-0.05}^{+0.06} RJ and 0.15 ± 0.10 MJ. We also present the analysis of two cases in which parameters found suggest the existence of possible planetary companions.

  16. Distribution of man-machine controls in space teleoperation

    NASA Technical Reports Server (NTRS)

    Bejczy, A. K.

    1982-01-01

    The distribution of control between man and machine is dependent on the tasks, available technology, human performance characteristics and control goals. This dependency has very specific projections on systems designed for teleoperation in space. This paper gives a brief outline of the space-related issues and presents the results of advanced teleoperator research and development at the Jet Propulsion Laboratory (JPL). The research and development work includes smart sensors, flexible computer controls and intelligent man-machine interface devices in the area of visual displays and kinesthetic man-machine coupling in remote control of manipulators. Some of the development results have been tested at the Johnson Space Center (JSC) using the simulated full-scale Shuttle Remote Manipulator System (RMS). The research and development work for advanced space teleoperation is far from complete and poses many interdisciplinary challenges.

  17. PAPR reduction and receiver sensitivity improvement in 16QAM-OFDM RoF system using DMT modulation and BTN-PS technique

    NASA Astrophysics Data System (ADS)

    Shao, Yufeng

    2016-03-01

    In this letter, we present the generation, the peak-to average power ratio (PAPR) reduction, the heterodyne detection, the self-mixing reception, and the transmission performance evaluation of 16QAM-OFDM signals in 60 GHz radio over fiber (RoF) system using Discrete multitone (DMT) modulation and Better Than Nyquist pulse shaping (BTN-PS) technique. DMT modulation is introduced in the RoF system, in-phase and quadrature (IQ) will not be required using BTN-PS method, and the computation complexity is much lower than other published techniques for reduced PAPR in the RoF system. In the experiment, 5 Gb/s 16QAM-OFDM downlink signals are transmitted over 42 km SMF-28 and a 0.4 m wireless channel. The experimental results show that the receiver sensitivity is effectively enhanced using this method. Therefore, the introduced BTN-PS technique and its application is a competitive scheme for reducing PAPR, and enhancing the receiver sensitivity in future RoF system.

  18. One-man electrochemical air revitalization system evaluation

    NASA Technical Reports Server (NTRS)

    Schbert, F. H.; Marshall, R. D.; Hallick, T. M.; Woods, R. R.

    1976-01-01

    A program to evaluate the performance of a one man capacity, self contained electrochemical air revitalization system was successfully completed. The technology readiness of this concept was demonstrated by characterizing the performance of this one man system over wide ranges in cabin atmospheric conditions. The electrochemical air revitalization system consists of a water vapor electrolysis module to generate oxygen from water vapor in the cabin air, and an electrochemical depolarized carbon dioxide concentrator module to remove carbon dioxide from the cabin air. A control/monitor instrumentation package that uses the electrochemical depolarized concentrator module power generated to partially offset the water vapor electrolysis module power requirements and various structural fluid routing components are also part of the system. The system was designed to meet the one man metabolic oxygen generation and carbon dioxide removal requirements, thereby controlling cabin partial pressure of oxygen at 22 kN/sq m and cabin pressure of carbon dioxide at 400 N/sq m over a wide range in cabin air relative humidity conditions.

  19. CHARACTERIZATION OF CoRoT TARGET FIELDS WITH BERLIN EXOPLANET SEARCH TELESCOPE. II. IDENTIFICATION OF PERIODIC VARIABLE STARS IN THE LRc2 FIELD

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kabath, P.; Fruth, T.; Rauer, H.

    2009-04-15

    We report on photometric observations of the CoRoT LRc2 field with the new robotic Berlin Exoplanet Search Telescope II (BEST II). The telescope system was installed and commissioned at the Observatorio Cerro Armazones, Chile, in 2007. BEST II is a small aperture telescope with a wide field of view dedicated to the characterization of the stellar variability primarily in CoRoT target fields with high stellar densities. The CoRoT stellar field LRc2 was observed with BEST II up to 20 nights in 2007 July and August. From the acquired data containing about 100,000 stars, 426 new periodic variable stars were identifiedmore » and 90% of them are located within the CoRoT exoplanetary CCD segments and may be of further interest for CoRoT additional science programs.« less

  20. 46 CFR 169.819 - Manning of lifeboats and liferafts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Manning of lifeboats and liferafts. 169.819 Section 169.819 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Operations § 169.819 Manning of lifeboats and liferafts. (a) The provisions of this section shall apply to all vessels equipped with...

  1. The Body and Language That Man Learns to Use

    ERIC Educational Resources Information Center

    Ribiere, Germaine Anne

    1973-01-01

    The human body provides a medium for man's expression of existence in intellectual, emotional, religious, and social fields. The child starts learning about his body after birth and becomes fully aware of it when he reaches maturity. The fully matured body enables man to carry on dialogue with himself, others and the universe. (PS)

  2. Natural Disasters: Acts of God or Acts of Man?

    ERIC Educational Resources Information Center

    Wijkman, Anders; Timberlake, Lloyd

    This eight-chapter publication considers the man-made and natural causes of natural disasters. Following an introduction, Chapter 1 outlines the increase in natural disasters in the past decade and discusses the ratio of disasters from one continent to another. Chapter 2 discusses man-made factors such as deforestation and overused soil in causing…

  3. Cybernation and Man--A Course Development Project. Final Report.

    ERIC Educational Resources Information Center

    Parkman, Ralph

    An inter-disciplinary course entitled "Cybernation and Man," developed by the School of Engineering at San Jose State College, tries to evaluate the many problems posed to man by the expansion of his technology. It is contended in the course that the most effective approach to control of complex social phenomena within a technological…

  4. Synthesis and applications of MANs/poly(MMA-co-BA) nanocomposite latex by miniemulsion polymerization

    PubMed Central

    Chen, Huayao; Zhou, Xinhua; Gunasekaran, Sundaram

    2017-01-01

    We have synthesized core-shell structured 3-methacryloxypropyltrimethoxysilane (MPS) functionalized antimony-doped tin oxide nanoparticles (MANs)–poly(methyl methacrylate-co-butyl acrylate) (PMMA-co-BA, PMB) nanocomposite latex particles via miniemulsion polymerization method. Polymerizable anionic surfactant DNS-86 (allyloxy polyoxyethylene(10) nonyl ammonium sulfate) was first introduced to synthesize core-shell nanocomposite. The morphologies of synthesized MANs and MANs/PMB latex nanocomposite particles were studied with transmission electron microscopy, which revealed particles, on average 70 nm in size, with a core-shell structure. Owing to the uniformity and hydrophobicity of MANs, the MANs-embedded PMB latex nanocomposite can be tailored more precisely than other nanoparticles-embedded nanocomposites. Films incorporating 10 wt% of MANs in the MAN/PMB latex nanocomposite exhibit good transmittance in the visible region, and excellent opacity in the near infrared region. The MANs/PMB nanocomposite film also appears suitable for heat insulation applications. PMID:29291076

  5. Human performance issues arising from manned space station missions

    NASA Technical Reports Server (NTRS)

    Douglas, William K.

    1986-01-01

    Ten former NASA astronauts were interviewed using a set of 51 questions developed to encourage the contacts to discuss any thoughts, opinions, conclusions, or suggestions which might have evolved since they left the astronaut program. Strict confidentiality was maintained. At least one astronaut from each of the NASA manned space flight programs, excluding the Space Transportation System (Shuttle), was interviewed. The report records the answers to the questions asked, spontaneous comments, and the investigator's own personal evaluations of the material obtained. No statistical analysis of the material was attempted. The professional opinions of these ten experienced astronauts will be of value to persons concerned with the design and operation of manned spacecraft and manned space stations.

  6. Solar-like stars as seen by CoRoT

    NASA Astrophysics Data System (ADS)

    Garcia, R. A.; Appourchaux, T.; Baglin, A.; Auvergne, M.; Barban, C.; Baudin, F.; Michel, E.; Mosser, B.; Samadi, R.; Data Analysis Team D. A. T

    2008-12-01

    For more than a year, photometric high-quality data have been achieved from the CoRoT (COnvection ROtation and Planetary Transits; Baglin et al. 2006, Michel et al. 2008) min- isatellite developed by the French space agency (CNES) in collaboration with the Science Program of ESA, Austria, Belgium, Brazil Germany and Spain. The power spectrum of 4 dif- ferent solar-like stars (stars having sub-surface convective zones showing an acoustic (p) mode spectrum) has been obtained with unprecedented quality allowing the precise study of their seismic properties. These solar-like stars are F stars with masses in the range 1.0 to 1.4 M⊙ and are significantly hotter than the Sun.

  7. 'Botanic Man:' Education or Entertainment?

    ERIC Educational Resources Information Center

    Freeman, Richard

    1979-01-01

    The experience of Thames Television in presenting an educational series during prime time is described. "The Botanic Man," a series on ecology, is a rating success. Several difficulties encountered in collaboration efforts and follow-up activities, including courses and workbook publications, are identified. (JMF)

  8. The growth of Scenedesmus quadricauda in RO concentrate and the impacts on refractory organic matter, Escherichia coli, and trace organic compounds

    EPA Science Inventory

    This study achieves a better operational simplicity for the phycoremediation of reverse osmosis (RO) concentrate using Scenedesmus quadricauda microalgae. Under continuous illumination with CO2 supplementation, algal growth in the RO concentrate resulted in a conversion of polyme...

  9. The growth of Scenedesmus quadricauda in RO concentrate and the impacts on refractory organic matter, Escherichia coli, and trace organic compounds.

    PubMed

    Maeng, Sung Kyu; You, Song Hee; Nam, Joo-Youn; Ryu, Hodon; Timmes, Thomas C; Kim, Hyun-Chul

    2018-05-01

    This study achieves a better operational simplicity for the phycoremediation of reverse osmosis (RO) concentrate using Scenedesmus quadricauda microalgae. Under continuous illumination with CO 2 supplementation, algal growth in the RO concentrate resulted in a conversion of polymeric organic matter (a mixture of humic substances and polysaccharides) to biodegradable fractions and their prompt removal along with inorganic nutrients (NO 3 - and PO 4 3- ). The algal-induced degradation of humic-like substances which are typically refractory to microbial decomposition was demonstrated in an indirect manner. In this study, we also investigated the effects of algal treatment on the growth of Escherichia coli and removal of trace organic compounds (TOrCs) from the RO concentrate. Our results indicate that algal treatment of the RO concentrate using aeration with 10% (v/v) CO 2 under continuous illumination is highly feasible as a safe and inexpensive technology to remove non- or slowly-biodegradable organic matter, reduce enteric bacteria, and attenuate TOrCs in wastewater. However, the results should not be generalized, but critically discussed, due to limitations of using the synthetic RO concentrate in evaluating the performance of wastewater remediation with microalgae. Copyright © 2018 Elsevier Ltd. All rights reserved.

  10. Kimberlites of the Man craton, West Africa

    NASA Astrophysics Data System (ADS)

    Skinner, E. M. W.; Apter, D. B.; Morelli, C.; Smithson, N. K.

    2004-09-01

    The Man craton in West Africa is an Archaean craton formerly joined to the Guyana craton (South America) that was rifted apart in the Mesozoic. Kimberlites of the Man craton include three Jurassic-aged clusters in Guinea, two Jurassic-aged clusters in Sierra Leone, and in Liberia two clusters of unknown age and one Neoproterozoic cluster recently dated at ∼800 Ma. All of the kimberlites irrespective of age occur as small pipes and prolific dykes. Some of the Banankoro cluster pipes in Guinea, the Koidu pipes in Sierra Leone and small pipes in the Weasua cluster in Liberia contain hypabyssal-facies kimberlite and remnants of the so-called transitional-facies and diatreme-facies kimberlite. Most of the Man craton kimberlites are mineralogically classified as phlogopite kimberlites, although potassium contents are relatively low. They are chemically similar to mica-poor Group 1A Southern African examples. The Jurassic kimberlites are considered to represent one province of kimberlites that track from older bodies in Guinea (Droujba 153 Ma) to progressively younger kimberlites in Sierra Leone (Koidu, 146 Ma and Tongo, 140 Ma). The scarcity of diatreme-facies kimberlites relative to hypabyssal-facies kimberlites and the presence of the so-called transitional-facies indicate that the pipes have been eroded down to the interface between the root and diatreme zones. From this observation, it is concluded that extensive erosion (1-2 km) has occurred since the Jurassic. In addition to erosion, the presence of abundant early crystallizing phlogopite is considered to have had an effect on the relatively small sizes of the Man craton kimberlites.

  11. [Albert Schweitzer. The man as a symbol].

    PubMed

    Urdaneta-Carruyo, Eliexer

    2007-01-01

    Albert Schweitzer, the great missionary physician from the XXth century, had a versatile personality that integrated multiple talents, leading to the slightly frequent conjunction of the thinker with the man of action, and the humanist with the scientist and the artist. He studied all these disciplines in a brilliant manner: Philosophy, Theology, Music and Medicine; he was also a great scholar of Bach's work, Jesus Christ and the civilization history. In his maturity, this great man renounced to the fame and glory gained as intellectual and musician, to dedicate his life as a physician for the forgotten African natives. His deeply religious spirit allowed him to penetrate into the most recondite of the human soul; in his personality, he expressed in its entire dimension the eternally unsatisfied desire of the solitary man, against the immensity of the universe. His philosophy, based on the respect for life, was realized throughout the practice of the medical profession. His noble character and personality was based on the man as symbol, since it was not so much what he did helping people but what people could do to others due to him. His singular example represented a moral force in the world, superior to millions of men armed for a war. In 1953, he received the Nobel Peace Prize for his philanthropic work in Africa during more that fifty years, and for his deep love to the living beings. He was transformed in a perennial legend as the Lambaréné doctor.

  12. [A novel TaqMan® MGB probe for specifically detecting Streptococcus mutans].

    PubMed

    Zheng, Hui; Lin, Jiu-Xiang; DU, Ning; Chen, Feng

    2013-10-18

    To design a new TaqMan® MGB probe for improving the specificity of Streptococcus mutans's detection. We extracted six DNA samples from different streptococcal strains for PCR reaction. Conventional nested PCR and TaqMan® MGB real-time PCR were applied independently. The first round of nested PCR was carried out with the bacterial universal primers, while a second PCR was conducted by using primers specific for the 16S rRNA gene of Streptococcus mutans. The TaqMan® MGB probe for Streptococcus mutans was designed from sequence analyses, and the primers were the same as nested PCR. Streptococcus mutans DNA with 2.5 mg/L was sequentially diluted at 5-fold intervals to 0.16 μg/L. Standard DNA samples were used to generate standard curves by TaqMan® MGB real-time PCR. In the nested PCR, the primers specific for Streptococcus mutans also detected Streptococcus gordonii with visible band of 282 bp, giving false-positive results. In the TaqMan® MGB real-time PCR reaction, only Streptococcus mutans was detected. The detection limitation of TaqMan® MGB real-time PCR for Streptococcus mutans 16S rRNA gene was 20 μg/L. We designed a new TaqMan® MGB probe, and successfully set up a PCR based method for detecting oral Streptococcus mutans. TaqMan® MGB real-time PCR is a both specific and sensitive bacterial detection method.

