Demystifying RPA Operations Post OEF: Now is the Time for the USAF ISR Team to Enhance Multilateral Partnership Across COCOMs and Reverse the Tide of Public Opinion Toward Intelligence Gathering and Kinetic RPA Strikes

DTIC Science & Technology

2013-04-03

Drone Practices in Pakistan (September, 2012), http://livingunderdrones.org. V. 10 Ibid., 136 -137. 11 Ibid. 12 Baldor, Lolita C., “Military...http://cnn.com. 3. 31 Baldor, Lolita C., “Military Weighs Cutbacks, Shifts in Drone Programs,” adn.com, 02 Feb 2013, www.adn.com...Piloted ISR Aircraft.” Air and Space Power Journal, (Spring 2011): 45. 35 Ibid., 46. 36 Baldor, Lolita C., “Military Weighs Cutbacks, Shifts in

Stakeholder Analysis of Integrating Women Into Ground Combat Units

DTIC Science & Technology

2014-06-01

article posted on SaukValley.com titled “Sources: Pentagon Rules Shift on Women in Combat,” Lolita C. Baldor cites Bhagwati regarding news about plans...Jan-13 AP Sources: Pentagon Open Combat Roles to Women Lolita C. Baldor Associated Press 17-Jan-14 Military Women in Combat Nancy Carol Squidoo...Security Journal 9-Feb-12 Sources: Pentagon rules shift on women in combat Lolita C. Baldor SaukValley.com 24-Oct-13 A Voice for Men None named

Army Drawdown and Restructuring: Background and Issues for Congress

DTIC Science & Technology

2012-05-18

Information in this section is taken from Lolita C. Baldor, “Army Chief Sees Greater Role for Guard and Reserves,” Norfolk Virginian-Pilot, January 27...requirements? 90 Information in this section is taken from Lolita C. Baldor, “Army Chief Sees

Rushing to Failure Impacts of a Gender-Neutral Military on Combat Effectiveness

DTIC Science & Technology

2016-02-16

interview by the author, 24 August 2015. 25 36 Lolita C. Baldor, “Marine general predicts Pentagon vows to maintain equal standards for men and...www.marinecorpstimes.com/story/military/2015/12/20/marine-recruiters-dont-expect- sharp-rise-female-accessions/77382086/. Baldor, Lolita C

General Information about Mycosis Fungoides and the Sezary Syndrome

MedlinePlus

... Including Sézary Syndrome) Treatment (PDQ®)–Patient Version General Information About Mycosis Fungoides (Including Sézary Syndrome) Go to ... the PDQ Adult Treatment Editorial Board . Clinical Trial Information A clinical trial is a study to answer ...

Army Drawdown and Restructuring: Background and Issues for Congress

DTIC Science & Technology

2013-01-03

trained up and be available for 9 28 Information in this section is taken from Lolita C. Baldor, “Army...2012. 93 Information in this section is taken from Lolita C. Baldor, “Army Chief Sees Greater Role for Guard and Reserves,” Norfolk Virginian-Pilot

Army Drawdown and Restructuring: Background and Issues for Congress

DTIC Science & Technology

2012-04-20

26 Information in this section is taken from Lolita C. Baldor, “Army Chief Sees Greater Role for Guard and Reserves...Afghan Advisory Mission,” American Forces Press Service, February 21, 2012. 84 Information in this section is taken from Lolita C. Baldor, “Army Chief

The Army Profession: A Narrative

DTIC Science & Technology

2013-05-23

profile cases of alleged misconduct” were symptomatic of “a much larger issue affecting the armed forces.”9 In the Associated Press, Lolita Baldor...Science: An Academic Discipline." Army Magazine, no. 5 (May 2005): 14-15. Baldor, Lolita C. and Michael Biesecker. "US Army Brigadier General

First-Strike Advantage: The United States’ Counter to China’s Preemptive Integrated Network Electronic Warfare Strategy

DTIC Science & Technology

2013-06-01

Ground: Chinese Capabilities for Computer Network Operations and Cyber Espionage,” 9. 57 Lolita C. Baldor, “Chinese Cyber Attacks On U.S. Continue...the Secretary of Defense, 2009. Baldor, Lolita C. “Chinese Cyber Attacks on U.S. Continue Totally Unabated, Leon Panetta.” Huffington Post (2012

Limiting Regret: Building the Army We Will Need

DTIC Science & Technology

2015-01-01

Rise of Taliban,” London Sunday Times, October 12, 2008; Lolita C. Baldor, “General: Urgent Need for Troops in Afghanistan Now,” Miami Herald...See Lolita C. Baldor, “War Demands Strain Military Readiness,” USA Today, February 9, 2008; Tom Philpott, “Mullen: Money Crisis Will Impact

Preventing Health Damaging Behaviors in Male and Female Army Recruits

DTIC Science & Technology

2013-08-01

completed in 2004: 1. Fort Bragg, NC: MAJ Lolita Burrell (then CPT (P), Richard Carr, and Crystal Ross were briefed. MAJ Burrell was tasked with...BCT, Fort Jackson, SC (July 2006). As a result of several conference calls with LTC Corum, Drs. Boyer and Shafer and MAJ Lolita Burrell, WAMC-Ft

Defense Strategy for the Next Decade: Joint Security Cooperation and AirSea Battle Operations

DTIC Science & Technology

2012-05-07

10 April 2012). 36 Lolita C. Baldor, “Army restructuring includes cuts to combat brigades,” The Associated Press, 26 January 2012, http://www.post... Lolita C. “Army Restructuring Includes Cuts To Combat Brigades.” The Associated Press, 26 January 2012. http://www.postgazette.com/pg/12026/1206081-84

Blunting the Spear: Why Good People Get Out

DTIC Science & Technology

2013-06-01

enterprise to fill MCE, LRE, FTU, and additional billets. 17 Hardison, Mattock, Lytell, Incentive Pay for RPA, xiv. 18 Lolita C. Baldor, “Next Top...Air Force Website, 17 January 2013. 169 (Accessed 22 January 2013). Baldor, Lolita C. “Next Top Guns? Air Force faces Shortage of Drone Pilots

Defining Army Capabilities to Meet Building Partnership Capacity Requirements

DTIC Science & Technology

2012-05-17

111 Lolita C. Baldor, “U.S. officials plan deep changes in combat brigades,” Philly.com, entry posted January 26, 2012, http://articles.philly.com... Lolita C., “U.S. officials plan deep changes in combat brigades.” Philly.com, entry posted January 26, 2012, http://articles.philly.com/2012-01-26

To Strive, to Seek, to Find, and Not Yield: How Chiefs of Staff of the Army Lead Change

DTIC Science & Technology

2013-05-23

Capability examines how the Chief of Staff’s 23 Pape, “How the Army Resists Change,” 25. 24 Lolita C. Baldor and Robert Burns, Army Times (November 14, 2012...Massachusetts and London, England: Belknap Press, 2009. Baldor, Lolita C. and Robert Burns. Army Times. November 14, 2012. www.Armytimes.com/new/2012

Advancing U.S. Strategic Communication through Greater Civilian-Military Coordination and Integration

DTIC Science & Technology

2012-06-01

UN and other multilateral institutions. 17 16 Lolita Balder, "Pentagon propaganda an effort to "get the truth out," Associated Press, printed in the...middle east/3578183.stm (accessed March 2, 2012). Lolita Baldor, "Pentagon propaganda an effort to "get the truth out," Associated Press, printed in

Closing the Candor Chasm: The Missing Element of Army Professionalism

DTIC Science & Technology

2013-09-01

BIBLIOGRAPHY Baldor, Lolita C. “Army Chief Sees Greater Role for Guard and Reserves.” Norfolk Virginian-Pilot. January 27, 2012. hampton- roads.com/2012/01...20. 41. Lolita C. Baldor, “Army Chief Sees Greater Role for Guard and Reserves,” Norfolk Virginian-Pilot, January 27, 2012; Budget Control Act of

Moral Waivers in Army Recruiting: It Is About Family

DTIC Science & Technology

2013-03-01

Increases Use of Moral Waivers to Meet Demand for Troops,” The Guardian, April 21 2008; and Lolita Baldor, “Army More Selective on Recruits, Re-enlistments...30 45 David Brooks, “The Psych Approach,” The New York Times, September 27, 2012. 46 Lolita Baldor, “Army More Selective on Recruits, Re

Establishing and Maintaining Trust for an Airborne Network. Search and Rescue Enterprise: Security Assessment Report

DTIC Science & Technology

2014-12-01

Area Code) (937) 528-8142 Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std. Z39-18 1 MITCHELL, LOLITA V CIV USAF AFMC AFRL/RYOX To...MITCHELL, LOLITA V CIV USAF AFMC AFRL/RYOX Subject: FW: Final Report Change - Search and Rescue Security Assessment From: J M Schlesselman [mailto:joe

The Maharaja’s New AVTAAR: Air-Refuelling Strategy for the Indian Air Force

DTIC Science & Technology

2013-06-01

and Lolita C Baldor, "Boeing gets $35 Billion Air Force Tanker Order," Aviation on NBC News.com. Feruary 24, 2011. http://www.nbcnews.com/id/41766812...rakshak.com/NAVY/Ships/Active/156-Nicobar-Class.html (accessed March 23, 2013). Cassata, Donna, and Lolita C Baldor. "Boeing gets $35 Billion Air Force

Strategy-Policy Mismatch: How the U.S. Army Can Help Close Gaps in Countering Weapons of Mass Destruction

DTIC Science & Technology

2014-01-01

Niblack, and Dana J. Johnson, A League of Airmen: U.S. Air Power in the Gulf War, Santa Monica, Calif.: RAND Corporation, MR-343-AF, 1994. 8 Lolita C...Sanger, and Anne Barnard, “Off-the-Cuff Obama Line Put U.S. in Bind on Syria,” New York Times, May 4, 2013. Baldor, Lolita C., “U.S. Troops Could

The Effects of DHEA on Resilience to PTSD

DTIC Science & Technology

2011-04-01

Resilience to PTSD Authors Cassandra M. Ellington Scott J. Wright Lolita M. Burrell Michael D. Matthews United States Military Academy...to PTSD 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Cassandra Ellington; Scott Wright; Lolita Burrell; Michael...Chilcoat, H. D., Kessler, R. C., Peterson, E. L., & Lucia, V. C. (1999). Vulnerability to assaultive violence: Further specification of the sex

Public Confidence and the U.S. Military

DTIC Science & Technology

2012-03-16

speech.aspx?id=1672 (accessed January 6, 2012). 24 39 Baldor, Lolita C. “Panetta Faces lawmakers on Defense Cuts,” October 13, 2011 http...20strategy %20is%20based%20on% 20a%20false%20premise%20»%20Center%20For%20Defense%20Studies.webarchive (accessed 5 March, 2012). 48 Lolita Baldor, “Panetta Faces lawmakers on Defense Cuts”, 1.

Outcomes after diagnosis of mycosis fungoides and Sézary syndrome before 30 years of age: a population-based study.

PubMed

Ai, Weiyun Z; Keegan, Theresa H; Press, David J; Yang, Juan; Pincus, Laura B; Kim, Youn H; Chang, Ellen T

2014-07-01

Mycosis fungoides and Sézary syndrome (MF/SS) are rare in children and young adults, and thus the incidence and outcomes in this patient population are not well studied. To assess the incidence and outcomes of MF/SS in patients diagnosed before 30 years of age. Retrospective study of 2 population-based cancer registries-the California Cancer Registry (n = 204) and 9 US cancer registries of the Surveillance, Epidemiology, and End Results program (SEER 9; n = 195)-for patients diagnosed with MF/SS before 30 years of age. Overall survival was calculated by the Kaplan-Meier method. The risk of a second cancer was assessed by calculating the standard incidence ratio (SIR) comparing observed cancer incidence in patients with MF/SS with the expected incidence in the age-, sex-, and race-standardized general population. The incidence of MF/SS is rare before 30 years of age, with an incidence rate of 0.05 per 100,000 persons per year before age 20 years and 0.12 per 100,000 persons per year between ages 20 and 29 years in the California Cancer Registry. At 10 years, patients with MF/SS had an overall survival of 94.3% (95% CI, 89.6%-97.2%) in the California Cancer Registry and 88.9% (95% CI, 82.4%-93.2%) in SEER 9. In SEER 9, there was a significant excess risk of all types of second cancers combined (SIR, 3.40; 95% CI, 1.55-6.45), particularly lymphoma (SIR, 12.86; 95% CI, 2.65-37.59) and melanoma (SIR, 9.31; 95% CI, 8.75-33.62). In the California Cancer Registry, the SIR for risk of all types of second cancers was similar to that in SEER 9 (SIR, 3.45; 95% CI, 0.94-8.83), although not statistically significant. Young patients with MF/SS have a favorable outcome, despite a strong suggestion of an increased risk of second primary cancers. Prolonged follow-up is warranted to definitively assess their risk of developing second cancers in a lifetime.

Aberrant expression of the tyrosine kinase receptor EphA4 and the transcription factor twist in Sézary syndrome identified by gene expression analysis.

