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Sample records for zhanna komkowa anton

  1. Anton Grdina Primary Achievement Program

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The Anton project presents a partnership between NASA Lewis, CMHA, and the Cleveland Public Schools. The intent of this project is to empower parents to work with their children in science and math activities.

  2. Die Kosmogonie Anton von Zachs.

    NASA Astrophysics Data System (ADS)

    Brosche, P.

    In his "Cosmogenische Betrachtungen" (1804), Anton von Zach rediscovered - probably independently - some aspects of the theories of Kant and Laplace. More originally, he envisaged also the consequences of an era of heavy impacts in the early history of the Earth.

  3. Registration of Anton Hard White Winter Wheat

    ‘Anton’ (Reg. No. CV PI 651043) hard white winter wheat (Triticum aestivum L.) was developed by the USDA-ARS and the Nebraska Agricultural Experiment Station and released in December, 2007. "Anton" was selected from the cross WA691213-27/N86L177//‘Platte’. Anton primarily was released for its lo...

  4. Anton-Babinski syndrome, case report.

    PubMed

    Martín Juan, A; Madrigal, R; Porta Etessam, J; Sáenz-Francés San Baldomero, F; Santos Bueso, E

    2018-05-30

    A 22 year-old woman complained about blurred vision after an episode of recovered cardiorespiratory arrest. She had bilateral low visual acuity («count fingers») and no ophthalmological or visual pathways changes. She also had an apparent lack of awareness of the deficit. The Magnetic Resonance Imaging (MRI) showed ischaemic changes in both occipital lobes. As a result, she was diagnosed with Anton-Babinski syndrome. This is a rare disease that should be suspected in strange or poorly congruent visual loss. It is usually due to an ischaemic injury in this region of brain, manifesting itself with low vision not perceived by the patient (visual confabulation). It can simulate a non-organic visual loss or psychiatric disease. Copyright © 2018 Sociedad Española de Oftalmología. Publicado por Elsevier España, S.L.U. All rights reserved.

  5. IN MEMORIAM: Hermann Anton Haus, 1925 2003

    NASA Astrophysics Data System (ADS)

    2004-08-01

    Photograph Hermann Anton Haus, an Institute Professor at the Massachusetts Institute of Technology (MIT), was to have been a Keynote Speaker at the Fluctuations and Noise in Photonics and Quantum Optics Conference, from which the papers in this special issue derive. Sadly, on May 21, 2003 - less than two weeks before the conference - Professor Haus succumbed to a heart attack after arriving home in Lexington, Massachusetts, from his regular, 15-mile commute by bicycle from MIT. He was 77. Throughout his lengthy and illustrious career, Professor Haus had repeatedly and very successfully addressed problems of fluctuations and noise, with special focus on the fundamental issues that arise in quantum optics. To honour Professor Haus' legacy to our technical community, this special issue of Journal of Optics B: Quantum and Semiclassical Optics is dedicated to his memory. Professor Haus was born in Ljubljana, Slovenia, in the former Yugoslavia, on 8 August 1925. After attending the Technische Hochschule, Graz, and the Technische Hochschule, Wien, in Austria, he received his Bachelor of Science degree from Union College in Schenectady, New York in 1949. In 1951, he graduated from Rensselaer Polytechnic Institute with a Master of Science in Electrical Engineering, and came to MIT, where he earned his Doctorate of Science and joined the faculty in 1954. He was promoted to Associate Professor in 1958, to Professor in 1962, and to Elihu Thomson Professor in 1973. In 1986, he was conferred the honour of Institute Professor. Professor Haus had a lifelong fascination with noise. While still an undergraduate at Union College, he became aware of Norbert Wiener's theories of statistical phenomena - the new mathematics needed to understand and quantify the random fluctuations we refer to as noise. So it was that noise theory formed the core of Professor Haus' research during the 1950s: noise in electron beams, noise in microwave amplifiers, and noise in amplifier cascades. Two of

  6. [Sensitive character: an almost forgotten personality disorder - illustrated by the case Anton Reiser].

    PubMed

    Tölle, R

    2013-03-01

    n his famous 1918 book „The sensitive relative delusion” Ernst Kretschmer not only described this specific delusional disorder but also the underlying sensitive personality disorder. Until now, relatively little attention has been paid to this part of his work. The incomplete reception is outlined, followed by a description of the symptoms, psychodynamics and course of sensitive personality disorder. The interpretation of "Anton Reiser: a psychological novel" - the autobiographical work by Karl Philipp Moritz in 1785 – is used as an example since it describes Anton Reiser as a sensitive personality.

  7. Anton-Babinski syndrome in an old patient: a case report and literature review.

    PubMed

    Chen, Jiann-Jy; Chang, Hsin-Feng; Hsu, Yung-Chu; Chen, Dem-Lion

    2015-03-01

    Anton-Babinski syndrome is a rare disease featuring bilateral cortical blindness and anosognosia with visual confabulation, but without dementia or any memory impairment. It has a unique neuropsychiatric presentation and should be highly suspected in those with odd visual loss and imaging evidence of occipital lobe injury. In the case discussed herein, a 90-year-old man presented with bilateral blindness, obvious anosognosia, and vivid visual confabulation, which he had had for 3 days. Brain computed tomography demonstrated recent hypodense infarctions at the bilateral occipital lobes. Thus, the patient was diagnosed with Anton-Babinski syndrome. Because of his age and the thrombolytic therapy during the golden 3 hours after ischemic stroke, the patient received aspirin therapy rather than tissue plasminogen activator or warfarin. He gradually realized he was blind during the following week, but died of pneumonia 1 month later. In the literature, it is difficult to establish awareness of blindness in patients with Anton-Babinski syndrome, but optimistically, in one report, a patient was aware of blindness within 2 weeks, without vision improvement. Our case illustrates that elderly patients with Anton-Babinski syndrome can partially recover and that 1 week is the shortest time for the establishment of awareness of blindness for sufferers without vision improvement. © 2014 The Authors. Psychogeriatrics © 2014 Japanese Psychogeriatric Society.

  8. Anton Makarenko: The "John Dewey of the U.S.S.R."

    ERIC Educational Resources Information Center

    Gehring, Thom; Bowers, Fredalene B.; Wright, Randall

    2005-01-01

    There are a few correctional educators whose work is historically so influential that it is difficult to summarize in an article. Anton Makarenko was among this very select group; this is merely an attempt to outline his work. One way to introduce Makarenko to correctional educators is to focus on some of the seemingly incongruous elements of his…

  9. An appreciation of Christiane Groehen: the correspondence between Charles Darwin and Anton Dohrn.

    PubMed

    Browne, Janet

    2015-01-01

    Anton Dohrn was introduced to Darwinism by Ernst Haeckel during his student years at Jena, and became an eager disciple of Charles Darwin's work. He founded the Stazione Zoologica in 1872. Darwin became a patron of Dohrn's Stazione, and the two naturalists corresponded regularly. This article discusses their relationship and the contributions of Christiane Groeben to its elucidation.

  10. Evaluation of the train signal and rail systems for the Anton Anderson Memorial Tunnel.

    DOT National Transportation Integrated Search

    2014-07-01

    The Whittier Access Project was completed in 2000. One phase of the project was to convert the 2.5 mile long Anton Anderson : Memorial Tunnel (Whittier Tunnel) into the worlds only dual-use highway/railroad tunnel with one way reversible highway t...

  11. Seismology at the Australian National University; an interview with Anton L. Hales

    Spall, H.

    1980-01-01

    Dr. Anton L. Hales is a leading seismologist who has just retired as Director of the Research School of Earth Sciences at the Australian National University (ANU), Canberra. Prior to that, he headed the Geosciences Division at the University of Texas at Dallas, and, before that, he was Director of the Bernard Price Institute of Geophysical Research at the University of the Witwatersrand Johannesburg, South Africa. he is about to step down as President of the International Geodynamics Commission. Dr. Hales' research has involved marine geophysics, the travel times of seismic waves, and the structure of the Earth's crust and upper mantle. 

  12. Anton Chekhov and Robert Koch Cheek to Cheek: A Proteomic Study.

    PubMed

    D'Amato, Alfonsina; Zilberstein, Gleb; Zilberstein, Svetlana; Golovan, Mikhail Ivanovich; Zhuravleva, Anastasiya Anatolyevna; Righetti, Pier Giorgio

    2018-05-01

    Five different letters and post cards as well as the shirt worn by Anton Chekhov on his death bed, stored in the State Literary-Memorial Museum-Reserve A. P. Chekhov Melikhovo (nearby Moscow), have been analyzed by applying EVA (an ethyl vinyl acetate foil studded with crushed strong anion and cation exchangers and with C 8 resins) diskettes to these surfaces. Three different eluates (under acidic and basic conditions and with acetonitrile) were analyzed by high resolution mass spectrometry. The environmental microbiota present on samples and the Mycobacterium tuberculosis strain were described by a meta-proteomics approach. Eight identified M. tuberculosis proteins confirmed the presence of the bacterium and the cause of Chekhov's death, in addition to several sequenced peptides belonging to other bacterial species. The human plasma proteins and human keratins, detected on a tiny blood spot on the shirt, demonstrated the power of the combined approach. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Migration, Knowledge Transfer, and the Emergence of Australian Post-War Skiing: The Story of Charles William Anton.

    PubMed

    Strobl, Philipp

    2016-11-01

    Skiing underwent substantial changes during the post-war years when the sport turned into a multi-billion dollar industry and a leisure activity for the masses. Despite its global nature and popularity, skiing in academic writing has not gained much recognition. This paper explores the role of knowledge transfer during the pioneering phase of post-war skiing in Australia. It describes the life of Charles William Anton, an Austrian refugee from the Anschluss who migrated to Sydney and subsequently became one of the founding fathers of Australian post-war skiing. The following pages show the multi-layered nature of skiing as a global sport by exemplifying how ideas spread from pre-war Europe to post-war Australia. The paper will also provide a case study about refugee knowledge transfer and the 'productive process of absorption, adoption or rejection of knowledge' that takes place once an idea has been introduced into a new environment.

  14. Association football and the representation of homosexuality by the print media: a case study of Anton Hysén.

    PubMed

    Cleland, Jamie

    2014-01-01

    In March 2011, Anton Hysén (a semiprofessional footballer currently playing in the Swedish fourth division) became only the second association football (soccer) player of any professional disposition to publicly declare his homosexuality while still playing the game. This article provides a textual analysis of the print media's reaction to Hysén coming out and examines whether, in 2011, they portray more inclusive notions toward homosexuality than they did in 1990 when British footballer Justin Fashanu came out. The results advance inclusive masculinity theory as a number of print media sources (mostly British) interview Hysén in the weeks immediately after he came out and publish articles that challenge homophobia. Highlighting a change since 1990, a significant number of articles stress the need for the key stakeholders in football (players, fans, clubs, agents, the authorities, and the media) to accept gay players.

  15. Migration, Knowledge Transfer, and the Emergence of Australian Post-War Skiing: The Story of Charles William Anton

    PubMed Central

    Strobl, Philipp

    2016-01-01

    Abstract Skiing underwent substantial changes during the post-war years when the sport turned into a multi-billion dollar industry and a leisure activity for the masses. Despite its global nature and popularity, skiing in academic writing has not gained much recognition. This paper explores the role of knowledge transfer during the pioneering phase of post-war skiing in Australia. It describes the life of Charles William Anton, an Austrian refugee from the Anschluss who migrated to Sydney and subsequently became one of the founding fathers of Australian post-war skiing. The following pages show the multi-layered nature of skiing as a global sport by exemplifying how ideas spread from pre-war Europe to post-war Australia. The paper will also provide a case study about refugee knowledge transfer and the ‘productive process of absorption, adoption or rejection of knowledge’ that takes place once an idea has been introduced into a new environment. PMID:29170603

  16. Anton permselective membrane

    NASA Technical Reports Server (NTRS)

    Alexander, S. S.; Hodgdon, R. B.; Waite, W. A.

    1979-01-01

    Experimental composite membranes were synthesized on a lab scale consisting of a thin layer of anion permselective resin supported by and bonded to a porous physically strong and conductive substrate film. These showed good selectivity and also substantially lower electrical resistivities than the homogenous candidate membranes optimized in the previous contract. A wide range of resin porosities were examined for three candidate membrane systems, CDIL, CP4L, and A3L to identify the formulation giving the best overall redox cell performance. Candidate anion membranes showed large increases in resistivity after a short time of immersion in concentrated FeCl/HCl solution. Largely on the basis of resistance stability the CDIL formulation was selected as prime candidate and about thirty-five membranes (one foot square) were produced for experimental static and dynamic evaluation.

  17. [The attempts at drug therapy of cancer by Anton Störck (1731-1803). History of experimental pharmacology in the old Vienna Medical School].

    PubMed

    Schweppe, K W; Probst, C

    1982-03-15

    The essay deals with the development of medical research in Vienna - especially the development of therapeutic drugs. This progress is related to the philosophical, historical, and political background of the enlightened absolutism and the reformatory efforts of van Swieten during the regency of Maria Theresia in Austria. Anton Störck's research on hemlock (Conium maculatum) is used as an example. The method of Störck's research-work is described. Furthermore it is demonstrated to what extent Störck's data, deduced from empirical examinations, are integrated in the official medical system, i.e. Boerhaave's iatromechanic system. Finally the attempt is made to correlate these processes of medical history with the scientific-historical model of Thomas Kuhn.

  18. Benthic Assemblages of the Anton Dohrn Seamount (NE Atlantic): Defining Deep-Sea Biotopes to Support Habitat Mapping and Management Efforts with a Focus on Vulnerable Marine Ecosystems

    PubMed Central

    Davies, Jaime S.; Stewart, Heather A.; Narayanaswamy, Bhavani E.; Jacobs, Colin; Spicer, John; Golding, Neil; Howell, Kerry L.

    2015-01-01

    In 2009 the NW and SE flanks of Anton Dohrn Seamount were surveyed using multibeam echosounder and video ground-truthing to characterise megabenthic biological assemblages (biotopes) and assess those which clearly adhere to the definition of Vulnerable Marine Ecosystems, for use in habitat mapping. A combination of multivariate analysis of still imagery and video ground-truthing defined 13 comprehensive descriptions of biotopes that function as mapping units in an applied context. The data reveals that the NW and SE sides of Anton Dohrn Seamount (ADS) are topographically complex and harbour diverse biological assemblages, some of which agree with current definitions of ‘listed’ habitats of conservation concern. Ten of these biotopes could easily be considered Vulnerable Marine Ecosystems; three coral gardens, four cold-water coral reefs, two xenophyophore communities and one sponge dominated community, with remaining biotopes requiring more detailed assessment. Coral gardens were only found on positive geomorphic features, namely parasitic cones and radial ridges, found both sides of the seamount over a depth of 1311–1740 m. Two cold-water coral reefs (equivalent to summit reef) were mapped on the NW side of the seamount; Lophelia pertusa reef associated with the cliff top mounds at a depth of 747–791 m and Solenosmilia variabilis reef on a radial ridge at a depth of 1318-1351 m. Xenophyophore communities were mapped from both sides of the seamount at a depth of 1099–1770 m and were either associated with geomorphic features or were in close proximity (< 100 m) to them. The sponge dominated community was found on the steep escarpment either side of the seamount over at a depth of 854-1345 m. Multivariate diversity revealed the xenophyophore biotopes to be the least diverse, and a hard substratum biotope characterised by serpulids and the sessile holothurian, Psolus squamatus, as the most diverse. PMID:25992572

  19. Benthic Assemblages of the Anton Dohrn Seamount (NE Atlantic): Defining Deep-Sea Biotopes to Support Habitat Mapping and Management Efforts with a Focus on Vulnerable Marine Ecosystems.

    PubMed

    Davies, Jaime S; Stewart, Heather A; Narayanaswamy, Bhavani E; Jacobs, Colin; Spicer, John; Golding, Neil; Howell, Kerry L

    2015-01-01

    In 2009 the NW and SE flanks of Anton Dohrn Seamount were surveyed using multibeam echosounder and video ground-truthing to characterise megabenthic biological assemblages (biotopes) and assess those which clearly adhere to the definition of Vulnerable Marine Ecosystems, for use in habitat mapping. A combination of multivariate analysis of still imagery and video ground-truthing defined 13 comprehensive descriptions of biotopes that function as mapping units in an applied context. The data reveals that the NW and SE sides of Anton Dohrn Seamount (ADS) are topographically complex and harbour diverse biological assemblages, some of which agree with current definitions of 'listed' habitats of conservation concern. Ten of these biotopes could easily be considered Vulnerable Marine Ecosystems; three coral gardens, four cold-water coral reefs, two xenophyophore communities and one sponge dominated community, with remaining biotopes requiring more detailed assessment. Coral gardens were only found on positive geomorphic features, namely parasitic cones and radial ridges, found both sides of the seamount over a depth of 1311-1740 m. Two cold-water coral reefs (equivalent to summit reef) were mapped on the NW side of the seamount; Lophelia pertusa reef associated with the cliff top mounds at a depth of 747-791 m and Solenosmilia variabilis reef on a radial ridge at a depth of 1318-1351 m. Xenophyophore communities were mapped from both sides of the seamount at a depth of 1099-1770 m and were either associated with geomorphic features or were in close proximity (< 100 m) to them. The sponge dominated community was found on the steep escarpment either side of the seamount over at a depth of 854-1345 m. Multivariate diversity revealed the xenophyophore biotopes to be the least diverse, and a hard substratum biotope characterised by serpulids and the sessile holothurian, Psolus squamatus, as the most diverse.

  20. [The Essen-based steel producer Alfred Krupp (1812-1887) as a reader of the flora and fauna of the Gulf of Naples. A look at the relationship of Anton Dohrn (1840-1909) to the house Krupp].

    PubMed

    Müller, Irmgard

    2015-01-01

    A unfavourable notice written by industrial magnate Alfred Krupp (1812-1887) has been discovered on the posterior cover sheet of the first volume of the monumental series Fauna und Flora des Golfes von Neapel, edited by the Zoological Station at Naples (1880) Krupp's handwritten statement affords the opportunity to discuss in more detail the intricate relationship between the founder of the first marine biology station, Anton Dohrn (1840-1909), and the owner of the greatest steel factory in Europe, the Krupp-family at Essen. Although Anton Dohrn did not know about Krupp's disapproving comment he had a fine unerring instinct for the mentality of his negotiating partner, whose way of thinking rather aimed at the practical success and completion of armament factory, preventing thus a the serious rapprochement between the two personalities. Even when the Krupp-heir, Friedrich Alfred Krupp, later devoted to questions about marine biology in his new built house at Capri, and was willing to support the Zoological Station with high sponsoring, Anton Dohrn maintained a reserved attitude towards the Krupp's offer to support the marine research financially. Likewise, he remained unimpressed, when the steel magnate was shook by the smear campaign in Capri that ultimately led to Krupp's death in November 1902.

  1. Use of OSL dating to establish the stratigraphic framework of Quaternary eolian sediments, Anton scarp upper trench, Northeastern Colorado High Plains, USA

    Mahan, S.A.; Noe, D.C.; McCalpin, J.P.

    2009-01-01

    This paper contains the results of the optically stimulated luminescence (OSL) dating used to establish stratigraphic ages and relationships of eolian sediments in a trench in northeastern Colorado, USA. This trench was located in the upper face of the Anton scarp, a major topographic lineament trending NW-SE for a distance of 135 km, in anticipation of intersecting near-surface faulting. The trench was 180 m long, 4.5-6.0 m deep, and exposed 22 m of stratigraphic section, most of which dipped gently west and was truncated by gulley channeling at the face of the scarp. No direct evidence of faulting was found in the upper trench. The stratigraphy from the trench was described, mapped and dated using OSL on quartz and potassium feldspar, and 14C obtained from woody material. OSL dating identified two upper loess units as Peoria Loess and Gilman Canyon Loess, deposited between 16 and 30 ka ago. The bottom layers of the trench were substantially older, giving OSL ages in excess of 100 ka. These older ages are interpreted as underestimates, owing to saturation of the fast component of OSL. Using OSL and 14C dating, we can constrain the erosion and down cutting of the scarp face as occurring between 16 and 5.7 ka. As the trenching investigation continues in other parts of the scarp face, the results of this preliminary study will be of importance in relating the ages of the strata that underlie different parts of the scarp, and in determining whether Quaternary faulting was a mechanism that contributed to the formation of this regional geomorphic feature.

  2. [The tribute of the pioneer of hypnotherapy--Franz Anton Mesmer, MD, PhD in the history of psychotherapy and medicine].

    PubMed

    Radovancević, Ljubomir

    2009-01-01

    Modern hypnosis started with the Austrian physician Franz Anton Mesmer (1734-1815), who believed that the phenomenon known as mesmerism, or animal magnetism, or fluidum was related to an invisible substance--a fluid that runs within the subject or between the subject and the therapist, that is, the hypnotist, or the "magnetizer". The term hypnosis was introduced in the 1840s by a Scottish surgeon James Braid (1795-1860), who believed the subject to be in a particular state of sleep--a trance. In the late 19th century, a French neurologist Jean Martin Charcot (1825-1893) thought hypnotism to be a special physiological state, and his contemporary Hyppotite-Marie Bernheim (1840-1919) believed it to be a psychological state of heightened suggestibility. Sigmund Freud, who studied with Charcot, used hypnosis early in his career to help patients recover repressed memories. He noted that patients would relive traumatic events while under hypnosis, a process know as abreaction. Freud later replaced hypnosis with the technique of free associations. Today, hypnosis is used as a form of therapy (hypnotherapy), a method of investigation to recover lost memories, and research tool. According to Caplan & Sadock, F.A. Mesmer is generally thought of as the fons et origo of modern psychotherapy; and from the early techniques of mesmerism, it is said, have evolved the more elaborate and sophisticated therapeutic measures of the analyst and his colleagues. Although Mesmer was certainly dealing with individuals suffering from a variety of neurotic disorders, and though the clinical successes he achieved were the result of psychological processes that his procedures induced in his patients, Mesmer's theoretical formulations, his understanding of the nature of the treatment he developed, and his specific procedures were all totally different from those of the 20th century analyst. He was one of the corne stones in the development of psychoanalysis through hypnosis mainly of hysterical

  3. jsc2017e136101 - At the Gagarin Cosmonaut Training Center in Star City, Russia, Expedition 54-55 crewmembers Norishige Kanai of the Japan Aerospace Agency (JAXA, left), Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos, center) and Scott Tin

    2017-12-04

    jsc2017e136101 - At the Gagarin Cosmonaut Training Center in Star City, Russia, Expedition 54-55 crewmembers Norishige Kanai of the Japan Aerospace Agency (JAXA, left), Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos, center) and Scott Tingle of NASA (right) answer reporters’ questions Dec. 4 prior to their departure for their launch site at the Baikonur Cosmodrome in Kazakhstan. They are scheduled to launch Dec. 17 on the Soyuz MS-07 spacecraft for a five-month mission on the International Space Station...Andrey Shelepin/Gagarin Cosmonaut Training Center.

  4. jsc2017e136098 - At the Gagarin Cosmonaut Training Center in Star City, Russia, Expedition 54-55 crewmembers Norishige Kanai of the Japan Aerospace Agency (JAXA, left), Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos, center) and Scott Tin

    2017-12-04

    jsc2017e136098 - At the Gagarin Cosmonaut Training Center in Star City, Russia, Expedition 54-55 crewmembers Norishige Kanai of the Japan Aerospace Agency (JAXA, left), Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos, center) and Scott Tingle of NASA (right) pose for pictures in front of a statue of Vladimir Lenin Dec. 4 prior to their departure for their launch site at the Baikonur Cosmodrome in Kazakhstan. They are scheduled to launch Dec. 17 on the Soyuz MS-07 spacecraft for a five-month mission on the International Space Station...Andrey Shelepin/Gagarin Cosmonaut Training Center.

  5. jsc2017e137344 - At the Cosmonaut Hotel crew quarters in Baikonur, Kazakhstan, Expedition 54-55 prime crewmember Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) tries his hand at a game of billiards Dec. 11 during a break in pre-launch tr

    2017-12-11

    jsc2017e137344 - At the Cosmonaut Hotel crew quarters in Baikonur, Kazakhstan, Expedition 54-55 prime crewmember Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) tries his hand at a game of billiards Dec. 11 during a break in pre-launch training. Shkaplerov, Scott Tingle of NASA and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) will launch Dec. 17 on the Soyuz MS-07 spacecraft from the Baikonur Cosmodrome for a five month mission on the International Space Station...Andrey Shelepin / Gagarin Cosmonaut Training Center.

  6. jsc2017e136052 - At the Gagarin Cosmonaut Training Center in Star City, Russia, Expedition 54-55 prime crewmember Scott Tingle of NASA listens to a reporter’s question during a crew news conference Nov. 30. Tingle, Anton Shkaplerov of the Russian Federa

    2017-11-30

    jsc2017e136052 - At the Gagarin Cosmonaut Training Center in Star City, Russia, Expedition 54-55 prime crewmember Scott Tingle of NASA listens to a reporter’s question during a crew news conference Nov. 30. Tingle, Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos), and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA), will launch Dec. 17 on the Soyuz MS-07 spacecraft from the Baikonur Cosmodrome in Kazakhstan for a five-month mission on the International Space Station...Andrey Shelepin/Gagarin Cosmonaut Training Center..

  7. jsc2017e136097 - At the Gagarin Cosmonaut Training Center in Star City, Russia, Expedition 54-55 crewmember Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) waves to well-wishers Dec. 4 as he boards a bus to depart for nearby Chkalovsky Ai

    2017-12-04

    jsc2017e136097 - At the Gagarin Cosmonaut Training Center in Star City, Russia, Expedition 54-55 crewmember Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) waves to well-wishers Dec. 4 as he boards a bus to depart for nearby Chkalovsky Airfield and a flight to his launch site at the Baikonur Cosmodrome in Kazakhstan. Shkaplerov, Norishige Kanai of the Japan Aerospace Agency (JAXA) and Scott Tingle of NASA will launch Dec. 17 on the Soyuz MS-07 spacecraft for a five-month mission on the International Space Station...Andrey Shelepin/Gagarin Cosmonaut Training Center.

  8. jsc2017e136054 - On a snowy night at Red Square in Moscow, Expedition 54-55 crewmember Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) lays flowers at the Kremlin Wall where Russian space icons are interred in traditional pre-launch cerem

    2017-11-30

    jsc2017e136054 - On a snowy night at Red Square in Moscow, Expedition 54-55 crewmember Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) lays flowers at the Kremlin Wall where Russian space icons are interred in traditional pre-launch ceremonies Nov. 30. Shkaplerov, Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) and Scott Tingle of NASA will launch from the Baikonur Cosmodrome in Kazakhstan on the Soyuz MS-07 spacecraft Dec. 17 for a five-month mission on the International Space Station...Andrey Shelepin/Gagarin Cosmonaut Training Center.

  9. jsc2017e136056 - On a snowy night at Red Square in Moscow, Expedition 54-55 crewmembers Scott Tingle of NASA (left), Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos, center) and Norishige Kanai of the Japan Aerospace Exploration Agency (JA

    2017-11-30

    jsc2017e136056 - On a snowy night at Red Square in Moscow, Expedition 54-55 crewmembers Scott Tingle of NASA (left), Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos, center) and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA, right) pose for pictures at the Kremlin Wall where Russian space icons are interred in traditional pre-launch ceremonies Nov. 30. They will launch from the Baikonur Cosmodrome in Kazakhstan on the Soyuz MS-07 spacecraft Dec. 17 for a five-month mission on the International Space Station...Andrey Shelepin/Gagarin Cosmonaut Training Center.

  10. jsc2017e136059 - On a snowy night at Red Square in Moscow, Expedition 54-55 crewmembers Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos, left), Scott Tingle of NASA (center) and Norishige Kanai of the Japan Aerospace Exploration Agency (JA

    2017-11-30

    jsc2017e136059 - On a snowy night at Red Square in Moscow, Expedition 54-55 crewmembers Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos, left), Scott Tingle of NASA (center) and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA, right) pose for pictures in front of St. Basil’s Cathedral in traditional pre-launch ceremonies Nov. 30. They will launch from the Baikonur Cosmodrome in Kazakhstan on the Soyuz MS-07 spacecraft Dec. 17 for a five-month mission on the International Space Station...Andrey Shelepin/Gagarin Cosmonaut Training Center.

