Sample records for zdenek pliva ondrej

  1. Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and distended stomach, and vascular response.


    Sikiric, P; Seiwerth, S; Brcic, L; Blagaic, A B; Zoricic, I; Sever, M; Klicek, R; Radic, B; Keller, N; Sipos, K; Jakir, A; Udovicic, M; Tonkic, A; Kokic, N; Turkovic, B; Mise, S; Anic, T


    Gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419, safe in clinical trials for inflammatory bowel disease (PL 10, PLD 116, PLD 14736, Pliva, Croatia)) has a particular cytoprotective/adaptive cytoprotective activity. The cytoprotective/adaptive cytoprotection researches largely neglect that stomach distension could per se jeopardize the mucosal integrity, with constantly stretched mucosa and blood vessels, and sphincters more prone for reflux induction. After absolute alcohol instillation in fully distended rat stomach, gastric, esophageal and duodenal lesions occur. Throughout next 3 min, left gastric artery blood vessels clearly disappear at the serosal site, indicative for loss of vessels both integrity and function. Contrary, constant vessels presentation could predict the beneficial effect of applied agent. After pentadecapeptide BPC 157 instillation into the stomach the vessels presentation remains constant, and lesions of stomach, esophagus, and duodenum are inhibited. Standards (atropine, ranitidine, omeprazole) could only slightly improve the vessels presentation compared to control values, and they have only a partial effect on the lesions. In this review we emphasize BPC 157 unusual stability, and some of its important effects: effectiveness against various lesions in gastrointestinal tract, on nitric oxide (NO)-system, and NO-agents effects, on somatosensory neurons, salivary glands function, recovery of AMP-ADP-ATP system, endothelium protection, effect on endothelin, and on angiogenesis promotion. It also antagonizes other alcohol effects, including acute and chronic intoxication. Given peripherally, it counteracts the consequence of central dopamine system disturbances (receptor blockade), and induces serotonin release in substantia nigra. Therapeutic potential of BPC 157 as a cytoprotective agent is also seen in its capability to heal various wounds. Given directly into the stomach, BPC 157 instantly recovers disturbed lower esophageal

  2. Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL14736, Pliva, Croatia) heals ileoileal anastomosis in the rat.


    Vuksic, Tihomir; Zoricic, Ivan; Brcic, Luka; Sever, Marko; Klicek, Robert; Radic, Bozo; Cesarec, Vedran; Berkopic, Lidija; Keller, Neike; Blagaic, Alenka Boban; Kokic, Neven; Jelic, Ivan; Geber, Juraj; Anic, Tomislav; Seiwerth, Sven; Sikiric, Predrag


    Gastric pentadecapeptide BPC 157 (BPC 157), which has been shown to be safe in clinical trials for inflammatory bowel disease (PL-10, PLD-116, PL14736, Pliva, Croatia), may be able to cure intestinal anastomosis dehiscence. This antiulcer peptide shows no toxicity, is limit test negative, and a lethal dose is not achieved. It is stable in human gastric juice. In comparison with other standard treatments it is more effective for ulcers and various wounds, and can be used without a carrier needed for other peptides, both locally and systemically (i.e., perorally, parenterally). We studied the effectiveness of BPC 157 for ileoileal anastomosis healing in rats. We assessed ileoileal anastomosis dehiscence macroscopically, histologically, and biomechanically (volume [ml] infused through a syringe-perfusion pump system (1 ml/10 s), and pressure [mmHg] to leak induction [catheter connected to a chamber and a monitor, at 10 cm proximal to anastomosis]), at 1, 2, 3, 4, 5, 6, 7, and 14 days. BPC 157 (10 microg, 10 ng, 10 pg/kg i.p. (or saline [5 ml/kg]) was first administered after surgery, while it was last given 24 h before either assessment or sacrifice. Throughout the experiment, both higher doses of BPC 157 were shown to improve all parameters of anastomotic wound healing. The formation of adhesions remained slight, the blood vessels were filled with blood, and a mild intestinal passage obstruction was only temporarily observed. Anastomosis without leakage induces markedly higher volume and pressure values, with a continuous increase toward healthy values. From day 1, edema was markedly attenuated and the number of granulocytes decreased, while from days 4 or 5 necrosis decreased and granulation tissue, reticulin, and collagen formation substantially increased, thus resulting in increased epithelization. This study showed BPC 157 to have a beneficial effect on ileoileal anastomosis healing in the rat.

  3. SymPy: Symbolic computing in python


    Meurer, Aaron; Smith, Christopher P.; Paprocki, Mateusz; ...


    Here, SymPy is a full featured computer algebra system (CAS) written in the Python programming language. It is open source, being licensed under the extremely permissive 3-clause BSD license. SymPy was started by Ondrej Certik in 2005, and it has since grown into a large open source project, with over 500 contributors.

  4. SciTech Connect

    Meurer, Aaron; Smith, Christopher P.; Paprocki, Mateusz

    Here, SymPy is a full featured computer algebra system (CAS) written in the Python programming language. It is open source, being licensed under the extremely permissive 3-clause BSD license. SymPy was started by Ondrej Certik in 2005, and it has since grown into a large open source project, with over 500 contributors.