PubMed

van Doorn, Remco; Dijkman, Remco; Vermeer, Maarten H; Out-Luiting, Jacoba J; van der Raaij-Helmer, Elisabeth M H; Willemze, Rein; Tensen, Cornelis P

2004-08-15

Sézary syndrome (Sz) is a malignancy of CD4+ memory skin-homing T cells and presents with erythroderma, lymphadenopathy, and peripheral blood involvement. To gain more insight into the molecular features of Sz, oligonucleotide array analysis was performed comparing gene expression patterns of CD4+ T cells from peripheral blood of patients with Sz with those of patients with erythroderma secondary to dermatitis and healthy controls. Using unsupervised hierarchical clustering gene, expression patterns of T cells from patients with Sz were classified separately from those of benign T cells. One hundred twenty-three genes were identified as significantly differentially expressed and had an average fold change exceeding 2. T cells from patients with Sz demonstrated decreased expression of the following hematopoietic malignancy-linked tumor suppressor genes: TGF-beta receptor II, Mxi1, Riz1, CREB-binding protein, BCL11a, STAT4, and Forkhead Box O1A. Moreover, the tyrosine kinase receptor EphA4 and the potentially oncogenic transcription factor Twist were highly and selectively expressed in T cells of patients with Sz. High expression of EphA4 and Twist was also observed in lesional skin biopsy specimens of a subset of patients with cutaneous T cell lymphomas related to Sz, whereas their expression was nearly undetectable in benign T cells or in skin lesions of patients with inflammatory dermatoses. Detection of EphA4 and Twist may be used in the molecular diagnosis of Sz and related cutaneous T-cell lymphomas. Furthermore, the membrane-bound EphA4 receptor may serve as a target for directed therapeutic intervention.

Using Heart Rate to Predict Resilience and Susceptibility to PTSD in Soldiers

DTIC Science & Technology

2011-04-01

Predict Resilience and Susceptibility to PTSD in Soldiers Authors Brian Chung Jonathan Lanier Lolita M. Burrell Michael D. Matthews...AUTHOR(S) Brian Chung; Jonathan Lanier; Lolita Burrell; Michael Matthews 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING...members of the control group were matched with one of the trauma or PTSD victims based on age and sex and both individuals were shown the same

Oral and Cutaneous Lymphomas other than Mycosis Fungoides and Sézary Syndrome in a Mexican Cohort: Recategorization and Evaluation of International Geographical Disparities

PubMed Central

Hernández-Salazar, Amparo; García-Vera, Jorge Andrés; Charli-Joseph, Yann; Ortiz-Pedroza, Guadalupe; Méndez-Flores, Silvia; Orozco-Topete, Rocío; Morales-Leyte, Ana Lilia; Domínguez-Cherit, Judith; Lome-Maldonado, Carmen

2017-01-01

Background: Nonmycosis fungoides/Sézary syndrome (non-MF/SS) primary cutaneous lymphomas (PCL) are currently categorized under the 2005-World Health Organization/European Organization for Research and Treatment of Cancer (WHO-EORTC) classification for PCL. These differ in behavior from secondary cutaneous lymphomas (SCL) and to lymphomas limited to the oral cavity (primary oral lymphomas [POL]) both categorized under the 2016-WHO classification for lymphoid neoplasms. Aims: This study aims to report the first series of non-MF/SS PCL, SCL, and POL in a Mexican cohort, examine the applicability of current classification systems and compare our findings with those from foreign cohorts. Materials and Methods: Eighteen non-MF/SS PCL, four SCL, and two POL with available tissue for morphology and immunophenotypic assessment were reclassified according to the 2005-WHO/EORTC and 2016-WHO classifications. Results: Non-MF/SS PCLs were primarily of T-cell origin (61%) where CD30+ lymphoproliferative disorders predominated, followed by Epstein–Barr virus-induced lymphomas, and peripheral T-cell lymphomas, not otherwise specified. Primary cutaneous B-cell lymphomas (BCL) were primarily of follicle center cell origin followed by postgerminal lymphomas of the diffuse large BCL variety. Conclusions: Most non-MF/SS PCL, SCL, and POL can be adequately categorized according to the 2005-WHO/EORTC and 2016-WHO classification systems, even when dealing with clinically atypical cases. The relative frequencies in our cohort hold closer similarities to Asian registries than from those of Europe/USA, supporting the concept of individual and/or racial susceptibility, and the notion of geographical variances in the rate of lymphomas. In particular, such disparity may arise from viral-induced lymphomas which might show partial geographical restriction. PMID:28400635

Military Health Behaviors: Promotion of Healthy Weight and Fitness in Career Personnel

DTIC Science & Technology

2006-05-01

Lolita M. Burrell, Ph.D. CONTRACTING ORGANIZATION: Pennington Biomedical Research Center 6400 Perkins Rd. Baton Rouge, LA 70808-4124...FADA, and MAJ Lolita M. Burrell, Ph.D 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING...Website Launch Plan: 1) July 24th: WAMC and Ft. Bragg “Media Blitz” - Interview with Paraglide, WAMC PAO - Photo -op with WAMC and Ft. Bragg VIPS

A distinct profile of serum levels of soluble intercellular adhesion molecule-1 and intercellular adhesion molecule-3 in mycosis fungoides and Sézary syndrome.

PubMed

López-Lerma, Ingrid; Estrach, Maria Teresa

2009-08-01

Cell adhesion molecules (CAMs) play a pivotal role in cutaneous localization of T cells. Tissue-selective localization of T lymphocytes to the skin is crucial for immune surveillance and in the pathogenesis of skin disorders. To detect the profile of soluble CAMs in patients with cutaneous T-cell lymphoma (CTCL), we investigated the levels of intercellular adhesion molecule-1 (ICAM-1, soluble ICAM-1 [sICAM-1]); intercellular adhesion molecule-3 (sICAM-3); vascular cell adhesion molecule-1 (sVCAM-1); and E-selectin (sE-selectin) in sera from patients with T-cell-mediated skin diseases. Serum levels of the 4 CAMs were measured by enzyme-linked immunosorbent assay in 42 participants including 11 patients with early stages of CTCL; 7 with advanced stages of CTCL including Sézary syndrome; 12 with inflammatory skin diseases (psoriasis and atopic dermatitis); 8 with skin diseases that may evolve into CTCL; and healthy individuals. Levels were correlated with biological parameters known as prognostic factors in non-Hodgkin lymphomas. In patients with CTCL, significantly increased levels of sICAM-1 and sICAM-3 were found when compared with healthy individuals and patients with inflammatory dermatosis. Soluble E-selectin and sVCAM-1 levels were not increased. There were significant positive correlations between sICAM-1 and sICAM-3 levels and each of them with beta2-microglobulin levels. Limited number of patients was a limitation. There is a distinct profile of soluble CAMs in patients with CTCL. However, future studies with a larger group of patients are needed to confirm these findings. We propose that high sICAM-1 and sICAM-3 levels have important implications in the context of immune response and immune surveillance in these patients.

Vague-to-Crisp Dynamics of Percept Formation Modeled as Operant (Selectionist) Process

DTIC Science & Technology

2013-04-04

simplifying heuristics versus careful thinking: scientific analysis of millennial spiritual issues. Zygon J Sci Religion 43(4):797 821 Li Y , Nara S (2008...and the pleasures of learning: wanting and liking new information. Cogn Emot 19(6):793 814 Neiman T, Loewenstein Y (2013) Covariance based synaptic

Clinical End Points and Response Criteria in Mycosis Fungoides and Sézary Syndrome: A Consensus Statement of the International Society for Cutaneous Lymphomas, the United States Cutaneous Lymphoma Consortium, and the Cutaneous Lymphoma Task Force of the European Organisation for Research and Treatment of Cancer

PubMed Central

Olsen, Elise A.; Whittaker, Sean; Kim, Youn H.; Duvic, Madeleine; Prince, H. Miles; Lessin, Stuart R.; Wood, Gary S.; Willemze, Rein; Demierre, Marie-France; Pimpinelli, Nicola; Bernengo, Maria Grazia; Ortiz-Romero, Pablo L.; Bagot, Martine; Estrach, Teresa; Guitart, Joan; Knobler, Robert; Sanches, José Antonio; Iwatsuki, Keiji; Sugaya, Makoto; Dummer, Reinhard; Pittelkow, Mark; Hoppe, Richard; Parker, Sareeta; Geskin, Larisa; Pinter-Brown, Lauren; Girardi, Michael; Burg, Günter; Ranki, Annamari; Vermeer, Maartan; Horwitz, Steven; Heald, Peter; Rosen, Steve; Cerroni, Lorenzo; Dreno, Brigette; Vonderheid, Eric C.

2011-01-01

Mycosis fungoides (MF) and Sézary syndrome (SS), the major forms of cutaneous T-cell lymphoma, have unique characteristics that distinguish them from other types of non-Hodgkin's lymphomas. Clinical trials in MF/SS have suffered from a lack of standardization in evaluation, staging, assessment, end points, and response criteria. Recently defined criteria for the diagnosis of early MF, guidelines for initial evaluation, and revised staging and classification criteria for MF and SS now offer the potential for uniform staging of patients enrolled in clinical trials for MF/SS. This article presents consensus recommendations for the general conduct of clinical trials of patients with MF/SS as well as methods for standardized assessment of potential disease manifestations in skin, lymph nodes, blood, and visceral organs, and definition of end points and response criteria. These guidelines should facilitate collaboration among investigators and collation of data from sponsor-generated or investigator-initiated clinical trials involving patients with MF or SS. PMID:21576639

Phase II Investigator-Initiated Study of Brentuximab Vedotin in Mycosis Fungoides and Sézary Syndrome With Variable CD30 Expression Level: A Multi-Institution Collaborative Project

PubMed Central

Kim, Youn H.; Tavallaee, Mahkam; Sundram, Uma; Salva, Katrin A.; Wood, Gary S.; Li, Shufeng; Rozati, Sima; Nagpal, Seema; Krathen, Michael; Reddy, Sunil; Hoppe, Richard T.; Nguyen-Lin, Annie; Weng, Wen-Kai; Armstrong, Randall; Pulitzer, Melissa; Advani, Ranjana H.; Horwitz, Steven M.

2015-01-01

Purpose In contrast to Hodgkin lymphoma and systemic anaplastic large-cell lymphoma, CD30 expression of malignant lymphocytes in mycosis fungoides (MF) and Sézary syndrome (SS) is quite variable. Clinical activity and safety of brentuximab vedotin, a CD30 targeting antibody-drug conjugate, was evaluated in MF and SS. Tissue and blood biomarkers of clinical response were explored. Patients and Methods In this phase II study, patients with MF or SS with negligible to 100% CD30 expression levels were treated with brentuximab vedotin (1.8 mg/kg) every 3 weeks for a maximum of sixteen doses. The primary end point was overall global response rate. Secondary end points included correlation of tissue CD30 expression level with clinical response, time to response, duration of response, progression-free and event-free survivals, and safety. Results Of the 32 patients enrolled and treated, 30 patients had available efficacy evaluations. Objective global response was observed in 21 (70%) of 30 patients (90% CI, 53% to 83%). CD30 expression assessed by immunohistochemistry was highly variable, with a median CD30max of 13% (range, 0% to 100%). Those with <5% CD30 expression had a lower likelihood of global response than did those with 5% or greater CD30 expression (P < .005). CD163 positive tumor-associated macrophages, many of which coexpress CD30, were abundant in tissue. Peripheral neuropathy was the most common adverse event. Conclusion Brentuximab vedotin demonstrated significant clinical activity in treatment-refractory or advanced MF or SS with a wide range of CD30 expression levels. Additional biomarker studies may help optimize rational design of combination therapies with brentuximab vedotin. PMID:26195720

Contracting Improvements Still Needed in DoD’s FY 2011 Purchases Made Through the Department of Veterans Affairs

DTIC Science & Technology

2012-12-07

Neiman Street Fort Detrick, MD 21702 Federal Supply Schedule 3) W81XWH-11-F-0122 332,069 Parts to rebuild Zoll Defibrillators , including...USA Medical Dept Activity Bldg 42817 Reilly Road Fort Bragg, NC 28310 Federal Supply Schedule 9) W91YTZ-11-F-0064 163,409 Defibrillators /Monitors

Public School Safety and Discipline: 2013-14. First Look. NCES 2015-051

ERIC Educational Resources Information Center

Gray, Lucinda; Lewis, Laurie

2015-01-01

This report provides nationally representative data on public school safety and discipline for the 2013-14 school year. The National Center for Education Statistics (NCES) previously collected data on this topic in the School Survey on Crime and Safety (SSOCS), which was last conducted in the 2009-10 school year (Neiman 2011). This report presents…

The Use of Central Pathology Review With Digital Slide Scanning in Advanced-stage Mycosis Fungoides and Sézary Syndrome: A Multi-institutional and International Pathology Study.