  13. Review of serious events in cases of (suspected) child abuse and/or neglect: A RoSE by any other name?

    PubMed

    Raman, Shanti; Maiese, Michelle; Vasquez, Viviana; Gordon, Paola; Jones, Jennifer M

    2017-08-01

    Child abuse and neglect (CAN) cases presenting to health-services may be complex; when things go seriously wrong such as a child death or near miss, cases are reviewed and health-services and professionals subject to intense scrutiny. While there are a variety of mechanisms to review critical incidents in health-services no formal process for the review of cases where child protection is the primary concern exists in Australia. We aimed to develop a systematic process to review serious events in cases of suspected CAN across two health districts in Sydney, so that shared learnings could fuel system change. Drawing upon mapping, case review, literature findings and using quality improvement methodology, we developed a model named Review of Serious Events (RoSE), in suspected cases of CAN. The RoSE model has the key features of: being child focused; seeking to examine care over a period of time; using child protection staff as lead reviewers; involving health professionals/services in the review who have been involved with the child; and actioning systems change at local levels. The RoSE model was trialled through 2014-2015. Eight cases were reviewed using RoSE; cases were similar to those reviewed prior to having a model. Participant feedback from RoSE group processes was overwhelmingly positive; outputs were transparent and accessible to key stakeholders, there was mixed progress with implementation. The RoSE model is a serious case review process that is strongly child-focused, is both investigative and reflective, led by child protection experts; and can be adapted to other settings and systems. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

  14. 77 FR 21555 - Manning, Richard W.; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-10

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ID-6835-001] Manning, Richard W.; Notice of Filing Take notice that on April 2, 2012, Richard W. Manning submitted for filing, an application for authority to hold interlocking positions, pursuant to section 305(b) of the Federal Power Act, 16 U.S.C. 825d(b) (2008) and section...

  15. Man's nature: innate determinants of response to natural environments

    Treesearch

    B. L. Driver; Peter Greene

    1977-01-01

    Man's sensory mechanisms evolved by natural selection in natural settings and humans survived as a species not so much by the "club in the hand" but by the "plan in the head." That plan or ability enabled man to remember, interpret, and predict environmental events. Humans have an innate capacity (but not necessarily a developed ability) to...

  16. [Man's place and anthropology in bioethics].

    PubMed

    Tomar Romero, Francisca

    2013-01-01

    From the analysis of its epistemological status, the article focuses on the philosophical fundament of bioethics, stressing the need for an authentic anthropology as a reference or starting point. Being an applied ethics, the first fundament of bioethics is in ethics. It shows how only personalistic ethics, which takes as reference the nature or essence of man, can offer objective and universal criteria. Philosophical anthropology studies man as a whole, in an integral manner, from the perspective of its nature or fundamental aspects of his being. It analyzes the distinction and relationship between the philosophical anthropology and the positive anthropologies, as well as with the physical, human and social sciences. Finally, it reflects on the current anthropological crisis and its ethical consequences.

  17. One man electrochemical air revitalization system

    NASA Technical Reports Server (NTRS)

    Huddleston, J. C.; Aylward, J. R.

    1975-01-01

    An integrated water vapor electrolysis (WVE) hydrogen depolarized CO2 concentrator (HDC) system sized for one man support over a wide range of inlet air conditions was designed, fabricated, and tested. Data obtained during 110 days of testing verified that this system can provide the necessary oxygen, CO2 removal, and partial humidity control to support one man (without exceeding a cabin partial pressure of 3.0 mmHg for CO2 and while maintaining a 20% oxygen level), when operated at a WVE current of 50 amperes and an HDC current of 18 amperes. An evaluation to determine the physical properties of tetramethylammonium bicarbonate (TMAC) and hydroxide was made. This provides the necessary electrolyte information for designing an HDC cell using TMAC.

  18. Terrapin technologies manned Mars mission proposal

    NASA Technical Reports Server (NTRS)

    Amato, Michael; Bryant, Heather; Coleman, Rodney; Compy, Chris; Crouse, Patrick; Crunkleton, Joe; Hurtado, Edgar; Iverson, Eirik; Kamosa, Mike; Kraft, Lauri (Editor)

    1990-01-01

    A Manned Mars Mission (M3) design study is proposed. The purpose of M3 is to transport 10 personnel and a habitat with all required support systems and supplies from low Earth orbit (LEO) to the surface of Mars and, after an eight-man surface expedition of 3 months, to return the personnel safely to LEO. The proposed hardware design is based on systems and components of demonstrated high capability and reliability. The mission design builds on past mission experience, but incorporates innovative design approaches to achieve mission priorities. Those priorities, in decreasing order of importance, are safety, reliability, minimum personnel transfer time, minimum weight, and minimum cost. The design demonstrates the feasibility and flexibility of a Waverider transfer module.

  19. Mars manned transportation vehicle

    NASA Technical Reports Server (NTRS)

    Perez-Davis, Marla E.; Faymon, Karl A.

    1987-01-01

    A viable power system technology for a surface transportation vehicle to explore the planet Mars is presented. A number of power traction systems were investigated, and it was found that a regenerative hydrogen-oxygen fuel cell appears to be attractive for a manned Mars rover application. Mission requirements were obtained from the Manned Mars Mission Working Group. Power systems weights, power, and reactants requirements were determined as a function of vehicle weights for vehicles weighing from 6,000 to 16,000 lb (2,722 to 7,257 kg), (Earth weight). The vehicle performance requirements were: velocity, 10 km/hr; range, 100 km; slope climbing capability, 30 deg uphill for 50 km; mission duration, 5 days; and crew, 5. Power requirements for the operation of scientific equipment and support system capabilities were also specified and included in this study. The concept developed here would also be applicable to a Lunar based vehicle for Lunar exploration. The reduced gravity on the Lunar surface, (over that on the Martian surface), would result in an increased range or capability over that of the Mars vehicle since many of the power and energy requirements for the vehicle are gravity dependent.

  20. 46 CFR 185.520 - Abandon ship and man overboard drills and training.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Abandon ship and man overboard drills and training. 185... VESSELS (UNDER 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.520 Abandon ship and man... the water as if during an actual man overboard situation: (1) Once each month, if reasonable and...

  1. 46 CFR 185.520 - Abandon ship and man overboard drills and training.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Abandon ship and man overboard drills and training. 185... VESSELS (UNDER 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.520 Abandon ship and man... the water as if during an actual man overboard situation: (1) Once each month, if reasonable and...

  2. 46 CFR 185.520 - Abandon ship and man overboard drills and training.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Abandon ship and man overboard drills and training. 185... VESSELS (UNDER 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.520 Abandon ship and man... the water as if during an actual man overboard situation: (1) Once each month, if reasonable and...

  3. 46 CFR 185.520 - Abandon ship and man overboard drills and training.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Abandon ship and man overboard drills and training. 185... VESSELS (UNDER 100 GROSS TONS) OPERATIONS Preparations for Emergencies § 185.520 Abandon ship and man... the water as if during an actual man overboard situation: (1) Once each month, if reasonable and...

  4. CD45RA and CD45RO isoforms in infected malnourished and infected well-nourished children

    PubMed Central

    Nájera, O; González, C; Toledo, G; López, L; Cortés, E; Betancourt, M; Ortiz, R

    2001-01-01

    The aim of this study was to determine if the distribution in vivo of CD4+CD45RA+/CD45RO− (naive), CD4+CD45RA+/CD45RO+ (Ddull) and CD4+CD45RO+ (memory) lymphocytes differs in malnourished infected and well-nourished infected children. The expression of CD45RA (naive) and CD45RO (memory) antigens on CD4+ lymphocytes was analysed by flow cytometry in a prospectively followed cohort of 15 malnourished infected, 12 well-nourished infected and 10 well-nourished uninfected children. Malnourished infected children showed higher fractions of Ddull cells (11·4 ± 0·7%) and lower fractions of memory cells (20·3 ± 1·7%) than the well-nourished infected group (8·8 ± 0·8 and 28·1 ± 1·8%, respectively). Well-nourished infected children showed increased percentages of memory cells, an expected response to infection. Impairment of the transition switch to the CD45 isoforms in malnourished children may explain these findings, and may be one of the mechanisms involved in immunodeficiency in these children. PMID:11737063

  5. Thoughts on the cultural evolution of man. Developmental imprinting and transgenerational effect.

    PubMed

    Csaba, György

    2007-01-01

    The biological evolution of man stopped since it has been conveyed to the objects, created by man. This paper introduces the concept of "conveyed evolution". Being part of the cultural evolution, the conveyed evolution is a continuation of the biological one. There are several similarities between the laws of biological and conveyed evolution, albeit the differences are important as well. Some laws of the conveyed evolution are described here. The conveyed evolution has man-made repair mechanisms (medicine, protection of environment) which defend man from harm. Man's fragility limits the progress of conveyed evolution. However, artificial compounds or environmental pollutants which are provoked by the conveyed evolution induce chemical (hormonal) imprinting in the developmental critical periods, which is transmitted to the progeny generations (transgenerational effect). This could cause evolutionary alterations without mutation.

  6. The mapping of the human 52-kD Ro/SSA autoantigen gene to human chromosome II, and its polymorphisms

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Frank, M.B.; Itoh, Kazuko; Fujisaku, Atsushi

    1993-01-01

    Autoantibodies to the ribonucleoprotein Ro/SSA occur in nearly half of the patients with systemic lupus erythematosus and are associated with lymphopenia, photosensitive dermatitis, and pulmonary and renal disease, which suggests that they have an immunopathologic role. The majority of Ro/SSA precipitin-positive patients produce serum antibodies that bind to the 60-kD and 52-kD Ro/SSA proteins. The authors previously isolated and determined the nucleotide sequence of a cDNA clone that encodes the 52-kD form of the human Ro/SSA protein. In the present study, they have determined the chromosomal location of the gene by in situ hybridization to the end of the shortmore » arm of chromosome 11. Hybridization of portions of the cDNA probe to restriction enzyme-digested DNA indicated the gene is composed of at least three exons. The exon encoding the putative zinc fingers of this protein was found to be distinct from that which encodes the leucine zipper. An RFLP of this gene was identified and is associated with the presence of lupus, primarily in black Americans. 60 refs., 3 figs., 3 tabs.« less

  7. 46 CFR 122.520 - Abandon ship and man overboard drills and training.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Abandon ship and man overboard drills and training. 122... OPERATIONS Preparations for Emergencies § 122.520 Abandon ship and man overboard drills and training. (a) The... launched with its assigned crew aboard and maneuvered in the water as if during the actual man overboard...

  8. 46 CFR 122.520 - Abandon ship and man overboard drills and training.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Abandon ship and man overboard drills and training. 122... OPERATIONS Preparations for Emergencies § 122.520 Abandon ship and man overboard drills and training. (a) The... launched with its assigned crew aboard and maneuvered in the water as if during the actual man overboard...

  9. 46 CFR 122.520 - Abandon ship and man overboard drills and training.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Abandon ship and man overboard drills and training. 122... OPERATIONS Preparations for Emergencies § 122.520 Abandon ship and man overboard drills and training. (a) The... launched with its assigned crew aboard and maneuvered in the water as if during the actual man overboard...

  10. 46 CFR 122.520 - Abandon ship and man overboard drills and training.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Abandon ship and man overboard drills and training. 122... OPERATIONS Preparations for Emergencies § 122.520 Abandon ship and man overboard drills and training. (a) The... launched with its assigned crew aboard and maneuvered in the water as if during the actual man overboard...

  11. A 0.8-2.4 μm Transmission spectrum of the hot Jupiter CoRoT-1b

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schlawin, E.; Herter, T.; Zhao, M.

    Hot Jupiters with brightness temperatures ≳2000 K can have TiO and VO molecules as gaseous species in their atmospheres. The TiO and VO molecules can potentially induce temperature inversions in hot Jupiter atmospheres and also have an observable signature of large optical to infrared transit depth ratios. Previous transmission spectra of very hot Jupiters have shown a lack of TiO and VO, but only in planets that also appear to lack temperature inversions. We measure the transmission spectrum of CoRoT-1b, a hot Jupiter that was predicted to have a temperature inversion potentially due to significant TiO and VO in itsmore » atmosphere. We employ the multi-object spectroscopy method using the SpeX and MORIS instruments on the Infrared Telescope Facility (IRTF) and the Gaussian process method to model red noise. By using a simultaneous reference star on the slit for calibration and a wide slit to minimize slit losses, we achieve transit depth precision of 0.03%-0.09%, comparable to the atmospheric scale height but detect no statistically significant molecular features. We combine our IRTF data with optical CoRoT transmission measurements to search for differences in the optical and near-infrared absorption that would arise from TiO/VO. Our IRTF spectrum and the CoRoT photometry disfavor a TiO/VO-rich spectrum for CoRoT-1b, suggesting that the atmosphere has another absorber that could create a temperature inversion or that the blackbody-like emission from the planet is due to a spectroscopically flat cloud, dust, or haze layer that smoothes out molecular features in both CoRoT-1b's emission and transmission spectra. This system represents the faintest planet hosting star (K = 12.2) with a measured planetary transmission spectrum.« less

  12. Water reuse: >90% water yield in MBR/RO through concentrate recycling and CO2 addition as scaling control.

    PubMed

    Joss, Adriano; Baenninger, Claudia; Foa, Paolo; Koepke, Stephan; Krauss, Martin; McArdell, Christa S; Rottermann, Karin; Wei, Yuansong; Zapata, Ana; Siegrist, Hansruedi

    2011-11-15

    Over 1.5 years continuous piloting of a municipal wastewater plant upgraded with a double membrane system (ca. 0.6 m(3) d(-1) of product water produced) have demonstrated the feasibility of achieving high water quality with a water yield of 90% by combining a membrane bioreactor (MBR) with a submerged ultrafiltration membrane followed by a reverse osmosis membrane (RO). The novelty of the proposed treatment scheme consists of the appropriate conditioning of MBR effluent prior to the RO and in recycling the RO concentrates back to the biological unit. All the 15 pharmaceuticals measured in the influent municipal sewage were retained below 100 ng L(-1), a proposed quality parameter, and mostly below detection limits of 10 ng L(-1). The mass balance of the micropollutants shows that these are either degraded or discharged with the excess concentrate, while only minor quantities were found in the excess sludge. The micropollutant load in the concentrate can be significantly reduced by ozonation. A low treated water salinity (<10 mM inorganic salts; 280 ± 70 μS cm(-1)) also confirms that the resulting product has a high water quality. Solids precipitation and inorganic scaling are effectively mitigated by lowering the pH in the RO feed water with CO(2) conditioning, while the concentrate from the RO is recycled to the biological unit where CO(2) is stripped by aeration. This causes precipitation to occur in the bioreactor bulk, where it is much less of a process issue. SiO(2) is the sole exception. Equilibrium modeling of precipitation reactions confirms the effectiveness of this scaling-mitigation approach for CaCO(3) precipitation, calcium phosphate and sulfate minerals. Copyright © 2011 Elsevier Ltd. All rights reserved.

