Modified fluctuation-dissipation and Einstein relation at nonequilibrium steady states

NASA Astrophysics Data System (ADS)

Chaudhuri, Debasish; Chaudhuri, Abhishek

2012-02-01

Starting from the pioneering work of Agarwal [G. S. Agarwal, Zeitschrift für PhysikEPJAFV1434-600110.1007/BF01391621 252, 25 (1972)], we present a unified derivation of a number of modified fluctuation-dissipation relations (MFDR) that relate response to small perturbations around nonequilibrium steady states to steady-state correlations. Using this formalism we show the equivalence of velocity forms of MFDR derived using continuum Langevin and discrete master equation dynamics. The resulting additive correction to the Einstein relation is exemplified using a flashing ratchet model of molecular motors.

Republication of: On the general relativity theory

NASA Astrophysics Data System (ADS)

Weyl, H.

2009-07-01

This English translation of the paper by H. Weyl, "Zur allgemeinen Relativitätstheorie", Physikalische Zeitschrift 24, 230-232 (1923), in which he formulated the geometrical foundations of a model of an expanding Universe, has been selected by the Editors of General Relativity and Gravitation for publication in the Golden Oldies series of the journal. The paper is accompanied by an editorial note written by Juergen Ehlers and by Weyl's brief biography compiled by Andrzej Krasiński from internet sources, with corrections provided by Weyl's son and grandson.

PubMed

Hey, Christiane

2018-04-01

Bock JM et al. Evaluation of the natural history of patients who aspirate. Laryngoscope 2017; 127: S1–S10 DIE KLINISCHE PROGRESSION DER ASPIRATION BIS ZU EVENTUELLEN PULMONALEN STöRUNGEN IST NICHT VOLLSTäNDIG VERSTANDEN. EMPFEHLUNGEN ZUR ERNäHRUNGSUMSTELLUNG, SCHWERE VON PENETRATION UND ASPIRATION GEMäß PAS SOWIE DIE ÄTIOLOGIE DER DYSPHAGIE BEEINFLUSSEN MöGLICHERWEISE DIE ZEITSPANNE BIS ZUM AUFTRETEN DES ERSTEN PULMONALEN EREIGNISSES SOWIE DAS GESAMTüBERLEBEN VON PATIENTEN MIT VFS-DOKUMENTIERTER, ASYMPTOMATISCHER PENETRATION UND ASPIRATION.

Biokompatible Metalle

NASA Astrophysics Data System (ADS)

Ha, Suk-Woo; Wintermantel, Erich

Metalle als Implantatwerkstoffe werden in der Medizin für zwei Hauptanwendungen eingesetzt: für Prothesen des totalen Gelenkersatzes wie beispielsweise Hüft-, Knie- und Schulterprothesen und für Fixationselemente zur Stabilisierung von Frakturen. Beispiele hierfür sind Osteosyntheseplatten, Marknägel, Schrauben, Drähte und Stents. Eine der ersten Anwendungen von Metallen im menschlichen Körper war die Fixation von Fragmenten eines gebrochenen Humerus (Oberarmknochen) mit einem Metalldraht durch zwei französische Physiker im Jahr 1775 [1]. Ausführliche Untersuchungen zur Verträglichkeit von Metallen im menschlichen Körper wurden bereits im frühen 19. Jahrhundert durchgeführt. Von den untersuchten Werkstoffen verursachten die edlen Metalle wie Gold, Silber und Platin aufgrund ihrer Korrosionsbeständigkeit und Körperverträglichkeit die geringsten Reizungen im menschlichen Körper. Die klinische Anwendung der Edelmetalle war jedoch wegen der geringen mechanischen Eigenschaften beschränkt. Andere Metalle wie Messing, Kupfer oder Eisen wiesen vergleichsweise höhere Festigkeitswerte auf, sie waren jedoch aufgrund der geringen Korrosionsbeständigkeit und Biokompatibilität nicht für den klinischen Einsatz geeignet. Ein weiteres Problem stellte die Gefahr der Infektion durch unsterile Instrumente und Implantate dar. Gegen Ende des 19. Jahrhunderts hielt die antiseptische Operationsmethode Einzug in die Kliniken, die z. B. erfolgreiche Operationen mit Silberdraht ermöglichte.

The Open Access Model of Meteorologische Zeitschrift and other meteorological journals

NASA Astrophysics Data System (ADS)

Emeis, S.

2009-09-01

Today's availability and possibilities of the internet have already brought significant changes to the means of scientific communication. This also affects the publication and reception of peer-reviewed papers in scientific journals. In pre-internet times, the publication of scientific journals was mainly financed through subscription fees paid by libraries and other subscribers. The readers went to the libraries of their institution to search, read, and photocopy these papers. Today, everybody expects to have scientific papers more or less freely available on their desktop computers and from their printers. This has forced the publishers to change the financial model for the publication of scientific papers. An increasing number of journals now publish papers whose production costs have to be paid before the publication by the author or its institution. Those "pre-paid” papers are then freely available from the internet. This publication model has become known as "Open Access (OA)” model. Also the 126-year old Meteorologische Zeitschrift has changed its publication model to an Optional Open Access model. The features of this model will be presented and compared to other OA models with meteorological journals. This change in the publication models with a shift of its payment from the end (libraries and subscribers) to the beginning of the publication process (authors) has also confronted the scientific research and funding institutions with some problems. They must now also change their structures in financing one of their major outputs, the publications of their researchers. A few aspects of the present state of this shift will be addressed.

[COPD und Klangtherapie: Pilotstudie zur Wirksamkeit einer Behandlung mit Körpertambura bei COPD-Patienten].

PubMed

Hartwig, Bernhard; Schmidt, Stefan; Hartwig, Isabella

2016-01-01

Hintergrund: Erkrankungen der Atemorgane treten mit steigendem Alter öfter auf, nehmen weltweit zu und sind häufige Ursachen für Morbidität und Mortalität. In dieser Pilotstudie wurde der Frage nachgegangen, ob eine einmalige 10-minütige Behandlung mit einer Körpertambura eine signifikante und effektive Verbesserung der Lungenfunktion von Patienten mit chronisch-obstruktiver Lungenerkrankung (COPD; GOLD-Stadium A oder B) erbringen kann. Patienten und Methoden: 54 Probanden konnten je zur Hälfte in eine Behandlungsgruppe (Körpertambura) und eine aktive Kontrollgruppe (Atemtherapie) randomisiert werden. Eine Bestimmung der Lungenfunktionsmessparameter «Einsekundenkapazität» (FEV1) und «inspiratorische Vitalkapazität» (IVC) zu den Zeitpunkten T1 (Baseline), T2 (direkt nach Behandlung) und als Follow-up etwa 3 Wochen nach T1 (T3). Ergebnisse: Die Behandlungsgruppe zeigte sich der Kontrollgruppe in beiden Werten signifikant überlegen. Die Zeit-×-Gruppe-Interaktion (Varianzanalyse) ergab p = 0,001 (FEV1) bzw. p = 0,04 (IVC). Die Behandlungsgruppe zeigte bei beiden Werten eine Verbesserung von klinischer Relevanz. Schlussfolgerung: Diese Ergebnisse zeigen, dass die Klangbehandlung mittels einer Körpertambura - neben den schulmedizinischen, leitliniengerechten Therapien - eine zusätzliche, nebenwirkungsarme, aber durchaus klinisch wirksame Option für die Behandlung von COPD-Patienten darstellen kann, um deren Lebensqualität zu stabilisieren und zu verbessern. © 2016 S. Karger GmbH, Freiburg.

Retrospektive Analyse von Zufallsbefunden, die bei Patienten mit kutanem malignen Malignom durch (18) F-Fluordeoxyglucose-PET/CT erhoben wurden.

PubMed

Conrad, Franziska; Winkens, Thomas; Kaatz, Martin; Goetze, Steven; Freesmeyer, Martin

2016-08-01

Bei der (18) F-Fluordeoxyglucose-Positronenemissionstomographie/Computertomographie (FDG-PET/CT) ergeben sich häufig Zufallsbefunde. In der vorliegenden Studie konzentrierten wir uns auf mittels FDG-PET/CT erhaltene Zufallsbefunde bei Patienten mit kutanem Melanom und überprüften deren Relevanz hinsichtlich weiterer diagnostischer Maßnahmen und Interventionen. Die Krankenakten von 181 konsekutiven Melanom-Patienten wurden retrospektiv ausgewertet, um das Management von Zufallsbefunden zu dokumentieren. Der Schwerpunkt lag dabei auf den histologischen Befunden. Bei 33 von 181 (18 %) Patienten lagen 39 relevante Zufallsbefunde vor, und zwar im Kolorektalbereich (n = 15 Patienten), in der Schilddrüse (n = 8), der Prostata (n = 2), dem Bewegungsapparat (n = 2), in Lymphknoten (n = 2), der Parotis (n = 1), den Mandeln (n = 1), den Nieren (n = 1) und der Gallenblase (n = 1). Bei 25 Patienten schlossen sich weitere diagnostische Verfahren an, wobei in 21 Fällen ein klinisches Korrelat nachgewiesen wurde. Bei 16 von 21 Patienten ergab sich eine Neoplasie, darunter fünf maligne Läsionen (vier Kolonkarzinome und ein Prostatakarzinom). Die Malignome wurden frühzeitig diagnostiziert und in der Mehrzahl der Fälle erfolgreich entfernt. Der Einsatz der FDG-PET/CT als Routine-Diagnostik wird in den Leitlinien empfohlen und ist indiziert bei malignem Melanom ab Stadium IIC. In dieser Studie wurden auf effektive Weise ansonsten nicht erkannte Krebserkrankungen, insbesondere Kolonkarzinome, detektiert. In den meisten Fällen war eine frühe Intervention möglich. Zufallsbefunde durch FDG-PET/CT sollten, unter Berücksichtigung des Zustands und der Wünsche des Patienten, mit den geeigneten diagnostischen Maßnahmen abgeklärt werden. © 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Elastolysen und Hauterkrankungen mit Verlust der elastischen Fasern.

PubMed

Tronnier, Michael

2018-02-01

Die elastischen Fasern sind neben den kollagenen Fasern der wichtigste Bestandteil des Bindegewebsgerüstes der Haut. Eine Verminderung oder ein Verlust der elastischen Fasern ist bei einer Vielzahl von klinisch sich unterschiedlich präsentierenden Erkrankungen, hereditär oder erworben, beschrieben. Bei den Erkrankungen, die mit einer Entzündung einhergehen ist die Elastophagozytose ein wichtiges histologisches Merkmal. Die Therapie der Erkrankungen dieser Gruppe ist grundsätzlich schwierig. © 2018 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Tissue Engineering in der Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie

NASA Astrophysics Data System (ADS)

Bücheler, Markus; Bootz, Friedrich

Tissue Engineering ist eine Schlüsseltechnologie für den Gewebeersatz der Zukunft. Am Beispiel der Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie werden klinisch etablierte Gewebeersatzmethoden und aktuelle Entwicklungen des Tissue Engineering gegenübergestellt. Die Besonderheiten der zu ersetzenden Gewebe im Kopf- und Halsbereich erfordert vielfältige Ersatzverfahren. Im klinischen Alltag werden heute vor allem autogene Transplantate und Implantate für den Gewebeersatz verwendet [1]. In vitro hergestellte Gewebe werden abgesehen von Einzelanwendungen zur Zeit noch nicht am Patienten eingesetzt.

Spitznävi: unterschiedliche klinische, dermatoskopische und histopathologische Merkmale in der Kindheit.

PubMed

Dika, Emi; Neri, Iria; Fanti, Pier Alessandro; Barisani, Alessia; Ravaioli, Giulia Maria; Patrizi, Annalisa

2017-01-01

Die Charakterisierung der klinischen Merkmale und des biologischen Potenzials von Spitznävi hat in den letzten Jahrzehnten breites Interesse gefunden. Das Ziel dieser Arbeit ist die Beschreibung der klinischen und dermatoskopischen Merkmale von Spitznävi sowie des klinischen Ergebnisses nach chirurgischer Exzision von Spitznävi in drei pädiatrischen Altersgruppen. Restrospektive Studie zur Analyse von klinischen Merkmalen, videodermatoskopischen Bildern, histopathologischen Diagnosen und Behandlungsergebnissen. Der Grad der Pigmentierung wurde sowohl klinisch als auch histopathologisch beurteilt. Bei 71 Patienten wurden 72 spitzoide Neoplasien entfernt. Videodermatologische Bilder lagen für 41 Patienten vor. Das Muster der Pigmentierung korrelierte signifikant mit dem Alter der Patienten: Hyperpigmentierte Läsionen waren bei Vorschulkindern selten, bei Patienten von 7 bis 12 Jahren und ab 13 Jahren dagegen häufiger. Eine histopathologische Diagnose von atypischen Spitznävi wurde selten durchgeführt. Keiner der Patienten, bei denen ursprünglich ein atypischer Spitznävus diagnostiziert worden war, entwickelte ein Lokalrezidiv oder Metastasen während der anschließenden Nachbeobachtung. Pigmentierte Spitznävi traten im Alter ab 13 Jahren häufiger auf. Die Studie bestätigt andere Berichte über die Altersverteilung von Pigmentierungsmustern und hebt die geringe Anzahl atypischer Spitznävi bei pädiatrischen Patienten hervor sowie das Ausbleiben von Rezidiven bei der langfristigen Nachbeobachtung. © 2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Aufnahme, Analyse und Visualisierung von Bewegungen nativer Herzklappen in-vitro

NASA Astrophysics Data System (ADS)

Weiß, Oliver; Friedl, Sven; Kondruweit, Markus; Wittenberg, Thomas

Die hohe Zahl an Transplantationen von Herzklappen und viele nötige Re-Operationen machen eine detaillierte Analyse der Strömungen und Klappenbewegungen klinisch interessant. Ein neuer Ansatz ist hierbei der Einsatz von Hochgeschwindigkeitskameras um Bewegungsabl äufe der Herzklappen beobachten und auswerten zu können. Die hohen Datenraten erfordern allerdings eine möglichst automatisierte Analyse und möglichst komprimierte Darstellung des Schwingungsverhaltens. In dieser Arbeit wird ein Ansatz vorgestellt, bei dem Bewegungen nativer Herzklappen in-vitro aufgenommen, analysiert und kompakt visualisiert werden.

Book Review: Book review

NASA Astrophysics Data System (ADS)

Tweed, Fiona S.

2017-08-01

This special edition of Zeitschrift für Geomorphologie (ZfG) is based on presentations given at a conference entitled 'Hydrological Extreme Events in Historic and Prehistoric Times' which took place in Bonn in June 2014. The volume consists of an editorial introduction and nine research papers reflecting a range of approaches to understanding past events, including modelling, analysis of historical data and studies that focus on a consistent approach to collection and analysis of data from different areas. The HEX project, which generated the conference in Bonn, adopted a multidisciplinary approach and this is reflected in the collection of papers, which emphasise the importance of combining a range of approaches and analyses as tools for decoding both landscapes and processes.

Epidemiologie, Prävention und Früherkennung des Zervixkarzinoms

PubMed Central

Wentzensen, Nicolas

2016-01-01

Zusammenfassung Hintergrund Persistierende Infektionen mit humanen Papillomviren sind die notwendige Ursache des Zervixkarzinoms. Die Entwicklung von HPV-basierten Präventionsverfahren, der HPV Impfung und der HPV-Testung, führt derzeit zu umfangreichen Veränderungen von Zervixkarzinom-Vorsorgeprogrammen. Eine Dekade nach Einführung der HPV-Imfpung in vielen Ländern werden bereits Reduktionen von HPV-Infektionen und Krebsvorstufen in jungen Frauen beobachtet. Der Fokus liegt jetzt auf der Integration von neuen Testverfahren im Screening von Populationen mit zunehmenden Impfraten. Ergebnisse und Schlussfolgerung Ein erfolgreiches Zervixkarzinom-Vorsorgeprogramm besteht aus verschiedenen Komponenten, vom primären Screening über die Triage zur Kolposkopie mit Biopsie, um Frauen mit Kresbvorstufen zu identifizieren, die eine therapeutische Intervention benötigen. Im primären Screening wird eine kleine Gruppe von Frauen mit erhöhtem Risiko für eine Krebsvorstufe identifiziert, während die grosse Mehrheit kein erhöhtes Risiko hat. Je nach primärem Testverfahren werden in screen-positiven Frauen zusätzliche Triage-Tests durchgeführt, um zu entscheiden, wer zur Kolposkopie überwiesen werden sollte. Derzeit gibt es drei verschiedene Ansätze für das primäre Zervixkarzinomscreening: Die Zervix-Zytologie, die HPV-Testung, und die HPV-Zytologie Ko-Testung. Zahlreiche Triage-Tests für HPV-positive Frauen werden derzeit untersucht, darunter sind die Zytologie, HPV-Genotypisierung, p16/Ki-67 Zytologie, und diverse Methylierungstests. Die steigende Anzahl an Optionen für die Früherkennung des Zervixkarzinoms stellt eine Herausforderung für klinische Leitlinien dar. Die zunehmende Komplexität von Vorsorgeprogrammen kann zur Verunsicherung von Ärzten und von am Screening teilnehmenden Frauen führen. Die Präzisions-Prävention des Zervixkarzinoms ist eine neuer Ansatz, der umfangreiche Risikodaten basierend auf der individuellen Vorgeschichte und von Testergebnissen integriert und einheitliche, Risiko-basierte Managementempfehlungen gibt. PMID:28265177

Sleeping beauties in psychology: comparisons of "hits" and "missed signals" in psychological journals.

PubMed

Lange, Lydia L

2005-05-01

Scientific publications tend to be forgotten quickly. A few works, however, are still cited 100 years and more after their publication. The author used bibliometric methods to compare "hits" (works noticed by the scientific community soon after their publication) with "missed signals" (works that went unnoticed until much later) by investigating 2 psychological journals founded in the 1890s: Zeitschrift für Psychologie and Psychological Review. All articles that were published in either of these journals up to 1920 and cited more than 25 times in the Web of Science up to the year 2000 were considered for inclusion in the analysis. It emerged that hits corresponded more closely to the focus of scientific attention at the time of the publications than missed signals.

Intraläsionale Therapie niedrig maligner primär kutaner B-Zell-Lymphome mit Anti-CD20-Antikörper: Nebenwirkungen korrelieren mit gutem klinischen Ansprechen.

PubMed

Eberle, Franziska C; Holstein, Julia; Scheu, Alexander; Fend, Falko; Yazdi, Amir S

2017-03-01

Die intraläsionale Gabe von Anti-CD20-Antikörpern (Rituximab) wurde als effektive Therapieoption für Patienten mit niedrig malignen primär kutanen B-Zell-Lymphomen beschrieben. Bis heute wurden allerdings keine Parameter identifiziert, welche reproduzierbar ein gutes klinisches Ansprechen dieser Therapie vorhersagen. Ziel dieser Studie ist, sowohl das klinische Ansprechen und die unerwünschten Nebenwirkungen als auch die Patientenwahrnehmung hinsichtlich intraläsionaler Injektionen von anti-CD20-Antikörpern zur Behandlung indolenter primär kutaner B-Zell-Lymphome im Vergleich mit anderen Therapien zu evaluieren. Elf Patienten mit einem primär kutanen B-Zell-Lymphom, namentlich primär kutanes Keimzentrumslymphom (n = 9) und primär kutanes Marginalzonenlymphom (n = 2), welche mittels intraläsionalem Anti-CD20-Antikörper behandelt wurden, wurden retrospektiv evaluiert hinsichtlich der Ansprechrate und unerwünschter Nebenwirkungen sowie in Bezug auf deren Selbsteinschätzung dieser und anderer Therapien des primär kutanen B-Zell-Lymphoms. Patienten, deren primär kutanes B-Zell-Lymphom mittels intraläsionaler Gabe von Anti-CD20-Antikörper behandelt wurde, zeigten ein komplettes oder partielles Ansprechen in 45 % beziehungsweise 27 % aller Patienten. Speziell Patienten mit grippeähnlichen Symptomen nach erfolgter Injektion zeigten ein gutes Ansprechen. Die Mehrheit der Patienten empfand die Therapie mit Rituximab als die beste Therapie im Vergleich zu anderen Therapien wie beispielsweise chirurgische Exzision oder Radiotherapie. Intraläsionales Rituximab ist eine effektive Therapie mit hoher Patientenzufriedenheit. Starke therapiebedingte Nebenwirkungen wie Fieber, Schüttelfrost und Kopfschmerzen nach Gabe von Rituximab könnten als Indikator für gute Wirksamkeit dienen. © 2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Antibakterielle In-vitro-Wirksamkeit ätherischer Öle gegen veterinärmedizinisch relevante Keime klinischer Isolate von Hunden, Katzen und Pferden.

PubMed

Bismarck, Doris; Schneider, Marianne; Müller, Elisabeth

Einleitung: Ätherische Öle sind die Grundlage der Aromatherapie. Unter anderem wird ihnen eine antibakterielle Wirkung zugeschrieben. In dieser Studie sollte die In-vitro-Wirksamkeit ätherischer Öle gegen ein breites Spektrum veterinärmedizinisch relevanter Erreger getestet werden. Methoden: Die antibakterielle Aktivität von 16 ätherischen Ölen wurde mittels Agardiffusionstest bestimmt. Getestet wurden grampositive und gramnegative Erreger, die aus klinischen Isolaten von Hunden, Katzen und Pferden aus der veterinärmedizinischen Routinediagnostik stammten. Die Einteilung der Wirksamkeit in nicht, gering-, mittel- und hochgradig wirksam erfolgte anhand der Größe der Hemmhofradien des Bakterienwachstums. Ergebnisse: Generell zeigten sich sowohl grampositive als auch gramnegative Erreger empfindlich gegen einige der getesteten ätherischen Öle. Nicht nur gegen Staphylokokken, sondern auch gegen Methicillin-resistente Stämme der Staphylokokken wiesen die ätherischen Öle in vitro eine nicht zu vernachlässigende Wirkung auf. Pasteurella multocida stellte sich als eher sensibler Keim heraus, während Pseudomonas aeruginosa als vollkommen resistenter Keim eine Ausnahme bildete. Teebaum-, Oregano-, und Bergbohnenkrautöl waren die potentesten Öle. Zusätzlich zeigten sich bei den grampositiven Erregern Lemongrasöl und bei den gramnegativen Erregern Thymianöl als gut wirksam. Schlussfolgerung: Ätherische Öle verfügen in vitro über eine antibakterielle Aktivität gegen klinische Isolate von Hunden, Katzen und Pferden. Diese Studie bietet eine Grundlage für die Anwendung ätherischer Öle in der Veterinärmedizin. Es zeichneten sich Tendenzen im Wirkspektrum einzelner ätherischer Öle bzw. im Grad der Wirksamkeit ätherischer Öle hinsichtlich einzelner Erregerspezies ab, allerdings lässt sich keine sichere Vorhersage über ihre Wirksamkeit gegen einen spezifischen Keim eines individuellen Patienten treffen. Deswegen sollte vor einer Therapie mit ätherischen Ölen deren individuelle Wirksamkeit mittels Aromatogramm getestet werden. © 2017 The Author(s). Published by S. Karger GmbH, Freiburg.

[Is evidence-based assessment fact or fiction? A bibliometric analysis of three German journals].

PubMed

Petermann, Franz; Schüssler, Gerhard; Glaesmer, Heide

2008-01-01

Despite the ongoing process for the development and dissemination of empirically supported treatments, little attention has been paid to the development of evidence-based diagnostics. The article aims at evaluating diagnostic procedures and instruments in current clinical research in terms of evidence-based assessment. Volumes 2006 and 2007 of three German psychological journals "Psychotherapeut," "Psychotherapie, Psychosomatik und Medizinische Psychologie," and "Zeitschrift für Psychiatrie, Psychologie und Psychotherapie" were screened for empirical reports and articles dealing with diagnostic issues. 93 articles were identified and evaluated. Most studies used psychometrically valid and established instruments for assessment. However, diagnostic interviews were relatively scarce, as were multimodal assessments. Measures used for outcome evaluation often lacked evidence of sensitivity to change. Clinical assessment to date does not meet criteria for evidence-based diagnostics. Implications for research and guideline development are discussed.

Vernarbende Alopezien.

PubMed

Kanti, Varvara; Röwert-Huber, Joachim; Vogt, Annika; Blume-Peytavi, Ulrike

2018-04-01

Primär vernarbende Alopezien (PVA) werden nach der Klassifikation der North American Hair Research Society nach ihrem prominenten entzündlichen Infiltrat in vier Gruppen eingeteilt: PVA mit lymphozytärem, neutrophilem, gemischtzelligem oder unspezifischem Entzündungsmuster. Der Haarausfall kann subklinisch beginnen und langsam fortschreiten, so dass der genaue Erkrankungsbeginn oft schwer nachzuvollziehen ist. Die Diagnose wird häufig verzögert gestellt. Während die meisten vernarbenden Alopezien bei vollständiger Ausprägung anhand des klinischen Bildes klar zugeordnet werden können, ist die Diagnosestellung in der Frühphase oder im Endstadium häufig schwierig. Bei Erstvorstellung sollte eine ausführliche Anamnese und dermatologische Ganzkörperuntersuchung, inklusive Trichoskopie durchgeführt werden. In klinisch unklaren Fällen sollte eine Biopsie erfolgen. Aufgrund der Seltenheit der PVA gibt es bisher nur eine niedrige Evidenz über die Wirksamkeiten der Vielzahl der verschiedenen angewandten Therapien. Ziele der Therapie einer PVA sind, den Haarausfall zu stoppen oder zumindest zu verzögern, die klinischen Entzündungszeichen zu reduzieren, weitere Vernarbung zu verhindern sowie die subjektiven Symptome zu lindern. Ein Nachwachsen in bereits vernarbten Arealen sollte nicht erwartet werden. Eine antientzündliche Therapie mit topischen Kortikosteroiden der Klasse III-IV und/oder mit intrakutanen intraläsionalen Triamcinolonacetonid-Injektionen kommt bei den meisten PVA in Betracht. Die Wahl der systemischen Therapie hängt von der Art des prädominierenden entzündlichen Infiltrates ab und umfasst antimikrobielle/antibiotische oder immunmodulatorische/immunsuppressive Ansätze. Psychologische Unterstützung und Camouflage-Techniken sollten den Patienten angeboten werden. © 2018 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Wolves, dogs, rearing and reinforcement: complex interactions underlying species differences in training and problem-solving performance.

PubMed

Frank, Harry

2011-11-01

Frank and Frank et al. (1982-1987) administered a series of age-graded training and problem-solving tasks to samples of Eastern timber wolf (C. lupus lycaon) and Alaskan Malamute (C. familiaris) pups to test Frank's (Zeitschrift für Tierpsychologie 53:389-399, 1980) model of the evolution of information processing under conditions of natural and artificial selection. Results confirmed the model's prediction that wolves should perform better than dogs on problem-solving tasks and that dogs should perform better than wolves on training tasks. Further data collected at the University of Connecticut in 1983 revealed a more complex and refined picture, indicating that species differences can be mediated by a number of factors influencing wolf performance, including socialization regimen (hand-rearing vs. mother-rearing), interactive effects of socialization on the efficacy of both rewards and punishments, and the flexibility to select learning strategies that experimenters might not anticipate.

Progress in superconductivity: The Indian Scenario

NASA Technical Reports Server (NTRS)

Multani, Manu; Mishra, V. K.

1995-01-01

India has made rapid progress in the field of high temperature superconductivity, beginning at the time of publication of the Zeitschrift fur Physik paper by Bednorz and Muller. Phase 1 of the program was conceived by the Department of Science & Technology of the Government of India. It consisted of 42 projects in the area of basic research, 23 projects in applications and 4 short-term demonstration studies. The second phase started in October 1991 and will run through March 1995. It consists of 50 basic research programs and 24 application programs. The total investment, mainly consisting of infrastructural development to supplement existing facilities and hiring younger people, has amounted to about Indian Rupees 40 crores, equivalent to about US$ 13 million. The expenditure for the period 1992-1997 shall be up to about Rs. 27 crores, equivalent to about US$ 9 million. The basic idea is to keep pace with developments around the world.

[The Coordinating Centers for Clinical Trials (KKS) and the KKS Network: competence for clinical research].

PubMed

Ohmann, Christian; Bruns, Insa; Wolff, Stephanie

2010-01-01

The Network of the Coordination Centers for Clinical Trials (CTCs; Koordinierungszentren für Klinische Studien(KKS)) comprises 17 institutions working as scientific service provider for universities, study groups, the pharmaceutical and medical devices industry as well as additional clients associated with clinical research. The CTCs have established planning and conduct of clinical trials according to Good Clinical Practice (GCP) guidelines,with a wide range of study support in academia. One focus according to indications is cancer. Expertise in hematological/oncological research can be requested nationwide and cross-institutional. The KKS network currently cooperates with medical societies and other, even European networks in 20 countries and has been established as a strong platform for oncological trials. Copyright © 2010 S. Karger AG, Basel.

Recovering Ancient Inscriptions by X-ray Fluorescence Imaging

NASA Astrophysics Data System (ADS)

Powers, Judson; Dimitrova, Nora; Huang, Rong; Smilgies, Detlef-M.; Bilderback, Don; Clinton, Kevin; Thorne, Robert

2006-03-01

For many ancient cultures including those of the Mediterranean, carved stone inscriptions provide our most detailed historical record. Over the ages the surfaces of many of these inscriptions have been eroded so that the original text can no longer be distinguished. A method that allowed at least partial recovery of this lost text would provide a major breakthrough for the study of these cultures. The scope of analytical techniques that can be applied to stone tablets is limited by their large size and weight. We have applied X-ray fluorescence imaging to study the text of ancient stone inscriptions [1]. This method allows the concentrations of trace elements, including those introduced during inscription and painting, to be measured and mapped. The images created in this way correspond exactly to the published text of the inscription, both when traces of letters are visible with the naked eye and when they are barely detectable. [1] J. Powers et al., Zeitschrift für Papyrologie und Epigraphik 152: 221-227 (2005).

Developmental psychopathology: Attention Deficit Hyperactivity Disorder (ADHD).

PubMed

Schmidt, Sören; Petermann, Franz

2009-09-17

Attention Deficit/Hyperactivity Disorder (ADHD), formerly regarded as a typical childhood disorder, is now known as a developmental disorder persisting over the lifespan. Starting in preschool-age, symptoms vary depending on the age group affected. According to the variability of ADHD-symptoms and the heterogeneity of comorbid psychiatric disorders, a broad review of recent studies was performed. These findings were summarized in a developmental psychopathological model, documenting relevant facts on a timeline. Based on a genetic disposition and a neuropsychological deregulation, there is evidence for factors which persist across the lifespan, change age-dependently, or show validity in a specific developmental phase. Qualitative changes can be found for children in preschool-age and adults. These differences have implications for clinical practice as they can be used for prevention, diagnostic proceedings, and therapeutic intervention as well as for planning future studies. The present article is a translated and modified version of the German article "Entwicklungspsychopathologie der ADHS", published in Zeitschrift für Psychiatrie, Psychologie und Psychotherapie, 56, 2008, S. 265-274.

Stereopsis and positional acuity under dark adaptation.

PubMed

Livingstone, M S; Hubel, D H

1994-03-01

Though experience tells us we can perceive depth in dim light, it is not so obvious that one of the chief mechanisms for depth perception, stereopsis, is possible under scotopic conditions. The only studies on human stereopsis in the dark adapted state seem to be those of Nagel [(1902) Zeitschrift für Psychologie, 27, 264-266] and Mueller and Lloyd [(1948) Proceedings of the National Academy of Science, U.S.A., 34, 223-227], both of which used real objects or line stereograms. We tested stereopsis using both random-dot and line stereograms and, in agreement with these studies, found that stereopsis is indeed possible in dark adaptation. We also measured stereo acuity and positional acuity (both of which are examples of hyperacuity) and compared these with grating acuity at several levels of light and dark adaptation. At all illumination levels tested, acuities for stereopsis and relative line position were both higher than for grating acuity. As light levels decreased, positional and grating acuity declined in parallel fashion, whereas stereoacuity declined more steeply.

A review and reanalysis of Bruno Schulz's "Erkrankungsalter schizophrener Eltern und Kinder [Age at onset of illness in schizophrenic parents and offspring]:" Zeitschrift für die gesamte Neurologie und Psychiatrie, 168, 709-721, 1940.

PubMed

Sham, P C; Zerbin-Rüdin, E; Kendler, K S

1995-01-01

Nearly all previous evidence of the familial transmission of age at onset of schizophrenia has been in siblings and twins. In his paper, Bruno Schulz examined the age at onset distribution of schizophrenia in affected parent and offspring pairs, using a systematic series of ascertained cases (n = 106), as well as a second series of chronic in-patients (n = 36). The parent-offspring correlation in age at onset, for cases with a definite diagnosis in the systematically ascertained series, was estimated at 0.346 (95% confidence interval 0.134, 0.528). Schulz did not test for differences between the two series and between males and females, but our reanalysis, using correlational methods and a mixed linear model, did not detect any significant differences. These results are consistent with previous findings that age at onset of schizophrenia is influenced by familial factors which may be genetic.

A review of Edward Flatau's 1894 Atlas of the Human Brain by the neurologist Sigmund Freud.

PubMed

Triarhou, Lazaros C

2011-01-01

In 1894, the Polish neurologist Edward Flatau (1868-1932), working in Berlin, published an exquisite photographic atlas of the unfixed human brain, preceding by 2 years Das Menschenhirn, the reference work of Gustaf Retzius (1842-1919) in Stockholm. In his early career as a neuroanatomist and neurologist, Sigmund Freud (1856-1939) wrote a review of Flatau's atlas for the Internationale klinische Rundschau, which has not been included in the 'Standard Edition of the Complete Psychological Works'. The aim of the present paper is twofold: to document Freud's review, and to revive the largely forgotten atlas of Flatau. The full text of Freud is presented in translation. Further, one element Flatau, Retzius and Freud had in common is discussed: their early role as protagonists and firm supporters of Ramón y Cajal's neuron theory, the cornerstone of modern neuroscience. Copyright © 2010 S. Karger AG, Basel.

[Willy Hellpach's (1877-1955) Medical Psychology].

PubMed

Huppmann, Gernot

2004-01-01

In Germany Medical Psychology was commonly understood as Psychopathology until the mid-20th century. Especially Ernst Kretschmer (1888-1964) and Paul Schilder (1886-1964) can be named as authors who contributed to this particular field representing a basis of psychiatry. With his textbook 'Klinische Psychologie' published in 1946, Willy Hellpach (1877-1955), a neuropsychiatrist and professor of psychology, established a new understanding of this part of Applied Psychology. His statement: "All forms of mental behaviour in somatic diseases are subject of Clinical Psychology " has fallen into oblivion. Although presented as Clinical Psychology has conception is basically medical-psychological. We intend to outline Hellpach's biography and to describe - thereafter - the development of his Clinical, i.e. Medical Psychology and its subjects. We hope that medical psychologists, especially in Germany, but in other countries, too, will absorb Hellpach's ideas and will begin to appreciate his importance for the configuration of a modern Medical Psychology.

Bildanalyse in Medizin und Biologie

NASA Astrophysics Data System (ADS)

Athelogou, Maria; Schönmeyer, Ralf; Schmidt, Günther; Schäpe, Arno; Baatz, Martin; Binnig, Gerd

Heutzutage sind bildgebende Verfahren aus medizinischen Untersuchungen nicht mehr wegzudenken. Diverse Methoden - basierend auf dem Einsatz von Ultraschallwellen, Röntgenstrahlung, Magnetfeldern oder Lichtstrahlen - werden dabei spezifisch eingesetzt und liefern umfangreiches Datenmaterial über den Körper und sein Inneres. Anhand von Mikroskopieaufnahmen aus Biopsien können darüber hinaus Daten über die morphologische Eigenschaften von Körpergeweben gewonnen werden. Aus der Analyse all dieser unterschiedlichen Arten von Informationen und unter Konsultation weiterer klinischer Untersuchungen aus diversen medizinischen Disziplinen kann unter Berücksichtigung von Anamnesedaten ein "Gesamtbild“ des Gesundheitszustands eines Patienten erstellt werden. Durch die Flut der erzeugten Bilddaten kommt der Bildverarbeitung im Allgemeinen und der Bildanalyse im Besonderen eine immer wichtigere Rolle zu. Gerade im Bereich der Diagnoseunterstützung, der Therapieplanung und der bildgeführten Chirurgie bilden sie Schlüsseltechnologien, die den Forschritt nicht nur auf diesen Gebieten maßgeblich vorantreiben.

Developmental psychopathology: Attention Deficit Hyperactivity Disorder (ADHD)

PubMed Central

Schmidt, Sören; Petermann, Franz

2009-01-01

Background Attention Deficit/Hyperactivity Disorder (ADHD), formerly regarded as a typical childhood disorder, is now known as a developmental disorder persisting over the lifespan. Starting in preschool-age, symptoms vary depending on the age group affected. Method According to the variability of ADHD-symptoms and the heterogeneity of comorbid psychiatric disorders, a broad review of recent studies was performed. These findings were summarized in a developmental psychopathological model, documenting relevant facts on a timeline. Results Based on a genetic disposition and a neuropsychological deregulation, there is evidence for factors which persist across the lifespan, change age-dependently, or show validity in a specific developmental phase. Qualitative changes can be found for children in preschool-age and adults. Conclusion These differences have implications for clinical practice as they can be used for prevention, diagnostic proceedings, and therapeutic intervention as well as for planning future studies. The present article is a translated and modified version of the German article "Entwicklungspsychopathologie der ADHS", published in Zeitschrift für Psychiatrie, Psychologie und Psychotherapie, 56, 2008, S. 265-274. PMID:19761584

Entropy for quantum pure states and quantum H theorem

NASA Astrophysics Data System (ADS)

Han, Xizhi; Wu, Biao

2015-06-01

We construct a complete set of Wannier functions that are localized at both given positions and momenta. This allows us to introduce the quantum phase space, onto which a quantum pure state can be mapped unitarily. Using its probability distribution in quantum phase space, we define an entropy for a quantum pure state. We prove an inequality regarding the long-time behavior of our entropy's fluctuation. For a typical initial state, this inequality indicates that our entropy can relax dynamically to a maximized value and stay there most of time with small fluctuations. This result echoes the quantum H theorem proved by von Neumann [Zeitschrift für Physik 57, 30 (1929), 10.1007/BF01339852]. Our entropy is different from the standard von Neumann entropy, which is always zero for quantum pure states. According to our definition, a system always has bigger entropy than its subsystem even when the system is described by a pure state. As the construction of the Wannier basis can be implemented numerically, the dynamical evolution of our entropy is illustrated with an example.

[Specific immunotherapy. Hyposensitization with allergens].

PubMed

Wedi, B; Kapp, A

2004-04-01

Successful allergen-specific immunotherapy (SIT) induces complex immunologic chan-ges resulting in reduced allergic inflammatory reactions. SIT has long-term effects in mild forms of inhalant allergies and is effective even when standard pharmacotherapy fails. Moreover, the risk to develop additional allergic sensitizations and the development of asthma is significantly reduced in children with allergic rhinitis. SIT is the treatment of choice in patients with systemic reactions to hymenoptera venoms. Although the exact effector mechanisms of SIT still have to be clarified, the most probable effect is a modulation of regulatory T cells associated with a switch of allergen-specific B-cells towards IgG4 production. The critical point to insure efficacy and safety is the selection of patients and allergens, task best performed by a specialist trained in allergology. Further details are available in the position papers of the German allergy societies - DGAI(Deutsche Gesellschaft fiir Allergologie und Klinische Immunologie) and ADA (Arzte-verband Deutscher Allergologen) - which can be found at www.dgaki.de.

On raising the international dissemination of German research: Does changing publication language to English attract foreign authors to publish in a German basic psychology research journal?

PubMed

Dinkel, Andreas; Berth, Hendrik; Borkenhagen, Ada; Brähler, Elmar

2004-01-01

It has been proposed that German basic psychology journals should change publication language to English in order to facilitate access to research from German-speaking countries. However, to truly increase the dissemination of German research, it seems crucial to progress towards an internationalization of authors and readers. We applied bibliometric analysis to investigate the impact of the transition to English on the rate of foreign authors publishing in Zeitschrift für Experimentelle Psychologie/Experimental Psychology, as well as possible associated changes in citation patterns. There was an increase in the rate of articles published by foreign authors from 14.6 and 8.7 per cent, respectively, for the last biannual periods as German-language journal, to 52.7 per cent in the first biannual period as English-language journal. Regarding citations patterns, the clearest changes emerged for domestic authors. The results illustrate possible consequences of a transition to English as publication language, and reveal that Experimental Psychology has successfully established certain prerequisites for an increase of the international dissemination of German psychology research.

Articulation effects in lightness: historical background and theoretical implications.

PubMed

Gilchrist, Alan L; Annan, Vidal

2002-01-01

The concept of articulation was first introduced by Katz [1935 The World of Colour (London: Kegan Paul, Trench, Trubner & Co)] to refer to the degree of complexity within a field. Katz, who created the basic research methods for studying lightness constancy, found that the greater the degree of articulation within a field of illumination, the greater the degree of constancy. Even though this concept has been largely forgotten, there is much empirical evidence for Katz's principle, and the effects on lightness are very strong. However, when articulation is increased within a framework that does not coincide with a region of illumination, constancy is weakened. Kardos (1934 Zeitschrift für Psychologie Ergänzungband 23) advanced the concept of co-determination, according to which the lightness of a surface is determined relative to more than one field of illumination. Gilchrist et al (1999 Psychological Review 106 795-834) argue that the fields concept should be replaced by the more operational frameworks concept and that a wide variety of lightness errors can be explained by a modification of the Katz principle: the greater the articulation within a perceptual framework, the stronger the anchoring of lightness values within that framework.

New technique for ensemble dressing combining Multimodel SuperEnsemble and precipitation PDF

NASA Astrophysics Data System (ADS)

Cane, D.; Milelli, M.

2009-09-01

The Multimodel SuperEnsemble technique (Krishnamurti et al., Science 285, 1548-1550, 1999) is a postprocessing method for the estimation of weather forecast parameters reducing direct model output errors. It differs from other ensemble analysis techniques by the use of an adequate weighting of the input forecast models to obtain a combined estimation of meteorological parameters. Weights are calculated by least-square minimization of the difference between the model and the observed field during a so-called training period. Although it can be applied successfully on the continuous parameters like temperature, humidity, wind speed and mean sea level pressure (Cane and Milelli, Meteorologische Zeitschrift, 15, 2, 2006), the Multimodel SuperEnsemble gives good results also when applied on the precipitation, a parameter quite difficult to handle with standard post-processing methods. Here we present our methodology for the Multimodel precipitation forecasts applied on a wide spectrum of results over Piemonte very dense non-GTS weather station network. We will focus particularly on an accurate statistical method for bias correction and on the ensemble dressing in agreement with the observed precipitation forecast-conditioned PDF. Acknowledgement: this work is supported by the Italian Civil Defence Department.

Transplantate und Implantate im Mittelohrbereich - Teil 1 (Stand 2002)

NASA Astrophysics Data System (ADS)

Kempf, Hans-Georg; Lenarz, Thomas; Eckert, Karl-Ludwig

In Deutschland leben ungefähr 12 Millionen Menschen, die an einer ein- oder beidseitigen Schwerhörigkeit leiden. Diese kann angeboren oder im Laufe des Lebens erworben sein. Klinisch und therapeutisch wichtig ist die Unterscheidung, ob die Ursache der Schwerhörigkeit im Bereich des Mittelohres, d. h. der Schallübertragung, oder im Bereich des Innenohres, der Hörnerven und der zentralen Hörbahnabschnitte, d. h. der Schallempfindung, liegt. 2,5 Millionen Schwerhörige haben dabei das Problem der Schallübertragung, d.h. die Störung liegt im Mittelohrbereich, und hier kann man in der Regel mit operativen, mikrochirurgisch durchgeführten Massnahmen helfen [1, 2]. Im Vordergrund steht als Ursache hier die chronische Mittelohrentzündung, die sich als Perforation des Trommelfells, als Defekt oder Unterbrechung der Gehörknöchelchen oder auch als Cholesteatom, einer sogenannte Knocheneiterung äussern kann [3]. Therapeutisch und damit als Prinzip der operativen Hörverbesserung steht primär der Verschluss des Trommelfells oder eine Rekonstruktion der Gehörknöchelchen an.

[Officer in charge, that unknown being - an explorative, qualitative study of unconscious fears, wishes, and defense mechanisms].

PubMed

Beck, Thomas; Kumnig, Martin; Breuss, Margit; Mitmansgruber, Horst; Schusser, Sandra; Andreatta, Pia; Mader, Maria; Schüßler, Gerhard

2013-01-01

The stress and coping strategies found among emergency relief personnel have been studied in detail but without considering their function in the team. However, specifically officers in charge have to be addressed and investigated separately. This study focuses on the unconscious desires, fears, and defense mechanisms present in order to improve our understanding of the stress experienced during operations. Four officers in charge were interviewed concerning their stressful experiences during operations. These interviews were then coded and analysed using the JAKOB Narrative Analysis ("Klinische Erzählanalyse JAKOB", Boothe et al. 2002). The recorded unconscious desires included solidarity, phallic integrity, generativity, unconscious fears destruction, loss of power/influence, and social hostility, and as defense strategies rationalism, repression/denial, and idealization. The analysis of the interviews shows a high reliability between the raters (0.74-0.79). The greatest burden for officers in charge is a loss of safety. Especially being confronted with strains in their own team leads to stress, which shows that the methods used for stress management following critical incidents is not sufficient.

[Osteopathie bei gastroösophagealem Reflux mit Hiatushernie: Ein Fallbericht gemäß der CARE-Leitlinie].

PubMed

Rotter, Gabriele; Brinkhaus, Benno

2017-01-01

Hintergrund: Das Vorhandensein einer Hiatushernie kann das Auftreten einer gastroösophagealen Refluxerkrankung (GERD) als Komplikation bedingen. Konventionelle medizinische Therapiemaßnahmen können zu unerwünschten Ereignissen und Rezidiven führen. Bisher sind die Effekte von osteopathischen Behandlungen bei Hiatushernie und GERD nicht bekannt. Fallbericht: Eine 59-jährige Patientin mit endoskopisch diagnostizierter chronischer Gastritis, GERD und Hiatushernie beklagte einen persistierenden gastroösophagealen Reflux trotz konventionell-medizinischer konservativer Therapie. Die osteopathische Diagnostik ergab eine funktionelle Störung im Bereich des Magens und der Kardia mit einer Beteiligung zugehöriger Reflexzonen. Nach einer osteopathischen Behandlung als individuelle, befundorientierte Therapie ließen die Beschwerden erheblich nach. Die Hiatushernie war nach einer dieser Behandlung endoskopisch nicht mehr nachweisbar. Schlussfolgerungen: Dieser Fallbericht schildert die Symptomreduktion einer GERD nach osteopathischer Behandlung. In der endoskopischen Folgeuntersuchung fand sich die initial diagnostizierte Hiatushernie nicht mehr, diese Befund änderung könnte jedoch auf die unterschiedlichen Untersucher zurückgeführt werden. Prospektive kontrollierte klinische Studien sind notwendig, um den Stellenwert von osteopathischen Behandlungen bei GERD mit Hiatushernie zu untersuchen. © 2017 The Author(s). Published by S. Karger GmbH, Freiburg.

Einleitung

NASA Astrophysics Data System (ADS)

Ha, Suk-Woo; Wintermantel, Erich

Der Aufbau des menschlichen Körpers ist derart komplex, dass die vollständige funktionelle Substitution seiner Strukturen mit künstlichen Werkstoffen und Bauteilen unwahrscheinlich ist. Die meisten heute klinisch eingesetzten Implantate ersetzen in der Regel einfache mechanische oder andere physikalische Funktionen des menschlichen Körpers, die aufgrund eines singulären Defektes im Gewebe oder als Ergebnis einer chronischen Erkrankung substituiert werden müssen. Gelenkprothesen beispielsweise übertragen Lasten, eine künstliche intraokulare Linse ermöglicht Lichttransmission und eine künstliche Arterie sorgt für die Aufrechterhaltung der Blutversorgung. Neben der Funktionserfüllung müssen die medizinisch eingesetzten Werkstoffe zusätzlich den Anforderungen der Körperverträglichkeit genügen, die die vollständige und dauerhafte Aufnahme des Implantates im Körper zum Ziel hat. Die Erkenntnisse der Werkstoffwissenschaft und deren Umsetzung in neue Produkte hat die Entwicklung und Fortschritte in der Medizin und in der Chirurgie entscheidend geprägt. Werkstoffe stehen in ihrem klinischen Einsatz als Temporärimplantate (z. B. Kathetersysteme) sowie als Langzeitimplantate (z. B. Hüftgelenksimplantate oder Herzschrittmacher) in direktem Kontakt mit den Geweben des Körpers und müssen deshalb biokompatibel sein.

Medizintechnik in der Tumororthopädie

NASA Astrophysics Data System (ADS)

Burgkart, Rainer; Gollwitzer, Hans; Holzapfel, Boris; Rudert, Maximilian; Rechl, Hans; Gradinger, Reiner

Die Behandlung der Knochentumoren unterlag in den letzten 20 Jahren einem raschen und stetigen Wandel, was zum einen auf die verbesserten Therapieerfolge durch den Einsatz von neoadjuvanten Therapieformen zurückzuführen ist, und andererseits von medizintechnischen Entwicklungen bezüglich moderner Schnittbilddiagnostik, neuer 3D Operationsplanungsverfahren wie das Rapid Prototyping und adaptiv modularer Tumorendoprothesensystemen u. a. begleitet wurde. Gerade die technischen Entwicklungen haben dazu geführt, daß im Bereich der Extremitäten und der Wirbelsäule radikalere Eingriffe durchgeführt werden können, was die lokale Tumorkontrolle wesentlich verbessert hat. In zunehmenden Maße werden deshalb nicht nur Kurzzeiterfolge sondern auch mittel- und langfristige Fortschritte bei der Behandlung der malignen Knochentumoren einschließlich der Metastasenbehandlung erreicht. Grundlage der Therapie ist dabei immer primär die Sicherung der Diagnose mittels Biopsie und die bildgebende sowie histologische Stadieneinteilung des malignen Tumors. Nach der Tumorresektion kann die Rekonstruktion biologisch oder mit Endoprothesensystemen erfolgen. Gerade die weiterentwickelten modularen Systeme führen zu guten funktionellen Ergebnissen mit langen Standzeiten und einer reduzierten Komplikationsrate. Individuell angefertigte Implantate sind vor allem im Bereich der Rekonstruktion komplexer Beckentumoren von großer klinischer Bedeutung.

Implantate für den Bandscheibenersatz (Stand 1993)

NASA Astrophysics Data System (ADS)

Mathey, Michael; Wintermantel, Erich

Die Bandscheiben sind besonders betroffen von Fehlhaltungen und -stellungen der Wirbelsäule. Sie unterliegen als grösstes zusammenhängendes, nicht vaskularisiertes Gewebe im Menschen, statisch und dynamisch extrem belastet, besonders der Alterung. Um die teilweise sehr starken Schmerzen bei Bandscheibenschädigungen zu lindern, ist eine Operation vielfach die einzige Hilfe. Bei dieser Operation (Nukleotomie) entfernt man das aus der Bandscheibe ausgetretene Gewebe des Gallertkerns (nucleus pulposus), welches durch Druck auf die Nervenstränge im Bereich der Wirbelsäule die Beschwerden (Ischias-Schmerz) verursacht hat. Nach der Entfernung des Gallertkerns werden die auftretenden Kräfte bei veränderter Biomechanik übertragen. Dabei erhalten die Zwischenwirbelgelenke (Facettengelenke) eine erheblich grössere Flächenpressung als dies bei intakter Bandscheibe der Fall war. Die höhere Flächenpressung kommt durch die Verringerung des Abstandes zwischen den oberen und unteren Deckplatten der benachbarten Wirbelkörper zustande, zwischen denen sich der Gallertkern befand. Durch geeignetes Training der Rückenmuskulatur kann eine Stabilisierung des operierten Bandscheibensegmentes erreicht werden, jedoch ist es eine klinische Erfahrung, dass die meisten Patienten, die momentan durch die Operation schmerzfrei geworden sind, keine adäquate zusätzliche sportliche Betätigung auf sich nehmen.

Working with Instruments: Ernst Mach as Material Epistemologist, a Short Introduction.

PubMed

Hoffmann, Christoph; Métraux, Alexandre

2016-12-01

With the death of Ernst Mach on February 19, 1916, one day after his seventy-eighth birthday, a question finally became explicit that had been looming for some time. It was as simple as it was fundamental: who, in the end, was this man, a scientist or a philosopher? The importance of this question for contemporaries can easily be gleaned from the obituaries that appeared in the weeks following Mach's death: one in the Physikalische Zeitschrift, written by Albert Einstein, and another in the Archiv für die Geschichte der Philosophie, written by Mach's former student Heinrich Gomperz. They both addressed this critical issue in plain words. Einstein stressed that Mach "was not a philosopher who chose the natural sciences as the object of his speculation, but a many-sided, interested, diligent scientist who also took visible pleasure in detailed questions outside the burning issues of general interest" (Einstein 1916, 104; translation cited in Blackmore 1992, 158). Gomperz in turn first emphasized the great loss science had experienced with Mach's death, asking subsequently whether "the suffering science is physics or philosophy?" (Gomperz 1916, 321). His answer broadly followed Einstein's conclusion; relying on Mach's own words, he reminded his readers that Mach never claimed to be a philosopher, but merely was looking for a viewpoint that transcended the disciplinary constraints of particular scientific activities.

The perception of object versus objectless motion.