PubMed

Gru, Alejandro A; Kim, Jinah; Pulitzer, Melissa; Guitart, Joan; Battistella, Maxime; Wood, Gary S; Cerroni, Lorenzo; Kempf, Werner; Willemze, Rein; Pawade, Joya; Querfeld, Christiane; Schaffer, Andras; Pincus, Laura; Tetzlaff, Michael; Duvic, Madeleine; Scarisbrick, Julia; Porcu, Pierluigi; Mangold, Aaron R; DiCaudo, David J; Shinohara, Michi; Hong, Eric K; Horton, Bethany; Kim, Youn H

2018-06-01

This pathology PILOT study aims to define the role and feasibility of centralized pathology review in a cohort of 75 patients from different centers in the United States and Europe using digital slide scanning. The pathologic material from 75 patients who had been diagnosed with mycosis fungoides/Sézary syndrome and were clinically staged as IIb or above was retrieved from 11 participating centers. Each pathology reviewer was provided with the pathologic diagnosis (by the referring pathologist), and the following list of histopathologic criteria (presence or absence) from the initial report: epidermotropism, folliculotropism (FT), large cell transformation, syringotropism, and granulomas. Patients with advance stage were selected for this study as this is a population where there is significant variability in the diagnosis of pathologic prognostic and predictive biomarkers. The slides were digitally scanned with an Aperio scanner and consensus review of cases occurred when major or minor discrepancies between the referral diagnosis and central pathology review occurred. Among the 75 cases, 70 (93.3%) had a final consensus diagnosis between the 3 central review pathologists. The overall agreement between the consensus review and the referring pathologist was 60%. The overall agreement was also higher between the reviewers and consensus review, compared with the referring pathologist and consensus. 65.3% of cases had some type of discrepancy (major or minor) between the outside and consensus review. Major discrepancies were seen in 34 of 73 cases (46.6%; 73 cases indicated a yes or no response). Minor discrepancies were seen in 32 of 75 (42.7%) of cases. Most of the major discrepancies were accounted by a difference in interpretation in the presence or absence of large cell transformation or FT. Most minor discrepancies were explained by a different interpretation in the expression of CD30. We found digital slide scanning to be a beneficial, reliable, and practical

Cutaneous Lymphoma International Consortium Study of Outcome in Advanced Stages of Mycosis Fungoides and Sézary Syndrome: Effect of Specific Prognostic Markers on Survival and Development of a Prognostic Model

PubMed Central

Scarisbrick, Julia J.; Prince, H. Miles; Vermeer, Maarten H.; Quaglino, Pietro; Horwitz, Steven; Porcu, Pierluigi; Stadler, Rudolf; Wood, Gary S.; Beylot-Barry, Marie; Pham-Ledard, Anne; Foss, Francine; Girardi, Michael; Bagot, Martine; Michel, Laurence; Battistella, Maxime; Guitart, Joan; Kuzel, Timothy M.; Martinez-Escala, Maria Estela; Estrach, Teresa; Papadavid, Evangelia; Antoniou, Christina; Rigopoulos, Dimitis; Nikolaou, Vassilki; Sugaya, Makoto; Miyagaki, Tomomitsu; Gniadecki, Robert; Sanches, José Antonio; Cury-Martins, Jade; Miyashiro, Denis; Servitje, Octavio; Muniesa, Cristina; Berti, Emilio; Onida, Francesco; Corti, Laura; Hodak, Emilia; Amitay-Laish, Iris; Ortiz-Romero, Pablo L.; Rodríguez-Peralto, Jose L.; Knobler, Robert; Porkert, Stefanie; Bauer, Wolfgang; Pimpinelli, Nicola; Grandi, Vieri; Cowan, Richard; Rook, Alain; Kim, Ellen; Pileri, Alessandro; Patrizi, Annalisa; Pujol, Ramon M.; Wong, Henry; Tyler, Kelly; Stranzenbach, Rene; Querfeld, Christiane; Fava, Paolo; Maule, Milena; Willemze, Rein; Evison, Felicity; Morris, Stephen; Twigger, Robert; Talpur, Rakhshandra; Kim, Jinah; Ognibene, Grant; Li, Shufeng; Tavallaee, Mahkam; Hoppe, Richard T.; Duvic, Madeleine; Whittaker, Sean J.; Kim, Youn H.

2015-01-01

Purpose Advanced-stage mycosis fungoides (MF; stage IIB to IV) and Sézary syndrome (SS) are aggressive lymphomas with a median survival of 1 to 5 years. Clinical management is stage based; however, there is wide range of outcome within stages. Published prognostic studies in MF/SS have been single-center trials. Because of the rarity of MF/SS, only a large collaboration would power a study to identify independent prognostic markers. Patients and Methods Literature review identified the following 10 candidate markers: stage, age, sex, cutaneous histologic features of folliculotropism, CD30 positivity, proliferation index, large-cell transformation, WBC/lymphocyte count, serum lactate dehydrogenase, and identical T-cell clone in blood and skin. Data were collected at specialist centers on patients diagnosed with advanced-stage MF/SS from 2007. Each parameter recorded at diagnosis was tested against overall survival (OS). Results Staging data on 1,275 patients with advanced MF/SS from 29 international sites were included for survival analysis. The median OS was 63 months, with 2- and 5-year survival rates of 77% and 52%, respectively. The median OS for patients with stage IIB disease was 68 months, but patients diagnosed with stage III disease had slightly improved survival compared with patients with stage IIB, although patients diagnosed with stage IV disease had significantly worse survival (48 months for stage IVA and 33 months for stage IVB). Of the 10 variables tested, four (stage IV, age > 60 years, large-cell transformation, and increased lactate dehydrogenase) were independent prognostic markers for a worse survival. Combining these four factors in a prognostic index model identified the following three risk groups across stages with significantly different 5-year survival rates: low risk (68%), intermediate risk (44%), and high risk (28%). Conclusion To our knowledge, this study includes the largest cohort of patients with advanced-stage MF/SS and

Cutaneous Lymphoma International Consortium Study of Outcome in Advanced Stages of Mycosis Fungoides and Sézary Syndrome: Effect of Specific Prognostic Markers on Survival and Development of a Prognostic Model.

PubMed

Scarisbrick, Julia J; Prince, H Miles; Vermeer, Maarten H; Quaglino, Pietro; Horwitz, Steven; Porcu, Pierluigi; Stadler, Rudolf; Wood, Gary S; Beylot-Barry, Marie; Pham-Ledard, Anne; Foss, Francine; Girardi, Michael; Bagot, Martine; Michel, Laurence; Battistella, Maxime; Guitart, Joan; Kuzel, Timothy M; Martinez-Escala, Maria Estela; Estrach, Teresa; Papadavid, Evangelia; Antoniou, Christina; Rigopoulos, Dimitis; Nikolaou, Vassilki; Sugaya, Makoto; Miyagaki, Tomomitsu; Gniadecki, Robert; Sanches, José Antonio; Cury-Martins, Jade; Miyashiro, Denis; Servitje, Octavio; Muniesa, Cristina; Berti, Emilio; Onida, Francesco; Corti, Laura; Hodak, Emilia; Amitay-Laish, Iris; Ortiz-Romero, Pablo L; Rodríguez-Peralto, Jose L; Knobler, Robert; Porkert, Stefanie; Bauer, Wolfgang; Pimpinelli, Nicola; Grandi, Vieri; Cowan, Richard; Rook, Alain; Kim, Ellen; Pileri, Alessandro; Patrizi, Annalisa; Pujol, Ramon M; Wong, Henry; Tyler, Kelly; Stranzenbach, Rene; Querfeld, Christiane; Fava, Paolo; Maule, Milena; Willemze, Rein; Evison, Felicity; Morris, Stephen; Twigger, Robert; Talpur, Rakhshandra; Kim, Jinah; Ognibene, Grant; Li, Shufeng; Tavallaee, Mahkam; Hoppe, Richard T; Duvic, Madeleine; Whittaker, Sean J; Kim, Youn H

2015-11-10

Advanced-stage mycosis fungoides (MF; stage IIB to IV) and Sézary syndrome (SS) are aggressive lymphomas with a median survival of 1 to 5 years. Clinical management is stage based; however, there is wide range of outcome within stages. Published prognostic studies in MF/SS have been single-center trials. Because of the rarity of MF/SS, only a large collaboration would power a study to identify independent prognostic markers. Literature review identified the following 10 candidate markers: stage, age, sex, cutaneous histologic features of folliculotropism, CD30 positivity, proliferation index, large-cell transformation, WBC/lymphocyte count, serum lactate dehydrogenase, and identical T-cell clone in blood and skin. Data were collected at specialist centers on patients diagnosed with advanced-stage MF/SS from 2007. Each parameter recorded at diagnosis was tested against overall survival (OS). Staging data on 1,275 patients with advanced MF/SS from 29 international sites were included for survival analysis. The median OS was 63 months, with 2- and 5-year survival rates of 77% and 52%, respectively. The median OS for patients with stage IIB disease was 68 months, but patients diagnosed with stage III disease had slightly improved survival compared with patients with stage IIB, although patients diagnosed with stage IV disease had significantly worse survival (48 months for stage IVA and 33 months for stage IVB). Of the 10 variables tested, four (stage IV, age > 60 years, large-cell transformation, and increased lactate dehydrogenase) were independent prognostic markers for a worse survival. Combining these four factors in a prognostic index model identified the following three risk groups across stages with significantly different 5-year survival rates: low risk (68%), intermediate risk (44%), and high risk (28%). To our knowledge, this study includes the largest cohort of patients with advanced-stage MF/SS and identifies markers with independent prognostic value

Navy Virginia (SSN 774) Class Attack Submarine Procurement: Background and Issues for Congress

DTIC Science & Technology

2016-04-14

programs before the Seapower subcommittee of the Senate Armed Services Committee, the following exchange occurred: SENATOR KELLY AYOTTE (continuing... Bryan Bender, “Navy Eyes Cutting Submarine Force,” Boston Globe, May 12, 2004, p. 1; Lolita C. Baldor, “Study Recommends Cutting Submarine Fleet

Why Can’t Anything Be Done? Measuring Physical Readiness of Women for Military Occupations

DTIC Science & Technology

2011-10-01

against standards precludes reliable determination of the physical capabilities soldiers of either sex must possess to do their job.”6 Nevertheless, the...Lester, Mark E., CPT; Joseph J. Knapik; SGT Daniel Catrambone; Amanda Antczak; Marilyn A. Sharp; MAJ Lolita Burrell; Salima Darakjy. “Effect of a

Improving the U.S. Military’s Response to Homeland Humanitarian Assistance Operations

DTIC Science & Technology

2006-05-16

Wilma: A Video -Conference Coup Mr. Fugate Seizes 300 Phones”, Wall Street Journal, 8 December 2005, A1. 30 Ibid. 15 Katrina while 5th Army was...crisis. 37 Lolita C. Baldor, “Military Shores up Hurricane Response”, Los Angeles Times, 6 May 2006, available from http

A National Security Issue: Challenges to the All-Volunteer Force

DTIC Science & Technology

2012-02-25

Command, June 16, 2011. 25 U.S. Census Bureau, “Age and Sex in the United States: 2011,” http://www.census.gov/ population/www/socdemo/age...R. Thurman, Future Soldiers and the Quality Imperative (Fort Knox, KY: United States Army Recruiting Command, 1995), 53. 37 Lolita C. Baldor

Department of Defense Information Enterprise: Strategic Plan 2010-2012

DTIC Science & Technology

2010-04-01

migrate from circuit-based technology to a converged (voice, video , and data) IP network and UC services environment. Ensure the optimal...Kevin Coleman, “Cyber Attacks on Supply Chain Systems,” Defense Tech, April 15, 2009 8 Lolita C. Baldor, “Federal Web Sites Knocked Out by Cyber Attack

A Cyberworm that Knows no Boundaries

DTIC Science & Technology

2011-01-01

Stack, 2009. During Iran’s so-called “Twitter revolution,” Twitter feeds off ered a constant stream of situational updates and links to photos and...20090721141526-32619.pdf Baldor, Lolita , “Pentagon Gets Cyberwar Guidelines,” Associated Press, June 22, 2011. Balkovich, Edward, email to the authors

Navy Virginia (SSN-774) Class Attack Submarine Procurement: Background and Issues for Congress

DTIC Science & Technology

2011-04-21

Procurement Congressional Research Service 4 Figure 1. Virginia-Class Attack Submarine Source: U.S. Navy file photo accessed by CRS on January...May 12, 2004, p. 1; Lolita C. Baldor, “Study Recommends Cutting Submarine Fleet,” NavyTimes.com, May 13, 2004. 44 U.S. Department of the Navy, An

Navy Virginia (SSN-774) Class Attack Submarine Procurement: Background and Issues for Congress

DTIC Science & Technology

2011-04-12

Research Service 4 Figure 1. Virginia-Class Attack Submarine Source: U.S. Navy file photo accessed by CRS on January 11, 2011, at http...September 2001, p. 23. 42 Bryan Bender, “Navy Eyes Cutting Submarine Force,” Boston Globe, May 12, 2004, p. 1; Lolita C. Baldor, “Study Recommends

Special Inspector General for Iraq Reconstruction

DTIC Science & Technology

2013-09-09

M. Crowley, James J. Cruz, Ginger M. Davis, Mary E. Davis, Michael P. Dawson, Corey L. Dawson, Erika H. Dennelly, Lawrence E. Dervish, Ronald J...Littlefield, Kenneth A. Lohsl, Geoffry A. Lowman, Craig L. Lucas, Ginger A. Luis, Kama Lynch, Bawlie Q. Maly, William B. Mancheno-Smoak, Lolita I. March

U.S. EPA, Pesticide Product Label, O-C CLENCIDE DETERGENT SANITIZER, 01/27/1981

EPA Pesticide Factsheets

2011-04-21

... 11 ... III .... 01111 lOll fOl' ~ to ;j lIIiuUh!S. H"llIm·,'. lll' .... f' \\lolita Iu)I.!1Il.· ',\\tll', .tI,,j dl\\. ro: ll.Jt :"dIlLln·:-, . f'an [0 1t'1II0V(! .~IW"'''' 111111 ;twi Il";I\\'\\' soli. ...

The Time is Now to Remove the Ban

DTIC Science & Technology

2008-02-08

you’re attracted to everyone who happens to be your same sex .”41 Therefore, privacy is not the true concern; it is the fear that homosexuals will...xxi. 14 Lolita C. Baldor, “Gay Arab Linguists Continue t o be Discharged,” Associated Press, 25 May 2007; available from <http://www.armytimes.com

Navy Virginia (SSN-774) Class Attack Submarine Procurement: Background and Issues for Congress

DTIC Science & Technology

2012-03-01

Source: U.S. Navy file photo accessed by CRS on January 11, 2011, at http://www.navy.mil/search/display.asp? story_id=55715. Past and Projected...September 2001, p. 23. 52 Bryan Bender, “Navy Eyes Cutting Submarine Force,” Boston Globe, May 12, 2004, p. 1; Lolita C. Baldor, “Study Recommends

What Good Is World Literature?: World Literature Pedagogy and the Rhetoric of Moral Crisis

ERIC Educational Resources Information Center

Smith, Karen R.

