Colleges and Universities in the New York Metropolitan Area: Rapid Growth in Employment and Wages. Regional Report. Summary 09-09

ERIC Educational Resources Information Center

Harcum, Emily

2009-01-01

When people think of New York, Wall Street and Broadway theaters come to mind most often but in fact the New York area is also a major center for higher education. Indeed, the New York metropolitan area is home to more than 240 private colleges and universities employing about 97,000 workers and attracting students and faculty from around the…

Solar dimming and urban aerosol distribution in New York Metropolitan area

NASA Astrophysics Data System (ADS)

Hannon, P.; Liepert, B.; Chillrud, S. N.

2004-12-01

One impact of human activities on the urban and suburban environment is the dimming of sunlight due to urban air pollution and intensified haze. The spreading of urban aerosol and the optical efficiency depends on the size distribution of the particles and the vertical distribution. Reduced transparency of the atmosphere leads to an increase in scattered light compared to direct sunlight and an overall reduced total solar flux at the surface due to absorption in the atmosphere and backscattering of light to space. The modified solar flux cools the surface and suppresses evaporation and turbulent mass exchange in urban and suburban areas. Increase in diffuse sunlight can also have a positive effect on plant productivity due to increased actinic flux. Hence consequences for the biogeochemical cycles can be expected in urban and suburban areas. The quantification and variability of these effects were investigated in a pilot project in summer 2003 and 2004 where measurements of Aerosol Optical Thickness (AOT) at several wavelengths and particle number concentration for multiple size ranges were made in pilot fashion with the initial goal of better understanding horizontal and vertical distribution of aerosols near a major metropolitan center. Large spatial variability of atmospheric transparency in the New York Metropolitan area was observed in transects through New York City and Long Island to New Jersey in a field campaign in July 2003. Vertical profiles of AOT and particle number concentration were collected on board hot-air balloon flights in July 2004 that were launched from rural/suburban New Jersey. One evening flight was made in clear conditions and 4 evening flights where made under varying hazy conditions with the sunphotometer looking west. One sunrise flight was made in hazy conditions with the sunphotometer looking east through the city. Here we highlight a few results from two evening flights; additional data and plans of future work will be discussed in

Habitat improvement costs on state-owned wildlife management areas in New York

Treesearch

Ronald J. Glass

1989-01-01

Estimates of management costs on New York's wildlife management areas indicate that human management is more costly than habitat management. Agricultural agreements and timber sales make a major contribution to habitat inhancement, and a wide variety of wildlife species benefit.

Population Change Within Nonmetropolitan and Metropolitan Areas: Lessons from New York State.

ERIC Educational Resources Information Center

Moore, Dan E.

According to the results of an in-depth study of the process of population change in New York State, the less densely settled an area, the more likely it is to grow in the 1970's. This is more evidence of the recent major U.S. demographic phenomenon of a revival of population growth in non-metropolitan areas. Population data for the sixty-two…

76 FR 5679 - Emerald Ash Borer; Addition of Quarantined Areas in Kentucky, Michigan, Minnesota, New York...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-02

...;Prices of new books are listed in the first FEDERAL REGISTER issue of each #0;week. #0; #0; #0; #0;#0...-0098] Emerald Ash Borer; Addition of Quarantined Areas in Kentucky, Michigan, Minnesota, New York..., Minnesota, New York, Pennsylvania, Wisconsin, and the entire State of West Virginia to the list of...

Blood-based NfL

PubMed Central

Janelidze, Shorena; Hall, Sara; Magdalinou, Nadia; Lees, Andrew J.; Andreasson, Ulf; Norgren, Niklas; Linder, Jan; Forsgren, Lars; Constantinescu, Radu; Zetterberg, Henrik; Blennow, Kaj

2017-01-01

Objective: To determine if blood neurofilament light chain (NfL) protein can discriminate between Parkinson disease (PD) and atypical parkinsonian disorders (APD) with equally high diagnostic accuracy as CSF NfL, and can therefore improve the diagnostic workup of parkinsonian disorders. Methods: The study included 3 independent prospective cohorts: the Lund (n = 278) and London (n = 117) cohorts, comprising healthy controls and patients with PD, progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA), as well as an early disease cohort (n = 109) of patients with PD, PSP, MSA, or CBS with disease duration ≤3 years. Blood NfL concentration was measured using an ultrasensitive single molecule array (Simoa) method, and the diagnostic accuracy to distinguish PD from APD was investigated. Results: We found strong correlations between blood and CSF concentrations of NfL (ρ ≥ 0.73–0.84, p ≤ 0.001). Blood NfL was increased in patients with MSA, PSP, and CBS (i.e., all APD groups) when compared to patients with PD as well as healthy controls in all cohorts (p < 0.001). Furthermore, in the Lund cohort, blood NfL could accurately distinguish PD from APD (area under the curve [AUC] 0.91) with similar results in both the London cohort (AUC 0.85) and the early disease cohort (AUC 0.81). Conclusions: Quantification of blood NfL concentration can be used to distinguish PD from APD. Blood-based NfL might consequently be included in the diagnostic workup of patients with parkinsonian symptoms in both primary care and specialized clinics. Classification of evidence: This study provides Class III evidence that blood NfL levels discriminate between PD and APD. PMID:28179466

77 FR 58469 - Asian Longhorned Beetle; Quarantined Areas in Massachusetts, Ohio, and New York

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-21

... Worcester County, MA, and Clermont County, OH, to the list of quarantined areas in Sec. 301.51-3(c). In... Islip, Suffolk County, NY, from the list of quarantined areas in Sec. 301.51-3(c) based on our.... APHIS-2012-0003] Asian Longhorned Beetle; Quarantined Areas in Massachusetts, Ohio, and New York AGENCY...

77 FR 31720 - Asian Longhorned Beetle; Quarantined Areas in Massachusetts, Ohio, and New York

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-30

.... APHIS-2012-0003] Asian Longhorned Beetle; Quarantined Areas in Massachusetts, Ohio, and New York AGENCY...: We are amending the Asian longhorned beetle regulations to make changes to the list of quarantined... the artificial spread of Asian longhorned beetle to noninfested areas of the United States and to...

76 FR 1337 - Asian Longhorned Beetle; Additions to Quarantined Areas in Massachusetts and New York

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-10

... Worcester County, MA, to the list of quarantined areas in Sec. 301.51-3(c) and by updating the description.... APHIS-2009-0014] Asian Longhorned Beetle; Additions to Quarantined Areas in Massachusetts and New York... areas and updating the description of the quarantined area in the Borough of Staten Island in the City...

Learn about NF

MedlinePlus

... Understanding NF Neurofibromatosis Intro to NF NF1 NF2 Schwannomatosis Genetics of NF Living with NF NF Registry ... of passing the condition on to their offspring. Schwannomatosis is less well understood, but the majority of ...

Drought Risk Assessment for Greater New York Area: A Paleo View

NASA Astrophysics Data System (ADS)

Ceylan, G.; Devineni, N.

2014-12-01

The Delaware River provides half of New York City's drinking water, is a habitat for wild trout, American shad and the federally endangered dwarf wedge mussel. It has suffered four 100-year floods in the last seven years. A drought during the 1960s stands as a warning of the potential vulnerability of the New York City area to severe water shortages if a similar drought were to recur. The water releases from three New York City dams on the Delaware River's headwaters impact not only the reliability of the city's water supply, but also the potential impact of floods, and the quality of the aquatic habitat in the upper river. The goal of this work is to influence the Delaware River water release policies (FFMP/OST) to further benefit river habitat and fisheries without increasing New York City's drought risk, or the flood risk to down basin residents. The Delaware water release policies are constrained by the dictates of two US Supreme Court Decrees (1931 and 1954) and the need for unanimity among four states: New York, New Jersey, Pennsylvania, and Delaware -- and New York City. Coordination of their activities and the operation under the existing decrees is provided by the Delaware River Basin Commission (DRBC). Questions such as the probability of the system approaching drought state based on the current FFMP plan and the severity of the 1960s drought are addressed using long record paleo-reconstructions of flows. For this study, we developed reconstructed total annual flows (water year) for 3 reservoir inflows using regional tree rings going back up to 1754 (a total of 246 years). The reconstructed flows are used with a simple reservoir model to quantify droughts. We observe that the 1960s drought is by far the worst drought based on 246 years of simulations (since 1754). However, there are intermediate drought warning periods and proper adaptation would be sufficient during these periods. Modified release rules that aid thermal relief to wild trout in the upper

A Regional Approach to Rail Transit Training for the New York Metropolitan Area

DOT National Transportation Integrated Search

1991-06-01

The purpose of this project was to study the feasibility of a regional approach : to rail transit training in the New York metropolitan area and to recommend a : means for implementing such a cooperative training effort. The study had two : parts. Th...

Legalization's Second Step: The Availability of English Civics Classes in the Chicago, Houston, Miami and New York City Metropolitan Areas.

ERIC Educational Resources Information Center

National Association of Latino Elected and Appointed Officials Education Fund, Washington, DC.

This paper reports on a 1989 survey of publicly funded amnesty class capacity in the chief metropolitan areas of the four states outside of California that have the largest populations of legalization applicants. The areas covered are Chicago (Illinois), Houston (Texas), Miami (Florida), and New York (New York). The study sought to determine if…

Lipid peroxidation and apoptotic response in rat brain areas induced by long-term administration of nandrolone: the mutual crosstalk between ROS and NF-kB.

PubMed

Turillazzi, Emanuela; Neri, Margherita; Cerretani, Daniela; Cantatore, Santina; Frati, Paola; Moltoni, Laura; Busardò, Francesco Paolo; Pomara, Cristoforo; Riezzo, Irene; Fineschi, Vittorio

2016-04-01

The aim of this study was to evaluate the played by oxidative stress in the apoptotic response in different brain areas of rats chronically treated with supra-physiological doses of nandrolone decanoate (ND). Immunohistochemical study and Western blot analysis were performed to evaluate cells' apoptosis and to measure the effects of expression of specific mediators, such as NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), Bcl-2 (B-cell lymphoma 2), SMAC/DIABLO (second mitochondria-derived activator of caspases/direct IAP-binding protein with low PI) and VMAT2 (vesicular monoamine transporter 2) on apoptosis. The results of the present study indicate that a long-term administration of ND promotes oxidative injury in rat brain specific areas. A link between oxidative stress and NF-κB signalling pathways is supported by our results. In addition to high levels of oxidative stress, we consistently observed a strong immunopositivity to NF-κB. It has been argued that one of the pathways leading to the activation of NF-κB could be under reactive oxygen species (ROS)-mediated control. In fact, growing evidence suggests that although in limited doses, endogenous ROS may play an activating role in NF-κB signalling, while above a certain threshold, they may negatively impact upon this signalling. However, a mutual crosstalk between ROS and NF-κB exists and recent studies have shown that ROS activity is subject to negative feedback regulation by NF-κB, and that this negative regulation of ROS is the means through which NF-κB counters programmed cells. © 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

33 CFR 165.162 - Safety Zone: New York Super Boat Race, Hudson River, New York.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Safety Zone: New York Super Boat Race, Hudson River, New York. 165.162 Section 165.162 Navigation and Navigable Waters COAST GUARD... § 165.162 Safety Zone: New York Super Boat Race, Hudson River, New York. (a) Regulated area. The...

Quantitative risk assessment of the New York State operated West Valley Radioactive Waste Disposal Area.

PubMed

Garrick, B John; Stetkar, John W; Bembia, Paul J

2010-08-01

This article is based on a quantitative risk assessment (QRA) that was performed on a radioactive waste disposal area within the Western New York Nuclear Service Center in western New York State. The QRA results were instrumental in the decision by the New York State Energy Research and Development Authority to support a strategy of in-place management of the disposal area for another decade. The QRA methodology adopted for this first of a kind application was a scenario-based approach in the framework of the triplet definition of risk (scenarios, likelihoods, consequences). The measure of risk is the frequency of occurrence of different levels of radiation dose to humans at prescribed locations. The risk from each scenario is determined by (1) the frequency of disruptive events or natural processes that cause a release of radioactive materials from the disposal area; (2) the physical form, quantity, and radionuclide content of the material that is released during each scenario; (3) distribution, dilution, and deposition of the released materials throughout the environment surrounding the disposal area; and (4) public exposure to the distributed material and the accumulated radiation dose from that exposure. The risks of the individual scenarios are assembled into a representation of the risk from the disposal area. In addition to quantifying the total risk to the public, the analysis ranks the importance of each contributing scenario, which facilitates taking corrective actions and implementing effective risk management. Perhaps most importantly, quantification of the uncertainties is an intrinsic part of the risk results. This approach to safety analysis has demonstrated many advantages of applying QRA principles to assessing the risk of facilities involving hazardous materials.

75 FR 8486 - Regulated Navigation Area; Hudson River south of the Troy Locks, New York

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-25

...-AA11 Regulated Navigation Area; Hudson River south of the Troy Locks, New York AGENCY: Coast Guard, DHS... area on the navigable waters of the Hudson River south of the Troy Locks. This regulated navigation... Hudson River south of the Troy locks when ice conditions are 8 inches or greater unless authorized by the...

Use of hospital-based ambulatory care in New York City's Health Manpower Shortage Areas.

PubMed Central

Stager, D F; Krasner, M I; Goodwin, E J

1987-01-01

The development of a comprehensive data base for hospital-based ambulatory care has made possible the accurate determination of each community's use of hospitals in New York City and permits a reliable estimation of all ambulatory care received by residents of Health Manpower Shortage Areas (HMSAs). In spite of the city's abundant supply of private practitioners and widespread Medicaid coverage, residents of HMSAs in New York City are heavily dependent on hospital-based ambulatory care. Contrary to commonly held notions, however, HMSA residents do not appear to overuse hospital-based ambulatory care. Rather, that use appears to be quite modest, given their poorer health status. PMID:3101118

42 CFR 483.132 - Evaluating the need for NF services and NF level of care (PASARR/NF).

Code of Federal Regulations, 2010 CFR

2010-10-01

... and 483.136, the State mental health or mental retardation authority must determine whether an NF... 42 Public Health 5 2010-10-01 2010-10-01 false Evaluating the need for NF services and NF level of care (PASARR/NF). 483.132 Section 483.132 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES...

Styrene process condensate treatment with a combination process of UF and NF for reuse.

PubMed

Wang, Aijun; Liu, Guangmin; Huang, Jin; Wang, Lijuan; Li, Guangbin; Su, Xudong; Qi, Hong

2013-01-15

Aiming at reusing the SPC to save water resource and heat energy, a combination treatment process of UF/NF was applied to remove inorganic irons, suspended particles and little amount of organic contaminants in this article. To achieve the indexes of CODM≤5.00 mg L(-1), oil≤2.00 mg L(-1), conductivity≤10.00 μs cm(-1), pH of 6.0-8.0, the NF membrane process was adopted. It was necessary to employ a pretreatment process to reduce NF membrane fouling. Hence UF membrane as an efficient pretreatment unit was proposed to remove the inorganic particles, such as iron oxide catalyst, to meet the influent demands of NF. The effluent of UF, which was less than 0.02 mg L(-1) of total iron, went into a security filter and then was pumped into the NF process unit. High removal efficiencies of CODM, oil and conductivity were achieved by using NF process. The ABS grafting copolymerization experiment showed that the effluent of the combination process met the criteria of ABS production process, meanwhile the process could alleviate the environment pollution. It was shown that this combination process concept was feasible and successful in treating the SPC. Copyright © 2012 Elsevier B.V. All rights reserved.

77 FR 61723 - Felgates Creek and Indian Field Creek Along the York River in Yorktown, VA; Restricted Area

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-11

.... 334.260 York River, Va.; naval restricted areas. (a) The areas--(1) Naval mine service-testing area... thence along the shore line to the point of beginning. (2) Naval mine service-testing area (restricted... delay, except in case of emergency. Naval authorities are required to publish advance notice of mine...

STS-42 Earth observation of New York City (NYC), New York

NASA Image and Video Library

1992-01-30

STS-42 Earth observation taken aboard Discovery, Orbiter Vehicle (OV) 103, is of New York City (NYC), New York (41.0N, 74.0W). Snow cover highlights the large areas of development and the many reservoirs in this wintertime scene of the metropolitan NYC area. Features such as Central Park in Manhattan, the George Washington Bridge connecting Manhattan with New Jersey, street patterns in most of the boroughs, La Guardia and JFK airports in Queens, and the extensive harbor system are easily identified.

STS-42 Earth observation of New York City (NYC), New York

NASA Technical Reports Server (NTRS)

1992-01-01

STS-42 Earth observation taken aboard Discovery, Orbiter Vehicle (OV) 103, is of New York City (NYC), New York (41.0N, 74.0W). Snow cover highlights the large areas of development and the many reservoirs in this wintertime scene of the metropolitan NYC area. Features such as Central Park in Manhattan, the George Washington Bridge connecting Manhattan with New Jersey, street patterns in most of the boroughs, La Guardia and JFK airports in Queens, and the extensive harbor system are easily identified.

Mapping the Sea Floor of the Historic Area Remediation Site (HARS) Offshore of New York City

USGS Publications Warehouse

Butman, Bradford

2002-01-01

The area offshore of New York City has been used for the disposal of dredged material for over a century. The area has also been used for the disposal of other materials such as acid waste, industrial waste, municipal sewage sludge, cellar dirt, and wood. Between 1976 and 1995, the New York Bight Dredged Material Disposal Site, also known as the Mud Dump Site (MDS), received on average about 6 million cubic yards of dredged material annually. In September 1997 the MDS was closed as a disposal site, and it and the surrounding area were designated as the Historic Area Remediation Site (HARS). The sea floor of the HARS, approximately 9 square nautical miles in area, currently is being remediated by placing a minimum 1-m-thick cap of clean dredged material on top of the surficial sediments that are contaminated from previous disposal of dredged and other materials. The U.S. Geological Survey (USGS) is working cooperatively with the U.S. Army Corps of Engineers (USACE) to map the sea floor geology of the HARS and changes in the characteristics of the surficial sediments over time.

New York City, Hudson River, NY, USA

NASA Technical Reports Server (NTRS)

1991-01-01

This color infrared photo of New York City, Hudson River, NY, (41.0N, 74.0W) shows a unique view of the dense urban development of the New York City metropolitan area in downstate New York, Long Island and New Jersey. The heavily populated city areas appear as white or gray while vegetated areas appear as shades of red. Central park clearly shows up on Manhattan Island as an illustration of the delineation between cultural and natural features.

Integration in New York City Schools

ERIC Educational Resources Information Center

Anker, Irving

1975-01-01

The Chancellor of the New York City Board of Education discusses, in his testimony before a May 1974 public hearing of the New York City Commission on Human Rights why the goal of integration in New York City, as in other inner city areas throughout the country, remained so elusive, noting that 66 percent of public school children in New York City…

Hydrogeology of the Olean area, Cattaraugus County, New York

USGS Publications Warehouse

Zarriello, Phillip J.; Reynolds, Richard J.

1987-01-01

Most principal aquifers in upstate New York are unconsolidated glacial and alluvial deposits within bedrock valleys. Groundwater in these aquifers can be under either water table (unconfined) or artesian (confined) conditions. Farms, industries, or towns and cities have been built upon many of these aquifers because they form level areas suitable for development and generally provide an ample groundwater supply. This development, coupled with the generally high permeability of these deposits and the typically shallow depth to the water table, makes groundwater in these aquifers susceptible to contamination from point sources such as landfills, road salt stockpiles, hydrocarbon fuel storage, and industrial facilities with a potential for contaminant leakage, in addition to urban and agricultural runoff, septic tank leachate, and other nonpoint sources. The report summarizes the geohydrology of the aquifer system in the Olean area. The large amount of geohydrologic data collected in the Olean area during previous and current investigations enabled the construction of nine maps: location and wells and test holes (plate 1), surficial geology (plate 2), geologic sections (plate 3), generalized bedrock topography (plate 4), potentiometric surface (plate 5), saturated thickness of the outwash aquifer (plate 6), generalized soil permeability (plate 7), land use (plate 8), and estimated well yields (plate 9). (Lantz-PTT)

Evaluation of dredged material proposed for ocean disposal from Bronx River Project Area, New York

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gruendell, B.D.; Gardiner, W.W.; Antrim, L.D.

1996-12-01

The objective of the Bronx River project was to evaluate proposed dredged material from the Bronx River project area in Bronx, New York, to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Bronx River was one of five waterways that the US Army Corps of Engineers-New York District (USAGE-NYD) requested the Battelle Marine Sciences Laboratory (MSL) to sample and to evaluate for dredging and disposal. Sediment samples were submitted for physical and chemical analyses, chemical analyses of dredging site water and elutriate, benthic and water-column acute toxicity tests, and bioaccumulation studies. Fifteen individual sediment core samplesmore » collected from the Bronx River project area were analyzed for grain size, moisture content, and total organic carbon (TOC). One composite sediment sample, representing the entire reach of the area proposed for dredging, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAH), and 1,4- dichlorobenzene. Dredging site water and elutriate water, which was prepared from the suspended-particulate phase (SPP) of the Bronx River sediment composite, were analyzed for metals, pesticides, and PCBS.« less

NF-κB expression and its association with nutritional status in hemodialysis patients.

PubMed

Farage, Najla E; Stockler-Pinto, Milena B; Leal, Viviane O; Cardozo, Ludmila Lmf; Carraro-Eduardo, José Carlos; Fouque, Denis; Mafra, Denise

2016-12-01

This study aimed to evaluate the association among the expressions of pro- and anti-inflammatory nuclear factors (nuclear factor-kappaB, NF-κB and nuclear erythroid 2-related factor 2, Nrf2) and nutritional status in HD patients. This cross-sectional study included eighty-three HD patients. The peripheral blood mononuclear cells were isolated and processed for the evaluation of NF-κB and Nrf2 RNAm expression by quantitative real-time polymerase chain reaction. Muscle mass was estimated by creatinine index (CI) and percentage of body fat (%BF) by anthropometry. Seven-point subjective global assessment was also used to evaluate the nutritional status. The NF-κB expression was negatively correlated with CI (r = -0.54, p = 0.0001), serum albumin (r = -0.32, p = 0.02) and %BF (r = -0.61, p = 0.001). Multiple linear regression analysis revealed that NF-κB expression was independently associated with CI (β: -0.8, p = 0.013) and %BF (β: -0.42, p = 0.04). There was no correlation among Nrf2 and anthropometric and biochemical variables. The classical NF-κB activation seems to be associated with poor nutritional status in HD patients; however, the exact underlying mechanisms deserve further studies.

A Cultural Resources Survey of Proposed Project Areas in the Buffalo Harbor, Erie County, New York

DTIC Science & Technology

1984-01-01

continued warming was indicated - by the transition into the B-I Stage, with the decline of the spruce forests and an increase in birch and pine . Deciduous...County area in 1620 as part of the Plymouth Colony settlement. The claim was made again when the area was granted to the Duke of York in 1664. The first...Buffalo cleared the area in 1902 and removed the Sea Wall Strip of squatters, leaving the area " barren " (Symons and Quintus 1902: 256-257) . Between

The Nutrition and Dietetics Workforce Needs Skills and Expertise in the New York Metropolitan Area

PubMed Central

Gaba, Ann; Shrivastava, Apoorva; Amadi, Chioma; Joshi, Ashish

2016-01-01

Background: There is an increased demand in the Nutrition and Dietetics field which has fostered credentialing to ensure competent graduates. The objective of this study is to conduct an exploratory analysis to identify nutrition/dietetics workforce needs, skills and expertise in the New York metropolitan area as exemplified in position announcements over a 4 year period. Methods: We recorded position announcements for jobs in nutrition and dietetics from the New York State Registered Dietitian Yahoo group, and the Hunter College Nutrition and Food Sciences student and alumni listserv (NFS-L) over a 4 year period. Keywords were identified using job categories defined by the Academy of Nutrition and Dietetics (AND) compensation and benefits survey. This served as a starting point to enumerate the types of positions that have been posted for the New York metropolitan area in recent years. Results: Four hundred and twelve (412) unique job postings were recorded. Various educational levels, credentials, and skills desired by these employers were identified, assessed, and compared with similar data from the “supply side” reports from AND. Conclusions: The credentials and skills most desired by employers are similar to some of the learning objectives set forth for DPD and DI programs by ACEND, but not entirely congruent. The need for both client/customer focus and computer literacy may be implicit in the standards, but a more overt inclusion of these skills would likely be of benefit to ensure these are inculcated into every program and student. PMID:26755482

Noncanonical NF-κB Signaling Is Limited by Classical NF-κB Activity

PubMed Central

Gray, Carolyn M.; Remouchamps, Caroline; McCorkell, Kelly A.; Solt, Laura A.; Dejardin, Emmanuel; Orange, Jordan S.; May, Michael J.

2014-01-01

Precise regulation of nuclear factor κB (NF-κB) signaling is crucial for normal immune responses, and defective NF-κB activity underlies a range of immunodeficiencies. NF-κB is activated through two signaling cascades: the classical and noncanonical pathways. The classical pathway requires inhibitor of κB kinase β (IKKβ) and NF-κB essential modulator (NEMO), and hypomorphic mutations in the gene encoding NEMO (ikbkg) lead to inherited immunodeficiencies, collectively termed NEMO-ID. Noncanonical NF-κB activation requires NF-κB–inducing kinase (NIK) and IKKα, but not NEMO. We found that noncanonical NF-κB was basally active in peripheral blood mononuclear cells from NEMO-ID patients, and that noncanonical NF-κB signaling was similarly enhanced in cell lines lacking functional NEMO. NIK, which normally undergoes constitutive degradation, was aberrantly present in resting NEMO-deficient cells, and regulation of its abundance was rescued by reconstitution with full-length NEMO, but not a mutant NEMO protein unable to physically associate with IKKα or IKKβ. Binding of NEMO to IKKα was not required for ligand-dependent stabilization of NIK or noncanonical NF-κB signaling. Rather, an intact and functional IKK complex was essential to suppress basal NIK activity in unstimulated cells. Despite interacting with IKKα and IKKβ to form an IKK complex, NEMO mutants associated with immunodeficiency failed to rescue classical NF-κB signaling or reverse the accumulation of NIK. Together, these findings identify a crucial role for classical NF-κB activity in the suppression of basal noncanonical NF-κB signaling. PMID:24497610

Gender differences in psychological reactions to Hurricane Sandy among New York Metropolitan Area residents.

PubMed

Hamama-Raz, Yaira; Palgi, Yuval; Shrira, Amit; Goodwin, Robin; Kaniasty, Krzysztof; Ben-Ezra, Menachem

2015-06-01

Hurricane Sandy was a natural disaster of large proportions--a category 3 storm at its peak intensity that struck New York Metropolitan Area on October, 2012. The death and destruction caused by a hurricane can rise numerous of mental health vulnerabilities such as, acute stress disorder, posttraumatic stress disorder, depression, and anxiety. Gender has been identified as one critical variable that can impact vulnerability to adverse effects of trauma, as well as how these reactions are managed. The present research provides an evaluation of gender differences regarding posttraumatic stress symptoms, recollections of national disasters and fears of future negative life events. It also aims to explore information seeking and sources of assistance that were utilized during Hurricane Sandy. An online survey sample of 1,000 people from New York Metropolitan Area completed a battery of self-report questionnaires four weeks after the storm. Results revealed that recollections of national disaster and fear of future events were found to be significantly different among women compared to men. Additionally, women were more inclined toward information seeking through Facebook than men, although no gender differences emerged when examining sources of support. The results indicate that disaster practitioners should tailor gender sensitive interventions.

Food and Waterborne Disease in the Greater New York City Area Following Hurricane Sandy in 2012.

PubMed

Bloom, Michael S; Palumbo, Jillian; Saiyed, Nazia; Lauper, Ursula; Lin, Shao

2016-06-01

We aimed to evaluate residence in evacuation areas (storm areas) as a risk factor for food and waterborne disease (FWBD) associated with Hurricane Sandy flooding. We captured 9601 incident outpatient and inpatient FWBD hospital discharge diagnoses for residents of the greater New York City area. We used Poisson or negative binomial regression models to compare the covariate-adjusted risk for a FWBD diagnosis, pre-Sandy (10/28-11/09, 2001-2011) vs. post-Sandy (10/28-11/09, 2012), for residents of "storm" and "non-storm" areas. Outpatient FWBD risk was lower for storm area residents after Hurricane Sandy (risk ratio [RR]=0.58, 95% confidence interval [CI]: 0.46-0.74), and varied by age, sex, and county. However, storm area residents 65 years of age or older experienced higher risk after Hurricane Sandy (RR=2.16, 95% CI: 1.11-4.19), albeit based on few cases. Inpatient FWBD risk was lower for non-storm area residents after Hurricane Sandy (RR=0.79, 95% CI: 0.66-0.95), and varied by age, race, and county, although there was no significant change for storm area residents (RR=0.86, 95% CI: 0.69-1.08). Those ≥65 years of age were also at lower risk for inpatient FWBD diagnosis, yet the effect was weaker for storm area (RR=0.89, 95% CI: 0.67-1.18) than for non-storm area residents (RR=0.68, 95% CI: 0.52-0.89). Hurricane preparation, mitigation, and response activities in the greater New York City area may have led to "protective" effects for FWBD. (Disaster Med Public Health Preparedness. 2016;10:503-511).

New York City, Hudson River, NY, USA

NASA Image and Video Library

1991-05-06

STS039-88-054 (28 April-6 May 1991) --- The dense urban development of the New York City metropolitan area in downstate New York, Long Island and New Jersey shows up as gray and white on this color Infrared photograph. The scene was taken on a remarkably clear spring day. Almost all the major man-made structures of the area are obvious, including ship traffic in and out of New York Harbor, the piers, all of the bridges spanning the area rivers and connecting Manhattan Island with New Jersey, the Bronx, Brooklyn and Queens, the three major airports (Newark, La Guardia and JFK), the New York State thruway, as well as Shea Stadium and Yankee Stadium. The reds and pinks are vegetated areas. Central Park clearly shows up on Manhattan, as do the string of parks along the cliffs (formed by the Palisades sill) along the west side of the Hudson north of the George Washington Bridge.

Buffalo Metropolitan Area, New York Water Resources Management Study, Tonawanda Creek Watershed. Interim Flood Management Study. Appendices.

DTIC Science & Technology

1980-12-01

direction w~ih: A HE M a 6 peak dicg cft I pows TONAWANDA CREEK WATERSHED. NEW YORK MARCH 1960 FLOODED AREAS* FLOODLANO IN THE CITY OF BATAVIA AND...AREA CURVES4: 7 Uas. Aitem teivals~ DISuICT. UWFALO 00 200 DRAINIAGE AREA INf SQ. /IILES PLATE AMl V......... . u;t 99,li:k- - - - %;: :.z...NY State Geological Assn., p. 116. Grossman, William L., 1938, Geology of the Caledonia Quadrangle, M. A. Thesis University of Rochester. Kindle, E. M

Vascular Plant Species of the Forest Ecology Research and Demonstration Area, Paul Smith's, New York

Treesearch

Gary L. Wade; Jonathan A. Myers; Cecilia R. Martin; Kathie Detmar; William, III Mator; Mark J. Twery; Mike Rechlin

2003-01-01

Five forest harvest methods (single-tree selection, group selection, two-age cut, shelterwood cut, and clearcut) are being demonstrated on 5-acre tracts near the Adirondack Park Agency?s Visitor Interpretation Center (VIC) at Paul Smith?s, New York. The tracts are part of the agency?s Forest Ecology Research and Demonstration Area. A primary goal is to show visitors...

Floods of 2011 in New York

USGS Publications Warehouse

Lumia, Richard; Firda, Gary D.; Smith, Travis L.

2014-01-01

Record rainfall combined with above-average temperatures and substantial spring snowmelt resulted in record flooding throughout New York during 2011. Rainfall totals in eastern New York were the greatest since 1895 and as much as 60 percent above the long-term average within the Catskill Mountains area and the Susquehanna River Basin. This report documents the three largest storms and resultant flooding during the year: (1) spring storm during April and May, (2) Tropical Storm Irene during August, and (3) remnants of Tropical Storm Lee during September. According to the Federal Emergency Management Agency (FEMA), the cost of these three storms exceeded $1 billion in Federal disaster assistance. A warm and wet spring in northern New York resulted in record flooding at 21 U.S. Geological Survey (USGS) active streamgages during late April to early May with the annual exceedance probabilities (AEPs) of 11 peak discharges equaling or exceeding 1 percent. Nearly 5 inches of rain during late April combined with a rapidly melting snowpack caused widespread flooding throughout northern New York, resulting in many road closures, millions of dollars in damages, and 23 counties declared disaster areas and eligible for public assistance. On May 6, Lake Champlain recorded its highest lake level in over 140 years. Hurricane Irene entered New York State on August 28 as a tropical storm and traveled up the eastern corridor of the State, leaving a path of destruction and damage never seen in many parts of New York. Thirty-one counties in New York were declared disaster areas with damages of over $1.3 billion dollars and 10 reported deaths. Storm rainfall exceeded 18 inches in the Catskill Mountains area of southeastern New York with many other areas of eastern New York receiving over 7 inches. Catastrophic flooding resulted from the extreme rainfall in many locations, including Schoharie Creek and its tributaries, the eastern Delaware River Basin, the Ausable and Bouquet River

49 CFR 372.235 - New York, NY.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 5 2010-10-01 2010-10-01 false New York, NY. 372.235 Section 372.235... ZONES, AND TERMINAL AREAS Commercial Zones § 372.235 New York, NY. The zone adjacent to, and commercially a part of, New York, NY, within which transportation by motor vehicle, in interstate or foreign...

Requirement of NF-kappa B Activation in Different Mice Brain Areas during Long-Term Memory Consolidation in Two Contextual One-Trial Tasks with Opposing Valences

PubMed Central

Salles, Angeles; Krawczyk, Maria del C.; Blake, Mariano; Romano, Arturo; Boccia, Mariano M.; Freudenthal, Ramiro

2017-01-01

NF-kappa B is a transcription factor whose activation has been shown to be necessary for long-term memory consolidation in several species. NF-kappa B is activated and translocates to the nucleus of cells in a specific temporal window during consolidation. Our work focuses on a one trial learning tasks associated to the inhibitory avoidance (IA) setting. Mice were trained either receiving or not a footshock when entering a dark compartment (aversive vs. appetitive learning). Regardless of training condition (appetitive or aversive), latencies to step-through during testing were significantly different to those measured during training. Additionally, these testing latencies were also different from those of a control group that only received a shock unrelated to context. Moreover, nuclear NF-kappa B DNA-binding activity was augmented in the aversive and the appetitive tasks when compared with control and naïve animals. NF-kappa B inhibition by Sulfasalazine injected either in the Hippocampus, Amygdala or Nucleus accumbens immediately after training was able to impair retention in both training versions. Our results suggest that NF-kappa B is a critical molecular step, in different brain areas on memory consolidation. This was the case for both the IA task and also the modified version of the same task where the footshock was omitted during training. This work aims to further investigate how appetitive and aversive memories are consolidated. PMID:28439227

OsNF-YC2 and OsNF-YC4 proteins inhibit flowering under long-day conditions in rice.

PubMed

Kim, Soon-Kap; Park, Hyo-Young; Jang, Yun Hee; Lee, Keh Chien; Chung, Young Soo; Lee, Jeong Hwan; Kim, Jeong-Kook

2016-03-01

OsNF-YC2 and OsNF-YC4 proteins regulate the photoperiodic flowering response through the modulation of three flowering-time genes ( Ehd1, Hd3a , and RFT1 ) in rice. Plant NUCLEAR FACTOR Y (NF-Y) transcription factors control numerous developmental processes by forming heterotrimeric complexes, but little is known about their roles in flowering in rice. In this study, it is shown that some subunits of OsNF-YB and OsNF-YC interact with each other, and among them, OsNF-YC2 and OsNF-YC4 proteins regulate the photoperiodic flowering response of rice. Protein interaction studies showed that the physical interactions occurred between the three OsNF-YC proteins (OsNF-YC2, OsNF-YC4 and OsNF-YC6) and three OsNF-YB proteins (OsNF-YB8, OsNF-YB10 and OsNF-YB11). Repression and overexpression of the OsNF-YC2 and OsNF-YC4 genes revealed that they act as inhibitors of flowering only under long-day (LD) conditions. Overexpression of OsNF-YC6, however, promoted flowering only under LD conditions, suggesting it could function as a flowering promoter. These phenotypes correlated with the changes in the expression of three rice flowering-time genes [Early heading date 1 (Ehd1), Heading date 3a (Hd3a) and RICE FLOWERING LOCUS T1 (RFT1)]. The diurnal and tissue-specific expression patterns of the subsets of OsNF-YB and OsNF-YC genes were similar to those of CCT domain encoding genes such as OsCO3, Heading date 1 (Hd1) and Ghd7. We propose that OsNF-YC2 and OsNF-YC4 proteins regulate the photoperiodic flowering response by interacting directly with OsNF-YB8, OsNF-YB10 or OsNF-YB11 proteins in rice.

Functional conservation of rice OsNF-YB/YC and Arabidopsis AtNF-YB/YC proteins in the regulation of flowering time.

PubMed

Hwang, Yoon-Hyung; Kim, Soon-Kap; Lee, Keh Chien; Chung, Young Soo; Lee, Jeong Hwan; Kim, Jeong-Kook

2016-04-01

Rice Os NF - YB and Os NF - YC complement the late flowering phenotype of Arabidopsis nf - yb double and nf - yc triple mutants, respectively. In addition, OsNF-YB and OsNF-YC interact with AtNF-YC and AtNF-YB, respectively. Plant NUCLEAR FACTOR Y (NF-Y) transcription factors play important roles in plant development and abiotic stress. In Arabidopsis thaliana, two NF-YB (AtNF-YB2 and AtNF-YB3) and five NF-YC (AtNF-YC1, AtNF-YC2, AtNF-YC3, AtNF-YC4, and AtNF-YC9) genes regulate photoperiodic flowering by interacting with other AtNF-Y subunit proteins. Three rice NF-YB (OsNF-YB8, OsNF-YB10, and OsNF-YB11) and five rice OsNF-YC (OsNF-YC1, OsNF-YC2, OsNF-YC4, OsNF-YC6, and OsNF-YC7) genes are clustered with two AtNF-YB and five AtNF-YC genes, respectively. To investigate the functional conservation of these NF-YB and NF-YC genes in rice and Arabidopsis, we analyzed the flowering phenotypes of transgenic plants overexpressing the respective OsNF-YB and OsNF-YC genes in Arabidopsis mutants. Overexpression of OsNF-YB8/10/11 and OsNF-YC2 complemented the late flowering phenotype of Arabidopsis nf-yb2 nf-yb3 and nf-yc3 nf-yc4 nf-yc9 mutants, respectively. The rescued phenotype of 35S::OsNF-YC2 nf-yc3 nf-yc4 nf-yc9 plants was attributed to the upregulation of FLOWERING LOCUS T (FT) and SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1). In vitro and in planta protein-protein analyses revealed that OsNF-YB8/10/11 and OsNF-YC1/2/4/6/7 interact with AtNF-YC3/4/9 and AtNF-YB2/3, respectively. Our data indicate that some OsNF-YB and OsNF-YC genes are functional equivalents of AtNF-YB2/3 and AtNF-YC3/4/9 genes, respectively, and suggest functional conservation of Arabidopsis and rice NF-Y genes in the control of flowering time.

New York: Multi-Speak City!

ERIC Educational Resources Information Center

New York City Economic Development Council, NY.

This guide was written to help teachers make students aware of the multilingual and multi-ethnic nature of New York City in order to experience and explore different languages and customs. New York is a center for variety in language and culture in the areas of diplomacy, international commerce, media and communications, foods and fashion, the…

Double NF1 Inactivation Affects Adrenocortical Function in NF1Prx1 Mice and a Human Patient

PubMed Central

Kobus, Karolina; Hartl, Daniela; Ott, Claus Eric; Osswald, Monika; Huebner, Angela; von der Hagen, Maja; Emmerich, Denise; Kühnisch, Jirko; Morreau, Hans; Hes, Frederik J.; Mautner, Victor F.; Harder, Anja; Tinschert, Sigrid; Mundlos, Stefan; Kolanczyk, Mateusz

2015-01-01

Background Neurofibromatosis type I (NF1, MIM#162200) is a relatively frequent genetic condition, which predisposes to tumor formation. Apart from tumors, individuals with NF1 often exhibit endocrine abnormalities such as precocious puberty (2,5–5% of NF1 patients) and some cases of hypertension (16% of NF1 patients). Several cases of adrenal cortex adenomas have been described in NF1 individuals supporting the notion that neurofibromin might play a role in adrenal cortex homeostasis. However, no experimental data were available to prove this hypothesis. Materials and Methods We analysed Nf1Prx1 mice and one case of adrenal cortical hyperplasia in a NF1patient. Results In Nf1Prx1 mice Nf1 is inactivated in the developing limbs, head mesenchyme as well as in the adrenal gland cortex, but not the adrenal medulla or brain. We show that adrenal gland size is increased in NF1Prx1 mice. Nf1Prx1 female mice showed corticosterone and aldosterone overproduction. Molecular analysis of Nf1 deficient adrenals revealed deregulation of multiple proteins, including steroidogenic acute regulatory protein (StAR), a vital mitochondrial factor promoting transfer of cholesterol into steroid making mitochondria. This was associated with a marked upregulation of MAPK pathway and a female specific increase of cAMP concentration in murine adrenal lysates. Complementarily, we characterized a patient with neurofibromatosis type I with macronodular adrenal hyperplasia with ACTH-independent cortisol overproduction. Comparison of normal control tissue- and adrenal hyperplasia- derived genomic DNA revealed loss of heterozygosity (LOH) of the wild type NF1 allele, showing that biallelic NF1 gene inactivation occurred in the hyperplastic adrenal gland. Conclusions Our data suggest that biallelic loss of Nf1 induces autonomous adrenal hyper-activity. We conclude that Nf1 is involved in the regulation of adrenal cortex function in mice and humans. PMID:25775093

Reconstitution of the NF1 GAP-related domain in NF1-deficient human Schwann cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thomas, Stacey L.; Neuroscience Program, Loyola University Medical Center, Maywood, IL; Department of Anatomy and Cell Biology, University of Illinois Chicago, Chicago, IL

Schwann cells derived from peripheral nerve sheath tumors from individuals with Neurofibromatosis Type 1 (NF1) are deficient for the protein neurofibromin, which contains a GAP-related domain (NF1-GRD). Neurofibromin-deficient Schwann cells have increased Ras activation, increased proliferation in response to certain growth stimuli, increased angiogenic potential, and altered cell morphology. This study examined whether expression of functional NF1-GRD can reverse the transformed phenotype of neurofibromin-deficient Schwann cells from both benign and malignant peripheral nerve sheath tumors. We reconstituted the NF1-GRD using retroviral transduction and examined the effects on cell morphology, growth potential, and angiogenic potential. NF1-GRD reconstitution resulted in morphologic changes,more » a 16-33% reduction in Ras activation, and a 53% decrease in proliferation in neurofibromin-deficient Schwann cells. However, NF1-GRD reconstitution was not sufficient to decrease the in vitro angiogenic potential of the cells. This study demonstrates that reconstitution of the NF1-GRD can at least partially reverse the transformation of human NF1 tumor-derived Schwann cells.« less

Managed Retreat in New York after Sandy: Incentivizing Participation in High-Cost Areas

NASA Astrophysics Data System (ADS)

McDonnell, S.; Ghorbani, P.; Wolf, C.; Stovall, G.

2017-12-01

Extreme weather events may potentially displace millions of people worldwide by 2100 (Nicholls et al., 2011). In the US, flood-prone areas are still attractive to many residents (Dyckman, St. John, & London, 2014), and the most common policies such as zoning or subsidized flood insurance continue to incentivize more development (Mechler & Bouwer, 2015). An increasingly popular alternative for mitigating flood damage is managed retreat, which consists of buying out properties in hazardous areas and relocating the owners elsewhere. We explore New York State's buyout program—a $680 million program administered under its Community Development Block Grant-Disaster Recovery (CDBG-DR) allocation—in the aftermath of Superstorm Sandy. Buyouts in New York tend to be costlier because of higher housing prices and density (Lincoln Institute, 2016), and potential participants may face challenges finding comparable housing within their communities. Since buyout offers are based on property values, homeowners with lower net property values may have less incentive to participate. We ask what neighborhood, household, and property characteristics affect the likelihood of participating in the buyout program. Specifically, are lower property values a disincentive to participation? We use binomial and multinomial logistic regression analyses to estimate the likelihood of participation for a sample of 2,062 properties invited to the program. Our main predictor compares the net offer amount against the local median housing value, controlling for an array of household and neighborhood characteristics. We find that relative property values are inversely correlated with participation, more visibly pronounced in areas with larger gaps between applicants' property values and local home values. While CDBG-DR is specifically geared towards lower-income families and neighborhoods, our findings imply that its existing structure may hinder engagement of these target groups in high-cost areas

The outbreak of West Nile virus infection in the New York City area in 1999.