  13. 42 CFR 84.100 - Man tests 1, 2, 3, and 4; requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Man tests 1, 2, 3, and 4; requirements. 84.100 Section 84.100 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL...-Contained Breathing Apparatus § 84.100 Man tests 1, 2, 3, and 4; requirements. Man tests 1, 2, 3, and 4, set...

  14. 42 CFR 84.100 - Man tests 1, 2, 3, and 4; requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Man tests 1, 2, 3, and 4; requirements. 84.100 Section 84.100 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL...-Contained Breathing Apparatus § 84.100 Man tests 1, 2, 3, and 4; requirements. Man tests 1, 2, 3, and 4, set...

  15. 42 CFR 84.100 - Man tests 1, 2, 3, and 4; requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Man tests 1, 2, 3, and 4; requirements. 84.100 Section 84.100 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL...-Contained Breathing Apparatus § 84.100 Man tests 1, 2, 3, and 4; requirements. Man tests 1, 2, 3, and 4, set...

  16. Inhibitory Effects of Cytosolic Ca(2+) Concentration by Ginsenoside Ro Are Dependent on Phosphorylation of IP3RI and Dephosphorylation of ERK in Human Platelets.

    PubMed

    Kwon, Hyuk-Woo; Shin, Jung-Hae; Lee, Dong-Ha; Park, Hwa-Jin

    2015-01-01

    Intracellular Ca(2+) ([Ca(2+)] i ) is platelet aggregation-inducing molecule and is involved in activation of aggregation associated molecules. This study was carried out to understand the Ca(2+)-antagonistic effect of ginsenoside Ro (G-Ro), an oleanane-type saponin in Panax ginseng. G-Ro, without affecting leakage of lactate dehydrogenase, dose-dependently inhibited thrombin-induced platelet aggregation, and the half maximal inhibitory concentration was approximately 155 μM. G-Ro inhibited strongly thrombin-elevated [Ca(2+)] i , which was strongly increased by A-kinase inhibitor Rp-8-Br-cAMPS compared to G-kinase inhibitor Rp-8-Br-cGMPS. G-Ro increased the level of cAMP and subsequently elevated the phosphorylation of inositol 1, 4, 5-triphosphate receptor I (IP3RI) (Ser(1756)) to inhibit [Ca(2+)] i mobilization in thrombin-induced platelet aggregation. Phosphorylation of IP3RI (Ser(1756)) by G-Ro was decreased by PKA inhibitor Rp-8-Br-cAMPS. In addition, G-Ro inhibited thrombin-induced phosphorylation of ERK 2 (42 kDa), indicating inhibition of Ca(2+) influx across plasma membrane. We demonstrate that G-Ro upregulates cAMP-dependent IP3RI (Ser(1756)) phosphorylation and downregulates phosphorylation of ERK 2 (42 kDa) to decrease thrombin-elevated [Ca(2+)] i , which contributes to inhibition of ATP and serotonin release, and p-selectin expression. These results indicate that G-Ro in Panax ginseng is a beneficial novel Ca(2+)-antagonistic compound and may prevent platelet aggregation-mediated thrombotic disease.

  17. Effects of the NOP receptor agonist Ro65-6570 on the acquisition of opiate- and psychostimulant-induced conditioned place preference in rats.

    PubMed

    Rutten, Kris; De Vry, Jean; Bruckmann, Walter; Tzschentke, Thomas M

    2010-10-25

    Activation of the Nociceptin/Orphanin FQ (NOP) receptor may have anti-abuse effects. The present study examined the consequence of NOP receptor activation on the rewarding effect of opiates and psychostimulants in the conditioned place preference task in rats. First, the motivational effect of the NOP receptor agonists Ro64-6198 (0.316-3.16 mg/kg i.p.) and Ro65-6570 (1-10mg/kg i.p.) when administered alone, was assessed. Ro65-6570 was selected for further drug combination studies since, unlike Ro64-6198, it was devoid of an intrinsic motivational effect. Next, the minimal effective dose to induce reward for the opiates heroin (0.1-3.16 mg/kg i.p.), morphine (1-10mg/kg i.p.), hydrocodone (0.316-10mg/kg i.p.), tilidine (1-31.6 mg/kg i.p.), hydromorphone (0.1-10mg/kg i.p.), and oxycodone (0.0316-10mg/kg i.p.), as well as for the psychostimulants cocaine (3.16-31.6 mg/kg i.p.) and dexamphetamine (0.316-3.16 mg/kg i.p.) in combination with Ro 65-6570 (0 or 3.16 mg/kg i.p.) was determined. All drugs produced conditioned place preference, and for opiates and cocaine, but not for dexamphetamine, the minimal effective dose was higher when combined with Ro65-6570 (3.16 mg/kg i.p.). Attenuation of the rewarding effect of tilidine (3.16 mg/kg i.p.) and oxycodone (1mg/kg i.p.) by Ro65-6570 (3.16 mg/kg i.p.) could be reversed by pre-treatment with the NOP receptor antagonist J-113397 (4.64 mg/kg i.p.), suggesting that the attenuating effect of Ro65-6570 on opiates is due to activation of the NOP receptor. Taken together, the present study suggests that activation of NOP receptors effectively attenuates the rewarding effect of opiates, but may be less effective in reducing psychostimulant-induced reward. Copyright © 2010 Elsevier B.V. All rights reserved.

  18. North Korean Civil-Military Trends: Military-First Politics to a Point

    DTIC Science & Technology

    2006-09-01

    to the Great Leader. Yi Yong Mu. The NDC’s impact on the formal leadership lineup was made clear by 2001, when Yi Yong Mu, vice chairman of the NDC...to be restricted, as are career bonds that could come about between officers through sequential appointments to same commands. • First time

  19. RoMo: An efficient strategy for functional mosaic analysis via stochastic Cre recombination and gene targeting in the ROSA26 locus.

    PubMed

    Movahedi, Kiavash; Wiegmann, Robert; De Vlaminck, Karen; Van Ginderachter, Jo A; Nikolaev, Viacheslav O

    2018-07-01

    Functional mosaic analysis allows for the direct comparison of mutant cells with differentially marked control cells in the same organism. While this offers a powerful approach for elucidating the role of specific genes or signalling pathways in cell populations of interest, genetic strategies for generating functional mosaicism remain challenging. We describe a novel and streamlined approach for functional mosaic analysis, which combines stochastic Cre/lox recombination with gene targeting in the ROSA26 locus. With the RoMo strategy a cell population of interest is randomly split into a cyan fluorescent and red fluorescent subset, of which the latter overexpresses a chosen transgene. To integrate this approach into high-throughput gene targeting initiatives, we developed a procedure that utilizes Gateway cloning for the generation of new targeting vectors. RoMo can be used for gain-of-function experiments or for altering signaling pathways in a mosaic fashion. To demonstrate this, we developed RoMo-dnGs mice, in which Cre-recombined red fluorescent cells co-express a dominant-negative Gs protein. RoMo-dnGs mice allowed us to inhibit G protein-coupled receptor activation in a fraction of cells, which could then be directly compared to differentially marked control cells in the same animal. We demonstrate how RoMo-dnGs mice can be used to obtain mosaicism in the brain and in peripheral organs for various cell types. RoMo offers an efficient new approach for functional mosaic analysis that extends the current toolbox and may reveal important new insights into in vivo gene function. © 2018 Wiley Periodicals, Inc.

  20. Water Quality of Hills Water, Supply Water and RO Water Machine at Ulu Yam Selangor

    NASA Astrophysics Data System (ADS)

    Ngadiman, N.; ‘I Bahari, N.; Kaamin, M.; Hamid, N. B.; Mokhtar, M.; Sahat, S.

    2016-07-01

    The rapid development resulted in the deterioration of the quality of drinking water in Malaysia. Recognizing the importance of water quality, new alternatives for drinking water such as mineral water processing from reverse osmosis (RO) machine become more popular. Hence, the demand for mineral water, natural spring water or water from the hills or mountains rose lately. More consumers believed the quality of these spring water better than other source of drinking water. However, the quality of all the drinking water sources is to meet the required quality standard. Therefore, this paper aims to measure the quality of the waters from hills, from RO machine and the water supply in Ulu Yam, Selangor Batang Kali, Malaysia. The water quality was determined based on following parameters: ammoniacal nitrogen (NH3), iron (Fe), turbidity (NTU) and pH. The results show that the water from hills has better quality compared to water supply and water from RO machine. The value of NH3 ranged from 0.03 mg/L- 0.67 mg/L; Fe was from 0.03mg/L - 0.12 mg/L, turbidity at 0.42 NTU - 0.88 NTU and pH is at 6.60 - 0.71. Based on the studied parameters, all three types of water are fit for drinking and have met the required national drinking water quality standard.

  1. Manned Mars mission communication and data management systems

    NASA Technical Reports Server (NTRS)

    White, Ronald E.

    1986-01-01

    A manned Mars mission will involve a small crew and many complex tasks. The productivity of the crew and the entire mission will depend significantly on effective automation of these tasks and the ease with which the crew can interface with them. The technology to support a manned Mars mission is available today; however, evolving software and electronic technology are enabling many interesting possibilities for increasing productivity and safety while reducing life cycle cost. Some of these advanced technologies are identified.

  2. Prosthetic EMG control enhancement through the application of man-machine principles

    NASA Technical Reports Server (NTRS)

    Simcox, W. A.

    1977-01-01

    An area in medicine that appears suitable to man-machine principles is rehabilitation research, particularly when the motor aspects of the body are involved. If one considers the limb, whether functional or not, as the machine, the brain as the controller and the neuromuscular system as the man-machine interface, the human body is reduced to a man-machine system that can benefit from the principles behind such systems. The area of rehabilitation that this paper deals with is that of an arm amputee and his prosthetic device. Reducing this area to its man-machine basics, the problem becomes one of attaining natural multiaxis prosthetic control using Electromyographic activity (EMG) as the means of communication between man and prothesis. In order to use EMG as the communication channel it must be amplified and processed to yield a high information signal suitable for control. The most common processing scheme employed is termed Mean Value Processing. This technique for extracting the useful EMG signal consists of a differential to single ended conversion to the surface activity followed by a rectification and smoothing.

  3. 46 CFR 25.26-20 - Other manned uninspected commercial vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Other manned uninspected commercial vessels. 25.26-20 Section 25.26-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY UNINSPECTED VESSELS REQUIREMENTS Emergency Position Indicating Radio Beacons (EPIRB) § 25.26-20 Other manned uninspected commercial vessels...

  4. 46 CFR 199.100 - Manning of survival craft and supervision.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Manning of survival craft and supervision. 199.100 Section 199.100 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LIFESAVING APPLIANCES....100 Manning of survival craft and supervision. (a) There must be a sufficient number of trained...

  5. 46 CFR 199.100 - Manning of survival craft and supervision.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Manning of survival craft and supervision. 199.100 Section 199.100 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LIFESAVING APPLIANCES....100 Manning of survival craft and supervision. (a) There must be a sufficient number of trained...

  6. 46 CFR 199.100 - Manning of survival craft and supervision.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Manning of survival craft and supervision. 199.100 Section 199.100 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LIFESAVING APPLIANCES....100 Manning of survival craft and supervision. (a) There must be a sufficient number of trained...

  7. 46 CFR 199.100 - Manning of survival craft and supervision.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Manning of survival craft and supervision. 199.100 Section 199.100 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LIFESAVING APPLIANCES....100 Manning of survival craft and supervision. (a) There must be a sufficient number of trained...

  8. Jean Vigo's "Zéro De Conduite" and the Spaces of Revolt

    ERIC Educational Resources Information Center

    Vanobbergen, Bruno; Grosvenor, Ian; Simon, Frank

    2014-01-01

    In this article we will contribute to the contemporary theoretical debate about film by considering, from a history-of-education perspective, the film "Zéro de conduite" by Jean Vigo (1905--1934). This film is classified under the umbrella of "poetic realism": a product of "cinéma de gauche" and an avant-gardist,…

  9. Proprioception in the extraocular muscles of mammals and man.

    PubMed

    Blumer, Roland; Konacki, Kadriye Zeynep; Streicher, Johannes; Hoetzenecker, Wolfram; Blumer, Michael Josef Franz; Lukas, Julius-Robert

    2006-06-01

    This article summarizes the authors' previous studies on proprioceptors in extraocular muscles (EOMs) of mammals and man. They report on muscle spindles in the EOMs of man, Golgi tendon organs in the EOMs of even-toed ungulates, and palisade endings in the EOMs of the cat. Muscle spindles: Muscle spindles are present in the EOMs of some mammals and in the EOMs of man. Compared with muscle spindles in other skeletal muscles, those in human EOMs exhibit structural differences. These structural differences may indicate a special function. Golgi tendon organs: Golgi tendon organs are absent in human EOMs. Golgi tendon organs exhibiting a specific morphology are present in the EOMs of even-toed ungulates. Their high number and rich innervation indicate functional importance. Palisade endings: Palisade endings are nervous end organs confined to the EOMs of mammals and man. It is assumed that these organs have a proprioceptive function. The authors show that palisade endings are immunoreactive for antibodies against choline acetyltransferase. Neuromuscular contacts, if present in palisade endings, are alpha -bungarotoxin positive as well. Taken together, these results show that palisade endings exhibit molecular characteristics of effector organs.

  10. Man-Robot Symbiosis: A Framework For Cooperative Intelligence And Control

    NASA Astrophysics Data System (ADS)

    Parker, Lynne E.; Pin, Francois G.

    1988-10-01

    The man-robot symbiosis concept has the fundamental objective of bridging the gap between fully human-controlled and fully autonomous systems to achieve true man-robot cooperative control and intelligence. Such a system would allow improved speed, accuracy, and efficiency of task execution, while retaining the man in the loop for innovative reasoning and decision-making. The symbiont would have capabilities for supervised and unsupervised learning, allowing an increase of expertise in a wide task domain. This paper describes a robotic system architecture facilitating the symbiotic integration of teleoperative and automated modes of task execution. The architecture reflects a unique blend of many disciplines of artificial intelligence into a working system, including job or mission planning, dynamic task allocation, man-robot communication, automated monitoring, and machine learning. These disciplines are embodied in five major components of the symbiotic framework: the Job Planner, the Dynamic Task Allocator, the Presenter/Interpreter, the Automated Monitor, and the Learning System.

  11. Manning's roughness coefficient for Illinois streams

    USGS Publications Warehouse

    Soong, David T.; Prater, Crystal D.; Halfar, Teresa M.; Wobig, Loren A.

    2012-01-01

    Manning's roughness coefficients for 43 natural and constructed streams in Illinois are reported and displayed on a U.S. Geological Survey Web site. At a majority of the sites, discharge and stage were measured, and corresponding Manning's coefficients—the n-values—were determined at more than one river discharge. The n-values discussed in this report are computed from data representing the stream reach studied and, therefore, are reachwise values. Presentation of the resulting n-values takes a visual-comparison approach similar to the previously published Barnes report (1967), in which photographs of channel conditions, description of the site, and the resulting n-values are organized for each site. The Web site where the data can be accessed and are displayed is at URL http://il.water.usgs.gov/proj/nvalues/.