2011-01-01

The past decade has seen a resurgence of scholarship on world literature. The best-selling successes of "Great Books" arguments contained in Azar Nafisi's memoir "Reading Lolita in Tehran" and in Dai Sijie's novel "Balzac and the Little Chinese Seamstress" seem to mirror, on the popular front, this scholarly return to the question of world…

Navy Virginia (SSN-774) Class Attack Submarine Procurement: Background and Issues for Congress

DTIC Science & Technology

2013-09-27

Submarine Source: U.S. Navy file photo accessed by CRS on January 11, 2011, at http://www.navy.mil/search/display.asp? story_id=55715. Past and Projected...May 12, 2004, p. 1; Lolita C. Baldor, “Study Recommends Cutting Submarine Fleet,” NavyTimes.com, May 13, 2004. 51 U.S. Department of the Navy, An

The Film. The Bobbs-Merrill Series in Composition and Rhetoric.

ERIC Educational Resources Information Center

Sarris, Andrew, Ed.

Prefaced by a brief discussion of early films and film criticism, 10 essays treat selected modern directors and their works. Essays on Stanley Kubrick's "Lolita," the early works of Elia Kazan, and the response of French critics to Jerry Lewis explore the American scene, while Francois Truffaut's "Jules and Jim," the early work of Robert Bressen,…

Genetics Home Reference: Sézary syndrome

MedlinePlus

... Bastidas Torres AN, Vermeer MH, Zoutman WH, Tensen CP, Schmidt CA. Genetic rearrangements result in altered gene ... K, Knijnenburg J, Boer JM, Willemze R, Tensen CP. Oncogenomic analysis of mycosis fungoides reveals major differences ...

Lessons Learned from the Afghan Mission Network: Developing a Coalition Contingency Network

DTIC Science & Technology

2014-01-01

SIPRNet Secret Internet Protocol Router Network SOP Standard Operating Procedure SVTC Secure Video Teleconference (or –Conferencing) TTP Tactics...Voice over internet protocol (VOIP) telephone connectivity • Email • Web browsing • Secure video teleconferencing (SVTC...10, 2012. As of January 15, 2013: http://www.guardian.co.uk/world/2012/oct/10/us-troops-jordan-syria-crisis Baldor, Lolita C., and Pauline Jelinek

Psychological and Physiological Responses to Depressed Others

DTIC Science & Technology

1995-08-18

assistant for this project during the summer of 1994. In addition, I thank Lolita Burrell, my fellow graduate student for all her assistance at USUHS while...and psychotherapy for depression. To varying degrees, these approaches have been used to try to explicate problems of classification, epidemiology, sex ...participants. Interactions between same or opposite- sex partners were videotaped and scored with a behavioral coding system. Participants then completed

Achieving an Optimal Medium Altitude UAV Force Balance in Support of COIN Operations

DTIC Science & Technology

2009-02-02

and execute operations. UAS with common data links and remote video terminals (RVTs) provide input to the common operational picture (COP) and...full-motion video (FMV) is intuitive to many tactical warfighters who have used similar sensors in manned aircraft. Modern data links allow the video ...Document (AFDD) 2-9. Intelligence, Surveillance, and Reconnaissance Operations, 17 July 2007. Baldor, Lolita C. “Increased UAV reliance evident in

How Should the Joint Force Handle the Command and Control of Unmanned Aircraft Systems?

DTIC Science & Technology

2008-11-18

personnel, and control apparatus. Collectively these are the unmanned aircraft system (UAS). The outputs of a UAS can range from full motion video ...reconnaissance aircraft, like the pilotless Predator drone that provides real-time surveillance video to the battlefield.”55 He continued, “While...www.foxnews.com/story/0,2933,351964,00.html [accessed July 7, 2008]. Baldor, Lolita C. Associated Press. “Increased UAV Reliance Evident in 2009 Budget

Managing Perception: A Twenty-First Century Imperative

DTIC Science & Technology

2006-02-13

computer users not logged on, insurgents have distributed CDs and DVDs. This material, enhanced with video , soundtracks, and professional editing...news, and bloggers, and e-mails, and digital cameras, and Sony video cams, and all of these things that bring so much information near instantaneously...December 2005. 10 Lolita C. Baldor, Associated Press, “Pentagon Describes Iraq Propaganda Plan,” Miami Herald, 4 December 2005, [article on-line

The Operational Impacts of the Global Network Enterprise Construct

DTIC Science & Technology

2010-05-14

Board Task Force on Achieving Interoperability in a Net-Centric Environment, xiv. 60 Lolita Baldor, “Military Asserts Right to Return Cyber-Attacks...the commander is aware that applications such video teleconferencing and large file transfers are often not possible with subordinate units...data packets, but if there is latency along the path, services such as video or large file transfers will fail. Latency is the time delay inherent in

Operation Iraqi Freedom: Strategies, Approaches, Results, and Issues for Congress

DTIC Science & Technology

2008-12-15

The New York Times, February 23, 2008; Lolita Baldor, “Gates: Turkey Raid Won’t Solve Problems,” Washington Post, February 23, 2008; Yochi Dreazen...In April 2004, the unofficial release of graphic photos of apparent detainee abuse at Abu Ghraib generated shock and horror among people inside and...who were driving through Fallujah, were ambushed and killed—and then their bodies were mutilated and hung from a bridge. Photos of that grisly

Westernization or Modernization: The Political, Economic and Social Attitudes and Desires of the Post-Khomeini Generation in Iran

DTIC Science & Technology

2006-05-25

banned, things as simple as meeting in public with members of the opposite sex , listening to pop music, and holding hands in public became acts of...treatment of this topic see Reading Lolita In Iran: A Memoir In Books, by Azar Nafisi, or Geneive Abdo and Jonathan Lyons work, Answering Only To God...contact with members of the opposite sex . In return for these freedoms, there would be an implicit agreement to give up the call for political

Operation Iraqi Freedom: Strategies, Approaches, Results, and Issues for Congress

DTIC Science & Technology

2008-09-22

Tavernise, “Turkish Troops Enter Iraq in Pursuit of Kurdish Militants,” The New York Times, February 23, 2008; Lolita Baldor, “Gates: Turkey Raid Won’t...unofficial release of graphic photos of apparent detainee abuse at Abu Ghraib generated shock and horror among people inside and outside Iraq. Some...were mutilated and hung from a bridge. Photos of that grisly aftermath were rapidly CRS-66 232 The Iraq Governing Council (IGC) was a critical part of

Operation Iraqi Freedom: Strategies, Approaches, Results, and Issues for Congress

DTIC Science & Technology

2008-03-28

23, 2008; Lolita Baldor, “Gates: Turkey Raid Won’t Solve Problems,” Washington Post, February 23, 2008; Yochi Dreazen, “U.S. Knew of Turkey’s Plan...release of graphic photos of apparent detainee abuse at Abu Ghraib generated shock and horror among people inside and outside Iraq. Some observers have...Blackwater, who were driving through Fallujah, were ambushed and killed — and then their bodies were mutilated and hung from a bridge. Photos of that

Operation Iraqi Freedom: Strategies, Approaches, Results, and Issues for Congress

DTIC Science & Technology

2008-10-28

2008; Lolita Baldor, “Gates: Turkey Raid Won’t Solve Problems,” Washington Post, February 23, 2008; Yochi Dreazen, “U.S. Knew of Turkey’s Plan to Hit...source of popular frustration. In April 2004, the unofficial release of graphic photos of apparent detainee abuse at Abu Ghraib generated shock and...and hung from a bridge. Photos of that grisly aftermath were rapidly transmitted around the world — riveting the attention of leaders in Baghdad

Extreme daily precipitation in the Northern Sierra Precipitation 8-Station index: The combined impact of landfalling atmospheric rivers and the Sierra barrier jet

NASA Astrophysics Data System (ADS)

Cordeira, J. M.; Ralph, F. M.; Neiman, P. J.; Hughes, M.

2014-12-01

The Upper Sacramento River area is vital to California's water supply, and is susceptible to major floods. Recent studies indicate that orographic precipitation in this complex terrain involves both inland penetrating atmospheric rivers (ARs) and the Sierra barrier jet (SBJ). The southerly SBJ induces orographic precipitation along south-facing slopes in the Shasta region, whereas landfalling ARs ascend up and over the statically stable SBJ and induce orographic precipitation along west-facing upper slopes in the Northern Sierra Nevada. This paper explores the hypothesis that extreme daily precipitation here is controlled by the presence of both a landfalling AR and a SBJ. Three 10-year-long (2000-2011) observational datasets are used. ARs are identified from the Neiman et al. (2008) AR catalog that uses an SSM/I satellite-based AR-detection method from Ralph et al. (2004), whereas SBJ conditions are determined from Chico, CA wind profiler data using the method from Neiman et al. (2010). Extreme daily precipitation is identified from the average of 8 rain gauges spanning the region known as the "Northern Sierra 8-Station Index." The "index" is used by water managers to assess water supply. Extreme events are defined as the 50 largest daily precipitation totals in the index for the 10-year period (the top ~1.37%). These dates in the 8-station index are compared with the catalogs of landfalling ARs and SBJs. In summary, 46 of 50 (92%) extreme daily precipitation events are associated with landfalling ARs on either the day before or the day of precipitation, whereas 45 of 50 (90%) extreme daily precipitation events are associated with SBJ conditions. 38 of 50 (76%) extreme daily precipitation events are associated with both a landfalling AR and an SBJ. The 10 days with the largest daily precipitation in the index were all associated with both a landfalling AR and an SBJ. Thus, extreme daily precipitation in Northern California is strongly controlled by the presence of

PTSD and Suicide Risk Association: A Look at Data

DTIC Science & Technology

2013-04-01

centers and in outreach programs, arguably the word is not getting to the entire population. One can also view videos of senior DoD officials...29 13 Lolita C. Baldor, “Army Suicides for 2012 Surpass Last Year’s Numbers,” November 15, 2012, http://www.military.com/daily-news/2012/11/16...February 13, 2012. 46 United States Navy, “A Global Force for Good,” YouTube, video file, http://www.youtube.com/watch?v=EEtZ5r0CIYI, (accessed on

The development of "fab-chips" as low-cost, sensitive surface-enhanced Raman spectroscopy (SERS) substrates for analytical applications.

PubMed

Robinson, Ashley M; Zhao, Lili; Shah Alam, Marwa Y; Bhandari, Paridhi; Harroun, Scott G; Dendukuri, Dhananjaya; Blackburn, Jonathan; Brosseau, Christa L

2015-02-07

The demand for methods and technologies capable of rapid, inexpensive and continuous monitoring of health status or exposure to environmental pollutants persists. In this work, the development of novel surface-enhanced Raman spectroscopy (SERS) substrates from metal-coated silk fabric, known as zari, presents the potential for SERS substrates to be incorporated into clothing and other textiles for the routine monitoring of important analytes, such as disease biomarkers or environmental pollutants. Characterization of the zari fabric was completed using scanning electron microscopy, energy dispersive X-ray analysis and Raman spectroscopy. Silver nanoparticles (AgNPs) were prepared, characterized by transmission electron microscopy and UV-vis spectroscopy, and used to treat fabric samples by incubation, drop-coating and in situ synthesis. The quality of the treated fabric was evaluated by collecting the SERS signal of 4,4'-bipyridine on these substrates. When AgNPs were drop-coated on the fabric, sensitive and reproducible substrates were obtained. Adenine was selected as a second probe molecule, because it dominates the SERS signal of DNA, which is an important class of disease biomarker, particularly for pathogens such as Plasmodium spp. and Mycobacterium tuberculosis. Excellent signal enhancement could be achieved on these affordable substrates, suggesting that the developed fabric chips have the potential for expanding the use of SERS as a diagnostic and environmental monitoring tool for application in wearable sensor technologies.

DCoE in Action. Volume 4, Number 6, June 2011. Community Partnerships: Working Together to Support Service Members, Veterans, Families

DTIC Science & Technology

2011-06-01

worldwide in the war on terrorism. U.S. Air Force photo by Staff Sgt. Bennie J. Davis III DCoE Real Warriors Campaign DCoE Real Warriors Campaign DCoE...resilience, recovery and reintegration, it can often be hard for them to choose what best fits their needs,” said Dr. Lolita O’Donnell, deputy director...Force photo by Airman 1st Class Clayton Lenhardt See INITIATIVE on Page 5 new s R esilience  R ecovery  R eintegration 3 DCoE in ActionVol. 4 No

Lolita, Facebook, and the Third Space of Literacy Teacher Education

ERIC Educational Resources Information Center

Skerrett, Allison

2010-01-01

This article derives from an Adolescent Literacy course that had been designed to foster preservice teachers' knowledge, skills, and dispositions to teach from a multiliteracies perspective. At the course's conclusion, the author designed, and secured institutional IRB approval to conduct, a self-study of curriculum, teaching, and learning…

Pleasurable Pedagogies: "Reading Lolita in Tehran" and the Rhetoric of Empathy

ERIC Educational Resources Information Center

Kulbaga, Theresa A.

2008-01-01

In her audio essay for the the National Public Radio's series "This I Believe," Iranian-American author and professor Azar Nafisi celebrates the affective power of empathy. In the essay, Nafisi refers to actual people in Darfur, Afghanistan, Iraq, Algeria, Rwanda, and North Korea, but she turns to classic nineteenth-century American novel to…

78 FR 18340 - The Neiman Marcus Group, Inc.; Dr.Jays.com, Inc., Eminent, Inc.; Analysis of Proposed Consent...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-26

... heightened security screening. As a result, we encourage you to submit your comments online. To make sure...'' or ``Eminent, File No. 122 3065'' on your comment and file your comment online at https://ftcpublic... prefer to file your comment on paper, mail or deliver your comment to the following address: Federal...