  11. jsc2017e136058 - On a snowy night at Red Square in Moscow, Expedition 54-55 crewmember Scott Tingle of NASA lays flowers at the Kremlin Wall where Russian space icons are interred in traditional pre-launch ceremonies Nov. 30. Tingle, Anton Shkaplerov of t

    2017-11-30

    jsc2017e136058 - On a snowy night at Red Square in Moscow, Expedition 54-55 crewmember Scott Tingle of NASA lays flowers at the Kremlin Wall where Russian space icons are interred in traditional pre-launch ceremonies Nov. 30. Tingle, Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) will launch from the Baikonur Cosmodrome in Kazakhstan on the Soyuz MS-07 spacecraft Dec. 17 for a five-month mission on the International Space Station...Andrey Shelepin/Gagarin Cosmonaut Training Center.

  12. jsc2017e136047 - At the Gagarin Cosmonaut Training Center in Star City, Russia, Expedition 54-55 prime crewmember Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) signs a ceremonial book Nov. 30 as part of traditional pre-launch ceremonies

    2017-11-30

    jsc2017e136047 - At the Gagarin Cosmonaut Training Center in Star City, Russia, Expedition 54-55 prime crewmember Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) signs a ceremonial book Nov. 30 as part of traditional pre-launch ceremonies. In the front row from left to right are the prime crewmembers, Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA), Shkaplerov and Scott Tingle of NASA. Looking on in the back row are the backup crewmembers, NASA’s Jeanette Epps, Sergey Prokopyev of Roscosmos and Alexander Gerst of the European Space Agency. Shkaplerov, Tingle and Kanai will launch Dec. 17 on the Soyuz MS-07 spacecraft from the Baikonur Cosmodrome in Kazakhstan for a five-month mission on the International Space Station...Andrey Shelepin/Gagarin Cosmonaut Training Center.

  13. Fantastic Antone Succeeds! Experiences in Educating Children with Fetal Alcohol Syndrome.

    ERIC Educational Resources Information Center

    Kleinfeld, Judith, Ed.; Wescott, Siobhan, Ed.

    Three themes run through the accounts of parents and teachers as they relate their experiences rearing and teaching children with fetal alcohol syndrome (FAS): (1) Children with FAS can achieve far more than current negative stereotypes suggest; (2) Early intervention and excellent family care make an enormous difference to the success and…

  14. [Did the patients with chronic obstructive pulmonary disease in Primary Care center Anton de Borja correctly utilize inhalers?].

    PubMed

    Represas-Carrera, Francisco Jesús

    2015-01-01

    To determine the percentage of patients with Pulmonary Obstructive Chronic Disease who doing of incorrect form the inhaler technique. Descriptive transversal study made in the Primary Care Center "Antón de Borja" of Rubi (in Barcelona) during the period between May and December 2013, where it was studied a representative sample of 200 patients. To assess the inhaler technique was performed a personal interview with the patient in which it was requested him to carry out a demonstration of how he was using his inhaler regularly evaluating his inhaler technique by means of the regulations established by Spanish Society of Pneumology and Thoracic Surgery. 43% of the patients carry out inhaler technique incorrectly. The percentage of inadequate use of inhalers of dry powder was 26%, of the pressurized cartridge 38% and the inhaler chamber 10%. 82% of patients ≥ 65 years who have prescribed a pressurized inhaler cartridge do not perform accompanied by an inhaler chamber. A high percentage of patients do not correctly carry out inhaler technique, pointing the rare use made of the inhaler chamber despite its proven efficacy and the high number of patients with pressurized inhaler cartridge. These results reflect the need for the implementation of an educational program in our Primary Care Center to teach patients to use inhaler devices. Copyright © 2014 Elsevier España, S.L.U. All rights reserved.

  15. [IPA secretary and patron--Freud's patient, financial administrator and friend. Anton von Freund's letters to Sigmund Freud (1916-1919)].

    PubMed

    Huppke, Andrea; Schröter, Michael

    2011-01-01

    Although the letters, of which numerous and lengthy excerpts are presented in this paper, have repeatedly been used by scholars, they have so far remained unpublished. There are 45 items, written between 4. 1. 1916 and 13. 7. 1919. They indicate a passionate transference to Freud, unfolding against the background of two Hungarian revolutions. After suffering a relapse of his cancer, v. Freund had several stretches of analysis with Freud. While he was better, he established two major funds: one of them allowing the foundation of the psychoanalytic publishing house, the other destined to sponsor a psychoanalytic clinic in Budapest. V. Freund helped organize the Budapest IPA congress, became a member of the "secret committee" and started to actively conduct analyses. Freud was very attached to him and felt deeply shaken by the inexorable progression of v. Freund's disease and then death in January 1920.

  16. The Hybrid Expert in the "Bergstaat": Anton Von Ruprecht as a Professor of Chemistry and Mining and as a Mining Official, 1779-1814

    ERIC Educational Resources Information Center

    Konecny, Peter

    2012-01-01

    In the course of the 18th century a new type of scientifically educated functional elites developed, who were trained to administer mines. The educational project that led to the formation of a corps of mining engineers was part of a programme of administrative and economic reforms that led to a new configuration of bonds between state, economy…

  17. Commission 20: Position and Motion of Minor Planets, Comets and Satellites

    NASA Astrophysics Data System (ADS)

    Valsecchi, Giovanni B.; Fernandez, Julio; Bowell, Edward L. G.; Arlot, Jean-Eudes; Bowell, Edward L. G.; Chernetenko, Yulia A.; Chesley, Steven R.; Lazzaro, Daniela; Lemaitre, Anne; Marsden, Brian G.; Muinonen, Karri; Rickman, Hans; Tholen, David J.; Yoshikawa, Makoto

    2007-12-01

    A total of 16 among the new IAU members have asked to join Commission 20; they are: Jerome Berthier, Nicholas J. Cooper, Marco Delbò, Romina P. Di Sisto, Michael W. Evans, Tetsuharu Fuse, Ludmila Hudkova, Yurij N. Krugly, Elena N. Polyakhova, Zhanna Pozhalova, Alessandro Rossi, Qi Rui, Jonathan D. Shanklin, Slawomira E. Szutowicz, Gino Tuccari and Hong-Suh Yim. Moreover, two requests to join the Commission have been received by astronomers that are already IAU members: Peter De Cat and Ricardo A. Gil-Hutton.

  18. Regional Seismograms: Attenuation and Scattering

    DTIC Science & Technology

    1992-03-06

    Ningya Cheng Anton M. Dainty Batakrishna Mandal Chengbin Peng Craig A. Schultz Earth Rc3ources Laboratory Department of Earth, Atmospheric, and Planetary...Institute of Technology Anton M. Dainty, Founding Member Fellow, Massachusetts Institute of Technology Batakrishna Mandal, Research Scientist, Massachusetts...particular I would like to thank Chris "dude" Bradley, Richard Coates, Vern Cormier, Anton Dainty, Joe Matarese, Jeff Meredith, Mike Prange, Bill

  19. Carbon Nanotube Based Flexible Supercapacitors

    DTIC Science & Technology

    2011-04-01

    Carbon Nanotube Based Flexible Supercapacitors by Christopher M. Anton and Matthew H. Ervin ARL-TR-5522 April 2011...Carbon Nanotube Based Flexible Supercapacitors Christopher M. Anton and Matthew H. Ervin Sensors and Electron Devices Directorate, ARL...September 2010 4. TITLE AND SUBTITLE Carbon Nanotube Based Flexible Supercapacitors 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT

  20. Shkaplerov makes a selection from food container

    2012-02-03

    ISS030-E-117514 (3 Feb. 2012) --- Russian cosmonaut Anton Shkaplerov, Expedition 30 flight engineer, makes a selection from a food storage container in the Zvezda Service Module of the International Space Station.

  1. ISS Expedition 42 Crew Profiles - Version 01

    2014-11-14

    Narrated program with biographical information about ISS Expedition 42 crewmembers Terry Virts, Samantha Cristoforetti and Anton Shjaplerov. The program covers the crewmember's career including childhood photographs; footage from previous missions; and interview sound bites.

  2. 78 FR 1210 - Notice of Membership of Performance Review Board for Senior Executives (PRB)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ...., Section 4314(c)(4). The Commission's PRB will remove the following member: Charles H. Schneider The Commission's PRB will add the following member: Anton C. Porter, PRB Chairman Dated: January 2, 2013...

  3. 78 FR 10692 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-14

    ... ROBERT DANIEL HESS JOCELYN CAMPOS HIGHFIELD TUCKER M JONSSON N STEPHAN W LEUNG JANICE T L LEVY-LANG... SCHMITH SCOTT CHARLES SHOLSETH THOMAS JOSEPH SIGG ALFRED STEWART HOLLY DAWN STUDER ANTON ALOIS VAN...

  4. Shkaplerov exercises on the aRED

    2012-01-05

    ISS030-E-235507 (5 Jan. 2012) --- Russian cosmonaut Anton Shkaplerov, Expedition 30 flight engineer, exercises using the advanced Resistive Exercise Device (aRED) in the Tranquility node of the International Space Station.

  5. The Future of Officer Career Development System in the Slovenian Armed Forces

    DTIC Science & Technology

    2013-12-13

    Professors Anton Zabkar and Uros Svete, at the Faculty for Social Science at University of Ljubljana, clearly identified the deficiencies in the...short-lived solution], Slovenian Armed Forces Bulletin 10, no. 1 (May 2008): 97-120. 5Anton Zabkar and Uros Svete, “Solanje Vojaskih Profesionalcev...is based on Length of Service ( LoS ) and applies to all DE officers and the other is the LE career structure.87 85Major Al Thorp, e-mail message to

  6. Investigating the Acquisition of Software Systems that Rely on Open Architecture and Open Source Software

    DTIC Science & Technology

    2010-03-01

    associated with certain software systems [Breaux and Anton 2008]. With this basis to build on, it is now possible to analyze the alignment of...Kazman, R., (2003). Software Architecture in Practice, 2nd Edition, Addison-Wesley Pro- fessional, New York.. Breaux, T.D. and Anton , A.I. (2008... calculus for license rights and obligations in license and context models. Using them, we calculate rights and obligations for specific sys- tems, identify

  7. Reprisal Under International Law: A Defense to Criminal Conduct?

    DTIC Science & Technology

    2009-03-25

    that authority in denying a reprisal defense. In the trial of General Anton Dostler in October 1945, the Commission reaffirmed there could be no...experience. This causal proximity may be part of the calculus that supports a soldier’s 15 decision to reprise, and the soldier must know his decision...and Accountability Under International Law, 131. 26 Ibid., 133. 27 Trial of General Anton Dostler, United States Military Commission, Rome, 8-12

  8. A Probe for Measuring Spacecraft Surface Potentials Using a Direct-Gate Field Effect Transistor.

    DTIC Science & Technology

    1983-09-30

    SURFACE POTENTIALS USING A DIRECT-GATE FIELD EFFECT TRANSISTOR Mark N. Horenstein Anton Havretic Trustees of Boston University 881 Commonwealth Avenue...1933 Transistor 6. PERFORMING ORG. REPORT NUMBER 7. AUTHOR(s) S. CONTRACT OR GRANT NUMBER(&) ’_5 Mark N. Horenstein Anton Mavretic F19628-82-K-00 34...at AFGL. These tests can be considered the bench mark tests for device performance, with all elements of the monitoring system optimized to eliminate

  9. Further Results on the Disturbance Response of a Double Integrator Controlled by Saturating Linear Static State Feedback

    DTIC Science & Technology

    2011-07-13

    Anton A. Stoorvogel b, Håvard Fjær Grip a aSchool of Electrical Engineering and Computer Science, Washington State University, Pullman, WA 99164-2752...utwente.nl ( Anton A. Stoorvogel), grip@ieee.org (Håvard Fjær Grip). of a double integrator controlled by a saturating linear static state feedback...References Chitour, Y., 2001. On the Lp stabilization of the double integrator subject to input saturation. ESAIM: Control, Optimization and Calculus

  10. Landmarks in the Literature: Super Soviet Pedagogue.

    ERIC Educational Resources Information Center

    Alston, Patrick L.

    1979-01-01

    Anton Makarenko became a national hero for effecting education for communism in the 1920s. His book, "The Road to Life," is an artistic achievement and the most widely read and influential work on education in the Soviet Union. But Makarenko's legacy is more myth than model in present-day Russia. (Author/SJL)

  11. Expedition 54-55 Crew Launches to the Space Station

    2017-12-17

    Expedition 54-55 Soyuz Commander Anton Shkaplerov of Roscosmos and Flight Engineers Scott Tingle of NASA and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) launched to space on the Russian Soyuz MS-07 spacecraft on Dec. 17 from the Baikonur Cosmodrome in Kazakhstan.

  12. Weight Measurements and Standards for Military Personnel

    DTIC Science & Technology

    2008-09-01

    Food Photography Method (RFPM) for use in free-living conditions. When using the RFPM, participants take photographs of their food selection and...children. Obesity, 15, 906-917, 2007. 6. Martin, C., Han, H., Coulon, S., Allen, H., & Anton, S. (2008). The Remote Food Photography Method: An

  13. Shkaplerov makes a selection from food container

    2012-02-03

    ISS030-E-117515 (3 Feb. 2012) --- Russian cosmonaut Anton Shkaplerov, Expedition 30 flight engineer, makes a selection from a food storage container in the Zvezda Service Module of the International Space Station. NASA astronaut Dan Burbank, commander, is visible in the background.

  14. ISS Expedition 42 Crew Profile, Version 2

    2014-11-26

    Narrated production with biographical information about ISS Expedition 42 crewmembers Barry "Butch" Wilmore, Alexander Samokutyaev, Elena Serova, Terry Virts, Anton Shkaplerov and Samantha Cristoforetti. The program covers the crewmember's career including childhood photographs, previous space missions and interview sound bites with the crewmembers.

  15. The College Adjustment Questionnaire: A Measure of Students' Educational, Relational, and Psychological Adjustment to the College Environment

    ERIC Educational Resources Information Center

    O'Donnell, Maeve B.; Shirley, Lauren A.; Park, Stacey S.; Nolen, Julian P.; Gibbons, Alyssa M.; Rosén, Lee A.

    2018-01-01

    Several instruments exist to measure college adjustment: the Student Adaptation to College Questionnaire (SACQ; Baker & Siryk, 1989), the College Adjustment Rating Scale (Zitzow, 1984), and the College Adjustment Scales (Anton & Reed, 1991). Of these, the SACQ is the most widely used and takes a multifaceted approach to measuring college…

  16. Reconstructing Operational Theory: A Framework for Emerging Threats in a Complex Environment

    DTIC Science & Technology

    2007-01-01

    General Shimon Naveh. While the composition and construction of the urban environment traditionally influence targeting calculus , this is not the same as... Anton . "The Relevance of Chaos Theory to Operations." Australian Defense Force Journal. No. 162. Sep/Oct 2003, 4-18. Lind, William

  17. Extending the Phase Zero Campaign Mindset

    DTIC Science & Technology

    2007-01-01

    activities would automatically take U.S. forces out of the fight in current operations. Instead, it would improve the calculus of the Government’s...ndu.edu Liaison officer  for U.S. State  Department  training Iraqi  police Fleet Combat Camera, Pacific (Martin Anton Edgil) Extending the Phase

  18. A Comprehensive Officer Sabbatical Program: Rethinking the Military Officer Career Path

    DTIC Science & Technology

    2009-04-09

    attractive in the civilian world. However, retaining junior officers is more than just a calculus based upon raw numbers. The Army needs to keep...personal knowledge obtained on Anton Myrer Army Leader Day at U.S. Army War College on October 15, 2008 during discussions with Army Senior Leadership

  19. Africom’s Dilemma: The Global War on Terrorism, Capacity Building, Humanitarianism, and the Future of U.S. Security Policy in Africa

    DTIC Science & Technology

    2007-11-01

    insurgencies are ameliorated through a radical new calculus of effort: 80 percent political, diplomatic, developmental, and informational; and 20...to Hunt al-Qaeda in Africa,” p. A1. 69 167. Anton Menning, “CJTF HOA: Long Term Solutions to Combating Terrorism,” The Leavenworth Times, August

  20. Shkaplerov participates in a CHeCS Medical Contingency Drill in the U.S. Laboratory

    2011-12-16

    ISS030-E-012600 (16 Dec. 2011) --- Russian cosmonaut Anton Shkaplerov, Expedition 30 flight engineer, participates in a Crew Health Care System (CHeCS) medical contingency drill in the Destiny laboratory of the International Space Station. This drill gives crew members the opportunity to work as a team in resolving a simulated medical emergency onboard the space station.

  1. Ivanishin participates in a CHeCS Medical Contingency Drill in the U.S. Laboratory

    2011-12-16

    ISS030-E-012604 (16 Dec. 2011) --- Russian cosmonauts Anatoly Ivanishin (foreground) and Anton Shkaplerov, both Expedition 30 flight engineers, participate in a Crew Health Care System (CHeCS) medical contingency drill in the Destiny laboratory of the International Space Station. This drill gives crew members the opportunity to work as a team in resolving a simulated medical emergency onboard the space station.

  2. 17. 'BIRDSEYEVIEW, PRESIDIO OF MONTEREY, CAL., JAN. 1938.' No signature, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. 'BIRDSEYEVIEW, PRESIDIO OF MONTEREY, CAL., JAN. 1938.' No signature, photographer probably Anton C. Heidrick. This panoramic view looks west over Soldier Field from the upper floor or roof of the gymnasium. Original cool toned silver gelatin print measures 85.1 cm by 22.4 cm, flush mounted on mat board. - Presidio of Monterey, Soldier Field, Monterey, Monterey County, CA

  3. Integrative Education: Teaching Psychology with the Use of Literature and Informational Technology

    ERIC Educational Resources Information Center

    Toom, Anna

    2013-01-01

    In this work, a new method of teaching psychology based on the union of scientific, artistic, and information-technological knowledge is presented. The author teaches Cognitive Development in Early Childhood analyzing Anton Chekhov's short story "Grisha" and uses both traditional and computerized instructional methodology. In the authors' two…

  4. Ice cream

    2015-04-20

    ISS043E125774 (04/20/2015) --- NASA astronaut Scott Kelly gives the "high sign" on the quality of his snack while taking a break from his work schedule aboard the International Space Station on Apr. 20, 2015. Russian cosmonaut Anton Shkaplerov (ROSCOSMOS) seems to agree on the tasty factor of the specially prepared space food.

  5. The Way of the Drum: When Earth Becomes Heart.

    ERIC Educational Resources Information Center

    Antone, Grafton; Turchetti, Lois Provost

    Two Native people describe their respective journeys to healing, journeys that involved the rediscovery of language and culture. In Part I, "Healing the Tears of Yesterday by the Drum Today: The Oneida Language Is a Healing Medicine" (Grafton Antone), the first narrator taught the Oneida language to adult students at a community center.…

  6. Adaptive Identification by Systolic Arrays.

    DTIC Science & Technology

    1987-12-01

    BIBLIOGRIAPHY Anton , Howard, Elementary Linear Algebra , John Wiley & Sons, 19S4. Cristi, Roberto, A Parallel Structure Jor Adaptive Pole Placement...10 11. SYSTEM IDENTIFICATION M*YETHODS ....................... 12 A. LINEAR SYSTEM MODELING ......................... 12 B. SOLUTION OF SYSTEMS OF... LINEAR EQUATIONS ......... 13 C. QR DECOMPOSITION ................................ 14 D. RECURSIVE LEAST SQUARES ......................... 16 E. BLOCK

  7. Biological Basis for Chemoprevention of Ovarian Cancer. Addendum

    DTIC Science & Technology

    2007-10-01

    Campbell I, Chang-Claude J, Peel D, Anton-Culver H, Berchuck A, Schildkraut J, Whittemore A, McGuire V, DiCioccio RA, Duffy D, Chenevix-Trench G...promotor polymorphism and ovarian cancer risk. Int J Cancer 2000;86:436–9. 23. Menin C, Banna GL, De Salvo G, et al. Lack of association between

  8. Biological Basis for Chemoprevention of Ovarian Cancer

    DTIC Science & Technology

    2006-10-01

    2005;16:955-63. 11) Kelemen L, James M, Spurdle A, Campbell I, Chang-Claude J, Peel D, Anton-Culver H, Berchuck A, Schildkraut J, Whittemore A...X., Abbazadegan, M., et al. CYP17 promotor polymorphism and ovarian cancer risk. Intl J Cancer. 2000; 86: 436-9. 23.Menin, C., Banna , G. L., De

  9. The Miami Linguistic Reading Program, 1965-1968. Report.

    ERIC Educational Resources Information Center

    Digneo, Ellen Hartnett, Ed.; Shaya, Tila, Ed.

    Information related to the implementation of the Miami Linguistic Reading Program for Spanish-speaking and American Indian children in 6 New Mexico school systems is presented. School systems utilizing and reporting on the program are: (1) the West Las Vegas School System; (2) Anton Chico Elementary School in Santa Rosa; (3) Pojoaque Valley…

  10. Birthday party

    2015-04-26

    ISS043E142528 (04/26/2015) ---From the International Space Station NASA astronaut Terry Virts (right) tweeted this image of he and his crewmate Russian cosmonaut Anton Shkaplerov celebrating the birthday of ESA (European Space Agency) astronaut Samantha Cristoforetti (middle). His tweet commented: "Happy Birthday @AstroSamantha! We had a great time celebrating as a crew."

  11. Effectiveness of Graduate Training in School Psychology: Perspectives of Graduate Practitioners

    ERIC Educational Resources Information Center

    Satchwell, Mary Susan

    2013-01-01

    While trends in graduate training in school psychology indicate a movement towards an increasing emphasis on consultation and decreasing emphasis on assessment (Anton-LaHart & Rosenfield, 2004), there remains a gap between training and practice for professional school psychologists (Harrison, et al., 2004). The present study provided an…

  12. ISS Expedition 42 / 43 Soyuz Spacecraft and Crew Preparations for Launch

    2014-11-26

    NASA TV (NTV) video file of crewmembers Terry Virts, Anton Shkaplerov (Roskosmos) and Samantha Cristoforetti (ESA) during final fit check of the Soyuz TMA 15M spacedraft at the Integration Facility, Baikonurk, Kazakhstan. Includes footage of the crew climbing into the Soyuz spacecraft, interviews, visit to museum where the crew sign posters and a flag; flag raising ceremony; and visit to mating facility.

  13. York Papers in Linguistics 14.

    ERIC Educational Resources Information Center

    Harlow, S. J., Ed.; Warner, A. R., Ed.

    Papers on a variety of linguistic topics include six papers from a Festschrift and nine others, as follows: "Attitudes Towards English as a Possible Lingua Franca in Switzerland" (Urs Durmuller); "Functional Stability and Structural Levelling of Dialects: The Case of Maastricht" (Anton M. Hagen, Henk Munstermann); "On the…

  14. Burbank trims Shkaplero's hair in the Node 3

    2011-12-18

    ISS030-E-012660 (18 Dec. 2011) --- NASA astronaut Dan Burbank, Expedition 30 commander, trims the hair of Russian cosmonaut Anton Shkaplerov, flight engineer, in the Tranquility node of the International Space Station. Burbank used hair clippers fashioned with a vacuum device to garner freshly cut hair.

  15. Burbank trims Shkaplerov's hair in the Node 3

    2012-03-18

    ISS030-E-161707 (18 March 2012) --- NASA astronaut Dan Burbank, Expedition 30 commander, trims the hair of Russian cosmonaut Anton Shkaplerov, flight engineer, in the Tranquility node of the International Space Station. Burbank used hair clippers fashioned with a vacuum device to garner freshly cut hair.

  16. Shkaplerov trims Burbank's hair in the Node 3

    2011-12-18

    ISS030-E-012655 (18 Dec. 2011) --- Russian cosmonaut Anton Shkaplerov, Expedition 30 flight engineer, trims the hair of NASA astronaut Dan Burbank, commander, in the Tranquility node of the International Space Station. Shkaplerov used hair clippers fashioned with a vacuum device to garner freshly cut hair.

  17. NATO Enlargement and Democratic Control of the Armed Forces: The Experience of Poland and Implications for Neighboring "Partnership for Peace" Countries.

    DTIC Science & Technology

    1998-03-01

    borders. You do not follow our suggestions, and we feel threatened...we are 88 See Hannah Arendt , "Reflections on the Hungarian Revolution," Journal of...Press, 1977). Arendt , Hanna, "Reflections on the Hungarian Revolution," Journal of Politics 20.1 (February 1958). Bebler, Anton A., "Postscript" in

  18. Russian State Commission Meeting and Final ISS Expedition 54-55 Crew News Conference

    2017-12-16

    In preparation for launch, the final meeting between the Russian State Commission and the crew of International Space Station Expedition 54-55 meets in Baikonur, Kazakhstan. Prime crew members are Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA), Anton Shkaplerov the Russian Federal Space Agency (Roscosmos) and Scott Tingle of NASA.

  19. Ocean Engineering Studies Compiled 1991. Volume 10. External Pressure Housing - Concrete

    DTIC Science & Technology

    1991-01-01

    Hafsklold Ing. F. Selmer AS Anton Brandtzaeg Post Office Box 256 Professor of Construction & Harbour Oslo, Norway Engineering Norwegian Technical University...1984, pp 364-411. 50. 0. Olsen , "Implosion analysis of concrete cylinders under hydro- static pressure," ACI, vol 75, no. 3, Mar 1973, pp 82-85. 51. K.P

  20. iss042e306480

    2015-03-07

    ISS042E306480 (03/07/2015) --- A meeting of the minds aboard the International Space Station on Mar. 7, 2015 with members of Expedition 42; astronauts US, Barry Wilmore (Commander) Top, Upside down, to the right cosmonaut Elena Serova, & ESA European Space Agency Samantha Cristoforetti. Bottom center US astronaut Terry Virts, top left cosmonauts Alexander Samokutyaev and Anton Shkaplerov.

  1. The Democratic School and the Pedagogy of Janusz Korczak: A Model of Early Twentieth Century Reform in Modern Israel

    ERIC Educational Resources Information Center

    Engel, Liba H.

    2013-01-01

    This article explores the history and pedagogy of Janusz Korczak within the context of his contemporary early Twentieth-Century European Innovative Educators which include Maria Montessori, Homer Lane, A.S. Neill, and Anton Semyonovitch Makarenko. The pedagogies of the aforementioned are compared and contrasted within the literature.

  2. Burbank and Shkaplerov playing musical instruments

    2012-04-21

    ISS030-E-267658 (21 April 2012) --- NASA astronaut Dan Burbank, Expedition 30 commander, plays a guitar, while Russian cosmonaut Anton Shkaplerov, flight engineer, plays a musical keyboard during off-time in the Unity node of the International Space Station.

  3. Burbank and Shkaplerov with musical instruments

    2012-04-21

    ISS030-E-267652 (21 April 2012) --- NASA astronaut Dan Burbank (with guitar), Expedition 30 commander, and Russian cosmonaut Anton Shkaplerov, flight engineer, are pictured at a musical keyboard during off-time in the Unity node of the International Space Station.

  4. Burbank and Shkaplerov playing musical instruments

    2012-04-21

    ISS030-E-267651 (21 April 2012) --- NASA astronaut Dan Burbank, Expedition 30 commander, plays a guitar, while Russian cosmonaut Anton Shkaplerov, flight engineer, plays a musical keyboard during off-time in the Unity node of the International Space Station.

  5. Robotics Competitions and Science Classrooms

    ERIC Educational Resources Information Center

    Benke, Gertraud

    2012-01-01

    This paper looks at the distinctions between science classrooms and the robotics competition described in the article "Examining the mediation of power in a collaborative community: engaging in informal science as authentic practice" written by Anton Puvirajah, Geeta Verma and Horace Webb. Using the framework of "productive disciplinary…

  6. Franklin, Lavoisier, and Mesmer: origin of the controlled clinical trial.

    PubMed

    Herr, Harry W

    2005-01-01

    In 1784, a Royal Commission headed by Benjamin Franklin and Antoine Lavoisier designed a series of ingenious experiments to debunk France's greatest medical rogue, Anton Mesmer, and his bizarre healing of illnesses based on his bogus theory of animal magnetism. Using intentional subject ignorance and sham interventions to investigate mesmerism, Franklin's commission provided a model for the controlled clinical trial.

  7. Shkaplerov works with EVA Hardware in the SM

    2012-02-03

    ISS030-E-061157 (3 Feb. 2012) --- Russian cosmonaut Anton Shkaplerov, Expedition 30 flight engineer, works with extravehicular activity (EVA) hardware in the Zvezda Service Module of the International Space Station in preparation for an EVA scheduled for Feb. 16, 2012.

  8. State of the Modern Information Professional, 1992-1993. An International View of the State of the Information Professional and the Information Profession in 1992-1993. FID Occasional Paper 4.

    ERIC Educational Resources Information Center

    International Federation for Information and Documentation, The Hague (Netherlands).