  12. The Role of the Nuclear Envelope Protein MAN1 in Mesenchymal Stem Cell Differentiation.

    PubMed

    Bermeo, Sandra; Al-Saedi, Ahmed; Kassem, Moustapha; Vidal, Christopher; Duque, Gustavo

    2017-12-01

    Mutations in MAN1, a protein of the nuclear envelope, cause bone phenotypes characterized by hyperostosis. The mechanism of this pro-osteogenic phenotype remains unknown. We increased and decreased MAN1 expression in mesenchymal stem cells (MSC) upon which standard osteogenic and adipogenic differentiation were performed. MAN1 knockdown increased osteogenesis and mineralization. In contrast, osteogenesis remained stable upon MAN1 overexpression. Regarding a mechanism, we found that low levels of MAN1 facilitated the nuclear accumulation of regulatory smads and smads-related complexes, with a concurrently high expression of nuclear β-Catenin. In addition, we found adipogenesis to be decreased in both conditions, although predominantly affected by MAN1 overexpression. Finally, lamin A, a protein of the nuclear envelope that regulates MSC differentiation, was unaffected by changes in MAN1. In conclusion, our studies demonstrated that lower levels of MAN1 in differentiating MSC are associated with higher osteogenesis and lower adipogenesis. High levels of MAN1 only affected adipogenesis. These effects could have an important role in the understanding of the role of the proteins of the nuclear envelope in bone formation. J. Cell. Biochem. 118: 4425-4435, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  13. 42 CFR 84.100 - Man tests 1, 2, 3, and 4; requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Man tests 1, 2, 3, and 4; requirements. 84.100...-Contained Breathing Apparatus § 84.100 Man tests 1, 2, 3, and 4; requirements. Man tests 1, 2, 3, and 4, set forth in Tables 1, 2, 3, and 4 of this subpart, respectively, prescribe the duration and sequence of...

  14. Use of IPsec by Manned Space Missions

    NASA Technical Reports Server (NTRS)

    Pajevski, Michael J.

    2009-01-01

    NASA's Constellation Program is developing its next generation manned space systems for missions to the International Space Station (ISS) and the Moon. The Program is embarking on a path towards standards based Internet Protocol (IP) networking for space systems communication. The IP based communications will be paired with industry standard security mechanisms such as Internet Protocol Security (IPsec) to ensure the integrity of information exchanges and prevent unauthorized release of sensitive information in-transit. IPsec has been tested in simulations on the ground and on at least one Earth orbiting satellite, but the technology is still unproven in manned space mission situations and significant obstacles remain.

  15. The multi-axis vibration environment and man.

    PubMed

    Lovesey, E J

    1970-12-01

    Many investigations into the effects of vibration on man have been performed since Mallock's first study of London Underground vibrations in 1902. The vibration research has tended to be confined to the vertical (heave) axis, yet recent experiments have indicated that low frequency vibration along the lateral (sway) axis has a greater adverse effect upon comfort and performance. Measurements of the vibration environments in current forms of transport including motor vehicles, hovercraft and aircraft etc have shown that appreciable quantities of vibration along all three axes exist. Further vibration research should consider the effects of multi-axis vibrations upon man rather than limit tests to single axis vibration.

  16. Results of the First US Manned Orbital Space Flight

    NASA Technical Reports Server (NTRS)

    1962-01-01

    The results of the first United States manned orbital space flight conducted on February 20, 1962 are presented. The prelaunch activities, spacecraft description, flight operations, flight data, and postflight analyses presented form a continuation of the information previously published for the two United States manned suborbital space flights conducted on May 5, 1961, and July 21, 1961, respectively, by the National Aeronautics and Space Administration.

  17. Raman investigation of ro-vibrational modes of interstitial H2 in Si

    NASA Astrophysics Data System (ADS)

    Koch, S. G.; Lavrov, E. V.; Weber, J.

    2012-08-01

    A Raman scattering study of ro-vibrational transitions Q(J) of the interstitial H2 in Si is presented. It is shown that the Q(2) mode of para hydrogen is coupled to the TAX phonon of Si. The mode appears in the spectra at temperatures above 200 K. The results presented also suggest that the Q(3) transition of ortho hydrogen is resonantly coupled to the OΓ phonon.

  18. New global electron density observations from GPS-RO in the D- and E-Region ionosphere

    NASA Astrophysics Data System (ADS)

    Wu, Dong L.

    2018-06-01

    A novel retrieval technique is developed for electron density (Ne) in the D- and E-region (80-120 km) using the high-quality 50-Hz GPS radio occultation (GPS-RO) phase measurements. The new algorithm assumes a slow, linear variation in the F-region background when the GPS-RO passes through the D- and E-region, and extracts the Ne profiles at 80-130 km from the phase advance signal caused by Ne. Unlike the conventional Abel function, the new approach produces a sharp Ne weighting function in the lower ionosphere, and the Ne retrievals are in good agreement with the IRI (International Reference Ionosphere) model in terms of monthly maps, zonal means and diurnal variations. The daytime GPS-RO Ne profiles can be well characterized by the α-Chapman function of three parameters (NmE, hmE and H), showing that the bottom of E-region is deepening and sharpening towards the summer pole. At high latitudes the monthly GPS-RO Ne maps at 80-120 km reveal clear enhancement in the auroral zones, more prominent at night, as a result of energetic electron precipitation (EEP) from the outer radiation belt. The D-/E-region auroral Ne is strongly correlated with Kp on a daily basis. The new Ne data allow further comprehensive analyses of the sporadic E (Es) phenomena in connection with the background Ne in the E-region. The layered (2-10 km) and fluctuated (<2 km) Es components, namely Ne_Layer than Ne_Pert, are extracted with respect to the background Ne_Region on a profile-by-profile basis. The Ne_Layer component has a strong but highly-refined peak at ∼105 km, with an amplitude smaller than Ne_Region approximately by an order of magnitude. The Ne_Pert component, which was studied extensively in the past, is ∼2 orders of magnitude weaker than Ne_Layer. Both Ne_Layer and Ne_Pert are subject to significant diurnal and semidiurnal variations, showing downward progression with local time in amplitude. The 11-year solar cycle dominates the Ne interannual variations, showing larger Ne

  19. 46 CFR 109.323 - Manning of survival craft and supervision.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Manning of survival craft and supervision. 109.323 Section 109.323 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS OPERATIONS Operation and Stowage of Safety Equipment § 109.323 Manning of survival craft and...

  20. 46 CFR 109.323 - Manning of survival craft and supervision.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Manning of survival craft and supervision. 109.323 Section 109.323 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS OPERATIONS Operation and Stowage of Safety Equipment § 109.323 Manning of survival craft and...

  1. 46 CFR 109.323 - Manning of survival craft and supervision.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Manning of survival craft and supervision. 109.323 Section 109.323 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS OPERATIONS Operation and Stowage of Safety Equipment § 109.323 Manning of survival craft and...

  2. 46 CFR 109.323 - Manning of survival craft and supervision.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Manning of survival craft and supervision. 109.323 Section 109.323 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS OPERATIONS Operation and Stowage of Safety Equipment § 109.323 Manning of survival craft and...

  3. The SARS algorithm: detrending CoRoT light curves with Sysrem using simultaneous external parameters

    NASA Astrophysics Data System (ADS)

    Ofir, Aviv; Alonso, Roi; Bonomo, Aldo Stefano; Carone, Ludmila; Carpano, Stefania; Samuel, Benjamin; Weingrill, Jörg; Aigrain, Suzanne; Auvergne, Michel; Baglin, Annie; Barge, Pierre; Borde, Pascal; Bouchy, Francois; Deeg, Hans J.; Deleuil, Magali; Dvorak, Rudolf; Erikson, Anders; Mello, Sylvio Ferraz; Fridlund, Malcolm; Gillon, Michel; Guillot, Tristan; Hatzes, Artie; Jorda, Laurent; Lammer, Helmut; Leger, Alain; Llebaria, Antoine; Moutou, Claire; Ollivier, Marc; Päetzold, Martin; Queloz, Didier; Rauer, Heike; Rouan, Daniel; Schneider, Jean; Wuchterl, Guenther

    2010-05-01

    Surveys for exoplanetary transits are usually limited not by photon noise but rather by the amount of red noise in their data. In particular, although the CoRoT space-based survey data are being carefully scrutinized, significant new sources of systematic noises are still being discovered. Recently, a magnitude-dependant systematic effect was discovered in the CoRoT data by Mazeh et al. and a phenomenological correction was proposed. Here we tie the observed effect to a particular type of effect, and in the process generalize the popular Sysrem algorithm to include external parameters in a simultaneous solution with the unknown effects. We show that a post-processing scheme based on this algorithm performs well and indeed allows for the detection of new transit-like signals that were not previously detected.

  4. Kant's answer to the question 'what is man?' and its implications for anthropology.

    PubMed

    Cohen, Alix A

    2008-12-01

    This paper examines Kant's anthropological project and its relationship to his conception of 'man' in order to show that Kant's answer to the question 'what is man?' entails a decisive re-evaluation of traditional conceptions of human nature. I argue that Kant redirects the question 'what is man?' away from defining man in terms of what he is, and towards defining him in terms of what he does, in particular through the distinction between three levels of what I will call 'man's praxis': the levels of technicality, prudence, and morality. As soon as man is understood in terms of what he makes of himself rather than in terms of what he is, two crucial issues arise: what is the purpose of his making? And how can he reach this destination? My claim is that whilst the first question is answered by ethics and a doctrine of prudence, the second question is answered by anthropology. In this sense, anthropology plays the crucial role of identifying the worldly helps and hindrances to the realisation of man's purposes--and this is the reason why it should be understood as a 'pragmatic' discipline.

  5. "Reading man flap" design for reconstruction of circular infraorbital and malar skin defects.

    PubMed

    Seyhan, Tamer; Caglar, Baris

    2008-11-01

    Surgical complications such as lid retraction and ectropion from graft or flap scar contracture make reconstruction of skin defects in the malar and infraorbital regions challenging. A new flap design, the reading man flap, was used to overcome these problems. The Limberg and bilobed flap were compared with the reading man flap. The reading man flap consists mainly of a superiorly based quadrangular flap and an inferiorly based triangular flap. Malar and infraorbital circular skin defects measuring 14 x 14 to 40 x 40 mm were reconstructed with a reading man flap in 13 patients. The defects occurred after basal cell carcinoma in all patients. The Limberg flap, bilobed flap, and reading man flap were planned for same-sized defects on the abdominoplasty resection material. The results were compared in terms of total scar area, scar length, and total healthy skin area discarded. When comparing the 3 flap designs, the reading man flap was the most suitable flap in terms of total scar area and length. The reading man flap can be used to reconstruct malar and infraorbital circular defects with good cosmetic results and without creating any tractional forces to the eyelids.

  6. Lowest cost, nearest term options for a manned Mars mission

    NASA Technical Reports Server (NTRS)

    Sauls, Bob; Mortensen, Michael; Myers, Renee; Guacci, Giovanni; Montes, Fred

    1992-01-01

    This study is part of a NASA/USRA Advanced Design Program project executed for the purpose of examining the requirements of a first manned Mars mission. The mission, classified as a split/sprint mission, has been designed for a crew of six with a total manned trip time of one year.

  7. Humanities II: Man and Revolution.

    ERIC Educational Resources Information Center

    Stanton School District, Wilmington, DE.

    "Man and Revolution," the second syllabus in a sequential program, provides 11th grade students with a humanities course that deals heavily in political theory. The rationale, objectives, guidelines, methods, and arrangement are the same as those described in SO 004 030. The introductory unit, followed by further units, helps students define and…

  8. A mutually exclusive stem–loop arrangement in roX2 RNA is essential for X-chromosome regulation in Drosophila

    PubMed Central

    Ilik, Ibrahim Avsar; Maticzka, Daniel; Georgiev, Plamen; Gutierrez, Noel Marie; Backofen, Rolf; Akhtar, Asifa

    2017-01-01

    The X chromosome provides an ideal model system to study the contribution of RNA–protein interactions in epigenetic regulation. In male flies, roX long noncoding RNAs (lncRNAs) harbor several redundant domains to interact with the ubiquitin ligase male-specific lethal 2 (MSL2) and the RNA helicase Maleless (MLE) for X-chromosomal regulation. However, how these interactions provide the mechanics of spreading remains unknown. By using the uvCLAP (UV cross-linking and affinity purification) methodology, which provides unprecedented information about RNA secondary structures in vivo, we identified the minimal functional unit of roX2 RNA. By using wild-type and various MLE mutant derivatives, including a catalytically inactive MLE derivative, MLEGET, we show that the minimal roX RNA contains two mutually exclusive stem–loops that exist in a peculiar structural arrangement: When one stem–loop is unwound by MLE, an alternate structure can form, likely trapping MLE in this perpetually structured region. We show that this functional unit is necessary for dosage compensation, as mutations that disrupt this formation lead to male lethality. Thus, we propose that roX2 lncRNA contains an MLE-dependent affinity switch to enable reversible interactions of the MSL complex to allow dosage compensation of the X chromosome. PMID:29066499

  9. Synergistic Man: Outcome Model for Counselors

    ERIC Educational Resources Information Center

    Rousseve, Ronald J.

    1973-01-01

    Drawing on the insights of Ruth Benedict and Abraham Maslow in their search for an ethical gauge by which to rate personal-social health, this article proposes synergistic man'' as the desired outcome model for counselors. (Author)

  10. The mandibular canal of the "old man" of Cro-Magnon: anatomical-radiological study.

    PubMed

    Goudot, Patrick

    2002-08-01

    The radiological study of the 'old man' of Cro-Magnon mandible complements the one published about the mandibular canal of the "Neanderthal Man" of La Chapelle-aux-Saints with which it is compared. The purpose of this study was to explore the internal structure of this famous fossil. The mandible of the "old man" of Cro-Magnon (22,000 BC) was studied with panoramic radiography and CT scanning. The mandibular canal is similar to that of modern man. The images obtained are of a good quality and can be used for analysis of the internal structures of bony fossils. The mandible of the "old man" of Cro-Magnon belongs to the species Homo sapiens sapiens. Copyright 2002 Published by Elsevier Science Ltd.

  11. 46 CFR 199.100 - Manning of survival craft and supervision.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Manning of survival craft and supervision. 199.100 Section 199.100 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LIFESAVING APPLIANCES AND ARRANGEMENTS LIFESAVING SYSTEMS FOR CERTAIN INSPECTED VESSELS Requirements for All Vessels § 199.100 Manning of survival craft and supervision. (a...

  12. Multiple man-machine interfaces

    NASA Technical Reports Server (NTRS)

    Stanton, L.; Cook, C. W.