PubMed

Hock, Howard S; Nichols, David F

2013-05-01

Wertheimer, M. (Zeitschrift für Psychologie und Physiologie der Sinnesorgane, 61:161-265, 1912) classical distinction between beta (object) and phi (objectless) motion is elaborated here in a series of experiments concerning competition between two qualitatively different motion percepts, induced by sequential changes in luminance for two-dimensional geometric objects composed of rectangular surfaces. One of these percepts is of spreading-luminance motion that continuously sweeps across the entire object; it exhibits shape invariance and is perceived most strongly for fast speeds. Significantly for the characterization of phi as objectless motion, the spreading luminance does not involve surface boundaries or any other feature; the percept is driven solely by spatiotemporal changes in luminance. Alternatively, and for relatively slow speeds, a discrete series of edge motions can be perceived in the direction opposite to spreading-luminance motion. Akin to beta motion, the edges appear to move through intermediate positions within the object's changing surfaces. Significantly for the characterization of beta as object motion, edge motion exhibits shape dependence and is based on the detection of oppositely signed changes in contrast (i.e., counterchange) for features essential to the determination of an object's shape, the boundaries separating its surfaces. These results are consistent with area MT neurons that differ with respect to speed preference Newsome et al (Journal of Neurophysiology, 55:1340-1351, 1986) and shape dependence Zeki (Journal of Physiology, 236:549-573, 1974).

„3D-augmented-reality“-Visualisierung für die navigierte Osteosynthese von Beckenfrakturen

PubMed Central

Befrui, N.; Fischer, M.; Fuerst, B.; Lee, S.-C.; Fotouhi, J.; Weidert, S.; Johnson, A.; Euler, E.; Osgood, G.; Navab, N.; Böcker, W.

2018-01-01

Zusammenfassung Hintergrund Trotz großer Fortschritte in der Entwicklung der Hard- und Software von Navigationssystemen finden diese aufgrund ihrer vermeintlichen Komplexität, umständlichen Integration in klinische Arbeitsabläufe und fraglichen Vorteilen gegenüber konventionellen bildgebenden Verfahren bisher wenig Einsatz in den heutigen Operationssälen. Ziel der Arbeit Entwicklung einer „Augmented-reality“(AR)-Darstellung zur chirurgischen Navigation ohne Infrarot(„IR“)-Tracking-Marker und Vergleich zum konventioneller Röntgen in einem simulierten Eingriff. Material und Methoden Navigationssystem bestehend aus „Cone-beam-CT“(CBCT)-fähigem C-Bogen und „Red-green-blue-depth“(RGBD)-Kamera. Testung durch Kirschner(K)-Draht-Platzierung in Modellen unter Berücksichtigung der benötigten Zeit, der Strahlendosis und der Benutzerfreundlichkeit der Systeme. Ergebnisse Eine signifikante Reduktion der benötigten Zeit, der Röntgenbilder und der gesamten Strahlendosis bei der AR-Navigation gegenüber dem konventionellen Röntgen bei gleichbleibender Präzision. Schlussfolgerung Die AR-Navigation mithilfe der RGBD-Kamera bietet flexible und intuitive Darstellungsmöglichkeiten des Operations-situs für navigierte Osteosynthesen ohne Tracking-Marker. Hiermit ist es möglich, Operationen schneller, einfacher und mit geringerer Strahlenbelastung für Patient und OP-Personal durchzuführen. PMID:29500506

[The effect of mood-stabilising drugs on cytokine levels in bipolar disorder: a systematic review].

PubMed

Van Den Ameele, S; van Diermen, L; Staels, W; Coppens, V; Dumont, G; Sabbe, B; Morrens, M

Veranderde cytokineconcentraties bij personen met een bipolaire stoornis ten opzichte van controle-personen suggereren een rol van het immuunsysteem in de pathofysiologie van bipolaire stoornis. Farmacotherapie is een belangrijke verstorende factor in klinisch onderzoek naar cytokineconcentraties.
DOEL: Evalueren van cytokineconcentraties bij medicatievrije patiënten met een bipolaire stoornis en van het effect van stemmingsstabiliserende geneesmiddelen op deze concentraties.
METHODE: We doorzochten systematisch PubMed en Embase naar klinische studies die cytokineconcentraties bij medicatievrije patiënten met een bipolaire stoornis beschrijven of het effect van een individueel stemmingsstabiliserend geneesmiddel op deze concentraties evalueren.
RESULTATEN: Van de 564 gescreende artikelen werden er 17 geïncludeerd. Resultaten bij medicatievrije patiënten toonden stemmingsgerelateerde cytokineveranderingen. Hoewel geen data over de kortetermijneffecten van lithium beschikbaar waren, was lithiumgebruik langer dan 2 maanden geassocieerd met normale cytokineconcentraties. Twee studies rapporteerden geen effect van valproïnezuur. We vonden geen studies over carbamazepine, lamotrigine of antipsychotica.
CONCLUSIE: Dit systematisch literatuuroverzicht toont stemmingsgerelateerde cytokineveranderingen bij medicatievrije patiënten met een bipolaire stoornis met de meeste evidentie voor een pro-inflammatoire immuunrespons tijdens manie. Euthymie en langdurig lithiumgebruik zijn geassocieerd met normale cytokineconcentraties. Er is een belangrijke methodologische heterogeniteit en onvoldoende replicatie tussen studies. Longitudinale studies met medicatievrije beginmetingen, gerandomiseerde monotherapeutische behandelprotocollen en nauwkeurige monitoring van stemming zijn noodzakelijk.
BACKGROUND: Alterations of the cytokine level in persons with bipolar disorder - when compared to controls - suggest that the immune system plays a role in the pathophysiology of bipolar disorder. Pharmacotherapy is an important confounding factor in clinical research on cytokine levels.
AIM: To evaluate the evidence on cytokine levels in medication-free bipolar disorder and to study the effects that single mood-stabilising drugs have on these levels.
METHOD: We searched PubMed and Embase systematically in order to single out clinical studies that reported on cytokine levels in medication-free bipolar disorder or that commented on the effects of single mood-stabilising drugs on cytokine levels.
RESULTS: Of the 564 articles that we screened, we detected 17 that were particularly relevant for our investigation. Results for medication-free patients point to mood-related alterations in cytokine levels. Although we found no data relating to short-term effects of lithium, the use of lithium in euthymic populations was associated with normal cytokine levels. Two studies reported no effect of valproate. We did not find any studies relating to carbamazepine, lamotrigine or antipsychotics.
CONCLUSION: Our systematic review of the literature suggests the presence of mood-related changes in cytokine levels in medication-free patients with bipolar disorder, with the most evidence for a proinflammatory response during a manic episode. Euthymia and long-term use of lithium use are associated with normal cytokine levels. There is considerable heterogeneity in the methods used in these studies and too little replication. Future research will have to include longitudinal studies with medication-free baseline measurements. It will also be necessary to draw up single-drug treatment protocols and to conduct intensive mood-related monitoring.

The Original Michaelis Constant: Translation of the 1913 Michaelis-Menten Paper

PubMed Central

Johnson, Kenneth A.; Goody, Roger S.

2011-01-01

Nearly 100 years ago Michaelis and Menten published their now classic paper (Michaelis, L., and Menten, M. L. (1913) Die Kinetik der Invertinwirkung, Biochemische Zeitschrift 49, 333–369), in which they show that the rate of an enzyme-catalyzed reaction is proportional to the concentration of enzyme-substrate complex predicted by the Michaelis-Menten equation. Because the original text was written in German, yet is often quoted by English speaking authors, we undertook a complete translation of the 1913 publication, which we provide as an online supplement (http://pubs.acs.org). Here we introduce the translation, describe the historical context of the work, and show a new analysis of the original data. In doing so, we uncovered several surprises that reveal an interesting glimpse into the early history of enzymology. In particular, our re-analysis of Michaelis and Menten’s data using modern computational methods revealed an unanticipated rigor and precision in the original publication and uncovered a sophisticated, comprehensive analysis that has been overlooked in the century since their work was published. Michaelis and Menten not only analyzed initial velocity measurements, but they also fit their full time course data to the integrated form of the rate equations, including product inhibition, and derived a single global constant to represent all of their data. That constant was not the Michaelis constant, but rather, Vmax/Km, the specificity constant times the enzyme concentration (kcat/Km*E0). PMID:21888353

Deciding what to see: the role of intention and attention in the perception of apparent motion.

PubMed

Kohler, Axel; Haddad, Leila; Singer, Wolf; Muckli, Lars

2008-03-01

Apparent motion is an illusory perception of movement that can be induced by alternating presentations of static objects. Already in Wertheimer's early investigation of the phenomenon [Wertheimer, M. (1912). Experimentelle Studien über das Sehen von Bewegung. Zeitschrift fur Psychologie, 61, 161-265], he mentions that voluntary attention can influence the way in which an ambiguous apparent motion display is perceived. But until now, few studies have investigated how strong the modulation of apparent motion through attention can be under different stimulus and task conditions. We used bistable motion quartets of two different sizes, where the perception of vertical and horizontal motion is equally likely. Eleven observers participated in two experiments. In Experiment 1, participants were instructed to either (a) hold the current movement direction as long as possible, (b) passively view the stimulus, or (c) switch the movement directions as quickly as possible. With the respective instructions, observers could almost double phase durations in (a) and more than halve durations in (c) relative to the passive condition. This modulation effect was stronger for the large quartets. In Experiment 2, observers' attention was diverted from the stimulus by a detection task at fixation while they still had to report their conscious perception. This manipulation prolonged dominance durations for up to 100%. The experiments reveal a high susceptibility of ambiguous apparent motion to attentional modulation. We discuss how feature- and space-based attention mechanisms might contribute to those effects.

Are children's faces really more appealing than those of adults? Testing the baby schema hypothesis beyond infancy.

PubMed

Luo, Li Zhu; Li, Hong; Lee, Kang

2011-09-01

This study examined adults' evaluations of likeability and attractiveness of children's faces from infancy to early childhood. We tested whether Lorenz's baby schema hypothesis (Zeitschrift für Tierpsychologie (1943), Vol. 5, pp. 235-409) is applicable not only to infant faces but also to faces of children at older ages. Adult participants were asked to evaluate children's faces from early infancy to 6 years of age in terms of their likeability and attractiveness, and these judgments were compared with those of adult faces. It was revealed that adults judged faces of younger children as more likeable and attractive than faces of older children, which were in turn judged as more likeable and attractive than adult faces. However, after approximately 4.5 years of age, the baby schema no longer affected adults' judgments of children's facial likeability and attractiveness. These findings suggest that the baby schema affects adults' judgments of not only infant faces but also young children's faces. This influence beyond infancy is likely due to the fact that facial cranial growth is gradual during early childhood and certain crucial infantile facial cues remain readily available during this period. Future studies need to identify these specific cues to better understand why adults generally show positive responses to infantile faces and how such positive responses influence the establishment and maintenance of social relationships between young children and adults. Copyright © 2011 Elsevier Inc. All rights reserved.

In all questions, my interest is not in the individual people but in the analytic movement as a whole. It will be hard enough here in Europe in the times to come to keep it going. After all, we are just a handful of people who really have that in mind.

PubMed

Steiner, Riccardo

2011-06-01

The paper tries to deal with the difficult and at times contradictory decisions that the then leaders of the IPA, S. Freud, A. Freud, E. Jones etc. had to adopt as whether or not to clearly inform the readers of Die Internationale Zeitschrift für Psychoanalyse and the International Journal of Psychoanalysis, the official scientific periodicals of the IPA, of the tragic events concerning first the German Psychoanalytic Society and then the Vienna Psychoanalytic Society and the newborn Italian Psychoanalytic Society and other European psychoanalytic societies during the years 1933-1945. Because of the anti-Jewish persecution by the Nazi and fascist regimes the IPA had to face the extremely difficult task of helping its Continental Jewish members to emigrate to the USA, Great Britain and other countries in order to save their lives and to allow psychoanalysis to survive, with enormous radical consequences for the scientific and sociocultural future developments of the discipline.The following notes are dedicated to those non-Aryans and Aryans who could not find a proper rescue and whose graves became the wind which scattered the ashes of their bodies with the smoke coming out of the chimneys of the Nazi gas chambers. Copyright © 2011 Institute of Psychoanalysis.

Using quantum erasure to exorcize Maxwell's demon: I. Concepts and context

NASA Astrophysics Data System (ADS)

Scully, Marlan O.; Rostovtsev, Yuri; Sariyanni, Zoe-Elizabeth; Suhail Zubairy, M.

2005-10-01

Szilard [L. Szilard, Zeitschrift für Physik, 53 (1929) 840] made a decisive step toward solving the Maxwell demon problem by introducing and analyzing the single atom heat engine. Bennett [Sci. Am. 255 (1987) 107] completed the solution by pointing out that there must be an entropy, ΔS=kln2, generated as the result of information erased on each cycle. Nevertheless, others have disagreed. For example, philosophers such as Popper “have found the literature surrounding Maxwell's demon deeply problematic.” We propose and analyze a new kind of single atom quantum heat engine which allows us to resolve the Maxwell demon paradox simply, and without invoking the notions of information or entropy. The energy source of the present quantum engine [Scully, Phys. Rev. Lett. 87 (2001) 22601] is a Stern-Gerlach apparatus acting as a demonesque heat sorter. An isothermal compressor acts as the entropy sink. In order to complete a thermodynamic cycle, an energy of ΔW=kTln2 must be expended. This energy is essentially a “reset” or “eraser” energy. Thus Bennett's entropy ΔS=ΔW/T emerges as a simple consequence of the quantum thermodynamics of our heat engine. It would seem that quantum mechanics contains the kernel of information entropy at its very core. That is the concept of information erasure as it appears in quantum mechanics [Scully and Drühl, Phys. Rev. A 25 (1982) 2208] and the present quantum heat engine have a deep common origin.

Advice to young behavioral and cognitive scientists.

PubMed

Weisman, Ronald G

2008-02-01

Modeled on Medawar's Advice to a Young Scientist [Medawar, P.B., 1979. Advice to a Young Scientist. Basic Books, New York], this article provides advice to behavioral and cognitive scientists. An important guiding principle is that the study of comparative cognition and behavior are natural sciences tasked with explaining nature. The author advises young scientists to begin with a natural phenomenon and then bring it into the laboratory, rather than beginning in the laboratory and hoping for an application in nature. He suggests collaboration as a way to include research outside the scientist's normal competence. He then discusses several guides to good science. These guides include Tinbergen's [Tinbergen, N., 1963. On aims and methods of ethology. Zeitschrift für Tierpsychologie, 20, 410-433. This journal was renamed Ethology in 1986. Also reprinted in Anim. Biol. 55, 297-321, 2005] four "why" questions, Platt's [Platt, J.R., 1964. Strong inference. Science 146, 347-353, (http://weber.ucsd.edu/~jmoore/courses/Platt1964.pdf)] notion of strong inference using multiple alternative hypotheses, and the idea that positive controls help scientists to follow Popper's [Popper, K.R., 1959. The Logic of Scientific Discovery. Basic Books, New York, p. 41] advice about disproving hypotheses. The author also recommends Strunk and White's [Strunk, W., White, E.B., 1979. The Elements of Style, third ed. Macmillan, New York] rules for sound writing, and he provides his personal advice on how to use the anticipation of peer review to improve research and how to decode editors' and reviewers' comments about submitted articles.

Implantate im Mittelohrbereich - Teil 2 (Ergänzungen 2007)

NASA Astrophysics Data System (ADS)

Stieve, M.; Lenarz, Thomas

In Deutschland leben ca. 12 Millionen Menschen, die an einer ein- oder beidseitigen Schwerhörigkeit leiden. Diese kann angeboren oder im Laufe des Lebens erworben sein. Klinisch und therapeutisch wichtig ist die Unterscheidung hinsichtlich des Schädigungsortes im Bereich des Mittelohres, d. h. eine Schalleitungsschwerhörigkeit, oder im Bereich des Innenohres, d. h. eine Schallempfindungsschwerhörigkeit, wobei hier der Schädigungsort auch am Hörnerven oder in den zentralen Hörabschnitten liegen kann. Therapeutisch lassen sich sowohl Schwerhörigkeiten im Bereich des Mittelohres als auch im Innenohr und sogar im Hirnstammbereich (Hirnstammimplantat) behandeln. 1,9 Millionen Schwerhörige haben eine Erkrankung im Mittelohrbereich, d. h. der Schall kann nur ungenügend auf das Innenohr übertragen werden. Die Ursache besteht meist in einer chronischen Mittelohrentzündung, die zu einer Zerstörung des Trommelfells und der Gehörknöchelchenkette geführt haben. Therapeutisch und damit als Prinzip der operativen Hörverbesserung steht primär der Verschluß des Trommelfells oder eine Rekonstruktion der Gehörknöchelchen. Mittelohroperationen werden mikrochirurgisch unter dem Operationsmikroskop durchgeführt, wobei zunächst durch eine sanierende Operation der Entzündungsprozeß entfernt wird und nach einer Ausheilungszeit die Gehörknöchelchenkette durch künstliche Prothesen rekonstruiert werden kann.

Update zum klinischen Einsatz von Inhibitoren mutierter Phosphokinasen beim Melanom.

PubMed

Cosgarea, Ioana; Ritter, Cathrin; Becker, Jürgen C; Schadendorf, Dirk; Ugurel, Selma

2017-09-01

Die Behandlungsstrategie beim metastasierten Melanom hat sich mit der Identifizierung therapeutisch angreifbarer molekularer Zielstrukturen innerhalb zellulärer Signalwege radikal geändert. Durch die Zulassung von Substanzen, die gezielt an den zentralen Schaltmolekülen, den Phosphokinasen, angreifen, können diese Signalwege selektiv abgeschaltet werden. Dies ist insbesondere bei denjenigen Tumoren von Interesse, deren Signalwege durch aktivierende Mutationen der für die Schaltmoleküle kodierenden Gene konstitutiv aktiviert sind. Aktuell ist diese therapeutische Strategie insbesondere für Patienten bedeutsam, deren Melanome eine Mutation im BRAF-Gen aufweisen. Diese Patienten können durch eine Kombinationstherapie aus Inhibitoren der Phosphokinasen BRAF und MEK langfristig mit sehr guter Krankheitskontrolle behandelt werden. Unter dieser Kombinationstherapie wird aktuell ein progressionsfreies Überleben von über zehn Monaten und ein Gesamtüberleben von mehr als zwei Jahren bei guter Lebensqualität erzielt. Da unter längerfristiger Therapie mit Kinaseinhibitoren jedoch bei einem Großteil der Patienten eine Resistenzbildung auftritt, sind aktuelle klinische Therapiestudien auf die Suche nach geeigneten Kombinationspartnern unter Blockierung anderer Signalwege oder unter Aktivierung der T-Zell-vermittelten Immunantwort ausgerichtet. Der vorliegende Übersichtsartikel stellt sowohl die aktuell verfügbaren als auch die in der klinischen Testung befindlichen zukünftigen Optionen der zielgerichteten Therapie des Melanoms dar. © 2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Predictive Validity of the HKT-R Risk Assessment Tool: Two and 5-Year Violent Recidivism in a Nationwide Sample of Dutch Forensic Psychiatric Patients.

PubMed

Bogaerts, Stefan; Spreen, Marinus; Ter Horst, Paul; Gerlsma, Coby

2018-06-01

This study has examined the predictive validity of the Historical Clinical Future [ Historisch Klinisch Toekomst] Revised risk assessment scheme in a cohort of 347 forensic psychiatric patients, which were discharged between 2004 and 2008 from any of 12 highly secure forensic centers in the Netherlands. Predictive validity was measured 2 and 5 years after release. Official reconviction data obtained from the Dutch Ministry of Security and Justice were used as outcome measures. Violent reoffending within 2 and 5 years after discharge was assessed. With regard to violent reoffending, results indicated that the predictive validity of the Historical domain was modest for 2 (area under the curve [AUC] = .75) and 5 (AUC = .74) years. The predictive validity of the Clinical domain was marginal for 2 (admission: AUC = .62; discharge: AUC = .63) and 5 (admission: AUC = .69; discharge: AUC = .62) years after release. The predictive validity of the Future domain was modest (AUC = .71) for 2 years and low for 5 (AUC = .58) years. The total score of the instrument was modest for 2 years (AUC = .78) and marginal for 5 (AUC = .68) years. Finally, the Final Risk Judgment was modest for 2 years (AUC = .78) and marginal for 5 (AUC = .63) years time at risk. It is concluded that this risk assessment instrument appears to be a satisfactory instrument for risk assessment.

Investigations and results concerning railway-induced ground-borne vibrations in Germany

NASA Astrophysics Data System (ADS)

Degen, K. G.; Behr, W.; Grütz, H.-P.

2006-06-01

Besides noise reduction, ground-borne vibrations induced by railways are another important environmental issue associated with the construction of new or the reconstruction of existing railway lines that had to be tackled during the last decade. Annoyance can occur, particularly for lines in urban areas at small distances to neighbouring houses or lines in shallow depth tunnels under buildings. The ground-borne vibrations can be perceived by the inhabitants via the floor vibrations, as well as via the air-borne noise radiated inside the building by the vibrating building structures (secondary noise). At present, legal specifications for judging railway-induced ground-borne vibrations do not exist in Germany. In order to review common practices, an experimental psycho-physical laboratory study was performed. To estimate the annoyance of railway-induced vibrations, the mean vibration energy of a train pass-by seems much more significant and related to the annoyance than the commonly used RMS value according to the German standard DIN 4150-2. The minimum difference in vibration that can be felt by people was found at a signal difference of 25%. This paper will review results of a project performed in cooperation with the engineering office Obermeyer in Munich and the Technical University of Munich [A. Said, D. Fleischer, H. Kilcher, H. Fastl, H.-P. Grütz, Zur Bewertung von Erschütterungsimmissionen aus dem Schienenverkehr, Zeitschrift fuer Lärmbekämpfung, Vol. 48(6), Springer VDI Verlag, Düsseldorf, 2001.] and will link them to further demands on research and on development of suitable guiding principles and legislative regulations.

[German neurology and neurologists during the Third Reich: Preconditions and general framework before and after 1933].

PubMed

Martin, M; Karenberg, A; Fangerau, H

2016-08-01

This article focuses on the institutional development of neurology in Germany up to the rise to power of the National Socialists and the radical sociopolitical changes after 1933. A wide range of scattered secondary literature was assessed and evaluated. Additionally, some original sources are literally quoted and interpreted according to the context. Since the end of the nineteenth century a complicated process of separation from internal medicine and psychiatry led to the formation of a self-conscious discipline of neurology. The first generation of German neurologists succeeded in founding the German Journal for Neurology ("Deutsche Zeitschrift für Nervenheilkunde") in 1890 and their own neurological association, the Society of German Neurologists ("Gesellschaft Deutscher Nervenärzte", GDN) in 1907. On an international scale, however, the institutional implementation of neurology with only a small number of chairs and few neurology departments remained more than modest. The ambitions for autonomy ended 2 years after the change of power in 1933. Regulatory interventions by the government and psychiatric interests led to the fusion of the GDN with the psychiatric specialist society, the new association being called the Society of German Neurologists and Psychiatrists ("Gesellschaft Deutscher Neurologen und Psychiater", GDNP) in 1935. In this group psychiatrists dominated the discourse. The expulsion, imprisonment and murder of physicians declared as non-Aryan or Jewish along with the forced consolidation ("Gleichschaltung") at the universities prompted profound changes in medical and academic life. It remains an ongoing challenge of neurological historical research to measure the impact of this upheaval on the few neurology departments in hospitals and private practices.

[Advertising and Zeitgeist. The advertising of Schwabe Pharmaceuticals].

PubMed

Hofmann, Cornelia; Riha, Ortrun

2015-01-01

This contribution explores the advertisements for homeopathic products in magazines in the first half of the twentieth century, focusing on the period between 1933 and 1945 and based on the example of the pharmaceutical company Dr Willmar Schwabe. In the first half of the twentieth century, Schwabe Pharmaceuticals was market leader for homeopathic and other complementary medical products (phytotherapy, biochemicals). The example chosen as well as the time frame complement the existing research. We searched three German publications (the homeopathy journal Leipziger Populäre Zeitschrift für Homöopathie, the medical weekly Münchner Medizinische Wochenschrift and the pharma magazine Pharmazeutische Zeitung) and collected target-group-specific results for laypersons, physicians and pharmacists. Analysis of the images and texts in the selected advertisements often reflected the historical background and the respective health policies (wartime requirements, times of need, "Neue Deutsche Heilkunde"). The history of this traditional company was seen as an important point in advertising, as were the recognisability of the brand through the company logo, the emphasis on the high quality of their products and the reference to the company's own research activities. We furthermore found the kind of argumentation that is typical of natural medicine (naturalness, the power of the sun, prominent representatives). Schwabe met the expectations of its clients, who were interested in complementary medicine, whilst pursuing an approach to homeopathy that was compatible with natural science, and it presented itself as a modern, scientifically oriented enterprise. The company did not lose credibility as a result, but increased its clientele by expanding to include the whole naturopathic market.

[The company Willmar Schwabe in the Nazi era].

PubMed

Friedrich, Christoph; Meyer, Ulrich; Seyfang, Caroline

2016-01-01

This essay follows the history of the Schwabe Company between 1933 and 1945 when it, like all other companies at the time, had to subject to the state-enforced conformity ('Gleichschaltung'). While Willmar Schwabe II (1878-1935), the company's second director, kept clear of Nazi politics, both of his sons, who succeeded him at an early age, became members of the Nazi party: Willmar III (1907-1983) probably from initial conviction and Wolfgang (1912-2000), who joined in 1937, more likely for opportunistic reasons. The two lay journals published by Schwabe--the Leipziger Populäre Zeitschrift für Homöopathie and the Biochemische Monatsblätter--embraced the Nazi ideology more thoroughly than the general homeopathic journal Allgemeine Homöopathische Zeitung, including above all contributions on racial hygiene. Our research has revealed that Schwabe only employed foreign workers from 1942 on, that their number was much lower, at 0.9 per cent in 1942 and 3.6 per cent in 1944, than that of other pharmaceutical companies and that their pay hardly differed from that of German workers. The sales and profit figures investigated have shown that the company did not profit exceptionally from the new Nazi health policies ('Neue Deutsche Heilkunde'): while its sales and profits rose in the Nazi era due to the increased use of medication among the civil population during wartime, the drugs produced by Schwabe remained marginal also during the war, as is apparent also from its modest deliveries to the army. All in all one can conclude that the company offered neither resistance nor particular support to the Nazi ideology.

B-Zell-Lymphome der Haut - Pathogenese, Diagnostik und Therapie.

PubMed

Nicolay, Jan P; Wobser, Marion

2016-12-01

Primär kutane B-Zell-Lymphome (PCBCL) beschreiben reifzellige lymphoproliferative Erkrankungen der B-Zell-Reihe, die primär die Haut betreffen. Die Biologie und der klinische Verlauf der einzelnen PCBCL-Subtypen variieren untereinander stark und unterscheiden sich grundsätzlich von primär nodalen und systemischen B-Zell-Lymphomen. Primär kutane Marginalzonenlymphome (PCMZL) und primäre kutane follikuläre Keimzentrumslymphome (PCFCL) werden auf Grund ihres unkomplizierten Verlaufs und ihrer exzellenten Prognose zu den indolenten PCBCL gezählt. Demgegenüber stellen die diffus großzelligen B-Zell-Lymphome, hauptsächlich vom Beintyp (DLBCL, LT) die aggressiveren PCBCL-Varianten mit schlechterer Prognose dar. Für die Ausbreitungsdiagnostik und die Therapieentscheidung sind eine genaue histologische und immunhistochemische Klassifizierung sowie der Ausschluss einer systemischen Beteiligung in Abgrenzung zu nodalen oder systemischen Lymphomen notwendig. Die Diagnostik sollte dabei durch molekularbiologische Untersuchungen unterstützt werden. Therapeutisch stehen für die indolenten PCBCL primär operative und radioonkologische Maßnahmen im Vordergrund sowie eine Systemtherapie mit dem CD20-Antikörper Rituximab bei disseminiertem Befall. Die aggressiveren Varianten sollten in erster Linie mit Kombinationen aus Rituximab und Polychemotherapieschemata wie z. B. dem CHOP-Schema oder Modifikationen davon behandelt werden. Auf Grund der in allen seinen Einzelheiten noch nicht vollständig verstandenen Pathogenese und Biologie sowie des begrenzten Therapiespektrums der PCBCL besteht hier, speziell beim DLBCL, LT, noch erheblicher Forschungsbedarf. © 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Gerbstoffe aus Potentilla officinalis wirken entzündungshemmend im UV-Erythem-Test und bei Anwendung auf atopischer Haut.

PubMed

Hoffmann, Julia; Wölfle, Ute; Schempp, Christoph M; Casetti, Federica

2016-09-01

Das Rhizom von Potentilla officinalis (PO) ist reich an Gerbstoffen und wird traditionell zur äußerlichen Behandlung von Entzündungen der Haut und der Schleimhäute verwendet. Ziel der vorliegenden Arbeit war die Bestätigung der antiinflammatorischen Eigenschaften von PO mittels eines UV-Erythem-Tests und einer klinischen Anwendungsstudie bei atopischer Haut. Die antiinflammatorische Wirkung eines PO-Extrakts (standardisiert auf 2 % Trockensubstanz) wurde in einer prospektiven, randomisierten, placebokontrollierten Doppelblindstudie mit 40 gesunden Erwachsenen im UV-Erythem-Test im Vergleich zu 1 % Hydrocortisonacetat untersucht. Im Rahmen einer prospektiven nicht kontrollierten Studie wurde die Wirkung und Verträglichkeit der 2 % PO-Creme an zwölf Erwachsenen und zwölf Kindern mit atopischer Haut nach Anwendung über zwei Wochen in einem definierten Testareal anhand eines Teil-SCORAD untersucht. Zusätzlich wurde die Beeinflussung der Hautrötung im Testareal photometrisch gemessen. Im UV-Erythem-Test zeigte die PO-Creme eine signifikante Reduktion des Erythemindex im Vergleich zum Vehikel. Die antiinflammatorische Wirkung des Verums entsprach der der 1 % Hydrocortisonacetat-Creme. Die klinische Studie bei Atopikern zeigte eine signifikante Abnahme des Teil-SCORAD und des Erythems im Testareal. Es wurden keine Unverträglichkeitsreaktionen beobachtet. PO als 2%ige Zubereitung besitzt entzündungshemmende Eigenschaften und ist wirksam und gut verträglich auf atopischer Haut. © 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Loess and Loess-like Sediments on the Tibetan Plateau: New Results and Findings

NASA Astrophysics Data System (ADS)

Lehmkuhl, F.

2014-12-01

Aeolian, loess-like sediments distributed as mantles of silt covering the bedrock and debris are widespread depositions in the Qilain Shan and on the Tibetan Plateau (Lehmkuhl 1997). Up to now little is known about the timing and distribution of these late Quaternary sediments originated from far and local transported aeolian dust and sand. They represent valuable archives about environmental change during the late Quaternary. In addition, this fine material is important for growth of the vegetation cover and for water storage and nomadic life. Radiocarbon and luminescence dating provide information concerning their timing to the end of the last glacial cycle and especially to the Holocene, as some of them include loess-paleosol sequences. In addition, valuable information on paleoenvironmental conditions was acquired by grain-size distribution and geochemical analyses (e.g. Nottebaum et al. 2014, Lehmkuhl et. al. 2014). This contribution mainly focuses on the Qilian Shan, the northeastern and southern Tibetan Plateau. Lehmkuhl F. (1997). The spatial distribution of loess and loess-like sediments in the mountain areas of Central and High Asia, Zeitschrift für Geomorphologie, N.F., Suppl.-Bd. 111, 97-116. Lehmkuhl F., Schulte P., Zhao H., Hülle D., Protze J., Stauch G. (2014). Timing and spatial distribution of loess and loess-like sediments in the mountain areas of the northeastern Tibetan Plateau, Catena 117, 22-33. Nottebaum V., Lehmkuhl F., Stauch G., Hartmann K., Wünnemann B, Schimpf S, Lu H. (2014): Regional grain size variations in aeolian sediments along the transition between Tibetan highlands and northwestern Chinese deserts: The influence of geomorphological settings on aeolian transport pathways, Earth Surface Processes and Landforms, in press. DOI: 10.1002/esp.3590

Three-dimensional instabilities of pantographic sheets with parabolic lattices: numerical investigations

NASA Astrophysics Data System (ADS)

Scerrato, Daria; Giorgio, Ivan; Rizzi, Nicola Luigi

2016-06-01

In this paper, we determine numerically a large class of equilibrium configurations of an elastic two-dimensional continuous pantographic sheet in three-dimensional deformation consisting of two families of fibers which are parabolic prior to deformation. The fibers are assumed (1) to be continuously distributed over the sample, (2) to be endowed of bending and torsional stiffnesses, and (3) tied together at their points of intersection to avoid relative slipping by means of internal (elastic) pivots. This last condition characterizes the system as a pantographic lattice (Alibert and Della Corte in Zeitschrift für angewandte Mathematik und Physik 66(5):2855-2870, 2015; Alibert et al. in Math Mech Solids 8(1):51-73, 2003; dell'Isola et al. in Int J Non-Linear Mech 80:200-208, 2016; Int J Solids Struct 81:1-12, 2016). The model that we employ here, developed by Steigmann and dell'Isola (Acta Mech Sin 31(3):373-382, 2015) and first investigated in Giorgio et al. (Comptes rendus Mecanique 2016, doi: 10.1016/j.crme.2016.02.009), is applicable to fiber lattices in which three-dimensional bending, twisting, and stretching are significant as well as a resistance to shear distortion, i.e., to the angle change between the fibers. Some relevant numerical examples are exhibited in order to highlight the main features of the model adopted: In particular, buckling and post-buckling behaviors of pantographic parabolic lattices are investigated. The fabric of the metamaterial presented in this paper has been conceived to resist more effectively in the extensional bias tests by storing more elastic bending energy and less energy in the deformation of elastic pivots: A comparison with a fabric constituted by beams which are straight in the reference configuration shows that the proposed concept is promising.

The Dynamics of Chemical Reactions: Atomistic Visualizations of Organic Reactions, and Homage to van 't Hoff.

PubMed

Yang, Zhongyue; Houk, K N

2018-03-15

Jacobus Henricus van 't Hoff was the first Nobel Laureate in Chemistry. He pioneered in the study of chemical dynamics, which referred at that time to chemical kinetics and thermodynamics. The term has evolved in modern times to refer to the exploration of chemical transformations in a time-resolved fashion. Chemical dynamics has been driven by the development of molecular dynamics trajectory simulations, which provide atomic visualization of chemical processes and illuminate how dynamic effects influence chemical reactivity and selectivity. In homage to the legend of van 't Hoff, we review the development of the chemical dynamics of organic reactions, our area of research. We then discuss our trajectory simulations of pericyclic reactions, and our development of dynamic criteria for concerted and stepwise reaction mechanisms. We also describe a method that we call environment-perturbed transition state sampling, which enables trajectory simulations in condensed-media using quantum mechanics and molecular mechanics (QM/MM). We apply the method to reactions in solvent and in enzyme. Jacobus Henricus van 't Hoff (1852, Rotterdam-1911, Berlin) received the Nobel Prize for Chemistry in 1901 "in recognition of the extraordinary services he has rendered by the discovery of the laws of chemical dynamics and osmotic pressure in solutions". van 't Hoff was born the Netherlands, and earned his doctorate in Utrecht in 1874. In 1896 he moved to Berlin, where he was offered a position with more research and less teaching. van 't Hoff is considered one of the founders of physical chemistry. A key step in establishing this new field was the start of Zeitschrift für Physikalische Chemie in 1887. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

King post truss as a motif for internal structure of (meta)material with controlled elastic properties

NASA Astrophysics Data System (ADS)

Turco, Emilio; Giorgio, Ivan; Misra, Anil; dell'Isola, Francesco

2017-10-01

One of the most interesting challenges in the modern theory of materials consists in the determination of those microstructures which produce, at the macro-level, a class of metamaterials whose elastic range is many orders of magnitude wider than the one exhibited by `standard' materials. In dell'Isola et al. (2015 Zeitschrift für angewandte Mathematik und Physik 66, 3473-3498. (doi:10.1007/s00033-015-0556-4)), it was proved that, with a pantographic microstructure constituted by `long' micro-beams it is possible to obtain metamaterials whose elastic range spans up to an elongation exceeding 30%. In this paper, we demonstrate that the same behaviour can be obtained by means of an internal microstructure based on a king post motif. This solution shows many advantages: it involves only microbeams; all constituting beams are undergoing only extension or compression; all internal constraints are terminal pivots. While the elastic deformation energy can be determined as easily as in the case of long-beam microstructure, the proposed design seems to have obvious remarkable advantages: it seems to be more damage resistant and therefore to be able to have a wider elastic range; it can be realized with the same three-dimensional printing technology; it seems to be less subject to compression buckling. The analysis which we present here includes: (i) the determination of Hencky-type discrete models for king post trusses, (ii) the application of an effective integration scheme to a class of relevant deformation tests for the proposed metamaterial and (iii) the numerical determination of an equivalent second gradient continuum model. The numerical tools which we have developed and which are presented here can be readily used to develop an extensive measurement campaign for the proposed metamaterial.

Microwave Spectrum of Hydrogen Bonded HEXAFLUOROISOPROPANOL•••WATER Complex

NASA Astrophysics Data System (ADS)

Shahi, Abhishek; Arunan, Elangannan

2014-06-01

Stabilizing α-helical structure of protein and dissolving a hard to dissolve polymer, polythene terphthalete, are some of the unique properties of the organic solvent Hexafluoroisopropanol (HFIP). After determining the complete microwave spectrum of HFIP monomer, we have recorded the spectrum of HFIP***H_2O complex. Ab initio calculations were used to optimize three different possible structures. The global minimum, structure 1, had HFIP as proton donor. Another promising structure, Structure 2, has been obtained from a molecular dynamic study. A total of 46 observed lines have been fitted well for obtaining the rotational and distortion constants within experimental uncertainty. The observed rotational constants are A = 1134.53898(77) MHz, B = 989.67594(44) MHz and C = 705.26602(20) MHz. Interestingly, the rotational constants of structure 1, structure 2 and experiments were very close. Experimentally observed distortion constants were close to structure 1. b-type transitions were stronger than c-type which is also consistent with the calculated dipole moment components of structure 1. Calculations predict a non-zero a-dipole moment but experimentally a-type transitions were absent. Microwave spectra of two of the deuterium isotopologues of this complex i.e. HFIP***D_2O (30 transitions) and HFIP***HOD (33 transitions) have been also observed. Search for other isotopologues are in progress. To characterize the nature of hydrogen bonding, Atoms in Molecules and Natural Bond Orbital theoretical analysis have been done. Experimental structure and these theoretical analyses indicate that the hydrogen bonding in HFIP***H_2O complex is stronger than that in water dimer. A. Shahi and E. Arunan, Talk number RK16, 68th International Symposium on Molecular Spectroscopy 2013, Ohio, USA. Yamaguchi, T.; Imura, S.; Kai, T.; Yoshida, K. Zeitschrift für Naturforsch. A 2013, 68a, 145.

Electric Properties of Obsidian: Evidence for Positive Hole Charge Carriers

NASA Astrophysics Data System (ADS)

Nordvik, R.; Freund, F. T.

2012-12-01

The blackness of obsidian is due to the presence of oxygen anions in the valence state 1-, creating broad energy levels at the upper edge of the valence band, which absorb visible light over a wide spectral range. These energy states are associated with defect electrons in the oxygen anion sublattice, well-known from "smoky quartz", where Al substituting for Si captures a defect electron in the oxygen anion sublattice for charge compensation [1]. Such defect electrons, also known as positive holes, are responsible for the increase in electrical conductivity in igneous rocks when uniaxial stresses are applied, causing the break-up of pre-existing peroxy defects, Si-OO-Si [2]. Peroxy defects in obsidian cannot be so easily activated by mechanical stress because the glassy matrix will break before sufficiently high stress levels can be reached. If peroxy defects do exist, however, they can be studied by activating them thermally [3]. We describe experiments with rectangular slabs of obsidian with Au electrodes at both ends. Upon heating one end, we observe (i) a thermopotential and (ii) a thermocurrent developing at distinct temperatures around 250°C and 450°C, marking the 2-step break-up of peroxy bonds. [1] Schnadt, R., and Schneider, J.: The electronic structure of the trapped-hole center in smoky quartz, Zeitschrift Physik B Condensed Matter 11, 19-42, 1970. [2] Freund, F. T., Takeuchi, A., and Lau, B. W.: Electric currents streaming out of stressed igneous rocks - A step towards understanding pre-earthquake low frequency EM emissions, Physics and Chemistry of the Earth, 31, 389-396, 2006. [3] Freund, F., and Masuda, M. M.: Highly mobile oxygen hole-type charge carriers in fused silica, Journal Material Research, 8, 1619-1622, 1991.

Impact of High-Intensity-NIV on the heart in stable COPD: a randomised cross-over pilot study.

PubMed

Duiverman, Marieke Leontine; Maagh, Petra; Magnet, Friederike Sophie; Schmoor, Claudia; Arellano-Maric, Maria Paola; Meissner, Axel; Storre, Jan Hendrik; Wijkstra, Peter Jan; Windisch, Wolfram; Callegari, Jens

2017-05-02

Although high-intensity non-invasive ventilation has been shown to improve outcomes in stable COPD, it may adversely affect cardiac performance. Therefore, the aims of the present pilot study were to compare cardiac and pulmonary effects of 6 weeks of low-intensity non-invasive ventilation and 6 weeks of high-intensity non-invasive ventilation in stable COPD patients. In a randomised crossover pilot feasibility study, the change in cardiac output after 6 weeks of each NIV mode compared to baseline was assessed with echocardiography in 14 severe stable COPD patients. Furthermore, CO during NIV, gas exchange, lung function, and health-related quality of life were investigated. Three patients dropped out: two deteriorated on low-intensity non-invasive ventilation, and one presented with decompensated heart failure while on high-intensity non-invasive ventilation. Eleven patients were included in the analysis. In general, cardiac output and NTproBNP did not change, although individual effects were noticed, depending on the pressures applied and/or the co-existence of heart failure. High-intensity non-invasive ventilation tended to be more effective in improving gas exchange, but both modes improved lung function and the health-related quality of life. Long-term non-invasive ventilation with adequate pressure to improve gas exchange and health-related quality of life did not have an overall adverse effect on cardiac performance. Nevertheless, in patients with pre-existing heart failure, the application of very high inspiratory pressures might reduce cardiac output. The trial was registered in the Deutsches Register Klinischer Studien (DRKS-ID: DRKS00007977 ).

Effects of OK-432 (picibanil) on the estrogen receptors of MCF-7 cells and potentiation of antiproliferative effects of tamoxifen in combination with OK-432.

PubMed

Aoyagi, H; Iino, Y; Takeo, T; Horii, Y; Morishita, Y; Horiuchi, R

1997-01-01

OK-432 (picibanil), a streptococcal preparation, has a strong biological response modifier (BRM) function and is expected to produce clinical improvement and prolongation of survival in treated cancer patients in Japan. We were interested in whether OK-432 augments estrogen receptor (ER) levels in breast cancer. To investigate the effect of the BRMs on cellular growth and the characteristics of ER and progesterone receptors (PgR) in the human breast cancer cell line MCF-7, we used OK-432, Krestin (PSK), a protein-bound polysaccharide extracted from Coriolus versicolor, and lentinan, a fungal branched (1...3)-beta-D-glycan. OK432 and PSK dose dependently inhibited DNA synthesis of MCF-7 cells, and the 50% inhibitory concentrations of OK-432 and PSK were 1.2 KE (klinische Einheit, clinical unit)/ml and 200 micrograms/ml, respectively. Lentinan showed no direct anticancer effect in vitro. We found that OK-432 induced a 2-fold increase in ER levels in MCF-7 cells at 0.005 KE/ml, but not in PgR. Lentinan and low-dose PSK did not change ER or PgR levels, but high-dose PSK decreased ER and PgR. We also studied the combined effect of OK-432 and antiestrogens, tamoxifen (TAM) and DP-TAT-59. The combined treatment with OK-432 and TAM showed an additive inhibitory effect on MCF-7 cells. These results suggest that OK-432 may augment the therapeutic effect of TAM in breast cancer.

Immediate versus delayed loading of strategic mini dental implants for the stabilization of partial removable dental prostheses: a patient cluster randomized, parallel-group 3-year trial.

PubMed

Mundt, Torsten; Al Jaghsi, Ahmad; Schwahn, Bernd; Hilgert, Janina; Lucas, Christian; Biffar, Reiner; Schwahn, Christian; Heinemann, Friedhelm

2016-07-30

Acceptable short-term survival rates (>90 %) of mini-implants (diameter < 3.0 mm) are only documented for mandibular overdentures. Sound data for mini-implants as strategic abutments for a better retention of partial removable dental prosthesis (PRDP) are not available. The purpose of this study is to test the hypothesis that immediately loaded mini-implants show more bone loss and less success than strategic mini-implants with delayed loading. In this four-center (one university hospital, three dental practices in Germany), parallel-group, controlled clinical trial, which is cluster randomized on patient level, a total of 80 partially edentulous patients with unfavourable number and distribution of remaining abutment teeth in at least one jaw will receive supplementary min-implants to stabilize their PRDP. The mini-implant are either immediately loaded after implant placement (test group) or delayed after four months (control group). Follow-up of the patients will be performed for 36 months. The primary outcome is the radiographic bone level changes at implants. The secondary outcome is the implant success as a composite variable. Tertiary outcomes include clinical, subjective (quality of life, satisfaction, chewing ability) and dental or technical complications. Strategic implants under an existing PRDP are only documented for standard-diameter implants. Mini-implants could be a minimal invasive and low cost solution for this treatment modality. The trial is registered at Deutsches Register Klinischer Studien (German register of clinical trials) under DRKS-ID: DRKS00007589 ( www.germanctr.de ) on January 13(th), 2015.

Reworked Middle Jurassic sandstones as a marker for Upper Cretaceous basin inversion in Central Europe—a case study for the U-Pb detrital zircon record of the Upper Cretaceous Schmilka section and their implication for the sedimentary cover of the Lausitz Block (Saxony, Germany)

NASA Astrophysics Data System (ADS)

Hofmann, Mandy; Voigt, Thomas; Bittner, Lucas; Gärtner, Andreas; Zieger, Johannes; Linnemann, Ulf

2018-04-01

The Saxonian-Bohemian Cretaceous Basin (Elbsandsteingebirge, E Germany and Czech Republic, Elbtal Group) comprises Upper Cretaceous sedimentary rocks from Upper Cenomanian to Santonian age. These sandstones were deposited in a narrow strait of the sea linking the northern Boreal shelf to the southern Tethyan areas. They were situated between the West Sudetic Island in the north and the Mid-European Island in the south. As known by former studies (e.g. Tröger, Geologie 6/7:717-730, 1964; Tröger, Geologie von Sachsen, Schweizerbart, 311-358, 2008; Voigt and Tröger, Proceedings of the 4th International Cretaceous Symposium, 275-290, 1996; Voigt, Dissertation, TU Bergakademie Freiberg, 1-130, 1995; Voigt, Zeitschrift der geologischen Wissenschaften 37(1-2): 15-39, 2009; Wilmsen et al., Freiberger Forschungshefte C540: 27-45, 2011) the main sedimentary input came from the north (Lausitz Block, southern West-Sudetic Island). A section of Turonian to Coniacian sandstones was sampled in the Elbsandsteingebirge near Schmilka (Elbtal Group, Saxony, Germany). The samples were analysed for their U-Pb age record of detrital zircon using LA-ICP-MS techniques. The results show main age clusters typical for the Bohemian Massif (local material) and are interpreted to reflect the erosion of uniform quartz-dominated sediments and basement rocks. Surprisingly, these rocks lack an expected Upper Proterozoic to Lower Palaeozoic age peak, which would be typical for the basement of the adjacent Lausitz Block (c. 540-c. 560 Ma). Therefore, the Lausitz Block basement must have been covered by younger sediments that acted as source rocks during deposition of the Elbtal Group. The sandstones of the Elbe valley (Elbtal Group, Schmilka section) represent the re-deposited sedimentary cover of the Lausitz Block in inverse order. This cover comprised Permian, Triassic, Jurassic and Lower Cretaceous deposits, which are eroded already today and cannot be investigated. Within the samples of the Elbtal Group (Schmilka section), the zircon age patterns change significantly towards the Lower Coniacian (topmost sample of the analysed section), where a major input of Meso- and Paleoproterozoic grains was obtained. Comparable ages are generally scarce in the working area. To have a reference for the detrital zircon age spectra of Triassic and Jurassic sediments of the area, two Upper Triassic und two Middle Jurassic clastic sediments of Germany were analysed. Surprisingly, the two Middle Jurassic (Dogger) sandstones from Bavaria and Lower Saxony showed similar detrital zircon age compositions as the Coniacian sediments on top of the Schmilka section (Elbe valley, Elbtal Group). In contrast, the two Upper Triassic sediments could be excluded as possible source rocks for the Upper Cretaceous sandstones of the Elbe valley (Schmilka section, Elbtal Group). The Meso- and Paleoproterozoic zircon age populations in the uppermost sandstone sample of the Schmilka section are assumed to originate from recycled Jurassic (Dogger) sandstones, resting on the Lausitz Block. These Middle Jurassic deposits were strongly influenced by a sedimentary input from the Scandinavian region (southern Baltica and North Sea Dome). The Turonian sandstones of the Schmilka section (samples below the topmost Coniacian sample) are interpreted to represent re-deposited Lower Cretaceous sediments resting on the Lausitz Block. A proposed synsedimentary uplift of about 5 km during the Upper Cretaceous along the Lausitz Fold (Lange et al., Zeitschrift der Deutschen Gesellschaft für Geowissenschaften 159(1):123-132, 2008) would have caused erosion of the pre-existing sedimentary cover of the Lausitz Block followed by inverse accumulation of the detritus into the Cretaceous Basin (Elbe valley, Elbtal Group). The Permian and Triassic cover units of the Lausitz Block were not exposed during the Upper Cretaceous, but are assumed to have contributed to younger (post-Coniacian) sediments of the Elbtal Group, which were eroded during uppermost Cretaceous and lower Paleogene. Based on this study, the detrital zircon record of the Jurassic Dogger sandstones of Germany can be seen as "marker ages" for the European Cretaceous Basin inversion. This paper presents the first results of a case study with further investigations in other areas of Europe to follow.

Detection of Pneumonia Associated Pathogens Using a Prototype Multiplexed Pneumonia Test in Hospitalized Patients with Severe Pneumonia

PubMed Central

Schulte, Berit; Eickmeyer, Holm; Heininger, Alexandra; Juretzek, Stephanie; Karrasch, Matthias; Denis, Olivier; Roisin, Sandrine; Pletz, Mathias W.; Klein, Matthias; Barth, Sandra; Lüdke, Gerd H.; Thews, Anne; Torres, Antoni; Cillóniz, Catia; Straube, Eberhard; Autenrieth, Ingo B.; Keller, Peter M.

2014-01-01

Severe pneumonia remains an important cause of morbidity and mortality. Polymerase chain reaction (PCR) has been shown to be more sensitive than current standard microbiological methods – particularly in patients with prior antibiotic treatment – and therefore, may improve the accuracy of microbiological diagnosis for hospitalized patients with pneumonia. Conventional detection techniques and multiplex PCR for 14 typical bacterial pneumonia-associated pathogens were performed on respiratory samples collected from adult hospitalized patients enrolled in a prospective multi-center study. Patients were enrolled from March until September 2012. A total of 739 fresh, native samples were eligible for analysis, of which 75 were sputa, 421 aspirates, and 234 bronchial lavages. 276 pathogens were detected by microbiology for which a valid PCR result was generated (positive or negative detection result by Curetis prototype system). Among these, 120 were identified by the prototype assay, 50 pathogens were not detected. Overall performance of the prototype for pathogen identification was 70.6% sensitivity (95% confidence interval (CI) lower bound: 63.3%, upper bound: 76.9%) and 95.2% specificity (95% CI lower bound: 94.6%, upper bound: 95.7%). Based on the study results, device cut-off settings were adjusted for future series production. The overall performance with the settings of the CE series production devices was 78.7% sensitivity (95% CI lower bound: 72.1%) and 96.6% specificity (95% CI lower bound: 96.1%). Time to result was 5.2 hours (median) for the prototype test and 43.5 h for standard-of-care. The Pneumonia Application provides a rapid and moderately sensitive assay for the detection of pneumonia-causing pathogens with minimal hands-on time. Trial Registration Deutsches Register Klinischer Studien (DRKS) DRKS00005684 PMID:25397673

Utility of nociceptive flexion reflex threshold and bispectral index to predict movement responses under propofol anaesthesia.

PubMed

Jakuscheit, Axel; Posch, Matthias J; Gkaitatzis, Stefanos; Neumark, Lisa; Hackbarth, Mark; Schneider, Martin; Lichtner, Gregor; Baars, Jan H; von Dincklage, Falk

2017-06-01

The nociceptive flexion reflex threshold (NFRT) is a promising tool to monitor analgesia during general anaesthesia. Clinical studies have shown that the NFRT allows to predict movement responses to painful stimuli under a combined anaesthetic regime of sedative and opioid agents. Experimental studies indicated that the NFRT is also able to predict such movement responses under an exclusively sedative regime like propofol mono-anaesthesia. Therefore, we performed this study to investigate the ability of the NFRT to predict movement responses to painful stimuli in patients during a clinical propofol mono-anaesthesia. We investigated 140 cardiac surgery patients during their postoperative phase under propofol mono-anaesthesia. NFRT and bispectral index (BIS) were determined in each patient right before endotracheal suctioning or painful electrical test stimulation. Prediction probabilities were calculated to quantify how accurate each measure is able to predict movement responses to the stimuli. The 124 patients included in the analysis received a median propofol dosage of 3.2 (2.5-3.9) [median (IQR)] mg/kg/h. The included patients showed 287 movement responses after a total of 725 investigated stimuli. The prediction probabilities for positive movement responses were 0.63 (95%CI: 0.59-0.67) for the NFRT and 0.69 (95%CI: 0.65-0.73) for the BIS. The NFRT allows the prediction of movement responses under propofol mono-anaesthesia, which confirms its utility as a monitor to predict movement responses under general anaesthesia. The BIS allows an even more accurate prediction, although it does not reflect the physiological structures of movement suppression, but correlates closely with the dose of propofol. German clinical trial register (DRKS00003062, Deutsches Register Klinischer Studien).