    The following 14 papers are provided: (1) "Perfil del profesional de la informacion en Venezuela" with a synopsis in English: "Profile of the Information Professional in Venezuela" (A. D. Anton and M. S. de Arenas); (2) "The Modern Information Professional in the Caribbean Setting" (D. Douglas); (3) "Development…

  9. Teaching Translation and Interpreting in Slovakia: Is There Anything Other than Levý and Popovic?

    ERIC Educational Resources Information Center

    Biloveský, Vladimír; Djovcoš, Martin

    2016-01-01

    Institutional translation and interpreting training has a long lasting tradition in Slovakia mainly thanks to such significant translation scholars as Anton Popovic, František Miko, Ján Vilikovský and many others. However the situation has changed after the Velvet Revolution in 1989 and the education needed to start adapting to the new market…

  10. ISS Expedition 54-55 Docking, Hatch Opening and Welcome Activities

    2017-12-19

    After launching Dec. 17 in their Soyuz MS-07 spacecraft from the Baikonur Cosmodrome in Kazakhstan, Expedition 54-55 Soyuz Commander Anton Shkaplerov of Roscosmos and Flight Engineers Scott Tingle of NASA and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) arrived at the International Space Station Dec. 19 to complete a two-day journey, docking their vehicle to the Rassvet module on the Russian segment of the complex. A few hours after docking their Soyuz MS-07 spacecraft to the International Space Station, Expedition 54-55 Soyuz Commander Anton Shkaplerov of Roscosmos and Flight Engineers Scott Tingle of NASA and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA), opened hatches and were greeted by station Commander Alexander Misurkin of Roscosmos and Flight Engineers Joe Acaba and Mark Vande Hei of NASA.

  11. jsc2011e203164

    2011-10-23

    At the Kremlin Wall in Moscow, Expedition 30 Commander Dan Burbank of NASA laid flowers October 24, 2011 in a traditional ceremony during the tour of Red Square he and his crewmates conducted prior to their launch to the International Space Station November 14 on the Soyuz TMA-22 spacecraft from the Baikonur Cosmodrome in Kazakhstan. Burbank, Soyuz Commander Anton Shkaplerov and Anatoly Ivanishin will arrive in Baikonur October 31 for final pre-launch preparations. Credit: NASA

  12. Next Space Station Crew Prepares for Mission

    2017-12-01

    B-roll footage includes various pre-launch training activities of Expedition 54-55, featuring Soyuz Commander Anton Shkaplerov of Roscosmos and Flight Engineers Scott Tingle of NASA and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA), as they prepare for their mission to the International Space Station. The trio will launch to the station aboard a Soyuz spacecraft on Dec. 17 from the Baikonur Cosmodrome in Kazakhstan.

  13. Weight Measurements and Standards for Soldiers

    DTIC Science & Technology

    2009-10-01

    Dr. Corby Martin has expanded on this technology and has developed the Remote Food Photography Method (RFPM) for use in free-living conditions...Allen HR, Champagne CM, Anton SD. A novel method to remotely measure food intake of free-living individuals in real time: the remote food ... photography method. Br J Nutr. 2009 Feb;101:446-56. 5. Martin CK, Kaya S, Gunturk BK. Quantification of food intake using food image analysis. Conference

  14. Complete Genome Sequence of NEB 5-alpha, a Derivative of Escherichia coli K-12 DH5α.

    PubMed

    Anton, Brian P; Raleigh, Elisabeth A

    2016-11-10

    Escherichia coli K-12 DH5α is one of the most popular and widely available laboratory strains, but, surprisingly, no complete genome sequence has been publicly available. Here, we report the complete, finished sequence of NEB 5-alpha (DH5α fhuA2). It should serve as a useful reference for researchers working with DH5α. Copyright © 2016 Anton and Raleigh.

  15. Burbank participates in a CHeCS Medical Contingency Drill in the U.S. Laboratory

    2011-12-16

    ISS030-E-012613 (16 Dec. 2011) --- NASA astronaut Dan Burbank (foreground), Expedition 30 commander, and Russian cosmonaut Anton Shkaplerov, flight engineer, participate in a Crew Health Care System (CHeCS) medical contingency drill in the Destiny laboratory of the International Space Station. This drill gives crew members the opportunity to work as a team in resolving a simulated medical emergency onboard the space station.

  16. Burbank participates in a CHeCS Medical Contingency Drill in the U.S. Laboratory

    2011-12-16

    ISS030-E-012609 (16 Dec. 2011) --- NASA astronaut Dan Burbank (foreground), Expedition 30 commander, and Russian cosmonaut Anton Shkaplerov, flight engineer, participate in a Crew Health Care System (CHeCS) medical contingency drill in the Destiny laboratory of the International Space Station. This drill gives crew members the opportunity to work as a team in resolving a simulated medical emergency onboard the space station.

  17. 14. 'TROOP A, OREGON CAVALRY IN CAMP AT PRESIDIO OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. 'TROOP A, OREGON CAVALRY IN CAMP AT PRESIDIO OF MONTEREY, CALIFORNIA, 1915.' Anton C. Heidrick, photographer. This panoramic view looks west from the lower end of Soldier Field, before construction of walls and roads. Original warm toned silver gelatin print measures 94.9 cm by 19.7 cm, flush mounted on mat board. - Presidio of Monterey, Soldier Field, Monterey, Monterey County, CA

  18. 16. 'EXCELLENT NEW PARADE GROUND BEST SINCE POST ESTABLISHED. STARTED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. 'EXCELLENT NEW PARADE GROUND BEST SINCE POST ESTABLISHED. STARTED BY COL. RALPH PARKER, FINISHED BY COL. TROUPE MILLER, PRESIDIO OF MONTEREY CALIFORNIA.' No date, probably ca. 1936. No signature, photographer probably Anton C. Heidrick. This panoramic view looks east over Soldier Field to the Bay, from the cannons at the west end. Original hand tinted silver gelatin print measures 90.4 cm by 20.2 cm, flush mounted on mat board. - Presidio of Monterey, Soldier Field, Monterey, Monterey County, CA

  19. Expedition 54 Press Conference

    2017-12-16

    Expedition 54 backup crew member Sergey Prokopev is seen in quarantine, behind glass, during a press conference, Saturday, Dec. 16, 2017 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Expedition 54 prime crew members Soyuz Commander Anton Shkaplerov of Roscosmos, flight engineer Scott Tingle of NASA, and flight engineer Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) are scheduled to launch to the International Space Station aboard the Soyuz spacecraft from the Baikonur Cosmodrome on December 17. Photo Credit: (NASA/Joel Kowsky)

  20. Expedition 54 Press Conference

    2017-12-16

    Expedition 54 flight engineer Scott Tingle is seen in quarantine, behind glass, during a press conference, Saturday, Dec. 16, 2017 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Tingle, Soyuz Commander Anton Shkaplerov of Roscosmos, and flight engineer Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) are scheduled to launch to the International Space Station aboard the Soyuz spacecraft from the Baikonur Cosmodrome on December 17. Photo Credit: (NASA/Joel Kowsky)

  1. Expedition 54 Press Conference

    2017-12-16

    Expedition 54 Soyuz Commander Anton Shkaplerov of Roscosmos is seen in quarantine, behind glass, during a press conference, Saturday, Dec. 16, 2017 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Shkaplerov, flight engineer Scott Tingle of NASA, and flight engineer Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) are scheduled to launch to the International Space Station aboard the Soyuz spacecraft from the Baikonur Cosmodrome on December 17. Photo Credit: (NASA/Joel Kowsky)

  2. Expedition 54 Press Conference

    2017-12-16

    Expedition 54 prime crew members flight engineer Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA), left, Soyuz Commander Anton Shkaplerov of Roscosmos, center, and flight engineer Scott Tingle of NASA, left, are seen in quarantine, behind glass, during a press conference, Saturday, Dec. 16, 2017 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Kanai, Shkaplerov, and Tingle are scheduled to launch to the International Space Station aboard the Soyuz spacecraft from the Baikonur Cosmodrome on December 17. Photo Credit: (NASA/Joel Kowsky)

  3. ISS Expedition 42 / 43 Crew Training Resource Reel (JSC-2641)

    2014-11-14

    Media resource reel of ISS Expedition 42 / 43 Crew training activities. Includes footage of crew photo shots with Samantha Cristoforetti, Anton Shkaplerov and Terry Virts; Routine shots with Virts, ISS Expedition 43 crewmember Scott Kelly, Cristoforetti, ISS Expedition 41 / 42 crewmember Barry Wilmore; and Shklaplerov; T-38 Operations with Virts; Routine operations with Cristoforetti, Shkaplerov and Virts; Neutral Buoyancy Lab (NBL) with Cristoforetti and Kelly; and Emergency Scenatios with Virts, Cristoforetti and Shkaplerov.

  4. E-Pals: Examining a Cross-Cultural Writing/Literature Project.

    ERIC Educational Resources Information Center

    McClanahan, Lauren G.

    This paper reports on a case study of a U.S. high school literature class during an e-mail exchange with a high school literature class in Moscow (Russia). During this project, the students in both classrooms read short stories by Anton Chekhov and O'Henry. By using the stories as a catalyst, the students' goal was to help their distant partner to…

  5. Conical Lens for 5-Inch/54 Gun Launched Missile

    DTIC Science & Technology

    1981-06-01

    Propagation, Interferenceand Diffraction of Light, 2nd ed. (revised), p. 121-124, Pergamon Press, 1964. 10. Anton , Howard, Elementary Linear Algebra , p. 1-21...equations is nonlinear in x, but is linear in the coefficients. Therefore, the techniques of linear algebra can be used on equation (F-13). The method...This thesis assumes the air to be homogenous, isotropic, linear , time indepen- dent (HILT) and free of shock waves in order to investigate the

  6. Control Strategies for Guided Collective Motion

    DTIC Science & Technology

    2015-02-27

    Rorres and H. Anton , “ Elementary linear algebra applications version,” 9th Edition, Wiley India Pvt. Ltd., 2011. [20] S.H. Strogatz, “From Kuramoto to... linear cyclic pursuit in which an agent pursues its leader with an angle of deviation. The sufficient conditions for the stability of such systems are...Generalized Hierarchical Cyclic Pursuit 6. D. Mukherjee and D. Ghose: Deviated Linear Cyclic Pursuit 7. D. Mukherjee and D. Ghose; On Synchronous and

  7. USAF Summer Research Program - 1993 Graduate Student Research Program Final Reports, Volume 6, AEDC, FJSRL and WHMC

    DTIC Science & Technology

    1993-12-01

    Mechanical Engineering Associate, PhD Laboratory: PL/VT Division Engineering University of Texas, San Anton Vol-Page No: 3-26 San Antonio, TX 7824-9065...parameters. The modules can be primitive or compound. Primitive modules represent the elementary computation units and define their interfaces. The... linear under varying conditions for the range of processor numbers. Discussion Performance: Our evaluation of the performance measurement results is the

  8. Naval Research Logistics Quarterly. Volume 28. Number 3,

    DTIC Science & Technology

    1981-09-01

    denotes component-wise maximum. f has antone (isotone) differences on C x D if for cl < c2 and d, < d2, NAVAL RESEARCH LOGISTICS QUARTERLY VOL. 28...or negative correlations and linear or nonlinear regressions. Given are the mo- ments to order two and, for special cases, (he regression function and...data sets. We designate this bnb distribution as G - B - N(a, 0, v). The distribution admits only of positive correlation and linear regressions

  9. USSR and Eastern Europe Scientific Abstracts, Electronics and Electrical Engineering, Number 33.

    DTIC Science & Technology

    1977-09-27

    reduces to an infinite system of linear homogeneous algebraic equations and leads to Mathieu functions of the k-th order. The solution is convergent in...cylinder walls to be infinitesimally thin ideal conductors. The problem is reduced to a system of Fredholm linear algebraic equations of the second...EXPECTED DEVELOPMENTS OF TRANSISTORIZED LOW-NOISE MICROWAVE AMPLIFIERS Prague SDELOVACI TECHNIKA in Czech Vol 25, No 2, Feb 77 pp 47-49 TALLO, ANTON

  10. An Extended Microcomputer-Based Network Optimization Package.

    DTIC Science & Technology

    1982-10-01

    Analysis, Laxenberq, Austria, 1981, pp. 781-808. 9. Anton , H., Elementary Linear Algebra , John Wiley & Sons, New York, 1977. 10. Koopmans, T. C...fCaRUlue do leVee. aide It 001100"M OW eedea9f’ OF Nooke~e Network, generalized network, microcomputer, optimization, network with gains, linear ...Oboe &111111041 network problem, in turn, can be viewed as a specialization of a linear programuing problem having at most two non-zero entries in each

  11. Control Strategies for Guided Collective Motion

    DTIC Science & Technology

    2015-01-30

    Control, Atlanta, GA, USA, December 2010, pp. 5468-5473. [19] C. Rorres and H. Anton , “ Elementary linear algebra applications version,” 9th Edition...work addresses and analyses deviated linear cyclic pursuit in which an Distribution Code A: Approved for public release, distribution is unlimited...Pursuit 6. D. Mukherjee and D. Ghose: Deviated Linear Cyclic Pursuit 7. D. Mukherjee and D. Ghose; On Synchronous and Asynchronous Heterogeneous Cyclic

  12. Pulse Height Analyzer Interfacing and Computer Programming in the Environmental Laser Propagation Project

    DTIC Science & Technology

    1976-06-01

    United States Naval Postgraduate School, Monterey , California, 1974. 6. Anton , H., Elementary Linear Algebra , John Wiley & Sons, 1973. 7. Parrat, L. G...CONVERTER ln(laser & bias) PULSE HEIGHT ANALYZER © LINEAR AMPLIFIER SAMPLE TRIGGER OSCILLATOR early ln(laser & bias) SCINTILLOMETERS recent BACKGROUND...DEMODULATOR LASER CALIBRATION BOX LASER OR CAL VOLTAGE LOG CONVERTER LN (LASER OR CAL VOLT) LINEAR AMPLIFIER uLN (LASER OR CAL VOLT) PULSE HEIGHTEN ANALYZER V

  13. A Search for Mountain Waves in MLS Stratospheric Limb Radiances from the Winter Northern Hemisphere: Data Analysis and Global Mountain Wave Modeling

    DTIC Science & Technology

    2004-02-11

    the general circulation of the middle atmosphere, Philos. Trans. R. Soc. London, Ser. A, 323, 693–705. Anton , H. (2000), Elementary Linear Algebra ...Because the saturated radiances may depend slightly on tangent height as the limb path length decreases, a linear trend (described by parameters a and b...track days and interpolated onto the same limb-track orbits. The color bar scale for radiance variance is linear . (b) Digital elevations of northern

  14. Predicting the Underwater Sound of Moderate and Heavy Rainfall from Laboratory Measurements of Radiation from Single Large Raindrops

    DTIC Science & Technology

    1992-03-01

    Elementary Linear Algebra with Applications, pp. 301- 323, John Wiley and Sons Inc., 1987. Atlas, D., and Ulbrich, C. E. W., "The Physical Basis for...vector drd In this case, the linear system is said to be inconsistent ( Anton and Rorres, 1987). In contrast, for an underdetermined system (where the...ocean acoustical tomography and seismology. In simplest terms, the general linear inverse problem consists of fimding the desired solution to a set of m

  15. RI: Rheology as a Tool for Understanding the Mechanics of Live Ant Aggregations, Part 2

    DTIC Science & Technology

    2016-11-04

    measure rheological properties of biological fluids. Using this machine, we were able to characterize non-Newtonian fluids such as frog saliva...order to measure rheological properties of biological fluids. Using this machine, we were able to characterize non-Newtonian fluids such as frog...GA, 30332 Objective An Anton Parr MCR 501 rheometer was purchased in order to measure rheological properties of biological fluids. Using this

  16. Eurasianism: A Historical and Contemporary Context

    DTIC Science & Technology

    2015-03-01

    Foreign Affairs, March 31, 2014, http://www.foreignaffairs.com/articles/141080/anton-barbashin-and-hannah-thoburn/putins-brain. 2 Dina Newman , “Russian...Eurasianism: An Ideology of Empire (Baltimore: Johns Hopkins Press, 2008), trans. Mischa Gabowitsch, 142. 4 Dina Newman , “Russian Nationalist...Russian Eurasiansim – Historiosophy and Ideology,” 106. 17 his parents were renowned poets) and as such, he faced difficulty in gaining

  17. Ionic Attachment as a Feasible Approach to Heterogenizing Anionic Solution Catalysts. The Carbonylation of Methanol,

    DTIC Science & Technology

    1980-08-01

    carbonylation of methanol to acetic acid reaction is well suited for a demonstration of the feasibility and value of ionically binding a catalyst to a...approximate doubling of the reaction rate. This result suggests that a liquid flow system design in which there is a large catalyst to methanol ratio could...Heterogenizing Anionic Solution Catalysts . The Carbonylation of Methanol by Russell S. Drago, Eric D. Nyberg, Anton El A’mma and Alan Zombeck ABSTRACT -’Few

  18. Electro-Optical and Optical Components for Processor to Processor Interconnects

    DTIC Science & Technology

    2013-04-01

    Kwiat and others were instrumental in explicitly co-entangling other properties such as momentum (path) [4]. Others such as Barnett and Zeilinger ...19 4. References: 1. D. Bouwmeester, J.W. Pan, K. Mattle, M. Eibl, H. Weinfurter and A. Zeilinger , “Experimental quantum teleportation...Nature, Vol. 390, 11 December 1997, pp. 575- 579. 2. Jian-Wei Pan, Dik Bouwmeester, Harald Weinfurter, and Anton Zeilinger , “Experimental Entanglement

  19. Expedition 30 Landing

    2012-04-28

    Expedition 30 Flight Engineer Anatoly Ivanishin is welcomed home by colleagues and family in Star City, Russia on Saturday, April 28, 2012. Russian Cosmonaut Ivanishin, Expedition 30 Commander Daniel Burbank, and Russian Cosmonaut Anton Shkaplerov landed outside of Arkalyk, Kazakhstan earlier in the day from over five months onboard the International Space Station where they served as members of the Expedtion 29 and 30 crews. Photo Credit: (NASA/Carla Cioffi)

  20. Expedition 30 Landing

    2012-04-28

    Expedition 30 Flight Engineers Anatoly Ivanishin, far left, and Anton Shkaplerov are welcomed home by colleagues and family in Star City, Russia on Saturday, April 28, 2012. Russian Cosmonauts Ivanishin, Shkaplerov and Expedition 30 Commander Daniel Burbank landed outside of Arkalyk, Kazakhstan earlier in the day from over five months onboard the International Space Station where they served as members of the Expedtion 29 and 30 crews. Photo Credit: (NASA/Carla Cioffi)

  1. Distinct, crucial roles of flavonoids during legume nodulation.

    PubMed

    Subramanian, Senthil; Stacey, Gary; Yu, Oliver

    2007-07-01

    RNA interference-mediated silencing of the key flavonoid and isoflavone biosynthesis enzyme, respectively, by two different research groups has provided direct genetic evidence for the essential roles that these compounds play in nodulation. Anton Wasson et al. have shown that flavonoids are essential for localized auxin transport inhibition during nodulation in the indeterminate legume Medicago truncatula. By contrast, Senthil Subramanian et al. have shown that isoflavones are essential for endogenous nod gene induction in the determinate legume soybean.

  2. Influences on Tobacco Control Funding Decisions: Explaining State Variation in Appropriations

    DTIC Science & Technology

    2003-01-01

    prevent morbidity and mortality and reduce costs in the future (Aldana, 2001; Harris, Holman, Carande- Kulis , 2001). However, health promotion...control is a core public health function with annual funding of national prevention programs, basic and applied research, technical assistance, and...common actions (Anton, 1989). As an example, primary authority for public education resides at the county level, but state and federal governments may

  3. Application of Artificial Boundary Conditions in Sensitivity-Based Updating of Finite Element Models

    DTIC Science & Technology

    2007-06-01

    is known as the impedance matrix[ ]( )Z Ω . [ ] [ ] 1( ) ( )Z H −Ω = Ω (12) where [ ] 2( )Z K M j C ⎡ ⎤Ω = −Ω + Ω⎣ ⎦ (13) A. REDUCED ORDER...D.L. A correlation coefficient for modal vector analysis. Proceedings of 1st International Modal Analysis Conference, 1982, 110-116. Anton , H ... Rorres , C ., (2005). Elementary Linear Algebra. New York: John Wiley and Sons. Avitable, Peter (2001, January) Experimental Modal Analysis, A Simple

  4. Coherent Change Detection: Theoretical Description and Experimental Results

    DTIC Science & Technology

    2006-08-01

    373–376. 47. S. M. Kay, Fundamentals of statistic signal processing. Vol 2. Detection theory. Pren- tice Hall, 1998. 48. H . Anton and C . Rorres ...Proceedings of the 1998 International Geoscience and Remote Sensing Symposium, vol. 5, 1998, pp. 2451–2453. 9. C . V. Jakowatz Jr., D. E. Wahl, P. H . Eichel...dissertation, School of Electrical and Electronic Engineering, The University of Adelaide, 2004. 20. C . H . Gierull, Statistics of SAR interferograms

  5. Expedition 42 Crew Wave

    2014-11-24

    Expedition 42 Flight Engineer Samantha Cristoforetti, of the European Space Agency (ESA), top, Flight Engineer Terry Virts of NASA, center, and Soyuz Commander Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos), bottom, wave farewell prior to boarding the Soyuz TMA-15M spacecraft for launch, Monday, Nov. 24, 2014 at the Baikonur Cosmodrome in Kazakhstan. Cristoforetti, Virts, and Shkaplerov will spend the next five and a half months aboard the International Space Station. Photo Credit: (NASA/Aubrey Gemignani)

  6. PKC Epsilon: A Novel Oncogenic Player in Prostate Cancer

    DTIC Science & Technology

    2014-09-01

    cancer. Clin Cancer Res 15: 4799-4805. 3 Neto, A. S., Tobias-Machado, M., Wroclawski, M. L., Fonseca , F. L., Pompeo, A. C., Del Giglio, A. (2010...biological chemistry 268: 6090-6096. 19 Perletti, G. P., Folini, M., Lin, H. C., Mischak, H., Piccinini, F., Tashjian, A. H., Jr. ( 1996 ). Overexpression...7737. 36 Aparicio Gallego, G., Diaz Prado, S., Jimenez Fonseca , P., Garcia Campelo, R., Cassinello Espinosa, J., Anton Aparicio, L. M. (2007

  7. VEG-03 Consmption Harvest no. 1

    2018-03-11

    iss055e001536 (March 8, 2018) --- Expedition 55 Commander Anton Shkaplerov eats a piece of lettuce harvested as part of the ongoing space crop study VEG-03. The botany experiment uses the Veggie plant growth facility to cultivate a type of cabbage, lettuce and mizuna which are harvested on-orbit with some samples consumed by astronauts and others returned to Earth for testing.

  8. An Integrity Framework for Image-Based Navigation Systems

    DTIC Science & Technology

    2010-06-01

    Anton H. and Rorres C. Elementary Linear Algebra . New York, NY: John Wiley & Sons, Inc., 2000. 4. Arthur T. “The Disparity of Parity, Determining...107. Spilker , James J.J. Digital Communications by Satellite. Englewood Cliffs NJ: Prentice Hall, 1977. 108. Strang G. Linear Algebra and its...2.3 The Linearized and Extended Kalman Filters . . . . . . 22 2.3.1 State and Measurement Model Equations . . . 23 2.3.2 The Linearized Kalman Filter

  9. Anatomy of a Silicon Compiler

    DTIC Science & Technology

    1994-10-04

    Recognition 321 Anton StOWz*e 21.1. ALGORITHM AND ARCHITECTURE ............... 322 21.2. SYSTEM ARCHITECTURE .................... 325 213. CHIP ARCHiTECTURES...age controlled switch. The second is a linear model where each transistor is mod- eled by a voltage controlled switch in series with a resistor, and...the blocks being co- linear . Routing channels separate blocks which are adjacent. Channels are also placed along the top edge of each block in order to

  10. Equality judgments cannot distinguish between attention effects on appearance and criterion: a reply to Schneider (2011).

    PubMed

    Anton-Erxleben, Katharina; Abrams, Jared; Carrasco, Marisa

    2011-01-01

    Whether attention modulates the appearance of stimulus features is debated. Whereas many previous studies using a comparative judgment have found evidence for such an effect, two recent studies using an equality judgment have not. Critically, these studies have relied on the assumption that the equality paradigm yields bias-free PSE estimates and is as sensitive as the comparative judgment, without testing these assumptions. Anton-Erxleben, Abrams, and Carrasco (2010) compared comparative judgments and equality judgments with and without the manipulation of attention. They demonstrated that the equality paradigm is less sensitive than the comparative judgment and also bias-prone. Furthermore, they reported an effect of attention on the PSE using both paradigms. Schneider (2011) questions the validity of the latter finding, stating that the data in the equality experiment are corrupted because of skew in the response distributions. Notably, this argument supports the original conclusion by Anton-Erxleben et al.: that the equality paradigm is bias-prone. Additionally, the necessary analyses to show that the attention effect observed in Anton-Erxleben et al. was due to skew in the data were not conducted. Here, we provide these analyses and show that although the equality judgment is bias-prone, the effects we observe are consistent with an increase of apparent contrast by attention.

  11. Equality judgments cannot distinguish between attention effects on appearance and criterion: A reply to Schneider (2011)

    PubMed Central

    Anton-Erxleben, Katharina; Abrams, Jared; Carrasco, Marisa

    2012-01-01

    Whether attention modulates the appearance of stimulus features is debated. Whereas many previous studies using a comparative judgment have found evidence for such an effect, two recent studies using an equality judgment have not. Critically, these studies have relied on the assumption that the equality paradigm yields bias-free PSE estimates and is as sensitive as the comparative judgment, without testing these assumptions. Anton-Erxleben, Abrams, and Carrasco (2010) compared comparative judgments and equality judgments with and without the manipulation of attention. They demonstrated that the equality paradigm is less sensitive than the comparative judgment and also bias-prone. Furthermore, they reported an effect of attention on the PSE using both paradigms. Schneider (2011) questions the validity of the latter finding, stating that the data in the equality experiment are corrupted because of skew in the response distributions. Notably, this argument supports the original conclusion by Anton-Erxleben et al.: that the equality paradigm is bias-prone. Additionally, the necessary analyses to show that the attention effect observed in Anton-Erxleben et al. was due to skew in the data were not conducted. Here, we provide these analyses and show that although the equality judgment is bias-prone, the effects we observe are consistent with an increase of apparent contrast by attention. PMID:22072728

  12. Convergence and reproducibility in molecular dynamics simulations of the DNA duplex d(GCACGAACGAACGAACGC).

    PubMed

    Galindo-Murillo, Rodrigo; Roe, Daniel R; Cheatham, Thomas E

    2015-05-01

    The structure and dynamics of DNA are critically related to its function. Molecular dynamics simulations augment experiment by providing detailed information about the atomic motions. However, to date the simulations have not been long enough for convergence of the dynamics and structural properties of DNA. Molecular dynamics simulations performed with AMBER using the ff99SB force field with the parmbsc0 modifications, including ensembles of independent simulations, were compared to long timescale molecular dynamics performed with the specialized Anton MD engine on the B-DNA structure d(GCACGAACGAACGAACGC). To assess convergence, the decay of the average RMSD values over longer and longer time intervals was evaluated in addition to assessing convergence of the dynamics via the Kullback-Leibler divergence of principal component projection histograms. These molecular dynamics simulations-including one of the longest simulations of DNA published to date at ~44μs-surprisingly suggest that the structure and dynamics of the DNA helix, neglecting the terminal base pairs, are essentially fully converged on the ~1-5μs timescale. We can now reproducibly converge the structure and dynamics of B-DNA helices, omitting the terminal base pairs, on the μs time scale with both the AMBER and CHARMM C36 nucleic acid force fields. Results from independent ensembles of simulations starting from different initial conditions, when aggregated, match the results from long timescale simulations on the specialized Anton MD engine. With access to large-scale GPU resources or the specialized MD engine "Anton" it is possible for a variety of molecular systems to reproducibly and reliably converge the conformational ensemble of sampled structures. This article is part of a Special Issue entitled: Recent developments of molecular dynamics. Copyright © 2014. Published by Elsevier B.V.