PubMed

Nash, D; Mostashari, F; Fine, A; Miller, J; O'Leary, D; Murray, K; Huang, A; Rosenberg, A; Greenberg, A; Sherman, M; Wong, S; Layton, M

2001-06-14

In late August 1999, an unusual cluster of cases of meningoencephalitis associated with muscle weakness was reported to the New York City Department of Health. The initial epidemiologic and environmental investigations suggested an arboviral cause. Active surveillance was implemented to identify patients hospitalized with viral encephalitis and meningitis. Cerebrospinal fluid, serum, and tissue specimens from patients with suspected cases underwent serologic and viral testing for evidence of arboviral infection. Outbreak surveillance identified 59 patients who were hospitalized with West Nile virus infection in the New York City area during August and September of 1999. The median age of these patients was 71 years (range, 5 to 95). The overall attack rate of clinical West Nile virus infection was at least 6.5 cases per million population, and it increased sharply with age. Most of the patients (63 percent) had clinical signs of encephalitis; seven patients died (12 percent). Muscle weakness was documented in 27 percent of the patients and flaccid paralysis in 10 percent; in all of the latter, nerve conduction studies indicated an axonal polyneuropathy in 14 percent. An age of 75 years or older was an independent risk factor for death (relative risk adjusted for the presence or absence of diabetes mellitus, 8.5; 95 percent confidence interval, 1.2 to 59.1), as was the presence of diabetes mellitus (age-adjusted relative risk, 5.1; 95 percent confidence interval, 1.5 to 17.3). This outbreak of West Nile meningoencephalitis in the New York City metropolitan area represents the first time this virus has been detected in the Western Hemisphere. Given the subsequent rapid spread of the virus, physicians along the eastern seaboard of the United States should consider West Nile virus infection in the differential diagnosis of encephalitis and viral meningitis during the summer months, especially in older patients and in those with muscle weakness.

Loss of neurofibromatosis type 1 (NF1) gene expression in pheochromocytomas from patients without NF1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geist, R.T.; Gutmann, D.H.; Moley, J.F.

The neurofibromatosis type 1 (NF1) gene encodes a tumor suppressor protein, termed neurofibromin. Loss of NF1 gene expression has been reported in Schwann cell tumors (neurofibrosarcomas) from patients with NF1 as well as malignant and neuroblastomas from patients without NF1. Previously, we demonstrated the lack of neurofibromin expression in six pheochromocytomas from patients with NF1, suggesting that neurofibromin loss is associated with the progression to neoplasia in pheochromocytomas in these patients. The lack of NF1 gene expression in NF1 patient pheochromocytomas supports the notion that neurofibromin might be an essential regulator of cell growth in these cells. To determine whethermore » NF1 gene expression is similarly altered in pheochromocytomas from patients without NF1, twenty pheochromocytomas were examined for the presence of NF1 RNA by reverse-transcribed PCR (RT-PCR). Lack of NF1 gene expression was documented in four of these twenty tumors (20%) which corresponds to previously reported numbers for malignant melanomas and neuroblastomas in non-NF1 patients. Of these twenty pheochromocytomas, one of four sporadic tumors, one of ten tumors from patients with MEN2A, one of four tumors from patients with MEN2B, and one of two tumors from patients with von Hippel-Lindau syndrome demonstrated loss of NF1 gene expression. In all cases, the quality and quantity of tumor RNA was determined by RT-PCR amplification using primers which amplify cyclophilin RNA. We previously demonstrated that these tumors do not harbor activating mutations of the N-ras, K-ras or H-ras proto-oncogenes. These results suggest that loss of NF1 gene expression is frequently associated with the progression to neoplasia in tumors derived from adrenal medullary tissue in patients without clinical manifestations of neurofibromatosis and supports the notion that neurofibromin is a tumor suppressor gene product involved in the pathogenesis of a wide variety of tumor types.« less

Reading the landscape: citywide social assessment of New York City parks and natural areas in 2013-2014

Treesearch

D.S. Novem Auyeung; Lindsay K. Campbell; Michelle Johnson; Nancy Falxa Sonti; Erika Svendsen

2016-01-01

In 2001, the New York City Department of Parks & Recreation (NYC Parks) Natural Resources Group created the Forever Wild Program to protect nearly 9,000 acres of forests, wetlands, and meadows citywide. Although these areas were set aside over a decade ago, we have little systematic evidence about how park visitors view, use, and value parks with these...

Quenching Rate Constants of NF(A1 Delta) by N2F4, NF3, NF(X), SiF4, HNCO and NCO at Room Temperature

DTIC Science & Technology

1993-01-01

F., ill; Helvajian . H .; Holloway. J. S.; Koffend, .3. J.1 base interaction between NF(aaA) and NF(X3Z-). Although the PAys. Chem. 1969, 93, 7818. 4...Since NF(a’&) possibly could be generated by the H + NF2 mis Metuho ieems reaction in practical laser devices. there is a need to know the reEimoM...and NF(b’Z+) are of a 30% CF4/Ar mixture together with additional A& tiahMb h • f also of practical interest. Since these reactions involve ground

Publication List - New York State Museum.

ERIC Educational Resources Information Center

New York State Museum, Albany.

Presented is a list of publications in six areas: (1) Anthropology and Archeology, (2) Botany, (3) Entomology, (4) Zoology, (5) Geology and Paleontology, and (6) Miscellaneous. This list was produced by the New York State Department of Education in cooperation with the New York State Museum. The list includes the publication number, author(s),…

The New York State Mentoring Program.

ERIC Educational Resources Information Center

Cuomo, Matilda R.

This conference address discusses New York State programs for children and families, focusing on a mentoring program. New York State has 44 rural counties, which comprise 80% of the state's total area. Rural schools face limited financial resources and access to services. Rural school children are more likely to face failure than urban or suburban…

Chemical contamination of soils in the New York City area following Hurricane Sandy.

PubMed

Mandigo, Amy C; DiScenza, Dana J; Keimowitz, Alison R; Fitzgerald, Neil

2016-10-01

This paper presents a unique data set of lead, arsenic, polychlorinated biphenyl (PCB), and polycyclic aromatic hydrocarbon (PAH) concentrations in soil samples collected from the metropolitan New York City area in the aftermath of Hurricane Sandy. Initial samples were collected by citizen scientists recruited via social media, a relatively unusual approach for a sample collection project. Participants in the affected areas collected 63 usable samples from basements, gardens, roads, and beaches. Results indicate high levels of arsenic, lead, PCBs, and PAHs in an area approximately 800 feet south of the United States Environmental Protection Agency (US EPA) Superfund site at Newtown Creek. A location adjacent to the Gowanus Canal, another Superfund site, was found to have high PCB concentrations. Areas of high PAH contamination tended to be near high traffic areas or next to sites of known contamination. While contamination as a direct result of Hurricane Sandy cannot be demonstrated conclusively, the presence of high levels of contamination close to known contamination sites, evidence for co-contamination, and decrease in number of samples containing measureable amounts of semi-volatile compounds from samples collected at similar locations 9 months after the storm suggest that contaminated particles may have migrated to residential areas as a result of flooding.

76 FR 56860 - New York Disaster Number NY-00109

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-14

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12778 and 12779] New York Disaster Number NY... the Presidential declaration of a major disaster for Public Assistance Only for the State of New York... the State of NEW YORK, dated 08/31/2011, is hereby amended to include the following areas as adversely...

76 FR 68804 - New York Disaster Number NY-00113

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-07

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12858 and 12859] New York Disaster Number NY... the Presidential declaration of a major disaster for Public Assistance Only for the State of New York... the State of New York, dated 09/23/2011, is hereby amended to include the following areas as adversely...

76 FR 62131 - New York Disaster Number NY-00113

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-06

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12858 and 12859] New York Disaster Number NY... the Presidential declaration of a major disaster for Public Assistance only for the State of New York... the State of New York, dated 09/23/2011, is hereby amended to include the following areas as adversely...

78 FR 47816 - New York Disaster Number NY-00136

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-06

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13667 and 13668] New York Disaster Number NY... the Presidential declaration of a major disaster for Public Assistance Only for the State of New York... the State of NEW YORK, dated 07/12/2013, is hereby amended to include the following areas as adversely...

76 FR 64420 - New York Disaster Number NY-00113

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-18

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12858 and 12859] New York Disaster Number NY... the Presidential declaration of a major disaster for Public Assistance Only for the State of New York... the State of New York, dated 09/23/2011, is hereby amended to include the following areas as adversely...

76 FR 67245 - New York Disaster Number NY-00113

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-31

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12858 and 12859] New York Disaster Number NY... the Presidential declaration of a major disaster for Public Assistance Only for the State of New York... the State of New York, dated 09/23/2011, is hereby amended to include the following areas as adversely...

76 FR 63699 - New York Disaster Number NY-00113

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-13

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12858 and 12859] New York Disaster Number NY... the Presidential declaration of a major disaster for Public Assistance Only for the State of New York... the State of New York, dated 09/23/2011, is hereby amended to include the following areas as adversely...

76 FR 66111 - New York Disaster Number NY-00113

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-25

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12858 and 12859] New York Disaster Number NY... the Presidential declaration of a major disaster for Public Assistance Only for the State of New York... the State of New York, dated 09/23/2011, is hereby amended to include the following areas as adversely...

75 FR 41558 - New York Disaster Number NY-00089

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-16

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12123 and 12124] New York Disaster Number NY... the Presidential declaration of a major disaster for Public Assistance Only for the State of New York... the State of New York, dated 04/16/2010, is hereby amended to include the following areas as adversely...

75 FR 29471 - The New York North Shore Helicopter Route

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-26

...-0302; Notice No. 10-08] RIN 2120-AJ75 The New York North Shore Helicopter Route AGENCY: Federal... action would require helicopter operators to use the New York North Shore Route when operating in that area of Long Island, New York. The North Shore Route was added to the New York Helicopter Route [[Page...

77 FR 69915 - New York Disaster Number NY-00130

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-21

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13365 and 13366] New York Disaster Number NY... the Presidential declaration of a major disaster for the State of New York (FEMA-4085-DR), dated 10/30... State of NEW YORK, dated 10/30/2012 is hereby amended to include the following areas as adversely...

77 FR 68195 - New York Disaster Number NY-00130

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-15

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13365 and 13366] New York Disaster Number NY... the Presidential declaration of a major disaster for the State of New York (FEMA-4085-DR), dated 10/30... State of NEW YORK, dated 10/30/2012 is hereby amended to include the following areas as adversely...

76 FR 18289 - New York Disaster Number NY-00102

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-01

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12479 and 12480] New York Disaster Number NY... the Presidential declaration of a major disaster for Public Assistance Only for the State of New York... organizations in the State of New York, dated 02/18/2011, is hereby amended to include the following areas as...

76 FR 56856 - New York Disaster Number NY-00108

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-14

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12776 and 12777] New York Disaster Number NY... the Presidential declaration of a major disaster for the State of New York (FEMA-4020-DR), dated 08/31... State of New York, dated 08/31/2011 is hereby amended to include the following areas as adversely...

76 FR 60512 - New York; Emergency and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-29

.... FEMA-3328-EM; Docket ID FEMA-2011-0001] New York; Emergency and Related Determinations AGENCY: Federal... of an emergency for the State of New York (FEMA-3328-EM), dated August 26, 2011, and related...: I have determined that the emergency conditions in certain areas of the State of New York resulting...

76 FR 61727 - New York; Emergency and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-05

.... FEMA-3341-EM; Docket ID FEMA-2011-0001] New York; Emergency and Related Determinations AGENCY: Federal... of an emergency for the State of New York (FEMA-3341-EM), dated September 8, 2011, and related...: I have determined that the emergency conditions in certain areas of the State of New York resulting...

76 FR 56857 - New York Disaster Number NY-00108

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-14

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12776 and 12777] New York Disaster Number NY... the Presidential declaration of a major disaster for the State of New York (FEMA-4020-DR), dated08/31... State of New York, dated 08/31/2011 is hereby amended to include the following areas as adversely...

76 FR 13698 - New York Disaster Number NY-00102

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-14

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12479 and 12480] New York Disaster Number NY... the Presidential declaration of a major disaster for Public Assistance Only for the State of New York... organizations in the State of New York, dated 02/18/2011, is hereby amended to include the following areas as...

Tunable UV Laser Photolysis of NF2: Quantum Yield for NF(a1 delta) Production.

DTIC Science & Technology

1988-05-25

UV Laser Photolysis of NF2: Quantum Yield for NF(a A) Production ’v0 LR. F. HEIDNER, H . HELVAJIAN , 4and J. B. KOFFEND Aerophysics Laboratory...experiments, the chemistry of NF2 with various hydrocarbons has been studied. It has also been shown that the addition-elimination reaction between H and NF2...COMPLI R LEN SP, 3 ,HAND L BE AM~ H O [ I , , i 1 CAIHOC IAM COOLED GaAs CAPACITANCE PHOTOTUIBE MANOMETER _ LENS /’~ ~L + . ANMEE _.... BANDPASS FILTER

76 FR 59766 - New York Disaster Number NY-00110

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-27

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12824 and 12825] New York Disaster Number NY... the Presidential declaration of a major disaster for the State of New York (FEMA-4031-DR), dated 09/13... declaration for the State of New York, dated 09/13/2011 is hereby amended to include the following areas as...

76 FR 59178 - New York Disaster Number NY-00108

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-23

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12776 and 12777] New York Disaster Number NY... the Presidential declaration of a major disaster for the State of New York (FEMA-4020-DR), dated 08/31... declaration for the State of New York, dated 08/31/2011 is hereby amended to include the following areas as...

76 FR 58328 - New York Disaster Number NY-00108

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-20

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12776 and 12777] New York Disaster Number NY... the Presidential declaration of a major disaster for the State of New York (FEMA-4020-DR), dated 08/31... declaration for the State of New York, dated 08/31/2011 is hereby amended to include the following areas as...

76 FR 58329 - New York Disaster Number NY-00108

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-20

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12776 and 12777] New York Disaster Number NY... the Presidential declaration of a major disaster for the State of New York (FEMA-4020-DR), dated 08/31... declaration for the State of NEW YORK, dated 08/31/2011, is hereby amended to include the following areas as...

Geohydrology of the valley-fill aquifer in the Bath area, Lower Cohocton River, Steuben County, New York

USGS Publications Warehouse

Pagano, Timothy S.; Terry, D.B.; Shaw, M.L.; Ingram, A.W.

1984-01-01

The Bath valley-fill aquifer, southern New York, composed of outwash, ice-contact, and ice-disintegration sand and gravel, is highly productive and is in many areas in hydraulic contact with the Cohocton River. Potential well yields range 50 to more than 1,000 gallons per minute. Most of the aquifer is under shallow water-table conditions and vulnerable to surface contamination. Thickness ranges from 20 to 40 feet. Buried aquifers are present locally. The aquifer system underlies an area containing only a few small communities and therefore is not heavily pumped. Geohydrologic data are compiled on six maps at 1:24,000 scale and on a sheet of geologic sections. The maps depict surficial geology, soil-infiltration capacity, potentiometric surface, aquifer thickness, well yields, and land use. This map report set is one in a series of four that depict selected aquifers in Wester New York. It supplements a series that is being done by the U.S. Geological Survey in cooperation with State agencies. The maps are based largely on published reports, data filled in several State agencies, and some additional field data collection. (USGS)

48 CFR 611.002 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Policy. 611.002 Section 611.002 Federal Acquisition Regulations System DEPARTMENT OF STATE COMPETITION AND ACQUISITION PLANNING DESCRIBING AGENCY NEEDS 611.002 Policy. ...

Divergent Effects of Arsenic on NF-κB Signaling in Different Cells or Tissues: A Systematic Review and Meta-Analysis.

PubMed

Wei, Meng; Liu, Jiaming; Xu, Mengchuan; Rui, Dongsheng; Xu, Shangzhi; Feng, Gangling; Ding, Yusong; Li, Shugang; Guo, Shuxia

2016-01-26

Arsenic is ubiquitously present in human lives, including in the environment and organisms, and has divergent effects between different cells and tissues and between different exposure times and doses. These observed effects have been attributed to the nuclear transcription factor kappa B(NF-κB) signaling pathway. Herein, a meta-analysis was performed by independently searching databases including the Cochrane Library, PubMed, Springer, Embase, and China National Knowledge Infrastructure, to analyze effects of arsenic exposure on NF-κB signaling. Compared to controls, in the exposed group, p-IκB levels were found to be 8.13-fold higher (95% CI, 2.40-13.85; Z = 2.78; p = 0.005), IκB levels were 16.19-fold lower (95% CI, -27.44--4.94; Z = 2.78; p = 0.005), and NF-κBp65 levels were 0.77-fold higher (95% CI, 0.13-1.42; Z = 2.34; p = 0.02) for normal cells and tissue, while NF-κBp65 levels were 4.90-fold lower (95% CI, -8.49-1.31; Z = 2.62; p = 0.009), NF-κB activity was 2.45-fold lower (95% CI, -3.66-1.25; Z = 4.00; p < 0.0001), and DNA-binding activity of NF-κB was 9.75-fold lower (95% CI, -18.66-4.54; Z = 2.15; p = 0.03) for abnormal cells and tissue. Short exposure to high arsenic doses activated the NF-κB signaling pathway, while long exposure to low arsenic doses suppressed NF-κB signaling pathway activation. These findings may provide a theoretical basis for injurious and therapeutic mechanisms of divergent effects of arsenic.

The Neurofibromatoses. Part 1: NF1.

PubMed

Lu-Emerson, Christine; Plotkin, Scott R

2009-01-01

The neurofibromatoses, including neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), and schwannomatosis, comprise a group of genetically distinct disorders of the nervous system unified by the predisposition to nerve sheath tumors. NF1 is the most common neurogenetic disorder, with a birth incidence of 1 in 3000. NF1 is inherited in auto-somal dominant fashion with full penetrance and variable expressivity. The hallmark lesion of NF1 is the neurofibroma, a benign tumor derived from the nerve sheath and composed of a mixture of proliferating Schwann cells, fibroblasts, mast cells, and pericytes. Other findings include gliomas, learning disability, vasculopathy, and bony abnormalities. Café au lait macules are typically the initial clinical manifestation of NF1 and tend to increase in size and number throughout childhood and puberty. Current treatment of patients with NF1 remains primarily surgical. Genetic counseling is essential for adult patients because molecular diagnostic testing can minimize the risk of transmission to children.

Civil Tiltrotor Feasibility Study for the New York and Washington Terminal Areas

NASA Technical Reports Server (NTRS)

Stouffer, Virginia; Johnson, Jesse; Gribko, Joana; Yackovetsky, Robert (Technical Monitor)

2001-01-01

NASA tasked LMI to assess the potential contributions of a yet-undeveloped Civil Tiltrotor aircraft (CTR) in improving capacity in the National Airspace System in all weather conditions. The CTRs studied have assumed operating parameters beyond current CTR capabilities. LMI analyzed CTRs three ways: in fast-time terminal area modeling simulations of New York and Washington to determine delay and throughput impacts; in the Integrated Noise Model, to determine local environmental impact; and with an economic model, to determine the price viability of a CTR. The fast-time models encompassed a 250 nmi range and included traffic interactions from local airports. Both the fast-time simulation and the noise model assessed impacts from traffic levels projected for 1999, 2007, and 2017. Results: CTRs can reduce terminal area delays due to concrete congestion in all time frames. The maximum effect, the ratio of CTRs to jets and turboprop aircraft at a subject airport should be optimized. The economic model considered US traffic only and forecasted CTR sales beginning in 2010.

Segmental NF: A Guide for Patients

MedlinePlus

... for those in whom a diagnosis of segmental neurofibromatosis (NF) has been made or is being considered. ... have a child affected with NF. What is Neurofibromatosis (NF)? You may have heard of two different ...

76 FR 2195 - Open Meeting of the Area 1 Taxpayer Advocacy Panel (Including the States of New York, New Jersey...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-12

... DEPARTMENT OF THE TREASURY Internal Revenue Service Open Meeting of the Area 1 Taxpayer Advocacy Panel (Including the States of New York, New Jersey, Connecticut, Massachusetts, Rhode Island, New Hampshire, Vermont and Maine) AGENCY: Internal Revenue Service (IRS) Treasury. ACTION: Notice of meeting...

76 FR 32022 - Open Meeting of the Area 1 Taxpayer Advocacy Panel (Including the States of New York, New Jersey...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-02

... DEPARTMENT OF THE TREASURY Internal Revenue Service Open Meeting of the Area 1 Taxpayer Advocacy Panel (Including the States of New York, New Jersey, Connecticut, Massachusetts, Rhode Island, New Hampshire, Vermont and Maine) AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice of Meeting...

48 CFR 5.002 - Policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Policy. 5.002 Section 5.002 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING PUBLICIZING CONTRACT ACTIONS 5.002 Policy. Contracting officers must publicize contract actions in order to...

48 CFR 5.002 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Policy. 5.002 Section 5.002 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING PUBLICIZING CONTRACT ACTIONS 5.002 Policy. Contracting officers must publicize contract actions in order to...

48 CFR 410.002 - Procedures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Procedures. 410.002 Section 410.002 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE COMPETITION AND ACQUISITION PLANNING MARKET RESEARCH 410.002 Procedures. Market research must include obtaining information on...

48 CFR 410.002 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Procedures. 410.002 Section 410.002 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE COMPETITION AND ACQUISITION PLANNING MARKET RESEARCH 410.002 Procedures. Market research must include obtaining information on...

[NF-κB signaling pathways and the future perspectives of bone disease therapy using selective inhibitors of NF-κB].

PubMed

Jimi, Eijiro; Fukushima, Hidefumi

2016-02-01

The transcriptional factor nuclear factor κB(NF-κB)regulates the expression of a wide variety of genes that are involved in immune and inflammatory responses, proliferation, and tumorigenesis. NF-κB consists of five members, such as p65(RelA), RelB, c-Rel, p50/p105(NF-κB1), and p52/p100(NF-κB2). There are two distinct NF-κB activation pathways, termed the classical and alternative NF-κB signaling pathways. Since mice lacking both p50 and p52 subunits developed typical osteopetrosis, due to total lack of osteoclasts, NF-κB is also important osteoclast differentiation. A selective NF-κB inhibitor blocked receptor activator of NF-κB ligand(RANKL)-induced osteoclastogenesis both in vitro and in vivo. Recent findings have shown that inactivation of NF-κB enhances osteoblast differentiation in vitro and bone formation in vivo. NF-κB is constitutively activated in many cancers including oral squamous cell carcinoma(OSCC), and is involved in the invasive characteristics of OSCC. A selective NF-κB inhibitor also prevented jaw bone destruction by OSCC by reduced osteoclast numbers in animal model. Thus the inhibition of NF-κB might useful for the treatment of bone diseases, such as arthritis, osteoporosis, periodontitis, and bone invasion by OSCC by inhibiting bone resorption and by stimulating bone formation.

48 CFR 2834.002 - Policy.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Policy. 2834.002 Section 2834.002 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE SPECIAL CATEGORIES OF CONTRACTING MAJOR SYSTEM ACQUISITION General 2834.002 Policy. In accordance with Pub. L. 98-577, the Small Business...

48 CFR 2834.002 - Policy.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Policy. 2834.002 Section 2834.002 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE SPECIAL CATEGORIES OF CONTRACTING MAJOR SYSTEM ACQUISITION General 2834.002 Policy. In accordance with Pub. L. 98-577, the Small Business...

EVM005: an ectromelia-encoded protein with dual roles in NF-κB inhibition and virulence.

PubMed

van Buuren, Nicholas; Burles, Kristin; Schriewer, Jill; Mehta, Ninad; Parker, Scott; Buller, R Mark; Barry, Michele

2014-08-01

Poxviruses contain large dsDNA genomes encoding numerous open reading frames that manipulate cellular signalling pathways and interfere with the host immune response. The NF-κB signalling cascade is an important mediator of innate immunity and inflammation, and is tightly regulated by ubiquitination at several key points. A critical step in NF-κB activation is the ubiquitination and degradation of the inhibitor of kappaB (IκBα), by the cellular SCFβ-TRCP ubiquitin ligase complex. We show here that upon stimulation with TNFα or IL-1β, Orthopoxvirus-infected cells displayed an accumulation of phosphorylated IκBα, indicating that NF-κB activation was inhibited during poxvirus infection. Ectromelia virus is the causative agent of lethal mousepox, a natural disease that is fatal in mice. Previously, we identified a family of four ectromelia virus genes (EVM002, EVM005, EVM154 and EVM165) that contain N-terminal ankyrin repeats and C-terminal F-box domains that interact with the cellular SCF ubiquitin ligase complex. Since degradation of IκBα is catalyzed by the SCFβ-TRCP ubiquitin ligase, we investigated the role of the ectromelia virus ankyrin/F-box protein, EVM005, in the regulation of NF-κB. Expression of Flag-EVM005 inhibited both TNFα- and IL-1β-stimulated IκBα degradation and p65 nuclear translocation. Inhibition of the NF-κB pathway by EVM005 was dependent on the F-box domain, and interaction with the SCF complex. Additionally, ectromelia virus devoid of EVM005 was shown to inhibit NF-κB activation, despite lacking the EVM005 open reading frame. Finally, ectromelia virus devoid of EVM005 was attenuated in both A/NCR and C57BL/6 mouse models, indicating that EVM005 is required for virulence and immune regulation in vivo.

EVM005: An Ectromelia-Encoded Protein with Dual Roles in NF-κB Inhibition and Virulence

PubMed Central

Schriewer, Jill; Mehta, Ninad; Parker, Scott; Buller, R. Mark; Barry, Michele

2014-01-01

Poxviruses contain large dsDNA genomes encoding numerous open reading frames that manipulate cellular signalling pathways and interfere with the host immune response. The NF-κB signalling cascade is an important mediator of innate immunity and inflammation, and is tightly regulated by ubiquitination at several key points. A critical step in NF-κB activation is the ubiquitination and degradation of the inhibitor of kappaB (IκBα), by the cellular SCFβ-TRCP ubiquitin ligase complex. We show here that upon stimulation with TNFα or IL-1β, Orthopoxvirus-infected cells displayed an accumulation of phosphorylated IκBα, indicating that NF-κB activation was inhibited during poxvirus infection. Ectromelia virus is the causative agent of lethal mousepox, a natural disease that is fatal in mice. Previously, we identified a family of four ectromelia virus genes (EVM002, EVM005, EVM154 and EVM165) that contain N-terminal ankyrin repeats and C-terminal F-box domains that interact with the cellular SCF ubiquitin ligase complex. Since degradation of IκBα is catalyzed by the SCFβ-TRCP ubiquitin ligase, we investigated the role of the ectromelia virus ankyrin/F-box protein, EVM005, in the regulation of NF-κB. Expression of Flag-EVM005 inhibited both TNFα- and IL-1β-stimulated IκBα degradation and p65 nuclear translocation. Inhibition of the NF-κB pathway by EVM005 was dependent on the F-box domain, and interaction with the SCF complex. Additionally, ectromelia virus devoid of EVM005 was shown to inhibit NF-κB activation, despite lacking the EVM005 open reading frame. Finally, ectromelia virus devoid of EVM005 was attenuated in both A/NCR and C57BL/6 mouse models, indicating that EVM005 is required for virulence and immune regulation in vivo. PMID:25122471

NF-κB in Hematological Malignancies

PubMed Central

Imbert, Véronique; Peyron, Jean-François

2017-01-01

NF-κB (Nuclear Factor Κ-light-chain-enhancer of activated B cells) transcription factors are critical regulators of immunity, stress response, apoptosis, and differentiation. Molecular defects promoting the constitutive activation of canonical and non-canonical NF-κB signaling pathways contribute to many diseases, including cancer, diabetes, chronic inflammation, and autoimmunity. In the present review, we focus our attention on the mechanisms of NF-κB deregulation in hematological malignancies. Key positive regulators of NF-κB signaling can act as oncogenes that are often prone to chromosomal translocation, amplifications, or activating mutations. Negative regulators of NF-κB have tumor suppressor functions, and are frequently inactivated either by genomic deletions or point mutations. NF-κB activation in tumoral cells is also driven by the microenvironment or chronic signaling that does not rely on genetic alterations. PMID:28561798

Building Business Awareness in Rural New York.

ERIC Educational Resources Information Center

Stevens, Jean; Drake, Robert; Huber, Candace; Powers, Betty; Reuland, Kris

Half of New York State's 50 school-to-work (STW) programs are in rural areas. Following background on the development of New York's STW initiative, this paper describes four programs that are overcoming rural barriers to building an STW system. The GLOW Partnership addressed a primary concern of business partners: over-saturation of the limited…

20. SITE BUILDING 002 SCANNER BUILDING IN COMPUTER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. SITE BUILDING 002 - SCANNER BUILDING - IN COMPUTER ROOM LOOKING AT "CONSOLIDATED MAINTENANCE OPERATIONS CENTER" JOB AREA AND OPERATION WORK CENTER. TASKS INCLUDE RADAR MAINTENANCE, COMPUTER MAINTENANCE, CYBER COMPUTER MAINTENANCE AND RELATED ACTIVITIES. - Cape Cod Air Station, Technical Facility-Scanner Building & Power Plant, Massachusetts Military Reservation, Sandwich, Barnstable County, MA

An exploratory analysis of coping schemes used by paddlers who camped in the St. Regis Canoe Area, New York

Treesearch

Blake M. Probst; Rudy M. Schuster; Chad P. Dawson

2009-01-01

This study addresses requirements in the Adirondack Park State Land Master Plan for developing unit management plans. Recreational paddlers in New York State's St. Regis Canoe Area were surveyed about their perceptions of stress from daily hassles common to outdoor recreation activities, their coping responses to hassles, daily visit satisfaction, and overall trip...

New York, New York

ERIC Educational Resources Information Center

Santos, Thomas W.

2008-01-01

This article describes New York City. It presents information about its history, immigration process, geography, architecture, rivers, bridges, famous buildings and parks, famous neighborhoods, arts and entertainment, and tourist attractions and activities. The article also provides useful websites about New York City. It ends with a text about…

STS-135 New York City Visit

NASA Image and Video Library

2011-08-17

New York Mayor Michael Bloomberg, center, talks about the construction around the site where the World Trade Center once stood to NASA Deputy Administrator Lori Garver, right, and members of the STS-135 crew including commander Chris Ferguson, left, mission specialist Rex Walheim, second right, and pilot Doug Hurley, rear, as they tour the area, Wednesday evening, Aug. 18, 2011, in New York. Photo Credit: (NASA/Paul E. Alers)

77 FR 69647 - New York; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-20

.... FEMA-4085-DR; Docket ID FEMA-2012-0002] New York; Major Disaster and Related Determinations AGENCY... declaration of a major disaster for the State of New York (FEMA-4085-DR), dated October 30, 2012, and related... have determined that the damage in certain areas of the State of New York resulting from Hurricane...

33 CFR 110.60 - Captain of the Port, New York.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Captain of the Port, New York... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.60 Captain of the Port, New York. (a) Western... point of origin. (d) New York Harbor. (1) Newark Bay, Southeast. All waters bound by the following...

76 FR 61731 - New York; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-05

.... FEMA-4020-DR; Docket ID FEMA-2011-0001] New York; Major Disaster and Related Determinations AGENCY... declaration of a major disaster for the State of New York (FEMA-4020-DR), dated August 31, 2011, and related... have determined that the damage in certain areas of the State of New York resulting from Hurricane...

33 CFR 161.25 - Vessel Traffic Service New York Area.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Raritan Bay to the Raritan River Rail Road Bridge; and then north including the waters of the Arthur Kill... waters of the Kill Van Kull and Upper New York Bay north to a line drawn east-west from the Holland...

33 CFR 161.25 - Vessel Traffic Service New York Area.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Raritan Bay to the Raritan River Rail Road Bridge; and then north including the waters of the Arthur Kill... waters of the Kill Van Kull and Upper New York Bay north to a line drawn east-west from the Holland...

33 CFR 161.25 - Vessel Traffic Service New York Area.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Raritan Bay to the Raritan River Rail Road Bridge; and then north including the waters of the Arthur Kill... waters of the Kill Van Kull and Upper New York Bay north to a line drawn east-west from the Holland...

33 CFR 161.25 - Vessel Traffic Service New York Area.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Raritan Bay to the Raritan River Rail Road Bridge; and then north including the waters of the Arthur Kill... waters of the Kill Van Kull and Upper New York Bay north to a line drawn east-west from the Holland...

Small-area estimation of the probability of toxocariasis in New York City based on sociodemographic neighborhood composition.

PubMed

Walsh, Michael G; Haseeb, M A

2014-01-01

Toxocariasis is increasingly recognized as an important neglected infection of poverty (NIP) in developed countries, and may constitute the most important NIP in the United States (US) given its association with chronic sequelae such as asthma and poor cognitive development. Its potential public health burden notwithstanding, toxocariasis surveillance is minimal throughout the US and so the true burden of disease remains uncertain in many areas. The Third National Health and Nutrition Examination Survey conducted a representative serologic survey of toxocariasis to estimate the prevalence of infection in diverse US subpopulations across different regions of the country. Using the NHANES III surveillance data, the current study applied the predicted probabilities of toxocariasis to the sociodemographic composition of New York census tracts to estimate the local probability of infection across the city. The predicted probability of toxocariasis ranged from 6% among US-born Latino women with a university education to 57% among immigrant men with less than a high school education. The predicted probability of toxocariasis exhibited marked spatial variation across the city, with particularly high infection probabilities in large sections of Queens, and smaller, more concentrated areas of Brooklyn and northern Manhattan. This investigation is the first attempt at small-area estimation of the probability surface of toxocariasis in a major US city. While this study does not define toxocariasis risk directly, it does provide a much needed tool to aid the development of toxocariasis surveillance in New York City.

Small-Area Estimation of the Probability of Toxocariasis in New York City Based on Sociodemographic Neighborhood Composition

PubMed Central

Walsh, Michael G.; Haseeb, M. A.

2014-01-01

Toxocariasis is increasingly recognized as an important neglected infection of poverty (NIP) in developed countries, and may constitute the most important NIP in the United States (US) given its association with chronic sequelae such as asthma and poor cognitive development. Its potential public health burden notwithstanding, toxocariasis surveillance is minimal throughout the US and so the true burden of disease remains uncertain in many areas. The Third National Health and Nutrition Examination Survey conducted a representative serologic survey of toxocariasis to estimate the prevalence of infection in diverse US subpopulations across different regions of the country. Using the NHANES III surveillance data, the current study applied the predicted probabilities of toxocariasis to the sociodemographic composition of New York census tracts to estimate the local probability of infection across the city. The predicted probability of toxocariasis ranged from 6% among US-born Latino women with a university education to 57% among immigrant men with less than a high school education. The predicted probability of toxocariasis exhibited marked spatial variation across the city, with particularly high infection probabilities in large sections of Queens, and smaller, more concentrated areas of Brooklyn and northern Manhattan. This investigation is the first attempt at small-area estimation of the probability surface of toxocariasis in a major US city. While this study does not define toxocariasis risk directly, it does provide a much needed tool to aid the development of toxocariasis surveillance in New York City. PMID:24918785

Cornell University remote sensing program. [New York

NASA Technical Reports Server (NTRS)

Liang, T.; Mcnair, A. J.; Philipson, W. R. (Principal Investigator)

1978-01-01

The author has identified the following significant results. Available aerial photographs were used to characterize mosquito breeding sites in Oswego County, New York. Numerous wetlands are contained within this county; this area is the only inland area in North America to have confirmed outbreaks of eastern equine encephalitis. This photocharacterization of primary mosquito breeding sites will be used to develop effective spraying. Large scale color and color infrared aerial photographs were used to assess changes in aquatic vegetation that accompanied phosphorus reduction in an eutrophic lake in New York.

Current whole-body MRI applications in the neurofibromatoses: NF1, NF2, and schwannomatosis.

PubMed

Ahlawat, Shivani; Fayad, Laura M; Khan, Muhammad Shayan; Bredella, Miriam A; Harris, Gordon J; Evans, D Gareth; Farschtschi, Said; Jacobs, Michael A; Chhabra, Avneesh; Salamon, Johannes M; Wenzel, Ralph; Mautner, Victor F; Dombi, Eva; Cai, Wenli; Plotkin, Scott R; Blakeley, Jaishri O

2016-08-16

The Response Evaluation in Neurofibromatosis and Schwannomatosis (REiNS) International Collaboration Whole-Body MRI (WB-MRI) Working Group reviewed the existing literature on WB-MRI, an emerging technology for assessing disease in patients with neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis (SWN), to recommend optimal image acquisition and analysis methods to enable WB-MRI as an endpoint in NF clinical trials. A systematic process was used to review all published data about WB-MRI in NF syndromes to assess diagnostic accuracy, feasibility and reproducibility, and data about specific techniques for assessment of tumor burden, characterization of neoplasms, and response to therapy. WB-MRI at 1.5T or 3.0T is feasible for image acquisition. Short tau inversion recovery (STIR) sequence is used in all investigations to date, suggesting consensus about the utility of this sequence for detection of WB tumor burden in people with NF. There are insufficient data to support a consensus statement about the optimal imaging planes (axial vs coronal) or 2D vs 3D approaches. Functional imaging, although used in some NF studies, has not been systematically applied or evaluated. There are no comparative studies between regional vs WB-MRI or evaluations of WB-MRI reproducibility. WB-MRI is feasible for identifying tumors using both 1.5T and 3.0T systems. The STIR sequence is a core sequence. Additional investigation is needed to define the optimal approach for volumetric analysis, the reproducibility of WB-MRI in NF, and the diagnostic performance of WB-MRI vs regional MRI. © 2016 American Academy of Neurology.

Overexpression of NF90-NF45 Represses Myogenic MicroRNA Biogenesis, Resulting in Development of Skeletal Muscle Atrophy and Centronuclear Muscle Fibers

PubMed Central

Todaka, Hiroshi; Higuchi, Takuma; Yagyu, Ken-ichi; Sugiyama, Yasunori; Yamaguchi, Fumika; Morisawa, Keiko; Ono, Masafumi; Fukushima, Atsuki; Tsuda, Masayuki; Taniguchi, Taketoshi

2015-01-01

MicroRNAs (miRNAs) are involved in the progression and suppression of various diseases through translational inhibition of target mRNAs. Therefore, the alteration of miRNA biogenesis induces several diseases. The nuclear factor 90 (NF90)-NF45 complex is known as a negative regulator in miRNA biogenesis. Here, we showed that NF90-NF45 double-transgenic (dbTg) mice develop skeletal muscle atrophy and centronuclear muscle fibers in adulthood. Subsequently, we found that the levels of myogenic miRNAs, including miRNA 133a (miR-133a), which promote muscle maturation, were significantly decreased in the skeletal muscle of NF90-NF45 dbTg mice compared with those in wild-type mice. However, levels of primary transcripts of the miRNAs (pri-miRNAs) were clearly elevated in NF90-NF45 dbTg mice. This result indicated that the NF90-NF45 complex suppressed miRNA production through inhibition of pri-miRNA processing. This finding was supported by the fact that processing of pri-miRNA 133a-1 (pri-miR-133a-1) was inhibited via binding of NF90-NF45 to the pri-miRNA. Finally, the level of dynamin 2, a causative gene of centronuclear myopathy and concomitantly a target of miR-133a, was elevated in the skeletal muscle of NF90-NF45 dbTg mice. Taken together, we conclude that the NF90-NF45 complex induces centronuclear myopathy through increased dynamin 2 expression by an NF90-NF45-induced reduction of miR-133a expression in vivo. PMID:25918244

76 FR 44347 - New York; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-25

.... FEMA-1993-DR; Docket ID FEMA-2011-0001] New York; Major Disaster and Related Determinations AGENCY... declaration of a major disaster for the State of New York (FEMA-1993-DR), dated June 10, 2011, and related... determined that the damage in certain areas of the State of New York resulting from severe storms, flooding...

75 FR 65501 - New York; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-25

.... FEMA-1943-DR; Docket ID FEMA-2010-0002] New York; Major Disaster and Related Determinations AGENCY... declaration of a major disaster for the State of New York (FEMA-1943-DR), dated October 14, 2010, and related... have determined that the damage in certain areas of the State of New York resulting from severe storms...

78 FR 27414 - New York; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-10

.... FEMA-4111-DR; Docket ID FEMA-2013-0001] New York; Major Disaster and Related Determinations AGENCY... declaration of a major disaster for the State of New York (FEMA-4111-DR), dated April 23, 2013, and related... Act''), as follows: I have determined that the damage in certain areas of the State of New York...

76 FR 12362 - New York; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-07

.... FEMA-1957-DR; Docket ID FEMA-2011-0001] New York; Major Disaster and Related Determinations AGENCY... declaration of a major disaster for the State of New York (FEMA-1957-DR), dated February 18, 2011, and related... Act''), as follows :I have determined that the damage in certain areas of the State of New York...

78 FR 45549 - New York; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-29

.... FEMA-4129-DR; Docket ID FEMA-2013-0001] New York; Major Disaster and Related Determinations AGENCY... declaration of a major disaster for the State of New York (FEMA-4129-DR), dated July 12, 2013, and related... determined that the damage in certain areas of the State of New York resulting from severe storms and...

75 FR 22610 - New York; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-29

.... FEMA-1899-DR; Docket ID FEMA-2010-0002] New York; Major Disaster and Related Determinations AGENCY... declaration of a major disaster for the State of New York (FEMA-1899-DR), dated April 16, 2010, and related... in certain areas of the State of New York resulting from severe storms and flooding during the period...

46 CFR 163.002-15 - Performance.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 6 2012-10-01 2012-10-01 false Performance. 163.002-15 Section 163.002-15 Shipping...: SPECIFICATIONS AND APPROVAL CONSTRUCTION Pilot Hoist § 163.002-15 Performance. (a) Each pilot hoist must have sufficient performance capability to pass the approval tests in § 163.002-21. (b) [Reserved] ...

46 CFR 163.002-15 - Performance.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 6 2013-10-01 2013-10-01 false Performance. 163.002-15 Section 163.002-15 Shipping...: SPECIFICATIONS AND APPROVAL CONSTRUCTION Pilot Hoist § 163.002-15 Performance. (a) Each pilot hoist must have sufficient performance capability to pass the approval tests in § 163.002-21. (b) [Reserved] ...

46 CFR 163.002-15 - Performance.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 6 2011-10-01 2011-10-01 false Performance. 163.002-15 Section 163.002-15 Shipping...: SPECIFICATIONS AND APPROVAL CONSTRUCTION Pilot Hoist § 163.002-15 Performance. (a) Each pilot hoist must have sufficient performance capability to pass the approval tests in § 163.002-21. (b) [Reserved] ...

46 CFR 163.002-15 - Performance.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 6 2014-10-01 2014-10-01 false Performance. 163.002-15 Section 163.002-15 Shipping...: SPECIFICATIONS AND APPROVAL CONSTRUCTION Pilot Hoist § 163.002-15 Performance. (a) Each pilot hoist must have sufficient performance capability to pass the approval tests in § 163.002-21. (b) [Reserved] ...

46 CFR 163.002-15 - Performance.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 6 2010-10-01 2010-10-01 false Performance. 163.002-15 Section 163.002-15 Shipping...: SPECIFICATIONS AND APPROVAL CONSTRUCTION Pilot Hoist § 163.002-15 Performance. (a) Each pilot hoist must have sufficient performance capability to pass the approval tests in § 163.002-21. (b) [Reserved] ...

The C-terminal domains of NF-H and NF-M subunits maintain axonal neurofilament content by blocking turnover of the stationary neurofilament network.

PubMed

Rao, Mala V; Yuan, Aidong; Campbell, Jabbar; Kumar, Asok; Nixon, Ralph A

2012-01-01

Newly synthesized neurofilaments or protofilaments are incorporated into a highly stable stationary cytoskeleton network as they are transported along axons. Although the heavily phosphorylated carboxyl-terminal tail domains of the heavy and medium neurofilament (NF) subunits have been proposed to contribute to this process and particularly to stability of this structure, their function is still obscure. Here we show in NF-H/M tail deletion [NF-(H/M)(tailΔ)] mice that the deletion of both of these domains selectively lowers NF levels 3-6 fold along optic axons without altering either rates of subunit synthesis or the rate of slow axonal transport of NF. Pulse labeling studies carried out over 90 days revealed a significantly faster rate of disappearance of NF from the stationary NF network of optic axons in NF-(H/M)(tailΔ) mice. Faster NF disappearance was accompanied by elevated levels of NF-L proteolytic fragments in NF-(H/M)(tailΔ) axons. We conclude that NF-H and NF-M C-terminal domains do not normally regulate NF transport rates as previously proposed, but instead increase the proteolytic resistance of NF, thereby stabilizing the stationary neurofilament cytoskeleton along axons.

The C-Terminal Domains of NF-H and NF-M Subunits Maintain Axonal Neurofilament Content by Blocking Turnover of the Stationary Neurofilament Network

PubMed Central

Rao, Mala V.; Yuan, Aidong; Campbell, Jabbar; Kumar, Asok; Nixon, Ralph A.

