Sample records for zak jrg gelbrecht

  1. Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib

    PubMed Central

    Mathea, Sebastian; Abdul Azeez, Kamal R.; Salah, Eidarus; Tallant, Cynthia; Wolfreys, Finn; Konietzny, Rebecca; Fischer, Roman; Lou, Hua Jane; Brennan, Paul E.; Schnapp, Gisela; Pautsch, Alexander; Kessler, Benedikt M.; Turk, Benjamin E.; Knapp, Stefan

    2017-01-01

    The mixed lineage kinase ZAK is a key regulator of the MAPK pathway mediating cell survival and inflammatory response. ZAK is targeted by several clinically approved kinase inhibitors, and inhibition of ZAK has been reported to protect from doxorubicin-induced cardiomyopathy. On the other hand, unintended targeting of ZAK has been linked to severe adverse effects such as the development of cutaneous squamous cell carcinoma. Therefore, both specific inhibitors of ZAK, as well as anticancer drugs lacking off-target activity against ZAK, may provide therapeutic benefit. Here we report the first crystal structure of ZAK in complex with the B-RAF inhibitor vemurafenib. The co-crystal structure displayed a number of ZAK-specific features including a highly distorted P loop conformation enabling rational inhibitor design. Positional scanning peptide library analysis revealed a unique substrate specificity of the ZAK kinase including unprecedented preferences for histidine residues at positions −1 and +2 relative to the phosphoacceptor site. In addition, we screened a library of clinical kinase inhibitors identifying several inhibitors that potently inhibit ZAK, demonstrating that this kinase is commonly mistargeted by currently used anticancer drugs. PMID:26999302

  2. ERβ targets ZAK and attenuates cellular hypertrophy via SUMO-1 modification in H9c2 cells.

    PubMed

    Pai, Peiying; Shibu, Marthandam Asokan; Chang, Ruey-Lin; Yang, Jaw-Ji; Su, Chia-Chi; Lai, Chao-Hung; Liao, Hung-En; Viswanadha, Vijaya Padma; Kuo, Wei-Wen; Huang, Chih-Yang

    2018-06-22

    Aberrant expression of leucine zipper- and sterile ɑ motif-containing kinase (ZAK) observed in pathological human myocardial tissue is associated with the progression and elevation of hypertrophy. Our previous reports have correlated high levels of estrogen (E2) and abundant estrogen receptor (ER) α with a low incidence of pathological cardiac-hypertrophy and heart failure in the premenopause female population. However, the effect of elevated ERβ expression is not well known yet. Therefore, in this study, we have analyzed the cardioprotective effects and mechanisms of E2 and/or ERβ against ZAK overexpression-induced cellular hypertrophy. We have used transient transfection to overexpress ERβ into the ZAK tet-on H9c2 cells that harbor the doxycycline-inducible ZAK plasmid. The results show that ZAK overexpression in H9c2 cells resulted in hypertrophic effects, which was correlated with the upregulation of p-JNK and p-p38 MAPKs and their downstream transcription factors c-Jun and GATA-4. However, ERβ and E2 with ERβ overexpressions totally suppressed the effects of ZAK overexpression and inhibited the levels of p-JNK, p-p38, c-Jun, and GATA-4 effectively. Our results further reveal that ERβ directly binds with ZAK under normal conditions; however, ZAK overexpression reduced the association of ZAK-ERβ. Interestingly, increase in ERβ and E2 along with ERβ overexpression both enhanced the binding strengths of ERβ and ZAK and reduced the ZAK protein level. ERβ overexpression also suppressed the E3 ligase-casitas B-lineage lymphoma (CBL) and attenuated CBL-phosphoinositide 3-kinase (PI3K) protein association to prevent PI3K protein degradation. Moreover, ERβ and/or E2 blocked ZAK nuclear translocation via the inhibition of small ubiquitin-like modifier (SUMO)-1 modification. Taken together, our results further suggest that ERβ overexpression strongly suppresses ZAK-induced cellular hypertrophy and myocardial damage. © 2018 Wiley Periodicals, Inc.

  3. Registration of Zak ERA8 soft white spring wheat germplasm with enhanced response to ABA and increased seed dormancy

    USDA-ARS?s Scientific Manuscript database

    ZakERA8 is a unique mutant line selected from mutagenized soft white spring 'Zak' that has increased seed dormancy as a result of enhanced responsiveness to the plant hormone abscisic acid (ABA) during germination. This germplasm was developed by USDA-ARS, Pullman, WA in collaboration with Washingt...

  4. Zak phase and band inversion in dimerized one-dimensional locally resonant metamaterials

    NASA Astrophysics Data System (ADS)

    Zhu, Weiwei; Ding, Ya-qiong; Ren, Jie; Sun, Yong; Li, Yunhui; Jiang, Haitao; Chen, Hong

    2018-05-01

    The Zak phase, which refers to Berry's phase picked up by a particle moving across the Brillouin zone, characterizes the topological properties of Bloch bands in a one-dimensional periodic system. Here the Zak phase in dimerized one-dimensional locally resonant metamaterials is investigated. It is found that there are some singular points in the bulk band across which the Bloch states contribute π to the Zak phase, whereas in the rest of the band the contribution is nearly zero. These singular points associated with zero reflection are caused by two different mechanisms: the dimerization-independent antiresonance of each branch and the dimerization-dependent destructive interference in multiple backscattering. The structure undergoes a topological phase-transition point in the band structure where the band inverts, and the Zak phase, which is determined by the numbers of singular points in the bulk band, changes following a shift in dimerization parameter. Finally, the interface state between two dimerized metamaterial structures with different topological properties in the first band gap is demonstrated experimentally. The quasi-one-dimensional configuration of the system allows one to explore topology-inspired new methods and applications on the subwavelength scale.

  5. Detection of Zak phases and topological invariants in a chiral quantum walk of twisted photons.

    PubMed

    Cardano, Filippo; D'Errico, Alessio; Dauphin, Alexandre; Maffei, Maria; Piccirillo, Bruno; de Lisio, Corrado; De Filippis, Giulio; Cataudella, Vittorio; Santamato, Enrico; Marrucci, Lorenzo; Lewenstein, Maciej; Massignan, Pietro

    2017-06-01

    Topological insulators are fascinating states of matter exhibiting protected edge states and robust quantized features in their bulk. Here we propose and validate experimentally a method to detect topological properties in the bulk of one-dimensional chiral systems. We first introduce the mean chiral displacement, an observable that rapidly approaches a value proportional to the Zak phase during the free evolution of the system. Then we measure the Zak phase in a photonic quantum walk of twisted photons, by observing the mean chiral displacement in its bulk. Next, we measure the Zak phase in an alternative, inequivalent timeframe and combine the two windings to characterize the full phase diagram of this Floquet system. Finally, we prove the robustness of the measure by introducing dynamical disorder in the system. This detection method is extremely general and readily applicable to all present one-dimensional platforms simulating static or Floquet chiral systems.

  6. Detection of Zak phases and topological invariants in a chiral quantum walk of twisted photons

    PubMed Central

    Cardano, Filippo; D’Errico, Alessio; Dauphin, Alexandre; Maffei, Maria; Piccirillo, Bruno; de Lisio, Corrado; De Filippis, Giulio; Cataudella, Vittorio; Santamato, Enrico; Marrucci, Lorenzo; Lewenstein, Maciej; Massignan, Pietro

    2017-01-01

    Topological insulators are fascinating states of matter exhibiting protected edge states and robust quantized features in their bulk. Here we propose and validate experimentally a method to detect topological properties in the bulk of one-dimensional chiral systems. We first introduce the mean chiral displacement, an observable that rapidly approaches a value proportional to the Zak phase during the free evolution of the system. Then we measure the Zak phase in a photonic quantum walk of twisted photons, by observing the mean chiral displacement in its bulk. Next, we measure the Zak phase in an alternative, inequivalent timeframe and combine the two windings to characterize the full phase diagram of this Floquet system. Finally, we prove the robustness of the measure by introducing dynamical disorder in the system. This detection method is extremely general and readily applicable to all present one-dimensional platforms simulating static or Floquet chiral systems. PMID:28569741

  7. The Multiplicative Zak Transform, Dimension Reduction, and Wavelet Analysis of LIDAR Data

    DTIC Science & Technology

    2010-01-01

    systems is likely to fail. Auslander, Eichmann , Gertner, and Tolimieri defined a multiplicative Zak transform [1], mimicking the construction of the Gabor...L. Auslander, G. Eichmann , I. Gertner and R. Tolimieri, “Time-Frequency Analysis and Synthesis of Non-Stationary Signals,” Proc. Soc. Photo-Opt. In

  8. CWC Industry Outreach III: Chemical Weapons Convention Ratification, Implementation, Compliance and Verification (CWC Video). Volume 2. Annexes.

    DTIC Science & Technology

    1995-08-01

    7515 (818) 791-8805 (FAX) (415) 742-7540 (FAX) CHEVRON CORPORATION HUISH DETERGENTS, INC. CHARLOTTE R. FARBER DON GOLLADAY 225 BUSH STREET P.O. BOX 25057...USA) TEXAS INSTRUMENTS KENT BOSSART ZAK KARAMALLY 1701 PENNSYLVANIA AVE., NW #500 TEXAS INSTRUMENTS WASHINGTON, DC 20006 ZAK KARAMALLY 202-861-0668 P

  9. To Make a Male: What Does It Take?

    ERIC Educational Resources Information Center

    Elfer, Jane; Lee, Anthony

    2009-01-01

    This article presents a case study of a year of psychotherapeutic work by a female and male therapist with a 14-year-old boy born with ambiguous genitalia. His mother was also present in the sessions at the request of Zak. We describe the early trauma surrounding Zak's birth and the subsequent desertion of a violent father. We present the…

  10. Zak phase induced multiband waveguide by two-dimensional photonic crystals.

    PubMed

    Yang, Yuting; Xu, Tao; Xu, Yun Fei; Hang, Zhi Hong

    2017-08-15

    Interface states in photonic crystals provide efficient approaches to control the flow of light. Photonic Zak phase determines the bulk band properties of photonic crystals, and, by assembling two photonic crystals with different bulk band properties together, deterministic interface states can be realized. By translating each unit cell of a photonic crystal by half the lattice constant, another photonic crystal with identical common gaps but a different Zak phase at each photonic band can be created. By assembling these two photonic crystals together, multiband waveguide can thus be easily created and then experimentally characterized. Our experimental results have good agreement with numerical simulations, and the propagation properties of these measured interface states indicate that this new type of interface state will be a good candidate for future applications of optical communications.

  11. Surface to bulk Fermi arcs via Weyl nodes as topological defects

    PubMed Central

    Kim, Kun Woo; Lee, Woo-Ram; Kim, Yong Baek; Park, Kwon

    2016-01-01

    A hallmark of Weyl semimetal is the existence of surface Fermi arcs. An intriguing question is what determines the connectivity of surface Fermi arcs, when multiple pairs of Weyl nodes are present. To answer this question, we show that the locations of surface Fermi arcs are predominantly determined by the condition that the Zak phase integrated along the normal-to-surface direction is . The Zak phase can reveal the peculiar topological structure of Weyl semimetal directly in the bulk. Here, we show that the winding of the Zak phase around each projected Weyl node manifests itself as a topological defect of the Wannier–Stark ladder, energy eigenstates under an electric field. Remarkably, this leads to bulk Fermi arcs, open-line segments in the bulk spectra. Bulk Fermi arcs should exist in conjunction with surface counterparts to conserve the Weyl fermion number under an electric field, which is supported by explicit numerical evidence. PMID:27845342

  12. Antitumorigenic Effects of ZAKβ, an Alternative Splicing Isoform of ZAK.

    PubMed

    Lee, Jin-Sun; Lin, Yuh-Yih; Wang, Tsu-Shing; Liu, Jer-Yuh; Lin, Wei-Wen; Yang, Jaw-Ji

    2018-02-28

    Sterile alpha motif (SAM)- and leucine-zipper-containing kinase (ZAK) plays a role in the regulation of cell cycle progression and oncogenic transformation. The ZAK gene generates two transcript variants, ZAKα and ZAKβ, through alternative splicing. In this study, we identified that ZAKα proteins were upregulated in tumor tissues, whereas ZAKβ proteins were mostly expressed in corresponding normal tissues. The ectopically expressed ZAKβ proteins in cancer cells inhibited cancer cell proliferation as well as anchorage-independent growth. The ZAKβ:ZAKα protein ratio played a role in the regulation of the cyclic adenosine monophosphate (cAMP) signaling pathway, whereas high ZAKβ protein levels led to the activation of cAMP response element binding protein 1 (CREB1) and exerted antitumor properties. Overexpression of ZAKβ or CREB1 cDNAs in cancer cells inhibited anchorage-independent growth and also reduced the levels of cyclooxygenase 2 (Cox2) and β-catenin proteins. Cancer cells treated with doxorubicin (Doxo) resulted in the switching from the expression of ZAKα to ZAKβ and also inhibited cancer cell growth in soft agar, demonstrating that pharmacological drugs could be used to manipulate endogenous reprogramming splicing events and resulting in the activation of endogenous antitumorigenic properties. We showed that the two ZAK transcript variants, ZAKα and ZAKβ, had opposite biological functions in the regulation of tumor cell proliferation in that ZAKβ had powerful antitumor properties and that ZAKα could promote tumor growth.

  13. Recommended Replacements for Tetryl in Australian Production Fuzes and Related Ordnance,

    DTIC Science & Technology

    1987-11-01

    RDX/AC629 as lead filling confirms comparable or better performance by RDX/AC629 on either of the RDX-based boosters. A -5 leads in Fuze M739 are... S . zinc stearate/graphite 98.0:1.25:0.5:0.25 Comparison: Debrix 18AS 120 1.496 a Extrapolated from data for 98.94:1.06 and 98.69:1.31 formulations...71P 8 1 ~ Aq CENEN on FO A R IAN L/I t A IF. I 4JrgALs RLj A ) R SF L. 6UN~cLASSIFIED -- IM DO AA - 14 F/G 19/1 NL . 1I.. EL6 ’ I lin MRL-R-.lO89 AR

  14. SAR (Synthetic Aperture Radar) Data Collection and Processing Summary - 1984 SARSEX (SAR Internal Wave Signature Experiment) Experiment.

    DTIC Science & Technology

    1985-03-01

    DIVISION ;! -0 N xr-0 n 0n4 1 1 I- C) 0 Ic 0 C WIx W Qr - - r -r 01............................. I Cq I1 -a I- I X 0’ an w I w kI~r 1 0r- r- r . 0~~~ Cs CW 1...object from the SAR platform . Ground range, the 102 ~RIM RADAR DIVISION 0 0 sc 0’. C4 C4 Xn en % >4-4 441i V-u -- - W 1-11 04 v4 0o 0 4 0 (A~U Go 4J...Rg = rRF -hy ,(3) for the flat earth or low-altitude case, where h is the platform altitude. Because the range and azimuth scales are not the same

  15. [Sanitation of the health service centre in Warsaw (Samodzielny Zespół Publicznych Zakładów Lecznictwa Otwartego Warszawa-Mokotów). Financial and economic analysis].

    PubMed

    Buczak-Stec, Elzbieta

    2010-01-01

    The aim of the financial and economic analysis, conducted in March 2010, was to identify all significant factors that had a positive influence on the restructuring process in the health service centre (Samodzielny Zespół Publicznych Zakładów Lecznictwa Otwartego Warszawa--Mokotów) in Warsaw. Within the framework of the analysis, financial data form time period 1999-2009 were analyzed. Also the managing director and financial director were interviewed. Taking into consideration research results it can be stated that not a single factor but a collection of the purposeful efforts influenced the improvement of the health service centre condition. Apart from received public help, the most significant factors include: rational restructuring process, managing of personnel development, professionally managed financial department, cooperation between departments, good internal communication and use of modern management techniques.

  16. Response to Rollock

    ERIC Educational Resources Information Center

    Woods, Ruth

    2008-01-01

    This article presents the author's response to Nicola Rollock's critique on the author's paper in which the author has argued that ethnographic data should be more widely used in psychology (Woods 2005, 2007b). Rollock argues that the paper neglects Zak's level of educational achievement, and fails to critically interrogate his teachers' actions…

  17. BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling

    PubMed Central

    Vin, Harina; Ojeda, Sandra S; Ching, Grace; Leung, Marco L; Chitsazzadeh, Vida; Dwyer, David W; Adelmann, Charles H; Restrepo, Monica; Richards, Kristen N; Stewart, Larissa R; Du, Lili; Ferguson, Scarlett B; Chakravarti, Deepavali; Ehrenreiter, Karin; Baccarini, Manuela; Ruggieri, Rosamaria; Curry, Jonathan L; Kim, Kevin B; Ciurea, Ana M; Duvic, Madeleine; Prieto, Victor G; Ullrich, Stephen E; Dalby, Kevin N; Flores, Elsa R; Tsai, Kenneth Y

    2013-01-01

    Vemurafenib and dabrafenib selectively inhibit the v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) kinase, resulting in high response rates and increased survival in melanoma. Approximately 22% of individuals treated with vemurafenib develop cutaneous squamous cell carcinoma (cSCC) during therapy. The prevailing explanation for this is drug-induced paradoxical ERK activation, resulting in hyperproliferation. Here we show an unexpected and novel effect of vemurafenib/PLX4720 in suppressing apoptosis through the inhibition of multiple off-target kinases upstream of c-Jun N-terminal kinase (JNK), principally ZAK. JNK signaling is suppressed in multiple contexts, including in cSCC of vemurafenib-treated patients, as well as in mice. Expression of a mutant ZAK that cannot be inhibited reverses the suppression of JNK activation and apoptosis. Our results implicate suppression of JNK-dependent apoptosis as a significant, independent mechanism that cooperates with paradoxical ERK activation to induce cSCC, suggesting broad implications for understanding toxicities associated with BRAF inhibitors and for their use in combination therapies. DOI: http://dx.doi.org/10.7554/eLife.00969.001 PMID:24192036

  18. Doxorubicin induces ZAKα overexpression with a subsequent enhancement of apoptosis and attenuation of survivability in human osteosarcoma cells.

    PubMed

    Fu, Chien-Yao; Tseng, Yan-Shen; Chen, Ming-Cheng; Hsu, Hsi-Hsien; Yang, Jaw-Ji; Tu, Chuan-Chou; Lin, Yueh-Min; Viswanadha, Vijaya Padma; Kuo, Wei-Wen; Huang, Chih-Yang

    2018-02-01

    Human osteosarcoma (OS) is a malignant cancer of the bone. It exhibits a characteristic malignant osteoblastic transformation and produces a diseased osteoid. A previous study demonstrated that doxorubicin (DOX) chemotherapy decreases human OS cell proliferation and might enhance the relative RNA expression of ZAK. However, the impact of ZAKα overexpression on the OS cell proliferation that is inhibited by DOX and the molecular mechanism underlying this effect are not yet known. ZAK is a protein kinase of the MAPKKK family and functions to promote apoptosis. In our study, we found that ZAKα overexpression induced an apoptotic effect in human OS cells. Treatment of human OS cells with DOX enhanced ZAKα expression and decreased cancer cell viability while increasing apoptosis of human OS cells. In the meantime, suppression of ZAKα expression using shRNA and inhibitor D1771 both suppressed the DOX therapeutic effect. These findings reveal a novel molecular mechanism underlying the DOX effect on human OS cells. Taken together, our findings demonstrate that ZAKα enhances the apoptotic effect and decreases cell viability in DOX-treated human OS cells. © 2017 Wiley Periodicals, Inc.

  19. The Armadillo Repeat Gene ZAK IXIK Promotes Arabidopsis Early Embryo and Endosperm Development through a Distinctive Gametophytic Maternal Effect[C][W][OA

    PubMed Central

    Ngo, Quy A.; Baroux, Celia; Guthörl, Daniela; Mozerov, Peter; Collinge, Margaret A.; Sundaresan, Venkatesan; Grossniklaus, Ueli

    2012-01-01

    The proper balance of parental genomic contributions to the fertilized embryo and endosperm is essential for their normal growth and development. The characterization of many gametophytic maternal effect (GME) mutants affecting seed development indicates that there are certain classes of genes with a predominant maternal contribution. We present a detailed analysis of the GME mutant zak ixik (zix), which displays delayed and arrested growth at the earliest stages of embryo and endosperm development. ZIX encodes an Armadillo repeat (Arm) protein highly conserved across eukaryotes. Expression studies revealed that ZIX manifests a GME through preferential maternal expression in the early embryo and endosperm. This parent-of-origin–dependent expression is regulated by neither the histone and DNA methylation nor the DNA demethylation pathways known to regulate some other GME mutants. The ZIX protein is localized in the cytoplasm and nucleus of cells in reproductive tissues and actively dividing root zones. The maternal ZIX allele is required for the maternal expression of MINISEED3. Collectively, our results reveal a reproductive function of plant Arm proteins in promoting early seed growth, which is achieved through a distinct GME of ZIX that involves mechanisms for maternal allele-specific expression that are independent of the well-established pathways. PMID:23064319

  20. Pharmacological Inhibition of the Protein Kinase MRK/ZAK Radiosensitizes Medulloblastoma.

    PubMed

    Markowitz, Daniel; Powell, Caitlin; Tran, Nhan L; Berens, Michael E; Ryken, Timothy C; Vanan, Magimairajan; Rosen, Lisa; He, Mingzu; Sun, Shan; Symons, Marc; Al-Abed, Yousef; Ruggieri, Rosamaria

    2016-08-01

    Medulloblastoma is a cerebellar tumor and the most common pediatric brain malignancy. Radiotherapy is part of the standard care for this tumor, but its effectiveness is accompanied by significant neurocognitive sequelae due to the deleterious effects of radiation on the developing brain. We have previously shown that the protein kinase MRK/ZAK protects tumor cells from radiation-induced cell death by regulating cell-cycle arrest after ionizing radiation. Here, we show that siRNA-mediated MRK depletion sensitizes medulloblastoma primary cells to radiation. We have, therefore, designed and tested a specific small molecule inhibitor of MRK, M443, which binds to MRK in an irreversible fashion and inhibits its activity. We found that M443 strongly radiosensitizes UW228 medulloblastoma cells as well as UI226 patient-derived primary cells, whereas it does not affect the response to radiation of normal brain cells. M443 also inhibits radiation-induced activation of both p38 and Chk2, two proteins that act downstream of MRK and are involved in DNA damage-induced cell-cycle arrest. Importantly, in an animal model of medulloblastoma that employs orthotopic implantation of primary patient-derived UI226 cells in nude mice, M443 in combination with radiation achieved a synergistic increase in survival. We hypothesize that combining radiotherapy with M443 will allow us to lower the radiation dose while maintaining therapeutic efficacy, thereby minimizing radiation-induced side effects. Mol Cancer Ther; 15(8); 1799-808. ©2016 AACR. ©2016 American Association for Cancer Research.