OpenDA Open Source Generic Data Assimilation Environment and its Application in Process Models

NASA Astrophysics Data System (ADS)

El Serafy, Ghada; Verlaan, Martin; Hummel, Stef; Weerts, Albrecht; Dhondia, Juzer

2010-05-01

Data Assimilation techniques are essential elements in state-of-the-art development of models and their optimization with data in the field of groundwater, surface water and soil systems. They are essential tools in calibration of complex modelling systems and improvement of model forecasts. The OpenDA is a new and generic open source data assimilation environment for application to a choice of physical process models, applied to case dependent domains. OpenDA was introduced recently when the developers of Costa, an open-source TU Delft project [http://www.costapse.org; Van Velzen and Verlaan; 2007] and those of the DATools from the former WL|Delft Hydraulics [El Serafy et al 2007; Weerts et al. 2009] decided to join forces. OpenDA makes use of a set of interfaces that describe the interaction between models, observations and data assimilation algorithms. It focuses on flexible applications in portable systems for modelling geophysical processes. It provides a generic interfacing protocol that allows combination of the implemented data assimilation techniques with, in principle, any time-stepping model duscribing a process(atmospheric processes, 3D circulation, 2D water level, sea surface temperature, soil systems, groundwater etc.). Presently, OpenDA features filtering techniques and calibration techniques. The presentation will give an overview of the OpenDA and the results of some of its practical applications. Application of data assimilation in portable operational forecasting systems—the DATools assimilation environment, El Serafy G.Y., H. Gerritsen, S. Hummel, A. H. Weerts, A.E. Mynett and M. Tanaka (2007), Journal of Ocean Dynamics, DOI 10.1007/s10236-007-0124-3, pp.485-499. COSTA a problem solving environment for data assimilation applied for hydrodynamical modelling, Van Velzen and Verlaan (2007), Meteorologische Zeitschrift, Volume 16, Number 6, December 2007 , pp. 777-793(17). Application of generic data assimilation tools (DATools) for flood forecasting purposes, A.H. Weerts, G.Y.H. El Serafy, S. Hummel, J. Dhondia, and H. Gerritsen (2009), accepted by Geoscience & Computers.

On the surface roughness of a braidplain in an Alpine proglacial area

NASA Astrophysics Data System (ADS)

Baewert, H.; Morche, D.; Culha, C.

2014-12-01

Surface roughness is a crucial parameter of studies concerning (paleo) flood peak discharge estimation and related factors (cf. stream power). Usually, the analysis requires preliminary knowledge of grain size distribution of the study site. However, in some cases this is impractical, especially when investigating large areas, or even impossible due to inaccessibility. In addition, the particles in the channel are usually hidden by other particles or incorporated into finer sediment. Therefore, removing particles from the channel bottom is not suitable, because it falsifies the results. Here, the application of noninvasive terrestrial laser scanning (TLS) offers new possibilities. The indirect recording of the surface leads to a significant reduction of the workload. Furthermore, form roughness and burial/imbrication are taken into account. However, there are some disadvantages in using TLS. The resolution of the TLS data is a limiting factor when defining surface roughness, because coarseness at finer detail will not be captured at lower resolution (Baewert et al. 2014). There are numerous other factors, which may alter the results. We would like to further understand how the noise associated with TLS data alters the outcome and whether the interpolation method has an influence. This study focuses on the latter two issues. For this purpose, a braidplain in the forefield of the glacier Gepatschferner in Austria was surveyed using a terrestrial laser scanner. The images were taken from different angles and with different resolutions. Subsequently, the outliers are removed from the point cloud in order to investigate the influence of the noise. Thinning the point cloud is another method used to understand the effects of the point density. References Baewert, H., Bimböse, M., Bryk, A., Rascher, E., Schmidt, K.-H. & Morche, D. (2014): Roughness determination of coarse grained alpine river bed surfaces using Terrestrial Laser Scanning data. - Zeitschrift für Geomorphologie N.F. 58(1): 81-95. Doi: 10.1127/0372-8854/2013/S-00127 .

Interjections in the performance of Jane Austen's Pride and prejudice.

PubMed

O'Connell, Daniel C; Kowal, Sabine

2010-08-01

Three data sets of primary and secondary interjections were compared: (1) the original interjections written into the text of Jane Austen's (1813/1994) novel Pride and prejudice; (2) the interjections read aloud in commercial recordings by six professional readers of the entire text of the novel; (3) the interjections spoken by actresses and actors in the film production (Birtwistle and Langton in Pride and prejudice [TV Mini-series]. London: BBC TV, 1995) whose script, despite modest selectiveness, adheres most closely of all film versions to Austen's original text. Overall, the respective frequencies of occurrence of interjections were 136 < 141 < 398. Of the 136 interjections in Austen's printed text, 96% were attributable to women's roles, particularly Elizabeth Bennet and her mother. The second of these figures (141) is an average across all six readers. Hence, readers added a very modest number of interjections. But the actresses and actors added a large number of interjections. The dramatic oral expressiveness of the film performance is largely carried by and reflected in the actresses' and to a lesser extent in the actors' use of these primary interjections. These findings can well be related to Nübling's (Zeitschrift für Semiotik 26:11-45, 2004, Duden: Die Grammatik (pp 573-640). Mannheim: Dudenverlag, 2005) hypothesis of a spectrum of interjectional expressivity. But Ameka's (J Pragmat 18:101-118, 1992) linguistic hypothesis that pauses will both precede and follow interjections was once again found to be empirically groundless. A large percentage (96%) of the interjections in the film performance served the function of initializing various units of discourse, either after a pause before articulatory phrases, or before a sentence and/or turn. Both the emotional and initiating functions of interjections are characteristic of conceptual and medial orality rather than of conceptual and medial literacy. Accordingly, their usage throws further light on a theory of spontaneous spoken discourse.

A storm severity index based on return levels of wind speeds

NASA Astrophysics Data System (ADS)

Becker, Nico; Nissen, Katrin M.; Ulbrich, Uwe

2015-04-01

European windstorms related to extra-tropical cyclones cause considerable damages to infrastructure during the winter season. Leckebusch et al. (2008) introduced a storm severity index (SSI) based on the exceedances of the local 98th percentile of wind speeds. The SSI is based on the assumption that (insured) damage usually occurs within the upper 2%-quantile of the local wind speed distribution (i.e. if the 98th percentile is exceeded). However, critical infrastructure, for example related to the power network or the transportation system, is usually designed to withstand wind speeds reaching the local 50-year return level, which is much higher than the 98th percentile. The aim of this work is to use the 50-year return level to develop a modified SSI, which takes into account only extreme wind speeds relevant to critical infrastructure. As a first step we use the block maxima approach to estimate the spatial distribution of return levels by fitting the generalized extreme value (GEV) distribution to the wind speeds retrieved from different reanalysis products. We show that the spatial distributions of the 50-year return levels derived from different reanalyses agree well within large parts of Europe. The differences between the reanalyses are largely within the range of the uncertainty intervals of the estimated return levels. As a second step the exceedances of the 50-year return level are evaluated and compared to the exceedances of the 98th percentiles for different extreme European windstorms. The areas where the wind speeds exceed the 50-year return level in the reanalysis data do largely agree with the areas where the largest damages were reported, e.g. France in the case of "Lothar" and "Martin" and Central Europe in the case of "Kyrill". Leckebusch, G. C., Renggli, D., & Ulbrich, U. (2008). Development and application of an objective storm severity measure for the Northeast Atlantic region. Meteorologische Zeitschrift, 17(5), 575-587.

How to Calculate Spin-Spin Coupling and Spin-Rotation Coupling Strengths and Their Uncertainties from Spectroscopic Data: Application to the c(1^3Σ_g^+) State of Diatomic Lithium

NASA Astrophysics Data System (ADS)

Dattani, Nikesh S.; Li, Xuan

2013-06-01

Recent high-resolution (± 0.00002 cm^{-1}) photo-association spectroscopy (PAS) data of seven previously unexplored vibrational levels of the 1^3Σ_g^+ state of Li_2 have allowed for the first ever experimental determination of the spin-spin (λ_v) and spin-rotation (γ_v) coupling constants in a diatomic lithium system. For triplet states of diatomic molecules such as the 1^3Σ_g^+ state of Li_2, the three spin-spin/spin-rotation resolved energies associated with a ro-vibrational state |v,N> were expressed explicity in terms of B_v, λ_v, and γ_v in 1929 by Kramer's first-order formulas and then in 1937 by Schlapp's more refined formulas. Given spectroscopic data, while it has never been difficult to extract λ_v and γ_v from Schlapp's formulas, it has been a challenge to reliably predict how accurate these extracted values are. This is for two reasons: (1) the lack of a rigorous method to estimate the uncertainty in B_v, (2) the non-linearity of Schlapp's coupled equations has meant that traditionally they have had to be solved numerically by Newton iterations which makes error propagation difficult. The former challenge has been this year solved by Le Roy with a modification of Hutson's perturbation theory of, and the latter problem has now been solved by symbolic computing software that solves Schlapp's coupled non-linear equations analytically for the first time since their introduction in 1937. M. Semczuk, X. Li, W. Gunton, M. Haw, N. Dattani, J. Witz, A. Mills, D. Jones, K. Madison, Physical Review A {87}, XX (2013) H. Kramers, Zeitschrift fur Physik {53}, 422 (1929) R. Schlapp, Physical Review {51}, 342 (1937) J. Hutson, J. Phys. B, {14}, 851 (1981)

Discrete is it enough? The revival of Piola-Hencky keynotes to analyze three-dimensional Elastica

NASA Astrophysics Data System (ADS)

Turco, Emilio

2018-04-01

Complex problems such as those concerning the mechanics of materials can be confronted only by considering numerical simulations. Analytical methods are useful to build guidelines or reference solutions but, for general cases of technical interest, they have to be solved numerically, especially in the case of large displacements and deformations. Probably continuous models arose for producing inspiring examples and stemmed from homogenization techniques. These techniques allowed for the solution of some paradigmatic examples but, in general, always require a discretization method for solving problems dictated by the applications. Therefore, and also by taking into account that computing powers are nowadays more largely available and cheap, the question arises: why not using directly a discrete model for 3D beams? In other words, it could be interesting to formulate a discrete model without using an intermediate continuum one, as this last, at the end, has to be discretized in any case. These simple considerations immediately evoke some very basic models developed many years ago when the computing powers were practically inexistent but the problem of finding simple solutions to beam deformation problem was already an emerging one. Actually, in recent years, the keynotes of Hencky and Piola attracted a renewed attention [see, one for all, the work (Turco et al. in Zeitschrift für Angewandte Mathematik und Physik 67(4):1-28, 2016)]: generalizing their results, in the present paper, a novel directly discrete three-dimensional beam model is presented and discussed, in the framework of geometrically nonlinear analysis. Using a stepwise algorithm based essentially on Newton's method to compute the extrapolations and on the Riks' arc-length method to perform the corrections, we could obtain some numerical simulations showing the computational effectiveness of presented model: Indeed, it presents a convenient balance between accuracy and computational cost.

Replication of endometriosis-associated single-nucleotide polymorphisms from genome-wide association studies in a Caucasian population.

PubMed

Sundqvist, J; Xu, H; Vodolazkaia, A; Fassbender, A; Kyama, C; Bokor, A; Gemzell-Danielsson, K; D'Hooghe, T M; Falconer, H

2013-03-01

Is it possible to replicate the previously identified genetic association of four single-nucleotide polymorphisms (SNPs), rs12700667, rs7798431, rs1250248 and rs7521902, with endometriosis in a Caucasian population? A borderline association was observed for rs1250248 and endometriosis (P = 0.049). However, we could not replicate the other previously identified endometriosis-associated SNPs (rs12700667, rs7798431 and rs7521902) in the same population. Endometriosis is considered a complex disease, influenced by several genetic and environmental factors, as well as interactions between them. Previous studies have found genetic associations with endometriosis for SNPs at the 7p15 and 2q35 loci in a Caucasian population. Allele frequencies of SNPs were investigated in patients with endometriosis and controls. Blood samples and peritoneal biopsies were taken from a Caucasian female population consisting of 1129 patients with endometriosis and 831 controls. DNA was extracted for genotyping. The study was performed at a University hospital and research laboratories. A weak association with endometriosis (all stages) was observed for rs1250248 (P = 0.049). No significant associations were observed for the SNPs rs12700667, rs7798431 and rs7521902. A non-significant trend towards the association of rs1250248 with moderate/severe endometriosis was observed (odds ratio 1.18, 95% confidence interval 0.97-1.44). The inability to confirm all previous findings may result from differences between populations and type II errors. Our result demonstrates the difficulty of identifying common genetic variants in complex diseases. This study was supported by grants from the Karolinska Institutet and Stockholm City County/Karolinska Institutet (ALF), Stockholm, Sweden, Swedish Medical Research Council (K2007-54X-14212-06-3, K2010-54X-14212-09-3), Stockholm, Sweden, Leuven University Research Council (Onderzoeksraad KU Leuven), the Leuven University Hospitals Clinical Research Foundation (Klinisch onderzoeksfonds) and by the National Scientific Foundation (Fonds voor Wetenschappelijk Onderzoek, FWO). The authors have no conflict of interest.

Evaluation of OK-432 Injection Therapy as Possible Primary Treatment of Intraoral Ranula.

PubMed

Kono, Michihide; Satomi, Takafumi; Abukawa, Harutsugi; Hasegawa, On; Watanabe, Masato; Chikazu, Daichi

2017-02-01

A ranula is a pseudocyst caused by mucous extravasation from the sublingual gland. Recently, a sclerosing agent, OK-432 (picibanil), has been reported to be highly effective for treating lymphangioma and cervical cystic lesions. The present study assessed the effectiveness of OK-432 injection therapy for intraoral ranula to clarify whether it can be used as the primary treatment. The present study was a retrospective clinical study of patients with intraoral ranula who received OK-432 injection therapy from 2005 to 2015. The ranula size was measured on computed tomography or magnetic resonance imaging studies. We dissolved 1 Klinische Einheit (KE) unit of OK-432 powder in normal saline equal to the aspiration volume. The primary endpoint was the treatment results. The secondary endpoints were the relation between the treatment results and the lesion length and aspiration volume. A total of 23 patients received OK-432 injection therapy for an intraoral ranula. The mean lesion size was 19.96 mm. The mean aspiration volume was 2.14 mL. The number of injections was 1 to 4 (mean 1.70). The treatment results were complete regression (CR) in 18 (78.2%), partial regression (PR) in 3 (13.0%), and no response (NR) in 2 (8%) patients after the last injection. The overall efficacy rate was 91.2% (21 of 23). No serious complications were observed. The lesion length and aspiration volume of the CR group was 17.38 mm and 1.40 mL, respectively. The lesion length and aspiration volume of the PR/NR group was 29.20 mm and 4.80 mL, respectively. The PR/NR group lesions were significantly larger than the CR group lesions. OK-432 injection therapy for intraoral ranula is safe and effective compared with other surgical therapies. This therapy could potentially become a primary treatment of intraoral ranula. Copyright © 2016 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

Effects of a team-based assessment and intervention on patient safety culture in general practice: an open randomised controlled trial.

PubMed

Hoffmann, B; Müller, V; Rochon, J; Gondan, M; Müller, B; Albay, Z; Weppler, K; Leifermann, M; Mießner, C; Güthlin, C; Parker, D; Hofinger, G; Gerlach, F M

2014-01-01

The measurement of safety culture in healthcare is generally regarded as a first step towards improvement. Based on a self-assessment of safety culture, the Frankfurt Patient Safety Matrix (FraTrix) aims to enable healthcare teams to improve safety culture in their organisations. In this study we assessed the effects of FraTrix on safety culture in general practice. We conducted an open randomised controlled trial in 60 general practices. FraTrix was applied over a period of 9 months during three facilitated team sessions in intervention practices. At baseline and after 12 months, scores were allocated for safety culture as expressed in practice structure and processes (indicators), in safety climate and in patient safety incident reporting. The primary outcome was the indicator error management. During the team sessions, practice teams reflected on their safety culture and decided on about 10 actions per practice to improve it. After 12 months, no significant differences were found between intervention and control groups in terms of error management (competing probability=0.48, 95% CI 0.34 to 0.63, p=0.823), 11 further patient safety culture indicators and safety climate scales. Intervention practices showed better reporting of patient safety incidents, reflected in a higher number of incident reports (mean (SD) 4.85 (4.94) vs 3.10 (5.42), p=0.045) and incident reports of higher quality (scoring 2.27 (1.93) vs 1.49 (1.67), p=0.038) than control practices. Applied as a team-based instrument to assess safety culture, FraTrix did not lead to measurable improvements in error management. Comparable studies with more positive results had less robust study designs. In future research, validated combined methods to measure safety culture will be required. In addition, more attention should be paid to evaluation of process parameters. Implemented actions and incident reporting may be more appropriate target endpoints. German Clinical Trials Register (Deutsches Register Klinischer Studien, DRKS) No. DRKS00000145.

Development and testing of culturally sensitive patient information material for Turkish, Polish, Russian and Italian migrants with depression or chronic low back pain (KULTINFO): study protocol for a double-blind randomized controlled trial.

PubMed

Hölzel, Lars P; Ries, Zivile; Zill, Jördis M; Kriston, Levente; Dirmaier, Jörg; Härter, Martin; Bermejo, Isaac

2014-07-04

Many of the approximately 15 million people with a migration background living in Germany (19% of the population) are inadequately reached by existing healthcare provision. In the literature, the necessity for cultural adaptation of information material for patients with a migration background is often cited as a measure for improving healthcare.In this study, culturally sensitive information material will be developed and evaluated for patients with a migration background and depression or chronic low back pain. In this respect, it will be examined whether culturally sensitive information material is judged as more useful by the patients than standard translated patient information without cultural adaptation. The implementation and evaluation of culturally sensitive patient information material will occur in the framework of a double-blind randomized controlled parallel-group study in four study centres in Germany. Primary care patients with a Turkish, Polish, Russian or Italian migration background with a diagnosis of depressive disorder or chronic low back pain will be included and randomly allocated to the intervention group or the control group. In the intervention group, culturally sensitive patient information will be handed to the patient at the end of the physician consultation, while in the control group, standard translated patient information material will be provided. The patients will be surveyed by means of questionnaires following the consultation as well as after 8 weeks and 6 months. In addition to the primary outcome (subjective usefulness), several patient- and physician-rated secondary outcomes will be considered. The study will provide an empirical answer to the question of whether persons with a migration background perceive culturally sensitive patient information material as more useful than translated information material without cultural adaptation. Deutsches Register Klinischer Studien (DRKS-ID) DRKS00004241 and Universal Trial Number (UTN) U1111-1135-8043.

Observation Impacts for Longer Forecast Lead-Times

NASA Astrophysics Data System (ADS)

Mahajan, R.; Gelaro, R.; Todling, R.

2013-12-01

Observation impact on forecasts evaluated using adjoint-based techniques (e.g. Langland and Baker, 2004) are limited by the validity of the assumptions underlying the forecasting model adjoint. Most applications of this approach have focused on deriving observation impacts on short-range forecasts (e.g. 24-hour) in part to stay well within linearization assumptions. The most widely used measure of observation impact relies on the availability of the analysis for verifying the forecasts. As pointed out by Gelaro et al. (2007), and more recently by Todling (2013), this introduces undesirable correlations in the measure that are likely to affect the resulting assessment of the observing system. Stappers and Barkmeijer (2012) introduced a technique that, in principle, allows extending the validity of tangent linear and corresponding adjoint models to longer lead-times, thereby reducing the correlations in the measures used for observation impact assessments. The methodology provides the means to better represent linearized models by making use of Gaussian quadrature relations to handle various underlying non-linear model trajectories. The formulation is exact for particular bi-linear dynamics; it corresponds to an approximation for general-type nonlinearities and must be tested for large atmospheric models. The present work investigates the approach of Stappers and Barkmeijer (2012)in the context of NASA's Goddard Earth Observing System Version 5 (GEOS-5) atmospheric data assimilation system (ADAS). The goal is to calculate observation impacts in the GEOS-5 ADAS for forecast lead-times of at least 48 hours in order to reduce the potential for undesirable correlations that occur at shorter forecast lead times. References [1]Langland, R. H., and N. L. Baker, 2004: Estimation of observation impact using the NRL atmospheric variational data assimilation adjoint system. Tellus, 56A, 189-201. [2] Gelaro, R., Y. Zhu, and R. M. Errico, 2007: Examination of various-order adjoint-based approximations of observation impact. Meteoroloische Zeitschrift, 16, 685-692. [3]Stappers, R. J. J., and J. Barkmeijer, 2012: Optimal linearization trajectories for tangent linear models. Q. J. R. Meteorol. Soc., 138, 170-184. [4] Todling, R. 2013: Comparing two approaches for assessing observation impact. Mon. Wea. Rev., 141, 1484-1505.

Barchan asymmetry as a proxy for wind conditions on Earth and Mars

NASA Astrophysics Data System (ADS)

Dwyer, Diarmuid; Bourke, Mary

2014-05-01

The absence of weather stations in many remote arid regions on Earth and Mars introduces a difficulty in testing atmospheric circulation models. While several proxies have been recommended for the reconstruction of wind regimes, they remain to be tested in a wide range of terrains. We examine the relationship between instrumented wind data and barchan asymmetric shape in order to ascertain if this dune attribute can be used to reliably infer aspects of a wind regime. The two study areas are located in La Joya, Peru and the Namib Desert, Namibia. Dune observations were made using high resolution satellite images available on Google Earth. The wind data was sourced from Wunderground and the National Peruvian Meteorological Service. Asymmetric barchans are reported to form in bimodal wind regimes (Tsoar, 1984). The barchan dune is oriented parallel to the strong wind regime and is modified by oblique gentler winds. Our analysis of wind data and dune form supports the Tsoar model for barchan asymmetry. Numerical simulations have shown that the duration of winds in bi-directional regimes also influences asymmetry (Parteli, 2014). Our analysis finds good agreement between the model simulations of Parteli et al (2014) and the instrument data for Namibia and Peru. We use our findings on Earth to infer formative wind direction and duration at five sites on Mars. These are the first maps of wind direction and relative duration for Mars. Our findings do not concur with previous estimates of wind direction derived either from the NASA Ames General Circulation Model or dune slipface orientation. We propose that the Parteli et al (2014) approach can be usefully applied to remote areas on Earth and Mars to extract data on relative wind duration and direction. Parteli, E.J.R., Duran, O., Bourke, M.C., Tsoar, H., Poschel, T., Herrmann, H.J., (in press). Origins of barchan dune asymmetry: Insights from numerical simulations. Aeolian Research. Tsoar, H., (1984). The formation of seif dunes from barchans - a discussion. Zeitschrift fur Geomorphologie, 28, 99-103.

Testing particle filters on convective scale dynamics

NASA Astrophysics Data System (ADS)

Haslehner, Mylene; Craig, George. C.; Janjic, Tijana

2014-05-01

Particle filters have been developed in recent years to deal with highly nonlinear dynamics and non Gaussian error statistics that also characterize data assimilation on convective scales. In this work we explore the use of the efficient particle filter (P.v. Leeuwen, 2011) for convective scale data assimilation application. The method is tested in idealized setting, on two stochastic models. The models were designed to reproduce some of the properties of convection, for example the rapid development and decay of convective clouds. The first model is a simple one-dimensional, discrete state birth-death model of clouds (Craig and Würsch, 2012). For this model, the efficient particle filter that includes nudging the variables shows significant improvement compared to Ensemble Kalman Filter and Sequential Importance Resampling (SIR) particle filter. The success of the combination of nudging and resampling, measured as RMS error with respect to the 'true state', is proportional to the nudging intensity. Significantly, even a very weak nudging intensity brings notable improvement over SIR. The second model is a modified version of a stochastic shallow water model (Würsch and Craig 2013), which contains more realistic dynamical characteristics of convective scale phenomena. Using the efficient particle filter and different combination of observations of the three field variables (wind, water 'height' and rain) allows the particle filter to be evaluated in comparison to a regime where only nudging is used. Sensitivity to the properties of the model error covariance is also considered. Finally, criteria are identified under which the efficient particle filter outperforms nudging alone. References: Craig, G. C. and M. Würsch, 2012: The impact of localization and observation averaging for convective-scale data assimilation in a simple stochastic model. Q. J. R. Meteorol. Soc.,139, 515-523. Van Leeuwen, P. J., 2011: Efficient non-linear data assimilation in geophysical fluid dynamics. - Computers and Fluids, doi:10,1016/j.compfluid.2010.11.011, 1096 2011. Würsch, M. and G. C. Craig, 2013: A simple dynamical model of cumulus convection for data assimilation research, submitted to Met. Zeitschrift.

Crystal chemistry of hydrous phases in the Al2O3-Fe2O3-H2O system: implications for water cycle in the deep lower mantle

NASA Astrophysics Data System (ADS)

Zhang, L.

2016-12-01

Hydrous minerals play an important role in the transportation and storage of water in the Earth's interior. Recently a pyrite-structured iron oxide (FeO2) (P-phase) was found stable at 76 GPa and 1800 K [1] and this discovery has brought new insights into the H2-O2 cycles in the deep mantle. In this study, we perform in situ synchrotron X-ray experiments in the Al2O3-Fe2O3-H2O system in a laser-heated diamond anvil cell (DAC) at P-T conditions in the deep lower mantle. The new results added more complexity to the H2-O2/H2O cycles in the deep lower mantle. The symmetry and unit-cell parameters of each phase in the run products were determined using the multigrain approach [2]. On the other hand, the d-H solid solution AlOOH-MgSiO2(OH)2 is the stable hydrous phase coexisting with bridgmanite or post-perovskite under equilibrium P-T conditions to the deepest lower mantle [3]. The detailed crystal chemistry of the newly found hydrous phases and its relations to the d-H phase have been investigated using both first-principles calculations and experiments, providing new understanding to the hydration mechanism and water storage in the deep mantle. It is worth mentioning that recent development in high pressure multigrain method has realized separation of each individual phase in a multiphase assemblage and even allowed in situ crystal structure determination of a minor phase in the assemblage contained in a DAC [4]. [1] Q. Hu, D. Y. Kim, W. Yang, L. Yang, Y. Meng, L. Zhang, and H. K. Mao, Nature 534, 241 (2016). [2] H. O. Sørensen et al., Zeitschrift für Kristallographie 227, 63 (2012). [3] I. Ohira, E. Ohtani, T. Sakai, M. Miyahara, N. Hirao, Y. Ohishi, and M. Nishijima, Earth and Planetary Science Letters 401, 12 (2014). [4] L. Zhang, D. Popov, Y. Meng, J. Wang, C. Ji, B. Li, and H.-k. Mao, American Mineralogist 101, 231 (2016).

Plausibility check of a redesigned rain-on-snow simulator (RASA)

NASA Astrophysics Data System (ADS)

Rössler, Ole; Probst, Sabine; Weingartner, Rolf

2016-04-01

Rain-on-snow events are fascinating but still not completely understood processes. Although, several studies and equations have been published since decades that describe past events and theoretical descriptions, empirical data of what is happening in the snow cover is far less available. A way to fill this gap of empirical data, rain-on-snow-simulators might be of help. In 2013, Juras et al. published their inspiring idea of a portable rain-on-snow simulator. The huge advantage of this devise - in contrast to other purely field-based experiments - are their fixed, and mostly standardized conditions and the possibility to measure all required data to monitor the water fluxes and melting processes at a time. Mounted in a convenient location, a large number of experiments are relatively easy conductible. We applied and further developed the original device and plausified the results of this redesigned version, called RASA. The principal design was borrowed from the original version being a frame with a sprinkler on top and a snow sample in a box at the bottom, from which the outflow is measured with a tipping gauge. We added a moving sprinkling plate to ensure a uniform distribution of raindrops on the snow, and - most importantly - we suspended the watered snow sampled on weighting cells. The latter enables to continuous measurement of the snow sample throughout the experiment and thus the indirect quantification of liquid water saturation, water holding capacity, and snowmelt amount via balance equations. As it is remains unclear if this device is capable to reproduce known processes, a hypothesis based plausibility check was accomplished. Thus, eight hypothesizes were derived from literature and tested in 28 experiments with the RASA mounted at 2000 m elevation. In general, we were able to reproduce most of the hypotheses. The RASA proved to be a very valuable device that can generate suitable results and has the potential to extend the empirical-experimental data set on rain-on-snow events. Juras R., et al. (2013): A portable simulator for investigating rain-on-snow events, Zeitschrift für Geomorphologie, 57, Suppl.1, 73-89.

Precise determination of cosmogenic Ne in CREU-1 quartz standard, using the Helix-MC Plus mass spectrometer

NASA Astrophysics Data System (ADS)

Hamilton, D.; Honda, M.; Zhang, X.; Phillips, D.; Matchan, E.

2017-12-01

The Helix-MC Plus multi-collector noble gas mass spectrometer at the Australian National University is uniquely equipped with three high mass resolution collectors on H2, Axial and L2 positions. Their mass resolution and mass resolving power are as high as 1,800 and 8,000, respectively. The Helix-MC Plus can totally separate 20Ne+ from 40Ar++ isobaric interference and also partially separate 21Ne+ from 20NeH+ and 22Ne+ from 12C16O2++. By adjusting collector positions, we are able to measure interference-free Ne isotope intensities and have re-determined the 21Ne abundance in air [1]. Analyses by Honda et al. [1] demonstrated that 20Ne1H contributes approximately 2% to previously determined atmospheric 21Ne values [2], and a new atmospheric 21Ne/20Ne ratio of 0.002906 was calculated. Using the Helix-MC Plus mass spectrometer, we measured Ne abundances in the CREU-1 quartz standard [3] and determined cosmogenic concentrations by subtraction of atmospheric Ne with the new atmospheric 21Ne/20Ne value. The average concentration of cosmogenic 21Ne determined from four repeated analyses is 338 ± 12 × 106 atom/g (2σ). This compares with the average concentration of 348 ± 10 × 106 atom/g (2σ) from 45 analyses determined by several laboratories [3], where Ne isotope analyses were undertaken by conventional low resolution mass spectrometers and atmospheric Ne was subtracted using the conventional atmospheric 21Ne/20Ne [2]. On this basis, for a sample with abundant cosmogenic Ne, like CREU-1 quartz, previously measured by low mass resolution mass spectrometers are likely valid and their geological implications are unaffected. However, for low 21Ne concentration samples, combining new generation of mass spectrometers as well as the new atmospheric ratio may have significance for cosmogenic 21Ne surface exposure dating. References: [1] Honda M., et. al., International Journal of Mass Spectrometry, 387, 1 (2015). [2] Eberhardt P., et. al., Zeitschrift fur Naturforschung, 20a, 623 (1965). [3] Vermeesch P., et. al., Quaternary Geochronology, 26, 20 (2015).

Conceptual framework alignment between primary literature and education in animal behaviour

NASA Astrophysics Data System (ADS)

Bierema, Andrea Marie-Kryger

In 1963, Tinbergen revolutionized the study of animal behaviour in his paper On aims and methods of ethology (Zeitschrift Tierpsycholgie, 20, 410-433) by revamping the conceptual framework of the discipline. His framework suggests an integration of four questions: causation, ontogeny, survival value, and evolution. The National Research Council Committee (U.S.) on Undergraduate Biology Education to Prepare Research Scientists for the 21st Century published BIO2010: Transforming Undergraduate Education for Future Research Biologists (Washington, DC: The National Academies Press, 2003), which suggests alignment between current research and undergraduate education. Unfortunately, alignment has been rarely studied in college biology, especially for fundamental concepts. The purpose of this study, therefore, is to determine if the conceptual framework used by animal behaviour scientists, as presented in current primary literature, aligns with what students are exposed to in undergraduate biology education. After determining the most commonly listed textbooks from randomlyselected animal behaviour syllabi, four of the most popular textbooks, as well as the course descriptions provided in the collected syllabi, underwent content analysis in order to determine the extent that each of Tinbergen's four questions is being applied in education. Mainstream animal behaviour journal articles from 2013 were also assessed via content analysis in order to evaluate the current research framework. It was discovered that over 80% of the textbook text covered only two of Tinbergen's questions (survival value and causation). The other two questions, evolution and ontogeny, were rarely described in the text. A similar trend was found in journal articles. Therefore, alignment is occurring between primary literature and education, but neither aligns with the established conceptual framework of the discipline. According to course descriptions, many instructors intend to use an integrated framework in their courses. Utilizing an integrated framework within textbooks and teaching this framework is recommended in order to increase the number of scientists in the next generation that study evolution and ontogeny of behaviour. In order to use an integrated framework in animal behaviour textbooks and courses primary literature from mainstream and less mainstream behaviour journals, as well as broader biology journals, are necessary.

PREFACE: Nanosafe2010: International Conference on Safe Production and Use of Nanomaterials

NASA Astrophysics Data System (ADS)

Sentein, Carole; Schuster, Frédéric; Tardif, François

2011-07-01

Conference logo The second edition of the international conference on the "Safe production and use of nanomaterials" - NanoSafe2010 - was held between 16-18 November at the Maison Minatec congress center located in Grenoble, France. As is recognised, the rapidly developing field of nanotechnologies presents many opportunities and benefits for new materials with significantly improved properties as well as revolutionary applications in the fields of energy, environment, medicine, etc. However, the potential impact of these new materials on human health and the environment is viewed with apprehension. All the security aspects have to be solved in order to reach an acceptable level of risk. The new nano industry can only develop dynamically if these legitimate concerns are satisfactory allayed. Initiated within the framework of the Integrated European project NanoSafe2 and funded by the European Commission under FP6 programs, this biennial event was organized by the French Commissariat à l'Energie Atomique (CEA). NanoSafe2010 had broad international participation from 30 countries representing 4 continents, with registered delegates numbering over 300. The scientific program involved the presentation and discussion of 175 papers, classified as 13 plenary lectures, 117 oral presentations and 45 posters. The conference attracted many of the best known leading scientists and specialists from almost all of the different fields of expertise covering nanosafety issues: Exposure, Characterisation, Detection, Monitoring, Life cycle, Toxicology, Environmental impact, Personal protection, Secure industrial production, Safety parameter evaluation, Standardization, Regulation, and Education. An exhibition took place in parallel with the conference where 16 exhibitors presented the commercial equipment available today in relation to safety during the production or the use of nanomaterials. We believe that this conference, with the above topics, has provided a forum where the many matters of interest to the NanoSafety community have been debated. The success of the conference confirms the need of such a global meeting with the aim of bridging the gap between the best scientists, engineers, exhibitors and participants from countries concerned with safe and responsible nanomaterial activities. Therefore, the third edition of the International NanoSafe Conference "NanoSafe2012" will be held in Grenoble at Minatec, 13-15 November 2012. The meeting was financially supported by generous contributions from the European Commission, La Région Rhône Alpes, la Ville de Grenoble, la Metro, and partners such as CEA, INERIS, Philips, Cordouan Technologies, Nanosight, TSI, Ecomesure, GRIMM Aerosol Technik, Particle Measuring Systems, Respirex, Lux Research, Dekati, Malvern Instruments, TSE Systems, INTERTEK ICS, NANO magazine and IOP Publishing. We would like to express our thanks to all the authors for their time and genuine efforts and to the reviewers for their fruitful comments during the preparation of this volume. The Conference OrganizersCarole SenteinFrédéric SchusterFrançois Tardif Conference photographs Local Organising CommitteeCarole SENTEIN (CEA)Dominique BAGUET (CEA)Didier MOLKO (MINATEC)Audrey SCARINGELLA (MINATEC)Frédéric SCHUSTER (CEA)François TARDIF (CEA) International Advisory CommitteeChair: Frédéric SCHUSTER (CEA, FR), François TARDIF (CEA, FR)Co-chair: Georgios KATALAGARIANAKIS (EC, BE)Paul AMYOTTE (Dalhousie U., CA)Mélanie AUFFAN (CEREGE, FR)Daniel BERNARD (ARKEMA, FR)Jorge BOCZKOWSKI (INSERM, FR)Jean-Yves BOTTERO (CEREGE, FR)Jacques BOUILLARD (INERIS, FR)Jean-Philippe BOURGOIN (CEA, FR)Marie CARRIERE (CEA, FR)Krunal CHOPRA (LSFI, IN)Rolf ECKHOFF (U. Bergen, NO)Michael ELLENBECKER (U. Massachusetts, USA)Claude EMOND (U. Montréal, CA)François GENDARMES (IRSN, FR)Peter HATTO (ISO, UK)Peter HOET (KUL, BE)Jean-Pierre KAISER (Empa, CH)Olivier LE BIHAN (INERIS, FR)Tinh NGUYEN (NIST, USA)Bernd NOWACK (Empa, CH)Günter OBERDÖRSTER (U. Rochester, USA)David PUI (U. Minnesota, USA)Eric QUEMENEUR (CEA, FR)Robert SCHALLER (EPFL, CH)Carole SENTEIN (CEA, FR)Ken TAKEDA (U. Tokyo, JP)Louis TREPIED (MINEFE, FR)Jacques VENDEL (IRSN, FR)Olivier WITSCHGER (INRS, FR) List of Participants AGUY SCordouan, FR ALLEMAN LEcole des Mines de Douai, FR ALPER MUniv. California Berkeley, US ALVES O LUNICAMP, BR AMDAOUD MUniv. Joseph Fourier, FR AMODEO TINERIS, FR AMYOTTE PDalhousie Univ., CA ARAKELIAN M CFundacion Argentina de Nanotecnologia, AR ARZAMASTSEVA ETomsk Polytechnic Univ., RU ASCHBERGER KEuropean Commission-JRC, IT ASHTON AJPCS, GB ASIMAKOPOULOU ACERTH/CPER, GR AUBLANT J-MLNE, FR AUDE-GARCIA CCEA, FR AUFFAN MCEREGE, FR AUGER ACEA, FR BAEK MSeoul Woman's Univ., KR BAEZA AUniv. Paris 7 Diderot, FR BAGUET DCEA, FR BARONE FIstituto Superiore di Sanità, IT BAU SINRS, FR BELLEVILLE PCEA, FR BENAZET SSNPE-Matériaux Energétiques, FR BERGER L-MFraunhofer Institute, DE BERGES MDGUV-IFA, DE BERNARD CNIST, US BERNARD DARKEMA, FR BERNE PCEA, FR BERRET J-FUniv. Paris 7 Diderot, FR BIGORGNE ECNRS, FR BILLAT BPMS, FR BLOCH DCEA, FR BOGDANOVIC-GUILLON AFreelance journalist, FR BOIVIN DRESPIREX France, FR BOLAND SUniv. Paris 7 Diderot, FR BOMBARDIER PFAURE QEI, FR BORASCHI DInstitute of Biomedical Technologies, IT BOTTERO J-YCEREGE, FR BRADLEY JLux Research, US BREGOLI LVeneto Nanotech, IT BRIGNON J-MINERIS, FR BROCHOT CIRSN, FR BROUWER DTNO Quality of Life, NL BUDIMAN TTSE-Systems, DE CABOCHE JEcole des Mines de Douai, FR CALLET GCEA, FR CALOGINE DINERIS, FR CAPONIGRO ALoreal, FR CARRIERE MCEA, FR CASSETTE SThales Research & Technology, FR CHARPENTIER DINERIS, FR CHEN C-CTaiwan Univ., TW CHEN LHealth Canada, CA CHEVALLET MCEA, FR CHOI S-JSeoul Woman's Univ., KR CHOU C-CChung Cheng University, TW CHUNG H-ESeoul Woman's Univ., KR CIMPAN MUniv. Bergen, NO CIOBANU NTU Munich, DE CLARK KInstitute for Work and Health, CH CONJEAUD HUniv. Paris 7 Diderot, FR COSTA PEREIRA CNational Health Institute, PT CROOKS MTSI, GB CUPERTINO DC-Tech Innovation Ltd, GB DASKALOS MCERTH/CPERI, GR DE BERARDIS BIstituto Superiore di Sanità, IT DE MIGUEL YTECNALIA, ES DELAHAYE AAd Air Solutions, FR DEMIDOVA TSevertsov Inst. of Ecology and Evolution, RU DENOO KSolae, GR DERROUGH SCEA, FR DOBRZYNSKA E BCentral Institute for Labour Protection, PL DOLEZ PÉcole de technologie supérieure, CA DOUKI TCEA, FR DRAIS EINRS, FR DUFOUR J-PCILAS, FR DURAN NUNICAMP, BR DURAND CCEA, FR DUTOUQUET CINERIS, FR DUVAL-ARNOULD GSaint-Gobain, FR ECKHOFF R KUniv. Bergen, NO ELLENBECKER M JUniv. Massachusetts Lowell, US EMOND CUniv. Montreal, CA ENGEL SBASF, DE ESTRELA-LOPIS ILeipzig Univ., DE FABBRI MJRC, IT FACCINI MLeitat technological center, ES FESSARD VAnses, FR FILIMUNDI ETSI, DE FIRSTOVA VSRCAMB, RU FLEURY DINERIS, FR FRABOULET DCEA, FR FRESNAY CThales Research & Technology, FR GABORIEAU ACEA, FR GAFFET ENanoMaterials Research Group, FR GALLET SCefic, BE GEIGER DBASF, DE GENSDARMES FIRSN, FR GERRITSEN-EBBEN RTNO Quality of Life, NL GKANIS VDemokritos, GR GLUSHKOVA ARIHOPHE, RU GONZALEZ-FERNANDEZ AUniv. Vigo, ES GOOSSENS HPhilips Research Aerasense, NL GRAHNSTEDT SOslo Univ., NO GREENHILL-HOOPER MRio Tinto Minerals, FR GROSSEAU PEcole des Mines de Saint Etienne, FR GUADAGNINI RUniv. Paris 7 Diderot, FR GUIOT ACEA, FR GUIZARD BCEA, FR HAASE AFederal Institute for Risk Assessment, DE HANINI AUniv. Paris 7 Diderot, FR HAYNES LUniv. de los Andes, VE HEJAZI MUniv. Tehran, IR HENRY FINERIS, FR HERRERA HInstitute for Work and Health, CH HOET PKU Leuven, BE HOLE PNanosight, GB HULME JUniv. Cambridge, GB JI XINERIS, FR JOUHANNAUD JCEA, FR JOUZEL J-NCenter for the Sociology of Organizations, FR JURKSCHAT KOxford Univ., GB KAISER J-PEmpa, CH KANAYA FNat. Center for Global Health and Medicine, JP KATALAGARIANAKIS GEuropean Commission, BE KECK LGrimm Aerosol Technik, DE KELLER MFraunhofer Institute, DE KHLEBNIKOVA NRIHOPHE, RU KHODABANDEH MUniv. Tehran, IR KHOLODENKO VSRCAMB, RU KOBAYASHI NAIST, JP KOPONEN INRCWE, DK KOWAL SINERIS, FR KRYSANOV ESevertsov Inst. of Ecology and Evolution, RU KÜCK AUniv. Bremen, DE KUO Y-MChung Hwa University, TW KVITEK LPalacky Univ., CZ LABILLE JCEREGE, FR LAMMINEN EDekati, FI LARUE CCEA, FR LE BIHAN OINERIS, FR LE DUR DEcomesure, FR LECERF PCILAS, FR LEGRAND MCordouan, FR LELONG CUJF CEA, FR LIMOUSIN SINERIS, FR LINDELOEV JGEA Process Engineering, DK LIU P PChina Jiliang University, CN LIU WCEREGE, FR MACHEREY A-CCNRS, FR MAGGA YCEA, FR MAHLENDORF FUniversity Duisburg-Essen, DE MANIER NINERIS, FR MANZO LUniv. Pavia, IT MARCHETTO ACEA, FR MARCONE GUNICAMP, BR MARI DEPFL, CH MARIE-DESVERGNE CCEA, FR MARIE-LOUISE APSA Peugeot-Citroen, FR MARMUSE LNano-H S.A.S., FR MARRA JPhilips Research Aerasense, NL MASION ACEREGE, FR MATEI EPolitehnica University Bucharest, RO MATSUI YKyoto Univ., JP MATZKE MUniv. Gothenburg, SE MAYNE-L'HERMITE MCEA, FR MELINTE G ABabes-Bolyai University, RO MERINO CGrupo Antolin Ingenieria, ES MICHAUD-SORET ICEA, FR MICHELETTI CJRC, IT MONTIGEL EBasler Versicherungen, CH MONTOYA ERAMEM, ES MOSSUZ VCEA, FR MOTELLIER SCEA, FR MOTZKUS CLNE, FR MUIR BNaneum, GB NAKAMURA KJAPAN NUS CO., JP NEUBAUER NKarlsruhe Institute of Technologie, DE NEUMEISTER LBG ETEM, DE NGUYEN TNIST, US NIORT NINTERTEK, FR NOIRTIN AINTERTEK, FR NOWACK BEmpa, CH NYEMBE DUniv. Johannesburg, ZA Ó CLAONADH NDublin Institute of Technology, IE OBERDÖRSTER GUniv. Rochester, US OGURA IAIST, JP OSTIGUY CIRSST, CA OTSUKA KJFE Techno-Research Corp., JP OUF F-XIRSN, FR OUSACI SALMA, FR PAGET VCEA, FR PAILLEUX MEcole des Mines de Saint Etienne, FR PANDARD PINERIS, FR PANZER OEuropean Research Services, DE PARISELLI FCNRS, FR PERLET JNANO Magazine, GB PETERS RRIKILT, NL PETIT A-NCEA, FR PETKOVIC JNational Institute of Biology, SI PIMENOFF JBeneq, FI PINAULT MCEA, FR PIRET J-PUniv. Namur, BE PONTONE RTekna Plasma Systems, FR POURCHEZ JEcole des Mines de Saint Etienne, FR PRAETORIUS AETH Zurich, CH PRAT OCEA, FR PREVENSLIK TQED Radiations, CN PREVOST CIRSN, FR PROY HUART DFrance Nature Environnement, FR PUI D Y HUniv. Minnesota, US QUARTARARO JPSA Peugeot-Citroen, FR RAULT SUniv. Caen, FR RAVANEL XCEA, FR RAVINDRAN GIRIJA AToyo Univ., JP REBIB FPôle Technologique d'Auvergne, FR RECHATIN J-LIRELEC, FR REYNIER MINRS, FR RICAUD MINRS, FR RIEDIKER MInstitut de Santé au Travail, CH RMILI BINERIS, FR ROGERIEUX FINERIS, FR ROLANDO CUniv. Lille 1, FR ROMERO AFreelance journalist, DE ROUCHER BCILAS, FR SAEZ J-PNanosight, GB SAFI MUniv. Paris 7 Diderot, FR SAKAI NKyoto Univ., JP SALVI OINERIS, FR SANFINS EUniv. Paris 7 Diderot, FR SAVOLAINEN KFIOH, FI SCHALLER REPFL, CH SCHMID KInstitute for Work and Health, CH SCHUBERT CCEA, FR SCHUSTER FCEA, FR SCHWEINBERGER FTU Munich, DE SCIFO LTECNALIA, ES SEABRA AUNICAMP, BR SEBASTIEN PSaint-Gobain, FR SENE CSTEPAN, FR SENTEIN CCEA, FR SHEN JStockholm Univ., SE SHINKAI YTokyo Univ., JP SICARD YUJF CEA, FR SIKHWIVHILU LNat. Centre for Nanostructured Materials, ZA SILLANPÄÄ MFinnish Environment Institute, FI SIMON JCEA, FR SINESI SCRP, IT SIRVEN J-BCEA, FR SIRVIÖ SFIOH, FI SOERENSEN SSolae, DK SON S WKorea Univ., KR SUBLEMONTIER OCEA, FR SYMON ARUSNANO Metrology Center, RU SYMONDS JCAMBUSTION, GB TARANTINI AAnses, FR TARDIF FCEA, FR TAKEDA KTokyo Univ., JP TERRAY MMalvern Instruments, FR THABUIS CBureau Veritas, FR THIERIET NAnses, FR TIKKANEN JTHL, FI TROUILLER BINERIS, FR UKKONEN ADekati, FI UMEMURA KTokyo University, JP USTACHE AINERIS, FR VÄISÄNEN PRautaruukki Oyj, FI VAN DEN BRINK WPhilips Research Aerasense, NL VAN TONGEREN MInstitute of Occupational Medicine, GB VANDELAC LUniv. Québec, CA VAQUERO CTECNALIA, ES VEERANARAYANAN SToyo Univ., JP VENDEL JIRSN, FR VERBIST KArboUnie, NL VIANA MIDAEA-CSIC, ES VIDAUD CCEA, FR VIGNES AINERIS, FR VOETZ MBayer Technology Services, DE WAHLBERG MGEA Process Engineering, DK WALSER T DETH Zurich, CH WARTENBERG NCEA, FR WEIGEL SRIKILT, NL WENZLER ETSE-Systems, DE WHITELEY CLancaster Univ., GB WIJMA ERIKILT, NL WILDE CAvantiCell Science Ltd, GB WILLIAMS DManufacture Michelin, FR WITSCHGER OINRS, FR WOHLLEBEN WBASF, DE WU QDet Norske Veritas, NO YAGISHITA TJFE Techno-Research Corporation, JP YU JSeoul Woman's Univ., KR ZAPÓR LCIOP-PIB, PL ZIMMERMANN ECEA, FR

76 FR 37165 - Self-Regulatory Organizations; Fixed Income Clearing Corporation; Notice of Filing and Order...

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48 CFR 9.104-1 - General standards.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., 1983, as amended at 51 FR 27119, July 29, 1986; 56 FR 55374, Oct. 25, 1991; 60 FR 16718, Mar. 31, 1995; 61 FR 67410, Dec. 20, 1996; 65 FR 80264, Dec. 20, 2000; 66 FR 17756, Apr. 3, 2001; 66 FR 66986, 66989, Dec. 27, 2001; 73 FR 67091, Nov. 12, 2008; 74 FR 31563, July 1, 2009; 76 FR 31413, May 31, 2011] ...

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40 CFR 141.51 - Maximum contaminant level goals for inorganic contaminants.

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EMPOWER-support of patient empowerment by an intelligent self-management pathway for patients: study protocol.

PubMed

Mantwill, Sarah; Fiordelli, Maddalena; Ludolph, Ramona; Schulz, Peter J

2015-03-20

Diabetes education together with patient empowerment has shown to be key to effective self-management behavior. When delivered through information and communication technologies (ICT), this solution has shown to lead to better health outcomes. However, the potential of ICT and their integration into the healthcare environment have not yet been fully exploited. ICT should be in particular used to facilitate communication and information exchange between patient and healthcare providers. In addition, systems should include components facilitating behavior change using empowerment approaches such as goal-setting. Funded by the European Commission (FP7-ICT-2011-288209) a web/mobile based platform (EMPOWER) has been developed, which aims at supporting self-management activities of diabetes patients and their treating physicians in Germany and Turkey. The platform semantically integrates multiple information sources, such as electronic and personal health records (EHR/PHR). Patients can register patterns of daily living, record blood glucose levels, design disease management plans and set long- and short-term goals. The project actively involves the treating physician, who has the possibility to set recommendations for the patient and to monitor his/her progress on the platform. In the test-phase of EMPOWER, patients will be assigned to an intervention group and a control group. Data will be collected at baseline and three months after the intervention started. In addition, qualitative interviews will be conducted to collect extra information on usability and usefulness. Outcome measures include amongst others the Problem Areas in Diabetes questionnaire (PAID), the Summary of Diabetes Self-Care Activities and scales evaluating doctor-patient interaction. Physiological parameters, such as physical activity or blood glucose levels will be collected via the platform. Further, log files and number of logins will serve as independent variables. The interplay between multiple sources, including EHR, patients' own registered information and physicians' recommendations on one platform can have important practice implications. It might not only improve self-management activities in diabetes patients but it will also facilitate physician's work, and ultimately the physician patient relationship. The trial has been registered with Deutsches Register Klinischer Studien (German register of clinical trials) under DRKS00007699 on January 30, 2015.

Impact of preoperative Vitamin D3 administration on postoperative hypocalcaemia in patients undergoing total thyroidectomy (HypoCalViD): study protocol for a randomized controlled trial.

PubMed

Wolak, Stefanie; Scheunchen, Mandy; Holzer, Katharina; Busch, Mirjam; Trumpf, Esra; Zielke, Andreas

2016-02-20

Total thyroidectomy is increasingly used as a surgical approach for many thyroid conditions. Subsequently, postoperative hypocalcaemia is observed with increasing frequency, often resulting in prolonged hospital stay, increased use of resources, reduced quality of life and delayed return to work. The administration of vitamin D is essential in the therapy of postoperative hypocalcaemia; calcitriol is most commonly used. What has not been examined so far is whether and how routine preoperative vitamin D prophylaxis using calcitriol can help to prevent postoperative hypocalcaemia. This study evaluates routine preoperative calcitriol prophylaxis for all patients who are to undergo a total thyroidectomy, compared with the current standard of post-treatment, i.e., selective vitamin D treatment for patients with postoperative hypocalcaemia. This clinical observational (minimal interventional clinical trial) trial is a multicentre, prospective, randomized superiority trial with an adaptive design. Datasets will be pseudonymized for analysis. Patients will be randomly allocated (1:1) to the intervention and the control groups. The only intervention is 0.5 μg calcitriol orally twice a day for 3 days prior to surgery. For the primary endpoint measure (number of patients with hypocalcaemia), hypocalcaemia is defined as serum calcium of less than 2.1 mmol/l on any day during the postoperative course; this measure will be analyzed using a Chi-square test comparing the two groups. Secondary endpoint measures, such as number of days to discharge, quality of life, and economic parameters will also be analyzed. By virtue of the direct comparison of clinically and economically relevant endpoints, the efficacy as well as efficiency of preoperative calcitriol prophylaxis of hypocalcaemia will be clarified. These results should be available 24 months after the first patient has been enrolled. The results will be used to inform a revised practice parameter guideline of whether or not to recommend preoperative calcitriol for all patients in whom total thyroidectomy is planned. Deutsches Register Klinischer Studien, DRKS00005615 (Feb.12.2016).

Whole body vibration compared to conventional physiotherapy in patients with gonarthrosis: a protocol for a randomized, controlled study.