2012-01-01

Newly synthesized neurofilaments or protofilaments are incorporated into a highly stable stationary cytoskeleton network as they are transported along axons. Although the heavily phosphorylated carboxyl-terminal tail domains of the heavy and medium neurofilament (NF) subunits have been proposed to contribute to this process and particularly to stability of this structure, their function is still obscure. Here we show in NF-H/M tail deletion [NF-(H/M)tailΔ] mice that the deletion of both of these domains selectively lowers NF levels 3–6 fold along optic axons without altering either rates of subunit synthesis or the rate of slow axonal transport of NF. Pulse labeling studies carried out over 90 days revealed a significantly faster rate of disappearance of NF from the stationary NF network of optic axons in NF-(H/M)tailΔ mice. Faster NF disappearance was accompanied by elevated levels of NF-L proteolytic fragments in NF-(H/M)tailΔ axons. We conclude that NF-H and NF-M C-terminal domains do not normally regulate NF transport rates as previously proposed, but instead increase the proteolytic resistance of NF, thereby stabilizing the stationary neurofilament cytoskeleton along axons. PMID:23028520

Screening for germline mutations in the neurofibromatosis type 2 (NF2) gene in NF2 patients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Andermann, A.A.; Ruttledge, M.H.; Rangaratnam, A.

Neurofibromatosis type 2 (NF2) is an autosomal dominant disease with over 95% penetrance which predisposes gene carriers to develop multiple tumors of the central nervous system. The NF2 gene is a putative tumor suppressor gene which was previously mapped to the long arm of chromosome 22, and has recently been identified, using positional cloning techniques. The gene encodes a protein, schwannomin (SCH), which is highly homologous to the band 4.1 protein family. In an attempt to identify and characterize mutations which lead to the manifestation of the disease, we have used single strand conformation analysis (SSCA) to screen for germlinemore » mutations in all 17 exons of the NF2 gene in 59 unrelated NF2 patients, representing both familial and new mutations. A total of 27 migration abnormalities was found in 26 patients. Using direct sequencing analysis, the majority of these variants were found to result in nonsense, splice-site or frameshift mutations. Mutations identified in familial NF2 patients segregate in the family, and may prove to be useful tools for a simple and direct SSCA-based technique of presymptomatic or prenatal diagnosis in relatives of patients with NF2. This may be of particular importance in children of patients who have new mutations in the NF2 gene, where linkage analysis may not be feasible.« less

Amorfrutin A inhibits TNF-α-induced NF-κB activation and NF-κB-regulated target gene products.

PubMed

Shi, Hui; Ma, Juan; Mi, Chunliu; Li, Jing; Wang, Fei; Lee, Jung Joon; Jin, Xuejun

2014-07-01

The nuclear factor-κB (NF-κB) transcription factors control many physiological processes including inflammation, immunity, apoptosis, and angiogenesis. In our search for NF-κB inhibitors from natural resources, we identified amorfrutin A as an inhibitor of NF-κB activation from the fruits of Amorpha fruticosa L. In present study, this compound significantly inhibited the TNF-α-induced expression of NF-κB reporter gene. Further analysis revealed that amorfrutin A was a potent inhibitor of NF-κB activation by the suppression of TNF-α-induced inhibitor of κBα (IκBα) degradation, p65 nuclear translocation, and DNA-binding activity of NF-κB. We also demonstrated that pretreatment of cells with this compound prevented the TNF-α-induced expression of NF-κB target genes, such as antiapoptosis (cIAP-1 and FLIP), proliferation (COX-2 and cyclinD1), invasion (MMP-9), angiogenesis (VEGF), and major inflammatory cytokines (TNF-α, IL-8, and MCP1). Furthermore, our results suggest that amorfrutin A potentiates TNF-α-induced apoptosis. Taken together, amorfrutin A could be a valuable candidate for the intervention of NF-κB-dependent pathological conditions such as inflammation. Copyright © 2014 Elsevier B.V. All rights reserved.

NF-κB Signalling in Glioblastoma

PubMed Central

Soubannier, Vincent; Stifani, Stefano

2017-01-01

Nuclear factor-κB (NF-κB) is a transcription factor regulating a wide array of genes mediating numerous cellular processes such as proliferation, differentiation, motility and survival, to name a few. Aberrant activation of NF-κB is a frequent event in numerous cancers, including glioblastoma, the most common and lethal form of brain tumours of glial cell origin (collectively termed gliomas). Glioblastoma is characterized by high cellular heterogeneity, resistance to therapy and almost inevitable recurrence after surgery and treatment. NF-κB is aberrantly activated in response to a variety of stimuli in glioblastoma, where its activity has been implicated in processes ranging from maintenance of cancer stem-like cells, stimulation of cancer cell invasion, promotion of mesenchymal identity, and resistance to radiotherapy. This review examines the mechanisms of NF-κB activation in glioblastoma, the involvement of NF-κB in several mechanisms underlying glioblastoma propagation, and discusses some of the important questions of future research into the roles of NF-κB in glioblastoma. PMID:28598356

Legionnaires' Disease Outbreak Caused by Endemic Strain of Legionella pneumophila, New York, New York, USA, 2015.

PubMed

Lapierre, Pascal; Nazarian, Elizabeth; Zhu, Yan; Wroblewski, Danielle; Saylors, Amy; Passaretti, Teresa; Hughes, Scott; Tran, Anthony; Lin, Ying; Kornblum, John; Morrison, Shatavia S; Mercante, Jeffrey W; Fitzhenry, Robert; Weiss, Don; Raphael, Brian H; Varma, Jay K; Zucker, Howard A; Rakeman, Jennifer L; Musser, Kimberlee A

2017-11-01

During the summer of 2015, New York, New York, USA, had one of the largest and deadliest outbreaks of Legionnaires' disease in the history of the United States. A total of 138 cases and 16 deaths were linked to a single cooling tower in the South Bronx. Analysis of environmental samples and clinical isolates showed that sporadic cases of legionellosis before, during, and after the outbreak could be traced to a slowly evolving, single-ancestor strain. Detection of an ostensibly virulent Legionella strain endemic to the Bronx community suggests potential risk for future cases of legionellosis in the area. The genetic homogeneity of the Legionella population in this area might complicate investigations and interpretations of future outbreaks of Legionnaires' disease.

Legionnaires’ Disease Outbreak Caused by Endemic Strain of Legionella pneumophila, New York, New York, USA, 2015

PubMed Central

Nazarian, Elizabeth; Zhu, Yan; Wroblewski, Danielle; Saylors, Amy; Passaretti, Teresa; Hughes, Scott; Tran, Anthony; Lin, Ying; Kornblum, John; Morrison, Shatavia S.; Mercante, Jeffrey W.; Fitzhenry, Robert; Weiss, Don; Raphael, Brian H.; Varma, Jay K.; Zucker, Howard A.; Rakeman, Jennifer L.; Musser, Kimberlee A.

2017-01-01

During the summer of 2015, New York, New York, USA, had one of the largest and deadliest outbreaks of Legionnaires’ disease in the history of the United States. A total of 138 cases and 16 deaths were linked to a single cooling tower in the South Bronx. Analysis of environmental samples and clinical isolates showed that sporadic cases of legionellosis before, during, and after the outbreak could be traced to a slowly evolving, single-ancestor strain. Detection of an ostensibly virulent Legionella strain endemic to the Bronx community suggests potential risk for future cases of legionellosis in the area. The genetic homogeneity of the Legionella population in this area might complicate investigations and interpretations of future outbreaks of Legionnaires’ disease. PMID:29047425

Hydrogeology of the Croton-Ossining area, Westchester County, New York

USGS Publications Warehouse

Reynolds, Richard J.

1988-01-01

The hydrogeology of a 29-sq-mi area surrounding the village of Croton-on-Hudson, New York, is summarized on 6 sheets at 1:12 ,000 scale that show locations of wells and test holes, surficial geology, geologic sections, bedrock geology, land use, and soil permeability. The primary stratified-drift aquifer in this area is the Croton River aquifer, which consists of outwash sand and gravel that partly fills the Croton River valley from the New Croton Dam to the Hudson River--a distance of approximately 3 miles. The valley is narrow and ranges in width from 100 to 1,900 ft, and its v-notch bedrock floor ranges from 30 to 50 ft below sea level. Detailed hydrogeologic studies during 1936-38 showed the stratigraphy to consist of an upper water-table aquifer with a saturated thickness of about 35 ft, underlain by a silt and clay confining unit 8 to o0 ft in thickness that in turn is underlain by a lower confined outwash aquifer up to 40 ft thick. Aquifer-test data and laboratory permeability tests show that the average hydraulic conductivity of the upper outwash aquifer is 475 ft/d, and that of the lower confined aquifer is about 300 ft/d. The aquifer is recharged through direct precipitation, runoff from adjacent hillsides, and leakage under the new Croton Dam. Previous studies estimate the average leakage under the dam to be 0.65 Mgal/d and the total average daily recharge to the aquifer between New Croton Dam and Quaker Bridge to be 1.73 Mgal/d. (USGS)

Clinical and Molecular Consequences of NF1 Microdeletion

DTIC Science & Technology

2005-05-01

and Cell Biology of NFl, NF2 and Schwannomatosis , Aspen, June, 2005 "* Abstract: Shinohara MM, Kuechle MK, Graves J, Stephens K. Neurofibromin is a...caspase target. The CTF International Consortium for the Molecular and Cell Biology of NF1, NF2 and Schwannomatosis , Aspen, June, 2005. "* Abstract...Molecular and Cell Biology of NF1, NF2 and Schwannomatosis , Aspen, June, 2005 Abstract: Shinohara MM, Kuechle MK, Graves J, Stephens K. Neurofibromin is a

48 CFR 242.002 - Interagency agreements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Interagency agreements. 242.002 Section 242.002 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES 242.002 Interagency...

Performance and fate of organics in a pilot MBR-NF for treating antibiotic production wastewater with recycling NF concentrate.

PubMed

Wang, Jianxing; Li, Kun; Wei, Yuansong; Cheng, Yutao; Wei, Dongbin; Li, Mingyue

2015-02-01

A double membrane system comprising a membrane bioreactor (MBR) combined with a nanofiltration (NF) membrane was investigated on a pilot scale for the treatment of antibiotic production wastewater over a three-month period at a pharmaceutical company in Wuxi, China. By recycling the NF concentrate, the combined MBR-NF process was shown to be effective for the treatment of antibiotic production wastewater, resulting in excellent water quality and a high water yield of 92±5.6%. The water quality of the pilot-scale MBR-NF process was excellent; e.g., the concentrations of TOC, NH4(+)-N, TP were stable at 5.52, 0.68, 0.34 mg L(-1), respectively, and the values of turbidity and conductivity of the NF permeate were 0.15 NTU and 2.5 mS cm(-1), respectively; these values meet China's water quality standard requirements for industrial use (GB21903-2008). Not only were the antibiotic removal rates of spiramycin (SPM) and new spiramycin (NSPM) over 95%, the acute toxicity was also drastically reduced by the MBR-NF pilot system. The main organics in the MBR effluent were proteins, polysaccharides, and humic-like substances; they were almost completely retained by the NF membrane and further biodegraded in the MBR because the NF concentrate was recycled. The microbial community of the MBR did not significantly change with the recycling of the NF concentrate. Copyright © 2014 Elsevier Ltd. All rights reserved.

46 CFR 160.002-4 - Construction.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 6 2013-10-01 2013-10-01 false Construction. 160.002-4 Section 160.002-4 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS... and 5 § 160.002-4 Construction. (a) General. This specification covers life preservers which...

46 CFR 160.002-4 - Construction.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 6 2011-10-01 2011-10-01 false Construction. 160.002-4 Section 160.002-4 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS... and 5 § 160.002-4 Construction. (a) General. This specification covers life preservers which...

46 CFR 160.002-4 - Construction.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 6 2014-10-01 2014-10-01 false Construction. 160.002-4 Section 160.002-4 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS... and 5 § 160.002-4 Construction. (a) General. This specification covers life preservers which...

46 CFR 160.002-4 - Construction.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 6 2012-10-01 2012-10-01 false Construction. 160.002-4 Section 160.002-4 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS... and 5 § 160.002-4 Construction. (a) General. This specification covers life preservers which...

The Effects of GATA-1 and NF-E2 Deficiency on Bone Biomechanical, Biochemical, and Mineral Properties

PubMed Central

Kacena, Melissa A.; Gundberg, Caren M.; Kacena, William J.; Landis, William J.; Boskey, Adele L.; Bouxsein, Mary L.; Horowitz, Mark C.

2014-01-01

Mice deficient in GATA-1 or NF-E2, transcription factors required for normal megakaryocyte (MK) development, have increased numbers of MKs, reduced numbers of platelets, and a striking high bone mass phenotype. Here, we show the bone geometry, microarchitecture, biomechanical, biochemical, and mineral properties from these mutant mice. We found that the outer geometry of the mutant bones was similar to controls, but that both mutants had a striking increase in total bone area (up to a 35% increase) and trabecular bone area (up to a 19% increase). Interestingly, only the NF-E2 deficient mice had a significant increase in cortical bone area (21%) and cortical thickness (27%), which is consistent with the increase in bone mineral density (BMD) seen only in the NF-E2 deficient femurs. Both mutant femurs exhibited significant increases in several biomechanical properties including peak load (up to a 32% increase) and stiffness (up to a 13% increase). Importantly, the data also demonstrate differences between the two mutant mice. GATA-1 deficient femurs break in a ductile manner, whereas NF-E2 deficient femurs are brittle in nature. To better understand these differences, we examined the mineral properties of these bones. Although none of the parameters measured were different between the NF-E2 deficient and control mice, an increase in calcium (21%) and an increase in the mineral/matrix ratio (32%) was observed in GATA-1 deficient mice. These findings appear to contradict biomechanical findings, suggesting the need for further research into the mechanisms by which GATA-1 and NF-E2 deficiency alter the material properties of bone. PMID:23359245

Rig-I regulates NF-κB activity through binding to Nf-κb1 3′-UTR mRNA

PubMed Central

Zhang, Hong-Xin; Liu, Zi-Xing; Sun, Yue-Ping; Lu, Shun-Yuan; Liu, Xue-Song; Huang, Qiu-Hua; Xie, Yin-Yin; Dang, Su-Ying; Zheng, Guang-Yong; Li, Yi-Xue; Kuang, Ying; Fei, Jian; Chen, Zhu; Wang, Zhu-Gang

2013-01-01

Retinoic acid inducible gene I (RIG-I) senses viral RNAs and triggers innate antiviral responses through induction of type I IFNs and inflammatory cytokines. However, whether RIG-I interacts with host cellular RNA remains undetermined. Here we report that Rig-I interacts with multiple cellular mRNAs, especially Nf-κb1. Rig-I is required for NF-κB activity via regulating Nf-κb1 expression at posttranscriptional levels. It interacts with the multiple binding sites within 3′-UTR of Nf-κb1 mRNA. Further analyses reveal that three distinct tandem motifs enriched in the 3′-UTR fragments can be recognized by Rig-I. The 3′-UTR binding with Rig-I plays a critical role in normal translation of Nf-κb1 by recruiting the ribosomal proteins [ribosomal protein L13 (Rpl13) and Rpl8] and rRNAs (18S and 28S). Down-regulation of Rig-I or Rpl13 significantly reduces Nf-κb1 and 3′-UTR–mediated luciferase expression levels. These findings indicate that Rig-I functions as a positive regulator for NF-κB signaling and is involved in multiple biological processes in addition to host antivirus immunity. PMID:23553835

10 CFR 800.002 - Program management.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Program management. 800.002 Section 800.002 Energy DEPARTMENT OF ENERGY LOANS FOR BID OR PROPOSAL PREPARATION BY MINORITY BUSINESS ENTERPRISES SEEKING DOE CONTRACTS AND ASSISTANCE General § 800.002 Program management. Program management responsibility for...

10 CFR 800.002 - Program management.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Program management. 800.002 Section 800.002 Energy DEPARTMENT OF ENERGY LOANS FOR BID OR PROPOSAL PREPARATION BY MINORITY BUSINESS ENTERPRISES SEEKING DOE CONTRACTS AND ASSISTANCE General § 800.002 Program management. Program management responsibility for...

10 CFR 800.002 - Program management.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Program management. 800.002 Section 800.002 Energy DEPARTMENT OF ENERGY LOANS FOR BID OR PROPOSAL PREPARATION BY MINORITY BUSINESS ENTERPRISES SEEKING DOE CONTRACTS AND ASSISTANCE General § 800.002 Program management. Program management responsibility for...

10 CFR 800.002 - Program management.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Program management. 800.002 Section 800.002 Energy DEPARTMENT OF ENERGY LOANS FOR BID OR PROPOSAL PREPARATION BY MINORITY BUSINESS ENTERPRISES SEEKING DOE CONTRACTS AND ASSISTANCE General § 800.002 Program management. Program management responsibility for...

10 CFR 800.002 - Program management.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Program management. 800.002 Section 800.002 Energy DEPARTMENT OF ENERGY LOANS FOR BID OR PROPOSAL PREPARATION BY MINORITY BUSINESS ENTERPRISES SEEKING DOE CONTRACTS AND ASSISTANCE General § 800.002 Program management. Program management responsibility for...

Hydrology of area 2, Eastern Coal Province, Pennsylvania and New York

USGS Publications Warehouse

Herb, W.J.; Brown, D.E.; Shaw, L.C.; Stoner, J.E.; Felbinger, J.K.

1983-01-01

Provisions of the Surface Mining Control and Reclamation Act of 1977 recognized a nationwide need for hydrologic information in mined and potentially mined areas. This report is designed to be useful to mine owners, operators, regulatory authorities, citizens groups, and others by presenting information on existing hydrologic conditions and by identifying additional sources of hydrologic information. General hydrologic information is presented in a brief text accompanied by a map, chart, graph, or other illustration for each of a series of water-resourcesrelated topics. The summation of the topical discussions provides a description of the hydrology of the area. The Eastern Coal Province has been divided into 24 hydrologic study areas which are shown on the cover of this report. The divisions are based on hydrologic factors, location, and size. Hydrologic units (surface drainage basins) or parts of units are combined to form each study area. Study Area 2 covers northwestern Pennsylvania and a small part of southwestern New York. Most exposed bedrock is of Pennsylvanian, Mi;;sissippian, or Devonian ages. Glacial drift covers most of the bedrock in the northwestern part of the area. During 1979, more than 7 million tons of bituminous coal was produced from about 230 mines in Area 2 counties. Over 99 percent of the area's coal production is from surface mining. Streamflow data are available for 18 continuousrecord stations; 1 crest-stage, partial-record station; 1 low-flow, partial-record station; and 65 miscellaneous sites. Water-quality data are available for 78 locations. Streams having the highest median specific conductance, highest median dissolved-solids concentrations, lowest median pH, highest median total-iron concentration, highest median total-manganese concentration, and highest dissolved-sulfate concentrations were found in Clarion County, the leading coal-producing county in the area. Statistics on low flow, mean flow, peak flow, and flow duration for

NF-κB signaling participates in both Receptor Activator of NF-κB Ligand- (RANKL) and interleukin-4- (IL-4) induced macrophage fusion: Receptor cross-talk leads to alterations in NF-κB pathways

PubMed Central

Yu, Minjun; Qi, Xiulan; Moreno, Jose L.; Farber, Donna L.; Keegan, Achsah D.

2011-01-01

NF-κB activation is essential for RANKL-induced osteoclast formation. IL-4 is known to inhibit the RANKL-induced osteoclast differentiation, while at the same time promote macrophage fusion to form multinucleated giant cells (MNG). Several groups have proposed that IL-4 inhibition of osteoclastogenesis is mediated by suppressing the RANKL-induced activation of NF-κB. However, we found that IL-4 did not block proximal, canonical NF-κB signaling. Instead, we found that IL-4 inhibited alternative NF-κB signaling and induced p105/50 expression. Interestingly, in nfκb1−/− bone marrow macrophages (BMM), the formation of both multinucleated osteoclast and MNG induced by RANKL or IL-4 respectively was impaired. This suggests that NF-κB signaling also plays an important role in IL-4-induced macrophage fusion. Indeed, we found that the RANKL-induced and IL-4-induced macrophage fusion were both inhibited by the NF-κB inhibitors IKK2 inhibitor, and NEMO inhibitory peptide. Furthermore, overexpression of p50, p65, p52 and RelB individually in nfκb1−/− or nfκb1+/+ BMM enhanced both giant osteoclast and MNG formation. Interestingly, knockdown of nfκb2 in wild type BMM dramatically enhanced both osteoclast and MNG formation. In addition, both RANKL- and IL-4-induced macrophage fusion were impaired in NIK−/− BMM. These results suggest IL-4 influences NF-κB pathways by increasing p105/p50 and suppressing RANKL-induced p52 translocation, and that NF-κB pathways participate in both RANKL- and IL-4- induced giant cell formation. PMID:21734075

40 CFR 81.127 - Central New York Intrastate Air Quality Control Region.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Central New York Intrastate Air... Air Quality Control Regions § 81.127 Central New York Intrastate Air Quality Control Region. The Central New York Intrastate Air Quality Control Region consists of the territorial area encompassed by the...

NF-κB deregulation in Hodgkin lymphoma.

PubMed

Weniger, Marc A; Küppers, Ralf

2016-08-01

Hodgkin and Reed/Sternberg (HRS) cells in classical Hodgkin lymphoma (HL) show constitutive activity of both the canonical and non-canonical NF-κB signaling pathways. The central pathogenetic role of this activity is indicated from studies with HL cell lines, which undergo apoptosis upon NF-κB inhibition. Multiple factors contribute to the strong NF-κB activity of HRS cells. This includes interaction with other cells in the lymphoma microenvironment through CD30, CD40, BCMA and other receptors, but also recurrent somatic genetic lesions in various factors of the NF-κB pathway, including destructive mutations in negative regulators of NF-κB signaling (e.g. TNFAIP3, NFKBIA), and copy number gains of genes encoding positive regulators (e.g. REL, MAP3K14). In Epstein-Barr virus-positive cases of classical HL, the virus-encoded latent membrane protein 1 causes NF-κB activation by mimicking an active CD40 receptor. NF-κB activity is also seen in the tumor cells of the rare nodular lymphocyte predominant form of HL, but the causes for this activity are largely unclear. Copyright © 2016 Elsevier Ltd. All rights reserved.

Athletic participation in children with symptomatic spondylolysis in the New York area.

PubMed

Ladenhauf, Hannah N; Fabricant, Peter D; Grossman, Eric; Widmann, Roger F; Green, Daniel W

2013-10-01

The purpose of this study was to assess athletic activities associated with spondylolysis in children and adolescents in a New York metropolitan tertiary referral center. We retrospectively evaluated 137 consecutive cases of symptomatic spondylolysis presenting to one of two pediatric orthopedic spine surgeons. Ten patients who did not participate in any organized athletics were excluded, leaving 127 children for analysis. Data regarding spondylolysis and athletic participation were gathered for analysis. One hundred and twenty-seven patients were analyzed (mean age, 13.9 ± 2.2 yr). All patients had initial x-rays, with nearly all obtaining further advanced level imaging to confirm the diagnosis of spondylolysis. Magnetic resonance imaging was obtained in 42.5% of cases, limited computed tomography scan in 29.1% of cases, and single-photon emission computed tomography scan in 23.6% of cases. The most common location of spondylolysis was at the L5 level (74%), of which 43.6% were bilateral. Of the overall cohort, 2.4% had spondylolysis at multiple levels. The most common athletic activities associated with spondylolysis in this cohort were soccer (19.3%), basketball (17.2%), and lacrosse (9.4%). Although previous reports have implicated participation in various sports in the development of symptomatic spondylolysis in children, lacrosse and baseball have rarely been associated with spondylolysis. We found that in the New York metropolitan area, soccer, basketball, lacrosse, baseball, tennis, and football were most commonly associated with spondylolysis. Therefore, we emphasize consideration of spondylolysis in these children if they present with low back pain. These results may be used to counsel parents and young athletes about the possibility of spondylolysis as an etiology of lumbar back pain and in educating coaches, teachers, school nurses, and primary care providers.

NF-κB Activation Protects Oligodendrocytes against Inflammation

PubMed Central

Stone, Sarrabeth; Jamison, Stephanie; Yue, Yuan; Durose, Wilaiwan

2017-01-01

NF-κB is a key player in inflammatory diseases, including multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). However, the effects of NF-κB activation on oligodendrocytes in MS and EAE remain unknown. We generated a mouse model that expresses IκBαΔN, a super-suppressor of NF-κB, specifically in oligodendrocytes and demonstrated that IκBαΔN expression had no effect on oligodendrocytes under normal conditions (both sexes). Interestingly, we showed that oligodendrocyte-specific expression of IκBαΔN blocked NF-κB activation in oligodendrocytes and resulted in exacerbated oligodendrocyte death and hypomyelination in young, developing mice that express IFN-γ ectopically in the CNS (both sexes). We also showed that NF-κB inactivation in oligodendrocytes aggravated IFN-γ-induced remyelinating oligodendrocyte death and remyelination failure in the cuprizone model (male mice). Moreover, we found that NF-κB inactivation in oligodendrocytes increased the susceptibility of mice to EAE (female mice). These findings imply the cytoprotective effects of NF-κB activation on oligodendrocytes in MS and EAE. SIGNIFICANCE STATEMENT Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. NF-κB is a major player in inflammatory diseases that acts by regulating inflammation and cell viability. Data indicate that NF-κB activation in inflammatory cells facilitates the development of MS. However, to date, attempts to understand the role of NF-κB activation in oligodendrocytes in MS have been unsuccessful. Herein, we generated a mouse model that allows for inactivation of NF-κB specifically in oligodendrocytes and then used this model to determine the precise role of NF-κB activation in oligodendrocytes in models of MS. The results presented in this study represent the first demonstration that NF-κB activation acts cell autonomously to protect oligodendrocytes against inflammation in animal models of MS

Blocking NF-κB: an inflammatory issue.

PubMed

Rahman, Arshad; Fazal, Fabeha

2011-11-01

The nuclear factor (NF)-κB is considered the master regulator of inflammatory responses. Studies in mouse models have established this transcription factor as an important mediator of many inflammatory disease states, including pulmonary diseases such as acute lung injury and acute respiratory distress syndrome. Endothelial cells provide the first barrier for leukocytes migrating to the inflamed sites and hence offer an attractive cellular context for targeting NF-κB for treatment of these diseases. However, recent studies showing that NF-κB also plays an important role in resolution phase of inflammation and in tissue repair and homeostasis have challenged the view of therapeutic inhibition of NF-κB. This article reviews the regulation of NF-κB in the context of endothelial cell signaling and provides a perspective on why "dampening" rather than "abolishing" NF-κB activation may be a safe and effective treatment strategy for inflammation-associated pulmonary and other inflammatory diseases.

48 CFR 23.002 - Policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Policy. 23.002 Section 23.002 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE...

48 CFR 23.002 - Policy.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Policy. 23.002 Section 23.002 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE...

48 CFR 23.002 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Policy. 23.002 Section 23.002 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE...

48 CFR 23.002 - Policy.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Policy. 23.002 Section 23.002 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE...

48 CFR 923.002 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., CONSERVATION, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE 923.002 Policy. (a) Requirement. FAR 23.002 and Section 3(e) of Executive Order 13423, Strengthening Federal Environmental, Energy and Transportation..., Strengthening Federal Environmental, Energy, and Transportation Management, in contracts for Contractor...

48 CFR 210.002 - Procedures.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Section 210.002 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE ACQUISITION PLANNING MARKET RESEARCH 210.002 Procedures. When contracting for services, see the market research report guide for improving the tradecraft in services acquisition at PGI 210...

48 CFR 210.002 - Procedures.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Section 210.002 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE ACQUISITION PLANNING MARKET RESEARCH 210.002 Procedures. When contracting for services, see the market research report guide for improving the tradecraft in services acquisition at PGI 210...

48 CFR 210.002 - Procedures.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Section 210.002 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE ACQUISITION PLANNING MARKET RESEARCH 210.002 Procedures. When contracting for services, see the market research report guide for improving the tradecraft in services acquisition at PGI 210...

Rural Transportation in New York State: A Preliminary Report.

ERIC Educational Resources Information Center

New York State Legislative Commission on Rural Resources, Albany.

The report catalogs strengths, defines problems, and establishes goals for the next two decades for rural New York in the area of transportation. Describing where rural New York is today, section one lists 12 trends, 8 strengths, and 16 weaknesses affecting transporation. Trends include increased rural population inflow and demands on local…

NF-κB Signaling in Gastric Cancer

PubMed Central

Sokolova, Olga; Naumann, Michael

2017-01-01

Gastric cancer is a leading cause of cancer death worldwide. Diet, obesity, smoking and chronic infections, especially with Helicobacter pylori, contribute to stomach cancer development. H. pylori possesses a variety of virulence factors including encoded factors from the cytotoxin-associated gene pathogenicity island (cagPAI) or vacuolating cytotoxin A (VacA). Most of the cagPAI-encoded products form a type 4 secretion system (T4SS), a pilus-like macromolecular transporter, which translocates CagA into the cytoplasm of the host cell. Only H. pylori strains carrying the cagPAI induce the transcription factor NF-κB, but CagA and VacA are dispensable for direct NF-κB activation. NF-κB-driven gene products include cytokines/chemokines, growth factors, anti-apoptotic factors, angiogenesis regulators and metalloproteinases. Many of the genes transcribed by NF-κB promote gastric carcinogenesis. Since it has been shown that chemotherapy-caused cellular stress could elicit activation of the survival factor NF-κB, which leads to acquisition of chemoresistance, the NF-κB system is recommended for therapeutic targeting. Research is motivated for further search of predisposing conditions, diagnostic markers and efficient drugs to improve significantly the overall survival of patients. In this review, we provide an overview about mechanisms and consequences of NF-κB activation in gastric mucosa in order to understand the role of NF-κB in gastric carcinogenesis. PMID:28350359

48 CFR 2910.002 - Procedures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Section 2910.002 Federal Acquisition Regulations System DEPARTMENT OF LABOR ACQUISITION PLANNING MARKET RESEARCH 2910.002 Procedures. (a) In accordance with FAR 6.302-1(c), purchase descriptions must not specify... Contracts, should include product information concerning multiple sources based on research from www...

48 CFR 2910.002 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 2910.002 Federal Acquisition Regulations System DEPARTMENT OF LABOR ACQUISITION PLANNING MARKET RESEARCH 2910.002 Procedures. (a) In accordance with FAR 6.302-1(c), purchase descriptions must not specify... Contracts, should include product information concerning multiple sources based on research from www...

78 FR 72032 - Approval and Promulgation of Air Quality Implementation Plans; New York; Determination of Clean...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-02

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 [Docket No. EPA-R02-OAR-2013-0618; FRL-9903-24... Data for the 1987 PM 10 Standard for the New York County Area AGENCY: Environmental Protection Agency... New York County nonattainment area in New York is attaining the National Ambient Air Quality Standard...

40 CFR Table 31 to Subpart G of... - Typical Number of Vacuum Breakers, NF6 and Roof Drains, a NF7

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 10 2013-07-01 2013-07-01 false Typical Number of Vacuum Breakers, NF6..., and Wastewater Pt. 63, Subpt. G, Table 31 Table 31 to Subpart G of Part 63—Typical Number of Vacuum Breakers, NF6 and Roof Drains, a NF7 Tank diameter D (feet) b No. of vacuum breakers, NF6 Pontoon roof...

The Forgotten Minority: Asian Americans in New York City.

ERIC Educational Resources Information Center

New York State Advisory Committee to the U.S. Commission on Civil Rights, New York.

Approximately 2.1 percent of New York City's population is Asian American. This report is concerned with the difficulties faced by members of the Chinese, Japanese, Filipino and Korean communities in the areas of immigration, employment, and as a result of media stereotyping of Asians. An overview of individual Asian communities in New York is…

PARTICULATE ORGANIC SOURCE MARKERS IN THE NEW YORK CITY METROPOLITAN AREA

EPA Science Inventory

A sampling network of four sites was established for the Speciation of Organics for Apportionment of PM2.5 (SOAP) project during 2002-2003 to investigate composition, seasonal and spatial variability, and source contributions to particulate organic matter in the New York City met...

MicroRNA-22 and microRNA-140 suppress NF-{kappa}B activity by regulating the expression of NF-{kappa}B coactivators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Takata, Akemi; Otsuka, Motoyuki, E-mail: otsukamo-tky@umin.ac.jp; Kojima, Kentaro

2011-08-12

Highlights: {yields} miRNAs were screened for their ability to regulate NF-{kappa}B activity. {yields} miRNA-22 and miRNA-140-3p suppress NF-{kappa}B activity by regulating coactivators. {yields} miRNA-22 targets nuclear receptor coactivator 1 (NCOA1). {yields} miRNA-140-3p targets nuclear receptor-interacting protein 1 (NRIP1). -- Abstract: Nuclear factor {kappa}B (NF-{kappa}B) is a transcription factor that regulates a set of genes that are critical to many biological phenomena, including liver tumorigenesis. To identify microRNAs (miRNAs) that regulate NF-{kappa}B activity in the liver, we screened 60 miRNAs expressed in hepatocytes for their ability to modulate NF-{kappa}B activity. We found that miRNA-22 and miRNA-140-3p significantly suppressed NF-{kappa}B activity bymore » regulating the expression of nuclear receptor coactivator 1 (NCOA1) and nuclear receptor-interacting protein 1 (NRIP1), both of which are NF-{kappa}B coactivators. Our results provide new information about the roles of miRNAs in the regulation of NF-{kappa}B activity.« less

Hazardous Waste Cleanup: Black & Decker Incorporated in Brockport, New York

EPA Pesticide Factsheets

The facility is located at 200 State Street in Brockport, New York, on approximately 28.6 acres in a largely industrial area. The facility is bounded to the north by State Street and the New York State Barge Canal, to the east by an Owens-Illinois facilit

Acetaminophen-induced hepatotoxicity is associated with early changes in NF-kB and NF-IL6 DNA binding activity.

PubMed

Blazka, M E; Germolec, D R; Simeonova, P; Bruccoleri, A; Pennypacker, K R; Luster, M I

Nuclear transcription factors, such as NF-kB and NF-IL6, are believed to play an important role in regulating the expression of genes that encode for products involved in tissue damage and inflammation and, thus, may represent early biomarkers for chemical toxicities. In the present study changes in DNA binding activity of these factors were examined in livers of mice administered hepatotoxic doses of acetaminophen (APAP). NF-kB and NF-IL6 DNA binding occurred constitutively in control mouse liver. However, within 4 hr following administration of hepatotoxic doses of APAP, their binding activities were transiently lost and is in contrast to AP-1 transcription factor where activation occurs under similar conditions. These changes corresponded with increased release of inflammatory mediators (IL-6, serum amyloid A) and increased levels of enzymatic markers of hepatocyte damage. Similarly, treatment of mice with gadolinium chloride, an inhibitor of Kupffer cell activation and known to protect against APAP-induced hepatotoxicity, reduced the observed pathophysiological response in the liver while altering the APAP-associated changes in NF-kB DNA binding activity. NF-kB was found predominantly in parenchymal and endothelial cells and was composed primarily of relatively inactive p50 homodimer subunits in control liver. Taken together, these studies suggest that hepatotoxicity is associated with early and complex changes in DNA binding activities of specific transcription factors. In particular, NF-kB and NF-IL6 may serve as negative regulators of hepatocyte-derived inflammatory mediators and is analogous to that previously observed in certain other cell systems such as B lymphocytes.

24 CFR 570.421 - New York Small Cities Program design.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false New York Small Cities Program... HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES COMMUNITY DEVELOPMENT BLOCK GRANTS Small Cities, Non-Entitlement CDBG Grants in Hawaii and Insular Areas Programs § 570.421 New York Small Cities Program design...

Functional Analysis of Human NF1 in Drosophila

DTIC Science & Technology

2008-12-01

also have learning problem. Such learning phenotypes have been recapitulated in animal models, including in mouse and Drosophila mutants. This proposal...by examining the phenotypes of mutated human genes expressed in Drosophila NF1 null mutants. We also propose that Gsα/NF1 activated AC pathway...in both Drosophila and mouse NF1 models. Our previous work has shown that defective cAMP signaling leads to the learning phenotype in Drosophila Nf1

NF-κB as a target for oncogenic viruses

PubMed Central

Sun, Shao-Cong; Cesarman, Ethel

2013-01-01

NF-κB is a pivotal transcription factor that controls cell survival and proliferation in diverse physiological processes. The activity of NF-κB is tightly controlled through its cytoplasmic sequestration by specific inhibitors, IκBs. Various cellular stimuli induce the activation of an IκB kinase (IKK), which phosphorylates IκBs and triggers their proteasomal degradation, causing nuclear translocation of activated NF-κB. Under normal conditions, the activation of NF-κB occurs transiently, thus ensuring rapid but temporary induction of target genes. Deregulated NF-κB activation contributes to the development of various diseases, including cancers and immunological disorders. Accumulated studies demonstrate that the NF-κB signaling pathway is a target of several human oncogenic viruses, including the human T-cell leukemia virus type 1 (HTLV1), the Kaposi sarcoma-associated herpesvirus (KSHV), and the Epstein bar virus (EBV). These viruses encode specific oncoproteins that target different signaling components of the NF-κB pathway, leading to persistent activation of NF-κB. This chapter will discuss the molecular mechanisms by which NF-κB is activated by the viral oncoproteins. PMID:20845110

Delineation of areas contributing groundwater to selected receiving surface water bodies for long-term average hydrologic conditions from 1968 to 1983 for Long Island, New York

USGS Publications Warehouse

Misut, Paul E.; Monti,, Jack

2016-10-05

To assist resource managers and planners in developing informed strategies to address nitrogen loading to coastal water bodies of Long Island, New York, the U.S. Geological Survey and the New York State Department of Environmental Conservation initiated a program to delineate a comprehensive dataset of groundwater recharge areas (or areas contributing groundwater), travel times, and outflows to streams and saline embayments on Long Island. A four-layer regional three-dimensional finite-difference groundwater-flow model of hydrologic conditions from 1968 to 1983 was used to provide delineations of 48 groundwater watersheds on Long Island. Sixteen particle starting points were evenly spaced within each of the 4,000- by 4,000-foot model cells that receive water-table recharge and tracked using forward particle-tracking analysis modeling software to outflow zones. For each particle, simulated travel times were grouped by age as follows: less than or equal to 10 years, greater than 10 years and less than or equal to 100 years, greater than 100 years and less than or equal to 1,000 years, and greater than 1,000 years; and simulated ending zones were grouped into 48 receiving water bodies, based on the New York State Department of Environmental Conservation Waterbody Inventory/Priority Waterbodies List. Areal delineation of travel time zones and groundwater contributing areas were generated and a table was prepared presenting the sum of groundwater outflow for each area.

24 CFR 570.421 - New York Small Cities Program design.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true New York Small Cities Program design... HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES COMMUNITY DEVELOPMENT BLOCK GRANTS Small Cities, Non-Entitlement CDBG Grants in Hawaii and Insular Areas Programs § 570.421 New York Small Cities Program design...

The neurofibromatoses. Part 2: NF2 and schwannomatosis.

PubMed

Lu-Emerson, Christine; Plotkin, Scott R

2009-01-01

The neurofibromatoses, including neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), and schwannomatosis, comprise a group of genetically distinct disorders of the nervous system that are unified by the predisposition to nerve sheath tumors. All 3 types of NF have tumor manifestations (consistent with tumor-suppressor status) and nontumor manifestations. In the second part of this 2-part series, the manifestations of NF2 and schwannomatosis are reviewed. NF2 is characterized by bilateral vestibular schwannomas, meningiomas, ependymomas, cataracts, and epiretinal membranes. The combination of complete hearing loss from vestibular schwannomas and blindness from bifacial weakness is a devastating potential outcome of NF2. Schwannomatosis is characterized by multiple nonvestibular, nonintradermal schwannomas and chronic pain. Recently, germline alterations in the SMARCB1/INI1 gene have been implicated in both familial and sporadic forms of this disorder. Neurologists play an important role in the diagnosis and management of the neurofibromatoses.

CTF Meeting 2012: Translation of the Basic Understanding of the Biology and Genetics of NF1, NF2, and Schwannomatosis Toward the Development of Effective Therapies

PubMed Central

Widemann, Brigitte C.; Acosta, Maria T.; Ammoun, Sylvia; Belzberg, Allan J.; Bernards, Andre; Blakeley, Jaishri; Bretscher, Antony; Cichowski, Karen; Clapp, D. Wade; Dombi, Eva; Evans, Gareth D.; Ferner, Rosalie; Fernandez-Valle, Cristina; Fisher, Michael J.; Giovannini, Marco; Gutmann, David H.; Hanemann, C. Oliver; Hennigan, Robert; Huson, Susan; Ingram, David; Kissil, Joe; Korf, Bruce R.; Legius, Eric; Packer, Roger J.; McClatchey, Andrea I; McCormick, Frank; North, Kathryn; Pehrsson, Minja; Plotkin, Scott R.; Ramesh, Vijaya; Ratner, Nancy; Schirmer, Susann; Sherman, Larry; Schorry, Elizabeth; Stevenson, David; Stewart, Douglas R.; Ullrich, Nicole; Bakker, Annette C.; Morrison, Helen

2014-01-01

The neurofibromatoses (NF) are autosomal dominant genetic disorders that encompass the rare diseases NF1, NF2, and schwannomatosis. The NFs affect more people worldwide than Duchenne muscular dystrophy and Huntington's disease combined. NF1 and NF2 are caused by mutations of known tumor suppressor genes (NF1 and NF2, respectively). For schwannomatosis, although mutations in SMARCB1 were identified in a subpopulation of schwannomatosis patients, additional causative gene mutations are still to be discovered. Individuals with NF1 may demonstrate manifestations in multiple organ systems, including tumors of the nervous system, learning disabilities, and physical disfigurement. NF2 ultimately can cause deafness, cranial nerve deficits, and additional severe morbidities caused by tumors of the nervous system. Unmanageable pain is a key finding in patients with schwannomatosis. Although today there is no marketed treatment for NF-related tumors, a significant number of clinical trials have become available. In addition, significant preclinical efforts have led to a more rational selection of potential drug candidates for NF trials. An important element in fueling this progress is the sharing of knowledge. For over 20 years the Children's Tumor Foundation has convened an annual NF Conference, bringing together NF professionals to share novel findings, ideas, and build collaborations. The 2012 NF Conference held in New Orleans hosted over 350 NF researchers and clinicians. This article provides a synthesis of the highlights presented at the conference and as such, is a “state-of-the-field” for NF research in 2012. PMID:24443315

CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies.

PubMed

Widemann, Brigitte C; Acosta, Maria T; Ammoun, Sylvia; Belzberg, Allan J; Bernards, Andre; Blakeley, Jaishri; Bretscher, Antony; Cichowski, Karen; Clapp, D Wade; Dombi, Eva; Evans, Gareth D; Ferner, Rosalie; Fernandez-Valle, Cristina; Fisher, Michael J; Giovannini, Marco; Gutmann, David H; Hanemann, C Oliver; Hennigan, Robert; Huson, Susan; Ingram, David; Kissil, Joe; Korf, Bruce R; Legius, Eric; Packer, Roger J; McClatchey, Andrea I; McCormick, Frank; North, Kathryn; Pehrsson, Minja; Plotkin, Scott R; Ramesh, Vijaya; Ratner, Nancy; Schirmer, Susann; Sherman, Larry; Schorry, Elizabeth; Stevenson, David; Stewart, Douglas R; Ullrich, Nicole; Bakker, Annette C; Morrison, Helen

2014-03-01

The neurofibromatoses (NF) are autosomal dominant genetic disorders that encompass the rare diseases NF1, NF2, and schwannomatosis. The NFs affect more people worldwide than Duchenne muscular dystrophy and Huntington's disease combined. NF1 and NF2 are caused by mutations of known tumor suppressor genes (NF1 and NF2, respectively). For schwannomatosis, although mutations in SMARCB1 were identified in a subpopulation of schwannomatosis patients, additional causative gene mutations are still to be discovered. Individuals with NF1 may demonstrate manifestations in multiple organ systems, including tumors of the nervous system, learning disabilities, and physical disfigurement. NF2 ultimately can cause deafness, cranial nerve deficits, and additional severe morbidities caused by tumors of the nervous system. Unmanageable pain is a key finding in patients with schwannomatosis. Although today there is no marketed treatment for NF-related tumors, a significant number of clinical trials have become available. In addition, significant preclinical efforts have led to a more rational selection of potential drug candidates for NF trials. An important element in fueling this progress is the sharing of knowledge. For over 20 years the Children's Tumor Foundation has convened an annual NF Conference, bringing together NF professionals to share novel findings, ideas, and build collaborations. The 2012 NF Conference held in New Orleans hosted over 350 NF researchers and clinicians. This article provides a synthesis of the highlights presented at the conference and as such, is a "state-of-the-field" for NF research in 2012. © 2014 Wiley Periodicals, Inc.

NF-κB mediates Gadd45β expression and DNA demethylation in the hippocampus during fear memory formation.