  1. The Technical Problems of Anti-theft Diagnostics in a Traction Network

    NASA Astrophysics Data System (ADS)

    Mikulski, Jerzy; Młynczak, Jakub

    2012-02-01

    The paper presents an analysis of traction lines theft in the Katowice division of the Railroad Development Company (Zakład Linii Kolejowych - ZLK) as well as the principles for the anti-theft protection system, currently in development. The problem of theft is a very important issue concerning the safety of rail transportation. It is also a significant economic problem, as the cost of recreating a stolen network is very high. Moreover, the Administrator of the infrastructure bears the cost of compensation for any delays in train schedules.

  2. Technical Papers Presented at the Defense Nuclear Agency Global Effects Review Held in Santa Barbara, California on 7-9 April 1987. Volume 2

    DTIC Science & Technology

    1987-05-19

    Prescribed 341 Burn - Einfield, Zak, Mokler and Morrison 23. Measurements of Cloud Active Aerosol in Large Scale Fires - Hudson 356 24. Optical Depth...Cover A LAI change with I Leaf drop temperaturelseason STEMSilraio I R u plo oilS u r fa c e Surfctie %ooil temeraureUpper leyer wetness layer( du...Michigan can be attributed to an unforecast mesoscale region of cloudiness. The positive error region in western Tennessee and Kentucky is associated

  3. a Rigorous Comparison of Theoretical and Measured Carbon Dioxide Line Intensities

    NASA Astrophysics Data System (ADS)

    Yi, Hongming; Fleisher, Adam J.; Gameson, Lyn; Zak, Emil J.; Polyansky, Oleg; Tennyson, Jonathan; Hodges, Joseph T.

    2017-06-01

    The ability to calculate molecular line intensities from first principles plays an increasingly important role in populating line-by-line spectroscopic databases because of its generality and extensibility to various isotopologues, spectral ranges and temperature conditions. Such calculations require a spectroscopically determined potential energy surface, and an accurate dipole moment surface that can be either fully ab initio or an effective quantity based on fits to measurements Following our recent work where we used high-precision measurements of intensities in the (30013 →00001) band of ^{12}C^{16}O_2 to bound the uncertainty of calculated line lists, here we carry out high-precision, frequency-stabilized cavity ring-down spectroscopy measurements in the R-branch of the ^{12}C^{16}O_2 (20012 →00001) band from J = 16 to 52. Gas samples consisted of 50 μmol mol^{-1} or 100 μmol mol^{-1} of nitrogen-broadened carbon dioxide with gravimetrically determined SI-traceable molar composition. We demonstrate relative measurement precision (Type A) at the 0.15 % level and estimate systematic (Type B) uncertainty contributions in % of: isotopic abundance 0.01; sample density, 0.016; cavity free spectral rang,e 0.03; line shape, 0.05; line interferences, 0.05; and carbon dioxide molar fraction, 0.06. Combined in quadrature, these components yield a relative standard uncertainty in measured line intensity less than 0.2 % for most observed transitions. These intensities differ by more than 2 % from those measured by Fourier transform spectroscopy and archived in HITRAN 2012 but differ by less than 0.5 % with the calculations of Zak et al. E. Zak et al., J. Quant. Spectrosc. Radiat. Transf. 177, (2016) 31. Huang et al., J. Quant. Spectrosc. Radiat. Transf. 130, (2013) 134. Tashkun et al., J. Quant. Spectrosc. Radiat. Transf. 152, (2015) 45.

  4. Synergistic Interactions with PI3K Inhibition that Induce Apoptosis. | Office of Cancer Genomics

    Cancer.gov

    Activating mutations involving the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest, leaving a significant reservoir of tumor cells that may acquire or exhibit resistance. We searched for genes that are required for the survival of PI3K mutant cancer cells in the presence of PI3K inhibition by conducting a genome scale shRNA-based apoptosis screen in a PIK3CA mutant human breast cancer cell. We identified 5 genes (PIM2, ZAK, TACC1, ZFR, ZNF565) whose suppression induced cell death upon PI3K inhibition.

  5. Renormalization of QCD in the interpolating momentum subtraction scheme at three loops

    NASA Astrophysics Data System (ADS)

    Gracey, J. A.; Simms, R. M.

    2018-04-01

    We introduce a more general set of kinematic renormalization schemes than the original momentum subtraction schemes of Celmaster and Gonsalves. These new schemes will depend on a parameter ω , which tags the external momentum of one of the legs of the three-point vertex functions in QCD. In each of the three new schemes, we renormalize QCD in the Landau and maximal Abelian gauges and establish the three-loop renormalization group functions in each gauge. For an application, we evaluate two critical exponents at the Banks-Zaks fixed point and demonstrate that their values appear to be numerically scheme independent in a subrange of the conformal window.

  6. Tamm-plasmon polaritons in one-dimensional photonic quasi-crystals.

    PubMed

    Shukla, Mukesh Kumar; Das, Ritwick

    2018-02-01

    We present an investigation to ascertain the existence of Tamm-plasmon-polariton-like modes in one-dimensional (1D) quasi-periodic photonic systems. Photonic bandgap formation in quasi-crystals is essentially a consequence of long-range periodicity exhibited by multilayers and, thus, it can be explained using the dispersion relation in the Brillouin zone. Defining a "Zak"-like topological phase in 1D quasi-crystals, we propose a recipe to ascertain the existence of Tamm-like photonic surface modes in a metal-terminated quasi-crystal lattice. Additionally, we also explore the conditions of efficient excitation of such surface modes along with their dispersion characteristics.

  7. Topological phases in a Kitaev chain with imbalanced pairing

    NASA Astrophysics Data System (ADS)

    Li, C.; Zhang, X. Z.; Zhang, G.; Song, Z.

    2018-03-01

    We systematically study a Kitaev chain with imbalanced pair creation and annihilation, which is introduced by non-Hermitian pairing terms. An exact phase diagram shows that the topological phase is still robust under the influence of the conditional imbalance. The gapped phases are characterized by a topological invariant, the extended Zak phase, which is defined by the biorthonormal inner product. Such phases are destroyed at the points where the coalescence of ground states occurs, associated with the time-reversal symmetry breaking. We find that the Majorana edge modes also exist in an open chain in the time-reversal symmetry-unbroken region, demonstrating the bulk-edge correspondence in such a non-Hermitian system.

  8. Synthesis, metabolism and systemic transport of a fluorinated mimic of the endogenous jasmonate precursor OPC-8:0.

    PubMed

    Jimenez-Aleman, Guillermo H; Scholz, Sandra S; Heyer, Monika; Reichelt, Michael; Mithöfer, Axel; Boland, Wilhelm

    2015-12-01

    Jasmonates (JAs) are fatty acid derivatives that mediate many developmental processes and stress responses in plants. Synthetic jasmonate derivatives (commonly isotopically labeled), which mimic the action of the endogenous compounds are often employed as internal standards or probes to study metabolic processes. However, stable-isotope labeling of jasmonates does not allow the study of spatial and temporal distribution of these compounds in real time by positron emission tomography (PET). In this study, we explore whether a fluorinated jasmonate could mimic the action of the endogenous compound and therefore, be later employed as a tracer to study metabolic processes by PET. We describe the synthesis and the metabolism of (Z)-7-fluoro-8-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)octanoic acid (7F-OPC-8:0), a fluorinated analog of the JA precursor OPC-8:0. Like endogenous jasmonates, 7F-OPC-8:0 induces the transcription of marker jasmonate responsive genes (JRG) and the accumulation of jasmonates after its application to Arabidopsis thaliana plants. By using UHPLC-MS/MS, we could show that 7F-OPC-8:0 is metabolized in vivo similarly to the endogenous OPC-8:0. Furthermore, the fluorinated analog was successfully employed as a probe to show its translocation to undamaged systemic leaves when it was applied to wounded leaves. This result suggests that OPC-8:0 - and maybe other oxylipins - may contribute to the mobile signal which triggers systemic defense responses in plants. We highlight the potential of fluorinated oxylipins to study the mode of action of lipid-derived molecules in planta, either by conventional analytical methods or fluorine-based detection techniques. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. Statics of wrinkling films

    NASA Technical Reports Server (NTRS)

    Zak, M.

    1982-01-01

    An analytical investigation of the equilibrium of wrinkling films is conducted. Zak (1979) has shown that wrinkling occurs in connection with the instability of a smooth film having no resistance to bending in the case of compression. The governing equation for the equilibrium of a film with possible regions of wrinkling is considered. The introduction of fictitious stress reduces the governing equation to a form which formally coincides with the governing equation for a string. Equilibrium conditions in the case of an absence of external forces are explored, taking into account the stretching of a semispherical film, the torsion of a convex film of revolution, and stress singularities. A study is conducted of the equilibrium under conditions in which external forces normal to the surface of a film are present. Attention is also given to the equilibrium in a potential field.

  10. Fuzzy model-based observers for fault detection in CSTR.

    PubMed

    Ballesteros-Moncada, Hazael; Herrera-López, Enrique J; Anzurez-Marín, Juan

    2015-11-01

    Under the vast variety of fuzzy model-based observers reported in the literature, what would be the properone to be used for fault detection in a class of chemical reactor? In this study four fuzzy model-based observers for sensor fault detection of a Continuous Stirred Tank Reactor were designed and compared. The designs include (i) a Luenberger fuzzy observer, (ii) a Luenberger fuzzy observer with sliding modes, (iii) a Walcott-Zak fuzzy observer, and (iv) an Utkin fuzzy observer. A negative, an oscillating fault signal, and a bounded random noise signal with a maximum value of ±0.4 were used to evaluate and compare the performance of the fuzzy observers. The Utkin fuzzy observer showed the best performance under the tested conditions. Copyright © 2015 ISA. Published by Elsevier Ltd. All rights reserved.

  11. Education with Infrared Astronomy and Spitzer

    NASA Astrophysics Data System (ADS)

    Hemphill, Rosa; Blackwell, J. A.; Herrold, A.; Petroff, E.

    2007-12-01

    We present education and outreach results using our experiences involving the Spitzer Space Telescope project, Star Formation in High Redshift Clusters with Spitzer. The project is a collaboration between the Spitzer Science Center and the National Optical Astronomy Observatory. Using the Spitzer Space Telescope, we measured star formation rates in three galaxy clusters at intermediate redshifts. Six teachers were chosen for the program, each with an interest and involvement in astronomy education. From this project, lesson plans, public outreach, lectures and demonstrations were generated which better the understanding of infrared astronomy, multiwavelength astronomy, galaxy and star formation, and cosmology. The teacher mentors are Dr. Gregory Rudnick (NOAO), Dr. Rose Finn (Siena College), and Dr. Vandana Desai (Caltech). Please see the companion posters by Emily Petroff, Zak Schroeder, and Thomas Loughran, et al, for information concerning the science results.

  12. Topological photonic crystals with zero Berry curvature

    NASA Astrophysics Data System (ADS)

    Liu, Feng; Deng, Hai-Yao; Wakabayashi, Katsunori

    2018-02-01

    Topological photonic crystals are designed based on the concept of Zak's phase rather than the topological invariants such as the Chern number and spin Chern number, which rely on the existence of a nonvanishing Berry curvature. Our photonic crystals (PCs) are made of pure dielectrics and sit on a square lattice obeying the C4 v point-group symmetry. Two varieties of PCs are considered: one closely resembles the electronic two-dimensional Su-Schrieffer-Heeger model, and the other continues as an extension of this analogy. In both cases, the topological transitions are induced by adjusting the lattice constants. Topological edge modes (TEMs) are shown to exist within the nontrivial photonic band gaps on the termination of those PCs. The high efficiency of these TEMs transferring electromagnetic energy against several types of disorders has been demonstrated using the finite-element method.

  13. Fractional lattice charge transport

    NASA Astrophysics Data System (ADS)

    Flach, Sergej; Khomeriki, Ramaz

    2017-01-01

    We consider the dynamics of noninteracting quantum particles on a square lattice in the presence of a magnetic flux α and a dc electric field E oriented along the lattice diagonal. In general, the adiabatic dynamics will be characterized by Bloch oscillations in the electrical field direction and dispersive ballistic transport in the perpendicular direction. For rational values of α and a corresponding discrete set of values of E(α) vanishing gaps in the spectrum induce a fractionalization of the charge in the perpendicular direction - while left movers are still performing dispersive ballistic transport, the complementary fraction of right movers is propagating in a dispersionless relativistic manner in the opposite direction. Generalizations and the possible probing of the effect with atomic Bose-Einstein condensates and photonic networks are discussed. Zak phase of respective band associated with gap closing regime has been computed and it is found converging to π/2 value.

  14. Topological phases in frustrated synthetic ladders with an odd number of legs

    NASA Astrophysics Data System (ADS)

    Barbarino, Simone; Dalmonte, Marcello; Fazio, Rosario; Santoro, Giuseppe E.

    2018-01-01

    The realization of the Hofstadter model in a strongly anisotropic ladder geometry has now become possible in one-dimensional optical lattices with a synthetic dimension. In this work, we show how the Hofstadter Hamiltonian in such ladder configurations hosts a topological phase of matter which is radically different from its two-dimensional counterpart. This topological phase stems directly from the hybrid nature of the ladder geometry and is protected by a properly defined inversion symmetry. We start our analysis by considering the paradigmatic case of a three-leg ladder which supports a topological phase exhibiting the typical features of topological states in one dimension: robust fermionic edge modes, a degenerate entanglement spectrum, and a nonzero Zak phase; then, we generalize our findings—addressable in the state-of-the-art cold-atom experiments—to ladders with a higher number of legs.

  15. Quantization of geometric phase with integer and fractional topological characterization in a quantum Ising chain with long-range interaction.

    PubMed

    Sarkar, Sujit

    2018-04-12

    An attempt is made to study and understand the behavior of quantization of geometric phase of a quantum Ising chain with long range interaction. We show the existence of integer and fractional topological characterization for this model Hamiltonian with different quantization condition and also the different quantized value of geometric phase. The quantum critical lines behave differently from the perspective of topological characterization. The results of duality and its relation to the topological quantization is presented here. The symmetry study for this model Hamiltonian is also presented. Our results indicate that the Zak phase is not the proper physical parameter to describe the topological characterization of system with long range interaction. We also present quite a few exact solutions with physical explanation. Finally we present the relation between duality, symmetry and topological characterization. Our work provides a new perspective on topological quantization.

  16. Tracking Down Batholith Construction Through Time Using Lobes From The Tuolumne Batholith, Sierra Nevada, CA.

    NASA Astrophysics Data System (ADS)

    Memeti, V.; Paterson, S. R.

    2006-12-01

    Data gained using various geologic tools from large, composite batholiths, such as the 95-85 Ma old Tuolumne Batholith (TB), Sierra Nevada, CA, indicate complex batholithic processes at the chamber construction site, in part since they record different increments of batholith construction through time. Large structural and compositional complexity generally occurs throughout the main batholith such as (1) geochemistry, (2) internal contacts between different units (Bateman, 1992; Zak &Paterson, 2005), (3) batholith/host rock contacts, (4) geochronology (Coleman et al., 2004; Matzel et al., 2005, 2006), and (5) internal structures such as schlieren layering and fabrics (Bateman, 1992; Zak et al., 2006) leading to controversies regarding batholith construction models. By using magmatic lobes tongues of individual batholithic units that extend into the host rock away from the main batholith we avoid some of the complexity that evolved over longer times within the main batholith. Magmatic lobes are "simpler" systems, because they are spatially separated from other units of the batholith and thus ideally represent processes in just one unit at the time of emplacement. Furthermore, they are shorter lived than the main batholith since they are surrounded by relatively cold host rock and "freeze in" (1) "snapshots" of batholith construction, and (2) relatively short-lived internal processes and resulting structures and composition in each individual unit. Thus, data from lobes of all batholith units representing different stages of a batholith's lifetime, help us to understand internal magmatic and external host rock processes during batholith construction. Based on field and analytic data from magmatic lobes of the Kuna Crest, Half Dome, and the Cathedral Peak granodiorites, we conclude that (1) the significance of internal processes in the lobes (fractionation versus mixing versus source heterogeneity) is unique for each individual TB unit; (2) emplacement mechanisms such as stoping, downward flow or ductile deformation of host rock act in a very short period of time (only a few 100,000 yrs); and (3) a variety of different magmatic fabrics, formed by strain caused by magma flow, marginal effects, or regional stress, can be found in each lobe. These data lead to the conclusion that the size of the studied lobes indicate the minimum pulse size for TB construction and that fractionation crystallization, even though slightly varying in its magnitude, is an important internal process in each individual TB unit.

  17. Analysis of conditions and the concept of multidirectional revitalization of the dolomite quarry in Siewierz

    NASA Astrophysics Data System (ADS)

    Pawełczyk, Katarzyna

    2018-01-01

    The development of mining of rock raw materials in Poland has significantly contributed to economic growth and the quality of life of local communities. However, mining activity, besides a number of positive effects, also implies broadly understood changes in the environment and the formation of brownfields. Reclamation and redevelopment of post-industrial areas, and especially post-mining areas, is currently a huge environmental and socio-economic challenge. Revitalization of post-mining areas is particularly important for small towns and municipalities, where mining was one of the main pillars of development and prosperity. An example of such a municipality is Siewierz in Silesian Voivodship. In the paper analysis the conditions have been conducted and the concept of revitalization of dolomite quarry Górnicze Zakłady Dolomitowe S.A. has been proposed. The AHP method has been used to analyse and select the optimal method of revitalization. As a result of the analysis, the concept of multidirectional revitalization with socially, economically and environmentally beneficial functions has been created, maximizing the potential of the quarry.

  18. Conformal expansions and renormalons

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rathsman, J.

    2000-02-07

    The coefficients in perturbative expansions in gauge theories are factorially increasing, predominantly due to renormalons. This type of factorial increase is not expected in conformal theories. In QCD conformal relations between observables can be defined in the presence of a perturbative infrared fixed-point. Using the Banks-Zaks expansion the authors study the effect of the large-order behavior of the perturbative series on the conformal coefficients. The authors find that in general these coefficients become factorially increasing. However, when the factorial behavior genuinely originates in a renormalon integral, as implied by a postulated skeleton expansion, it does not affect the conformal coefficients.more » As a consequence, the conformal coefficients will indeed be free of renormalon divergence, in accordance with previous observations concerning the smallness of these coefficients for specific observables. The authors further show that the correspondence of the BLM method with the skeleton expansion implies a unique scale-setting procedure. The BLM coefficients can be interpreted as the conformal coefficients in the series relating the fixed-point value of the observable with that of the skeleton effective charge. Through the skeleton expansion the relevance of renormalon-free conformal coefficients extends to real-world QCD.« less

  19. Long-range doublon transfer in a dimer chain induced by topology and ac fields

    NASA Astrophysics Data System (ADS)

    Bello, M.; Creffield, C. E.; Platero, G.

    2016-03-01

    The controlled transfer of particles from one site of a spatial lattice to another is essential for many tasks in quantum information processing and quantum communication. In this work we study how to induce long-range transfer between the two ends of a dimer chain, by coupling states that are localized just on the chain’s end-points. This has the appealing feature that the transfer occurs only between the end-points - the particle does not pass through the intermediate sites-making the transfer less susceptible to decoherence. We first show how a repulsively bound-pair of fermions, known as a doublon, can be transferred from one end of the chain to the other via topological edge states. We then show how non-topological surface states of the familiar Shockley or Tamm type can be used to produce a similar form of transfer under the action of a periodic driving potential. Finally we show that combining these effects can produce transfer by means of more exotic topological effects, in which the driving field can be used to switch the topological character of the edge states, as measured by the Zak phase. Our results demonstrate how to induce long range transfer of strongly correlated particles by tuning both topology and driving.

  20. The Existence of Topological Edge States in Honeycomb Plasmonic Lattices

    NASA Astrophysics Data System (ADS)

    Wang, Li

    In this paper, we investigate the band properties of 2D honeycomb plasmonic lattices consisting of metallic nanoparticles. By means of the coupled dipole method and quasi-static approximation, we theoretically analyze the band structures stemming from near-field interaction of localized surface plasmon polaritons for both the infinite lattice and ribbons. Naturally, the interaction of point dipoles decouples into independent out-of-plane and in-plane polarizations. For the out-of-plane modes, both the bulk spectrum and the range of the momentum k∥ where edge states exist in ribbons are similar to the electronic bands in graphene. Nevertheless, the in-plane polarized modes show significant differences, which do not only possess additional non-flat edge states in ribbons, but also have different distributions of the flat edge states in reciprocal space. For in-plane polarized modes, we derived the bulk-edge correspondence, namely, the relation between the number of flat edge states at a fixed k∥, Zak phases of the bulk bands and the winding number associated with the bulk hamiltonian, and verified it through four typical ribbon boundaries, i.e. zigzag, bearded zigzag, armchair, and bearded armchair. Our approach gives a new topological understanding of edge states in such plasmonic systems, and may also apply to other 2D vector wave systems.

  1. The existence of topological edge states in honeycomb plasmonic lattices

    NASA Astrophysics Data System (ADS)

    Wang, Li; Zhang, Ruo-Yang; Xiao, Meng; Han, Dezhuan; Chan, C. T.; Wen, Weijia

    2016-10-01

    In this paper, we investigate the band properties of 2D honeycomb plasmonic lattices consisting of metallic nanoparticles. By means of the coupled dipole method and quasi-static approximation, we theoretically analyze the band structures stemming from near-field interaction of localized surface plasmon polaritons for both the infinite lattice and ribbons. Naturally, the interaction of point dipoles decouples into independent out-of-plane and in-plane polarizations. For the out-of-plane modes, both the bulk spectrum and the range of the momentum k ∥ where edge states exist in ribbons are similar to the electronic bands in graphene. Nevertheless, the in-plane polarized modes show significant differences, which do not only possess additional non-flat edge states in ribbons, but also have different distributions of the flat edge states in reciprocal space. For in-plane polarized modes, we derived the bulk-edge correspondence, namely, the relation between the number of flat edge states at a fixed {k}\\parallel , Zak phases of the bulk bands and the winding number associated with the bulk Hamiltonian, and verified it through four typical ribbon boundaries, i.e. zigzag, bearded zigzag, armchair, and bearded armchair. Our approach gives a new topological understanding of edge states in such plasmonic systems, and may also apply to other 2D ‘vector wave’ systems.

  2. Topological collective plasmons in bipartite chains of metallic nanoparticles

    NASA Astrophysics Data System (ADS)

    Downing, Charles A.; Weick, Guillaume

    2017-03-01

    We study a bipartite linear chain constituted by spherical metallic nanoparticles, where each nanoparticle supports a localized surface plasmon. The near-field dipolar interaction between the localized surface plasmons gives rise to collective plasmons, which are extended over the whole nanoparticle array. We derive analytically the spectrum and the eigenstates of the collective plasmonic excitations. At the edge of the Brillouin zone, the spectrum is of a pseudorelativistic nature similar to that present in the electronic band structure of polyacetylene. We find the effective Dirac Hamiltonian for the collective plasmons and show that the corresponding spinor eigenstates represent one-dimensional Dirac-like massive bosonic excitations. Therefore, the plasmonic lattice exhibits similar effects to those found for electrons in one-dimensional Dirac materials, such as the ability for transmission with highly suppressed backscattering due to Klein tunneling. We also show that the system is governed by a nontrivial Zak phase, which predicts the manifestation of edge states in the chain. When two dimerized chains with different topological phases are connected, we find the appearance of the bosonic version of a Jackiw-Rebbi midgap state. We further investigate the radiative and nonradiative lifetimes of the collective plasmonic excitations and comment on the challenges for experimental realization of the topological effects found theoretically.

