Balik Terrorism: The Return of the Abu Sayyaf

DTIC Science & Technology

2005-09-01

Hudaibiyah," to work with the ASG. The JI operative, Rohmat (aka Zaki), had been a JI trainer at Camp Hudaibiyah in Camp Abu Bakar in 2000, and then in...brothers traveled to Camp Abu Bakar in August 1999 to meet with MILF leaders; and in December 2001, Santos underwent military and explosives training...More Davao Bombers Nabbed in Davao Norte," Sun-Star, November 19, 2004. 68. Camp Hudaibiyah was the portion of the MILF base, Camp Abu Bakar es

Traditional production, consumption and storage of Kunu--a non alcoholic cereal beverage.

PubMed

Gaffa, T; Jideani, I A; Nkama, I

2002-01-01

A survey of the production, consumption and storage of Kunu was carried out. Some of the information included consumption rate, processing techniques and equipment, producer's status and grains used. About 73% consume Kunu daily, 26% occasionally; 1% know it is produced but may or may not be consuming it. Millet (Pennisetum typhoideum), sorghum (Sorghum vulgare), maize (Zea mays), rice (Oryza sativa) and acha (Digitalis exilis) were used in its production in decreasing order of preference. The grains were used singly or combined; sorghum/millet was the most common combination in a ratio of 1:2 (w/w). Steeping was done in ordinary water for 12-72 h, depending on the grain type, in local clay pots, plastic buckets, calabashes or basins or 5-7 h in warm water (60-70 degrees C). The grains were dry or wet milled with or without spices such as ginger, red pepper, black pepper, clove and garlic. Other ingredients introduced included: sweet potatoes, malted rice, malted sorghum and Cadaba farinosa crude extract. Both dry and wet milling was done with grinding mills, mill stones or mortar and pestle, depending on locality. The product was then cooked into a thin free flowing gruel. The various types of kunu were: Kunun zaki, Kunun gyada, Kunun akamu, Kunun tsamiya, Kunun baule, Kunun jiko, Amshau and Kunun gayamba. Kunun zaki was the most commonly consumed. Production and consumption cut across all social classes of the society.

Hantavirus Pulmonary Syndrome in Central Bolivia: Relationships Between Reservoir Hosts, Habitats, and Viral Genotypes

DTIC Science & Technology

2005-01-01

in Brazil. J Med Virol 59: 527–535. 7. Lopez N, Padula P, Rossi C, Lazaro ME, Franze-Fernandez MT, 1996. Genetic identification of a new hantavirus...177: 529–538. 10. Toro J, Vega JD, Khan AS, Mills JN, Padula P, Terry W, Yadon Z, Valderrama R, Ellis BA, Pavletic C, Cerda R, Zaki S, Wun- Ju S, Meyer...Chile, 1997. Emerg Infect Dis 4: 687–694. 11. Padula PJ, Rossi CM, Della Valle MO, Martinez PV, Colavecchia SB, Edelstein A, Miguel SD, Rabinovich RD

Integration and Validation of Avian Radars (IVAR)

DTIC Science & Technology

2011-08-01

hazards of electromagnetic radiation to fuel HERO hazards of electromagnetic radiation to ordnance HERP hazards ... hazard Radiation hazard to humans, fuels, and ordnance can be easily managed. Demonstration of how operation of radars can meet hazards of... electromagnetic radiation to personnel (HERP), hazards of electromagnetic radiation to

Mitigating the Tyranny, a Moral Responsibility

DTIC Science & Technology

2009-12-01

to their society they must be physically and emotionally equipped to handle life outside the warzone; it is, therefore, the military’s obligation...Moral Responsibilities of Victors in War, Warfare studies AY10 Coursebook , edited by Sharon McBride, (Maxwell AFB, Al: Air University Press, October... Coursebook , edited by Sharon McBride, page156-167. Maxwell AFB, AL [or Ala.]: Air University Press, October 2009. Myhr, Kjell-Ivar. ―Norsk F-16 pilot

Yamani

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robinson, J.

1988-01-01

In 1962, when oil was $2/bbl (*12.50/m/sup 3/), King Faisal appointed a lawyer as minister of petroleum. According to the author, he wrestled control of Saudi Arabia's oil away from the U.S. during the next 11 years and turned the OPEC cartel into a major world force. In Oct. 1973, when war broke out in the Middle East, this man held the world to ransom. Yet in 1989, a one-sentence edict brought his political career to an end. This book traces these events in a biographical account of the former Saudi Arabian oil minister and leading force behind OPEC, Sheikmore » Ahmed Zaki Yamani.« less

SSBRP Communication & Data System Development using the Unified Modeling Language (UML)

NASA Technical Reports Server (NTRS)

Windrem, May; Picinich, Lou; Givens, John J. (Technical Monitor)

1998-01-01

The Unified Modeling Language (UML) is the standard method for specifying, visualizing, and documenting the artifacts of an object-oriented system under development. UML is the unification of the object-oriented methods developed by Grady Booch and James Rumbaugh, and of the Use Case Model developed by Ivar Jacobson. This paper discusses the application of UML by the Communications and Data Systems (CDS) team to model the ground control and command of the Space Station Biological Research Project (SSBRP) User Operations Facility (UOF). UML is used to define the context of the system, the logical static structure, the life history of objects, and the interactions among objects.

Reactor pressure vessel embrittlement: Insights from neural network modelling

NASA Astrophysics Data System (ADS)

Mathew, J.; Parfitt, D.; Wilford, K.; Riddle, N.; Alamaniotis, M.; Chroneos, A.; Fitzpatrick, M. E.

2018-04-01

Irradiation embrittlement of steel pressure vessels is an important consideration for the operation of current and future light water nuclear reactors. In this study we employ an ensemble of artificial neural networks in order to provide predictions of the embrittlement using two literature datasets, one based on US surveillance data and the second from the IVAR experiment. We use these networks to examine trends with input variables and to assess various literature models including compositional effects and the role of flux and temperature. Overall, the networks agree with the existing literature models and we comment on their more general use in predicting irradiation embrittlement.

Resilience of a High Latitude Red Sea Frining Corals Exposed to Extreme Temperatures

NASA Astrophysics Data System (ADS)

Moustafa, M.; Moustafa, M. S.; Moustafa, S.; Moustafa, Z. D.

2013-05-01

Since 2004, multi-year study set out to establish linkages between fringing coral reefs in the northern Gulf of Suez, Red Sea, and local weather. Insight into local meteorological processes may provide a better understanding of the direct influence weather has on a fringing coral reef. To establish trends, seawater temperature and meteorological record were collected at a small fringing coral reef (Zaki's Reef), located near Ein Sokhna, Egypt (29.5oN & 32.4oE). Monitoring air and water temperature provides evidence of seasonality and interannual variability and may reveal correlations between reef health and climate conditions in this region. Prior to this study, there were no known long-term studies investigating coral reefs in this region. Approximately 35 coral taxa are known to survive the extreme temperature and salinity regime found here, yet only six corals compose 94% of coral cover on Zaki's Reef. Dominant corals include: Acropora humilis, A. microclados, A. hemprichii, Litophyton arboretum, Stylophora pistillata, Porites columna, and P. plantulata. Seawater temperatures were collected at 30 minutes intervals at 5 locations. Seawater temperature data indicate that corals experience 4-6.5oC daily temperature variations and seasonal variations that exceed 29oC. Air temperatures were collected just landward of the reef were compared to Hurghada and Ismailia 400 and 200 km south and north of the study site, respectively. Time series analysis results indicate that air temperature dominant frequencies are half-daily, daily, and yearly cycles, while water temperatures show yearly cycles. A comparison of air temperature with neighboring locations indicates that air temperatures at Ein Sokhna ranged between near 0o C to an excess of 55o C, yet, daily means for Ein Sokhna and Hurghada were very similar (24.2o C and. 25.2o C, respectively). Maximum daily air temperatures at the study site exceeded maximum air temperature at Hurghada (400 km south) by almost 7o C

Astrometric observations of comets and asteroids and subsequent orbital investigations

NASA Technical Reports Server (NTRS)

Mccrosky, R. E.; Marsden, B. G.