PubMed

Jarome, Timothy J; Butler, Anderson A; Nichols, Jessica N; Pacheco, Natasha L; Lubin, Farah D

2015-01-01

Gadd45-mediated DNA demethylation mechanisms have been implicated in the process of memory formation. However, the transcriptional mechanisms involved in the regulation of Gadd45 gene expression during memory formation remain unexplored. NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) controls transcription of genes in neurons and is a critical regulator of synaptic plasticity and memory formation. In silico analysis revealed several NF-κB (p65/RelA and cRel) consensus sequences within the Gadd45β gene promoter. Whether NF-κB activity regulates Gadd45 expression and associated DNA demethylation in neurons during memory formation is unknown. Here, we found that learning in a fear conditioning paradigm increased Gadd45β gene expression and brain-derivedneurotrophic factor (BDNF) DNA demethylation in area CA1 of the hippocampus, both of which were prevented with pharmacological inhibition of NF-κB activity. Further experiments found that conditional mutations in p65/RelA impaired fear memory formation but did not alter changes in Gadd45β expression. The learning-induced increases in Gadd45β mRNA levels, Gadd45β binding at the BDNF gene and BDNF DNA demethylation were blocked in area CA1 of the c-rel knockout mice. Additionally, local siRNA-mediated knockdown of c-rel in area CA1 prevented fear conditioning-induced increases in Gadd45β expression and BDNF DNA demethylation, suggesting that c-Rel containing NF-κB transcription factor complex is responsible for Gadd45β regulation during memory formation. Together, these results support a novel transcriptional role for NF-κB in regulation of Gadd45β expression and DNA demethylation in hippocampal neurons during fear memory.

Tubular Epithelial NF-κB Activity Regulates Ischemic AKI

PubMed Central

Vigolo, Emilia; Hinze, Christian; Park, Joon-Keun; Roël, Giulietta; Balogh, András; Choi, Mira; Wübken, Anne; Cording, Jimmi; Blasig, Ingolf E.; Luft, Friedrich C.; Scheidereit, Claus; Schmidt-Ott, Kai M.; Schmidt-Ullrich, Ruth; Müller, Dominik N.

2016-01-01

NF-κB is a key regulator of innate and adaptive immunity and is implicated in the pathogenesis of AKI. The cell type–specific functions of NF-κB in the kidney are unknown; however, the pathway serves distinct functions in immune and tissue parenchymal cells. We analyzed tubular epithelial-specific NF-κB signaling in a mouse model of ischemia-reperfusion injury (IRI)–induced AKI. NF-κB reporter activity and nuclear localization of phosphorylated NF-κB subunit p65 analyses in mice revealed that IRI induced widespread NF-κB activation in renal tubular epithelia and in interstitial cells that peaked 2–3 days after injury. To genetically antagonize tubular epithelial NF-κB activity, we generated mice expressing the human NF-κB super-repressor IκBαΔN in renal proximal, distal, and collecting duct epithelial cells. Compared with control mice, these mice exhibited improved renal function, reduced tubular apoptosis, and attenuated neutrophil and macrophage infiltration after IRI-induced AKI. Furthermore, tubular NF-κB–dependent gene expression profiles revealed temporally distinct functional gene clusters for apoptosis, chemotaxis, and morphogenesis. Primary proximal tubular cells isolated from IκBαΔN-expressing mice and exposed to hypoxia-mimetic agent cobalt chloride exhibited less apoptosis and expressed lower levels of chemokines than cells from control mice did. Our results indicate that postischemic NF-κB activation in renal tubular epithelia aggravates tubular injury and exacerbates a maladaptive inflammatory response. PMID:26823548

48 CFR 810.002 - Market research procedures.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Market research procedures. 810.002 Section 810.002 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS COMPETITION AND ACQUISITION PLANNING MARKET RESEARCH 810.002 Market research procedures. Contracting officers...

48 CFR 810.002 - Market research procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Market research procedures. 810.002 Section 810.002 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS COMPETITION AND ACQUISITION PLANNING MARKET RESEARCH 810.002 Market research procedures. Contracting officers...

48 CFR 810.002 - Market research procedures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Market research procedures. 810.002 Section 810.002 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS COMPETITION AND ACQUISITION PLANNING MARKET RESEARCH 810.002 Market research procedures. Contracting officers...

48 CFR 810.002 - Market research procedures.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Market research procedures. 810.002 Section 810.002 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS COMPETITION AND ACQUISITION PLANNING MARKET RESEARCH 810.002 Market research procedures. Contracting officers...

Density of tobacco retailers and its association with sociodemographic characteristics of communities across New York.

PubMed

Loomis, B R; Kim, A E; Goetz, J L; Juster, H R

2013-04-01

To examine the association of community median income, race/ethnicity and age with the availability of tobacco products in New York State and six subareas. Spatial regression analysis applied to licensed tobacco retailer and sociodemographic data in 2009 in New York. This study assessed the association between tobacco retailer density and four demographic correlates (percentage African American, percentage Hispanic, percentage aged <18 years and median household income) at the census tract level in New York in 2009. Associations were modelled for New York State and six subareas: Greater New York City/Long Island, New York minus Greater New York City/Long Island (rest of State), the Capital region (containing the city of Albany and surrounding areas), Erie County (containing the city of Buffalo), Monroe County (containing the city of Rochester) and Onondaga County (containing the city of Syracuse). In total, 19,420 licensed tobacco retailers were linked to 4795 residential census tracts. In New York State, residential census tracts with higher proportions of African Americans and Hispanics generally had a significantly higher density of tobacco retailers. Census tracts with a higher percentage of residents aged <18 years and higher median household income generally had a significantly lower density of tobacco retailers. However, these associations were not statistically significant in all areas studied. Tobacco retailers tend to be more densely distributed in areas characterized by high minority or low-income populations, but these associations were not found in all areas. This may suggest that policy measures to reduce the density of tobacco retailers may be more effective at reducing disparities in tobacco availability and exposure to point-of-sale advertising in some areas than in others. Copyright © 2013 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

Dependency on Soup Kitchens in Urban Areas of New York State.

ERIC Educational Resources Information Center

Rauschenbach, Barbara S.; And Others

1990-01-01

A study of the dependency of persons on soup kitchens in Albany, Buffalo, Rochester, Syracuse, and Westchester County (New York) identified who uses these kitchens, the extent to which they are dependent on them, what other food programs they use, what their perceived need from other services is, and dependency differences of subgroups. (JS)

NF-κB and the link between inflammation and cancer.

PubMed

DiDonato, Joseph A; Mercurio, Frank; Karin, Michael

2012-03-01

The nuclear factor-κB (NF-κB) transcription factor family has been considered the central mediator of the inflammatory process and a key participant in innate and adaptive immune responses. Coincident with the molecular cloning of NF-κB/RelA and identification of its kinship to the v-Rel oncogene, it was anticipated that NF-κB itself would be involved in cancer development. Oncogenic activating mutations in NF-κB genes are rare and have been identified only in some lymphoid malignancies, while most NF-κB activating mutations in lymphoid malignancies occur in upstream signaling components that feed into NF-κB. NF-κB activation is also prevalent in carcinomas, in which NF-κB activation is mainly driven by inflammatory cytokines within the tumor microenvironment. Importantly, however, in all malignancies, NF-κB acts in a cell type-specific manner: activating survival genes within cancer cells and inflammation-promoting genes in components of the tumor microenvironment. Yet, the complex biological functions of NF-κB have made its therapeutic targeting a challenge. © 2012 John Wiley & Sons A/S.

Adsorption of pharmaceuticals onto isolated polyamide active layer of NF/RO membranes.

PubMed

Liu, Yan-Ling; Wang, Xiao-Mao; Yang, Hong-Wei; Xie, Yuefeng F

2018-06-01

Adsorption of trace organic compounds (TrOCs) onto the membrane materials has a great impact on their rejection by nanofiltration (NF) and reverse osmosis (RO) membranes. This study aimed to investigate the difference in adsorption of various pharmaceuticals (PhACs) onto different NF/RO membranes and to demonstrate the necessity of isolating the polyamide (PA) active layer from the polysulfone (PS) support layer for adsorption characterization and quantification. Both the isolated PA layers and the PA+PS layers of NF90 and ESPA1 membranes were used to conduct static adsorption tests. Results showed that apparent differences existed between the PA layer and the PA+PS layer in the adsorption capacity of PhACs as well as the time necessary to reach the adsorption equilibrium. PhACs with different physicochemical properties could be adsorbed to different extents by the isolated PA layer, which was mainly attributed to electrostatic attraction/repulsion and hydrophobic interactions. The PA layer of ESPA1 exhibited apparently higher adsorption capacities for the positively charged PhACs and similar adsorption capacities for the neutral PhACs although it had significantly less total interfacial area (per unit membrane surface area) for adsorption compared to the PA layer of NF90. The higher affinity of the PA layer of ESPA1 for the PhACs could be due to its higher capacity of forming hydrogen bonds with PhACs resulted from the modified chemistry with more -OH groups. This study provides a novel approach to determining the TrOC adsorption onto the active layer of membranes for the ease of investigating adsorption mechanisms. Copyright © 2018 Elsevier Ltd. All rights reserved.

Proteomic Analyses of NF1-Interacting Proteins in Keratinocytes

DTIC Science & Technology

2015-04-01

and knockout mice further confirmed the interactions suggested by the proteomic analyses. In relation to the development of psoriasis -like symptoms...in the NF1 null epidermis, we analyzed NF1 expression in a mouse model of psoriasis (imiquimod-induced psoriasis -like skin inflammation) and...knockout of epidermal NF1 to elucidate the molecular underpinnings of psoriasis . 15. SUBJECT TERMS neurofibromin-1 (NF1), psoriasis , inflammation

Hazardous Waste Cleanup: Realco Incorporated in Watervliet, New York

EPA Pesticide Factsheets

RealCo, Inc., formerly known as AL Tech Specialty Steel, consists of a main plant area (70 acres) and a waste management area (50 acres). The site is located at Spring Street Road in Watervliet, New York. The main plant area is bordered by the Kromma Kill

Angiogenesis and Therapeutic Approaches to NF1 Tumors

DTIC Science & Technology

2007-04-01

corneal neovascularization model was developed. In this model, the avascularity of the cornea highly facilitates the quantification of neovascularture...wild-type corneas in avascular area. However, in the NV zone, the number of macrophage was 4.6-fold greater in Nf1þ /– corneas than wild-type corneas...GEM tumor classification because of low cellularity and no necrosis . They exceed that clas- sification, however, due to their low to moderate prolif

Identification and characterization of NF-YB family genes in tung tree.

PubMed

Yang, Susu; Wang, Yangdong; Yin, Hengfu; Guo, Haobo; Gao, Ming; Zhu, Huiping; Chen, Yicun

2015-12-01

The NF-YB transcription factor gene family encodes a subunit of the CCAAT box-binding factor (CBF), a highly conserved trimeric activator that strongly binds to the CCAAT box promoter element. Studies on model plants have shown that NF-YB proteins participate in important developmental and physiological processes, but little is known about NF-YB proteins in trees. Here, we identified seven NF-YB transcription factor-encoding genes in Vernicia fordii, an important oilseed tree in China. A phylogenetic analysis separated the genes into two groups; non-LEC1 type (VfNF-YB1, 5, 7, 9, 11, 13) and LEC1-type (VfNF-YB 14). A gene structure analysis showed that VfNF-YB 5 has three introns and the other genes have no introns. The seven VfNF-YB sequences contain highly conserved domains, a disordered region at the N terminus, and two long helix structures at the C terminus. Phylogenetic analyses showed that VfNF-YB family genes are highly homologous to GmNF-YB genes, and many of them are closely related to functionally characterized NF-YBs. In expression analyses of various tissues (root, stem, leaf, and kernel) and the root during pathogen infection, VfNF-YB1, 5, and 11 were dominantly expressed in kernels, and VfNF-YB7 and 9 were expressed only in the root. Different VfNF-YB family genes showed different responses to pathogen infection, suggesting that they play different roles in the pathogen response. Together, these findings represent the first extensive evaluation of the NF-YB family in tung tree and provide a foundation for dissecting the functions of VfNF-YB genes in seed development, stress adaption, fatty acid synthesis, and pathogen response.

33 CFR 165.T01-0176 - Regulated Navigation Area; Lake Champlain Bridge Construction, Crown Point, New York and Chimney...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Champlain Bridge Construction, Crown Point, New York and Chimney Point, Vermont. 165.T01-0176 Section 165...; Lake Champlain Bridge Construction, Crown Point, New York and Chimney Point, Vermont. (a) Description... and south of the Lake Champlain Bridge construction zone at Crown Point, New York and Chimney Point...

46 CFR 163.002-7 - Independent laboratory.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 6 2010-10-01 2010-10-01 false Independent laboratory. 163.002-7 Section 163.002-7...: SPECIFICATIONS AND APPROVAL CONSTRUCTION Pilot Hoist § 163.002-7 Independent laboratory. (a) The approval and production tests in this subpart must be conducted by, or under the supervision of, an independent laboratory...

46 CFR 163.002-7 - Independent laboratory.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 6 2011-10-01 2011-10-01 false Independent laboratory. 163.002-7 Section 163.002-7...: SPECIFICATIONS AND APPROVAL CONSTRUCTION Pilot Hoist § 163.002-7 Independent laboratory. (a) The approval and production tests in this subpart must be conducted by, or under the supervision of, an independent laboratory...

Genomic organization of the neurofibromatosis 1 gene (NF1)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Y.; O`Connell, P.; Huntsman Breidenbach, H.

Neurofibromatosis 1 maps to chromosome band 17q11.2, and the NF1 locus has been partially characterized. Even though the full-length NF1 cDNA has been sequenced, the complete genomic structure of the NF1 gene has not been elucidated. The 5{prime} end of NF1 is embedded in a CpG island containing a NotI restriction site, and the remainder of the gene lies in the adjacent 350-kb NotI fragment. In our efforts to develop a comprehensive screen for NF1 mutations, we have isolated genomic DNA clones that together harbor the entire NF1 cDNA sequence. We have identified all intron-exon boundaries of the coding regionmore » and established that it is composed of 59 exons. Furthermore, we have defined the 3{prime}-untranslated region (3{prime}-UTR) of the NF1 gene; it spans approximately 3.5 kb of genomic DNA sequence and is continuous with the stop codon. Oligonucleotide primer pairs synthesized from exon-flanking DNA sequences were used in the polymerase chain reaction with cloned, chromosome 17-specific genomic DNA as template to amplify NF1 exons 1 through 27b and the exon containing the 3{prime}-UTR separately. This information should be useful for implementing a comprehensive NF1 mutation screen using genomic DNA as template. 41 refs., 3 figs., 2 tabs.« less

NF-kappaB: Two Sides of the Same Coin.

PubMed

Pires, Bruno R B; Silva, Rafael C M C; Ferreira, Gerson M; Abdelhay, Eliana

2018-01-09

Nuclear Factor-kappa B (NF-κB) is a transcription factor family that regulates a large number of genes that are involved in important physiological processes, including survival, inflammation, and immune responses. More recently, constitutive expression of NF-κB has been associated with several types of cancer. In addition, microorganisms, such as viruses and bacteria, cooperate in the activation of NF-κB in tumors, confirming the multifactorial role of this transcription factor as a cancer driver. Recent reports have shown that the NF-κB signaling pathway should receive attention for the development of therapies. In addition to the direct effects of NF-κB in cancer cells, it might also impact immune cells that can both promote or prevent tumor development. Currently, with the rise of cancer immunotherapy, the link among immune cells, inflammation, and cancer is a major focus, and NF-κB could be an important regulator for the success of these therapies. This review discusses the contrasting roles of NF-κB as a regulator of pro- and antitumor processes and its potential as a therapeutic target.

A Chinese 2-herb formula (NF3) promotes hindlimb ischemia-induced neovascularization and wound healing of diabetic rats.

PubMed

Tam, Jacqueline Chor-Wing; Ko, Chun-Hay; Lau, Kit-Man; To, Ming-Ho; Kwok, Hin-Fai; Chan, Yuet-Wa; Siu, Wing-Sum; Etienne-Selloum, Nelly; Lau, Ching-Po; Chan, Wai-Yee; Leung, Ping-Chung; Fung, Kwok-Pui; Schini-Kerth, Valérie B; Lau, Clara Bik-San

2014-01-01

Diabetic foot ulcer is closely associated with peripheral vascular disease. Enhancement of tissue oxidative stress, reduction of nitric oxide (NO) and angiogenic growth factors, and abnormal matrix metalloproteinase (MMP) activity are pathophysiological factors in post-ischemic neovascularization and diabetic wound healing. Our previous study demonstrated that the Chinese 2-herb formula, NF3, showed significant wound healing effects on diabetic foot ulcer rats. A novel rat diabetic foot ulcer with hindlimb ischemia model was established in order to strengthen our claims on the diabetic wound healing and post-ischemic neovascularization effects of NF3. Our results demonstrate that NF3 can significantly reduce the wound area of the diabetic foot ulcer rat with hindlimb ischemia by 21.6% (p<0.05) compared with the control group. In addition, flow cytometric analysis revealed that NF3 could boost circulating EPC levels for local wound vessel incorporation. Immunohistochemical analysis showed that NF3 could significantly augment blood vessel density, VEGF and eNOS expression, and attenuate tissue oxidative stress of ischemic muscles (p<0.001). NF3 significantly stimulated MMP activity involved in angiogenesis. Our study shows, for the first time, the beneficial effects of NF3 in wound healing and post-ischemic neovascularization in diabetes. Copyright © 2014 Elsevier Inc. All rights reserved.

Steroid Hormones in NF1 Tumorigenesis

DTIC Science & Technology

2005-08-01

Schwannomatosis , in Aspen in June this year. Table 3. Summary of current xenograft proliferation/TUNEL (apoptosis) data. Culture I sex I Outlier? I PI/Al I...Biology of NF1, NF2, and schwannomatosis . Aspen, CO, June 2005, poster. CONCLUSIONS: In vitro data indicate that steroid hormone receptor levels in normal

Central New York's New Workforce

ERIC Educational Resources Information Center

Center for an Urban Future, 2009

2009-01-01

Conducted in late 2008 in partnership with the Greater Syracuse Chamber of Commerce and the Mohawk Valley Chamber of Commerce, this is the largest survey ever taken of Central New York businesses regarding the English language skills of the area workforce. The online survey was emailed to several hundred local businesses; 126 responses were…

NF90–NF45 is a selective RNA chaperone that rearranges viral and cellular riboswitches: biochemical analysis of a virus host factor activity

PubMed Central

Friedrich, Susann; Golbik, Ralph Peter

2017-01-01

Abstract The heterodimer NF90–NF45 is an RNA-binding protein complex that modulates the expression of various cellular mRNAs on the post-transcriptional level. Furthermore, it acts as a host factor that supports the replication of several RNA viruses. The molecular mechanisms underlying these activities have yet to be elucidated. Recently, we showed that the RNA-binding capabilities and binding specificity of NF90 considerably improves when it forms a complex with NF45. Here, we demonstrate that NF90 has a substrate-selective RNA chaperone activity (RCA) involving RNA annealing and strand displacement activities. The mechanism of the NF90-catalyzed RNA annealing was elucidated to comprise a combination of ‘matchmaking’ and compensation of repulsive charges, which finally results in the population of dsRNA products. Heterodimer formation with NF45 enhances ‘matchmaking’ of complementary ssRNAs and substantially increases the efficiency of NF90’s RCA. During investigations of the relevance of the NF90–NF45 RCA, the complex was shown to stimulate the first step in the RNA replication process of hepatitis C virus (HCV) in vitro and to stabilize a regulatory element within the mRNA of vascular endothelial growth factor (VEGF) by protein-guided changes of the RNAs’ structures. Thus, our study reveals how the intrinsic properties of an RNA-binding protein determine its biological activities. PMID:29040738

46 CFR 163.002-21 - Approval tests.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 6 2014-10-01 2014-10-01 false Approval tests. 163.002-21 Section 163.002-21 Shipping...: SPECIFICATIONS AND APPROVAL CONSTRUCTION Pilot Hoist § 163.002-21 Approval tests. (a) General. If a pilot hoist fails one of the tests in this section the cause of the failure must be identified and any needed design...

Has New York City fallen into the local trap?

PubMed

Libman, Kimberly

2015-04-01

Municipal policies aiming to improve equity in food access and health often rely on the assumption that neighborhoods with limited healthy food availability and high levels of diet-related illness should be the subject of targeted policy-driven change. This study explored this assumption in the context of recent food policy developments in New York City with the objective of empirically examining the geography of everyday food behavior in high- and low-income neighborhoods. This research used a multi method comparative design. Areas at the poles of income inequality in New York City were identified using census data and geographic information systems. Qualitative and geographic data were collected from individual eaters living and/or working in those areas. A review of food policies in New York City from 2005 to 2012. Qualitative and geographic data were collected using space-time food diaries and mental mapping interviews. People living in the low-income study area had more localized food geographies than residents of the high-income study area. Individual-level qualitative data revealed that eaters with the least financial resources, those with physical disabilities, and those who were unemployed reported all or nearly all of their food events taking place within their neighborhoods. Eaters from the low-income area suggested that the barriers to healthy food that policy incentives should address were the high price of food and the consumer environment within stores, not the number of supermarkets in their area. Residents of the high-income area also expressed dissatisfaction with food prices and the in-store environment of their local supermarkets. These eaters leveraged their financial, technological, and transportation resources to overcome those barriers to fresh food. The policy review found that New York City's recent nutrition and food policies are to a great extent geographically targeted to low-income areas. As such, they miss opportunities for citywide

Clinical features of human salmonellosis caused by bovine-associated subtypes in New York.

PubMed

Cummings, Kevin J; Warnick, Lorin D; Gröhn, Yrjö T; Hoelzer, Karin; Root, Timothy P; Siler, Julie D; McGuire, Suzanne M; Wright, Emily M; Zansky, Shelley M; Wiedmann, Martin

2012-09-01

The objective of this study was to identify patient symptoms and case outcomes that were more likely to occur as a result of Salmonella infections caused by bovine-associated subtypes (isolates that matched contemporary bovine isolates from New York by serovar and pulsed-field gel electrophoresis pattern), as compared to salmonellosis caused by non-bovine-associated subtypes. Data were collected in 34 counties of New York that comprise the Foodborne Diseases Active Surveillance Network (FoodNet) catchment area of the Centers for Disease Control and Prevention Emerging Infections Program. Patients with specimen collection dates between March 1, 2008 and March 1, 2010 were included. Symptoms and outcomes of 40 cases infected with bovine-associated Salmonella subtypes were compared to those of 379 control-cases infected with Salmonella isolates that were not bovine-associated. Cases were significantly more likely to have invasive salmonellosis (odds ratio, 3.8; p-value=0.02), after adjusting for age group, gender, and race. In addition, there was a marginal association between case status and the presence of blood in the stool (p-value=0.1) while ill. These findings might have implications for patient management, as a history of consuming undercooked foods of bovine origin or having direct contact with cattle in the few days prior to illness could be useful for suggesting a more proactive diagnostic approach as well as close monitoring for the need to implement more aggressive therapy.

Clinical Features of Human Salmonellosis Caused by Bovine-Associated Subtypes in New York

PubMed Central

Warnick, Lorin D.; Gröhn, Yrjö T.; Hoelzer, Karin; Root, Timothy P.; Siler, Julie D.; McGuire, Suzanne M.; Wright, Emily M.; Zansky, Shelley M.; Wiedmann, Martin

2012-01-01

Abstract The objective of this study was to identify patient symptoms and case outcomes that were more likely to occur as a result of Salmonella infections caused by bovine-associated subtypes (isolates that matched contemporary bovine isolates from New York by serovar and pulsed-field gel electrophoresis pattern), as compared to salmonellosis caused by non-bovine-associated subtypes. Data were collected in 34 counties of New York that comprise the Foodborne Diseases Active Surveillance Network (FoodNet) catchment area of the Centers for Disease Control and Prevention Emerging Infections Program. Patients with specimen collection dates between March 1, 2008 and March 1, 2010 were included. Symptoms and outcomes of 40 cases infected with bovine-associated Salmonella subtypes were compared to those of 379 control-cases infected with Salmonella isolates that were not bovine-associated. Cases were significantly more likely to have invasive salmonellosis (odds ratio, 3.8; p-value=0.02), after adjusting for age group, gender, and race. In addition, there was a marginal association between case status and the presence of blood in the stool (p-value=0.1) while ill. These findings might have implications for patient management, as a history of consuming undercooked foods of bovine origin or having direct contact with cattle in the few days prior to illness could be useful for suggesting a more proactive diagnostic approach as well as close monitoring for the need to implement more aggressive therapy. PMID:22870888

41 CFR 101-39.002 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Applicability. 101-39.002 Section 101-39.002 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET...

Chemical Production of Excited NF.

DTIC Science & Technology

1982-07-01

purpose other than in connection with a definitely Government -related procure - ment, the United States Government incurs no responsibility or any...AD- AIIB 017 ROCKWELL INTERNATIONAL THOUSAND OAKS CA SCIENCE CENTER F/S -7/NF CHEMICAL PRODUC TION OF E XC ITED NF( U ) JUL 82 R D COOMBE , fl PATEL...Captain Ernest Kunstadt (ARAP) was the Laboratory Project Officer-in-Charge. When Government drawings, specifications, or other data are used for any

Hazardous Waste Cleanup: Revere Smelting and Refining Corporation in Middletown, New York

EPA Pesticide Factsheets

Revere Smelting and Refining Corporation operates a secondary lead smelter at 65 Ballard Road in Middletown, New York. The site is located in a rural area of southeastern New York and consists of approximately 61 acre of land, one third of which is used

Assessing coastal flood risk and sea level rise impacts at New York City area airports

NASA Astrophysics Data System (ADS)

Ohman, K. A.; Kimball, N.; Osler, M.; Eberbach, S.

2014-12-01

Flood risk and sea level rise impacts were assessed for the Port Authority of New York and New Jersey (PANYNJ) at four airports in the New York City area. These airports included John F. Kennedy International, LaGuardia, Newark International, and Teterboro Airports. Quantifying both present day and future flood risk due to climate change and developing flood mitigation alternatives is crucial for the continued operation of these airports. During Hurricane Sandy in October 2012 all four airports were forced to shut down, in part due to coastal flooding. Future climate change and sea level rise effects may result in more frequent shutdowns and disruptions in travel to and from these busy airports. The study examined the effects of the 1%-annual-chance coastal flooding event for present day existing conditions and six different sea level rise scenarios at each airport. Storm surge model outputs from the Federal Emergency Management Agency (FEMA) provided the present day storm surge conditions. 50th and 90thpercentile sea level rise projections from the New York Panel on Climate Change (NPCC) 2013 report were incorporated into storm surge results using linear superposition methods. These projections were evaluated for future years 2025, 2035, and 2055. In addition to the linear superposition approach for storm surge at airports where waves are a potential hazard, one dimensional wave modeling was performed to get the total water level results. Flood hazard and flood depth maps were created based on these results. In addition to assessing overall flooding at each airport, major at-risk infrastructure critical to the continued operation of the airport was identified and a detailed flood vulnerability assessment was performed. This assessment quantified flood impacts in terms of potential critical infrastructure inundation and developed mitigation alternatives to adapt to coastal flooding and future sea level changes. Results from this project are advancing the PANYNJ

Genome-wide characterization and expression analysis of citrus NUCLEAR FACTOR-Y (NF-Y) transcription factors identified a novel NF-YA gene involved in drought-stress response and tolerance.

PubMed

Pereira, Suzam L S; Martins, Cristina P S; Sousa, Aurizangela O; Camillo, Luciana R; Araújo, Caroline P; Alcantara, Grazielle M; Camargo, Danielle S; Cidade, Luciana C; de Almeida, Alex-Alan F; Costa, Marcio G C

2018-01-01

Nuclear factor Y (NF-Y) is a ubiquitous transcription factor found in eukaryotes. It is composed of three distinct subunits called NF-YA, NF-YB and NF-YC. NF-Ys have been identified as key regulators of multiple pathways in the control of development and tolerance to biotic and abiotic factors. The present study aimed to identify and characterize the complete repertoire of genes coding for NF-Y in citrus, as well as to perform the functional characterization of one of its members, namely CsNFYA5, in transgenic tobacco plants. A total of 22 genes coding for NF-Y were identified in the genomes of sweet orange (Citrus sinensis) and Clementine mandarin (C. clementina), including six CsNF-YAs, 11 CsNF-YBs and five CsNF-YCs. Phylogenetic analyses showed that there is a NF-Y orthologous in the Clementine genome for each sweet orange NF-Y gene; this was not observed when compared to Arabidopsis thaliana. CsNF-Y proteins shared the same conserved domains with their orthologous proteins in other organisms, including mouse. Analysis of gene expression by RNA-seq and EST data demonstrated that CsNF-Ys have a tissue-specific and stress inducible expression profile. qRT-PCR analysis revealed that CsNF-YA5 exhibits differential expression in response to water deficit in leaves and roots of citrus plants. Overexpression of CsNF-YA5 in transgenic tobacco plants contributed to the reduction of H2O2 production under dehydration conditions and increased plant growth and photosynthetic rate under normal conditions and drought stress. These biochemical and physiological responses to drought stress promoted by CsNF-YA5 may confer a productivity advantage in environments with frequent short-term soil water deficit.

33 CFR 165.163 - Safety Zones; Port of New York/New Jersey Fleet Week.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zones; Port of New York... § 165.163 Safety Zones; Port of New York/New Jersey Fleet Week. (a) The following areas are established... parade vessels as it transits the Port of New York and New Jersey from the Verrazano Narrows Bridge to...

Electron transport parameters in NF3

NASA Astrophysics Data System (ADS)

Lisovskiy, V.; Yegorenkov, V.; Ogloblina, P.; Booth, J.-P.; Martins, S.; Landry, K.; Douai, D.; Cassagne, V.

2014-03-01

We present electron transport parameters (the first Townsend coefficient, the dissociative attachment coefficient, the fraction of electron energy lost by collisions with NF3 molecules, the average and characteristic electron energy, the electron mobility and the drift velocity) in NF3 gas calculated from published elastic and inelastic electron-NF3 collision cross-sections using the BOLSIG+ code. Calculations were performed for the combined RB (Rescigno 1995 Phys. Rev. E 52 329, Boesten et al 1996 J. Phys. B: At. Mol. Opt. Phys. 29 5475) momentum-transfer cross-section, as well as for the JB (Joucoski and Bettega 2002 J. Phys. B: At. Mol. Opt. Phys. 35 783) momentum-transfer cross-section. In addition, we have measured the radio frequency (rf) breakdown curves for various inter-electrode gaps and rfs, and from these we have determined the electron drift velocity in NF3 from the location of the turning point in these curves. These drift velocity values are in satisfactory agreement with those calculated by the BOLSIG+ code employing the JB momentum-transfer cross-section.

Risk association between the NF-κB1 -94ins/delATTG promoter polymorphism and inflammatory bowel diseases: a meta-analysis.

PubMed

Liang, Meilan; Xu, Xinyu; Gong, Yaoyao; Tang, Yurong; Lin, Lin

2012-09-01

Extensive investigation of the NF-κB1 -94ins/delATTG promoter polymorphism for risk association with ulcerative colitis (UC) and Crohn's disease (CD) risk has yielded conflicting results. The objective of this meta-analysis was to evaluate the risk association between the NF-κB1 -94ins/delATTG promoter polymorphism and UC and CD. All eligible case-control studies of the association of NF-κB1 -94ins/delATTG promoter polymorphism with UC and CD were identified in the Pubmed and Embase databases. From these data, odds ratios (OR) with 95 % confidence intervals (CI) were calculated. Meta-analysis was performed for alleles (D vs. W) and genotypes (DD + WD vs. WW, DD vs. WW + WD, DD vs. WW, WD vs. WW) in a fixed/random effects model. Nine case-control studies that included 4,447 cases (2,631 UC and 1,816 CD) and 2,195 controls were identified. Results indicated increased risk association of D allele carriers with UC (D vs. W: OR = 1.08, 95 % CI = 1.01-1.17, P = 0.03; DD vs. WW + WD: OR = 1.16, 95 % CI = 1.01-1.32, P = 0.04 and DD vs. WW: OR = 1.20, 95 % CI = 1.03-1.39, P = 0.02). No risk association was identified with CD. This meta-analysis indicated that the NF-κB1 -94ins/delATTG promoter polymorphism is a risk factor for UC but not CD.

NF-kappaB: Two Sides of the Same Coin

PubMed Central

Silva, Rafael C. M. C.; Ferreira, Gerson M.; Abdelhay, Eliana

2018-01-01

Nuclear Factor-kappa B (NF-κB) is a transcription factor family that regulates a large number of genes that are involved in important physiological processes, including survival, inflammation, and immune responses. More recently, constitutive expression of NF-κB has been associated with several types of cancer. In addition, microorganisms, such as viruses and bacteria, cooperate in the activation of NF-κB in tumors, confirming the multifactorial role of this transcription factor as a cancer driver. Recent reports have shown that the NF-κB signaling pathway should receive attention for the development of therapies. In addition to the direct effects of NF-κB in cancer cells, it might also impact immune cells that can both promote or prevent tumor development. Currently, with the rise of cancer immunotherapy, the link among immune cells, inflammation, and cancer is a major focus, and NF-κB could be an important regulator for the success of these therapies. This review discusses the contrasting roles of NF-κB as a regulator of pro- and antitumor processes and its potential as a therapeutic target. PMID:29315242

Genotype-Phenotype Correlation in NF1: Evidence for a More Severe Phenotype Associated with Missense Mutations Affecting NF1 Codons 844-848.

PubMed

Koczkowska, Magdalena; Chen, Yunjia; Callens, Tom; Gomes, Alicia; Sharp, Angela; Johnson, Sherrell; Hsiao, Meng-Chang; Chen, Zhenbin; Balasubramanian, Meena; Barnett, Christopher P; Becker, Troy A; Ben-Shachar, Shay; Bertola, Debora R; Blakeley, Jaishri O; Burkitt-Wright, Emma M M; Callaway, Alison; Crenshaw, Melissa; Cunha, Karin S; Cunningham, Mitch; D'Agostino, Maria D; Dahan, Karin; De Luca, Alessandro; Destrée, Anne; Dhamija, Radhika; Eoli, Marica; Evans, D Gareth R; Galvin-Parton, Patricia; George-Abraham, Jaya K; Gripp, Karen W; Guevara-Campos, Jose; Hanchard, Neil A; Hernández-Chico, Concepcion; Immken, LaDonna; Janssens, Sandra; Jones, Kristi J; Keena, Beth A; Kochhar, Aaina; Liebelt, Jan; Martir-Negron, Arelis; Mahoney, Maurice J; Maystadt, Isabelle; McDougall, Carey; McEntagart, Meriel; Mendelsohn, Nancy; Miller, David T; Mortier, Geert; Morton, Jenny; Pappas, John; Plotkin, Scott R; Pond, Dinel; Rosenbaum, Kenneth; Rubin, Karol; Russell, Laura; Rutledge, Lane S; Saletti, Veronica; Schonberg, Rhonda; Schreiber, Allison; Seidel, Meredith; Siqveland, Elizabeth; Stockton, David W; Trevisson, Eva; Ullrich, Nicole J; Upadhyaya, Meena; van Minkelen, Rick; Verhelst, Helene; Wallace, Margaret R; Yap, Yoon-Sim; Zackai, Elaine; Zonana, Jonathan; Zurcher, Vickie; Claes, Kathleen; Martin, Yolanda; Korf, Bruce R; Legius, Eric; Messiaen, Ludwine M

2018-01-04

Neurofibromatosis type 1 (NF1), a common genetic disorder with a birth incidence of 1:2,000-3,000, is characterized by a highly variable clinical presentation. To date, only two clinically relevant intragenic genotype-phenotype correlations have been reported for NF1 missense mutations affecting p.Arg1809 and a single amino acid deletion p.Met922del. Both variants predispose to a distinct mild NF1 phenotype with neither externally visible cutaneous/plexiform neurofibromas nor other tumors. Here, we report 162 individuals (129 unrelated probands and 33 affected relatives) heterozygous for a constitutional missense mutation affecting one of five neighboring NF1 codons-Leu844, Cys845, Ala846, Leu847, and Gly848-located in the cysteine-serine-rich domain (CSRD). Collectively, these recurrent missense mutations affect ∼0.8% of unrelated NF1 mutation-positive probands in the University of Alabama at Birmingham (UAB) cohort. Major superficial plexiform neurofibromas and symptomatic spinal neurofibromas were more prevalent in these individuals compared with classic NF1-affected cohorts (both p < 0.0001). Nearly half of the individuals had symptomatic or asymptomatic optic pathway gliomas and/or skeletal abnormalities. Additionally, variants in this region seem to confer a high predisposition to develop malignancies compared with the general NF1-affected population (p = 0.0061). Our results demonstrate that these NF1 missense mutations, although located outside the GAP-related domain, may be an important risk factor for a severe presentation. A genotype-phenotype correlation at the NF1 region 844-848 exists and will be valuable in the management and genetic counseling of a significant number of individuals. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Regionalism and State University of New York, 1972-76.

ERIC Educational Resources Information Center

1977

The State University of New York comprises four formal coordinating areas for the development of regional contacts and interinstitutional and regional cooperation. The four coordinating areas have been operating since 1972 and the differing patterns of cooperation that have emerged are outlined as are the formal activities of each area. Only one…

NF1 Signal Transduction and Vascular Dysfunction

DTIC Science & Technology

2014-05-01

presence of the Cad5:ERT allele, the Rosa26 LSL- tomato reporter, a floxed NF1 allele and the presence of a NF1 mutant (deletion) allele. Green arrows indicate mouse pups positive for all 4 selected alleles. 23

NF-kappa B activation correlates with disease phenotype in Crohn’s disease

PubMed Central

Han, Yoo Min; Koh, Jaemoon; Lee, Changhyun; Koh, Seong-Joon; Kim, ByeongGwan; Lee, Kook Lae; Im, Jong Pil; Kim, Joo Sung

2017-01-01

Background/Aims Unregulated activation of nuclear factor-κB (NF-κB) plays a critical role in the pathogenesis of Crohn’s disease. In this study, we investigated the clinical characteristics and disease outcome of Crohn’s disease patients with varying levels of the NF-κB activation. Methods Crohn’s disease patients who underwent surgical bowel resection were divided into two groups, based on the activation status of NF-κB. NF-κB activation was assessed by the immunoreactivity of nuclear NF-κB during immunohistochemical staining of bowel resection specimens. We compared the demographic, clinical and histologic characteristics between groups. Furthermore, the occurrence of reoperation, readmission, and medication change due to disease flare-up were investigated according to NF-κB activation status. Results Among 83 Crohn’s disease patients, 47 (56%) showed high NF-κB activity and 36 (44%) showed low NF-κB activity. Patients with high NF-κB activity had higher frequency of ileocolonic involvement (P = 0.028) and lower frequency of perianal involvement (P = 0.042) relative to those with low NF-κB activity. Total histologic scores were significantly higher in patients with high NF-κB activity than those with low NF-κB activity (P = 0.044). There was no significant difference in the frequency of reoperation, readmission, and medication change in relation to NF-κB activation status. Conclusions Crohn’s disease patients with high NF-κB activation showed specific clinical manifestations of higher frequency of ileocolonic involvement and lower frequency of perianal involvement relative to those with low NF-κB activation. High NF-κB activity was associated with higher histologic scores. However, the NF-κB activity did not affect the outcome and disease course after surgery. PMID:28753650

Landslide susceptibility in the Tully Valley area, Finger Lakes region, New York

USGS Publications Warehouse

Jager, Stefan; Wieczorek, Gerald E.

1994-01-01

As a consequence of a large landslide in the Tully Valley, Onondaga County, New York, an investigation was undertaken to determine the factors responsible for the landslide in order to develop a model for regional landslide susceptibility. The April 27, 1993 Tully Valley landslide occurred within glacial lake clays overlain by till and colluvium on gentle slopes of 9-12 degrees. The landslide was triggered by extreme climatic events of prolonged heavy rainfall combined with rapid melting of a winter snowpack. A photoinventory and field checking of landslides within a 415 km2 study area, including the Tully Valley, revealed small recently-active landslides and other large dormant prehistoric landslides, probably Pleistocene in age. Similar to the larger Tully Valley landslide, the smaller recently-active landslides occurred in red, glacial lake clays very likely triggered by seasonal rainfall. The large dormant landslides have been stable for long periods as evidenced by slope denudational processes that have modified the landslides. These old and ancient landslides correspond with proglacial lake levels during the Pleistocene, suggesting that either inundation or rapid drainage was responsible for triggering these landslides. A logistic regression analysis was performed within a Geographic Information System (GIS) environment to develop a model of landslide susceptibility for the Tully Valley study area. Presence of glacial clays, slope angle, and glacial lake levels were used as explanatory variables for landslide incidence. The spatial probability of landsliding, categorized as low, moderate and high, is portrayed within 90-m square cells on the susceptibility map.

Multiscale, Converging Defects of Macro-Porosity, Microstructure and Matrix Mineralization Impact Long Bone Fragility in NF1

PubMed Central

Kühnisch, Jirko; Seto, Jong; Lange, Claudia; Schrof, Susanne; Stumpp, Sabine; Kobus, Karolina; Grohmann, Julia; Kossler, Nadine; Varga, Peter; Osswald, Monika; Emmerich, Denise; Tinschert, Sigrid; Thielemann, Falk; Duda, Georg; Seifert, Wenke; el Khassawna, Thaqif; Stevenson, David A.; Elefteriou, Florent; Kornak, Uwe; Raum, Kay; Fratzl, Peter; Mundlos, Stefan; Kolanczyk, Mateusz

2014-01-01

Bone fragility due to osteopenia, osteoporosis or debilitating focal skeletal dysplasias is a frequent observation in the Mendelian disease Neurofibromatosis type 1 (NF1). To determine the mechanisms underlying bone fragility in NF1 we analyzed two conditional mouse models, Nf1Prx1 (limb knock-out) and Nf1Col1 (osteoblast specific knock-out), as well as cortical bone samples from individuals with NF1. We examined mouse bone tissue with micro-computed tomography, qualitative and quantitative histology, mechanical tensile analysis, small-angle X-ray scattering (SAXS), energy dispersive X-ray spectroscopy (EDX), and scanning acoustic microscopy (SAM). In cortical bone of Nf1Prx1 mice we detected ectopic blood vessels that were associated with diaphyseal mineralization defects. Defective mineral binding in the proximity of blood vessels was most likely due to impaired bone collagen formation, as these areas were completely devoid of acidic matrix proteins and contained thin collagen fibers. Additionally, we found significantly reduced mechanical strength of the bone material, which was partially caused by increased osteocyte volume. Consistent with these observations, bone samples from individuals with NF1 and tibial dysplasia showed increased osteocyte lacuna volume. Reduced mechanical properties were associated with diminished matrix stiffness, as determined by SAM. In line with these observations, bone tissue from individuals with NF1 and tibial dysplasia showed heterogeneous mineralization and reduced collagen fiber thickness and packaging. Collectively, the data indicate that bone fragility in NF1 tibial dysplasia is partly due to an increased osteocyte-related micro-porosity, hypomineralization, a generalized defect of organic matrix formation, exacerbated in the regions of tensional and bending force integration, and finally persistence of ectopic blood vessels associated with localized macro-porotic bone lesions. PMID:24465906

NF45 inhibits cardiomyocyte apoptosis following myocardial ischemia-reperfusion injury.

PubMed

Liu, Xiaojuan; Zhang, Chi; Qian, Long; Zhang, Chao; Wu, Kunpeng; Yang, Chen; Yan, Daliang; Wu, Xiang; Shi, Jiahai

2015-12-01

Cardiomyocyte apoptosis, which occurs during ischemia and reperfusion injury, can cause irreversible damage to cardiac function. There is accumulating evidence that nuclear factor 45 (NF45) and regulatory pathways are important in understanding reparative processes in the myocardium. NF45 is a multifunctional regulator of gene expression that participates in the regulation of DNA break repair. Recently, NF45 has been proved to be associated with tumor cell apoptosis in various human malignancies. However, the underlying mechanism of NF45 regulating myocardial ischemia-reperfusion (I/R) injury remains unclear. In this study, western blot showed that NF45 expression decreased after myocardial I/R in vivo. Double immunofluorescent staining revealed that NF45, located in the nucleus of cardiomyocyes, was correlated with cardiomyocyte apoptosis. Furthermore, NF45 expression decreased in H9c2 cells after hypoxia-reoxygenation (H/R) treatment in vitro, which was in line with the results in vivo. Overexpression of NF45 in H9c2 cells reduced cell apoptosis, as evidenced by increased Bcl-2 level, as well as decreased cleaved caspase-3, p53 and p21 expression. The expression of NF45 was reduced by LY294002 (a PI3K/Akt inhibitor), but not SB203580 (a p38 inhibitor), suggesting that NF45 prevented H/R-induced H9c2 cell apoptosis via PI3K/Akt pathway. Our data may supply a novel molecular target for acute myocardial infarction (AMI) therapy. Copyright © 2015 Elsevier GmbH. All rights reserved.

Water resources of the Utica-Rome area, New York

USGS Publications Warehouse

Halberg, Henry N.; Hunt, O.P.; Pauszek, F.H.