  5. Co-training Framework of Generative and Disciminative Trackers with Partial Occlusion Handling

    DTIC Science & Technology


    ARO W911NF-06-1-0094. The first author was also supported by the Vietnam Education Foundation. We thank Zdenek Kalal for his help with the P-N Tracker...handling challenging situations with cluttered background. Recently, Kalal et al. [11] proposed the P-N Tracker us- ing positive and negative constraints to...Vietnam Education Foundation. We thank Zdenek Kalal for his help with the P-N Tracker [11]. References [1] A. Adam, E. Rivlin, and I. Shimshoni. Robust

  6. Cost Efficiency Implications of International Cooperation (Implications de rentabilite de la cooperation internationale)

    DTIC Science & Technology


    CZECH REPUBLIC Col. Zdenek Petras Centre for Security and Military Strategic Studies University of Defence Kounicova 156/65 66210 Brno Email...military systems in order to reduce costs. Nine Nations are cooperating with Lockheed Martin to develop and produce the next generation fighter led by the technologically first-tier Nation, the US, where Lockheed Martin is the managing authority on the supply side and the US F-35 Joint

  7. Clinical evaluation of Altra-Flux 140 cellulose diacetate hollow-fiber dialyzer.


    Kes, P; Ratković-Gusić, I; Prsa, M


    Clinical evaluation of Altra-Flux 140, a new Pliva hollow-fiber type dialyzer showed the clearances and removal rate of small molecular weight solutes to be satisfactory during 4-hour dialysis. The ultrafiltration rate was high, but acceptable when used with volumetric-controlled hemodialysis delivery systems. Biocompatibility was good, and there were no intradialytic symptoms in patients, attributable to the use of Altra-Flux 140. In general, no residual blood was detected. Handling of Altra-Flux 140 was found to be easy and the membrane strength adequate.

  8. A short story of imaging and spectroscopy of two-dimensional materials by scanning transmission electron microscopy

    SciTech Connect

    Idrobo Tapia, Juan Carlos; Zhou, Wu

    Here we present a short historical account of when single adatom impurities where first identified in two-dimensional materials by scanning transmission electron microscopy (STEM). We also present a study of the graphene low-loss (below 50 eV) response as a function of number of layers using electron energy-loss spectroscopy (EELS). The study shows that as few as three layers of graphene behave as bulk graphite for losses above 10 eV We also show examples of how point and extended defects can easily be resolved and structural dynamics can be readily capture by using aberration-corrected STEM imaging. Lastly, we show that themore » new generation of monochromators has opened up possibilities to explore new physics with an electron microscope. All these capabilities were enabled by the development of spherical aberration correctors and monochromators, where Ondrej Krivanek has played a key role.« less

  9. A short story of imaging and spectroscopy of two-dimensional materials by scanning transmission electron microscopy.


    Idrobo, Juan C; Zhou, Wu


    Here we present a short historical account of when single adatom impurities where first identified in two-dimensional materials by scanning transmission electron microscopy (STEM). We also present a study of the graphene low-loss (below 50eV) response as a function of number of layers using electron energy-loss spectroscopy (EELS). The study shows that as few as three layers of graphene behave as bulk graphite for losses above 10eV We also show examples of how point and extended defects can easily be resolved and structural dynamics can be readily capture by using aberration-corrected STEM imaging. Finally, we show that the new generation of monochromators has opened up possibilities to explore new physics with an electron microscope. All these capabilities were enabled by the development of spherical aberration correctors and monochromators, where Ondrej Krivanek has played a key role. Copyright © 2017. Published by Elsevier B.V.

  10. A short story of imaging and spectroscopy of two-dimensional materials by scanning transmission electron microscopy


    Idrobo Tapia, Juan Carlos; Zhou, Wu


    Here we present a short historical account of when single adatom impurities where first identified in two-dimensional materials by scanning transmission electron microscopy (STEM). We also present a study of the graphene low-loss (below 50 eV) response as a function of number of layers using electron energy-loss spectroscopy (EELS). The study shows that as few as three layers of graphene behave as bulk graphite for losses above 10 eV We also show examples of how point and extended defects can easily be resolved and structural dynamics can be readily capture by using aberration-corrected STEM imaging. Lastly, we show that themore » new generation of monochromators has opened up possibilities to explore new physics with an electron microscope. All these capabilities were enabled by the development of spherical aberration correctors and monochromators, where Ondrej Krivanek has played a key role.« less

  11. The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice.


    Blagaic, Alenka Boban; Blagaic, Vladimir; Romic, Zeljko; Sikiric, Predrag


    The stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W.1419), which was promising in inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) trials, protects against both acute and chronic alcohol-induced lesions in stomach and liver, but also, given peripherally, affects various centrally mediated disturbances. Now, in male NMRI mice BPC 157 (10 pg intraperitoneally, 10 ng and 10 microg, intraperitoneally or intragastrically) (i) strongly opposed acute alcohol (4 g/kg intraperitoneally) intoxication (i.e., quickly produced and sustained anesthesia, hypothermia, increased ethanol blood values, 25% fatality, 90-min assessment period) given before or after ethanol, and (ii) when given after abrupt cessation of ethanol (at 0 or 3 or 7 h withdrawal time), attenuated withdrawal (assessed through 24 hours) after 20%-alcohol drinking (7.6 g/kg) through 13 days, with provocation on the 14th day.