1986-01-01

During the past year some 500 observations were made on 66 nights and published on the MPCs (Minor Planet Circulars/Minor Planets and Comets). In addition, a handful of measurements of earlier plates were completed and published. 121 of the observations published referred to comets. Of special importance were observations of comets (P/Giacobini-Zinner and P/Halley) in connection with the NASA ICE and ESA Giotto missions, but a special effort was made to get good coverage of almost all of the observable comets. Observations were also made of (2060) Chiron and of the earth-approaching objects (1627) Ivar, (1866) Sisyphys, (1943) Anteros, (3362) 1984 QA, 1985 JA, PA, TB and WA, and 1986 DA and EB. 46 minor planets were given permanent numbers entirely as a result of the observations.

Iterative non-sequential protein structural alignment.

PubMed

Salem, Saeed; Zaki, Mohammed J; Bystroff, Christopher

2009-06-01

Structural similarity between proteins gives us insights into their evolutionary relationships when there is low sequence similarity. In this paper, we present a novel approach called SNAP for non-sequential pair-wise structural alignment. Starting from an initial alignment, our approach iterates over a two-step process consisting of a superposition step and an alignment step, until convergence. We propose a novel greedy algorithm to construct both sequential and non-sequential alignments. The quality of SNAP alignments were assessed by comparing against the manually curated reference alignments in the challenging SISY and RIPC datasets. Moreover, when applied to a dataset of 4410 protein pairs selected from the CATH database, SNAP produced longer alignments with lower rmsd than several state-of-the-art alignment methods. Classification of folds using SNAP alignments was both highly sensitive and highly selective. The SNAP software along with the datasets are available online at http://www.cs.rpi.edu/~zaki/software/SNAP.

Physical Characterization of Warm Spitzer-observed Near-Earth Objects

NASA Technical Reports Server (NTRS)

Thomas, Cristina A.; Emery, Joshua P.; Trilling, David E.; Delbo, Marco; Hora, Joseph L.; Mueller, Michael

2014-01-01

Near-infrared spectroscopy of Near-Earth Objects (NEOs) connects diagnostic spectral features to specific surface mineralogies. The combination of spectroscopy with albedos and diameters derived from thermal infrared observations can increase the scientific return beyond that of the individual datasets. For instance, some taxonomic classes can be separated into distinct compositional groupings with albedo and different mineralogies with similar albedos can be distinguished with spectroscopy. To that end, we have completed a spectroscopic observing campaign to complement the ExploreNEOs Warm Spitzer program that obtained albedos and diameters of nearly 600 NEOs (Trilling et al., 2010). The spectroscopy campaign included visible and near-infrared observations of ExploreNEOs targets from various observatories. Here we present the results of observations using the low-resolution prism mode (approx. 0.7-2.5 microns) of the SpeX instrument on the NASA Infrared Telescope Facility (IRTF). We also include near-infrared observations of Explore-NEOs targets from the MIT-UH-IRTF Joint Campaign for Spectral Reconnaissance. Our dataset includes near-infrared spectra of 187 ExploreNEOs targets (125 observations of 92 objects from our survey and 213 observations of 154 objects from the MIT survey). We identify a taxonomic class for each spectrum and use band parameter analysis to investigate the mineralogies for the S-, Q-, and V-complex objects. Our analysis suggests that for spectra that contain near-infrared data but lack the visible wavelength region, the Bus-DeMeo system misidentifies some S-types as Q-types. We find no correlation between spectral band parameters and ExploreNEOs albedos and diameters. We investigate the correlations of phase angle with band area ratio and near-infrared spectral slope. We find slightly negative Band Area Ratio (BAR) correlations with phase angle for Eros and Ivar, but a positive BAR correlation with phase angle for Ganymed.The results of our

Orbital evolution studies of planet-crossing asteroids.

NASA Astrophysics Data System (ADS)

Hahn, Gerhard; Lagerkvist, Claes-Ingvar

1987-03-01

Numerical integrations of 26 orbits of planet-crossing astetoids of Apollo-Amor type have been performed, in a solar system model including the perturbations by the planets from Venus to Neptune. The 15:th order RADAU integrator (Everhart, 1985) has been used. Orbits for the asteroids 433 Eros, 887 Alinda, 1036 Ganymed, 1221 Amor, 1580 Betulia, 1627 Ivar, 1685 Toro, 1862 Apollo, 1863 Antinous, 1864 Daedalus, 1865 Cerberus, 1915 Quetzalcoatl and 1916 Boreas have been integrated over 100 000 years forward in time and for 1866 Sisyphus, 2102 Tantalus, 2201 Oljato, 2329 Orthos, 3360 1981 VA, 3552 1983 SA, 1981 EJ30, 1985 PA, 1985 WA, 1986 DA 1986 JK and 1986 RA a period of about 33 000 years has been covered. The orbital evolutions of these asteroids are discussed. This work is part of a larger study of the long-term orbital evolution of planet-crossing asteroids and will be continued within the project SPACEGUARD (Milani et al., 1987).

A Physically Based Correlation of Irradiation-Induced Transition Temperature Shifts for RPV Steels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eason, Ernest D.; Odette, George Robert; Nanstad, Randy K

2007-11-01

surveillance data. It contains two terms, corresponding to the best-understood radiation damage features, matrix damage and copper-rich precipitates, although the empirical calibration will ensure that all other damage processes that are occurring are also reflected in those terms. Effects of material chemical composition, product form, and radiation exposure are incorporated, such that all effects are supported by findings of statistical significance, physical understanding, or comparison with independent data from controlled experiments, such as the Irradiation Variable (IVAR) Program. In most variable effects, the model is supported by two or three of these different forms of evidence. The key variable trends, such as the neutron fluence dependence and copper-nickel dependence in the new TTS model, are much improved over RG1.99/2 and are well supported by independent data and the current understanding of embrittlement mechanisms. The new model includes the variables copper, nickel, and fluence that are in RG1.99/2, but also includes effects of irradiation temperature, neutron flux, phosphorus, and manganese. The calibrated model is a good fit, with no significant residual error trends in any of the variables used in the model or several additional variables and variable interactions that were investigated. The report includes a chapter summarizing the current understanding of embrittlement mechanisms and one comparing the IVAR database with the TTS model predictions. Generally good agreement is found in that quantitative comparison, providing independent confirmation of the predictive capability of the TTS model. The key new insight in the TTS modeling effort, that flux effects are evident in both low (or no) copper and higher copper materials, is supported by the IVAR data. The slightly simplified version of the TTS model presented in Section 7.3 of this report is recommended for applications.« less

Physiology of Pseudomonas aeruginosa in biofilms as revealed by transcriptome analysis

PubMed Central

2010-01-01

Background Transcriptome analysis was applied to characterize the physiological activities of Pseudomonas aeruginosa grown for three days in drip-flow biofilm reactors. Conventional applications of transcriptional profiling often compare two paired data sets that differ in a single experimentally controlled variable. In contrast this study obtained the transcriptome of a single biofilm state, ranked transcript signals to make the priorities of the population manifest, and compared ranki ngs for a priori identified physiological marker genes between the biofilm and published data sets. Results Biofilms tolerated exposure to antibiotics, harbored steep oxygen concentration gradients, and exhibited stratified and heterogeneous spatial patterns of protein synthetic activity. Transcriptional profiling was performed and the signal intensity of each transcript was ranked to gain insight into the physiological state of the biofilm population. Similar rankings were obtained from data sets published in the GEO database http://www.ncbi.nlm.nih.gov/geo. By comparing the rank of genes selected as markers for particular physiological activities between the biofilm and comparator data sets, it was possible to infer qualitative features of the physiological state of the biofilm bacteria. These biofilms appeared, from their transcriptome, to be glucose nourished, iron replete, oxygen limited, and growing slowly or exhibiting stationary phase character. Genes associated with elaboration of type IV pili were strongly expressed in the biofilm. The biofilm population did not indicate oxidative stress, homoserine lactone mediated quorum sensing, or activation of efflux pumps. Using correlations with transcript ranks, the average specific growth rate of biofilm cells was estimated to be 0.08 h-1. Conclusions Collectively these data underscore the oxygen-limited, slow-growing nature of the biofilm population and are consistent with antimicrobial tolerance due to low metabolic activity

Understanding criminal behavior: Empathic impairment in criminal offenders.