  13. Structural inheritance and selective reactivation in the central Andes: Cenozoic deformation guided by pre-Andean structures in southern Peru

    NASA Astrophysics Data System (ADS)

    Perez, Nicholas D.; Horton, Brian K.; Carlotto, Victor

    2016-03-01

    Structural, stratigraphic, and geochronologic constraints from the Eastern Cordillera in the central Andean plateau of southern Peru (14-15°S) demonstrate the existence and position of major pre-Andean structures that controlled the accumulation of Triassic synrift fill and guided subsequent Cenozoic deformation. The timing of initial clastic deposition of the Triassic Mitu Group is here constrained to ~ 242-233 Ma on the basis of detrital and volcanic zircon U-Pb geochronology. Regionally distinct provenance variations, as provided by U-Pb age populations from localized synrift accumulations, demonstrate Triassic erosion of multiple diagnostic sources from diverse rift-flank uplifts. Stratigraphic correlations suggest synchronous initiation of extensional basins containing the Mitu Group, in contrast with previous interpretations of southward rift propagation. Triassic motion along the NE-dipping San Anton normal fault accommodated up to 7 km of throw and hanging-wall deposition of a synrift Mitu succession > 2.5 km thick. The contrasting orientation of a non-reactivated Triassic normal fault suggests selective inversion of individual structures in the Eastern Cordillera was dependent on fault dip and strike. Selective preservation of a ~ 4 km thick succession of Carboniferous-Permian strata in the down-dropped San Anton hanging wall, beneath the synrift Mitu Group, suggests large-scale erosional removal in the uplifted footwall. Field and map observations identify additional pre-Andean thrust faults and folds attributed to poorly understood Paleozoic orogenic events preserved in the San Anton hanging wall. Selective thrust reactivation of normal and reverse faults during later compression largely guided Cenozoic deformation in the Eastern Cordillera. The resulting structural compartmentalization and across-strike variations in kinematics and deformation style highlight the influence of inherited Paleozoic structures and Triassic normal faults on the long

  14. jsc2011e027535

    2011-03-21

    At the Baikonur Cosmodrome in Kazakhstan, Expedition 27 Flight Engineer Ron Garan of NASA (left), Soyuz Commander Alexander Samokutyaev (center) and Flight Engineer Andrey Borisenko (right) are greeted upon their arrival March 21, 2011 by RSC-Energia Vice-President Nikolai Zelenchikov after their flight to the launch site from Star City, Russia. The trio, and their backups, Anatoly Ivanishin, Anton Shkaplerov and Dan Burbank are in the final weeks of training for their launch April 5 (April 4, U.S. time) on the Soyuz TMA-21 spacecraft to the International Space Station. Credit: NASA/Victor Zelentsov

  15. The Perseids Aug 11-12, 1996 in Bulgaria

    NASA Astrophysics Data System (ADS)

    Bojurova, E.; Trukchev, I.

    As every year Astroclub "Canopus" organized an extended Perseid observing campaign. Members of the club took part in expedition to Avren village near Varna, at the National Astronomical Observatory (Rojen) and at the National Yought Astronomical Camp in Belite Brezi (South Bulgaria). Here we present some results derived on the basis of data obtained by Biliana Ognianova, Diana Tisheva, Diliana Antonova, Eva Bojurova, Elena Surbinska, Irena Stavreva, Katia Koleva, Lilia Porojanova, Anton Antonov, Denis Mechmedov, Doichin Docinski, Galin Genchev, Ivan Trukhchev, Valentin Velkov. More than 2000 Perseids were recorded. Some other showers were also observed.

  16. jsc2014e092329

    2014-11-06

    4108: At the Kremlin Wall in Red Square in Moscow, Expedition 42/43 crewmember Samantha Cristoforetti of the European Space Agency lays flowers Nov. 6 at the site where Russian space icons are interred. Cristoforetti, Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) and Terry Virts of NASA will launch Nov. 24, Kazakh time from the Baikonur Cosmodrome in Kazakhstan on their Soyuz TMA-15M spacecraft for a 5 ½ month mission on the International Space Station. NASA/Stephanie Stoll

  17. [The early history of "Ecstasy"].

    PubMed

    Benzenhöfer, U; Passie, T

    2006-01-01

    There is no consensus in the literature regarding the early history of MDMA (Methylendioxymethamphetamine, so-called "Ecstasy"). Various authors credit the first synthesis of MDMA to the German chemist Fritz Haber, but it appears neither in his doctoral thesis (Berlin 1891) nor in his accompanying articles. The man who first synthesized MDMA was the chemist Dr. Anton Köllisch, who worked for the German pharmaceutical company Merck. He created MDMA as a by-product while trying to synthesize hydrastinin, a styptic substance. In 1912, Merck filed to patent the applied method of preparation. The patent was issued in 1914, yet no pharmaceutical testing followed at that time.

  18. Change of Command

    2011-11-20

    ISS029-E-043148 (20 Nov. 2011) --- Expedition 28/29 and Expedition 29/30 crew members pose for a group portrait in the International Space Station?s Kibo laboratory following the ceremony of Changing-of-Command from Expedition 29 to Expedition 30. Pictured from the left are Russian cosmonaut Anatoly Ivanishin, Expedition 30 flight engineer; NASA astronaut Dan Burbank, Expedition 30 commander; Anton Shkaplerov, Expedition 30 flight engineer; Russian cosmonaut Sergei Volkov, Expedition 29 flight engineer; NASA astronaut Mike Fossum, Expedition 29 commander; and Japan Aerospace Exploration Agency astronaut Satoshi Furukawa, Expedition 29 flight engineer.

  19. Change of Command

    2011-11-20

    ISS029-E-043136 (20 Nov. 2011) --- Expedition 28/29 and Expedition 29/30 crew members pose for a group portrait in the International Space Station?s Kibo laboratory following the ceremony of Changing-of-Command from Expedition 29 to Expedition 30. Pictured on the front row are NASA astronauts Dan Burbank (left), Expedition 30 commander; and Mike Fossum, Expedition 29 commander. Pictured from the left (back row) are Russian cosmonauts Anatoly Ivanishin, and Anton Shkaplerov, both Expedition 30 flight engineers; and Sergei Volkov, Expedition 29 flight engineer; along with Japan Aerospace Exploration Agency astronaut Satoshi Furukawa, Expedition 29 flight engineer.

  20. Change of Command

    2011-11-20

    ISS029-E-043133 (20 Nov. 2011) --- Expedition 28/29 and Expedition 29/30 crew members pose for a group portrait in the International Space Station?s Kibo laboratory following the ceremony of Changing-of-Command from Expedition 29 to Expedition 30. Pictured on the front row are NASA astronauts Dan Burbank (left), Expedition 30 commander; and Mike Fossum, Expedition 29 commander. Pictured from the left (back row) are Russian cosmonauts Anatoly Ivanishin, and Anton Shkaplerov, both Expedition 30 flight engineers; and Sergei Volkov, Expedition 29 flight engineer; along with Japan Aerospace Exploration Agency astronaut Satoshi Furukawa, Expedition 29 flight engineer.

  1. Change of Command

    2011-11-20

    ISS029-E-043144 (20 Nov. 2011) --- Expedition 28/29 and Expedition 29/30 crew members pose for a group portrait in the International Space Station?s Kibo laboratory following the ceremony of Changing-of-Command from Expedition 29 to Expedition 30. Pictured from the left are Russian cosmonaut Anatoly Ivanishin, Expedition 30 flight engineer; NASA astronaut Dan Burbank, Expedition 30 commander; Anton Shkaplerov, Expedition 30 flight engineer; Russian cosmonaut Sergei Volkov, Expedition 29 flight engineer; NASA astronaut Mike Fossum, Expedition 29 commander; and Japan Aerospace Exploration Agency astronaut Satoshi Furukawa, Expedition 29 flight engineer.

  2. Soyuz-MS-07_Farewell-Hatch-Closure_June-3-2018_660949

    2018-06-04

    Expedition 55 Crew Lands Safely in Kazakhstan to Complete Almost Six Months In Space------ Expedition 55 Commander Anton Shkaplerov of Roscosmos and Flight Engineers Scott Tingle of NASA and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) landed safely near the town of Dzhezkazgan, Kazakhstan June 3 after bidding farewell to their colleagues on the complex and undocking their Soyuz MS-07 spacecraft from the Rassvet Module on the International Space Station. The trio spent almost six months in space conducting research and operational work in support of the station.

  3. Burbank and Shkaplerov review crew procedures

    2012-03-24

    ISS030-E-171107 (24 March 2012) --- NASA astronaut Dan Burbank (left), Expedition 30 commander; and Russian cosmonaut Anton Shkaplerov, flight engineer, wearing communication headsets, review crew procedures in the Zvezda Service Module of the International Space Station in preparation of moving to the appropriate Soyuz vehicles, due to the possibility that space debris could pass close to the station. Burbank, Shkaplerov and Ivanishin sheltered in the Soyuz TMA-22 spacecraft attached to the Poisk Mini-Research Module 2 (MRM2) while Kononenko, Kuipers and Pettit took to the Soyuz TMA-03M docked to the Rassvet Mini-Research Module 1 (MRM-1).

  4. Burbank, Shkaplerov, and Kuipers review crew procedures

    2012-03-24

    ISS030-E-171111 (24 March 2012) --- NASA astronaut Dan Burbank (left), Expedition 30 commander; along with Russian cosmonaut Anton Shkaplerov (center) and European Space Agency astronaut Andre Kuipers, both flight engineers, review crew procedures in the Zvezda Service Module of the International Space Station in preparation of moving to the appropriate Soyuz vehicles, due to the possibility that space debris could pass close to the station. Burbank, Shkaplerov and Ivanishin sheltered in the Soyuz TMA-22 spacecraft attached to the Poisk Mini-Research Module 2 (MRM2) while Kononenko, Kuipers and Pettit took to the Soyuz TMA-03M docked to the Rassvet Mini-Research Module 1 (MRM-1).

  5. Human Respiratory Responses during High Performance Flight

    DTIC Science & Technology

    1987-11-01

    of walking in chemical defence clothing. RAF Institute of Aviation Medicine Aircrew Equipment Group Report No 347 , 1975. 95 Gibson T M, Anton D...1.05 1.01 1.15 1.07 0.0391 0.6223 0.C243 2 Taxy (pre-flight) . 1.00 1.01 1.05 1.08 1.02 0.0296 0.4187 0.0124 1 Jako -oft . 1.09 - 1.13 1.15 1.55 1.14

  6. jsc2017e137338 - At the Cosmonaut Hotel crew quarters in Baikonur, Kazakhstan, Expedition 54-55 prime crewmember Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) tries his hand at a game of billiards Dec. 11 during a break in pre-launch tr

    2017-12-11

    jsc2017e137338 - At the Cosmonaut Hotel crew quarters in Baikonur, Kazakhstan, Expedition 54-55 prime crewmember Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) tries his hand at a game of billiards Dec. 11 during a break in pre-launch training while backup crewmember Jeanette Epps of NASA looks on. Kanai, Scott Tingle of NASA and Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) will launch Dec. 17 on the Soyuz MS-07 spacecraft from the Baikonur Cosmodrome for a five month mission on the International Space Station...Andrey Shelepin / Gagarin Cosmonaut Training Center.

  7. jsc2017e137337 - At the Cosmonaut Hotel crew quarters in Baikonur, Kazakhstan, Expedition 54-55 prime crewmember Scott Tingle of NASA plays a game of chess Dec. 11 during a break in his pre-launch training. Tingle, Norishige Kanai of the Japan Aerospace E

    2017-12-11

    jsc2017e137337 - At the Cosmonaut Hotel crew quarters in Baikonur, Kazakhstan, Expedition 54-55 prime crewmember Scott Tingle of NASA plays a game of chess Dec. 11 during a break in his pre-launch training. Tingle, Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) and Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) will launch Dec. 17 on the Soyuz MS-07 spacecraft from the Baikonur Cosmodrome for a five month mission on the International Space Station...Andrey Shelepin / Gagarin Cosmonaut Training Center.

  8. A Default Temporal Logic for Regulatory Conformance Checking

    DTIC Science & Technology

    2008-04-01

    proofs. In Section 4.3, we provide an axiomatization using Fitting’s sequent calculus [25]. Completeness is proved in Section 4.4. We conclude, in...axiomatize RefL. 4.3 Sequent Calculus We use Fitting’s sequent calculus [25]. A sequent is a statement of the form Γ → ∆, where Γ and ∆ are finite sets of...T.D., Vail, M.W., Anton , A.I.: Towards regulatory compliance: Extracting rights and obligations to align requirements with regulations. In

  9. Earth observation taken by the Expedition 43 crew

    2015-04-01

    ISS043E080914 (04/01/2015) --- This Earth view from the International Space Station Apr. 1, 2015 (bottom left corner) is Soyuz TMA-15M which carried NASA astronaut Terry Virts, ESA (European Space Agency) astronaut Samantha Cristoforetti and Russian cosmonaut Anton Shkaplerov to the ISS back in No. 2014 and will remain until May 2015. The further one (top left corner) is Progress 57 a Russian supply spaceship which launched and docked in October last year and will undock at the end of April to return to Earth.

  10. Expedition 30 Landing

    2012-04-27

    NASA and GCTC (Gagarin Cosmonaut Training Center) crew support personnel enter the inflatable medical tent in which Expedition 30 Commander Dan Burbank, and flight engineers Anton Shkaplerov and Anatoly Ivanishin are being checked out shortly after their Soyuz TMA-22 capsule landed out side the town of Arkalyk, Kazakhstan, Friday, April 27, 2012. Burbank, and Russian Cosmonauts Shkaplerov and Ivanishin are returning from more than five months onboard the International Space Station where they served as members of the Expedition 29 and 30 crews. Photo Credit: (NASA/Carla Cioffi)

  11. iss054e027048

    2018-02-02

    iss054e027048 (Feb. 2, 2018) --- A Russian spacewalker is seen in an Orlan spacesuit with blue stripes (center image) working outside the Zvezda service module during the longest spacewalk in Russian space program history on Feb. 2, 2018. Cosmonauts Alexander Misurkin and Anton Shkaplerov wrapped up the eight hour and 13 minute spacewalk after installing a new electronics and telemetry box for the high gain antenna on Zvezda. The new gear will enhance communications between Russian flight controllers and the Russian modules.

  12. Accuracy Assessment for the Auxillary Tracking System

    DTIC Science & Technology

    1991-09-01

    Auxiliary Tracking System (ATS), paper prepared for evaluation of ATS design review, 28 June, 1990. Anton , H., and Rorres, C., Elementary Linear Algebra with...are linearized around the trial value (XT6, YT,, Zro), shown in Equation 3.16, where 10 means evaluated at point "o". The OR1aI * YaT- I T.) ZR (ZT...3.16) partial derivatives are listed in Equations 3.17 through 3.19. 8XR.[ o 7.-OR1 [ .XT-XL (3.17) aOR., ZTo-Z 1 (3.19) aZTIo R. The linearized

  13. Darwin: German mystic or French rationalist?

    PubMed

    Ghiselin, Michael T

    2015-01-01

    The notion that Charles Darwin embraced the German Romantic tradition seems plausible, given the early influence of Alexander von Humboldt. But this view fails to do justice to other scientific traditions. Darwin was a protégé of the Englishman John Stevens Henslow and was a follower of the Scott Charles Lyell. He had important debts to French scientists, notably Henri Milne-Edwards, Etienne and Isidore Geoffroy Saint-Hilaire, and Alphonse de Candolle. Many Germans were quite supportive of Darwin, but not all of these were encumbered by idealistic metaphysical baggage. Both Darwin and Anton Dohrn treated science as very much a cosmopolitan enterprise.

  14. New crew launches to ISS on This Week @NASA - November 28, 2014

    2014-11-28

    NASA’s Terry Virts and Expedition 42/43 crewmates, Anton Shkaplerov of the Russian Federal Space Agency and the European Space Agency’s Samantha Cristoforetti, launched Nov. 23 at 4:01 p.m. Eastern Standard Time, from Baikonur, Kazakhstan. Almost six hours later, their Soyuz spacecraft docked to the International Space Station – where they joined Expedition 42 Commander Barry Wilmore of NASA, and Flight Engineers Alexander Samokutyaev and Elena Serova of Roscosmos – returning the station crew to its full complement of six people. Also, First 3-D printed object in space, Orion flight test update, New airborne Earth Science missions and Happy Thanksgiving from space!

  15. Space Station Cosmonauts Walk in Space to Upgrade Communications Hardware

    2018-02-02

    Aboard the International Space Station, Expedition 54 Flight Engineers Alexander Misurkin and Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) conducted a spacewalk outside the Pirs docking compartment Feb. 2 to install a new high-gain communications antenna on the aft end of the Zvezda Service Module and retrieve science experiment packages from the hull of the module. It was the 208th spacewalk in support of space station assembly and maintenance, the fourth in Misurkin’s career and the second for Shkaplerov.

  16. Chemical Analysis of the Dyes Used in Navy Green and Yellow Colored Smokes .

    DTIC Science & Technology

    1986-01-31

    RD-RI69 478 CHEMICAL ANALYSIS OF THE DYES USED IN NAVY OREEN AND 11 YELLOW COLORED SNOKES(U) NAVAL WEAPONS SUP POR T CENTER CRANE IN APPLIED SCIENCES...NWSC/CR/RDTR-271 00 CHEMICAL ANALYSIS OF THE DYES USED IN NAVY GREEN AND YELLOW COLORED SMOKES Anton Chin Naval Weapons Support Center Applied Sciences...62765 SF65-559 559-691 20392 TITLE (Iint/ude Sec uritE C/assitication) CHEMICAL ANALYSIS OF THE DYES USED IN NAVY GREEN AND YELLOW COLORED SMOKES 1.1

  17. JAXA PAO VIP Event 3318_624493_hires

    2018-03-05

    SPACE STATION CREW DISCUSSES LIFE IN SPACE WITH JAPANESE OFFICIALS --------------------------------------------------------- Aboard the International Space Station, Expedition 55 Commander Anton Shkaplerov of Roscosmos and Flight Engineers Scott Tingle of NASA and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) discussed life and research on the orbital laboratory during an in-flight question and answer session March 3 with Japanese space officials and policy ministers attending the International Space Explorers Forum (ISEF-2) in Tokyo. The trio is in the midst of a five-and-a-half-month mission on the station.

  18. Dispersion Strengthening of High Temperature Niobium Alloys

    DTIC Science & Technology

    1988-05-31

    Fig. 2 for the alloys containing ZrC and Ta6 Si3 respectively. The former shows classical age .hardening response with hardening followed by softening...tILE COP) ION STRENGTH’ENING OF HIGH TEMATURE NIOBIUM ALLOYS Prepared by D.L. Anton 00 D.B. Snow In) A.F. Giamei ANNUAL REPORT Contract F49620486-C...Center / ni .’ - k- ADDRESS (Ciy, State, and ZIP Code) 7b ADDRESS (City, State, and ZIP Code) East Hartford, CT 06108 7-Jc\\ 4 0 _ .F3 A.C 8a. NAME OF

  19. Pigment characterization of important golden age panel paintings of the 17th century

    NASA Astrophysics Data System (ADS)

    Pięta, Ewa; Proniewicz, Edyta; Szmelter-Fausek, Bożena; Olszewska-Świetlik, Justyna; Proniewicz, Leonard M.

    2015-02-01

    Samples were obtained from two world-famous 17th century panel paintings of the Gdańsk school of panting: 'Seven Acts of Charity' (1607, in St. Mary's Church in Gdańsk, Poland) by Anton Möller and 'Angelic Concert' (1611, in Diocesan Museum in Pelplin, Poland) by Hermann Han. Micro-Raman spectroscopy (MRS), optical microscopy (OM), and X-ray fluorescence (XRF) spectroscopy studies of the samples were performed to characterize the pigments present in the individual painting layers (a rich palette of white, black, blue, red, and yellow pigments) and the pictorial techniques used by the artists.

  20. jsc2014e092317

    2014-11-06

    3851: At the Gagarin Cosmonaut Training Center in Star City, Russia, Expedition 42/43 crewmember Samantha Cristoforetti of the European Space Agency (right) signs a ceremonial book Nov. 6 as her crewmates, Terry Virts of NASA (left) and Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos, center) look on. Virts, Cristoforetti and Shkaplerov will launch Nov. 24, Kazakh time from the Baikonur Cosmodrome in Kazakhstan on their Soyuz TMA-15M spacecraft for a 5 ½ month mission on the International Space Station. NASA/Stephanie Stoll

  1. jsc2017e135207 - At the Gagarin Cosmonaut Training Center in Star City, Russia, Expedition 54-55 prime crewmember Norishige Kanai of the Japan Aerospace Exploration Space Agency (JAXA) listens to a reporters’ question Nov. 29 as part of the crew’s fin

    2017-11-29

    jsc2017e135207 - At the Gagarin Cosmonaut Training Center in Star City, Russia, Expedition 54-55 prime crewmember Norishige Kanai of the Japan Aerospace Exploration Space Agency (JAXA) listens to a reporters’ question Nov. 29 as part of the crew’s final qualification exam activities. Kanai, Scott Tingle of NASA and Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) will launch Dec. 17 on the Soyuz MS-07 spacecraft from the Baikonur Cosmodrome in Kazakhstan for a five-month mission on the International Space Station...NASA/Elizabeth Weissinger.

  2. Applied Mathematical Modules for Use in a Linear Algebra Service Course

    DTIC Science & Technology

    1990-05-01

    H . (1977). Elements of ohysical chemistry. Reading, MA: Addison-Wesley. Rorres , C . & Anton , H . (1984). Applications...k t)r+ v𔃽 A142"+ c -- + C Vt +1 t+ C c tKc cos t 2= 113 123 313 32-3 51 2 V - cu-14sin r t) 232 _E _ VL3 h 3kx3 Cl t + c1 _3 t c + 3 =11-3 12 3 31 6... H " O H H H o 0 0 H H H H H H Ao, //o\\ H HH H

  3. Analysis and Evaluation of Project EVERGREEN Data

    DTIC Science & Technology

    1991-09-01

    1 9 9c9" 9 9 9 91?t- VI vi rl i v AH AR AA R a- 6 4 h 1" t - 10 i h t -: .4 .a: : t : 3 t : ta at ~ ~’~ M ~4C ~ C0.~b ~ ~ qO ~ Cm @ el 0. z ~M C q f... Anton , Howard and Rorres , Chris, Elementary Linear Algebra with AyDlications, John Wiley and Sons, New York, 1987. 2. Binnall, Eugene P., EVERGREEN... C . ANALYSIS OF INDIVIDUAL WAVEFORMS.........52 1. Directory 5-1-90 . . . . . .. .. .. .. ... 58 a. Waveform NTSO4BO1.WFM............58 b. Waveform

  4. jsc2017e136049 - At the Gagarin Cosmonaut Training Center in Star City, Russia, Expedition 54-55 prime crewmember Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) listens to a reporter’s question during a crew news conference Nov. 30. Ka

    2017-11-30

    jsc2017e136049 - At the Gagarin Cosmonaut Training Center in Star City, Russia, Expedition 54-55 prime crewmember Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) listens to a reporter’s question during a crew news conference Nov. 30. Kanai, Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) and Scott Tingle of NASA will launch Dec. 17 on the Soyuz MS-07 spacecraft from the Baikonur Cosmodrome in Kazakhstan for a five-month mission on the International Space Station...Andrey Shelepin/Gagarin Cosmonaut Training Center.

  5. Expedition 55 Soyuz Docking

    2018-03-23

    Icons for the International Space Station and Soyuz MS-08 spacecraft are seen on a tracking map on a screen in the Moscow Mission Control Center as the spacecraft approaches for docking, Friday, March 23, 2018 in Korolev, Russia. The Soyuz MS-08 spacecraft carrying Expedition 55-56 crewmembers Oleg Artemyev of Roscosmos and Ricky Arnold and Drew Feustel of NASA docked at 3:40 p.m. Eastern time (10:40 p.m. Moscow time) on March 23 and joined Expedition 55 Commander Anton Shkaplerov of Roscosmos, Scott Tingle of NASA, and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA). Photo Credit: (NASA/Joel Kowsky)

  6. Expedition 54 Soyuz Docking

    2017-12-19

    Anton Shkaplerov of Roscosmos is seen after the opening of the hatches between the Soyuz MS-07 spacecraft and the International Space Station on the screens in the Moscow Mission Control Center in Korolev, Russia a few hours after the Soyuz MS-07 docked to the International Space Station on Tuesday, Dec. 19, 2017. Hatches were opened at 5:55 a.m. EST and Shkaplerov, Scott Tingle of NASA, and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) joined Expedition 54 Commander Alexander Misurkin of Roscosmos and crewmates Mark Vande Hei and Joe Acaba of NASA aboard the orbiting laboratory. Photo Credit: (NASA/Joel Kowsky)

  7. Expedition 54 Soyuz Docking

    2017-12-19

    NASA International Space Station Program Manager Kirk Shireman speaks with the Expedition 54 crew from the Moscow Mission Control Center in Korolev, Russia a few hours after the Soyuz MS-07 docked to the International Space Station on Tuesday, Dec. 19, 2017. Hatches were opened at 5:55 a.m. EST and Anton Shkaplerov of Roscosmos, Scott Tingle of NASA, and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) joined Expedition 54 Commander Alexander Misurkin of Roscosmos and crewmates Mark Vande Hei and Joe Acaba of NASA aboard the orbiting laboratory. Photo Credit: (NASA/Joel Kowsky)

  8. Expedition 54 Soyuz Docking

    2017-12-19

    Japan Aerospace Exploration Agency (JAXA) International Space Station Program Manager Koichi Wakata speaks with the Expedition 54 crew from the Moscow Mission Control Center in Korolev, Russia a few hours after the Soyuz MS-07 docked to the International Space Station on Tuesday, Dec. 19, 2017. Hatches were opened at 5:55 a.m. EST and Anton Shkaplerov of Roscosmos, Scott Tingle of NASA, and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) joined Expedition 54 Commander Alexander Misurkin of Roscosmos and crewmates Mark Vande Hei and Joe Acaba of NASA aboard the orbiting laboratory. Photo Credit: (NASA/Joel Kowsky)

  9. jsc2017e136060 - On a snowy night at Red Square in Moscow, Expedition 54-55 crewmember Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) lays flowers at the Kremlin Wall where Russian space icons are interred in traditional pre-launch cerem

    2017-11-30

    jsc2017e136060 - On a snowy night at Red Square in Moscow, Expedition 54-55 crewmember Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) lays flowers at the Kremlin Wall where Russian space icons are interred in traditional pre-launch ceremonies Nov. 30. Kanai, Scott Tingle of NASA and Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) will launch from the Baikonur Cosmodrome in Kazakhstan on the Soyuz MS-07 spacecraft Dec. 17 for a five-month mission on the International Space Station...Andrey Shelepin/Gagarin Cosmonaut Training Center.

  10. jsc2017e137339 - At the Cosmonaut Hotel crew quarters in Baikonur, Kazakhstan, Expedition 54-55 prime crewmember Scott Tingle of NASA tests his vestibular skills on a rotating chair Dec. 11 as part of his pre-launch training. Tingle, Norishige Kanai of th

    2017-12-11

    jsc2017e137339 - At the Cosmonaut Hotel crew quarters in Baikonur, Kazakhstan, Expedition 54-55 prime crewmember Scott Tingle of NASA tests his vestibular skills on a rotating chair Dec. 11 as part of his pre-launch training. Tingle, Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) and Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) will launch Dec. 17 on the Soyuz MS-07 spacecraft from the Baikonur Cosmodrome for a five month mission on the International Space Station...Andrey Shelepin / Gagarin Cosmonaut Training Center.

  11. jsc2017e137341 - At the Cosmonaut Hotel crew quarters in Baikonur, Kazakhstan, Expedition 54-55 prime crewmembers Scott Tingle of NASA (left) and Norishige Kanai of the Japan Aerospace Exploration Agency (right) test their vestibular skills on tilt tables

    2017-12-11

    jsc2017e137341 - At the Cosmonaut Hotel crew quarters in Baikonur, Kazakhstan, Expedition 54-55 prime crewmembers Scott Tingle of NASA (left) and Norishige Kanai of the Japan Aerospace Exploration Agency (right) test their vestibular skills on tilt tables Dec. 11 as part of their pre-launch training. Along with Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos), they will launch Dec. 17 on the Soyuz MS-07 spacecraft from the Baikonur Cosmodrome for a five month mission on the International Space Station...Andrey Shelepin / Gagarin Cosmonaut Training Center.