PubMed

Stein, Gregor; Knoell, Peter; Faymonville, Christoph; Kaulhausen, Thomas; Siewe, Jan; Otto, Christina; Eysel, Peer; Zarghooni, Kourosh

2010-06-21

Osteoarthritis (OA) is the most common degenerative arthropathy. Load-bearing joints such as knee and hip are more often affected than spine or hands. The prevalence of gonarthrosis is generally higher than that of coxarthrosis.Because no cure for OA exists, the main emphasis of therapy is analgesic treatment through either mobility or medication. Non-pharmacologic treatment is the first step, followed by the addition of analgesic medication, and ultimately by surgery.The goal of non-pharmacologic and non-invasive therapy is to improve neuromuscular function, which in turn both prevents formation of and delays progression of OA. A modification of conventional physiotherapy, whole body vibration has been successfully employed for several years. Since its introduction, this therapy is in wide use at our facility not only for gonarthrosis, but also coxarthrosis and other diseases leading to muscular imbalance. This study is a randomized, therapy-controlled trial in a primary care setting at a university hospital. Patients presenting to our outpatient clinic with initial symptoms of gonarthrosis will be assessed against inclusion and exclusion criteria. After patient consent, 6 weeks of treatment will ensue. During the six weeks of treatment, patients will receive one of two treatments, conventional physiotherapy or whole-body-vibration exercises of one hour three times a week. Follow-up examinations will be performed immediately after treatment and after another 6 and 20 weeks, for a total study duration of 6 months. 20 patients will be included in each therapy group.Outcome measurements will include objective analysis of motion and ambulation as well as examinations of balance and isokinetic force. The Western Ontario and McMaster Universities Arthritis Index and SF-12 scores, the patients' overall status, and clinical examinations of the affected joint will be carried out. As new physiotherapy techniques develop for the treatment of OA, it is important to investigate the effectiveness of competing strategies. With this study, not only patient-based scores, but also objective assessments will be used to quantify patient-derived benefits of therapy. Deutsches Register Klinischer Studien (DRKS) DRKS00000415Clinicaltrials.gov NCT01037972EudraCT 2009-017617-29.

Primary palliative Care in General Practice - study protocol of a three-stage mixed-methods organizational health services research study.

PubMed

Ewertowski, Helen; Tetzlaff, Fabian; Stiel, Stephanie; Schneider, Nils; Jünger, Saskia

2018-01-30

The focus of this project is on improving the provision of primary palliative care (PC) by general practitioners (GPs). While approximately 10-15% of the incurable, seriously ill or dying people will be in need of specialist PC, the vast majority can be adequately treated within generalist care. The strengthening of the GP's role in PC, as well as ensuring close collaboration between specialist PC services and GPs have been identified as top priorities for the improvement of PC in Germany. Despite healthcare policy actions, diverse obstacles still exist to successful implementation of primary PC on a structural, process, and economic level. Therefore, this project aims at addressing barriers and facilitators to primary PC delivery in general practice in Germany. The study follows a three-step approach; first, it aims at systematically analyzing barriers and facilitators to primary PC provision by GPs. Second, based on these outcomes, a tailored intervention package will be developed to enhance the provision of primary PC by GPs. Third, the intervention package will be implemented and evaluated in practice. The expected outcome will be an evidence-based model for successful implementation of primary PC delivery tailored to the German healthcare system, followed by a strategic action plan on how to improve current practice both on a local level and nationally. The first step of the project has been partly completed at the time of writing. The chosen methodologies of four sub-projects within this first step have opened up different advantages and disadvantages for the data collection. In sum of all sub-projects, the different methodologies and target groups contributed valuable information to the systematic analysis of barriers and facilitators to primary PC provision by GPs. The study (BMBF-FK 01 GY 1610) was retrospectively registered at the German Clinical Trials Register (Deutsches Register Klinischer Studien) (Registration N° DRKS00011821 ; date of registration: December 04th 2017) and at the German Register of health care research (Versorgungsforschung Deutschland - Datenbank) (Registration N° VfD_ALLPRAX_16_003817 ; date of registration: March 30th 2017).

Single dental implant retained mandibular complete dentures – influence of the loading protocol: study protocol for a randomized controlled trial

PubMed Central

2014-01-01

Background Over the years, there has been a strong consensus in dentistry that at least two implants are required to retain a complete mandibular denture. It has been shown in several clinical trials that one single median implant can retain a mandibular overdenture sufficiently well for up to 5 years without implant failures, when delayed loading was used. However, other trials have reported conflicting results with in part considerable failure rates when immediate loading was applied. Therefore it is the purpose of the current randomized clinical trial to test the hypothesis that immediate loading of a single mandibular midline implant with an overdenture will result in a comparable clinical outcome as using the standard protocol of delayed loading. Methods/design This prospective nine-center randomized controlled clinical trial is still ongoing. The final patient will complete the trial in 2016. In total, 180 edentulous patients between 60 and 89 years with sufficient complete dentures will receive one median implant in the edentulous mandible, which will retain the existing complete denture using a ball attachment. Loading of the median implant is either immediately after implant placement (experimental group) or delayed by 3 months of submerged healing at second-stage surgery (control group). Follow-up of patients will be performed for 24 months after implant loading. The primary outcome measure is non-inferiority of implant success rate of the experimental group compared to the control group. The secondary outcome measures encompass clinical, technical and subjective variables. The study was funded by the Deutsche Forschungsgemeinschaft (German research foundation, KE 477/8-1). Discussion This multi-center clinical trial will give information on the ability of a single median implant to retain a complete mandibular denture when immediately loaded. If viable, this treatment option will strongly improve everyday dental practice. Trial registration The trial has been registered at Deutsches Register Klinischer Studien (German register of clinical trials) under DRKS-ID: DRKS00003730 since 23 August 2012. (http://www.germanctr.de). PMID:24884848

Report of the 1st meeting of the "Vienna Initiative to Save European Academic Research (VISAER)".

PubMed

Druml, Christiane; Singer, Ernst A; Wolzt, Michael

2006-04-01

The European Directive 2001/20/EC ("Clinical Trials Directive") was aimed at simplifying and harmonising European clinical research. The directive's attempt represents an important step because many European Member States lack national laws that specifically address details of research, but the goal has been only partly achieved. For academic investigators doing national or multi-national research the new European law and the requirements following its implementation are likely to have the opposite effect. Some areas seem to be of particular concern: trial sponsorship, the ethical review process, the participation of patients who are temporarily not able to consent in clinical trials, in particular the informed consent process, an accepted European registry for all clinical trials, insurance and pharmacovigilance. Furthermore there are fundamental problems of the conduct of clinical trials that could have been foreseen at the time of implementation of the new law, which are impeding academic basic clinical research. The bureaucratic burden for academic investigators has tremendously increased without representing any contribution to patients' safety or to the scientific value of research. Furthermore some large European academic trials cannot be conducted anymore due to the new regulations. This result in a reduction in the number of trials and additionally in a reduction in the number of patients enrolled in a study. European research and thus European patients will suffer from the loss of potential benefits of research. The Vienna Initiative to Save European Academic Research (VISEAR) brings together leading stakeholders from academic research groups and interested parties from industry, international organisations and regulatory authorities to focus on the issues of concern regarding the organisational and funding of academic clinical research in order to improve the development and use of medicines in Europe. The first step of the initiative was a meeting held on May 30, 2005 in Vienna. The resumés of the six parallel working groups are presented in this supplement of the Wiener Klinische Wochenschrift, a position paper with recommendations in relation to the EU Clinical Trials Directive and medical research involving incapacitated adults has been published separately.

Reconstructing ancient sustainability: a comparison of onsite and offsite data

NASA Astrophysics Data System (ADS)

Lubos, Carolin; Dreibrodt, Stefan; Horejs, Barbara

2013-04-01

With the onset of sedentism humans started to convert their surroundings. Whereas reconstructions of geochemical traces of settlement activity (e.g. Arrhenius, 1931) or man's pressure on the soils of landscapes (e.g. van Andel et al., 1990; Bork, 1998) were carried out at many sites holistic approaches questioning the sustainability of ancient societies are missing so far. A new approach, applied to the multi layered settlement mound "Cukurici Höyük" (western Anatolia, Turkey) aims at comparing land use intensity and settlement intensity. Land use intensity of the former settlers will be described by determining slope instability phases and quantifying slope deposits at hills adjacent to the settlement. Geochemical and physical properties as well as bio remains will be analysed of the dated debris layers onsite and quantified as matter fluxes. Matter accumulation onsite, being an indicator for settlement intensities, is compared to slope instability phases offsite, describing the impact of former settlers on their environment. The approach aims at quantifying historical settlement pressure over several settlement phases and might shed light on different phases of sustainability in ancient Times. The planned project is imbedded within the archaeological project (ERC Project / Austrian Archaeological Institute) which investigates alternating societal systems in a changing environment between 7000 and 3000 BC. Focus is laid on architectural research, archaeobotany, archaeozoology, lithics, metallurgy, and ore deposit. In a first geoarchaeological field campaign differentiable slope deposits could be proved. These contained datable organic material as well as pottery sherds dating to different historical phases. A well-established archaeological chronosequence of settlement layers will provide the onsite framework for this new project. The paper presents preliminary results of the outlined approach. Additionally several geochemical methodologies applied to the debris layers will be compared. Ref: van Andel, T.H., Zangger, E., Demitrack, A., 1990. Land Use and Soil Erosion in Prehistoric and Historical Greece. Journal of Field Archaeology, Volume 17, Number 4, pp. 379-396 (18). Arrhenius, O., 1931. Die Bodenanalyse im Dienst der Archäologie. Zeitschrift für Pflanzenernährung, Düngung und Bodenkunde, Teil B10,pp. 427-439. Bork, H.-R., Bork, H., Dalchow, C., Faust, D., Piorr H.-P. und Schatz, T., 1998. Landschaftsentwicklung in Mitteleuropa. Wirkungen des Menschen auf Landschaften. Gotha (Klett-Perthes). 328 p.

The habit of crystals in aggregates: five parameter grain boundary characterization of olivine

NASA Astrophysics Data System (ADS)

Marquardt, K.; Rohrer, G. S.; Morales, L. F. G.; De Graef, M.; Farla, R. J.

2016-12-01

There is growing evidence that the presence of interfaces in rocks, including phase and grain boundaries influence macroscopic properties. To model resulting bulk rock properties and ultimately interpret geophysical signals, such as electrical conductivity, knowledge about the relative abundance of specific grain boundaries is needed. To date, neither the anisotropic frequency of appearance of specific grain boundaries nor its dependence on chemical composition is known for rock forming minerals. Here, we report detailed interface characterizations in olivine, the most abundant phase in the upper mantle. To obtain the area distribution of the geometrically varying interfaces, which is among the most fundamental information, we used electron backscatter diffraction (EBSD) to detect the orientations of over 3x104grains corresponding to more than 6000 mm length of grain boundary separating them. Subsequently we used a stereological approach to determine the grain boundary character distribution (GBCD), defined as the relative areas of grain boundaries of different types, distinguished by their five degrees of freedom (Rohrer et al. 2004). We discuss data collected from different olivine aggregates with chemical compositions ranging from Mg2SiO4 forsterite to Mg1.8Fe0.2SiO4 derived from different synthesis methods. We show that standard EBSD indexing as commonly used is sufficient for many applications, but when characterizing grain boundaries higher accuracy and precision is fundamental and provided by the new dictionary indexing approach, where clean up procedures, that can cause artifacts, are superfluous. The grain boundary planes show a preference for low index planes, which is in agreement with observations on other materials (e.g. MgO, TiO2, SrTiO3, MgAl2O4). We find that the principal crystallographic planes have the lowest energies resulting in crystal habits dominated by (001) planes, followed by (010) and (001) planes and that 90°/[001] (100)(010) are the most frequent grain boundaries, for pure forsterite aggregates. However in the absence of any impurities such as Al or Ca on the grain boundaries the (001) planes dominate the crystal habits. Rohrer G. S. et al. (2004) The distribution of internal interfaces in polycrystals. Zeitschrift für Met. 95, 197-214.

Possible Detection of Solar Neutrons from the ISS

NASA Astrophysics Data System (ADS)

Benker, Nicole; Echeverria-Mora, Elena; Hamblin, Jennifer; Dowben, Peter A.; Enders, Axel; Kananen, Brant; Petrosky, James; McClory, John

2018-06-01

A low energy steady state solar neutron flux has been long predicted [1]. The Detector for the Analysis of Solar Neutrons (DANSON), designed to detect this flux, was launched on the OA-5 mission to the International Space Station (ISS) on 17 Oct. 2016, deployed aboard ISS, and returned 19 March 2017. This detector is insensitive to high energy solar neutron events associated with solar flares, which have now been routinely detected in the range of 40 to 140 MeV, but the lower energy steady state solar neutron background has not been thoroughly examined. DANSON is based on boron rich detector elements combined with a plastic moderator to thermalize neutrons at energies above 40 meV, maximizing the B10 capture of epithermal neutrons. The detector elements include boron carbide (B10C2HX) heterojunction diodes on silicon and lithium tetraborate (Li2B4O7) single crystals. Three types of lithium tetraborate detector elements are used: crystals with a natural abundance of 10B (approx. 20% 10B, 80% 11B), crystals enriched in 10B, and crystals enriched in 11B. Enrichment in 10B provides a higher cross section for thermal neutron capture, while enrichment in 11B results in a negligible cross section for thermal neutron capture while maintaining a proton capture cross section comparable to that of 10B. The signature of neutron capture in the lithium tetraborate samples is evident in the thermoluminescent spectra. In the boron carbide diodes, the signature is measured in the huge decrease in drift carrier lifetimes compared to pre-flight characterization data, corresponding to about 3×109 neutrons/cm2 exposure. Since the estimated total solar exposure time for deployment is 8×106 seconds, this amounts to about 250 to 375 neutrons and protons/cm2sec. The detector package shows increased detection on the zenith side of ISS, after subtraction of radiation events from energetic protons and other sources, indicating possible detection of solar neutrons. Additionally, detection of events on the nadir side implies detection of cosmic ray generated neutrons.[1] Biermann VL, Haxe O, Schulter A (1951) Neutrale Ultrastrahlung von der Sonne. Zeitschrift für Naturforschung 6a: 47-48.

TG/DTG/DTA evaluation of flame retarded cotton fabrics and comparison to cone calorimeter data.

PubMed

Šimkovic, Ivan

2012-10-01

Unbleached cotton fabrics (UCF) with 12.5% polypropylene scrim treated with two phosphate-urea based fire-retardant (FR) formulations were evaluated for FR properties using thermogravimetry/differential thermogravimetry/differential thermal analysis (TG/DTG/DTA) method. In addition to testing the two FR-treated unbleached cotton fabrics (CF-FR1 and CF-FR2), bleached cotton fabric (BCF) treated with the two FR formulations (BCF-FR1 and BCF-FR2) was evaluated. Both formulations were washable with add-on of FR chemicals at 18.7% (FR1) or 17.4% (FR2) for UCF and 22.5% (FR1) or 24.9% (FR2) for BCF. The decreasing order of sums at maximal rates of samples degradation in air environment according to DTG method was: BCF (21.40%/min)>UCF (12.91%/min)>BCF-FR2 (12.83%/min)>BCF-FR1 (11.68%/min)>CF-FR2 (10.20%/min)>CF-FR1 (9.73%/min). It indicates that both formulations cause the decrease of thermooxidation of the products at slower rates than the starting material. Several endo- and exothermic peaks observed by DTA in inert and oxidative environment gives additional information about the degradation process. The order of decreasing thermal responses of the studied samples based on sums of DTA peak values of endothermic and exothermic peaks in air environment is: UCF (0.597 °C/mg)>BCF (0.120 °C/mg)>CF-FR1 (0.089 °C/mg)>BCF-FR1 (0.077 °C/mg)>CF-FR2 (0.062 °C/mg)>BCF-FR2 (0.053 °C/mg). This is in agreement with the cone calorimeter results according to which the flammability properties are improving with the decreasing heat release rates or ignition time prolongation in order: UCF>CF-FR1>CF-FR2. The advantage of TG/DTG/DTA method is slower linear heating rate, which allows the more detailed evaluation of the light and flammable cotton fabric. Copyright © 2012 Elsevier Ltd. All rights reserved.

76 FR 7101 - Airworthiness Directives; Hamilton Sundstrand Propellers Model 247F Propellers

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-09

..., except Federal holidays. The AD docket contains this AD, the regulatory evaluation, any comments received... blades part number (P/N) 817370-1, S/Ns FR2449 to FR2958 inclusive, FR20010710 to FR20010722 inclusive, and FR20010723RT to FR20020127RT inclusive, before December 31, 2010. We determined that those S/N...

75 FR 62333 - Airworthiness Directives; Hamilton Sundstrand Propellers Model 247F Propellers

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-08

...., Monday through Friday, except Federal holidays. The AD docket contains this proposed AD, the regulatory... that the 247F propeller blades, P/N 817370-1, S/Ns FR2449 to FR2958 inclusive, FR20010710 to FR20010722 inclusive, and FR20010723RT to FR20020127RT inclusive, manufactured since January 1999, might also have...

78 FR 24745 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-26

... Securities Dealer. Agency form number: FR MSD-4; FR MSD-5. OMB control number: 7100-0100; 7100-0101... are municipal securities dealers. Estimated annual reporting hours: FR MSD-4, 20 hours; FR MSD-5, 13 hours. Estimated average hours per response: FR MSD-4, 1 hour; FR MSD-5, 0.25 hours. Number of...

48 CFR 236.273 - Construction in foreign countries.

Code of Federal Regulations, 2010 CFR

2010-10-01

... foreign governments. [56 FR 36421, July 31, 1991, as amended at 62 FR 2856, Jan. 17, 1997; 62 FR 34127, June 24, 1997; 63 FR 11538, Mar. 9, 1998; 66 FR 49861, Oct. 1, 2001; 70 FR 35545, June 21, 2005...

48 CFR 236.273 - Construction in foreign countries.

Code of Federal Regulations, 2011 CFR

2011-10-01

... foreign governments. [56 FR 36421, July 31, 1991, as amended at 62 FR 2856, Jan. 17, 1997; 62 FR 34127, June 24, 1997; 63 FR 11538, Mar. 9, 1998; 66 FR 49861, Oct. 1, 2001; 70 FR 35545, June 21, 2005...

75 FR 19973 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-16

... Municipal Securities Dealer. Agency form number: FR MSD-4 and FR MSD-5. OMB control number: 7100-0100 and... activities as municipal securities dealers. Estimated annual reporting hours: FR MSD-4, 48 hours; and FR MSD-5, 36 hours. Estimated average hours per response: FR MSD-4, 1 hour; and FR MSD- 5, 0.25 hours...

12 CFR 620.4 - Preparing and providing the annual report.

Code of Federal Regulations, 2011 CFR

2011-01-01

... misleading. [51 FR 8656, Mar. 13, 1986. Redesignated and amended at 56 FR 29421, 29422, June 27, 1991; 62 FR 15093, Mar. 31, 1997; 66 FR 14301, Mar. 12, 2001; 67 FR 16633, Apr. 8, 2002; 71 FR 76119, Dec. 20, 2006...

77 FR 50163 - Affirmative Decisions on Petitions for Modification Granted in Whole or in Part

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-20

...: Docket Number: M-2009-050-C. FR Notice: 75 FR 3256 (1/20/2010). Petitioner: Wolf Run Mining Company, 300... Number: M-2011-010-C. FR Notice: 76 FR 22150 (4/20/2011). Petitioner: Brooks Run Mining Company, LLC, 208... systems). Docket Number: M-2011-012-C. FR Notice: 76 FR 37838 (6/28/2011). Petitioner: Patton Mining, LLC...

76 FR 58300 - Affirmative Decisions on Petitions for Modification Granted in Whole or in Part

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-20

... Affected: 30 CFR 75.1700 (Oil and gas wells). Docket Number: M-2009-005-C. FR Notice: 74 FR 23747 (May 20... CFR 75.1700 (Oil and gas wells). Docket Number: M-2009-006-C. FR Notice: 74 FR 23748 (May 20, 2009.... Regulation Affected: 30 CFR 75.1700 (Oil and gas wells). Docket Number: M-2009-039-C. FR Notice: 74 FR 63414...

Histological distribution of FR-1, a cyclic RGDS-peptide, binding sites during early embryogenesis, and isolation and initial characterization of FR-1 receptor in the sand dollar embryo.

PubMed

Katow, H; Yamamoto, Y; Sofuku, S

1997-04-01

A fibronectin-related synthetic cyclic H-Cys-Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Cys-OH (RGDSPASS) peptide (FR-1) binding site in the embryo of the sand dollar Clypeaster japonicus was specified using dansyl-labeled FR-1 (Dns-FR-1) and horseradish peroxidase-labeled FR-1, and an FR-1 receptor was isolated using FR-1-affinity column chromatography. The FR-1 introduced to the blastocoel of blastulae inhibited primary mesenchyme cell (PMC) migration in mesenchyme blastulae, and complete gastrulation and spicule differentiation in gastrulae. The Dns-FR-1 bound to the entire basal side of the ectoderm in mesenchyme blastulae, and then restricted to the basal side of the ectoderm at the apical tuft region and the vegetal hemisphere in early gastrulae. The cytoplasm of the archenteron also bound to Dns-FR-1. In PMC, Dns-FR-1 bound to the nucleus and cytoplasmic reticular features. In unfertilized eggs, Dns-FR-1 bound to the entire cytoplasm, particularly to the oval-shaped granules and the nuclear envelope, but only to the cytoplasm after fertilization. Relative molecular mass (Mr) of the FR-1-binding protein was 240 kDa under non-reducing conditions and 57 kDa under reducing conditions. The FR-1 receptor protein bound anti-sea urchin integrin (Spl) betaL subunit antibodies raised against the embryos of Strongylocentrotus purpuratus. Immunohistochemistry showed that the antibody binding site was similar to the histochemical distribution of Dns-FR-1. However, Mr of the FR-1 receptor is distinctively larger than that of the Spl betaL subunit.

75 FR 12564 - Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-16

... Worth Zoo 74 FR 55062; October February 19, 2010 26, 2009. 223400 Earth Promise, doing 74 FR 46222... San 75 FR 427; January 5. February 26, 2010 Diego. 2010. 230742 The Phoenix Zoo 74 FR 66675; December February 2, 2010 16, 2009. 231594 Seneca Park Zoo 74 FR 58977; November February 2, 2010 16, 2009. 232558...

76 FR 46807 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-03

... collections are mandatory. FR 2030 and FR 2030a: (12 U.S.C. 222, 282, 248(a) and 321). FR 2056: (12 U.S.C. 287, 248(a) and (i)). FR 2086: (12 U.S.C. 287, 248(a) and (i)). FR 2086a: (12 U.S.C. 321, 287, 248(a)). FR... to obtain a benefit (12 U.S.C. 338a, and 12 CFR 208.22). Individual respondent data generally are not...

76 FR 49769 - Proposed Agency Information Collection Activities; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-11

... partner or limited partner, (4) adding event types to the 4(k) schedule, (5) requiring the reporting of...: FR Y-10, FR Y-6, and FR Y-7. OMB control number: 7100-0297. Frequency: FR Y-10: Event-generated; FR Y... an event generated information collection submitted by FBOs; top-tier BHCs; state member banks...

Toward Understanding the Fanaroff-Riley Dichotomy in Radio Source Morphology and Power

NASA Astrophysics Data System (ADS)

Baum, Stefi A.; Zirbel, Esther L.; O'Dea, Christopher P.

1995-09-01

In Paper I we presented the results of a study of the interrelationships between host galaxy magnitude, optical line luminosity, and radio luminosity in a large sample of Fanaroff-Riley classes 1 and 2 (FR 1 and FR 2) radio galaxies. We report several important differences between the FR 1 and FR 2 radio galaxies. At the same host galaxy magnitude or radio luminosity, the FR 2's produce substantially more optical line emission (by roughly an order of magnitude or more) than do FR 1's. Similarly, FR 2 sources produce orders of magnitude more line luminosity than do radio-quiet galaxies of the same optical magnitude, while FR 1 sources and radio-quiet galaxies of the same optical magnitude produce similar line luminosities. Combining these results with previous results from the literature, we conclude that while the emission-line gas in the FR 2's is indeed photoionized by a nuclear UV continuum source from the AGN, the emission-line gas in the FR 1's may be energized predominantly by processes associated with the host galaxy itself. The apparent lack of a strong UV continuum source from the central engine in FR 1 sources can be understood in two different ways. In the first scenario, FR l's are much more efficient at covering jet bulk kinetic energy into radio luminosity than FR 2's, such that an FR 1 has a much lower bolometric AGN luminosity (hence nuclear UV continuum source) than does an FR 2 of the same radio luminosity. We discuss the pros and cons of this model and conclude that the efficiency differences needed between FR 2 and FR 1 radio galaxies are quite large and may lead to difficulties with the interpretation since it would suggest that FR 2 radio source deposit very large amounts of kinetic energy into the ISM Intracluster Medium. However, this interpretation remains viable. Alternatively, it may be that the AGNs in FR 1 sources simply produce far less radiant UV energy than do those in FR 2 sources. That is, FR 1 sources may funnel a higher fraction of the total energy output from the AGNs into jet kinetic energy versus radiant energy than do FR 2 sources. If this interpretation is correct, then this suggests that there is a fundamental difference in the central engine and/or in the immediate "accretion region" around the engine in FR 1 and FR 2 radio galaxies. We note also the absence of FR 1 sources with nuclear broad line regions and suggest that the absence of the BLR is tied to the absence of the "isotropic" nuclear UV continuum source in FR 1 sources. We put forth the possibility that the FR 1/FR 2 dichotomy (i.e., the observed differences in the properties of low- and high-power radio sources) is due to qualitative differences in the structural properties of the central engines in these two types of sources. Following early work by Rees et al. (1982), we suggest the possibility that FR 1 sources are produced when the central engine is fed at a lower accretion rate, leading to the creation of a source in which the ratio of radiant to jet bulk kinetic energy is low, while FR 2 sources are produced when the central engine is fed at a higher accretion rate, causing the central engine to deposit a higher fraction of its energy in radiant energy. We further suggest the possibility that associated differences in the spin properties of the central black hole between FR 1 (lower spin) and FR 2 (higher spin) sources may be responsible for the different collimation properties and Mach numbers of the jets produced by these two types of radio-loud galaxies. This scenario, although currently clearly speculative, is nicely consistent with our current picture of the triggering, feeding, environments, and evolution of powerful radio galaxies. This model allows for evolution of these properties with time for example, the mass accretion rate and BH spin may decline with time causing an FR 2 radio source or quasar to evolve into a FR 1 radio source.

78 FR 35766 - North Carolina: Final Authorization of State Hazardous Waste Management Program Revisions

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-14

..., effective March 19, 1991 (56 FR 1929); April 10, 1991, effective June 9, 1991 (56 FR 14474); July 19, 1991, effective September 17, 1991 (56 FR 33206); April 27, 1992, effective June 26, 1992 (57 FR 15254); December... Significantly Affect Energy Supply, Distribution, or Use'' (66 FR 28355, May 22, 2001) because it is not a...

75 FR 55580 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-13

... authority of the extension for three years, without revision, of the following reports: 1. Report title...: FR 1373a survey, one or two times per year; FR 1373a discussion groups, two times a year. FR 1373b small-panel survey, two times a year; FR 1373b large-panel survey, one time per year. Reporters: FR...

38 CFR 3.54 - Marriage dates.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) Indian wars—March 4, 1917. (iii) Spanish-American War—January 1, 1938. (iv) Mexican border period and... marriage has been met. (Authority: 38 U.S.C. 103(b)) [26 FR 1567, Feb. 24, 1961, as amended at 27 FR 6498... FR 18300, May 3, 1976; 44 FR 22718, Apr. 17, 1979; 54 FR 31829, Aug. 2, 1989; 56 FR 5756, Feb. 13...

Critical Habitat :: NOAA Fisheries

Science.gov Websites

82 FR 51186 (comments close 1/02/18) Beluga Whale Cook Inlet 2011 76 FR 20180 Go to Data Hawaiian Monk Seal 1988, 1986, 2015 53 FR 18988, 51 FR 16047, 80 FR 50925 Go to Data [zip] (excluded areas Revise (Feb 2015) 2006 71 FR 69054 Go To Data [zip] North Atlantic Right Whale Northeast Southeast 1994

49 CFR 172.502 - Prohibited and permissive placarding.

Code of Federal Regulations, 2011 CFR

2011-10-01

... apply until October 1, 2001 to a safety sign or safety slogan (e.g., “Drive Safely” or “Drive Carefully..., 55 FR 52599, Dec. 21, 1990, as amended at 56 FR 66259, Dec. 20, 1991; Amdt. 172-151, 62 FR 1230, Jan. 8, 1997; 62 FR 39389 and 39407, July 22, 1997; 66 FR 8647, Feb. 1, 2001; 66 FR 33426, June 21, 2001...

76 FR 7091 - Notice of Intent To Require Reporting Forms for Savings and Loan Holding Companies

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-08

... title: Financial Statements for Bank Holding Companies. Agency form number: FR Y-9C, FR Y-9LP, FR Y-9SP... financial statements for the consolidated BHC and the parent holding company only. The FR Y-9 family of... condition to ensure safe and sound operations. The FR Y-9C consists of standardized financial statements...

49 CFR Appendix B to Subchapter B... - Special Agents

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 5 2010-10-01 2010-10-01 false Special Agents B Appendix B to Subchapter B of... and 31503; and 49 CFR 1.73) [35 FR 1016, Jan. 24, 1970 as amended at 36 FR 16067, Aug. 19, 1971; 43 FR 20011, May 10, 1978; 44 FR 46425, July 10, 1980; 49 FR 38290, Sept. 28, 1984; 60 FR 38749, July 28, 1995...

49 CFR Appendix B to Subchapter B... - Special Agents

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 5 2011-10-01 2011-10-01 false Special Agents B Appendix B to Subchapter B of... and 31503; and 49 CFR 1.73) [35 FR 1016, Jan. 24, 1970 as amended at 36 FR 16067, Aug. 19, 1971; 43 FR 20011, May 10, 1978; 44 FR 46425, July 10, 1980; 49 FR 38290, Sept. 28, 1984; 60 FR 38749, July 28, 1995...

76 FR 44613 - Notice of Buy American Waiver Under the American Recovery and Reinvestment Act of 2009

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-26

... the bow thruster [75 FR 9256 (March 1, 2010)], anti-roll tank control system [76 FR 184 (January 3, 2011)], weather fax [76 FR 186 (January 3, 2011)], ultrasonic antifouling system [76 FR 35920 (June 20, 2011)], and HVAC generators [76 FR 35919 (June 20, 2011)]; all of which were in excess of this $10,000...

47 CFR 0.31 - Functions of the Office.

Code of Federal Regulations, 2012 CFR

2012-10-01

... other general inquiries by consumers. (Secs. 2, 3, 4, 5, 301, 303, 307, 308, 309, 315, 317, 48 Stat., as..., 301, 303, 307, 308, 309, 315, 317) [45 FR 28718, Apr. 30, 1980, as amended at 46 FR 45342, Sept. 11..., July 13, 1998; 64 FR 60716, Nov. 8, 1999; 67 FR 13217, Mar. 21, 2002; 68 FR 11747, Mar. 12, 2003; 69 FR...

47 CFR 0.31 - Functions of the Office.

Code of Federal Regulations, 2013 CFR

2013-10-01

... other general inquiries by consumers. (Secs. 2, 3, 4, 5, 301, 303, 307, 308, 309, 315, 317, 48 Stat., as..., 301, 303, 307, 308, 309, 315, 317) [45 FR 28718, Apr. 30, 1980, as amended at 46 FR 45342, Sept. 11..., July 13, 1998; 64 FR 60716, Nov. 8, 1999; 67 FR 13217, Mar. 21, 2002; 68 FR 11747, Mar. 12, 2003; 69 FR...

47 CFR 0.31 - Functions of the Office.

Code of Federal Regulations, 2014 CFR

2014-10-01

... other general inquiries by consumers. (Secs. 2, 3, 4, 5, 301, 303, 307, 308, 309, 315, 317, 48 Stat., as..., 301, 303, 307, 308, 309, 315, 317) [45 FR 28718, Apr. 30, 1980, as amended at 46 FR 45342, Sept. 11..., July 13, 1998; 64 FR 60716, Nov. 8, 1999; 67 FR 13217, Mar. 21, 2002; 68 FR 11747, Mar. 12, 2003; 69 FR...

Food restriction affects Y-maze spatial recognition memory in developing mice.

PubMed

Fu, Yu; Chen, Yanmei; Li, Liane; Wang, Yumei; Kong, Xiangyang; Wang, Jianhong

2017-08-01

The ambiguous effects of food restriction (FR) on cognition in rodents have been mostly explored in the aged brain by a variety of paradigms, in which either rewards or punishments are involved. This study aims to examine the effects of chronic and acute FR with varying intensities on spatial recognition memory in developing mice. We have used a Y-maze task that is based on the innate tendency of rodents to explore novel environments. In chronic FR, mice had 70-30% chow of control for seven weeks. In acute FR, mice were food restricted for 12-48h before the tests. We found that chronic FR had no effect on the preference of mice for novelty in the Y-maze, but severe FR (50-30% of control) caused impairment on spatial recognition memory. The impairment significantly correlated with the slow weight growth induced by FR. Acute FR also did not affect the novelty preference of mice, but either improved or impaired the memory retention. These data suggest chronic FR impairs Y-maze spatial recognition memory in developing mice depending on FR intensity and individual tolerability of the FR. Moreover, acute FR exerts diverse effects on the memory, either positive or negative. Our findings have revealed new insights on the effects of FR on spatial recognition memory in developing animals. Copyright © 2017 ISDN. Published by Elsevier Ltd. All rights reserved.

76 FR 41698 - Approval and Promulgation of Air Quality Implementation Plans; New Mexico; Section 110(a)(2...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-15

.../30/1995 9/26/1997, 62 FR 50514 Part 11 Asphalt Process 11/30/1995 9/26/1997, 62 FR 50514 Equipment..., 62 FR 50514 Equipment-Sulfur Dioxide. Part 32 Coal Burning 11/30/1995 9/26/1997, 62 FR 50514... Sulfuric Acid 11/30/1995 9/26/1997, 62 FR 50514 Production Units- Sulfur Dioxide, Acid Mist and Visible...

7 CFR 29.1044 - Orange Red (FR).

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Orange Red (FR). 29.1044 Section 29.1044 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1044 Orange Red (FR). A yellowish red. [42 FR 21092, Apr. 25, 1977. Redesignated at 47 FR...

47 CFR 36.621 - Study area total unseparated loop cost.

Code of Federal Regulations, 2010 CFR

2010-10-01

... support payments beginning July 1, 2001, shall be limited to the lesser of: (i) The actual average monthly..., as amended at 56 FR 27422, June 14, 1991; 62 FR 32948, June 17, 1997; 62 FR 40748, July 30, 1997; 63 FR 2124, Jan. 13, 1998; 66 FR 30086, June 5, 2001] ...

76 FR 18536 - Agency Information Collection Activities Under OMB Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-04

... soliciting comments on this collection of information was published on January 11, 2011. 76 FR 1603. \\2... FR 1603, 1604. \\5\\ See CFTC NPRM: End-User Exception to Mandatory Clearing of Swaps, 75 FR 80747... FR 1603, 1604. The estimated average hourly burden was estimated at .5 hours. Burden Statement: The...

76 FR 13188 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-10

...: Cynthia Ayouch, Acting Federal Reserve Board Clearance Officer (202-452-3829), Division of Research and... Systems Surveys: Ad Hoc Payments Systems Survey, Currency Quality Sampling Survey, Currency Quality Survey, and Currency Functionality Survey. Agency form number: FR 3054a, FR 3054b, FR 3054c, and FR 3054d. OMB...

76 FR 14812 - Final Regulation Extending the Reporting Deadline for Year 2010 Data Elements Required Under the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-18

.... Suppliers of Natural Gas and 221210 Natural gas Natural Gas Liquids. distribution facilities. 211112 Natural gas liquid extraction facilities. Suppliers of Industrial 325120 Industrial gas Greenhouse Gases..., 75 FR Natural Gas Liquids. 66434, 75 FR 79092. Suppliers of Industrial OO 74 FR 56260, 75 FR...

The ratio of red light to far red light alters Arabidopsis axillary bud growth and abscisic acid signalling before stem auxin changes.

PubMed

Holalu, Srinidhi V; Finlayson, Scott A

2017-02-01

Arabidopsis thaliana shoot branching is inhibited by a low red light to far red light ratio (R:FR, an indicator of competition), and by loss of phytochrome B function. Prior studies have shown that phytochrome B deficiency suppresses bud growth by elevating systemic auxin signalling, and that increasing the R:FR promotes the growth of buds suppressed by low R:FR by inhibiting bud abscisic acid (ABA) accumulation and signalling. Here, systemic auxin signalling and bud ABA signalling were examined in the context of rapid bud responses to an increased R:FR. Increasing the R:FR promoted the growth of buds inhibited by a low R:FR within 6 h. Relative to a low R:FR, bud ABA accumulation and signalling in plants given a high R:FR showed a sustained decline within 3 h, prior to increased growth. Main stem auxin levels and signalling showed a weak, transient response. Systemic effects and those localised to the bud were further examined by decapitating plants maintained either under a low R:FR or provided with a high R:FR. Increasing the R:FR promoted bud growth before decapitation, but decapitated plants eventually formed longer branches. The data suggest that rapid responses to an increased R:FR may be mediated by changes in bud ABA physiology, although systemic auxin signalling is necessary for sustained bud repression under a low R:FR. © The Author 2017. Published by Oxford University Press on behalf of the Society for Experimental Biology.

40 CFR 52.2381 - EPA-approved Vermont State regulations.

Code of Federal Regulations, 2012 CFR

2012-07-01

...-fired boilers. 3/24/79 1/30/80 45 FR 6781 (c)(9) Related to PSD. 11/4/79 2/19/80 45 FR 10775 (c)(10) All... FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For NSR Plan. Section 5-406Required air modeling 3/24/79 1/30/80 45 FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For...

40 CFR 52.2381 - EPA-approved Vermont State regulations.

Code of Federal Regulations, 2010 CFR

2010-07-01

...-fired boilers. 3/24/79 1/30/80 45 FR 6781 (c)(9) Related to PSD. 11/4/79 2/19/80 45 FR 10775 (c)(10) All... FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For NSR Plan. Section 5-406Required air modeling 3/24/79 1/30/80 45 FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For...

40 CFR 52.2381 - EPA-approved Vermont State regulations.

Code of Federal Regulations, 2014 CFR

2014-07-01

...-fired boilers. 3/24/79 1/30/80 45 FR 6781 (c)(9) Related to PSD. 11/4/79 2/19/80 45 FR 10775 (c)(10) All... FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For NSR Plan. Section 5-406Required air modeling 3/24/79 1/30/80 45 FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For...

40 CFR 52.2381 - EPA-approved Vermont State regulations.

Code of Federal Regulations, 2013 CFR

2013-07-01

...-fired boilers. 3/24/79 1/30/80 45 FR 6781 (c)(9) Related to PSD. 11/4/79 2/19/80 45 FR 10775 (c)(10) All... FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For NSR Plan. Section 5-406Required air modeling 3/24/79 1/30/80 45 FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For...

40 CFR 52.2381 - EPA-approved Vermont State regulations.

Code of Federal Regulations, 2011 CFR

2011-07-01

...-fired boilers. 3/24/79 1/30/80 45 FR 6781 (c)(9) Related to PSD. 11/4/79 2/19/80 45 FR 10775 (c)(10) All... FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For NSR Plan. Section 5-406Required air modeling 3/24/79 1/30/80 45 FR 6781 (c)(9) For PSD Plan. 3/24/79 2/19/80 45 FR 10775 (c)(10) For...

FR0CAT: a FIRST catalog of FR 0 radio galaxies

NASA Astrophysics Data System (ADS)

Baldi, R. D.; Capetti, A.; Massaro, F.

2018-01-01

With the aim of exploring the properties of the class of FR 0 radio galaxies, we selected a sample of 108 compact radio sources, called FR0CAT, by combining observations from the NVSS, FIRST, and SDSS surveys. We included in the catalog sources with redshift ≤0.05, with a radio size ≲5 kpc, and with an optical spectrum characteristic of low-excitation galaxies. Their radio luminosities at 1.4 GHz are in the range 1038 ≲ νL1.4 ≲ 1040 erg s-1. The FR0CAT hosts are mostly (86%) luminous (-21 ≳ Mr ≳ -23) red early-type galaxies with black hole masses 108 ≲ MBH ≲ 109M⊙. These properties are similar to those seen for the hosts of FR I radio galaxies, but they are on average a factor 1.6 less massive. The number density of FR0CAT sources is 5 times higher than that of FR Is, and thus they represent the dominant population of radio sources in the local Universe. Different scenarios are considered to account for the smaller sizes and larger abundance of FR 0s with respect to FR Is. An age-size scenario that considers FR 0s as young radio galaxies that will all eventually evolve into extended radio sources cannot be reconciled with the large space density of FR 0s. However, the radio activity recurrence, with the duration of the active phase covering a wide range of values and with short active periods strongly favored with respect to longer ones, might account for their large density number. Alternatively, the jet properties of FR 0s might be intrinsically different from those of the FR Is, the former class having lower bulk Lorentz factors, possibly due to lower black hole spins. Our study indicates that FR 0s and FR I/IIs can be interpreted as two extremes of a continuous population of radio sources that is characterized by a broad distribution of sizes and luminosities of their extended radio emission, but shares a single class of host galaxies.

76 FR 65653 - New Source Performance Standards (NSPS) Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-24

..., PM 2.5 , PM 10 ), nitrogen oxides (NO X ), carbon monoxide (CO), lead (Pb), volatile organic... Refineries Ja 06/24/2008 (73FR35867) 12/22/2008 \\4\\ (73FR78552) (Stay) Phosphate Fertilizers--Diammonium V 08/06/1975 (40FR33155) 10/17/2000 3 4 (65FR61757) Phosphate Plants. Phosphate Fertilizers--Granular X 08...

77 FR 3495 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-24

... FR 12255, March 15, April 28, 2010. 2010. 09145A Zoological Society of 75 FR 27814, May 18, June 24, 2010. San Diego. 2010. 13802A Zoological Society of 75 FR 34766, June 18, July 28, 2010. San Diego... 15, 2011. Marine Science Center. 2011. 008519 Zoo Atlanta 75 FR 82409, December March 1, 2011. 30...

75 FR 66762 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-29

... and Salary Surveys. Agency form number: FR 29a,b. OMB control number: 7100-0290. Frequency: FR 29a... independence to determine its employees' salaries and compensation. Individual respondent data are regarded as... jointly. The FR 29b is collected by Board staff. The FR 29a,b collect information on salaries, employee...

78 FR 48712 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-09

... 78 FR 9725; February 11, June 14, 2013. the University of 2013. Illinois. 675484 Birmingham Zoo, Inc..... 78 FR 16292; March 14, May 1, 2013. 2013. 036218 Brevard Zoo 78 FR 1771; March 22, May 1, 2013. 2013... 1771; March 22, May 1, 2013. 2013. 678968 Mesker Park Zoo......... 78 FR 1771; March 22, May 1, 2013...

77 FR 26777 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-07

.... 47878A Nicole Smolensky... 76 FR 57757; November 15, 2011. September 16, 2011. 56912A Nashville Zoo...... 76 FR 72434; March 12, 2012. November 23, 2011. 50819A San Diego Zoo 76 FR 77006; March 12, 2012.... Ranch. 17, 2012. 697763 Houston Zoo, Inc... 77 FR 2314; January March 9, 2012. 17, 2012. 62113A...

77 FR 300 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-04

... Angeles Zoo and 76 FR 60862; September November 23, 2011. Botanical Gardens. 30, 2011. 56760A Los Angeles Zoo and 76 FR 66954; October December 1, 2011. Botanical Gardens. 28, 2011. 57442A Matthew Bindon 76 FR 66954; October December 5, 2011. 28, 2011. 54123A Maryland Zoo in 76 FR 71069; November December...

40 CFR 302.6 - Notification requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... RQ of solid particles of antimony, arsenic, beryllium, cadmium, chromium, copper, lead, nickel.... 14, 1989; 63 FR 13475, Mar. 19, 1998; 63 FR 42189, Aug. 6, 1998; 64 FR 13114, Mar. 17, 1999; 65 FR...

40 CFR 302.6 - Notification requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... RQ of solid particles of antimony, arsenic, beryllium, cadmium, chromium, copper, lead, nickel.... 14, 1989; 63 FR 13475, Mar. 19, 1998; 63 FR 42189, Aug. 6, 1998; 64 FR 13114, Mar. 17, 1999; 65 FR...

40 CFR 302.6 - Notification requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... RQ of solid particles of antimony, arsenic, beryllium, cadmium, chromium, copper, lead, nickel.... 14, 1989; 63 FR 13475, Mar. 19, 1998; 63 FR 42189, Aug. 6, 1998; 64 FR 13114, Mar. 17, 1999; 65 FR...

Endoscopic ultrasound-guided biliary drainage using a newly designed metal stent with a thin delivery system: a preclinical study in phantom and porcine models.

PubMed

Minaga, Kosuke; Kitano, Masayuki; Itonaga, Masahiro; Imai, Hajime; Miyata, Takeshi; Yamao, Kentaro; Tamura, Takashi; Nuta, Junya; Warigaya, Kenji; Kudo, Masatoshi

2017-12-08

This study was designed to evaluate the feasibility and safety of a newly designed self-expandable metal stent for endoscopic ultrasound-guided biliary drainage (EUS-BD) when it was delivered via three different stent delivery systems: a 7.5Fr delivery catheter with a bullet-shaped tip (7.5Fr-bullet), a 7Fr catheter with a bullet-shaped tip (7Fr-bullet), or a 7Fr catheter with a tee-shaped tip (7Fr-tee). This experimental study utilized a porcine model of biliary dilatation involving ten pigs. In the animal study, technical feasibility and clinical outcomes of the stent when placed with each of the delivery systems were examined. In addition, a phantom model was used to measure the resistance of these delivery systems to advancement. Phantom experiments showed that, compared with 7Fr-bullet, 7Fr-tee had less resistance force to the advancement of the stent delivery system. EUS-BD was technically successful in all ten pigs. Fistulous tract dilation was necessary in 100% (2/2), 75% (3/4), and 0% (0/4) of the pigs that underwent EUS-BD using 7.5Fr-bullet, 7Fr-bullet, and 7Fr-tee, respectively. There were no procedure-related complications. Our newly designed metal stent may be feasible and safe for EUS-BD, particularly when delivered by 7Fr-tee, because it eliminates the need for fistulous tract dilation.

Stimulatory Effect of Food Restriction on the Steroidogenesis of Aldosterone in Ovariectomized Rats.

PubMed

Kau, Mei-Mei; Yu, Ching-Han; Tsai, Shiow-Chwen; Wang, Jiing-Rong; Wang, Paulus S.

2017-04-30

Food or calorie restriction (FR or CR) induces several physiological changes including weight loss, metabolic adaptations, mineral and hormonal changes. However, the effects of FR on aldosterone steroidogenesis in zona glomerulosa (ZG) cells have not been elucidated. Therefore, the present study was designed to investigate the effects of FR on aldosterone secretion and the involved mechanisms in ovariectomized (Ovx) rats. Ovx rats were divided into ad libitum fed (control) and FR groups. The FR rats exhibited decreased body weight, water intake, urine flow, sodium excretion and increased plasma aldosterone in comparison with control rats. FR elevated the basal and angiotensin II-stimulated aldosterone secretion from ZG cells. The conversions of 25-hydroxy-cholesterol to pregnenolone or corticosterone to aldosterone in ZG cells of FR group were greater than that in control group. FR group had a higher protein expression of steroidogenic acute regulatory (StAR) protein in ZG cells. However, there was no different protein expression of cytochrome P450 sidechain cleavage enzyme (P450scc) in ZG cells between control and FR groups. In summary, the increased activities of P450scc and aldosterone synthase as well as the protein expression of StAR protein in ZG cells are involved in the effects of FR on aldosterone steroidogenesis in Ovx rats. We also suggest that the increase of aldosterone might be associated with anti-diuresis and antinatriuresis in FR group. These results are helpful for understanding the role of aldosterone in physiological adaptation and renal sodium conservation during FR.

Facilitation of the flexor reflex in the cat by intrathecal injection of catecholamines

PubMed Central

Dhawan, B. N.; Sharma, J. N.

1970-01-01

1. Effects of some α- and β-adrenoceptor stimulants and antagonists were investigated on flexor reflex (FR) in chloralosed cats. 2. Noradrenaline (NA) produced facilitation of FR which was dose-dependent and reproducible and was blocked by α-adrenoceptor blocking agents. 3. Strychnine also produced facilitation of FR but the response was unaffected by α-adrenoceptor blocking agents. 4. Metaraminol and α-methyl-noradrenaline had little effect on FR but blocked the NA response. 5. β-adrenoceptor stimulants and antagonists had neither any effect on FR nor modified the NA response. 6. Vasopressin and histamine also failed to modify FR. 7. Possibility of α-adrenoceptors in the neurones integrating FR is suggested. PMID:4395376

40 CFR 61.01 - Lists of pollutants and applicability of part 61.

Code of Federal Regulations, 2012 CFR

2012-07-01

...; June 10, 1985) Methylene Chloride (50 FR 42037; Oct. 17, 1985) Nickel (51 FR 34135; Sept. 25, 1986... Chloride (40 FR 59532; Dec. 24, 1975) (b) The following list presents other substances for which a Federal...) Vinylidene Chloride (50 FR 32632; Aug. 13, 1985) Zinc and Zinc Oxide (52 FR 32597, Aug. 28, 1987) (c) This...

40 CFR 61.01 - Lists of pollutants and applicability of part 61.

Code of Federal Regulations, 2013 CFR

2013-07-01

...; June 10, 1985) Methylene Chloride (50 FR 42037; Oct. 17, 1985) Nickel (51 FR 34135; Sept. 25, 1986... Chloride (40 FR 59532; Dec. 24, 1975) (b) The following list presents other substances for which a Federal...) Vinylidene Chloride (50 FR 32632; Aug. 13, 1985) Zinc and Zinc Oxide (52 FR 32597, Aug. 28, 1987) (c) This...

40 CFR 61.01 - Lists of pollutants and applicability of part 61.

Code of Federal Regulations, 2014 CFR

2014-07-01

...; June 10, 1985) Methylene Chloride (50 FR 42037; Oct. 17, 1985) Nickel (51 FR 34135; Sept. 25, 1986... Chloride (40 FR 59532; Dec. 24, 1975) (b) The following list presents other substances for which a Federal...) Vinylidene Chloride (50 FR 32632; Aug. 13, 1985) Zinc and Zinc Oxide (52 FR 32597, Aug. 28, 1987) (c) This...

77 FR 17477 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-26

..., revised, or implemented on or after October 1, 1995, unless it displays a currently valid OMB control... Building, Room 10235, 725 17th Street NW., Washington, DC 20503. Final approval under OMB delegated... response: FR 2028A, 3.6 hours; FR 2028B, 1.4 hours; and FR 2028S, 0.1 hours. Number of respondents: FR...

47 CFR 0.41 - Functions of the Office.

Code of Federal Regulations, 2011 CFR

2011-10-01

... from the public and others. (Secs. 2, 3, 4, 5, 301, 303, 307, 308, 309, 315, 317, 48 Stat., as amended..., 303, 307, 308, 309, 315, 317) [28 FR 12392, Nov. 22, 1963; 37 FR 19372, Sept. 20, 1972, as amended at...; 62 FR 15853, Apr. 3, 1997; 64 FR 5950, Feb. 8, 1999; 64 FR 57585, Oct. 26, 1999] International Bureau ...

47 CFR 0.41 - Functions of the Office.

Code of Federal Regulations, 2013 CFR

2013-10-01

... from the public and others. (Secs. 2, 3, 4, 5, 301, 303, 307, 308, 309, 315, 317, 48 Stat., as amended..., 303, 307, 308, 309, 315, 317) [28 FR 12392, Nov. 22, 1963; 37 FR 19372, Sept. 20, 1972, as amended at...; 62 FR 15853, Apr. 3, 1997; 64 FR 5950, Feb. 8, 1999; 64 FR 57585, Oct. 26, 1999] International Bureau ...

47 CFR 0.41 - Functions of the Office.

Code of Federal Regulations, 2012 CFR

2012-10-01

... from the public and others. (Secs. 2, 3, 4, 5, 301, 303, 307, 308, 309, 315, 317, 48 Stat., as amended..., 303, 307, 308, 309, 315, 317) [28 FR 12392, Nov. 22, 1963; 37 FR 19372, Sept. 20, 1972, as amended at...; 62 FR 15853, Apr. 3, 1997; 64 FR 5950, Feb. 8, 1999; 64 FR 57585, Oct. 26, 1999] International Bureau ...

47 CFR 0.41 - Functions of the Office.

Code of Federal Regulations, 2014 CFR

2014-10-01

... from the public and others. (Secs. 2, 3, 4, 5, 301, 303, 307, 308, 309, 315, 317, 48 Stat., as amended..., 303, 307, 308, 309, 315, 317) [28 FR 12392, Nov. 22, 1963; 37 FR 19372, Sept. 20, 1972, as amended at...; 62 FR 15853, Apr. 3, 1997; 64 FR 5950, Feb. 8, 1999; 64 FR 57585, Oct. 26, 1999] International Bureau ...

7 CFR 301.53-3 - Quarantined areas.

Code of Federal Regulations, 2013 CFR

2013-01-01

..., Alpena, Antrim, Arenac, Barry, Bay, Benzie, Berrien, Branch, Calhoun, Cass, Charlevoix, Cheboygan, Clare.... 3, 2005; 70 FR 62231, Oct. 31, 2005; 71 FR 29764, May 24, 2006; 71 FR 57873, Oct. 2, 2006; 72 FR...

7 CFR 301.53-3 - Quarantined areas.

Code of Federal Regulations, 2012 CFR

2012-01-01

..., Alpena, Antrim, Arenac, Barry, Bay, Benzie, Berrien, Branch, Calhoun, Cass, Charlevoix, Cheboygan, Clare.... 3, 2005; 70 FR 62231, Oct. 31, 2005; 71 FR 29764, May 24, 2006; 71 FR 57873, Oct. 2, 2006; 72 FR...