1963-01-01

The Utica-Rome area is along the Mohawk River and New York State Erie (Barge) Canal about midway between Lake Ontario and Albany. It encompasses about 390 square miles centered around the industrial cities of Utica and Rome. The Mohawk River, its tributary West Canada Creek, and a system of reservoirs and diversions to maintain the flow in the barge-canal system, assure an ample water supply for the foreseeable needs of the area. The water from these sources is generally of good chemical quality requiring little treatment, although that from the Mohawk River is only fair and may require some treatment for sensitive industrial processes. Additional surface water is available from smaller streams in the area, particularly Oriskany and Sauquoit Creeks, but the water from these sources is hard, and has a dissolved-solids content of more than 250 ppm (parts per million). Ground water is available in moderate quantities from unconsolidated sand and gravel deposits in the river valleys and buried bedrock channels, and in small quantities from bedrock formations and less permeable unconsolidated deposits. The quality of water from sand and gravel, and bedrock ranges from good to poor. However, where necessary, the quality can be improved with treatment. The Mohawk River is the source of the largest quantity of water in the area. The flow of the stream below Delta Dam equals or exceeds 108 mgd (million gallons per day) 90 percent of the time, and at Little Falls it equals or exceeds 560 mgd 90 percent of the time. The flow between these two points is increased by additions from Oriskany, Sauquoit, and West Canada Creeks and from many smaller tributary streams. The flow is also increased by diversions from outside the area, from the Black and Chenango Rivers and West Canada Creek for improvement of navigation in the Erie (Barge) Canal, and from West Canada and East Branch Fish Creeks for the public supplies of Utica and Rome. Much of the public-supply water eventually

Winter storm intensity, hazards, and property losses in the New York tristate area.

PubMed

Shimkus, Cari E; Ting, Mingfang; Booth, James F; Adamo, Susana B; Madajewicz, Malgosia; Kushnir, Yochanan; Rieder, Harald E

2017-07-01

Winter storms pose numerous hazards to the Northeast United States, including rain, snow, strong wind, and flooding. These hazards can cause millions of dollars in damages from one storm alone. This study investigates meteorological intensity and impacts of winter storms from 2001 to 2014 on coastal counties in Connecticut, New Jersey, and New York and underscores the consequences of winter storms. The study selected 70 winter storms on the basis of station observations of surface wind strength, heavy precipitation, high storm tide, and snow extremes. Storm rankings differed between measures, suggesting that intensity is not easily defined with a single metric. Several storms fell into two or more categories (multiple-category storms). Following storm selection, property damages were examined to determine which types lead to high losses. The analysis of hazards (or events) and associated damages using the Storm Events Database of the National Centers for Environmental Information indicates that multiple-category storms were responsible for a greater portion of the damage. Flooding was responsible for the highest losses, but no discernible connection exists between the number of storms that afflict a county and the damage it faces. These results imply that losses may rely more on the incidence of specific hazards, infrastructure types, and property values, which vary throughout the region. © 2017 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals Inc. on behalf of The New York Academy of Sciences.

The Role of NF1 in Memory Retrieval

DTIC Science & Technology

2014-09-01

ABSTRACT This
three‐year
grant
supports
our
efforts
in
studying
a
role
of
the
 neurofibromatosis 
type
 1
(NF1)
gene
in
mediating
retrieval
of
long‐term...year extension. The proposed research investigates involvement of neurofibromatosis type 1 gene-encoded neurofibromin (NF1) in retrieval of long...mutations of this gene lead to the most common monogenic disorder, neurofibromatosis type 1. The critical role of NF1 in learning and memory has been

75 FR 45076 - Approval and Promulgation of Air Quality Implementation Plans; New York, New Jersey, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-02

... the 2007-2009 design value for the NY-NJ-CT PM 2.5 nonattainment area would be 14.0 [micro]g/m\\3\\. VI... the New York-N. New Jersey-Long Island, NY-NJ-CT fine particle (PM 2.5 ) nonattainment area has... determine that the New York-N. New Jersey-Long Island, NY[dash]NJ[dash]CT PM 2.5 nonattainment area...

41 CFR 101-45.002 - Gold.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 41 Public Contracts and Property Management 2 2014-07-01 2012-07-01 true Gold. 101-45.002 Section... PERSONAL PROPERTY § 101-45.002 Gold. (a) Gold will be sold in accordance with this section and part 102-38 of the Federal Management Regulation. (b) Sales of gold shall be processed to— (1) Use the sealed bid...

41 CFR 101-45.002 - Gold.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 41 Public Contracts and Property Management 2 2012-07-01 2012-07-01 false Gold. 101-45.002 Section... PERSONAL PROPERTY § 101-45.002 Gold. (a) Gold will be sold in accordance with this section and part 102-38 of the Federal Management Regulation. (b) Sales of gold shall be processed to— (1) Use the sealed bid...

41 CFR 101-45.002 - Gold.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true Gold. 101-45.002 Section... PERSONAL PROPERTY § 101-45.002 Gold. (a) Gold will be sold in accordance with this section and part 102-38 of the Federal Management Regulation. (b) Sales of gold shall be processed to— (1) Use the sealed bid...

41 CFR 101-45.002 - Gold.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 2 2013-07-01 2012-07-01 true Gold. 101-45.002 Section... PERSONAL PROPERTY § 101-45.002 Gold. (a) Gold will be sold in accordance with this section and part 102-38 of the Federal Management Regulation. (b) Sales of gold shall be processed to— (1) Use the sealed bid...

41 CFR 101-45.002 - Gold.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Gold. 101-45.002 Section... PERSONAL PROPERTY § 101-45.002 Gold. (a) Gold will be sold in accordance with this section and part 102-38 of the Federal Management Regulation. (b) Sales of gold shall be processed to— (1) Use the sealed bid...

Phytomedicines prepared from Arnica flowers inhibit the transcription factors AP-1 and NF-kappaB and modulate the activity of MMP1 and MMP13 in human and bovine chondrocytes.

PubMed

Jäger, Christoph; Hrenn, Andrea; Zwingmann, Jörn; Suter, Andreas; Merfort, Irmgard

2009-10-01

Arnica preparations have long been used for the symptomatic treatment of rheumatic complaints and recent clinical trials have demonstrated the beneficial effects of Arnica preparations in the treatment of osteoarthritis (OA). The efficacy of Arnica is presumed to be mainly due to its anti-inflammatory properties and inhibition of the transcription factor NF-kappaB. Here we provide further insights into its molecular mode of action. Arnica preparations suppress MMP1 and MMP13 mRNA levels in bovine and human articular chondrocytes in a concentration-dependent manner and in a low concentration range. This suppression may be due to inhibition of DNA binding of the transcription factors AP-1 and NF-kappaB. Interestingly, sesquiterpene lactones present in the preparations were always more active than the pure compounds, demonstrating the advantage of using plant preparations. Georg Thieme Verlag KG Stuttgart, New York.

Botany Bay and Cape York with Vertical Exaggeration

NASA Image and Video Library

2011-12-07

This graphic combines a perspective view from NASA Mars Reconnaissance Orbiter of the Botany Bay and Cape York areas of the rim of Endeavour Crater on Mars, and an inset with mapping-spectrometer data.

Ground-water resources of the Clifton Park area, Saratoga County, New York

USGS Publications Warehouse

Heisig, Paul M.

2002-01-01

Ground water is the sole source of public water supply for Clifton Park, a growing suburban community north of Albany, New York. Increasing water demand, coupled with concerns over ground-water quantity and quality, led the Clifton Park Water Authority in 1995 to initiate a cooperative study with the U.S. Geological Survey to update and refine the understanding of ground-water resources in the area.Ground-water resources are largely associated with three aquifers in the eastern half of the area. These aquifers overlie or encompass the Colonie Channel, a north-south-oriented bedrock channel that is filled primarily with lacustrine glacial deposits. The three aquifers are: (1) an unconfined lacustrine sand aquifer, (2) the Colonie Channel aquifer, which is confined within the deepest parts of the channel and variably confined and unconfined within the shallower, peripheral channel areas, and (3) an unconfined alluvial aquifer beneath the Mohawk River flood plain, which represents the southern limit of the study area. The lacustrine sand aquifer has little potential for large-scale withdrawals because it is predominantly fine grained and is susceptible to contamination from human activities at land surface. Water from this aquifer can, however, recharge the underlying peripheral parts of the Colonie Channel aquifer where hydraulic connections are present. The Colonie Channel aquifer consists of thin sand and gravel and (or) shallow, fractured bedrock over much of the channel area; discontinuous deposits of thicker (more than 20 feet) sand and gravel are common in the peripheral channel areas. The deepest, or central, channel area of this aquifer is isolated from the overlying lacustrine sand aquifer by a continuous lacustrine silt and clay unit, which is the primary channel-fill deposit. The most productive areas of the Colonie Channel aquifer are typically the shallow peripheral areas, where conditions range from unconfined to confined. The most productive aquifer

46 CFR 163.002-3 - Applicable technical regulations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 6 2010-10-01 2010-10-01 false Applicable technical regulations. 163.002-3 Section 163.002-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL CONSTRUCTION Pilot Hoist § 163.002-3 Applicable technical regulations...

R1: Platelets and Megakaryocytes contain functional NF-κB

PubMed Central

Spinelli, Sherry L.; Casey, Ann E.; Pollock, Stephen J.; Gertz, Jacqueline M.; McMillan, David H.; Narasipura, Srinivasa D.; Mody, Nipa A.; King, Michael R.; Maggirwar, Sanjay B.; Francis, Charles W.; Taubman, Mark B.; Blumberg, Neil; Phipps, Richard P.

2010-01-01

The Nuclear Factor (NF)-κB transcription factor family is well-known for their role in eliciting inflammation and promoting cell survival. We discovered that human megakaryocytes and platelets express the majority of NF-κB family members including the regulatory Inhibitor (I)-κB and Inhibitor Kappa Kinase (IKK) molecules. Objective Investigate the presence and role of NF-κB proteins in megakaryocytes and platelets. Methods and Results Anucleate platelets exposed to NF-κB inhibitors demonstrated impaired fundamental functions involved in repairing vascular injury and thrombus formation. Specifically, NF-κB inhibition diminished lamellapodia formation, decreased clot retraction times and reduced thrombus stability. Moreover, inhibition of I-κB-α phosphorylation (BAY-11-7082) reverts fully spread platelets back to a spheroid morphology. Addition of recombinant IKK-β or I-κB-α protein to BAY inhibitor-treated platelets partially restore platelet spreading in I-κB-α inhibited platelets, and addition of active IKK-β increased endogenous I-κB-α phosphorylation levels. Conclusions These novel findings support a crucial and non-classical role for the NF-κB family in modulating platelet function and reveal that platelets are sensitive to NF-κB inhibitors. As NF-κB inhibitors are being developed as anti-inflammatory and anti-cancer agents, they may have unintended effects on platelets. Based on these data, NF-κB is also identified as a new target to dampen unwanted platelet activation. PMID:20042710

42 CFR 483.114 - Annual review of NF residents.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Annual review of NF residents. 483.114 Section 483... Screening and Annual Review of Mentally Ill and Mentally Retarded Individuals § 483.114 Annual review of NF... physical and mental condition, the resident requires— (1) The level of services provided by— (i) A NF; (ii...

NF-kappaB modulators from Valeriana officinalis.

PubMed

Jacobo-Herrera, Nadia J; Vartiainen, Nina; Bremner, Paul; Gibbons, Simon; Koistinaho, Jari; Heinrich, Michael

2006-10-01

Valeriana officinalis (Valerianaceae) has been of great interest for its therapeutic uses for treating mild nervous tension and temporary sleeping problems. In traditional European medicine it has been also reported as an antiinflammatory remedy. This study reports that the EtOAc extract of the underground parts of V. officinalis showed inhibitory activity against NF-kappaB at 100 microg/mL in the IL-6/Luc assay on HeLa cells and provided protection against excitotoxicity in primary brain cell cultures at micromolar concentrations. Bioassay-guided fractionation of the EtOAc extract led to the isolation of three known sesquiterpenes: acetylvalerenolic acid (1), valerenal (2) and valerenic acid (3), 1 and 3 were active as inhibitors of NF-kappaB at a concentration of 100 microg/mL. Acetylvalerenolic acid (1) reduced NF-kappaB activity to 4%, whereas valerenic acid (3) reduced NF-kappaB activity to 25%. Copyright 2006 John Wiley & Sons, Ltd.

NF-{kappa}B regulates Lef1 gene expression in chondrocytes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yun, Kangsun; Choi, Yoo Duk; Nam, Jong Hee

The relation of Wnt/{beta}-catenin signaling to osteoarthritis progression has been revealed with little information on the underlying molecular mechanism. In this study we found overexpression of Lef1 in cartilage tissue of osteoarthritic patients and elucidated molecular mechanism of NF-{kappa}B-mediated Lef1 gene regulation in chondrocytes. Treatment of IL-1{beta} augmented Lef1 upregulation and nuclear translocation of NF-{kappa}B in chondrocytes. Under IL-1{beta} signaling, treatment of NF-{kappa}B nuclear translocation inhibitor SN-50 reduced Lef1 expression. A conserved NF-{kappa}B-binding site between mouse and human was selected through bioinformatic analysis and mapped at the 14 kb upstream of Lef1 transcription initiation site. NF-{kappa}B binding to the sitemore » was confirmed by chromatin immunoprecipitation assay. Lef1 expression was synergistically upregulated by interactions of NF-{kappa}B with Lef1/{beta}-catenin in chondrocytes. Our results suggest a pivotal role of NF-{kappa}B in Lef1 expression in arthritic chondrocytes or cartilage degeneration.« less

Laboratory Surge Response to Pandemic (H1N1) 2009 Outbreak, New York City Metropolitan Area, USA

PubMed Central

Crawford, James M.; Stallone, Robert; Zhang, Fan; Gerolimatos, Mary; Korologos, Diamanto D.; Sweetapple, Carolyn; de Geronimo, Marcella; Dlugacz, Yosef; Armellino, Donna M.

2010-01-01

The North Shore–Long Island Jewish Health System Laboratories serve 15 hospitals and affiliated regional physician practices in the New York City metropolitan area, with virus testing performed at a central reference laboratory. The influenza A pandemic (H1N1) 2009 outbreak began in this area on April 24, 2009, and within weeks respiratory virus testing increased 7.5 times. In response, laboratory and client service workforces were increased, physical plant build-out was completed, testing paradigms were converted from routine screening tests and viral culture to a high-capacity molecular assay for respiratory viruses, laboratory information system interfaces were built, and same-day epidemiologic reports were produced. Daily review by leadership of data from emergency rooms, hospital facilities, and the Health System Laboratories enabled real-time management of unfolding events. The ability of System laboratories to rapidly increase to high-volume comprehensive diagnostics, including influenza A subtyping, provided key epidemiologic information for local and state public health departments. PMID:20031036

Laboratory surge response to pandemic (H1N1) 2009 outbreak, New York City metropolitan area, USA.

PubMed

Crawford, James M; Stallone, Robert; Zhang, Fan; Gerolimatos, Mary; Korologos, Diamanto D; Sweetapple, Carolyn; de Geronimo, Marcella; Dlugacz, Yosef; Armellino, Donna M; Ginocchio, Christine C

2010-01-01

The North Shore-Long Island Jewish Health System Laboratories serve 15 hospitals and affiliated regional physician practices in the New York City metropolitan area, with virus testing performed at a central reference laboratory. The influenza A pandemic (H1N1) 2009 outbreak began in this area on April 24, 2009, and within weeks respiratory virus testing increased 7.5 times. In response, laboratory and client service workforces were increased, physical plant build-out was completed, testing paradigms were converted from routine screening tests and viral culture to a high-capacity molecular assay for respiratory viruses, laboratory information system interfaces were built, and same-day epidemiologic reports were produced. Daily review by leadership of data from emergency rooms, hospital facilities, and the Health System Laboratories enabled real-time management of unfolding events. The ability of System laboratories to rapidly increase to high-volume comprehensive diagnostics, including influenza A subtyping, provided key epidemiologic information for local and state public health departments.

High Resolution Quaternary Seismic Stratigraphy of the New York Bight Continental Shelf

USGS Publications Warehouse

Schwab, William C.; Denny, J.F.; Foster, D.S.; Lotto, L.L.; Allison, M.A.; Uchupi, E.; Swift, B.A.; Danforth, W.W.; Thieler, E.R.; Butman, Bradford

2003-01-01

A principal focus for the U.S. Geological Survey (USGS) Coastal and Marine Geology Program (marine.usgs.gov) is regional reconnaissance mapping of inner-continental shelf areas, with initial emphasis on heavily used areas of the sea floor near major population centers. The objectives are to develop a detailed regional synthesis of the sea-floor geology in order to provide information for a wide range of management decisions and to form a basis for further investigations of marine geological processes. In 1995, the USGS, in cooperation with the U.S. Army Corps of Engineers (USACOE), New York District, began to generate reconnaissance maps of the continental shelf seaward of the New York - New Jersey metropolitan area. This mapping encompassed the New York Bight inner-continental shelf, one of the most heavily trafficked and exploited coastal regions in the United States. Contiguous areas of the Hudson Shelf Valley, the largest physiographic feature on this segment of the continental shelf, also were mapped as part of a USGS study of contaminated sediments (Buchholtz ten Brink and others, 1994; 1996). The goal of the reconnaissance mapping was to provide a regional synthesis of the sea-floor geology in the New York Bight area, including: (a) a description of sea-floor morphology; (b) a map of sea-floor sedimentary lithotypes; (c) the geometry and structure of the Cretaceous strata and Quaternary deposits; and (d) the geologic history of the region. Pursuing the course of this mapping effort, we obtained sidescan-sonar images of 100 % of the sea floor in the study area. Initial interpretations of these sidescan data were presented by Schwab and others, (1997a, 1997b, 2000a). High-resolution seismic-reflection profiles collected along each sidescan-sonar line used multiple acoustic sources (e.g., watergun, CHIRP, Geopulse). Multibeam swath-bathymetry data also were obtained for a portion of the study area (Butman and others, 1998;). In this report, we present a series

Mechanisms of NF-κB deregulation in lymphoid malignancies.

PubMed

Krappmann, Daniel; Vincendeau, Michelle

2016-08-01

Deregulations promoting constitutive activation of canonical and non-canonical NF-κB signaling are a common feature of many lymphoid malignancies. Due to their cellular origin and the pivotal role of NF-κB for the normal function of B lymphocytes, B-cell malignancies are particularly prone to genetic aberrations that affect the pathway. Key positive regulators of NF-κB signaling can act as oncogenes that are often prone to chromosomal translocation, amplifications or activating mutations. Negative regulators of NF-κB have tumor suppressor functions and are frequently inactivated either by genomic deletions or point mutations. Whereas some aberrations are found in a variety of different lymphoid malignancies, some oncogenic alterations are very restricted to distinct lymphoma subsets, reflecting the clonal and cellular origin of specific lymphoma entities. NF-κB activation in many lymphoma cells is also driven by the microenvironment or chronic signaling that does not rely on genetic alterations. A number of drugs that target the NF-κB pathway are in preclinical or clinical development, revealing that there will be new options for therapies in the future. Since each lymphoma entity utilizes distinct mechanisms to activate NF-κB, a major challenge is to elucidate the exact pathological processes in order to faithfully predict clinical responses to the different therapeutic approaches. Copyright © 2016 Elsevier Ltd. All rights reserved.

Evaluation of Selected New York City Umbrella Programs, 1974-1975 School Year.

ERIC Educational Resources Information Center

Fordham Univ., Bronx, NY. Inst. for Research and Evaluation.

An evaluation of twelve different New York City Umbrella Programs coordinated in New York City public schools during the 1974-1975 school year is contained in this document. This report presents a description and evaluation of these programs, together with the major findings. The programs were implemented in the following areas: (1) tutoring in…

New York State's School Library Evaluation

ERIC Educational Resources Information Center

Jaeger, Paige

2012-01-01

The New York State's School Library Media Program Evaluation (SLMPE) rubric provides a window of opportunity for a librarian to talk with his/her administrators about library program elements that may be out of the librarian's control. There are three areas of focus on the SLMPE Rubric: (1) Teaching and Learning; (2) Building and Learning…

iss002e6675

NASA Image and Video Library

2001-05-15

ISS002-E-6675 (15 May 2001) --- James S. Voss, Expedition Two flight engineer, wearing a safety harness, exercises on the Treadmill Vibration Isolation System (TVIS) equipment in the Zvezda Service Module. This image was taken with a digital still camera.

33 CFR 167.155 - Off New York: Southern approach.

Code of Federal Regulations, 2014 CFR

2014-07-01

... (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.155 Off New York: Southern approach. (a) A...

33 CFR 167.153 - Off New York: Eastern approach.

Code of Federal Regulations, 2012 CFR

2012-07-01

... (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.153 Off New York: Eastern approach. (a) A...

33 CFR 167.153 - Off New York: Eastern approach.

Code of Federal Regulations, 2013 CFR

2013-07-01

... (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.153 Off New York: Eastern approach. (a) A...

33 CFR 167.155 - Off New York: Southern approach.

Code of Federal Regulations, 2013 CFR

2013-07-01

... (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.155 Off New York: Southern approach. (a) A...

33 CFR 167.153 - Off New York: Eastern approach.

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.153 Off New York: Eastern approach. (a) A...

33 CFR 167.155 - Off New York: Southern approach.

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.155 Off New York: Southern approach. (a) A...

33 CFR 167.155 - Off New York: Southern approach.

Code of Federal Regulations, 2011 CFR

2011-07-01

... (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.155 Off New York: Southern approach. (a) A...

33 CFR 167.155 - Off New York: Southern approach.

Code of Federal Regulations, 2012 CFR

2012-07-01

... (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.155 Off New York: Southern approach. (a) A...

33 CFR 167.153 - Off New York: Eastern approach.

Code of Federal Regulations, 2011 CFR

2011-07-01

... (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.153 Off New York: Eastern approach. (a) A...

33 CFR 167.153 - Off New York: Eastern approach.

Code of Federal Regulations, 2014 CFR

2014-07-01

... (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.153 Off New York: Eastern approach. (a) A...

NF-E2 Overexpression Delays Erythroid Maturation and Increases Erythrocyte Production

PubMed Central

Mutschler, Manuel; Magin, Angela S.; Buerge, Martina; Roelz, Roland; Schanne, Daniel H.; Will, Britta; Pilz, Ingo H.; Migliaccio, Anna Rita; Pahl, Heike L.

2009-01-01

Summary The transcription factor Nuclear Factor-Erythroid 2 (NF-E2) is overexpressed in the vast majority of patients with polycythaemia vera (PV). In murine models, NF-E2 overexpression increases proliferation and promotes cellular viability in the absence of erythropoietin (EPO). EPO-independent growth is a hallmark of PV. We therefore hypothesized that NF-E2 overexpression contributes to erythrocytosis, the pathognomonic feature of PV. Consequently, we investigated the effect of NF-E2 overexpression in healthy CD34+ cells. NF-E2 overexpression led to a delay in erythroid maturation, manifested by a belated appearance of glycophorin A-positive erythroid precursors. Maturation delay was similarly observed in primary PV patient erythroid cultures compared to healthy controls. Protracted maturation led to a significant increase in the accumulated number of erythroid cells both in PV cultures and in CD34+ cells overexpressing NF-E2. Similarly, NF-E2 overexpression altered erythroid colony formation, leading to an increase in BFU-E formation. These data indicate that NF-E2 overexpression delays the early phase of erythroid maturation, resulting in an expansion of erythroid progenitors, thereby increasing the number of erythrocytes derived from one CD34+ cell. These data propose a role for NF-E2 in mediating the erythrocytosis of PV. PMID:19466964

Modeled distributions of 12 tree species in New York

Treesearch

Rachel I. Riemann; Barry T. Wilson; Andrew J. Lister; Oren Cook; Sierra Crane-Murdoch

2014-01-01

These maps depict the distribution of 12 tree species across the state of New York. The maps show where these trees do not occur (gray), occasionally occur (pale green), are a minor component (medium green), are a major component (dark green), or are the dominant species (black) in the forest, as determined by that species' total basal area. Basal area is the area...

Impact of the NOx SIP Call on Respiratory Hospitalizations in New York State

EPA Science Inventory

Asthma is a serious public health problem in New York State (NYS), affecting 8.4% (370,000) children and 7.6% (more than 1.1 million) adults. Asthma burden in New York's urban areas is consistently higher than the national average, with marked differences in prevalence and seve...

Direct non transcriptional role of NF-Y in DNA replication.

PubMed

Benatti, Paolo; Belluti, Silvia; Miotto, Benoit; Neusiedler, Julia; Dolfini, Diletta; Drac, Marjorie; Basile, Valentina; Schwob, Etienne; Mantovani, Roberto; Blow, J Julian; Imbriano, Carol

2016-04-01

NF-Y is a heterotrimeric transcription factor, which plays a pioneer role in the transcriptional control of promoters containing the CCAAT-box, among which genes involved in cell cycle regulation, apoptosis and DNA damage response. The knock-down of the sequence-specific subunit NF-YA triggers defects in S-phase progression, which lead to apoptotic cell death. Here, we report that NF-Y has a critical function in DNA replication progression, independent from its transcriptional activity. NF-YA colocalizes with early DNA replication factories, its depletion affects the loading of replisome proteins to DNA, among which Cdc45, and delays the passage from early to middle-late S phase. Molecular combing experiments are consistent with a role for NF-Y in the control of fork progression. Finally, we unambiguously demonstrate a direct non-transcriptional role of NF-Y in the overall efficiency of DNA replication, specifically in the DNA elongation process, using a Xenopus cell-free system. Our findings broaden the activity of NF-Y on a DNA metabolism other than transcription, supporting the existence of specific TFs required for proper and efficient DNA replication. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

PBC triggers in water reservoirs, coal mining areas and waste disposal sites: from Newcastle to New York.

PubMed

Smyk, Daniel; Mytilinaiou, Maria G; Rigopoulou, Eirini I; Bogdanos, Dimitrios P

2010-01-01

Various environmental factors have been proposed as triggers of primary biliary cirrhosis (PBC), a progressive autoimmune cholestatic liver disease which is characterised by the destruction of the small intrahepatic bile ducts. Support for their pathogenic role in PBC is provided by epidemiological studies reporting familial clustering and clusters of the disease within a given geographical area. The seminal study by Triger reporting that the great majority of PBC cases in the English city of Sheffield drank water from a specific water reservoir, has been followed by studies reporting disease 'hot spots' within a restricted geographic region of the former coal mining area of Newcastle. The New York study reporting an increased risk and significant clustering of PBC cases near toxic federal waste disposal sites has added strength to the notion that environmental factors, possibly in the form of infectious agents or toxic/chemical environmental factors in areas of contaminated land, water or polluted air may play a key role in the development of the disease. This review discusses the findings of reports investigating environmental factors which may contribute to the cause of primary biliary cirrhosis.

Knockdown of NF-κB1 by shRNA Inhibits the Growth of Renal Cell Carcinoma In Vitro and In Vivo.

PubMed

Ikegami, Amanda; Teixeira, Luiz Felipe S; Braga, Marina S; Dias, Matheus Henrique Dos S; Lopes, Eduardo C; Bellini, Maria Helena

2018-06-11

Renal cell carcinoma (RCC) accounts for approximately 2%-3% of human malignancies and is the most aggressive among urologic tumors. Biological heterogeneity, drug resistance, and chemotherapy side effects are the biggest obstacles to the effective treatment of RCC. The NF-κB transcription factor is one of several molecules identified to be responsible for the aggressive phenotype of this tumor. In the past decade, several studies have demonstrated the activation of NF-κB in RCC, and many have implicated NF-κB1 (p50) as an important molecule in tumor progression and metastasis. In the present study, a lentivirus was used to deliver shRNA targeting NF-κB1 into mouse RCC (Renca) cells. It was determined that the knockdown of the NF-κB1 gene led to a reduction in cell proliferation and late apoptosis/necrosis in vitro. Flow cytometry analysis demonstrated G2/M arrest in the cells. In addition, immunoblotting analysis revealed a significant increase in cyclin B1 and Bax. In vivo experiments showed that Renca-shRNA-NF-κB1 cells have significantly diminished tumorigenicity. Moreover, immunohistochemical analysis revealed an increase in necrotic areas of Renca-shRNA-NF-κB1 tumors. Thus, this study indicates that downregulation of NF-κB1 can suppress RCC tumorigenesis by inducing late apoptosis/necrosis. Therefore, NF-κB1 may be a potential therapeutic target for RCC.

Simultaneous imaging of temporal changes of NF-κB activity and viable tumor cells in Huh7/NF-κB-tk-luc2/rfp tumor-bearing mice.

PubMed

Wang, Wei-Hsun; Chiang, I-Tsang; Liu, Yu-Chang; Hsu, Fei-Ting; Chen, Hong-Wen; Chen, Chuan-Lin; Lee, Yi-Jang; Lin, Wuu-Jyh; Hwang, Jeng-Jong

2013-01-01

Few studies have reported that the effect of sorafenib on advanced human hepatocellular carcinoma (HCC) is taking place via the inhibition of NF-κB signal transduction. Here we constructed a human HCC Huh7 stable clone with NF-κB-responsive element to drive dual reporter genes, herpes simplex virus thymidine kinase (tk) and firefly luciferase (luc2), and co-transfected with a third red fluorescent protein (rfp) gene, renamed as Huh7/NF-κB-tk-luc2/rfp cells, and combined with bioluminescent imaging (BLI) and red fluorescent protein imaging (RFPI) to monitor the effect of sorafenib on NF-κB activation and tumor inhibition. The results show that sorafenib could suppress the NF-κB-DNA binding activity, and the expression of downstream effector proteins. Notably, the relative photon fluxes obtained from RFPI and BLI, which represent the viable tumor cells and cells with NF-κB activation, decreased after sorafenib treatment by 50 to 65%, and 87.5 to >90%, respectively, suggesting that NF-κB activation is suppressed in viable HCC cells by sorafenib. Simultaneous molecular imaging of the temporal change of NF-κB activity and of viable cells in the same Huh7/NF-κB-tk-luc2/rfp tumors of the animal may reflect the real status of NF-κB activity and the viable tumor cells at the time of imaging.

Zebrafish as a Model to Study NF1-Associated Learning Deficits

DTIC Science & Technology

2016-07-01

characterized by attention deficit and learning disabilities . The NF1 protein govern distinct aspects of cognitive behavior: the NF1- GRD attenuates Ras...most prominently scholastic under-performance characterized by attention deficit and learning disabilities . The NF1 protein govern distinct...disorder associated with attention deficits and learning disabilities . The primary known function of neurofibromin, encoded by the NF1 gene, is to

NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao Guohua; Shi Lingfang; Qiu Daoming

2005-05-01

NF45/ILF2 associates with NF90/ILF3 in the nucleus and regulates IL-2 gene transcription at the antigen receptor response element (ARRE)/NF-AT DNA target sequence (P.N. Kao, L. Chen, G. Brock, J. Ng, A.J. Smith, B. Corthesy, J. Biol. Chem. 269 (1994) 20691-20699). NF45 is widely expressed in normal tissues, especially testis, brain, and kidney, with a predominantly nuclear distribution. NF45 mRNA expression is increased in lymphoma and leukemia cell lines. The human and murine NF45 proteins differ only by substitution of valine by isoleucine at amino acid 142. Fluorescence in situ hybridization localized the human NF45 gene to chromosome 1q21.3, and mousemore » NF45 gene to chromosome 3F1. Promoter analysis of 2.5 kB of the murine NF45 gene reveals that significant activation is conferred by factors, possible including NF-Y, that bind to the CCAAT-box sequence. The function of human NF45 in regulating IL-2 gene expression was characterized in Jurkat T-cells stably transfected with plasmids directing expression of NF45 cDNA in sense or antisense orientations. NF45 sense expression increased IL-2 luciferase reporter gene activity 120-fold, and IL-2 protein expression 2-fold compared to control cells. NF45 is a highly conserved, regulated transcriptional activator, and one target gene is IL-2.« less

Water Resources and Related Land Management, Buffalo Metropolitan Area, New York

DTIC Science & Technology

1991-04-01

4,797,800 and $2,566,500, respectively. In January 1986, the Buffalo District completed a letter report addressing ice- jam related flood problems at the...opposition to construction of an ice-retentlon structure at Versailles, New York, to reduce damages due to ice- jam flooding at the mouth of the creek. The...consists of two low earth dams In tandem, e:ach with its ,own outle!t works and energJency spillway, and four training dikes. 17 Snags and debris jams

Exchange Sex Among Persons Who Inject Drugs in the New York Metropolitan Area: The Importance of Local Context, Gender and Sexual Identity.

PubMed

Walters, Suzan M; Rivera, Alexis V; Reilly, Kathleen H; Anderson, Bridget J; Bolden, Barbara; Wogayehu, Afework; Neaigus, Alan; Braunstein, Sarah

2018-02-21

Exchanging sex for money or drugs is known to increase risk for HIV among persons who inject drugs (PWID). To better understand determinants of exchange sex among PWID we examined factors associated with exchange sex in the New York metropolitan area-defined as New York City (NYC), NY; Newark, NJ; and Long Island, NY-using data from the 2012 National HIV Behavioral Surveillance system cycle on injection drug use. Of the 1160 PWID in this analysis, 24% reported exchange sex, with differences in gender and sexual identity by location. In multivariable analysis gay/bisexual men, heterosexual women, and lesbian, gay, or bisexual (LGB) women were more likely to exchange sex compared to heterosexual men. Exchange sex was also associated with race/ethnicity, homelessness, incarceration, location, and non-injection crack and cocaine use. We find that heterosexual women and LGB women who injected drugs residing in Newark were more likely to report exchange sex compared to NYC. This study highlights how local conditions impact exchange sex.

ARC-2010-ACD10-0047-002

NASA Image and Video Library

2010-03-09

ARC Sculpture by Peter Gutkin 'Nice Ice in New York' circa 1970's. This sculputre was donated to Ames Research Center by the artist. Peter Gutkin has designed special interiors, exhibits, and display furniture for Ames since 1979. He currently maintains an office in San Francisco, CA.

Investigating the Effect of Social Changes on Age-Specific Gun-Related Homicide Rates in New York City During the 1990s

PubMed Central

Messner, Steven F.; Tracy, Melissa; Vlahov, David; Goldmann, Emily; Tardiff, Kenneth J.; Galea, Sandro

2010-01-01

Objectives. We assessed whether New York City's gun-related homicide rates in the 1990s were associated with a range of social determinants of homicide rates. Methods. We used cross-sectional time-series data for 74 New York City police precincts from 1990 through 1999, and we estimated Bayesian hierarchical models with a spatial error term. Homicide rates were estimated separately for victims aged 15–24 years (youths), 25–34 years (young adults), and 35 years or older (adults). Results. Decreased cocaine consumption was associated with declining homicide rates in youths (posterior median [PM] = 0.25; 95% Bayesian confidence interval [BCI] = 0.07, 0.45) and adults (PM = 0.07; 95% BCI = 0.02, 0.12), and declining alcohol consumption was associated with fewer homicides in young adults (PM = 0.14; 95% BCI = 0.02, 0.25). Receipt of public assistance was associated with fewer homicides for young adults (PM = –104.20; 95% BCI = –182.0, –26.14) and adults (PM = –28.76; 95% BCI = –52.65, –5.01). Misdemeanor policing was associated with fewer homicides in adults (PM = –0.01; 95% BCI = –0.02, –0.001). Conclusions. Substance use prevention policies and expansion of the social safety net may be able to cause major reductions in homicide among age groups that drive city homicide trends. PMID:20395590

Smoothing single-crystalline SiC surfaces by reactive ion etching using pure NF{sub 3} and NF{sub 3}/Ar mixture gas plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tasaka, Akimasa, E-mail: aki-tasaka-load@yahoo.co.jp; Kotaka, Yuki; Oda, Atsushi

2014-09-01

In pure NF{sub 3} plasma, the etching rates of four kinds of single-crystalline SiC wafer etched at NF{sub 3} pressure of 2 Pa were the highest and it decreased with an increase in NF{sub 3} pressure. On the other hand, they increased with an increase in radio frequency (RF) power and were the highest at RF power of 200 W. A smooth surface was obtained on the single-crystalline 4H-SiC after reactive ion etching at NF{sub 3}/Ar gas pressure of 2 Pa and addition of Ar to NF{sub 3} plasma increased the smoothness of SiC surface. Scanning electron microscopy observation revealed that the numbermore » of pillars decreased with an increase in the Ar-concentration in the NF{sub 3}/Ar mixture gas. The roughness factor (R{sub a}) values were decreased from 51.5 nm to 25.5 nm for the As-cut SiC, from 0.25 nm to 0.20 nm for the Epi-SiC, from 5.0 nm to 0.7 nm for the Si-face mirror-polished SiC, and from 0.20 nm to 0.16 nm for the C-face mirror-polished SiC by adding 60% Ar to the NF{sub 3} gas. Both the R{sub a} values of the Epi- and the C-face mirror-polished wafer surfaces etched using the NF{sub 3}/Ar (40:60) plasma were similar to that treated with mirror polishing, so-called the Catalyst-Referred Etching (CARE) method, with which the lowest roughness of surface was obtained among the chemical mirror polishing methods. Etching duration for smoothing the single-crystalline SiC surface using its treatment was one third of that with the CARE method.« less

Ras-Independent Function of NF1

DTIC Science & Technology

2013-05-01

required to fulfill this process. Moreover, the skin disease we observed in those mice is psoriasis . 15. SUBJECT TERMS Neurofibromin (NF1), Ras...factor such as age contributes to the process. 3d. Proposed work: Determine the relation between NF1 and psoriasis (months 13-24). We will collect...several psoriasis related genes, such as Th17, IL22, IL23, CD68, CXCL8, CCL2, defensin-2 by quantitative PCR in the skin samples from the lesions

33 CFR 110.60 - Captain of the Port, New York.

Code of Federal Regulations, 2014 CFR

2014-07-01

... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.60 Captain of the Port, New York. (a) Western... Harbors before any mooring is placed in this special anchorage area. (3) Glen Island, East. All waters... includes this special anchorage area. (14) Little Neck Bay. All waters east of a line drawn from 40°47′39.4...

33 CFR 110.60 - Captain of the Port, New York.

Code of Federal Regulations, 2012 CFR

2012-07-01

... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.60 Captain of the Port, New York. (a) Western... Harbors before any mooring is placed in this special anchorage area. (3) Glen Island, East. All waters... includes this special anchorage area. (14) Little Neck Bay. All waters east of a line drawn from 40°47′39.4...

33 CFR 110.60 - Captain of the Port, New York.

Code of Federal Regulations, 2013 CFR

2013-07-01

... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.60 Captain of the Port, New York. (a) Western... Harbors before any mooring is placed in this special anchorage area. (3) Glen Island, East. All waters... includes this special anchorage area. (14) Little Neck Bay. All waters east of a line drawn from 40°47′39.4...

An assessment of radon in groundwater in New York State

USGS Publications Warehouse

Shaw, Stephen B.; Eckhardt, David A.V.

2012-01-01

Abstract: A set of 317 samples collected from wells throughout New York State (excluding Long Island) from 2003 through 2008 was used to assess the distribution of radon gas in drinking water. Previous studies have documented high concentrations of radon in groundwater from granitic and metamorphic bedrock, but there have been only limited characterizations of radon in water from sedimentary rock and unconsolidated sand-and-gravel deposits in New York. Approximately 8% of the samples from bedrock wells exceed 89 Bq L-1 (eight times the proposed regulatory limit), but only 2% of samples from sand-and-gravel wells exceed 44 Bq L-1. Specific metamorphic and sedimentary rock formations in New York are associated with the high radon concentrations, indicating that specific areas of New York could be targeted with efforts to reduce the risk of exposure to radon in groundwater. Additionally, radon in groundwater from the sand-and-gravel aquifers was found to be directly correlated to radon in indoor air when assessed by county.

Heats of NF(sub n) (n= 1-3) and NF(sub n)(+)(n = 1-3)

NASA Technical Reports Server (NTRS)

Ricca, Alessandra; Arnold, James (Technical Monitor)

1998-01-01

Accurate heats of formation are computed for NF(sub n) and NF(sub n)(+), for n = 1-3. The geometries and the vibrational frequencies are determined at the B3LYP level of theory. The energetics are determined at the CCSD(T) level of theory. Basis set limit values are obtained by extrapolation. In those cases where the CCSD(T) calculations become prohibitively large, the basis set extrapolation is performed at the MP2 level. The temperature dependence of the heat of formation, heat capacity, and entropy are computed for the temperature range 300 to 4000 K and fit to a polynomial.

Telomere erosion in NF1 tumorigenesis.

PubMed

Jones, Rhiannon E; Grimstead, Julia W; Sedani, Ashni; Baird, Duncan; Upadhyaya, Meena

2017-06-20

Neurofibromatosis type 1 (NF1; MIM# 162200) is a familial cancer syndrome that affects 1 in 3,500 individuals worldwide and is inherited in an autosomal dominant fashion. Malignant Peripheral Nerve Sheath Tumors (MPNSTs) represent a significant cause of morbidity and mortality in NF1 and currently there is no treatment or definite prognostic biomarkers for these tumors. Telomere shortening has been documented in numerous tumor types. Short dysfunctional telomeres are capable of fusion and it is considered that the ensuing genomic instability may facilitate clonal evolution and the progression to malignancy. To evaluate the potential role of telomere dysfunction in NF1-associated tumors, we undertook a comparative analysis of telomere length in samples derived from 10 cutaneous and 10 diffused plexiform neurofibromas, and 19 MPNSTs. Telomere length was determined using high-resolution Single Telomere Length Analysis (STELA). The mean Xp/Yp telomere length detected in MPNSTs, at 3.282 kb, was significantly shorter than that observed in both plexiform neurofibromas (5.793 kb; [p = 0.0006]) and cutaneous neurofibromas (6.141 kb; [p = 0.0007]). The telomere length distributions of MPNSTs were within the length-ranges in which telomere fusion is detected and that confer a poor prognosis in other tumor types. These data indicate that telomere length may play a role in driving genomic instability and clonal progression in NF1-associated MPNSTs.

Economic and Technical Feasibility Study of Utility-Scale Wind Generation for the New York Buffalo River and South Buffalo Brownfield Opportunity Areas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberts, J. O.; Mosey, G.

2014-04-01

Through the RE-Powering America's Land initiative, the economic and technical feasibility of utilizing contaminated lands in the Buffalo, New York, area for utility-scale wind development is explored. The study found that there is available land, electrical infrastructure, wind resource, and local interest to support a commercial wind project; however, economies of scale and local electrical markets may need further investigation before significant investment is made into developing a wind project at the Buffalo Reuse Authority site.

48 CFR 410.002 - Procedures.

Code of Federal Regulations, 2014 CFR

2014-10-01

... ACQUISITION PLANNING MARKET RESEARCH 410.002 Procedures. Market research must include obtaining information on the commercial quality assurance practices as an alternative for Government inspection and testing...

48 CFR 410.002 - Procedures.

Code of Federal Regulations, 2013 CFR

2013-10-01

... ACQUISITION PLANNING MARKET RESEARCH 410.002 Procedures. Market research must include obtaining information on the commercial quality assurance practices as an alternative for Government inspection and testing...

48 CFR 410.002 - Procedures.

Code of Federal Regulations, 2012 CFR

2012-10-01

... ACQUISITION PLANNING MARKET RESEARCH 410.002 Procedures. Market research must include obtaining information on the commercial quality assurance practices as an alternative for Government inspection and testing...

Forest statistics for New York--1980

Treesearch

Thomas J., Jr. Considine; Thomas S. Frieswyk; Thomas S. Frieswyk

1982-01-01

A statistical report on the third forest survey of New York conducted in 1978 and 1979. Statistical findings are based on data from remeasured and new 10-point variable-radius plots. The current status of forest-land area, timber volume, and annual growth and removals is presented. Timber products output by timber industries, based on a 1979 updated canvass of...

48 CFR 734.002-70 - USAID policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Section 734.002-70 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT SPECIAL CATEGORIES OF CONTRACTING MAJOR SYSTEM ACQUISITION 734.002-70 USAID policy. In order for an USAID acquisition... part 34, and must have an estimated value of $15 million or more during the first year of the contract...

48 CFR 734.002-70 - USAID policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 734.002-70 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT SPECIAL CATEGORIES OF CONTRACTING MAJOR SYSTEM ACQUISITION 734.002-70 USAID policy. In order for an USAID acquisition... part 34, and must have an estimated value of $15 million or more during the first year of the contract...

Regionalized equations for bankfull-discharge and channel characteristics of streams in New York State—Hydrologic Region 7 in western New York

USGS Publications Warehouse

Mulvihill, Christiane I.; Ernst, Anne G.; Baldigo, Barry P.