    1981-01-01

    The multiple man machine interfaces inherent in military pilot training, their social implications, and the issue of possible negative feedback were explored. Modern technology has produced machines which can see, hear, and touch with greater accuracy and precision than human beings. Consequently, the military pilot is more a systems manager, often doing battle against a target he never sees. It is concluded that unquantifiable human activity requires motivation that is not intrinsic in a machine.

  13. MOOSE: Manned On-Orbit Servicing Equipment

    NASA Technical Reports Server (NTRS)

    Budinoff, J. (Editor); Leontsinis, N. (Editor); Lane, J. (Editor); Singh, R. (Editor); Angelone, K.; Boswell, C.; Chamberlain, I.; Concha, M.; Corrodo, M.; Custodio, O.

    1993-01-01

    The ability to service satellites has thus far been limited to low earth orbit platforms within reach of the Space Shuttle. Other orbits, such as geosynchronous orbits containing high-value spacecraft have not been attainable by a servicing vehicle. The useful life of a satellite can be extended by replacing spent propellant and damaged orbital replacement units, forestalling the need for eventual replacement. This growing need for satellite on-orbits servicing can be met by the Manned On-Orbit Servicing Equipment (MOOSE). Missions requiring orbit transfer capability, precision manipulation and maneuvering, and man-in-the-loop control can be accomplished using MOOSE. MOOSE is a flexible, reusable, single operator, aerobraking spacecraft designed to refuel, repair, and service orbiting spacecraft. MOOSE will be deployed from Space Station Freedom, (SSF), where it will be stored, resupplied, and refurbished.

  14. Man in the Marine Environment.

    ERIC Educational Resources Information Center

    Hogg, Thomas C.; And Others

    The program, Man in the Marine Environment, conducted by the Department of Anthropology, Oregon State University, between July, 1970 and June, 1971, consisted of two major components: (1) research, and (2) direct educational outputs in the form of a series of credit seminars and a public speaker's program. Research, as described in the procedures…

  15. Manned orbital systems concepts study. Book 2: Requirements for extended-duration missions

    NASA Technical Reports Server (NTRS)

    1975-01-01

    In order to provide essential data needed in long-range program planning, the Manned Orbital Systems Concepts (MOSC) study attempted to define, evaluate, and compare concepts for manned orbital systems that provide extended experiment mission capabilities in space, flexibility of operation, and growth potential. Specific areas discussed include roles and requirements for man in future space missions, requirements for extended capability, mission/payload concepts, and preliminary design and operational requirements.

  16. Radiation effects on space-based stellar photometry: theoretical models and empirical results for CoRoT Space Telescope

    NASA Astrophysics Data System (ADS)

    Pinheiro da Silva, L.; Rolland, G.; Lapeyrere, V.; Auvergne, M.

    2008-03-01

    Convection, Rotation and planetary Transits (CoRoT) is a space mission dedicated to stellar seismology and the search for extrasolar planets. Both scientific programs are based on very high precision photometry and require long, uninterrupted observations. The instrument is based on an afocal telescope and a wide-field camera, consisting of four E2V-4280 CCD devices. This set is mounted on a recurrent platform for insertion in low Earth orbit. The CoRoT satellite has been recently launched for a nominal mission duration of three years. In this work, we discuss the impact of space radiation on CoRoT CCDs, in sight of the in-flight characterization results obtained during the satellite's commissioning phase, as well as the very first observational data. We start by describing the population of trapped particles at the satellite altitude, and by presenting a theoretical prediction for the incoming radiation fluxes seen by the CCDs behind shielding. Empirical results regarding particle impact rates and their geographical distribution are then presented and discussed. The effect of particle impacts is also statistically characterized, with respect to the ionizing energy imparted to the CCDs and the size of impact trails. Based on these results, we discuss the effects of space radiation on precise and time-resolved stellar photometry from space. Finally, we present preliminary results concerning permanent radiation damage on CoRoT CCDs, as extrapolated from the data available at the beginning of the satellite's lifetime.

  17. Nomadism as a Man-Environment System

    ERIC Educational Resources Information Center

    Rapoport, Amos

    1978-01-01

    Concepts derived from general man-environment system (MES) models are applied to the specific problem of nomadic sedentarization. The analysis focuses on the manner in which residential mobility may function as a central element in nomadic cultures. (Author/MA)

  18. Man and His Environment: To Perceive and to React: Language Arts. 5111.13.

    ERIC Educational Resources Information Center

    Bermudez, Lynne L.

    A course which is an investigation and appraisal of prose, poetry, fine arts, and music which reflects the environment's effect on man or man's effect on his environment is presented. Performance objectives include the following: (1) Students will formulate a definition of what constitutes man's environment; (2) Students will examine the reactions…

  19. Man-made Boards Technology Trends based on TRIZ Evolution Theory

    NASA Astrophysics Data System (ADS)

    Yu, Huiling; Fan, Delin

    China is one of the world's largest manufacturers and consumers of man-made board applications. A systematic and efficient method of foreseeing future technology trends and their evolutionary potentials is a key task that can help companies guide their planning and allocate their resources. Application of the law of evolution with a S-shaped curve could contribute essentially to the accuracy of the long-term forecast. This research seeks to determine the current stage and the position on the S-curve of man-made board technology in China on the TRIZ evolution theo ryand introduce a methodology which combines patent analysis and technology life cycle forecasting to find a niche space of man-made technology development in China.

  20. Mission analyses for manned flight experiments

    NASA Technical Reports Server (NTRS)

    Orth, J. E.

    1973-01-01

    The investigations to develop a high altitude aircraft program plan are reported along with an analysis of manned comet and asteroid missions, the development of shuttle sortie mission objectives, and an analysis of major management issues facing the shuttle sortie.

  1. MARTI: man-machine animation real-time interface

    NASA Astrophysics Data System (ADS)

    Jones, Christian M.; Dlay, Satnam S.

    1997-05-01

    The research introduces MARTI (man-machine animation real-time interface) for the realization of natural human-machine interfacing. The system uses simple vocal sound-tracks of human speakers to provide lip synchronization of computer graphical facial models. We present novel research in a number of engineering disciplines, which include speech recognition, facial modeling, and computer animation. This interdisciplinary research utilizes the latest, hybrid connectionist/hidden Markov model, speech recognition system to provide very accurate phone recognition and timing for speaker independent continuous speech, and expands on knowledge from the animation industry in the development of accurate facial models and automated animation. The research has many real-world applications which include the provision of a highly accurate and 'natural' man-machine interface to assist user interactions with computer systems and communication with one other using human idiosyncrasies; a complete special effects and animation toolbox providing automatic lip synchronization without the normal constraints of head-sets, joysticks, and skilled animators; compression of video data to well below standard telecommunication channel bandwidth for video communications and multi-media systems; assisting speech training and aids for the handicapped; and facilitating player interaction for 'video gaming' and 'virtual worlds.' MARTI has introduced a new level of realism to man-machine interfacing and special effect animation which has been previously unseen.

  2. Insects Affecting Man. MP-21.

    ERIC Educational Resources Information Center

    Lawson, Fred A.; Spackman, Everett

    The insects discussed in this document are those which have a direct effect upon humans either through a permanent association, as with lice, or a temporary association in the case of flies, bees, wasps, and spiders. In each case, life cycles and identifying characteristics are presented with remarks about the specific effect incurred by man. (CS)

  3. 46 CFR 109.323 - Manning of survival craft and supervision.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Manning of survival craft and supervision. 109.323 Section 109.323 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS OPERATIONS Operation and Stowage of Safety Equipment § 109.323 Manning of survival craft and supervision. (a) There must be a sufficient...

  4. Man-Made Object Extraction from Remote Sensing Imagery by Graph-Based Manifold Ranking

    NASA Astrophysics Data System (ADS)

    He, Y.; Wang, X.; Hu, X. Y.; Liu, S. H.

    2018-04-01

    The automatic extraction of man-made objects from remote sensing imagery is useful in many applications. This paper proposes an algorithm for extracting man-made objects automatically by integrating a graph model with the manifold ranking algorithm. Initially, we estimate a priori value of the man-made objects with the use of symmetric and contrast features. The graph model is established to represent the spatial relationships among pre-segmented superpixels, which are used as the graph nodes. Multiple characteristics, namely colour, texture and main direction, are used to compute the weights of the adjacent nodes. Manifold ranking effectively explores the relationships among all the nodes in the feature space as well as initial query assignment; thus, it is applied to generate a ranking map, which indicates the scores of the man-made objects. The man-made objects are then segmented on the basis of the ranking map. Two typical segmentation algorithms are compared with the proposed algorithm. Experimental results show that the proposed algorithm can extract man-made objects with high recognition rate and low omission rate.

  5. Man's future in space

    NASA Technical Reports Server (NTRS)

    Freitag, R. F.

    1975-01-01

    Studies evaluating potential operational and commercial uses of space are being conducted, taking into account astronomy, astrophysics, manned bases and laboratories in earth orbit, space colonization, terrestrial communications, space processing and manufacturing, interstellar probes, planetary exploration, and the use of space for terrestrial energy supply. The present status in the exploration of the solar system is examined, giving attention to Jupiter, Venus, Mars, and Mercury. A brief outline of the development of human colonies on Mars is presented.

  6. Simultaneous manipulation and observation of multiple ro-vibrational eigenstates in solid para-hydrogen.

    PubMed

    Katsuki, Hiroyuki; Ohmori, Kenji

    2016-09-28

    We have experimentally performed the coherent control of delocalized ro-vibrational wave packets (RVWs) of solid para-hydrogen (p-H 2 ) by the wave packet interferometry (WPI) combined with coherent anti-Stokes Raman scattering (CARS). RVWs of solid p-H 2 are delocalized in the crystal, and the wave function with wave vector k ∼ 0 is selectively excited via the stimulated Raman process. We have excited the RVW twice by a pair of femtosecond laser pulses with delay controlled by a stabilized Michelson interferometer. Using a broad-band laser pulse, multiple ro-vibrational states can be excited simultaneously. We have observed the time-dependent Ramsey fringe spectra as a function of the inter-pulse delay by a spectrally resolved CARS technique using a narrow-band probe pulse, resolving the different intermediate states. Due to the different fringe oscillation periods among those intermediate states, we can manipulate their amplitude ratio by tuning the inter-pulse delay on the sub-femtosecond time scale. The state-selective manipulation and detection of the CARS signal combined with the WPI is a general and efficient protocol for the control of the interference of multiple quantum states in various quantum systems.

  7. Man-caused seismicity of Kuzbass

    NASA Astrophysics Data System (ADS)

    Emanov, Alexandr; Emanov, Alexey; Leskova, Ekaterina; Fateyev, Alexandr

    2010-05-01

    A natural seismicity of Kuznetsk Basin is confined in the main to mountain frame of Kuznetsk hollow. In this paper materials of experimental work with local station networks within sediment basin are presented. Two types of seismicity display within Kuznetsk hollow have been understood: first, man-caused seismic processes, confined to mine working and concentrated on depths up to one and a half of km; secondly, seismic activations on depths of 2-56 km, not coordinated in plan with coal mines. Every of studied seismic activations consists of large quantity of earthquakes of small powers (Ms=1-3). From one to first tens of earthquakes were recorded in a day. The earthquakes near mine working shift in space along with mine working, and seismic process become stronger at the instant a coal-plough machine is operated, and slacken at the instant the preventive works are executed. The seismic processes near three lavas in Kuznetsk Basin have been studied in detail. Uplift is the most typical focal mechanism. Activated zone near mine working reach in diameter 1-1,5 km. Seismic activations not linked with mine working testify that the subsoil of Kuznetsk hollow remain in stress state in whole. The most probable causes of man-caused action on hollow are processes, coupled with change of physical state of rocks at loss of methane from large volume or change by mine working of rock watering in large volume. In this case condensed rocks, lost gas and water, can press out upwards, realizing the reverse fault mechanism of earthquakes. A combination of stress state of hollow with man-caused action at deep mining may account for incipient activations in Kuznetsk Basin. Today earthquakes happen mainly under mine workings, though damages of workings themselves do not happen, but intensive shaking on surface calls for intent study of so dangerous phenomena. In 2009 replicates of the experiment on research of seismic activations in area of before investigated lavas have been conducted

  8. First-in-man study with a novel PEGylated recombinant human insulin-like growth factor-I.

    PubMed

    Kletzl, H; Guenther, A; Höflich, A; Höflich, C; Frystyk, J; Staack, R F; Schick, E; Wandel, C; Bleich, N; Metzger, F

    2017-04-01

    This study is a first time assessment of safety and tolerability, pharmacokinetics, and pharmacodynamics of RO5046013 in human, in comparison with unmodified rhIGF-I. The study was conducted as a single-center, randomized, double-blinded, placebo-controlled, single ascending dose, parallel group study in a clinical research unit in France. A total of 62 healthy volunteers participated in this clinical trial. RO5046013 was given as single subcutaneous injection, or as intravenous infusion over 48h, at ascending dose levels. The active comparator rhIGF-I was administered at 50μg/kg subcutaneously twice daily for 4days. Safety and tolerability, pharmacokinetics, and pharmacodynamics of RO5046013 were evaluated. PEGylation resulted in long exposure to RO5046013 with a half-life of 140-200h. Exposure to RO5046013 increased approximately dose proportionally. RO5046013 was safe and well tolerated at all doses, injection site erythema after SC administration was the most frequent observed AE. No hypoglycemia occurred. Growth hormone (GH) secretion was almost completely suppressed with rhIGF-I administration, whereas RO5046013 caused only a modest decrease in GH at the highest dose given IV. PEGylation of IGF-I strongly enhances half-life, reduces the negative GH feedback and hypoglycemia potential, and therefore offers a valuable alternative to rhIGF-I in treatment of relevant diseases. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Assured crew return vehicle man-systems integration standards

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This is Volume 6 of the Man-Systems Integration Standards (MSIS) family of documents, which is contained in several volumes and a relational database. Each volume has a specific purpose, and each has been assembled from the data contained in the relational database. Volume 6 serves as the Assured Crew Return Vehicle project man-systems integration design requirements. The data in this document is a subset of the data found in Volume 1 and defines the requirements which are pertinent to the Assured Crew Return Vehicle as defined in the SPRD. Additional data and guidelines are provided to assist in the design.

  10. Optimization of Shipboard Manning Levels Using Imprint Pro Forces Module

    DTIC Science & Technology

    2015-09-01

    NPS-OR-15-008 NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA OPTIMIZATION OF SHIPBOARD MANNING LEVELS USING IMPRINT PRO...Optimization of Shipboard Manning Levels Using IMPRINT Pro Forces Module 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER...ABSTRACT The Improved Performance Research Integration Tool ( IMPRINT ) is a dynamic, stochastic, discrete-event modeling tool used to develop a model

  11. Spacecraft Power Systems Engineering: Solutions for NASA's Manned Space Program

    NASA Technical Reports Server (NTRS)

    Scott, John H.