  12. Increase in specific density of levobupivacaine and fentanyl solution ensures lower incidence of inadequate block.


    Djeno, Ivana Tudorić; Duzel, Viktor; Ajduk, Marko; Oremus, Zrinka Safarić; Zupcić, Miroslav; Dusper, Silva; Jukić, Dubravko; Husedzinović, Ino


    The clinical presentation of a subarachnoid block (SAB) is dependent upon the intrathecal spread of local anesthetic (LA). Intrathecal distribution depends on the chemical and physical characteristics of LA, puncture site, technique used, patient anatomical characteristics and hydrodynamic properties of cerebrospinal fluid. We tried to determine whether a combined glucose/LA solution can render a clinically significant difference in sensory block distribution and motor block intensity.This was a controlled, randomized and double blinded study. The surgical procedures were stripping of the great or small saphenous vein and extirpation of remaining varicose veins. The study included 110 patients distributed into two groups: Hyperbaric (7.5 mg levobupivacaine (1.5 ml 0.5% Chirocaine) + 50 microg Fentanyl (0.5 ml Fentanil) and 1 ml 10% glucose (Pliva)) vs. Hypobaric (7.5 mg levobupivacaine (1.5 ml 0.5% Chirocaine) + 50 microg Fentanyl (0.5 ml Fentanil) and 1 ml 0.9% NaCl (Pliva, Zagreb)) adding to a total volume of 3.5 ml per solution. Spinal puncture was at L3-L4 level. Spinal block distribution was assessed in five minute intervals and intensity of motor block was assessed according to the modified Bromage scale. Pain was assessed with the Visual Analogue Scale. A statistically significant difference in sensory block distribution, motor block intensity and recovery time was established between hyperbaric and hypobaric solutions. By increasing the specific density of anesthetic solution, a higher sensory block, with lesser variability, a diminished influence of Body Mass Index, decreased motor block intensity and faster recovery time may be achieved.

  13. Eye drops preservative as the cause of corneal band keratopathy in long-term pilocarpine hydrochloride treatment.


    Pavicić-Astalos, Jasna; Lacmanović-Loncar, Valentina; Petric-Vicković, Ivanka; Sarić, Dean; Mandić, Zdravko; Csik, Tigrena; Susić, Nikola


    The aim is to present a patient with severe bilateral corneal complications after long-term antiglaucoma treatment with 1% pilocarpine hydrochloride (Pilokarpin, Pliva, Zagreb, Croatia) and its management. A patient with narrow-angle glaucoma treated with 1% topical pilocarpine hydrochloride eye drops for the last twenty years complained of impaired vision, intermittent visual haloes and eye redness. Ophthalmologic examination showed bilateral band keratopathy, peripheral laser iridotomy, medicamentous myosis, brown nuclear cataract, and synchysis scintillans of his right eye. Band keratopathy was thought to have resulted from the presence of the preservative phenylmercuric nitrate in the pilocarpine hydrochloride eye drops. Treatment of the patient consisted of two separate procedures for both eyes, i.e. phaco trabeculectomy and six months later corneal procedure including abrasion of corneal epithelium followed by removal of the superficial stromal calcium deposits by means of a 3.75% ethylenediaminetetraacetic (EDTA) solution. After phaco trabeculectomy, visual acuity was 0.8 on both eyes. Bilateral visual improvement with visual acuity 1.0 was recorded after corneal treatment with EDTA. In conclusion, one must be aware of preservative complications in long-term topical use, such as band keratopathy that can be visually incapacitating. Surgical treatment using EDTA is safe and effective treatment for band keratopathy.

  14. Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157.


    Staresinic, Mario; Petrovic, Igor; Novinscak, Tomislav; Jukic, Ivana; Pevec, Damira; Suknaic, Slaven; Kokic, Neven; Batelja, Lovorka; Brcic, Luka; Boban-Blagaic, Alenka; Zoric, Zdenka; Ivanovic, Domagoj; Ajduk, Marko; Sebecic, Bozidar; Patrlj, Leonardo; Sosa, Tomislav; Buljat, Gojko; Anic, Tomislav; Seiwerth, Sven; Sikiric, Predrag


    We report complete transection of major muscle and the systemic peptide treatment that induces healing of quadriceps muscle promptly and then maintains the healing with functional restoration. Initially, stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419, PL-10, PLD-116, PL 14736 Pliva, Croatia; in trials for inflammatory bowel disease; wound treatment; no toxicity reported; effective alone without carrier) also superiorly accelerates the healing of transected Achilles tendon. Regularly, quadriceps muscle completely transected transversely 1.0 cm proximal to patella presents a definitive defect that cannot be compensated in rat. BPC 157 (10 microg, 10 ng, 10 pg/kg) is given intraperitoneally, once daily; the first application 30 min posttransection, the final 24 h before sacrifice. It consistently improves muscle healing throughout the whole 72-day period. Improved are: (i) biomechanic (load of failure increased); (ii) function (walking recovery and extensor postural thrust/motor function index returned toward normal healthy values); (iii) microscopy/immunochemistry [i.e., mostly muscle fibers connect muscle segments; absent gap; significant desmin positivity for ongoing regeneration of muscle; larger myofibril diameters on both sides, distal and proximal (normal healthy rat-values reached)]; (iv) macroscopic presentation (stumps connected; subsequently, atrophy markedly attenuated; finally, presentation close to normal noninjured muscle, no postsurgery leg contracture). Thus, posttransection healing-consistently improved-may suggest this peptide therapeutic application in muscle disorders. Copyright 2006 Orthopaedic Research Society.

  15. Gastric pentadecapeptide BPC 157 counteracts morphine-induced analgesia in mice.


    Boban Blagaic, A; Turcic, P; Blagaic, V; Dubovecak, M; Jelovac, N; Zemba, M; Radic, B; Becejac, T; Stancic Rokotov, D; Sikiric, P


    Previously, the gastric pentadecapeptide BPC 157, (PL 14736, Pliva) has been shown to have several beneficial effects, it exert gastroprotective, anti-inflammatory actions, stimulates would healing and has therapeutic value in inflammatory bowel disease. The present study aimed to study the effect of naloxone and BPC 157 on morphine-induced antinociceptive action in hot plate test in the mouse. It was found that naloxone and BPC 157 counteracted the morphine (16 mg/kg s.c.) - analgesia. Naloxone (10 mg/kg s.c.) immediately antagonised the analgesic action and the reaction time returned to the basic values, the development of BPC 157-induced action (10 pg/kg, 10 ng/kg, 10 microg/kg i.p.) required 30 minutes. When haloperidol, a central dopamine-antagonist (1 mg/kg i.p.), enhanced morphine-analgesia, BPC 157 counteracted this enhancement and naloxone reestablished the basic values of pain reaction. BPC 157, naloxone, and haloperidol per se failed to exert analgesic action. In summary, interaction between dopamine-opioid systems was demonstrated in analgesia, BPC 157 counteracted the haloperidol-induced enhancement of the antinociceptive action of morphine, indicating that BPC acts mainly through the central dopaminergic system.