  3. Manipulating the one-dimensional topological edge state of Bi bilayer nanoribbons via magnetic orientation and electric field

    NASA Astrophysics Data System (ADS)

    Kim, Jeongwoo; Wu, Ruqian

    2018-03-01

    Despite the superiority of two-dimensional (2D) topological insulators (TIs) over their three-dimensional (3D) counterparts in various aspects and the essential distinction between them in structural symmetry, the variation of the topological one-dimensional (1D) edge states upon magnetic interaction and their application for spintronic devices have not been sufficiently illuminated. Here, we reveal that 1D edge states of 2D TIs have a unique magnetic response never observed in 2D surface states of 3D TIs, and using this exotic nature we propose a way to utilize the spin-polarized channel for spintronic applications. We investigate the effects of width and magnetic decoration on the 1D topological edge state of Bi bilayer nanoribbons (BNRs). Through the Zak phase, we find that the zero-energy states are enforced at the magnetic domain boundaries in the Cr-decorated BNR and directly examine their robustness using short-range magnetic domain structures. We also demonstrate that 1D edge states of BNRs can be selectively and reversibly controlled by the combination of magnetic reorientation and electric field without compromising their structural integrity. Our work provides a fundamental understanding of 1D topological edge states and shows the opportunity of using these features in spintronic devices.

  4. Topological nanophononic states by band inversion

    NASA Astrophysics Data System (ADS)

    Esmann, Martin; Lamberti, Fabrice Roland; Senellart, Pascale; Favero, Ivan; Krebs, Olivier; Lanco, Loïc; Gomez Carbonell, Carmen; Lemaître, Aristide; Lanzillotti-Kimura, Norberto Daniel

    2018-04-01

    Nanophononics is essential for the engineering of thermal transport in nanostructured electronic devices, it greatly facilitates the manipulation of mechanical resonators in the quantum regime, and it could unveil a new route in quantum communications using phonons as carriers of information. Acoustic phonons also constitute a versatile platform for the study of fundamental wave dynamics, including Bloch oscillations, Wannier-Stark ladders, and other localization phenomena. Many of the phenomena studied in nanophononics were inspired by their counterparts in optics and electronics. In these fields, the consideration of topological invariants to control wave dynamics has already had a great impact for the generation of robust confined states. Interestingly, the use of topological phases to engineer nanophononic devices remains an unexplored and promising field. Conversely, the use of acoustic phonons could constitute a rich platform to study topological states. Here, we introduce the concept of topological invariants to nanophononics and experimentally implement a nanophononic system supporting a robust topological interface state at 350 GHz. The state is constructed through band inversion, i.e., by concatenating two semiconductor superlattices with inverted spatial mode symmetries. The existence of this state is purely determined by the Zak phases of the constituent superlattices, i.e., the one-dimensional Berry phase. We experimentally evidenced the mode through Raman spectroscopy. The reported robust topological interface states could become part of nanophononic devices requiring resonant structures such as sensors or phonon lasers.

  5. PREFACE: XXXth International Colloquium on Group Theoretical Methods in Physics (ICGTMP) (Group30)

    NASA Astrophysics Data System (ADS)

    Brackx, Fred; De Schepper, Hennie; Van der Jeugt, Joris

    2015-04-01

    The XXXth International Colloquium on Group Theoretical Methods in Physics (ICGTMP), also known as the Group30 conference, took place in Ghent (Belgium) from Monday 14 to Friday 18 July 2014. The conference was organised by Ghent University (Department of Applied Mathematics, Computer Science and Statistics, and Department of Mathematical Analysis). The website http://www.group30.ugent.be is still available. The ICGTMP is one of the traditional conference series covering the most important topics of symmetry which are relevant to the interplay of present-day mathematics and physics. More than 40 years ago a group of enthusiasts, headed by H. Bacry of Marseille and A. Janner of Nijmegen, initiated a series of annual meetings with the aim to provide a common forum for scientists interested in group theoretical methods. At that time most of the participants belonged to two important communities: on the one hand solid state specialists, elementary particle theorists and phenomenologists, and on the other mathematicians eager to apply newly-discovered group and algebraic structures. The conference series has become a meeting point for scientists working at modelling physical phenomena through mathematical and numerical methods based on geometry and symmetry. It is considered as the oldest one among the conference series devoted to geometry and physics. It has been further broadened and diversified due to the successful applications of geometric and algebraic methods in life sciences and other areas. The first four meetings took place alternatively in Marseille and Nijmegen. Soon after, the conference acquired an international standing, especially following the 1975 colloquium in Nijmegen and the 1976 colloquium in Montreal. Since then it has been organized in many places around the world. It has become a bi-annual colloquium since 1990, the year it was organized in Moscow. This was the first time the colloquium took place in Belgium. There were 246 registered participants at the Group30 colloquium from 46 different countries. This high number of participants makes the 30th edition of ICGTMP one of the most successful meetings of the series. We were particularly happy with the attendance of 32 students and many young postdocs: this is promising for the future of the research field and of the colloquium series. The attraction of young scientists was promoted by a reduced participation fee, the availability of cheap accommodation in the University Student Guest House, grants from a US-NSF project and grants from the Organising Committee supporting participants from countries with limited financial resources. The colloquium brought together international top researchers, with a variety of different backgrounds but with "group theoretical or algebraic methods" as common ground. The selection of plenary speakers and topics was made by the Organizing Committee, following the suggestions of the International Advisory Committee (consisting of prominent scientists in their domain), and ensuring the diversity of the subjects treated. There were 11 plenary talks, given as well by distinguished world experts as by young rising stars: Matthias Christandl, Alberto De Sole, Rui Loja Fernandes, François Gay-Balmaz, Gitta Kutyniok, Amiram Leviatan, Karl-Hermann Neeb, Christoph Schweigert, Yuji Tachikawa, Luc Vinet and Joshua Zak. Next to the plenary talks, there were 170 talks in six parallel sessions and 10 poster presentations. All scientific activities took place in the Joseph Plateau Building of the Faculty of Engineering and Architecture of Ghent University, a historical building conveniently located in the city centre of Ghent. In this building we could make use of the main lecture hall (400 seats) for the plenary lectures, six lecture rooms for parallel sessions, two offices for organizational activities and registrations, two PC-rooms and a large foyer for coffee breaks, book exhibitions and the poster session. As part of the colloquium, a panel discussion on recent advances and future challenges in group theoretical methods in physics was held on Wednesday morning. The panel members were: Maia Angelova, Heinz-Dietrich Doebner, Jean-Pierre Gazeau, Norbert Hounkonnou, Peter Olver and Luc Vinet, with Willard Miller Jr. as moderator. In this discussion, the importance of "symmetry" in physics (and other sciences) was emphasized, and some challenges were made explicit. On Wednesday evening there was a separate ceremony in the Aula Academica (the "University Palace") of Ghent University, for the presentation of the 2014 Wigner Medal and Hermann Weyl Prize. The Hermann Weyl Prize was established in 2000 to provide recognition for young scientists having performed original work of significant scientific quality in the area of the understanding of physics through symmetries. The 2014 Hermann Weyl Prize was awarded to Yuji Tachikawa (Tokyo University). He is praised for his outstanding contributions to the understanding of supersymmetric quantum field theories and in particular, to the discovery of the Alday-Gaiotto-Tachikawa correspondence that has led to spectacular advances in both mathematics and quantum physics. The Wigner Medal, established in 1978, is an award designed "to recognize outstanding contributions to the understanding of physics through Group Theory", and can be considered as a "lifetime achievement award". It was awarded to Joshua Zak (Technion, Haifa, Israel) for his discovery of the magnetic translation group and the phase and transform that bear his name. In his work, the relationship between mathematics and physics could hardly be closer, with mathematicians being familiar with the "Zak transform" and physicists with the "Zak phase", both concepts originating in group theory. The ceremony was graced by a saxophone quintet, "Sax Obsession", and followed by a reception in the adjacent Peristylium. The social programme included a variety of events. On Monday evening, the welcome address by Christophe Peeters, Deputy Mayor of the City of Ghent, was followed by a reception in the historical "Pacificatiezaal" of the City Hall. On Wednesday afternoon the participants had the opportunity to take a guided tour through medieval Ghent, admiring its wide range of monuments. The tour was followed by a much-appreciated boat trip exploring the canals and rivers of Ghent, all in sunny weather. On Thursday evening the conference banquet was held in the "Brasserie HA". Located in the Handelsbeurs Ghent. In the majestic banquet hall, the participants were not only treated to an exclusive dinner, but also to some fine piano music by Dmitry Gal'tsov and Richard Kerner. The conference was sponsored by: American Institute of Physics (AIP Publishing), Clay Mathematics Institute, Clifford Research Group - Faculty of Engineering and Architecture (Ghent Unviversity), Elsevier, Faculty of Sciences (Ghent University), Fonds de la Recherche Scientifique (FNRS), Foundation Compositio Mathematica, FWO Research Foundation - Flanders, International Association of Mathematical Physics, International Solvay Institutes, International Union of Pure and Applied Physics, National Science Foundation (USA) and Springer Birkhäuser. We would like to thank all our sponsors for their generous support. It took more than two years to organise a conference of such a size and importance. We express our gratitude to the International Advisory Committee for its help in selecting the plenary speakers and to the external members of the Organising Committee for their helpful suggestions and advice. We thank Wouter Dewolf for his devoted secretarial, administrative and organisational work and Vera Vanden Driessche for arranging the "Accompanying persons' programme". Finally, a big 'thank you' to all the local people (administrative and technical staff, research assistants and research students) for their devoted and tireless work in preparing and running the conference. Fred Brackx, Hennie De Schepper and Joris Van der Jeugt

  6. The Treatment of Restless Legs Syndrome and Periodic Limb Movement Disorder in Adults—An Update for 2012: Practice Parameters with an Evidence-Based Systematic Review and Meta-Analyses

    PubMed Central

    Aurora, R. Nisha; Kristo, David A.; Bista, Sabin R.; Rowley, James A.; Zak, Rochelle S.; Casey, Kenneth R.; Lamm, Carin I.; Tracy, Sharon L.; Rosenberg, Richard S.

    2012-01-01

    A systematic literature review and meta-analyses (where appropriate) were performed to update the previous AASM practice parameters on the treatments, both dopaminergic and other, of RLS and PLMD. A considerable amount of literature has been published since these previous reviews were performed, necessitating an update of the corresponding practice parameters. Therapies with a STANDARD level of recommendation include pramipexole and ropinirole. Therapies with a GUIDELINE level of recommendation include levodopa with dopa decarboxylase inhibitor, opioids, gabapentin enacarbil, and cabergoline (which has additional caveats for use). Therapies with an OPTION level of recommendation include carbamazepine, gabapentin, pregabalin, clonidine, and for patients with low ferritin levels, iron supplementation. The committee recommends a STANDARD AGAINST the use of pergolide because of the risks of heart valve damage. Therapies for RLS secondary to ESRD, neuropathy, and superficial venous insufficiency are discussed. Lastly, therapies for PLMD are reviewed. However, it should be mentioned that because PLMD therapy typically mimics RLS therapy, the primary focus of this review is therapy for idiopathic RLS. Citation: Aurora RN; Kristo DA; Bista SR; Rowley JA: Zak RS; Casey KR; Lamm CI; Tracy SL; Rosenberg RS. The treatment of restless legs syndrome and periodic limb movement disorder in adults—an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses. SLEEP 2012;35(8):1039-1062. PMID:22851801

  7. Building blocks of topological quantum chemistry: Elementary band representations

    NASA Astrophysics Data System (ADS)

    Cano, Jennifer; Bradlyn, Barry; Wang, Zhijun; Elcoro, L.; Vergniory, M. G.; Felser, C.; Aroyo, M. I.; Bernevig, B. Andrei

    2018-01-01

    The link between chemical orbitals described by local degrees of freedom and band theory, which is defined in momentum space, was proposed by Zak several decades ago for spinless systems with and without time reversal in his theory of "elementary" band representations. In a recent paper [Bradlyn et al., Nature (London) 547, 298 (2017), 10.1038/nature23268] we introduced the generalization of this theory to the experimentally relevant situation of spin-orbit coupled systems with time-reversal symmetry and proved that all bands that do not transform as band representations are topological. Here we give the full details of this construction. We prove that elementary band representations are either connected as bands in the Brillouin zone and are described by localized Wannier orbitals respecting the symmetries of the lattice (including time reversal when applicable), or, if disconnected, describe topological insulators. We then show how to generate a band representation from a particular Wyckoff position and determine which Wyckoff positions generate elementary band representations for all space groups. This theory applies to spinful and spinless systems, in all dimensions, with and without time reversal. We introduce a homotopic notion of equivalence and show that it results in a finer classification of topological phases than approaches based only on the symmetry of wave functions at special points in the Brillouin zone. Utilizing a mapping of the band connectivity into a graph theory problem, we show in companion papers which Wyckoff positions can generate disconnected elementary band representations, furnishing a natural avenue for a systematic materials search.

  8. Best Practice Guide for the Treatment of Nightmare Disorder in Adults

    PubMed Central

    Aurora, R. Nisha; Zak, Rochelle S.; Auerbach, Sanford H.; Casey, Kenneth R.; Chowdhuri, Susmita; Karippot, Anoop; Maganti, Rama K.; Ramar, Kannan; Kristo, David A.; Bista, Sabin R.; Lamm, Carin I.; Morgenthaler, Timothy I.

    2010-01-01

    Summary of Recommendations: Prazosin is recommended for treatment of Posttraumatic Stress Disorder (PTSD)-associated nightmares. Level A Image Rehearsal Therapy (IRT) is recommended for treatment of nightmare disorder. Level A Systematic Desensitization and Progressive Deep Muscle Relaxation training are suggested for treatment of idiopathic nightmares. Level B Venlafaxine is not suggested for treatment of PTSD-associated nightmares. Level B Clonidine may be considered for treatment of PTSD-associated nightmares. Level C The following medications may be considered for treatment of PTSD-associated nightmares, but the data are low grade and sparse: trazodone, atypical antipsychotic medications, topiramate, low dose cortisol, fluvoxamine, triazolam and nitrazepam, phenelzine, gabapentin, cyproheptadine, and tricyclic antidepressants. Nefazodone is not recommended as first line therapy for nightmare disorder because of the increased risk of hepatotoxicity. Level C The following behavioral therapies may be considered for treatment of PTSD-associated nightmares based on low-grade evidence: Exposure, Relaxation, and Rescripting Therapy (ERRT); Sleep Dynamic Therapy; Hypnosis; Eye-Movement Desensitization and Reprocessing (EMDR); and the Testimony Method. Level C The following behavioral therapies may be considered for treatment of nightmare disorder based on low-grade evidence: Lucid Dreaming Therapy and Self-Exposure Therapy. Level C No recommendation is made regarding clonazepam and individual psychotherapy because of sparse data. Citation: Aurora RN; Zak RS; Auerbach SH; Casey KR; Chowduri S; Krippot A; Maganti RK; Ramar K; Kristo DA; Bista SR; Lamm CI; Morgenthaler TI. Best practice guide for the treatment of nightmare disorder in adults. J Clin Sleep Med 2010;6(4):389-401. PMID:20726290

  9. a New Generation Mining Head with Disc Tool of Complex Trajectory / GŁOWICA URABIAJĄCA Nowej Generacji Z NARZĘDZIAMI Dyskowymi O ZŁOŻONEJ Trajektorii

    NASA Astrophysics Data System (ADS)

    Gospodarczyk, Piotr; Kotwica, Krzysztof; Stopka, Grzegorz

    2013-12-01

    In Polish underground mining plenty of dog headings are drilled with mechanical methods with the use of arm roadheaders equipped with milling units. Cutting tools applied on the units - rotary tangent bits in unfavourable mining and geological conditions or improper work conditions are affected by an accelerated wear process. It influences the speed and costs of drilling such excavations. The article presents a new and innovative solution of a mining head with asymmetric disc tools of complex trajectory elaborated at the Department of Mining, Dressing and Transport Machines, AGH University of Science and Technology, Krakow as an alternative for standard milling units. Advantages of the applied mining method using so called back incision were described as well as principles of construction and work of the suggested solution of the head. In order to work out a construction of the head prototype it was necessary to determine principles and guidelines based on laboratory tests. A construction of a specially prepared laboratory stand for examination of disc tools of complex trajectory, planned research methodology, course of tests and obtained results were presented. An analysis of the results allowed determining the above listed principles and guidelines for a construction of a prototype head. They were the base to work out, with cooperation of the REMAG Ltd Company in Katowice, a technical project of a new head solution, adapted for mounting on the arm of a medium arm roadheader KR 150. A constructed head underwent tests on a research stand on the REMAG testing area and received positive preliminary tests results. W polskim górnictwie podziemnym bardzo duża liczba wyrobisk korytarzowych drążona jest metodami mechanicznymi z wykorzystaniem ramionowych kombajnów chodnikowych, wyposażonych w organy frezujące. Stosowane na tych organach narzędzia skrawające - noże styczno-obrotowe, w niekorzystnych warunkach górniczo-geologicznych lub przy nieprawidłowych warunkach pracy, ulegają przyspieszonemu zużyciu. Wpływa to na prędkość i koszty drążenia tych wyrobisk. W artykule przedstawiono opracowane w Katedrze MGPiT AGH Kraków nowe i innowacyjne rozwiązanie głowicy urabiającej, z narzędziami dyskowymi niesymetrycznymi o złożonej trajektorii, jako alternatywę dla standardowych organów frezujących. Opisano zalety zastosowanej metody urabiania z wykorzystaniem tzw. tylnego podcinaniaoraz zasadę budowy i pracy zaproponowanego rozwiązania przedmiotowej głowicy. Dla opracowania konstrukcji prototypowego egzemplarza tej głowicy koniecznym było określenie, na podstawie badań laboratoryjnych, założeń i wytycznych. Przedstawiono konstrukcję opracowanego specjalnego stanowiska laboratoryjnego do badania narzędzi dyskowych o złożonej trajektorii, założoną metodykę badawczą, przebieg badań oraz uzyskane wyniki. Analiza tych wyników umożliwiła określenie wyżej wymienionych założeń i wytycznych dla konstrukcji głowicy prototypowej. Na ich podstawie opracowano, we współpracy z Zakładami REMAG S.A. w Katowicach, projekt techniczny nowego rozwiązania głowicy, dostosowanej do zabudowy na ramieniu średniego kombajnu chodnikowego KR 150. Wykonany egzemplarz głowicy został poddany próbom na stanowisku badawczym na poligonie Zakładów REMAG i uzyskał pozytywne wyniki badań wstępnych.

  10. Best Practice Guide for the Treatment of REM Sleep Behavior Disorder (RBD)

    PubMed Central

    Aurora, R. Nisha; Zak, Rochelle S.; Maganti, Rama K.; Auerbach, Sanford H.; Casey, Kenneth R.; Chowdhuri, Susmita; Karippot, Anoop; Ramar, Kannan; Kristo, David A.; Morgenthaler, Timothy I.

    2010-01-01

    Summary of Recommendations: Modifying the sleep environment is recommended for the treatment of patients with RBD who have sleep-related injury. Level A Clonazepam is suggested for the treatment of RBD but should be used with caution in patients with dementia, gait disorders, or concomitant OSA. Its use should be monitored carefully over time as RBD appears to be a precursor to neurodegenerative disorders with dementia in some patients. Level B Clonazepam is suggested to decrease the occurrence of sleep-related injury caused by RBD in patients for whom pharmacologic therapy is deemed necessary. It should be used in caution in patients with dementia, gait disorders, or concomitant OSA, and its use should be monitored carefully over time. Level B Melatonin is suggested for the treatment of RBD with the advantage that there are few side effects. Level B Pramipexole may be considered to treat RBD, but efficacy studies have shown contradictory results. There is little evidence to support the use of paroxetine or L-DOPA to treat RBD, and some studies have suggested that these drugs may actually induce or exacerbate RBD. There are limited data regarding the efficacy of acetylcholinesterase inhibitors, but they may be considered to treat RBD in patients with a concomitant synucleinopathy. Level C The following medications may be considered for treatment of RBD, but evidence is very limited with only a few subjects having been studied for each medication: zopiclone, benzodiazepines other than clonazepam, Yi-Gan San, desipramine, clozapine, carbamazepine, and sodium oxybate. Level C Citation: Aurora RN; Zak RS; Maganti RK; Auerbach SH; Casey KR; Chowdhuri S; Karippot A; Ramar K; Kristo DA; Morgenthaler TI. Best practice guide for the treatment of REM sleep behavior disorder (RBD). J Clin Sleep Med 2010;6(1):85-95. PMID:20191945

  11. Practice Parameters for the Treatment of Narcolepsy and other Hypersomnias of Central Origin An American Academy of Sleep Medicine Report

    PubMed Central

    Morgenthaler, Timothy I.; Kapur, Vishesh K.; Brown, Terry; Swick, Todd J.; Alessi, Cathy; Aurora, R. Nisha; Boehlecke, Brian; Chesson, Andrew L.; Friedman, Leah; Maganti, Rama; Owens, Judith; Pancer, Jeffrey; Zak, Rochelle

    2007-01-01

    These practice parameters pertain to the treatment of hypersomnias of central origin. They serve as both an update of previous practice parameters for the therapy of narcolepsy and as the first practice parameters to address treatment of other hypersomnias of central origin. They are based on evidence analyzed in the accompanying review paper. The specific disorders addressed by these parameters are narcolepsy (with cataplexy, without cataplexy, due to medical condition and unspecified), idiopathic hypersomnia (with long sleep time and without long sleep time), recurrent hypersomnia and hypersomnia due to medical condition. Successful treatment of hypersomnia of central origin requires an accurate diagnosis, individual tailoring of therapy to produce the fullest possible return of normal function, and regular follow-up to monitor response to treatment. Modafinil, sodium oxybate, amphetamine, methamphetamine, dextroamphetamine, methylphenidate, and selegiline are effective treatments for excessive sleepiness associated with narcolepsy, while tricyclic antidepressants and fluoxetine are effective treatments for cataplexy, sleep paralysis, and hypnagogic hallucinations; but the quality of published clinical evidence supporting them varies. Scheduled naps can be beneficial to combat sleepiness in narcolepsy patients. Based on available evidence, modafinil is an effective therapy for sleepiness due to idiopathic hypersomnia, Parkinson's disease, myotonic dystrophy, and multiple sclerosis. Based on evidence and/or long history of use in the therapy of narcolepsy committee consensus was that modafinil, amphetamine, methamphetamine, dextroamphetamine, and methylphenidate are reasonable options for the therapy of hypersomnias of central origin. Citation: Morgenthaler TI; Kapur VK; Brown T; Swick TJ; Alessi C; Aurora RN; Boehlecke B; Chesson AL; Friedman L; Maganti R; Owens J; Pancer J; Zak R; Standards of Practice Committee of the AASM. Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin. SLEEP 2007;30(12):1705-1711. PMID:18246980

  12. Rapid-Adiabatic Control of Ro-Vibrational Populations in Polyatomic Molecules

    NASA Astrophysics Data System (ADS)

    Zak, Emil J.; Yachmenev, Andrey

    2017-06-01

    We present a simple method for control of ro-vibrational populations in polyatomic molecules in the presence of inhomogeneous electric fields [1]. Cooling and trapping of heavy polar polyatomic molecules has become one of the frontier goals in high-resolution molecular spectroscopy, especially in the context of parity violation measurement in chiral compounds [2]. A key step toward reaching this goal would be development of a robust and efficient protocol for control of populations of ro-vibrational states in polyatomic, often floppy molecules. Here we demonstrate a modification of the stark-chirped rapid-adiabatic-passage technique (SCRAP) [3], designed for achieving high levels of control of ro-vibrational populations over a selected region in space. The new method employs inhomogeneous electric fields to generate space- and time- controlled Stark-shifts of energy levels in molecules. Adiabatic passage between ro-vibrational states is enabled by the pump pulse, which raises the value of the Rabi frequency. This Stark-chirped population transfer can be used in manipulation of population differences between high-field-seeking and low-field-seeking states of molecules in the Stark decelerator [4]. Appropriate timing of voltages on electric rods located along the decelerator combined with a single pump laser renders our method as potentially more efficient than traditional Stark decelerator techniques. Simulations for NH_3 show significant improvement in effectiveness of cooling, with respect to the standard 'moving-potential' method [5]. At the same time a high phase-space acceptance of the molecular packet is maintained. E. J. Zak, A. Yachmenev (submitted). C. Medcraft, R. Wolf, M. Schnell, Angew. Chem. Int. Ed., 53, 43, 11656-11659 (2014) M. Oberst, H. Munch, T. Halfman, PRL 99, 173001 (2007). K. Wohlfart, F. Grätz, F. Filsinger, H. Haak, G. Meijer, J. Küpper, Phys. Rev. A 77, 031404(R) (2008). H. L. Bethlem, F. M. H. Crompvoets, R. T. Jongma, S. Y. T. van de Meerakker, G. Meijer, Phys. Rev. A, 65, 053416 (2002).