Reading Lolita in Times of War: Women's Book Clubs and the Politics of Reception

ERIC Educational Resources Information Center

Burwell, Catherine

2007-01-01

In this article I argue that women's book clubs are significant sites for learning, dialogue and the accumulation of cultural capital, and that research on North American women's book clubs should be expanded to include studies of such groups' consumption of texts by and about women living in the Middle East. Using insights from transnational…

Ediacaran Seepage-related Cloudina-Microbialites from Southern Namibia

NASA Astrophysics Data System (ADS)

Reitner, Joachim, , Dr

2015-04-01

Little is known about the lifestyle of the calcified tube organisms of the Cloudina group. This late Proterozoic group, whose overall morphology slightly resembles modern calcified worm tubes, were the first animals with calcified skeletons. The modern seep-related vestimentiferan worm tubes of Escarpia are composed of chitin; in few cases we note the beginning of CaCO3 (aragonite) mineralisation on the chitin surfaces. The calcified skeleton of C. hartmannae exhibits a more complicated microstructure. The calcareous skeleton, which was probably originally aragonitic, appears to be produced by a probably enzymatically controlled biomineralisation. Seilacher (1999) reconstructed the Cloudina group as typical soft bottom dwellers. Some millimeter-sized C. riemkeae specimens are indeed common in soft micritic, lagoonal carbonates. However, we have observed large C. hartmannae tubes inside very large (5-8 meters high, 30-50 cm in diameter) pillar-like microbialites ("organ-pipes") from the Zaris Mountains/Zebra River (Omkyk Member, Kuibis Subgroup, Nama Group). These microbialiates have a complex structure. The inner portions of these microbialites are formed by large, cm-sized recrystallized aragonitic spherulites covered by calcified microbial matter exhibiting a typical thrombolitic structure. The outer portions of the microbialites exhibit a typical stromatolitic structure. These "organ-pipe" microbialites strongly resemble the modern ones known from Lake Van and Mono Lake. In both modern cases the microbialites grow in extremely alkaline water located at sites where Ca2+-rich ground water is seeping in the lake water. Geochemical data, from the still Sr-rich neomorphic former aragonitic spherulites and all other noted carbonate phases, suggest that the microbialites from the Zaris Mountains in Namibia formed under comparable conditions. Cloudina is very common within the thrombolitic portion of the microbialites and the occurrence is definitely autochthonous

Rearrangements of genes for the antigen receptor on T cells as markers of lineage and clonality in human lymphoid neoplasms.

PubMed

Waldmann, T A; Davis, M M; Bongiovanni, K F; Korsmeyer, S J

1985-09-26

The T alpha and T beta chains of the heterodimeric T-lymphocyte antigen receptor are encoded by separated DNA segments that recombine during T-cell development. We have used rearrangements of the T beta gene as a widely applicable marker of clonality in the T-cell lineage. We show that the T beta genes are used in both the T8 and T4 subpopulations of normal T cells and that Sézary leukemia, adult T-cell leukemia, and the non-B-lineage acute lymphoblastic leukemias are clonal expansions of T cells. Furthermore, circulating T cells from a patient with the T8-cell-predominantly lymphocytosis associated with granulocytopenia are shown to be monoclonal. Finally, the sensitivity and specificity of this tumor-associated marker have been exploited to monitor the therapy of a patient with adult T-cell leukemia. These unique DNA rearrangements provide insights into the cellular origin, clonality, and natural history of T-cell neoplasia.

Chemokines and skin diseases.

PubMed

Sugaya, Makoto

2015-04-01

Chemokines are small molecules that induce chemotaxis and activation of certain subsets of leukocytes. The expression patterns of chemokines and chemokine receptors are specific to certain organs and cells. Therefore, chemokines are important to elucidate the mechanism of organ-specific human diseases. CCL17 expressed by Langerhans cells, blood endothelial cells, and fibroblasts plays a key role in attracting Th2 cells and tumor cells of adult T-cell leukemia/lymphoma and mycosis fungoides/Sézary syndrome into the skin, developing various Th2-type inflammatory skin diseases as well as cutaneous lymphoma. CCL11 and CCL26 expressed by skin-resident cells, such as fibroblasts, blood endothelial cells, and keratinocytes, induce infiltration of CCR3-expressing cells such as Th2 cells and eosinophils. CCL11 may also serve as an autocrine as well as a paracrine in anaplastic large cell lymphoma. CX3CL1 expressed on blood endothelial cells leads to infiltration of CX3CR1(+) immune cells, such as mast cells, neutrophils, and macrophages, playing important roles in wound healing, tumor immunity, and vasculitis. Biologics targeting chemokines and their receptors are promising strategies for various skin diseases that are resistant to the current therapy.

Effects of external intermittency and mean shear on the spectral inertial-range exponent in a turbulent square jet

NASA Astrophysics Data System (ADS)

Zhang, J.; Xu, M.; Pollard, A.; Mi, J.

2013-05-01

This study investigates by experiment the dependence of the inertial-range exponent m of the streamwise velocity spectrum on the external intermittency factor γ (≡ the fraction of time the flow is fully turbulent) and the mean shear S in a turbulent square jet. Velocity measurements were made using hot-wire anemometry in the jet at 15 < x/De < 40, where De denotes the exit equivalent diameter, and for an exit Reynolds number of Re = 50 000. The Taylor microscale Reynolds number Rλ varies from about 70 to 450 in the present study. The TERA (turbulent energy recognition algorithm) method proposed by Falco and Gendrich [in Near-Wall Turbulence: 1988 Zoran Zariç Memorial Conference, edited by S. J. Kline and N. H. Afgan (Hemisphere Publishing Corp., Washington, DC, 1990), pp. 911-931] is discussed and applied to estimate the intermittency factor from velocity signals. It is shown that m depends strongly on γ but negligibly on S. More specifically, m varies with γ following m=mt+(lnγ-0.0173)1/2, where mt denotes the spectral exponent found in fully turbulent regions.

Pagetoid reticulosis (Woringer-Kolopp disease). An ultrastructural and immunocytological study.

PubMed

Takahashi, H; Takahashi, K; Tanno, K; Iijima, S

1982-05-01

Histopathological, immunocytological and ultrastructural observations are reported in the first case of pagetoid reticulosis (Woringer-Kolopp disease) in Japan. The patient was a 61-year-old woman with multiple skin lesions running a chronic and apparently benign clinical course. Histology of the skin biopsies revealed typical pagetoid appearance of the epidermis due to intraepidermal infiltration of abnormal cells. Ultrastructural investigation showed that the intraepidermal abnormal cells were classified into mycosis fungoides cells, Sézary cells, lymphoblast-like cells, and large blastoid cells and that the mycosis fungoides cells were a major cell population. Intermediate or transitional cells were found between these cells and large blastoid cells were mostly situated in the basal cell layer. By the rosetting assays of the free cell suspensions prepared from the epidermis of the biopsied skin lesions, 93% of the suspended cells were positive for spontaneous rosette formation with sheep erythrocytes. The immunoperoxidase technique demonstrated no cytoplasmic immunoglobulins in almost all the intraepidermal abnormal cells. These results indicate that the intraepidermal abnormal cells are T-lymphocytes. Thus, it is concluded that the present case is a cutaneous T-cell lymphoma of low-grade malignancy showing a prominent epidermotropism. This case is the first description of the disease in Japan.

Apoptosis Induction and Gene Expression Profile Alterations of Cutaneous T-Cell Lymphoma Cells following Their Exposure to Bortezomib and Methotrexate

PubMed Central

Kontsioti, Frieda; Konsta, Eugene; Vikentiou, Miriam; Spathis, Aris; Papageorgiou, Sotiris; Vasilatou, Diamantina; Gkontopoulos, Konstantinos; Mpazani, Efthimia; Karakitsos, Petros; Rigopoulos, Dimitrios; Dimitriadis, George

2017-01-01

Mycosis fungoides (MF) and its leukemic variant Sézary syndrome (SS) comprise the majority of CTCL, a heterogenous group of non-Hodgkins lymphomas involving the skin. The CTCL’s resistance to chemotherapy and the lack of full understanding of their pathogenesis request further investigation. With the view of a more targeted therapy, we evaluated in vitro the effectiveness of bortezomib and methotrexate, as well as their combination in CTCL cell lines, regarding apoptosis induction. Our data are of clinical value and indicate that the bortezomib/methotrexate combinational therapy has an inferior impact on the apoptosis of CTCL compared to monotherapy, with bortezomib presenting as the most efficient treatment option for SS and methotrexate for MF. Using PCR arrays technology, we also investigated the alterations in the expression profile of genes related to DNA repair pathways in CTCL cell lines after treatment with bortezomib or methotrexate. We found that both agents, but mostly bortezomib, significantly deregulate a large number of genes in SS and MF cell lines, suggesting another pathway through which these agents could induce apoptosis in CTCL. Finally, we show that SS and MF respond differently to treatment, verifying their distinct nature and further emphasizing the need for discrete treatment approaches. PMID:28107479

Academic Radiologist Subspecialty Identification Using a Novel Claims-Based Classification System.

PubMed

Rosenkrantz, Andrew B; Wang, Wenyi; Hughes, Danny R; Ginocchio, Luke A; Rosman, David A; Duszak, Richard

2017-06-01

The objective of the present study is to assess the feasibility of a novel claims-based classification system for payer identification of academic radiologist subspecialties. Using a categorization scheme based on the Neiman Imaging Types of Service (NITOS) system, we mapped the Medicare Part B services billed by all radiologists from 2012 to 2014, assigning them to the following subspecialty categories: abdominal imaging, breast imaging, cardiothoracic imaging, musculoskeletal imaging, nuclear medicine, interventional radiology, and neuroradiology. The percentage of subspecialty work relative value units (RVUs) to total billed work RVUs was calculated for each radiologist nationwide. For radiologists at the top 20 academic departments funded by the National Institutes of Health, those percentages were compared with subspecialties designated on faculty websites. NITOS-based subspecialty assignments were also compared with the only radiologist subspecialty classifications currently recognized by Medicare (i.e., nuclear medicine and interventional radiology). Of 1012 academic radiologists studied, the median percentage of Medicare-billed NITOS-based subspecialty work RVUs matching the subspecialty designated on radiologists' own websites ranged from 71.3% (for nuclear medicine) to 98.9% (for neuroradiology). A NITOS-based work RVU threshold of 50% correctly classified 89.8% of radiologists (5.9% were not mapped to any subspecialty; subspecialty error rate, 4.2%). In contrast, existing Medicare provider codes identified only 46.7% of nuclear medicine physicians and 39.4% of interventional radiologists. Using a framework based on a recently established imaging health services research tool that maps service codes based on imaging modality and body region, Medicare claims data can be used to consistently identify academic radiologists by subspecialty in a manner not possible with the use of existing Medicare physician specialty identifiers. This method may facilitate

Brentuximab vedotin for treatment of non-Hodgkin lymphomas: A systematic review

PubMed Central

Berger, Garrett K.; McBride, Ali; Lawson, Stephanie; Royball, Kelsey; Yun, Seongseok; Gee, Kevin; Riaz, Irbaz Bin; Saleh, Ahlam A.; Puvvada, Soham; Anwer, Faiz

2016-01-01

Background Brentuximab vedotin (BV) is an antibody-drug conjucate (ADC) comprising a CD30-directed antibody, conjugated to the microtubule-disrupting agent MMAE via a protease cleavable linker. BV is FDA approved for use in relapsed classical Hodgkin lymphoma (HL) and relapsed systemic anaplastic large cell lymphoma (sALCL). There are multiple publications for its utility in other malignancies such as diffuse large B-cell lymphoma (DLBCL), mycosis fungoides (MF), Sézary syndrome (SS), T-cell lymphomas (TCL), primary mediastinal lymphoma (PMBL), and post-transplant lymphoproliferative disorders (PTLD). We believe that BV could potentially provide a strong additional treatment option for patients suffering from NHL. Objective Perform a systematic review on the use of BV in non-Hodgkin lymphoma (NHL) and other CD30+ malignancies in humans. Data sources We searched various databases including PubMed (1946–2015), EMBASE (1947–2015), and Cochrane Central Register of Controlled Trials (1898–2015). Eligibility criteria Inclusion criteria specified all studies and case reports of NHLs in which BV therapy was administered. Included studies A total of 28 articles met these criteria and are summarized in this manuscript. Conclusion Our findings indicate that BV induces a variety of responses, largely positive in nature and variable between NHL subtypes. With additional, properly powered prospective studies, BV may prove to be a strong candidate in the treatment of various CD30+ malignancies. PMID:28010897

Lack of T-cell receptor-induced signaling is crucial for CD95 ligand up-regulation and protects cutaneous T-cell lymphoma cells from activation-induced cell death.

PubMed

Klemke, Claus-Detlev; Brenner, Dirk; Weiss, Eva-Maria; Schmidt, Marc; Leverkus, Martin; Gülow, Karsten; Krammer, Peter H

2009-05-15

Restimulation of previously activated T cells via the T-cell receptor (TCR) leads to activation-induced cell death (AICD), which is, at least in part, dependent on the death receptor CD95 (APO-1, FAS) and its natural ligand (CD95L). Here, we characterize cutaneous T-cell lymphoma (CTCL) cells (CTCL tumor cell lines and primary CTCL tumor cells from CTCL patients) as AICD resistant. We show that CTCL cells have elevated levels of the CD95-inhibitory protein cFLIP. However, cFLIP is not responsible for CTCL AICD resistance. Instead, our data suggest that reduced TCR-proximal signaling in CTCL cells is responsible for the observed AICD resistance. CTCL cells exhibit no PLC-gamma1 activity, resulting in an impaired Ca(2+)release and reduced generation of reactive oxygen species upon TCR stimulation. Ca(2+) and ROS production are crucial for up-regulation of CD95L and reconstitution of both signals resulted in AICD sensitivity of CTCL cells. In accordance with these data, CTCL tumor cells from patients with Sézary syndrome do not up-regulate CD95L upon TCR-stimulation and are therefore resistant to AICD. These results show a novel mechanism of AICD resistance in CTCL that could have future therapeutic implications to overcome apoptosis resistance in CTCL patients.

Romidepsin for the treatment of relapsed/refractory cutaneous T-cell lymphoma (mycosis fungoides/Sézary syndrome): Use in a community setting.