  16. Gastric pentadecapeptide BPC 157 and short bowel syndrome in rats.


    Sever, Marko; Klicek, Robert; Radic, Bozo; Brcic, Luka; Zoricic, Ivan; Drmic, Domagoj; Ivica, Mihovil; Barisic, Ivan; Ilic, Spomenko; Berkopic, Lidija; Blagaic, Alenka Boban; Coric, Marijana; Kolenc, Danijela; Vrcic, Hrvoje; Anic, Tomislav; Seiwerth, Sven; Sikiric, Predrag


    The gastric pentadecapeptide BPC 157, which was shown to be safe as an antiulcer peptide in trials for inflammatory bowel disease (PL14736, Pliva), successfully healed intestinal anastomosis and fistula in rat. Therefore, we studied for 4 weeks rats with escalating short bowel syndrome and progressive weight loss after small bowel resection from fourth ileal artery cranially of ileocecal valve to 5 cm beneath pylorus. BPC 157 (10 microg/kg or 10 ng/kg) was given perorally, in drinking water (12 ml/rat/day) or intraperitoneally (once daily, first application 30 min following surgery, last 24 h before sacrifice). Postoperatively, features of increasingly exhausted presentation were: weight loss appearing immediately regardless of villus height, twofold increase in crypt depth and fourfold increase in muscle thickness within the first week, jejunal and ileal overdilation, and disturbed jejunum/ileum relation. In contrast, constant weight gain above preoperative values was observed immediately with BPC 157 therapy, both perorally and parenterally, and villus height, crypt depth, and muscle thickness [inner (circular) muscular layer] also increased, at 7, 14, 21, and 28 days. Moreover, rats treated with pentadecapeptide BPC 157 showed not different jejunal and ileal diameters, constant jejunum-to-ileum ratio, and increased anastomosis breaking strength. In conclusion, pentadecapeptide BPC 157 could be helpful to cure short bowel syndrome.

  17. Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: Promoted tendon-to-bone healing and opposed corticosteroid aggravation.


    Krivic, Andrija; Anic, Tomislav; Seiwerth, Sven; Huljev, Dubravko; Sikiric, Predrag


    Stable gastric pentadecapeptide BPC 157 (BPC 157, as an antiulcer agent in clinical trials for inflammatory bowel disease; PLD-116, PL 14736, Pliva, no toxicity reported) alone (without carrier) ameliorates healing of tendon and bone, respectively, as well as other tissues. Thereby, we focus on Achilles tendon-to-bone healing: tendon to bone could not be healed spontaneously, but it was recovered by this peptide. After the rat's Achilles tendon was sharply transected from calcaneal bone, agents [BPC 157 (10 microg, 10 ng, 10 pg), 6alpha-methylprednisolone (1 mg), 0.9% NaCl (5 mL)] were given alone or in combination [/kg body weight (b.w.) intraperitoneally, once time daily, first 30-min after surgery, last 24 h before analysis]. Tested at days 1, 4, 7, 10, 14, and 21 after Achilles detachment, BPC 157 improves healing functionally [Achilles functional index (AFI) values substantially increased], biomechanically (load to failure, stiffness, and Young elasticity modulus significantly increased), macro/microscopically, immunohistochemistry (better organization of collagen fibers, and advanced vascular appearance, more collagen type I). 6alpha-Methylprednisolone consistently aggravates the healing, while BPC 157 substantially reduces 6alpha-methylprednisolone healing aggravation. Thus, direct tendon-to-bone healing using stabile nontoxic peptide BPC 157 without a carrier might successfully exchange the present reconstructive surgical methods. Copyright 2006 Orthopaedic Research Society.

  18. The Collision of Comet Shoemaker-Levy 9 and Jupiter

    NASA Astrophysics Data System (ADS)

    Noll, Keith S.; Weaver, Harold A.; Feldman, Paul D.


    Participants; Preface; 1. The orbital motion and impact circumstances of Comet Shoemaker-Levy 9 Paul W. Chodas and Donald K. Yeomans; 2. Observational constraints on the composition and nature of Comet D/Shoemaker-Levy 9 Jacques Crovisier; 3. Tidal breakup of the nucleus of Comet Shoemaker-Levy 9 Zdenek Sekanina; 4. Earth-based observations of impact phenomena Philip D. Nicholson; 5. HST imaging of Jupiter shortly after each impact: plumes and fresh sites Heidi B. Hammel; 6. Galileo observations of the impacts Clark R. Chapman; 7. Models of fragment penetration and fireball evolution David A. Crawford; 8. Entry and fireball models vs. observations: what have we learned? Mordecai-Mark Mac Low; 9. Dynamics and chemistry of SL9 plumes Kevin Zahnle; 10. Chemistry induced by the impacts: observations Emmanuel Lellouch; 11. SL9 impact chemistry: long-term photochemical evolution Julianne I. Moses; 12. Particulate matter in Jupiter's atmosphere from the impacts of Comet P/Shoemaker-Levy 9 Robert A. West; 13. Jupiter's post-impact atmospheric thermal response Barney J. Conrath; 14. Growth and dispersion of the Shoemaker-Levy 9 impact features from HST imaging Reta F. Beebe; 15. Waves from the Shoemaker-Levy 9 impacts Andrew P. Ingersoll and Hiroo Kanamori; 16. Jovian magnetospheric and auroral effects of the SL9 impacts Wing-Huen Ip.