  13. Physiological strain in the Hungarian mining industry: The impact of physical and psychological factors.

    PubMed

    Varga, József; Nagy, Imre; Szirtes, László; Pórszász, János

    2016-01-01

    The objectives of these investigations completed on workplaces in the Hungarian mining industry were to characterize the physiological strain of workers by means of work pulse and to examine the effects of work-related psychological factors. Continuous heart rate (HR) recording was completed on 71 miners over a total of 794 shifts between 1987 and 1992 in mining plants of the Hungarian mining industry using a 6-channel recorder - Bioport (ZAK, Germany). The work processes were simultaneously documented by video recording along with drawing up the traditional ergonomic workday schedule. All workers passed health evaluation for fitness for work. The effects of different psychological factors (simulated danger, "instrument stress," presence of managers, and effect of prior involvement in accidents as well as different mining technologies and work place illumination) on the work pulse were evaluated. The statistical analysis was completed using SPSS software (version 13.0, SPSS Inc., USA). The work-related physiological strain differed between work places with different mining technologies in groups of 12-18 workers. The work pulse was lowest in bauxite mining (ΔHR = 22±8.9 bpm) and highest in drift drilling in dead rock with electric drilling machine (ΔHR = 30±6.9 bpm). During sham alarm situation the work pulse was significantly higher than during normal activities with the same physical task (ΔHR = 36.7±4.8 bpm vs. 25.8±1.6 bpm, p < 0.001). When work was performed under different psychological stress, the work pulse was consistently higher, while improving the work place illumination decreased the physiological strain appreciably (ΔHR (median, 25-75 percentiles) = 23, 20-26 bmp vs. 28, 25-31.3 bpm, p < 0.001). Recording the heart rate during whole-shift work along with the work conditions gives reliable results and helps isolating factors that contribute to increased strain. The results can be used to implement preventive and health promotion measures. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

  14. Regional model studies of the atmospheric dispersion of fine volcanic ash after the eruption of Eyjafjallajoekull

    NASA Astrophysics Data System (ADS)

    Langmann, B.; Hort, M. K.

    2010-12-01

    During the eruption of Eyjafjallajoekull on Iceland in April/May 2010 air traffic over Europe was repeatedly interrupted because of volcanic ash in the atmosphere. This completely unusual situation in Europe leads to the demand of improved crisis management, e.g. European wide regulations of volcanic ash thresholds and improved forecasts of theses thresholds. However, the quality of the forecast of fine volcanic ash concentrations in the atmosphere depends to a great extent on a realistic description of the erupted mass flux of fine ash particles, which is rather uncertain. Numerous aerosol measurements (ground based and satellite remote sensing, and in situ measurements) all over Europe have tracked the volcanic ash clouds during the eruption of Eyjafjallajoekull offering the possibility for an interdisciplinary effort between volcanologists and aerosol researchers to analyse the release and dispersion of fine volcanic ash in order to better understand the needs for realistic volcanic ash forecasts. This contribution describes the uncertainties related to the amount of fine volcanic ash released from Eyjafjallajoekull and its influence on the dispersion of volcanic ash over Europe by numerical modeling. We use the three-dimensional Eulerian atmosphere-chemistry/aerosol model REMOTE (Langmann et al., 2008) to simulate the distribution of volcanic ash as well as its deposition after the eruptions of Eyjafjallajoekull during April and May 2010. The model has been used before to simulate the fate of the volcanic ash after the volcanic eruptions of Kasatochi in 2008 (Langmann et al., 2010) and Mt. Pinatubo in 1991. Comparing our model results with available measurements for the Eyjafjallajoekull eruption we find a quite good agreement with available ash concentrations data measured over Europe as well as with the results from other models. Langmann, B., K. Zakšek and M. Hort, Atmospheric distribution and removal of volcanic ash after the eruption of Kasatochi volcano: A regional model study, J. Geophys. Res., 115, D00L06, doi:10.1029/2009JD013298, 2010. Langmann, B., S. Varghese, E. Marmer, E. Vignati, J. Wilson, P. Stier and C. O’Dowd, Aerosol distribution over Europe: A model evaluation study with detailed aerosol microphysics, Atmos. Chem. Phys. 8, 1591-1607, 2008.

  15. Cytokine Polymorphisms are Associated with Poor Sleep Maintenance in Adults Living with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome

    PubMed Central

    Lee, Kathryn A.; Gay, Caryl; Pullinger, Clive R.; Hennessy, Mary Dawn; Zak, Rochelle S.; Aouizerat, Bradley E.

    2014-01-01

    Study Objectives: Cytokine activity and polymorphisms have been associated with sleep outcomes in prior animal and human research. The purpose of this study was to determine whether circulating plasma cytokines and cytokine polymorphisms are associated with the poor sleep maintenance commonly experienced by adults living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). Design: Cross-sectional descriptive study. Setting: HIV clinics and community sites in the San Francisco Bay area. Participants: A convenience sample of 289 adults (193 men, 73 women, and 23 transgender) living with HIV/AIDS. Interventions: None. Measurements and Results: A wrist actigraph was worn for 72 h to estimate the percentage of wake after sleep onset (WASO%) and total sleep time (TST), plasma cytokines were analyzed, and genotyping was conducted for 15 candidate genes involved in cytokine signaling: interferon-gamma (IFNG), IFNG receptor 1 (IFNGR1), interleukins (IL1B, IL1R2, IL1R2, IL2, IL4, IL6, IL8, IL10, IL13, IL17A), nuclear factor of kappa light polypeptide gene enhancer in B cells (NFKB1 and NFKB2), and tumor necrosis factor-alpha (TNFA). Controlling for demographic variables such as race and sex, and clinical variables such as CD4+ count and medications, higher WASO% was associated with single nucleotide polymorphisms (SNPs) of IL1R2 rs11674595 and TNFA rs1041981 and less WASO% was associated with IL2 rs2069776. IL1R2 rs11674595 and TNFA rs1041981 were also associated with short sleep duration. Conclusions: This study strengthens the evidence for an association between inflammation and sleep maintenance problems. In this chronic illness population, cytokine polymorphisms associated with wake after sleep onset provide direction for intervention research aimed at comparing anti-inflammatory mechanisms with hypnotic agents for improving sleep maintenance and total sleep time. Citation: Lee KA; Gay C; Pullinger CR; Hennessy MD; Zak RS; Aouizerat BE. Cytokine polymorphisms are associated with poor sleep maintenance in adults living with human immunodeficiency virus/acquired immunodeficiency syndrome. SLEEP 2014;37(3):453-463. PMID:24587567

  16. Simulation-Assisted Evaluation of Grinding Circuit Flowsheet Design Alternatives: Aghdarreh Gold Ore Processing Plant / Ocena Alternatywnych Schematów Technologicznych Procesu Rozdrabniania W Zakładach Przeróbki Rud Złota W Aghdarreh, Z Wykorzystaniem Metod Symulacji

    NASA Astrophysics Data System (ADS)

    Farzanegan, A.; Ghalaei, A. Ebtedaei

    2015-03-01

    The run of mine ore from Aghdarreh gold mine must be comminuted to achieve the desired degree of liberation of gold particles. Currently, comminution circuits include a single-stage crushing using a jaw crusher and a single-stage grinding using a Semi-Autogenous Grinding (SAG) mill in closed circuit with a hydrocyclone package. The gold extraction is done by leaching process using cyanidation method through a series of stirred tanks. In this research, an optimization study of Aghdarreh plant grinding circuit performance was done to lower the product particle size (P80) from 70 μm to approximately 40 μm by maintaining current throughput using modeling and simulation approach. After two sampling campaigns from grinding circuit, particle size distribution data were balanced using NorBal software. The first and second data sets obtained from the two sampling campaigns were used to calibrate necessary models and validate them prior to performing simulation trials using MODSIM software. Computer simulations were performed to assess performance of two proposed new circuit flowsheets. The first proposed flowsheet consists of existing SAG mill circuit and a new proposed ball mill in closed circuit with a new second hydrocyclone package. The second proposed flowsheet consists of existing SAG mill circuit followed by a new proposed ball mill in closed circuit with the existing hydrocyclone package. In all simulations, SAGT, CYCL and MILL models were selected to simulate SAG mill, Hydrocyclone packages and ball mill units. SAGT and MILL models both are based on population balance model of grinding process. CYCL model is based on Plitt's empirical model of classification process in hydrocyclone units. It was shown that P80 can be reduced to about 40 μm and 42 μm for the first and second proposed circuits, respectively. Based on capital and operational costs, it can be concluded that the second proposed circuit is a more suitable option for plant grinding flowsheet modification. Surowy urobek z kopalni rud złota Aghdarreh musi najpierw zostać poddany rozdrobnieniu, aby zapewnić efektywniejsze uwalnianie cząsteczek złota. W chwili obecnej obiegi rozdrabniania obejmują kruszenie jednostopniowe z wykorzystaniem kruszarek szczękowych oraz kruszenie jednostopniowe z użyciem kruszarek półautomatycznych w obiegu zamkniętym z hydrocyklonem. Odzysk złota odbywa się przy zastosowaniu procesu ługowania, z zastosowaniem metody cyjankowej w szeregu mieszalników. W pracy tej przeprowadzono optymalizację procesu rozdrabniania rud w zakładach przeróbczych Aghdarreh prowadzonego w celu zmniejszenia rozmiarów uzyskiwanych cząsteczek złota (Ps0) z 70 μm do ok. 40 μm poprzez zapewnienie ciągłości procesu, z wykorzystaniem metod modelowania i symulacji. Na podstawie dwóch zestawów próbek z ciągu technologicznego rozdrabniania, rozkłady wielkości cząstek zostały statystycznie zrównoważone z wykorzystaniem oprogramowania NorBal. Pierwszy i drugi zbiór danych otrzymanych na podstawie dwóch zestawów próbek wykorzystany został do kalibracji i walidacji modeli, przed przystąpieniem do właściwych badań symulacyjnych z użyciem oprogramowania MODSIM. Symulacje komputerowe przeprowadzono w celu oceny wydajności dwóch proponowanych ciągów technologicznych. Pierwszy ciąg obejmuje istniejące kruszarki półautomatyczne i nowo proponowaną kruszarkę kulową pracującą w obiegu zamkniętym z hydrocyklonem. Drugi rozważany ciąg stanowi istniejąca kruszarka półautomatyczna, następnie proponowana kruszarka kulowa pracująca w obiegu zamkniętym z istniejącym hydrocyklonem. We wszystkich symulacjach bazowano na modelach SAGT, CYCL i MILL do symulacji pracy kruszarek półautomatycznych, pakietu hydrocyklonu oraz pojedynczych kruszarek. Modele SAGT i MILL oparte są na modelu zrównoważonej populacji w procesie rozdrabniania. Model CYCL opiera się na empirycznym modelu klasyfikacji Plitta zastosowanym do hydrocyklonów. Wykazano, że rozmiar cząstek zmniejszony został odpowiednio do 40 μm i 42 μm dla pierwszego i drugiego analizowanego obiegu. Uwzględniając nakłady kapitałowe oraz koszty operacyjne, wyciągnąć można więc wniosek, ze drugi proponowany układ jest korzystniejszą opcją modyfikacji istniejącego ciągu technologicznego rozdrabniania.

  17. Social costs of loss in productivity-related absenteeism in Poland.

    PubMed

    Genowska, Agnieszka; Fryc, Justyna; Pinkas, Jarosław; Jamiołkowski, Jacek; Szafraniec, Krystyna; Szpak, Andrzej; Bojar, Iwona

    2017-10-06

    The aim of this study was to estimate indirect costs associated with losses in productivity due to sickness absence among registered workers in Poland. Data on sick leave durations in 2013 was obtained from the Social Insurance Institution (SII) (Zakład Ubezpieczeń Społecznych - ZUS). Based on the number of assumptions, this data was used for calculating absence durations. The costs of lost productivity were estimated on the basis of the measure of gross value added. Estimated losses in productivity due to absenteeism in 2013 together accounted for 4.33% of gross domestic product (GDP) (17.09 billion euro). In the female population, the total value of losses amounted to 9.66 billion euro, but excluding the costs of pregnancy, childbirth, and puerperium (2.96 billion euro), it was 6.7 billion euro. In the male population, the loss amounted to 7.43 billion euro. The highest overall costs of sickness absence based on age were found in the age group of 30-39 years (5.14 billion euro, including pregnancy, childbirth, and puerperium - 1.474 billion euro; respiratory diseases - 0.632 billion euro, injuries and poisonings - 0.62 billion euro). In the group of people aged > 40 years, the highest cost was generated by bone-muscular diseases (1.553 billion euro) and injuries and poisoning (1.251 billion euro). Higher losses in the productivity of women in addition to pregnancy, childbirth, and puerperium were due to mental and behavioral disorders (0.71 billion euro), diseases of the genitourinary system (0.38 billion euro), and neoplasms (0.35 billion euro). At the same time, in men, compared to women, we observed higher losses due to injuries and poisoning (1.65 billion euro), and diseases of musculoskeletal (1.26 billion euro), nervous (0.79 billion euro), circulatory (0.65 billion euro), and digestive (0.41 billion euro) systems. Improvement and further development of effective strategies for prevention of complications of pregnancy and chronic diseases in the workplace are necessary. Policies aimed at reduction of sickness absence could potentially increase prosperity and the socioeconomic situation in Poland. Int J Occup Med Environ Health 2017;30(6):917-932. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

  18. Use of Cad Systems in Testing the Collision of Underground Transportation Means / Zastosowanie systemów Cad w badaniach kolizyjności środków transportu podziemnego

    NASA Astrophysics Data System (ADS)

    Dudek, Marek

    2013-06-01

    A concept of use of CAD systems in testing collision of underground transportation means is presented. Reasons for undertaking this problem are given with end users identified. The concept of the system for collision analyses of transported loads is described. Examples of collision analysis during transportation of powered roof support are given. Presented system is designed to aid planning, organizational and training activities undertaken in management of transportation safety in mines. It will be also possible to use software resources, developed within the system as the didactic material as regards safe transportation process, which include hazards to the employees working in the area of transportation operations. Developed prototype of a system for testing the collision of underground transportation means was positively assessed by employees of the Coal Company, JSC - industrial partner of KOMAG. This prototype is continuously improved and adapted for commercial implementation in the selected coal mines. W pracy przedstawiono koncepcję zastosowania systemów CAD w badaniach kolizyjności środków transportu podziemnego. Określono przyczyny podjęcia tematu oraz zidentyfikowano końcowych użytkowników. Zaprezentowano koncepcję systemu do analiz kolizyjności transportowanych ładunków. Pokazano przykłady analizy kolizyjności podczas transportu sekcji obudowy zmechanizowanej. Przedstawiony system przeznaczony jest do wspomagania działań planistycznych, organizacyjnych i szkoleniowych podejmowanych w zarządzaniu bezpieczeństwem transportu w zakładach górniczych. Opracowane w ramach systemu zasoby programowe będzie można również wykorzystać jako materiał dydaktyczny z zakresu bezpieczeństwa pracy w transporcie, uwzględniający zagrożenia dla pracowników pracujących w bezpośredniej strefie prac transportowych. Opracowany prototyp systemu do badania kolizyjności środków transportu podziemnego został pozytywnie oceniony przez pracowników Kompanii Węglowej S.A. - partnera przemysłowego KOMAG-u. Prototyp ten jest w chwili obecnej ciągle udoskonalany oraz przygotowywany do komercyjnego wdrożenia w wybranych kopalniach węgla kamiennego.

  19. Induction of gamma delta T cells using zoledronate plus interleukin-2 in patients with metastatic cancer.

    PubMed

    Nagamine, Ichiro; Yamaguchi, Yoshiyuki; Ohara, Masahiro; Ikeda, Takuhiro; Okada, Morihito

    2009-03-01

    A loss of human leukocyte antigen (HLA) expression in clinical tumors is one of their escape mechanisms from immune attack by HLA-restricted effector cells. In this study, the induction of HLA-unrestricted effector cells, gamma delta T cells, using zoledronate (ZOL) and interleukin (IL)-2 in vitro was investigated in patients with metastatic cancer. Peripheral blood mononuclear cells (PBMCs) from 10 cancer patients (8 colorectal and 2 esophageal) with multiple metastases and ascites lymphocytes from 3 cancer patients (1 gastric and 2 colorectal) were stimulated with varied concentrations of ZOL plus 100 U/ml IL-2 for 48 hr followed by culturing with IL-2 alone for 12 days. Lymphocyte proliferative responses were determined using 3H-TdR uptakes and interferon (IFN)-gamma production was evaluated using enzyme-linked immunosorbent assay. Surface phenotyping was performed using flow cytometry. Cytotoxic activity of effector cells was determined using 51Cr-releasing assay. It was found that proliferative responses of PBMCs were significantly stimulated with ZOL plus IL-2 when compared with IL-2 alone, showing 200 to 500-fold expansions for 2 weeks, although ZOL alone induced no response. The optimal concentration of ZOL was 1-5 microM. Ascites lymphocytes could also be stimulated with ZOL plus IL-2. The proliferative responses were remarkable in patients whose PBMCs could produce high levels of IFN-gamma during an initial 48-hr stimulation using ZOL plus IL-2. Removal of an adherent cell fraction before the induction augmented the proliferative responses in patients who otherwise had low-grade proliferative responses. Generated cells comprising approximately 90 or 20% in PBMCs from healthy donors or cancer patients, respectively, expressed gamma delta-type T-cell receptor. Gamma delta T cells showed high cytotoxic activity against CD166-positive TE12 and TE13 cancer cells but not against CD166-negative MKN45 cells. The cytotoxic activity against TE13 cells was augmented when target cells were pre-treated overnight with ZOL. These results suggest that ZOL in the presence of IL-2 can efficiently stimulate the proliferation of gamma delta T cells, which have cytotoxic properties against cancer cells. The use of zoledronate-activated killer (ZAK) cells should be encouraged in possible adoptive immunotherapy trials for patients with incurable cancer.

  20. Results of the Promethee Method Application in Selecting the Technological System at the Majdan III Open Pit Mine / Wyniki Zastosowania Metody Promethee do Wyboru Systemu Technologicznego W Kopalni Odkrywkowej Majdan III

    NASA Astrophysics Data System (ADS)

    Vujić, Slobodan; Hudej, Marjan; Miljanović, Igor

    2013-12-01

    This paper discusses the application of the PROMETHEE model and the results achieved in practice, following the example of the multi-criteria selection of the technological system at the Majdan III clay mineral raw material open pit mine of the Potisje Company, Republic of Serbia. After the introduction comments, reasons are explained for selecting the new technological system, conditions and limitations for the seven alternative solutions considered are described, mathematical foundation for the PROMETHEE method and a multi-criteria model of the problem in question are presented. The solution with the following structure was ranked first and accepted by the Company management as the best: Bucket chain excavator - Conveyor belts - Spreader (ECS), alongside a decision is made on the acquisition of machinery and system construction. The system was put into operation in 2000. The experience and the data accumulated in the previous twelve years confirm that the decision made on the application of the ECS technology was just, and the conclusion lists the benefits achieved. W artykule omówiono zastosowanie modelu Promethee i przedyskutowano uzyskane w ten sposób wyniki na przykładzie wielokryterialnego wyboru systemu technologicznego do zastosowania w kopalni odkrywkowej minerałów ilastych Majdan III, należącej do przedsiębiorstwa górniczego Potisje (Republika Serbii). Po uwagach wprowadzających przedstawiono powody wyboru nowego ciągu technologicznego, omówiono warunki oraz ograniczenia dla siedmiu alternatywnych rozwiązań, podstawy matematyczne metody Promethee oraz wielokryterialny model zagadnienia. Rozwiązanie uznane za najlepsze i zaaprobowane przez zarząd przedsiębiorstwa zakłada zastosowanie następującego ciągu technologicznego: koparka łancuchowa jednonaczyniowa - przenośniki taśmowe - rozkładarka(system ECS). Podjęto także decyzje odnośnie zakupu sprzętu i instalacji systemu, który uruchomiony został w 2000 roku. Doświadczenia i danezebrane z przeciągu ostatnich dwunastu lat potwierdzają zasadność wyboru systemu technologicznego. W podsumowaniu zestawiono listę uzyskanych korzyści

  1. The Treatment of Central Sleep Apnea Syndromes in Adults: Practice Parameters with an Evidence-Based Literature Review and Meta-Analyses

    PubMed Central

    Aurora, R. Nisha; Chowdhuri, Susmita; Ramar, Kannan; Bista, Sabin R.; Casey, Kenneth R.; Lamm, Carin I.; Kristo, David A.; Mallea, Jorge M.; Rowley, James A.; Zak, Rochelle S.; Tracy, Sharon L.