PubMed

Reddy, Sunil A

2016-10-01

Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of rare non-Hodgkin lymphomas that arise in the skin. In advanced stages, CTCL becomes systemic and is associated with poor prognosis. Diagnosis of CTCL and treatment of early-stage disease with topical therapies often occurs under the care of a dermatologist. Community oncologists see few patients with CTCL due to direct referrals from dermatologists to academic or lymphoma specialty centers. However, some patients will continue to be managed in a community setting. Currently there is no evidence-based stepwise algorithm for treatment of patients with CTCL, and guidelines suggest a wide range of systemic therapies, including biologics, targeted agents, and more traditional chemotherapies. To provide optimal care in a community setting, oncologists must become familiar with newer nonchemotherapeutic treatment options. This review highlights romidepsin, a histone deacetylase inhibitor approved for the treatment of patients with CTCL who have received ≥1 prior systemic therapy. Copyright © 2016 The Author. Published by Elsevier Ireland Ltd.. All rights reserved.

Phase II Multi-Institutional Trial of the Histone Deacetylase Inhibitor Romidepsin As Monotherapy for Patients With Cutaneous T-Cell Lymphoma

PubMed Central

Piekarz, Richard L.; Frye, Robin; Turner, Maria; Wright, John J.; Allen, Steven L.; Kirschbaum, Mark H.; Zain, Jasmine; Prince, H. Miles; Leonard, John P.; Geskin, Larisa J.; Reeder, Craig; Joske, David; Figg, William D.; Gardner, Erin R.; Steinberg, Seth M.; Jaffe, Elaine S.; Stetler-Stevenson, Maryalice; Lade, Stephen; Fojo, A. Tito; Bates, Susan E.

2009-01-01

Purpose Romidepsin (depsipeptide or FK228) is a member of a new class of antineoplastic agents active in T-cell lymphoma, the histone deacetylase inhibitors. On the basis of observed responses in a phase I trial, a phase II trial of romidepsin in patients with T-cell lymphoma was initiated. Patients and Methods The initial cohort was limited to patients with cutaneous T-cell lymphoma (CTCL), or subtypes mycosis fungoides or Sézary syndrome, who had received no more than two prior cytotoxic regimens. There were no limits on other types of therapy. Subsequently, the protocol was expanded to enroll patients who had received more than two prior cytotoxic regimens. Results Twenty-seven patients were enrolled onto the first cohort, and a total of 71 patients are included in this analysis. These patients had undergone a median of four prior treatments, and 62 patients (87%) had advanced-stage disease (stage IIB, n = 15; stage III, n= 6; or stage IV, n = 41). Toxicities included nausea, vomiting, fatigue, and transient thrombocytopenia and granulocytopenia. Pharmacokinetics were evaluated with the first administration of romidepsin. Complete responses were observed in four patients, and partial responses were observed in 20 patients for an overall response rate of 34% (95% CI, 23% to 46%). The median duration of response was 13.7 months. Conclusion The histone deacetylase inhibitor romidepsin has single-agent clinical activity with significant and durable responses in patients with CTCL. PMID:19826128

Progression of undiagnosed cutaneous lymphoma after anti-tumor necrosis factor-alpha therapy.

PubMed

Martinez-Escala, Maria Estela; Posligua, Alba L; Wickless, Heather; Rutherford, Audrey; Sable, Kimberly A; Rubio-Gonzalez, Belen; Zhou, Xiaolong A; Kaplan, Jason B; Pro, Barbara; Choi, Jaehyuk; Querfeld, Christiane; Rosen, Steven T; Guitart, Joan

2018-06-01

Cutaneous lymphoma diagnosed after anti-tumor necrosis factor-α therapy (anti-TNF-α) has been reported in the literature, yet a clear link between both events remains elusive. To review our experience with cutaneous lymphoma diagnosed during or after the use of anti-TNF-α therapies. This is a multicenter retrospective study and a literature review. A total of 22 cases, including 20 cutaneous T-cell lymphomas (CTCLs) and 2 cutaneous B-cell lymphomas, were identified. In the CTCL group, 75% of the patients received an anti-TNF-α agent for a presumed inflammatory skin condition. Mycosis fungoides and Sézary syndrome were the most common subtypes of CTCL diagnosed. Advanced disease (stage IIB to IVA) was commonly seen at time of diagnosis and required aggressive therapy, including stem cell transplant in 3 patients; 2 patients in whom cutaneous B-cell lymphomas was diagnosed had an indolent course. A total of 31 cases were gathered from a literature search. This is a retrospective study. Our findings suggest that the disease of most of the identified patients was misdiagnosed as psoriasis or eczema; therefore, a comprehensive morphologic and molecular review of skin biopsy specimens and peripheral blood samples should be considered before initiation of anti-TNF-α therapy in patients with poorly defined dermatitis or atypical presentations of psoriasis. Copyright © 2018 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

Low-dose (10-Gy) total skin electron beam therapy for cutaneous T-cell lymphoma: an open clinical study and pooled data analysis.

PubMed

Kamstrup, Maria R; Gniadecki, Robert; Iversen, Lars; Skov, Lone; Petersen, Peter Meidahl; Loft, Annika; Specht, Lena

2015-05-01

Cutaneous T-cell lymphomas (CTCLs) are dominated by mycosis fungoides (MF) and Sézary syndrome (SS), and durable disease control is a therapeutic challenge. Standard total skin electron beam therapy (TSEBT) is an effective skin-directed therapy, but the possibility of retreatments is limited to 2 to 3 courses in a lifetime due to skin toxicity. This study aimed to determine the clinical effect of low-dose TSEBT in patients with MF and SS. In an open clinical study, 21 patients with MF/SS stages IB to IV were treated with low-dose TSEBT over <2.5 weeks, receiving a total dose of 10 Gy in 10 fractions. Data from 10 of these patients were published previously but were included in the current pooled data analysis. Outcome measures were response rate, duration of response, and toxicity. The overall response rate was 95% with a complete cutaneous response or a very good partial response rate (<1% skin involvement with patches or plaques) documented in 57% of the patients. Median duration of overall cutaneous response was 174 days (5.8 months; range: 60-675 days). TSEBT-related acute adverse events (grade 1 or 2) were observed in 60% of patients. Low-dose (10-Gy) TSEBT offers a high overall response rate and is relatively safe. With this approach, reirradiation at times of relapse or progression is likely to be less toxic than standard dose TSEBT. It remains to be established whether adjuvant and combination treatments can prolong the beneficial effects of low-dose TSEBT. Copyright © 2015 Elsevier Inc. All rights reserved.

Doxycycline is an NF-κB inhibitor that induces apoptotic cell death in malignant T-cells

PubMed Central

Alexander-Savino, Carolina V.; Hayden, Matthew S.; Richardson, Christopher; Zhao, Jiyong; Poligone, Brian

2016-01-01

Cutaneous T-cell Lymphoma (CTCL) is a rare non-Hodgkin's lymphoma that can affect the skin, blood, and lymph nodes, and can metastasize at late stages. Novel therapies that target all affected disease compartments and provide longer lasting responses while being safe are needed. One potential therapeutic target is NF-λB, a regulator of immune responses and an important participant in carcinogenesis and cancer progression. As a transcription factor, NF-λB targets genes that promote cell proliferation and survival. Constitutive or aberrant activation of NF-λB is encountered in many types of cancer, including CTCL. Recently, while analyzing gene-expression profiles of a variety of small molecule compounds that target NF-λB, we discovered the tetracycline family of antibiotics, including doxycycline, to be potent inhibitors of the NF-λB pathway. Doxycycline is well-tolerated, safe, and inexpensive; and is commonly used as an antibiotic and anti-inflammatory for the treatment a multitude of medical conditions. In our current study, we show that doxycycline induces apoptosis in a dose dependent manner in multiple different cell lines from patients with the two most common subtypes of CTCL, Mycosis Fungoides (MF) and Sézary Syndrome (SS). Similar results were found using primary CD4+ T cells from a patient with SS. Doxycycline inhibits TNF induced NF-λB activation and reduces expression of NF-λB dependent anti-apoptotic proteins, such as BCL2α. Furthermore, we have identified that doxycycline induces apoptosis through reactive oxygen species. PMID:27732942

Doxycycline is an NF-κB inhibitor that induces apoptotic cell death in malignant T-cells.

PubMed

Alexander-Savino, Carolina V; Hayden, Matthew S; Richardson, Christopher; Zhao, Jiyong; Poligone, Brian

2016-11-15

Cutaneous T-cell Lymphoma (CTCL) is a rare non-Hodgkin's lymphoma that can affect the skin, blood, and lymph nodes, and can metastasize at late stages. Novel therapies that target all affected disease compartments and provide longer lasting responses while being safe are needed. One potential therapeutic target is NF-κB, a regulator of immune responses and an important participant in carcinogenesis and cancer progression. As a transcription factor, NF-κB targets genes that promote cell proliferation and survival. Constitutive or aberrant activation of NF-κB is encountered in many types of cancer, including CTCL.Recently, while analyzing gene-expression profiles of a variety of small molecule compounds that target NF-κB, we discovered the tetracycline family of antibiotics, including doxycycline, to be potent inhibitors of the NF-κB pathway. Doxycycline is well-tolerated, safe, and inexpensive; and is commonly used as an antibiotic and anti-inflammatory for the treatment a multitude of medical conditions.In our current study, we show that doxycycline induces apoptosis in a dose dependent manner in multiple different cell lines from patients with the two most common subtypes of CTCL, Mycosis Fungoides (MF) and Sézary Syndrome (SS). Similar results were found using primary CD4+ T cells from a patient with SS. Doxycycline inhibits TNF induced NF-κB activation and reduces expression of NF-κB dependent anti-apoptotic proteins, such as BCL2α. Furthermore, we have identified that doxycycline induces apoptosis through reactive oxygen species.

CCR4 is expressed on infiltrating cells in lesional skin of early mycosis fungoides and atopic dermatitis.

PubMed

Sugaya, Makoto; Morimura, Sohshi; Suga, Hiraku; Kawaguchi, Makiko; Miyagaki, Tomomitsu; Ohmatsu, Hanako; Fujita, Hideki; Sato, Shinichi

2015-06-01

CCR4 is expressed on tumor cells of mycosis fungoides (MF) and Sézary syndrome (SS). In MF, most infiltrating cells in patches and plaques express CXCR3, while tumor cells express CCR4 in advanced stages. Poteligeo Test IHC (CCR4 staining kit) is a newly developed staining kit that can examine the presence of CCR4 expressed on tumor cells of adult T-cell leukemia/lymphoma, peripheral T-cell lymphoma and cutaneous T-cell lymphoma before treatment of anti-CCR4 antibody using paraffin-embedded samples. In this study, we analyzed CCR4 expression in lesional skin of MF, SS, atopic dermatitis (AD) and psoriasis with this new kit. CCR4 was expressed on infiltrating cells in lesional skin of patch, plaque, tumor MF and SS, and the number of positive cells increased as the disease progressed. Immunohistochemistry with frozen sections also showed some positive cells scattered in the dermis, although the quality was not high enough to quantify positive cells. There were significant positive correlations between CCR4(+) cells and serum lactate dehydrogenase levels. Interestingly, CCR4(+) cells were also detected in AD skin, whose number was larger than that in psoriatic skin. Previous studies showed only scattered CCR4(+) cells in skin samples by standard immunohistochemical staining. The new, sensitive CCR4 staining kit has revealed that CCR4 is expressed on infiltrating cells in lesional skin of early MF and AD as well as advanced MF and SS. These cells can be therapeutic targets for patients who are resistant to standard treatments. © 2015 Japanese Dermatological Association.

Spectrophotometric and computerized evaluation of tooth bleaching employing 10 different home-bleaching procedures: In-vitro study

PubMed Central

Peskersoy, Cem; Tetik, Ayhan; Ozturk, Veli Ozgen; Gokay, Necmi

2014-01-01

Objective: The aim of this in-vitro study was to evaluate the efficacy of bleaching products, determine the applicability and validation of the measurement methods. Materials and Methods: Freshly extracted 110 human incisor teeth were stained with whole blood and hemolysate solution prior to the application of 10 different home-bleaching products. Spectrophotometric measurements of the tooth shades were performed for each specimen before and after bleaching at the 1st, 3rd, 7th, and 14 days. Differences in lightness (Δl), chroma (Δc), hue (Δh) values and shade changes were measured to evaluate process. Computerized digital imaging analyses to determine the color changes were performed with Photoshop CS4 software (Adobe, San Jose, CA, USA). Statistical analyses were performed with analysis of variance, Scheffe and Tukey tests. Results: In all of the test groups regardless of the material used, a significant increase in lightness and hue, and decrease of chroma were observed, as compared to the control group. After recommended bleaching applications, Δl and Δh values respectively increased in group Zaris White and Brite (ZWB) and group Pola Night and Δc values showed significant decrease in groups ZWB and Rembrandt REM3 (P < 0.05). At the end of the procedure both spectrophotometric and digital imaging analysis showed ZWB was the most effective product among the others while Yotuel and Happy Smile were the least (P < 0.05). Conclusions: Home-bleaching systems showed slower but almost permanent bleaching effect likewise office-based methods. Both software and spectrophotometric analyses have advantages such as evaluating the results objectively and numerically, also treatment outcomes could be preserved. PMID:25512738

Low-Dose (10-Gy) Total Skin Electron Beam Therapy for Cutaneous T-Cell Lymphoma: An Open Clinical Study and Pooled Data Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kamstrup, Maria R., E-mail: mkam0004@bbh.regionh.dk; Gniadecki, Robert; Iversen, Lars

2015-05-01

Purpose: Cutaneous T-cell lymphomas (CTCLs) are dominated by mycosis fungoides (MF) and Sézary syndrome (SS), and durable disease control is a therapeutic challenge. Standard total skin electron beam therapy (TSEBT) is an effective skin-directed therapy, but the possibility of retreatments is limited to 2 to 3 courses in a lifetime due to skin toxicity. This study aimed to determine the clinical effect of low-dose TSEBT in patients with MF and SS. Methods and Materials: In an open clinical study, 21 patients with MF/SS stages IB to IV were treated with low-dose TSEBT over <2.5 weeks, receiving a total dose of 10 Gymore » in 10 fractions. Data from 10 of these patients were published previously but were included in the current pooled data analysis. Outcome measures were response rate, duration of response, and toxicity. Results: The overall response rate was 95% with a complete cutaneous response or a very good partial response rate (<1% skin involvement with patches or plaques) documented in 57% of the patients. Median duration of overall cutaneous response was 174 days (5.8 months; range: 60-675 days). TSEBT-related acute adverse events (grade 1 or 2) were observed in 60% of patients. Conclusions: Low-dose (10-Gy) TSEBT offers a high overall response rate and is relatively safe. With this approach, reirradiation at times of relapse or progression is likely to be less toxic than standard dose TSEBT. It remains to be established whether adjuvant and combination treatments can prolong the beneficial effects of low-dose TSEBT.« less

Primary cutaneous T-cell lymphoma: experience from the Peruvian National Cancer Institute*

PubMed Central

Ruiz, Rosana; Morante, Zaida; Mantilla, Raul; Mas, Luis; Casanova, Luis; Gomez, Henry L.