PubMed

Mariano, Melania; Pino, Maria Chiara; Peretti, Sara; Valenti, Marco; Mazza, Monica

2017-08-01

Criminal offenders (CO) are characterized by antisocial and impulsive lifestyles and reduced empathy competence. According to Zaki and Ochsner, empathy is a process that can be divided into three components: mentalizing, emotional sharing and prosocial concern. The aim of our study was to evaluate these competences in 74 criminal subjects compared to 65 controls. The CO group demonstrated a lower ability in measures of mentalizing and sharing, especially in recognizing the mental and emotional states of other people by observing their eyes and sharing other people's emotions. Conversely, CO subjects showed better abilities in prosocial concern measures, such as judging and predicting the emotions and behavior of other people, but they were not able to evaluate the gravity of violations of social rules as well as the control group. In addition, logistic regression results show that the higher the deficits in the mentalizing component are, the higher the probability of committing a crime against another person. Taken together, our results suggest that criminal subjects are able to judge and recognize other people's behavior as right or wrong in a social context, but they are not able to recognize and share the suffering of other people.

Competing disturbance amplification mechanisms in two-fluid boundary layers

NASA Astrophysics Data System (ADS)

Saha, Sandeep; Page, Jacob; Zaki, Tamer

2015-11-01

The linear stability of boundary layers above a thin wall film of lower viscosity is analyzed. Appropriate choice of the film thickness and viscosity excludes the possibility of interfacial instabilities. Transient amplification of disturbances is therefore the relevant destabilizing influence, and can take place via three different mechanisms in the two-fluid configuration. Each is examined in detail by solving an initial value problem whose initial condition comprises a pair of appropriately chosen eigenmodes from the discrete, continuous and interface modes. Two regimes are driven by the lift-up mechanism: (i) The response to a streamwise vortex and (ii) the normal vorticity generated by a stable Tollmien-Schlichting wave. Both are damped due to the film. The third regime is associated with the wall-normal vorticity that is generated by the interface displacement. It can lead to appreciable streamwise velocity disturbances in the near-wall region at relatively low viscosity ratios. The results demonstrate that a wall film can stabilize the early linear stages of boundary-layer transition, and explain the observations from the recent nonlinear direct numerical simulations of this configuration by Jung & Zaki (J. Fluid Mech., vol 772, 2015, 330-360).

Physical characterization of Warm Spitzer-observed near-Earth objects

NASA Astrophysics Data System (ADS)

Thomas, Cristina A.; Emery, Joshua P.; Trilling, David E.; Delbó, Marco; Hora, Joseph L.; Mueller, Michael

2014-01-01

Near-infrared spectroscopy of Near-Earth Objects (NEOs) connects diagnostic spectral features to specific surface mineralogies. The combination of spectroscopy with albedos and diameters derived from thermal infrared observations can increase the scientific return beyond that of the individual datasets. For instance, some taxonomic classes can be separated into distinct compositional groupings with albedo and different mineralogies with similar albedos can be distinguished with spectroscopy. To that end, we have completed a spectroscopic observing campaign to complement the ExploreNEOs Warm Spitzer program that obtained albedos and diameters of nearly 600 NEOs (Trilling, D.E. et al. [2010]. Astron. J. 140, 770-784. http://dx.doi.org/10.1088/0004-6256/140/3/770). The spectroscopy campaign included visible and near-infrared observations of ExploreNEOs targets from various observatories. Here we present the results of observations using the low-resolution prism mode (˜0.7-2.5 μm) of the SpeX instrument on the NASA Infrared Telescope Facility (IRTF). We also include near-infrared observations of ExploreNEOs targets from the MIT-UH-IRTF Joint Campaign for Spectral Reconnaissance. Our dataset includes near-infrared spectra of 187 ExploreNEOs targets (125 observations of 92 objects from our survey and 213 observations of 154 objects from the MIT survey). We identify a taxonomic class for each spectrum and use band parameter analysis to investigate the mineralogies for the S-, Q-, and V-complex objects. Our analysis suggests that for spectra that contain near-infrared data but lack the visible wavelength region, the Bus-DeMeo system misidentifies some S-types as Q-types. We find no correlation between spectral band parameters and ExploreNEOs albedos and diameters. We investigate the correlations of phase angle with Band Area Ratio and near-infrared spectral slope. We find slightly negative Band Area Ratio (BAR) correlations with phase angle for Eros and Ivar, but a

Improving Drinking Water Quality by Remineralisation.

PubMed

Luptáková, Anna; Derco, Ján

2015-01-01

The reason of low mineral content in source water is its origin in poorly soluble mineral geological structures. There are many areas with very soft low-mineralised water around the world. All people involved in drinking water treatment as well as some public health experts and producers of chemicals used for water treatment may be interested in the study. Enrichment of drinking water by minerals including calcium and magnesium is very important particularly in regions where drinking water is prepared by desalination. The aim of this work was to study and intensify the recarbonization process. Half-calcined dolomite in combination with carbon dioxide constitutes the chemistry of the applied method. Advantages of using a fluidised bed reactor contributed also significantly to the process efficiency enhancement. Continuous input of carbon dioxide into the fluidised bed recarbonization reactor resulted in an increase in the recarbonization rate by about one order of magnitude compared with the process in without carbon dioxide addition. Very good fit of experimental data for hydrodynamic characteristics of fluidised bed was obtained using simple model based on the Richardson and Zaki expansion equation. The first order model describes kinetic data from the recarbonization process with a good accuracy. Higher recarbonization rates were observed with smaller particles of half-calcined dolomite.

Numerical simulation of pseudoelastic shape memory alloys using the large time increment method

NASA Astrophysics Data System (ADS)

Gu, Xiaojun; Zhang, Weihong; Zaki, Wael; Moumni, Ziad

2017-04-01

The paper presents a numerical implementation of the large time increment (LATIN) method for the simulation of shape memory alloys (SMAs) in the pseudoelastic range. The method was initially proposed as an alternative to the conventional incremental approach for the integration of nonlinear constitutive models. It is adapted here for the simulation of pseudoelastic SMA behavior using the Zaki-Moumni model and is shown to be especially useful in situations where the phase transformation process presents little or lack of hardening. In these situations, a slight stress variation in a load increment can result in large variations of strain and local state variables, which may lead to difficulties in numerical convergence. In contrast to the conventional incremental method, the LATIN method solve the global equilibrium and local consistency conditions sequentially for the entire loading path. The achieved solution must satisfy the conditions of static and kinematic admissibility and consistency simultaneously after several iterations. 3D numerical implementation is accomplished using an implicit algorithm and is then used for finite element simulation using the software Abaqus. Computational tests demonstrate the ability of this approach to simulate SMAs presenting flat phase transformation plateaus and subjected to complex loading cases, such as the quasi-static behavior of a stent structure. Some numerical results are contrasted to those obtained using step-by-step incremental integration.