  12. jsc2014e093279

    2014-11-18

    6103: At the Cosmonaut Hotel crew quarters in Baikonur, Kazakhstan, Expedition 42/43 crewmember Samantha Cristoforetti of the European Space Agency tests her vestibular system on a tilt table Nov. 18 as part of pre-launch training. Cristoforetti, Terry Virts of NASA and Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) will launch Nov. 24, Kazakh time, from the Baikonur Cosmodrome in the Soyuz TMA-15M spacecraft for a 5 ½ month mission on the International Space Station. NASA/Sergei Fyodorov

  13. Creativity and mood disorders: The enigmatic case of Isaak Il'ich Levitan (1860-1900).

    PubMed

    Lerner, Vladimir; Margolin, Jacob; Witztum, Eliezer

    2017-05-01

    Isaak Levitan (1860-1900) was one of Russia's most influential landscape artists. He lived a very short life, only 40 years, but left more than 1000 paintings. He suffered from mood fluctuations, and died as a result of serious heart disease. After an introduction related to the issue of creativity and mental disorders, a short biography of Levitan's life is outlined, followed by some examples of his mood and behavior. A section on the mood's reflection in Levitan's professional work is followed by a description of his romantic loves and disappointments and his relationship with his contemporary Russian, the writer Anton Chekhov.

  14. Global motions exhibited by proteins in micro- to milliseconds simulations concur with anisotropic network model predictions

    NASA Astrophysics Data System (ADS)

    Gur, M.; Zomot, E.; Bahar, I.

    2013-09-01

    The Anton supercomputing technology recently developed for efficient molecular dynamics simulations permits us to examine micro- to milli-second events at full atomic resolution for proteins in explicit water and lipid bilayer. It also permits us to investigate to what extent the collective motions predicted by network models (that have found broad use in molecular biophysics) agree with those exhibited by full-atomic long simulations. The present study focuses on Anton trajectories generated for two systems: the bovine pancreatic trypsin inhibitor, and an archaeal aspartate transporter, GltPh. The former, a thoroughly studied system, helps benchmark the method of comparative analysis, and the latter provides new insights into the mechanism of function of glutamate transporters. The principal modes of motion derived from both simulations closely overlap with those predicted for each system by the anisotropic network model (ANM). Notably, the ANM modes define the collective mechanisms, or the pathways on conformational energy landscape, that underlie the passage between the crystal structure and substates visited in simulations. In particular, the lowest frequency ANM modes facilitate the conversion between the most probable substates, lending support to the view that easy access to functional substates is a robust determinant of evolutionarily selected native contact topology.

  15. Volumetric Properties, Viscosities, and Refractive Indices of the Binary Systems 1-Butanol + PEG 200, + PEG 400, and + TEGDME

    NASA Astrophysics Data System (ADS)

    Živković, N.; Šerbanović, S.; Kijevčanin, M.; Živković, E.

    2013-06-01

    Densities, viscosities, and refractive indices of three binary systems consisting of 1-butanol with polyethylene glycols of different molecular weights (PEG 200 and PEG 400) or tetraethylene glycol dimethyl ether (TEGDME) were measured at ten temperatures (288.15, 293.15, 298.15, 303.15, 308.15, 313.15, 318.15, 323.15, 328.15, and 333.15) K and atmospheric pressure. Densities of the selected binary mixtures were measured with an Anton Paar DMA 5000 digital vibrating U-tube densimeter, refractive indices were measured with an automatic Anton Paar RXA-156 refractometer, while for viscosity measurements, a digital Stabinger SVM 3000/G2 viscometer was used. From these data, excess molar volumes were calculated and fitted to the Redlich-Kister equation. The obtained results have been analyzed in terms of specific molecular interactions and mixing behavior between mixture components, as well as the influence of temperature on them. Viscosity data were also correlated by Grunberg-Nissan, Eyring-UNIQUAC, three-body McAlister, and Eyring-NRTL models.

  16. Alkylation of an active-site cysteinyl residue during substrate-dependent inactivation of Escherichia coli S-adenosylmethionine decarboxylase.

    PubMed

    Diaz, E; Anton, D L

    1991-04-23

    S-Adenosylmethionine decarboxylase from Escherichia coli is a member of a small class of enzymes that uses a pyruvoyl prosthetic group. The pyruvoyl group is proposed to form a Schiff base with the substrate and then act as an electron sink facilitating decarboxylation. We have previously shown that once every 6000-7000 turnovers the enzyme undergoes an inactivation that results in a transaminated pyruvoyl group and the formation of an acrolein-like species from the methionine moiety. The acrolein then covalently alkylates the enzyme [Anton, D. L., & Kutny, R. (1987) Biochemistry 26, 6444]. After reduction of the alkylated enzyme with NaBH4, a tryptic peptide with the sequence Ala-Asp-Ile-Glu-Val-Ser-Thr-[S-(3-hydroxypropyl)Cys]-Gly-Val-Ile-Ser-Pro - Leu-Lys was isolated. This corresponds to acrolein alkylation of a cysteine residue in the second tryptic peptide from the NH2 terminal of the alpha-subunit [Anton, D. L., & Kutny, R. (1987) J. Biol. Chem. 262, 2817-2822]. The modified residue derived is from Cys-140 of the proenzyme [Tabor, C. W., & Tabor, H. (1987) J. Biol. Chem. 262, 16037-16040] and lies in the only sequence conserved between rat liver and E. coli S-adenosylmethionine decarboxylase [Pajunen et al. (1988) J. Biol. Chem. 263, 17040-17049]. We suggest that the alkylated Cys residue could have a role in the catalytic mechanism.

  17. In vivo mechanism-based inactivation of S-adenosylmethionine decarboxylases from Escherichia coli, Salmonella typhimurium, and Saccharomyces cerevisiae

    PubMed Central

    Li, Yong-Fu; Hess, Sonja; Pannell, Lewis K.; Tabor, Celia White; Tabor, Herbert

    2001-01-01

    S-adenosylmethionine decarboxylase (AdoMetDC), a key enzyme in the biosynthesis of spermidine and spermine, is first synthesized as a proenzyme, which is cleaved posttranslationally to form α and β subunits. The α subunit contains a covalently bound pyruvoyl group derived from serine that is essential for activity. With the use of an Escherichia coli overexpression system, we have purified AdoMetDCs encoded by the E. coli, Saccharomyces cerevisiae, and Salmonella typhimurium genes. Unexpectedly we found by mass spectrometry that these enzymes had been modified posttranslationally in vivo by a mechanism-based “suicide” inactivation. A large percentage of the α subunit of each enzyme had been modified in vivo to give peaks with masses m/z = 57 ± 1 and m/z = 75 ± 1 daltons higher than the parent peak. AdoMetDC activity decreased markedly during overexpression concurrently with the increase of the additional peaks for the α subunit. Sequencing of a tryptic fragment by tandem mass spectrometry showed that Cys-140 was modified with a +75 ± 1 adduct, which is probably derived from the reaction product. Comparable modification of the α subunit was also observed in in vitro experiments after incubation with the substrate or with the reaction product, which is consistent with the in vitro alkylation of E. coli AdoMetDC reported by Diaz and Anton [Diaz, E. & Anton, D. L. (1991) Biochemistry 30, 4078–4081]. PMID:11526206

  18. In vivo mechanism-based inactivation of S-adenosylmethionine decarboxylases from Escherichia coli, Salmonella typhimurium, and Saccharomyces cerevisiae.

    PubMed

    Li, Y F; Hess, S; Pannell, L K; White Tabor, C; Tabor, H

    2001-09-11

    S-adenosylmethionine decarboxylase (AdoMetDC), a key enzyme in the biosynthesis of spermidine and spermine, is first synthesized as a proenzyme, which is cleaved posttranslationally to form alpha and beta subunits. The alpha subunit contains a covalently bound pyruvoyl group derived from serine that is essential for activity. With the use of an Escherichia coli overexpression system, we have purified AdoMetDCs encoded by the E. coli, Saccharomyces cerevisiae, and Salmonella typhimurium genes. Unexpectedly we found by mass spectrometry that these enzymes had been modified posttranslationally in vivo by a mechanism-based "suicide" inactivation. A large percentage of the alpha subunit of each enzyme had been modified in vivo to give peaks with masses m/z = 57 +/- 1 and m/z = 75 +/- 1 daltons higher than the parent peak. AdoMetDC activity decreased markedly during overexpression concurrently with the increase of the additional peaks for the alpha subunit. Sequencing of a tryptic fragment by tandem mass spectrometry showed that Cys-140 was modified with a +75 +/- 1 adduct, which is probably derived from the reaction product. Comparable modification of the alpha subunit was also observed in in vitro experiments after incubation with the substrate or with the reaction product, which is consistent with the in vitro alkylation of E. coli AdoMetDC reported by Diaz and Anton [Diaz, E. & Anton, D. L. (1991) Biochemistry 30, 4078-4081].

  19. The effect of photo-activated glazes on the microhardness of acrylic baseplate resins.

    PubMed

    Emmanouil, J K; Kavouras, P; Kehagias, Th

    2002-01-01

    A comparative investigation of acrylic denture base surface microhardness, induced through glazing with different photo-activated liquids. Thermopolymerized acrylic resin Paladon 65 (Kulzer) was used for this study. The samples were mechanically thinned by silicon carbide grinding papers and finally, mechanically polished by alumina pastes. The samples were then glazed with Palaseal, Plaquit and Lightplast-Lack photo-activated liquids. Microhardness tests were carried out via a Zeiss optical microscope equipped with an Anton Paar microhardness tester fitted with a Knoop indenter. Microhardness testing performed on surfaces glazed by Plaquit, Lightplast-Lack, and Palaseal photo-activated liquids showed enhanced microhardness values compared to the mechanically polished acrylic resin denture base material. Comparative microhardness tests performed on acrylic base resin treated with photo-activated acrylic glazes showed that all increases the surface microhardness. The enhancement of surface microhardness of acrylic denture bases suggests that they are likely to resist wear during service.

  20. jsc2017e138127 - At the Baikonur Cosmodrome in Kazakhstan, the Expedition 54-55 prime and backup crewmembers pose for pictures Dec. 13 in front of the cottage where the iconic Russian space designer Sergey Korolev slept on the night before Yuri Gagarin la

    2017-12-13

    jsc2017e138127 - At the Baikonur Cosmodrome in Kazakhstan, the Expedition 54-55 prime and backup crewmembers pose for pictures Dec. 13 in front of the cottage where the iconic Russian space designer Sergey Korolev slept on the night before Yuri Gagarin launched April 12, 1961 to become the first human to fly in space. Korolev’s cottage is next to the cottage where Gagarin slept on the eve of his launch. From left to right are backup crewmembers Alexander Gerst of the European Space Agency, Sergey Prokopyev of the Russian Federal Space Agency (Roscosmos) and Jeanette Epps of NASA, and prime crewmembers Scott Tingle of NASA, Anton Shkaplerov of Roscosmos and Norishige Kanai of the Japan Aerospace Exploration Agency. Tingle, Kanai and Shkaplerov will launch Dec. 17 on the Soyuz MS-07 spacecraft for a five month mission on the International Space Station...Andrey Shelepin/Gagarin Cosmonaut Training Center.

  1. jsc2014e049621

    2014-05-21

    11-47-48: At the Cosmonaut Hotel crew quarters in Baikonur, Kazakhstan, Expedition 40/41 backup crewmembers Terry Virts of NASA (left) and Samantha Cristoforetti of the European Space Agency (right) try their hand at a game of billiards May 21 as they head into the homestretch of pre-launch training. Virts, Cristoforetti and Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) are backing up the prime crew, Flight Engineer Alexander Gerst of the European Space Agency, Soyuz Commander Max Suraev of Roscosmos and NASA Flight Engineer Reid Wiseman, who will launch on May 29, Kazakh time, on the Soyuz TMA-13M spacecraft from the Baikonur Cosmodrome for a 5 ½ month mission on the International Space Station. NASA/Victor Zelentsov

  2. The New Physics and Cosmology - Dialogues with the Dalai Lama

    NASA Astrophysics Data System (ADS)

    Zajonc, Arthur; Houshmand, Zara

    2004-03-01

    What happens when the Dalai Lama meets with leading physicists and a historian? This book is the carefully edited record of the fascinating discussions at a Mind and Life conference in which five leading physicists and a historian (David Finkelstein, George Greenstein, Piet Hut, Arthur Zajonc, Anton Zeilinger, and Tu Weiming) discussed with the Dalai Lama current thought in theoretical quantum physics, in the context of Buddhist philosophy. A contribution to the science-religion interface, and a useful explanation of our basic understanding of quantum reality, couched at a level that intelligent readers without a deep involvement in science can grasp. In the tradition of other popular books on resonances between modern quantum physics and Zen or Buddhist mystical traditions--notably The Dancing Wu Li Masters and The Tao of Physics , this book gives a clear and useful update of the genuine correspondences between these two rather disparate approaches to understanding the nature of reality.

  3. Corporeal elements and principles in the learned German chymical tradition.

    PubMed

    Klein, Joel A

    2014-11-01

    This paper explores diverse conceptions of the physicality and tangibility of elements and principles in early modern chymistry. By tracing the development of natural philosophical and corpuscular ideas about material elements and principles among several physicans and chymists, including Thomas Erastus, Andreas Libavius, Daniel Sennert, and Anton Günther Billich, this article locates a learned tradition that developed predominantly in Germany, and which directly challenged a common understanding of matter held by major Paracelsians as well as authors from the French textbook tradition. Likewise, conceptions of incorporeal elements or principles are shown to have developed from the ideas of Paracelsus and Petrus Severinus, whereas authors in the learned tradition emphasised a particular interpretation of Aristotle. The article concludes by suggesting that chymical interpretations of material composition had an important influence throughout the seventeenth and eighteenth centuries, and that this provides further evidence that the so-called "compositional revolution" in chemistry was well underway prior to the eighteenth century.

  4. Bell's palsy before Bell: Cornelis Stalpart van der Wiel's observation of Bell's palsy in 1683.

    PubMed

    van de Graaf, Robert C; Nicolai, Jean-Philippe A

    2005-11-01

    Bell's palsy is named after Sir Charles Bell (1774-1842), who has long been considered to be the first to describe idiopathic facial paralysis in the early 19th century. However, it was discovered that Nicolaus Anton Friedreich (1761-1836) and James Douglas (1675-1742) preceded him in the 18th century. Recently, an even earlier account of Bell's palsy was found, as observed by Cornelis Stalpart van der Wiel (1620-1702) from The Hague, The Netherlands in 1683. Because our current knowledge of the history of Bell's palsy before Bell is limited to a few documents, it is interesting to discuss Stalpart van der Wiel's description and determine its additional value for the history of Bell's palsy. It is concluded that Cornelis Stalpart van der Wiel was the first to record Bell's palsy in 1683. His manuscript provides clues for future historical research.

  5. Seafloor Soil Sampling and Geotechnical Parameter Determination - Handbook

    DTIC Science & Technology

    1979-08-01

    Ko + Au(I- Ko )] (7-1) 97 I where ;v = effective overburden pressure (Section 6.1.3) K 0 = coefficient of lateral earLh pressure AU = reference pore...sin i+(6/a Vcos i su [ Ko i 0 V(7-2) a 1 + (2 A -1) sin 4 Vf 99 to oiU - ~1 where ; = overburden pressure ot depth where strength, Su, is to be...Rickivdo ANtON TfIW)I* SKO 11"will NY tIAltA. JOh I~ 11 Acwtx. CO IIRAI Ir/ IA M6I~. CA IIKOWN. RODEIRT Unoily. At. IIUILOCK 1.3 Ju4 I.AYri3X lt,! WA WM TA IIIf O~mc CA 128

  6. Quotable physics

    NASA Astrophysics Data System (ADS)

    Chomet, Seweryn

    2008-03-01

    Anton Capri is an alumnus of Princeton University, where he specialized in quantum field theory, and, since 1998, has been a distinguished professor emeritus at the University of Alberta in Canada. Since his nominal retirement he has devoted much of his time to writing and has now published, among other things, two linked books that present a variety of anecdotes involving famous physicists, as well as useful biographical sketches of them. The origin of these books is clearly defined by their author. "I have not any pretensions to having produced a 'scholarly' work," he writes. "Some of the stories recorded here are gossip, or physics folklore. I have tried to verify as many of the stories as I could, but I have not hesitated to include all stories that I heard and noted down."

  7. Expedition 30 crewmembers look at crew procedures in the SM

    2012-03-24

    ISS030-E-173973 (24 March 2012) --- NASA astronaut Dan Burbank (second left), Expedition 30 commander; along with Russian cosmonauts Oleg Kononenko (left) and Anton Shkaplerov and NASA astronaut Don Pettit, all flight engineers, are pictured in the Zvezda Service Module of the International Space Station as they prepare to move to the appropriate Soyuz vehicles, due to the possibility that space debris could pass close to the station. Burbank, Shkaplerov and Ivanishin sheltered in the Soyuz TMA-22 spacecraft attached to the Poisk Mini-Research Module 2 (MRM2) while Kononenko, Kuipers and Pettit took to the Soyuz TMA-03M docked to the Rassvet Mini-Research Module 1 (MRM-1).

  8. [The original German scholarly literature of medieval falconry and the history of its scientific research].

    PubMed

    Giese, Martina

    2007-01-01

    German scholarly literature (Fachliteratur) of the middle ages devoted to falconry falls into two main categories: Translations, mostly of latin works, and original treatises. After a short survey of falconry in the past, this article will discuss the original treatises and the history of their analysis since the 19th century. In this context it will deal with the research of the following scholars: Joseph von Hammer-Purgstall, Anton von Perger, Ernst von Dombrowski, Hermann Werth, Christoph von Biedermann and--most importantly--Kurt Lindner. The appendix contains the editio princeps of the German Münchener Rezeptar I from the codex unicus, München, Universitätsbibliothek, 80 Cod. ms. 354, fol. 31r-33r (dating from the 15th century).

  9. Proceedings of the Conference on the Design of Experiments in Army Research Development and Testing (20th). Held at Army Operational Test and Evaluation Agency and Army Engineer Center at Fort Belvoir, VA., on 23-25 October 1974. Part 1

    DTIC Science & Technology

    1975-06-01

    Anton Hauschild, Manufactur ing Technology D i r e c t o r a t e , Frankford Arsonal , P h i l a d e l p h i a , Pennsy lvania RATE DEPENDENT...Bethesda, Mary land OBSERVAT I ONS ON THE ALGEBRA OF NON-N0R;IAL FUNCT 1 ONS Donald M, Neal, Mechanics Research Laboratory, A r m y M a t e r i a l...a r a c t e r i s t i c func t ions i n combination wi th elementary m a t r i x a l g e b r a , he demonstrated t h e independence of I I v

  10. A review of the Magnus effect in aeronautics

    NASA Astrophysics Data System (ADS)

    Seifert, Jost

    2012-11-01

    The Magnus effect is well-known for its influence on the flight path of a spinning ball. Besides ball games, the method of producing a lift force by spinning a body of revolution in cross-flow was not used in any kind of commercial application until the year 1924, when Anton Flettner invented and built the first rotor ship Buckau. This sailboat extracted its propulsive force from the airflow around two large rotating cylinders. It attracted attention wherever it was presented to the public and inspired scientists and engineers to use a rotating cylinder as a lifting device for aircraft. This article reviews the application of Magnus effect devices and concepts in aeronautics that have been investigated by various researchers and concludes with discussions on future challenges in their application.

  11. Partial Molar Volumes of 15-Crown-5 Ether in Mixtures of N,N-Dimethylformamide with Water.

    PubMed

    Tyczyńska, Magdalena; Jóźwiak, Małgorzata

    2014-01-01

    The density of 15-crown-5 ether (15C5) solutions in the mixtures of N,N -dimethylformamide (DMF) and water (H 2 O) was measured within the temperature range 293.15-308.15 K using an Anton Paar oscillatory U-tube densimeter. The results were used to calculate the apparent molar volumes ( V Φ ) of 15C5 in the mixtures of DMF + H 2 O over the whole concentration range. Using the apparent molar volumes and Redlich and Mayer equation, the standard partial molar volumes of 15-crown-5 were calculated at infinite dilution ([Formula: see text]). The limiting apparent molar expansibilities ( α ) were also calculated. The data are discussed from the point of view of the effect of concentration changes on interactions in solution.

  12. Performance of magnetorheological elastomer based green epoxidized natural rubber/sucrose acetate isobutyrate hybrid matrix

    NASA Astrophysics Data System (ADS)

    Khairi, Muntaz Hana Ahmad; Amri Mazlan, Saiful; Aziz, Siti Aishah Abdul; Ubaidillah; Tan Shilan, Salihah

    2018-04-01

    This study introduces a sucrose acetate isobutyrate (SAIB) as a novel additive of magnetorheological elastomers (MREs). The MREs utilized an epoxidized natural rubber (ENR) as the matrix and carbonyl iron particles (CIPs) as their filler. The CIPs were fixed at 60 wt%. The viscosity of the compound was observed using a viscometer. Meanwhile, the microstructures were observed by using field emission scanning electron microscope (FESEM). Rheological properties regarding shear storage modulus were measured by using a rheometer (MCR 302, Anton Paar). The experimental results demonstrated that the MREs-based ENR/SAIB had a decrement in their viscosity by 40% reduction. Moreover, the magnetorheological (MR) effect increased by 23% as the increment of magnetic fields. The morphological photograph showed that the CIPs embedded well within the matrix. The fabricated MREs samples were strain dependent, where all MREs samples exhibit the deteriorating trend when increasing the strain amplitude.

  13. Expedition_55_Post_Landing_Activities_June_4_2018_661449

    2018-06-04

    Expedition 55 Crew Receives a Warm Welcome in Kazakhstan-------- Expedition 55 Commander Anton Shkaplerov of Roscosmos and Flight Engineers Scott Tingle of NASA and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) were greeted in a traditional ceremony at the airport in Karaganda, Kazakhstan June 3, a few hours after landing in their Soyuz MS-07 spacecraft in Kazakhstan near the town of Dzhezkazgan. After the ceremony, the crew split up, with Shkaplerov returning to his training base in Star City, Russia, while Tingle and Kanai flew back to their homes in Houston on a NASA jet. The trio spent almost six months in space. The footage includes interviews with Tingle at the Karaganda airport.

  14. [A nosology for supernatural phenomena and the construction of the 'possessed' brain in the nineteenth century].

    PubMed

    Goncalves, Valeria Portugal; Ortega, Francisco

    2013-06-01

    At the end of the twentieth century, supernatural phenomena such as so called trances and possession by spirits received a scientific classification, which includes the numerous diagnoses of the dominant psychiatry. At the end of the nineteenth century we can observe a process of scientific categorization of phenomena considered to have originated in superstition or popular imagination. In this work we show how trances and spiritual possession were studied by Franz Anton Mesmer and his followers when developing the concept of magnetism; by James Braid during the creation of his theory of hypnosis; and by Jean Martin Charcot, which marked the entry of hysteria into nosological classification. Despite the differences between these schools, we identify the use of the brain and cerebral metaphors as the foundation of theories of the mind.

  15. jsc2014e045101

    2014-05-15

    1535: With the statue of Vladimir Lenin in the background at the Gagarin Cosmonaut Training Center in Star City, Russia, the Expedition 40/41 prime and backup crewmembers pose for pictures May 15 prior to their departure for the Baikonur Cosmodrome in Kazakhstan for final pre-launch training. From left to right are backup crewmembers Terry Virts of NASA, Anton Shkaplerov of the Russian Federal Space Agency (Roscosmos) and Samantha Cristoforetti of the European Space Agency, and prime crewmembers Alexander Gerst of the European Space Agency, Soyuz Commander Max Suraev of Roscosmos and Reid Wiseman of NASA. Wiseman, Suraev and Gerst will launch on May 29, Kazakh time, in the Soyuz TMA-13M spacecraft from Baikonur for a 5 ½ month mission on the International Space Station. NASA/Stephanie Stoll

  16. On the history of dissociative identity disorders in Germany: the doctor Justinus Kerner and the girl from Orlach, or possession as an "exchange of the self".

    PubMed

    Peter, Burkhard

    2011-01-01

    The history of hypnosis is closely linked to the theme of possession; one such link is that the forerunner of hypnosis, animal magnetism, replaced exorcism in 1775 when Franz Anton Mesmer testified against Father Johann Joseph Gassner's exorcism. Modern authors have noted remarkable similarities between states of possession and dissociation. The treatment of possession by animal magnetism and exorcism represents the special romantic-magnetic therapy of the German medical doctor Justinus Kerner in the early 19th century. This article describes the man, his methods, and his thinking and presents one of his most famous case studies, the girl from Orlach, which, by today's standards, was a true case of dissociative identity disorder (DID). This article describes how contemporary principles of treatment were used and controversial issues about the nature and causes of DID were discussed 175 years ago.

  17. Expedition 55 Soyuz Docking

    2018-03-24

    Expedition 55 flight engineer Ricky Arnold of NASA is seen after the hatches were opened between the Soyuz MS-08 spacecraft and the International Space Station on screens at the Moscow Mission Control Center in Korolev, Russia, Saturday, March 24, 2018, a few hours after the Soyuz MS-08 docked to the International Space Station. Hatches were opened at 5:48 p.m. Eastern time on March 23 (12:48 a.m. Moscow time on March 24) and Arnold, Oleg Artemyev of Roscosmos, and Drew Feustel of NASA joined Expedition 55 Commander Anton Shkaplerov of Roscosmos, Scott Tingle of NASA, and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) onboard the orbiting laboratory. Photo Credit: (NASA/Joel Kowsky)

  18. Expedition 55 Soyuz Docking

    2018-03-23

    Guests watch a live view of the International Space Station, as seen by cameras onboard the Soyuz MS-08 spacecraft with Expedition 55-56 crewmembers Oleg Artemyev of Roscosmos and Ricky Arnold and Drew Feustel of NASA, on screens at the Moscow Mission Control Center as the spacecraft approaches for docking, Friday, March 23, 2018 in Korolev, Russia. The Soyuz MS-08 spacecraft carrying Artemyev, Feustel, and Arnold docked at 3:40 p.m. Eastern time (10:40 p.m. Moscow time) and joined Expedition 55 Commander Anton Shkaplerov of Roscosmos, Scott Tingle of NASA, and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA). Photo Credit: (NASA/Joel Kowsky)

  19. Expedition 55 Soyuz Docking

    2018-03-23

    A live view of the International Space Station, as seen by cameras onboard the Soyuz MS-08 spacecraft with Expedition 55-56 crewmembers Oleg Artemyev of Roscosmos and Ricky Arnold and Drew Feustel of NASA, is seen on screens at the Moscow Mission Control Center as the spacecraft approaches for docking, Friday, March 23, 2018 in Korolev, Russia. The Soyuz MS-08 spacecraft carrying Artemyev, Feustel, and Arnold docked at 3:40 p.m. Eastern time (10:40 p.m. Moscow time) and joined Expedition 55 Commander Anton Shkaplerov of Roscosmos, Scott Tingle of NASA, and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA). Photo Credit: (NASA/Joel Kowsky)

  20. Expedition 54 Soyuz Docking

    2017-12-19

    Icons for the International Space Station and Soyuz MS-07 spacecraft are seen on a tracking map on a screen in the Moscow Mission Control Center as the spacecraft approaches for docking, Tuesday, Dec. 19, 2017 in Korolev, Russia. The Soyuz MS-07 spacecraft carrying Anton Shkaplerov of Roscosmos, Scott Tingle of NASA, and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) docked with the International Space Station at 3:39 a.m. EST, Tuesday, Dec. 19 while 250 statute miles over the southern coast of Italy and joined Expedition 54 Commander Alexander Misurkin of Roscosmos, and NASA astronauts Joe Acaba and Mark Vande Hei. Photo Credit: (NASA/Joel Kowsky)

  1. Expedition 55 Soyuz Docking

    2018-03-24

    Expedition 55 flight engineer Drew Feustel of NASA is seen after the hatches were opened between the Soyuz MS-08 spacecraft and the International Space Station on screens at the Moscow Mission Control Center in Korolev, Russia, Saturday, March 24, 2018, a few hours after the Soyuz MS-08 docked to the International Space Station. Hatches were opened at 5:48 p.m. Eastern time on March 23 (12:48 a.m. Moscow time on March 24) and Feustel, Oleg Artemyev of Roscosmos, and Ricky Arnold of NASA joined Expedition 55 Commander Anton Shkaplerov of Roscosmos, Scott Tingle of NASA, and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) onboard the orbiting laboratory. Photo Credit: (NASA/Joel Kowsky)

  2. Expedition 54 Soyuz Docking

    2017-12-19

    Scott Tingle of NASA is seen embracing Expedition 54 Commander Alexander Misurkin after the opening of the hatches between the Soyuz MS-07 spacecraft and the International Space Station on the screens in the Moscow Mission Control Center in Korolev, Russia a few hours after the Soyuz MS-07 docked to the International Space Station on Tuesday, Dec. 19, 2017. Hatches were opened at 5:55 a.m. EST and Tingle, Anton Shkaplerov of Roscosmos, and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA) joined Expedition 54 Commander Alexander Misurkin of Roscosmos and crewmates Mark Vande Hei and Joe Acaba of NASA aboard the orbiting laboratory. Photo Credit: (NASA/Joel Kowsky)

  3. jsc2017e136057 - On a snowy night at Red Square Moscow, Expedition 54-55 backup crewmembers Sergey Prokopyev of the Russian Federal Space Agency (Roscosmos, left), Jeanette Epps of NASA (center) and Alexander Gerst of the European Space Agency (right) pay

    2017-11-30

    jsc2017e136057 - On a snowy night at Red Square Moscow, Expedition 54-55 backup crewmembers Sergey Prokopyev of the Russian Federal Space Agency (Roscosmos, left), Jeanette Epps of NASA (center) and Alexander Gerst of the European Space Agency (right) pay homage at the Kremlin Wall where Russian space icons are interred in traditional pre-launch ceremonies Nov. 30. They are backups to Anton Shkaplerov of Roscosmos, Scott Tingle of NASA and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA), who will launch from the Baikonur Cosmodrome in Kazakhstan on the Soyuz MS-07 spacecraft Dec. 17 for a five-month mission on the International Space Station...Andrey Shelepin/Gagarin Cosmonaut Training Center.