2017-01-01

Background Primary cutaneous T-cell lymphomas constitute a heterogeneous and rare group of diseases with regional particularities in Latin America. Objective To determine the clinicopathological features, relative frequency and survival among patients from a Peruvian institution. Methods Primary cutaneous T-cell lymphomas were defined based on the absence of extracutaneous disease at diagnosis. Classification was performed following the 2008 World Health Organization Classification of Neoplasms of the Hematopoietic and Lymphoid tissues. Risk groups were established according to the 2005 World Health Organization-EORTC classification for cutaneous lymphomas. Data of patients admitted between January 2008 and December 2012 were analyzed. Results 74 patients were included. Mean age was 49.5 years. In order of frequency, diagnoses were: mycosis fungoides (40.5%), peripheral T-cell lymphoma not otherwise specified (22.95%), adult T-cell lymphoma/leukemia (18.9%), CD30+ lymphoproliferative disorders (6.8%), hydroa vacciniforme-like lymphoma (5.4%), extranodal NK/T-cell lymphoma (4.1%) and Sézary syndrome (1.4%). Predominant clinical patterns were observed across different entities. Mycosis fungoides appeared mainly as plaques (93%). Peripheral T-cell lymphoma not otherwise specified and adult T-cell lymphoma/leukemia presentation was polymorphic. All patients with hydroa vacciniforme-like lymphoma presented with facial edema. All cases of extranodal NK/T-cell lymphoma appeared as ulcerated nodules/tumors. Disseminated cutaneous involvement was found in 71.6% cases. Forty-six percent of patients were alive at 5 years. Five-year overall survival was 76.4% and 19.2%, for indolent and high-risk lymphomas, respectively (p<0.05). High risk group (HR: 4.6 [2.08-10.18]) and increased DHL level (HR: 3.2 [1.57-6.46]) emerged as prognostic factors for survival. Study limitations Small series. Conclusion Primary cutaneous T-cell lymphomas other than mycosis fungoides or CD30

Allogeneic stem cell transplantation for advanced cutaneous T-cell lymphomas: a study from the French Society of Bone Marrow Transplantation and French Study Group on Cutaneous Lymphomas

PubMed Central

de Masson, Adèle; Beylot-Barry, Marie; Bouaziz, Jean-David; de Latour, Régis Peffault; Aubin, François; Garciaz, Sylvain; d’Incan, Michel; Dereure, Olivier; Dalle, Stéphane; Dompmartin, Anne; Suarez, Felipe; Battistella, Maxime; Vignon-Pennamen, Marie-Dominique; Rivet, Jacqueline; Adamski, Henri; Brice, Pauline; François, Sylvie; Lissandre, Séverine; Turlure, Pascal; Wierzbicka-Hainaut, Ewa; Brissot, Eolia; Dulery, Rémy; Servais, Sophie; Ravinet, Aurélie; Tabrizi, Reza; Ingen-Housz-Oro, Saskia; Joly, Pascal; Socié, Gérard; Bagot, Martine

2014-01-01

The treatment of advanced stage primary cutaneous T-cell lymphomas remains challenging. In particular, large-cell transformation of mycosis fungoides is associated with a median overall survival of two years for all stages taken together. Little is known regarding allogeneic hematopoietic stem cell transplantation in this context. We performed a multicenter retrospective analysis of 37 cases of advanced stage primary cutaneous T-cell lymphomas treated with allogeneic stem cell transplantation, including 20 (54%) transformed mycosis fungoides. Twenty-four patients (65%) had stage IV disease (for mycosis fungoides and Sézary syndrome) or disseminated nodal or visceral involvement (for non-epidermotropic primary cutaneous T-cell lymphomas). After a median follow up of 29 months, 19 patients experienced a relapse, leading to a 2-year cumulative incidence of relapse of 56% (95%CI: 0.38–0.74). Estimated 2-year overall survival was 57% (95%CI: 0.41–0.77) and progression-free survival 31% (95%CI: 0.19–0.53). Six of 19 patients with a post-transplant relapse achieved a subsequent complete remission after salvage therapy, with a median duration of 41 months. A weak residual tumor burden before transplantation was associated with increased progression-free survival (HR=0.3, 95%CI: 0.1–0.8; P=0.01). The use of antithymocyte globulin significantly reduced progression-free survival (HR=2.9, 95%CI: 1.3–6.2; P=0.01) but also transplant-related mortality (HR=10−7, 95%CI: 4.10−8–2.10−7; P<0.001) in univariate analysis. In multivariate analysis, the use of antithymocyte globulin was the only factor significantly associated with decreased progression-free survival (P=0.04). Allogeneic stem cell transplantation should be considered in advanced stage primary cutaneous T-cell lymphomas, including transformed mycosis fungoides. PMID:24213148

No genetic evidence for involvement of Deltaretroviruses in adult patients with precursor and mature T-cell neoplasms

PubMed Central

Burmeister, Thomas; Schwartz, Stefan; Hummel, Michael; Hoelzer, Dieter; Thiel, Eckhard

2007-01-01

Background The Deltaretrovirus genus comprises viruses that infect humans (HTLV), various simian species (STLV) and cattle (BLV). HTLV-I is the main causative agent in adult T-cell leukemia in endemic areas and some of the simian T-cell lymphotropic viruses have been implicated in the induction of malignant lymphomas in their hosts. BLV causes enzootic bovine leukosis in infected cattle or sheep. During the past few years several new Deltaretrovirus isolates have been described in various primate species. Two new HTLV-like viruses in humans have recently been identified and provisionally termed HTLV-III and HTLV-IV. In order to identify a broad spectrum of Deltaretroviruses by a single PCR approach we have established a novel consensus PCR based on nucleotide sequence data obtained from 42 complete virus isolates (HTLV-I/-II, STLV-I/-II/-III, BLV). The primer sequences were based on highly interspecies-conserved virus genome regions. We used this PCR to detect Deltaretroviruses in samples from adult patients with a variety of rare T-cell neoplasms in Germany. Results The sensitivity of the consensus PCR was at least between 10-2 and 10-3 with 100% specificity as demonstrated by serial dilutions of cell lines infected with either HTLV-I, HTLV-II or BLV. Fifty acute T-cell lymphoblastic leukemia (T-ALL) samples and 33 samples from patients with various rare mature T-cell neoplasms (T-PLL, Sézary syndrome and other T-NHL) were subsequently investigated. There were no cases with HTLV-I, HTLV-II or any other Deltaretroviruses. Conclusion The results rule out a significant involvement of HTLV-I or HTLV-II in these disease entities and show that other related Deltaretroviruses are not likely to be involved. The newly established Deltaretrovirus PCR may be a useful tool for identifying new Deltaretroviruses. PMID:17284327

Anti-ATLA (antibody to adult T-cell leukemia virus-associated antigen), highly positive in OKT4-positive mature T-cell malignancies.

PubMed

Tobinai, K; Nagai, M; Setoya, T; Shibata, T; Minato, K; Shimoyama, M

1983-01-01

Serum or plasma specimens from 252 patients with lymphoid malignancies were screened for reactivity with adult T-cell leukemia virus-associated antigen (ATLA), and the relationship between the immunologic phenotype of the tumor cells and ATLA reactivity was determined. Anti-ATLA antibodies were found in 24 (29.3%) of 82 patients with T-cell malignancy. In contrast, the antibodies were found in none of the 106 patients with B-cell malignancy and only rarely in patients with other lymphoid malignancies without blood transfusions. Among the patients with T-cell malignancy, anti-ATLA antibodies were found in 23 (45.1%) of the 51 patients with OKT4-positive mature T-cell (inducer/helper T-cell) malignancy, but in none of the patients with T-cell malignancy of pre-T, thymic T-cell or OKT8-positive mature T-cell (suppressor/cytotoxic T-cell) phenotype. Furthermore, among the OKT4-positive mature T-cell malignancies, the antibodies were found in 16 (84.2%) of 19 patients with ATL and in 5 (27.8%) of 18 patients with mature (peripheral) T-cell lymphoma, in none of four with typical T-chronic lymphocytic leukemia, in one of nine with mycosis fungoides and in the one patient with small-cell variant of Sézary's syndrome. These results suggest that anti-ATLA positive T-cell malignancies with OKT4-positive mature T-cell phenotype must be the same disease, because it is highly possible that they have the same etiology and the same cellular origin. In the atypical cases, it seems necessary to demonstrate monoclonal integration of proviral DNA of ATLV or HTLV into the tumor cells in order to establish the final diagnosis of ATL.

Outcome of Patients Treated With a Single-Fraction Dose of Palliative Radiation for Cutaneous T-Cell Lymphoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thomas, Tarita O.; Agrawal, Priya; Guitart, Joan

2013-03-01

Purpose: Cutaneous T-cell lymphoma (CTCL) is a radiosensitive tumor. Presently, treatment with radiation is given in multiple fractions. The current literature lacks data that support single-fraction treatment for CTCL. This retrospective review assesses the clinical response in patients treated with a single fraction of radiation. Methods and Materials: This study reviewed the records of 58 patients with CTCL, primarily mycosis fungoides, treated with a single fraction of palliative radiation therapy (RT) between October 1991 and January 2011. Patient and tumor characteristics were reviewed. Response rates were compared using Fisher's exact test and multiple logistic regressions. Survival rates were determined usingmore » the Kaplan-Meier method. Cost-effectiveness analysis was performed to assess the cost of a single vs a multifractionated treatment regimen. Results: Two hundred seventy individual lesions were treated, with the majority (97%) treated with ≥700 cGy; mean follow-up was 41.3 months (range, 3-180 months). Response rate by lesion was assessed, with a complete response (CR) in 255 (94.4%) lesions, a partial response in 10 (3.7%) lesions, a partial response converted to a CR after a second treatment in 4 (1.5%) lesions, and no response in 1 (0.4%) lesion. The CR in lower extremity lesions was lower than in other sites (P=.0016). Lesions treated with photons had lower CR than those treated with electrons (P=.017). Patients with lesions exhibiting large cell transformation and tumor morphology had lower CR (P=.04 and P=.035, respectively). Immunophenotype did not impact response rate (P=.23). Overall survival was significantly lower for patients with Sézary syndrome (P=.0003) and erythroderma (P<.0001). The cost of multifractionated radiation was >200% higher than that for single-fraction radiation. Conclusions: A single fraction of 700 cGy-800 cGy provides excellent palliation for CTCL lesions and is cost effective and convenient for the patient.« less

The Atmospheric River Observatory: an example of a meteorological application of real-time GNSS data.

NASA Astrophysics Data System (ADS)

Gutman, S. I.

2011-12-01

moisture content of atmospheric rivers at all stages of their evolution. GNSS observations offshore are used to calibrate satellite sensors and validate data products. Onshore, GNSS observations provide continuous monitoring of the upslope component of the moisture flux that is highly correlated with heavy precipitation. Assimilated into numerical weather prediction models in conjunction with Doppler radar wind profiler data, GNSS observations are responsible for significant improvements in objective short-term relative humidity and heavy precipitation forecasts (Neiman et al. 2009). Nonetheless, the greatest remaining challenge is to predicting rainfall totals in these events as models struggle with the details of the location, duration and timing of AR's as they make landfall.

Total Skin Electron Beam for Primary Cutaneous T-cell Lymphoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elsayad, Khaled; Kriz, Jan; Moustakis, Christos

Purpose: Recent trials with low-dose total skin electron beam (TSEB) therapy demonstrated encouraging results for treating primary cutaneous T-cell lymphoma (PCTCL). In this study, we assessed the feasibility of different radiation doses and estimated survival rates of different pathologic entities and stages. Methods and Materials: We retrospectively identified 45 patients with PCTCL undergoing TSEB therapy between 2000 and 2015. Clinical characteristics, treatment outcomes, and toxicity were assessed. Results: A total of 49 courses of TSEB therapy were administered to the 45 patients. There were 26 pathologically confirmed cases of mycosis fungoides (MF) lymphoma, 10 cases of Sézary syndrome (SS), andmore » 9 non-MF/SS PCTCL patients. In the MF patients, the overall response rate (ORR) was 92% (50% complete remission [CR]), 70% ORR in SS patients (50% CR), and 89% ORR in non-MF/SS patients (78% CR). The ORR for MF/SS patients treated with conventional dose (30-36 Gy) regimens was 92% (63% CR) and 75% (25% CR) for low-dose (<30-Gy) regimens (P=.09). In MF patients, the overall survival (OS) was 77 months with conventional dose regimens versus 14 months with low-dose regimens (P=.553). In SS patients, the median OS was 48 versus 16 months (P=.219), respectively. Median event-free survival (EFS) for MF in conventional dose patients versus low-dose patients was 15 versus 8 months, respectively (P=.264) and 19 versus 3 months for SS patients (P=.457). Low-dose regimens had shorter treatment time (P=.009) and lower grade 2 adverse events (P=.043). A second TSEB course was administered in 4 MF patients with 100% ORR. There is a possible prognostic impact of supplemental/boost radiation (P<.001); adjuvant treatment (P<.001) and radiation tolerability (P=.021) were detected. Conclusions: TSEB therapy is an efficacious treatment modality in the treatment of several forms of cutaneous T-cell lymphoma. There is a nonsignificant trend to higher and longer clinical

Results of a Phase II Trial of Brentuximab Vedotin for CD30+ Cutaneous T-Cell Lymphoma and Lymphomatoid Papulosis.