Microstructural growth increments in the brachiopods Liothyrella uva and L. neozelanica: preliminary study of growth analysis and proxy calibration

NASA Astrophysics Data System (ADS)

Romanin, Marco; Aleksandra Bitner, Maria; Brand, Uwe

2017-04-01

Brachiopods secrete low-Mg calcite shells in near equilibrium with the surrounding sea water, with respect to their secondary and tertiary layers. For this reason, in recent years they have been intensively studied as archives for oceanographic and environmental proxies. The primary layer has been shown not to be deposited in equilibrium with the ambient sea water, leading to a novel cleaning protocol proposed by Zaki et al (2015). In the spite of improving on existing proxies, the shell microstructure and growth has to be taken in to account in their applications. The secretion of the primary layer is known to be external of the shell, but in SEM investigations of Liothyrella uva and L. neozelanica we discovered that the primary layer has its origin within the fibres of the secondary layer. Furthermore, the primary layer calcite is not a continuum but instead it consists of a 'new' band for each major growth increment. There is overlap between the preceding and subsequent 'band' (or shingles) of the primary layer, which may extend into the secondary/tertiary layer. This finding may lead to more comprehensive knowledge of shell microstructure processes in L. uva and L. neozelanica that may be applied and extended to other modern and fossil brachiopods, including age dating of brachiopods. This discovery may make brachiopod archives more reliable and consistent proxies when applied to and interpreting their geological record.

The method of planes pressure tensor for a spherical subvolume

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heyes, D. M., E-mail: d.heyes@imperial.ac.uk; Smith, E. R., E-mail: edward.smith05@imperial.ac.uk; Dini, D., E-mail: d.dini@imperial.ac.uk

2014-02-07

Various formulas for the local pressure tensor based on a spherical subvolume of radius, R, are considered. An extension of the Method of Planes (MOP) formula of Todd et al. [Phys. Rev. E 52, 1627 (1995)] for a spherical geometry is derived using the recently proposed Control Volume formulation [E. R. Smith, D. M. Heyes, D. Dini, and T. A. Zaki, Phys. Rev. E 85, 056705 (2012)]. The MOP formula for the purely radial component of the pressure tensor is shown to be mathematically identical to the Radial Irving-Kirkwood formula. Novel offdiagonal elements which are important for momentum conservation emergemore » naturally from this treatment. The local pressure tensor formulas for a plane are shown to be the large radius limits of those for spherical surfaces. The radial-dependence of the pressure tensor computed by Molecular Dynamics simulation is reported for virtual spheres in a model bulk liquid where the sphere is positioned randomly or whose center is also that of a molecule in the liquid. The probability distributions of angles relating to pairs of atoms which cross the surface of the sphere, and the center of the sphere, are presented as a function of R. The variance in the shear stress calculated from the spherical Volume Averaging method is shown to converge slowly to the limiting values with increasing radius, and to be a strong function of the number of molecules in the simulation cell.« less

What is a global manager?

PubMed

Bartlett, C A; Ghoshal, S

1992-01-01

To compete around the world, a company needs three strategic capabilities: global-scale efficiency, local responsiveness, and the ability to leverage learning worldwide. No single "global" manager can build these capabilities. Rather, groups of specialized managers must integrate assets, resources, and people in diverse operating units. Such managers are made, not born. And how to make them is--and must be--the foremost question for corporate managers. Drawing on their research with leading transnational corporations, Christopher Bartlett and Sumantra Ghoshal identify three types of global managers. They also illustrate the responsibilities each position involves through a close look at the careers of successful executives: Leif Johansson of Electrolux, Howard Gottlieb of NEC, and Wahib Zaki of Procter & Gamble. The first type is the global business or product-division manager who must build worldwide efficiency and competitiveness. These managers recognize cross-border opportunities and risks as well as link activities and capabilities around the world. The second is the country manager whose unit is the building block for worldwide operations. These managers are responsible for understanding and interpreting local markets, building local resources and capabilities, and contributing to--and participating in--the development of global strategy. Finally, there are worldwide functional specialists--the managers whose potential is least appreciated in many traditional multinational companies. To transfer expertise from one unit to another and leverage learning, these managers must scan the company for good ideas and best practice, cross-pollinate among units, and champion innovations with worldwide applications.

The effects of diseases, drugs, and chemicals on the creativity and productivity of famous sculptors, classic painters, classic music composers, and authors.

PubMed

Wolf, Paul L

2005-11-01

Many myths, theories, and speculations exist as to the exact etiology of the diseases, drugs, and chemicals that affected the creativity and productivity of famous sculptors, classic painters, classic music composers, and authors. To emphasize the importance of a modern clinical chemistry laboratory and hematology coagulation laboratory in interpreting the basis for the creativity and productivity of various artists. This investigation analyzed the lives of famous artists, including classical sculptor Benvenuto Cellini; classical sculptor and painter Michelangelo Buonarroti; classic painters Ivar Arosenius, Edvard Munch, and Vincent Van Gogh; classic music composer Louis Hector Berlioz; and English essayist Thomas De Quincey. The analysis includes their illnesses, their famous artistic works, and the modern clinical chemistry, toxicology, and hematology coagulation tests that would have been important in the diagnosis and treatment of their diseases. The associations between illness and art may be close and many because of both the actual physical limitations of the artists and their mental adaptation to disease. Although they were ill, many continued to be productive. If modern clinical chemistry, toxicology, and hematology coagulation laboratories had existed during the lifetimes of these various well-known individuals, clinical laboratories might have unraveled the mysteries of their afflictions. The illnesses these people endured probably could have been ascertained and perhaps treated. Diseases, drugs, and chemicals may have influenced their creativity and productivity.

From X-Rays to MRI: Physics in GE

NASA Astrophysics Data System (ADS)

Schmitt, Roland W.

2004-03-01

The GE Research Laboratory, founded in 1900, became the first laboratory of scientific research in U.S. industry. William Coolidge, a physicist, joined the laboratory in 1905 and produced two advances of immense importance. The first, ductile tungsten, is still the heart of every incandescent light bulb. The second, the "Coolidge" X-Ray tube, remains an essential tool of modern medicine. In the process, Coolidge explored two main approaches of physics in industry. One addresses a commercial problem or opportunity (better light bulbs) and finds interesting physics. The other explores interesting physics (X-rays) and creates a commercial opportunity. This paper addresses the mix of these approaches during GE's years as an "electric" (and therefore physics-based) company. Episodes include the following: the work of Irving Langmuir (1932 Nobel laureate in chemistry, but as much physicist as chemist); the post-World War II "golden age of industrial physics" when the endless frontier offered opportunities from nuclear power to diamond making to superconductivity; the Nobel-prize winning work of Ivar Giaever; and interdisciplinary efforts that enabled GE to become a world business leader in two medical diagnostic technologies it did not invent: computed tomography and magnetic resonance imaging. I will speculate on whether this mix of problem-driven and opportunity-driven effort is as relevant to the 21st century as it was to the 20th.

The Use of "Literary Fiction" to Promote Mentalizing Ability.

PubMed

Pino, Maria Chiara; Mazza, Monica

2016-01-01

Empathy is a multidimensional process that incorporates both mentalizing and emotional sharing dimensions. Empathic competencies are important for creating interpersonal relationships with other people and developing adequate social behaviour. The lack of these social components also leads to isolation and exclusion in healthy populations. However, few studies have investigated how to improve these social skills. In a recent study, Kidd and Castano (2013) found that reading literary fiction increases mentalizing ability and may change how people think about other people's emotions and mental states. The aim of our study was to evaluate the effects of reading literary fiction, compared to nonfiction and science fiction, on empathic abilities. Compared to previous studies, we used a larger variety of empathy measures and utilized a pre and post-test design. In all, 214 healthy participants were randomly assigned to read a book representative of one of three literary genres (literary fiction, nonfiction, science fiction). Participants were assessed before and after the reading phase using mentalizing and emotional sharing tests, according to Zaki and Ochsner' s (2012) model. Comparisons of sociodemographic, mentalizing, and emotional sharing variables across conditions were conducted using ANOVA. Our results showed that after the reading phase, the literary fiction group showed improvement in mentalizing abilities, but there was no discernible effect on emotional sharing abilities. Our study showed that the reading processes can promote mentalizing abilities. These results may set important goals for future low-cost rehabilitation protocols for several disorders in which the mentalizing deficit is considered central to the disease, such as Autism Spectrum Disorders and Schizophrenia.