2006-01-01

Computation of bankfull discharge and channel dimensions (width, depth, and cross-sectional area) at ungaged sites requires equations that relate bankfull discharge and channel dimensions to drainage-area at gaged sites. Bankfull-channel information commonly is needed for watershed assessments, stream channel classification, and the design of stream-restoration projects. Such equations are most accurate if they are derived on the basis of data from streams within a region of uniform hydrologic, climatic, and physiographic conditions and applied only within that region. New York State contains eight hydrologic regions that were previously delineated on the basis of high-flow (flood) characteristics. This report presents drainage areas and associated bankfull characteristics (discharge and channel dimensions) for surveyed streams in western New York (Region 7).Stream-survey data and discharge records from seven active and three inactive USGS streamflow-gaging stations were used in regression analyses to relate drainage area to bankfull discharge and to bankfull channel width, depth, and cross-sectional area. The resulting equations are:(1) bankfull discharge, in cubic feet per second = 37.1*(drainage area, in square miles)0.765;(2) bankfull channel width, in feet = 10.8*(drainage area, in square miles)0.458;(3) bankfull channel depth, in feet = 1.47*(drainage area, in square miles)0.199; and(4) bankfull channel cross-sectional area, in square feet = 15.9*(drainage area, in square mile)0.656.The coefficients of determination (R2) for these four equations were 0.94, 0.89, 0.52, and 0.96, respectively. The high coefficients of determination for three of these equations (discharge, width, and cross-sectional area) indicate that much of the range in the variables was explained by the drainage area. The low coefficient of determination for the equation relating bankfull depth to drainage area, however, suggests that other factors also affected water depth. Recurrence

Suppression of NF-κB and NF-κB-Regulated Gene Expression by Apigenin through IκBα and IKK Pathway in TRAMP Mice

PubMed Central

Shukla, Sanjeev; Shankar, Eswar; Fu, Pingfu; MacLennan, Gregory T.; Gupta, Sanjay

2015-01-01

Aberrant Nuclear Factor-κappaB (NF-κB) activation due to rapid IκBα turnover and high basal IκBα kinase (IKK) activity has been frequently observed in prostate cancer. Apigenin, a naturally occurring plant flavone, exhibits anti-proliferative, anti-inflammatory and anti-carcinogenic activities by inhibiting NF-κB pathway, through a mechanism not fully understood. We found that apigenin feeding in microgram doses (bioavailable in humans) inhibited prostate tumorigenesis in TRAMP mice by interfering with NF-κB signaling. Apigenin feeding to TRAMP mice (20 and 50 μg/mouse/day, 6 days/week for 20 weeks) exhibited significant decrease in tumor volumes of the prostate and completely abolished metastasis, which correlated with inhibition of NF-κB activation and binding to the DNA. Apigenin intake blocked phosphorylation and degradation of IκBα by inhibiting IKK activation, which in turn led to suppression of NF-κB activation. The expression of NF-κB-regulated gene products involved in proliferation (cyclin D1, and COX-2), anti-apoptosis (Bcl-2 and Bcl-xL), and angiogenesis (vascular endothelial growth factor) were also downregulated after apigenin feeding. These events correlated with the induction of apoptosis in tumor cells, as evident by increased cleaved caspase-3 labeling index in the dorsolateral prostate. Our results provide convincing evidence that apigenin inhibits IKK activation and restores the expression of IκBα, preventing it’s phosphorylation in a fashion similar to that elicited by IKK and proteasomal inhibitors through suppression of NF-κB signaling pathway. PMID:26379052

Genetic and epigenetic alteration of the NF2 gene in sporadic meningiomas.

PubMed

Lomas, Jesus; Bello, M Josefa; Arjona, Dolores; Alonso, M Eva; Martinez-Glez, Victor; Lopez-Marin, Isabel; Amiñoso, Cinthia; de Campos, Jose M; Isla, Alberto; Vaquero, Jesus; Rey, Juan A

2005-03-01

The role of the NF2 gene in the development of meningiomas has recently been documented; inactivating mutations plus allelic loss at 22q, the site of this gene (at 22q12), have been identified in both sporadic and neurofibromatosis type 2-associated tumors. Although epigenetic inactivation through aberrant CpG island methylation of the NF2 5' flanking region has been documented in schwannoma (another NF2-associated neoplasm), data on participation of this epigenetic modification in meningiomas are not yet widely available. Using methylation-specific PCR (MSP) plus sequencing, we assessed the presence of aberrant promoter NF2 methylation in a series of 88 meningiomas (61 grade I, 24 grade II, and 3 grade III), in which the allelic constitution at 22q and the NF2 mutational status also were determined by RFLP/microsatellite and PCR-SSCP analyses. Chromosome 22 allelic loss, NF2 gene mutation, and aberrant NF2 promoter methylation were detected in 49%, 24%, and 26% of cases, respectively. Aberrant NF2 methylation with loss of heterozygosity (LOH) at 22q was found in five cases, and aberrant methylation with NF2 mutation in another; LOH 22q and the mutation were found in 16 samples. The aberrant methylation of the NF2 gene also was the sole alteration in 15 samples, most of which were from grade I tumors. These results indicate that aberrant NF2 hypermethylation may participate in the development of a significant proportion of sporadic meningiomas, primarily those of grade I.

Instanton dominance over αs at low momenta from lattice QCD simulations at Nf = 0, Nf = 2 + 1 and Nf = 2 + 1 + 1

NASA Astrophysics Data System (ADS)

Athenodorou, Andreas; Boucaud, Philippe; de Soto, Feliciano; Rodríguez-Quintero, José; Zafeiropoulos, Savvas

2018-03-01

We report on an instanton-based analysis of the gluon Green functions in the Landau gauge for low momenta; in particular we use lattice results for αs in the symmetric momentum subtraction scheme (MOM) for large-volume lattice simulations. We have exploited quenched gauge field configurations, Nf = 0, with both Wilson and tree-level Symanzik improved actions, and unquenched ones with Nf = 2 + 1 and Nf = 2 + 1 + 1 dynamical flavors (domain wall and twisted-mass fermions, respectively). We show that the dominance of instanton correlations on the low-momenta gluon Green functions can be applied to the determination of phenomenological parameters of the instanton liquid and, eventually, to a determination of the lattice spacing. We furthermore apply the Gradient Flow to remove short-distance fluctuations. The Gradient Flow gets rid of the QCD scale, ΛQCD, and reveals that the instanton prediction extents to large momenta. For those gauge field configurations free of quantum fluctuations, the direct study of topological charge density shows the appearance of large-scale lumps that can be identified as instantons, giving access to a direct study of the instanton density and size distribution that is compatible with those extracted from the analysis of the Green functions.

Evaluation of NF-kappaB Pathway Inhibition for Space Radiation Biology Research

NASA Astrophysics Data System (ADS)

Koch, Kristina; Hellweg, Christine; Baumstark-Khan, Christa; Schmitz, Claudia; Lau, Patrick; Testard, Isabelle; Reitz, Guenther

Radiation is a potentially limiting factor for long term orbital and interplanetary missions. To improve risk estimation and to allow development of appropriate countermeasures, the study of the cellular radiation response is necessary. The anti-apoptotic factor nuclear factor κB (NF-κB) was identified as important modulating factor in the cellular response to heavy ions (Radiat. Res. 164: 527-530, 2005). This transcription factor could improve cellular survival after exposure to high radiation doses and influence the cancer risk of astronauts exposed to low doses of cosmic radiation. Therefore, the inhibition of selected NF-κB pathway compo-nents might help to identify possible pharmacological targets. It is supposed that the ATM kinase mediates the signal from damaged DNA in the nucleus to kinases in the cytoplasm. For liberation of NF-κB and its nuclear translocation, the inhibitor of NF-κB (IκB) has to be degraded in the proteasom. In this work, the efficacy and cytotoxicity of ATM, NF-κB and the proteasome inhibitors were analyzed using recombinant HEK-pNF-κB-d2EGFP/Neo cells. In the recommended concentration range, only the NF-κB inhibitor caffeic acid phenethyl ester (CAPE) displayed considerable cytotoxicity, while the others were not toxic. The inhibition of ATM by KU-55933 suppresses the X-ray and heavy ion (13 C, 35 MeV/u, LET 70 keV/m) induced activation of NF-κB dependent gene expression, indicating the central position of ATM in radiation induced NF-κB activation. CAPE and capsaicin partially inhibited NF-κB acti-vation by the cytokine tumor necrosis factor α. The proteasome inhibitor MG-132 completely abolished the activation and was therefore used for short-term incubation experiments with X-rays. MG-132 suppressed the X-ray induced NF-κB activation in HEK-pNF-κB-d2EGFP/Neo cells entirely. The results lead to the conclusion that ATM and the proteasomal degradation of IκB are essential prerequisites for radiation induced NF

Tomato Lycopene Extract Prevents Lipopolysaccharide-Induced NF-κB Signaling but Worsens Dextran Sulfate Sodium-Induced Colitis in NF-κBEGFP Mice

PubMed Central

Joo, Young-Eun; Karrasch, Thomas; Mühlbauer, Marcus; Allard, Brigitte; Narula, Acharan; Herfarth, Hans H.; Jobin, Christian

2009-01-01

Background The impact of tomato lycopene extract (TLE) on intestinal inflammation is currently unknown. We investigated the effect of TLE on lipopolysaccharide (LPS)-induced innate signaling and experimental colitis. Methodology/Principal Findings Mice were fed a diet containing 0.5 and 2% TLE or isoflavone free control (AIN-76). The therapeutic efficacy of TLE diet was assessed using dextran sulfate sodium (DSS) exposed mice and IL-10−/−;NF-κBEGFP mice, representing an acute and spontaneous chronic colitis model respectively. A mini-endoscope was used to determine the extent of macroscopic mucosal lesions. Murine splenocytes and intestinal epithelial cells were used to determine the in vitro impact of TLE on LPS-induced NF-κB signaling. In vitro, TLE blocked LPS-induced IκBα degradation, RelA translocation, NF-κB transcriptional activity and MIP-2 mRNA accumulation in IEC-18 cells. Moreover, LPS-induced IL-12p40 gene expression was dose-dependently inhibited in TLE-treated splenocytes. Interestingly, DSS-induced acute colitis worsened in TLE-fed NF-κBEGFP mice compared to control diet as measured by weight loss, colonoscopic analysis and histological scores. In contrast, TLE-fed IL-10−/−;NF-κBEGFP mice displayed decreased colonic EGFP expression compared to control diet. IL-6, TNFα, and MCP-1 mRNA expression were increased in the colon of TLE-fed, DSS-exposed NF-κBEGFP mice compared to the control diet. Additionally, caspase-3 activation and TUNEL positive cells were enhanced in TLE diet-fed, DSS-exposed mice as compared to DSS control mice. Conclusions/ Significance These results indicate that TLE prevents LPS-induced proinflammatory gene expression by blocking of NF-κB signaling, but aggravates DSS-induced colitis by enhancing epithelial cell apoptosis. PMID:19234608

Motor dysfunction in NF1: Mediated by attention deficit or inherent to the disorder?

PubMed

Haas-Lude, Karin; Heimgärtner, Magdalena; Winter, Sarah; Mautner, Victor-Felix; Krägeloh-Mann, Ingeborg; Lidzba, Karen

2018-01-01

Attention deficit and compromised motor skills are both prevalent in Neurofibromatosis type 1 (NF1), but the relationship is unclear. We investigated motor function in children with NF1 and in children with Attention Deficit/Hyperactivity Disorder (ADHD), and explored if, in patients with NF1, attention deficit influences motor performance. Motor performance was measured using the Movement Assessment Battery for Children (M-ABC) in 71 children (26 with NF1 plus ADHD, 14 with NF1 without ADHD, and 31 with ADHD without NF1) aged 6-12 years. There was a significant effect of group on motor performance. Both NF1 groups scored below children with ADHD without NF1. Attention performance mediated motor performance in children with ADHD without NF1, but not in children with NF1. Motor function is not mediated by attention performance in children with NF1. While in ADHD, attention deficit influences motor performance, motor problems in NF1 seem to be independent from attention deficit. This argues for different pathomechanisms in these two groups of developmental disorders. Copyright © 2017 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

Environmental Protection in the City of New York

ERIC Educational Resources Information Center

Eisenbud, Merril

1970-01-01

Reviews New York City's Environmental Protection Administration two-year effort in air, water, noise, and solid waste pollution control. Successes and difficulties are seen as applicable to other urban areas. Long-term planning considers population control, poverty programs, traffic management, and land use. (JM)

33 CFR 167.154 - Off New York: South-eastern approach.

Code of Federal Regulations, 2010 CFR

2010-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.154 Off New York: South-eastern approach...

33 CFR 167.154 - Off New York: South-eastern approach.

Code of Federal Regulations, 2012 CFR

2012-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.154 Off New York: South-eastern approach...

33 CFR 167.154 - Off New York: South-eastern approach.

Code of Federal Regulations, 2011 CFR

2011-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.154 Off New York: South-eastern approach...

RUSTING ORE TRAIN, ONCE PART OF NEW YORK ELEVATED LINE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

RUSTING ORE TRAIN, ONCE PART OF NEW YORK ELEVATED LINE (TWO LOCOMOTIVES, SHOWING RAILROAD TRUCKS IN FOREGROUND) - Council City & Solomon River Railroad, Locomotives, Nome Vicinity, Nome, Nome Census Area, AK

33 CFR 167.154 - Off New York: South-eastern approach.

Code of Federal Regulations, 2014 CFR

2014-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.154 Off New York: South-eastern approach...

33 CFR 167.154 - Off New York: South-eastern approach.

Code of Federal Regulations, 2013 CFR

2013-07-01

... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.154 Off New York: South-eastern approach...

48 CFR 211.002 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... DEFENSE ACQUISITION PLANNING DESCRIBING AGENCY NEEDS 211.002 Policy. All defense technology and... System, and DoDI 5000.2, Operation of the Defense Acquisition System. [71 FR 27641, May 12, 2006] ...

77 FR 42507 - Notice of Inventory Completion: New York University College of Dentistry, New York, NY

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-19

... Inventory Completion: New York University College of Dentistry, New York, NY AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The New York University College of Dentistry has completed an inventory... the New York University College of Dentistry. Disposition of the human remains to the Indian tribes...

77 FR 42513 - Notice of Inventory Completion: New York University College of Dentistry, New York, NY

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-19

... Inventory Completion: New York University College of Dentistry, New York, NY AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The New York University College of Dentistry has completed an inventory... the New York University College of Dentistry. Disposition of the human remains to the Indian tribes...

77 FR 42508 - Notice of Inventory Completion: New York University College of Dentistry, New York, NY

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-19

... Inventory Completion: New York University College of Dentistry, New York, NY AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The New York University College of Dentistry has completed an inventory... the New York University College of Dentistry. Repatriation of the human remains to the Indian tribes...

IKK{epsilon} modulates RSV-induced NF-{kappa}B-dependent gene transcription

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bao Xiaoyong; Indukuri, Hemalatha; Liu Tianshuang

2010-12-20

Respiratory syncytial virus (RSV), a negative-strand RNA virus, is the most common cause of epidemic respiratory disease in infants and young children. RSV infection of airway epithelial cells induces the expression of immune/inflammatory genes through the activation of a subset of transcription factors, including Nuclear Factor-{kappa}B (NF-{kappa}B). In this study we have investigated the role of the non canonical I{kappa}B kinase (IKK){epsilon} in modulating RSV-induced NF-{kappa}B activation. Our results show that inhibition of IKK{epsilon} activation results in significant impairment of viral-induced NF-{kappa}B-dependent gene expression, through a reduction in NF-{kappa}B transcriptional activity, without changes in nuclear translocation or DNA-binding activity. Absencemore » of IKK{epsilon} results in a significant decrease of RSV-induced NF-{kappa}B phosphorylation on serine 536, a post-translational modification important for RSV-induced NF-{kappa}B-dependent gene expression, known to regulate NF-{kappa}B transcriptional activity without affecting nuclear translocation. This study identifies a novel mechanism by which IKK{epsilon} regulates viral-induced cellular signaling.« less

STS-36 night Earth observation of New York City, New York

NASA Image and Video Library

1990-03-03

STS-36 Earth observation shows New York City, New York at night lit up along the Eastern seaboard of the United States and the Atlantic Ocean. The city lights designate the densely populated central city and the major highways surrounding it.

New York Urban Hydro-Meteorological Testbed (NY-uHMT)

NASA Astrophysics Data System (ADS)

Norouzi, H.; Bah, A.

2017-12-01

It is well known that heat waves kill more persons, on average, than any other extreme weather event in the United States. New York City experiences much adversity due to inclement weather. Exploring climate variation in New Yorker City will help scientists and local government to detect and forecast extreme weather hazards and gather more localized temperature data within the five boroughs. Ground based weather stations are widely used to provide real time data to the public to prevent disasters. The New York urban Hydro-meteorological Testbed (NY-uHMT) is a hydro meteorological network that is used to investigate climate change in the New York City area. It is composed of twenty autonomous weather stations that will gather information on air temperature, relative humidity, rainfall and soil moisture properties around the densely populated NYC area. For each station, the data is stored on a Campbell Scientific CR200x data logger and can be accessed remotely using the LoggerNet software, or by direct connection using an RS-232 cable. Real-time weather data is acquired every fifteen minutes. The data is then periodically sampled and graphed through MATLAB code to be broadcasted on the uHMT website and is available at no charge to the public. We anticipate the results will show that the temperature, humidity, precipitation and soil moisture will vary from location to location depending on the magnitude of urbanization to the area.

75 FR 33329 - Notice of Inventory Completion: New York University College of Dentistry, New York, NY

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-11

... University College of Dentistry, New York, NY AGENCY: National Park Service, Interior. ACTION: Notice. Notice... the New York University College of Dentistry, New York, NY. The human remains were removed from.... A detailed assessment of the human remains was made by the New York University College of Dentistry...

MIGRANT FARM LABOR IN NEW YORK STATE.

ERIC Educational Resources Information Center

New York State Interdepartmental Committee on Farm and Food Processing Labor, Albany.

SEVEN NEW YORK STATE DEPARTMENTS WORK TOGETHER TO SEE THAT THE MIGRANT IS TREATED FAIRLY AND HUMANELY IN THE AREAS OF HEALTH, HOUSING, CHILD CARE, EDUCATION, LABOR CONDITIONS, SAFETY, AND EMPLOYER-EMPLOYEE RELATIONS. AN INTERDEPARTMENTAL COMMITTEE GUIDES THE EFFORTS OF THE DEPARTMENTS. THE AGENCIES WORK WITH A BODY OF STATE LAW WHICH IS UPDATED…

State Teacher Policy Yearbook, 2009. New York

ERIC Educational Resources Information Center

National Council on Teacher Quality, 2009

2009-01-01

The New York edition of the National Council on Teacher Quality's (NCTQ's) 2009 "State Teacher Policy Yearbook" is the third annual look at state policies impacting the teaching profession. It is hoped that this report will help focus attention on areas where state policymakers can make changes that will have a positive impact on teacher…

Inhibiting NF-κB Activation by Small Molecules As a Therapeutic Strategy

PubMed Central

Gupta, Subash C; Sundaram, Chitra; Reuter, Simone; Aggarwal, Bharat B

2010-01-01

Because nuclear factor-κB (NF-κB) is a ubiquitously expressed proinflammatory transcription factor that regulates the expression of over 500 genes involved in cellular transformation, survival, proliferation, invasion, angiogenesis, metastasis, and inflammation, the NF-κB signaling pathway has become a potential target for pharmacological intervention. A wide variety of agents can activate NF-κB through canonical and noncanonical pathways. Canonical pathway involves various steps including the phosphorylation, ubiquitnation, and degradation of the inhibitor of NF-κB (IκBα), which leads to the nuclear translocation of the p50- p65 subunits of NF-κB followed by p65 phosphorylation, acetylation and methylation, DNA binding, and gene transcription. Thus, agents that can inhibit protein kinases, protein phosphatases, proteasomes, ubiquitnation, acetylation, methylation, and DNA binding steps have been identified as NF-κB inhibitors. Here, we review the small molecules that suppress NF-κB activation and thus may have therapeutic potential. PMID:20493977

Histologic improvement in photodamage after 12 months of treatment with tretinoin emollient cream (0.02%).

PubMed

Kircik, Leon H

2012-09-01

Topical retinoids, such as tretinoin, have been established as the gold standard for the treatment of photodamaged skin. This was a single-center, open-label, single-group, observational histologic subanalysis of 3 of 19 patients participating in a study of the efficacy and safety of tretinoin emollient cream 0.02% for the treatment of moderate to severe facial photodamage. Subjects were female, 18 years of age or older, and instructed to apply tretinoin 0.02% to the treatment areas for 12 months. Histology was undertaken using facial photographs and 2-mm biopsies of the lateral canthus area that were obtained from 3 subjects at baseline and 12 months. Histopathologic analyses revealed evidence of extensive solar elastosis at baseline for 2 of the 3 subjects who were white, with moderate elastosis observed for the third subject who was African American. Histologic improvements in photodamage following 12 months of treatment with tretinoin 0.02% were observed for each subject. Improvements included smoothing of the epidermis, a slightly thinner keratin layer, and thin, comparatively straight elastic and collagen fibers in the mid- to deep-dermal layer. The histologic changes in all subjects could be attributed to a remodeling (elastin) or repair (collagen) process that affected the connective tissue fibers in all layers of the dermis. These results suggest that tretinoin 0.02% may be an effective treatment for photodamage, and additional evaluation is warranted in future studies.

Forest Statistics for New York 1980 and 1993

Treesearch

Carol L. Alerich; David A. Drake; David A. Drake

1995-01-01

A statistical report on the fourth forest inventory of New York 1991- 1994. Findings are displayed in 155 tables containing estimates of forest area numbers of trees wildlife habitat timber volume growth change and biomass. Data are presented at three levels; state, geographic unit, and county.

Drainage areas of New York streams, by river basins; a stream gazetteer; Part 1, Data compiled as of October 1980

USGS Publications Warehouse

Wagner, L.A.

1982-01-01

Hydrologic studies concerned with surface water require geographic data of several types, among which are stream length and size of drainage area from which runoff is contributed. This gazetteer presents all drainage-area data on New York streams that were available as of October 1980. The information is grouped by river basin, and each section consists of two lists. The first gives sites alphabetically by stream name and includes the body of water to which the stream is tributary, county in which the site is located, drainage area above the mouth, coordinates of the topographic quadrangle on the State index map , and the Geological Survey site number. The second list presents site information by U.S. Geological Survey site number (downstream order along the main stream) and includes drainage area, distance of measurement site above the mouth, and location by latitude and longitude. Data were compiled from published and unpublished sources, all of which are available for inspection at the U.S. Geological Survey in Albany, N.Y. Also included are updated values on several river basins that have been redelineated and whose drainage areas have been recomputed and retabulated since 1977. (USGS)

46 CFR 160.002-5 - Sampling, tests, and inspections.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 6 2011-10-01 2011-10-01 false Sampling, tests, and inspections. 160.002-5 Section 160.002-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND... Type), Models 3 and 5 § 160.002-5 Sampling, tests, and inspections. (a) Production tests and...

46 CFR 160.002-5 - Sampling, tests, and inspections.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 6 2010-10-01 2010-10-01 false Sampling, tests, and inspections. 160.002-5 Section 160.002-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND... Type), Models 3 and 5 § 160.002-5 Sampling, tests, and inspections. (a) Production tests and...

Orientia tsutsugamushi uses two Ank effectors to modulate NF-κB p65 nuclear transport and inhibit NF-κB transcriptional activation.

PubMed

Evans, Sean M; Rodino, Kyle G; Adcox, Haley E; Carlyon, Jason A

2018-05-01

Orientia tsutsugamushi causes scrub typhus, a potentially fatal infection that threatens over one billion people. Nuclear translocation of the transcription factor, NF-κB, is the central initiating cellular event in the antimicrobial response. Here, we report that NF-κB p65 nuclear accumulation and NF-κB-dependent transcription are inhibited in O. tsutsugamushi infected HeLa cells and/or primary macrophages, even in the presence of TNFα. The bacterium modulates p65 subcellular localization by neither degrading it nor inhibiting IκBα degradation. Rather, it exploits host exportin 1 to mediate p65 nuclear export, as this phenomenon is leptomycin B-sensitive. O. tsutsugamushi antagonizes NF-κB-activated transcription even when exportin 1 is inhibited and NF-κB consequently remains in the nucleus. Two ankyrin repeat-containing effectors (Anks), Ank1 and Ank6, each of which possess a C-terminal F-box and exhibit 58.5% amino acid identity, are linked to the pathogen's ability to modulate NF-κB. When ectopically expressed, both translocate to the nucleus, abrogate NF-κB-activated transcription in an exportin 1-independent manner, and pronouncedly reduce TNFα-induced p65 nuclear levels by exportin 1-dependent means. Flag-tagged Ank 1 and Ank6 co-immunoprecipitate p65 and exportin 1. Both also bind importin β1, a host protein that is essential for the classical nuclear import pathway. Importazole, which blocks importin β1 activity, abrogates Ank1 and Ank6 nuclear translocation. The Ank1 and Ank6 regions that bind importin β1 also mediate their transport into the nucleus. Yet, these regions are distinct from those that bind p65/exportin 1. The Ank1 and Ank6 F-box and the region that lies between it and the ankyrin repeat domain are essential for blocking p65 nuclear accumulation. These data reveal a novel mechanism by which O. tsutsugamushi modulates the activity and nuclear transport of NF-κB p65 and identify the first microbial proteins that co-opt both

Maximum known stages and discharges of New York streams and their annual exceedance probabilities through September 2011

USGS Publications Warehouse

Wall, Gary R.; Murray, Patricia M.; Lumia, Richard; Suro, Thomas P.

2014-01-01

Maximum known stages and discharges at 1,400 sites on 796 streams within New York are tabulated. Stage data are reported in feet. Discharges are reported as cubic feet per second and in cubic feet per second per square mile. Drainage areas range from 0.03 to 298,800 square miles; excluding the three sites with larger drainage areas on the St. Lawrence and Niagara Rivers, which drain the Great Lakes, the maximum drainage area is 8,288 square miles (Hudson River at Albany). Most data were obtained from U.S. Geological Survey (USGS) compilations and records, but some were provided by State, local, and other Federal agencies and by private organizations. The stage and discharge information is grouped by major drainage basins and U.S. Geological Survey site number, in downstream order. Site locations and their associated drainage area, period(s) of record, stage and discharge data, and flood-frequency statistics are compiled in a Microsoft Excel spreadsheet. Flood frequencies were derived for 1,238 sites by using methods described in Bulletin 17B (Interagency Advisory Committee on Water Data, 1982), Ries and Crouse (2002), and Lumia and others (2006). Curves that “envelope” maximum discharges within their range of drainage areas were developed for each of six flood-frequency hydrologic regions and for sites on Long Island, as well as for the State of New York; the New York curve was compared with a curve derived from a plot of maximum known discharges throughout the United States. Discharges represented by the national curve range from at least 2.7 to 4.9 times greater than those represented by the New York curve for drainage areas of 1.0 and 1,000 square miles. The relative magnitudes of discharge and runoff in the six hydrologic regions of New York and Long Island suggest the largest known discharges per square mile are in the southern part of western New York and the Catskill Mountain area, and the smallest are on Long Island.

A parapoxviral virion protein inhibits NF-κB signaling early in infection

PubMed Central

Khatiwada, Sushil; Delhon, Gustavo; Nagendraprabhu, Ponnuraj; Chaulagain, Sabal; Luo, Shuhong; Diel, Diego G.; Flores, Eduardo F.

2017-01-01

Poxviruses have evolved unique proteins and mechanisms to counteract the nuclear factor κB (NF-κB) signaling pathway, which is an essential regulatory pathway of host innate immune responses. Here, we describe a NF-κB inhibitory virion protein of orf virus (ORFV), ORFV073, which functions very early in infected cells. Infection with ORFV073 gene deletion virus (OV-IA82Δ073) led to increased accumulation of NF-κB essential modulator (NEMO), marked phosphorylation of IκB kinase (IKK) subunits IKKα and IKKβ, IκBα and NF-κB subunit p65 (NF-κB-p65), and to early nuclear translocation of NF-κB-p65 in virus-infected cells (≤ 30 min post infection). Expression of ORFV073 alone was sufficient to inhibit TNFα induced activation of the NF-κB signaling in uninfected cells. Consistent with observed inhibition of IKK complex activation, ORFV073 interacted with the regulatory subunit of the IKK complex NEMO. Infection of sheep with OV-IA82Δ073 led to virus attenuation, indicating that ORFV073 is a virulence determinant in the natural host. Notably, ORFV073 represents the first poxviral virion-associated NF-κB inhibitor described, highlighting the significance of viral inhibition of NF-κB signaling very early in infection. PMID:28787456

NF1 Signal Transduction and Vascular Dysfunction

DTIC Science & Technology

2015-05-01

microenvironment that promotes much of the pathology associated with the disease . Moreover we hypothesize that a mechanistic consequence of the loss...obliteration of the normal red pulp architecture. In addition, we found significant peri-aveolar and peri-vascular inflammatory infiltrates in the lung...the mouse model of NF1 disease in the endothelium we proposed and have done experiments investigating the loss of endothelial NF1 in the adult

Frequent NF2 gene transcript mutations in sporadic meningiomas and vestibular schwannomas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deprez, R.H.L.; Groen, N.A.; Zwarthoff, E.C.

1994-06-01

The gene for the hereditary disorder neurofibromatosis type 2 (NF2), which predisposes for benign CNS tumors such as vestibular schwannomas and meningiomas, has been assigned to chromosome 22 and recently has been isolated. Mutations in the NF2 gene were found in both sporadic meningiomas and vestibular schwannomas. However, so far only 6 of the 16 exons of the gene have been analyzed. In order to extend the analysis of an involvement of the NF2 gene in the sporadic counterparts of these NF2-related tumors, the authors have used reverse transcriptase-PCR amplification followed by SSCP and DNA sequence analysis to screen formore » mutations in the coding region of the NF2 gene. Analysis of the NF2 gene transcript in 53 unrelated patients with meningiomas and vestibular schwannomas revealed mutations in 32% of the sporadic meningiomas (n = 44), in 50% of the sporadic vestibular schwannomas (n = 4), in 100% of the tumors found in NF2 patients (n = 2), and in one of three tumors from multiple-meningioma patients. Of the 18 tumors in which a mutation in the NF2 gene transcript was observed and the copy number of chromosome 22 could be established, 14 also showed loss of (parts of) chromosome 22. This suggests that in sporadic meningiomas and NF2-associated tumors the NF2 gene functions as a recessive tumor-suppressor gene. The mutations detected resulted mostly in frameshifts, predicting truncations starting within the N-terminal half of the putative protein. 23 refs., 2 figs. 3 tabs.« less

Leading and Managing Today's Independent School: A Qualitative Analysis of the Skills and Practices of Experienced Heads of Independent Schools in the New York Metropolitan Area

ERIC Educational Resources Information Center

Juhel, Jean-Marc

2016-01-01

This article presents the findings of a qualitative study conducted in 2014 with 16 experienced heads of school in the New York metropolitan area. The study was designed to better understand the skills and practices that they view as critical to leading and managing independent schools. The data collected speak to each head's ability to manage the…

Characterizing Myeloid Cell Activation in NF1 Vasculopathy

DTIC Science & Technology

2016-07-01

mechanistic insight and develop therapeutic targets for the prevention/treatment of neurofibromatosis type 1 (NF1) related cardiovascular disease ...therapeutic targets for the prevention/treatment of neurofibromatosis type 1 (NF1) related cardiovascular diseases . Cardiovascular disease affects upwards...superoxide; macrophages; monocytes; arteries; cardiovascular disease Major Goals and Accomplishments: Significant progress toward accomplishing

Pre-folding IkappaBalpha alters control of NF-kappaB signaling.

PubMed

Truhlar, Stephanie M E; Mathes, Erika; Cervantes, Carla F; Ghosh, Gourisankar; Komives, Elizabeth A

2008-06-27

Transcription complex components frequently show coupled folding and binding but the functional significance of this mode of molecular recognition is unclear. IkappaBalpha binds to and inhibits the transcriptional activity of NF-kappaB via its ankyrin repeat (AR) domain. The beta-hairpins in ARs 5-6 in IkappaBalpha are weakly-folded in the free protein, and their folding is coupled to NF-kappaB binding. Here, we show that introduction of two stabilizing mutations in IkappaBalpha AR 6 causes ARs 5-6 to fold cooperatively to a conformation similar to that in NF-kappaB-bound IkappaBalpha. Free IkappaBalpha is degraded by a proteasome-dependent but ubiquitin-independent mechanism, and this process is slower for the pre-folded mutants both in vitro and in cells. Interestingly, the pre-folded mutants bind NF-kappaB more weakly, as shown by both surface plasmon resonance and isothermal titration calorimetry in vitro and immunoprecipitation experiments from cells. One consequence of the weaker binding is that resting cells containing these mutants show incomplete inhibition of NF-kappaB activation; they have significant amounts of nuclear NF-kappaB. Additionally, the weaker binding combined with the slower rate of degradation of the free protein results in reduced levels of nuclear NF-kappaB upon stimulation. These data demonstrate clearly that the coupled folding and binding of IkappaBalpha is critical for its precise control of NF-kappaB transcriptional activity.

48 CFR 5.002 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

....002 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING... (c) Assist small business concerns, veteran-owned small business concerns, service-disabled veteran-owned small business concerns, HUBZone small business concerns, small disadvantaged business concerns...

An analysis of New York's timber resources

Treesearch

Thomas J., Jr. Considine

1984-01-01

This report presents an analysis of the results of the third forest survey of New York as well as trends that have occurred since the previous surveys. Topics include forest area by ownership, stand size, and forest type; timber volume by species, location, and quality; biomass; timber products output for sawlogs, pulpwood, and fuelwood; and growth and removals. Forest...

Basement flooding and foundation damage from water-table rise in the East New York section of Brooklyn, Long Island, New York

USGS Publications Warehouse

Soren, Julian

1976-01-01

A rising water table following cessation of public-supply pumping has been causing basement flooding and building-foundation damage in the East New York section of Brooklyn, Kings County, Long Island, N.Y., since 1975. The water table in the central part of the area rose from a low of about 12 feet (3.7 meters) below sea level in 1936 to about 8 to 10 feet (2.4 to 3 meters) above sea level in March 1976. Public-supply pumping in Brooklyn ceased in 1947 and ceased in 1974 in the adjacent Woodhaven section of Queens County. A further water-table rise of about 2 feet (0.6 meter) is anticipated in the next several years in the central part of the East New York area, and the ultimate water-table height could be as much as about 15 feet (4.6 meters) above sea level. Relief from the flooding by dewatering operations is complicated by problems with disposal of pumped-out ground water. (Woodard-USGS)

Porcine arterivirus activates the NF-{kappa}B pathway through I{kappa}B degradation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Sang-Myeong; Kleiboeker, Steven B.

2005-11-10

Nuclear factor-kappaB (NF-{kappa}B) is a critical regulator of innate and adaptive immune function as well as cell proliferation and survival. The present study demonstrated for the first time that a virus belonging to the Arteriviridae family activates NF-{kappa}B in MARC-145 cells and alveolar macrophages. In porcine reproductive and respiratory syndrome virus (PRRSV)-infected cells, NF-{kappa}B activation was characterized by translocation of NF-{kappa}B from the cytoplasm to the nucleus, increased DNA binding activity, and NF-{kappa}B-regulated gene expression. NF-{kappa}B activation was increased as PRRSV infection progressed and in a viral dose-dependent manner. UV-inactivation of PRRSV significantly reduced the level of NF-{kappa}B activation. Degradationmore » of I{kappa}B protein was detected late in PRRSV infection, and overexpression of the dominant negative form of I{kappa}B{alpha} (I{kappa}B{alpha}DN) significantly suppressed NF-{kappa}B activation induced by PRRSV. However, I{kappa}B{alpha}DN did not affect viral replication and viral cytopathic effect. PRRSV infection induced oxidative stress in cells by generating reactive oxygen species (ROS), and antioxidants inhibited NF-{kappa}B DNA binding activity in PRRSV-infected cells, suggesting ROS as a mechanism by which NF-{kappa}B was activated by PRRSV infection. Moreover, NF-{kappa}B-dependent expression of matrix metalloproteinase (MMP)-2 and MMP-9 was observed in PRRSV-infected cells, an observation which implies that NF-{kappa}B activation is a biologically significant aspect of PRRSV pathogenesis. The results presented here provide a basis for understanding molecular pathways of pathology and immune evasion associated with disease caused by PRRSV.« less

Potent Anti-Inflammatory Activity of Ursolic Acid, a Triterpenoid Antioxidant, Is Mediated through Suppression of NF-κB, AP-1 and NF-AT

PubMed Central

Checker, Rahul; Sandur, Santosh K.; Sharma, Deepak; Patwardhan, Raghavendra S.; Jayakumar, S.; Kohli, Vineet; Sethi, Gautam; Aggarwal, Bharat B.; Sainis, Krishna B.

2012-01-01

Background Ursolic acid (UA), a pentacyclic triterpenoid carboxylic acid, is the major component of many plants including apples, basil, cranberries, peppermint, rosemary, oregano and prunes and has been reported to possess antioxidant and anti-tumor properties. These properties of UA have been attributed to its ability to suppress NF-κB (nuclear factor kappa B) activation. Since NF-κB, in co-ordination with NF-AT (nuclear factor of activated T cells) and AP-1(activator protein-1), is known to regulate inflammatory genes, we hypothesized that UA might exhibit potent anti-inflammatory effects. Methodology/Principal Findings The anti-inflammatory effects of UA were assessed in activated T cells, B cells and macrophages. Effects of UA on ERK, JNK, NF-κB, AP-1 and NF-AT were studied to elucidate its mechanism of action. In vivo efficacy of UA was studied using mouse model of graft-versus-host disease. UA inhibited activation, proliferation and cytokine secretion in T cells, B cells and macrophages. UA inhibited mitogen-induced up-regulation of activation markers and co-stimulatory molecules in T and B cells. It inhibited mitogen-induced phosphorylation of ERK and JNK and suppressed the activation of immunoregulatory transcription factors NF-κB, NF-AT and AP-1 in lymphocytes. Treatment of cells with UA prior to allogenic transplantation significantly delayed induction of acute graft-versus-host disease in mice and also significantly reduced the serum levels of pro-inflammatory cytokines IL-6 and IFN-γ. UA treatment inhibited T cell activation even when added post-mitogenic stimulation demonstrating its therapeutic utility as an anti-inflammatory agent. Conclusions/Significance The present study describes the detailed mechanism of anti-inflammatory activity of UA. Further, UA may find application in the treatment of inflammatory disorders. PMID:22363615

Is the high ischemic heart disease mortality rate in New York State just an urban effect?

PubMed Central

McNutt, L A; Strogatz, D S; Coles, F B; Fehrs, L J

1994-01-01

To determine whether New York State's high ischemic heart disease mortality rate was due primarily to an urban effect, rates for regions in the State were compared with each other and with national data. New York State mortality rates for the period 1980-87 were highest for New York City (344.5 per 100,000 residents), followed by upstate urban and rural areas (267.1-285.1), and New York City suburbs (272.5). However, the overall 1986 age-adjusted rate for the New York State region with the lowest mortality rate (265.7) exceeded that of 42 States. New York State's number one ischemic heart disease mortality ranking reflects the need for statewide intervention programs, because even regions with relatively low mortality rates are high when they are compared with national rates. PMID:8041858

Artemisia princeps Pamp. Essential oil and its constituents eucalyptol and α-terpineol ameliorate bacterial vaginosis and vulvovaginal candidiasis in mice by inhibiting bacterial growth and NF-κB activation.

PubMed

Trinh, Hien-Trung; Lee, In-Ah; Hyun, Yang-Jin; Kim, Dong-Hyun

2011-12-01

To investigate the inhibitory effects of Artemisia princeps Pamp. (family Asteraceae) essential oil (APEO) and its main constituents against bacterial vaginosis and vulvovaginal candidiasis, their antimicrobial activities against Gardnerella vaginalis and Candida albicans in vitro and their anti-inflammatory effects against G. vaginalis-induced vaginosis and vulvovaginal candidiasis were examined in mice. APEO and its constituents eucalyptol and α-terpineol were found to inhibit microbe growths. α-Terpineol most potently inhibited the growths of G. vaginalis and C. albicans with MIC values of 0.06 and 0.125 % (v/v), respectively. The antimicrobial activity of α-terpineol was found to be comparable to that of clotrimazole. Intravaginal treatment with APEO, eucalyptol, or α-terpineol significantly decreased viable G. vaginalis and C. albicans numbers in the vaginal cavity and myeloperoxidase activity in mouse vaginal tissues compared with controls. These agents also inhibited the expressions of proinflammatory cytokines (IL-1 β, IL-6, TNF- α), COX-2, iNOS, and the activation of NF- κB and increased expression of the anti-inflammatory cytokine IL-10. In addition, they inhibited the expressions of proinflammatory cytokines and the activation of NF- κB in lipopolysaccharide-stimulated peritoneal macrophages, and α-terpineol most potently inhibited the expressions of proinflammatory cytokines and NF- κB activation. Based on these findings, APEO and its constituents, particularly α-terpineol, ameliorate bacterial vaginosis and vulvovaginal candidiasis by inhibiting the growths of vaginal pathogens and the activation of NF- κB. © Georg Thieme Verlag KG Stuttgart · New York.

48 CFR 923.002 - Policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 923.002 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE... Federal Environmental, Energy and Transportation Management, require contracts for the operation of...

48 CFR 923.002 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 923.002 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE... Federal Environmental, Energy and Transportation Management, require contracts for the operation of...

48 CFR 923.002 - Policy.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 923.002 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE... Federal Environmental, Energy and Transportation Management, require contracts for the operation of...

48 CFR 923.002 - Policy.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 923.002 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE... Federal Environmental, Energy and Transportation Management, require contracts for the operation of...

Therapeutic microRNAs targeting the NF-kappa B Signaling Circuits of Cancers

PubMed Central

Tong, Lingying; Yuan, Ye; Wu, Shiyong

2014-01-01

MicroRNAs (miRNAs) not only directly regulate NF-κB expression, but also up- or down-regulate NF-κB activity via upstream and downstream signaling pathways of NF-κB. In many cancer cells, miRNA expressions are altered accompanied with an elevation of NF-κB, which often plays a role in promoting cancer development and progression as well as hindering the effectiveness of chemo and radiation therapies. Thus NF-κB-targeting miRNAs have been identified and characterized as potential therapeutics for cancer treatment and sensitizers of chemo and radiotherapies. However, due to cross-targeting and instability of miRNAs, some limitations of using miRNA as cancer therapeutics still exist. In this review, the mechanisms for miRNA-mediated alteration of NF-κB expression and activation in different types of cancers will be discussed. The results of therapeutic use of NF-κB-targeting miRNA for cancer treatment will be examined. Some limitations, challenges and potential strategies in future development of miRNA as cancer therapeutics are also assessed. PMID:25220353

New York City, New York Municipal Forest Resource Analysis

Treesearch

P.J. Peper; E.G. McPherson; J.R. Simpson; S.L. Gardner; K.E. Vargas; Q. Xiao

2007-01-01

New York City, the largest city in the United States and one of the world’s major global cities, main-tains trees as an integral component of the urban infrastructure (Figure 1). Since 1995, over 120,000 trees have been planted along the streets of the city’s five boroughs. Over 592,000 street trees are managed by the New York City Department of Parks & Recreation...

77 FR 42510 - Notice of Inventory Completion: New York University College of Dentistry, New York, NY; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-19

... Inventory Completion: New York University College of Dentistry, New York, NY; Correction AGENCY: National... of human remains under the control of the New York University College of Dentistry, New York, NY. The... Dentistry professional staff in consultation with representatives of the Delaware Nation of Oklahoma...

The Handwriting Performance of Children with NF1

ERIC Educational Resources Information Center

Gilboa, Yafit; Josman, Naomi; Fattal-Valevski, Aviva; Toledano-Alhadef, Hagit; Rosenblum, Sara

2010-01-01

The objective of this study was to analyze the process and product of handwriting among children with Neurofibromatosis Type 1 (NF1) in comparison to those of Typically Developing (TD) children. Children with NF1 are at risk for some cognitive deficits, a wide range of deficits in perceptual skills and, motor and visual-motor integration skills…

NF-1 Dependent Gene Regulation in Drosophila Melanogaster

DTIC Science & Technology

2004-04-01

standard cornmeal medium at 25oC in a humidified incubator. Flies were collected and frozen in liquid nitrogen at the same time of day to minimize...melanogaster media, strains and heat-shock conditions Flies were raised at room temperature (22–248C) on standard cornmeal medium. The Nf1 mutants Nf1P1 and

NF-kappaB mediates FGF signal regulation of msx-1 expression.

PubMed

Bushdid, P B; Chen, C L; Brantley, D M; Yull, F; Raghow, R; Kerr, L D; Barnett, J V

2001-09-01

The nuclear factor-kappaB (NF-kappaB) family of transcription factors is involved in proliferation, differentiation, and apoptosis in a stage- and cell-dependent manner. Recent evidence has shown that NF-kappaB activity is necessary for both chicken and mouse limb development. We report here that the NF-kappaB family member c-rel and the homeodomain gene msx-1 have partially overlapping expression patterns in the developing chick limb. In addition, inhibition of NF-kappaB activity resulted in a decrease in msx-1 mRNA expression. Sequence analysis of the msx-1 promoter revealed three potential kappaB-binding sites similar to the interferon-gamma (IFN-gamma) kappaB-binding site. These sites bound to c-Rel, as shown by electrophoretic mobility shift assay (EMSA). Furthermore, inhibition of NF-kappaB activity significantly reduced transactivation of the msx-1 promoter in response to FGF-2/-4, known stimulators of msx-1 expression. These results suggest that NF-kappaB mediates the FGF-2/-4 signal regulation of msx-1 gene expression. Copyright 2001 Academic Press.