  19. [Etiology and pathogenesis of inflammatory bowel diseases].


    Lukáš, Milan


    Zdenek Mařatka has been the first physician, who had brought a new information for the Czech medical community with topic of inflammatory bowel diseases, which had been systematic studied for him. He had prepared an original theory - two component hypothesis about origin of ulcerative colitis, which had been developed and innovated by him for long time. From the international point of view, Mařatka has had an extraordinary impact and significant contribution for recognition of ulcerative colitis and Crohn´s disease. Despite the fact that the true origin of ulcerative colitis and Crohn´s disease (UC) still remain elusive, basic as well as clinical research bring many new data on etiology and pathogenesis of this inflammatory condition. It seems clear that IBD originate from interaction of several intrinsic and extrinsic factors that contribute individually in a particular patient. Among internal factors the genes play an important role, because its influence on the mucosal immunity system and immunological response. Among the external factors importance are recognized the gut microbiota content, cigarette smoking and psychological stress.

  20. Commemorating John Dyson

    NASA Astrophysics Data System (ADS)

    Pittard, Julian M.


    John Dyson was born on the 7th January 1941 in Meltham Mills, West Yorkshire, England, and later grew up in Harrogate and Leeds. The proudest moment of John's early life was meeting Freddie Trueman, who became one of the greatest fast bowlers of English cricket. John used a state scholarship to study at Kings College London, after hearing a radio lecture by D. M. McKay. He received a first class BSc Special Honours Degree in Physics in 1962, and began a Ph.D. at the University of Manchester Department of Astronomy after being attracted to astronomy by an article of Zdenek Kopal in the semi-popular journal New Scientist. John soon started work with Franz Kahn, and studied the possibility that the broad emission lines seen from the Orion Nebula were due to flows driven by the photoevaporation of neutral globules embedded in a HII region. John's thesis was entitled ``The Age and Dynamics of the Orion Nebula`` and he passed his oral examination on 28th February 1966.

  1. Low energy electron-molecule scattering using the R-matrix method

    NASA Astrophysics Data System (ADS)

    Gorfinkiel, Jimena


    The study of electron-molecule collisions continues to attract significant interest stimulated, in no small part, by the need for collisional data to model a number of physical environments and applied processes (e.g. the modelling of focused electron beam induced deposition and the description of the interaction of radiation with biological matter). This need for electron scattering data (cross sections but also information on the temporary negative ions, TNI, that can be formed) has motivated the renewed development of theoretical methodology and their computational implementation. I will present the latest developments in the study of low energy electron scattering from molecules and molecular clusters using the R-matrix method. Recent calculations on electron collisions with biologically relevant molecules have shed light on the formation of core-excited TNI these larger targets. The picture that emerges is much more complex than previously thought. I will discuss some examples as well as current and future developments of the methodology and software in order to provide more accurate collisional data (in particular cross sections) for bigger targets. In collaboration with Zdenek Masin, The Open University. This work was partially supported by EPSRC.

  2. Professor Eugen Cerkovnikov (1904-1985): the founder of the Chemical and Biochemical Institute of the Rijeka University School of Medicine.


    Milin, Cedomila


    Professor Eugen Cerkovnikov, PhD (Kamenska, Russia, 1904- Rijeka, Croatia 1985) graduated in chemical technology from the Faculty of Engineering in Zagreb in 1929. His first job was at the School of Medicine in Paris in 1930, and then he moved to Zagreb to the Department of Organic Chemistry of the Faculty of Engineering run by our Nobel Prize winner Vladimir Prelog (1935-1938). There he took his PhD degree with a dissertation on piperidine gamma derivatives. From 1938 to 1947 he was a research associate at an institute established by the pharmaceutical company Kastel (later Pliva). This is when he became a lecturer at the Faculty of Pharmacy in Zagreb and the first director of the Institute of Organic Chemistry, established in 1946/47. In 1948 he became reader, and in 1956 (full) professor. In 1957 he moved to the newly established School of Medicine in Rijeka, and set up the Institute of Chemistry and Biochemistry. He ran the Institute until retirement in 1975. He was the second dean of the Rijeka University School of Medicine and a pioneer of quantum chemistry and medical cybernetics in undergraduate and (post)graduate courses. His scientific work consists of over 200 papers published at home and abroad, 60 professional papers, 20 book reviews, three works of translation, and 27 volumes of lecture notes. In 1958, professor Cerkovnikov established the Croatian Chemical Society and the Rijeka and Istria branches of the nation's Association of Chemists and Chemical Engineers, chairing them until 1974. In addition, he was one of the founding fathers, and the first chair of the Health Culture Studies Association in Rijeka (that preceded today's Croatian Scientific Society for the History of Health Culture), established in 1965.

  3. Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth.