    2012-01-01

    The International Classification of Sleep Disorders, Second Edition (ICSD-2) distinguishes 5 subtypes of central sleep apnea syndromes (CSAS) in adults. Review of the literature suggests that there are two basic mechanisms that trigger central respiratory events: (1) post-hyperventilation central apnea, which may be triggered by a variety of clinical conditions, and (2) central apnea secondary to hypoventilation, which has been described with opioid use. The preponderance of evidence on the treatment of CSAS supports the use of continuous positive airway pressure (CPAP). Much of the evidence comes from investigations on CSAS related to congestive heart failure (CHF), but other subtypes of CSAS appear to respond to CPAP as well. Limited evidence is available to support alternative therapies in CSAS subtypes. The recommendations for treatment of CSAS are summarized as follows: CPAP therapy targeted to normalize the apnea-hypopnea index (AHI) is indicated for the initial treatment of CSAS related to CHF. (STANDARD)Nocturnal oxygen therapy is indicated for the treatment of CSAS related to CHF. (STANDARD)Adaptive Servo-Ventilation (ASV) targeted to normalize the apnea-hypopnea index (AHI) is indicated for the treatment of CSAS related to CHF. (STANDARD)BPAP therapy in a spontaneous timed (ST) mode targeted to normalize the apnea-hypopnea index (AHI) may be considered for the treatment of CSAS related to CHF only if there is no response to adequate trials of CPAP, ASV, and oxygen therapies. (OPTION)The following therapies have limited supporting evidence but may be considered for the treatment of CSAS related to CHF after optimization of standard medical therapy, if PAP therapy is not tolerated, and if accompanied by close clinical follow-up: acetazolamide and theophylline. (OPTION)Positive airway pressure therapy may be considered for the treatment of primary CSAS. (OPTION)Acetazolamide has limited supporting evidence but may be considered for the treatment of primary CSAS. (OPTION)The use of zolpidem and triazolam may be considered for the treatment of primary CSAS only if the patient does not have underlying risk factors for respiratory depression. (OPTION)The following possible treatment options for CSAS related to end-stage renal disease may be considered: CPAP, supplemental oxygen, bicarbonate buffer use during dialysis, and nocturnal dialysis. (OPTION) Citation: Aurora RN; Chowdhuri S; Ramar K; Bista SR; Casey KR; Lamm CI; Kristo DA; Mallea JM; Rowley JA; Zak RS; Tracy SL. The treatment of central sleep apnea syndromes in adults: practice parameters with an evidence-based literature review and meta-analyses. SLEEP 2012;35(1):17-40. PMID:22215916

  2. Underground Lead-Zinc Mine Production Planning Using Fuzzy Stochastic Inventory Policy / Planowanie Wydobycia Cynku I Ołowiu W Kopalniach Podziemnych Z Wykorzystaniem Podejścia Stochastycznego Z Elementami Logiki Rozmytej Do Określania Niezbędnego Poziomu Zapasów

    NASA Astrophysics Data System (ADS)

    Gligoric, Zoran; Beljic, Cedomir; Gluscevic, Branko; Cvijovic, Cedomir

    2015-03-01

    Methodology for long-term underground lead-zinc mine planning based on fuzzy inventory theory is presented in this paper. We developed a fuzzy stochastic model of inventory control problem for planning lead-zinc ore production under uncertainty. The final purpose of this article is to find the optimal quantity of mined ore that should be stockpiled, in order to enable "feeding" of mineral processing plant in cases when the production in underground mine is interrupted, by using Possibilistic mean value of fuzzy number for defuzzing the fuzzy total annual inventory costs, and by using Extension of the Lagrangean method for solving inequality constrain problem. The different types of costs involved in mined ore inventory problems affect the efficiency of production scheduling. Dynamic nature of lead and zinc metal price is described by Ornstein-Uhlenbeck stochastic mean reverting process. The model is illustrated with a numerical example. W pracy przedstawiono metodologię długoterminowego wydobycia cynku i ołowiu w kopalniach podziemnych z wykorzystaniem podejścia stochastycznego z elementami logiki rozmytej do określania wymaganego poziomu zapasów. Opracowaliśmy model stochastyczny z wykorzystaniem elementów logiki rozmytej do kontroli zapasów w planowaniu wydobycia cynku i ołowiu w warunkach niepewności. Celem końcowym pracy jest określenie optymalnej ilości wydobywanej rudy, którą należy zachować jako zapas tak aby zapewnić odpowiednie jej dostawy do zakładu przeróbczego nawet w przypadku przerwania wydobycia w kopalni podziemnej, opierając się na posybilistycznej wartości średniej liczby rozmytej i wyostrzeniu całkowitych rocznych kosztów zapasów. Wykorzystano także rozszerzenie metody Lagrange'a do rozwiązywania problemu więzów w nierówności. Różnorakie koszty związane ze składowaniem zapasów wydobywanej rudy mają wpływ na wydajność planowanej produkcji. Dynamiczne zmiany cen cynku i ołowiu zostały określone z wykorzystaniem rewersji średniej stochastycznej, w pracy Ornsteina-Uhlenbecka. Zaprezentowano przykład numeryczny jako ilustrację modelu.

  3. Isotope characterisation of historical alabaster quarries in Western Europe.

    NASA Astrophysics Data System (ADS)

    Kloppmann, Wolfram; Leroux, Lise; Bromblet, Philippe; Cooper, Anthony H.; Nestler, Angela; Guerrot, Catherine; Montech, Anne-Thérèse; Worley, Noel

    2015-04-01

    The origin of the raw material of gypsum alabaster artwork is still largely underinvestigated as conventional chemical and mineralogical analyses have not yielded convincing results due to the rather homogeneous composition, especially of the most wanted pure white varieties. Yet, identifying the origin of raw materials used for sculpture is crucial for art historians and museums aiming at identifying artists, rarely nominally documented before the 16th century, workshops and historic trade roads. A pilot study (Kloppmann et al., 2014) revealed the potential of multi-isotope fingerprinting of alabaster provenance, using a combination of sulphur, oxygen and strontium isotopes. Here we present an enlarged data base of isotope analyses of samples from known or suspected historical alabaster exploitations in France (Jura, Alps, Provence, Burgundy, Lorraine, Aquitaine, Paris region), Spain (Aragon and Catalonia), England (East Midlands/Nottingham region, Cumberland, N Yorkshire), Germany (Harz Mountain foreland). Strontium and sulphur isotopes appear to be particularly discriminative with a strong inter-site variability and intra-site homogeneity. Isotope ratios of both elements in seawater and associated evaporites have strongly varied over geological timescales (Claypool et al. 1980; Burke et al. 1982; Denison et al. 1998) so that W-European alabaster samples, ranging from Permian (Zechstein) to Miocene ages, show age-specific differentiation. Additionally, for both elements, non-marine sources such as sulphides, organic sulphur and strontium derived from mineral weathering provide basin- or sub-basin-specific signatures that further discriminate alabaster provenances. Oxygen isotopes provide supplementary evidence even if there is a stronger overlap of signatures. In conclusion, we consider that we have now an operational tool to distinguish the main alabaster sources for historical workshops in Western Europe. This methodology is currently applied to sculptures ranging from the 14th to 16th century from the Louvre Museum, Cleveland Museum of Fine Arts, the Petit Palais Museum in Avignon and several regional collections and monuments. Burke W. H., Denison R. E., Hetherington E. A., Koepnick R. B., Nelson H. F., and Otto J. B. (1982) Variation of seawater 87Sr/86Sr throughout Phanerozoic time. Geology 10, 516-519. Claypool G. E., Holser W. T., Kaplan I. R., Sakai H., and Zak I. (1980) The age curves of sulfur and oxygen isotopes in marine sulfate and their mutual interpretation. Chem. Geol. 28, 199-260. Denison R. E., Kirkland D. W., and Evans R. (1998) Using strontium isotopes to determine the age and origin of gypsum and anhydrite beds. J. Geol. 106, 1-17. Kloppmann W., Leroux L., Bromblet P., Guerrot C., Proust E., Cooper A. H., Worley N., Smeds S. A., and Bengtsson H. (2014) Tracing Medieval and Renaissance Alabaster Works of Art Back to Quarries: A Multi-Isotope (Sr, S, O) Approach. Archaeometry 56, 203-219.

  4. Practice Parameters for the Use of Autotitrating Continuous Positive Airway Pressure Devices for Titrating Pressures and Treating Adult Patients with Obstructive Sleep Apnea Syndrome: An Update for 2007

    PubMed Central

    Morgenthaler, Timothy I.; Aurora, R. Nisha; Brown, Terry; Zak, Rochelle; Alessi, Cathy; Boehlecke, Brian; Chesson, Andrew L.; Friedman, Leah; Kapur, Vishesh; Maganti, Rama; Owens, Judith; Pancer, Jeffrey; Swick, Todd J.

    2008-01-01

    These practice parameters are an update of the previously published recommendations regarding the use of autotitrating positive airway pressure (APAP) devices for titrating pressures and treating adult patients with obstructive sleep apnea syndrome. Continuous positive airway pressure (CPAP) at an effective setting verified by attended polysomnography is a standard treatment for obstructive sleep apnea (OSA). APAP devices change the treatment pressure based on feedback from various patient measures such as airflow, pressure fluctuations, or measures of airway resistance. These devices may aid in the pressure titration process, address possible changes in pressure requirements throughout a given night and from night to night, aid in treatment of OSA when attended CPAP titration has not or cannot be accomplished, or improve patient comfort. A task force of the Standards of Practice Committee of the American Academy of Sleep Medicine has reviewed the literature published since the 2002 practice parameter on the use of APAP. Current recommendations follow: (1) APAP devices are not recommended to diagnose OSA; (2) patients with congestive heart failure, patients with significant lung disease such as chronic obstructive pulmonary disease; patients expected to have nocturnal arterial oxyhemoglobin desaturation due to conditions other than OSA (e.g., obesity hypoventilation syndrome); patients who do not snore (either naturally or as a result of palate surgery); and patients who have central sleep apnea syndromes are not currently candidates for APAP titration or treatment; (3) APAP devices are not currently recommended for split-night titration; (4) certain APAP devices may be used during attended titration with polysomnography to identify a single pressure for use with standard CPAP for treatment of moderate to severe OSA; (5) certain APAP devices may be initiated and used in the self-adjusting mode for unattended treatment of patients with moderate to severe OSA without significant comorbidities (CHF, COPD, central sleep apnea syndromes, or hypoventilation syndromes); (6) certain APAP devices may be used in an unattended way to determine a fixed CPAP treatment pressure for patients with moderate to severe OSA without significant comorbidities (CHF, COPD, central sleep apnea syndromes, or hypoventilation syndromes); (7) patients being treated with fixed CPAP on the basis of APAP titration or being treated with APAP must have close clinical follow-up to determine treatment effectiveness and safety; and (8) a reevaluation and, if necessary, a standard attended CPAP titration should be performed if symptoms do not resolve or the APAP treatment otherwise appears to lack efficacy. Citation: Morgenthaler TI; Aurora RN; Brown T; Zak R; Alessi C; Boehlecke B; Chesson AL; Friedman L; Kapur V; Maganti R; Owens J; Pancer J; Swick TJ; Standards of Practice Committee of the AASM. Practice parameters for the use of autotitrating continuous positive airway pressure devices for titrating pressures and treating adult patients with obstructive sleep apnea syndrome: An update for 2007. SLEEP 2008;31(1):141-147. PMID:18220088

  5. Exupéry - a mobile fast response system for managing a volcanic crisis

    NASA Astrophysics Data System (ADS)

    Hort, M. K.

    2009-12-01

    Despite ever increasing efforts to monitor historically active volcanoes many of those are still very poorly or unmonitored, even in highly populated areas. In case of volcanic unrest or even a volcanic crisis evaluating the situation is therefore often very difficult due to the little information that is available for that specific volcano. Over the past decades several different programs have supported volcanic crisis management efforts in third world countries from sending experts all the way to improving or even installing new networks around the volcano. One of the main problems especially when quickly upgrading networks during a crisis is that each system usually comes with its own acquisition and processing system which makes it very difficult to manage the observational network and provide an interdisciplinary interpretation of the data with respect to the activity status of the volcano. Here we present a newly developed volcano fast response system which overcomes several of these shortcomings. The core of the system is a novel database (SEISHUB) that allows for the collection of data of various kinds, i.e. simple time series data like seismic data, gas measurements, GPS measurements, as well as satellite data (SO2 flux, thermal anomaly, ground deformation). Part of the collected data may also come from an already existing network. Data from new field instruments are transmitted through a wireless network that has been specifically designed for the volcano fast response system. One of the main difficulties with such a multidisciplinary data set is an easy access to the data. This is provided through a common Web based GIS interface which allows various datalayers being simultaneously accessed through a Web Browser. The underlying software is designed in such a way that it only uses open source software, so it can be easily installed on other systems not having to deal with purchasing proprietary software. Aside from this the system provides tools to analyze the incoming data (e.g. earthquake classification, rapid moment tensor inversion, deformation modeling, an automatic alert level system) which are currently under development. Exupery Working Group: Barsch R (2); Bernsdorf S (3); Beyreuther M (2); Cong X (4); Dahm T (1); Eineder M (4); Erbertseder T (4); Gerstenecker C (5); Hammer C (6); Hansteen T (7); Krieger L (1); Läufer G (5); Maerker C (4); Montalvo Garcia A (1); Ohrnberger M (6); Rix M (4); Rödelsperger S (5); Seidenberger K (4); Shirzaei M (8); Stammler K (9); Stittgen H (9); Valks P (4); Walter T (8); Wallenstein N (10); Wassermann J (2); Zakšek K (1) (1)Institute of Geophysics, Hamburg, Germany; (2) Department of Earth and Environmental Sciences, Geophysical Observatory, Munich, Germany; (3)Centauron - geosoftware & consulting, Weimar, Germany; (4)DLR Oberpfaffenhofen, Germany; (5)Institute of Physical Geodesy, Darmstadt, Germany; (6)Institute of Geosciences, Potsdam, Germany; (7) IFM-GEOMAR, Leibniz Institute of Marine Sciences, Germany; (8)Department physics of the earth, GFZ, Potsdam, Germany; (9)BGR, Geocentre Hannover, Germany; (10)CVARG, Universidade Dos Acores; Portugal

  6. Safe Vibrations of Spilling Basin Explosions at "Gotvand Olya Dam" Using Artificial Neural Network

    NASA Astrophysics Data System (ADS)

    Bakhshandeh Amnieh, Hassan; Bahadori, Moein

    2014-12-01

    Ground vibration is an undesirable outcome of an explosion which can have destructive effects on the surrounding environment and structures. Peak Particle Velocity (PPV) is a determining factor in evaluation of the damage caused by an explosion. To predict the ground vibration caused by blasting at the Gotvand Olya Dam (GOD) spilling basin, thirty 3-component records (totally 90) from 19 blasts were obtained using 3 VIBROLOC seismographs. Minimum and the maximum distance from the center of the exploding block to the recording station were set to be 11 and 244 meters, respectively. To evaluate allowable safe vibration and determining the permissible explosive charge weight, Artificial Neural Networks (ANN) was employed with Back Propagation (BP) and 3 hidden layers. The mean square error and the correlation coefficient of the network in this study were found to be 1.95 and 0.995, respectively, which compared to those obtained from the known empirical correlations, indicating substantially more accurate prediction. Considering the network high accuracy and precision in predicting vibrations caused by such blasting operations, the nearest distance from the center of the exploding block at this study was 11 m, and considering the standard allowable vibration of 120 mm/sec for heavy concrete structures, the maximum permissible explosive weight per delay was estimated to be 47.00 Kg. These results could be employed in subsequent safer blasting operation designs. Wibracje gruntu to niepożądany skutek prowadzenia prac strzałowych, które mogą negatywnie wpływać na otaczające środowisko oraz znajdujące się w sąsiedztwie budowle. Głównym wskaźnikiem używanym przy określaniu szkód spowodowanych przez wybuchy jest wskaźnik maksymalnej prędkości cząstek (PPV). Przy prognozowaniu wibracji terenu wskutek prac strzałowych prowadzonych na tamie Gotvand Olya i w zbiorniku zbadano zapisy 3-składnikowych prędkości ( w sumie 90 zapisów) z 13 wybuchów zarejestrowane przy użyciu sejsmografu 3 VIBROLOC. Maksymalna i minimalna odległość pomiędzy środkiem rozkruszanego bloku a stacją rejestrującą ustawiona została na poziomie 244 i 11 m. W celu określenia bezpiecznego poziomu drgań oraz dopuszczalnej wagi ładunku, zastosowano podejście wykorzystujące sieci neuronowe, z wykorzystaniem metody propagacji wstecznej i trzech warstw ukrytych. Błąd średniokwadratowy i współczynnik korelacji sieci wyniosły 1.95 i 0.95, co pozostaje w zgodności z danym uzyskiwanymi z obserwacji empirycznych, wskazując na poprawność i dokładność prognoz. Zakładając wysoki poziom dokładności sieci oraz wysoką dokładność w prognozowaniu poziomu drgań wywołanych przez prace strzałowe, przyjęto że najbliższa odległość od środka rozkruszanego bloku wyniesie 11 m. Uwzględniając standardowe dopuszczalne w przypadku ciężkich budowli betonowych poziomy drgań w wysokości 120 m/s, oszacowano że maksymalna dopuszczalna masa ładunku wyniesie 47.00 Kg, w przeliczeniu na jeden okres zwłoki. Wyniki badań wykorzystane być mogą w planowaniu kolejnych bezpiecznych prac strzałowych.

  7. [Evaluation of using statistical methods in selected national medical journals].

    PubMed

    Sych, Z

    1996-01-01

    The paper covers the performed evaluation of frequency with which the statistical methods were applied in analyzed works having been published in six selected, national medical journals in the years 1988-1992. For analysis the following journals were chosen, namely: Klinika Oczna, Medycyna Pracy, Pediatria Polska, Polski Tygodnik Lekarski, Roczniki Państwowego Zakładu Higieny, Zdrowie Publiczne. Appropriate number of works up to the average in the remaining medical journals was randomly selected from respective volumes of Pol. Tyg. Lek. The studies did not include works wherein the statistical analysis was not implemented, which referred both to national and international publications. That exemption was also extended to review papers, casuistic ones, reviews of books, handbooks, monographies, reports from scientific congresses, as well as papers on historical topics. The number of works was defined in each volume. Next, analysis was performed to establish the mode of finding out a suitable sample in respective studies, differentiating two categories: random and target selections. Attention was also paid to the presence of control sample in the individual works. In the analysis attention was also focussed on the existence of sample characteristics, setting up three categories: complete, partial and lacking. In evaluating the analyzed works an effort was made to present the results of studies in tables and figures (Tab. 1, 3). Analysis was accomplished with regard to the rate of employing statistical methods in analyzed works in relevant volumes of six selected, national medical journals for the years 1988-1992, simultaneously determining the number of works, in which no statistical methods were used. Concurrently the frequency of applying the individual statistical methods was analyzed in the scrutinized works. Prominence was given to fundamental statistical methods in the field of descriptive statistics (measures of position, measures of dispersion) as well as most important methods of mathematical statistics such as parametric tests of significance, analysis of variance (in single and dual classifications). non-parametric tests of significance, correlation and regression. The works, in which use was made of either multiple correlation or multiple regression or else more complex methods of studying the relationship for two or more numbers of variables, were incorporated into the works whose statistical methods were constituted by correlation and regression as well as other methods, e.g. statistical methods being used in epidemiology (coefficients of incidence and morbidity, standardization of coefficients, survival tables) factor analysis conducted by Jacobi-Hotellng's method, taxonomic methods and others. On the basis of the performed studies it has been established that the frequency of employing statistical methods in the six selected national, medical journals in the years 1988-1992 was 61.1-66.0% of the analyzed works (Tab. 3), and they generally were almost similar to the frequency provided in English language medical journals. On a whole, no significant differences were disclosed in the frequency of applied statistical methods (Tab. 4) as well as in frequency of random tests (Tab. 3) in the analyzed works, appearing in the medical journals in respective years 1988-1992. The most frequently used statistical methods in analyzed works for 1988-1992 were the measures of position 44.2-55.6% and measures of dispersion 32.5-38.5% as well as parametric tests of significance 26.3-33.1% of the works analyzed (Tab. 4). For the purpose of increasing the frequency and reliability of the used statistical methods, the didactics should be widened in the field of biostatistics at medical studies and postgraduation training designed for physicians and scientific-didactic workers.