The Use of “Literary Fiction” to Promote Mentalizing Ability

PubMed Central

Mazza, Monica

2016-01-01

Empathy is a multidimensional process that incorporates both mentalizing and emotional sharing dimensions. Empathic competencies are important for creating interpersonal relationships with other people and developing adequate social behaviour. The lack of these social components also leads to isolation and exclusion in healthy populations. However, few studies have investigated how to improve these social skills. In a recent study, Kidd and Castano (2013) found that reading literary fiction increases mentalizing ability and may change how people think about other people’s emotions and mental states. The aim of our study was to evaluate the effects of reading literary fiction, compared to nonfiction and science fiction, on empathic abilities. Compared to previous studies, we used a larger variety of empathy measures and utilized a pre and post-test design. In all, 214 healthy participants were randomly assigned to read a book representative of one of three literary genres (literary fiction, nonfiction, science fiction). Participants were assessed before and after the reading phase using mentalizing and emotional sharing tests, according to Zaki and Ochsner’ s (2012) model. Comparisons of sociodemographic, mentalizing, and emotional sharing variables across conditions were conducted using ANOVA. Our results showed that after the reading phase, the literary fiction group showed improvement in mentalizing abilities, but there was no discernible effect on emotional sharing abilities. Our study showed that the reading processes can promote mentalizing abilities. These results may set important goals for future low-cost rehabilitation protocols for several disorders in which the mentalizing deficit is considered central to the disease, such as Autism Spectrum Disorders and Schizophrenia. PMID:27490164

A Modification and Analysis of Lagrangian Trajectory Modeling and Granular Dynamics of Lunar Dust Particles

NASA Technical Reports Server (NTRS)

Long, Jason M.; Lane, John E.; Metzger, Philip T.

2008-01-01

A previously developed mathematical model is amended to more accurately incorporate the effects of lift and drag on single dust particles in order to predict their behavior in the wake of high velocity gas flow. The model utilizes output from a CFD or DSMC simulation of exhaust from a rocket nozzle hot gas jet. An extension of the Saffman equation for lift based on the research of McLaughlin (1991) and Mei (1992) is used, while an equation for the Magnus force modeled after the work of Oesterle (1994) and Tsuji et al (1985) is applied. A relationship for drag utilizing a particle shape factor (phi = 0.8) is taken from the work of Haider and Levenspiel (1989) for application to non-spherical particle dynamics. The drag equation is further adjusted to account for rarefaction and compressibility effects in rarefied and high Mach number flows according to the work of Davies (1945) and Loth (2007) respectively. Simulations using a more accurate model with the correction factor (Epsilon = 0.8 in a 20% particle concentration gas flow) given by Richardson and Zaki (1954) and Rowe (1961) show that particles have lower ejection angles than those that were previously calculated. This is more prevalent in smaller particles, which are shown through velocity and trajectory comparison to be more influenced by the flow of the surrounding gas. It is shown that particles are more affected by minor changes to drag forces than larger adjustments to lift forces, demanding a closer analysis of the shape and behavior of lunar dust particles and the composition of the surrounding gas flow.

What is a global manager?

PubMed

Bartlett, Christopher A; Ghoshal, Sumantra

2003-08-01

Riven by ideology, religion, and mistrust, the world seems more fragmented than at any time since, arguably, World War II. But however deep the political divisions, business operations continue to span the globe, and executives still have to figure out how to run them efficiently and well. In "What Is a Global Manager?" (first published in September-October 1992), business professors Christopher Bartlett and Sumantra Ghoshal lay out a model for a management structure that balances the local, regional, and global demands placed on companies operating across the world's many borders. In the volatile world of transnational corporations, there is no such thing as a "universal" global manager, the authors say. Rather, there are three groups of specialists: business managers, country managers, and functional managers. And there are the top executives at corporate headquarters who manage the complex interactions between the three--and can identify and develop the talented executives a successful transnational requires. This kind of organizational structure characterizes a transnational rather than an old-line multinational, international, or global company. Transnationals integrate assets, resources, and diverse people in operating units around the world. Through a flexible management process, in which business, country, and functional managers form a triad of different perspectives that balance one another, transnational companies can build three strategic capabilities: global-scale efficiency and competitiveness; national-level responsiveness and flexibility; and cross-market capacity to leverage learning on a worldwide basis. Through a close look at the successful careers of Leif Johansson of Electrolux, Howard Gottlieb of NEC, and Wahib Zaki of Procter & Gamble, the authors illustrate the skills that each managerial specialist requires.

Capture of a recombinant protein from unclarified canola extract using streamline expanded bed anion exchange.

PubMed

Bai, Yun; Glatz, Charles E

2003-03-30

The feasibility of applying expanded bed adsorption technology to recombinant protein recovery from extracts of transgenic canola (rapeseed) was assessed. The extraction step results in a suspension of high solids content that is difficult to clarify. The coarse portion of the solids can be removed easily, and our aim was to operate the expanded bed in the presence of the recalcitrant particulates. Recombinant beta-glucuronidase (rGUS) produced in transgenic canola seed was the model system. Diethylaminoethyl (DEAE) and Streamline DEAE resin exhibited similar binding and elution properties for both rGUS and native canola proteins. More than 95% of native canola proteins did not bind to DEAE resins at pH 7.5, whereas the bound proteins were fractionated by two-step salt elution into two groups with the first peak, containing 70% of total bound proteins, at 20 mS/cm, followed by elution of rGUS at 50 mS/cm. The adsorption isotherm was only slightly influenced by the presence of up to 14 mg solids/mL extract; C(m) and K(d) changed by -1% and +39%, respectively. Bed expansion was semiquantitatively predictable from physical properties of the fluid together with Stokes's law and the Richardson-Zaki correlation for both clarified and partially clarified extracts. The presence of 1.4% solids did not change rGUS breakthrough behavior of the expanded bed; however, a small difference between expanded bed and packed bed was observed early in the sample loading stage, during which bed expansion adjusts. Canola solids moved through the column in approximately plug flow with no detriment to bed stability. Seventy-two percent recovery of 34-fold purified rGUS was obtained after initial loading of 1.4% (w/w) solids extract to 25% breakthrough. Copyright 2003 Wiley Periodicals, Inc. Biotechnol Bioeng 81: 855-864, 2003.

A novel NMDA receptor glycine-site partial agonist, GLYX-13, has therapeutic potential for the treatment of autism.

PubMed

Moskal, Joseph R; Burgdorf, Jeffrey; Kroes, Roger A; Brudzynski, Stefan M; Panksepp, Jaak

2011-10-01

Deficits in social approach behavior, rough-and-tumble play, and speech abnormalities are core features of autism that can be modeled in laboratory rats. Human twin studies show that autism has a strong genetic component, and a recent review has identified 99 genes that are dysregulated in human autism. Bioinformatic analysis of these 99 genes identified the NMDA receptor complex as a significant interaction hub based on protein-protein interactions. The NMDA receptor glycine site partial agonist d-cycloserine has been shown to treat the core symptom of social withdrawal in autistic children. Here, we show that rats selectively bred for low rates of play-induced pro-social ultrasonic vocalizations (USVs) can be used to model certain core symptoms of autism. Low-line animals engage in less social contact time with conspecifics, show lower rates of play induced pro-social USVs, and show an increased proportion of non-frequency modulated (i.e. monotonous) ultrasonic vocalizations, compared to non-selectively bred random-line animals. Gene expression patterns in the low-line animals show significant enrichment in autism-associated genes and the NMDA receptor family was identified as a significant hub. Treatment of low-line animals with the NMDAR glycine site partial agonist GLYX-13 rescued the deficits in play-induced pro-social 50-kHz and reduced monotonous USVs. Thus, the NMDA receptor has been shown to play a functional role in autism, and GLYX-13 shows promise for the treatment of autism. We dedicate this paper to Ole Ivar Lovaas (May 8, 1927-August 2, 2010), a pioneer in the field of autism. Copyright © 2011 Elsevier Ltd. All rights reserved.