    Staresinic, M; Sebecic, B; Patrlj, L; Jadrijevic, S; Suknaic, S; Perovic, D; Aralica, G; Zarkovic, N; Borovic, S; Srdjak, M; Hajdarevic, K; Kopljar, M; Batelja, L; Boban-Blagaic, A; Turcic, I; Anic, T; Seiwerth, S; Sikiric, P


    In studies intended to improve healing of transected Achilles tendon, effective was a stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419). Currently in clinical trials for inflammatory bowel disease (PLD-116, PL 14736, Pliva), it ameliorates internal and external wound healing. In rats, the right Achilles tendon transected (5 mm proximal to its calcaneal insertion) presents with a large tendon defect between cut ends. Agents (/kg b.w., i.p., once time daily) (BPC 157 (dissolved in saline, with no carrier addition) (10 microg, 10 ng or 10 pg) or saline (5.0 ml)), were firstly applied at 30 min after surgery, the last application at 24 h before autopsy. Achilles functional index (AFI) was assessed once time daily. Biomechanical, microscopical and macroscopical assessment was on day 1, 4, 7, 10 and 14. Controls generally have severely compromised healing. In comparison, pentadecapeptide BPC 157 fully improves recovery: (i) biomechanically, increased load of failure, load of failure per area and Young's modulus of elasticity; (ii) functionally, significantly higher AFI-values; (iii) microscopically, more mononuclears and less granulocytes, superior formation of fibroblasts, reticulin and collagen; (iv) macroscopically, smaller size and depth of tendon defect, and subsequently the reestablishment of full tendon integrity. Likewise, unlike TGF-beta, pentadecapeptide BPC 157, presenting with no effect on the growth of cultured cell of its own, consistently opposed 4-hydroxynonenal (HNE), a negative modulator of the growth. HNE-effect is opposed in both combinations: BPC 157+HNE (HNE growth inhibiting effect reversed into growth stimulation of cultured tendocytes) and HNE+BPC 157(abolished inhibiting activity of the aldehyde), both in the presence of serum and serum deprived conditions. In conclusion, these findings, particularly, Achilles tendon transection fully recovered in rats, peptide stability suitable delivery, usefully favor gastric

  4. Therapy for unhealed gastrocutaneous fistulas in rats as a model for analogous healing of persistent skin wounds and persistent gastric ulcers: stable gastric pentadecapeptide BPC 157, atropine, ranitidine, and omeprazole.


    Skorjanec, Sandra; Dolovski, Zdravko; Kocman, Ivan; Brcic, Luka; Blagaic Boban, Alenka; Batelja, Lovorka; Coric, Marjana; Sever, Marko; Klicek, Robert; Berkopic, Lidija; Radic, Bozo; Drmic, Domagoj; Kolenc, Danijela; Ilic, Spomenko; Cesarec, Vedran; Tonkic, Ante; Zoricic, Ivan; Mise, Stjepan; Staresinic, Mario; Ivica, Mihovil; Lovric Bencic, Martina; Anic, Tomislav; Seiwerth, Sven; Sikiric, Predrag


    This study focused on unhealed gastrocutaneous fistulas to resolve whether standard drugs that promote healing of gastric ulcers may simultaneously have the same effect on cutaneous wounds, and corticosteroid aggravation, and to demonstrate why peptides such as BPC 157 exhibit a greater healing effect. Therefore, with the fistulas therapy, we challenge the wound/growth factors theory of the analogous nonhealing of wounds and persistent gastric ulcers. The healing rate of gastrocutaneous fistula in rat (2-mm-diameter stomach defect, 3-mm-diameter skin defect) validates macro/microscopically and biomechanically a direct skin wound/stomach ulcer relation, and identifies a potential therapy consisting of: (i) stable gastric pentadecapeptide BPC 157 [in drinking water (10 microg/kg) (12 ml/rat/day) or intraperitoneally (10 microg/kg, 10 ng/kg, 10 pg/kg)], (ii) atropine (10 mg/kg), ranitidine (50 mg/kg), and omeprazole (50 mg/kg), (iii) 6-alpha-methylprednisolone (1 mg/kg) [intraperitoneally, once daily, first application at 30 min following surgery; last 24 h before sacrifice (at postoperative days 1, 2, 3, 7, 14, and 21)]. Greater anti-ulcer potential and efficiency in wound healing compared with standard agents favor BPC 157, efficient in inflammatory bowel disease (PL-14736, Pliva), given in drinking water or intraperitoneally. Even after 6-alpha-methylprednisolone aggravation, BPC 157 promptly improves both skin and stomach mucosa healing, and closure of fistulas, with no leakage after up to 20 ml water intragastrically. Standard anti-ulcer agents, after a delay, improve firstly skin healing and then stomach mucosal healing, but not fistula leaking and bursting strength (except for atropine). We conclude that BPC 157 may resolve analogous nonhealing of wounds and persistent gastric ulcers better than standard agents.

  5. Major results of the MAARBLE project

    NASA Astrophysics Data System (ADS)

    Daglis, Ioannis A.; Bourdarie, Sebastien; Horne, Richard B.; Khotyaintsev, Yuri; Mann, Ian R.; Santolik, Ondrej; Turner, Drew L.; Balasis, Georgios


    The goal of the MAARBLE (Monitoring, Analyzing and Assessing Radiation Belt Loss and Energization) project was to shed light on the ways the dynamic evolution of the Van Allen belts is influenced by low-frequency electromagnetic waves. MAARBLE was implemented by a consortium of seven institutions (five European, one Canadian and one US) with support from the European Community's Seventh Framework Programme. The MAARBLE project employed multi-spacecraft monitoring of the geospace environment, complemented by ground-based monitoring, in order to analyze and assess the physical mechanisms leading to radiation belt particle energisation and loss. Particular attention was paid to the role of ULF/VLF waves. Within MAARBLE we created a database containing properties of ULF and VLF waves, based on measurements from the Cluster, THEMIS and CHAMP missions and from the CARISMA and IMAGE ground magnetometer networks. The database is now available to the scientific community through the Cluster Science Archive as auxiliary content. Based on the wave database, a statistical model of the wave activity dependent on the level of geomagnetic activity, solar wind forcing, and magnetospheric region has been developed. Multi-spacecraft particle measurements have been incorporated into data assimilation tools, leading to a more accurate estimate of the state of the radiation belts. The synergy of wave and particle observations is in the core of MAARBLE research studies of radiation belt dynamics. Results and conclusions from these studies will be presented in this paper. The MAARBLE (Monitoring, Analyzing and Assessing Radiation Belt Energization and Loss) collaborative research project has received funding from the European Unions Seventh Framework Programme (FP7-SPACE 2011-1) under grant agreement no. 284520. The complete MAARBLE Team: Ioannis A. Daglis, Sebastien Bourdarie, Richard B. Horne, Yuri Khotyaintsev, Ian R. Mann, Ondrej Santolik, Drew L. Turner, Georgios Balasis, Anastasios