  8. The Application of Modern Techniques and Measurement Devices for Identification of Copper Ore Types and Their Properties / Wykorzystanie nowoczesnych technik i urządzeń pomiarowych do identyfikacji typów rud miedzi i ich właściwości

    NASA Astrophysics Data System (ADS)

    Krawczykowska, Aldona; Trybalski, Kazimierz; Krawczykowski, Damian

    2013-06-01

    The paper concerns the application of modern methods and research techniques for investigations of copper ore properties. It presents the procedure and tools which, when put together, can constitute a source of information on properties of different products of processing and, simultaneously, can be used in the process control and optimization. The copper ore of one of the branches of the KHGM Polska Miedz plc was investigated. The ore samples represented each of the three lithological types occurring in the Polish deposits, i.e. carbonate, shale and sandstone ores. The paper presents the results of microscopic analyses, image analysis of scanning photographs and application procedures of the obtained information for the identification of ore types (application of neuron networks to the recognition of lithological compositions). The present publication will present sample results of modelling of classification identifying two types of ores, i.e. carbonate-shale and sandstone. Summing up the predictions of ore type fractions in respective mixtures for the considered problem of classification it can be stated that the prediction results are good and confirm the lithological predominance of certain ore types in the investigated mixtures. The experimental part comprised the determination of mineralogical and lithological composition of ores (optical microscope) and also elemental composition in the microareas of analysed samples (scanning microscope). Next, the image analysis was performed and subsequently the models classifying the ore types were made. W rudzie miedzi przerabianej w zakładach wzbogacania O/ZWR KGHM Polska Miedź S.A. można wyróżnić trzy typy litologiczne: rudę węglanową, łupkową i piaskowcową. Typy te różnią się właściwościami między innymi takimi jak: rodzaj i zawartość minerałów miedzi, rodzaj minerałów nieużytecznych, zawartość miedzi, twardość i podatność na rozdrabnianie, ale także wielkością i kształtem ziaren minerałów miedzionośnych oraz rodzajem ich skupień i wpryśnięć. Niezwykle istotne jest właściwe rozpoznanie rudy pod względem petrograficzno-mineralogicznym. Znajomość właściwości przerabianej rudy pozwala na pełniejsze jej wykorzystanie poprzez właściwe prowadzenie i sterowanie procesami, dobór ich parametrów takich m.in. jak: czas mielenia, parametry klasyfikacji, rodzaj odczynników flotacyjnych, czas flotacji. W artykule przedstawiono wyniki przeprowadzonych analiz mikroskopowych, analizy obrazów zdjęć skaningowych oraz procedury wykorzystania otrzymanych informacji do identyfikacji typów rud (zastosowanie sieci neuronowych do rozpoznawania składów litologicznych). W badaniach wykorzystano rudę miedzi, pochodzącą z jednego z zakładów górniczych KGHM Polska Miedź S.A. Pobrane próbki rudy reprezentowały każdy z trzech typów litologicznych występujących w krajowych złożach: węglanową, łupkową oraz piaskowcową. Przeprowadzono ilościową analizę mineralogiczno-petrograficzną przy pomocy mikroskopu optycznego w świetle odbitym, a wyniki przedstawiono w tabelach 1 i 2. Wyniki te określają ilościowo stopień uwolnienia i zrosty dla jednego rodzaju minerału. Pokazano także przykładowe zdjęcia mikroskopowe zgładów poszczególnych typów litologicznych rud oraz próbek proszkowych tych typów (rys. 1 i 2). W kolejnym etapie badań wykorzystano skaningowy mikroskop elektronowy. Zdjęcia morfologii próbek uzyskane z mikroskopu elektronowego (obrazy SEM) były przedmiotem komputerowej analizy obrazu, umożliwiającej mikrostrukturalną klasyfikację ilościową typów rud. Analizowano wszystkie próbki poszczególnych typów litologicznych rudy miedzi: węglanowej, łupkowej i piaskowcowej oraz mieszanki tych typów w trzech klasach ziarnowych: 0÷45 μm, 45÷71 μm i 71÷100 μm. Celem przekształceń wykorzystanych w procedurze komputerowej analizy obrazu jest otrzymanie poprawnie posegmentowanego obrazu binarnego, który umożliwiałby wyróżnienie badanych obiektów - pojedynczych (poszczególnych) ziaren oraz tła, a następnie wykonanie pomiarów parametrów zbinaryzowanych obiektów. Spośród dużej ilości parametrów dostępnych w używanym oprogramowaniu do identyfikacji typów rud wybrano najważniejsze z punktu widzenia opisu ziaren. Obok parametrów opisujących podstawowe właściwości geometryczne tj. pole powierzchni, wysokość, szerokość, średnice Feret'a, oraz opisujących kształt ziaren, np. współczynniki wypełnienia, kolistości, wybrano parametry szarości obiektów. W tabeli 3 podano wartości statystyczne zmiennych wykorzystywanych w obliczeniach modelowych, dla jednego z materiałów. Do analizy uzyskanych danych wykorzystano sieci neuronowe. W niniejszej publikacji przedstawiono przykładowe wyniki modelowania dla zagadnienia klasyfikacji identyfikującego dwa typy rud: węglanowo-łupkową i piaskowcową. Połączenie rud: węglanowej i łupkowej w jeden typ ma swoje technologiczne uzasadnienie. Obliczenia modelujące wykonano przy użyciu komputerowego programu do modelowania Statistica Neural Networks firmy StatSoft. W tabeli 4 i 5 przedstawiono charakterystyki ostatecznych najskuteczniejszych modeli sieci neuronowych klasyfikujących typy rud. Ogólnie modele sieci neuronowych, realizujące zagadnienie klasyfikacji typów rud, charakteryzowały się wysoką jakością działania oraz małymi błędami sieci dla poszczególnych podzbiorów danych (uczącego, walidacyjnego i testowego). Świadczy to o ich wysokiej stabilności i pewności działania w przypadku uruchamiania sieci na nowych zbiorach danych. Weryfikacja zdolności predykcyjnych najskuteczniejszych modeli sieci neuronowych polegała na uruchomieniu sieci na nowych danych charakterystycznych dla poszczególnych mieszanek, oraz na porównaniu i ocenie uzyskanych przewidywań z rzeczywistymi udziałami poszczególnych typów rud miedzi w analizowanych mieszankach. Na rysunkach 6 i 7 przedstawiono wyniki przewidywań udziałów odmian litologicznych rud miedzi w mieszankach. Podsumowując przewidywania udziałów typów rud w poszczególnych mieszankach dla rozważanego zagadnienia klasyfikacji można stwierdzić, że wyniki przewidywań są dobre i potwierdzają przewagę litologiczną określonych odmian rud w badanych mieszankach. Szczególnie istotny z technologicznego punktu widzenia jest wysoki stopień trafności przewidywań typów rud dla szerokiej klasy ziarnowej, która odpowiada zazwyczaj rzeczywistemu składowi ziarnowemu nadawy do procesu flotacji. Trafność tych przewidywań jest większa dla mieszanek z przewagą rudy piaskowcowej.

  9. Extending the Standard Model with Confining and Conformal Dynamics

    NASA Astrophysics Data System (ADS)

    McRaven, John Emory

    This dissertation will provide a survey of models that involve extending the standard model with confining and conformal dynamics. We will study a series of models, describe them in detail, outline their phenomenology, and provide some search strategies for finding them. The Gaugephobic Higgs model provides an interpolation between three different models of electroweak symmetry breaking: Higgsless models, Randall-Sundrum models, and the Standard Model. At parameter points between the extremes, Standard Model Higgs signals are present at reduced rates, and Higgsless Kaluza-Klein excitations are present with shifted masses and couplings, as well as signals from exotic quarks necessary to protect the Zbb coupling. Using a new implementation of the model in SHERPA, we show the LHC signals which differentiate the generic Gaugephobic Higgs model from its limiting cases. These are all signals involving a Higgs coupling to a Kaluza-Klein gauge boson or quark. We identify the clean signal pp → W (i) → WH mediated by a Kaluza-Klein W, which can be present at large rates and is enhanced for even Kaluza-Klein numbers. Due to the very hard lepton coming from the W+/- decay, this signature has little background, and provides a better discovery channel for the Higgs than any of the Standard Model modes, over its entire mass range. A Higgs radiated from new heavy quarks also has large rates, but is much less promising due to very high multiplicity final states. The AdS/CFT conjectures a relation between Extra Dimensional models in AdS5 space, such as the Gaugephobic Higgs Model, and 4D Conformal Field theories. The notion of conformality has found its way into several phenomenological models for TeV-scale physics extending the standard model. We proceed to explore the phenomenology of a new heavy quark that transforms under a hidden strongly coupled conformal gauge group in addition to transforming under QCD. This object would form states similar to R-Hadrons. The heavy state would leave very little of its energy in the calorimeter, so while detecting the presence of a heavy stable state would be easy, measuring the strength of the detecting it would require accurate measurements of missing energy, or the ability to identify it in the muon tracker. We then study the phenomenology of a 4D model of electroweak symmetry breaking through the condensation of magnetic monopoles. A new generation of fermions with magnetic charges in addition to electric charges is introduced. The dyons condense and break the electroweak symmetry. The magnetic coupling is inversely proportional to the electric coupling, causing it to be strong. The processes involving magnetic couplings thus provide interesting phenomenology to study. We primarily study the processes involving di-photon production and compare it to early LHC results. Finally, we calculate triangle anomalies for fermions with non-canonical scaling dimensions. The most well known example of such fermions (aka unfermions) occurs in Seiberg duality where the matching of anomalies (including mesinos with scaling dimensions between 3/2 and 5/2) is a crucial test of duality. By weakly gauging the non-local action for an unfermion, we calculate the one-loop three-current amplitude. Despite the fact that there are more graphs with more complicated propagators and vertices, we find that the calculation can be completed in a way that nearly parallels the usual case. We show that the anomaly factor for fermionic unparticles is independent of the scaling dimension and identical to that for ordinary fermions. This can be viewed as a confirmation that unparticle actions correctly capture the physics of conformal fixed point theories like Banks-Zaks or SUSY QCD.

  10. Practice Parameters for the Respiratory Indications for Polysomnography in Children

    PubMed Central

    Aurora, R. Nisha; Zak, Rochelle S.; Karippot, Anoop; Lamm, Carin I.; Morgenthaler, Timothy I.; Auerbach, Sanford H.; Bista, Sabin R.; Casey, Kenneth R.; Chowdhuri, Susmita; Kristo, David A.; Ramar, Kannan

    2011-01-01

    Background: There has been marked expansion in the literature and practice of pediatric sleep medicine; however, no recent evidence-based practice parameters have been reported. These practice parameters are the first of 2 papers that assess indications for polysomnography in children. This paper addresses indications for polysomnography in children with suspected sleep related breathing disorders. These recommendations were reviewed and approved by the Board of Directors of the American Academy of Sleep Medicine. Methods: A systematic review of the literature was performed, and the American Academy of Neurology grading system was used to assess the quality of evidence. Recommendations for PSG Use: Polysomnography in children should be performed and interpreted in accordance with the recommendations of the AASM Manual for the Scoring of Sleep and Associated Events. (Standard) Polysomnography is indicated when the clinical assessment suggests the diagnosis of obstructive sleep apnea syndrome (OSAS) in children. (Standard) Children with mild OSAS preoperatively should have clinical evaluation following adenotonsillectomy to assess for residual symptoms. If there are residual symptoms of OSAS, polysomnography should be performed. (Standard) Polysomnography is indicated following adenotonsillectomy to assess for residual OSAS in children with preoperative evidence for moderate to severe OSAS, obesity, craniofacial anomalies that obstruct the upper airway, and neurologic disorders (e.g., Down syndrome, Prader-Willi syndrome, and myelomeningocele). (Standard) Polysomnography is indicated for positive airway pressure (PAP) titration in children with obstructive sleep apnea syndrome. (Standard) Polysomnography is indicated when the clinical assessment suggests the diagnosis of congenital central alveolar hypoventilation syndrome or sleep related hypoventilation due to neuromuscular disorders or chest wall deformities. It is indicated in selected cases of primary sleep apnea of infancy. (Guideline) Polysomnography is indicated when there is clinical evidence of a sleep related breathing disorder in infants who have experienced an apparent life-threatening event (ALTE). (Guideline) Polysomnography is indicated in children being considered for adenotonsillectomy to treat obstructive sleep apnea syndrome. (Guideline) Follow-up PSG in children on chronic PAP support is indicated to determine whether pressure requirements have changed as a result of the child's growth and development, if symptoms recur while on PAP, or if additional or alternate treatment is instituted. (Guideline) Polysomnography is indicated after treatment of children for OSAS with rapid maxillary expansion to assess for the level of residual disease and to determine whether additional treatment is necessary. (Option) Children with OSAS treated with an oral appliance should have clinical follow-up and polysomnography to assess response to treatment. (Option) Polysomnography is indicated for noninvasive positive pressure ventilation (NIPPV) titration in children with other sleep related breathing disorders. (Option) Children treated with mechanical ventilation may benefit from periodic evaluation with polysomnography to adjust ventilator settings. (Option) Children treated with tracheostomy for sleep related breathing disorders benefit from polysomnography as part of the evaluation prior to decannulation. These children should be followed clinically after decannulation to assess for recurrence of symptoms of sleep related breathing disorders. (Option) Polysomnography is indicated in the following respiratory disorders only if there is a clinical suspicion for an accompanying sleep related breathing disorder: chronic asthma, cystic fibrosis, pulmonary hypertension, bronchopulmonary dysplasia, or chest wall abnormality such as kyphoscoliosis. (Option) Recommendations against PSG Use: 16. Nap (abbreviated) polysomnography is not recommended for the evaluation of obstructive sleep apnea syndrome in children. (Option) 17. Children considered for treatment with supplemental oxygen do not routinely require polysomnography for management of oxygen therapy. (Option) Conclusions: Current evidence in the field of pediatric sleep medicine indicates that PSG has clinical utility in the diagnosis and management of sleep related breathing disorders. The accurate diagnosis of SRBD in the pediatric population is best accomplished by integration of polysomnographic findings with clinical evaluation. Citation: Aurora RN; Zak RS; Karippot A; Lamm CI; Morgenthaler TI; Auerbach SH; Bista SR; Casey KR; Chowdhuri S; Kristo DA; Ramar K. Practice parameters for the respiratory indications for polysomnography in children. SLEEP 2011;34(3):379-388. PMID:21359087

  11. Soil Aeration deficiencies in urban sites

    NASA Astrophysics Data System (ADS)

    Weltecke, Katharina; Gaertig, Thorsten

    2010-05-01

    Soil aeration deficiencies in urban sites Katharina Weltecke and Thorsten Gaertig On urban tree sites reduction of soil aeration by compaction or sealing is an important but frequently underestimated factor for tree growth. Up to 50% of the CO2 assimilated during the vegetation period is respired in the root space (Qi et al. 1994). An adequate supply of the soil with oxygen and a proper disposal of the exhaled carbon dioxide are essential for an undisturbed root respiration. If the soil surface is smeared, compacted or sealed, soil aeration is interrupted. Several references show that root activity and fine root growth are controlled by the carbon dioxide concentration in soil air (Qi et al.1994, Burton et al. 1997). Gaertig (2001) found that decreasing topsoil gas permeability leads to reduced fine root density and hence to injury in crown structure of oaks. In forest soils a critical CO2 concentration of more than 0.6 % indicates a bad aeration status (Gaertig 2001). The majority of urban tree sites are compacted or sealed. The reduction of soil aeration may lead to dysfunctions in the root space and consequently to stress during periods of drought, which has its visible affects in crown structure. It is reasonable to assume that disturbances in soil aeration lead to reduced tree vigour and roadworthiness, resulting in high maintenance costs. The assessment of soil aeration in urban sites is difficult. In natural ecosystems the measurement of gas diffusivity and the gas-chromatical analysis of CO2 in soil air are accepted procedures in analyzing the state of aeration (Schack-Kirchner et al. 2001, Gaertig 2001). It has been found that these methods can also be applied for analyzing urban sites. In particular CO2 concentration in the soil atmosphere can be considered as a rapidly assessable, relevant and integrating indicator of the aeration situation of urban soils. This study tested the working hypothesis that soil aeration deficiencies lead to a decrease of fine root density and tree vigour on urban soils. For that purpose gas diffusivity, soil CO2 concentrations and fine root density were measured on typical urban sites in the German cities of Göttingen, Mannheim, and Kassel. The known characteristics of soil aeration on forest sites could be affirmed for urban soils. A negative correlation was found between gas diffusion coefficients and CO2 concentration as well as between fine root extension and CO2 concentration. Changes in crown structure of beech indicating a loss of vigour were found at sites with disturbed aeration. Diffusivity patterns and CO2 concentrations of different specific urban soil sealing types were found. On more natural sites (mulch, grass) increased gas diffusion and low CO2 concentration were present. In contrast, on more compacted or sealed areas (asphalt, paving stone, macadamised road surface) the exchange between soil air and atmosphere was nearly disconnected and soil CO2 concentrations partly exceeded the known critical value of 0.6 % up to tenfold. Literature Burton, A. J.; Pregitzer, K. S.; Zogg, G. P. und Zak D. R. (1997): Effect of measurement CO2 concentrations on sugar maple root respiration. In: Canadian journal of Forest Research, H. 17, S. 421-427. Gaertig, T. (2001): Bodengashaushalt, Feinwurzeln und Vitalität von Eichen. In: Freiburger Bodenkundliche Abhandlungen, H. 40, S. 157. Qi, J.; Marshall, J. D.; Mattson, K. G. (1994): High soil carbon dioxide concentrations inhibit root respiration of Douglas fir. In: New Phytol., Jg. 128, H. 3, S. 435-442. Schack-Kirchner, H.; Gaertig, T.; Wilpert, K. v.; Hildebrand, E. E. (2001): A modified McIntyre and Phillip approach to measure top-soil gas diffusivity in-situ. In: J. Plant Nutr. Soil Sci., Jg. 164, S. 253-258.

  12. Methodology of Calculation the Terminal Settling Velocity Distribution of Spherical Particles for High Values of the Reynold's Number

    NASA Astrophysics Data System (ADS)

    Surowiak, Agnieszka; Brożek, Marian

    2014-03-01

    The particle settling velocity is the feature of separation in such processes as flowing classification and jigging. It characterizes material forwarded to the separation process and belongs to the so-called complex features because it is the function of particle density and size. i.e. the function of two simple features. The affiliation to a given subset is determined by the values of two properties and the distribution of such feature in a sample is the function of distributions of particle density and size. The knowledge about distribution of particle settling velocity in jigging process is as much important factor as knowledge about particle size distribution in screening or particle density distribution in dense media beneficiation. The paper will present a method of determining the distribution of settling velocity in the sample of spherical particles for the turbulent particle motion in which the settling velocity is expressed by the Newton formula. Because it depends on density and size of particle which are random variable of certain distributions, the settling velocity is a random variable. Applying theorems of probability, concerning distributions function of random variables, the authors present general formula of probability density function of settling velocity for the turbulent motion and particularly calculate probability density function for Weibull's forms of frequency functions of particle size and density. Distribution of settling velocity will calculate numerically and perform in graphical form. The paper presents the simulation of calculation of settling velocity distribution on the basis of real distributions of density and projective diameter of particles assuming that particles are spherical. Prędkość opadania ziarna jest cechą rozdziału w takich procesach przeróbki surowców jak klasyfikacja czy wzbogacanie w osadzarce. Cecha ta opisuje materiał kierowany do procesu rozdziału i należy do tzw. cech złożonych, ze względu na to, że jest funkcją dwóch cech prostych, którymi są: wielkość ziarna i gęstość ziarna. Przynależność do określonego podzbioru ziaren jest określona przez wartość dwóch cech, a rozkład tych cech w próbce jest funkcją rozkładów gęstości i wielkości ziarna. Znajomość rozkładu prędkości opadania ziaren w osadzarce jest istotnym parametrem jak znajomość rozkładu wielkości ziarna w procesie przesiewania czy znajomość rozkładu gęstości w procesie wzbogacania w cieczach ciężkich. W artykule przedstawiono metodykę wyliczania rozkładu prędkości opadania ziaren sferycznych w warunkach ruchu turbulentnego wyrażonego przy pomocy równania Newtona. Zarówno gęstość jak i wielkość ziarna są zmiennymi losowymi o określonych rozkładach. W związku z tym prędkość opadania ziarna jako funkcja cech prostych tj. gęstości i wielkości ziarna będzie również zmienną losową o rozkładzie, który jest funkcją rozkładów argumentów prostych. Wykorzystując twierdzenia rachunku prawdopodobieństwa odnoszące się do rozkładów funkcji zmiennych losowych przedstawiono ogólny wzór na funkcję gęstości rozkładu prędkości opadania w warunkach ruchu turbulentnego. Empiryczne rozkłady wielkości i gęstości ziaren aproksymowano rozkładem Weibulla. Rozkład prędkości opadania wyliczono numerycznie i przedstawiono w postaci graficznej. W artykule przedstawiono symulację wyliczania rozkładu prędkości opadania w oparciu o rzeczywiste rozkłady gęstości i średnicy projekcyjnej ziaren zakładając, że ziarna mają kształt sferyczny.

  13. Practice Parameters for the Surgical Modifications of the Upper Airway for Obstructive Sleep Apnea in Adults

    PubMed Central

    Aurora, R. Nisha; Casey, Kenneth R.; Kristo, David; Auerbach, Sanford; Bista, Sabin R.; Chowdhuri, Susmita; Karippot, Anoop; Lamm, Carin; Ramar, Kannan; Zak, Rochelle; Morgenthaler, Timothy I.

    2010-01-01

    Background: Practice parameters for the treatment of obstructive sleep apnea syndrome (OSAS) in adults by surgical modification of the upper airway were first published in 1996 by the American Academy of Sleep Medicine (formerly ASDA). The following practice parameters update the previous practice parameters. These recommendations were reviewed and approved by the Board of Directors of the American Academy of Sleep Medicine. Methods: A systematic review of the literature was performed, and the GRADE system was used to assess the quality of evidence. The findings from this evaluation are provided in the accompanying review paper, and the subsequent recommendations have been developed from this review. The following procedures have been included: tracheostomy, maxillo-mandibular advancement (MMA), laser assisted uvulopalatoplasty (LAUP), uvulopalatopharyngoplasty (UPPP),radiofrequency ablation (RFA), and palatal implants. Recommendations: The presence and severity of obstructive sleep apnea must be determined before initiating surgical therapy (Standard). The patient should be advised about potential surgical success rates and complications, the availability of alternative treatment options such as nasal positive airway pressure and oral appliances, and the levels of effectiveness and success rates of these alternative treatments (Standard). The desired outcomes of treatment include resolution of the clinical signs and symptoms of obstructive sleep apnea and the normalization of sleep quality, the apnea-hypopnea index, and oxyhemoglobin saturation levels (Standard). Tracheostomy has been shown to be an effective single intervention to treat obstructive sleep apnea. This operation should be considered only when other options do not exist, have failed, are refused, or when this operation is deemed necessary by clinical urgency (Option). MMA is indicated for surgical treatment of severe OSA in patients who cannot tolerate or who are unwilling to adhere to positive airway pressure therapy, or in whom oral appliances, which are more often appropriate in mild and moderate OSA patients, have been considered and found ineffective or undesirable (Option). UPPP as a sole procedure, with or without tonsillectomy, does not reliably normalize the AHI when treating moderate to severe obstructive sleep apnea syndrome. Therefore, patients with severe OSA should initially be offered positive airway pressure therapy, while those with moderate OSA should initially be offered either PAP therapy or oral appliances (Option). Use of multi-level or stepwise surgery (MLS), as a combined procedure or as stepwise multiple operations, is acceptable in patients with narrowing of multiple sites in the upper airway, particularly if they have failed UPPP as a sole treatment (Option). LAUP is not routinely recommended as a treatment for obstructive sleep apnea syndrome (Standard). RFA can be considered as a treatment in patients with mild to moderate obstructive sleep apnea who cannot tolerate or who are unwilling to adhere to positive airway pressure therapy, or in whom oral appliances have been considered and found ineffective or undesirable (Option). Palatal implants may be effective in some patients with mild obstructive sleep apnea who cannot tolerate or who are unwilling to adhere to positive airway pressure therapy, or in whom oral appliances have been considered and found ineffective or undesirable (Option). Postoperatively, after an appropriate period of healing, patients should undergo follow-up evaluation including an objective measure of the presence and severity of sleep-disordered breathing and oxygen saturation, as well as clinical assessment for residual symptoms. Additionally, patients should be followed over time to detect the recurrence of disease (Standard). Conclusions: While there has been significant progress made in surgical techniques for the treatment of OSA, there is a lack of rigorous data evaluating surgical modifications of the upper airway. Systematic and methodical investigations are needed to improve the quality of evidence, assess additional outcome measures, determine which populations are most likely to benefit from a particular procedure or procedures, and optimize perioperative care. Citation: Aurora RN; Casey KR; Kristo D; Auerbach S; Bista SR; Chowdhuri S; Karippot A; Lamm C; Ramar K; Zak R; Morgenthaler TI. Practice parameters for the surgical modifications of the upper airway for obstructive sleep apnea in adults. SLEEP 2010;33(10):1408-1413. PMID:21061864

  14. Determination of Critical Conditions of Spontaneous Combustion of Coal in Longwall Gob Areas / Wyznaczanie Warunków Krytycznych Samozapalania Węgla W Zrobach Ścian

    NASA Astrophysics Data System (ADS)

    Cygankiewicz, Janusz

    2015-09-01

    Decades of experience in the fight against endogenous fire hazard in coal mines indicate a major influence of certain conditions in a given area of the mine on the possibility of fire occurrence, such as: susceptibility of coals to spontaneous combustion, oxygen content in the air incoming to the self-heating coal, conditions of heat exchange between the self-heating coal mass and the environment This paper presents a numerical method for determining the critical conditions of spontaneous combustion of coal in longwall gob areas, i.e. conditions under which spontaneous combustion may occur. It has been assumed that crushed coal in the gob has a shape of a flat layer adjacent from the roof and floor side to the rocks. Our considerations have been limited to coals containing small amount of moisture. A simple model of oxidation kinetics on the coal surface expressed by the Arrhenius equation has been adopted. This model assumes that oxidation rate is independent of the amount of oxygen absorbed by coal. The rate of reaction depends only on temperature, with the parameters of the equation changing after the coal has reached the critical temperature. The article presents also a mathematical model of spontaneous heating of the coal layer in the gob area. It describes the heat balance in the coal as well as the oxygen and heat balance in the flowing gases. The model consists of a system of differential equations which are solved using numerical techniques. The developed computer program enables to perform the relevant calculations. In this paper, on the example of coal from a seam 405, we present the method for determining the following critical parameters of the layer of crushed coal: thickness of the layer, oxygen content in a stream of gases flowing through the layer and thermal conductivity of surrounding rocks. Wieloletnie doświadczenie w zakresie zwalczania zagrożenia pożarem endogenicznym w kopalniach wskazują na zasadniczy wpływ na możliwość zaistnienia pożaru niektórych warunków panujących w danym miejscu kopalni, takich jak: - skłonność węgla do samozapalania - zawartość tlenu w powietrzu dopływającym do zagrzewającego się węgla. W pracy przedstawiono numeryczną metodę wyznaczania warunków krytycznych samozapalania węgla w zrobach ścian, czyli takich po spełnieniu których może dojść do samozapalenia. Przyjęto, że znajdujący się w zrobach rozkruszony węgiel ma kształt płaskiej warstwy, sąsiadującej od stropu i spągu ze skałami. Rozważania ograniczono do węgli charakteryzujących się niską zawartością wilgoci. Przyjęto prosty model kinetyki utleniania na powierzchni węgla wyrażony równaniem Arrheniusa. Model ten zakłada niezależność szybkości utleniania od ilości tlenu pochłoniętego przez węgiel. Szybkość reakcji zależy jedynie od temperatury , przy czym występujące w równaniu parametry zmieniają się po osiągnięciu przez węgiel temperatury krytycznej. W artykule przedstawiono matematyczny model samozagrzewania warstwy węgla w zrobach opisujący bilans ciepła w węglu oraz bilans tlenu i bilans ciepła w przepływających gazach. Tworzące model układy równań różniczkowych cząstkowych rozwiązywane są metodami numerycznymi. Opracowany program komputerowy umożliwia wykonywanie stosownych obliczeń. W pracy, na przykładzie węgla z pokładu 405 , przedstawiono sposób wyznaczania warunków krytycznych warstwy rozkruszonego węgla: grubości warstwy, zawartości tlenu w przepływających przez warstwę gazach oraz przewodności cieplnej otaczających skał.