VARS-TOOL: A Comprehensive, Efficient, and Robust Sensitivity Analysis Toolbox

NASA Astrophysics Data System (ADS)

Razavi, S.; Sheikholeslami, R.; Haghnegahdar, A.; Esfahbod, B.

2016-12-01

VARS-TOOL is an advanced sensitivity and uncertainty analysis toolbox, applicable to the full range of computer simulation models, including Earth and Environmental Systems Models (EESMs). The toolbox was developed originally around VARS (Variogram Analysis of Response Surfaces), which is a general framework for Global Sensitivity Analysis (GSA) that utilizes the variogram/covariogram concept to characterize the full spectrum of sensitivity-related information, thereby providing a comprehensive set of "global" sensitivity metrics with minimal computational cost. VARS-TOOL is unique in that, with a single sample set (set of simulation model runs), it generates simultaneously three philosophically different families of global sensitivity metrics, including (1) variogram-based metrics called IVARS (Integrated Variogram Across a Range of Scales - VARS approach), (2) variance-based total-order effects (Sobol approach), and (3) derivative-based elementary effects (Morris approach). VARS-TOOL is also enabled with two novel features; the first one being a sequential sampling algorithm, called Progressive Latin Hypercube Sampling (PLHS), which allows progressively increasing the sample size for GSA while maintaining the required sample distributional properties. The second feature is a "grouping strategy" that adaptively groups the model parameters based on their sensitivity or functioning to maximize the reliability of GSA results. These features in conjunction with bootstrapping enable the user to monitor the stability, robustness, and convergence of GSA with the increase in sample size for any given case study. VARS-TOOL has been shown to achieve robust and stable results within 1-2 orders of magnitude smaller sample sizes (fewer model runs) than alternative tools. VARS-TOOL, available in MATLAB and Python, is under continuous development and new capabilities and features are forthcoming.

The Contribution of Soil Moisture Information to Forecast Skill: Two Studies

NASA Technical Reports Server (NTRS)

Koster, Randal

2010-01-01

This talk briefly describes two recent studies on the impact of soil moisture information on hydrological and meteorological prediction. While the studies utilize soil moisture derived from the integration of large-scale land surface models with observations-based meteorological data, the results directly illustrate the potential usefulness of satellite-derived soil moisture information (e.g., from SMOS and SMAP) for applications in prediction. The first study, the GEWEX- and ClIVAR-sponsored GLACE-2 project, quantifies the contribution of realistic soil moisture initialization to skill in subseasonal forecasts of precipitation and air temperature (out to two months). The multi-model study shows that soil moisture information does indeed contribute skill to the forecasts, particularly for air temperature, and particularly when the initial local soil moisture anomaly is large. Furthermore, the skill contributions tend to be larger where the soil moisture initialization is more accurate, as measured by the density of the observational network contributing to the initialization. The second study focuses on streamflow prediction. The relative contributions of snow and soil moisture initialization to skill in streamflow prediction at seasonal lead, in the absence of knowledge of meteorological anomalies during the forecast period, were quantified with several land surface models using uniquely designed numerical experiments and naturalized streamflow data covering mUltiple decades over the western United States. In several basins, accurate soil moisture initialization is found to contribute significant levels of predictive skill. Depending on the date of forecast issue, the contributions can be significant out to leads of six months. Both studies suggest that improvements in soil moisture initialization would lead to increases in predictive skill. The relevance of SMOS and SMAP satellite-based soil moisture information to prediction are discussed in the context of these

Online Self-Administered Cognitive Testing Using the Amsterdam Cognition Scan: Establishing Psychometric Properties and Normative Data.

PubMed

Feenstra, Heleen Em; Vermeulen, Ivar E; Murre, Jaap Mj; Schagen, Sanne B

2018-05-30

Online tests enable efficient self-administered assessments and consequently facilitate large-scale data collection for many fields of research. The Amsterdam Cognition Scan is a new online neuropsychological test battery that measures a broad variety of cognitive functions. The aims of this study were to evaluate the psychometric properties of the Amsterdam Cognition Scan and to establish regression-based normative data. The Amsterdam Cognition Scan was self-administrated twice from home-with an interval of 6 weeks-by 248 healthy Dutch-speaking adults aged 18 to 81 years. Test-retest reliability was moderate to high and comparable with that of equivalent traditional tests (intraclass correlation coefficients: .45 to .80; .83 for the Amsterdam Cognition Scan total score). Multiple regression analyses indicated that (1) participants' age negatively influenced all (12) cognitive measures, (2) gender was associated with performance on six measures, and (3) education level was positively associated with performance on four measures. In addition, we observed influences of tested computer skills and of self-reported amount of computer use on cognitive performance. Demographic characteristics that proved to influence Amsterdam Cognition Scan test performance were included in regression-based predictive formulas to establish demographically adjusted normative data. Initial results from a healthy adult sample indicate that the Amsterdam Cognition Scan has high usability and can give reliable measures of various generic cognitive ability areas. For future use, the influence of computer skills and experience should be further studied, and for repeated measurements, computer configuration should be consistent. The reported normative data allow for initial interpretation of Amsterdam Cognition Scan performances. ©Heleen EM Feenstra, Ivar E Vermeulen, Jaap MJ Murre, Sanne B Schagen. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 30.05.2018.

Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin.

PubMed

Barnard, Dale L; Day, Craig W; Bailey, Kevin; Heiner, Matthew; Montgomery, Robert; Lauridsen, Larry; Winslow, Scott; Hoopes, Justin; Li, Joseph K-K; Lee, Jongdae; Carson, Dennis A; Cottam, Howard B; Sidwell, Robert W

2006-08-01

Because of the conflicting data concerning the SARS-CoV inhibitory efficacy of ribavirin, an inosine monophosphate (IMP) dehydrogenase inhibitor, studies were done to evaluate the efficacy of ribavirin and other IMP dehydrogenase inhibitors (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR), mizoribine, and mycophenolic acid) in preventing viral replication in the lungs of BALB/c mice, a replication model for severe acute respiratory syndrome (SARS) infections (Subbarao, K., McAuliffe, J., Vogel, L., Fahle, G., Fischer, S., Tatti, K., Packard, M., Shieh, W.J., Zaki, S., Murphy, B., 2004. Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus (SARS-CoV) in the respiratory tract of mice. J. Virol. 78, 3572-3577). Ribavirin given at 75 mg/kg 4 h prior to virus exposure and then given twice daily for 3 days beginning at day 0 was found to increase virus lung titers and extend the length of time that virus could be detected in the lungs of mice. Other IMP dehydrogenase inhibitors administered near maximum tolerated doses using the same dosing regimen as for ribavirin were found to slightly enhance virus replication in the lungs. In addition, ribavirin treatment seemed also to promote the production of pro-inflammatory cytokines 4 days after cessation of treatment, although after 3 days of treatment ribavirin inhibited pro-inflammatory cytokine production in infected mice, significantly reducing the levels of the cytokines IL-1alpha, interleukin-5 (IL-5), monocyte chemotactic protein-1 (MCP-1), and granulocyte-macrophage colony stimulating factor (GM-CSF). These findings suggest that ribavirin may actually contribute to the pathogenesis of SARS-CoV by prolonging and/or enhancing viral replication in the lungs. By not inhibiting viral replication in the lungs of infected mice, ribavirin treatment may have provided a continual source of stimulation for the inflammatory response

Computerized Decision Aids for Shared Decision Making in Serious Illness: Systematic Review.