  4. jsc2017e136055 - On a snowy night at Red Square in Moscow, Expedition 54-55 backup crewmember Jeanette Epps of NASA lays flowers at the Kremlin Wall where Russian space icons are interred in traditional pre-launch ceremonies Nov. 30. Looking on are backup

    2017-11-30

    jsc2017e136055 - On a snowy night at Red Square in Moscow, Expedition 54-55 backup crewmember Jeanette Epps of NASA lays flowers at the Kremlin Wall where Russian space icons are interred in traditional pre-launch ceremonies Nov. 30. Looking on are backup crewmembers Sergey Prokopyev of the Russian Federal Space Agency (Roscosmos, left) and Alexander Gerst of the European Space Agency. They are backups to Anton Shkaplerov of Roscosmos, Scott Tingle of NASA and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA), who will launch from the Baikonur Cosmodrome in Kazakhstan on the Soyuz MS-07 spacecraft Dec. 17 for a five-month mission on the International Space Station...Andrey Shelepin/Gagarin Cosmonaut Training Center.

  5. E54-55 Change of Command Ceremony_622857_hires

    2018-02-27

    Expedition 54 Crew Hands Over the Space Station to Expedition 55---- The reins of the International Space Station were passed from Alexander Misurkin of Roscosmos to his cosmonaut crewmate Anton Shkaplerov during a ceremony on the orbital laboratory on Feb. 26. Misurkin is returning to Earth with his Expedition 54 crewmates, Mark Vande Hei and Joe Acaba of NASA, in the Soyuz MS-06 spacecraft. They will land on the steppe of Kazakhstan Feb. 28 (Feb. 27, U.S. time) to complete a five-and-a-half-month mission. Shkaplerov remains on the station as commander of Expedition 55 along with Flight Engineers Scott Tingle of NASA and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA).

  6. The New Physics

    NASA Astrophysics Data System (ADS)

    Fraser, Gordon

    2006-04-01

    Introduction Gordon Fraser; Part I. Matter and the Universe: 1. Cosmology Wendy Freedman and Rocky Kolb; 2. Gravity Ronald Adler; 3. Astrophysics Arnon Dar; 4. Particles and the standard model Chris Quigg; 5. Superstrings Michael Green; Part II. Quantum Matter: 6. Atoms and photons Claude Cohen-Tannoudji and Jean Dalibard; 7. The quantum world of ultra-cold atoms Christopher Foot and William Phillips; 8. Superfluidity Henry Hall; 9. Quantum phase transitions Subir Sachdev; Part III. Quanta in Action: 10. Quantum entanglement Anton Zeilinger; 11. Quanta, ciphers and computers Artur Ekert; 12. Small-scale structure and nanoscience Yoseph Imry; Part IV. Calculation and Computation: 13. Nonlinearity Henry Abarbanel; 14. Complexity Antonio Politi; 15. Collaborative physics, e-science and the grid Tony Hey and Anne Trefethen; Part V. Science in Action: 16. Biophysics Cyrus Safinya; 17. Medical physics Nicolaj Pavel; 18. Physics and materials Robert Cahn; 19. Physics and society Ugo Amaldi.

  7. The New Physics

    NASA Astrophysics Data System (ADS)

    Fraser, Gordon

    2009-08-01

    Introduction Gordon Fraser; Part I. Matter and the Universe: 1. Cosmology Wendy Freedman and Rocky Kolb; 2. Gravity Ronald Adler; 3. Astrophysics Arnon Dar; 4. Particles and the standard model Chris Quigg; 5. Superstrings Michael Green; Part II. Quantum Matter: 6. Atoms and photons Claude Cohen-Tannoudji and Jean Dalibard; 7. The quantum world of ultra-cold atoms Christopher Foot and William Phillips; 8. Superfluidity Henry Hall; 9. Quantum phase transitions Subir Sachdev; Part III. Quanta in Action: 10. Quantum entanglement Anton Zeilinger; 11. Quanta, ciphers and computers Artur Ekert; 12. Small-scale structure and nanoscience Yoseph Imry; Part IV. Calculation and Computation: 13. Nonlinearity Henry Abarbanel; 14. Complexity Antonio Politi; 15. Collaborative physics, e-science and the grid Tony Hey and Anne Trefethen; Part V. Science in Action: 16. Biophysics Cyrus Safinya; 17. Medical physics Nicolaj Pavel; 18. Physics and materials Robert Cahn; 19. Physics and society Ugo Amaldi.

  8. "Franklin: Science, Politics and France"

    NASA Astrophysics Data System (ADS)

    McClellan, James E., III

    2003-04-01

    This presentation traces Benjamin Franklin's career as a "civic scientist" in Old-Regime France. It outlines the initial - and not always positive - reception of Franklin's work on electricity by the community of French scientists in the 1750s. It sketches Franklin's subsequent elevation into the pantheon of French Enlightenment heros, and it details his work as a "civic scientist" while American envoy to France in the 1770s and 1780s, notably his service on the government-sponsored commissions that repudiated the scientific and medical claims of Franz Anton Mesmer. This presentation concludes by examining a few features of Franklin's career that are not completely congruent with our notion of what a "civic scientist" might be, a contrast that is intended to illuminate both Franklin and the concept of "civic scientist."

  9. The power of a musical instrument: Franklin, the Mozarts, Mesmer, and the glass armonica.

    PubMed

    Gallo, D A; Finger, S

    2000-11-01

    In 1761 Benjamin Franklin invented the armonica (often referred to as the glass harmonica), an instrument designed to simplify the playing of the musical glasses. The instrument immediately became popular and inspired compositions by Wolfgang Mozart, who had the opportunity to hear and play one at the house of Franz Anton Mesmer. Armonica music was used by Mesmer in his séances, because he felt it could promote healing by propagating a mystical fluid that he called animal magnetism through the body. After Mesmer's theories were debunked by a highly respected panel of scientists, the armonica fell out of vogue. Because Franklin was on the panel that examined the discredited mesmerism, he indirectly contributed to his own invention's demise.

  10. Serologic evidence of human Rickettsia infection found in three locations in Panamá.

    PubMed

    Bermúdez, Sergio E; Lyons, Cirilo R; García, Gleydis G; Zaldíva, Yamitzel L; Gabster, Amanda; Arteaga, Griselda B

    2013-09-01

    Since the middle of last century, cases of rickettsiosis have been found in Panamá when outbreaks of murine typhus and spotted fever were reported. Since then, little information exists about its prevalence in this country, since it is most often is misdiagnosed as another disease. The aim of this paper is to demonstrate the presence of Rickettsia infections in humans in three locations in Panamá. These locations are agricultural areas, near forested areas or those who work in zoo. Three locations where chosen for this study: Tortí, El Valle de Antón and workers in the Summit Municipal Park in Panamá City. All volunteers signed an informed consent and answered a questionnaire. The samples were analyzed for the detection of rickettsial spotted fever and typhus group by the indirect immunofluorescence (using commercial kits) and antigens of Rickettsia rickettsii and R. amblyommii. Blood samples were taken from 97 volunteers in Tortí (25), El Valle de Anton (37) and Summit Municipal Park (35). Of these, a total of 38 (39%) samples reacted to one of the two methods: eight (32%) in Tortí, 18 (48%) in El valle and 12 (34%) in Summit Municipal Park. The results show a high prevalence of antibodies to Rickettsia belonging to the spotted fever group in each of the three study areas, in addition to presenting evidence of the typhus group Rickettsia in El Valle de Anton. These areas could be considered endemic for rickettsiosis as there are conditions for maintaining them.

  11. Convergence and reproducibility in molecular dynamics simulations of the DNA duplex d(GCACGAACGAACGAACGC)

    PubMed Central

    Galindo-Murillo, Rodrigo; Roe, Daniel R.; Cheatham, Thomas E.

    2014-01-01

    Background The structure and dynamics of DNA are critically related to its function. Molecular dynamics (MD) simulations augment experiment by providing detailed information about the atomic motions. However, to date the simulations have not been long enough for convergence of the dynamics and structural properties of DNA. Methods MD simulations performed with AMBER using the ff99SB force field with the parmbsc0 modifications, including ensembles of independent simulations, were compared to long timescale MD performed with the specialized Anton MD engine on the B-DNA structure d(GCACGAACGAACGAACGC). To assess convergence, the decay of the average RMSD values over longer and longer time intervals was evaluated in addition to assessing convergence of the dynamics via the Kullback-Leibler divergence of principal component projection histograms. Results These MD simulations —including one of the longest simulations of DNA published to date at ~44 μs—surprisingly suggest that the structure and dynamics of the DNA helix, neglecting the terminal base pairs, are essentially fully converged on the ~1–5 μs timescale. Conclusions We can now reproducibly converge the structure and dynamics of B-DNA helices, omitting the terminal base pairs, on the μs time scale with both the AMBER and CHARMM C36 nucleic acid force fields. Results from independent ensembles of simulations starting from different initial conditions, when aggregated, match the results from long timescale simulations on the specialized Anton MD engine. General Significance With access to large-scale GPU resources or the specialized MD engine “Anton” it is possibly for a variety of molecular systems to reproducibly and reliably converge the conformational ensemble of sampled structures. PMID:25219455

  12. The speEspeD operon of Escherichia coli. Formation and processing of a proenzyme form of S-adenosylmethionine decarboxylase.

    PubMed

    Tabor, C W; Tabor, H

    1987-11-25

    We have previously shown that the gene (speD) for S-adenosylmethionine decarboxylase is part of an operon that also contains the gene (speE) for spermidine synthase (Tabor, C. W., Tabor, H., and Xie, Q.-W. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 6040-6044). We have now determined the nucleotide sequence of this operon and have found that speD codes for a polypeptide of Mr = 30,400, which is considerably greater than the subunit size of the purified enzyme. Our studies show that S-adenosylmethionine decarboxylase is first formed as a Mr = 30,400 polypeptide and that this proenzyme is then cleaved at the Lys111-Ser112 peptide bond to form a Mr = 12,400 subunit and a Mr = 18,000 subunit. The latter subunit contains the pyruvoyl moiety that we previously showed is required for enzymatic activity. Both subunits are present in the purified enzyme. These conclusions are based on (i) pulse-chase experiments with a strain containing a speD+ plasmid which showed a precursor-product relationship between the proenzyme and the enzyme subunits, (ii) the amino acid sequence of the proenzyme form of S-adenosylmethionine decarboxylase (derived from the nucleotide sequence of the speD gene), and (iii) comparison of this sequence of the proenzyme with the N-terminal amino acid sequences of the two subunits of the purified enzyme reported by Anton and Kutny (Anton, D. L., and Kutny, R. (1987) J. Biol. Chem. 262, 2817-2822).

  13. Impact of craving on alcohol relapse during, and 12 months following, outpatient treatment.

    PubMed

    Bottlender, Miriam; Soyka, Michael

    2004-01-01

    This study investigated the relationship between craving in abstinent alcohol-dependent patients measured by the Obsessive Compulsive Craving Scale (OCDS) (Anton et al., 1995) and relapse during and after completion of an intensive outpatient treatment programme. In a prospective study, participants were interviewed at entry to, and end of, an outpatient treatment programme, and 12 months after the end of the programme. To measuring craving the OCDS total score by Anton et al. (1995) and the three-factor model by Kranzler et al. (1999) were used. OCDS was administered at the beginning of treatment (when all patients were abstinent), and at the end of treatment in those who were abstinent and had completed the programme. Of 103 alcohol-dependent patients, 74 completed the treatment programme and at follow-up after 12 months 97% of these patients were personally re-interviewed. Thirty-two patients (31%) relapsed during the treatment phase. They had significantly higher craving measured by the total OCDS score and a significantly higher score on the subscales 'obsessions' and 'drinking control and consequences' compared to abstinent patients. Of the 74 patients who completed the programme 16% had a major relapse in the next 12 months. Major relapse was predicted by the total OCDS score and the subscale 'obsessions'. OCDS total score predicts relapse in outpatient treatment. Treatment and aftercare of patients with high craving should be intensified. In our study design, the subscales of the three-factor model by Kranzler et al. (1999) provided only little information gain compared to the OCDS total score.

  14. Mapping the isotopic signature of methane in South-Eastern Spain: complementing biogeochemical long-term research with short term observations

    NASA Astrophysics Data System (ADS)

    Àgueda, Alba; Morguí, Josep Anton; Vazquez Garcia, Eusebi; Curcoll, Roger; Lowry, David; Fisher, Rebecca E.; Nisbet, Euan G.

    2016-04-01

    will be helpful in the validation of transport models. *Corresponding author: Josep Anton Morguí - josep-anton.morgui@ic3.cat "The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) in the InGOS project under grant agreement n° 284274''

  15. The Zach family in Hungary

    NASA Astrophysics Data System (ADS)

    Vargha, Magda

    The Zach Family moved to Hungary. In the first decades of the 18th century the population was so low in Hungary that thousands of people moved into an almost empty country. In 1740 the physician Joseph Zach (1714-1792) came from Moravia to Esztergom which at that time had only 10 000 inhabitants. Soon he became the city doctor. It is very probable, that this was the place where he met Klara Sonntag, who became his wife. In any case, Zach moved to Pest, where he became the city doctor in 1746. The Invalide-Hospital built by Martinelli in 1726 was the biggest and most elegant house in Pest at that time - and it was giving shelter to 4000 invalids, whilst the city itself had only 11 000 inhabitants. There Zach became the ``protomedicus''. In 1751 Austrian Empress Maria Theresia visited this military hospital. She was so impressed by Zach's work that she honoured him with Hungarian nobility in 1765. From the corresponding official paper we know that he had three sons and three daughters. In 1791 he received citizenship in Pest. The Hungarian Magnates favoured the talented physician. The Lord Chief Justice Count György Fekete was also among his patients. His thirteen year-old son Count János Fekete became the godfather of Zach's son Franz Xaver Zach in 1754. It is very likely that Voltairian Count János Fekete influenced the personality of Franz Xaver von Zach. Galicia became Austrian Territory in 1772. Pater Liesganig was nominated to lead the Land-Survey Office of Galicia. Anton von Zach and Franz Xaver Zach were his co-workers in this very important task. At the same time Franz Zach became a professor of mechanics at Lemberg University and in its observatory he began his life-long astronomical observations. It is very probable that he joined the Freemasons here together with his godfather, now General, Jänos Fekete. Later they stayed in the same cities very often. The military and scientific works of the two Zach brothers Anton and Franz were so highly

  16. Effect of different hardness nanoparticles on friction properties of magnetorheological fluids

    NASA Astrophysics Data System (ADS)

    Zhao, Mingmei; Zhang, Jinqiu; Yao, Jun

    2017-10-01

    Magnetorheological fluids (MRFs) exhibit different wear performance when nanoparticles with different hardness are added. In this study, three solid particles with different hardness are considered to study the variation in MRF performance. The friction and wear properties of the MRF are measured by using a four-ball friction and wear tester, and the surface of the steel ball was observed using a three-dimensional white light interferometer. Also, the rheological properties of MRF are tested by using an Anton-Paar rheometer. The results show that the addition of graphite yields a stable friction process and does not degrade the rheological properties of MRF. Nano-diamond increases the shear yield strength and reduces the wall slip to a greater extent. However, the wear is more serious in this case. Copper particles are unstable, and their surface activity is too high to get adsorbed on the surface of iron powder aggravating the settlement rate. The above three MRFs with different kinds of nano-particles present a more regular grinding spot, and the nano-particles have a certain repair function to the surface.

  17. Investigating everyday measures through exploratory talk: whole class plenary intervention and landscape study at grade four

    NASA Astrophysics Data System (ADS)

    Gade, Sharada; Blomqvist, Charlotta

    2018-03-01

    We report an exploratory talk based, whole class plenary intervention, in relation to students' understanding of everyday measures and measurement, in a grade four classroom at a grade 4-6 school in Sweden. Extended, project related, teacher-researcher collaboration forms basis for such cultural historical activity theory or CHAT based efforts. As formative intervention, the conduct of the plenary is not pre-determined but embedded in ongoing curricular realities, with the agency of students and teacher promoted, pedagogical ideas reutilised and the role of researcher viewed as supporting design and growth of the intervention. Under Charlotta's guidance as teacher, the plenary is opportunity for her students to examine improbable scenarios such as, Can Eva and Anton measure the length of Sweden on foot, Can Lars and Iris measure their age in decimeters. A zone of proximal development is created, in which students make the transition from spontaneous to scientific concepts and learn how various units of measurement are objects-that-can-be-used-for-certain-purposes. With opportunity for critical and reflective inquiry, in a plenary designed to lead development, Charlotta's students look beyond the making of rote measurements and articulate a theory of measure in nascent terms. Such a landscape of teaching-learning is finally understood in terms of the nature of talk that was facilitated, the manner of pedagogy utilised, the style of teaching exercised and the kind of learning that was demanded of her students.

  18. History of Neurosurgery in Palestine.

    PubMed

    Darwazeh, Rami; Darwazeh, Mazhar; Sun, Xiaochuan

    2017-08-01

    Palestinian neurosurgery started with Dr. Antone Tarazi as the first Palestinian neurosurgeon. Before that, there was no organized neurosurgery specialty, and general surgeons performed neurosurgical procedures. Here we review the history of neurosurgery and neurosurgical applications in Palestine, evaluate some limitations of the current system, and discuss major challenges to improving this system. We collected information from various sources in either English or Arabic. The development of neurosurgery and neurosurgical training in Palestine began in 1960 with the first center established in Jerusalem, which provided much-needed neurosurgical services and training in the fields of neurosurgery and neurology. Palestine has produced a number of its own neurosurgeons and has promoted further progress by establishing the Palestinian Neurosurgical Society in 2014. Today, there are 34 neurosurgeons (including 1 female neurosurgeon) and 17 residents providing expert care in 17 centers across Palestine, along with 1 neurosurgical residency program. Neurosurgery in Palestine has faced many challenges, some of which have been overcome. However, there remain many challenges, which will require much time and effort to surmount. Political stabilization is a significant factor in the progress of neurosurgery in Palestine. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. On the history of gout: paleopathological evidence from the Medici family of Florence.

    PubMed

    Giuffra, Valentina; Minozzi, Simona; Vitiello, Angelica; Fornaciari, Antonio

    2017-01-01

    Throughout history, gout has been referred to as the "disease of the kings", and has been clearly associated with the lifestyle of the aristocratic social classes. According to the written sources, several members of the famous Medici family of Florence suffered from an arthritic disease that contemporary physicians called "gout". A paleopathological study carried out on the skeletal remains of some members of the family, exhumed from their tombs in the Church of San Lorenzo in Florence, offered a unique opportunity to directly investigate the evidence of the arthritic diseases affecting this elite group. The skeletal remains of several members of the family were examined macroscopically and submitted to x-ray investigation. The results of the study allowed us to ascertain that the so-called "gout of the Medici" should be considered the clinical manifestation of three different joint conditions: diffuse idiopathic skeletal hyperostosis, rheumatoid arthritis and uratic gout. In particular, uric acid gout was diagnosed in the Grand Duke Ferdinand I (1549-1609). Recently, a new case of this disease was diagnosed in Anton Francesco Maria (1618-1659), a probable illegitimate member of the family. With this new case, uratic gout was observed in 2 out of 9 adult males, leading to suppose that the disease should have been a common health problem within the family. The aetiology of the disease has to be searched in environmental factors, since both historical and paleonutritional studies demonstrated that the diet of this aristocratic court was rich in meat and wine.

  20. Accelerated molecular dynamics simulations of protein folding.

    PubMed

    Miao, Yinglong; Feixas, Ferran; Eun, Changsun; McCammon, J Andrew

    2015-07-30

    Folding of four fast-folding proteins, including chignolin, Trp-cage, villin headpiece and WW domain, was simulated via accelerated molecular dynamics (aMD). In comparison with hundred-of-microsecond timescale conventional molecular dynamics (cMD) simulations performed on the Anton supercomputer, aMD captured complete folding of the four proteins in significantly shorter simulation time. The folded protein conformations were found within 0.2-2.1 Å of the native NMR or X-ray crystal structures. Free energy profiles calculated through improved reweighting of the aMD simulations using cumulant expansion to the second-order are in good agreement with those obtained from cMD simulations. This allows us to identify distinct conformational states (e.g., unfolded and intermediate) other than the native structure and the protein folding energy barriers. Detailed analysis of protein secondary structures and local key residue interactions provided important insights into the protein folding pathways. Furthermore, the selections of force fields and aMD simulation parameters are discussed in detail. Our work shows usefulness and accuracy of aMD in studying protein folding, providing basic references in using aMD in future protein-folding studies. © 2015 Wiley Periodicals, Inc.

  1. Slide-and-exchange mechanism for rapid and selective transport through the nuclear pore complex.

    PubMed

    Raveh, Barak; Karp, Jerome M; Sparks, Samuel; Dutta, Kaushik; Rout, Michael P; Sali, Andrej; Cowburn, David

    2016-05-03

    Nucleocytoplasmic transport is mediated by the interaction of transport factors (TFs) with disordered phenylalanine-glycine (FG) repeats that fill the central channel of the nuclear pore complex (NPC). However, the mechanism by which TFs rapidly diffuse through multiple FG repeats without compromising NPC selectivity is not yet fully understood. In this study, we build on our recent NMR investigations showing that FG repeats are highly dynamic, flexible, and rapidly exchanging among TF interaction sites. We use unbiased long timescale all-atom simulations on the Anton supercomputer, combined with extensive enhanced sampling simulations and NMR experiments, to characterize the thermodynamic and kinetic properties of FG repeats and their interaction with a model transport factor. Both the simulations and experimental data indicate that FG repeats are highly dynamic random coils, lack intrachain interactions, and exhibit significant entropically driven resistance to spatial confinement. We show that the FG motifs reversibly slide in and out of multiple TF interaction sites, transitioning rapidly between a strongly interacting state and a weakly interacting state, rather than undergoing a much slower transition between strongly interacting and completely noninteracting (unbound) states. In the weakly interacting state, FG motifs can be more easily displaced by other competing FG motifs, providing a simple mechanism for rapid exchange of TF/FG motif contacts during transport. This slide-and-exchange mechanism highlights the direct role of the disorder within FG repeats in nucleocytoplasmic transport, and resolves the apparent conflict between the selectivity and speed of transport.

  2. ["To suffer an ordeal": Some Swedish physicians' struggle during the nineteenth century against unhygienic female dress].

    PubMed

    Nordström, M

    1993-01-01

    Tight-lacing of the female body has been practised at various periods in the history of costume. During the romantic age of the nineteenth century the ideal women had to be pale, weak and often pathologically thin. She was supposed to be of a humble disposition and subservient to her husband (according to the doctrine of subordination). Women laced themselves so tightly that their bodies became deformed, with physical injuries and damage to the internal organs as a consequence. Competition for suitable husbands was keen, since marriage was the only honourable way for a woman to ensure that she would be provided for. It was also in the nineteenth century that doctors were beginning to fight against endemic disease and to argue for a more hygienic way of life. They maintained that women were slaves to fashion and that they dressed in an unhygienic way. Above all, they campaigned against the use of tight-laced corsets. Swedish doctors, such as Anton Nyström, Truls Johan Harterlius and Karolina Widerström headed the fight against the use of laced corsetes, on both medical and social grounds. An improved and "informed" costume was introduced which was meant to allow women greater freedom of movement, thus enabling them to live a more natural life. It was, however, not until 1910 that the tightly-laced corset was abandoned. The conclusion of this is that the history of costume is "the history of absurd follies".

  3. Dancing with chemical formulae of antivirals: A panoramic view (Part 2).

    PubMed

    De Clercq, Erik

    2013-11-15

    In this second part of "Dancing with antivirals as chemical formulae" I will focus on a number of chemical compounds that in the last few years have elicited more than common attraction from a commercial viewpoint: (i) favipiravir (T-705), as it is active against influenza, but also several other RNA viruses; (ii) neuraminidase inhibitors such as zanamivir and oseltamivir; (iii) peramivir and laninamivir octanoate, which might be effective against influenza virus following a single (intravenous or inhalation) administration; (iv) sofosbuvir, the (anticipated) cornerstone for the interferon-free therapy of HCV infections; (v) combinations of DAAs (direct antiviral agents) to achieve, in no time, a sustained virus response (SVR) against HCV infection; (vi) HIV protease inhibitors, the latest and most promising being darunavir; (vii) the integrase inhibitors (INIs) (raltegravir, elvitegravir, dolutegravir), representing a new dimension in the anti-HIV armamentarium; (viii), a new class of helicase primase inhibitors (HPIs) that may exceed acyclovir and the other anti-herpes compounds in both potency and safety; (ix) CMX-001, as the latest of Dr. Antonín Holý's legacy for its activity against poxviruses and CMV infections, and (x) noroviruses for which the ideal antiviral compounds are still awaited for. Copyright © 2013 Elsevier Inc. All rights reserved.

  4. Research on data from the ATLAS experiment at CERN

    SciT

    Purohit, Milind V.

    2015-07-31

    In this report senior investigator Prof. Milind V. Purohit describes research done with data from the ATLAS experiment at CERN. This includes preparing papers on the performance of the CSC detector, searches for SUSY using a new modern ''big data'' technique, and a search for supersymmetry (SUSY) using the "zero leptons razor" (0LRaz) technique. The prediction of the W=Z+jets background processes by the ATLAS simulation prior to the fit is found to be overestimated in the phase space of interest. In all new signal regions presented in this analysis the number of events observed is consistent with the post-fit SMmore » expectations. Assuming R-parity conservation, the limit on the gluino mass exceeds 1150 GeV at 95% confidence level, for an LSP mass smaller than 100 GeV. Other USC personnel who participated in this project during the period of this grant were a graduate student, Anton Kravchenko.« less

  5. Microwave Irradiation on Graphene Dispersed Within Polymeric Matrices

    NASA Astrophysics Data System (ADS)

    Cisneros, Jorge; Yust, Brian; Chipara, Mircea

    Graphene is a two dimensional nanomaterial with high thermal and electric conductivity and Young modulus. These features make graphene an ideal reinforcement for polymeric matrices. However, the mechanical features of polymer-carbon nanostructured composites are limited by the dispersion of the filler and by the delamination or microcracks initiated at the interface between the polymeric matrix and nanofiller. This last weakness can be addressed by improving the interface via chemical and physical methods. Microwave heating of graphite is a very efficient approach if the polymeric matrix does not also have a strong absorption. During the irradiation, the nanofiller is preferentially heated; the local melting of the polymer at the interface improves the interface by filling the microcracks and delaminations. Nanocomposites of polystyrene-poly(ethylene-ran-butylene)-polystyrene loaded by various amounts of graphene ranging from 0 % to 20 % wt. have been prepared by solution mixing using chloroform as solvent. The as obtained nanocomposites have been subjected to microwave irradiation in an Anton Paar Monowave 300 system operating at 75 W, for various irradiation times 5, 10, 15, 30, 45, and 60 minutes. The effect of microwave irradiation has been studied by Raman spectroscopy.

  6. Long-timescale molecular dynamics simulations elucidate the dynamics and kinetics of exposure of the hydrophobic patch in troponin C.