    2007-01-01

    An overview of spacecraft power systems is presented, with a focus on applications in the manned space program. The topics include: 1) History; 2) State-of-the-art; 3) Development directions; 4) Focus on applications in the manned space program led from JSC; 5) Power Systems Engineering Trade Space; 6) Power Generation and Energy Storage; 7) Power Distribution and Control; and 8) Actuation

  12. Predicting U.S. Army Reserve Unit Manning Using Market Demographics

    DTIC Science & Technology

    2015-06-01

    develops linear regression , classification tree, and logistic regression models to determine the ability of the location to support manning requirements... logistic regression model delivers predictive results that allow decision-makers to identify locations with a high probability of meeting unit...manning requirements. The recommendation of this thesis is that the USAR implement the logistic regression model. 14. SUBJECT TERMS U.S

  13. Manned Mars Explorer project: Guidelines for a manned mission to the vicinity of Mars using Phobos as a staging outpost; schematic vehicle designs considering chemical and nuclear electric propulsion

    NASA Technical Reports Server (NTRS)

    Nolan, Sean; Neubek, Deb; Baxmann, C. J.

    1988-01-01

    The Manned Mars Explorer (MME) project responds to the fundamental problems of sending human beings to Mars in a mission scenario and schematic vehicle designs. The mission scenario targets an opposition class Venus inbound swingby for its trajectory with concentration on Phobos and/or Deimos as a staging base for initial and future Mars vicinity operations. Optional vehicles are presented as a comparison using nuclear electric power/propulsion technology. A Manned Planetary Vehicle and Crew Command Vehicle are used to accomplish the targeted mission. The Manned Planetary Vehicle utilizes the mature technology of chemical propulsion combined with an advanced aerobrake, tether and pressurized environment system. The Crew Command Vehicle is the workhorse of the mission performing many different functions including a manned Mars landing, and Phobos rendezvous.

  14. New Radiosonde Temperature Bias Adjustments for Potential NWP Applications Based on GPS RO Data

    NASA Astrophysics Data System (ADS)

    Sun, B.; Reale, A.; Ballish, B.; Seidel, D. J.

    2014-12-01

    Conventional radiosonde observations (RAOBs), along with satellite and other in situ data, are assimilated in numerical weather prediction (NWP) models to generate a forecast. Radiosonde temperature observations, however, have solar and thermal radiation induced biases (typically a warm daytime bias from sunlight heating the sensor and a cold bias at night as the sensor emits longwave radiation). Radiation corrections made at stations based on algorithms provided by radiosonde manufacturers or national meteorological agencies may not be adequate, so biases remain. To adjust these biases, NWP centers may make additional adjustments to radiosonde data. However, the radiation correction (RADCOR) schemes used in the NOAA NCEP data assimilation and forecasting system is outdated and does not cover several widely-used contemporary radiosonde types. This study focuses on work whose objective is to improve these corrections and test their impacts on the NWP forecasting and analysis. GPS Radio Occultation (RO) dry temperature (Tdry) is considered to be highly accurate in the upper troposphere and low stratosphere where atmospheric water vapor is negligible. This study uses GPS RO Tdry from the Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) as the reference to quantify the radiation induced RAOB temperature errors by analyzing ~ 3-yr collocated RAOB and COSMIC GPS RO data compile by the NOAA Products Validation System (NPROVS). The new radiation adjustments are developed for different solar angle categories and for all common sonde types flown in the WMO global operational upper air network. Results for global and several commonly used sondes are presented in the context of NCEP Global Forecast System observation-minus-background analysis, indicating projected impacts in reducing forecast error. Dedicated NWP impact studies to quantify the impact of the new RADCOR schemes on the NCEP analyses and forecast are under consideration.

  15. 13-cis-retinoic acid competitively inhibits 3 alpha-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: a mechanism for its anti-androgenic effects in sebaceous glands?

    PubMed

    Karlsson, Teresa; Vahlquist, Anders; Kedishvili, Natalia; Törmä, Hans

    2003-03-28

    Retinol dehydrogenase-4 (RoDH-4) converts retinol and 13-cis-retinol to corresponding aldehydes in human liver and skin in the presence of NAD(+). RoDH-4 also converts 3 alpha-androstanediol and androsterone into dihydrotestosterone and androstanedione, which may stimulate sebum secretion. This oxidative 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) activity of RoDH-4 is competitively inhibited by retinol and 13-cis-retinol. Here, we further examine the substrate specificity of RoDH-4 and the inhibition of its 3 alpha-HSD activity by retinoids. Recombinant RoDH-4 oxidized 3,4-didehydroretinol-a major form of vitamin A in the skin-to its corresponding aldehyde. 13-cis-retinoic acid (isotretinoin), 3,4-didehydroretinoic acid, and 3,4-didehydroretinol, but not all-trans-retinoic acid or the synthetic retinoids acitretin and adapalene, were potent competitive inhibitors of the oxidative 3 alpha-HSD activity of RoDH-4, i.e., reduced the formation of dihydrotestosterone and androstandione in vitro. Extrapolated to the in vivo situation, this effect might explain the unique sebosuppressive effect of isotretinoin when treating acne.

  16. Numerical Analysis of the Performance of Millimeter-Wave RoF-Based Cellular Backhaul Links

    NASA Astrophysics Data System (ADS)

    Pham, Thu A.; Pham, Hien T. T.; Le, Hai-Chau; Dang, Ngoc T.

    2017-08-01

    In this paper, we study the performance of a next-generation cellular backhaul network that is based on a hybrid architecture using radio-over-fiber (RoF) and millimeter-wave (MMW) techniques. We develop a mathematic model and comprehensively analyze the performance of a MMW/RoF-based backhaul downlink under the impacts of various physical layer impairments originated from both optical fiber and wireless links. More specifically, the effects of nonlinear distortion, chromatic dispersion, fading, and many types of noises including shot noise, thermal noise, amplifier noise, and relative intensity noise are investigated. The numerical results show that the nonlinear distortion, fiber dispersion, and wireless fading are key factors that limit the system performance. Setting the modulation index properly helps minimize the effect of nonlinear distortion while implementing dispersion shifted optical fibers could be used to reduce the impact of dispersion and as a result, they can improve the bit-error rate. Moreover, it is also verified that, to mitigate the effect of multipath fading, remote radio heads should be located as near the remote antenna units as possible.

  17. "On Making Man Modern"--A Review.

    ERIC Educational Resources Information Center

    Rivera, William M.

    A. Inkeles' cross-cultural work is reviewed. Inkeles studied young factory workers in six developing countries (Argentina, Chile, India, Israel, Nigeria, and East Pakistan) to determine their "modernity" characteristics versus their "traditional" or rural orientations. The use of the "modern man" thesis in this study,…

  18. EMMI-Electric solar wind sail facilitated Manned Mars Initiative

    NASA Astrophysics Data System (ADS)

    Janhunen, Pekka; Merikallio, Sini; Paton, Mark

    2015-08-01

    The novel propellantless electric solar wind sail concept promises efficient low thrust transportation in the Solar System outside Earth's magnetosphere. Combined with asteroid mining to provide water and synthetic cryogenic rocket fuel in orbits of Earth and Mars, possibilities for affordable continuous manned presence on Mars open up. Orbital fuel and water enable reusable bidirectional Earth-Mars vehicles for continuous manned presence on Mars and allow smaller fuel fraction of spacecraft than what is achievable by traditional means. Water can also be used as radiation shielding of the manned compartment, thus reducing the launch mass further. In addition, the presence of fuel in the orbit of Mars provides the option for an all-propulsive landing, thus potentially eliminating issues of heavy heat shields and augmenting the capability of pinpoint landing. With this E-sail enabled scheme, the recurrent cost of continuous bidirectional traffic between Earth and Mars might ultimately approach the recurrent cost of running the International Space Station, ISS.

  19. Manned Mars mission accommodation: Sprint mission

    NASA Technical Reports Server (NTRS)

    Cirillo, William M.; Kaszubowski, Martin J.; Ayers, J. Kirk; Llewellyn, Charles P.; Weidman, Deene J.; Meredith, Barry D.

    1988-01-01

    The results of a study conducted at the NASA-LaRC to assess the impacts on the Phase 2 Space Station of Accommodating a Manned Mission to Mars are documented. In addition, several candidate transportation node configurations are presented to accommodate the assembly and verification of the Mars Mission vehicles. This study includes an identification of a life science research program that would need to be completed, on-orbit, prior to mission departure and an assessment of the necessary orbital technology development and demonstration program needed to accomplish the mission. Also included is an analysis of the configuration mass properties and a preliminary analysis of the Space Station control system sizing that would be required to control the station. Results of the study indicate the Phase 2 Space Station can support a manned mission to Mars with the addition of a supporting infrastructure that includes a propellant depot, assembly hangar, and a heavy lift launch vehicle to support the large launch requirements.

  20. Online Mendelian Inheritance in Man (OMIM).

    PubMed

    Hamosh, A; Scott, A F; Amberger, J; Valle, D; McKusick, V A

    2000-01-01

    Online Mendelian Inheritance In Man (OMIM) is a public database of bibliographic information about human genes and genetic disorders. Begun by Dr. Victor McKusick as the authoritative reference Mendelian Inheritance in Man, it is now distributed electronically by the National Center for Biotechnology Information (NCBI). Material in OMIM is derived from the biomedical literature and is written by Dr. McKusick and his colleagues at Johns Hopkins University and elsewhere. Each OMIM entry has a full text summary of a genetic phenotype and/or gene and has copious links to other genetic resources such as DNA and protein sequence, PubMed references, mutation databases, approved gene nomenclature, and more. In addition, NCBI's neighboring feature allows users to identify related articles from PubMed selected on the basis of key words in the OMIM entry. Through its many features, OMIM is increasingly becoming a major gateway for clinicians, students, and basic researchers to the ever-growing literature and resources of human genetics. Copyright 2000 Wiley-Liss, Inc.

  1. Progress-like logistical supply vehicle and the Mars Manned Mission architecture

    NASA Astrophysics Data System (ADS)

    Keith, E. L.

    1993-06-01

    The paper examines the economics of the Russian Progress spacecraft (which has been used to supply Russian space stations with propellant and fresh supplies since 1978), as applied to the American Manned Mars Mission architecture. The results of the examination show that an economic American Progress-like vehicle could be designed significantly different from the Russian spacecraft. The use of a Progress-like vehicle could permit Manned Mars missions without the need for larger heavy-lift vehicles that do not now exist in the American inventory. A MIR-like Manned Mars mission architecture would also enable elimination of most of the extravehicular activity required to assemble a Mars-bound craft.

  2. Conceptual design of a manned orbital transfer vehicle

    NASA Technical Reports Server (NTRS)

    Davis, Richard; Duquette, Miles; Fredrick, Rebecca; Schumacher, Daniel; Somers, Schaeffer; Stafira, Stanley; Williams, James; Zelinka, Mark

    1988-01-01

    With the advent of the manned space station, man now requires a spacecraft based on the space station with the ability to deploy, recover, and repair satellites quickly and economically. Such a craft would prolong and enhance the life and performance of many satellites. A basic design was developed for an orbital tansfer vehicle (OTV). The basic design criteria are discussed. The design of the OTV and systems were researched in the following areas: avionics, crew systems, electrical power systems, environmental control/life support systems, navigation and orbital maneuvers, propulsion systems, reaction control systems (RCS), servicing systems, and structures. The basic concepts in each of the areas are summarized.

  3. Role of the urokinase plasminogen activator receptor in mediating impaired efferocytosis of anti-SSA/Ro-bound apoptotic cardiocytes: Implications in the pathogenesis of congenital heart block.

    PubMed

    Briassouli, Paraskevi; Komissarova, Elena V; Clancy, Robert M; Buyon, Jill P

    2010-08-06

    Binding of maternal anti-Ro/La antibodies to cognate antigen expressed on apoptotic cardiocytes decreases clearance by healthy cardiocytes, which may contribute to the development of autoimmune associated congenital heart block and fatal cardiomyopathy. Given recent evidence implicating the urokinase plasminogen activator receptor (uPAR) as a "don't eat me" signal during efferocytosis, experiments addressed whether surface bound anti-Ro antibodies inhibit apoptotic cell removal via an effect on the expression/function of the urokinase-type plasminogen activator protease uPA/uPAR system. As assessed by flow cytometry and confocal microscopy, uPAR colocalizes and interacts with Ro60 on the surface of apoptotic human fetal cardiocytes. Blocking of uPAR enhances phagocytosis of apoptotic cardiocytes by healthy cardiocytes and reverses the anti-Ro60-dependent impaired clearance of apoptotic cardiocytes. Binding of anti-Ro60 antibodies to apoptotic cardiocytes results in increased uPAR expression, as well as enhanced uPA activity. The binding of anti-Ro60 did not alter other surface molecules involved in cell recognition (calreticulin, CD31, or CD47). These data suggest that increased uPAR expression and uPA activity induced by anti-Ro60 binding to the apoptotic fetal cardiocyte provide a molecular basis by which these antibodies inhibit efferocytosis and ultimately lead to scar of the fetal conduction system and working myocardium.

  4. Muscle 'contractures' and the 'stiff-man' syndrome.

    PubMed

    Slater, J D

    1986-12-01

    The aetiology of the clinical stiff-man syndrome is likely to be heterogenous, but until we have more precise methods of identifying an individual cause the need will continue for this rather flippant appellation in patients whose condition cannot be described in any other way. It is also important because patients may otherwise become labelled as suffering from a psychiatric disorder and may even be falsely accused of abusing diazepam (Westblom, 1978). The reverse is also true, and patients may masquerade as stiff men or women (Price and Allott, 1958; Casati and Rossi, 1969). The endocrine dimension remains and should be tested for carefully, particularly in patients with predominantly lower-limb rigidity whose spasms are a relatively minor aspect of their clinical syndrome. Clearly those patients described by George et al (1984) and Slater (1960) as suffering from the stiff-man syndrome need to be reclassified as examples of the hormonal stiff muscle syndrome, and there may be others so misclassified. An endocrine aetiology may easily be missed in a patient with relatively minor muscle stiffness, pain and cramps, such as the man described by Yunus et al (1981) whose myalgia, 'arthralgia' and muscle tenderness vanished completely within four days of taking physiological replacement doses of cortisone acetate as treatment for his hypopituitarism. The rarity of the stiff-man syndrome makes prospective studies of its aetiology and treatment impossible, yet the dramatic and devastating nature of the syndrome suggests that such cases may be extreme examples of a much more common condition. On the other hand, it is possible to argue that once the psychiatric, the overtly neurological and the endocrine cases are omitted we are left with nothing. However, this is just where Moersch and Woltman came in; they could not explain 14 of their cases. Despite modern technology, despite refinements of diagnosis and despite the increasing recognition of the stiff-man syndrome as a

  5. The Language of Man. Book 4.

    ERIC Educational Resources Information Center

    Littell, Joseph Fletcher, Ed.