PubMed

Staszewska, Anna; Zaki, Pearl; Lee, Joon

2017-10-06

illness. ©Anna Staszewska, Pearl Zaki, Joon Lee. Originally published in JMIR Medical Informatics (http://medinform.jmir.org), 06.10.2017.

A study of the 21 March 2012 tornadic quasi linear convective system in Catalonia

NASA Astrophysics Data System (ADS)

Bech, Joan; Arús, Joan; Castán, Salvador; Pineda, Nicolau; Rigo, Tomeu; Montanyà, Joan; van der Velde, Oscar

2015-05-01

This study presents a description of a quasi linear convective system that took place in Catalonia (NE Spain) on 21 March 2012 producing heavy rainfall, moderate lightning activity and a weak tornado in the village of Ivars d'Urgell around 19 UTC after local sunset. A post-event survey indicated EF0 and EF1 damage in houses of the village - roofs and ceilings, broken windows, fences and walls and trees knocked down - along a track approximately 4 km long and about 20 m wide. Doppler radar observations show that the parent thunderstorm that spawned the tornado was one of a series that developed along a convective line that moved from S to N, initiating convective activity in terms of precipitation and lightning in the Mediterranean Sea and moving inland in S Catalonia (Tarragona and Salou coastal areas, producing local flash floods). Convective activity remained several hours with series of thunderstorms developing along the same paths. The synoptic situation was dominated by a high pressure ridge extending from northern Africa to central Europe, with a closed maximum sea level pressure area around 1036 hPa over northern France, southern Germany and Austria. On the other hand a relative low pressure area seen on 850 hPa and upper levels was present over the Iberian Peninsula, favouring a southern maritime flow from the Mediterranean between the forward part of the low pressure area and the high pressure system which blocked the advance of the low to the east. In the study we examine both the synoptic environment and storm scale observations with Doppler radar and total lightning data (cloud to ground and intracloud flashes) that lead to this cool-season severe convective event which is remarkable given the fact that, unlike in this case, most reported tornadoes in the region occur during the warm season (with peaks in August and September) and during daylight hours (6 to 18 UTC).

Balloon Angioplasty – The Legacy of Andreas Grüntzig, M.D. (1939–1985)

PubMed Central

Barton, Matthias; Grüntzig, Johannes; Husmann, Marc; Rösch, Josef

2014-01-01

In 1974, at the Medical Policlinic of the University of Zürich, German-born physician-scientist Andreas Grüntzig (1939–1985) for the first time applied a balloon-tipped catheter to re-open a severely stenosed femoral artery, a procedure, which he initially called “percutaneous transluminal dilatation”. Balloon angioplasty as a therapy of atherosclerotic vascular disease, for which Grüntzig and Charles T. Dotter (1920–1985) received a nomination for the Nobel Prize in Physiology or Medicine in 1978, became one of the most successful examples of translational medicine in the twentieth century. Known today as percutaneous transluminal angioplasty (PTA) in peripheral arteries or percutaneous transluminal coronary angioplasty (PTCA) or percutaneous coronary intervention (PCI) in coronary arteries, balloon angioplasty has become the method of choice to treat patients with acute myocardial infarction or occluded leg arteries. On the occasion of the 40th anniversary of balloon angioplasty, we summarize Grüntzig’s life and career in Germany, Switzerland, and the United States and also review the developments in vascular medicine from the 1890s to the 1980s, including Dotter’s first accidental angioplasty in 1963. The work of pioneers of catheterization, including Pedro L. Fariñas in Cuba, André F. Cournand in France, Werner Forssmann, Werner Porstmann and Eberhard Zeitler in Germany, António Egas Moniz and Reynaldo dos Santos in Portugal, Sven-Ivar Seldinger in Sweden, and Barney Brooks, Thomas J. Fogarty, Melvin P. Judkins, Richard K. Myler, Dickinson W. Richards, and F. Mason Sones in the United States, is discussed. We also present quotes by Grüntzig and excerpts from his unfinished autobiography, statements of Grüntzig’s former colleagues and contemporary witnesses, and have included hitherto unpublished historic photographs and links to archive recordings and historic materials. This year, on June 25, 2014, Andreas Grüntzig would have celebrated

[Brief history of interventional radiology].

PubMed

Tang, Zhenliang; Jia, Aiqin; Li, Luoyun; Li, Chunyu

2014-05-01

In 1923, angiography was first successively used for the human body. In 1953, a Swedish doctor Sven-Ivar Seldinger pioneered the Seldinger technique, which laid down the foundation of interventional radiology. In 1963, Charles Dotter first proposed the idea of interventional radiology. In 1964, Charles Dotter opened a new era of percutaneous angioplasty through accidental operation, marking the formation of interventional radiology. On this basis, the techniques of balloon catheter dilation and metal stent implantation was developed. Endovascular stent was proposed in 1969. In 1973, the percutaneous angioplasty has been a breakthrough with the emergence of soft double-lumen balloon catheter. Percutaneous coronary angioplasty is applied in 1977. Since the 1990s, balloon angioplasty relegated to secondary status with the emergence of metal stent. Currently, endovascular stent have entered a new stage with the emergence of temporary stent and stent grafts and biological stent. Transcatheter arterial embolization had been one of the most important basic techniques for interventional radiology since 1965, it had also been a corresponding development with the improvement of embolic agents and catheter technology for the treatment of diseases now. Transjugular intrahepatic portosystemic stent-shunt is a comprehensive interventional radiology technology since 1967, in which the biliary system can be reached through a jugular vein, and the improvement appeared with balloon expandable stent in 1986.Since 1972, non-vascular interventional techniques was another important branch of interventional radiology. Currently, it is applied in the diagnosis and treatment of many diseases of the internal organs like the pancreas, liver, kidney, spinal cord, Fallopian tubes, esophagus and other organs. In 1973, Chinese radiologist first conducted the angiography test. Interventional radiology was introduced into China in the 1980s, it was readily developed through the sponsoring of

The Middle East Respiratory Syndrome Coronavirus - A Continuing Risk to Global Health Security.

PubMed

Azhar, Esam I; Lanini, Simone; Ippolito, Giuseppe; Zumla, Alimuddin

2017-01-01

Two new zoonotic coronaviruses causing disease in humans (Zumla et al. 2015a; Hui and Zumla 2015; Peiris et al. 2003; Yu et al. 2014) have been the focus of international attention for the past 14 years due to their epidemic potential; (1) The Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) (Peiris et al. 2003) first discovered in China in 2001 caused a major global epidemic of the Severe Acute Respiratory Syndrome (SARS). (2) The Middle East respiratory syndrome coronavirus (MERS-CoV) is a new corona virus isolated for the first time in a patients who died of severe lower respiratory tract infection in Jeddah (Saudi Arabia) in June 2012 (Zaki et al. 2012). The disease has been named Middle East Respiratory Syndrome (MERS) and it has remained on the radar of global public health authorities because of recurrent nosocomial and community outbreaks, and its association with severe disease and high mortality rates (Assiri et al. 2013a; Al-Abdallat et al. 2014; Memish et al. 2013a; Oboho et al. 2015; The WHO MERS-CoV Research Group 2013; Cotten et al. 2013a; Assiri et al. 2013b; Memish et al. 2013b; Azhar et al. 2014; Kim et al. 2015; Wang et al. 2015; Hui et al. 2015a). Cases of MERS have been reported from all continents and have been linked with travel to the Middle East (Hui et al. 2015a; WHO 2015c). The World Health Organization (WHO) have held nine meetings of the Emergency Committee (EC) convened by the Director-General under the International Health Regulations (IHR 2005) regarding MERS-CoV (WHO 2015c). There is wishful anticipation in the political and scientific communities that MERS-CoV like SARS-CoV will disappear with time. However it's been nearly 4 years since the first discovery of MERS-CoV, and MERS cases continue to be reported throughout the year from the Middle East (WHO 2015c). There is a large MERS-CoV camel reservoir, and there is no specific treatment or vaccine (Zumla et al. 2015a). With 10 million people visiting Saudi Arabia every