7 CFR 301.53-3 - Quarantined areas.

Code of Federal Regulations, 2011 CFR

2011-01-01

..., Alpena, Antrim, Arenac, Barry, Bay, Benzie, Berrien, Branch, Calhoun, Cass, Charlevoix, Cheboygan, Clare.... 3, 2005; 70 FR 62231, Oct. 31, 2005; 71 FR 29764, May 24, 2006; 71 FR 57873, Oct. 2, 2006; 72 FR...

7 CFR 301.53-3 - Quarantined areas.

Code of Federal Regulations, 2014 CFR

2014-01-01

..., Alpena, Antrim, Arenac, Barry, Bay, Benzie, Berrien, Branch, Calhoun, Cass, Charlevoix, Cheboygan, Clare.... 3, 2005; 70 FR 62231, Oct. 31, 2005; 71 FR 29764, May 24, 2006; 71 FR 57873, Oct. 2, 2006; 72 FR...

Large-scale magnetic topologies of mid M dwarfs

NASA Astrophysics Data System (ADS)

Morin, J.; Donati, J.-F.; Petit, P.; Delfosse, X.; Forveille, T.; Albert, L.; Aurière, M.; Cabanac, R.; Dintrans, B.; Fares, R.; Gastine, T.; Jardine, M. M.; Lignières, F.; Paletou, F.; Ramirez Velez, J. C.; Théado, S.

2008-10-01

We present in this paper, the first results of a spectropolarimetric analysis of a small sample (~20) of active stars ranging from spectral type M0 to M8, which are either fully convective or possess a very small radiative core. This study aims at providing new constraints on dynamo processes in fully convective stars. This paper focuses on five stars of spectral type ~M4, i.e. with masses close to the full convection threshold (~=0.35Msolar), and with short rotational periods. Tomographic imaging techniques allow us to reconstruct the surface magnetic topologies from the rotationally modulated time-series of circularly polarized profiles. We find that all stars host mainly axisymmetric large-scale poloidal fields. Three stars were observed at two different epochs separated by ~1 yr; we find the magnetic topologies to be globally stable on this time-scale. We also provide an accurate estimation of the rotational period of all stars, thus allowing us to start studying how rotation impacts the large-scale magnetic field. Based on observations obtained at the Canada-France-Hawaii Telescope (CFHT) and the Télescope Bernard Lyot (TBL). CFHT is operated by the National Research Council of Canada, the Institut National des Science de l'Univers of the Centre National de la Recherche Scientifique of France (INSU/CNRS) and the University of Hawaii, while the TBL is operated by CNRS/INSU. E-mail: jmorin@ast.obs-mip.fr (JM); donati@ast.obs-mip.fr (J-FD); petit@ast.obs-mip.fr (PP); xavier.delfosse@obs.ujf-grenoble.fr (XD); thierry.forveille@obs.ujf-grenoble.fr (TF); albert@cfht.hawaii.edu (LA); auriere@ast.obs-mip.fr (MA); remi.cabanac@ast.obs-mip.fr (RC); dintrans@ast.obs-mip.fr (BD); rfares@ast.obs-mip.fr (RF); tgastine@ast.obs-mip.fr (TG); mmj@st-andrews.ac.uk (MMJ); ligniere@ast.obs-mip.fr (FL); fpaletou@ast.obs-mip.fr (FP); jramirez@mesiog.obspm.fr (JR); sylvie.theado@ast.obs-mip.fr (ST)

40 CFR 52.2120 - Identification of plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

... II Sulfuric Acid Manufacturing 2/28/1986 2/17/1987 52 FR 4772 Section III Kraft Pulp and Paper.../1987 52 FR 4772 Section V Cotton Gins 10/26/2001 5/7/2002 67 FR 30594 Section VI Hot Mix Asphalt.../1990 2/4/1992 57 FR 4158 Part C Surface Coating of Paper, Vinyl, and Fabric 8/24/1990 2/4/1992 57 FR...

40 CFR 52.2120 - Identification of plan.

Code of Federal Regulations, 2014 CFR

2014-07-01

... II Sulfuric Acid Manufacturing 2/28/1986 2/17/1987 52 FR 4772 Section III Kraft Pulp and Paper.../1987 52 FR 4772 Section V Cotton Gins 10/26/2001 5/7/2002 67 FR 30594 Section VI Hot Mix Asphalt.../1990 2/4/1992 57 FR 4158 Part C Surface Coating of Paper, Vinyl, and Fabric 8/24/1990 2/4/1992 57 FR...

40 CFR 52.2120 - Identification of plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Section II Sulfuric Acid Manufacturing 2/28/1986 2/17/1987 52 FR 4772 Section III Kraft Pulp and Paper.../1987 52 FR 4772 Section V Cotton Gins 10/26/2001 5/7/2002 67 FR 30594 Section VI Hot Mix Asphalt.../1990 2/4/1992 57 FR 4158 Part C Surface Coating of Paper, Vinyl, and Fabric 8/24/1990 2/4/1992 57 FR...

11 CFR 102.2 - Statement of organization: Forms and committee identification number (2 U.S.C. 433 (b), (c)).

Code of Federal Regulations, 2010 CFR

2010-01-01

... boxes, or other depositories used by the committee; (vii) The Internet address of the committee's... on all communications concerning reports and statements. [45 FR 15104, Mar. 7, 1980, as amended at 50 FR 50778, Dec. 12, 1985; 54 FR 34109, Aug. 17, 1989; 54 FR 48580, Nov. 24, 1989; 58 FR 42173, Aug. 6...

40 CFR 52.520 - Identification of plan.

Code of Federal Regulations, 2014 CFR

2014-07-01

... FR 52916 62-210.700 Excess Emissions 11/23/94 6/16/9964 FR 32346 62-210.900 Forms and Instructions 2/9/93 11/7/9459 FR 46157 62-210.920 Air General Permit Forms 5/9/2007 6/1/200963 FR 26103 Chapter 62... 13883 62-252.900 Form 2/2/93 7/21/9762 FR 38918 Chapter 62-256 Open Burning and Frost Protection Fires...

78 FR 33860 - Workforce Investment Act of 1998 (WIA); Notice of Incentive Funding Availability Based on Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-05

... Administration published a document in the Federal Register of May 24, 2013, notifying eligible state grantees of... Murren, 202-693-3733. Corrections In the Federal Register of May 24, 2013, in FR Doc. 78 FR 31596, on...''. In the Federal Register of May 24, 2013, in FR Doc. 78 FR 31596, on page 31597, in the first column...

An RGDS peptide-binding receptor, FR-1R, localizes to the basal side of the ectoderm and to primary mesenchyme cells in sand dollar embryos.

PubMed

Katow, H; Sofuku, S

2001-10-01

Immunoblotting using polyclonal antibodies (pAb) raised against an FR-1 receptor (FR-1R), a 57 kDa Arg-Gly-Asp-Ser (RGDS)-binding protein, of the sand dollar Clypeaster japonicus showed that the pAb monospecifically bound to the protein. FR-1R was present in purified plasma membrane, suggesting that the protein is a membrane-bound protein. The molecular structure of FR-1R did not change throughout the early embryogenesis, whereas its expression changed significantly during this period. FR-1R was present in the cortex of unfertilized eggs and was then transferred to the hyaline layer soon after the fertilization. The hyaline layer retained FR-1R immunoreactivity during early embryogenesis. FR-1R appeared on the basal side of the ectoderm at the morula stage and was retained basolaterally, at least, to the early gastrula stage. In mesenchyme blastulae, FR-1R was also present on the surface of primary mesenchyme cells (PMC). FR-1R was localized on the basal side of the ectoderm in early gastrulae, exclusively at the place where PMC formed ventrolateral aggregates, and at the apical tuft ectoderm. In vitro, PMC bound to FR-1R and its binding was inhibited in the presence of a synthetic RGDS peptide or the pAb. The pAb introduced into the blastocoele perturbed PMC migration and gastrulation. FR-1R was weakly recognized by antihuman integrin beta5 subunit pAb.

76 FR 32222 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-03

... Zoological Society of 76 FR 2408; January March 10, 2011. San Diego. 13, 2011. 27787A Virginia Aquarium & 76 FR 2408; January February 15, 2011. Marine Science 13, 2011. Center. 26030A Drexel University, 75 FR...

47 CFR 73.681 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

...Hz and 120 kHz to convey information or that encodes digital information in the video portion of the...; 47 FR 35990, Aug. 18, 1982; 49 FR 18106, Apr. 27, 1984; 49 FR 38131, Sept. 27, 1984; 49 FR 50048, Dec...

33 CFR 165.1107 - San Diego Bay, California.

Code of Federal Regulations, 2010 CFR

2010-07-01

...)(1). [CGD11-90-07, 56 FR 14645, Apr. 11, 1991; 56 FR 40360, Aug. 14, 1991, as amended by USCG-1998-3799, 63 FR 35533, June 30, 1998. Redesignated by USCG-2001-9286, 66 FR 33642, June 25, 2001] ...

33 CFR 165.1107 - San Diego Bay, California.

Code of Federal Regulations, 2011 CFR

2011-07-01

...)(1). [CGD11-90-07, 56 FR 14645, Apr. 11, 1991; 56 FR 40360, Aug. 14, 1991, as amended by USCG-1998-3799, 63 FR 35533, June 30, 1998. Redesignated by USCG-2001-9286, 66 FR 33642, June 25, 2001] ...

78 FR 12780 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-25

... Moore 77 FR 66476; January 14, 2013. November 5, 2012. 84872A Palm Beach Zoo at 77FR 66476; November... Islands November 16, 2012. Regional Office. 89103A Dallas Zoo 77FR 68809; November February 12, 2013. 16...

75 FR 17947 - Endangered and Threatened Wildlife and Plants; 5-Year Status Reviews of 69 Species in Idaho...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

..., [Unnamed] Drosophila aglaia...... E U.S.A. (HI) 71 FR 26835; 5/9/2006. Pomace fly, [Unnamed] Drosophila differens... E U.S.A. (HI) 71 FR 26835; 5/9/2006. Pomace fly, [Unnamed] Drosophila hemipeza.... E U.S.A. (HI) 71 FR 26835; 5/9/2006. Pomace fly, [Unnamed] Drosophila heteroneura. E U.S.A. (HI) 71 FR 26835; 5/9...

27 CFR 28.65 - Bond, Form 2738 (5110.68).

Code of Federal Regulations, 2010 CFR

2010-04-01

... as provided in § 28.171(d) and the terms of his bond on Form 2738 (5110.68), then in force, do not..., 5066) [T.D. 7112, 36 FR 8580, May 8, 1971. Redesignated at 40 FR 16835, Apr. 15, 1975, and amended by T.D. ATF-62, 44 FR 71721, Dec. 11, 1979; T.D. ATF-198, 50 FR 8559, Mar. 1, 1985; T.D. TTB-8, 69 FR...

27 CFR 28.65 - Bond, Form 2738 (5110.68).

Code of Federal Regulations, 2011 CFR

2011-04-01

... as provided in § 28.171(d) and the terms of his bond on Form 2738 (5110.68), then in force, do not..., 5066) [T.D. 7112, 36 FR 8580, May 8, 1971. Redesignated at 40 FR 16835, Apr. 15, 1975, and amended by T.D. ATF-62, 44 FR 71721, Dec. 11, 1979; T.D. ATF-198, 50 FR 8559, Mar. 1, 1985; T.D. TTB-8, 69 FR...

40 CFR 52.520 - Identification of plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 52916 62-210.700 Excess Emissions 11/23/94 6/16/9964 FR 32346 62-210.900 Forms and Instructions 2/9/93 11/7/9459 FR 46157 62-210.920 Air General Permit Forms 9/4/2006 06/01/0974 FR 26103 Chapter 62-212... Tanker Trucks 9/4/2006 06/01/0974 FR 26103 62-252.800 Penalties 2/2/93 3/24/9459 FR 13883 62-252.900 Form...

40 CFR 52.520 - Identification of plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Excess Emissions 11/23/94 6/16/9964 FR 32346 62-210.900 Forms and Instructions 2/9/93 11/7/9459 FR 46157 62-210.920 Air General Permit Forms 9/4/2006 06/01/0974 FR 26103 Chapter 62-212 Stationary Souces... 2/2/93 3/24/9459 FR 13883 62-252.900 Form 2/2/93 7/21/9762 FR 38918 Chapter 62-256Open Burning and...

Dirac Quasinormal Modes of Static f(R) de Sitter Black Holes

NASA Astrophysics Data System (ADS)

Ma, Hong

2018-02-01

Quasinormal modes (QNMs) for Dirac perturbations of f(R) black holes (BHs) are described in this paper, involving two types of f(R) solution: f(R) (Schwarzschild) BHs and f(R) (Maxwell) BHs. With the finite difference method, the stability of the f(R) black holes (BHs) is analysed and the threshold range of f(R) (Schwarzschild) BHs and f(R) (Maxwell) BHs is defined respectively. The results show that due to the presence of the correction factor R0, the damping rate of Dirac field decreases. Meanwhile, the influence of angular quantum number values |k| on the f(R) BHs is investigated. The results indicate that the QNMs oscillation becomes tenser and damping speed slowly decreases with |k| increasing. Furthermore, under the Dirac perturbation, the stability of f(R) solutions can be reflected in the manner of Dirac QNMs. The relationships between the QNMs and the parameters (|k|, charge Q and mass m) are discussed in massless, and massive cases, by contrast to the classical BHs. Supported by FAPESP No. 2012/08934-0, National Natural Science Foundation of China under Grant Nos. 11205254, 11178018, 11375279, 11605015, and the Natural Science Foundation Project of CQ CSTC 2011BB0052, and the Fundamental Research Funds for the Central Universities 106112016CDJXY300002 and CDJRC10300003

PREFACE: Nanosafe 2012: International Conferences on Safe Production and Use of Nanomaterials

NASA Astrophysics Data System (ADS)

Tardif, François

2013-04-01

Welcome from the organizers The rapidly developing field of nanotechnology opens up many exciting opportunities and benefits for new materials with significantly improved properties as well as some revolutionary applications in the fields of energy, environment, medicine, etc. These new materials potentially pave the way to considerable innovations in many industries of the 21st century although associated risks must be perfectly under control for workers, consumers and the environment. So, one can easily understand why Nanosafety is now considered as a specific new scientific area, gaining in importance and maturity every day. Following the successful outcome of the two past international conferences on the safe production and use of nanomaterials: Nanosafe 2008 and 2010, the organizing committee has the pleasure of welcoming again to Grenoble some of the most famous specialists of the field in the world. In addition to the standard issues addressed in previous nanosafe conferences such as Toxicology, Eco-toxicology, Expology, Detection, Life Cycle Analysis, Regulation and Standardization, new topics of great interest will be dealt with this year, concerning Governance and practical Risk Management for OSH experts and Societal issues. In order to enhance the exchanges and conviviality three debates werw organized around Nano Governance, Toxicology and Ethics. We hope that you will appreciate this new Nanosafe edition like the previous ones. This is your Nanosafe conference, please enjoy. The Nanosafe conference organisers François Tardif and Frédéric Shuster Management Vanessa Gaultier Francois TardifFrederic ShusterVanessa Gaultier François TardifFrédéric Shuster Vanessa Gaultier Local Organizing Committee Vanessa GAULTIER (CEA) François TARDIF (CEA) Dominique BAGUET (CEA) Frédédric SHUSTER (CEA) Yves SICARD (CEA) Catherine DURAND (CEA) Didier MOLKO (MINATEC) International Scientific Committee Chair: Frédéric SCHUSTER (CEA, FR) François TARDIF (CEA, FR) Co-chair: Georgios KATALAGARIANAKIS (EC, BE) Mélanie AUFFAN (CEREGE, FR) Jorge BOCZKOWSKI (INSERM, FR) Jean-Yves BOTTERO (CEREGE, FR) Jacques BOUILLARD (INERIS, FR) Derk BROUWER (TNO, NL) Marie CARRIERE (CEA, FR) Claude EMOND (U. MONTREAL, CA) Cassandra ENGEMAN (UCSB, USA) Eric GAFFET (CNRS, FR) François GENSDARMES (IRSN, FR) Alexei GRINBAUM (CEA, FR) Antje GROBE (U.STUTTGART, DE) Peter HOET (KUL, BE) Eric QUEMENEUR (CEA, FR) Olivier LE BIHAN (INERIS, FR) Robert MUIR (NANEUM, UK) Tinh NGUYEN (NIST, USA) Bernd NOWACK (EMPA, CH) Günter OBERDÖRSTER (U. ROCHESTER, USA) David PUI (U. MINNESOTA, USA) Michael RIEDIKER (IST, CH) Yves SAMSON (CEA, FR) Ken TAKEDA (U. TOKYO, JP) Olivier WITSCHGER (INRS, FR) The PDF contains a list of sponsor logos, the conference programme and planning documents.

The preventive effect of sensorimotor- and vibration exercises on the onset of Oxaliplatin- or vinca-alkaloid induced peripheral neuropathies - STOP.

PubMed

Streckmann, Fiona; Balke, Maryam; Lehmann, Helmar C; Rustler, Vanessa; Koliamitra, Christina; Elter, Thomas; Hallek, Michael; Leitzmann, Michael; Steinmetz, Tilman; Heinen, Petra; Baumann, Freerk T; Bloch, Wilhelm

2018-01-10

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and clinically relevant side effect of chemotherapy. Approximately 50% of all leukemia, lymphoma, colorectal- and breast cancer patients are affected. CIPN is induced by neurotoxic chemotherapeutic agents and can manifest with sensory and/or motor deficits. It is associated with significant disability and poor recovery. Common symptoms include pain, altered sensation, reduced or absent reflexes, muscle weakness, reduced balance control and insecure gait. These symptoms not only affect activities of daily living, subsequently reducing patients' quality of life, they have far more become a decisive limiting factor for medical therapy, causing treatment delays, dose reductions, or even discontinuation of therapy, which can affect the outcome and compromise survival. To date, CIPN cannot be prevented and its occurrence presents a diagnostic dilemma since approved and effective treatment options are lacking. Promising results have recently been achieved with exercise. We have revealed that sensorimotor training (SMT) or whole body vibration (WBV) can reduce the symptoms of CIPN and attenuate motor and sensory deficits. We furthermore detected a tendency that it may also have a preventive effect on the onset of CIPN. We are therefore conducting a prospective, multicentre, controlled clinical trial involving 236 oncological patients receiving either oxaliplatin (N = 118) or vinca-alkaloid (N = 118) who are randomized to one of two interventions (SMT or WBV) or a treatment as usual (TAU) group. Primary endpoint is the time to incidence of neurologically confirmed CIPN. Secondary endpoints are pain, maintenance of the functionality of sensory as well as motor nerve fibres as well as the level of physical activity. The baseline assessment is performed prior to the first cycle of chemotherapy. Subsequent follow-up assessments are conducted at 12 weeks, after completion of chemotherapy, and at a 3-month follow-up. Patients who develop CIPN receive an additional assessment at this time point, as it represents the primary endpoint. We hypothesize that SMT and WBV prevent the onset or delay the progression of CIPN, decrease the likelihood of dose reductions or discontinuation of cancer treatment and improve patients' quality of life. Deutsche Register Klinischer Studien ( DRKS00006088 , registered 07.05.2014).

Exploring end-of-life interaction in dyads of parents and adult children: a protocol for a mixed-methods study.

PubMed

Stiel, Stephanie; Stelzer, Eva-Maria; Schneider, Nils; Herbst, Franziska A

2018-04-27

A considerable number of terminally-ill adult children are outlived by at least one parent and receive palliative care prior to their death. At the same time, adult children continue to be confronted with their parents' terminal illnesses and end-of-life situations. The current study explores the specifics of dyadic interaction at the end of life between a) adult children suffering from a life-threatening disease and their parents, and b) terminally ill parents and their adult children. This prospective observational study aims at filling the existing gap on adult child-parent interaction specifics at the end of life using an exploratory mixed-methods framework. The mixed-methods framework combines a qualitative face-to face interview and quantitative self-report questionnaires to study the topic at hand. The qualitative interview will focus on experiences, expectations, and wishes with regard to dyadic communication, information about illness and prognosis, expressed and perceived burden and support as well as caregiving role at the end of life. The questionnaires will cover socio-demographics, loneliness, attachment style, social support, and emotional closeness. The research group is currently adjusting a semi-structured interview guide and questionnaire instructions based on the results of a multiprofessional scientific advisory board meeting (Jan. 2018). In a next step, and prior to qualitative and quantitative data collection, the questionnaires will be piloted on patients and their family members in a palliative care setting. The main expected results are i) a description of the specifics of the interaction within and between both dyads, ii) the development of hypotheses and a theoretical framework on the specifics, similarities, and differences for both study groups, and iii) clinical conclusions on specific psychosocial care needs of both groups. The study was registered prospectively in the Health Services Research Germany register (Versorgungsforschung Deutschland - Datenbank) (Registration N° VfD_Dy@EoL_17_003897; date of registration: November 22, 2017) and in the German Clinical Trials Register (Deutsches Register Klinischer Studien) (Registration N° DRKS00013206 ; date of registration: October 27, 2017). The study is visible in the International Clinical Trials Registry Platform Search Portal of the World Health Organization under the German Clinical Trials Register number.

Effects of heart rate variability biofeedback during exposure to fear-provoking stimuli within spider-fearful individuals: study protocol for a randomized controlled trial.

PubMed

Schäfer, Sarah K; Ihmig, Frank R; Lara H, Karen A; Neurohr, Frank; Kiefer, Stephan; Staginnus, Marlene; Lass-Hennemann, Johanna; Michael, Tanja

2018-03-16

Specific phobias are among the most common anxiety disorders. Exposure therapy is the treatment of choice for specific phobias. However, not all patients respond equally well to it. Hence, current research focuses on therapeutic add-ons to increase and consolidate the effects of exposure therapy. One potential therapeutic add-on is biofeedback to increase heart rate variability (HRV). A recent meta-analysis shows beneficial effects of HRV biofeedback interventions on stress and anxiety symptoms. Therefore, the purpose of the current trial is to evaluate the effects of HRV biofeedback, which is practiced before and utilized during exposure, in spider-fearful individuals. Further, this trial is the first to differentiate between the effects of a HRV biofeedback intervention and those of a low-load working memory (WM) task. Eighty spider-fearful individuals participate in the study. All participants receive a training session in which they practice two tasks (HRV biofeedback and a motor pseudo-biofeedback task or two motor pseudo-biofeedback tasks). Afterwards, they train both tasks at home for 6 days. One week later, during the exposure session, they watch 16 1-min spider video clips. Participants are divided into four groups: group 1 practices the HRV biofeedback and one motor pseudo-task before exposure and utilizes HRV biofeedback during exposure. Group 2 receives the same training, but continues the pseudo-biofeedback task during exposure. Group 3 practices two pseudo-biofeedback tasks and continues one of them during exposure. Group 4 trains in two pseudo-biofeedback tasks and has no additional task during exposure. The primary outcome is fear of spiders (measured by the Fear of Spiders Questionnaire and the Behavioral Approach Test). Secondary outcomes are physiological measures based on electrodermal activity, electrocardiogram and respiration. This RCT is the first one to investigate the effects of using a pre-trained HRV biofeedback during exposure in spider-fearful individuals. The study critically contrasts the effects of the biofeedback intervention with those of pseudo-tasks, which also require WM capacity, but which do not have a physiological base. If HRV biofeedback is effective in reducing fear of spiders, it would represent an easy-to-use tool to improve exposure-therapy outcomes. Deutsches Register Klinischer Studien, DRKS00012278 . Registered on 23 May 2017, amendment on 5 October 2017.

Suitability of current definitions of ambulatory care sensitive conditions for research in emergency department patients: a secondary health data analysis.

PubMed

Frick, Johann; Möckel, Martin; Muller, Reinhold; Searle, Julia; Somasundaram, Rajan; Slagman, Anna

2017-10-22

The aim of this study was to investigate the suitability of existing definitions of ambulatory care sensitive conditions (ACSC) in the setting of an emergency department (ED) by assessing ACSC prevalence in patients admitted to hospital after their ED stay. The secondary aim was to identify ACSC suitable for specific application in the ED setting. Observational clinical study with secondary health data. Two EDs of the Charité-Universitätsmedizin Berlin. All medical ED patients of the 'The Charité Emergency Medicine Study' (CHARITEM) study, who were admitted as inpatients during the 1-year study period (n=13 536). Prevalence of ACSC. Prevalence of ACSC in the study population differed significantly depending on the respective ACSC set used. Prevalence ranged between 19.1% (95% CI 18.4% to 19.8%; n=2586) using the definition by Albrecht et al and 36.6% (95% CI 35.8% to 37.5%; n=4960) using the definition of Naumann et al . (p<0.001). Overall ACSC prevalence (ie, when using all diagnoses used in any of the assessed ACSC-definitions) was 48.1% (95% CI 47.2% to 48.9%; n=6505). Some frequently observed diagnoses such as ' convulsion and epilepsy ' (prevalence: 3.4%, 95% CI 3.1% to 3.7%; n=455), ' diseases of the urinary system ' (prevalence: 1.4%; 95% CI 1.2% to 1.6%; n=191) or ' atrial fibrillation and flutter ' (prevalence: 1.0%, 95% CI 0.8% to 1.2%, n=134) are not included in all of the current ACSC definitions. The results highlight the need for an optimised, ED-specific ACSC definition. Particular ACSC diagnoses (such as ' convulsion and epilepsy ' or ' diseases of the urinary system ' and others) seem to be of special relevance in an ED population but are not included in all available ACSC definitions. Further research towards the development of a suitable and specific ACSC definition for research in the ED setting seems warranted. German Clinical Trials Register Deutsches Register für Klinische Studien: DRKS-ID: DRKS00000261. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Interaction between behavioral and pharmacological treatment strategies to decrease cocaine choice in rhesus monkeys.

PubMed

Banks, Matthew L; Blough, Bruce E; Negus, S Stevens

2013-02-01

Behavioral and pharmacotherapeutic approaches constitute two prominent strategies for treating cocaine dependence. This study investigated interactions between behavioral and pharmacological strategies in a preclinical model of cocaine vs food choice. Six rhesus monkeys, implanted with a chronic indwelling double-lumen venous catheter, initially responded under a concurrent schedule of food delivery (1-g pellets, fixed-ratio (FR) 100 schedule) and cocaine injections (0-0.1 mg/kg/injection, FR 10 schedule) during continuous 7-day treatment periods with saline or the agonist medication phenmetrazine (0.032-0.1 mg/kg/h). Subsequently, the FR response requirement for cocaine or food was varied (food, FR 100; cocaine, FR 1-100; cocaine, FR 10; food, FR 10-300), and effects of phenmetrazine on cocaine vs food choice were redetermined. Decreases in the cocaine FR or increases in the food FR resulted in leftward shifts in the cocaine choice dose-effect curve, whereas increases in the cocaine FR or decreases in the food FR resulted in rightward shifts in the cocaine choice dose-effect curve. The efficacy of phenmetrazine to decrease cocaine choice varied systematically as a function of the prevailing response requirements, such that phenmetrazine efficacy was greatest when cocaine choice was maintained by relatively low unit cocaine doses. These results suggest that efficacy of pharmacotherapies to modulate cocaine use can be influenced by behavioral contingencies of cocaine availability. Agonist medications may be most effective under contingencies that engender choice of relatively low cocaine doses.

33 CFR 117.881 - John Day River.

Code of Federal Regulations, 2010 CFR

2010-07-01

... below Bonneville Dam. [CGD 82-025, 49 FR 17452, Apr. 24, 1984, as amended by CGD13 91-07, 56 FR 67528, Dec. 31, 1991; USCG-2000-7223, 65 FR 40056, June 29, 2000; USCG-2001-10881, 71 FR 70312, Dec. 4, 2006] ...

33 CFR 117.881 - John Day River.

Code of Federal Regulations, 2011 CFR

2011-07-01

... below Bonneville Dam. [CGD 82-025, 49 FR 17452, Apr. 24, 1984, as amended by CGD13 91-07, 56 FR 67528, Dec. 31, 1991; USCG-2000-7223, 65 FR 40056, June 29, 2000; USCG-2001-10881, 71 FR 70312, Dec. 4, 2006] ...

77 FR 71192 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-29

..., Report of Changes in Organizational Structure, and FR Y-6, Annual Report of Holding Companies (OMB No... the FR Y-10 and FR Y-6 is not appropriately tailored for DFMUs, and structure data with respect to...

49 CFR 385.17 - Change to safety rating based upon corrective actions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... in CMVs or placardable quantities of hazardous materials. (2) Within 45 days for all other motor.... [65 FR 50935, Aug. 22, 2000, as amended at 72 FR 36788, July 5, 2007; 75 FR 17241, Apr. 5, 2010; 77 FR...

49 CFR 385.17 - Change to safety rating based upon corrective actions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... in CMVs or placardable quantities of hazardous materials. (2) Within 45 days for all other motor.... [65 FR 50935, Aug. 22, 2000, as amended at 72 FR 36788, July 5, 2007; 75 FR 17241, Apr. 5, 2010; 77 FR...

Morphology, Spatial Distribution, and Concentration of Flame Retardants in Consumer Products and Environmental Dusts using Scanning Electron Microscopy and Raman Micro-spectroscopy

PubMed Central

WAGNER, JEFF; GHOSAL, SUTAPA; WHITEHEAD, TODD; METAYER, CATHERINE

2013-01-01

We characterized flame retardant (FR) morphologies and spatial distributions in 7 consumer products and 7 environmental dusts to determine their implications for transfer mechanisms, human exposure, and the reproducibility of gas chromatography-mass spectrometry (GC-MS) dust measurements. We characterized individual particles using scanning electron microscopy / energy dispersive x-ray spectroscopy (SEM/EDS) and Raman micro-spectroscopy (RMS). Samples were screened for the presence of 3 FR constituents (bromine, phosphorous, non-salt chlorine) and 2 metal synergists (antimony and bismuth). Subsequent analyses of select samples by RMS enabled molecular identification of the FR compounds and matrix materials. The consumer products and dust samples possessed FR elemental weight percents of up to 36% and 31%, respectively. We identified 24 FR-containing particles in the dust samples and classified them into 9 types based on morphology and composition. We observed a broad range of morphologies for these FR-containing particles, suggesting FR transfer to dust via multiple mechanisms. We developed an equation to describe the heterogeneity of FR-containing particles in environmental dust samples. The number of individual FR-containing particles expected in a 1-mg dust sample with a FR concentration of 100 ppm ranged from <1 to >1000 particles. The presence of rare, high-concentration bromine particles was correlated with decabromodiphenyl ether concentrations obtained via GC-MS. When FRs are distributed heterogeneously in highly concentrated dust particles, human exposure to FRs may be characterized by high transient exposures interspersed by periods of low exposure, and GC-MS FR concentrations may exhibit large variability in replicate subsamples. Current limitations of this SEM/EDS technique include potential false negatives for volatile and chlorinated FRs and greater quantitation uncertainty for brominated FR in aluminum-rich matrices. PMID:23739093

Simple and easy assessment of falling risk in the elderly by functional reach test using elastic stick.

PubMed

Demura, Shin-Ichi; Yamada, Takayoshi

2007-10-01

Dynamic balance ability related to maintaining postural stability during movement is closely tied to fall risk in the elderly. The functional reach (FR) test has been developed to evaluate their dynamic balance. Although a simple and new FR test using an elastic stick has been proposed by modifying the above original FR test, the abilities related to both FR tests are judged to differ because of the large difference in the testing method. This study aimed to compare center of gravity fluctuation, muscle activity and functional reach distance as measured by the original FR test and the elastic stick FR test. First, reach distance, back/forth and right/left moving distance of the center of gravity, and activity of the lower leg muscles (soleus and tibialis anterior) were compared between both tests based on data obtained from 30 young male adults. All parameters except for the right/left moving distance were significantly larger in the elastic stick FR test. Next, the reach distance was examined in both FR tests using 53 elderly subjects; it was significantly longer in the elastic stick FR test, but showed no significant sex difference. The reach distance in both tests was significantly shorter (about 7 cm) in the elderly than in young adults. In conclusion, the elastic stick FR test involves greater leg muscle strength exertion and forward transferring of the center of gravity as compared with the original FR test. Because the elastic stick FR test relates largely to leg muscle function and equilibrium function, it may be more useful for evaluating the dynamic balance ability of the elderly.

Gridded precipitation fields at high temporal and spatial resolution for operational flood forecasting in the Rhine basin

NASA Astrophysics Data System (ADS)

van Osnabrugge, Bart; Weerts, Albrecht; Uijlenhoet, Remko

2017-04-01

Gridded areal precipitation, as one of the most important hydrometeorological input variables for initial state estimation in operational hydrological forecasting, is available in the form of raster data sets (e.g. HYRAS and EOBS) for the River Rhine basin. These datasets are compiled off-line on a daily time step using station data with the highest possible spatial density. However, such a product is not available operationally and at an hourly discretisation. Therefore, we constructed an hourly gridded precipitation dataset at 1.44 km2 resolution for the Rhine basin for the period from 1998 to present using a REGNIE-like interpolation procedure (Weerts et al., 2008) using a low and a high density rain gauge network. The datasets were validated against daily HYRAS (Rauthe, 2013) and EOBS (Haylock, 2008) data. The main goal of the operational procedure is to emulate the HYRAS dataset as good as possible, as the daily HYRAS dataset is used in the off-line calibration of the hydrological model. Our main findings are that even with low station density, the spatial patterns found in the HYRAS data set are well reproduced. With low station density (years 1999-2006) our dataset underestimates precipitation compared to HYRAS and EOBS, notably during the winter. However, interpolation based on the same set of stations overestimates precipitation compared to EOBS for the years 2006-2014. This discrepancy disappears when switching to the high station density. We also analyze the robustness of the hourly precipitation fields by comparing with stations not used during interpolation. Specific issues regarding the data when creating the gridded precipitation fields will be highlighted. Finally, the datasets are used to drive an hourly and daily gridded WFLOW_HBV model of the Rhine at the same spatial resolution. Haylock, M.R., N. Hofstra, A.M.G. Klein Tank, E.J. Klok, P.D. Jones and M. New. 2008: A European daily high-resolution gridded dataset of surface temperature and precipitation. J. Geophys. Res (Atmospheres), 113, D20119, doi:10.1029/2008JD10201 Rauthe, M., Steiner, H., Riediger, U., Mazurkiewicz, A., Gratzki, A. 2013: A Central European precipitation climatology - Part 1: Generation and validation of a high-resolution gridded daily data set (HYRAS). Meteorologische Zeitschrift, 22(3), 235 256 Weerts, A.H., D. Meißner, and S. Rademacher, 2008. Input data rainfall-runoff model operational system FEWS-NL & FEWS-DE. Technical report, Deltares.

Deglaciation and post-glacial environmental evolution in the Western Massif of Picos de Europa

NASA Astrophysics Data System (ADS)

Ruiz-Fernández, Jesús; Oliva, Marc; García, Cristina; López-Sáez, José Antonio; Gallinar, David; Geraldes, Miguel

2014-05-01

This study examines the process of deglaciation of the Western Massif of Picos de Europa through field work, geomorphological mapping, sedimentary records and absolute datings of 14C. This massif has several peaks over 2,400 m a.s.l. (Peña Santa de Castilla, 2,596 m; Torre Santa María, 2,486 m; Torre del Mediu, 2,467 m). It is composed mainly by Carboniferous limestones. This area has been intensively affected by karstic dissolution, Quaternary glaciers and fluvio-torrential processes (Miotke, 1968; Moreno et al, 2010; Ruiz-Fernández et al, 2009; Ruiz-Fernández, 2013). At present day, periglacial processes are active at the highest elevations (Ruiz-Fernández, 2013). We have identified four main glacial stages regarding the deglaciation of the massif: (i) maximum advance corresponding to the Last Glaciation, (ii) retreat and stabilization after the maximum advance, (iii) Late Glacial, and (iv) Little Ice Age. Sedimentological studies also contribute data to the understanding of the chronological framework of these environmental changes. The datings of the bottom sediments in two long sequences (8 and 5.4 m) provided a minimum age of 18,075 ± 425 cal BP for the maximum advance stage and 11,150 ± 900 cal BP for retreat and stabilization in the phase following the maximum advance. The ongoing analyses of these sequences at very high resolution will provide new knowledge about the environmental conditions prevailing since the deglaciation of the massif. References Miotke, F.D. (1968). Karstmorphologische studien in der glazial-überformten Höhenstufe der Picos de Europa, Nordspanien. Hannover, Selbtverlag der Geografischen Gessellschaft, 161 pp. Moreno, A., Valero, B.L., Jiménez, M., Domínguez, M.J., Mata, M.P., Navas, A., González, P., Stoll, H., Farias, P., Morellón, M., Corella, J.P. & Rico, M. (2010). The last deglaciation in the Picos de Europa National Park (Cantabrian Mountains, Northern Spain). Journal of Quaternary Science, 25 (7), 1076-1091. Ruiz-Fernández, J. (2013). Las formas de modelado glaciar, periglaciar y fluviotorrencial del Macizo Occidental de los Picos de Europa (Cordillera Cantábrica). Unpublished PhD Thesis, University of Oviedo, 314 pp. Ruiz-Fernández, J., Poblete. M.A., Serrano, P., Martí, C. & García-Ruiz, J.M. (2009). Morphometry of glacial cirques in the Cantabrian Range (Northwest Spain). Zeitschrift für Geomorphologie N. F., 53, 47-68.

Modeling the weather impact on aviation in a global air traffic model

NASA Astrophysics Data System (ADS)

Himmelsbach, S.; Hauf, T.; Rokitansky, C. H.

2009-09-01

Weather has a strong impact on aviation safety and efficiency. For a better understanding of that impact, especially of thunderstorms and similar other severe hazards, we pursued a modeling approach. We used the detailed simulation software (NAVSIM) of worldwide air traffic, developed by Rokitansky [Eurocontrol, 2005] and implemented a specific weather module. NAVSIM models each aircraft with its specific performance characteristics separately along preplanned and prescribed routes. The specific weather module in its current version simulates a thunderstorm as an impenetrable 3D object, which forces an aircraft to circumvent the latter. We refer to that object in general terms as a weather object. The Cb-weather object, as a specific weather object, is a heuristic model of a real thunderstorm, with its characteristics based on actually observed satellite and precipitation radar data. It is comprised of an upper volume, mostly the anvil, and a bottom volume, the up- and downdrafts and the lower outflow area [Tafferner and Forster, 2009; Kober and Tafferner 2009; Zinner et al, 2008]. The Cb-weather object is already implemented in NAVSIM, other weather objects like icing and turbulence will follow. This combination of NAVSIM with a weather object allows a detailed investigation of situations where conflicts exist between planned flight routes and adverse weather. The first objective is to simulate the observed circum-navigation in NAVSIM. Real occurring routes will be compared with simulated ones. Once this has successfully completed, NAVSIM offers a platform to assess existing rules and develop more efficient strategies to cope with adverse weather. An overview will be given over the implementation status of weather objects within NAVSIM and first results will be presented. Cb-object data provision by A. Tafferner, C. Forster, T. Zinner, K. Kober, M. Hagen (DLR Oberpfaffenhofen) is greatly acknowledged. References: Eurocontrol, VDL Mode 2 Capacity Analysis through Simulations: WP3.B - NAVSIM Overview and Validation Results, Edition 1.2, 2005 Kober K. and A. Tafferner. Tracking and nowcasting of convective cells using remote sensing data from radar and satellite, Meteorologische Zeitschrift, 1 (No. 18), 75-84, 2009 Tafferner A. and C. Forster, Improvement of thunderstorm hazard information for pilots through a ground based weather information and management system, Eighth USA/Europe Air Traffic Management Research and Development Seminar (submitted), 2009 Zinner, T., H. Mannstein, A. Tafferner. Cb-TRAM: Tracking and monitoring severe convection from onset over rapid development to mature phase using multi-channel Meteosat-8 SEVIRI data, Meteorol. Atmos. Phys., 101, 191-210, 2008

40 CFR 52.50 - Identification of plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Coating 10/15/96 6/6/97; 62 FR 30991 Section 335-3-6-.12 Solvent Metal Cleaning 10/15/96 06/6/97; 62 FR... Synthesized Pharmaceutical Products 10/15/96 6/6/97; 62 FR 30991 Section 335-3-6-.19 Reserved Section 335-3-6... Sources 6/22/89 3/19/90; 55 FR 10062 Section 335-3-6-.32 Surface Coating 10/15/96 6/6/97; 62 FR 30991...

Initial experience with the 3.3 Fr Mongoose® pigtail catheter for aortic angiography during patent ductus arteriosus closure in small patients.

PubMed

Hena, Zachary; Sutton, Nicole J; Gates, Gregory J; Taragin, Benjamin H; Pass, Robert H

2017-01-01

Smaller femoral arterial sheaths may be associated with fewer vascular complications. The 3.3 Fr Mongoose ® Pediavascular pigtail catheter is a catheter that allows higher flow rates, potentially resulting in improved angiographic quality. We reviewed our experience with this small catheter during patent ductus arteriosus (PDA) closure. Review of patients ≤20 kg in whom the Mongoose ® catheter was used during PDA closure from 12/13 to 4/15. Angiographic efficacy and procedural details were compared to ten 4 Fr catheter cases. Comparisons were performed using Mann-Whitney U-test; P < 0.05 was statistically significant. Twelve (9 female) patients were catheterized with a 3.3 Fr Mongoose ® . Median weight 10.5 kg (range 6.4-18.2), height 81 cm (range 37-111), and body surface area (BSA) 0.47 m 2 (range 0.33-0.75) were similar to ten patients (3 females) in the 4 Fr control group ( P = NS); median weight 9.9 kg (range 6-16.8), height 80 cm (range 64-102), and BSA 0.46 m2 (range 0.31-0.74). Angiographic quality was subjectively adequate with both with no difference in the median pixel density between the two techniques (3.3 Fr: 76.7 [range 33.5-90] and 4 Fr: [70; 38-102]; P = NS). Contrast used was similar between the groups (3.3 Fr: median 4.2 ml/kg and 4 Fr: 4.9 ml/kg; P = NS). Median radiation dose was similar in the two groups (3.3 Fr: 28.1 mGy [range 17.2-38] and 4 Fr: 38 mGy [range 20.4-58.5]; P = NS). All ducts were closed at latest follow-up ( P = NS). No complications were encountered. The 3.3 Fr Mongoose ® allowed similar angiography to the 4 Fr pigtail catheter, allowing safe and effective transcatheter PDA closure in small children.

78 FR 30327 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-22

.... 15387A Wild Acres Ranch....... 77 FR 26779; May 7, June 20, 2012. 2012. 72654A William Bean 77 FR 26779..., 2012. 2012. 72653A William Bean 77 FR 26779; May 7, June 21, 2012. 2012. 71823A Blex Exchange III, L.P...

"Work ethic" in pigeons: reward value is directly related to the effort or time required to obtain the reward.

PubMed

Clement, T S; Feltus, J R; Kaiser, D H; Zentall, T R

2000-03-01

Stimuli associated with less effort or with shorter delays to reinforcement are generally preferred over those associated with greater effort or longer delays to reinforcement. However, the opposite appears to be true of stimuli that follow greater effort or longer delays. In training, a simple simultaneous discrimination followed a single peck to an initial stimulus (S+FR1 S-FR1) and a different simple simultaneous discrimination followed 20 pecks to the initial stimulus (S+FR20 S-FR20). On test trials, pigeons preferred S+FR20 over S+FR1 and S-FR20 over S-FR1. These data support the view that the state of the animal immediately prior to presentation of the discrimination affects the value of the reinforcement that follows it. This contrast effect is analogous to effects that when they occur in humans have been attributed to more complex cognitive and social factors.

Reconstructing f(R) gravity from a Chaplygin scalar field in de Sitter spacetimes

NASA Astrophysics Data System (ADS)

Sami, Heba; Namane, Neo; Ntahompagaze, Joseph; Elmardi, Maye; Abebe, Amare

We present a reconstruction technique for models of f(R) gravity from the Chaplygin scalar field in flat de Sitter spacetimes. Exploiting the equivalence between f(R) gravity and scalar-tensor (ST) theories, and treating the Chaplygin gas (CG) as a scalar field model in a universe without conventional matter forms, the Lagrangian densities for the f(R) action are derived. Exact f(R) models and corresponding scalar field potentials are obtained for asymptotically de Sitter spacetimes in early and late cosmological expansion histories. It is shown that the reconstructed f(R) models all have General Relativity (GR) as a limiting solution.

76 FR 2721 - Affirmative Decisions on Petitions for Modification Granted in Whole or in Part

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-14

...-2010-004-C FR Notice: 75 FR 12796 March 17, 2010). Petitioner: Jim Walter Resources, Inc., P.O. Box 133... W. Silvey, Certifying Officer. [FR Doc. 2011-686 Filed 1-13-11; 8:45 am] BILLING CODE 4510-43-P ...

76 FR 54717 - Supervised Securities Holding Companies Registration

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2011-09-02

... other financial statements submitted to the securities holding company's current consolidated supervisor... Y-9ES), The Supplement to the Consolidated Financial Statements for Bank Holding Companies (FR Y-9CS... Companies (FR Y-6), The Report of Foreign Banking Organizations (FR Y-7), The Consolidated Financial...

78 FR 76738 - Updated Statements of Legal Authority for the Export Administration Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-19

... 13637 of March 8, 2013, 78 FR 16129 (March 13, 2013), and as extended by the Notice of August 8, 2013.... 5; 22 U.S.C. 7201 et seq.; 22 U.S.C. 7210; E.O. 11912, 41 FR 15825, 3 CFR, 1976 Comp., p. 114; E.O.... 13338, 69 FR 26751, 3 CFR, 2004 Comp., p 168; E.O. 13637 of March 8, 2013, 78 FR 16129 (March 13, 2013...

Deep vein thrombosis using noncontrast-enhanced MR venography with electrocardiographically gated three-dimensional half-Fourier FSE: preliminary experience.

PubMed

Ono, Atsushi; Murase, Kenya; Taniguchi, Toshitaka; Shibutani, Osamu; Takata, Satoru; Kobashi, Yasuyuki; Miyazaki, Mitsue

2009-04-01

Three noncontrast-enhanced MR venography techniques are presented for assessing deep vein thrombosis (DVT) at 0.5 T in patients with metallic implants. Two cardiac-gated 3D half-Fourier FSE fresh blood imaging sequences with flow-refocusing pulses (FR-FBI) in the read-out (RO) direction and without FR pulses (non-FR-FBI) were developed for slower-flowing blood. For faster flowing blood, a swap phase-encode arterial double-subtraction elimination (SPADE) technique was developed. The three techniques were assessed both quantitatively using signal-to-noise (SNR) and contrast-noise-ratio (CNR) measurements and qualitatively by subjective image analysis in 15 volunteers. SPADE was compared to FR-FBI in the pelvic veins and FR-FBI was compared to non-FR-FBI in the thigh and calf veins. Both SPADE and FR-FBI techniques produced significantly higher SNRs, CNRs, and image quality in each comparative study (P<0.001). Five patients with metallic implants and confirmed DVT underwent SPADE (pelvic veins) and FR-FBI (thigh and calf veins) examinations and the results were compared to conventional venography. The SPADE and FR-FBI images showed all DVTs from all five patients without interference from implant susceptibility artifacts. The excellent image quality produced by both SPADE and FR-FBI throughout peripheral vasculature demonstrates their promise for detecting DVT in postsurgery patients.

Relationship between instantaneous wave-free ratio and fractional flow reserve in patients receiving hemodialysis.

PubMed

Morioka, Yuta; Arashi, Hiroyuki; Otsuki, Hisao; Yamaguchi, Junichi; Hagiwara, Nobuhisa

2017-06-22

Instantaneous wave-free ratio (iFR) is a vasodilator-free index and is reported to have a good correlation with fractional flow reserve (FFR). Hemodialysis patients exhibit left ventricular hypertrophy, reduced arterial compliance, and impaired microcirculation. Such a coronary flow condition in these patients may influence the relationship between iFR and FFR. This study assessed the impact of hemodialysis on the relationship between iFR and FFR. The study enrolled 196 patients with 265 stenoses who underwent assessment via iFR, FFR assessment, and right heart catheterization. A good correlation between iFR and FFR was observed in hemodialysis patients. iFR in the hemodialysis group was significantly lower than in the non-hemodialysis group (0.81 ± 0.13 vs. 0.86 ± 0.13, p = 0.005), although no significant difference was found in FFR and percentage diameter stenosis. An iFR value of 0.84 was found to be equivalent to an FFR value of 0.8 in hemodialysis patients, which was lower than the standard predictive iFR range for ischemia. Vasodilator-free assessment by iFR could be beneficial in evaluating intermediate coronary stenosis in patients receiving hemodialysis. However, the threshold for iFR abnormality needs adjustment in hemodialysis patients, and larger clinical trials are required to confirm the results in this specific subset.

Radial force distribution changes associated with tangential force production in cylindrical grasping, and the importance of anatomical registration.

PubMed

Pataky, Todd C; Slota, Gregory P; Latash, Mark L; Zatsiorsky, Vladimir M

2012-01-10

Radial force (F(r)) distributions describe grip force coordination about a cylindrical object. Recent studies have employed only explicit F(r) tasks, and have not normalized for anatomical variance when considering F(r) distributions. The goals of the present study were (i) to explore F(r) during tangential force production tasks, and (ii) to examine the extent to which anatomical registration (i.e. spatial normalization of anatomically analogous structures) could improve signal detectability in F(r) data. Twelve subjects grasped a vertically oriented cylindrical handle (diameter=6 cm) and matched target upward tangential forces of 10, 20, and 30 N. F(r) data were measured using a flexible pressure mat with an angular resolution of 4.8°, and were registered using piecewise-linear interpolation between five manually identified points-of-interest. Results indicate that F(r) was primarily limited to three contact regions: the distal thumb, the distal fingers, and the fingers' metatacarpal heads, and that, while increases in tangential force caused significant increases in F(r) for these regions, they did not significantly affect the F(r) distribution across the hand. Registration was found to substantially reduce between-subject variability, as indicated by both accentuated F(r) trends, and amplification of the test statistic. These results imply that, while subjects focus F(r) primarily on three anatomical regions during cylindrical grasp, inter-subject anatomical differences introduce a variability that, if not corrected for via registration, may compromise one's ability to draw anatomically relevant conclusions from grasping force data. Copyright © 2011 Elsevier Ltd. All rights reserved.

29 CFR 1952.367 - Changes to approved plans.

Code of Federal Regulations, 2010 CFR

2010-07-01

... plans. (a) Legislation. (1) On March 29, 1994, the Assistant Secretary approved New Mexico's revised... Secretary on September 24, 1997. [59 FR 14556, Mar. 29, 1994. Redesignated at 59 FR 42496, Aug. 18, 1994, as amended at 62 FR 49911, Sept. 24, 1997; 67 FR 60129, Sept. 25, 2002] ...

7 CFR 29.3068 - Tannish-red color (FR).

Code of Federal Regulations, 2012 CFR

2012-01-01

... Type 93) § 29.3068 Tannish-red color (FR). A light red shaded toward tan. [24 FR 8771, Oct. 29, 1959... 7 Agriculture 2 2012-01-01 2012-01-01 false Tannish-red color (FR). 29.3068 Section 29.3068 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards...

7 CFR 29.3068 - Tannish-red color (FR).

Code of Federal Regulations, 2011 CFR

2011-01-01

... Type 93) § 29.3068 Tannish-red color (FR). A light red shaded toward tan. [24 FR 8771, Oct. 29, 1959... 7 Agriculture 2 2011-01-01 2011-01-01 false Tannish-red color (FR). 29.3068 Section 29.3068 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards...

7 CFR 29.3068 - Tannish-red color (FR).

Code of Federal Regulations, 2014 CFR

2014-01-01

... Type 93) § 29.3068 Tannish-red color (FR). A light red shaded toward tan. [24 FR 8771, Oct. 29, 1959... 7 Agriculture 2 2014-01-01 2014-01-01 false Tannish-red color (FR). 29.3068 Section 29.3068 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards...

7 CFR 29.3068 - Tannish-red color (FR).

Code of Federal Regulations, 2013 CFR

2013-01-01

... Type 93) § 29.3068 Tannish-red color (FR). A light red shaded toward tan. [24 FR 8771, Oct. 29, 1959... 7 Agriculture 2 2013-01-01 2013-01-01 false Tannish-red color (FR). 29.3068 Section 29.3068 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards...

48 CFR 13.501 - Special documentation requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Special documentation... and complete to the best of the contracting officer's knowledge and belief will serve as approval...; 69 FR 76352, Dec. 20, 2004; 70 FR 57457, Sept. 30, 2005; 71 FR 57360, 57366, Sept. 28, 2006; 75 FR...

48 CFR 13.501 - Special documentation requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Special documentation... and complete to the best of the contracting officer's knowledge and belief will serve as approval...; 69 FR 76352, Dec. 20, 2004; 70 FR 57457, Sept. 30, 2005; 71 FR 57360, 57366, Sept. 28, 2006; 75 FR...

78 FR 76154 - Allocations, Waivers, and Alternative Requirements for Grantees Receiving Community Development...

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76 FR 79063 - Appliance Labeling Rule

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-21

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10 CFR 51.45 - Environmental report.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Environmental report. 51.45 Section 51.45 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED... amended at 61 FR 28486, June 5, 1996; 61 FR 66542, Dec. 18, 1996; 68 FR 58810, Oct. 10, 2003; 72 FR 49511...

7 CFR 29.3068 - Tannish-red color (FR).

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Tannish-red color (FR). 29.3068 Section 29.3068 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... Type 93) § 29.3068 Tannish-red color (FR). A light red shaded toward tan. [24 FR 8771, Oct. 29, 1959...

40 CFR 78.4 - Filings.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 17 2014-07-01 2014-07-01 false Filings. 78.4 Section 78.4 Protection... be made on personal knowledge and belief, set forth only those facts that are admissible into..., Dec. 18, 1997; 69 FR 21645, Apr. 21, 2004; 70 FR 25339, May 12, 2005; 75 FR 75078, Dec. 1, 2010; 76 FR...

40 CFR 78.4 - Filings.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Filings. 78.4 Section 78.4 Protection... be made on personal knowledge and belief, set forth only those facts that are admissible into..., Dec. 18, 1997; 69 FR 21645, Apr. 21, 2004; 70 FR 25339, May 12, 2005; 75 FR 75078, Dec. 1, 2010; 76 FR...