  15. Modelling of Underground Coal Gasification Process Using CFD Methods / Modelowanie Procesu Podziemnego Zgazowania Węgla Kamiennego Z Zastosowaniem Metod CFD

    NASA Astrophysics Data System (ADS)

    Wachowicz, Jan; Łączny, Jacek Marian; Iwaszenko, Sebastian; Janoszek, Tomasz; Cempa-Balewicz, Magdalena

    2015-09-01

    The results of model studies involving numerical simulation of underground coal gasification process are presented. For the purpose of the study, the software of computational fluid dynamics (CFD) was selected for simulation of underground coal gasification. Based on the review of the literature, it was decided that ANSYS-Fluent will be used as software for the performance of model studies. The ANSYS- -Fluent software was used for numerical calculations in order to identify the distribution of changes in the concentration of syngas components as a function of duration of coal gasification process. The nature of the calculations was predictive. A geometric model has been developed based on construction data of the georeactor used during the researches in Experimental Mine "Barbara" and Coal Mine "Wieczorek" and it was prepared by generating a numerical grid. Data concerning the georeactor power supply method and the parameters maintained during the process used to define the numerical model. Some part of data was supplemented based on the literature sources. The main assumption was to base the simulation of the georeactor operation on a mathematical models describing reactive fluid flow. Components of the process gas and the gasification agent move along the gasification channel and simulate physicochemical phenomena associated with the transfer of mass and energy as well as chemical reactions (together with the energy effect). Chemical reactions of the gasification process are based on a kinetic equation which determines the course of a particular type of equation of chemical coal gasification. The interaction of gas with the surrounding coal layer has also been described as a part of the model. The description concerned the transport of thermal energy. The coal seam and the mass rock are treated as a homogeneous body. Modelling studies assumed the coal gasification process is carried out with the participation of separately oxygen and air as a gasification agent, under the specific conditions of the georeactor operations within the time interval of 100 hours and 305 hours. The results of the numerical solution have been compared with the results of experimental results under in-situ conditions. Zaprezentowano wyniki badań modelowych polegających na numerycznej symulacji procesu podziemnego zgazowania węgla. Dla potrzeb realizowanej pracy dokonano wyboru oprogramowania wykorzystywanego do symulacji procesu podziemnego zgazowania węgla. Na podstawie przeglądu literatury zdecydowano, że oprogramowaniem, za pomocą, którego będą realizowane badania modelowe, będzie oprogramowanie informatyczne ANSYS-Fluent. Za jego pomocą przeprowadzano obliczenia numeryczne z zamiarem zidentyfikowania rozkładu zmian stężenia składników gazu procesowego w funkcji czasu trwania procesu zgazowania węgla. Przeprowadzone obliczenia miały charakter predykcji. W oparciu o dane konstrukcyjne georeaktora stosowanego podczas badań na KD Barbara oraz KWK Wieczorek, opracowano model geometryczny oraz wykonano jego dyskretyzację poprzez wygenerowanie odpowiedniej siatki numerycznej w oparciu, o którą wykonywane są obliczenia. Dane dotyczące sposobu zasilania georeaktora oraz parametrów utrzymywanych podczas procesu wykorzystano do definiowania modelu numerycznego. Część danych została uzupełniona w oparciu o źródła literaturowe. Głównym przyjętym założeniem było oparcie symulacji pracy georeaktora o modele opisujące reaktywny przepływ płynu. Składniki gazu procesowego oraz czynnik zgazowujący przemieszczają się wzdłuż kanału zgazowującego symulując zjawiska fizykochemiczne związane z transportem masy i energii oraz zachodzące reakcje chemiczne (wraz z efektem energetycznym). Chemizm procesu zgazowania oparto o równanie kinetyczne, które determinuje przebieg danego typu równania chemicznego zgazowania węgla. W ramach modelu opisano też interakcję gazu z otaczającą warstwą węgla. Opis ten dotyczył transportu energii cieplnej. Warstwę węgla oraz warstwy geologiczne otaczające georeaktor traktuje się jako ciało jednorodne. Badania modelowe zakładały prowadzenie procesu zgazowania calizny węglowej przy udziale, osobno tlenu i powietrza, jako czynnika zgazowującego, w warunkach ustalonych pracy georeaktora w przedziale czasu 100 godzin i 305 godzin. Uzyskane wyniki rozwiązania numerycznego zestawiono z wynikami badań eksperymentalnych w warunkach in-situ.

  16. Determining Acceptable Explosive Charge Mass Under Different Geological Conditions / Problematyka Wyznaczania Dopuszczalnych Ładunków Mw W Zróżnicowanych Warunkach Geologicznych

    NASA Astrophysics Data System (ADS)

    Pyra, Józef; Sołtys, Anna; Winzer, Jan; Dworzak, Michał; Biessikirski, Andrzej

    2015-09-01

    This article presents a procedure for determining the safety of explosive charges for their surrounding environment, using a limestone mine as a case study. Varied geological structures, as well as other constructions in the surrounding area of a mine, sometimes necessitate the use of two or more ground vibration propagation equations, and thus a variety of explosive charges, depending on the area of rock blasting. This is a crucial issue for the contractor, as it is important to blast the rock as few times as possible, while using the maximum amount of explosive charge for each blast. Wykonywanie robót strzałowych w górnictwie polega na odpalaniu mas materiału wybuchowego (MW) celem uzyskania dużej ilości odpowiednio rozdrobnionego urobku. W momencie zwiększonego popytu na surowce skalne zakłady górnicze zmuszone są do zwielokrotnienia wykonywania prac strzałowych aby zapewnić regularne dostawy produktu. Konsekwencją takich działań jest ponoszenie dodatkowych kosztów operacyjnych. Celem ich minimalizacji oraz uzyskania jak największej efektywności prowadzonych robót strzałowych jest wydłużanie serii, a więc stosowanie coraz to większych mas ładunków materiałów wybuchowych. Efektem takiego postępowanie jest możliwość wystąpienia w otoczeniu oddziaływania o potencjalnie szkodliwym charakterze m. in. drgania parasejsmiczne. Aby wyeliminować powyższy problem oraz zapewnić niezbędny komfort mieszkańcom, Prawo geologiczne i górnicze, Prawo ochrony środowiska i rozporządzenia wykonawcze nakładają na podmiot wykonujący roboty strzałowe obowiązek ochrony otoczenia, poprzez prowadzenie działalności profilaktycznej w zakresie kontroli, monitorowania oraz wyznaczania dopuszczalnych mas ładunków MW. W momencie gdy nie ma możliwości ograniczenia niepożądanych wpływów dynamicznych po przez zmianę parametrów siatki strzałowej czy modyfikację struktury czasowo-częstotliwościowej drgań, jedyną możliwością staje się ograniczenie całkowitej masy ładunków materiału wybuchowego odpalanego w całej serii oraz mas przypadających na pojedynczy stopień opóźnienia. Podejście takie stanowi w ostateczności jeden ze sposobów minimalizowania niekorzystnego oddziaływania drgań na obiekty budowlane znajdujące się w bezpośrednim otoczeniu kopalni. Metodyka wyznaczania dopuszczalnych mas ładunków MW dla danych warunków górniczo-geologicznych, mimo że w sposób szczegółowy opisana w literaturze fachowej oraz znajdująca szerokie zastosowanie, niekiedy musi zostać zmodyfikowana w zależności od odmiennej struktury masywu skalnego, warunków topograficznych oraz urbanizacyjnych. Zróżnicowana budowa geologiczna złoża oraz struktur geologicznych na których posadowione zostały chronione obiekty budowlane determinuje strukturę częstotliwościową i sposób propagowanych drgań. Istotą w takim przypadkach staje się określenie progu szkodliwości drgań, który pozwoli na bezpieczne prowadzenie robót bez możliwości wystąpienia uszkodzeń na obiektach chronionych zlokalizowanych w otoczeniu kopalń. Dodatkowo jak przedstawiono w artykule może dochodzić do sytuacji gdzie wykonywanie robót strzałowych w jednym miejscu wyrobiska może powodować zupełnie odmienną propagację drgań w różnych kierunkach. Rozpatrując powyższe względy oraz uwzględniając, że często ma się do czynienia z bardzo bliską zabudowę znajdującą się w otoczeniu kopalni niekiedy zachodzi konieczność wyznaczenia dwóch lub więcej równań propagacji drgań parasejsmicznych. Postępowanie takie prowadzi w konsekwencji do wyznaczenia różnych, często odmiennych, dopuszczalnych mas ładunków MW, których detonacja nie powinna powodować niekorzystnego wpływu na obiekty budowlane. Zależności te są zmienne w funkcji miejsca wykonywania robót strzałowych, a tym samym kwestia ta stanowi ważne zagadnienie z punktu widzenia przedsiębiorcy, którego głównym celem jest maksymalizacja jednorazowo odpalanej w serii masy ładunków MW przy równoczesnej minimalizacji liczby odpalanych serii. Jedyne utrudnienie, które może wynikać z wyznaczania w taki sposób ładunków oraz stosowania otrzymanych zależności może dotyczyć sposobu wykonywania robót strzałowych.

  17. New gravity control in Poland - needs, the concept and the design

    NASA Astrophysics Data System (ADS)

    Krynski, Jan; Olszak, Tomasz; Barlik, Marcin; Dykowski, Przemyslaw

    2013-06-01

    The existing Polish gravity control (POGK) established in the last few years of 20th century according to the international standards is spanned on 12 absolute gravity stations surveyed with four different types of absolute gravimeters. Relative measurements performed by various groups on nearly 350 points of POGK with the use of LaCoste&Romberg (LCR) gravimeters were linked to those 12 stations. The construction of the network, in particular the limited number of non homogeneously distributed absolute gravity stations with gravity determined with different instruments in different epochs is responsible for systematic errors in g on POGK stations. The estimate of those errors with the use of gravity measurements performed in 2007-2008 is given and their possible sources are discussed. The development of absolute gravity measurement technologies, in particular instruments for precise field absolute gravity measurements, provides an opportunity to establish new type of gravity control consisting of stations surveyed with absolute gravimeters. New gravity control planned to be established in 2012-2014 will consist of 28 fundamental points (surveyed with the FG5 - gravimeter), and 169 base points (surveyed with the A10 gravimeter). It will fulfill recent requirements of geodesy and geodynamics and it will provide good link to the existing POGK. A number of stations of the new gravity control with precisely determined position and height will form the national combined geodetic network. Methodology and measurement schemes for both absolute gravimeters as well as the technology for vertical gravity gradient determinations in the new gravity control were developed and tested. The way to assure proper gravity reference level with relation to ICAG and ECAG campaigns as well as local absolute gravimeter comparisons are described highlighting the role of metrology in the project. Integral part of the project are proposals of re-computation of old gravity data and their transformation to a new system (as 2nd order network) as well as a definition of gravity system as "zero-tide" system. Seasonal variability of gravity has been discussed indicating that the effects of environmental changes when establishing modern gravity control with absolute gravity survey cannot be totally neglected. Założona w Polsce w ostatniej dekadzie XX wieku zgodnie z obowiązującymi standardami międzynarodowymi Podstawowa Osnowa Grawimetryczna Kraju (POGK), składająca się z około 350 punktów, została oparta na 12 absolutnych punktach grawimetrycznych, na których przyspieszenie siły ciężkości wyznaczono przy użyciu czterech różnych typów grawimetrów absolutnych. Względne pomiary grawimetryczne na punktach tej osnowy, z jednoczesnym dowiązaniem jej do przyspieszenia siły ciężkości na 12 absolutnych punktach grawimetrycznych, wykonały różne grupy pomiarowe przy wykorzystaniu grawimetrów LaCoste&Romberg (LCR). Konstrukcja powstałej sieci grawimetrycznej, w szczególności ograniczona liczba nierównomiernie rozłożonych punktów absolutnych na terenie kraju, na których w dodatku przyspieszenie siły ciężkości wyznaczono różnymi instrumentami w różnych epokach, spowodowały wystąpienie błędów systematycznych w wartościach g na punktach POGK. W niniejszej pracy, przy wykorzystaniu pomiarów grawimetrycznych wykonanych w latach 2007-2008 dokonano oceny tych błędów oraz przeprowadzono dyskusję ich możliwych źródeł. Rozwój technologii absolutnych pomiarów grawimetrycznych, w szczególności instrumentów przeznaczonych do precyzyjnych absolutnych pomiarów grawimetrycznych w warunkach polowych, stwarza możliwość założenia nowego typu osnowy grawimetrycznej, składającej się ze stacji, na których przyspieszenie siły ciężkości jest pomierzone grawimetrami absolutnymi. Nowa osnowa grawimetryczna Polski, która będzie zakładana w latach 2012-2014, będzie się składała z 28 punktów fundamentalnych (mierzonych grawimetrem FG5) i 169 punktów bazowych (mierzonych grawimetrem A10). Będzie ona spełniała wymagania współczesnej geodezji i geodynamiki oraz zapewniała dobre powiązanie z istniejącą osnową POGK. Znaczna liczba punktów nowej osnowy grawimetrycznej, o precyzyjnie wyznaczonej pozycji wysokości utworzy krajową zintegrowaną osnowę geodezyjną. Opracowano i przetestowano metodologie i procedury pomiarowe na punktach nowej osnowy grawimetrycznej dla obu grawimetrów absolutnych (FG5, A10) oraz technologie wyznaczania gradientu pionowego przyspieszenia siły ciężkości na tych punktach. Określono metody zapewnienia odpowiedniego poziomu grawimetrycznego osnowy poprzez udział grawimetrów FG5 i A10 w międzynarodowej (ICAG) i europejskiej (ECAG), a także lokalnych kampaniach porównawczych grawimetrów absolutnych podkreślając jednocześnie rolę metrologii w projekcie. Integralnymi częściami projektu są zamierzenia przeliczenia archiwalnych danych grawimetrycznych wykorzystywanych przy tworzeniu POGK i ich przetransformowania do nowego systemu (jako sieć 2 rzędu) oraz zdefiniowania nowego systemu grawimetrycznego jako systemu "zero-tide". Przeprowadzono również dyskusję zmienności sezonowej przyspieszenia siły ciężkości wskazując, że przy wyznaczaniu przyspieszenia siły ciężkości na punktach nowoczesnej osnowy grawimetrycznej wpływ zmian środowiskowych nie może być traktowany jako w pełni zaniedbywalny.

  18. Trading forests for yields in the Peruvian Amazon

    NASA Astrophysics Data System (ADS)

    Gibbs, Holly

    2012-03-01

    Our knowledge of how agriculture expands, and the types of land it replaces, is remarkably limited across the tropics. Most remote-sensing studies focus on the net gains and losses in forests and agricultural land rather than the land-use transition pathways (Gibbs et al 2010). Only a handful of studies identify land sources for new croplands or plantations, and then only for farming systems aggregated together (e.g., Koh and Wilcove 2008, Morton et al 2006, Gibbs et al 2010). Gutiérrez-Vélez et al (2011), however, have taken a leap forward by tracking the different expansion pathways for smallholder and industrial oil palm plantations. Using a combination of Landsat, MODIS and field surveys, they investigate whether higher yields in new agricultural lands spare forests in the Peruvian Amazon and in a smaller focus area in the Ucayali region. Across the Peruvian Amazon, they show that between 2000 and 2010, new high-yield oil palm plantations replaced forests 72% of the time and accounted for 1.3% of total deforestation, with most expansion occurring after 2006. Gutiérrez-Vélez et al went further in the Ucayali region and compared land sources for new high-yield and low-yield plantations. Expansion of higher-yield agricultural lands should logically reduce the total area needed for production, thus potentially sparing forests. In the Ucayali focus area, expansion of high-yield oil palm did convert less total land area but more forest was cleared than with low-yield expansion. Smaller-scale plantations tended to expand into already cleared areas while industrial-scale plantations traded their greater yields for forests, leading to higher land-clearing carbon emissions per production unit (Gibbs et al 2008). Gutiérrez-Vélez et al show that higher yields may require less land for production but more forest may be lost in the process, and they emphasize the need for stronger incentives for land sparing. The potential land-saving nature of these high-yield plantations could be further analyzed by considering whether they help depress global prices, reducing incentives to expand elsewhere (Angelsen and Kaimowitz 2001). The significance of the study goes well beyond the bounds of Ucayli, and highlights risks to Amazonian forests from oil palm expansion (Butler and Laurance 2010). Oil palm is an astoundingly profitable and productive crop, with typical oil yields more than ten times that of soy. Some have even argued that oil palm is innately land sparing because it would take substantially more land for all other oil-bearing crops to provide the same output. However, most production gains from oil palm have occurred through increased area rather than increased yield, and in many cases expansion has been through forest clearing (Koh and Wilcove 2008, Gibbs et al 2010). The findings of Gutiérrez-Vélez et al (2011) are particularly significant considering that the booming palm oil sectors in Indonesia and Malaysia, which currently produce over 80% of the world's product, are facing a host of pressures that constrain future area expansion. Malaysia has little remaining land suited for plantations and Indonesia faces intensifying international scrutiny over the future of their forestlands. Consequently, the Amazon basin is widely considered the new frontier, with more than half of its forest area suitable for palm oil cultivation (Butler and Laurance 2010) and growing incentives from Brazil's Program for the Sustainable Production of Oil Palm, which aims to utilize degraded lands and spur reforestation efforts. Their results also illuminate another key issue, namely the constraints faced by large-scale producers when they seek to expand plantation area. Emerging demand-side conservation efforts, such as the Roundtable for Sustainable Palm Oil (RSPO), assume that already cleared and non-forested lands are freely available. Gutiérrez-Vélez et al (2011) hint at the obstacles to using such cleared lands, which is that they are inhabited and often have contested land tenure. We must carefully consider our consumption of these commodities in the face of growing land scarcity (Lambin and Meyfroidt 2011). If high-yield plantations displace low-yield plantations they too may follow the path of industrial agriculture and resume destruction of the forests that conservation efforts aim to protect. Without clear incentives to spare land, we could be trading forest for higher yields. References Angelsen A and Kaimowitz D 2001 Agricultural Technologies and Tropical Deforestation (New York: CABI Publishing) (www.cifor.org/publications/pdf files/books/bangelsen0101e0.pdf) Butler R and Laurance W 2010 Is oil palm the next emerging threat to the Amazon? Trop. Conserv. Sci. 2 1-10 Gibbs H K, Johnston M, Foley J A, Holloway T, Monfreda C, Ramankutty N and Zaks D 2008 Carbon payback times for crop-based biofuel expansion in the tropics: the effects of changing yield and technology Environ. Res. Lett. 3 034001 Gibbs H K, Ruesch A S, Achard F, Clayton M K, Holmgren P, Ramankutty N and Foley J A 2010 Tropical forests were the primary sources of new agricultural land in the 1980s and 1990s Proc. Natl Acad. Sci. 107 16732-7 Gutiérrez-Vélez V H, DeFries R, Pinedo-Vásquez M, Uriarte M, Padoch C, Baethgen W, Fernandes K and Lim Y 2011 High-yield oil palm expansion spares land at the expense of forests in the Peruvian Amazon Environ. Res. Lett. 6 044029 Koh L and Wilcove D 2008 Is oil palm agriculture really destroying tropical biodiversity? Conserv. Lett. 1 60-4 Lambin E and Meyfroidt P 2011 Inaugural article: global land use change, economic globalization, and the looming land scarcity Proc. Natl Acad. Sci. 108 93465-72 Morton D C et al 2006 Cropland expansion changes deforestation dynamics in the southern Brazilian Amazon Proc. Natl Acad. Sci. USA 103 14637-41

  19. Geotechnical Aspects of Revitalisation of Post-Mining Areas - An Example of the Adaptation of Katowice Hard Coal Mine for the New Silesian Museum / Geotechniczne aspekty rewitalizacji terenów pogórniczych - przykład adaptacji KWK "KATOWICE" na nowe muzeum śląskie

    NASA Astrophysics Data System (ADS)