    PubMed

    Lindert, Steffen; Kekenes-Huskey, Peter M; McCammon, J Andrew

    2012-10-17

    Troponin (Tn) is an important regulatory protein in the thin-filament complex of cardiomyocytes. Calcium binding to the troponin C (TnC) subunit causes a change in its dynamics that leads to the transient opening of a hydrophobic patch on TnC's surface, to which a helix of another subunit, troponin I (TnI), binds. This process initiates contraction, making it an important target for studies investigating the detailed molecular processes that underlie contraction. Here we use microsecond-timescale Anton molecular dynamics simulations to investigate the dynamics and kinetics of the opening transition of the TnC hydrophobic patch. Free-energy differences for opening are calculated for wild-type Ca(2+)-bound TnC (∼8 kcal/mol), V44Q Ca(2+)-bound TnC (3.2 kcal/mol), E40A Ca(2+)-bound TnC (∼12 kcal/mol), and wild-type apo TnC (∼20 kcal/mol). These results suggest that the mutations have a profound impact on the frequency with which the hydrophobic patch presents to TnI. In addition, these simulations corroborate that cardiac wild-type TnC does not open on timescales relevant to contraction without calcium being bound. Copyright © 2012 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  7. Three-Dimensional Dynamics of Baroclinic Tides Over a Seamount

    NASA Astrophysics Data System (ADS)

    Vlasenko, Vasiliy; Stashchuk, Nataliya; Nimmo-Smith, W. Alex M.

    2018-02-01

    The Massachusetts Institute of Technology general circulation model is used for the analysis of baroclinic tides over Anton Dohrn Seamount (ADS), in the North Atlantic. The model output is validated against in situ data collected during the 136th cruise of the RRS "James Cook" in May-June 2016. The observational data set includes velocity time series recorded at two moorings as well as temperature, salinity, and velocity profiles collected at 22 hydrological stations. Synthesis of observational and model data enabled the reconstruction of the details of baroclinic tidal dynamics over ADS. It was found that the baroclinic tidal waves are generated in the form of tidal beams radiating from the ADS periphery to its center, focusing tidal energy in a surface layer over the seamount's summit. This energy focusing enhances subsurface water mixing and the local generation of internal waves. The tidal beams interacting with the seasonal pycnocline generate short-scale internal waves radiating from the ADS center. An important ecological outcome from this study concerns the pattern of residual currents generated by tides. The rectified flows over ADS have the form of a pair of dipoles, cyclonic and anticyclonic eddies located at the seamount's periphery. These eddies are potentially an important factor in local larvae dispersion and their escape from ADS.

  8. Prediction, Refinement and Persistency of Transmembrane Helix Dimers in Lipid Bilayers using Implicit and Explicit Solvent/Lipid Representations: Microsecond Molecular Dynamics Simulations of ErbB1/B2 and EphA1

    PubMed Central

    Zhang, Liqun; Sodt, Alexander J.; Venable, Richard M.; Pastor, Richard W.; Buck, Matthias

    2012-01-01

    All-atom simulations are carried out on ErbB1/B2 and EphA1 transmembrane helix dimers in lipid bilayers starting from their solution/DMPC bicelle NMR structures. Over the course of microsecond trajectories, the structures remain in close proximity to the initial configuration and satisfy the great majority of experimental tertiary contact restraints. These results further validate CHARMM protein/lipid force fields and simulation protocols on Anton. Separately, dimer conformations are generated using replica exchange in conjunction with an implicit solvent and lipid representation. The implicit model requires further improvement, and this study investigates whether lengthy all-atom molecular dynamics simulations can alleviate the shortcomings of the initial conditions. The simulations correct many of the deficiencies. For example excessive helix twisting is eliminated over a period of hundreds of nanoseconds. The helix tilt, crossing angles and dimer contacts approximate those of the NMR derived structure, although the detailed contact surface remains off-set for one of two helices in both systems. Hence, even microsecond simulations are not long enough for extensive helix rotations. The alternate structures can be rationalized with reference to interaction motifs and may represent still sought after receptor states that are important in ErbB1/B2 and EphA1 signaling. PMID:23042146

  9. Social aesthetics and the management of addiction.

    PubMed

    Musalek, Michael

    2010-11-01

    One of the main causes of nonadherence is that the goals and forms of addiction treatment are not sufficiently attractive. To study the attractiveness of treatment in clinical practice inevitably means to enter the field of social aesthetics. The call for the implementation of social aesthetics in practice results in a shift of paradigms in the treatment of patients suffering from dependence syndromes. The main themes in the literature covered by the article focus on the role of social aesthetics in medicine in general, as well as on the attractiveness of addiction treatment, in particular. When treatment objectives and programmes become more attractive the result will be reduced drop-out rates, and in turn an increase of treatment effectiveness. Transferring theory of social aesthetics to clinical practice, the Anton Proksch Institute's Orpheus Programme is concerned with opening up spaces and creating atmospheres in which it becomes possible for the individual addicts to realise their possibilities. The challenge in the therapeutic process is not only to recognise the significance of the disorders' pathology but also to find ways out of the imagined impossibilities by opening up new possibilities and uncovering resources of the suffering human.

  10. AIDS and Africa. Introduction.

    PubMed

    Kopelman, Loretta M; van Niekerk, Anton A

    2002-04-01

    Sub-Saharan Africa is the epicenter of the HIV/AIDS epidemic, and in this issue of the Journal, seven authors discuss the moral, social and medical implications of having 70% of those stricken living in this area. Anton A. van Niekerk considers complexities of plague in this region (poverty, denial, poor leadership, illiteracy, women's vulnerability, and disenchantment of intimacy) and the importance of finding responses that empower its people. Solomon Benatar reinforces these issues, but also discusses the role of global politics in sub-Saharan Africa, especially discrimination, imperialism and its exploitation by first world countries. Given the public health crisis, Udo Schüklenk and Richard E. Ashcroft defend compulsory licensing of essential HIV/AIDS medications on consequentialist grounds. Keymanthri Moodley discusses the importance of conducting research and the need to understand a moderate form of communitarianism, also referred to as "ubuntu" or "communalism", to help some Africans understand research as an altruistic endeavour. Godfrey B. Tangwa also defends traditional African values of empathy and ubuntu, discussing how they should be enlisted to fight this pandemic. Loretta M. Kopelman criticizes the tendency among those outside Africa to dismiss the HIV/AIDS pandemic, attributing one source to the ubiquitous and misguided punishment theory of disease. The authors conclude that good solutions must be cooperative ventures among countries within and outside of sub-Saharan Africa with far more support from wealthy countries.

  11. Rheological Properties of Automorphic and Semihydromorphic Cryometamorphic Northern Taiga Soils in Northeastern European Russia (Komi Republic)

    NASA Astrophysics Data System (ADS)

    Kholopov, Yu. V.; Khaidapova, D. D.; Lapteva, E. M.

    2018-04-01

    Soil pastes at the water content corresponding to the maximum swelling of samples from different genetic horizons of cryometamorphic soils―surface-gleyic iron-illuvial svetlozem (Folic Albic Stagnosol) and peaty and peat humus-impregnated gleyic svetlozems (Histic Gleyic Stagnosols)―have been studied with an MCR-302 modular rheometer (Anton Paar, Austria). It has been found that the strongest interparticle bonds are formed in the horizons of cryometamorphic soils characterized by high contents of humic substances and organomineral Al-Fe-humus compounds. These are horizons of podzol microprofile (Eg and BHF) in iron-illuvial svetlozem and a humus-impregnated horizon (ELhi,g) in peaty and peat svetlozems. Organomineral Al-Fe-humus compounds, as well as the seasonal freezing of soils, determine the elastic-brittle character of interparticle interactions. The contents of clay fractions, exchangeable bases, and organic and organomineral substances impart viscoelastic properties to these contacts. An enhancement of elastic-brittle properties of soil is observed under the impact of gleying and freezing. The threefold decrease of the structural interaction parameter (∫ Z) when going from automorphic to semihydromorphic conditions indicates a decrease in the resistance of peaty and peat svetlozems to mechanical loads under increasing hydromorphism compared to iron-illuvial svetlozems.

  12. [Oswald Schwarz: a pioneer in psychosomatic urology and sexual medicine].

    PubMed

    Berberich, H J; Schultheiss, D; Kieser, B

    2015-01-01

    Oswald Schwarz, a urologist from Vienna, was a scholar of Anton Ritter von Frisch and Hans Rubritius. As a physician during World War I, he was confronted with numerous bullet wounds to the spinal cord. In 1919, he completed his professorial thesis"Bladder dysfunction as a result of bullet wounds to the spinal cord". Oswald Schwarz was known as a committed surgeon. As an urologist he also treated patients with sexual dysfunction. Besides his practical and scientific urology-related work, he was also interested in psychology and philosophy. He held lectures on both subjects earning himself the nickname, the Urosoph. In the 1920s, Oswald Schwarz belonged to the inner circle of Alfred Adler, the founder of Individual Psychology, and was editor of the first psychosomatic textbook published in German, "Psychological origin and psychotherapy of physical symptoms" (1925). In addition, Schwarz wrote numerous articles and several books on sexual medicine. He also made many valuable contributions to the development of medical anthropology. Altogether, his work includes over 130 publications. Faced with the rise of fascism and National Socialism in Europe, Oswald Schwarz, who was of Jewish origin, emigrated to England in 1934. There he died in 1949. Unfortunately his scientific work has largely been forgotten. The aim of the following article is to remind us of his important contributions to the field.

  13. The Impact of a Ligand Binding on Strand Migration in the SAM-I Riboswitch

    PubMed Central

    Huang, Wei; Kim, Joohyun; Jha, Shantenu; Aboul-ela, Fareed

    2013-01-01

    Riboswitches sense cellular concentrations of small molecules and use this information to adjust synthesis rates of related metabolites. Riboswitches include an aptamer domain to detect the ligand and an expression platform to control gene expression. Previous structural studies of riboswitches largely focused on aptamers, truncating the expression domain to suppress conformational switching. To link ligand/aptamer binding to conformational switching, we constructed models of an S-adenosyl methionine (SAM)-I riboswitch RNA segment incorporating elements of the expression platform, allowing formation of an antiterminator (AT) helix. Using Anton, a computer specially developed for long timescale Molecular Dynamics (MD), we simulated an extended (three microseconds) MD trajectory with SAM bound to a modeled riboswitch RNA segment. Remarkably, we observed a strand migration, converting three base pairs from an antiterminator (AT) helix, characteristic of the transcription ON state, to a P1 helix, characteristic of the OFF state. This conformational switching towards the OFF state is observed only in the presence of SAM. Among seven extended trajectories with three starting structures, the presence of SAM enhances the trend towards the OFF state for two out of three starting structures tested. Our simulation provides a visual demonstration of how a small molecule (<500 MW) binding to a limited surface can trigger a large scale conformational rearrangement in a 40 kDa RNA by perturbing the Free Energy Landscape. Such a mechanism can explain minimal requirements for SAM binding and transcription termination for SAM-I riboswitches previously reported experimentally. PMID:23704854

  14. An historical note on the cell theory.

    PubMed

    Ribatti, Domenico

    2018-03-01

    The development of the microscope was a precondition for the discovery of cells. This instrument magnifies objects too small to be seen by the naked eye. In 1673, the Dutch botanist, Anton van Leeuwenhoek, made a more advanced microscope and reported seeing a myriad of microscopic "animalcules" in water. He also made further studies of red blood cells and sperm cells. Most studies that followed were done on the easily studied plant tissues. Plant cells, rigidly encased in their cell walls, were ideal to study in situ. The cell theory proposes that nucleated cells are the basic structure of plants and animals. This concept was observed and published separately, first by the botanist, Matthias Schleiden, in 1838, and then by the zoologist, Theodor Schwann, in 1839. Their work demonstrated that cells form the basic unit of life of plants and animals. Rudolf Virchow concluded that all living organisms are the sum of single cellular units and that cells multiply. Copyright © 2018 Elsevier Inc. All rights reserved.

  15. Attention changes perceived size of moving visual patterns.

    PubMed

    Anton-Erxleben, Katharina; Henrich, Christian; Treue, Stefan

    2007-08-23

    Spatial attention shifts receptive fields in monkey extrastriate visual cortex toward the focus of attention (S. Ben Hamed, J. R. Duhamel, F. Bremmer, & W. Graf, 2002; C. E. Connor, J. L. Gallant, D. C. Preddie, & D. C. Van Essen, 1996; C. E. Connor, D. C. Preddie, J. L. Gallant, & D. C. Van Essen, 1997; T. Womelsdorf, K. Anton-Erxleben, F. Pieper, & S. Treue, 2006). This distortion in the retinotopic distribution of receptive fields might cause distortions in spatial perception such as an increase of the perceived size of attended stimuli. Here we test for such an effect in human subjects by measuring the point of subjective equality (PSE) for the perceived size of a neutral and an attended stimulus when drawing automatic attention to one of two spatial locations. We found a significant increase in perceived size of attended stimuli. Depending on the absolute stimulus size, this effect ranged from 4% to 12% and was more pronounced for smaller than for larger stimuli. In our experimental design, an attentional effect on task difficulty or a cue bias might influence the PSE measure. We performed control experiments and indeed found such effects, but they could only account for part of the observed results. Our findings demonstrate that the allocation of transient spatial attention onto a visual stimulus increases its perceived size and additionally biases subjects to select this stimulus for a perceptual judgment.

  16. History of the pharmacies in the town of Aleşd, Bihor county

    PubMed Central

    PAŞCA, MANUELA BIANCA; GÎTEA, DANIELA; MOISA, CORINA

    2013-01-01

    In 1848 pharmacist Horváth Mihály established the first pharmacy in Aleşd, called Speranţa (Remény). Following the brief history of this pharmacy we will notice that in 1874 the pharmacy comes into the possession of Kocsiss József. In 1906 the personal rights of the pharmacy are transcribed to Kocsiss Béla, and since 1938 the his son, Kocsiss Dezső, pharmacist, became the new owner. In 1949 the pharmacy was nationalized and became the property of the Pharmaceutical Office Oradea, the pharmacy got the name Farmacia nr. 22 of Aleşd, and continued its activity throughout the whole communist period. Starting with the year 1991 it entered into private system as Angefarm, as the property of Mermeze Gheorghe, pharmacist, and from 2003 until now works under the name Vitalogy 3, as the property of Ghitea Sorin. A second pharmacy, Sfântul Anton was founded in 1937 by pharmacist Herceg Dobreanu Atena, which however had no continuity during the communist period. PMID:26527963

  17. The astrological roots of mesmerism.

    PubMed

    Schaffer, Simon

    2010-06-01

    Franz Anton Mesmer's 1766 thesis on the influence of the planets on the human body, in which he first publicly presented his account of the harmonic forces at work in the microcosm, was substantially copied from the London physician Richard Mead's early eighteenth century tract on solar and lunar effects on the body. The relation between the two texts poses intriguing problems for the historiography of medical astrology: Mesmer's use of Mead has been taken as a sign of the Vienna physician's enlightened modernity while Mead's use of astro-meteorology has been seen as evidence of the survival of antiquated astral medicine in the eighteenth century. Two aspects of this problem are discussed. First, French critics of mesmerism in the 1780s found precedents for animal magnetism in the work of Paracelsus, Fludd and other early modern writers; in so doing, they began to develop a sophisticated history for astrology and astro-meteorology. Second, the close relations between astro-meteorology and Mead's project illustrate how the environmental medical programmes emerged. The making of a history for astrology accompanied the construction of various models of the relation between occult knowledge and its contexts in the enlightenment.

  18. Next Space Station Crew Previews Mission

    2017-10-11

    NASA astronaut Scott Tingle and crewmates Anton Shkaplerov of the Russian space agency Roscosmos and Norishege Kanai of the Japan Aerospace Exploration Agency (JAXA) discussed their upcoming mission to the International Space Station in a news conference on Oct. 11 at NASA’s Johnson Space Center in Houston. Tingle, Shkaplerov and Kanai will launch to the space station aboard the Soyuz MS-07 spacecraft on Dec. 17 from the Baikonur Cosmodrome in Kazakhstan. They will join the station’s Expedition 54 crew, and return to Earth in April 2018 as members of Expedition 55. During a planned four-month mission, the station crew members will take part in about 250 research investigations and technology demonstrations not possible on Earth in order to advance scientific knowledge of Earth, space, physical and biological sciences. Science conducted on the space station continues to yield benefits for humanity and will enable future long-duration human and robotic exploration into deep space, including missions past the Moon and Mars. This will be the first spaceflight for Tingle and Kanai, and the third for Shkaplerov.

  19. ZOONET: perspectives on the evolution of animal form. Meeting report.

    PubMed

    Fischer, Antje H L; Arboleda, Enrique; Egger, Bernhard; Hilbrant, Maarten; McGregor, Alistair P; Cole, Alison G; Daley, Allison C

    2009-11-15

    What drives evolution? This was one of the main questions raised at the final ZOONET meeting in Budapest, Hungary, in November 2008. The meeting marked the conclusion of ZOONET, an EU-funded Marie-Curie Research Training Network comprising nine research groups from all over Europe (Max Telford, University College London; Michael Akam, University of Cambridge; Detlev Arendt, EMBL Heidelberg; Maria Ina Arnone, Stazione Zoologica Anton Dohrn Napoli; Michalis Averof, IMBB Heraklion; Graham Budd, Uppsala University; Richard Copley, University of Oxford; Wim Damen, University of Cologne; Ernst Wimmer, University of Göttingen). ZOONET meetings and practical courses held during the past four years provided researchers from diverse backgrounds--bioinformatics, phylogenetics, embryology, palaeontology, and developmental and molecular biology--the opportunity to discuss their work under a common umbrella of evolutionary developmental biology (Evo Devo). The Budapest meeting emphasized in-depth discussions of the key concepts defining Evo Devo, and bringing together ZOONET researchers with external speakers who were invited to present their views on the evolution of animal form. The discussion sessions addressed four main topics: the driving forces of evolution, segmentation, fossils and phylogeny, and the future of Evo Devo.

  20. [The First School of Vienna and Samuel Hahnemann's pharmaceutical techniques].

    PubMed

    Gantenbein, U L

    2000-01-01

    The First or Elder Vienna School of Medicine was initiated by Gerard van Swieten, the famous pupil of Herman Boerhaave. The aim of this school was to put medicine on new scientific foundations-promoting unprejudiced clinical observation, botanical and chemical research, and the introduction of simple but powerful remedies. One of the products of this school was Anton Störck (1731-1803), appointed Director of Austrian public health and medical education by Empress Maria Theresia. Following the tradition of the Vienna School, Störck was the first scientist to systematically test the effects of so-called poisonous plants (e.g., hemlock, henbane, meadow saffron). Discovering new therapeutic properties in previously dreaded plants, Störck used himself as a subject in experiments to determine tolerable dose levels. As a result of his investigations, Störck was able to successfully treat his patients using the drugs he discovered. Samuel Hahnemann's later writings, including his "Organon", show that he was considerably influenced by Störck's ideas. In fact, Hahnemann's clinical teacher at Vienna was a follower of Störck, Joseph Quarin. Hahnemann's elaborate system of validating homeopath material can be seen as a development and refinement of the techniques he learned in Vienna.

  1. Utilizing the "Plan, Do, Study, Act" Framework to Explore the Process of Curricular Assessment and Redesign in a Physical Therapy Education Program in Suriname.

    PubMed

    Audette, Jennifer Gail; Baldew, Se-Sergio; Chang, Tony C M S; de Vries, Jessica; Ho A Tham, Nancy; Janssen, Johanna; Vyt, Andre

    2017-01-01

    To describe how a multinational team worked together to transition a physical therapy (PT) educational program in Paramaribo, Suriname, from a Bachelor level to a Master of Science in Physical Therapy (MSPT) level. The team was made up of PT faculty from Anton De Kom Universiteit van Suriname (AdeKUS), the Flemish Interuniversity Council University Development Cooperation (VLIR-UOS) leadership, and Health Volunteers Overseas volunteers. In this case study, the process for curricular assessment, redesign, and upgrade is described retrospectively using a Plan, Do, Study, Act (PDSA) framework. PT educational programs in developing countries are eager for upgrade to meet international expectations and to better meet community health-care needs. An ongoing process which included baseline assessment of all aspects of the existing bachelor's program in PT, development of a plan for a MSPT, implementation of the master's program, and evaluation following implementation is described. Curricular assessment and upgrade in resource-limited countries requires the implementation of process-oriented methods. The PDSA process is a useful tool to explore curricular development. The international collaboration described in this paper provides an example of the diligence, consistency, and dedication required to see a project through and achieve success while providing adequate support to the host site. This project might provide valuable insights for those involved in curricular redesign in similar settings.

  2. A Compendium of Volatile Organic Compounds (VOCs) Released By Human Cell Lines

    PubMed Central

    Filipiak, Wojciech; Mochalski, Pawel; Filipiak, Anna; Ager, Clemens; Cumeras, Raquel; Davis, Cristina E.; Agapiou, Agapios; Unterkofler, Karl; Troppmair, Jakob

    2016-01-01

    Volatile organic compounds (VOCs) offer unique insights into ongoing biochemical processes in healthy and diseased humans. Yet, their diagnostic use is hampered by the limited understanding of their biochemical or cellular origin and their frequently unclear link to the underlying diseases. Major advancements are expected from the analyses of human primary cells, cell lines and cultures of microorganisms. In this review, a database of 125 reliably identified VOCs previously reported for human healthy and diseased cells was assembled and their potential origin is discussed. The majority of them have also been observed in studies with other human matrices (breath, urine, saliva, feces, blood, skin emanations). Moreover, continuing improvements of qualitative and quantitative analyses, based on the recommendations of the ISO-11843 guidelines, are suggested for the necessary standardization of analytical procedures and better comparability of results. The data provided contribute to arriving at a more complete human volatilome and suggest potential volatile biomarkers for future validation. Dedication: This review is dedicated to the memory of Prof. Dr. Anton Amann, who sadly passed away on January 6, 2015. He was motivator and motor for the field of breath research. PMID:27160536

  3. Rheological Properties of Nanoparticle Silica-Surfactant Stabilized Crude Oil Emulsions: Influence of Temperature, Nanoparticle Concentration and Water Volume Fraction"

    NASA Astrophysics Data System (ADS)

    Kinsey, Erin; Pales, Ashley; Li, Chunyan; Mu, Linlin; Bai, Lingyun; Clifford, Heather; Darnault, Christophe

    2016-04-01

    Oil in water emulsions occur during oil extraction due to the presence of water, naturally-occurring surface-active agents and mechanical mixing in pipelines or from oil spillage. Emulsions present difficulties for use of oil in fuel and their rheological properties are important to treat environmental impacts of spills. The objective of this study is to assess the rheological characteristics of oil in water emulsions stabilized by 5% NaCl brine, Tween 20 surfactant and silica nanoparticles to gain knowledge about the behavior of oil flow in pipelines and characterize them for environmental applications. Rheological behaviors such as shear rate, shear stress, and viscosity of Prudhoe Bay crude oil emulsions were analyzed with varying percent of water volume fractions (12.5, 25 and 50%), varying weight percent of silica nanoparticles (0.001, 0.01 and 0.1 weight %), with and without 2 CMC Tween 20 nonionic surfactant. Emulsions with varying water volume fractions were analyzed at 20, 40 and 60 degrees Celsius. Flow curve analysis of the emulsions was performed using an Anton-Paar rheometer. Preliminary findings indicate that increased temperature and increasing the concentration of nanoparticles both produced lower shear stress and that the addition of surfactant decreased the viscosity and shear stress of the emulsions.

  4. Doctors in Court, Honour, and Professional Ethics: Two Scandals in Imperial Germany*

    PubMed Central

    Maehle, Andreas-Holger

    2013-01-01

    Summary Comparing two public medical affairs which involved disciplinary proceedings and libel actions, one from Bavaria and one from Prussia, this article analyzes the dynamics behind legal conflicts over doctors’ professional ethics in Imperial Germany. In both the case of Dr Maurice Hutzler, who committed suicide after conflicts with senior colleagues at the Gisela Children’s Hospital and a sentence of the court of honour of the Munich Medical District Society, and the Berlin ‘patient trade’ affair, in which the medical professors Ernst von Leyden, Hermann Senator, Karl Anton Ewald and Carl Posner were accused of having made payments to middlemen for bringing them lucrative private patients, notions of personal and professional honour played a central role. The Munich case highlighted shortcomings of the Bavarian medical court of honour system, which was less developed than its Prussian counterpart. The analysis of the two cases suggests that the ethics of medical practice in early twentieth-century Germany should be viewed as part of a culture of honour. PMID:22303773

  5. An Equation of State for Hypersaline Water in Great Salt Lake, Utah, USA

    Naftz, D.L.; Millero, F.J.; Jones, B.F.; Green, W.R.

    2011-01-01

    Great Salt Lake (GSL) is one of the largest and most saline lakes in the world. In order to accurately model limnological processes in GSL, hydrodynamic calculations require the precise estimation of water density (??) under a variety of environmental conditions. An equation of state was developed with water samples collected from GSL to estimate density as a function of salinity and water temperature. The ?? of water samples from the south arm of GSL was measured as a function of temperature ranging from 278 to 323 degrees Kelvin (oK) and conductivity salinities ranging from 23 to 182 g L-1 using an Anton Paar density meter. These results have been used to develop the following equation of state for GSL (?? = ?? 0.32 kg m-3): ?? - ??0 = 184.01062 + 1.04708 * S - 1.21061*T + 3.14721E - 4*S2 + 0.00199T2 where ??0 is the density of pure water in kg m-3, S is conductivity salinity g L-1, and T is water temperature in degrees Kelvin. ?? 2011 U.S. Government.

  6. How far are rheological parameters from amplitude sweep tests predictable using common physicochemical soil properties?

    NASA Astrophysics Data System (ADS)

    Stoppe, N.; Horn, R.

    2017-01-01

    A basic understanding of soil behavior on the mesoscale resp. macroscale (i.e. soil aggregates resp. bulk soil) requires knowledge of the processes at the microscale (i.e. particle scale), therefore rheological investigations of natural soils receive growing attention. In the present research homogenized and sieved (< 2 mm) samples from Marshland soils of the riparian zone of the River Elbe (North Germany) were analyzed with a modular compact rheometer MCR 300 (Anton Paar, Ostfildern, Germany) with a profiled parallel-plate measuring system. Amplitude sweep tests (AST) with controlled shear deformation were conducted to investigate the viscoelastic properties of the studied soils under oszillatory stress. The gradual depletion of microstructural stiffness during AST cannot only be characterized by the well-known rheological parameters G, G″ and tan δ but also by the dimensionless area parameter integral z, which quantifies the elasticity of microstructure. To discover the physicochemical parameters, which influences the microstructural stiffness, statistical tests were used taking the combined effects of these parameters into account. Although the influence of the individual factors varies depending on soil texture, the physicochemical features significantly affecting soil micro structure were identified. Based on the determined statistical relationships between rheological and physicochemical parameters, pedotransfer functions (PTF) have been developed, which allow a mathematical estimation of the rheological target value integral z. Thus, stabilizing factors are: soil organic matter, concentration of Ca2+, content of CaCO3 and pedogenic iron oxides; whereas the concentration of Na+ and water content represent structurally unfavorable factors.

  7. Detection of biological threats. A challenge for directed molecular evolution.

    PubMed

    Petrenko, Valery A; Sorokulova, Iryna B

    2004-08-01

    The probe technique originated from early attempts of Anton van Leeuwenhoek to contrast microorganisms under the microscope using plant juices, successful staining of tubercle bacilli with synthetic dyes by Paul Ehrlich and discovery of a stain for differentiation of gram-positive and gram-negative bacteria by Hans Christian Gram. The technique relies on the principle that pathogens have unique structural features, which can be recognized by specifically labeled organic molecules. A hundred years of extensive screening efforts led to discovery of a limited assortment of organic probes that are used for identification and differentiation of bacteria. A new challenge--continuous monitoring of biological threats--requires long lasting molecular probes capable of tight specific binding of pathogens in unfavorable conditions. To respond to the challenge, probe technology is being revolutionized by utilizing methods of combinatorial chemistry, phage display and directed molecular evolution. This review describes how molecular evolution methods are applied for development of peptide, antibody and phage probes, and summarizes the author's own data on development of landscape phage probes against Salmonella typhimurium. The performance of the probes in detection of Salmonella is illustrated by a precipitation test, enzyme-linked immunosorbent assay (ELISA), fluorescence-activated cell sorting (FACS) and fluorescent, optical and electron microscopy.

  8. Observations of CI Cam needed to support spectroscopy

    NASA Astrophysics Data System (ADS)

    Waagen, Elizabeth O.