22 CFR 127.12 - Voluntary disclosures.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Voluntary disclosures. 127.12 Section 127.12... the voluntary disclosure are true and correct to the best of that person's knowledge and belief... amended at 70 FR 34655, June 15, 2005; 71 FR 20550, Apr. 21, 2006; 72 FR 70778, Dec. 13, 2007; 77 FR 16642...

22 CFR 127.12 - Voluntary disclosures.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Voluntary disclosures. 127.12 Section 127.12... the voluntary disclosure are true and correct to the best of that person's knowledge and belief... amended at 70 FR 34655, June 15, 2005; 71 FR 20550, Apr. 21, 2006; 72 FR 70778, Dec. 13, 2007; 77 FR 16642...

40 CFR 78.4 - Filings.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 17 2012-07-01 2012-07-01 false Filings. 78.4 Section 78.4 Protection... be made on personal knowledge and belief, set forth only those facts that are admissible into..., Dec. 18, 1997; 69 FR 21645, Apr. 21, 2004; 70 FR 25339, May 12, 2005; 75 FR 75078, Dec. 1, 2010; 76 FR...

5 CFR 2634.905 - Use of alternative procedures.

Code of Federal Regulations, 2010 CFR

2010-01-01

... available source, such as the Office of Government Ethics' Web site on the Internet or agency-approved... examination prior to completing an OGE Optional Form 450-A. [57 FR 11826, Apr. 7, 1992; 57 FR 21855, May 22, 1992, as amended at 62 FR 33976, June 24, 1997; 71 FR 28235, May 16, 2006] ...

40 CFR 52.2436 - Rules and regulations.

Code of Federal Regulations, 2013 CFR

2013-07-01

.... [38 FR 33725, Dec. 6, 1973, as amended at 45 FR 55197, Aug. 19, 1980; 51 FR 40677, Nov. 7, 1986; 61 FR... 40 Protection of Environment 5 2013-07-01 2013-07-01 false Rules and regulations. 52.2436 Section...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Virginia § 52.2436 Rules and regulations. (a...

40 CFR 52.2436 - Rules and regulations.

Code of Federal Regulations, 2012 CFR

2012-07-01

.... [38 FR 33725, Dec. 6, 1973, as amended at 45 FR 55197, Aug. 19, 1980; 51 FR 40677, Nov. 7, 1986; 61 FR... 40 Protection of Environment 5 2012-07-01 2012-07-01 false Rules and regulations. 52.2436 Section...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Virginia § 52.2436 Rules and regulations. (a...

40 CFR 52.2436 - Rules and regulations.

Code of Federal Regulations, 2011 CFR

2011-07-01

.... [38 FR 33725, Dec. 6, 1973, as amended at 45 FR 55197, Aug. 19, 1980; 51 FR 40677, Nov. 7, 1986; 61 FR... 40 Protection of Environment 4 2011-07-01 2011-07-01 false Rules and regulations. 52.2436 Section...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Virginia § 52.2436 Rules and regulations. (a...

40 CFR 52.2436 - Rules and regulations.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... [38 FR 33725, Dec. 6, 1973, as amended at 45 FR 55197, Aug. 19, 1980; 51 FR 40677, Nov. 7, 1986; 61 FR... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Rules and regulations. 52.2436 Section...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Virginia § 52.2436 Rules and regulations. (a...

29 CFR 1952.174 - Completion of developmental steps and certification.

Code of Federal Regulations, 2010 CFR

2010-07-01

... April 24, 1973, on or before June 1, 1976, with the exception that temporary labor camp standards... at 40 FR 40156, Sept. 2, 1975; 40 FR 54426, Nov. 24, 1975; 41 FR 43405, Oct. 1, 1976; 41 FR 51013..., 1976. (k) Recordkeeping and reporting requirements for private employers were promulgated by November...

31 CFR 357.26 - Direct Deposit.

Code of Federal Regulations, 2011 CFR

2011-07-01

... AND BILLS HELD IN TREASURY/RESERVE AUTOMATED DEBT ENTRY SYSTEM (TRADES) AND LEGACY TREASURY DIRECT... least one name that is common to both. (c) Inquiry to financial institution. Where the deposit account...) [51 FR 18265, May 16, 1986, as amended at 57 FR 38774, Aug. 27, 1992; 61 FR 6113, Feb. 16, 1996; 64 FR...

31 CFR 357.26 - Direct Deposit.

Code of Federal Regulations, 2013 CFR

2013-07-01

... AND BILLS HELD IN TREASURY/RESERVE AUTOMATED DEBT ENTRY SYSTEM (TRADES) AND LEGACY TREASURY DIRECT... least one name that is common to both. (c) Inquiry to financial institution. Where the deposit account...) [51 FR 18265, May 16, 1986, as amended at 57 FR 38774, Aug. 27, 1992; 61 FR 6113, Feb. 16, 1996; 64 FR...

31 CFR 357.26 - Direct Deposit.

Code of Federal Regulations, 2012 CFR

2012-07-01

... AND BILLS HELD IN TREASURY/RESERVE AUTOMATED DEBT ENTRY SYSTEM (TRADES) AND LEGACY TREASURY DIRECT... least one name that is common to both. (c) Inquiry to financial institution. Where the deposit account...) [51 FR 18265, May 16, 1986, as amended at 57 FR 38774, Aug. 27, 1992; 61 FR 6113, Feb. 16, 1996; 64 FR...

31 CFR 357.26 - Direct Deposit.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., NOTES AND BILLS HELD IN TREASURY/RESERVE AUTOMATED DEBT ENTRY SYSTEM (TRADES) AND LEGACY TREASURY DIRECT... least one name that is common to both. (c) Inquiry to financial institution. Where the deposit account...) [51 FR 18265, May 16, 1986, as amended at 57 FR 38774, Aug. 27, 1992; 61 FR 6113, Feb. 16, 1996; 64 FR...

78 FR 6107 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-29

... Derivatives Market Activity (FR 3036; OMB No. 7100-0285). The FR 2436 collects similar data on the outstanding... of Foreign Exchange and Derivative Market Activity. Agency form number: FR 3036. OMB control number... and derivatives market and dealers. Estimated annual reporting hours: Turnover Survey, 2,275 hours...

78 FR 34120 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-06

...; August 27, October 31, 2012. 2012. 704654 Scovill Zoo 77 FR 51819; August 27, October 31, 2012. 2012... Cincinnati Zoo & Botanical 77 FR 61627; October 10, November 16, 2012. Garden. 2012. 679042 Duke Lemur Center... Simon Ranch LLC 77 FR 61627; October 10, November 16, 2012. 2012. 819063 Tautphaus Park Zoo........ 77...

FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p

PubMed Central

Helliwell, Stephen B.; Karkare, Shantanu; Bergdoll, Marc; Rahier, Alain; Leighton-Davis, Juliet R.; Fioretto, Celine; Aust, Thomas; Filipuzzi, Ireos; Frederiksen, Mathias; Gounarides, John; Hoepfner, Dominic; Hofmann, Andreas; Imbert, Pierre-Eloi; Jeker, Rolf; Knochenmuss, Richard; Krastel, Philipp; Margerit, Anais; Memmert, Klaus; Miault, Charlotte V.; Rao Movva, N.; Muller, Alban; Naegeli, Hans-Ulrich; Oberer, Lukas; Prindle, Vivian; Riedl, Ralph; Schuierer, Sven; Sexton, Jessica A.; Tao, Jianshi; Wagner, Trixie; Yin, Hong; Zhang, Juan; Roggo, Silvio; Reinker, Stefan; Parker, Christian N.

2015-01-01

FR171456 is a natural product with cholesterol-lowering properties in animal models, but its molecular target is unknown, which hinders further drug development. Here we show that FR171456 specifically targets the sterol-4-alpha-carboxylate-3-dehydrogenase (Saccharomyces cerevisiae—Erg26p, Homo sapiens—NSDHL (NAD(P) dependent steroid dehydrogenase-like)), an essential enzyme in the ergosterol/cholesterol biosynthesis pathway. FR171456 significantly alters the levels of cholesterol pathway intermediates in human and yeast cells. Genome-wide yeast haploinsufficiency profiling experiments highlight the erg26/ERG26 strain, and multiple mutations in ERG26 confer resistance to FR171456 in growth and enzyme assays. Some of these ERG26 mutations likely alter Erg26 binding to FR171456, based on a model of Erg26. Finally, we show that FR171456 inhibits an artificial Hepatitis C viral replicon, and has broad antifungal activity, suggesting potential additional utility as an anti-infective. The discovery of the target and binding site of FR171456 within the target will aid further development of this compound. PMID:26456460

On the renormalization group perspective of α-attractors

NASA Astrophysics Data System (ADS)

Narain, Gaurav

2017-10-01

In this short paper we outline a recipe for the reconstruction of F(R) gravity starting from single field inflationary potentials in the Einstein frame. For simple potentials one can compute the explicit form of F(R), whilst for more involved examples one gets a parametric form of F(R). The F(R) reconstruction algorithm is used to study various examples: power-law phin, exponential and α-attractors. In each case it is seen that for large R (corresponding to large value of inflaton field), F(R) ~ R2. For the case of α-attractors F(R) ~ R2 for all values of inflaton field (for all values of R) as α → 0. For generic inflaton potential V(phi), it is seen that if V'/V →0 (for some phi) then the corresponding F(R) ~ R2. We then study α-attractors in more detail using non-perturbative renormalisation group methods to analyse the reconstructed F(R). It is seen that α→0 is an ultraviolet stable fixed point of the renormalisation group trajectories.

Feasibility and safety of transfemoral intra-arterial chemotherapy for head and neck cancer using a 3-French catheter system: comparison with a 4-French catheter system.

PubMed

Watanabe, Shigeru; Yamamoto, Akira; Torigoe, Teruyuki; Kanki, Akihiko; Tamada, Tsutomu; Ito, Katsuyoshi

2016-02-01

To assess the technical feasibility of transfemoral intra-arterial chemotherapy for head and neck cancer using a 3-French catheter system (3-Fr). Sixty-two patients with head and neck cancer who underwent transfemoral intra-arterial chemotherapy were included in this study. Thirty-three patients underwent treatment using a 3-Fr (group 3-Fr). Twenty-nine patients underwent treatment using a 4-French catheter system (group 4-Fr). The technical success rate, duration of the procedure with fluoroscopy, and rate of procedure-related complications were compared between group 3-Fr and group 4-Fr. In addition, in group 3-Fr, bleeding at the puncture site after 1.5 h of bed rest was evaluated. The technical success rate was 100% in both groups. The duration of the procedure with fluoroscopy didn't differ between group 3-Fr (mean 28.0 min) and group 4-Fr (mean 30.2 min) (p = 0.524). There was no procedure-related complication in either group. In group 3-Fr, no hemorrhagic complication was observed. A 3-French catheter system can be used to perform transfemoral intra-arterial chemotherapy for head and neck cancer and is technically feasible with approximately the same duration of the procedure with fluoroscopy. Furthermore, this method may shorten the bed rest time without hemorrhagic complication, and may reduce the risk of pulmonary embolism.

Effects of the tripeptide substance P antagonist, FR113680, on airway constriction and airway edema induced by neurokinins in guinea-pigs.

PubMed

Murai, M; Morimoto, H; Maeda, Y; Fujii, T

1992-06-24

FR113680 is a newly developed tripeptide substance P (SP) receptor antagonist. The effects of FR113680 on airway constriction and airway edema induced by neurokinins were investigated in guinea-pigs. In in vitro experiments, FR113680 inhibited the contraction of isolated guinea-pig trachea induced by SP and neurokinin A (NKA) in a dose-dependent manner with IC50 values of 2.3 x 10(-6) and 1.5 x 10(-5) M, respectively. The tracheal contraction induced by histamine and acetylcholine was not affected by FR113680. FR113680 (5 x 10(-5) M) also significantly inhibited the atropine-resistant contraction of isolated guinea-pig bronchi induced by electrical field stimulation. In in vivo experiments, FR113680 given i.v. inhibited SP-induced airway constriction in guinea-pigs at doses of 1 and 10 mg kg-1. However, FR113680 only inhibited NKA- and capsaicin-induced airway constriction by 40-50% even at a dose of 10 mg kg-1. FR113680 also inhibited SP-induced airway edema in guinea-pigs with the same potency as it inhibited SP-induced airway constriction. Histamine-induced airway constriction and airway edema were not affected at a dose of 10 mg kg-1. These results suggest that FR113680 preferentially inhibits responses induced by NK1 receptor activation (SP-induced airway constriction and airway edema), but is less effective on a NK2 receptor-induced response (airway constriction by NKA and neurogenic stimulation).

Changes in nucleus accumbens and neostriatal c-Fos and DARPP-32 immunoreactivity during different stages of food-reinforced instrumental training.

PubMed

Segovia, Kristen N; Correa, Merce; Lennington, Jessica B; Conover, Joanne C; Salamone, John D

2012-04-01

Nucleus accumbens is involved in several aspects of instrumental behavior, motivation and learning. Recent studies showed that dopamine (DA) release in the accumbens shell was significantly increased on the first day of training on a fixed ratio (FR) 5 schedule (i.e. the transition from FR1 to FR5) compared with those rats that continued FR1 training, even though the rats on their first day of FR5 training received less food reinforcement than rats continuing on the FR1 schedule. Additionally, the second day of FR5 responding was marked by a significant increase in DA release in accumbens core. The present studies employed immunohistochemical methods to characterize the changes in cellular markers of accumbens and neostriatal neural activity that occur during various stages of food-reinforced FR5 training. c-Fos and DARPP-32 immunoreactivity in accumbens shell was significantly increased on the first day of FR5 training, while core c-Fos and DARPP-32 expression showed large increases on the second day of FR5 training. Additional studies showed that c-Fos and DARPP-32 expression in neostriatum increased after more extensive training. Double-labeling studies with immunofluorescence methods indicated that increases in accumbens c-Fos and DARPP-32 expression were primarily seen in substance-P-positive neurons. These increases in accumbens c-Fos and DARPP-32 immunoreactivity seen during the initial phases of FR training may reflect several factors, including novelty, learning, stress or the presentation of a work-related challenge to the organism. Moreover, it appears that the separate subregions of the striatal complex are differentially activated at distinct phases of instrumental training. © 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.

Physiological and Genetic Characterization of End-of-Day Far-Red Light Response in Maize Seedlings1[W][OA

PubMed Central

Dubois, Patrice G.; Olsefski, Gregory T.; Flint-Garcia, Sherry; Setter, Tim L.; Hoekenga, Owen A.; Brutnell, Thomas P.

2010-01-01

Developmental responses associated with end-of-day far-red light (EOD-FR) signaling were investigated in maize (Zea mays subspecies mays) seedlings. A survey of genetically diverse inbreds of temperate and tropical/semitropical origins, together with teosinte (Zea mays subspecies parviglumis) and a modern hybrid, revealed distinct elongation responses. A mesocotyl elongation response to the EOD-FR treatment was largely absent in the tropical/semitropical lines, but both hybrid and temperate inbred responses were of the same magnitude as in teosinte, suggesting that EOD-FR-mediated mesocotyl responses were not lost during the domestication or breeding process. The genetic architecture underlying seedling responses to EOD-FR was investigated using the intermated B73 × Mo17 mapping population. Among the different quantitative trait loci identified, two were consistently detected for elongation and responsiveness under EOD-FR, but none were associated with known light signaling loci. The central role of phytochromes in mediating EOD-FR responses was shown using a phytochromeB1 phytochromeB2 (phyB1 phyB2) mutant series. Unlike the coleoptile and first leaf sheath, EOD-FR-mediated elongation of the mesocotyl appears predominantly controlled by gibberellin. EOD-FR also reduced abscisic acid (ABA) levels in the mesocotyl for both the wild type and phyB1 phyB2 double mutants, suggesting a FR-mediated but PHYB-independent control of ABA accumulation. EOD-FR elongation responses were attenuated in both the wild type and phyB1 phyB2 double mutants when a chilling stress was applied during the dark period, concomitant with an increase in ABA levels. We present a model for the EOD-FR response that integrates light and hormonal control of seedling elongation. PMID:20668057

Externalizing behaviors in preadolescents: familial risk to externalizing behaviors and perceived parenting styles.

PubMed

Buschgens, Cathelijne J M; van Aken, Marcel A G; Swinkels, Sophie H N; Ormel, Johan; Verhulst, Frank C; Buitelaar, Jan K

2010-07-01

The aim was to investigate the contribution of familial risk to externalizing behaviors (FR-EXT), perceived parenting styles, and their interactions to the prediction of externalizing behaviors in preadolescents. Participants were preadolescents aged 10-12 years who participated in TRAILS, a large prospective population-based cohort study in the Netherlands (N = 2,230). Regression analyses were used to determine the relative contribution of FR-EXT and perceived parenting styles to parent and teacher ratings of externalizing behaviors. FR-EXT was based on lifetime parental externalizing psychopathology and the different parenting styles (emotional warmth, rejection, and overprotection) were based on the child's perspective. We also investigated whether different dimensions of perceived parenting styles had different effects on subdomains of externalizing behavior. We found main effects for FR-EXT (vs. no FR-EXT), emotional warmth, rejection, and overprotection that were fairly consistent across rater and outcome measures. More specific, emotional warmth was the most consistent predictor of all outcome measures, and rejection was a stronger predictor of aggression and delinquency than of inattention. Interaction effects were found for FR-EXT and perceived parental rejection and overprotection; other interactions between FR-EXT and parenting styles were not significant. Correlations between FR-EXT and perceived parenting styles were absent or very low and were without clinical significance. Predominantly main effects of FR-EXT and perceived parenting styles independently contribute to externalizing behaviors in preadolescents, suggesting FR-EXT and parenting styles to be two separate areas of causality. The relative lack of gene-environment interactions may be due to the epidemiological nature of the study, the preadolescent age of the subjects, the measurement level of parenting and the measurement level of FR-EXT, which might be a consequence of both genetic and environmental factors.

Mitigation of Faraday rotation in ALOS-2/PALSAR-2 full polarimetric SAR imageries

NASA Astrophysics Data System (ADS)

Mohanty, Shradha; Singh, Gulab

2016-05-01

The ionosphere, which extends from 50-450 kms in earth's atmosphere, is a particularly important region with regards electromagnetic wave propagation and radio communications in the L-band and lower frequencies. These ions interact with the traversing electromagnetic wave and cause rotation of polarization of the radar signal. In this paper, a potentially computable method for quantifying Faraday rotation (FR), is discussed with the knowledge of full polarimetric ALOS/PALSAR data and ALOS-2/PALSAR-2 data. For a well calibrated monostatic, full-pol ALOS-2/PALSAR-2 data, the reciprocal symmetry of the received scattering matrix is violated due to FR. Apart from FR, other system parameters like residual system noise, channel amplitude, phase imbalance and cross-talk, also account for the non-symmetry. To correct for the FR effect, firstly the noise correction was performed. PALSAR/PALSAR-2 data was converted into 4×4 covariance matrix to calculate the coherence between cross-polarized elements. Covariance matrix was modified by the coherence factor. For FR corrections, the covariance matrix was converted into 4×4 coherency matrix. The elements of coherency matrix were used to estimate FR angle and correct for FR. Higher mean FR values during ALOS-PALSAR measurements can be seen in regions nearer to the equator and the values gradually decrease with increase in latitude. Moreover, temporal variations in FR can also be noticed over different years (2006-2010), with varying sunspot activities for the Niigata, Japan test site. With increasing sunspot activities expected during ALOS-2/PALSAR-2 observations, more striping effects were observed over Mumbai, India. This data has also been FR corrected, with mean FR values of about 8°, using the above mentioned technique.

Morphology, spatial distribution, and concentration of flame retardants in consumer products and environmental dusts using scanning electron microscopy and Raman micro-spectroscopy.

PubMed

Wagner, Jeff; Ghosal, Sutapa; Whitehead, Todd; Metayer, Catherine

2013-09-01

We characterized flame retardant (FR) morphologies and spatial distributions in 7 consumer products and 7 environmental dusts to determine their implications for transfer mechanisms, human exposure, and the reproducibility of gas chromatography-mass spectrometry (GC-MS) dust measurements. We characterized individual particles using scanning electron microscopy/energy dispersive x-ray spectroscopy (SEM/EDS) and Raman micro-spectroscopy (RMS). Samples were screened for the presence of 3 FR constituents (bromine, phosphorous, non-salt chlorine) and 2 metal synergists (antimony and bismuth). Subsequent analyses of select samples by RMS enabled molecular identification of the FR compounds and matrix materials. The consumer products and dust samples possessed FR elemental weight percents of up to 36% and 31%, respectively. We identified 24 FR-containing particles in the dust samples and classified them into 9 types based on morphology and composition. We observed a broad range of morphologies for these FR-containing particles, suggesting FR transfer to dust via multiple mechanisms. We developed an equation to describe the heterogeneity of FR-containing particles in environmental dust samples. The number of individual FR-containing particles expected in a 1-mg dust sample with a FR concentration of 100ppm ranged from <1 to >1000 particles. The presence of rare, high-concentration bromine particles was correlated with decabromodiphenyl ether concentrations obtained via GC-MS. When FRs are distributed heterogeneously in highly concentrated dust particles, human exposure to FRs may be characterized by high transient exposures interspersed by periods of low exposure, and GC-MS FR concentrations may exhibit large variability in replicate subsamples. Current limitations of this SEM/EDS technique include potential false negatives for volatile and chlorinated FRs and greater quantitation uncertainty for brominated FR in aluminum-rich matrices. Copyright © 2013 Elsevier Ltd. All rights reserved.

Copy number and haplotype variation at the VRN-A1 and central FR-A2 loci are associated with frost tolerance in hexaploid wheat.

PubMed

Zhu, Jie; Pearce, Stephen; Burke, Adrienne; See, Deven Robert; Skinner, Daniel Z; Dubcovsky, Jorge; Garland-Campbell, Kimberly

2014-05-01

The interaction between VRN - A1 and FR - A2 largely affect the frost tolerance of hexaploid wheat. Frost tolerance is critical for wheat survival during cold winters. Natural variation for this trait is mainly associated with allelic differences at the VERNALIZATION 1 (VRN1) and FROST RESISTANCE 2 (FR2) loci. VRN1 regulates the transition between vegetative and reproductive stages and FR2, a locus including several tandemly duplicated C-REPEAT BINDING FACTOR (CBF) transcription factors, regulates the expression of Cold-regulated genes. We identified sequence and copy number variation at these two loci among winter and spring wheat varieties and characterized their association with frost tolerance. We identified two FR-A2 haplotypes-'FR-A2-S' and 'FR-A2-T'-distinguished by two insertion/deletions and ten single nucleotide polymorphisms within the CBF-A12 and CBF-A15 genes. Increased copy number of CBF-A14 was frequently associated with the FR-A2-T haplotype and with higher CBF14 transcript levels in response to cold. Factorial ANOVAs revealed significant interactions between VRN1 and FR-A2 for frost tolerance in both winter and spring panels suggesting a crosstalk between vernalization and cold acclimation pathways. The model including these two loci and their interaction explained 32.0 and 20.7 % of the variation in frost tolerance in the winter and spring panels, respectively. The interaction was validated in a winter wheat F 4:5 population segregating for both genes. Increased VRN-A1 copy number was associated with improved frost tolerance among varieties carrying the FR-A2-T allele but not among those carrying the FR-A2-S allele. These results suggest that selection of varieties carrying the FR-A2-T allele and three copies of the recessive vrn-A1 allele would be a good strategy to improve frost tolerance in wheat.

Initial experience with the 3.3 Fr Mongoose® pigtail catheter for aortic angiography during patent ductus arteriosus closure in small patients

PubMed Central

Hena, Zachary; Sutton, Nicole J; Gates, Gregory J; Taragin, Benjamin H; Pass, Robert H

2017-01-01

Background: Smaller femoral arterial sheaths may be associated with fewer vascular complications. The 3.3 Fr Mongoose® Pediavascular pigtail catheter is a catheter that allows higher flow rates, potentially resulting in improved angiographic quality. We reviewed our experience with this small catheter during patent ductus arteriosus (PDA) closure. Materials and Methods: Review of patients ≤20 kg in whom the Mongoose® catheter was used during PDA closure from 12/13 to 4/15. Angiographic efficacy and procedural details were compared to ten 4 Fr catheter cases. Comparisons were performed using Mann–Whitney U-test; P < 0.05 was statistically significant. Results: Twelve (9 female) patients were catheterized with a 3.3 Fr Mongoose®. Median weight 10.5 kg (range 6.4–18.2), height 81 cm (range 37–111), and body surface area (BSA) 0.47 m2 (range 0.33–0.75) were similar to ten patients (3 females) in the 4 Fr control group (P = NS); median weight 9.9 kg (range 6–16.8), height 80 cm (range 64–102), and BSA 0.46 m2 (range 0.31–0.74). Angiographic quality was subjectively adequate with both with no difference in the median pixel density between the two techniques (3.3 Fr: 76.7 [range 33.5–90] and 4 Fr: [70; 38–102]; P = NS). Contrast used was similar between the groups (3.3 Fr: median 4.2 ml/kg and 4 Fr: 4.9 ml/kg; P = NS). Median radiation dose was similar in the two groups (3.3 Fr: 28.1 mGy [range 17.2–38] and 4 Fr: 38 mGy [range 20.4–58.5]; P = NS). All ducts were closed at latest follow-up (P = NS). No complications were encountered. Conclusions: The 3.3 Fr Mongoose® allowed similar angiography to the 4 Fr pigtail catheter, allowing safe and effective transcatheter PDA closure in small children. PMID:28928609

Ethanol production from a biomass mixture of furfural residues with green liquor-peroxide saccarified cassava liquid.

PubMed

Ji, Li; Zheng, Tianran; Zhao, Pengxiang; Zhang, Weiming; Jiang, Jianxin

2016-06-01

As the most abundant renewable resources, lignocellulosic materials are ideal candidates as alternative feedstock for bioethanol production. Cassava residues (CR) are byproducts of the cassava starch industry which can be mixed with lignocellulosic materials for ethanol production. The presence of lignin in lignocellulosic substrates can inhibit saccharification by reducing the cellulase activity. Simultaneous saccharification and fermentation (SSF) of furfural residues (FR) pretreated with green liquor and hydrogen peroxide (GL-H2O2) with CR saccharification liquid was investigated. The final ethanol concentration, yield, initial rate, number of live yeast cells, and the dead yeast ratio were compared to evaluate the effectiveness of combining delignificated lignocellulosic substrates and starchy substrates for ethanol production. Our results indicate that 42.0 % of FR lignin removal was achieved on FR using of 0.06 g H2O2/g-substrate and 9 mL GL/g-substrate at 80 °C. The highest overall ethanol yield was 93.6 % of the theoretical. When the ratio of 0.06 g/g-H2O2-GL-pretreated FR to CR was 5:1, the ethanol concentration was the same with that ratio of untreated FR to CR of 1:1. Using 0.06 g/g-H2O2-GL-pretreated FR with CR at a ratio of 2:1 resulted in 51.9 g/L ethanol concentration. Moreover, FR pretreated with GL-H2O2 decreased the concentration of byproducts in SSF compared with that obtained in the previous study. The lignin in FR would inhibit enzyme activity and GL-H2O2 is an advantageous pretreatment method to treat FR and high intensity of FR pretreatment increased the final ethanol concentration. The efficiency of ethanol fermentation of was improved when delignification increased. GL-H2O2 is an advantageous pretreatment method to treat FR. As the pretreatment dosage of GL-H2O2 on FR increased, the proportion of lignocellulosic substrates was enhanced in the SSF of the substrate mixture of CR and FR as compared with untreated FR. Moreover, the final ethanol concentration was increased with a high ethanol yield and lower byproduct concentrations.

Mapping cell populations in flow cytometry data for cross-sample comparison using the Friedman-Rafsky test statistic as a distance measure.

PubMed

Hsiao, Chiaowen; Liu, Mengya; Stanton, Rick; McGee, Monnie; Qian, Yu; Scheuermann, Richard H

2016-01-01

Flow cytometry (FCM) is a fluorescence-based single-cell experimental technology that is routinely applied in biomedical research for identifying cellular biomarkers of normal physiological responses and abnormal disease states. While many computational methods have been developed that focus on identifying cell populations in individual FCM samples, very few have addressed how the identified cell populations can be matched across samples for comparative analysis. This article presents FlowMap-FR, a novel method for cell population mapping across FCM samples. FlowMap-FR is based on the Friedman-Rafsky nonparametric test statistic (FR statistic), which quantifies the equivalence of multivariate distributions. As applied to FCM data by FlowMap-FR, the FR statistic objectively quantifies the similarity between cell populations based on the shapes, sizes, and positions of fluorescence data distributions in the multidimensional feature space. To test and evaluate the performance of FlowMap-FR, we simulated the kinds of biological and technical sample variations that are commonly observed in FCM data. The results show that FlowMap-FR is able to effectively identify equivalent cell populations between samples under scenarios of proportion differences and modest position shifts. As a statistical test, FlowMap-FR can be used to determine whether the expression of a cellular marker is statistically different between two cell populations, suggesting candidates for new cellular phenotypes by providing an objective statistical measure. In addition, FlowMap-FR can indicate situations in which inappropriate splitting or merging of cell populations has occurred during gating procedures. We compared the FR statistic with the symmetric version of Kullback-Leibler divergence measure used in a previous population matching method with both simulated and real data. The FR statistic outperforms the symmetric version of KL-distance in distinguishing equivalent from nonequivalent cell populations. FlowMap-FR was also employed as a distance metric to match cell populations delineated by manual gating across 30 FCM samples from a benchmark FlowCAP data set. An F-measure of 0.88 was obtained, indicating high precision and recall of the FR-based population matching results. FlowMap-FR has been implemented as a standalone R/Bioconductor package so that it can be easily incorporated into current FCM data analytical workflows. © The Authors. Published by Wiley Periodicals, Inc. on behalf of ISAC.

78 FR 56633 - Approval and Promulgation of Air Quality Implementation Plans; New York; Determination of Clean...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-13

... standard in Coso Junction, California), and 75 FR 6571 (February 10, 2010) (the determination of attainment..., 2007) (Miami, Arizona area); 75 FR 27944 (May 19, 2010) (Coso Junction, California area); and 76 FR... Coso Junction areas in California, make clear that the same reasoning applies to the PM 10 provisions...

48 CFR 252.247-7011 - Period of contract.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) for 180 days past the expiration date. (End of clause) [56 FR 36479, July 31, 1991, as amended at 66 FR 49861, Oct. 1, 2001] [56 FR 36479, July 31, 1991, as amended at 75 FR 51418, Aug. 20, 2010] ... clause: Period of Contract (OCT 2001) (a) This contract begins January 1, __, and ends December 31...

48 CFR 252.247-7011 - Period of contract.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) for 180 days past the expiration date. (End of clause) [56 FR 36479, July 31, 1991, as amended at 66 FR 49861, Oct. 1, 2001] [56 FR 36479, July 31, 1991, as amended at 75 FR 51418, Aug. 20, 2010] ... clause: Period of Contract (OCT 2001) (a) This contract begins January 1, __, and ends December 31...

27 CFR 71.117 - Permit privileges, exceptions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... force and effect except that, in the case of industrial use permits, any time after a citation has been... withdrawal permit. [T.D. 6389, 24 FR 4791, June 12, 1959. Redesignated at 40 FR 16835, Apr. 15, 1975; T.D. ATF-199, 50 FR 9197, Mar. 6, 1985; T.D. ATF-374, 61 FR 29957, June 13, 1996] ...

19 CFR 112.26 - Duration of license.

Code of Federal Regulations, 2011 CFR

2011-04-01

... license issued in accordance with this subpart shall remain in force and effect until the license is... this chapter. [T.D. 76-324, 41 FR 50822, Nov. 18, 1976, as amended by T.D. 84-213, 49 FR 41171, Oct. 19, 1984; 49 FR 44867, Nov. 9, 1984; T.D. 97-82, 62 FR 51770, Oct. 3, 1997] ...

19 CFR 112.26 - Duration of license.

Code of Federal Regulations, 2010 CFR

2010-04-01

... license issued in accordance with this subpart shall remain in force and effect until the license is... this chapter. [T.D. 76-324, 41 FR 50822, Nov. 18, 1976, as amended by T.D. 84-213, 49 FR 41171, Oct. 19, 1984; 49 FR 44867, Nov. 9, 1984; T.D. 97-82, 62 FR 51770, Oct. 3, 1997] ...

27 CFR 71.117 - Permit privileges, exceptions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... force and effect except that, in the case of industrial use permits, any time after a citation has been... withdrawal permit. [T.D. 6389, 24 FR 4791, June 12, 1959. Redesignated at 40 FR 16835, Apr. 15, 1975; T.D. ATF-199, 50 FR 9197, Mar. 6, 1985; T.D. ATF-374, 61 FR 29957, June 13, 1996] ...

78 FR 60379 - Board of Veterans Appeals, Voice of the Veteran Appellant Surveys; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-01

... collection notice in a Federal Register on September 6, 2013 (78 FR 54956), that contained errors. VA... 20420, at (202) 632-7492 or [email protected] . Correction In FR Doc. 2013-21699, published on September 6, 2013, at 78 FR 54956, make the following corrections. On page 54956, in the third column, at...

75 FR 10438 - Effluent Limitations Guidelines and Standards for the Construction and Development Point Source...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-08

... CONTACT: Mr. Jesse W. Pritts at 202-566-1038 ( [email protected] ). SUPPLEMENTARY INFORMATION... Executive Order 13084. 63 FR 27655 (May 10, 1998). This rule will not have substantial direct effects on the.... 64 FR 43255 (August 10, 1999). This rule also is not subject to Executive Order 13045, 62 FR 19885...

77 FR 73523 - HUD Acquisition Regulations (HUDAR)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-10

... authorization in FAR 1.301. HUDAR was last revised by final rule published on January 13, 2006 (71 FR 2432). II. Public Comments The proposed rule was published on March 16, 2012 (77 FR 15681), and the public comment... corrections) the proposed amendments to the HUDAR, made by proposed rule published on March 16, 2012 (77 FR...

42 CFR 412.84 - Payment for extraordinarily high-cost cases (cost outliers).

Code of Federal Regulations, 2014 CFR

2014-10-01

... request additional payment— (1) With initial submission of the bill; or (2) Within 60 days of receipt of the intermediary's initial determination. (c) Except as specified in paragraph (e) of this section, an.... 3, 1985; 51 FR 31496, Sept. 3, 1986; 53 FR 38529, Sept. 30, 1988; 54 FR 36494, Sept. 1, 1989; 55 FR...

78 FR 2397 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-11

...--Division of Research and Statistics, Board of Governors of the Federal Reserve System, Washington, DC 20551... Report of Specific Issues (FR 2004SI), Daily Report of Specific Issues (FR 2004SD), Supplement to the Daily Report of Specific Issues (FR 2004SD ad hoc), and Daily Report of Dealer Activity in Treasury...

76 FR 56708 - Ohio: Final Authorization of State Hazardous Waste Management Program Revision

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-14

.... January 4, 1989, 54 FR 246.... NESHAPS: Final Standards for May 14, 2001, 66 FR 24270..... OAC 3745-50-41...; Checklist 188.1. NESHAPS: Interim Standards for February 13, 2002, 67 FR 6792. OAC 3745-50-44; 3745-50-66... Waste Combustors 2009. (Interim Standards Rule); Checklist 197. NESHAPS: Standards for Hazardous...

50 CFR 223.102 - Enumeration of threatened marine and anadromous species.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., Panama, Venezuela and all the islands of the West Indies. 71 FR 26852, May 9, 2006 73 FR 72210, Nov. 26..., Honduras, Mexico, Nicaragua, Panama, Venezuela and all the islands of the West Indies. 71 FR 26852, May 9... segments (DPSs) (for a policy statement, see 61 FR 4722, February 7, 1996), and evolutionarily significant...

Exploring plane-symmetric solutions in f(R) gravity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shamir, M. F., E-mail: farasat.shamir@nu.edu.pk

2016-02-15

The modified theories of gravity, especially the f(R) gravity, have attracted much attention in the last decade. This paper is devoted to exploring plane-symmetric solutions in the context of metric f(R) gravity. We extend the work on static plane-symmetric vacuum solutions in f(R) gravity already available in the literature [1, 2]. The modified field equations are solved using the assumptions of both constant and nonconstant scalar curvature. Some well-known solutions are recovered with power-law and logarithmic forms of f(R) models.

Use of Modal Acoustic Emission to Monitor Damage Progression in Carbon Fiber/Epoxy Tows and Implications for Composite Structures

NASA Technical Reports Server (NTRS)

Waller, Jess M.; Saulsberry, Regor L.; Lucero, Ralph; Nichols, Charles T.; Wentzel, Daniel J.

2010-01-01

ASTM-based ILH methods were found to give a reproducible, quantitative estimate of the stress threshold at which significant accumulated damage began to occur. a) FR events are low energy (<2 V(exp 20 microsec) b) FR events occur close to the observed failure locus. c) FR events consist of more than 30% fiber breakage (>300 kHz) d) FR events show a consistent hierarchy of cooperative damage for composite tow, and for the COPV tested, regardless of applied load. Application of ILH or related stress profiles could lead to robust pass/fail acceptance criteria based on the FR. Initial application of FR and FFT analysis of AE data acquired on COPVs is promising.

78 FR 55225 - Determination of Attainment for the Chico Nonattainment Area for the 2006 Fine Particle Standard...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-10

...); and 75 FR 27944 (May 19, 2010) (Coso Junction, California area). Thus EPA has established that, under... Office of Management and Budget under Executive Order 12866 (58 FR 51735, October 4, 1993); Does not... based on health or safety risks subject to Executive Order 13045 (62 FR 19885, April 23, 1997); Is not a...

Parental Literacy Predicts Children's Literacy: A Longitudinal Family-Risk Study

ERIC Educational Resources Information Center

Torppa, Minna; Eklund, Kenneth; van Bergen, Elsje; Lyytinen, Heikki

2011-01-01

This family-risk (FR) study examined whether the literacy skills of parents with dyslexia are predictive of the literacy skills of their offspring. We report data from 31 child-parent dyads where both had dyslexia (FR-D) and 68 dyads where the child did not have dyslexia (FR-ND). Findings supported the differences in liability of FR children with…

40 CFR 52.2020 - Identification of plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) Compliance and test methods 11/1/97 6/8/98, 63 FR 31116 (c)(131). Subchapter D—Motor Vehicle Emissions.../02 12/8/04, 69 FR 70893 (c)(229). Section 130.108 Test procedures 10/5/02 12/8/04, 69 FR 70893 (c....414 Modification of variance 10/11/08 10/18/10, 75 FR 63717. TEST METHODS Section 130.431 Testing for...

19 CFR 207.7 - Limited disclosure of certain business proprietary information under administrative protective...

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 3 2014-04-01 2014-04-01 false Limited disclosure of certain business proprietary... order, and file with the Secretary a certificate attesting to his personal, good faith belief that all..., 1994; 61 FR 37829, July 22, 1996; 68 FR 32978, June 3, 2003; 70 FR 8512, Feb. 22, 2005; 76 FR 61942...

19 CFR 207.7 - Limited disclosure of certain business proprietary information under administrative protective...

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 3 2012-04-01 2012-04-01 false Limited disclosure of certain business proprietary... order, and file with the Secretary a certificate attesting to his personal, good faith belief that all..., 1994; 61 FR 37829, July 22, 1996; 68 FR 32978, June 3, 2003; 70 FR 8512, Feb. 22, 2005; 76 FR 61942...

19 CFR 207.7 - Limited disclosure of certain business proprietary information under administrative protective...

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 3 2013-04-01 2013-04-01 false Limited disclosure of certain business proprietary... order, and file with the Secretary a certificate attesting to his personal, good faith belief that all..., 1994; 61 FR 37829, July 22, 1996; 68 FR 32978, June 3, 2003; 70 FR 8512, Feb. 22, 2005; 76 FR 61942...

40 CFR 52.2420 - Identification of plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

.../19/11, 76 FR 3023 Removal of “Reasonably available control technology” from 5-40-250C. 5-40-260... Volatile Organic Compounds 4/17/95 4/21/00, 65 FR 21315 120-04-0503. 5-40-460 Control Technology Guidelines... 4/21/00, 65 FR 21315 120-04-0603. 5-40-610 Control Technology Guidelines 4/17/95 4/21/00, 65 FR...

40 CFR 52.1220 - Identification of plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 49303 7017.1135 Applicability 03/01/99 08/10/11, 76 FR 49303 7017.1140 CEMS design requirements 03/01/99... 7017.1190 COMS design requirements 03/01/99 08/10/11, 76 FR 49303 7017.1200 COMS monitoring data 03/01.../01/99 08/10/11, 76 FR 49303 7017.2030 Performance test pretest requirements 03/01/99 08/10/11, 76 FR...

40 CFR 52.1220 - Identification of plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 49303 7017.1135 Applicability 03/01/99 08/10/11, 76 FR 49303 7017.1140 CEMS design requirements 03/01/99... 7017.1190 COMS design requirements 03/01/99 08/10/11, 76 FR 49303 7017.1200 COMS monitoring data 03/01.../01/99 08/10/11, 76 FR 49303 7017.2030 Performance test pretest requirements 03/01/99 08/10/11, 76 FR...

40 CFR 52.1220 - Identification of plan.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 49303 7017.1135 Applicability 03/01/99 08/10/11, 76 FR 49303 7017.1140 CEMS design requirements 03/01/99... 7017.1190 COMS design requirements 03/01/99 08/10/11, 76 FR 49303 7017.1200 COMS monitoring data 03/01.../01/99 08/10/11, 76 FR 49303 7017.2030 Performance test pretest requirements 03/01/99 08/10/11, 76 FR...

75 FR 16179 - Notice of Affirmative Decisions on Petitions for Modification Granted in Whole or in Part

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-31

...-013-C FR Notice: 74 FR 27185 (June 8, 2009). Petitioner: Wolf Run Mining Company, Rt. 3, Box 146... FR 23745 (May 20, 2009). Petitioner: Excel Mining, LLC, Box 4126, State Highway 194 West, Pikeville... Heights, P.O. Box 1944, Superior, Arizona 85273. Mine: Resolution Copper Mine, MSHA I.D. No. 02-00152...

75 FR 4795 - Energy Conservation Program for Certain Industrial Equipment: Publication of the Petition for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-29

... 10, 2008) (Daikin waiver); 74 FR 15955 (April 8, 2009) (Daikin waiver); 74 FR 16193 (April 9, 2009) (Sanyo waiver); 74 FR 16373 (April 10, 2009) (Daikin waiver) The VRV-WIII systems have operational... water-source multi-split products on the basis of the existing test procedure under 10 CFR 431.96, which...

40 CFR 52.620 - Identification of plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

.../29/1982 08/18/1983, 48 FR 37403 11-60-18 Control of open burning 11/29/1982 08/18/1983, 48 FR 37403 11-60-19 Agricultural burning, permit requirement 11/29/1982 08/18/1983, 48 FR 37403 11-60-20 Agricultural burning, applications 11/29/1982 08/18/1983, 48 FR 37403 11-60-21 Agricultural burning, “no burn...

Watermelon germplasm lines USVL246-FR2 and USVL252-FR2 tolerant to fusarium oxysporum f. sp. niveum race 2

USDA-ARS?s Scientific Manuscript database

Two improved germplasm lines of wild watermelon (Citrullus lanatus var. citroides) designated USVL246-FR2 and USVL252-FR2 were released in 2012 by the Agricultural Research Service of the U.S. Department of Agriculture (Wechter et al. 2012). These lines are each highly uniform for growth characteri...

9 CFR 381.175 - Records required to be kept.

Code of Federal Regulations, 2011 CFR

2011-01-01

... slaughter. (b) The required records are: (1) Records, such as bills of sale, invoices, bills of lading, and... § 381.144. (3) Records of canning as required by subpart X of this part 381, of subchapter C, 9 CFR... 47 FR 746, Jan. 7, 1982; 49 FR 2236, Jan. 19, 1984; 51 FR 45633, Dec. 19, 1986; 57 FR 43600, Sept. 21...

9 CFR 381.175 - Records required to be kept.

Code of Federal Regulations, 2014 CFR

2014-01-01

... are: (1) Records, such as bills of sale, invoices, bills of lading, and receiving and shipping papers... by subpart X of this part 381, of subchapter C, 9 CFR chapter III. (4) Records of irradiation as..., Jan. 19, 1984; 51 FR 45633, Dec. 19, 1986; 57 FR 43600, Sept. 21, 1992; 58 FR 675, Jan. 6, 1993; 60 FR...

18 CFR 2.1 - Initial notice; service; and information copies of formal documents.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Initial notice; service; and information copies of formal documents. 2.1 Section 2.1 Conservation of Power and Water Resources... Order 463, 37 FR 28054, Dec. 20, 1972; 38 FR 3192, Feb. 2, 1973; 44 FR 34941, June 18, 1979; 45 FR 21224...

18 CFR 2.1 - Initial notice; service; and information copies of formal documents.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Initial notice; service; and information copies of formal documents. 2.1 Section 2.1 Conservation of Power and Water Resources...; 38 FR 3192, Feb. 2, 1973; 44 FR 34941, June 18, 1979; 45 FR 21224, Apr. 1, 1980; Order 541, 57 FR...

18 CFR 2.1 - Initial notice; service; and information copies of formal documents.

Code of Federal Regulations, 2014 CFR

2014-04-01

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Interaction of reinforcement schedules, a behavioral prosthesis, and work-related behavior in adults with mental retardation.

PubMed

Saunders, Richard R; McEntee, Julie E; Saunders, Muriel D

2005-01-01

The effects of variable-interval (VI) and fixed-ratio (FR) schedules of reinforcement for work-related behavior and an organizer for the work materials (behavioral prosthesis) were evaluated with 3 adults with severe or profound mental retardation. The participants had been recommended for study because of high rates of off-task and aberrant behavior in their daily vocational training programs. For 2 participants, VI and FR schedules resulted in the same outcome: more aberrant behavior than on-task and off-task behavior combined. The FR schedule nearly eliminated emission of aberrant and off-task behavior by the 3rd participant. Combining the behavioral prosthesis with FR reinforcement (FR+O) increased the proportion of time spent in on-task behavior by all participants under certain FR schedule parameters. Second-by-second analyses of the observation records revealed that FR schedules reduced off-task and aberrant behavior during work sequences (i.e., ratio runs), and FR+O led to a further reduction of these behaviors during postreinforcement pauses. Overall, the results show how organizer and schedule parameters can be adjusted to produce an optimized balance between productivity and reinforcement while undesirable behavior is minimized.

Intricacies of cosmological bounce in polynomial metric f(R) gravity for flat FLRW spacetime

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhattacharya, Kaushik; Chakrabarty, Saikat, E-mail: kaushikb@iitk.ac.in, E-mail: snilch@iitk.ac.in

2016-02-01

In this paper we present the techniques for computing cosmological bounces in polynomial f(R) theories, whose order is more than two, for spatially flat FLRW spacetime. In these cases the conformally connected Einstein frame shows up multiple scalar potentials predicting various possibilities of cosmological evolution in the Jordan frame where the f(R) theory lives. We present a reasonable way in which one can associate the various possible potentials in the Einstein frame, for cubic f(R) gravity, to the cosmological development in the Jordan frame. The issue concerning the energy conditions in f(R) theories is presented. We also point out themore » very important relationships between the conformal transformations connecting the Jordan frame and the Einstein frame and the various instabilities of f(R) theory. All the calculations are done for cubic f(R) gravity but we hope the results are sufficiently general for higher order polynomial gravity.« less

Large-scale magnetic topologies of early M dwarfs

NASA Astrophysics Data System (ADS)

Donati, J.-F.; Morin, J.; Petit, P.; Delfosse, X.; Forveille, T.; Aurière, M.; Cabanac, R.; Dintrans, B.; Fares, R.; Gastine, T.; Jardine, M. M.; Lignières, F.; Paletou, F.; Ramirez Velez, J. C.; Théado, S.

2008-10-01

We present here additional results of a spectropolarimetric survey of a small sample of stars ranging from spectral type M0 to M8 aimed at investigating observationally how dynamo processes operate in stars on both sides of the full convection threshold (spectral type M4). The present paper focuses on early M stars (M0-M3), that is above the full convection threshold. Applying tomographic imaging techniques to time series of rotationally modulated circularly polarized profiles collected with the NARVAL spectropolarimeter, we determine the rotation period and reconstruct the large-scale magnetic topologies of six early M dwarfs. We find that early-M stars preferentially host large-scale fields with dominantly toroidal and non-axisymmetric poloidal configurations, along with significant differential rotation (and long-term variability); only the lowest-mass star of our subsample is found to host an almost fully poloidal, mainly axisymmetric large-scale field resembling those found in mid-M dwarfs. This abrupt change in the large-scale magnetic topologies of M dwarfs (occurring at spectral type M3) has no related signature on X-ray luminosities (measuring the total amount of magnetic flux); it thus suggests that underlying dynamo processes become more efficient at producing large-scale fields (despite producing the same flux) at spectral types later than M3. We suspect that this change relates to the rapid decrease in the radiative cores of low-mass stars and to the simultaneous sharp increase of the convective turnover times (with decreasing stellar mass) that models predict to occur at M3; it may also be (at least partly) responsible for the reduced magnetic braking reported for fully convective stars. Based on observations obtained at the Télescope Bernard Lyot (TBL), operated by the Institut National des Science de l'Univers of the Centre National de la Recherche Scientifique of France. E-mail: donati@ast.obs-mip.fr (J-FD); jmorin@ast.obs-mip.fr (JM); petit@ast.obs-mip.fr (PP); xavier.delfosse@obs.ujf-grenoble.fr (XD); thierry.forveille@obs.ujf-grenoble.fr (TF); auriere@ast.obs-mip.fr (MA); remi.cabanac@ast.obs-mip.fr (RC); dintrans@ast.obs-mip.fr (BD); rfares@ast.obs-mip.fr (RF); tgastine@ast.obs-mip.fr (TG); mmj@st-and.ac.uk (MMJ); lignieres@ast.obs-mip.fr (FL); fpaletou@ast.obs-mip.fr (FP); julio.ramirez@obspm.fr (JCRV); sylvie.theado@ast.obs-mip.fr (ST)

Adrenaline and triiodothyronine modify the iron handling in the freshwater air-breathing fish Anabas testudineus Bloch: role of ferric reductase in iron acquisition.

PubMed

Rejitha, V; Peter, M C Subhash

2013-01-15

The effects of in vivo adrenaline and triiodothyronine (T(3)) on ferric reductase (FR) activity, a membrane-bound enzyme that reduces Fe(III) to Fe(II) iron, were studied in the organs of climbing perch (Anabas testudineus Bloch). Adrenaline injection (10 ng g(-1)) for 30 min produced significant inhibition of FR activity in the liver and kidney and that suggests a role for this stress hormone in iron acquisition in this fish. Short-term T(3) injection (40 ng g(-1)) reduced FR activity in the gills of fed fish but not in the unfed fish. Similar reduction of FR activity was also obtained in the intestine and kidney of fed fish after T(3) injection. Feeding produced pronounced decline in FR activity in the spleen but T(3) challenge in fed and unfed fish increased its activity in this iron storing organ and that point to the sensitivity of FR system to feeding activity. The in vitro effects of Fe on FR activity in the gill explants of freshwater fish showed correlations of FR with Na(+), K(+)-ATPase and H(+)-ATPase activities. Substantial increase in the FR activity was found in the gill explants incubated with all the tested doses of Fe(II) iron (1.80, 3.59 and 7.18 μM) and Fe(III) iron (1.25, 2.51 and 5.02 μM) and this indicate that FR and Na pump activity are positively correlated. On the contrary, substantial reduction of gill H(+)-ATPase activity was found in the gill explants incubated with Fe(II) iron and Fe(III) iron indicating that perch gills may not require a high acidic microenvironment for the reduction of Fe(III) iron. Accumulation of iron in the gill explants after Fe(III) iron incubation implies a direct relationship between Fe acquisition and FR activity in this tissue. The inverse correlation between FR activity and H(+)-ATPase activity in Fe(II) or Fe(III) loaded gills and the significant positive correlations of FR activity with total [Fe] content in the Fe(III) loaded gills substantiate that FR which shows sensitivity to sodium and proton pumps, has a vital role in Fe(II) and Fe(III) iron handling in this fish. Our data also provide evidence that adrenaline, T(3) and the feeding status are the vital factors that can regulate the storage and handling of iron in fish. Copyright © 2012 Elsevier Inc. All rights reserved.

Mapping cell populations in flow cytometry data for cross‐sample comparison using the Friedman–Rafsky test statistic as a distance measure

PubMed Central

Hsiao, Chiaowen; Liu, Mengya; Stanton, Rick; McGee, Monnie; Qian, Yu

2015-01-01

Abstract Flow cytometry (FCM) is a fluorescence‐based single‐cell experimental technology that is routinely applied in biomedical research for identifying cellular biomarkers of normal physiological responses and abnormal disease states. While many computational methods have been developed that focus on identifying cell populations in individual FCM samples, very few have addressed how the identified cell populations can be matched across samples for comparative analysis. This article presents FlowMap‐FR, a novel method for cell population mapping across FCM samples. FlowMap‐FR is based on the Friedman–Rafsky nonparametric test statistic (FR statistic), which quantifies the equivalence of multivariate distributions. As applied to FCM data by FlowMap‐FR, the FR statistic objectively quantifies the similarity between cell populations based on the shapes, sizes, and positions of fluorescence data distributions in the multidimensional feature space. To test and evaluate the performance of FlowMap‐FR, we simulated the kinds of biological and technical sample variations that are commonly observed in FCM data. The results show that FlowMap‐FR is able to effectively identify equivalent cell populations between samples under scenarios of proportion differences and modest position shifts. As a statistical test, FlowMap‐FR can be used to determine whether the expression of a cellular marker is statistically different between two cell populations, suggesting candidates for new cellular phenotypes by providing an objective statistical measure. In addition, FlowMap‐FR can indicate situations in which inappropriate splitting or merging of cell populations has occurred during gating procedures. We compared the FR statistic with the symmetric version of Kullback–Leibler divergence measure used in a previous population matching method with both simulated and real data. The FR statistic outperforms the symmetric version of KL‐distance in distinguishing equivalent from nonequivalent cell populations. FlowMap‐FR was also employed as a distance metric to match cell populations delineated by manual gating across 30 FCM samples from a benchmark FlowCAP data set. An F‐measure of 0.88 was obtained, indicating high precision and recall of the FR‐based population matching results. FlowMap‐FR has been implemented as a standalone R/Bioconductor package so that it can be easily incorporated into current FCM data analytical workflows. © 2015 International Society for Advancement of Cytometry PMID:26274018

A novel urinary long non-coding RNA transcript improves diagnostic accuracy in patients undergoing prostate biopsy.