    Cała, Marek; Ostręga, Anna

    2013-06-01

    The article presents the history of the Katowice Hard Coal Mine and the concept of revitalisation taking into consideration the historical development of the mine which today is closed. The concept accepted for realisation assumes adaptation of the post-mining area with its historical infrastructure for cultural functions, and namely for the construction of the New Silesian Museum. Basing the concept on the idea of minimum interference into the existing spatial layout of the former mine has had the result that the museum areas and garages have been designed under the surface of the area adjacent to the historic facilities of the mine. In relation therewith, it was necessary to carry out the works aimed at reinforcing foundations of the historic buildings and protecting the geotechnical pit slopes. The article presents the technological solutions applied to protect the historic buildings, the lift tower, and the excavations for new facilities of the Silesian Museum. Attention was drawn to the instability of the subsoil and of the rock mass due to previous mining operations conducted in the area, the need to adapt the protection technology to the existing conditions as well as the need of constant monitoring of geotechnical works underway.> It is emphasised that the presented investment is part of an ongoing process aimed at preserving the industrial part of the material cultural heritage of Upper Silesia, for centuries connected with hard coal mining and as such it stands a chance to become a showcase not only for Katowice but for the entire region of Silesia. W artykule przedstawiono historię Kopalni Węgla Kamiennego "Katowice" oraz koncepcję rewitalizacji uwzględniającą historyczną zabudowę nieczynnej już dziś kopalni. Przyjęta do realizacji koncepcja zakłada przystosowanie pogórniczego terenu wraz z zabytkową infrastrukturą dla funkcji kulturowych, a mianowicie budowy Nowego Muzeum Śląskiego. Siedziba Nowego Muzeum Śląskiego lokalizowana jest w południowej części terenu dawnej Kopalni "Katowice", na którym znajdują się zabytkowe obiekty przeznaczone do odrestaurowania i adaptacji dla nowych funkcji. Są to: - budynek maszyny wyciągowej Szybu "Warszawa" (MS-8), adaptowany dla celów gastronomicznych, - magazyn odzieżowy (MS-15), adaptowany dla celów wystawienniczych-Centrum Scenografii Polskiej, - wieża wyciągowa Szybu "Warszawa" (MS-79), adaptowana dla funkcji widokowych. Pozostała część terenu dawnej KWK "Katowice" wraz zabytkowymi obiektami, w miarę możliwości finansowych włączana będzie w kompleks Muzeum Śląskiego. Oparcie koncepcji na idei minimalnej ingerencji w urbanistyczny układ zabytkowej kopalni, a jednocześnie potrzeba zapewnienia odpowiednich przestrzeni wystawienniczych, administracyjnych i miejsc postojowych znalazły odzwierciedlenie w zastosowaniu następujących rozwiązań: - adaptacji historycznych obiektów dla funkcji wystawienniczych, gastronomicznych i widokowych; - ulokowania nowobudowanych obiektów pod powierzchnią terenu w bezpośrednim sąsiedztwie zabytkowych obiektów. W związku z powyższym koniecznym było wykonanie prac wzmacniających posadowienie historycznych budynków oraz geotechnicznych zabezpieczeń skarp wykopu. W artykule pokazano technologiczne rozwiązania jakie zastosowano dla zabezpieczenia zabytkowych budynków, wieży wyciągowej oraz wykopu pod nowe obiekty Muzeum Śląskiego. Geotechniczne metody zabezpieczenia poszczególnych obiektów zaprojektowano na podstawie rozpoznania warunków geologiczno-inżynierskich oraz wykonanych analiz, co pozwoliło na zaproponowanie rozwiązań optymalnych zarówno pod względem technicznym jak i ekonomicznym. Z uwagi na skomplikowane uwarunkowania geotechniczne i wartość obiektów znajdujących się w strefie oddziaływania wykopu, przewidziano zastosowanie technologii pozwalającej uzyskać efekt maksymalnego wzmocnienia wgłębnego masywu. Zaprojektowane technologie zabezpieczenia mają na celu: - wzmocnienie posadowienia zabytkowych obiektów i przeniesienie obciążeń na grunt poniżej dna wykopu; - umożliwienie wykonania wewnętrznego poziomu -1 poprzez pogłębienie części budynku maszynowni (MS-8) o jeden poziom; - zabezpieczenie geotechniczne ścian wykopu w rejonie historycznych budynków, - zapewnienie bezpieczeństwa pracy przez okres realizacji podziemnych części Nowego Muzeum Śląskiego jak również funkcjonowania obiektu po zakończeniu procesu rewitalizacji - konstrukcje oporowe przy budynku magazynu odzieży MS-15 i wieży wyciągowej MS-79 będą pełniły rolę docelowych ścian segmentów podziemnych. W artykule zwrócono uwagę na zróżnicowaną budowę geologiczną w rejonie inwestycji, różne obciążenie naziomu, a przede wszystkim na niepewność podłoża i masywu ze względu na wcześniej prowadzone roboty górnicze. Prowadzona przez 176 lat podziemna eksploatacja złóż węgla kamiennego spowodowała osłabienie masywu poprzez m.in. występowanie wkładek węgla kamiennego i stref uskokowych oraz prawdopodobnie starych zrobów. W zależności od rodzaju obiektu będącego przedmiotem zabezpieczenia, jak również konieczności dostosowania technologii zabezpieczenia do zastanych warunków zastosowano kilka rodzajów konstrukcji takich jak palisady czy też bariery mikropalowe stabilizowane kotwiami lub gwoździami. Z uwagi na charakter prac zabezpieczających, dokładność rozpoznania geologiczno-inżynierskiego oraz skalę zadania, projekt zabezpieczeń geotechnicznych miał charakter aktywny. Oznacza to, że rozwiązanie projektowe dostosowywano na bieżąco do faktycznie napotkanych warunków geologicznych. Ponadto podczas realizacji wszystkich prac zabezpieczających wykonywany był monitoring geotechniczny. Ze względu na zabytkowy charakter obiektów sąsiadujących z wykopem konieczny był również monitoring ich konstrukcji. Przedsięwzięcie realizowane jest przy wparciu Europejskiego Funduszu Rozwoju Regionalnego w ramach Regionalnego Programu Operacyjnego Województwa Śląskiego na lata 2007-2013 oraz środków Ministra Kultury i Dziedzictwa Narodowego. Zakończenie realizacji planuje się na 2013 r. Wartością dodaną opisanego przedsięwzięcia jest fakt ulokowania nowej siedziby Muzeum Śląskiego na terenie dawnej Kopalni "Katowice". Zabytkowa zabudowa dawnej Kopalni sama w sobie tworzy "żywe muzeum" górnictwa węglowego. Poza ekspozycjami związanymi z malarstwem, rzeźbą itp., w muzeum planuje się prezentować również przemysłowe dziedzictwo kulturowe Górnego Śląska. Rozpoczęto już gromadzenie eksponatów. Dlatego w artykule podkreślono, że opisana inwestycja wpisuje się w działania na rzecz zachowania przemysłowej części materialnego dziedzictwa kulturowego Górnego Śląska, od wieków związanego górnictwem węgla kamiennego i ma szansę stać się wizytówką nie tylko Katowic, ale i regionu śląskiego.

  20. Waterproof Anti-Explosive Powders for Coal Mines

    NASA Astrophysics Data System (ADS)

    Buczek, Bronisław; Vogt, Elżbieta

    2014-03-01

    Limestone powder characterized by hydrophobic properties is used as an anti-explosive agent in coal mining industry. Unfortunately, the standard method of producing such powder by milling limestone with stearic acid is practically unprofitable in many modernized quarries and plants, and sometimes literally impossible due to the introduction of technological changes and implementation of modern mills. Then new methods of hydrophobization of limestone surfaces ought be searched. In the work two methods hydrophobization: from the stearic acid vapour phase and from silicone solutions are proposed. Lime dust from the Czatkowice Quarry of Lime was used as a raw material during investigations. It is a good agent for research because it is possible to compare the properties of samples modified in this work to the properties of anti-explosive lime powder (Polish Standard, 1994) used in mining industry in Poland. The first technique of limestone powder hydrophobization was carried out in an apparatus of own design (Vogt, 2008, 2011), and it consisted in free sedimentation of the powder layer dispersed by stearic acid vapour in powder counter current flow. The second way of modification consisted in mixing in the evaporating dish substrates: limestone powder and dope - silicone solution - Sarsil® H-15 (Vogt & Opaliński, 2009; Vogt & Hołownia, 2010). Evaluation of properties so-obtained waterproof powders was carried out according to the Polish Standard, as well as using original powder determination ways, with the Powder Characteristic Tester (Index tables, Tablets & Capsules, 2005). Moreover water vapour adsorption isotherms were obtained and the thermal decomposition of powder was made. All modified samples acquired the hydrophobic character. Therefore we can state that the both proposed methods of hydrophobization of the limestone powder are useful. The parameters obtained with the use of Powder Characteristics Tester enable us to make a characterization of limestone properties not only as a water resistant material but also from the cohesion point of view. On the base of TG, DTG or DTA and EGA curves for all investigated materials was stated that the character of the thermal decomposition of modified samples is the same as this one for raw powder, what is profitable for application of hydrophobized powders as an anti-explosive agent. W górnictwie węgla kamiennego używany jest hydrofobowy pył wapienny jako substancja stosowana w systemie zabezpieczeń przeciwwybuchowych (Cybulski, 2004). Niestety, dotychczasowy sposób wy- twarzania takiego produktu polegający na współmieleniu kamienia wapiennego z kwasem stearynowym staje się praktycznie niemożliwy do stosowania w nowoczesnych zakładach np. kamieniołomy. Sytuacja taka jest wynikiem wprowadzania zmian technologicznych, głównie związanych z wymianą starych konstrukcji młynów na nowe urządzenia. Tym samym istnieje potrzeba poszukiwania nowych metod hydrofobizacji powierzchni pyłów wapiennych. W pracy omówiono dwie nowe metody hydrofobizacji pyłu wapiennego: za pomocą par kwasu stearynowego oraz roztworu silikonowego - Sarsil® H-15. Podczas badań używano surowego pyłu wapiennego pochodzącego z Kopalni Kamienia Wapiennego w Czatkowicach. Materiał ten jest dobrym materiałem do badań gdyż istnieje możliwość porównywania właściwości materiałów hydrofobowych otrzymanych w pracy z właściwościami handlowego pyłu przeciwwybuchowego (Polska Norma, 1994), używanego w polskich kopalniach. Pierwszy sposób hydrofobizacji pyłu wapiennego, polegający na swobodnym opadaniu pyłu wapiennego w oparach kwasu stearynowego przepływających w przeciwprądzie, przeprowadzono w aparacie własnej konstrukcji (Vogt, 2008, 2011). Aparat gwarantuje dobry kontakt modyfikatora z ziarnami pyłu. Pył opadając, nie napotyka żadnych przeszkód ulegał rozproszeniu, a wprowadzony w stanie parowym kwas stearynowy może swobodnie osiadać na jego powierzchni zewnętrznej oraz penetrować w głąb porów, blokując je dla wilgoci. Drugi sposób hydrofobizacji sprowadzał się w uproszczeniu do zmieszania substratów: pyłu wapiennego i domieszki silikonowej - Sarsil® H-15, w parownicy (Vogt i Opaliński, 2009; Vogt i Hołownia, 2010). We wstępnych badaniach określono objętość preparatu, jaką trzeba dodać do pyłu w celu uzyskania optymalnych warunków kontaktu preparatu z ciałem stałym. Otrzymany po modyfikacji materiał był zbrylony w niewielkim stopniu, a jego całkowite rozdrobnienie uzyskano poprzez przecieranie pyłu przez sito o odpowiednim wymiarze oczek. Badanie właściwości tak otrzymanych hydrofobowych materiałów przeprowadzono w oparciu o PN (Polska Norma, 1994), jak również w oparciu o standardowe metody badania materiałów proszkowych z użyciem aparatu Powder Characteristic Tester (Index tables, Tablets & Capsules, 2005) (Tablica 2,3). Oceny stopnia hydrofobizacji materiałów po modyfikacji dokonano, w przypadku proszku hydrofobizowanego parami kwasu stearynowego, w oparciu o procedurę opisaną w Polskiej Normie (1994), oznaczając procentową zawartość kwasu stearynowego. Otrzymany podczas badań pył hydrofobizowany kwasem stearynowym zawierał 0,18% modyfikatora, co jest ilością dopuszczalną przez Polską Normę (1994).W celu oceny właściwości hydrofobowych materiału modyfikowanego roztworem silikonowym do badań zaadaptowano technikę pomiaru zwilżalności ziaren węglowych "film flotation" (Fuerstenau i Williams, 1987) przyjmując, jako materiał odniesienia hydrofobizowaną mączkę wapienną z Kopalni Kamienia Wapiennego w Małogoszczy. Opracowano metodę wyznaczania współczynnika C określonego, jako stopień hydrofobizacji (Vogt i Opaliński, 2009). Średnia wartość C = 84% wskazuje, że materiał modyfikowany preparatem silikonowym uzyskał odpowiednie właściwości hydrofobowe. Tym samym oba materiały po modyfikacji uzyskały zadowalające właściwości wodoodporne. Ponadto, dla badanych pyłów wyznaczono izotermy adsorpcji pary wodnej (Rys. 1). Uzyskane niższe wartości adsorpcji dla materiałów po modyfikacji niż dla proszku surowego potwierdzają, że materiały posiadają charakter hydrofobowy, co pozwala stwierdzić, że obie proponowane metody hydrofobizacji są użyteczne do produkcji wodoodpornego pyłu wapiennego. Analizę termiczną pyłów wapiennych wykonano w celu porównania efektu cieplnego przemian zachodzących podczas ogrzewania pyłów modyfikowanych z efektem cieplnym zachodzącym podczas ogrzewania surowego pyłu wapiennego. W trakcie badań użyto termowagę firmy TA Instruments 2960 SDT ze sprzężonym spektrometrem masowym firmy Balzers TermoStar 300. Otrzymane wynikiprzedstawiono na Rys. 2. Linie ciągłe na Rys. 2a i 2b przedstawiają przebieg krzywych TG, DTG oraz DTA dla pyłu surowego. Linie przerywane zostały otrzymane dla pyłu modyfikowanego kwasem stearynowym (Rys. 2a) oraz preparatem SARSIL® H-15 (Rys. 2b). Na Rys. 3 zobrazowano wyniki analizy zawartości tlenku węgla IV w składzie gazów otrzymywanych podczas rozkładu termicznego pyłu wapiennego (EGA). Krzywa otrzymana dla pyłu modyfikowanego kwasem stearynowym w zasadzie pokrywa się z krzywą otrzymaną dla pyłu surowego. Parametry uzyskane z użyciem aparatu Powder Characteristics Tester umożliwiły scharakteryzowanie pyłów wapiennych nie tylko pod kątem ich właściwości hydrofobowych, ale także właściwości kohezyjnych i przepływowych.

  1. Unique Project of Single-Cutting Head Longwall Shearer Used for Thin Coal Seams Exploitation / Projekt Jednoorganowego Kombajnu ŚCIANOWEGO O Specjalnej Konstrukcji Przeznaczonego do Eksploatacji POKŁADÓW Cienkich

    NASA Astrophysics Data System (ADS)

    Bołoz, Łukasz

    2013-12-01

    Problem of thin hard coal seams exploitation, including chosen data related with their resources in Poland, has been discussed in the introduction of the present study. On the basis of actually operated machines the assumptions, which should be satisfied by the longwall shearer used for exploitation of thin hard coal seams, have been made. A project of such longwall shearer combined with band conveyor and mechanized longwall support, including description of the machine operation technology and analysis of possible day output achievement, have been presented. Polska dysponuje stosunkowo dużymi zasobami surowców energetycznych, a ciągle rosnące zapotrzebowanie na energię skłania do ich racjonalnego wykorzystywania. Jedną z możliwości takiego racjonalnego gospodarowania zasobami naturalnymi jest eksploatacja węgla kamiennego z pokładów cienkich. W związku z wybieraniem coraz cieńszych pokładów węgla, zalegających bardzo głęboko, w trudnych warunkach górniczo-geologicznych napotyka się na duże problemy związane z uzyskaniem wymaganej wydajności wydobycia przy użyciu stosowanych aktualnie metod. Przyjmuje się, ze pokłady cienkie to takie o miąższości od 1.0 m do 1.5 m i właśnie ta niewielka wysokość wyrobiska ścianowego powoduje szereg ograniczeń związanych z efektywną eksploatacją węgla. Na podstawie dostępnych danych określono, że ilości węgla kamiennego w cienkich pokładach wynosi około 600 mln Mg. Znaczna część pokładów cienkich w ostatnich latach została przeklasyfikowana na nieprzemysłowe, co pozwala stwierdzić, że rzeczywista ilość węgla w pokładach cienkich jest znacznie większa. Na podstawie analizy wad i zalet jak i danych technicznych produkowanych obecnie maszyn, określono wytyczne i założenia do nowego rozwiązania maszyny urabiającej przeznaczonej do wydobywania węgla w ścianach niskich. Kombajn do eksploatacji cienkich pokładów powinien spełniać następujące wymagania (Bołoz, 2012): • praca w systemie ścianowym, • zastosowanie frezowania jako metody skrawania, • rozdzielenie procesu frezowania od procesu ładowania, • zastosowanie pełnej automatyzacja pracy, • zastosowanie cięgnowego systemu posuwu, • możliwość rozpoczynania nowego skrawu bez konieczności zawrębiania, • gabaryty dostosowane do pracy w ścianach o wysokości od 1.0 m do 1.6 m, praca systemem dwukierunkowym. Fig. 2 przedstawia koncepcję kombajnu jednoorganowego. Kombajn ten składa się z kadłuba 2, jednego zamocowanego centralnie organu urabiającego 1 oraz dwóch rozkładanych ładowarek odkładniowych 3 i 4. Ładowarka 3 znajduje się w pozycji czynnej, natomiast ładowarka 4 w biernej. Kombajn jest ciągnięty po rynnach przenośnika 5 za pomocą łańcucha 6. Łańcuch 7 jest gałęzią bierną dla przedstawionego zwrotu prędkości. Podane, orientacyjne wymiary wynikają z analizy dotychczasowych rozwiązań kombajnów, głowic strugowych oraz założonego zakresu wysokości wyrobiska ścianowego (Krauze, 2006; Bołoz, 2012). Dla zaproponowanego rozwiązania przyjęto szereg koniecznych wielkości i przeprowadzono analizę możliwego do uzyskania wydobycia dobowego. Zestawione tabelarycznie wyniki umożliwiają określenie wydobycia dobowego możliwego do uzyskania przy określonych wartościach parametrów geometrycznych ściany, kinematycznych kombajnu oraz organizacyjnych pracy ściany. Dla założonych parametrów można stwierdzić, że minimalne wydobycie dobowe na poziomie Vd = 4032 Mg/d uzyskano dla L = 180 m, tp = 11 min, H = 1.0 m oraz T = 12 h/d. Maksymalne wydobycie dobowe na poziomie Vd = 11 612 Mg/d uzyskać można dla L = 300 m, tp = 0 min, H = 1.6 m oraz T = 18 h/d. Na wydobycie dobowe największy wpływ ma dobowy czas pracy ściany a następnie czas przekładki (Bołoz, 2012). Średnica organu dla takiego kombajnu dobierana jest do grubości pokładu. W przedmiotowym rozwiązaniu przyjęto organ o konstrukcji przestrzennej (belki nożowe zamiast płatów), aby powstający podczas frezowania urobek mógł spadać na spąg (Krauze, 2012b). Przykładowe rozwiązanie organu przestrzennego przedstawia fig. 3. Funkcję ładowania, realizowaną normalnie przez płaty, przejmują ładowarki. Rozdzielenie procesu ładowania od procesu frezowania jest jedną z najważniejszych zalet prezentowanego rozwiązania. Podczas pracy w ścianie parametry kinematyczne kombajnu mogą być zwiększane bez ryzyka wystąpienia problemów z ładowaniem na przenośnik, co obok możliwości ruchowych kombajnisty było głównym czynnikiem hamującym wzrost wydobycia. Załadunek urobku na przenośnik odbywa się za pomocą ładowarki, która po zmianie kierunku urabiania składa się, natomiast druga ustawiana jest w pozycji roboczej (Krauze, 2010). Kombajn porusza się tradycyjnie po rynnie przenośnika, jednak przy zastosowaniu cięgnowego systemu posuwu, który zrealizowany jest za pomocą napędów znajdujących się w chodnikach. Rozwiązanie takie umożliwia znaczne zmniejszenie gabarytów kombajnu dzięki usunięciu ciągników z kadłuba. Należy zaznaczyć, że w prezentowanym rozwiązaniu zakłada się zastosowanie pełnej automatyzacja pracy kombajnu i pozostałych maszyn ścianowych, co pozwala na urabianie calizny bez obecności załogi bezpośrednio w wyrobisku. Ma to duże znaczenie dla możliwości zwiększenia prędkości posuwu, szczególnie przy zakresie wysokości 1.0 m÷1.6 m. Przy wykorzystaniu znanych, z rozwiązań strugowych, systemów automatyki, sterowania i diagnostyki wprowadzenie automatyzacji procesu nie będzie stanowiło znaczącego problemu. W proponowanym rozwiązaniu kombajn ma możliwość wyjechania do chodnika na tyle, aby możliwe było zrealizowanie przekładki jak w przypadku strugów. Uzyskuje się wtedy krótki czas przekładki, który w skrajnym przypadku może zmieścić się w tzw. czasie organizacyjnym ściany. Ponadto urabianie odbywa się pełnym zabiorem na całej długości ściany co również korzystnie wpływa na wydobycie. Przekładkę realizować będą, oprócz układów przesuwnych sekcji, układy przesuwne napędów zlokalizowane w chodnikach lub ewentualnie obudowa skrzyżowań. Do sterowania położeniem kombajnu jednoorganowego, a w szczególności kierunkiem eksploatacji na wybiegu ściany (wznios, upad), zastosowane będą siłowniki korekcyjne łączące belkę układu przesuwnego sekcji z rynną przenośnika. Kopalnie jak i producenci sprzętu górniczego wykazują coraz większe zainteresowanie możliwością skutecznej eksploatacji pokładów cienki. Zaproponowany kompleks do eksploatacji cienkich pokładów wyposażony w kombajn jednoorganowy przeznaczony jest do pracy w technologii urabiania dwukierunkowego. Charakterystyczną cechą tej technologii jest brak fazy zawrębiania oraz praca na pełny zabiór na całej długości ściany. W przypadku zmiany grubości pokładu możliwa jest zmiana organu, natomiast sterowanie w kierunku wybiegu odbywać się będzie za pomocą siłowników korekcyjnych. Opracowanie technologii pracy kompleksu wyposażonego w kombajn jednoorganowy, analiza możliwego do osiągnięcia wydobycia dobowego, przy jego zastosowaniu oraz określenie wymaganych parametrów maszyn kompleksu ścianowego, a w szczególności kombajnu, potwierdza poprawność przyjętych założeń.

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