  6. Gastric pentadecapeptide BPC 157 effective against serotonin syndrome in rats.


    Boban Blagaic, Alenka; Blagaic, Vladimir; Mirt, Mirela; Jelovac, Nikola; Dodig, Goran; Rucman, Rudolf; Petek, Marijan; Turkovic, Branko; Anic, Tomislav; Dubovecak, Miroslav; Staresinic, Mario; Seiwerth, Sven; Sikiric, Predrag


    Serotonin syndrome commonly follows irreversible monoamine oxidase (MAO)-inhibition and subsequent serotonin (5-HT) substrate (in rats with fore paw treading, hind limbs abduction, wet dog shake, hypothermia followed by hyperthermia). A stable gastric pentadecapeptide BPC 157 with very safe profile (inflammatory bowel disease clinical phase II, PL-10, PLD-116, PL-14736, Pliva) reduced the duration of immobility to a greater extent than imipramine, and, given peripherally, has region specific influence on brain 5-HT synthesis (alpha-[14C]methyl-L-tryptophan autoradiographic measurements) in rats, different from any other serotonergic drug. Thereby, we investigate this peptide (10 microg, 10 ng, 10 pg/kg i.p.) in (i) full serotonin syndrome in rat combining pargyline (irreversible MAO-inhibition; 75 mg/kg i.p.) and subsequent L-tryptophan (5-HT precursor; 100 mg/kg i.p.; BPC 157 as a co-treatment), or (ii, iii) using pargyline or L-tryptophan given separately, as a serotonin-substrate with (ii) pargyline (BPC 157 as a 15-min posttreatment) or as a potential serotonin syndrome inductor with (iii) L-tryptophan (BPC 157 as a 15 min-pretreatment). In all experiments, gastric pentadecapeptide BPC 157 contrasts with serotonin-syndrome either (i) presentation (i.e., particularly counteracted) or (ii) initiation (i.e., neither a serotonin substrate (counteraction of pargyline), nor an inductor for serotonin syndrome (no influence on L-tryptophan challenge)). Indicatively, severe serotonin syndrome in pargyline + L-tryptophan rats is considerably inhibited even by lower pentadecapeptide BPC 157 doses regimens (particularly disturbances such as hyperthermia and wet dog shake thought to be related to stimulation of 5-HT2A receptors), while the highest pentadecapeptide dose counteracts mild disturbances present in pargyline rats (mild hypothermia, feeble hind limbs abduction). Thereby, in severe serotonin syndrome, gastric pentadecapeptide BPC 157 (alone, no behavioral or

  7. President of Czech Republic visits ESO's Paranal Observatory

    NASA Astrophysics Data System (ADS)


    On 6 April 2011, the ESO Paranal Observatory was honoured with a visit from the President of the Czech Republic, Václav Klaus, and his wife Livia Klausová, who also took the opportunity to admire Cerro Armazones, the future site of the planned E-ELT. The distinguished visitor was shown the technical installations at the observatory, and was present when the dome of one of the four 8.2-metre Unit Telescopes of ESO's Very Large Telescope opened for a night's observing at Cerro Paranal, the world's most advanced visible-light observatory. "I'm delighted to welcome President Klaus to the Paranal Observatory and to show him first-hand the world-leading astronomical facility that ESO has designed, has built, and operates for European astronomy," said ESO's Director General, Tim de Zeeuw. President Klaus replied, "I am very impressed by the remarkable technology that ESO has built here in the heart of the desert. Czech astronomers are already making good use of these facilities and we look forward to having Czech industry and its scientific community contribute to the future E-ELT." From the VLT platform, the President had the opportunity to admire Cerro Armazones as well as other spectacular views of Chile's Atacama Desert surrounding Paranal. Adjacent to Cerro Paranal, Armazones has been chosen as the site for the future E-ELT (see eso1018). ESO is seeking approval from its governing bodies by the end of 2011 for the go-ahead for the 1-billion euro E-ELT. Construction is expected to begin in 2012 and the start of operations is planned for early in the next decade. President Klaus was accompanied by the Minister of Foreign Affairs of the Czech Republic, Karel Schwarzenberg, the Czech Ambassador in Chile, Zdenek Kubánek, dignitaries of the government, and a Czech industrial delegation. The group was hosted at Paranal by the ESO Director General, Tim de Zeeuw, the ESO Representative in Chile, Massimo Tarenghi, the Director of Operations, Andreas Kaufer, and Jan Palous

  8. Obituary: E. Dorrit Hoffleit, 1907-2007

    NASA Astrophysics Data System (ADS)