PubMed

Zhang, Wei; Ren, Shan-Cheng; Shi, Xiao-Lei; Liu, Ya-Wei; Zhu, Ya-Sheng; Jing, Tai-Le; Wang, Fu-Bo; Chen, Rui; Xu, Chuan-Liang; Wang, Hui-Qing; Wang, Hai-Feng; Wang, Yan; Liu, Bing; Li, Yao-Ming; Fang, Zi-Yu; Guo, Fei; Lu, Xin; Shen, Dan; Gao, Xu; Hou, Jian-Guo; Sun, Ying-Hao

2015-05-01

Long non-coding RNA (LncRNA) PCA3 has been a well-established urine biomarker for the detection of prostate cancer (PCa). Our previous study showed a novel LncRNA FR0348383 is up-regulated in over 70% of PCa compared with matched benign tissues. The aim of this study was to evaluate the diagnostic value of urinary FR0348383 for men undergoing prostate biopsy due to elevated PSA (PSA > 4.0 ng/ml) and/or abnormal digital rectal examination (DRE). Post-DRE first-catch urine specimens prior to prostate biopsies were prospectively collected. After the whole transcriptome amplification, quantitative real time polymerase chain reaction was applied to quantify urine FR0348383 and PSA levels. The FR0348383 score was calculated as the ratio of PSA and FR0348383 mRNA (PSA mRNA/FR0348383 mRNA × 1000). The diagnostic value of FR0348383 score was evaluated by logistic regression and decision curve analysis. 213 cases with urine samples containing sufficient mRNA were included, 94 cases had serum PSA level 4.0-10.0 ng/ml. PCa was identified in 72 cases. An increasing FR0348383 score was correlated with an increasing probability of a positive biopsy (P < 0.001). Multivariable logistic analysis indicated FR0348383 score (P < 0.001), PSA (P = 0.004), age (P = 0.007), prostate volume (P < 0.001) were independent predictors of PCa. ROC analysis demonstrated FR0348383 score outperformed PSA, %free PSA, and PSA Density in the prediction of PCa in the subgroup of patients with grey area PSA (AUC: 0.815 vs. 0.562 vs. 0.599 vs. 0.645). When using a probability threshold of 30% in the grey zone cohort, The FR0348383 score would save 52.0% of avoidable biopsies without missing any high grade cancers. FR0348383 transcript in post-DRE urine may be a novel biomarker for detection of PCa with great diagnostic value, especially in the grey zone cohort. The application of FR0348383 score in clinical practice might avoid unnecessary prostate biopsies and increase the specificity of PCa diagnosis. © 2015 Wiley Periodicals, Inc.

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Low Transvalvular Flow Rate Predicts Mortality in Patients With Low-Gradient Aortic Stenosis Following Aortic Valve Intervention.

PubMed

Vamvakidou, Anastasia; Jin, Wenying; Danylenko, Oleksandr; Chahal, Navtej; Khattar, Rajdeep; Senior, Roxy

2018-03-09

This study aimed to assess the value of low transvalvular flow rate (FR) for the prediction of mortality compared with low stroke volume index (SVi) in patients with low-gradient (mean gradient: <40 mm Hg), low aortic valve area (<1 cm 2 ) aortic stenosis (AS) following aortic valve intervention. Transaortic FR defined as stroke volume/left ventricular ejection time is also a marker of flow; however, no data exist comparing the relative prognostic value of these 2 transvalvular flow markers in patients with low-gradient AS who had undergone valve intervention. We retrospectively followed prospectively assessed consecutive patients with low-gradient, low aortic valve area AS who underwent aortic valve intervention between 2010 and 2014 for all-cause mortality. Of the 218 patients with mean age 75 ± 12 years, 102 (46.8%) had low stroke volume index (SVi) (<35 ml/m 2 ), 95 (43.6%) had low FR (<200 ml/s), and 58 (26.6%) had low left ventricular ejection fraction <50%. The concordance between FR and SVi was 78.8% (p < 0.005). Over a median follow-up of 46.8 ± 21 months, 52 (23.9%) deaths occurred. Patients with low FR had significantly worse outcome compared with those with normal FR (p < 0.005). In patients with low SVi, a low FR conferred a worse outcome than a normal FR (p = 0.005), but FR status did not discriminate outcome in patients with normal SVi. By contrast, SVi did not discriminate survival either in patients with normal or low FR. Low FR was an independent predictor of mortality (p = 0.013) after adjusting for age, clinical prognostic factors, European System for Cardiac Operative Risk Evaluation II, dimensionless velocity index, left ventricular mass index, left ventricular ejection fraction, heart rate, time, type of aortic valve intervention, and SVi (p = 0.59). In patients with low-gradient, low valve area aortic stenosis undergoing aortic valve intervention, low FR, not low SVi, was an independent predictor of medium-term mortality. Copyright © 2018 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

The impact of tissue Doppler index E/e' ratio on instantaneous wave-free ratio.

PubMed

Arashi, Hiroyuki; Yamaguchi, Junichi; Ri, Tonre; Otsuki, Hisao; Nakao, Masashi; Kamishima, Kazuho; Jujo, Kentaro; Minami, Yuichiro; Ogawa, Hiroshi; Hagiwara, Nobuhisa

2018-03-01

The instantaneous wave-free ratio (iFR) is a vasodilator-free, invasive pressure wire index of the functional severity of coronary stenosis and is calculated under resting conditions. In a recent study, iFR was found to be more closely linked to coronary flow reserve (CFR) than fractional flow reserve (FFR). E/e' is a surrogate marker of left ventricular (LV) filling pressure and LV diastolic dysfunction. Coronary resting flow was found to be increased in patients with elevated E/e', and higher coronary resting flow was associated with lower CFR. Higher baseline coronary flow induces a greater loss of translesional pressure and may affect iFR. However, no reports have examined the impact of E/e' on iFR. The purpose of this study was to assess the relationship between iFR and E/e' compared with FFR. We retrospectively examined 103 consecutive patients (142 with stenosis) whose iFR, FFR, and E/e' were measured simultaneously. The mean age, LV mass index, and systolic blood pressure of patients with elevated E/e' were higher than those of patients with normal E/e'. Although no significant differences were observed in mean FFR values and % diameter stenosis, the mean iFR value in patients with elevated E/e' was significantly lower than that in patients with normal E/e'. The iFR was negatively correlated with E/e', while there was no correlation between FFR and E/e'. Multivariate analysis showed that E/e' and % diameter stenosis were independent determinants of iFR. E/e' ratio affects iFR values. Our results suggest that FFR mainly reflects the functional severity of the epicardial stenosis whereas iFR could potentially be influenced by not only epicardial stenosis but also other factors related to LV filling pressure or LV diastolic dysfunction. Further research is needed to understand the underlying mechanisms that influence the evaluation of iFR in patients with elevated E/e'. Copyright © 2017 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

Real-time use of instantaneous wave-free ratio: results of the ADVISE in-practice: an international, multicenter evaluation of instantaneous wave-free ratio in clinical practice.

PubMed

Petraco, Ricardo; Al-Lamee, Rasha; Gotberg, Matthias; Sharp, Andrew; Hellig, Farrel; Nijjer, Sukhjinder S; Echavarria-Pinto, Mauro; van de Hoef, Tim P; Sen, Sayan; Tanaka, Nobuhiro; Van Belle, Eric; Bojara, Waldemar; Sakoda, Kunihiro; Mates, Martin; Indolfi, Ciro; De Rosa, Salvatore; Vrints, Christian J; Haine, Steven; Yokoi, Hiroyoshi; Ribichini, Flavio L; Meuwissen, Martjin; Matsuo, Hitoshi; Janssens, Luc; Katsumi, Ueno; Di Mario, Carlo; Escaned, Javier; Piek, Jan; Davies, Justin E

2014-11-01

To evaluate the first experience of real-time instantaneous wave-free ratio (iFR) measurement by clinicians. The iFR is a new vasodilator-free index of coronary stenosis severity, calculated as a trans-lesion pressure ratio during a specific period of baseline diastole, when distal resistance is lowest and stable. Because all previous studies have calculated iFR offline, the feasibility of real-time iFR measurement has never been assessed. Three hundred ninety-two stenoses with angiographically intermediate stenoses were included in this multicenter international analysis. Instantaneous wave-free ratio and fractional flow reserve (FFR) were performed in real time on commercially available consoles. The classification agreement of coronary stenoses between iFR and FFR was calculated. Instantaneous wave-free ratio and FFR maintain a close level of diagnostic agreement when both are measured by clinicians in real time (for a clinical 0.80 FFR cutoff: area under the receiver operating characteristic curve [ROC(AUC)] 0.87, classification match 80%, and optimal iFR cutoff 0.90; for a ischemic 0.75 FFR cutoff: iFR ROC(AUC) 0.90, classification match 88%, and optimal iFR cutoff 0.85; if the FFR 0.75-0.80 gray zone is accounted for: ROC(AUC) 0.93, classification match 92%). When iFR and FFR are evaluated together in a hybrid decision-making strategy, 61% of the population is spared from vasodilator while maintaining a 94% overall agreement with FFR lesion classification. When measured in real time, iFR maintains the close relationship to FFR reported in offline studies. These findings confirm the feasibility and reliability of real-time iFR calculation by clinicians. Copyright © 2014 The Author. Published by Elsevier Inc. All rights reserved.

Simplifying the assessment of coronary artery stenosis by enhancing instantaneous wave free ratio.

PubMed

Spagnoli, Vincent; Picard, Fabien; Tadros, Victor-Xavier; Cournoyer, Daniel; Doucet, Serge; Tanguay, Jean François; Gosselin, Gilbert; de Guise, Pierre; Gallo, Richard

2018-04-01

Instantaneous wave free ratio (iFR) does not require adenosine, but has a relatively wide intermediate range where functional assessment remains inconclusive. In this pilot study, we sought to enhance iFR through with the use of intracoronary (IC) saline (iFRs) and contrast media (iFRc) and determine whether these techniques correlated well with fractional flow reserve (FFR). Patients with coronary artery stenosis (CAS) associated with an iFR in the intermediate zone (≥0.86 and ≤0.93) were prospectively assessed with resting distal coronary pressure/aorta pressure (Pd/Pa), iFR, iFRs, iFRc and FFR. A total of 40 coronary lesions were studied (40 patients). Pearson correlation coefficients for FFR and iFR, FFR and iFRs, FFR and iFRc were respectively: 0.57 (P=0.0002), 0.80 (P<0.0001) and 0.77 (P<0.0001). Receiver-operating characteristic (ROC) curve analysis showed similar area under the curve (AUC) of iFRs and iFR [0.90 (95% CI: 0.76-1) vs. 0.89 (95% CI: 0.79-0.99), P=0.89]. Youden's index established cut-off values of ≤0.90 for iFR (sensitivity =91%, specificity =74%) and ≤0.78 for iFRs (sensitivity =73%, specificity =100%). In contrast, the AUC of iFRc was superior to the AUC of iFR [0.99 (95% CI: 0.98-1), P=0.049]. iFRc showed excellent accuracy and established cut-off values of ≤0.81 in predicting an FFR value of ≤0.80 (sensitivity =100%, specificity =93%). When iFR is in the intermediate zone, functional assessment of CAS by iFR is enhanced with the use of contrast media but not saline. This pilot study could be hypothesis generating for further study to enhance iFR specificity and sensibility.

Simplifying the assessment of coronary artery stenosis by enhancing instantaneous wave free ratio

PubMed Central

Spagnoli, Vincent; Picard, Fabien; Tadros, Victor-Xavier; Cournoyer, Daniel; Doucet, Serge; Tanguay, Jean François; Gosselin, Gilbert; de Guise, Pierre

2018-01-01

Background Instantaneous wave free ratio (iFR) does not require adenosine, but has a relatively wide intermediate range where functional assessment remains inconclusive. In this pilot study, we sought to enhance iFR through with the use of intracoronary (IC) saline (iFRs) and contrast media (iFRc) and determine whether these techniques correlated well with fractional flow reserve (FFR). Methods Patients with coronary artery stenosis (CAS) associated with an iFR in the intermediate zone (≥0.86 and ≤0.93) were prospectively assessed with resting distal coronary pressure/aorta pressure (Pd/Pa), iFR, iFRs, iFRc and FFR. Results A total of 40 coronary lesions were studied (40 patients). Pearson correlation coefficients for FFR and iFR, FFR and iFRs, FFR and iFRc were respectively: 0.57 (P=0.0002), 0.80 (P<0.0001) and 0.77 (P<0.0001). Receiver-operating characteristic (ROC) curve analysis showed similar area under the curve (AUC) of iFRs and iFR [0.90 (95% CI: 0.76–1) vs. 0.89 (95% CI: 0.79–0.99), P=0.89]. Youden’s index established cut-off values of ≤0.90 for iFR (sensitivity =91%, specificity =74%) and ≤0.78 for iFRs (sensitivity =73%, specificity =100%). In contrast, the AUC of iFRc was superior to the AUC of iFR [0.99 (95% CI: 0.98–1), P=0.049]. iFRc showed excellent accuracy and established cut-off values of ≤0.81 in predicting an FFR value of ≤0.80 (sensitivity =100%, specificity =93%). Conclusions When iFR is in the intermediate zone, functional assessment of CAS by iFR is enhanced with the use of contrast media but not saline. This pilot study could be hypothesis generating for further study to enhance iFR specificity and sensibility. PMID:29850406

Antibacterial, antioxidant, and topical anti-inflammatory activities of Bergia ammannioides: A wound-healing plant.

PubMed

Ezzat, Shahira M; Choucry, Mouchira A; Kandil, Zeinab A

2016-01-01

Despite the traditional use of Bergia ammannioides Henye ex Roth. (Elatinaceae) for the treatment of wounds in India, there is a scarcity of scientific data supporting this use. The objective of this study is to assess wound-healing potentiality of the plant, to study pharmacological activities that may contribute in eliminating wound complications, and to investigate the biologically active fractions. The ethanolic extract (EtOH) of the aerial parts was fractionated to obtain n-hexane (HxFr), chloroform (ClFr), ethyl acetate (EtFr), and n-butanol (BuOH) fractions. EtOH and its fractions were formulated in strength of 5 and 10% w/w ointment and tested for wound-healing activity using the excision model. The topical anti-inflammatory, in vitro antioxidant, and antibacterial activities were evaluated. HxFr and EtFr were chemically investigated to isolate their constituents. Application of EtOH, HxFr, and EtFr (10% w/w ointments) leads to 71.77, 85.62, and 81.29% healing of the wounds with an increase in the collagen content. HxFr had the strongest anti-inflammatory (64.5% potency relative to Voltaren®) and antibacterial activity (MIC = 104 μg/ml against Staphylococcus aureus), while EtFr showed the strongest antioxidant activity against DPPH, ABTS(•+), and super oxide radical with an IC50 value of 10.25 ± 0.01, 66.09 ± 0.76, and 167.33 ± 0.91 µg/ml, respectively. β-Sitosterol, lupeol, cyclolaudenol, and cycloartenol were isolated from HxFr. Quercetin, ellagic acid, kaempferol-3-O-α-l-rhamnoside, and quercetin-3-O-α-l-rhamnoside were isolated from EtFr. Our study presents scientific evidence for the efficacy of B. ammannioides in enhancing wound healing, and the first isolation of cyclolaudenol and cycloartenol from Bergia.

List of Participants

NASA Astrophysics Data System (ADS)

2011-09-01

AbeTakashiUniversity of Tokyotabe@nt.phys.s.u-tokyo.ac.jp AmusiaMironRacah Institute of Physics, Jerusalemamusia@vms.huji.ac.il BaldoMarcelloINFN Cataniabaldo@ct.infn.it BansalManiePanjab University, Chandigarhbansalmanni@gmail.com BarrancoFranciscoUniversity of Sevillebarranco@us.es BertschGeorgeUniversity of Washington, Seattlebertsch@u.washington.edu BhagwatAmeeyaCBS Mumbaiameeya@kth.se BorderieBernardIPN Orsayborderie@ipno.in2p3.fr CarbonellJaumeLPSC Grenoblejaume.carbonell@lpsc.in2p3.fr CarlsonJoeLos Alamos National Laboratorycarlson@lanl.gov ColòGianlucaINFN - Università degli Studi di Milanocolo@mi.infn.it DanielewiczPawelNSCL, Michigan State Universitydanielewicz@nscl.msu.edu DescouvemontPierreUniversité Libre de Bruxellespdesc@ulb.ac.be Dohet-EralyJérémyUniversité Libre de Bruxellesjdoheter@ulb.ac.be DraayerJerryLouisiana State Universitydraayer@lsu.edu DufourMarianneIPHC, Université de Strasbourgmarianne.dufour@ires.in2p3.fr DuguetThomasCEA Saclaythomas.duguet@cea.fr DukelskyJorgeCSIC Madriddukelsky@iem.cfmac.csic.es EbranJean-PaulCEA-DAM, Arpajonebran@ipno.in2p3.fr FreerMartinUniversity of Birminghamm.freer@bham.ac.uk FujiiShinichiroUniversity of Tokyosfujii@cns.s.u-tokyo.ac.jp FunakiYasuroRIKEN Nishina Center, Wakofunaki@riken.jp GrassoMarcellaIPN Orsaygrasso@ipno.in2p3.fr HaginoKouichiTohoku Universityhagino@nucl.phys.tohoku.ac.jp HansenHubertUniversité Claude Bernard Lyon 1hansen@ipnl.in2p3.fr HolzmannMarkusLPMMC Grenoblemarkus@lptl.jussieu.fr HoriuchiHisashiRCNP, Osaka Universityhoriuchi@rcnp.osaka-u.ac.jp HoriuchiWataruGSI Darmstadtw.horiuchi@gsi.de HupinGuillaumeGANIL, Caenhupin@ganil.fr JinMengHuazhong Normal University, Wuhanjinm@iopp.ccnu.edu.cn KamimuraMasayasuRIKEN Nishina Center, Wakomkamimura@riken.jp Kanada-En'yoYoshikoKyoto Universityyenyo@ruby.scphys.kyoto-u.ac.jp KatoKiyoshiHokkaido University, Sapporokato@nucl.sci.hokudai.ac.jp KawabataTakahiroKyoto Universitykawabata@scphys.kyoto-u.ac.jp KhanEliasIPN Orsaykhan@ipno.in2p3.fr KhodelVictorKurchatov Institute, Moscowvak@wuphys.wustl.edu KimuraMasaakiHokkaido University, Sapporomasaaki@nucl.sci.hokudai.ac.jp LacroixDenisGANIL, Caenlacroix@ganil.fr LiangHaozhaoPeking University, Beijinghzliang@pku.edu.cn MargueronJérômeIPN Orsayjerome.margueron@ipno.in2p3.fr MassotElisabethIPN Orsaymassot@ipno.in2p3.fr MengJiePeking University, Beijingmengj@pku.edu.cn MillerTomaszWarsaw University of Technologymillert@student.mini.pw.edu.pl MoghrabiKassemIPN Orsaymoghrabi@ipno.in2p3.fr NapolitaniPaoloIPN Orsaynapolita@ipno.in2p3.fr NeffThomasGSI Darmstadtt.neff@gsi.de NguyenVan GiaiIPN Orsaynguyen@ipno.in2p3.fr OtsukaTakaharuUniversity of Tokyootsuka@phys.s.u-tokyo.ac.jp PilletNathalie-MarieCEA-DAM, Arpajonnathalie.pillet@cea.fr QiChongKTH Stockholmchongq@kth.se RamananSunethraICTP Triestesramanan@ictp.it RingPeterTU Munichring@ph.tum.de Rios HuguetArnauUniversity of Surreya.rios@surrey.ac.uk RivetMarie-FranceIPN Orsayrivet@ipno.in2p3.fr RobledoLuisUniversidad Autonoma de Madridluis.robledo@uam.es Roca MazaXavierINFN Milanoxavier.roca.maza@mi.infn.it RöpkeGerdRostock Universitygerd.roepke@uni-rostock.de RowleyNeilIPN Orsayrowley@ipno.in2p3.fr SagawaHiroyukiUniversity of Aizusagawa@u-aizu.ac.jp SandulescuNicolaeIFIN-HH, Bucharestsandulescu@theory.nipne.ro SchuckPeterIPN Orsayschuck@ipno.in2p3.fr SedrakianArmenGoethe Universität Frankfurtsedrakian@th.physik.uni-frankfurt.de SeveryukhinAlexeyJINR Dubnasever@theor.jinr.ru SogoTakaakiIPN Orsaysogo@ipno.in2p3.fr SomàVittorioCEA Saclayvittorio.soma@cea.fr StrinatiGiancarloUniversità di Camerinogiancarlo.strinati@gmail.com SuharaTadahiroKyoto Universitysuhara@ruby.scphys.kyoto-u.ac.jp SukhoruchkinSergeiPetersburg Nuclear Physics Institutesergeis@pnpi.spb.ru SuzukiToruTokyo Metropolitan Universitysuzukitr@tmu.ac.jp SuzukiToshioNihon University, Tokyosuzuki@chs.nihon-u.ac.jp TarpanovDimitarINRNE, Sofiadimitert@yahoo.co.uk Tohsaki-SuzukiAkihiroOsaka Universitytohsaki@rcnp.osaka-u.ac.jp TypelStefanGSI Darmstadts.typel@gsi.de UesakaTomohiroUniversity of Tokyouesaka@cns.s.u-tokyo.ac.jp UrbanMichaelIPN Orsayurban@ipno.in2p3.fr Van IsackerPietGANIL Caenisacker@ganil.fr VigezziEnricoINFN Milanovigezzi@mi.infn.it ViñasXavierUniversitat de Barcelonaxavier@ecm.ub.es Vinh MauNicoleIPN Orsayvinhmau@ipno.in2p3.fr VitturiAndreaINFN Padovavitturi@pd.infn.it Von OertzenWolframHelmholtz Zentrum Berlinoertzen@helmholtz-berlin.de WambachJochenTechnische Universität Darmstadtjochen.wambach@physik.tu-darmstadt.de WlazłowskiGabrielWarsaw University of Technologygabrielw@if.pw.edu.pl YamadaTaiichiKanto Gakuin University, Yokohamayamada@kanto-gakuin.ac.jp YoshidaKenichiRIKEN Nishina Center, Wakokenichi.yoshida@riken.jp YoshidaSatoshiHosei University, Tokyos_yoshi@i.hosei.ac.jp

48 CFR 31.101 - Objectives.

Code of Federal Regulations, 2011 CFR

2011-10-01

.... Class deviations for the National Aeronautics and Space Administration require advance approval of the..., Technology, and Logistics. [48 FR 42301, Sept. 19, 1983, as amended at 56 FR 67133, Dec. 27, 1991; 61 FR...

48 CFR 31.101 - Objectives.

Code of Federal Regulations, 2013 CFR

2013-10-01

.... Class deviations for the National Aeronautics and Space Administration require advance approval of the..., Technology, and Logistics. [48 FR 42301, Sept. 19, 1983, as amended at 56 FR 67133, Dec. 27, 1991; 61 FR...

48 CFR 31.101 - Objectives.

Code of Federal Regulations, 2012 CFR

2012-10-01

.... Class deviations for the National Aeronautics and Space Administration require advance approval of the..., Technology, and Logistics. [48 FR 42301, Sept. 19, 1983, as amended at 56 FR 67133, Dec. 27, 1991; 61 FR...

48 CFR 31.101 - Objectives.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... Class deviations for the National Aeronautics and Space Administration require advance approval of the..., Technology, and Logistics. [48 FR 42301, Sept. 19, 1983, as amended at 56 FR 67133, Dec. 27, 1991; 61 FR...

Selenium Supplementation Restores Innate and Humoral Immune Responses in Footrot-Affected Sheep

PubMed Central

Hall, Jean A.; Vorachek, William R.; Stewart, Whitney C.; Gorman, M. Elena; Mosher, Wayne D.; Pirelli, Gene J.; Bobe, Gerd

2013-01-01

Dietary selenium (Se) alters whole-blood Se concentrations in sheep, dependent upon Se source and dosage administered, but little is known about effects on immune function. We used footrot (FR) as a disease model to test the effects of supranutritional Se supplementation on immune function. To determine the effect of Se-source (organic Se-yeast, inorganic Na-selenite or Na-selenate) and Se-dosage (1, 3, 5 times FDA-permitted level) on FR severity, 120 ewes with and 120 ewes without FR were drenched weekly for 62 weeks with different Se sources and dosages (30 ewes/treatment group). Innate immunity was evaluated after 62 weeks of supplementation by measuring neutrophil bacterial killing ability. Adaptive immune function was evaluated by immunizing sheep with keyhole limpet hemocyanin (KLH). The antibody titer and delayed-type hypersensitivity skin test to KLH were used to assess humoral immunity and cell-mediated immunity, respectively. At baseline, FR-affected ewes had lower whole-blood and serum-Se concentrations; this difference was not observed after Se supplementation. Se supplementation increased neutrophil bacterial killing percentages in FR-affected sheep to percentages observed in supplemented and non-supplemented healthy sheep. Similarly, Se supplementation increased KLH antibody titers in FR-affected sheep to titers observed in healthy sheep. FR-affected sheep demonstrated suppressed cell-mediated immunity at 24 hours after intradermal KLH challenge, although there was no improvement with Se supplementation. We did not consistently prevent nor improve recovery from FR over the 62 week Se-treatment period. In conclusion, Se supplementation does not prevent FR, but does restore innate and humoral immune functions negatively affected by FR. PMID:24340044

Resistance training attenuates fat mass regain after weight loss in ovariectomized rats.

PubMed

Pighon, Abdolnaser; Paquette, Amélie; Barsalani, Razieh; Chapados, Natalie Ann; Rabasa-Lhoret, Rémi; Yasari, Siham; Prud'homme, Denis; Lavoie, Jean-Marc

2009-09-20

The aim of the present study was to investigate the effects of maintaining only one of the two components of a food restriction (FR)+resistance training (RT) regimen on the regain of body weight and fat mass (liver and adipocytes) in ovariectomized (Ovx) rats. Five week Ovx rats were submitted to a weight loss program consisting of a 26% FR combined with RT (OvxFR+RT) for 8 weeks. RT consisted of climbing a 1.5m vertical grid with a load attached to the tail, 20-40 times with progressively increasing loads 4 times/week. Following this weight loss intervention, OvxFR+RT rats were sub-divided into 3 groups for an additional 5 weeks: 2 groups went back to a normal ad libitum feeding with or without RT and the other group kept only FR. Combined FR+RT program in Ovx rats led to lower body mass gain, liver triacylglycerol (TAG) levels, and fat mass gain compared to sedentary normally fed Ovx rats (P<0.01). Stopping both FR and RT over a 5 week period resulted in the regain of body weight, intra-abdominal fat pad weight and liver TAG (P<0.01). When only FR was maintained, the regain of body and fat pad weight as well as liver and plasma TAG concentrations was completely prevented. However, when only RT was maintained, regain in the aforementioned parameters was attenuated but not prevented (P<0.05). It is concluded that following a FR+RT weight loss program, continuation of only RT constitutes an asset to attenuate body weight and fat mass regain in Ovx rats; although the impact is less than the maintaining FR alone. These results suggest that, in post-menopausal women, RT is a positive strategy to reduce body weight and fat mass relapse.

Impact of food restriction and cocaine on locomotion in ghrelin- and ghrelin-receptor knockout mice.

PubMed

Clifford, Shane; Zeckler, Rosie Albarran; Buckman, Sam; Thompson, Jeff; Hart, Nigel; Wellman, Paul J; Smith, Roy G

2011-07-01

Food restriction (FR) augments the behavioral and reinforcing effects of psychomotor stimulants such as cocaine or amphetamine; effects that may be related to the capacity of FR to increase plasma levels of ghrelin (GHR), a 28-amino acid orexigenenic peptide linked to activation of brain dopamine systems. The present study used wild-type (WT) mice or mutant mice sustaining knockout of either GHR [GHR((-/-)) ] or of the growth hormone secretagogue receptor [GHS-R((-/-)) ] and subjected to FR or not to evaluate the role of GHR and GHS-R in cocaine-stimulated locomotion. WT, GHR((-/-)) , and GHS-R((-/-)) mice were either restricted to 60% of baseline caloric intake or allowed to free-feed (FF). Mice were treated with 0, 1.25, 2.5 and 5.0 mg/kg cocaine on separate test days (in random dose order) and forward locomotion was recorded on each drug day for 45 minutes after drug dosing. Food (and water) was available immediately after (but not during) each activity test. For FF mice, there was no interaction between cocaine and GHR status on locomotion. FR-WT mice treated with saline exhibited significant increases in anticipatory locomotion (relative to FF-WT mice), whereas FR-GHS-R((-/-)) mice did not. Cocaine significantly increased locomotion in FR-GHR((-/-)) and FR-GHS-R((-/-)) mice to the levels noted in FR-WT mice. These results suggest that GHS-R activity, but not GHR activity, is required for FR to augment food-associated anticipatory locomotion, but do not support the contention that GHR pathways are required for the capacity of FR to augment the acute effect of cocaine on locomotion. © 2010 The Authors, Addiction Biology © 2010 Society for the Study of Addiction.

Higher whole-blood selenium is associated with improved immune responses in footrot-affected sheep.

PubMed

Hall, Jean A; Sendek, Rachel L; Chinn, Rachel M; Bailey, D Paul; Thonstad, Katie N; Wang, Yongqiang; Forsberg, Neil E; Vorachek, William R; Stang, Bernadette V; Van Saun, Robert J; Bobe, Gerd

2011-09-06

We reported previously that sheep affected with footrot (FR) have lower whole-blood selenium (WB-Se) concentrations and that parenteral Se-supplementation in conjunction with routine control practices accelerates recovery from FR. The purpose of this follow-up study was to investigate the mechanisms by which Se facilitates recovery from FR. Sheep affected with FR (n = 38) were injected monthly for 15 months with either 5 mg Se (FR-Se) or saline (FR-Sal), whereas 19 healthy sheep received no treatment. Adaptive immune function was evaluated after 3 months of Se supplementation by immunizing all sheep with a novel protein, keyhole limpet hemocyanin (KLH). The antibody titer and delayed-type hypersensitivity (DTH) skin test to KLH were used to assess humoral immunity and cell-mediated immunity, respectively. Innate immunity was evaluated after 3 months of Se supplementation by measuring intradermal responses to histamine 30 min after injection compared to KLH and saline, and after 15 months of Se supplementation by isolating neutrophils and measuring their bacterial killing ability and relative abundance of mRNA for genes associated with neutrophil migration. Compared to healthy sheep, immune responses to a novel protein were suppressed in FR-affected sheep with smaller decreases in FR-affected sheep that received Se or had WB-Se concentrations above 250 ng/mL at the time of the immune assays. Neutrophil function was suppressed in FR-affected sheep, but was not changed by Se supplementation or WB-Se status. Sheep FR is associated with depressed immune responses to a novel protein, which may be partly restored by improving WB-Se status (> 250 ng/mL).

Higher whole-blood selenium is associated with improved immune responses in footrot-affected sheep

PubMed Central

2011-01-01

We reported previously that sheep affected with footrot (FR) have lower whole-blood selenium (WB-Se) concentrations and that parenteral Se-supplementation in conjunction with routine control practices accelerates recovery from FR. The purpose of this follow-up study was to investigate the mechanisms by which Se facilitates recovery from FR. Sheep affected with FR (n = 38) were injected monthly for 15 months with either 5 mg Se (FR-Se) or saline (FR-Sal), whereas 19 healthy sheep received no treatment. Adaptive immune function was evaluated after 3 months of Se supplementation by immunizing all sheep with a novel protein, keyhole limpet hemocyanin (KLH). The antibody titer and delayed-type hypersensitivity (DTH) skin test to KLH were used to assess humoral immunity and cell-mediated immunity, respectively. Innate immunity was evaluated after 3 months of Se supplementation by measuring intradermal responses to histamine 30 min after injection compared to KLH and saline, and after 15 months of Se supplementation by isolating neutrophils and measuring their bacterial killing ability and relative abundance of mRNA for genes associated with neutrophil migration. Compared to healthy sheep, immune responses to a novel protein were suppressed in FR-affected sheep with smaller decreases in FR-affected sheep that received Se or had WB-Se concentrations above 250 ng/mL at the time of the immune assays. Neutrophil function was suppressed in FR-affected sheep, but was not changed by Se supplementation or WB-Se status. Sheep FR is associated with depressed immune responses to a novel protein, which may be partly restored by improving WB-Se status (> 250 ng/mL). PMID:21896161

Feasible and technical aspects of transcatheter arterial chemoembolization for non-resectable hepatocellular carcinoma using a 3.5-French catheter system.

PubMed

Yagyu, Yukinobu; Tsurusaki, Masakatsu; Kamiyama, Kazutoshi; Kitagaki, Hajime; Murakami, Takamichi

2014-12-01

To evaluate the feasibility and technical aspects of transcatheter arterial chemoembolization (TACE) for non-resectable hepatocellular carcinoma (HCC) using a 3.5-French (Fr) catheter system. This study included 328 consecutive cases of HCC among 232 patients who underwent TACE procedures using both a 3.5-Fr catheter system and a microcatheter fitted to a 3.5-Fr system between April 2009 and November 2011. We assessed the ability to reach the catheter into the proper hepatic artery (PHA), main hepatic branch, segmental artery, and subsegmental or sub-subsegmental artery. The feasibility was rated according to the following factors: (1) the number of arteries that could be used to reach the target artery/total number of procedures using the 3.5-Fr system, (2) the rate of successful completion of the procedures without changing over to the 4-Fr system and (3) the reasons for changing over the 4-Fr system. TACE of the PHA (27 sessions), RHA/LHA (103 sessions), segmental (31 sessions), or subsegmental/sub-subsegmental arteries (162 sessions) was performed. The rate of successfully reaching the target artery using the 3.5-Fr system was 93% (306/328 sessions). We were unable to reach the target artery in 22 sessions, including 11/8/3 procedures targeting the sub-subsegmental artery, subsegmental artery, and RHA/LHA, respectively. We changed over to the 4-Fr system in six sessions; therefore, the rate of successful completion of the procedures without changing over to the 4-Fr system was 98% (322/328 sessions). TACE of the target artery can be successfully performed using the 3.5-Fr system in most patients with HCC.

7 CFR 319.41 - Notice of quarantine.

Code of Federal Regulations, 2014 CFR

2014-01-01

...), grain sorghums (Andropogon sorghum), Sudan grass (Andropogon sorghum sudanensis), Johnson grass... Islands of the United States. [24 FR 10788, Dec. 29, 1959, as amended at 66 FR 21056, Apr. 27, 2001; 78 FR...

75 FR 41233 - Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-15

... Mexico, Museum of 30, 2009. Southwestern Biology. 08939A Los Angeles Zoo........ 75 FR 23279; May 3, June.... California at Berkeley. 228022 Metro Richmond Zoo..... 75 FR 427; January 5, April 12, 2010 2010. 231585...

Neurocognition and symptoms identify links between facial recognition and emotion processing in schizophrenia: Meta-analytic findings

PubMed Central

Ventura, Joseph; Wood, Rachel C.; Jimenez, Amy M.; Hellemann, Gerhard S.

2014-01-01

Background In schizophrenia patients, one of the most commonly studied deficits of social cognition is emotion processing (EP), which has documented links to facial recognition (FR). But, how are deficits in facial recognition linked to emotion processing deficits? Can neurocognitive and symptom correlates of FR and EP help differentiate the unique contribution of FR to the domain of social cognition? Methods A meta-analysis of 102 studies (combined n = 4826) in schizophrenia patients was conducted to determine the magnitude and pattern of relationships between facial recognition, emotion processing, neurocognition, and type of symptom. Results Meta-analytic results indicated that facial recognition and emotion processing are strongly interrelated (r = .51). In addition, the relationship between FR and EP through voice prosody (r = .58) is as strong as the relationship between FR and EP based on facial stimuli (r = .53). Further, the relationship between emotion recognition, neurocognition, and symptoms is independent of the emotion processing modality – facial stimuli and voice prosody. Discussion The association between FR and EP that occurs through voice prosody suggests that FR is a fundamental cognitive process. The observed links between FR and EP might be due to bottom-up associations between neurocognition and EP, and not simply because most emotion recognition tasks use visual facial stimuli. In addition, links with symptoms, especially negative symptoms and disorganization, suggest possible symptom mechanisms that contribute to FR and EP deficits. PMID:24268469

Neurocognition and symptoms identify links between facial recognition and emotion processing in schizophrenia: meta-analytic findings.

PubMed

Ventura, Joseph; Wood, Rachel C; Jimenez, Amy M; Hellemann, Gerhard S

2013-12-01

In schizophrenia patients, one of the most commonly studied deficits of social cognition is emotion processing (EP), which has documented links to facial recognition (FR). But, how are deficits in facial recognition linked to emotion processing deficits? Can neurocognitive and symptom correlates of FR and EP help differentiate the unique contribution of FR to the domain of social cognition? A meta-analysis of 102 studies (combined n=4826) in schizophrenia patients was conducted to determine the magnitude and pattern of relationships between facial recognition, emotion processing, neurocognition, and type of symptom. Meta-analytic results indicated that facial recognition and emotion processing are strongly interrelated (r=.51). In addition, the relationship between FR and EP through voice prosody (r=.58) is as strong as the relationship between FR and EP based on facial stimuli (r=.53). Further, the relationship between emotion recognition, neurocognition, and symptoms is independent of the emotion processing modality - facial stimuli and voice prosody. The association between FR and EP that occurs through voice prosody suggests that FR is a fundamental cognitive process. The observed links between FR and EP might be due to bottom-up associations between neurocognition and EP, and not simply because most emotion recognition tasks use visual facial stimuli. In addition, links with symptoms, especially negative symptoms and disorganization, suggest possible symptom mechanisms that contribute to FR and EP deficits. © 2013 Elsevier B.V. All rights reserved.

Reduction of FR900525 using an S-(2-aminoethyl) l-cysteine-resistant mutant.

PubMed

Shimizu, Shiho; Futase, Ayako; Yokoyama, Tatsuya; Ueda, Satoshi; Honda, Hiroyuki

2017-06-01

FK506 (tacrolimus), a macrolide compound with immunosuppressant activity, has been proven to have clinical importance and has been manufactured industrially since 1993 by using mutants with high FK506-production ability; these mutants have been developed from the wild strain Streptomyces tsukubaensis No. 9993. FR900525 is one of the by-products of FK506 production. However, there was no effective industrial method to separate FR900525 from FK506 due to the structural similarity between the two compounds. Therefore, reducing the level of FR900525 was a serious problem in the industrial strain A. In this study, we aimed to reduce the FR900525 production. We first determined that pipecolic acid level was a critical parameter for controlling FR900525 production in strain A. S-(2-Aminoethyl) l-cysteine (AEC)-resistant mutants has been reported to increase lysine productivity successfully in a variety of lysine-producing microorganisms. Therefore, next, we applied a selection of AEC-resistant mutants to enhance pipecolic acid biosynthesis. Finally, four AEC-resistant mutants were obtained from strain A using ultraviolet irradiation, and three of them showed less FR900525 productivity compared to the parental strain A. Our findings indicated that AEC resistance was effective phenotype marker for increasing pipecolic acid productivity and for reducing FR900525 production in S. tsukubaensis. Thus, our study provides an efficient method for reducing FR90025 level during FK506 biosynthesis. Copyright © 2017 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

75 FR 14438 - PPL Montana, LLC; Notice of Petition for Declaratory Order

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-25

..., 68 FR 49,846 (Aug. 19, 2003), FERC Stats. & Regs ] 31,146 (2003) (Order No. 2003); order on reh'g, Order No. 2003-A, 69 FR 15,932 (Mar. 26, 2004), FERC Stats. & Regs. 31,160, at P 531 (2004) (Order No. 2003-A); order on reh'g, Order No. 2003-B, 70 FR 265 (Jan. 4, 2005) (Order No. 2003-B) FERC Stats...

26 CFR 31.6011(a)-4 - Returns of income tax withheld.

Code of Federal Regulations, 2010 CFR

2010-04-01

...) Retirement pay for services in the Armed Forces of the United States subject to withholding under section..., 26 U.S.C. 7805; 68A Stat. 747, 26 U.S.C. 6051) [T.D. 6516, 25 FR 13032, Dec. 20, 1960, as amended by T.D. 7096, 36 FR 5217, Mar. 18, 1971; T.D. 7200, 37 FR 16544, Aug. 16, 1972; T.D. 7577, 43 FR 59359...

26 CFR 31.6011(a)-4 - Returns of income tax withheld.

Code of Federal Regulations, 2011 CFR

2011-04-01

...) Retirement pay for services in the Armed Forces of the United States subject to withholding under section..., 26 U.S.C. 7805; 68A Stat. 747, 26 U.S.C. 6051) [T.D. 6516, 25 FR 13032, Dec. 20, 1960, as amended by T.D. 7096, 36 FR 5217, Mar. 18, 1971; T.D. 7200, 37 FR 16544, Aug. 16, 1972; T.D. 7577, 43 FR 59359...

77 FR 62150 - Approval and Promulgation of Implementation Plans; Kentucky; Approval of Revisions to the...

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2012-10-12

... Existing Indirect Heat Exchangers. 6.08 Standard of 10/23/01 66 FR 53660 06/13/79 Performance for Existing.../21/82 Performance for New Indirect Heat Exchangers. 7.07 Standard of 10/23/01 66 FR 53661 09/15/93... 10/23/01 66 FR 53662 03/17/93 Performance for New Insulation of Magnet Wire. 7.56 Standard of 10/23...

33 CFR 401.74 - Transit declaration.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... Lambert, Quebec, J4R 2V6 or from the St. Lawrence Seaway Web site at http://www.greatlakes-seaway.com. (b..., as amended and secs. 4, 5, 6, 7, 8, 12 and 13 of sec. 2 of Pub. L. 95-474, 92 Stat. 1471) [39 FR 10900, Mar. 22, 1974, as amended at 48 FR 20691, May 9, 1983; 49 FR 30936, Aug. 2, 1984; 65 FR 52914...

75 FR 58305 - Approval and Promulgation of Air Quality Implementation Plans; Indiana; Revised Format for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-24

... and Electric Company. Article 6.5. Particulate Matter Limitations Except Lake County 6.5-1 General... County 2/22/2008 4/30/2008, 73 FR 23356. Article 6.8. Particulate Matter Limitations for Lake County 6.8..., 73 FR 23356. Sec. 1, 5, 7. 6.8-2 Lake County: PM10 2/22/2008 4/30/2008, 73 FR 23356. Emission...

40 CFR 52.570 - Identification of plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

.../99, 64 FR 67491 391-3-1-.02(2)(d) Fuel-burning Equipment 7/20/05 2/9/09, 75 FR 6309 391-3-1-.02(2)(e.../18/79, 44 FR 54047 391-3-1-.02(2)(k) Particulate Emission from Asphaltic Concrete Hot Mix Plants 1/17...) NOX Emissions from Fuel-burning Equipment 2/16/00 7/10/01, 66 FR 35906 391-3-1-.02(2)(mmm) NOX...

77 FR 24459 - Reorganization of Foreign-Trade Zone 226 Under Alternative Site Framework Merced County, CA

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2012-04-24

... FR 1170, 01/12/2009; correction 74 FR 3987, 01/22/2009; 75 FR 71069- 71070, 11/22/2010) as an option... magnet sites, existing Site 8 would be categorized as a usage-driven site, Sites 3, 4, 6, 7, 12 and 13... 30, 2017, and to a three-year sunset provision for usage-driven sites that would terminate authority...

Trichomonas vaginalis Flavin Reductase 1 and its Role in Metronidazole Resistance

PubMed Central

Leitsch, David; Janssen, Brian D.; Kolarich, Daniel; Johnson, Patricia J.; Duchêne, Michael

2015-01-01

Summary The enzyme flavin reductase 1 (FR1) from Trichomonas vaginalis, formerly known as NADPH oxidase, was isolated and identified. Flavin reductase is part of the antioxidative defense in T. vaginalis and indirectly reduces molecular oxygen to hydrogen peroxide via free flavins. Importantly, a reduced or absent flavin reductase activity has been reported in metronidazole-resistant T. vaginalis, resulting in elevated intracellular oxygen levels and futile cycling of metronidazole. Interestingly, FR1 has no close homologue in any other sequenced genome, but seven full-length and three truncated isoforms exist in the T. vaginalis genome. However, out of these, only FR1 has an affinity for flavins, i.e. FMN, FAD, and riboflavin, which is high enough to be of physiological relevance. Although there are no relevant changes in the gene sequence or any alterations of the predicted FR1-mRNA structure in any of the strains studied, FR1 is not expressed in highly metronidazole-resistant strains. Transfection of a metronidazole-resistant clinical isolate (B7268), which does not express any detectable amounts of FR, with a plasmid bearing a functional FR1 gene nearly completely restored metronidazole sensitivity. Our results indicate that FR1 has a significant role in the emergence of metronidazole resistance in T. vaginalis. PMID:24256032

Diet Modifies Colonic Microbiota and CD4+ T Cell Repertoire to Induce Flares of Colitis in Mice With Myeloid-cell Expression of Interleukin 23.

PubMed

Chen, Lili; He, Zhengxiang; Iuga, Alina Cornelia; Martins Filho, Sebastião N; Faith, Jeremiah J; Clemente, Jose C; Deshpande, Madhura; Jayaprakash, Anitha; Colombel, Jean-Frederic; Lafaille, Juan J; Sachidanandam, Ravi; Furtado, Glaucia C; Lira, Sergio A

2018-06-14

Several studies have shown that signaling via the interleukin 23 (IL23) receptor is required for development of colitis. We studied the roles of IL23, dietary factors, alterations to the microbiota, and T cells in development and progression of colitis in mice. All mice were maintained on lab diet 5053, unless otherwise noted. We generated mice that express IL23 in CX3CR1-positive myeloid cells (R23FR mice) upon cyclic administration of tamoxifen dissolved in diet 2019. Diet 2019 and 5053 have minor differences in the overall composition of protein, fat, fiber, minerals, and vitamins. CX3CR1 CreER mice (FR mice) were used as controls. Some mice were given antibiotics and others were raised in a germ-free environment. Intestinal tissues were collected and analyzed by histology and flow cytometry. Feces were collected and analyzed by 16S rDNA sequencing. Feces from C57/Bl6, R23FR, or FR mice were fed to FR and R23FR germ-free mice in microbiota transplant experiments. We also performed studies with R23FR/Rag -/- , R23FR/Mu -/- , and R23FR/Tcrd -/- mice. R23FR mice were given injections of antibodies against CD4 or CD8 to deplete T cells. Mesenteric lymph nodes and large intestine CD4 + cells from R23FR or FR mice in remission from colitis were transferred into Rag -/- mice. CD4 + cells were isolated from donor R23FR mice and recipient Rag -/- mice, and T-cell receptor sequences were determined. Expression of IL23 led to development of a relapsing-remitting colitis that was dependent on the microbiota and CD4 + T cells. The relapses were caused by switching from the conventional diet used in our facility (diet 5053) to the diet 2019, and were not dependent on tamoxifen after the first cycle. The switch in the diet modified the microbiota, but did not alter levels of IL23 in intestinal tissues, compared to mice that remained on the conventional diet. Mesenteric lymph nodes and large intestine CD4 + cells from R23FR mice in remission, but not from FR mice, induced colitis after transfer into Rag -/- mice, but only when these mice were placed on the diet 2019. The CD4 + T-cell receptor repertoire of Rag -/- mice with colitis (fed the 2019 diet) was less diverse than that from donor mice and Rag -/- mice without colitis (fed the 5053 diet), due to expansion of dominant T-cell clones. We developed mice that express IL23 in CX3CR1-positive myeloid cells (R23FR mice) and found they are more susceptible to diet-induced colitis than mice that do not express IL23. The R23FR mice have a population of CD4 + T cells that becomes activated in response to dietary changes and alterations to the intestinal microbiota. The results indicate that alterations in the diet, intestinal microbiota, and IL23 signaling can contribute to pathogenesis of inflammatory bowel disease. Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.

40 CFR 271.1 - Purpose and scope.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Methyl Bromide 54 FR 41402-408 Apr. 6, 1990. Dec. 11, 1989 Listing Certain Hydrocarbons Produced by Free Radical Catalyzed Processes 54 FR 50968-978 June 11, 1990. Mar. 29, 1990 Toxicity characteristic 55 FR...

40 CFR 271.1 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Methyl Bromide 54 FR 41402-408 Apr. 6, 1990. Dec. 11, 1989 Listing Certain Hydrocarbons Produced by Free Radical Catalyzed Processes 54 FR 50968-978 June 11, 1990. Mar. 29, 1990 Toxicity characteristic 55 FR...

49 CFR 390.17 - Additional equipment and accessories.

Code of Federal Regulations, 2010 CFR

2010-10-01

... equipment and accessories, not inconsistent with or prohibited by this subchapter, provided such equipment... are used. [53 FR 18052, May 19, 1988, as amended at 60 FR 38744, July 28, 1995. Redesignated at 65 FR...

75 FR 2560 - Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-15

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75 FR 6151 - Chartering and Field of Membership for Federal Credit Unions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-08

... the terms ``rural district'' and ``in danger of insolvency'' for emergency merger purposes. 74 FR... the term ``in danger of insolvency'' for emergency merger purposes. 74 FR 68722 (December 29, 2009...

47 CFR 74.784 - Rebroadcasts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... the station whose signals or programs are proposed to be retransmitted. The FCC, Attention: Video.... 325) [28 FR 13722, Dec. 14, 1963, as amended at 47 FR 21502, May 18, 1982; 52 FR 31405, Aug. 20, 1987...

47 CFR 74.784 - Rebroadcasts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... the station whose signals or programs are proposed to be retransmitted. The FCC, Attention: Video.... 325) [28 FR 13722, Dec. 14, 1963, as amended at 47 FR 21502, May 18, 1982; 52 FR 31405, Aug. 20, 1987...

47 CFR 74.784 - Rebroadcasts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... the station whose signals or programs are proposed to be retransmitted. The FCC, Attention: Video.... 325) [28 FR 13722, Dec. 14, 1963, as amended at 47 FR 21502, May 18, 1982; 52 FR 31405, Aug. 20, 1987...

47 CFR 51.5 - Terms and definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... voice, data, graphics or video telecommunications using any technology. Arbitration, final offer. Final... 1344, Jan. 10, 2000; 65 FR 2550, Jan. 18, 2000; 65 FR 54438, Sept. 8, 2000; 66 FR 43521, Aug. 20, 2001...

47 CFR 74.784 - Rebroadcasts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... the station whose signals or programs are proposed to be retransmitted. The FCC, Attention: Video.... 325) [28 FR 13722, Dec. 14, 1963, as amended at 47 FR 21502, May 18, 1982; 52 FR 31405, Aug. 20, 1987...

47 CFR 74.784 - Rebroadcasts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... the station whose signals or programs are proposed to be retransmitted. The FCC, Attention: Video.... 325) [28 FR 13722, Dec. 14, 1963, as amended at 47 FR 21502, May 18, 1982; 52 FR 31405, Aug. 20, 1987...

38 CFR 17.40 - Additional services for indigents.

Code of Federal Regulations, 2010 CFR

2010-07-01

... services, including haircutting and shaving necessary for hygienic reasons. [33 FR 5299, Apr. 3, 1968, as amended at 47 FR 58247, Dec. 30, 1982. Redesignated at 61 FR 21965, May 13, 1996] Examinations and...

Response requirement and increases in accuracy produced by stimulant drugs in a 5-choice serial reaction-time task in rats.

PubMed

Koffarnus, Mikhail N; Katz, Jonathan L

2011-02-01

Increased signal-detection accuracy on the 5-choice serial reaction time (5-CSRT) task has been shown with drugs that are useful clinically in treating attention deficit hyperactivity disorder (ADHD), but these increases are often small and/or unreliable. By reducing the reinforcer frequency, it may be possible to increase the sensitivity of this task to pharmacologically induced improvements in accuracy. Rats were trained to respond on the 5-CSRT task on a fixed ratio (FR) 1, FR 3, or FR 10 schedule of reinforcement. Drugs that were and were not expected to enhance performance were then administered before experimental sessions. Significant increases in accuracy of signal detection were not typically obtained under the FR 1 schedule with any drug. However, d-amphetamine, methylphenidate, and nicotine typically increased accuracy under the FR 3 and FR 10 schedules. Increasing the FR requirement in the 5-CSRT task increases the likelihood of a positive result with clinically effective drugs, and may more closely resemble conditions in children with attention deficits.

Radiation-grafting of flame retardants on flax fabrics - A comparison between different flame retardant structures

NASA Astrophysics Data System (ADS)

Teixeira, Marie; Sonnier, Rodolphe; Otazaghine, Belkacem; Ferry, Laurent; Aubert, Mélanie; Tirri, Teija; Wilén, Carl-Eric; Rouif, Sophie

2018-04-01

Three unsaturated compounds bearing respectively phosphate, aryl bromide and sulfenamide moieties were used as flame retardants (FR) for flax fabrics. Due to the presence of carbon-carbon double bonds, radiation-grafting was considered to covalently bond these FR onto fiber structure. Grafting efficiency and location of FR molecules were investigated by weight measurements and SEM-EDX observations. Flammability and especially self-extinguishment were assessed by thermogravimetric analysis, pyrolysis-combustion flow calorimetry and a non-standardized fire test already used in previous studies. All FRs were able to diffuse into elementary fiber bulk. Nevertheless only the phosphonated monomer (noted FR-P) was significantly grafted onto flax. Self-extinguishment was obtained for fabrics containing at least around 0.5 wt% of phosphorus. On the contrary the FR content of flax fibers after radiation-grafting procedure and washing was negligible for FR-S and FR-Br, evidencing that these molecules have not been grafted upon irradiation. Moreover, the combination of these molecules prevents the radiation-grafting of other molecules which showed good grafting rate when used alone.