    Book 4 of "The Language of Man" series contains articles which deal with semantics, levels of language (including informal, formal and technical language, jargon, and gobbledygook), the hidden persuaders (advertising of merchandise and political candidates), and communications of the future (including the computer and other mass media now being…

  6. Chemistry in "The Ascent of Man."

    ERIC Educational Resources Information Center

    Hostettler, John D.; Brooks, Kenneth

    1980-01-01

    Describes "The Ascent of Man," a course emphasizing science and human values. Detailed are some chemical topics covered in the course, and how these topics are used in other traditional chemistry courses. Topics discussed include alchemy, the chemical revolution, steam engines, the Manhattan project, and several bioethical problems. (CS)

  7. Science-and-Technology-oriented-Society and Man

    NASA Astrophysics Data System (ADS)

    Fukui, Ken'ichi

    This is a special lecture at the 30th anniversary of JICST. To develop science-and-te chnology-oriented society it is important to evaluate and select infinite information resources on science and technology, and to reorganize and apply them. This also relates to humanity. For the future, we have to establish scientific ethics that can exceed the expedience of science and technology. To be concrete, we have to create new industrial value that recovers and reclaims natural resources which men had wasted so far, and we have to establish a new technology to distribute maldistributed industrial benefits equally. And then, the selfcontrol of the human aiming at the harmony of nature and man will secure human liberty, and it will be done by the good function of man's brain.

  8. "A Man's Gotta Do What a Man's Gotta Do!" Masculinity and Manhood in Social Studies Education

    ERIC Educational Resources Information Center

    Hewitt, William L.

    2004-01-01

    Men in the United States are products of society's assumptions about what it means to "be a man." Throughout American history, these assumptions have supported aggression, conflict, and war. Seeing American troops in Iraq conjures comparisons not only to past military ventures but also to the changing face of the masculine warrior. One might see…

  9. Consanguineous marriage in PR China: a study in rural Man (Manchu) communities.

    PubMed

    Wang, W; Qian, Cong; Bittles, A H

    2002-01-01

    Although there is a long history of consanguineous marriage in China, information on its prevalence is very limited. The Man (Qing) dynasty ruled China for over 250 years, but no consanguinity studies have been reported on this important population. The objective of the present investigation was to determine the present-day level of consanguineous marriage in the Man community, and to compare the data with existing consanguinity information on other Chinese populations. The study was conducted in a group of 11 rural Man communities in the north-eastern Chinese province of Liaoning. Household-based interviews were conducted by local staff on 513 couples, 418 of whom were Man with another 95 Man-Han inter-ethnic marriages. Basic pedigrees were constructed to determine the biological relationship between each set of spouses. Thirty of the 418 couples were in a consanguineous union, with a mean coefficient of inbreeding alpha = 0.0012. The small population sizes of the study may have contributed to the spatial variation in the patterns of inbreeding. Across generations there was a reduction in consanguineous marriages and an increase in inter-ethnic unions, which paralleled changes in civil marriage regulations.

  10. The spectrum and some subdivisions of the spectrum of discrete generalized Cesàro operators on [Formula: see text] ([Formula: see text]).

    PubMed

    Yıldırım, Mustafa; Durna, Nuh

    2017-01-01

    The discrete generalized Cesàro matrix [Formula: see text] is the triangular matrix with nonzero entries [Formula: see text], where [Formula: see text]. In this paper, boundedness, compactness, spectra, the fine spectra and subdivisions of the spectra of discrete generalized Cesàro operator on [Formula: see text] ([Formula: see text]) have been determined.

  11. The Scientific-Technological Revolution and the Formation of the New Man

    ERIC Educational Resources Information Center

    Soviet Education, 1976

    1976-01-01

    This issue contains the proceedings of a round table discussion by Ukranian educators, philosophers, and social scientists on the education of the new Soviet man in the era of scientific-technological revolution. The "new man" is defined as the builder of communism, the participant in the transition to an advanced industrial economy.…

  12. A generalization of Cesàro sequence spaces in the Orlicz space

    NASA Astrophysics Data System (ADS)

    Haryadi; Supama; Zulijanto, A.

    2018-04-01

    In this paper, we generalize the Cesàro sequence spaces in the classic Banach space Lp to the generalized Orlicz space Lφ . We construct the space by replacing the norm {\\Vert \\cdot \\Vert }p in Lp with modular ρφ in Lφ . This generalization has lead to the use of the Luxemburg norm to discuss some topological properties of the spaces. We prove results regarding to modular and norm convergence. We also describe some properties of the spaces and a closed subspaces of the space.

  13. T Cell Epitope Mimicry between Sjögren’s Syndrome Antigen A (SSA)/Ro60 and Oral, Gut, Skin and Vaginal Bacteria.

    PubMed Central

    Szymula, Agnieszka; Rosenthal, Jacob; Szczerba, Barbara M; Bagavant, Harini; Fu, Shu Man; Deshmukh, Umesh S.

    2014-01-01

    This study was undertaken to test the hypothesis that Sjogren’s syndrome Antigen A (SSA)/Ro60-reactive T cells are activated by peptides originating from oral and gut bacteria. T cell hybridomas generated from HLA-DR3 transgenic mice recognized 3 regions on Ro60, with core epitopes mapped to amino acids 228-238, 246-256 and 371-381. BLAST analysis identified several mimicry peptides, originating from human oral, intestinal, skin and vaginal bacteria, as well as environmental bacteria. Amongst these, a peptide from the von Willebrand factor type A domain protein (vWFA) from the oral microbe Capnocytphaga ochracea was the most potent activator. Further, Ro60-reactive T cells were activated by recombinant vWFA protein and whole E. coli expressing this protein. These results demonstrate that peptides derived from normal human microbiota can activate Ro60-reactive T cells. Thus, immune responses to commensal microbiota and opportunistic pathogens should be explored as potential triggers for initiating autoimmunity in SLE and Sjögren’s syndrome. PMID:24576620

  14. Manned Space Flight Experiments Symposium: Gemini Missions III and IV

    NASA Technical Reports Server (NTRS)

    1965-01-01

    This is a compilation of papers on in-flight experiments presented at the first symposium of a series, Manned Space Flight Experiments Symposium, sponsored by the National Aeronautics and Space Administration. The results of experiments conducted during the Gemini Missions III and IV are covered. These symposiums are to be conducted for the scientific community at regular intervals on the results of experiments carried out in conjunction with manned space flights.

  15. YSOVAR II: Mapping YSO Inner Disk Structure in NGC 2264 with Simultaneous Spitzer and CoRoT Time Series Photometry

    NASA Astrophysics Data System (ADS)

    Stauffer, John; Morales-Calderon, Maria; Rebull, Luisa; Affer, Laura; Alencar, Sylvia; Allen, Lori; Barrado, David; Bouvier, Jerome; Calvet, Nuria; Carey, Sean; Carpenter, John; Ciardi, David; Covey, Kevin; D'Alessio, Paola; Espaillat, Catherine; Favata, Fabio; Flaccomio, Ettore; Forbrich, Jan; Furesz, Gabor; Hartman, Lee; Herbst, William; Hillenbrand, Lynne; Holtzman, Jon; Hora, Joe; Marchis, Franck; McCaughrean, Mark; Micela, Giusi; Mundt, Reinhard; Plavchan, Peter; Turner, Neal; Skrutzkie, Mike; Smith, Howard; Song, Inseok; Szentgyorgi, Andy; Terebey, Susan; Vrba, Fred; Wasserman, Lawrence; Watson, Alan; Whitney, Barbara; Winston, Elaine; Wood, Kenny

    2011-05-01

    We propose a simultaneous, continuous 30 day observation of the star forming region NGC2264 with Spitzer and CoRoT. NGC2264 is the only nearby, rich star-forming region which can be observed with CoRoT; it is by definition then the only nearby, rich star-forming region where a simultaneous Spitzer/CoRoT campaign is possible. Fortunately, the visibility windows for the two spacecraft overlap, allowing this program to be done in the Nov. 25, 2011 to Jan. 4, 2012 time period. For 10 days, we propose to map the majority of the cluster (a 35'x35' region) to a depth of 48 seconds per point, with each epoch taking 1.7 hours, allowing of order 12 epochs per day. For the other 20 days, we propose to obtaining staring-mode data for two positions in the cluster having a high density of cluster members. We also plan to propose for a variety of other ground and space-based data, most of which would also be simultaneous with the Spitzer and CoRoT observing. These data will allow us to address many astrophysical questions related to the structure and evolution of the disks of young stars and the interaction of those disks with the forming star. The data may also help inform models of planet formation since planets form and migrate through the pre-main sequence disks during the 0.5-5 Myr age range of stars in NGC2264. The data we collect will also provide an archive of the variability properties of young stars that is unmatched in its accuracy, sensitivity, cadence and duration and which therefore could inspire investigation of phenomena which we cannot now imagine. The CoRoT observations have been approved, contingent on approval of a simultaneous Spitzer observing program (this proposal).

  16. Man-Computer Symbiosis Through Interactive Graphics: A Survey and Identification of Critical Research Areas.

    ERIC Educational Resources Information Center

    Knoop, Patricia A.

    The purpose of this report was to determine the research areas that appear most critical to achieving man-computer symbiosis. An operational definition of man-computer symbiosis was developed by: (1) reviewing and summarizing what others have said about it, and (2) attempting to distinguish it from other types of man-computer relationships. From…

  17. Laser Pyro System Standardization and Man Rating

    NASA Technical Reports Server (NTRS)

    Brown, Christopher W.

    2004-01-01

    This viewgraph presentation reviews an X-38 laser pyro system standardization system designed for a new manned rated program. The plans to approve this laser initiation system and preliminary ideas for this system are also provided.

  18. On Being an Angry Black Man

    ERIC Educational Resources Information Center

    Quaye, Stephen John

    2017-01-01

    Black men are often seen as problems, threats, and thugs. The mere existence of a Black body is often met with fear. Using autoethnographic mystory, I blend personal stories, poetry, song lyrics, and analysis to subvert the angry Black man mantra and explore the productive use of anger to stimulate change.

  19. Man-Machine Communication Through a Teletypewriter.

    ERIC Educational Resources Information Center

    Rubinoff, Morris

    A ten-year research study designed a mechanized information system in the information processing field. Special attention was paid to implementation criteria entering into on-line retrieval through man-machine dialog from a remote typewriter or video terminal and four major areas were investigated: search strategies, machine stored indexer aids,…

  20. 46 CFR 196.13-1 - Muster lists, emergency signals, and manning.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Muster lists, emergency signals, and manning. 196.13-1 Section 196.13-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS OPERATIONS Station Bills § 196.13-1 Muster lists, emergency signals, and manning. The requirements for muster lists, emergency signals,...

  1. Pulsations in the late-type Be star HD 50 209 detected by CoRoT

    NASA Astrophysics Data System (ADS)

    Diago, P. D.; Gutiérrez-Soto, J.; Auvergne, M.; Fabregat, J.; Hubert, A.-M.; Floquet, M.; Frémat, Y.; Garrido, R.; Andrade, L.; de Batz, B.; Emilio, M.; Espinosa Lara, F.; Huat, A.-L.; Janot-Pacheco, E.; Leroy, B.; Martayan, C.; Neiner, C.; Semaan, T.; Suso, J.; Catala, C.; Poretti, E.; Rainer, M.; Uytterhoeven, K.; Michel, E.; Samadi, R.

    2009-10-01

    Context: The presence of pulsations in late-type Be stars is still a matter of controversy. It constitutes an important issue to establish the relationship between non-radial pulsations and the mass-loss mechanism in Be stars. Aims: To contribute to this discussion, we analyse the photometric time series of the B8IVe star HD 50 209 observed by the CoRoT mission in the seismology field. Methods: We use standard Fourier techniques and linear and non-linear least squares fitting methods to analyse the CoRoT light curve. In addition, we applied detailed modelling of high-resolution spectra to obtain the fundamental physical parameters of the star. Results: We have found four frequencies which correspond to gravity modes with azimuthal order m=0,-1,-2,-3 with the same pulsational frequency in the co-rotating frame. We also found a rotational period with a frequency of 0.679 cd-1 (7.754 μHz). Conclusions: HD 50 209 is a pulsating Be star as expected from its position in the HR diagram, close to the SPB instability strip. Based on observations made with the CoRoT satellite, with FEROS at the 2.2 m telescope of the La Silla Observatory under the ESO Large Programme LP178.D-0361 and with Narval at the Télescope Bernard Lyot of the Pic du Midi Observatory. Current address: Valencian International University (VIU), José Pradas Gallen s/n, 12006 Castellón, Spain. Current address: Laboratoire AIM, CEA/DSM-CNRS-Université Paris Diderot; CEA, IRFU, SAp, centre de Saclay, 91191 Gif-sur-Yvette, France.

  2. A case of anorexia nervosa in an elderly man.

    PubMed

    Malik, Fahd; Wijayatunga, Uditha; Bruxner, George M

    2014-06-01

    To explore aspects of anorexia nervosa occurring in older populations, especially men, by reviewing the literature and presenting a case study of an elderly man with unexplained vomiting and weight loss. The literature is reviewed and an illustrative case study of an elderly man with unexplained vomiting and weight loss is described. Anorexia nervosa is an uncommon cause of unexplained weight loss in the elderly, but may be under-recognized and associated with a high level of mortality. © The Royal Australian and New Zealand College of Psychiatrists 2014.

  3. Mercury-Redstone: The first American man-rated space launch vehicle

    NASA Astrophysics Data System (ADS)

    Burkhalter, Bettye B.; Sharpe, Mitchell R.

    1990-12-01

    This paper describes the development of the Mercury-Redstone launch vehicle used by the U.S.A. in 1961 to project two manned spacecraft along suborbital ballistic trajectories. It shows that progress in ballistic missile technology dating from World War II contributed to the development of the Redstone missile, which itself was adapted for the Mercury spacecraft launch missions. Among other subjects, the proposal to use a modified Redstone as a manned launch vehicle in the proposed project Adam is recounted as is the role played by the Hermes C1. Particular attention is focused on the engineering adaptations and rigid reliability program of the Redstone missile to fulfill the requirements of launching man. The process of "man-rating" the Mercury-Redstone for this category of mission is explained. Also described are the design, development, and testing procedures developed for Mercury-Redstone. Key points in the design process and decisions made to insure mission success and astronaut safety are reviewed. Finally, the results of the flights of the Mercury Freedom 7 spacecraft piloted by Astronaut Alan B. Shepard on 6 May 1961 and the Mercury Liberty Bell 7 spacecraft piloted by Astronaut Virgil I. Grissom on 21 July 1961 are summarized.

  4. CoRoT 101186644: A transiting low-mass dense M-dwarf on an eccentric 20.7-day period orbit around a late F-star. Discovered in the CoRoT lightcurves

    NASA Astrophysics Data System (ADS)

    Tal-Or, L.; Mazeh, T.; Alonso, R.; Bouchy, F.; Cabrera, J.; Deeg, H. J.; Deleuil, M.; Faigler, S.; Fridlund, M.; Hébrard, G.; Moutou, C.; Santerne, A.; Tingley, B.