Committee for International Conference on Mechanical Engineering Research (ICMER 2011)

NASA Astrophysics Data System (ADS)

Yusoff, Ahmad Razlan Bin

2012-09-01

Special Task & Poster 1) Lee Giok Chui (Chair) 2) Mohd Fadzil Abdul Rahim 3) Che Ku Eddy Nizwan 4) Hazami Che Hussain 5) Mohd Fazli Ismail 6) Mahdhir Mohd Yusof 7) Mohd Padzly Radzi 8) Rahimah Che Ramli Secretariats 1) Ir. Ahmad Rasdan Ismail (Chair) 2) Mohd Shahri Mohd Akhir 3) Luqman Hakim Ahmad Shah 4) Juliawati Alias 5) Nurazima Ismail 6) Mohamad Faizal Mohamed Zahri 7) Raja Allen Jordan Izzuddin Shah 8) Rosidah Mohd Norsat 9) Norshalawati Mat Yusof 10) Zainab Daud 11) Nur Sufiah Jamaludin 12) Azslinda Ibrahim 13) Nurul Azreen Zainal Abidin 14) Nurul Ashikin Mohd Khalil 15) Mohd Zaki Mohd Ali

Synchrotron X-ray Scattering from Self-organized Soft Nanostructures in Clays

NASA Astrophysics Data System (ADS)

Fossum, J. O.

2009-04-01

. Gog, C. Venkataraman, Observations of orientational ordering in aqueous suspensions of a nano-layered silicate, ENERGY The International Journal 30, 873 (2005). 2. D. M. Fonseca, Y. Méheust, J. O. Fossum, K. D. Knudsen, K. J. Måløy and K. P. S. Parmar, Phase behavior of platelet-shaped nanosilicate colloids in saline solutions: A small-angle X-ray scattering study J. Appl. Cryst. 40 292 (2007) 3. E. N. de Azevedo, M. Engelsberg, J. O. Fossum, R. E. de Souza, Anisotropic water diffusion in nematic self-assemblies of clay nano-platelets suspended in water, Langmuir 23, 5100 (2007) 4. Nils Ivar Ringdal, Master thesis, Department of Physics, NTNU (2008) 5. J.O. Fossum, Y. Meheust, K.P.S. Parmar, K.D. Knudsen, K.J. Maloy, D.d.M. Fonseca, Intercalation-enhanced electric polarization and chain formation of nano-layered particles, Europhys. Lett., 74, 438 (2006), and in the Scientific Highlights 2006 of the European Synchrotron Radiation Facility - ESRF (2007) 6. K.P.S. Parmar, Y. Meheust, B. Schelderupsen and J.O. Fossum, Electrorheological suspensions of laponite in oil: rheometry studies, Langmuir 24,1814 (2008) 7. F. Bergaya, B. K. G. Theng, and G. Lagaly, editors. Handbook of Clay Science. Elsevier (2006)

PREFACE: International Conference on the Use of X-ray (and related) Techniques in Arts and Cultural Heritage (XTACH 11)

NASA Astrophysics Data System (ADS)

Hamdan, Nasser; El-Khatib, Sami

2012-07-01

), Raman measurements, as well as other sample preparation techniques. The training course concluded with a series of presentations of the results by the participants, attended by the NXFL team and experts from the IAEA. This training course was organized as part of the activities of the IAEA technical cooperation RAS1011 Project: Using Ion Beam Analysis and Complementary Nuclear Techniques for Material Characterization in ARASIA State Parties. The course was attended by participants from Iraq, Jordan, Lebanon, Qatar, Syria, the United Arab Emirates and Yemen. We would like to thank the conference sponsors: Tashkeel, Sharjah Museums, and Sharjah Department of Culture and Information (Directorate on Antiquities). We would also like to thank our invited speakers, the international advisory committee, the referees and the participants. It has been a pleasure working with them all. Organizing Committee Nasser Hamdan AUS, NXFL Members Pia Anderson AUS Hussain Al-Awadhi UoS & NXFL Sami El Khatib AUS Attaelmanan Gaffar UoS & NXFL Johannes Giesen AUS Sabah Jasim Directory of Antiquities Sharjah Najeh Jisrawi UoS & NXFL Adil Tamimi AUS International Advisory Committee Zaki Aslan ATHAR, ICCROM, Italy Mark Beech Abu Dhabi Culture & Heritage, UAE Rene Van Grieken University of Antwerp, Belgium Gene Hall Rutgers, The State University of N.J. Peter Jackson Office of the Ruler of Sharjah Andreas Karydas IAEA Laboratories, Seiberdorf, Austria Giacinto Porco The Italian Association of Non-Destructive Testing, Italy Mohammad Roumie (CNRS) Lebanese Atomic Energy, Commission, Lebanon Acknowledgments The organizers gratefuly acknowledge the support received from the College of Arts and Sciences and the Provosts office at the American University of Sharjah. The support of the Physics Section, Division of Physical and Chemical Sciences at the IAEA is greatly appreciated. We would like to give special thanks to Dr Francoise Muelhauser from the IAEA. We would like also to thank the conference

PREFACE New developments in nanopore research—from fundamentals to applications New developments in nanopore research—from fundamentals to applications

NASA Astrophysics Data System (ADS)

Albrecht, Tim; Edel, Joshua B.; Winterhalter, Mathias

2010-11-01

refereeing process, and Ms Natalia Goehring for the beautiful cover artwork. Finally, to the readers, we hope you find this special issue a valuable source of information and insight into the field of nanopores. New developments in nanopore research—from fundamentals to applications contents Mathematical modeling and simulation of nanopore blocking by precipitation M-T Wolfram, M Burger and Z S Siwy Protein conducting nanopores Anke Harsman, Vivien Krüger, Philipp Bartsch, Alf Honigmann, Oliver Schmidt, Sanjana Rao, Christof Meisinger and Richard Wagner Electrically sensing protease activity with nanopores Mikiembo Kukwikila and Stefan Howorka Electrical characterization of DNA-functionalized solid state nanopores for bio-sensing V Mussi, P Fanzio, L Repetto, G Firpo, P Scaruffi, S Stigliani, M Menotta, M Magnani, G P Tonini and U Valbusa Automatable lipid bilayer formation and ion channel measurement using sessile droplets J L Poulos, S A Portonovo, H Bang and J J Schmidt Critical assessment of OmpF channel selectivity: merging information from different experimental protocols M L López, E García-Giménez, V M Aguilella and A Alcaraz Chemically modified solid state nanopores for high throughput nanoparticle separation Anmiv S Prabhu, Talukder Zaki N Jubery, Kevin J Freedman, Rafael Mulero, Prashanta Dutta and Min Jun Kim Changes in ion channel geometry resolved to sub-ångström precision via single molecule mass spectrometry Joseph W F Robertson, John J Kasianowicz and Joseph E Reiner Entropic transport of finite size particles W Riefler, G Schmid, P S Burada and P Hänggi Osmotic stress regulates the strength and kinetics of sugar binding to the maltoporin channel Philip A Gurnev, Daniel Harries, V Adrian Parsegian and Sergey M Bezrukov Detection of urea-induced internal denaturation of dsDNA using solid-state nanoporesn Alon Singer, Heiko Kuhn, Maxim Frank-Kamenetskii and Amit Meller Translocation events in a single-walled carbon nanotube Jin He, Hao Liu, Pei Pang