An optimized fluorescent probe for visualizing glutamate neurotransmission.

PubMed

Marvin, Jonathan S; Borghuis, Bart G; Tian, Lin; Cichon, Joseph; Harnett, Mark T; Akerboom, Jasper; Gordus, Andrew; Renninger, Sabine L; Chen, Tsai-Wen; Bargmann, Cornelia I; Orger, Michael B; Schreiter, Eric R; Demb, Jonathan B; Gan, Wen-Biao; Hires, S Andrew; Looger, Loren L

2013-02-01

We describe an intensity-based glutamate-sensing fluorescent reporter (iGluSnFR) with signal-to-noise ratio and kinetics appropriate for in vivo imaging. We engineered iGluSnFR in vitro to maximize its fluorescence change, and we validated its utility for visualizing glutamate release by neurons and astrocytes in increasingly intact neurological systems. In hippocampal culture, iGluSnFR detected single field stimulus-evoked glutamate release events. In pyramidal neurons in acute brain slices, glutamate uncaging at single spines showed that iGluSnFR responds robustly and specifically to glutamate in situ, and responses correlate with voltage changes. In mouse retina, iGluSnFR-expressing neurons showed intact light-evoked excitatory currents, and the sensor revealed tonic glutamate signaling in response to light stimuli. In worms, glutamate signals preceded and predicted postsynaptic calcium transients. In zebrafish, iGluSnFR revealed spatial organization of direction-selective synaptic activity in the optic tectum. Finally, in mouse forelimb motor cortex, iGluSnFR expression in layer V pyramidal neurons revealed task-dependent single-spine activity during running.

76 FR 1409 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-10

... 17) can be deleted. The records covered by this system are also covered by Defense Finance and Accounting Service records notice T7332, Defense Debt Management System (February 19, 2009, 74 FR 7665). [FR...

49 CFR 385.1 - Purpose and scope.

Code of Federal Regulations, 2013 CFR

2013-10-01

... operating a CMV. (b) This part establishes the safety assurance program for a new entrant motor carrier... Regulations (FMCSRs). [65 FR 50934, Aug. 22, 2000, as amended at 67 FR 31982, May 13, 2002; 69 FR 39366, June...

49 CFR 385.1 - Purpose and scope.

Code of Federal Regulations, 2014 CFR

2014-10-01

... operating a CMV. (b) This part establishes the safety assurance program for a new entrant motor carrier... Regulations (FMCSRs). [65 FR 50934, Aug. 22, 2000, as amended at 67 FR 31982, May 13, 2002; 69 FR 39366, June...

49 CFR 385.1 - Purpose and scope.

Code of Federal Regulations, 2012 CFR

2012-10-01

... operating a CMV. (b) This part establishes the safety assurance program for a new entrant motor carrier... Regulations (FMCSRs). [65 FR 50934, Aug. 22, 2000, as amended at 67 FR 31982, May 13, 2002; 69 FR 39366, June...

24 CFR 941.101 - Purpose and scope.

Code of Federal Regulations, 2011 CFR

2011-04-01

... housing residents over the long term and have the lowest possible life cycle costs, taking into account.... [61 FR 38016, July 22, 1996, as amended at 64 FR 13511, Mar. 19, 1999] Effective Date Note: At 61 FR...

24 CFR 941.101 - Purpose and scope.

Code of Federal Regulations, 2012 CFR

2012-04-01

... housing residents over the long term and have the lowest possible life cycle costs, taking into account.... [61 FR 38016, July 22, 1996, as amended at 64 FR 13511, Mar. 19, 1999] Effective Date Note: At 61 FR...

24 CFR 941.101 - Purpose and scope.

Code of Federal Regulations, 2013 CFR

2013-04-01

... housing residents over the long term and have the lowest possible life cycle costs, taking into account.... [61 FR 38016, July 22, 1996, as amended at 64 FR 13511, Mar. 19, 1999] Effective Date Note: At 61 FR...

78 FR 73884 - Notice Pursuant to the National Cooperative Research and Production Act of 1993; National...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-09

..., Blackhawk Management, Houston, TX; Blue Juice, Inc., San Rafael, CA; Engineering and Management Executives... FR 52787). Patricia A. Brink, Director of Civil Enforcement, Antitrust Division. [FR Doc. 2013-29272...

48 CFR 22.1304 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-100A Report, the contracting officer may— (a) Query the Department of Labor's VETS-100 Database via the... the database. [66 FR 53488, Oct. 22, 2001, as amended at 71 FR 67779, Nov. 22, 2006; 75 FR 60251, Sept...

48 CFR 22.1304 - Procedures.

Code of Federal Regulations, 2011 CFR

2011-10-01

...-100A Report, the contracting officer may— (a) Query the Department of Labor's VETS-100 Database via the... the database. [66 FR 53488, Oct. 22, 2001, as amended at 71 FR 67779, Nov. 22, 2006; 75 FR 60251, Sept...

33 CFR 403.6 - Additional information. [Rule 6

Code of Federal Regulations, 2010 CFR

2010-07-01

..., DEPARTMENT OF TRANSPORTATION RULES OF PROCEDURE OF THE JOINT TOLLS REVIEW BOARD § 403.6 Additional.... [Rule 6] [24 FR 9307, Nov. 18, 1959; 24 FR 10445, Dec. 23, 1959. Redesignated at 47 FR 13805, Apr. 1...

76 FR 27660 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-12

...; March 9, April 21, 2011. Society dba 2011. Brookfield Zoo. 24269A Chelonian Research 75 FR 62139.... Survey, Alaska 10, 2011. Science Center. 19806A Thomas Postel......... 75 FR 78731; December May 6, 2011...

7 CFR 301.45-3 - Generally infested areas.

Code of Federal Regulations, 2012 CFR

2012-01-01

... county. Brooke County. The entire county. Calhoun County. The entire county. Doddridge County. The entire..., Apr. 28, 2006; 71 FR 53547, Sept. 12, 2006; 71 FR 66830, Nov. 17, 2006; 74 FR 48002, Sept. 21, 2009...

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2011-11-23

... Form 2290/SP/FR Heavy Highway Vehicle Use Tax Return. DATES: Written comments should be received on or... . SUPPLEMENTARY INFORMATION: Title: Heavy Highway Vehicle Use Tax Return. OMB Number: 1545-0143. Abstract: Form...

47 CFR 64.611 - Internet-based TRS registration.

Code of Federal Regulations, 2013 CFR

2013-10-01

... obligations under paragraphs (a), (c), (d), and (e) of this section using the Neutral Video Communication Service Platform. [73 FR 41295, July 18, 2008, as amended at 76 FR 59557, Sept. 27, 2011; 78 FR 40608...

48 CFR 225.1103 - Other provisions and clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

...-7007, Prohibition on Acquisition of United States Munitions List Items from Communist Chinese Military... Munitions List. [68 FR 16526, Mar. 31, 2003, as amended at 71 FR 39006, July 11, 2006; 71 FR 53046, Sept. 8...

48 CFR 225.1103 - Other provisions and clauses.

Code of Federal Regulations, 2012 CFR

2012-10-01

...-7007, Prohibition on Acquisition of United States Munitions List Items from Communist Chinese Military... Munitions List. [68 FR 16526, Mar. 31, 2003, as amended at 71 FR 39006, July 11, 2006; 71 FR 53046, Sept. 8...

A viable logarithmic f(R) model for inflation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Amin, M.; Khalil, S.; Salah, M.

2016-08-18

Inflation in the framework of f(R) modified gravity is revisited. We study the conditions that f(R) should satisfy in order to lead to a viable inflationary model in the original form and in the Einstein frame. Based on these criteria we propose a new logarithmic model as a potential candidate for f(R) theories aiming to describe inflation consistent with observations from Planck satellite (2015). The model predicts scalar spectral index 0.9615

16 CFR 801.15 - Aggregation of voting securities and assets the acquisition of which was exempt.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) Sections 7A(c) (1), (5), (6), (7), (8), and (11)(B); (2) Sections 802.1, 802.2, 802.5, 802.6(b)(1), 802.8... that the acquisition price was in excess of $50 million (as adjusted). In the most recent year, sales... amended at 52 FR 7081, Mar. 6, 1987; 61 FR 13684, Mar. 28, 1996; 66 FR 8689, Feb. 1, 2001; 67 FR 11902...

40 CFR 52.2420 - Identification of plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Reference conditions 6/24/09 4/25/11, 76 FR 22814 Revised section. 5-30-30 Sulfur Oxides (Sulfur Dioxide) 5... D. 5-30-40 Carbon Monoxide 9/8/04 3/3/06, 71 FR 10842 5-30-50 Ozone (1-hour) 9/8/04 3/3/06, 71 FR... Particulate Matter (AQCR 7) 4/17/95 4/21/00, 65 FR 21315 120-04-0404. 5-40-280 Standard for Sulfur Dioxide 4...

40 CFR 52.2420 - Identification of plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Reference conditions 6/24/09 4/25/11, 76 FR 22814 Revised section. 5-30-30 Sulfur Oxides (Sulfur Dioxide) 5... D. 5-30-40 Carbon Monoxide 9/8/04 3/3/06, 71 FR 10842 5-30-50 Ozone (1-hour) 9/8/04 3/3/06, 71 FR... Particulate Matter (AQCR 7) 4/17/95 4/21/00, 65 FR 21315 120-04-0404. 5-40-280 Standard for Sulfur Dioxide 4...

Episodic sucrose intake during food restriction increases synaptic abundance of AMPA receptors in nucleus accumbens and augments intake of sucrose following restoration of ad libitum feeding.

PubMed

Peng, X-X; Lister, A; Rabinowitsch, A; Kolaric, R; Cabeza de Vaca, S; Ziff, E B; Carr, K D

2015-06-04

Weight-loss dieting often leads to loss of control, rebound weight gain, and is a risk factor for binge pathology. Based on findings that food restriction (FR) upregulates sucrose-induced trafficking of glutamatergic AMPA receptors to the nucleus accumbens (NAc) postsynaptic density (PSD), this study was an initial test of the hypothesis that episodic "breakthrough" intake of forbidden food during dieting interacts with upregulated mechanisms of synaptic plasticity to increase reward-driven feeding. Ad libitum (AL) fed and FR subjects consumed a limited amount of 10% sucrose, or had access to water, every other day for 10 occasions. Beginning three weeks after return of FR rats to AL feeding, when 24-h chow intake and rate of body weight gain had normalized, subjects with a history of sucrose intake during FR consumed more sucrose during a four week intermittent access protocol than the two AL groups and the group that had access to water during FR. In an experiment that substituted noncontingent administration of d-amphetamine for sucrose, FR subjects displayed an enhanced locomotor response during active FR but a blunted response, relative to AL subjects, during recovery from FR. This result suggests that the enduring increase in sucrose consumption is unlikely to be explained by residual enhancing effects of FR on dopamine signaling. In a biochemical experiment which paralleled the sucrose behavioral experiment, rats with a history of sucrose intake during FR displayed increased abundance of pSer845-GluA1, GluA2, and GluA3 in the NAc PSD relative to rats with a history of FR without sucrose access and rats that had been AL throughout, whether they had a history of episodic sucrose intake or not. A history of FR, with or without a history of sucrose intake, was associated with increased abundance of GluA1. A terminal 15-min bout of sucrose intake produced a further increase in pSer845-GluA1 and GluA2 in subjects with a history of sucrose intake during FR. Generally, neither a history of sucrose intake nor a terminal bout of sucrose intake affected AMPA receptor abundance in the NAc PSD of AL subjects. Together, these results are consistent with the hypothesis, but the functional contribution of increased synaptic incorporation of AMPA receptors remains to be established. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

Removing interictal fast ripples on electrocorticography linked with seizure freedom in children.

PubMed

Wu, J Y; Sankar, R; Lerner, J T; Matsumoto, J H; Vinters, H V; Mathern, G W

2010-11-09

Fast ripples (FR, 250-500 Hz) detected with chronic intracranial electrodes are proposed biomarkers of epileptogenesis. This study determined whether resection of FR-containing neocortex recorded during intraoperative electrocorticography (ECoG) was associated with postoperative seizure freedom in pediatric patients with mostly extratemporal lesions. FRs were retrospectively reviewed in 30 consecutive pediatric cases. ECoGs were recorded at 2,000 Hz sampling rate and visually inspected for FR, with reviewer blinded to the resection and outcome. Average age at surgery was 9.1 ± 6.7 years, ECoG duration was 11.8 ± 8.1 minutes, and postoperative follow-up was 27 ± 4 months. FRs were undetected in 6 ECoGs with remote or extensive lesions. FR episodes (n = 273) were identified in ECoGs from 24 patients, and in 64% FRs were independent of spikes, sharp waves, voltage attenuation, and paroxysmal fast activity. Of these 24 children, FR-containing cortex was removed in 19 and all became seizure-free, including 1 child after a second surgery. The remaining 5 children had incomplete FR resection and all continued with seizures postoperatively. In 2 ECoGs, the location of electrographic seizures matched FR location. FR-containing cortex was found outside of MRI and FDG-PET abnormalities in 6 children. FRs were detected during intraoperative ECoG in 80% of pediatric epilepsy cases, and complete resection of FR cortex correlated with postoperative seizure freedom. These findings support the view that interictal FRs are excellent surrogate markers of epileptogenesis, can be recorded during brief ECoG, and could be used to guide future surgical resections in children.

Behavioral economic analysis of water intake in a laboratory rhesus macaque.

PubMed

Wakita, Masumi

2004-10-01

Behavioral economics is useful for understanding the influence of environmental manipulation on a variety of behaviors, including drug self-administration, food intake, and stock behavior. The present study employed behavioral economics to investigate the psychologically satisfying amount of water intake in a laboratory rhesus macaque. Our institutional guidelines set a minimum amount of daily water intake. However, no study to date has determined whether that minimum amount is psychologically sufficient. In the present experiment, a monkey lived in an individual cage in which the only water available was delivered by chain pulling. A fixed number of responses was required for water delivery. This fixed ratio (FR) of responses per water delivery was progressively increased from FR 2 to FR 10. The study findings showed that during the FR 2 condition, demand for water was saturated at 131.3 ml/kg body weight (BW) (ranging from 95.1 to 211.2). The monkey's daily intake of water decreased as FR size incrementally increased, approaching an asymptote under the FR 8 and FR 10 conditions. During the FR 8 and FR 10 conditions, responding ceased when this monkey earned 53.5 ml/kg-BW (ranging from 32.7 to 74.9) of water. Therefore, the amount of water obtained under these conditions might provide a psychologically satisfying amount. Although these values were obtained from the behavioral study of one monkey, they were almost equivalent to values in our institutional guidelines that were determined by veterinary observations. These findings imply that behavioral economics is useful for studying the welfare of laboratory animals.

AGN jet power, formation of X-ray cavities, and FR I/II dichotomy in galaxy clusters

NASA Astrophysics Data System (ADS)

Fujita, Yutaka; Kawakatu, Nozomu; Shlosman, Isaac

2016-04-01

We investigate the ability of jets in active galactic nuclei to break out of the ambient gas with sufficiently large advance velocities. Using observationally estimated jet power, we analyze 28 bright elliptical galaxies in nearby galaxy clusters. Because the gas density profiles in the innermost regions of galaxies have not been resolved so far, we consider two extreme cases for temperature and density profiles. We also follow two types of evolution for the jet cocoons: being driven by the pressure inside the cocoon [Fanaroff-Riley (FR) type I], and being driven by the jet momentum (FR type II). Our main result is that regardless of the assumed form of the density profiles, jets with observed powers of ≲1044 erg s-1 are not powerful enough to evolve as FR II sources. Instead, they evolve as FR I sources and appear to be decelerated below the buoyant velocities of the cocoons when jets were propagating through the central dense regions of the host galaxies. This explains why FR I sources are more frequent than FR II sources in clusters. Furthermore, we predict the sizes of X-ray cavities from the observed jet powers and compare them with the observed ones-they are consistent within a factor of two if the FR I type evolution is realized. Finally, we find that the jets with a power ≳1044 erg s-1 are less affected by the ambient medium, and some of them, but not all, could serve as precursors of the FR II sources.

78 FR 31417 - National Priorities List, Final Rule No. 56

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-24

..., 1445 Ross Avenue, Suite 1200, Mailcode 6SFTS, Dallas, TX 75202-2733; 214/ 665-7436. Michelle Quick... Federal Register (48 FR 40674, September 8, 1983 and 53 FR 23988, June 24, 1988). The EPA is adding the...

47 CFR 0.601 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... this subpart each item on the agenda of a meeting is considered a meeting or a portion of a meeting. [42 FR 12867, Mar. 7, 1977, as amended at 48 FR 56391, Dec. 21, 1983; 64 FR 2149, Jan. 13, 1999] ...

47 CFR 0.601 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... this subpart each item on the agenda of a meeting is considered a meeting or a portion of a meeting. [42 FR 12867, Mar. 7, 1977, as amended at 48 FR 56391, Dec. 21, 1983; 64 FR 2149, Jan. 13, 1999] ...

47 CFR 0.601 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... this subpart each item on the agenda of a meeting is considered a meeting or a portion of a meeting. [42 FR 12867, Mar. 7, 1977, as amended at 48 FR 56391, Dec. 21, 1983; 64 FR 2149, Jan. 13, 1999] ...

47 CFR 0.601 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... this subpart each item on the agenda of a meeting is considered a meeting or a portion of a meeting. [42 FR 12867, Mar. 7, 1977, as amended at 48 FR 56391, Dec. 21, 1983; 64 FR 2149, Jan. 13, 1999] ...

47 CFR 0.601 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... this subpart each item on the agenda of a meeting is considered a meeting or a portion of a meeting. [42 FR 12867, Mar. 7, 1977, as amended at 48 FR 56391, Dec. 21, 1983; 64 FR 2149, Jan. 13, 1999] ...

40 CFR 85.2231 - On-board diagnostic test equipment requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

.../code_of_federal_regulations/ibr_locations.html. (b) The test system shall be capable of communicating..._locations.html. (d) [Reserved] [61 FR 40948, Aug. 6, 1996, as amended at 63 FR 24434, May 4, 1998; 66 FR...

16 CFR 1211.2 - Definition.

Code of Federal Regulations, 2010 CFR

2010-01-01

... incorporation by reference was approved by the Director of the Federal Register in accordance with 5 U.S.C. 552..._regulations/ibr_locations.html. [57 FR 60455, Dec. 21, 1992, as amended at 62 FR 46667, Sept. 4, 1997; 65 FR...

48 CFR 3.502-2 - Subcontractor kickbacks.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... 8703(b)). [52 FR 6121, Feb. 27, 1987; 52 FR 9989, Mar. 27, 1987, as amended at 53 FR 34226, Sept. 2... contract price charged by a prime contractor to the United States. (b) Imposes criminal penalties on any...

14 CFR 135.149 - Equipment requirements: General.

Code of Federal Regulations, 2010 CFR

2010-01-01

.... 135-1, 44 FR 26737, May 7, 1979; Amdt. 135-34, 54 FR 43926, Oct. 27, 1989; Amdt. 135-38, 55 FR 43310... REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Aircraft and...

14 CFR 135.149 - Equipment requirements: General.

Code of Federal Regulations, 2014 CFR

2014-01-01

.... 135-1, 44 FR 26737, May 7, 1979; Amdt. 135-34, 54 FR 43926, Oct. 27, 1989; Amdt. 135-38, 55 FR 43310... REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Aircraft and...

14 CFR 135.149 - Equipment requirements: General.

Code of Federal Regulations, 2013 CFR

2013-01-01

.... 135-1, 44 FR 26737, May 7, 1979; Amdt. 135-34, 54 FR 43926, Oct. 27, 1989; Amdt. 135-38, 55 FR 43310... REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Aircraft and...

14 CFR 135.149 - Equipment requirements: General.

Code of Federal Regulations, 2012 CFR

2012-01-01

.... 135-1, 44 FR 26737, May 7, 1979; Amdt. 135-34, 54 FR 43926, Oct. 27, 1989; Amdt. 135-38, 55 FR 43310... REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Aircraft and...

14 CFR 135.149 - Equipment requirements: General.

Code of Federal Regulations, 2011 CFR

2011-01-01

.... 135-1, 44 FR 26737, May 7, 1979; Amdt. 135-34, 54 FR 43926, Oct. 27, 1989; Amdt. 135-38, 55 FR 43310... REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Aircraft and...

40 CFR 52.786 - Inspection and maintenance program.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 38, Jan. 2, 1981; 51 FR 40677, Nov. 7, 1986; 55 FR 31052, July 31, 1990; 58 FR 62535, Nov. 29, 1993] ..., commitment to timely adopt and implement enhanced inspection and maintenance (I/M) rules for Lake and Porter...

76 FR 34252 - Notice Pursuant to the National Cooperative Research and Production Act of 1993; Portland Cement...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-13

...; Argos USA Corporation, Houston, TX; Penta Engineering Corporation, St. Louis, MO; and Schreiber Yonley... March 7, 2011 (76 FR 12370). Patricia A. Brink, Director of Civil Enforcement, Antitrust Division. [FR...

78 FR 51058 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-20

... below the center wing box between frame (FR) 40 and FR 42, and in part of the area of the upper... NDT inspections for cracks in the affected areas of the keel beam side panel below the center wing box...

49 CFR 570.9 - Tires.

Code of Federal Regulations, 2012 CFR

2012-10-01

... shall not be exposed, either to the naked eye or when cuts or abrasions on the tire are probed. (1... probe cuts or abrasions. [38 FR 23950, Sept. 5, 1973, as amended at 39 FR 12868, Apr. 9, 1974; 39 FR...

49 CFR 570.9 - Tires.

Code of Federal Regulations, 2014 CFR

2014-10-01

... shall not be exposed, either to the naked eye or when cuts or abrasions on the tire are probed. (1... probe cuts or abrasions. [38 FR 23950, Sept. 5, 1973, as amended at 39 FR 12868, Apr. 9, 1974; 39 FR...

49 CFR 570.9 - Tires.

Code of Federal Regulations, 2011 CFR

2011-10-01

... shall not be exposed, either to the naked eye or when cuts or abrasions on the tire are probed. (1... probe cuts or abrasions. [38 FR 23950, Sept. 5, 1973, as amended at 39 FR 12868, Apr. 9, 1974; 39 FR...

49 CFR 570.9 - Tires.

Code of Federal Regulations, 2010 CFR

2010-10-01

... shall not be exposed, either to the naked eye or when cuts or abrasions on the tire are probed. (1... probe cuts or abrasions. [38 FR 23950, Sept. 5, 1973, as amended at 39 FR 12868, Apr. 9, 1974; 39 FR...

49 CFR 570.9 - Tires.

Code of Federal Regulations, 2013 CFR

2013-10-01

... shall not be exposed, either to the naked eye or when cuts or abrasions on the tire are probed. (1... probe cuts or abrasions. [38 FR 23950, Sept. 5, 1973, as amended at 39 FR 12868, Apr. 9, 1974; 39 FR...

47 CFR 90.5 - Other applicable rule parts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Offices. (b) Part 1 includes rules of practice and procedure for the filing of applications for stations... microwave services. [43 FR 54791, Nov. 22, 1978, as amended at 50 FR 39677, Sept. 30, 1985; 55 FR 20398, May...

31 CFR 341.10 - Reissue.

Code of Federal Regulations, 2012 CFR

2012-07-01

... the case of a bond registered in beneficiary form upon the owner's request on Form PD 3564. No consent..., Parkersburg, WV 26101. [28 FR 405, Jan 16, 1963, as amended at 42 FR 21611, Apr. 28, 1977; 42 FR 57123, Nov. 1...

31 CFR 341.10 - Reissue.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the case of a bond registered in beneficiary form upon the owner's request on Form PD 3564. No consent..., Parkersburg, WV 26101. [28 FR 405, Jan 16, 1963, as amended at 42 FR 21611, Apr. 28, 1977; 42 FR 57123, Nov. 1...

31 CFR 341.10 - Reissue.

Code of Federal Regulations, 2011 CFR

2011-07-01

... the case of a bond registered in beneficiary form upon the owner's request on Form PD 3564. No consent..., Parkersburg, WV 26101. [28 FR 405, Jan 16, 1963, as amended at 42 FR 21611, Apr. 28, 1977; 42 FR 57123, Nov. 1...

47 CFR 74.751 - Modification of transmission systems.

Code of Federal Regulations, 2013 CFR

2013-10-01

...: Video Division, Media Bureau, is notified in writing upon the completion of such changes. (d) Upon..., Nov. 1, 1974; 45 FR 26067, Apr. 17, 1980; 47 FR 21501, May 18, 1982; 48 FR 41423, Sept. 15, 1983; 50...

47 CFR 74.751 - Modification of transmission systems.

Code of Federal Regulations, 2010 CFR

2010-10-01

...: Video Division, Media Bureau, is notified in writing upon the completion of such changes. (d) Upon..., Nov. 1, 1974; 45 FR 26067, Apr. 17, 1980; 47 FR 21501, May 18, 1982; 48 FR 41423, Sept. 15, 1983; 50...

47 CFR 74.751 - Modification of transmission systems.

Code of Federal Regulations, 2012 CFR

2012-10-01

...: Video Division, Media Bureau, is notified in writing upon the completion of such changes. (d) Upon..., Nov. 1, 1974; 45 FR 26067, Apr. 17, 1980; 47 FR 21501, May 18, 1982; 48 FR 41423, Sept. 15, 1983; 50...

47 CFR 74.751 - Modification of transmission systems.

Code of Federal Regulations, 2011 CFR

2011-10-01

...: Video Division, Media Bureau, is notified in writing upon the completion of such changes. (d) Upon..., Nov. 1, 1974; 45 FR 26067, Apr. 17, 1980; 47 FR 21501, May 18, 1982; 48 FR 41423, Sept. 15, 1983; 50...

47 CFR 74.751 - Modification of transmission systems.

Code of Federal Regulations, 2014 CFR

2014-10-01

...: Video Division, Media Bureau, is notified in writing upon the completion of such changes. (d) Upon..., Nov. 1, 1974; 45 FR 26067, Apr. 17, 1980; 47 FR 21501, May 18, 1982; 48 FR 41423, Sept. 15, 1983; 50...

29 CFR 4.55 - Issuance and revision of wage determinations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... for all bidders so none will be placed at a competitive disadvantage. (c) Determinations issued by the... competitive disadvantage. [48 FR 49762, Oct. 27, 1983. Redesignated at 61 FR 68664, Dec. 30, 1996; 70 FR 50898...

40 CFR 52.1070 - Identification of plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Revised .14B(1). 26.11.06.15 Nitrogen Oxides from Nitric Acid Plants 8/1/88 11/3/92, 57 FR 49651 (c)(90)(i... Requirements 12/17/07 6/11/13; 78 FR 34911 26.11.34.07 Initial NMOG Credit Account Balances 12/17/07 6/11/13... Credit Account Balances 12/17/07 6/11/13; 78 FR 34911 26.11.34.11 Vehicle Testing 12/17/07 6/11/13; 78 FR...

40 CFR 52.570 - Identification of plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) Incinerators 6/15/98 12/2/99, 64 FR 67491 391-3-1-.02(2)(d) Fuel-burning Equipment 7/20/05 2/9/09, 75 FR 6309... Concrete Hot Mix Plants 1/17/79 9/18/79, 44 FR 54047 391-3-1-.02(2)(l) Conical Burners 1/17/79 9/18/79, 44... Emissions from Fuel-burning Equipment 2/16/00 7/10/01, 66 FR 35906 391-3-1-.02(2)(mmm) NOX Emissions from...

Visual and semi-automatic non-invasive detection of interictal fast ripples: A potential biomarker of epilepsy in children with tuberous sclerosis complex.

PubMed

Bernardo, Danilo; Nariai, Hiroki; Hussain, Shaun A; Sankar, Raman; Salamon, Noriko; Krueger, Darcy A; Sahin, Mustafa; Northrup, Hope; Bebin, E Martina; Wu, Joyce Y

2018-04-03

We aim to establish that interictal fast ripples (FR; 250-500 Hz) are detectable on scalp EEG, and to investigate their association to epilepsy. Scalp EEG recordings of a subset of children with tuberous sclerosis complex (TSC)-associated epilepsy from two large multicenter observational TSC studies were analyzed and compared to control children without epilepsy or any other brain-based diagnoses. FR were identified both by human visual review and compared with semi-automated review utilizing a deep learning-based FR detector. Seven out of 7 children with TSC-associated epilepsy had scalp FR compared to 0 out of 4 children in the control group (p = 0.003). The automatic detector has a sensitivity of 98% and false positive rate with average of 11.2 false positives per minute. Non-invasive detection of interictal scalp FR was feasible, by both visual and semi-automatic detection. Interictal scalp FR occurred exclusively in children with TSC-associated epilepsy and were absent in controls without epilepsy. The proposed detector achieves high sensitivity of FR detection; however, expert review of the results to reduce false positives is advised. Interictal FR are detectable on scalp EEG and may potentially serve as a biomarker of epilepsy in children with TSC. Copyright © 2018 International Federation of Clinical Neurophysiology. All rights reserved.

Folate receptor {alpha} regulates cell proliferation in mouse gonadotroph {alpha}T3-1 cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yao, Congjun; Evans, Chheng-Orn; Stevens, Victoria L.

We have previously found that the mRNA and protein levels of the folate receptor alpha (FR{alpha}) are uniquely over-expressed in clinically human nonfunctional (NF) pituitary adenomas, but the mechanistic role of FR{alpha} has not fully been determined. We investigated the effect of FR{alpha} over-expression in the mouse gonadotroph {alpha}T3-1 cell line as a model for NF pituitary adenomas. We found that the expression and function of FR{alpha} were strongly up-regulated, by Western blotting and folic acid binding assay. Furthermore, we found a higher cell growth rate, an enhanced percentage of cells in S-phase by BrdU assay, and a higher PCNAmore » staining. These observations indicate that over-expression of FR{alpha} promotes cell proliferation. These effects were abrogated in the same {alpha}T3-1 cells when transfected with a mutant FR{alpha} cDNA that confers a dominant-negative phenotype by inhibiting folic acid binding. Finally, by real-time quantitative PCR, we found that mRNA expression of NOTCH3 was up-regulated in FR{alpha} over-expressing cells. In summary, our data suggests that FR{alpha} regulates pituitary tumor cell proliferation and mechanistically may involve the NOTCH pathway. Potentially, this finding could be exploited to develop new, innovative molecular targeted treatment for human NF pituitary adenomas.« less

38 CFR 3.160 - Status of claims.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., whichever is the earlier. (See §§ 20.1103 and 20.1104 of this chapter.) (e) Reopened claim. Any application..., as amended at 31 FR 12056, Sept. 15, 1966; 55 FR 20148, May 15, 1990; 58 FR 32445, June 10, 1993] ...

75 FR 34108 - National Grid USA; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-16

.... 707, 73 FR 11013 (Feb. 29, 2008), FERC Stats. & Regs. ] 31,264, at P 4-5, order on rehearing, Order No. 707-A, 73 FR 43072 (Jul. 24, 2008), FERC Stats. & Regs. ] 31,272 (2008). Any person desiring to...

40 CFR 61.01 - Lists of pollutants and applicability of part 61.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) Chromium (50 FR 24317; June 10, 1985) Copper (52 FR 5496; Feb. 23, 1987) Epichlorohydrin (50 FR 24575; June... stationary sources by an authorized State air pollution control agency or by the Administrator of the U.S...

40 CFR 61.01 - Lists of pollutants and applicability of part 61.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) Chromium (50 FR 24317; June 10, 1985) Copper (52 FR 5496; Feb. 23, 1987) Epichlorohydrin (50 FR 24575; June... stationary sources by an authorized State air pollution control agency or by the Administrator of the U.S...

77 FR 12056 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-28

... proposed to the FR 2644; however, going forward, the Federal Reserve will modify the FR 2644 instructions... agreement corporations. Data from this reporting form comprise a piece of the flow of funds data that are...

77 FR 73676 - Notice Pursuant to the National Cooperative Research and Production Act of 1993; National...

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2012-12-11

..., Morgan Hill, CA; and Waltonen Engineering, Inc., Warren, MI, have been added as parties to this venture... September 5, 2012 (77 FR 54611). Patricia A. Brink, Director of Civil Enforcement, Antitrust Division. [FR...

49 CFR 192.63 - Marking of materials.

Code of Federal Regulations, 2011 CFR

2011-10-01

... thermoplastic fittings must be marked in accordance with ASTM D2513-87 (incorporated by reference, see § 192.7.... 9, 1989; 58 FR 14521, Mar. 18, 1993; Amdt. 192-76, 61 FR 26122, May 24, 1996; 61 FR 36826, July 15...

77 FR 46114 - Notice of Intent To Repatriate Cultural Items: Peabody Museum of Archaeology and Ethnology...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-02

... Repatriate (NIR) published in the Federal Register (73 FR 58619-58620, October 7, 2008), which itself corrected an earlier NIR published in the Federal Register (72 FR 41522-41524, July 30, 2007). After...

47 CFR 80.271 - Technical requirements for portable survival craft radiotelephone transceivers.

Code of Federal Regulations, 2011 CFR

2011-10-01

...:9 with no significant adverse effect upon the performance of the device; (5) The transceivers must... Commission's database. [51 FR 31213, Sept. 2, 1986, as amended at 63 FR 36607, July 7, 1998; 73 FR 4483, Jan...

47 CFR 74.731 - Purpose and permissible service.

Code of Federal Regulations, 2011 CFR

2011-10-01

... of a video and audio feed, in which case modulating equipment meeting the requirements of § 74.750(d..., Jan. 13, 1978; 47 FR 21499, May 18, 1982; 47 FR 40172, Sept. 13, 1982; 48 FR 21487, May 12, 1983; 52...

47 CFR 74.731 - Purpose and permissible service.

Code of Federal Regulations, 2010 CFR

2010-10-01

... of a video and audio feed, in which case modulating equipment meeting the requirements of § 74.750(d..., as amended at 43 FR 1951, Jan. 13, 1978; 47 FR 21499, May 18, 1982; 47 FR 40172, Sept. 13, 1982; 48...

47 CFR 73.1560 - Operating power and mode tolerances.

Code of Federal Regulations, 2010 CFR

2010-10-01

...: Audio Division (radio) or Video Division (television), Media Bureau, not later than the 10th day of the.... [44 FR 58734, Oct. 11, 1979, as amended at 49 FR 22093, May 25, 1984; 49 FR 29069, July 18, 1984; 49...

47 CFR 74.731 - Purpose and permissible service.

Code of Federal Regulations, 2013 CFR

2013-10-01

... of a video and audio feed, in which case modulating equipment meeting the requirements of § 74.750(d..., Jan. 13, 1978; 47 FR 21499, May 18, 1982; 47 FR 40172, Sept. 13, 1982; 48 FR 21487, May 12, 1983; 52...

47 CFR 73.1560 - Operating power and mode tolerances.

Code of Federal Regulations, 2012 CFR

2012-10-01

...: Audio Division (radio) or Video Division (television), Media Bureau, not later than the 10th day of the.... [44 FR 58734, Oct. 11, 1979, as amended at 49 FR 22093, May 25, 1984; 49 FR 29069, July 18, 1984; 49...

47 CFR 74.731 - Purpose and permissible service.

Code of Federal Regulations, 2012 CFR

2012-10-01

... of a video and audio feed, in which case modulating equipment meeting the requirements of § 74.750(d..., Jan. 13, 1978; 47 FR 21499, May 18, 1982; 47 FR 40172, Sept. 13, 1982; 48 FR 21487, May 12, 1983; 52...

47 CFR 73.1560 - Operating power and mode tolerances.

Code of Federal Regulations, 2011 CFR

2011-10-01

...: Audio Division (radio) or Video Division (television), Media Bureau, not later than the 10th day of the.... [44 FR 58734, Oct. 11, 1979, as amended at 49 FR 22093, May 25, 1984; 49 FR 29069, July 18, 1984; 49...

47 CFR 73.1560 - Operating power and mode tolerances.

Code of Federal Regulations, 2013 CFR

2013-10-01

...: Audio Division (radio) or Video Division (television), Media Bureau, not later than the 10th day of the.... [44 FR 58734, Oct. 11, 1979, as amended at 49 FR 22093, May 25, 1984; 49 FR 29069, July 18, 1984; 49...

47 CFR 74.731 - Purpose and permissible service.

Code of Federal Regulations, 2014 CFR

2014-10-01

... of a video and audio feed, in which case modulating equipment meeting the requirements of § 74.750(d..., Jan. 13, 1978; 47 FR 21499, May 18, 1982; 47 FR 40172, Sept. 13, 1982; 48 FR 21487, May 12, 1983; 52...

47 CFR 73.1560 - Operating power and mode tolerances.

Code of Federal Regulations, 2014 CFR

2014-10-01

...: Audio Division (radio) or Video Division (television), Media Bureau, not later than the 10th day of the.... [44 FR 58734, Oct. 11, 1979, as amended at 49 FR 22093, May 25, 1984; 49 FR 29069, July 18, 1984; 49...

Exposure to lower red to far-red light ratios improve tomato tolerance to salt stress.

PubMed

Cao, Kai; Yu, Jie; Xu, Dawei; Ai, Kaiqi; Bao, Encai; Zou, Zhirong

2018-05-24

Red (R) and far-red (FR) light distinctly influence phytochrome-mediated initial tomato growth and development, and more recent evidence indicates that these spectra also modulate responses to a multitude of abiotic and biotic stresses. This research investigated whether different R: FR values affect tomato growth response and salinity tolerance. Tomato seedlings were exposed to different R: FR conditions (7.4, 1.2 and 0.8) under salinity stress (100 mM NaCl), and evaluated for their growth, biochemical changes, active reactive oxygen species (ROS) and ROS scavenging enzymes, pigments, rate of photosynthesis, and chlorophyll fluorescence. The results showed that under conditions of salinity, tomato seedlings subjected to a lower R: FR value (0.8) significantly increased both their growth, proline content, chlorophyll content and net photosynthesis rate (Pn), while they decreased malondialdehyde (MDA) compared to the higher R: FR value (7.4). Under conditions of salinity, the lower R: FR value caused a decrease in both the superoxide anion (O 2 •- ) and in hydrogen peroxide (H 2 O 2 ) generation, an increase in the activities of superoxidase dismutase (SOD, EC 1.15.1.1), peroxidase (POD, EC 1.11.1.7) and catalase (CAT, EC 1.11.1.7). Tomato seedlings grown under the lower R: FR value and conditions of salinity showed a higher actual quantum yield of photosynthesis (ΦPSII), electron transport rate (ETR), and photochemical quenching (qP) than those exposed to a higher R: FR, indicating overall healthier growth. However, the salinity tolerance induced at the lower R: FR condition disappeared in the tomato phyB1 mutant. These results suggest that growing tomato with a lower R: FR value could improve seedlings' salinity tolerance, and phytochrome B1 play an very important role in this process. Therefore, different qualities of light can be used to efficiently develop abiotic stress tolerance in tomato cultivation.

Precursors of developmental dyslexia: an overview of the longitudinal Dutch Dyslexia Programme study.

PubMed

van der Leij, Aryan; van Bergen, Elsje; van Zuijen, Titia; de Jong, Peter; Maurits, Natasha; Maassen, Ben

2013-11-01

Converging evidence suggests that developmental dyslexia is a neurobiological disorder, characterized by deficits in the auditory, visual, and linguistic domains. In the longitudinal project of the Dutch Dyslexia Programme, 180 children with a familial risk of dyslexia (FR) and a comparison group of 120 children without FR (noFR) were followed from the age of 2 months up to 9 years. Children were assessed on (1) auditory, speech, and visual event-related potentials every half year between 2 and 41 months; (2) expressive and receptive language, motor development, behaviour problems, and home-literacy environment by questionnaires at the age of 2 and 3; (3) speech-language and cognitive development from 47 months onwards; and (4) preliteracy and subskills of reading, and reading development during kindergarten and Grades 2 and 3. With regard to precursors of reading disability, first analyses showed specific differences between FR and noFR children in neurophysiological, cognitive, and early language measures. Once reading tests administered from age 7 to 9 years were available, the children were divided into three groups: FR children with and without dyslexia, and controls. Analyses of the differences between reading groups yielded distinct profiles and developmental trajectories. On early speech and visual processing, and several cognitive measures, performance of the non-dyslexic FR group differed from the dyslexic FR group and controls, indicating continuity of the influence of familial risk. Parental reading and rapid naming skills appeared to indicate their offspring's degree of familial risk. Furthermore, on rapid naming and nonverbal IQ, the non-dyslexic FR group performed similarly to the controls, suggesting protective factors. There are indications of differences between the FR and control groups, irrespective of reading outcome. These results contribute to the distinction between the deficits correlated to dyslexia as a manifest reading disorder and deficits correlated to familial risk only. Copyright © 2013 John Wiley & Sons, Ltd.

76 FR 59990 - Endangered and Threatened Wildlife and Plants; Revised Endangered Status, Revised Critical...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-28

...), concerning the Service's delisting of the Northern Rocky Mountain gray wolf (74 FR 15123, Apr. 12, 2009); and... Service's 2008 finding on a petition to list the Gunnison's prairie dog (73 FR 6660, Feb. 5, 2008). The...

78 FR 61348 - Electricity Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-03

... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Department of Energy. ACTION: Notice of Cancellation of Open Meeting. SUMMARY: On September 11, 2013, in FR Doc. 2013-22119, on pages... October 2-3, 2013 of the Electricity Advisory Committee (78 FR 55692). This notice announces the...

40 CFR 52.1820 - Identification of plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

.../98, 63 FR 45722 33-15-01-14 Time schedule for compliance 10/1/87 5/12/89, 54 FR 20574 33-15-01-15... 4/6/12, 77 FR 20894 American Crystal Sugar at Drayton SIP Chapter 8, Section 8.3, Continuous...

48 CFR 212.7002-1 - Contracts under the program.

Code of Federal Regulations, 2013 CFR

2013-10-01

... item or process that does not meet the definition of “commercial item,” if the contract— (1) Is awarded... computer software. [69 FR 63330, Nov. 1, 2004, as amended at 71 FR 18669, Apr. 12, 2006; 73 FR 21845, Apr...

48 CFR 212.7002-1 - Contracts under the program.

Code of Federal Regulations, 2014 CFR

2014-10-01

... item or process that does not meet the definition of “commercial item,” if the contract— (1) Is awarded... computer software. [69 FR 63330, Nov. 1, 2004, as amended at 71 FR 18669, Apr. 12, 2006; 73 FR 21845, Apr...

48 CFR 212.7002-1 - Contracts under the program.

Code of Federal Regulations, 2011 CFR

2011-10-01

... item or process that does not meet the definition of “commercial item,” if the contract— (1) Is awarded... computer software. [69 FR 63330, Nov. 1, 2004, as amended at 71 FR 18669, Apr. 12, 2006; 73 FR 21845, Apr...

48 CFR 212.7002-1 - Contracts under the program.

Code of Federal Regulations, 2012 CFR

2012-10-01

... item or process that does not meet the definition of “commercial item,” if the contract— (1) Is awarded... computer software. [69 FR 63330, Nov. 1, 2004, as amended at 71 FR 18669, Apr. 12, 2006; 73 FR 21845, Apr...

76 FR 50881 - Required Scale Tests

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-17

... RIN 0580-AB10 Required Scale Tests AGENCY: Grain Inspection, Packers and Stockyards Administration... required scale tests. Those documents defined ``limited seasonal basis'' incorrectly. This document... 20, 2011 (76 FR 3485) and on April 4, 2011 (76 FR 18348), concerning required scale tests. Those...

47 CFR 73.1010 - Cross reference to rules in other parts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Auxiliary Stations”; (5) Subpart G, “Low Power TV, TV Translator and TV Booster Stations”; (6) Subpart H... Booster Stations”. [53 FR 2498, Jan. 28, 1988, as amended at 57 FR 48333, Oct. 23, 1992; 60 FR 55480, Nov...

47 CFR 73.1010 - Cross reference to rules in other parts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Auxiliary Stations”; (5) Subpart G, “Low Power TV, TV Translator and TV Booster Stations”; (6) Subpart H... Booster Stations”. [53 FR 2498, Jan. 28, 1988, as amended at 57 FR 48333, Oct. 23, 1992; 60 FR 55480, Nov...

47 CFR 73.1010 - Cross reference to rules in other parts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Auxiliary Stations”; (5) Subpart G, “Low Power TV, TV Translator and TV Booster Stations”; (6) Subpart H... Booster Stations”. [53 FR 2498, Jan. 28, 1988, as amended at 57 FR 48333, Oct. 23, 1992; 60 FR 55480, Nov...

47 CFR 73.1010 - Cross reference to rules in other parts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Auxiliary Stations”; (5) Subpart G, “Low Power TV, TV Translator and TV Booster Stations”; (6) Subpart H... Booster Stations”. [53 FR 2498, Jan. 28, 1988, as amended at 57 FR 48333, Oct. 23, 1992; 60 FR 55480, Nov...

47 CFR 73.1010 - Cross reference to rules in other parts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Auxiliary Stations”; (5) Subpart G, “Low Power TV, TV Translator and TV Booster Stations”; (6) Subpart H... Booster Stations”. [53 FR 2498, Jan. 28, 1988, as amended at 57 FR 48333, Oct. 23, 1992; 60 FR 55480, Nov...

21 CFR 1.231 - How and where do you register?

Code of Federal Regulations, 2014 CFR

2014-04-01

... writing to the U.S. Food and Drug Administration (HFS-681), 5600 Fishers Lane, Rockville, MD 20857 or by... (Roman) alphabet. [68 FR 58960, Oct. 10, 2003, as amended at 69 FR 29428, May 24, 2004; 73 FR 15883, Mar...

21 CFR 1.231 - How and where do you register?

Code of Federal Regulations, 2013 CFR

2013-04-01

... writing to the U.S. Food and Drug Administration (HFS-681), 5600 Fishers Lane, Rockville, MD 20857 or by... (Roman) alphabet. [68 FR 58960, Oct. 10, 2003, as amended at 69 FR 29428, May 24, 2004; 73 FR 15883, Mar...

21 CFR 1.231 - How and where do you register?

Code of Federal Regulations, 2012 CFR

2012-04-01

... writing to the U.S. Food and Drug Administration (HFS-681), 5600 Fishers Lane, Rockville, MD 20857 or by... (Roman) alphabet. [68 FR 58960, Oct. 10, 2003, as amended at 69 FR 29428, May 24, 2004; 73 FR 15883, Mar...

21 CFR 1.231 - How and where do you register?

Code of Federal Regulations, 2010 CFR

2010-04-01

... writing to the U.S. Food and Drug Administration (HFS-681), 5600 Fishers Lane, Rockville, MD 20857 or by... (Roman) alphabet. [68 FR 58960, Oct. 10, 2003, as amended at 69 FR 29428, May 24, 2004; 73 FR 15883, Mar...

21 CFR 1.231 - How and where do you register?

Code of Federal Regulations, 2011 CFR

2011-04-01

... writing to the U.S. Food and Drug Administration (HFS-681), 5600 Fishers Lane, Rockville, MD 20857 or by... (Roman) alphabet. [68 FR 58960, Oct. 10, 2003, as amended at 69 FR 29428, May 24, 2004; 73 FR 15883, Mar...

30 CFR 735.15 - Amount of grants.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., 501, 503, 705, Pub. L. 95-87, 91 Stat. 450, 467, 470, 520 (30 U.S.C. 1211, 1251, 1253, 1295)) [42 FR 62706, Dec. 13, 1977. Redesignated at 44 FR 15312, Mar. 13, 1979, and amended at 45 FR 2804, Jan. 14...

78 FR 54454 - Open Meeting of the Information Security and Privacy Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-04

... include the following items: --Cybersecurity Executive Order 13636, Improving Critical Infrastructure Cybersecurity (78 FR 11737, February 19, 2013); Development of New Cybersecurity Framework; Request for Information (RFI)--Developing a Framework to Improve Critical Infrastructure Cybersecurity (78 FR 13024...

75 FR 33166 - Extension of Expiration Dates for Several Body System Listings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-11

... Impairment, Hematological Disorders, Musculoskeletal System, Mental Disorders, Neurological, and Respiratory... be effective: Growth Impairment (100.00); Respiratory System (3.00 and 103.00); Hematological... listings (70 FR 53323 (2005)), the respiratory listings (70 FR 19358 (2005)), the cardiovascular listings...

47 CFR 76.952 - Information to be provided by cable operator on monthly subscriber bills.

Code of Federal Regulations, 2010 CFR

2010-10-01

... and phone number of the franchising authority, unless the franchising authority in writing requests... system. [58 FR 29753, May 21, 1993, as amended at 59 FR 17960, Apr. 15, 1994; 64 FR 35950, July 2, 1999] ...

78 FR 21183 - Persons on Whom Sanctions Have Been Imposed Under the Iran Sanctions Act of 1996 and the Iran...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-09

...: On general issues: Office of Sanctions Policy and Implementation, Department of State, Telephone... FR 56866, September 14, 2011) --Petro[acute]leos de Venezuela S.A. (see Public Notice 7585, 76 FR...

Military Uniforms: Issues Related to the Supply of Flame Resistant Fibers for the Production of Military Uniforms

DTIC Science & Technology

2011-06-30

fibers. A variety of fibers may be used to create a fabric blend, including FR rayon, Nomex®, Twaron®, Kevlar®, FR cotton, polybenzimidazole ( PBI ...as meta-aramids (e.g., Nomex®), modacrylic, PBI , and FR-treated cotton. o For example, the Army is currently testing fabrics in an attempt to...considering fabric blends containing FR-treated cotton as a potential alternative. o The Marine Corps uses PBI fibers in its balaclava (a protective

Wormhole solutions in f(R) gravity satisfying energy conditions

NASA Astrophysics Data System (ADS)

Mazharimousavi, S. Habib; Halilsoy, M.

2016-10-01

Without reference to exotic sources construction of viable wormholes in Einstein’s general relativity remained ever a myth. With the advent of modified theories, however, specifically the f(R) theory, new hopes arose for the possibility of such objects. From this token, we construct traversable wormholes in f(R) theory supported by a fluid source which respects at least the weak energy conditions. We provide an example (Example 1) of asymptotically flat wormhole in f(R) gravity without ghosts.

Fructose liquid and solid formulations differently affect gut integrity, microbiota composition and related liver toxicity: a comparative in vivo study.

PubMed

Mastrocola, Raffaella; Ferrocino, Ilario; Liberto, Erica; Chiazza, Fausto; Cento, Alessia Sofia; Collotta, Debora; Querio, Giulia; Nigro, Debora; Bitonto, Valeria; Cutrin, Juan Carlos; Rantsiou, Kalliopi; Durante, Mariaconcetta; Masini, Emanuela; Aragno, Manuela; Cordero, Chiara; Cocolin, Luca; Collino, Massimo

2018-05-01

Despite clinical findings suggesting that the form (liquid versus solid) of the sugars may significantly affect the development of metabolic diseases, no experimental data are available on the impact of their formulations on gut microbiota, integrity and hepatic outcomes. In the present sudy, C57Bl/6j mice were fed a standard diet plus water (SD), a standard diet plus 60% fructose syrup (L-Fr) or a 60% fructose solid diet plus water (S-Fr) for 12 weeks. Gut microbiota was characterized through 16S rRNA phylogenetic profiling and shotgun sequencing of microbial genes in ileum content and related volatilome profiling. Fructose feeding led to alterations of the gut microbiota depending on the fructose formulation, with increased colonization by Clostridium, Oscillospira and Clostridiales phyla in the S-Fr group and Bacteroides, Lactobacillus, Lachnospiraceae and Dorea in the L-Fr. S-Fr evoked the highest accumulation of advanced glycation end products and barrier injury in the ileum intestinal mucosa. These effects were associated to a stronger activation of the lipopolysaccharide-dependent proinflammatory TLR4/NLRP3 inflammasome pathway in the liver of S-Fr mice than of L-Fr mice. In contrast, L-Fr intake induced higher levels of hepatosteatosis and markers of fibrosis than S-Fr. Fructose-induced ex novo lipogenesis with production of SCFA and MCFA was confirmed by metagenomic analysis. These results suggest that consumption of fructose under different forms, liquid or solid, may differently affect gut microbiota, thus leading to impairment in intestinal mucosa integrity and liver homeostasis. Copyright © 2018 Elsevier Inc. All rights reserved.

Fructose-fed streptozotocin-injected rat: an alternative model for type 2 diabetes.

PubMed

Wilson, Rachel D; Islam, Md Shahidul

2012-01-01

The main objective of the study was to develop an alternative non-genetic rat model for type 2 diabetes (T2D). Six-week-old male Sprague-Dawley rats (190.56 ± 23.60 g) were randomly divided into six groups, namely: Normal Control (NC), Diabetic Control (DBC), Fructose-10 (FR10), Fructose-20 (FR20), Fructose-30 (FR30) and Fructose-40 (FR40) and were fed a normal rat pellet diet ad libitum for 2 weeks. During this period, the two control groups received normal drinking water whilst the fructose groups received 10, 20, 30 and 40% fructose in drinking water ad libitum, respectively. After two weeks of dietary manipulation, all groups except the NC group received a single injection (i.p.) of streptozotocin (STZ) (40 mg/kg b.w.) dissolved in citrate buffer (pH 4.4). The NC group received only a vehicle buffer injection (i.p.). One week after the STZ injection, animals with non-fasting blood glucose levels > 300 mg/dl were considered as diabetic. Three weeks after the STZ injection, the animals in FR20, FR30 and FR40 groups were eliminated from the study due to the severity of diabetes and the FR10 group was selected for the remainder of the 11 weeks experimental period. The significantly (p < 0.05) higher fluid intake, blood glucose, serum lipids, liver glycogen, liver function enzymes and insulin resistance (HOMA-IR) and significantly (p < 0.05) lower body weight, oral glucose tolerance, number of pancreatic β-cells and pancreatic β-cell functions (HOMA-β) of FR10 group demonstrate that the 10% fructose-fed followed by 40 mg/kg of BWSTZ injected rat can be a new and alternative model for T2D.