    2013-05-01

    We present the study of the CoRoT transiting planet candidate 101186644, also named LRc01_E1_4780. Analysis of the CoRoT lightcurve and the HARPS spectroscopic follow-up observations of this faint (mV = 16) candidate revealed an eclipsing binary composed of a late F-type primary (Teff = 6090 ± 200 K) and a low-mass, dense late M-dwarf secondary on an eccentric (e = 0.4) orbit with a period of ~20.7 days. The M-dwarf has a mass of 0.096 ± 0.011 M⊙, and a radius of 0.104-0.006+0.026 R⊙, which possibly makes it the smallest and densest late M-dwarf reported so far. Unlike the claim that theoretical models predict radii that are 5-15% smaller than measured for low-mass stars, this one seems to have a radius that is consistent and might even be below the radius predicted by theoretical models. Based on observations made with the 1-m telescope at the Wise Observatory, Israel, the Swiss 1.2-m Leonhard Euler telescope at La Silla Observatory, Chile, the IAC-80 telescope at the Observatory del Teide, Canarias, Spain, and the 3.6-m telescope at La Silla Observatory (ESO), Chile (program 184.C-0639).

  5. Environmental control and life support technologies for advanced manned space missions

    NASA Technical Reports Server (NTRS)

    Powell, F. T.; Wynveen, R. A.; Lin, C.

    1986-01-01

    Regenerative environmental control and life support system (ECLSS) technologies are found by the present evaluation to have reached a degree of maturity that recommends their application to long duration manned missions. The missions for which regenerative ECLSSs are attractive in virtue of the need to avoid expendables and resupply requirements have been identified as that of the long duration LEO Space Station, long duration stays at GEO, a permanently manned lunar base (or colony), manned platforms located at the earth-moon libration points L4 or L5, a Mars mission, deep space exploration, and asteroid exploration. A comparison is made between nonregenerative and regenerative ECLSSs in the cases of 10 essential functions.

  6. Light up the "no-man's land" on the brain stem.

    PubMed

    Kawase, T

    1995-12-01

    The ventral surface of the brain stem is anatomically surrounded by the clivus anteriorly, brain stem posteriorly and by the petrous pyramid and cranial nerves from IIIrd to XIIth laterally in the deep posterior cranial fossa. Neurosurgical extra-axial pathologies arising from the area are aneurysms on the vertebro-basilar artery, benign tumors such as clival meningiomas, chordomas, chondromas, trigeminal neurinomas and prepontine epidermoid tumors. Surgical access to the area had been difficult for long years since the neurosurgery was established, because located deeply in such a surgical blindness, so-called "no-man's land". However, recent technical development of "skull base surgery" is opening new doors to light up the surgical darkness of the "no-man's land". This paper reviews the history, development, technique and future prospect of the skull base surgery to open the "no-man's land".

  7. Man and his spaceships

    PubMed Central

    Siefert, Janet L.

    2012-01-01

    The resiliency and adaptive ability of microbial life in real time on Earth relies heavily upon horizontal gene transfer. Based on that knowledge, how likely is earth based microbial life to colonize extraterrestrial targets such as Mars? To address this question, we consider manned and unmanned space exploration, the resident microbiota that is likely to inhabit those vehicles, the adaptive potential of that microbiota in an extraterrestrial setting especially with regards to mobile genetic elements, and the likelihood that Mars like environments could initiate and sustain colonization. PMID:23481263

  8. The metabolites of cyclohexylamine in man and certain animals

    PubMed Central

    Renwick, A. G.; Williams, R. T.

    1972-01-01

    1. [1-14C]Cyclohexylamine hydrochloride was synthesized and given orally or intraperitoneally to rats, rabbits and guinea pigs (dose 50–500mg/kg) and orally to humans (dose 25 or 200mg/person). The 14C is excreted mainly in the urine, most of the excretion occurring in the first day after dosing. Only small amounts (1–7%) are found in the faeces. 2. In the rat, guinea pig and man, the amine is largely excreted unchanged, only 4–5% of the dose being metabolized in 24h in the rat and guinea pig and 1–2% in man. In the rabbit about two-thirds of the dose is excreted unchanged and about 30% is metabolized. 3. In the rat, five minor metabolites were found, namely cyclohexanol (0.05%), trans-3- (2.2%), cis-4- (1.7%), trans-4- (0.5%) and cis-3-aminocyclohexanol (0.1% of the dose in 24h). 4. In the rabbit, eight metabolites were identified, namely cyclohexanol (9.3%), trans-cyclohexane-1,2-diol (4.7%), cyclohexanone (0.2%), cyclohexylhydroxylamine (0.2%) and trans-3- (11.3%), cis-3- (0.6%), trans-4- (0.4%) and cis-4-aminocyclohexanol (0.2%). 5. In the guinea pig, six minor metabolites were found, namely cyclohexanol (0.5%), trans-cyclohexane-1,2-diol (2.5%) and trans-3- (1.2%), cis-3- (0.2%), trans-4- (0.2%) and cis-4-aminocyclohexanol (0.2%). 6. In man only two metabolites were definitely identified, namely cyclohexanol (0.2%) and trans-cyclohexane-1,2-diol (1.4% of the dose), but man had been given a smaller dose (3mg/kg) than the other species (50mg/kg). 7. The hydroxylated metabolites of cyclohexylamine were excreted in the urine in both free and conjugated forms. 8. Although cyclohexylamine is metabolized to only a minor extent, in rats the metabolism was mainly through hydroxylation of the cyclohexane ring, in man by deamination and in guinea pigs and rabbits by ring hydroxylation and deamination. PMID:4655821

  9. The Rickettsial Diseases of Man

    DTIC Science & Technology

    1977-01-01

    man, and in parts of Canada, Mexico , Central and South America. blood (obtained prior to initiation of antibiotic therapy) is al- Currently, RMSF is...tunica vaginalis are tissues of propagated in the yolk sacs of chicken embryos. choice for serial passage of rickettsiae. There is consider- Disease in...will agent Rochalimeea quintana have recently been identified be described in the following paragraphs. For a comprehen- in Tunisia and Mexico . The

  10. 46 CFR 97.13-1 - Muster lists, emergency signals, and manning.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Muster lists, emergency signals, and manning. 97.13-1 Section 97.13-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS OPERATIONS Station Bills § 97.13-1 Muster lists, emergency signals, and manning. The requirements for muster lists, emergency signals, an...

  11. Ssang Yong 2014 Remote Sensing Experiment

    DTIC Science & Technology

    2016-05-25

    determination of the wet field density of soil. Dry density is calculated after the laboratory measurement of the field moisture content...28 Figure 5-9. Drying ovens used in field laboratory established...seasons. Winters are usually long, cold, and dry . Summers are generally short, hot, and humid. Spring and autumn are pleasant but short in duration

  12. 'The Elephant Man' as 'self' and 'other': the psycho-social costs of a misdiagnosis.

    PubMed

    Ablon, J

    1995-06-01

    'The Elephant Man's Disease' acquired enormous notoriety through the portrayals of the life of Joseph Merrick, 'The Elephant Man', on American stage, screen and television. These portrayals, inspired by Ashley Montagu's book, The Elephant Man (1971) parleyed the designation of Merrick's condition into a household phrase, a metaphor for the grimmest extreme of ugliness. This paper explores the impact of 'The Elephant Man' as the chief referent and role model for persons who believed they shared the condition of neurofibromatosis 1, a neurological genetic disorder, which was erroneously believed at the time his story was popularized to have affected Joseph Merrick. Data were gathered through interviews with sixty affected individuals and families about their responses to the media representations of 'The Elephant Man'. Informants were recruited from three NF Support Groups and two urban hospital caseloads in Northern California.

  13. Man's Search: English, Mythology. 5112.22.

    ERIC Educational Resources Information Center

    Gundersheimer, Lenore C.

    A course which is an exploration of man's eternal search to understand himself and his world through the study of the mythology of the world is presented. Performance objectives include: (1) Students will recognize the content of the myths studied; (2) Students will identify the specific characteristics of the civilization studied; (3) Students…

  14. Genetic Engineering: The Modification of Man

    ERIC Educational Resources Information Center

    Sinsheimer, Robert L.

    1970-01-01

    Describes somatic and genetic manipulations of individual genotypes, using diabetes control as an example of the first mode that is potentially realizable be derepression or viral transduction of genes. Advocates the use of genetic engineering of the second mode to remove man from his biological limitations, but offers maxims to ensure the…

  15. Man's Response to the Physical Environment.

    ERIC Educational Resources Information Center

    Kates, R.W., Ed.; Wohlwill, J.F., Ed.

    1966-01-01

    Architects, psychologists, geographers, and biologists discuss the impact of the physical environment on man, and his adaptation to it. Article titles are as follows--(1) Galloping Technology, A New Social Disease, (2) Stimulus and Symbol: The View from the Bridge, (3) The Physical Environment: A Problem for a Psychology of Stimulation, (4)…

  16. The Language of Man. Book 5.

    ERIC Educational Resources Information Center

    Littell, Joseph Fletcher, Ed.

    This textbook part of "The Language of Man" series, is intended for use in grade 11 and above. Its four sections, each of which contains several articles, deal with body language, developing vocabulary, the dialects of English (including features on New England, Midwestern, and Southern speech, Yiddish, Kentucky speech, the talk of the…

  17. Glycoprotein synthesis in yeast. Identification of Man8GlcNAc2 as an essential intermediate in oligosaccharide processing.

    PubMed

    Byrd, J C; Tarentino, A L; Maley, F; Atkinson, P H; Trimble, R B

    1982-12-25

    Synthesis of the N-linked oligosaccharides of Saccharomyces cerevisiae glycoproteins has been studied in vivo by labeling with [2-3H]mannose and gel filtration analysis of the products released by endoglycosidase H. Both small oligosaccharides, Man8-14GlcNAc, and larger products, Man greater than 20GlcNAc, were labeled. The kinetics of continuous and pulse-chase labeling demonstrated that Glc3Man9GlcNAc2, the initial product transferred to protein, was rapidly (t1/2 congruent to 3 min) trimmed to Man8GlcNAc2 and then more slowly (t1/2 = 10-20 min) elongated to larger oligosaccharides. No oligosaccharides smaller than Man8GlcNAc2 were evident with either labeling procedure. In confirmation of the trimming reaction observed in vivo, 3H-labeled Man9-N-acetylglucosaminitol from bovine thyroglobulin and [14C]Man9GlcNAc2 from yeast oligosaccharide-lipid were converted in vitro by broken yeast cells to 3H-labeled Man8-N-acetylglucosaminitol and [14C]Man8GlcNAc2. Man8GlcNAc and Man9GlcNAc from yeast invertase and from bovine thyroglobulin were purified by gel filtration and examined by high field 1H-NMR analysis. Invertase Man8GlcNAc (B) and Man9GlcNAc (C) were homogeneous compounds, which differed from the Man9GlcNAc (A) of thyroglobulin by the absence of a specific terminal alpha 1,2-linked mannose residue. The Man9GlcNAc of invertase (C) had an additional terminal alpha 1,6-linked mannose and appeared identical in structure with that isolated from yeast containing the mnn1 and mnn2 mutations (Cohen, R. E., Zhang, W.-j., and Ballou, C. E. (1982) J. Biol. Chem. 257, 5730-5737). It is concluded that Man8GlcNAc2, formed by removal of glucose and a single mannose from Glc3Man9GlcNAc2, is the ultimate product of trimming and the minimal precursor for elongation of the oligosaccharides on yeast glycoproteins. The results suggest that removal of a particular terminal alpha 1,2-linked mannose from Man9GlcNAc2 by a highly specific alpha-mannosidase exposes the nascent Man-alpha 1

  18. Wash water reclamation technology for advanced manned spacecraft

    NASA Technical Reports Server (NTRS)

    Putnam, D. F.

    1977-01-01

    The results of an analytical study and assessment of state-of-the-art wash water reclamation technology for advanced manned spacecraft is presented. All non-phase-change unit operations, unit processes, and subsystems currently under development by NASA are considered. Included among these are: filtration, ultrafiltration, carbon adsorption, ion exchange, chemical pretreatment, reverse osmosis, hyperfiltration, and certain urea removal techniques. Performance data are given together with the projected weights and sizes of key components and subsystems. In the final assessment, a simple multifiltration approach consisting of surface-type cartridge filters, carbon adsorption and ion exchange resins receives the highest rating for six-man orbital missions of up to 10 years in duration.

  19. Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells.

    PubMed

    Mahon, T M; Matthews, J S; O'Neill, L A

    1997-07-01

    Protein kinase C (PKC) has been implicated in interleukin 1 (IL1) signal transduction in a number of cellular systems, either as a key event in IL1 action or as a negative regulator. Here we have examined the effects of two PKC inhibitors, staurosporine and the more selective agent Ro 31-8220, on IL1 responses in the murine thymoma line EL4.NOB-1. A 1 h pulse of staurosporine was found to strongly potentiate the induction of IL2 by IL1alpha in these cells. In contrast, neither a pulse nor prolonged incubation with Ro 31-8220 affected the response to IL1alpha. Both agents blocked the response to PMA, however. A 1 h pulse of staurosporine was also found to induce IL2 production on its own, activate the transcription factor nuclear factor kappaB (NFkappaB) and increase the expression of a NFkappaB-linked reporter gene. It synergized with IL1alpha in all of these responses. Ro 31-8220 was again without effect, although both staurosporine and Ro 31-8220 blocked the activation of NFkappaB by PMA. Finally, staurosporine caused the translocation of PKC-alpha and -epsilon, and to a lesser extent PKC-beta, but not PKC-θ or -zeta, from the cytosol to the membrane, although a similar effect was observed with Ro 31-8220. The results suggest that PKC is not involved in IL1alpha signalling in EL4 cells. Furthermore, the potentiating effect of staurosporine on IL1alpha action does not involve PKC inhibition, and is likely to be at the level of NFkappaB activation.

  20. 3D morphological characterization of the polyamide active layer of RO and NF membranes using TEM and soft X-ray scattering

    NASA Astrophysics Data System (ADS)

    Culp, Tyler; Paul, Mou; Roy, Abhishek; Rosenberg, Steve; Behr, Michael; Kumar, Manish; Gomez, Enrique; Penn State Team; Dow Team

    Polyamide-based thin-film composite (TFC) membranes used for reverse osmosis (RO) and nanofiltration (NF) separation processes are at the forefront of water desalination and purification technologies due to their high salt rejection, high energy efficiency, and ease of operation. Nevertheless, in spite of the benefits of RO and NF membranes, many open questions about the internal nanostructure of the membrane active layer remain, such as the dispersion and distribution of acid functional groups. We demonstrate that resonant soft X-ray scattering (RSOXS), where the X-ray energy is tuned to absorption edges of the constituent materials, is a powerful tool to examine the microstructure of the polyamide layer. In conjunction with complementary techniques such as transmission electron microscopy (TEM), where tomography is used to obtain a 3D reconstruction of the polyamide active layer, the effect of cross-linking can be quantified in 3D for a systematic series of membranes. This relationship can then be applied to a series of commercially available RO and NF membranes where the effect of polyamide cross-linking on their respective structure and water transport properties can be evaluated. The combination of RSOXS with traditional characterization tools provides a strategy for linking the chemical structure to the morphology and water transport properties of RO and NF membranes.