Expression of NF-κB and PTEN in osteosarcoma and its clinical significance

PubMed Central

Gong, Teng; Su, Xuetao; Xia, Qun; Wang, Jinggui; Kan, Shilian

2017-01-01

We investigated the role of nuclear factor-κB (NF-κB) and phosphatase and tensin homolog deleted in chromosome 10 (PTEN) in the pathogenesis of osteosarcoma and its relationship with prognosis. Immunohistochemical method was used to detect the expression of NF-κB and PTEN in osteosarcoma and adjacent tissues. RT-PCR was used to detect the expression of NF-κB and PTEN mRNA in osteosarcoma and adjacent tissues. Western blotting was used to detect the expression of NF-κB and PTEN in osteosarcoma and adjacent tissues and compare their differences. The expression of NF-κB and PTEN was detected in osteosarcoma and adjacent tissues. The positive rate of NF-κB was 75.3 and 32.9%, respectively; while the positive rate of PTEN was 67.1 and 90.4%, respectively. The positive expression of NF-κB and PTEN was statistically significant. There was a negative correlation between NF-κB and PTEN expression (r=−0.502, p<0.05). The positive and negative expression of NF-κB and PTEN was statistically significant for the five-year survival (p<0.05). At gene and protein level, osteosarcoma tissues had higher expression of NF-κB, and lower expression of PTEN, which was significantly different from the adjacent tissues. In osteosarcoma, NF-κB is highly expressed, but PTEN is expressed at low level, and the two are negatively correlated. This is of great significance for the early diagnosis of osteosarcoma and prognosis. PMID:29151913

Police deaths in New York and London during the twentieth century

PubMed Central

Kyriacou, D N; Monkkonen, E H; Peek‐Asa, C; Lucke, R E; Labbett, S; Pearlman, K S; Hutson, H R

2006-01-01

Objectives To describe the incidences and causes of occupational police deaths in New York City in the United States and Greater London in the United Kingdom during the twentieth century. To assess the relation between overall societal violence and violence directed toward police officers in these metropolitan areas. Design and setting Ecological study of New York and London from 1900 through 1999. Main outcome measures Intentional and unintentional occupational police mortality rates for New York and London were estimated for each decade. The general population homicide rates of both New York and London were assessed for their correlation with their respective intentional occupational police mortality rates. Results During the 20th century, 585 police officers in New York and 160 police officers in London died while participating in law enforcement activities. New York had markedly greater intentional police mortality rates compared to London throughout most of the 20th century, but these differences decreased significantly by the end of the century. Intentional gunshot wounds comprised 290 police deaths in New York, but only 14 police deaths in London. In New York, gun shot wounds (both intentional and unintentional) accounted for more occupational police deaths (51.6%) than did all other injury mechanisms combined. In London, motor vehicle collision was the most common cause (47.5%) of occupational police death. There were no apparent correlations between the general population homicide rates and intentional police mortality rates in either New York (r2 = 0.05, 95% CI −0.77 to 0.81) or London (r2 = 0.34, 95% CI −0.61 to 0.89). Conclusions During the 20th century, both intentional and unintentional occupational police mortality rates were significantly greater in New York compared to London. These differences are likely from several socioeconomic, cultural, and occupational factors. The declines in police deaths in New York during the latter part of

48 CFR 705.002 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 705.002 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT ACQUISITION... and Related Services Questionnaire; or USAID Form 1420-50, USAID Consultant Registry Information... Business Utilization (Department of State, U.S. Agency for International Development, Washington, DC 20523...

48 CFR 705.002 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 705.002 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT ACQUISITION... and Related Services Questionnaire; or USAID Form 1420-50, USAID Consultant Registry Information... Business Utilization (Department of State, U.S. Agency for International Development, Washington, DC 20523...

Integrating technical rock climbing into protected area management: a case example of Minnewaska State Park Preserve, New York State

Treesearch

Jennifer A. Cairo; Thomas L. Cobb

1998-01-01

In the fall of 1996, technical rock climbing was introduced as a regulated outdoor recreation activity in Minnewaska State Park Preserve, situated in the Shawangunk Mountain region of New York State. It is the first instance in which rock climbing has been sanctioned by the New York State Office of Parks, Recreation and Historic Preservation. This paper identifies key...

33 CFR 167.152 - Off New York: Eastern approach, off Nantucket.

Code of Federal Regulations, 2012 CFR

2012-07-01

... HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.152 Off New York: Eastern...

33 CFR 167.152 - Off New York: Eastern approach, off Nantucket.

Code of Federal Regulations, 2013 CFR

2013-07-01

... HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.152 Off New York: Eastern...

33 CFR 167.152 - Off New York: Eastern approach, off Nantucket.

Code of Federal Regulations, 2011 CFR

2011-07-01

... HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.152 Off New York: Eastern...

33 CFR 167.152 - Off New York: Eastern approach, off Nantucket.

Code of Federal Regulations, 2010 CFR

2010-07-01

... HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.152 Off New York: Eastern...

33 CFR 167.152 - Off New York: Eastern approach, off Nantucket.

Code of Federal Regulations, 2014 CFR

2014-07-01

... HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.152 Off New York: Eastern...

Human papillomavirus type 16 E6 and E 7 proteins alter NF-kB in cultured cervical epithelial cells and inhibition of NF-kB promotes cell growth and immortalization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vandermark, Erik R.; Deluca, Krysta A.; Gardner, Courtney R.

2012-03-30

The NF-kB family of transcription factors regulates important biological functions including cell growth, survival and the immune response. We found that Human Papillomavirus type 16 (HPV-16) E7 and E6/E7 proteins inhibited basal and TNF-alpha-inducible NF-kB activity in human epithelial cells cultured from the cervical transformation zone, the anatomic region where most cervical cancers develop. In contrast, HPV-16 E6 regulated NF-kB in a cell type- and cell growth-dependent manner. NF-kB influenced immortalization of cervical cells by HPV16. Inhibition of NF-kB by an IkB alpha repressor mutant increased colony formation and immortalization by HPV-16. In contrast, activation of NF-kB by constitutive expressionmore » of p65 inhibited proliferation and immortalization. Our results suggest that inhibition of NF-kB by HPV-16 E6/E7 contributes to immortalization of cells from the cervical transformation zone.« less

Meta-Analysis Identifies NF-κB as a Therapeutic Target in Renal Cancer

PubMed Central

Peri, Suraj; Devarajan, Karthik; Yang, Dong-Hua; Knudson, Alfred G.; Balachandran, Siddharth

2013-01-01

Objective To determine the expression patterns of NF-κB regulators and target genes in clear cell renal cell carcinoma (ccRCC), their correlation with von Hippel Lindau (VHL) mutational status, and their association with survival outcomes. Methods Meta-analyses were carried out on published ccRCC gene expression datasets by RankProd, a non-parametric statistical method. DEGs with a False Discovery Rate of < 0.05 by this method were considered significant, and intersected with a curated list of NF-κB regulators and targets to determine the nature and extent of NF-κB deregulation in ccRCC. Results A highly-disproportionate fraction (~40%; p < 0.001) of NF-κB regulators and target genes were found to be up-regulated in ccRCC, indicative of elevated NF-κB activity in this cancer. A subset of these genes, comprising a key NF-κB regulator (IKBKB) and established mediators of the NF-κB cell-survival and pro-inflammatory responses (MMP9, PSMB9, and SOD2), correlated with higher relative risk, poorer prognosis, and reduced overall patient survival. Surprisingly, levels of several interferon regulatory factors (IRFs) and interferon target genes were also elevated in ccRCC, indicating that an ‘interferon signature’ may represent a novel feature of this disease. Loss of VHL gene expression correlated strongly with the appearance of NF-κB- and interferon gene signatures in both familial and sporadic cases of ccRCC. As NF-κB controls expression of key interferon signaling nodes, our results suggest a causal link between VHL loss, elevated NF-κB activity, and the appearance of an interferon signature during ccRCC tumorigenesis. Conclusions These findings identify NF-κB and interferon signatures as clinical features of ccRCC, provide strong rationale for the incorporation of NF-κB inhibitors and/or and the exploitation of interferon signaling in the treatment of ccRCC, and supply new NF-κB targets for potential therapeutic intervention in this currently

75 FR 34923 - General Schedule Locality Pay Areas

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-21

...;Prices of new books are listed in the first FEDERAL REGISTER issue of each #0;week. #0; #0; #0; #0;#0... area to the New York locality pay area. We received no comments on the interim rule and adopt the final... Philadelphia locality pay area while Lakehurst, in Ocean County, New Jersey, was in the New York locality pay...

A glimpse at New York's current timber resource

Treesearch

Joseph E. Barnard; Teresa M. Bowers

1969-01-01

Data from the recent Forest Survey of New York reveal a 13-percent increase in commercial forest land area, a 12-percent increase in the cubic-foot volume of growing stock, and a 4-percent decrease in the board-foot volume of growing stock during the 18-year period between surveys.

An Update on Neurofibromatosis Type 1: Not Just Café-au-Lait Spots and Freckling. Part II. Other Skin Manifestations Characteristic of NF1. NF1 and Cancer.

PubMed

Hernández-Martín, A; Duat-Rodríguez, A

2016-01-01

Neurofibromatosis type 1 (NF1) is the most common neurocutaneous syndrome and probably the one best known to dermatologists. Although the genetic locus of NF1 was identified on chromosome 17 in 1987, diagnosis of the disease is still based primarily on clinical observations. The 7 diagnostic criteria of the National Institutes of Health, which were established in 1988, include 3 skin manifestations (café-au-lait spots, freckling on flexural areas, and cutaneous neurofibromas). The age at which these diagnostic lesions appear is variable: onset can be late in some patients while others never develop certain symptoms. Definitive diagnosis may therefore be delayed by years. Although the appearance of the characteristic café-au-lait spots and freckling in the early years of childhood are very suggestive of the disease, these signs are not pathognomonic and, in isolation, do not constitute sufficient evidence to establish a definitive diagnosis. Thus, other diagnoses should be considered in patients whose only symptoms are café-au-lait spots and freckling. By contrast, the presence of multiple cutaneous neurofibromas or at least 1 plexiform neurofibroma is a very specific indication of NF1. Identification of the different types of neurofibroma allows us to confirm the diagnosis and initiate appropriate management. Copyright © 2016 AEDV. Published by Elsevier España, S.L.U. All rights reserved.

Genome-wide identification and characterization of the NF-Y gene family in grape (vitis vinifera L.).

PubMed

Ren, Chong; Zhang, Zhan; Wang, Yi; Li, Shaohua; Liang, Zhenchang

2016-08-11

Nuclear factor Y (NF-Y) transcription factor is composed of three distinct subunits: NF-YA, NF-YB and NF-YC. Many members of NF-Y family have been reported to be key regulators in plant development, phytohormone signaling and drought tolerance. However, the function of the NF-Y family is less known in grape (Vitis vinifera L.). A total of 34 grape NF-Y genes that distributed unevenly on grape (V. vinifera) chromosomes were identified in this study. Phylogenetic analysis was performed to predict functional similarities between Arabidopsis thaliana and grape NF-Y genes. Comparison of the structures of grape NF-Y genes (VvNF-Ys) revealed their functional conservation and alteration. Furthermore, we investigated the expression profiles of VvNF-Ys in response to various stresses, phytohormone treatments, and in leaves and grape berries with various sugar contents at different developmental stages. The relationship between VvNF-Y transcript levels and sugar content was examined to select candidates for exogenous sugar treatments. Quantitative real-time PCR (qPCR) indicated that many VvNF-Ys responded to different sugar stimuli with variations in transcript abundance. qPCR and publicly available microarray data suggest that VvNF-Ys exhibit distinct expression patterns in different grape organs and developmental stages, and a number of VvNF-Ys may participate in responses to multiple abiotic and biotic stresses, phytohormone treatments and sugar accumulation or metabolism. In this study, we characterized 34 VvNF-Ys based on their distributions on chromosomes, gene structures, phylogenetic relationship with Arabidopsis NF-Y genes, and their expression patterns. The potential roles of VvNF-Ys in sugar accumulation or metabolism were also investigated. Altogether, the data provide significant insights on VvNF-Ys, and lay foundations for further functional studies of NF-Y genes in grape.

48 CFR 47.002 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-10-01

... transportation. (e) The making and administration of contracts under which payments are made from Government... TRANSPORTATION 47.002 Applicability. All Government personnel concerned with the following activities shall... transportation and transportation-related services. (c) Transportation assistance and traffic management. (d...

48 CFR 47.002 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-10-01

... transportation. (e) The making and administration of contracts under which payments are made from Government... TRANSPORTATION 47.002 Applicability. All Government personnel concerned with the following activities shall... transportation and transportation-related services. (c) Transportation assistance and traffic management. (d...

The Influenza A Virus Genotype Determines the Antiviral Function of NF-κB.

PubMed

Dam, Sharmistha; Kracht, Michael; Pleschka, Stephan; Schmitz, M Lienhard

2016-09-01

The role of NF-κB in influenza A virus (IAV) infection does not reveal a coherent picture, as pro- and also antiviral functions of this transcription factor have been described. To address this issue, we used clustered regularly interspaced short palindromic repeat with Cas9 (CRISPR-Cas9)-mediated genome engineering to generate murine MLE-15 cells lacking two essential components of the NF-κB pathway. Cells devoid of either the central NF-κB essential modulator (NEMO) scaffold protein and thus defective in IκB kinase (IKK) activation or cells not expressing the NF-κB DNA-binding and transactivation subunit p65 were tested for propagation of the SC35 virus, which has an avian host range, and its mouse-adapted variant, SC35M. While NF-κB was not relevant for replication of SC35M, the absence of NF-κB activity increased replication of the nonadapted SC35 virus. This antiviral effect of NF-κB was most prominent upon infection of cells with low virus titers as they usually occur during the initiation phase of IAV infection. The defect in NF-κB signaling resulted in diminished IAV-triggered phosphorylation of interferon regulatory factor 3 (IRF3) and expression of the antiviral beta interferon (IFN-β) gene. To identify the viral proteins responsible for NF-κB dependency, reassortant viruses were generated by reverse genetics. SC35 viruses containing the SC35M segment encoding neuraminidase (NA) were completely inert to the inhibitory effect of NF-κB, emphasizing the importance of the viral genotype for susceptibility to the antiviral functions of NF-κB. This study addresses two different issues. First, we investigated the role of the host cell transcription factor NF-κB in IAV replication by genetic manipulation of IAVs by reverse genetics combined with targeted genome engineering of host cells using CRISPR-Cas9. The analysis of these two highly defined genetic systems indicated that the IAV genotype can influence whether NF-κB displays an antiviral

The Influenza A Virus Genotype Determines the Antiviral Function of NF-κB

PubMed Central

Dam, Sharmistha; Kracht, Michael; Pleschka, Stephan

2016-01-01

ABSTRACT The role of NF-κB in influenza A virus (IAV) infection does not reveal a coherent picture, as pro- and also antiviral functions of this transcription factor have been described. To address this issue, we used clustered regularly interspaced short palindromic repeat with Cas9 (CRISPR-Cas9)-mediated genome engineering to generate murine MLE-15 cells lacking two essential components of the NF-κB pathway. Cells devoid of either the central NF-κB essential modulator (NEMO) scaffold protein and thus defective in IκB kinase (IKK) activation or cells not expressing the NF-κB DNA-binding and transactivation subunit p65 were tested for propagation of the SC35 virus, which has an avian host range, and its mouse-adapted variant, SC35M. While NF-κB was not relevant for replication of SC35M, the absence of NF-κB activity increased replication of the nonadapted SC35 virus. This antiviral effect of NF-κB was most prominent upon infection of cells with low virus titers as they usually occur during the initiation phase of IAV infection. The defect in NF-κB signaling resulted in diminished IAV-triggered phosphorylation of interferon regulatory factor 3 (IRF3) and expression of the antiviral beta interferon (IFN-β) gene. To identify the viral proteins responsible for NF-κB dependency, reassortant viruses were generated by reverse genetics. SC35 viruses containing the SC35M segment encoding neuraminidase (NA) were completely inert to the inhibitory effect of NF-κB, emphasizing the importance of the viral genotype for susceptibility to the antiviral functions of NF-κB. IMPORTANCE This study addresses two different issues. First, we investigated the role of the host cell transcription factor NF-κB in IAV replication by genetic manipulation of IAVs by reverse genetics combined with targeted genome engineering of host cells using CRISPR-Cas9. The analysis of these two highly defined genetic systems indicated that the IAV genotype can influence whether NF-κB displays

78 FR 29364 - Independent Power Producers of New York, Inc. v. New York Independent System Operator, Inc.

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-20

... Power Producers of New York, Inc. v. New York Independent System Operator, Inc. Notice of Complaint Take notice that on May 10, 2013, Independent Power Producers of New York, Inc. (IPPNY or Complainant) filed a complaint against New York Independent System Operator, Inc. (NYISO or Respondent), pursuant to [[Page 29365...

NF-κB gene signature predicts prostate cancer progression

PubMed Central

Jin, Renjie; Yi, Yajun; Yull, Fiona E.; Blackwell, Timothy S.; Clark, Peter E.; Koyama, Tatsuki; Smith, Joseph A.; Matusik, Robert J.

2014-01-01

In many prostate cancer (PCa) patients, the cancer will be recurrent and eventually progress to lethal metastatic disease after primary treatment, such as surgery or radiation therapy. Therefore, it would be beneficial to better predict which patients with early-stage PCa would progress or recur after primary definitive treatment. In addition, many studies indicate that activation of NF-κB signaling correlates with PCa progression; however, the precise underlying mechanism is not fully understood. Our studies show that activation of NF-κB signaling via deletion of one allele of its inhibitor, IκBα, did not induce prostatic tumorigenesis in our mouse model. However, activation of NF-κB signaling did increase the rate of tumor progression in the Hi-Myc mouse PCa model when compared to Hi-Myc alone. Using the non-malignant NF-κB activated androgen depleted mouse prostate, a NF-κB Activated Recurrence Predictor 21 (NARP21) gene signature was generated. The NARP21 signature successfully predicted disease-specific survival and distant metastases-free survival in patients with PCa. This transgenic mouse model derived gene signature provides a useful and unique molecular profile for human PCa prognosis, which could be used on a prostatic biopsy to predict indolent versus aggressive behavior of the cancer after surgery. PMID:24686169

NF-κB deregulation in splenic marginal zone lymphoma.

PubMed

Spina, Valeria; Rossi, Davide

2016-08-01

Splenic marginal zone lymphoma is a rare mature B-cell malignancy involving the spleen, bone marrow and blood. Over the past years, the rapid expansion of sequencing technologies allowing the genome-wide assessment of genomic, epigenetic and transcriptional changes has revolutionized our understanding of the biological basis of splenic marginal zone lymphoma by providing a comprehensive and unbiased view of the genes/pathways that are deregulated in this disease. NF-κB is a family of transcription factors that plays critical roles in development, survival, and activation of B lymphocytes. Consistent with the physiological involvement of NF-κB signalling in proliferation and commitment of mature B-cells to the marginal zone of the spleen, many oncogenic mutations involved in constitutive activation of the NF-κB pathway were recently identified in splenic marginal zone lymphoma. This review describes the progress in understanding the mechanism of NF-κB activation in splenic marginal zone lymphoma, including molecular, epigenetic and post-transcriptional modifications of NF-κB genes and of upstream pathways, and discusses how information gained from these efforts has provided new insights on potential targets of diagnostic, prognostic and therapeutic relevance for splenic marginal zone lymphoma. Copyright © 2016. Published by Elsevier Ltd.

NF1 mutations are recurrent in adult acute myeloid leukemia and confer poor outcome.

PubMed

Eisfeld, Ann-Kathrin; Kohlschmidt, Jessica; Mrózek, Krzysztof; Mims, Alice; Walker, Christopher J; Blachly, James S; Nicolet, Deedra; Orwick, Shelley; Maharry, Sophia E; Carroll, Andrew J; Powell, Bayard L; Kolitz, Jonathan E; Wang, Eunice S; Stone, Richard M; de la Chapelle, Albert; Byrd, John C; Bloomfield, Clara D

2018-06-05

Targeted mutation assessment of 81 genes in 1021 adults with de novo acute myeloid leukemia (AML) identified recurrent mutations in the neurofibromin 1 (NF1) gene in 52 (5.1%) patients, including 36 (5.2%) younger and 16 (4.8%) older patients, which suggests NF1 belongs to the 20 most frequently mutated genes in adult AML. NF1 mutations were found throughout the gene, and comprised missense, frameshift, and nonsense mutations. One mutation hotspot, at amino acid threonine 676 (Thr676), was found in 27% of AML patients with NF1 mutations. NF1-mutated patients belonged more often to the adverse European LeukemiaNet (ELN) risk category than NF1 wild-type patients. Among patients aged <60 years, the presence of NF1 Thr676 mutations was associated with lower complete remission (CR) rates (P = 0.04) and shorter overall survival (OS; P = 0.01), as was the presence of any NF1 mutation in patients in the adverse ELN risk category (CR, P = 0.05; OS, P < 0.001). CR rates were also lower in NF1-mutated patients aged ≥60 years compared with NF1 wild-type patients (P = 0.001). In summary, our findings provide novel insights into the frequency of NF1 mutations in AML, and are suggestive of an adverse prognostic impact in patients treated with standard chemotherapy.

Antiinflammatory effects of glucocorticoids in brain cells, independent of NF-kappa B.

PubMed

Bourke, E; Moynagh, P N

1999-08-15

Glucocorticoids are potent antiinflammatory drugs. They inhibit the expression of proinflammatory cytokines and adhesion molecules. It has recently been proposed that the underlying basis to such inhibition is the induction of the protein I kappa B, which inhibits the transcription factor NF-kappa B. The latter is a key activator of the genes encoding cytokines and adhesion molecules. The present study shows that the synthetic glucocorticoid, dexamethasone, inhibits the induction of the proinflammatory cytokine IL-8 and the adhesion molecules VCAM-1 and ICAM-1 in human 1321N1 astrocytoma and SK.N.SH neuroblastoma cells. However, dexamethasone failed to induce I kappa B or inhibit activation of NF-kappa B by IL-1 in the two cell types. EMSA confirmed the identity of the activated NF-kappa B by demonstrating that an oligonucleotide, containing the wild-type NF-kappa B-binding motif, inhibited formation of the NF-kappa B-DNA complexes whereas a mutated form of the NF-kappa B-binding motif was ineffective. In addition, supershift analysis showed that the protein subunits p50 and p65 were prevalent components in the activated NF-kappa B complexes. The lack of effect of dexamethasone on the capacity of IL-1 to activate NF-kappa B correlated with its inability to induce I kappa B and the ability of IL-1 to cause degradation of I kappa B, even in the presence of dexamethasone. The results presented in this paper strongly suggest that glucocorticoids may exert antiinflammatory effects in cells of neural origin by a mechanism(s) independent of NF-kappa B.

46 CFR 160.002-7 - Procedure for approval.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 6 2010-10-01 2010-10-01 false Procedure for approval. 160.002-7 Section 160.002-7 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Life Preservers, Kapok, Adult and Child (Jacket Type), Models 3...

Neurofibromatosis type 1 (NF1) gene: Beyond café au lait spots and dermal neurofibromas.

PubMed

Peltonen, Sirkku; Kallionpää, Roope A; Peltonen, Juha

2017-07-01

Neurofibromatosis 1 (NF1) occurs in 1:2000 births. The main diagnostic signs are visible on the skin, and this opens several interesting aspects for dermatological point of view. The NF1 syndrome is caused by mutations in the NF1 gene which encodes the tumor suppressor protein neurofibromin. Neurofibromin functions as a Ras-GTPase-activating protein (RasGAP), and NF1 mutations lead to overactivation of the Ras signalling pathway. The NF1 gene and neurofibromin have intriguing functions in keratinocytes and melanocytes. Neurofibromin regulates melanin synthesis and keratinocyte differentiation in a currently unknown manner. The NF1 gene has also an important but poorly understood role in tumorigenesis and cancer. Compared to the general population, NF1 patients have a fivefold risk for cancer and a more than 2000-fold risk for neurogenic malignancies. Mutations of the NF1 gene are common in numerous cancer types in patients without NF1, and this suggests a more general role for the NF1 gene in oncogenesis. In melanoma, NF1 mutations seem to drive tumorigenesis and contribute to drug resistance. In this article, we review the literature on neurofibromin with special attention to keratinocytes, melanocytes, NF1-related tumors and melanoma. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

48 CFR 39.002 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY 39.002 Definitions. As used in this part— Modular contracting means use of one or more contracts to acquire information technology systems in successive... technology, means that the information technology accurately processes date/time data (including, but not...

Late-phase synthesis of IκBα insulates the TLR4-activated canonical NF-κB pathway from noncanonical NF-κB signaling in macrophages

PubMed Central

Mukherjee, Tapas; Taye, Nandaraj; Vijayaragavan, Bharath; Chattopadhyay, Samit; Gomes, James; Basak, Soumen

2017-01-01

The nuclear factor κB (NF-κB) transcription factors coordinate the inflammatory immune response during microbial infection. Pathogenic substances engage canonical NF-κB signaling through the heterodimer RelA:p50, which is subjected to rapid negative feedback by inhibitor of κBα (IκBα). The noncanonical NF-κB pathway is required for the differentiation of immune cells; however, crosstalk between both pathways can occur. Concomitantly activated noncanonical signaling generates p52 from the p100 precursor. The synthesis of p100 is induced by canonical signaling, leading to formation of the late-acting RelA:p52 heterodimer. This crosstalk prolongs inflammatory RelA activity in epithelial cells to ensure pathogen clearance. We found that the Toll-like receptor 4 (TLR4)–activated canonical NF-κB signaling pathway is insulated from lymphotoxin β receptor (LTβR)–induced noncanonical signaling in mouse macrophage cell lines. Combined computational and biochemical studies indicated that the extent of NF-κB–responsive expression of Nfkbia, which encodes IκBα, inversely correlated with crosstalk. The Nfkbia promoter showed enhanced responsiveness to NF-κB activation in macrophages compared to that in fibroblasts. We found that this hyperresponsive promoter engaged the RelA:p52 dimer generated during costimulation of macrophages through TLR4 and LTβR to trigger synthesis of IκBα at late time points, which prevented the late-acting RelA crosstalk response. Together, these data suggest that despite the presence of identical signaling networks in cells of diverse lineages, emergent crosstalk between signaling pathways is subject to cell type–specific regulation. We propose that the insulation of canonical and noncanonical NF-κB pathways limits the deleterious effects of macrophage-mediated inflammation. PMID:27923915

Regionalized equations for bankfull-discharge and channel characteristics of streams in New York State—Hydrologic Region 6 in the Southern Tier of New York

USGS Publications Warehouse

Mulvihill, Christiane I.; Ernst, Anne G.; Baldigo, Barry P.

2005-01-01

Equations that relate bankfull discharge and channel characteristics (width, depth, and cross-sectional area) to drainage-area size at gaged sites are needed to define bankfull discharge and channel dimensions at ungaged sites and to provide information for watershed assessments, stream-channel classification, and the design of stream-restoration projects. Such equations are most accurate if derived from streams within an area of uniform hydrologic, climatic, and physiographic conditions and applied only within that region. In New York State, eight hydrologic regions were previously defined on the basis of similar high-flow (flood) characteristics. This report presents drainage areas and associated bankfull characteristics (discharge and channel dimensions) for surveyed streams in southwestern New York (Region 6).Stream-survey data and discharge records from 11 active (currently gaged) sites and 3 inactive (discontinued) sites were used in regression analyses to relate bankfull discharge and bankfull channel width, depth, and cross-sectional area to the size of the drainage area. The resulting equations are:(1) bankfull discharge, in cubic feet per second = 48.0*(drainage area, in square miles)0.842;(2) bankfull channel width, in feet = 16.9*(drainage area, in square miles)0.419;(3) bankfull channel depth, in feet = 1.04*(drainage area, in square miles)0.244; and(4) bankfull channel cross-sectional area, in square feet = 17.6*(drainage area, in square miles)0.662.The coefficient of determination (R2) for these four equations were 0.90, 0.79, 0.64, and 0.89, respectively. The high correlation coefficients for bankfull discharge and cross-sectional area indicate that much of the variation in these variables is explained by the size of the drainage area. The smaller correlation coefficients for bankfull channel width and depth indicate that other factors also affect these relations. Recurrence intervals for the estimated bankfull discharge of each stream ranged from 1

A role for NF-κB–dependent gene transactivation in sunburn

PubMed Central

Abeyama, Kazuhiro; Eng, William; Jester, James V.; Vink, Arie A.; Edelbaum, Dale; Cockerell, Clay J.; Bergstresser, Paul R.; Takashima, Akira

2000-01-01

Exposure of skin to ultraviolet (UV) radiation is known to induce NF-κB activation, but the functional role for this pathway in UV-induced cutaneous inflammation remains uncertain. In this study, we examined whether experimentally induced sunburn reactions in mice could be prevented by blocking UV-induced, NF-κB–dependent gene transactivation with oligodeoxynucleotides (ODNs) containing the NF-κB cis element (NF-κB decoy ODNs). UV-induced secretion of IL-1, IL-6, TNF-α, and VEGF by skin-derived cell lines was inhibited by the decoy ODNs, but not by the scrambled control ODNs. Systemic or local injection of NF-κB decoy ODNs also inhibited cutaneous swelling responses to UV irradiation. Moreover, local UV-induced inflammatory changes (swelling, leukocyte infiltration, epidermal hyperplasia, and accumulation of proinflammatory cytokines) were all inhibited specifically by topically applied decoy ODNs. Importantly, these ODNs had no effect on alternative types of cutaneous inflammation caused by irritant or allergic chemicals. These results indicate that sunburn reactions culminate from inflammatory events that are triggered by UV-activated transcription of NF-κB target genes, rather than from nonspecific changes associated with tissue damage. PMID:10862790

46 CFR 161.002-1 - Incorporation by reference.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Amendments to SOLAS 74), 1992—161.002-4(b). National Fire Protection Association (NFPA) National Fire Protection Association, 1 Batterymarch Park, Quincy, MA 02269. NFPA 72, National Fire Alarm Code, 1993—161...: SPECIFICATIONS AND APPROVAL ELECTRICAL EQUIPMENT Fire-Protective Systems § 161.002-1 Incorporation by reference...

46 CFR 161.002-1 - Incorporation by reference.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Amendments to SOLAS 74), 1992—161.002-4(b). National Fire Protection Association (NFPA) National Fire Protection Association, 1 Batterymarch Park, Quincy, MA 02269. NFPA 72, National Fire Alarm Code, 1993—161...: SPECIFICATIONS AND APPROVAL ELECTRICAL EQUIPMENT Fire-Protective Systems § 161.002-1 Incorporation by reference...

Gold nanoparticles induce transcriptional activity of NF-κB in a B-lymphocyte cell line

NASA Astrophysics Data System (ADS)

Sharma, Monita; Salisbury, Richard L.; Maurer, Elizabeth I.; Hussain, Saber M.; Sulentic, Courtney E. W.

2013-04-01

Gold nanoparticles (Au-NPs) have been designated as superior tools for biological applications owing to their characteristic surface plasmon absorption/scattering and amperometric (electron transfer) properties, in conjunction with low or no immediate toxicity towards biological systems. Many studies have shown the ease of designing application-based tools using Au-NPs but the interaction of this nanosized material with biomolecules in a physiological environment is an area requiring deeper investigation. Immune cells such as lymphocytes circulate through the blood and lymph and therefore are likely cellular components to come in contact with Au-NPs. The main aim of this study was to mechanistically determine the functional impact of Au-NPs on B-lymphocytes. Using a murine B-lymphocyte cell line (CH12.LX), treatment with citrate-stabilized 10 nm Au-NPs induced activation of an NF-κB-regulated luciferase reporter, which correlated with altered B lymphocyte function (i.e. increased antibody expression). TEM imaging demonstrated that Au-NPs can pass through the cellular membrane and therefore could interact with intracellular components of the NF-κB signaling pathway. Based on the inherent property of Au-NPs to bind to -thiol groups and the presence of cysteine residues on the NF-κB signal transduction proteins IκB kinases (IKK), proteins specifically bound to Au-NPs were extracted from CH12.LX cellular lysate exposed to 10 nm Au-NPs. Electrophoresis identified several bands, of which IKKα and IKKβ were immunoreactive. Further evaluation revealed activation of the canonical NF-κB signaling pathway as evidenced by IκBα phosphorylation at serine residues 32 and 36 followed by IκBα degradation and increased nuclear RelA. Additionally, expression of an IκBα super-repressor (resistant to proteasomal degradation) reversed Au-NP-induced NF-κB activation. Altered NF-κB signaling and cellular function in B-lymphocytes suggests a potential for off-target effects

NF-κB inhibition delays DNA damage–induced senescence and aging in mice

PubMed Central

Tilstra, Jeremy S.; Robinson, Andria R.; Wang, Jin; Gregg, Siobhán Q.; Clauson, Cheryl L.; Reay, Daniel P.; Nasto, Luigi A.; St Croix, Claudette M.; Usas, Arvydas; Vo, Nam; Huard, Johnny; Clemens, Paula R.; Stolz, Donna B.; Guttridge, Denis C.; Watkins, Simon C.; Garinis, George A.; Wang, Yinsheng; Niedernhofer, Laura J.; Robbins, Paul D.

2012-01-01

The accumulation of cellular damage, including DNA damage, is thought to contribute to aging-related degenerative changes, but how damage drives aging is unknown. XFE progeroid syndrome is a disease of accelerated aging caused by a defect in DNA repair. NF-κB, a transcription factor activated by cellular damage and stress, has increased activity with aging and aging-related chronic diseases. To determine whether NF-κB drives aging in response to the accumulation of spontaneous, endogenous DNA damage, we measured the activation of NF-κB in WT and progeroid model mice. As both WT and progeroid mice aged, NF-κB was activated stochastically in a variety of cell types. Genetic depletion of one allele of the p65 subunit of NF-κB or treatment with a pharmacological inhibitor of the NF-κB–activating kinase, IKK, delayed the age-related symptoms and pathologies of progeroid mice. Additionally, inhibition of NF-κB reduced oxidative DNA damage and stress and delayed cellular senescence. These results indicate that the mechanism by which DNA damage drives aging is due in part to NF-κB activation. IKK/NF-κB inhibitors are sufficient to attenuate this damage and could provide clinical benefit for degenerative changes associated with accelerated aging disorders and normal aging. PMID:22706308

TRIM45 negatively regulates NF-{kappa}B-mediated transcription and suppresses cell proliferation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shibata, Mio; Sato, Tomonobu; Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638

2012-06-22

Highlights: Black-Right-Pointing-Pointer NF-{kappa}B plays an important role in cell survival and carcinogenesis. Black-Right-Pointing-Pointer TRIM45 negatively regulates TNF{alpha}-induced NF-{kappa}B-mediated transcription. Black-Right-Pointing-Pointer TRIM45 overexpression suppresses cell growth. Black-Right-Pointing-Pointer TRIM45 acts as a repressor for the NF-{kappa}B signal and regulates cell growth. -- Abstract: The NF-{kappa}B signaling pathway plays an important role in cell survival, immunity, inflammation, carcinogenesis, and organogenesis. Activation of NF-{kappa}B is regulated by several posttranslational modifications including phosphorylation, neddylation and ubiquitination. The NF-{kappa}B signaling pathway is activated by two distinct signaling mechanisms and is strictly modulated by the ubiquitin-proteasome system. It has been reported that overexpression of TRIM45, one ofmore » the TRIM family ubiquitin ligases, suppresses transcriptional activities of Elk-1 and AP-1, which are targets of the MAPK signaling pathway. In this study, we showed that TRIM45 also negatively regulates TNF{alpha}-induced NF-{kappa}B-mediated transcription by a luciferase reporter assay and that TRIM45 lacking a RING domain also has an activity to inhibit the NF-{kappa}B signal. Moreover, we found that TRIM45 overexpression suppresses cell growth. These findings suggest that TRIM45 acts as a repressor for the NF-{kappa}B signal and regulates cell growth.« less

48 CFR 2811.002 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... whenever metric is the accepted industry system. Whenever possible, commercially developed metric... include requirements documents stated in soft metric, hybrid, or dual systems, except when impractical or... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Policy. 2811.002 Section...

48 CFR 2811.002 - Policy.

Code of Federal Regulations, 2012 CFR

2012-10-01

... whenever metric is the accepted industry system. Whenever possible, commercially developed metric... include requirements documents stated in soft metric, hybrid, or dual systems, except when impractical or... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Policy. 2811.002 Section...

48 CFR 2811.002 - Policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... whenever metric is the accepted industry system. Whenever possible, commercially developed metric... include requirements documents stated in soft metric, hybrid, or dual systems, except when impractical or... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Policy. 2811.002 Section...

48 CFR 2811.002 - Policy.

Code of Federal Regulations, 2014 CFR

2014-10-01

... whenever metric is the accepted industry system. Whenever possible, commercially developed metric... include requirements documents stated in soft metric, hybrid, or dual systems, except when impractical or... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Policy. 2811.002 Section...

48 CFR 2811.002 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... whenever metric is the accepted industry system. Whenever possible, commercially developed metric... include requirements documents stated in soft metric, hybrid, or dual systems, except when impractical or... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Policy. 2811.002 Section...

48 CFR 39.002 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY 39.002 Definitions. As used in this part— Modular contracting means use of one or more contracts to acquire information technology systems in successive...; or (5) Is critical to the direct fulfillment of military or intelligence missions. This does not...

48 CFR 39.002 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY 39.002 Definitions. As used in this part— Modular contracting means use of one or more contracts to acquire information technology systems in successive...; or (5) Is critical to the direct fulfillment of military or intelligence missions. This does not...

48 CFR 39.002 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY 39.002 Definitions. As used in this part— Modular contracting means use of one or more contracts to acquire information technology systems in successive...; or (5) Is critical to the direct fulfillment of military or intelligence missions. This does not...

48 CFR 39.002 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY 39.002 Definitions. As used in this part— Modular contracting means use of one or more contracts to acquire information technology systems in successive...; or (5) Is critical to the direct fulfillment of military or intelligence missions. This does not...

NF-κB controls four genes encoding core enzymes of tricarboxylic acid cycle.

PubMed

Zhou, Fei; Xu, Xinhui; Wu, Jian; Wang, Danyang; Wang, Jinke

2017-07-20

NF-κB may promote tumor progression by altering cell metabolism. Hence, finding its target genes that are involved in cell metabolism is helpful for understanding its role in tumor growth. Here we discovered four metabolism-related target genes of this transcription factor. By analyzing a chromatin immunoprecipitation followed by deep sequencing (ChIP-Seq) data that characterizing the global binding sites (BSs) of NF-κB RelA in the TNFα-stimulated HeLa cells, we found that four genes that encode core enzymes of the tricarboxylic acid (TCA) cycle, including IDH1, IDH3A, ACO2, and SUCLA2, were multiply bound by this transcription factor. The subsequent bioinformatic analysis revealed that the NF-κB BSs contained many canonical κB sequences and the NF-κB-like DNA-binding motifs. Detection of ChIPed DNA with polymerase chain reaction (ChIP-PCR) also indicated that the NF-κB BSs were bound by NF-κB in both TNFα-treated HeLa and HepG2 cells. The reporter construct showed that the NF-κB BSs could activate the luciferase expression in cells in a NF-κB-specific manner. The quantitative PCR and Western blot detections demonstrated that NF-κB could regulate the expressions of IDH1, IDH3A, and ACO2 genes at both mRNA and protein levels and that of SUCLA2 gene at mRNA level in the TNFα-treated HeLa and HepG2 cells. Based on these investigations we identified the four genes as new target genes of NF-κB. The finding provides new insights into the role of NF-κB in cellular energetic metabolism, which may be beneficial for understanding the metabolic physiology of tumor growth. Copyright © 2017. Published by Elsevier B.V.

Use of pharmacy data to evaluate smoking regulations' impact on sales of nicotine replacement therapies in New York City.

PubMed

Metzger, Kristina B; Mostashari, Farzad; Kerker, Bonnie D

2005-06-01

Recently, New York City and New York State increased cigarette excise taxes and New York City implemented a smoke-free workplace law. To assess the impact of these policies on smoking cessation in New York City, we examined over-the-counter sales of nicotine replacement therapy (NRT) products. Pharmacy sales data were collected in real time as part of nontraditional surveillance activities. We used Poisson generalized estimating equations to analyze the effect of smoking-related policies on pharmacy-specific weekly sales of nicotine patches and gum. We assessed effect modification by pharmacy location. We observed increases in NRT product sales during the weeks of the cigarette tax increases and the smoke-free workplace law. Pharmacies in low-income areas generally had larger and more persistent increases in response to tax increases than those in higher-income areas. Real-time monitoring of existing nontraditional surveillance data, such as pharmacy sales of NRT products, can help assess the effects of public policies on cessation attempts. Cigarette tax increases and smoke-free workplace regulations were associated with increased smoking cessation attempts in New York City, particularly in low-income areas.

Caring for Immigrants: Health Care Safety Nets in Los Angeles, New York, Miami, and Houston.

ERIC Educational Resources Information Center

Ku, Leighton; Freilich, Alyse

This report assesses how the loss of Medicaid coverage following welfare reform has influenced changes in health care systems for immigrants in four urban areas: Los Angeles, California; New York, New York; Houston, Texas; and Miami, Florida. Survey data indicate that over half of low-income immigrants were uninsured in 1998, a level roughly…

Status Report on the Impact on New York City of President Reagan's Proposed Budget Cuts.

ERIC Educational Resources Information Center

Community Service Society of New York, NY.

This report describes the effects that President Reaqan's proposed budget cuts will have on New York City. The report lists each affected program, the proposed cuts, Senate action, the House Budget Committee recommendation, and the impact on New York City. Areas covered by the program cuts reviewed include: (1) employment; (2) income security; (3)…

Dissolved methane in New York groundwater, 1999-2011

USGS Publications Warehouse

Kappel, William M.; Nystrom, Elizabeth A.

2012-01-01

New York State is underlain by numerous bedrock formations of Cambrian to Devonian age that produce natural gas and to a lesser extent oil. The first commercial gas well in the United States was dug in the early 1820s in Fredonia, south of Buffalo, New York, and produced methane from Devonian-age black shale. Methane naturally discharges to the land surface at some locations in New York. At Chestnut Ridge County Park in Erie County, just south of Buffalo, N.Y., several surface seeps of natural gas occur from Devonian black shale, including one behind a waterfall. Methane occurs locally in the groundwater of New York; as a result, it may be present in drinking-water wells, in the water produced from those wells, and in the associated water-supply systems (Eltschlager and others, 2001). The natural gas in low-permeability bedrock formations has not been accessible by traditional extraction techniques, which have been used to tap more permeable sandstone and carbonate bedrock reservoirs. However, newly developed techniques involving horizontal drilling and high-volume hydraulic fracturing have made it possible to extract previously inaccessible natural gas from low-permeability bedrock such as the Marcellus and Utica Shales. The use of hydraulic fracturing to release natural gas from these shale formations has raised concerns with water-well owners and water-resource managers across the Marcellus and Utica Shale region (West Virginia, Pennsylvania, New York and parts of several other adjoining States). Molofsky and others (2011) documented the widespread natural occurrence of methane in drinking-water wells in Susquehanna County, Pennsylvania. In the same county, Osborn and others (2011) identified elevated methane concentrations in selected drinking-water wells in the vicinity of Marcellus gas-development activities, although pre-development samples were not available for comparison. In order to manage water resources in areas of gas-well drilling and hydraulic

NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice.

PubMed

Burkitt, Michael D; Hanedi, Abdalla F; Duckworth, Carrie A; Williams, Jonathan M; Tang, Joseph M; O'Reilly, Lorraine A; Putoczki, Tracy L; Gerondakis, Steve; Dimaline, Rod; Caamano, Jorge H; Pritchard, D Mark

2015-07-01

NF-κB signalling is an important factor in the development of inflammation-associated cancers. Mouse models of Helicobacter-induced gastric cancer and colitis-associated colorectal cancer have demonstrated that classical NF-κB signalling is an important regulator of these processes. In the stomach, it has also been demonstrated that signalling involving specific NF-κB proteins, including NF-κB1/p50, NF-κB2/p52, and c-Rel, differentially regulate the development of gastric pre-neoplasia. To investigate the effect of NF-κB subunit loss on colitis-associated carcinogenesis, we administered azoxymethane followed by pulsed dextran sodium sulphate to C57BL/6, Nfkb1(-/-), Nfkb2(-/-), and c-Rel(-/-) mice. Animals lacking the c-Rel subunit were more susceptible to colitis-associated cancer than wild-type mice, developing 3.5 times more colonic polyps per animal than wild-type mice. Nfkb2(-/-) mice were resistant to colitis-associated cancer, developing fewer polyps per colon than wild-type mice (median 1 compared to 4). To investigate the mechanisms underlying these trends, azoxymethane and dextran sodium sulphate were administered separately to mice of each genotype. Nfkb2(-/-) mice developed fewer clinical signs of colitis and exhibited less severe colitis and an attenuated cytokine response compared with all other groups following DSS administration. Azoxymethane administration did not fully suppress colonic epithelial mitosis in c-Rel(-/-) mice and less colonic epithelial apoptosis was also observed in this genotype compared to wild-type counterparts. These observations demonstrate different functions of specific NF-κB subunits in this model of colitis-associated carcinogenesis. NF-κB2/p52 is necessary for the development of colitis, whilst c-Rel-mediated signalling regulates colonic epithelial cell turnover following DNA damage. © 2015 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain

View of southeastern New York State

NASA Image and Video Library

1973-08-15

SL3-87-299 (July-September 1973) --- A vertical view of southeastern New York State is seen in this Skylab 3 Earth Resources Experiments Package S190-B (five-inch Earth terrain camera) infrared photograph taken from the Skylab space station in Earth orbit. An 18-inch, 450mm lens and type 2443 infrared Ektachrome film was used. This picture covers the northern part of New Jersey, a part of northwestern Pennsylvania, and the western tip of Connecticut. The body of water is Long Island Sound. The wide Hudson River flows southward across a corner of the photograph. The New York City metropolitan area occupies part of the picture. Federal agencies participating with NASA on the EREP project are the Departments of Agriculture, Commerce, Interior, the Environmental Protection Agency and the Corps of Engineers. All EREP photography is available to the public through the Department of Interior?s Earth Resources Observations Systems Data Center, Sioux Falls, South Dakota, 57198. Photo credit: NASA

Increased expression of NF-AT3 and NF-AT4 in the atria correlates with procollagen I carboxyl terminal peptide and TGF-β1 levels in serum of patients with atrial fibrillation.