    Trimble, Virginia


    , began writing about eighty short news notes per year for Volumes 1-15 of the newly for med Sky & Telescope. And then there was a war. Women were not, of course, drafted nor required to find state-side war work to avoid deployment overseas, but Dorrit, still mindful of her German heritage, volunteered. After about six months working under Zdenek Kopal on preparation of firing tables for Navy cannons, she returned briefly to Harvard, having been employed (and paid) at roughly the high-school student level by the Navy. But soon it was on to the Ballistic Research Laboratory of the Army's Aberdeen Proving Ground and another computing job, this time for trajectories of anti-aircraft missiles. The other job opportunity was to measure missile tracks on photographic plates, which she would have preferred, but this would have placed her in the department headed by Edwin P. Hubble. No love was lost between Harvard's Shapley and Mount Wilson's Hubble, partly due to scientific differences, but also partly due to their very different views on what scientists should do in war time, so perhaps is was just as well she ended up in the computing section. There was another stage of fuss and bother to be got through before Dorrit received an appropriate, "professional" (meaning with PhD) rank and the commensurate salary. To the Colonel who complained that women were forever leaving their jobs to get married, she mentioned only her age, and not her early resolve never to marry or to have children, because of a deep worry that they might inherit the mental instability that had led to her maternal grandmother's institutionalization and early death. By the end of the war, her position, salary, and responsibilities a good match to her skills and credentials, Dorrit willingly put in another three years with the Army, working on reduction of records of "DOppler Velocity and Position" data for the captured V-2s being flown from White Sands Missile Range. But it was not the astronomy she loved, and

  9. Comet Hyakutake to Approach the Earth in Late March 1996

    NASA Astrophysics Data System (ADS)


    collisions of comets with the Earth may be found in an article by Zdenek Sekanina and Don Yeomans (Jet Propulsion Laboratory, CALTECH, Pasadena, U.S.A.) which appeared in 1984 in the American journal The Astronomical Journal , Volume 89, page 154. Notes: [1] Prominent examples are Comet Kohoutek in 1973 and Comet Austin in 1990. [2] 1 Astronomical Unit (AU) = 149.6 million kilometres (the mean distance between the Earth and the Sun). Note also that ESO has set up a special Home Page for the Comet Hyakutake event ( where new information from ESO will be brought.

  10. PREFACE: CEWQO Topical Issue CEWQO Topical Issue

    NASA Astrophysics Data System (ADS)

    Bozic, Mirjana; Man'ko, Margarita


    This topical issue of Physica Scripta collects selected peer-reviewed contributions based on invited and contributed talks and posters presented at the 15th Central European Workshop on Quantum Optics (CEWQO) which took place in Belgrade 29 May-3 June 2008 ( On behalf of the whole community took place in Belgrade 29 May-3 June 2008 (, On behalf of the whole community of the workshop, we thank the referees for their careful reading and useful suggestions which helped to improve all of the submitted papers. A brief description of CEWQO The Central European Workshop on Quantum Optics is a series of conferences started informally in Budapest in 1992. Sometimes small events transform into important conferences, as in the case of CEWQO. Professor Jozsef Janszky, from the Research Institute of Solid State Physics and Optics, is the founder of this series. Margarita Man'ko obtained the following information from Jozsef Janszky during her visit to Budapest, within the framework of cooperation between the Russian and Hungarian Academies of Sciences in 2005. He organized a small workshop on quantum optics in Budapest in 1992 with John Klauder as a main speaker. Then, bearing in mind that a year before Janszky himself was invited by Vladimir Buzek to give a seminar on the same topic in Bratislava, he decided to assign the name 'Central European Workshop on Quantum Optics', considering the seminar in Bratislava to be the first workshop and the one in Budapest the second. The third formal workshop took place in Bratislava in 1993 organized by Vladimir Buzek, then in 1994 (Budapest, by Jozsef Janszky), 1995 and 1996 (Budmerice, Slovakia, by Vladimir Buzek), 1997 (Prague, by Igor Jex), 1999 (Olomouc, Czech Republic, by Zdenek Hradil), 2000 (Balatonfüred, Hungary, by Jozsef Janszky ), 2001 (Prague, by Igor Jex), 2002 (Szeged, Hungary, by Mihaly Benedict), 2003 (Rostock,Germany, by Werner Vogel and

  11. Obituary: Brian Marsden (1937-2010)

    NASA Astrophysics Data System (ADS)

    Williams, Gareth; Marsden, Cynthia


    compute the orbits of comets. Recalling his earlier interest in Jupiter's moons, he completed the requirements for his Ph.D. degree with a thesis on "The Motions of the Galilean Satellites of Jupiter". At the invitation of director Fred Whipple, he joined the staff of the Smithsonian Astrophysical Observatory in Cambridge (MA) in 1965. Dr. Whipple was probably best known for devising the "dirty snowball" model for the nucleus of a comet a decade and a half earlier. At that time there was only rather limited evidence that the motion of a comet was affected by forces over and above those of gravitation (limited because of the need to compute the orbit by hand), and the Whipple model had it that those forces were due to the comet's reaction to vaporization of the cometary snow or ice by solar radiation. Dr. Marsden therefore developed a way to incorporate such forces directly into the equations that governed the motion of a comet. Application of a computer program that included these nongravitational effects to several comets soon gave results that were nicely compatible with Dr. Whipple's original idea. Continued refinement of the nongravitational terms, much of it done in collaboration with Zdenek Sekanina, a Czech astronomer and friend of Dr. Marsden whom he and Dr. Whipple succeeded in bringing to the U.S. as a refugee following the Soviet invasion of Prague in 1968, resulted in a wealth of improved computations of cometary orbits by the time Dr. Sekanina moved to California in 1980. It is noteworthy that the procedure devised and developed by Dr. Marsden is still widely used to compute the nongravitational effects of comets, with relatively little further modification by other astronomers. The involvement of the Smithsonian Astrophysical Observatory with comets had been given a boost, shortly before Dr. Marsden's arrival there, by the transfer there from Copenhagen of the office of the Central Bureau for Astronomical Telegrams, a quaintly named organization that was