PubMed

Duvic, Madeleine; Tetzlaff, Michael T; Gangar, Pamela; Clos, Audra L; Sui, Dawen; Talpur, Rakhshandra

2015-11-10

Brentuximab vedotin, a monoclonal antibody (cAC10) conjugated to monomethyl auristatin E, targets CD30(+) receptors. This phase II open-label trial was conducted to evaluate safety and efficacy in CD30(+) cutaneous T-cell lymphomas. Forty-eight patients with CD30(+) lymphoproliferative disorders or mycosis fungoides (MF) received an infusion of 1.8 mg/kg every 21 days. Forty-eight evaluable patients (22 women and 26 men; median age, 59.5 years) had an overall response rate of 73% (95% CI, 60% to 86%; 35 of 48 patients) and complete response rate of 35% (95% CI, 22% to 49%; 17 of 48 patients). Fifteen (54%; 95% CI, 31% to 59%) of 28 patients with MF responded, independent of CD30 expression. In patients with MF/Sézary syndrome, the overall response rate was 50% (five of 10 patients) in patients with low CD30 expression (< 10%), 58% (seven of 12 patients) in patients with medium expression (10% to 50%), and 50% (three of six patients) in patients with high expression (≥ 50%). Time to response was 12 weeks (range, 3 to 39 weeks), and duration of response was 32 weeks (range, 3 to 93 weeks). All patients with lymphomatoid papulosis (n = 9) and primary cutaneous anaplastic T-cell lymphomas (n = 2) responded; time to response was 3 weeks (range, 3 to 9 weeks), and median duration of response was 26 weeks (range, 6 to 44 weeks). Soluble baseline CD30 levels were lowest in complete responders (P = .036). Grade 1 to 2 peripheral neuropathy was observed in 65% of patients (95% CI, 52% to 79%; 31 of 48 patients), is still ongoing in 55% of patients (95% CI, 41% to 69%; 17 of 31 patients), and resolved in 45% of patients (95% CI, 31% to 59%; 14 of 31 patients), with a median time to resolution of 41.5 weeks. Grade 3 to 4 events were neutropenia (n = 5), nausea (n = 2), chest pain (n = 2), deep vein thrombosis (n = 1), transaminitis (n = 1), and dehydration (n = 1). Dose reductions to 1.2 mg/kg were instituted as a result of grade 2 neuropathy (n = 6), transaminitis (n = 1

Results of a Phase II Trial of Brentuximab Vedotin for CD30+ Cutaneous T-Cell Lymphoma and Lymphomatoid Papulosis

PubMed Central

Duvic, Madeleine; Tetzlaff, Michael T.; Gangar, Pamela; Clos, Audra L.; Sui, Dawen; Talpur, Rakhshandra

2015-01-01

Purpose Brentuximab vedotin, a monoclonal antibody (cAC10) conjugated to monomethyl auristatin E, targets CD30+ receptors. This phase II open-label trial was conducted to evaluate safety and efficacy in CD30+ cutaneous T-cell lymphomas. Patients and Methods Forty-eight patients with CD30+ lymphoproliferative disorders or mycosis fungoides (MF) received an infusion of 1.8 mg/kg every 21 days. Results Forty-eight evaluable patients (22 women and 26 men; median age, 59.5 years) had an overall response rate of 73% (95% CI, 60% to 86%; 35 of 48 patients) and complete response rate of 35% (95% CI, 22% to 49%; 17 of 48 patients). Fifteen (54%; 95% CI, 31% to 59%) of 28 patients with MF responded, independent of CD30 expression. In patients with MF/Sézary syndrome, the overall response rate was 50% (five of 10 patients) in patients with low CD30 expression (< 10%), 58% (seven of 12 patients) in patients with medium expression (10% to 50%), and 50% (three of six patients) in patients with high expression (≥ 50%). Time to response was 12 weeks (range, 3 to 39 weeks), and duration of response was 32 weeks (range, 3 to 93 weeks). All patients with lymphomatoid papulosis (n = 9) and primary cutaneous anaplastic T-cell lymphomas (n = 2) responded; time to response was 3 weeks (range, 3 to 9 weeks), and median duration of response was 26 weeks (range, 6 to 44 weeks). Soluble baseline CD30 levels were lowest in complete responders (P = .036). Grade 1 to 2 peripheral neuropathy was observed in 65% of patients (95% CI, 52% to 79%; 31 of 48 patients), is still ongoing in 55% of patients (95% CI, 41% to 69%; 17 of 31 patients), and resolved in 45% of patients (95% CI, 31% to 59%; 14 of 31 patients), with a median time to resolution of 41.5 weeks. Grade 3 to 4 events were neutropenia (n = 5), nausea (n = 2), chest pain (n = 2), deep vein thrombosis (n = 1), transaminitis (n = 1), and dehydration (n = 1). Dose reductions to 1.2 mg/kg were instituted as a result of grade 2 neuropathy

Monitoring of the Polar Stratospheric Clouds formation and evolution in Antarctica in August 2007 during IPY with the MATCH method applied to lidar data

NASA Astrophysics Data System (ADS)

Montoux, Nadege; David, Christine; Klekociuk, Andrew; Pitts, Michael; di Liberto, Luca; Snels, Marcel; Jumelet, Julien; Bekki, Slimane; Larsen, Niels

2010-05-01

The project ORACLE-O3 ("Ozone layer and UV RAdiation in a changing CLimate Evaluated during IPY") is one of the coordinated international proposals selected for the International Polar Year (IPY). As part of this global project, LOLITA-PSC ("Lagrangian Observations with Lidar Investigations and Trajectories in Antarctica and Arctic, of PSC") is devoted to Polar Stratospheric Clouds (PSC) studies. Indeed, understanding the formation and evolution of PSC is an important issue to quantify the impact of climate changes on their frequency of formation and, further, on chlorine activation and subsequent ozone depletion. In this framework, three lidar stations performed PSC observations in Antarctica during the 2006, 2007, and 2008 winters: Davis (68.58°S, 77.97°E), McMurdo (77.86°S, 166.48°E) and Dumont D'Urville (66.67°S, 140.01°E). The data are completed with the lidar data from CALIOP ("Cloud-Aerosol Lidar with Orthogonal Polarization") onboard the CALIPSO ("Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation") satellite. Lagrangian trajectory calculations are used to identify air masses with PSCs sounded by several ground-based lidar stations with the same method, called MATCH, applied for the first time in Arctic to study the ozone depletion with radiosoundings. The evolution of the optical properties of the PSCs and thus the type of PSCs formed (supercooled ternary solution, nitric acid trihydrate particles or ice particles) could thus be linked to the thermodynamical evolution of the air mass deduced from the trajectories. A modeling with the microphysical model of the Danish Meteorological Institute allows assessing our ability to predict PSCs for various environmental conditions. Indeed, from pressure and temperature evolution, the model allows retrieving the types of particles formed as well as their mean radii, their concentrations and could also simulate the lidar signals. In a first step, a case in August 2007 around 17-18 km, involving

HP2 survey. III. The California Molecular Cloud: A sleeping giant revisited

NASA Astrophysics Data System (ADS)

Lada, Charles J.; Lewis, John A.; Lombardi, Marco; Alves, João

2017-10-01

suggesting that cloud structure plays a major role in setting the global star formation rates in GMCs HP2 (Herschel-Planck-2MASS) survey is a continuation of the series originally entitled "Herschel-Planck dust opacity and column density maps" (Lombardi et al. 2014, Zari et al. 2016).The reduced Herschel and Planck map and the column density and temperature maps are available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/606/A100

Vlasov simulations of electron hole dynamics in inhomogeneous magnetic field

NASA Astrophysics Data System (ADS)

Kuzichev, Ilya; Vasko, Ivan; Agapitov, Oleksiy; Mozer, Forrest; Artemyev, Anton

2017-04-01

particular, our simulations suggest that slow EHs (which generation is usually attributed to the Buneman instability) can arise due to slowing down of fast EH generated by electron-beam instability. The estimate of the potential drop along EHs allow to estimate the parallel potential drop provided by EHs in a particular plasma system. 1. Matsumoto, H., H. Kojima, T. Miyatake, Y. Omura, M. Okada, I. Nagano, and M. Tsutsui, Electrotastic Solitary Waves (ESW) in the magnetotail: BEN wave forms observed by GEOTAIL, Geophys. Res. Lett., 21, 2915-2918, doi:10.1029/94GL01284, 1994. 2. Norgren, C., M. Andŕe, A. Vaivads, and Y. V. Khotyaintsev, Slow electron phase space holes: Magnetotail observations, Geophys. Res. Lett., 42, 1654-1661, doi:10.1002/2015GL063218, 2015. 3. Malaspina, D. M., J. R. Wygant, R. E. Ergun, G. D. Reeves, R. M. Skoug, and B. A. Larsen, Electric field structures and waves at plasma boundaries in the inner magnetosphere, Journal of Geophysical Research (Space Physics), 120, 4246-4263, doi:10.1002/2015JA021137, 2015. 4. Franz, J. R., P. M. Kintner, J. S. Pickett, and L.-J. Chen, Properties of small-amplitude electron phase-space holes observed by Polar, Journal of Geophysical Research (Space Physics), 110, A09212, doi:10.1029/2005JA011095, 2005. 5. Cattell, C., C. Neiman, J. Dombeck, J. Crumley, J. Wygant, C. A. Kletzing, W. K. Peterson, F. S. Mozer, and M. André (2003), Large amplitude solitary waves in and near the Earth's magnetosphere, magnetopause and bow shock: Polar and Cluster observations, Nonlinear Processes Geophys., 10, 13-26. 6. Mandrake, L., P. L. Pritchett, and F. V. Coroniti, Electron beam generated solitary structures in a nonuniform plasma system, Geophys. Res. Lett., 27, 2869-2872, doi:10.1029/2000GL003785, 2000. The work of I.K. was supported by Russian Foundation for Basic Research 16-32-00721 mol_a. The work of I.V., O.A. and F.M. was supported by JHU/APL contract 922613 (RBSPEFW).

Evaluation and Management of the Gas and Rock Outburst Hazard in the Light of International Legal Regulations

NASA Astrophysics Data System (ADS)

Skoczylas, Norbert; Wierzbicki, Mirosław

2014-12-01

ądzanie ryzykiem wyrzutu, ale dają natomiast zarys tego, jakie elementy muszą być uwzględnione w rozwoju zarządzaniu ryzykiem. Kategoryzacja zagrożenia wyrzutowego w krajach europejskich i w Chinach ma wiele cech wspólnych. Ustalane są najczęściej dwie, lub trzy kategorie zagrożenia. Często incydenty wyrzutów, bądź poważnych symptomów mogących świadczyć o zagrożeniu są podstawą do zaliczenia pokładu do najwyższej kategorii zagrożenia. Dominującym parametrem w podstawowej ocenie zagrożenia wyrzutowego jest zawartość metanu w pokładzie węgla. Występuje ona w aktach prawnych wszystkich krajów, które narzucają konkretne sposoby określana stanu zagrożenia, jedynie przepisy chińskie nie obligują do badań zawartości gazu w węglu. W przepisach chińskich pojawia się pomiar ciśnienia gazu.

Human retroviruses in leukaemia and AIDS: reflections on their discovery, biology and epidemiology.

PubMed

Karpas, Abraham

2004-11-01

The study of retroviruses has had a profound impact by unveiling an unusual form of viral replication: the multiplication of RNA viruses via a proviral DNA, for which Jan Svoboda provided the experimental model over forty years ago. In 1970 Temin, Mizutani and Baltimore discovered that this group of viruses contains a unique enzyme catalysing the synthesis of a DNA copy of the viral RNA: reverse transcriptase (RT). The discovery of RT has itself had an enormous impact on molecular biology in general, but also stimulated many premature claims of its detection in human disease. Claims by Gallo's laboratory that the cytoplasm of human leukaemia cells contained RT proved to be unfounded, as did his report in collaboration with Weiss that myeloid leukaemia contained HL23 virus, this organism proving not to be human but a laboratory contaminant of three monkey viruses. Conclusive demonstration of a retroviral involvement in human leukaemia was first provided in 1981 by Hinuma and his associates, showing that adult T-cell leukaemia (ATL), a rare form of leukaemia endemic to south-west Japan, is caused by a new retrovirus (ATLV). Other publications in December 1980 and through 1981 claimed the discovery of a new human T-cell leukaemia virus involved in mycosis fungoides (MF) and Sézary's syndrome (SS). This virus was termed HTLV by Gallo. The nucleotide sequence of ATLV is strongly conserved, that of my 1983 isolate from a black British ATL patient being practically identical with the Japanese virus isolates. After AIDS was recognised in 1981 by Gottlieb and coworkers as a new human disease, several papers were published by Gallo and his associates during 1983-4, invoking the oncovirus responsible for adult T-cell leukaemia as the cause of AIDS. In 1983 the French scientist Barré-Sinoussi and her colleagues succeeded in isolating a new agent in the disease, a lentivirus, which they named LAV. The French immunologist Klatzmann and his colleagues discovered that LAV killed