PubMed

Zhao, Fei; Zhang, ShiJiang; Chen, YiJiang; Gu, WeiDong; Ni, BuQing; Shao, YongFeng; Wu, YanHu; Qin, JianWei

2014-11-25

Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice. Unfortunately, the precise mechanisms and sensitive serum biomarkers of atrial remodeling in AF remain unclear. The aim of this study was to determine whether the expression of the transcription factors NF-AT3 and NF-AT4 correlate with atrial structural remodeling of atrial fibrillation and serum markers for collagen I and III synthesis. Right and left atrial specimens were obtained from 90 patients undergoing valve replacement surgery. The patients were divided into sinus rhythm (n = 30), paroxysmal atrial fibrillation (n = 30), and persistent atrial fibrillation (n = 30) groups. NF-AT3, NF-AT4, and collagen I and III mRNA and protein expression in atria were measured. We also tested the levels of the carboxyl-terminal peptide from pro-collagen I, the N-terminal type I procollagen propeptides, the N-terminal type III procollagen propeptides, and TGF-β1 in serum using an enzyme immunosorbent assay. NF-AT3 and NF-AT4 mRNA and protein expression were increased in the AF groups, especially in the left atrium. NF-AT3 and NF-AT4 expression in the right atrium was increased in the persistent atrial fibrillation group compared the sinus rhythm group with similar valvular disease. In patients with AF, the expression levels of nuclear NF-AT3 and NF-AT4 correlated with those of collagens I and III in the atria and with PICP and TGF-β1 in blood. These data support the hypothesis that nuclear NF-AT3 and NF-AT4 participates in atrial structural remodeling, and that PICP and TGF-β1 levels may be sensitive serum biomarkers to estimate atrial structural remodeling with atrial fibrillation.

48 CFR 711.002-70 - Metric system waivers.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Metric system waivers. 711... ACQUISITION PLANNING DESCRIBING AGENCY NEEDS 711.002-70 Metric system waivers. (a) Criteria. The FAR 11.002(b) requirement to use the metric system of measurement for specifications and quantitative data that are...

48 CFR 711.002-70 - Metric system waivers.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Metric system waivers. 711... ACQUISITION PLANNING DESCRIBING AGENCY NEEDS 711.002-70 Metric system waivers. (a) Criteria. The FAR 11.002(b) requirement to use the metric system of measurement for specifications and quantitative data that are...

48 CFR 711.002-70 - Metric system waivers.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Metric system waivers. 711... ACQUISITION PLANNING DESCRIBING AGENCY NEEDS 711.002-70 Metric system waivers. (a) Criteria. The FAR 11.002(b) requirement to use the metric system of measurement for specifications and quantitative data that are...

48 CFR 711.002-70 - Metric system waivers.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Metric system waivers. 711... ACQUISITION PLANNING DESCRIBING AGENCY NEEDS 711.002-70 Metric system waivers. (a) Criteria. The FAR 11.002(b) requirement to use the metric system of measurement for specifications and quantitative data that are...

Groundwater Quality in Central New York, 2007

USGS Publications Warehouse

Eckhardt, David A.V.; Reddy, J.E.; Shaw, Stephen B.

2009-01-01

Water samples were collected from 7 production wells and 28 private residential wells in central New York from August through December 2007 and analyzed to characterize the chemical quality of groundwater. Seventeen wells are screened in sand and gravel aquifers, and 18 are finished in bedrock aquifers. The wells were selected to represent areas of greatest groundwater use and to provide a geographical sampling from the 5,799-square-mile study area. Samples were analyzed for 6 physical properties and 216 constituents, including nutrients, major inorganic ions, trace elements, radionuclides, pesticides, volatile organic compounds, phenolic compounds, organic carbon, and 4 types of bacteria. Results indicate that groundwater used for drinking supply is generally of acceptable quality, although concentrations of some constituents or bacteria exceeded at least one drinking-water standard at several wells. The cations detected in the highest concentrations were calcium, magnesium, and sodium; anions detected in the highest concentrations were bicarbonate, chloride, and sulfate. The predominant nutrients were nitrate and ammonia, but no nutrients exceeded Maximum Contaminant Levels (MCLs). The trace elements barium, boron, lithium, and strontium were detected in every sample; the trace elements present in the highest concentrations were barium, boron, iron, lithium, manganese, and strontium. Fifteen pesticides, including seven pesticide degradates, were detected in water from 17 of the 35 wells, but none of the concentrations exceeded State or Federal MCLs. Sixteen volatile organic compounds were detected in water from 15 of the 35 wells. Nine analytes and three types of bacteria were detected in concentrations that exceeded Federal and State drinking-water standards, which typically are identical. One sample had a water color that exceeded the U.S. Environmental Protection Agency (USEPA) Secondary Maximum Contaminant Level (SMCL) and the New York State MCL of 10 color

Instanton dominance over $$a_s$$ at low momenta from lattice QCD simulations at $$N_f=0$$, $$N_f=2+1$$ and $$N_f=2+1+1$$

DOE Office of Scientific and Technical Information (OSTI.GOV)

Athenodorou, Andreas; Boucaud, Philippe; de Soto, Feliciano

We report on an instanton-based analysis of the gluon Green functions in the Landau gauge for low momenta; in particular we use lattice results for αs in the symmetric momentum subtraction scheme (MOM) for large-volume lattice simulations. We have exploited quenched gauge field configurations, Nf = 0, with both Wilson and tree-level Symanzik improved actions, and unquenched ones with Nf = 2 + 1 and Nf = 2 + 1 + 1 dynamical flavors (domain wall and twisted-mass fermions, respectively).We show that the dominance of instanton correlations on the low-momenta gluon Green functions can be applied to the determination ofmore » phenomenological parameters of the instanton liquid and, eventually, to a determination of the lattice spacing.We furthermore apply the Gradient Flow to remove short-distance fluctuations. The Gradient Flow gets rid of the QCD scale, ΛQCD, and reveals that the instanton prediction extents to large momenta. For those gauge field configurations free of quantum fluctuations, the direct study of topological charge density shows the appearance of large-scale lumps that can be identified as instantons, giving access to a direct study of the instanton density and size distribution that is compatible with those extracted from the analysis of the Green functions.« less

Mas aya del ancho rio: Mexicanos in Western New York

ERIC Educational Resources Information Center

Rivera, George, Jr.; Mejia, Juventino

1976-01-01

Examining Chicanos who live in western New York, the study distinguished between native types of Chicano residents and compared these along several areas of concern: demographic variables, intermarriage and the family, and self-identification and perceptions of discrimination. (NQ)

Estimating total forest biomass in New York, 1993

Treesearch

Eric Wharton; Carol Alerich; David A. Drake; David A. Drake

1997-01-01

Presents methods for synthesizing information from existing biomass literature for estimating biomass over extensive forest areas with specific applications to New York. Tables of appropriate regression equations and the tree and shrub species to which these equations can be applied are presented well as biomass estimates at the county, geographic unit, and state level...

46 CFR 161.002-1 - Incorporation by reference.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Amendments to SOLAS 74, and 1994 Amendments to SOLAS 74), 1992—161.002-4(b). National Fire Protection Association (NFPA) National Fire Protection Association, 1 Batterymarch Park, Quincy, MA 02269. NFPA 72, National Fire Alarm Code, 1993—161.002-4(b). Lloyd's Register of Shipping (LR) Lloyd's Register of Shipping...

46 CFR 161.002-1 - Incorporation by reference.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Amendments to SOLAS 74, and 1994 Amendments to SOLAS 74), 1992—161.002-4(b). National Fire Protection Association (NFPA) National Fire Protection Association, 1 Batterymarch Park, Quincy, MA 02269. NFPA 72, National Fire Alarm Code, 1993—161.002-4(b). Lloyd's Register of Shipping (LR) Lloyd's Register of Shipping...

FIRE extended time/limited area observations at Palisades, New York

NASA Technical Reports Server (NTRS)

Robinson, David A.; Kukla, George; Frei, Alan

1990-01-01

Downwelling shortwave and longwave irradiation are being continuously monitored at Palisades, New York as part of the First International Satellite Cloud Climatology Project (ISCCP) Regional Experiment (FIRE) Extended Time/Limited Area Initiative. In addition, fisheye (180 degree) sky photographs are taken at the times of NOAA 9 and LANDSAT satellite overpasses on select days, particularly when cirrus clouds are present. Measurements of incoming shortwave (0.28 to 2.80 microns) hemispheric and diffuse, hemispheric near infrared (0.7 to 2.80 microns), and downwelling hemispheric infrared (4.0 to 50.0 microns) irradiation have been made from a rooftop location on the grounds of the Lamont-Doherty Geological Observatory since December 1986. The three Eppley Precision Spectral Pyranometers and the Eppley Pyrgeometer used to measure these variables were calibrated with Colorado State University instruments at Madison, Wisconsin as part of the FIRE Intensive Laboratory. Pyrgeometer output contains an adjustment for body temperature but not for dome temperature. Data are transmitted to a Campbell CR-21 Digital Recorder, where one minute averages of ten second samples are stored and subsequently dumped to a cassette recorder. Using a Campbell C-20 Cassette Interface, these data are transferred to an Apple Macintosh computer for analysis and for archiving on floppy disks. In addition to the raw irradiances collected, variables derived from these data are generated and stored. These include: the ratio of near infrared irradiation to visible irradiation and the fraction of the full shortwave irradiation which is diffuse; and will soon include: shortwave transmissivity and optical depth in the shortwave. Sky photographs are taken with an Olympus OM2-N 35 mm camera and are timed to be coincident with overpassing NOAA and LANDSAT satellites. Palisades is within the field of view of the NOAA 9 daily in the middle to late afternoon. The satellite viewing angle is within 45 degrees

75 FR 36110 - Notice of Inventory Completion: New York University College of Dentistry, New York, NY

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-24

... University College of Dentistry, New York, NY AGENCY: National Park Service, Interior. ACTION: Notice. Notice... the New York University College of Dentistry, New York, NY. The human remains were removed from... College of Dentistry professional staff in consultation with representatives of the Alabama-Quassarte...

Locating provisioning ecosystem services in urban forests: Forageable woody species in New York City, USA

Treesearch

Patrick T. Hurley; Marla R. Emery

2017-01-01

Scholarship on the ecosystem services provided by urban forests has focused on regulating and supporting services, with a growing body of research examining provisioning and cultural ecosystem services from farms and gardens in metropolitan areas. Using the case of New York, New York, USA, we propose a method to assess the supply of potential provisioning ecosystem...

Hazardous Waste Cleanup: Buffalo Color Corporation in Buffalo, New York

EPA Pesticide Factsheets

Buffalo Color Corporation, located in an industrial area in Buffalo, New York, occupies approximately 42 acres adjacent to the Buffalo River, along Elk and Lee streets. The plant has produced dyestuffs and organic chemicals since 1879, when it was built by

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

PubMed Central

Luedde, Tom; Schwabe, Robert F.

2012-01-01

Hepatic cirrhosis and hepatocellular carcinoma (HCC) are the most common causes of death in patients with chronic liver disease. Chronic liver injury of virtually any etiology triggers inflammatory and wound healing responses that in the long run promote the development of hepatic fibrosis and HCC. Here, we review the role of the transcription factor nuclear factor-κB (NF-κB), a master regulator of inflammation and cell death, in the development of hepatocellular injury, liver fibrosis and HCC, with a particular focus on the role of NF-κB in different cellular compartments of the liver. We propose that NF-κB acts as a central link between hepatic injury, fibrosis and HCC, and that it may represent a target for the prevention or treatment of liver fibrosis and HCC. However, NF-κB acts as a two-edged sword and inhibition of NF-κB may not only exert beneficial effects but also negatively impact hepatocyte viability, especially when NF-κB inhibition is pronounced. Finding appropriate targets or identifying drugs that either exert only a moderate effect on NFκB activity or that can be specifically delivered to nonparenchymal cells will be essential to avoid the increase in liver injury associated with complete NF-κB blockade in hepatocytes. PMID:21293511

About Learning Disabilities and NF

MedlinePlus

... learning disabilities. For example, a diffi- culty in math may result from a weakness in any number ... the child with NF1 to acquire numeracy skills. Mathematics has its own language and this can cause ...

Ground Water Atlas of the United States: Segment 12, Connecticut, Maine, Massachusetts, New Hampshire, New York, Rhode Island, Vermont

USGS Publications Warehouse

Olcott, Perry G.

1995-01-01

The State of New York and the six New England States of Maine, Vermont, New Hampshire, Massachusetts, Connecticut, and Rhode Island compose Segment 12 of this Atlas (fig. 1). The seven States have a total land area of about 116,000 square miles (table 1); all but a small area in southwestern New York has been glaciated. Population in the States of Segment 12 totals about 30,408,000 (table 1) and is concentrated in southern and eastern Massachusetts, Connecticut, Rhode Island, and especially New York (fig. 1). The northern part of the segment and the mountainous areas of New York and much of New Hampshire, Vermont, and Maine are sparsely populated. The percentage of population supplied from ground-water sources during 1980 was 54 to 60 percent in Maine, New Hampshire, and Vermont (table 1). Nearly all rural, domestic, and small-community water systems obtain water from wells that are, in comparison with other sources, the safest and the least expensive to install and maintain. Where water demand is great-in the urban areas of New York, Connecticut, Massachusetts, and Rhode Island-sophisticated reservoir, pipeline, and purification systems are economically feasible and are needed to meet demands. Surface water is the principal source of supply in these four States, and ground water was used to supply only 24 to 35 percent of their population during 1980 (table 1).

Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway.

PubMed

Chen, Jingyu; Lobb, Ian T; Morin, Pierre; Novo, Sonia M; Simpson, James; Kennerknecht, Kathrin; von Kriegsheim, Alex; Batchelor, Emily E; Oakley, Fiona; Stark, Lesley A

2018-06-05

p53 as an effector of nucleolar stress is well defined, but p53 independent mechanisms are largely unknown. Like p53, the NF-κB transcription factor plays a critical role in maintaining cellular homeostasis under stress. Many stresses that stimulate NF-κB also disrupt nucleoli. However, the link between nucleolar function and activation of the NF-κB pathway is as yet unknown. Here we demonstrate that artificial disruption of the PolI complex stimulates NF-κB signalling. Unlike p53 nucleolar stress response, this effect does not appear to be linked to inhibition of rDNA transcription. We show that specific stress stimuli of NF-κB induce degradation of a critical component of the PolI complex, TIF-IA. This degradation precedes activation of NF-κB and is associated with increased nucleolar size. It is mimicked by CDK4 inhibition and is dependent upon a novel pathway involving UBF/p14ARF and S44 of the protein. We show that blocking TIF-IA degradation blocks stress effects on nucleolar size and NF-κB signalling. Finally, using ex vivo culture, we show a strong correlation between degradation of TIF-IA and activation of NF-κB in freshly resected, human colorectal tumours exposed to the chemopreventative agent, aspirin. Together, our study provides compelling evidence for a new, TIF-IA-NF-κB nucleolar stress response pathway that has in vivo relevance and therapeutic implications.

Functional Analysis of Human NF1 in Drosophila

DTIC Science & Technology

2009-01-01

syndrome (NS) affect LTM. Noonan syndrome is one of so-called Ras-related disorders as NF1 is. It shares symptoms with NF1 and is also resulted from...3. Noonan Syndrome Elevated MAPK activation is a consistent biochemical hallmark of Noonan syndrome (NS) as well as of other phenotypically...mutations associated with Noonan syndrome . Our studies also showed that wild-type CSW overexpression dramatically shortens the inter-trial interval

Pathogenetic Importance and Therapeutic Implications of NF-κB in Lymphoid Malignancies

PubMed Central

Lim, Kian-Huat; Yang, Yibin; Staudt, Louis M.

2014-01-01

Summary Derangement of the nuclear factor κB (NF-κB) pathway initiates and/or sustains many types of human cancer. B-cell malignancies are particularly affected by oncogenic mutations, translocations, and copy number alterations affecting key components the NF-κB pathway, most likely owing to the pervasive role of this pathway in normal B cells. These genetic aberrations cause tumors to be ‘addicted’ to NF-κB, which can be exploited therapeutically. Since each subtype of lymphoid cancer utilizes different mechanisms to activate NF-κB, several different therapeutic strategies are needed to address this pathogenetic heterogeneity. Fortunately, a number of drugs that block signaling cascades leading to NF-κB are in early phase clinical trials, several of which are already showing activity in lymphoid malignancies. PMID:22435566

48 CFR 10.002 - Procedures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... MARKET RESEARCH 10.002 Procedures. (a) Acquisitions begin with a description of the Government's needs stated in terms sufficient to allow conduct of market research. (b) Market research is then conducted to... could be modified to meet the Government's needs. (1) The extent of market research will vary, depending...

75 FR 52021 - Notice of Inventory Completion: New York University College of Dentistry, New York, NY

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-24

... University College of Dentistry, New York, NY AGENCY: National Park Service, Interior. ACTION: Notice. Notice... University College of Dentistry, New York, NY. The human remains were removed from an unknown location. This... the human remains was made by New York University College of Dentistry professional staff in...

75 FR 33329 - Notice of Inventory Completion: New York University College of Dentistry, New York, NY

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-11

... University College of Dentistry, New York, NY AGENCY: National Park Service, Interior. ACTION: Notice. Notice... and control of the New York University College of Dentistry, New York, NY. The human remains were... College of Dentistry professional staff in consultation with representatives of the Tuscarora Nation of...

75 FR 52021 - Notice of Inventory Completion: New York University College of Dentistry, New York, NY

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-24

... University College of Dentistry, New York, NY AGENCY: National Park Service, Interior. ACTION: Notice. Notice... University College of Dentistry, New York, NY. The human remains were removed from Port Clarence, Nome County... the human remains was made by New York University College of Dentistry professional staff in...

Erosion studies on the Schoharie Watershed, New York

Treesearch

Irvin C. Reigner

1951-01-01

When New York City suffered a serious water shortage in 1949-50, some of the reservoirs in its water-supply system were drained almost empty. In some places land that had been covered with water for nearly a hundred years was exposed. This provided an unique opportunity for studying sedimentation and erosion problems in this area.

Port and Waterways Safety Assessment Workshop Report, New York

DTIC Science & Technology

2008-09-01

conduct Operation Clear Channel (14) • Increase the number of small craft fueling stations outside the port area (2) • Expand VTS AOR to include the...Island (6) • Increase the number of fueling stations outside of the port area (5) • Encourage less aggressive timetables for commuter ferries (5...data available through Stevens Institute of Technology, sponsored by the State of New York • Ambrose Light being replaced with a NOAA weather

48 CFR 11.002 - Policy.

Code of Federal Regulations, 2012 CFR

2012-10-01

... seq.), designates the metric system of measurement as the preferred system of weights and measures for United States trade and commerce, and it requires that each agency use the metric system of measurement... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Policy. 11.002 Section 11...

48 CFR 11.002 - Policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... seq.), designates the metric system of measurement as the preferred system of weights and measures for United States trade and commerce, and it requires that each agency use the metric system of measurement... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Policy. 11.002 Section 11...

48 CFR 11.002 - Policy.

Code of Federal Regulations, 2014 CFR

2014-10-01

... seq.), designates the metric system of measurement as the preferred system of weights and measures for United States trade and commerce, and it requires that each agency use the metric system of measurement... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Policy. 11.002 Section 11...

NF-κB as a Therapeutic Target in Inflammatory-Associated Bone Diseases

PubMed Central

Lin, T.-h.; Pajarinen, J.; Lu, L.; Nabeshima, A.; Cordova, L.A.; Yao, Z.; Goodman, S.B.

2017-01-01

Inflammation is a defensive mechanism for pathogen clearance and maintaining tissue homeostasis. In the skeletal system, inflammation is closely associated with many bone disorders including fractures, nonunions, periprosthetic osteolysis (bone loss around orthopedic implants), and osteoporosis. Acute inflammation is a critical step for proper bone-healing and bone-remodeling processes. On the other hand, chronic inflammation with excessive proinflammatory cytokines disrupts the balance of skeletal homeostasis involving osteoblastic (bone formation) and osteoclastic (bone resorption) activities. NF-κB is a transcriptional factor that regulates the inflammatory response and bone-remodeling processes in both bone-forming and bone-resorption cells. In vitro and in vivo evidences suggest that NF-κB is an important potential therapeutic target for inflammation-associated bone disorders by modulating inflammation and bone-remodeling process simultaneously. The challenges of NF-κB-targeting therapy in bone disorders include: (1) the complexity of canonical and noncanonical NF-κB pathways; (2) the fundamental roles of NF-κB-mediated signaling for bone regeneration at earlier phases of tissue damage and acute inflammation; and (3) the potential toxic effects on nontargeted cells such as lymphocytes. Recent developments of novel inhibitors with differential approaches to modulate NF-κB activity, and the controlled release (local) or bone-targeting drug delivery (systemic) strategies, have largely increased the translational application of NF-κB therapy in bone disorders. Taken together, temporal modulation of NF-κB pathways with the combination of recent advanced bone-targeting drug delivery techniques is a highly translational strategy to reestablish homeostasis in the skeletal system. PMID:28215222

Constitutive overexpression of the TaNF-YB4 gene in transgenic wheat significantly improves grain yield

PubMed Central

Yadav, Dinesh; Shavrukov, Yuri; Bazanova, Natalia; Chirkova, Larissa; Borisjuk, Nikolai; Kovalchuk, Nataliya; Ismagul, Ainur; Parent, Boris; Langridge, Peter; Hrmova, Maria; Lopato, Sergiy

2015-01-01

Heterotrimeric nuclear factors Y (NF-Ys) are involved in regulation of various vital functions in all eukaryotic organisms. Although a number of NF-Y subunits have been characterized in model plants, only a few have been functionally evaluated in crops. In this work, a number of genes encoding NF-YB and NF-YC subunits were isolated from drought-tolerant wheat (Triticum aestivum L. cv. RAC875), and the impact of the overexpression of TaNF-YB4 in the Australian wheat cultivar Gladius was investigated. TaNF-YB4 was isolated as a result of two consecutive yeast two-hybrid (Y2H) screens, where ZmNF-YB2a was used as a starting bait. A new NF-YC subunit, designated TaNF-YC15, was isolated in the first Y2H screen and used as bait in a second screen, which identified two wheat NF-YB subunits, TaNF-YB2 and TaNF-YB4. Three-dimensional modelling of a TaNF-YB2/TaNF-YC15 dimer revealed structural determinants that may underlie interaction selectivity. The TaNF-YB4 gene was placed under the control of the strong constitutive polyubiquitin promoter from maize and introduced into wheat by biolistic bombardment. The growth and yield components of several independent transgenic lines with up-regulated levels of TaNF-YB4 were evaluated under well-watered conditions (T1–T3 generations) and under mild drought (T2 generation). Analysis of T2 plants was performed in large deep containers in conditions close to field trials. Under optimal watering conditions, transgenic wheat plants produced significantly more spikes but other yield components did not change. This resulted in a 20–30% increased grain yield compared with untransformed control plants. Under water-limited conditions transgenic lines maintained parity in yield performance. PMID:26220082

33 CFR 165.168 - Safety Zones; Coast Guard Captain of the Port New York Fireworks Displays.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Safety Zones; Coast Guard Captain... Guard District § 165.168 Safety Zones; Coast Guard Captain of the Port New York Fireworks Displays. (a) New York Harbor. The following areas are safety zones: (1) Liberty Island Safety Zone: All waters of...

Oleanane-triterpenoids from Panax stipuleanatus inhibit NF-κB

PubMed Central

Liang, Chun; Ding, Yan; Song, Seok Bean; Kim, Jeong Ah; Cuong, Nguyen Manh; Ma, Jin Yeul; Kim, Young Ho

2013-01-01

In continuation of our research to find biological components from Panax stipuleanatus, four oleanane-type triterpenes (12 to 15) were isolated successively. Fifteen oleanane-type saponins (1 to 15) were evaluated for nuclear factor (NF)-κB activity using a luciferase reporter gene assay in HepG2 cells. Compounds 6 to 11 inhibited NF-κB, with IC50 values between 3.1 to 18.9 μM. The effects on inducible nitric oxide synthase and cyclooxygenase-2 by compounds 8, 10, and 11 were also examined using reverse transcription-polymerase chain reaction. Three compounds (8, 10, and 11) inhibited NF-κB activity by reducing the concentration of inflammatory factors in HepG2 cells. PMID:23717159

Neuroimaging findings of extensive sphenoethmoidal dysplasia in NF1.

PubMed

Tam, Allison; Sliepka, Joseph M; Bellur, Sunil; Bray, Collin Douglas; Lincoln, Christie M; Nagamani, Sandesh C S

2018-05-16

Whereas isolated sphenoid wing dysplasia (SWD) is a well-known clinical feature in neurofibromatosis 1 (NF1), extensive cranial defects involving multiple bones have been rarely reported in this disorder. In this report, we describe the clinical course of a 20-year-old male with NF1 and an extensive cranial bone dysplasia. The large sphenoethmoidal defect was associated with transethmoidal and orbital cephalocele as well as inferolateral herniation of the frontal lobe. In spite of the large defect, the individual did not have any symptoms or complications resulting from the osteopathy. We review the current knowledge of the pathogenesis and management of cranial bone dysplasia in NF1. Copyright © 2018 Elsevier Inc. All rights reserved.

[Effect of NF-κB activation on the radiation response of esophageal cancer cells].

PubMed

Li, Baozhong; Chen, Zhaoli; Zhou, Fang; He, Jie

2014-07-01

To investigate the effect of NF-κB activation on radiation response of esophageal carcinoma. The expression of NF-κB was detected in pretreatment and posttreatment specimens of patients with ESCC by immunohistochemistry. Electrophoretic mobility shift assay (EMSA) and Western blot were used to detect the activation of NF-κB in esophageal cancer cell line KYSE150 cells. SN50, a specific NF-κB inhibitor, was applied to inhibit the activation of NF-κB. Clone formation test was used to detect the radiosensitivity of esophageal cancer cells. The median survival time of patients with activated and inactivated NF-κB in the pretreatment specimens were 16 and 19 months, respectively, with a non-significant difference between the two groups (P > 0.05). As to the patients with activated and inactivated NF-κB in posttreatment specimens, the median survival times were 13 and 35 months, respectively, with a significant difference (P < 0.01) between them. Western blot showed that the cytoplasmic expression of NF-κB was reduced with increasing radiation dose at 1.5 and 3 hours after radiation treatment. However, the expression of NF-κB in the cell nuclei was increased under the same condition, showing a trend of increased nucleus/cytoplasm ratio. The clone number in SN50 group was 96.66, 64.66, 76.66 and 10.00 under 0, 2, 4 and 12 Gy irradiation, which demonstrated a significant difference compared with the control groups (P < 0.001). Our results show that activation of NF-κB is induced by radiotherapy. Activation of NF-κB reduces the outcome of radiation treatment of esophageal cancer patients.

Molecular Regulation of Endothelial Cells by NF-1

DTIC Science & Technology

2012-07-01

disease. Patients with NF1 disease make up a significant portion of all those patients presenting with renal artery stenosis and early-onset cerebral...affected individuals can be quite variable. Perhaps the most common is renal artery stenosis and hypertension. The renal artery is also a site of...aneurysms and aortic coarctation (Zochodne 1984). Recently a model was developed in the Epstein lab where NF1 was knocked out specifically in the smooth

Combinatorial Therapy Approaches for NF2-Deficient Meningiomas

DTIC Science & Technology

2013-06-01

led to the formation of hepatocellular carcinoma and bile duct hamartoma, strongly suggesting a role for theHippo pathway in carcinogenesis. The core...CNS Oncology, Vol. 1, No. 2, Pages 113-115, 2012 mouse liver , Zhang and colleagues defined a functional role between Merlin/NF2 tumor...suppressor and the Hippo pathway. The inactivation of Nf2 in the mouse liver led to YAP1 activation and to the formation of hepatocellular carcinoma [6

Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms

PubMed Central

Choi, Grace; Huang, Brian; Pinarbasi, Emile; Braunstein, Steve E.; Horvai, Andrew E.; Kogan, Scott; Bhatia, Smita; Faddegon, Bruce; Nakamura, Jean L.

2013-01-01

Second malignant neoplasms (SMNs) are therapy-induced malignancies and a growing problem in cancer survivors, particularly survivors of childhood cancers. The lack of experimental models of SMNs has limited understanding of their pathogenesis. It is currently not possible to predict or prevent this devastating late complication. Individuals with Neurofibromatosis I (NF1) are at increased risk of developing therapy-induced cancers for unclear reasons. To model SMNs, we replicated clinical radiotherapy and delivered fractionated abdominal irradiation to Nf1+/− and wildtype mice. Similar to irradiated cancer survivors, irradiated wildtype and Nf1+/− mice developed diverse in-field malignancies. In Nf1+/− mice, fractionated irradiation promoted both classical NF1-associated malignancies and malignancies unassociated with the NF1 syndrome but typical of SMNs. Nf1 heterozygosity potentiated the mutagenic effects of irradiation, as evidenced by the significantly reduced survival after irradiation and tumor development that was often characterized by synchronous primary tumors. Interestingly, diverse radiation-induced tumors arising in wildtype and Nf1+/− mice shared a genetic signature characterized by monoallelic loss of Nf1 and the adjacent Trp53 allele. These findings implicate Nf1 loss as mediating tumorigenesis in a broad range of cell types and organs extending beyond the classical NF1 tumor histologies. Examining clinical SMN samples, we found LOH of NF1 in SMNs from non-NF1 patients. Nf1 heterozygosity confers broad susceptibility to genotoxin-induced tumorigenesis and this paradigm serves as an experimental platform for future studies of SMNs. PMID:23071067

A new nonsense mutation in the NF1 gene with neurofibromatosis-Noonan syndrome phenotype.

PubMed

Yimenicioğlu, Sevgi; Yakut, Ayten; Karaer, Kadri; Zenker, Martin; Ekici, Arzu; Carman, Kürşat Bora

2012-12-01

Neurofibromatosis-Noonan syndrome is a rare autosomal dominant disorder which combines neurofibromatosis type 1 (NF1) features with Noonan syndrome. NF1 gene mutations are reported in the majority of these patients. Sequence analysis of the established genes for Noonan syndrome revealed no mutation; a heterozygous NF1 point mutation c.7549C>T in exon 51, creating a premature stop codon (p.R2517X), had been demonstrated. Neurofibromatosis-Noonan syndrome recently has been considered a subtype of NF1 and caused by different NF1 mutations. We report the case of a 14-year-old boy with neurofibromatosis type 1 with Noonan-like features, who complained of headache with triventricular hydrocephaly and a heterozygous NF1 point mutation c.7549C>T in exon 51.

The Nuclear Signaling of NF-κB – Current Knowledge, New Insights, and Future Perspectives

PubMed Central

Wan, Fengyi; Lenardo, Michael J.

2011-01-01

The nuclear factor-kappa B (NF-κB) transcription factor plays a critical role in diverse cellular processes associated with proliferation, cell death, development, as well as innate and adaptive immune responses. NF-κB is normally sequestered in the cytoplasm by a family of inhibitory proteins known as IκBs. The signal pathways leading to the liberation and nuclear accumulation of NF-κB, which can be activated by a wide variety of stimuli, have been extensively studied in the past two decades. After gaining access to the nucleus, NF-κB must be actively regulated to execute its fundamental function as a transcription factor. Recent studies have highlighted the importance of nuclear signaling in the regulation of NF-κB transcriptional activity. A non-Rel subunit of NF-κB, ribosomal protein S3 (RPS3), and numerous other nuclear regulators of NF-κB including Akirin, Nurr1, SIRT6, and others, have recently been identified, unveiling novel and exciting layers of regulatory specificity for NF-κB in the nucleus. Further insights into the nuclear events that govern NF-κB function will deepen our understanding of the elegant control of its transcriptional activity and better inform the potential rational design of therapeutics for NF-κB-associated diseases. PMID:19997086

Gene variants in the NF-KB pathway (NFKB1, NFKBIA, NFKBIZ) and their association with type 2 diabetes and impaired renal function.

PubMed

Coto, Eliecer; Díaz-Corte, Carmen; Tranche, Salvador; Gómez, Juan; Alonso, Belén; Iglesias, Sara; Reguero, Julián R; López-Larrea, Carlos; Coto-Segura, Pablo

2018-06-01

The NF-kappaB pathway might play a role in the pathogenesis of renal disease and type 2 diabetes (T2DM). Our aim was to determine whether common polymorphisms in NF-kappaB genes were associated with impaired renal function and T2DM in a cohort of healthy elderly individuals. We studied 487 individuals, all Caucasian and aged 65-85 years. A total of 104 (21%) had impaired renal function (estimated glomerular filtration rate, eGFR < 60) and 146 (30%) were classified as diabetics. The genotypes of 4 common variants were determined through PCR-RFLP or fluorescent capillary electrophoresis. The NFKB1 variants were significantly associated with T2DM: rs7667496 p = 0.01, OR = 1.68; and rs28362491 p = 0.02, OR = 1.67. They remained significantly associated in a multiple logistic regression with age, gender, hypertension, body mass index, and cholesterol. There was a trend toward the association of these variants with eGFR < 60. The two NFKB1 variants were in linkage disequilibrium (D' = -0.86), and homozygous for the two non-risk alleles (rs7667496 CC + rs28362491 II), were significantly more common in the non-diabetics (p = 0.02). In our cohort the NFKB1 variation was an independent risk factor for developing T2DM. Additional studies to confirm this association are of special interest, as well as studies to give a functional explanation to the genetic association. Copyright © 2018 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

New York and New Jersey as seen from STS-58

NASA Technical Reports Server (NTRS)

1993-01-01

Fall colors in the northeast were captured by the STS-58 crew members. Long Island and the lower Hudson River dominate this scene. The maples and oaks of the Hudson Highlands are striking, and contrast with the many lakes and reservoirs north of the city. The New York metropolitan area in New York and New Jersey (including Jersey City and Newark) is easily seen in the foreground. Manhattan Island sits near the middle of the scene, but Central Park foliage is still fairly green. West Point can be seen near the upper right, on the west-pointing bend of the Hudson, and the Catskills are in the far upper left.

Fishing for improvements: managing fishing by boat on New York City water supply reservoirs and lakes

Treesearch

Nicole L. Green; Jennifer A. Cairo

2008-01-01

In 2003, the New York City Department of Environmental Protection Bureau of Water Supply undertook a 5-year initiative to improve fishing by boat on its water supply reservoirs and controlled lakes in upstate New York. The project includes: revising administrative procedures; cleaning up boat fishing areas on reservoir shores; improving two-way communication with...

Targeting Signaling to YAP for the Therapy of NF2

DTIC Science & Technology

2015-10-01

clear mechanism of Merlin’s tumor suppressor function. Our studies have shown that inactivation of Merlin/NF2 de-regulates the E3 ubiquitin ligase...Keywords NF2, E3 ubiquitin ligase, high throughput small molecule screening, targeted therapy. 6 Accomplishment Major goals and objectives

The Alternative NF-κB Pathway in Regulatory T Cell Homeostasis and Suppressive Function.

PubMed

Grinberg-Bleyer, Yenkel; Caron, Rachel; Seeley, John J; De Silva, Nilushi S; Schindler, Christian W; Hayden, Matthew S; Klein, Ulf; Ghosh, Sankar

2018-04-01

CD4 + Foxp3 + regulatory T cells (Tregs) are essential regulators of immune responses. Perturbation of Treg homeostasis or function can lead to uncontrolled inflammation and autoimmunity. Therefore, understanding the molecular mechanisms involved in Treg biology remains an active area of investigation. It has been shown previously that the NF-κB family of transcription factors, in particular, the canonical pathway subunits, c-Rel and p65, are crucial for the development, maintenance, and function of Tregs. However, the role of the alternative NF-κB pathway components, p100 and RelB, in Treg biology remains unclear. In this article, we show that conditional deletion of the p100 gene, nfkb2 , in Tregs, resulted in massive inflammation because of impaired suppressive function of nfkb2 -deficient Tregs. Surprisingly, mice lacking RelB in Tregs did not exhibit the same phenotype. Instead, deletion of both relb and nfkb2 rescued the inflammatory phenotype, demonstrating an essential role for p100 as an inhibitor of RelB in Tregs. Our data therefore illustrate a new role for the alternative NF-κB signaling pathway in Tregs that has implications for the understanding of molecular pathways driving tolerance and immunity. Copyright © 2018 by The American Association of Immunologists, Inc.

STS103-S-002

NASA Image and Video Library

1999-08-01

STS103-S-002 (August 1999) --- These seven astronauts have been assigned as crew members for NASA's third servicing mission to the Hubble Space Telescope (HST). They are, from the left, astronauts C. Michael Foale, Claude Nicollier, Scott J. Kelly, Curtis L. Brown, Jr., Jean-Francois Clervoy, John M. Grunsfeld and Steven L. Smith. Brown and Kelly are commander and pilot, respectively. All the others are mission specialists (MS), with international MS Nicollier and Clervoy representing the European Space Agency (ESA).

NF-kappaB activation in cancer: a challenge for ubiquitination- and proteasome-based therapeutic approach.

PubMed

Amit, Sharon; Ben-Neriah, Yinon

2003-02-01

Nuclear factor-kappa B (NF-kappaB) activation relies primarily on ubiquitin-mediated degradation of its inhibitor IkappaB. NF-kappaB plays an important role in many aspects of tumor development, progression, and therapy. Some types of cancer are characterized by constitutive NF-kappaB activity, whereas in others such activity is induced following chemotherapy. NF-kappaB-harboring tumors are generally resistant to chemotherapy and their eradication requires NF-kappaB inhibition. Here we describe the mechanisms of NF-kappaB activation in normal and tumor cells, review prevalent notions regarding the factor's contribution to tumorigenicity and discuss present and future options for NF-kappaB inhibition in cancer. The ubiquitination-mediated activation of NF-kappaB is intersected by another cancer-associated protein, beta-catenin. We, therefore, compare the related activation pathways and discuss the possibility of differential targeting of the involved ubiquitination machinery. Copyright 2002 Elsevier Science Ltd.

Overexpression of the transcription factor NF-YC9 confers abscisic acid hypersensitivity in Arabidopsis.

PubMed

Bi, Chao; Ma, Yu; Wang, Xiao-Fang; Zhang, Da-Peng

2017-11-01

Nuclear factor Y (NF-Y) family proteins are involved in many developmental processes and responses to environmental cues in plants, but whether and how they regulate phytohormone abscisic acid (ABA) signaling need further studies. In the present study, we showed that over-expression of the NF-YC9 gene confers ABA hypersensitivity in both the early seedling growth and stomatal response, while down-regulation of NF-YC9 does not affect ABA response in these processes. We also showed that over-expression of the NF-YC9 gene confers salt and osmotic hypersensitivity in early seedling growth, which is likely to be directly associated with the ABA hypersensitivity. Further, we observed that NF-YC9 physically interacts with the ABA-responsive bZIP transcription factor ABA-INSENSITIVE5 (ABI5), and facilitates the function of ABI5 to bind and activate the promoter of a target gene EM6. Additionally, NF-YC9 up-regulates expression of the ABI5 gene in response to ABA. These findings show that NF-YC9 may be involved in ABA signaling as a positive regulator and likely functions redundantly together with other NF-YC members, and support the model that the NF-YC9 mediates ABA signaling via targeting to and aiding the ABA-responsive transcription factors such as ABI5.

The U.S. Geological Survey's water resources program in New York

USGS Publications Warehouse

Wiltshire, Denise A.

1983-01-01

The U.S. Geological Survey performs hydrologic investigations throughout the United States to appraise the Nation's water resources. The Geological Survey began its water-resources investigations in New York in 1895. To meet the objectives of assessing New York's water resources, the Geological Survey (1) monitors the quantity and quality of surface and ground water, (2) conducts investigations of the occurrence, availability, and chemical quality of water in specific areas of the State, (3) develops methods and techniques of data-collection and interpretation, (4) provides scientific guidance to the research community, to Federal, State, and local governments, and to the public, and (5) disseminates data and results of research through reports, maps, news releases, conferences, and workshops. Many of the joint hydrologic investigations are performed by the Geological Survey in cooperation with State, county, and nonprofit organizations. The data collection network in New York includes nearly 200 gaging stations and 250 observation wells; chemical quality of water is measured at 260 sites. Data collected at these sites are published annually and are filed in the WATSTORE computer system. Some of the interpretive studies performed by the Geological Survey in New York include (1) determining the suitability of ground-water reservoirs for public-water supply in urban areas, (2) assessing geohydrologic impacts of leachate from hazardous waste sites on stream and ground-water quality, (3) evaluating the effects of precipitation quality and basin characteristics on streams and lakes, and (4) developing digital models of the hydrology of aquifers to simulate ground-water flow and the interaction between ground water and streams.

48 CFR 2834.002 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... MAJOR SYSTEM ACQUISITION General 2834.002 Policy. In accordance with Pub. L. 98-577, the Small Business...-cycle cost is in excess of $100 million. (b) Major real property system. (1) By purchase, when the..., although by virtue of the life cycle costs, it would otherwise be identified as “major” in response to OMB...

Redox Regulation of NF-κB p50 and M1 Polarization in Microglia

PubMed Central

Taetzsch, Thomas; Levesque, Shannon; McGraw, Constance; Brookins, Savannah; Luqa, Rafy; Bonini, Marcelo G.; Mason, Ronald P.; Oh, Unsong; Block, Michelle L.

2014-01-01

Redox-signaling is implicated in deleterious microglial activation underlying CNS disease, but how ROS program aberrant microglial function is unknown. Here, the oxidation of NF-κB p50 to a free radical intermediate is identified as a marker of dysfunctional M1 (pro-inflammatory) polarization in microglia. Microglia exposed to steady fluxes of H2O2 showed altered NF-κB p50 protein-protein interactions, decreased NF-κB p50 DNA binding, and augmented late-stage TNFα expression, indicating that H2O2 impairs NF-κB p50 function and prolongs amplified M1 activation. NF-κB p50−/− mice and cultures exhibited a disrupted M2 (alternative) response and impaired resolution of the M1 response. Persistent neuroinflammation continued 1 week after LPS (1mg/kg, IP) administration in the NF-κB p50−/− mice. However, peripheral inflammation had already resolved in both strains of mice. Treatment with the spin-trap DMPO mildly reduced LPS-induced 22 h TNFα in the brain in NF-κB p50+/+ mice. Interestingly, DMPO failed to reduce and strongly augmented brain TNFα production in NF-κB p50−/− mice, implicating a fundamental role for NF-κB p50 in the regulation of chronic neuroinflammation by free radicals. These data identify NF-κB p50 as a key redox-signaling mechanism regulating the M1/M2 balance in microglia, where loss of function leads to a CNS-specific vulnerability to chronic inflammation. PMID:25331559

NF-κB as a Therapeutic Target in Inflammatory-Associated Bone Diseases.

PubMed

Lin, T-H; Pajarinen, J; Lu, L; Nabeshima, A; Cordova, L A; Yao, Z; Goodman, S B

Inflammation is a defensive mechanism for pathogen clearance and maintaining tissue homeostasis. In the skeletal system, inflammation is closely associated with many bone disorders including fractures, nonunions, periprosthetic osteolysis (bone loss around orthopedic implants), and osteoporosis. Acute inflammation is a critical step for proper bone-healing and bone-remodeling processes. On the other hand, chronic inflammation with excessive proinflammatory cytokines disrupts the balance of skeletal homeostasis involving osteoblastic (bone formation) and osteoclastic (bone resorption) activities. NF-κB is a transcriptional factor that regulates the inflammatory response and bone-remodeling processes in both bone-forming and bone-resorption cells. In vitro and in vivo evidences suggest that NF-κB is an important potential therapeutic target for inflammation-associated bone disorders by modulating inflammation and bone-remodeling process simultaneously. The challenges of NF-κB-targeting therapy in bone disorders include: (1) the complexity of canonical and noncanonical NF-κB pathways; (2) the fundamental roles of NF-κB-mediated signaling for bone regeneration at earlier phases of tissue damage and acute inflammation; and (3) the potential toxic effects on nontargeted cells such as lymphocytes. Recent developments of novel inhibitors with differential approaches to modulate NF-κB activity, and the controlled release (local) or bone-targeting drug delivery (systemic) strategies, have largely increased the translational application of NF-κB therapy in bone disorders. Taken together, temporal modulation of NF-κB pathways with the combination of recent advanced bone-targeting drug delivery techniques is a highly translational strategy to reestablish homeostasis in the skeletal system. © 2017 Elsevier Inc. All rights reserved.