    2016-10-01

    Kelly Gourdji and Marcella Wijngaarden (graduate students at the University of Amsterdam/Anton Pannekoek Institute for Astronomy) have requested AAVSO observers' assistance in providing optical photometry of CI Cam in support of their high-resolution spectroscopy from now through January 2017. They write: "...We are currently observing the variable star CI Cam (the B[e] optical counterpart of a HMXB system) with the HERMES spectrograph at the Mercator Telescope in La Palma. Having observed the star for three nights now, the object appears to be in outburst. In particular, H alpha was measured to be 80 times the continuum flux, and increasing between Oct. 9 and 12. This is similar to the previous outburst in 2004/5. Photometric data obtained during the 2004/5 outburst suggested an outburst duration of about 3 months and a peak brightness of 11.2 in the V band." More information is available in ATel #9634 (Wijngaarden et al.). Multiple snapshot observations per night in BVRI are requested beginning immediately and continuing through January 2017. Time series are not necessary unless requested later via an AAVSO Special Notice. Observations made using other filters will be useful as well as long as there are multiple observations in these bands. Finder charts with sequence may be created using the AAVSO Variable Star Plotter (https://www.aavso.org/vsp). Observations should be submitted to the AAVSO International Database. See full Alert Notice for more details.

  9. Rheological Characterization and Cluster Classification of Iranian Commercial Foods, Drinks and Desserts to Recommend for Esophageal Dysphagia Diets

    PubMed Central

    ZARGARAAN, Azizollaah; OMARAEE, Yasaman; RASTMANESH, Reza; TAHERI, Negin; FADAVI, Ghasem; FADAEI, Morteza; MOHAMMADIFAR, Mohammad Amin

    2013-01-01

    Abstract Background In the absence of dysphagia-oriented food products, rheological characterization of available food items is of importance for safe swallowing and adequate nutrient intake of dysphagic patients. In this way, introducing alternative items (with similar ease of swallow) is helpful to improve quality of life and nutritional intake of esophageal cancer dysphagia patients. The present study aimed at rheological characterization and cluster classification of potentially suitable foodstuffs marketed in Iran for their possible use in dysphagia diets. Methods In this descriptive study, rheological data were obtained during January and February 2012 in Rheology Lab of National Nutrition and Food Technology Research Institute Tehran, Iran. Steady state and oscillatory shear parameters of 39 commercial samples were obtained using a Physica MCR 301 rheometer (Anton-Paar, GmbH, Graz, Austria). Matlab Fuzzy Logic Toolbox (R2012 a) was utilized for cluster classification of the samples. Results Using an extended list of rheological parameters and fuzzy logic methods, 39 commercial samples (drinks, main courses and desserts) were divided to 5 clusters and degree of membership to each cluster was stated by a number between 0 and 0.99. Conclusion Considering apparent viscosity of foodstuffs as a single criterion for classification of dysphagia-oriented food products is shortcoming of current guidelines in dysphagia diets. Authors proposed to some revisions in classification of dysphagia-oriented food products and including more rheological parameters (especially, viscoelastic parameters) in the classification. PMID:26060647

  10. Rheological Characterization and Cluster Classification of Iranian Commercial Foods, Drinks and Desserts to Recommend for Esophageal Dysphagia Diets.

    PubMed

    Zargaraan, Azizollaah; Omaraee, Yasaman; Rastmanesh, Reza; Taheri, Negin; Fadavi, Ghasem; Fadaei, Morteza; Mohammadifar, Mohammad Amin

    2013-12-01

    In the absence of dysphagia-oriented food products, rheological characterization of available food items is of importance for safe swallowing and adequate nutrient intake of dysphagic patients. In this way, introducing alternative items (with similar ease of swallow) is helpful to improve quality of life and nutritional intake of esophageal cancer dysphagia patients. The present study aimed at rheological characterization and cluster classification of potentially suitable foodstuffs marketed in Iran for their possible use in dysphagia diets. In this descriptive study, rheological data were obtained during January and February 2012 in Rheology Lab of National Nutrition and Food Technology Research Institute Tehran, Iran. Steady state and oscillatory shear parameters of 39 commercial samples were obtained using a Physica MCR 301 rheometer (Anton-Paar, GmbH, Graz, Austria). Matlab Fuzzy Logic Toolbox (R2012 a) was utilized for cluster classification of the samples. Using an extended list of rheological parameters and fuzzy logic methods, 39 commercial samples (drinks, main courses and desserts) were divided to 5 clusters and degree of membership to each cluster was stated by a number between 0 and 0.99. Considering apparent viscosity of foodstuffs as a single criterion for classification of dysphagia-oriented food products is shortcoming of current guidelines in dysphagia diets. Authors proposed to some revisions in classification of dysphagia-oriented food products and including more rheological parameters (especially, viscoelastic parameters) in the classification.

  11. Sperm Parameters: Paradigmatic Index of Good Health and Longevity

    PubMed Central

    Omu, Alexander E.

    2013-01-01

    Since the discovery of spermatozoon by Anton van Leeuwenhoek in 1677, there has been an ever increasing understanding of its role in reproduction. Many factors adversely affect sperm quality, including varicocele, accessory gland infection, immunological factors, congenital abnormalities, and iatrogenic systemic and endocrine causes, such as diabetes mellitus, obesity, metabolic syndrome, and smoking. The mechanisms responsible for the association between poor sperm parameters and ill health may include oxidative stress, low-grade inflammation, low testosterone, and low sex-hormone-binding globulin. Oxidative stress in the testicular microenvironment may result in decreased spermatogenesis and sperm DNA damage, loss of sperm motility, and abnormal sperm morphology. Low testosterone caused by advanced age, visceral obesity, and inflammation is associated with the development of cardiovascular disease. Hence, semen analysis has an important role in the routine evaluation of idiopathic male infertility, usually manifested as low sperm counts, impaired sperm motility, or absence of sperm, and remains the most common single diagnostic tool. Several studies have shown an inverse relationship between semen quality and medical disorders. This review elucidates the effect of medical disorders and social habits on sperm quality, the mechanisms that are involved in the impairment of sperm quality, and whether or not sperm quality can be used as an index of good health and longevity in a man. PMID:24051979

  12. European Glaucoma Society Terminology and Guidelines for Glaucoma, 4th Edition - Part 1Supported by the EGS Foundation

    PubMed Central

    2017-01-01

    Nordmann Norbert Pfeiffer Luis Abegao Pinto Luca Rossetti John Salmon Leo Schmetterer Riccardo Scotto Tarek Shaarawy Ingeborg Stalmans Gordana Sunaric Megevand Ernst Tamm John Thygesen Fotis Topouzis Carlo Enrico Traverso Anja Tuulonen Ananth Viswanathan Thierry Zeyen The Guidelines Task Force  Luca Bagnasco Anders Heijl Carlo Enrico Traverso Augusto Azuara Blanco Alessandro Bagnis David Garway Heath Michele Iester Yves Lachkar Ingeborg Stalmans Gordana Sunaric Mégevand Fotis Topouzis Anja Tuulonen Ananth Viswanathan The EGS Executive Committee  Carlo Enrico Traverso (President) Anja Tuulonen (Vice President) Roger Hitchings (Past President) Anton Hommer (Treasurer) Barbara Cvenkel Julian Garcia Feijoo David Garway Heath Norbert Pfeiffer Ingeborg Stalmans The Board of the European Glaucoma Society Foundation  Roger Hitchings (Chair) Carlo E. Traverso (Vice Chair) Franz Grehn Anders Heijl John Thygesen Fotis Topouzis Thierry Zeyen The EGS Committees  CME and Certification  Gordana Sunaric Mégevand (Chair) Carlo Enrico Traverso (Co-chair) Delivery of Care  Anton Hommer (Chair) EU Action  Thierry Zeyen (Chair) Carlo E. Traverso (Co-chair) Education  John Thygesen (Chair) Fotis Topouzis (Co-chair) Glaucogene  Ananth Viswanathan (Chair) Fotis Topouzis (Co-chair) Industry Liaison  Roger Hitchings (Chair) Information Technology  Ingeborg Stalmans (Chair) Carlo E. Traverso (Co-chair) National Society Liaison  Anders Heijl (Chair) Program Planning  Fotis Topouzis (Chair) Ingeborg Stalmans (Co-chair) Quality and Outcomes  Anja Tuulonen (Chair) Augusto Azuara Blanco (Co-chair) Scientific  Franz Grehn (Chair) David Garway Heath (Co-chair) PMID:27378485

  13. Peer review statement

    NASA Astrophysics Data System (ADS)

    2010-08-01

    All papers published in this Volume 12 of IOP Conference Series: Earth and Environmental Science have been peer reviewed through processes administered by the editors of the 25th IAHR Symposium on Hydraulic Machinery and Systems proceedings, Professor Romeo Susan-Resiga, Dr Sebastian Muntean and Dr Sandor Bernad. Reviews were conducted by expert referees from the Scientific Committee to the professional and scientific standards expected of a proceedings journal published by IOP Publishing. The members of the Scientific Committee who selected and reviewed the papers included in the Proceedings of the 25th IAHR Symposium on Hydraulic Machinery and Systems are: Anton ANTONTechnical University of Civil Engineering, BucharestRomania François AVELLANEcole Polytechnique Fédérale de LausanneSwitzerland Fidel ARZOLAEDELCAVenezuela Thomas ASCHENBRENNERVoith Hydro Gmb H & Co. KG, HeidenheimGermany Anton BERGANTLitostroj Power d.o.o., LjubljanaSlovenia Gerard BOISENSAM, LilleFrance Hermod BREKKENTNU, TrondheimNorway Stuart COULSON Voith Hydro Inc., YorkUSA Eduard EGUSQUIZAPolytechnical University Catalonia BarcelonaSpain Arpad FAYUniversity of MiskolczHungary Richard FISHERVoith Hydro Inc., York USA Regiane FORTES-PATELLAInstitut Polytechnique de GrenobleFrance Aleksandar GAJICUniversity of BelgradeSerbia Arno GEHRERAndritz Hydro GrazAustria José GONZÁLEZUniversidad de OviedoSpain François GUIBAULTEcole Polytechnique de MontrealCanada Chisachi KATOUniversity of TokyoJapan Kwang-Yong KIMInha University, IncheonKorea Jiri KOUTNIKVoith Hydro Gmb H & Co. KG, HeidenheimGermany Adrian LUNGUDunarea de Jos University of GalatiRomania Christophe NICOLETPower Vision Engineering Sàrl, LausanneSwitzerland Torbjøm K. NIELSENNTNU, TrodheimNorway Michihiro NISHIKyushu Institute of TechnologyJapan Maryse PAGEHydro Quebec IREQ, VarennesCanada Etienne PARKINSONAndritz Hydro LtdSwitzerland František POCHYLYBrno UniversityCzech Republic Stefan RIEDELBAUCHVoith Hydro Gmb H & Co. KG

  14. Microsecond Molecular Dynamics Simulations of Lipid Mixing

    PubMed Central

    2015-01-01

    Molecular dynamics (MD) simulations of membranes are often hindered by the slow lateral diffusion of lipids and the limited time scale of MD. In order to study the dynamics of mixing and characterize the lateral distribution of lipids in converged mixtures, we report microsecond-long all-atom MD simulations performed on the special-purpose machine Anton. Two types of mixed bilayers, POPE:POPG (3:1) and POPC:cholesterol (2:1), as well as a pure POPC bilayer, were each simulated for up to 2 μs. These simulations show that POPE:POPG and POPC:cholesterol are each fully miscible at the simulated conditions, with the final states of the mixed bilayers similar to a random mixture. By simulating three POPE:POPG bilayers at different NaCl concentrations (0, 0.15, and 1 M), we also examined the effect of salt concentration on lipid mixing. While an increase in NaCl concentration is shown to affect the area per lipid, tail order, and lipid lateral diffusion, the final states of mixing remain unaltered, which is explained by the largely uniform increase in Na+ ions around POPE and POPG. Direct measurement of water permeation reveals that the POPE:POPG bilayer with 1 M NaCl has reduced water permeability compared with those at zero or low salt concentration. Our calculations provide a benchmark to estimate the convergence time scale of all-atom MD simulations of lipid mixing. Additionally, equilibrated structures of POPE:POPG and POPC:cholesterol, which are frequently used to mimic bacterial and mammalian membranes, respectively, can be used as starting points of simulations involving these membranes. PMID:25237736

  15. Evaluation of tribological properties of selected engine oils during operation of the friction pairs of steel-on-steel

    NASA Astrophysics Data System (ADS)

    Barszcz, Marcin; Józwik, Jerzy; Dziedzic, Krzysztof; Stec, Kamil

    2017-10-01

    The paper includes an assessment of the tribological properties of mineral and synthetic Lotos oil marked SAE 15W/40 and SAE 5W/40 at ambient temperature and 100 °C. The evaluation was based on the analysis of the tribological properties of friction couple consumables. Tribological tests were performed using the Anton Paar THT 1000 high temperature tribotester according to ASTM G133. Tribological properties were investigated using the "ball on disc" method. The change of friction coefficient, friction couple temperature, volume wear of samples and counter-samples and Hertz stresses were evaluated. In addition, hardness tests of the friction couple materials as well as surface roughness before and after friction were performed. On the basis of tribological studies, it was noted that Lotos Synthetic 5W/40 oil has better cooling properties compared. For both oils the coefficient of friction was lower at ambient temperature than at 100 °C. The highest value of volume wear of the sample was noted for the combination lubricated with Mineral Oil 15W/40 at 100 °C (0.0143 mm3) while for counter-sample lubricated with synthetic oil at ambient temperature (0.0039 mm3). The highest sample wear coefficient was recorded for the mineral oil lubricated at temperature of 100 °C (3.585*10-7 mm3/N/m) while for counter-sample lubricated with synthetic oil at ambient temperature (9.8768*10-8 mm3/N/m). The Hertz stress for each test couple had a value of 1.787 GPa.

  16. PREFACE: Eurotherm Seminar 102: Thermal Management of Electronic Systems

    NASA Astrophysics Data System (ADS)

    Punch, J.; Walsh, E.

    2014-07-01

    About EUROTHERM The aim of the EUROTHERM Committee (www.eurothermcommittee.eu) is to promote and foster European cooperation in Thermal Sciences and Heat Transfer by gathering together scientists and engineers working in specialized areas. The Committee consists of members representing and appointed by national bodies in the EU countries. The current President of EUROTHERM is Professor Anton van Steenhoven from the University of Eindhoven (The Netherlands). The Committee organizes and coordinates European scientific events such as the EUROTHERM Seminars (about 4 per year) and the European Thermal Sciences Conference (every 4 years). About EUROTHERM Seminar 102 (www.eurothermseminar102.com) This seminar, part of the long-running series of European seminars on the thermal sciences, took place in June 2014 at the University of Limerick in Limerick, Ireland. The seminar addressed the topic of 'Thermal Management of Electronic Systems', a critical contemporary application area which represents a vibrant challenge for practitioners of the thermal sciences. We convey special thanks to the reviewers who have evaluated these papers. We also thank the scientific committee, consisting of internationally recognized experts. Their role has been to manage the evaluation of abstracts and the papers selection process as co-coordinators for specific topics. This seminar was hosted by the Stokes Institute at the University of Limerick. It could not have been organized without the efficient help of our administrators and technicians for IT support. This volume of Journal of Physics: Conference Series includes 27 articles presented at the seminar. Dr. Jeff Punch, Chair Stokes Institute, University of Limerick, Limerick, Ireland Email: jeff.punch@ul.ie Prof. Edmond Walsh, Co-Chair Associate Professor, Osney Laboratories, Department of Engineering Science, University of Oxford, UK Email: edmond.walsh@bnc.ox.ac.uk

  17. PREFACE: 6th European Thermal Sciences Conference (Eurotherm 2012)

    NASA Astrophysics Data System (ADS)

    Petit, Daniel; Le Niliot, Christophe

    2012-11-01

    About EUROTHERM The aim of the EUROTHERM Committee (www.eurothermcommittee.eu) is to promote and foster European cooperation in Thermal Sciences and Heat Transfer by gathering together scientists and engineers working in specialized areas. The Committee consists of members representing and appointed by national bodies in the EU countries. The current President of EUROTHERM is Professor Anton van Steenhoven from the University of Eindhoven (The Netherlands). The Committee organizes and coordinates European scientific events such as the EUROTHERM Seminars (about 4 per year) and the European Thermal Sciences Conference (every 4 years). About the conference This sixth in the series of European Thermal Sciences Conferences (www.eurotherm2012.com) took place in France, in the Conference Centre of Poitiers, Futuroscope. We address special thanks to the 225 reviewers, coming from different European countries, who have evaluated these papers. We also thank the scientific committee, consisting of some EUROTHERM Committee members together with other internationally recognized experts. Their role has been to manage the evaluation of abstracts and the papers selection process as co-coordinators for specific topics. This conference is the joint effort of two laboratories: the PPRIME Institute in Poitiers and the IUSTI laboratory in Marseille. It could not be organized without the efficient help of our secretaries and our technician for the IT support. This volume of Journal of Physics: Conference Series includes 180 articles presented at the conference. Professor Daniel PETIT Chairman, PPRIME Poitiers, France Institut P'(UPR CNRS 3346) ENSMA 1 av. Clément Ader - BP40109 86961 Futuroscope-Chasseneuil France daniel.petit@ensma.fr Professor Christophe LE NILIOT Co-chairman, IUSTI Marseille, France Laboratoire IUSTI UMR CNRS 6595 Technopôle de Chateau-Gombert 5, rue Enrico Fermi 13 453 MARSEILLE CEDEX 13 France christophe.leniliot@polytech.univ-mrs.fr

  18. Feasibility study of entrance and exit dose measurements at the contra lateral breast with alanine/electron spin resonance dosimetry in volumetric modulated radiotherapy of breast cancer

    NASA Astrophysics Data System (ADS)

    Wagner, Daniela M.; Hüttenrauch, Petra; Anton, Mathias; von Voigts-Rhetz, Philip; Zink, Klemens; Wolff, Hendrik A.

    2017-07-01

    The Physikalisch-Technische Bundesanstalt has established a secondary standard measurement system for the dose to water, D W, based on alanine/ESR (Anton et al 2013 Phys. Med. Biol. 58 3259-82). The aim of this study was to test the established measurement system for the out-of-field measurements of inpatients with breast cancer. A set of five alanine pellets were affixed to the skin of each patient at the contra lateral breast beginning at the sternum and extending over the mammilla to the distal surface. During 28 fractions with 2.2 Gy per fraction, the accumulated dose was measured in four patients. A cone beam computer tomography (CBCT) scan was generated for setup purposes before every treatment. The reference CT dataset was registered rigidly and deformably to the CBCT dataset for 28 fractions. To take the actual alanine pellet position into account, the dose distribution was calculated for every fraction using the Acuros XB algorithm. The results of the ESR measurements were compared to the calculated doses. The maximum dose measured at the sternum was 19.9 Gy  ±  0.4 Gy, decreasing to 6.8 Gy  ±  0.2 Gy at the mammilla and 4.5 Gy  ±  0.1 Gy at the distal surface of the contra lateral breast. The absolute differences between the calculated and measured doses ranged from  -1.9 Gy to 0.9 Gy. No systematic error could be seen. It was possible to achieve a combined standard uncertainty of 1.63% for D W  =  5 Gy for the measured dose. The alanine/ESR method is feasible for in vivo measurements.

  19. Premotor activations in response to visually presented single letters depend on the hand used to write: a study on left-handers.

    PubMed

    Longcamp, Marieke; Anton, Jean-Luc; Roth, Muriel; Velay, Jean-Luc

    2005-01-01

    In a previous fMRI study on right-handers (Rhrs), we reported that part of the left ventral premotor cortex (BA6) was activated when alphabetical characters were passively observed and that the same region was also involved in handwriting [Longcamp, M., Anton, J. L., Roth, M., & Velay, J. L. (2003). Visual presentation of single letters activates a premotor area involved in writing. NeuroImage, 19, 1492-1500]. We therefore suggested that letter-viewing may induce automatic involvement of handwriting movements. In the present study, in order to confirm this hypothesis, we carried out a similar fMRI experiment on a group of left-handed subjects (Lhrs). We reasoned that if the above assumption was correct, visual perception of letters by Lhrs might automatically activate cortical motor areas coding for left-handed writing movements, i.e., areas located in the right hemisphere. The visual stimuli used here were either single letters, single pseudoletters, or a control stimulus. The subjects were asked to watch these stimuli attentively, and no response was required. The results showed that a ventral premotor cortical area (BA6) in the right hemisphere was specifically activated when Lhrs looked at letters and not at pseudoletters. This right area was symmetrically located with respect to the left one activated under the same circumstances in Rhrs. This finding supports the hypothesis that visual perception of written language evokes covert motor processes. In addition, a bilateral area, also located in the premotor cortex (BA6), but more ventrally and medially, was found to be activated in response to both letters and pseudoletters. This premotor region, which was not activated correspondingly in Rhrs, might be involved in the processing of graphic stimuli, whatever their degree of familiarity.

  20. DynAMo: A Modular Platform for Monitoring Process, Outcome, and Algorithm-Based Treatment Planning in Psychotherapy.

    PubMed

    Kaiser, Tim; Laireiter, Anton Rupert

    2017-07-20

    , Anton Rupert Laireiter. Originally published in JMIR Medical Informatics (http://medinform.jmir.org), 20.07.2017.

  1. Rheological Characterization of Vegetal Pear (Sechium edule)

    NASA Astrophysics Data System (ADS)

    Castillo-Reyes, José A.; Luna-Solano, Guadalupe; Cantú-Lozano, Denis

    2008-07-01

    The national production of Mexican vegetal pear (Sechium edule) is located at the present time in more than 130,000 ton/year. The vegetal pear that produced in the center zone of the state of Veracruz is known in international markets; however it is a product that practically has not been studied. This work identifies the rheological behavior of vegetal pear (Sechium edule). A rheometer MCR301 of Anton Paar was utilized for viscosity and shear stress measurements. The objective of this experimental was modeling the rheological behavior of vegetal pear suspensions at three concentrations (1, 2 and 3% w/w), three particle size (1.00, 1.19 and 1.40 mm), at the same conditions of temperature (25, 40 and 70 °C). The results showed that all the suspensions there was a phenomenological behavior as a dilatants fluid (n>1) the performance of flow was represented by the Herschel-Bulkley model, and present values of "yield stress" between from 0.1 to 15 Pa for the different experiments. During evaluation of the activation energy of the suspensions of vegetal pear was found that decreases from 154.4039 kJ/mol to 9.1086 kJ/mol for a particle size of 1.00 mm to 1.4 mm, which implies that the effect of temperature is higher with smaller grains, in this case 1.00 mm. Furthermore, we assessed the effect of particle size by the Péclet number, showing an increase of the viscosity when the Péclet number also increases.

  2. Changes in visual and sensory-motor resting-state functional connectivity support motor learning by observing.

    PubMed

    McGregor, Heather R; Gribble, Paul L

    2015-07-01

    Motor learning occurs not only through direct first-hand experience but also through observation (Mattar AA, Gribble PL. Neuron 46: 153-160, 2005). When observing the actions of others, we activate many of the same brain regions involved in performing those actions ourselves (Malfait N, Valyear KF, Culham JC, Anton JL, Brown LE, Gribble PL. J Cogn Neurosci 22: 1493-1503, 2010). Links between neural systems for vision and action have been reported in neurophysiological (Strafella AP, Paus T. Neuroreport 11: 2289-2292, 2000; Watkins KE, Strafella AP, Paus T. Neuropsychologia 41: 989-994, 2003), brain imaging (Buccino G, Binkofski F, Fink GR, Fadiga L, Fogassi L, Gallese V, Seitz RJ, Zilles K, Rizzolatti G, Freund HJ. Eur J Neurosci 13: 400-404, 2001; Iacoboni M, Woods RP, Brass M, Bekkering H, Mazziotta JC, Rizzolatti G. Science 286: 2526-2528, 1999), and eye tracking (Flanagan JR, Johansson RS. Nature 424: 769-771, 2003) studies. Here we used a force field learning paradigm coupled with resting-state fMRI to investigate the brain areas involved in motor learning by observing. We examined changes in resting-state functional connectivity (FC) after an observational learning task and found a network consisting of V5/MT, cerebellum, and primary motor and somatosensory cortices in which changes in FC were correlated with the amount of motor learning achieved through observation, as assessed behaviorally after resting-state fMRI scans. The observed FC changes in this network are not due to visual attention to motion or observation of movement errors but rather are specifically linked to motor learning. These results support the idea that brain networks linking action observation and motor control also facilitate motor learning. Copyright © 2015 the American Physiological Society.

  3. Participation of D.O. Muhleman as a Co-Investigator on the Mars Observer Laser Altimeter (MOLA) Team

    NASA Technical Reports Server (NTRS)

    Muhleman, Duane O.

    2004-01-01

    The Co-I has been a principle member of the MOLA Team since the beginning of the Mars Observer Project and the MOLA Team formation. The basic area of research for the Co-I involved the interactions of the MOLA laser beam with the Mars atmosphere, ice fields and surface in general. The Co-I was assisted by one graduate student, and later a research assistant, Anton Ivanov, throughout the reporting period. Dr. Ivanov received a PhD from Caltech in 2000 from research involving the MOLA project. Dr. Ivanov continued with the MOLA project after receiving his degree as a research assistant to Professor Muhleman. Most of the funding from this grant was used to support Dr. Ivanov during the later years. The primary results of these investigations included the measurement of Mars atmospheric opacity at the 1 micron wavelength of the laser, the effects of dust within the craters and canyons of Mars, and a detailed study of the North Polar Ice Cap in terms of ice sublimation and the current structure of that ice cap. We were able to show that the sublimation of the ice on the polar cap would create the current average shape of the norther cap. Extensive data collection and study were made of the Mars surface 1 micron reflectivity until the laser mechanically failed during the reporting period. Reflectivity maps of Mars were produced although there were serious problems of the laser echo signal strength calibration. After that event the efforts were mainly to complete the older investigations. All of the work supported by this grant was theoretical in nature and did not lead to any patents.

  4. Determination of osmium concentrations and (187)Os/(188)Os of crude oils and source rocks by coupling high-pressure, high-temperature digestion with sparging OsO(4) into a multicollector inductively coupled plasma mass spectrometer.

    PubMed

    Sen, Indra S; Peucker-Ehrenbrink, Bernhard

    2014-03-18

    The (187)Os/(188)Os ratio that is based on the β(-)-decay of (187)Re to (187)Os (t1/2 = 41.6 billion years) is widely used to investigate petroleum system processes. Despite its broad applicability to studies of hydrocarbon deposits worldwide, a suitable matrix-matched reference material for Os analysis does not exist. In this study, a method that enables Os isotope measurement of crude oil with in-line Os separation and purification from the sample matrix is proposed. The method to analyze Os concentration and (187)Os/(187)Os involves sample digestion under high pressure and high temperature using a high pressure asher (HPA-S, Anton Paar), sparging of volatile osmium tetroxide from the sample solution, and measurements using multicollector inductively coupled plasma mass spectrometry (MC-ICPMS). This methods significantly reduced the total procedural time compared to conventional Carius tube digestion followed by Os separation and purification using solvent extraction, microdistillation and N-TIMS analysis. The method yields Os concentration (28 ± 4 pg g(-1)) and (187)Os/(188)Os (1.62 ± 0.15) of commercially available crude oil reference material NIST 8505 (1 S.D., n = 6). The reference material NIST 8505 is homogeneous with respect to Os concentration at a test portion size of 0.2 g. Therefore, (187)Os/(188)Os composition and Os concentration of NIST 8505 can serve as a matrix-matched reference material for Os analysis. Data quality was assessed by repeated measurements of the USGS shale reference material SCo-1 (sample matrix similar to petroleum source rock) and the widely used Liquid Os Standard solution (LOsSt). The within-laboratory reproducibility of (187)Os/(188)Os for a 5 pg of LOsSt solution, analyzed with this method over a period of 12 months was ∼1.4% (1 S.D., n = 26), respectively.

  5. Applications and Implications of Fractional Dynamics for Dielectric Relaxation

    NASA Astrophysics Data System (ADS)

    Hilfer, R.

    This article summarizes briefly the presentation given by the author at the NATO Advanced Research Workshop on "Broadband Dielectric Spectroscopy and its Advanced Technological Applications", held in Perpignan, France, in September 2011. The purpose of the invited presentation at the workshop was to review and summarize the basic theory of fractional dynamics (Hilfer, Phys Rev E 48:2466, 1993; Hilfer and Anton, Phys Rev E Rapid Commun 51:R848, 1995; Hilfer, Fractals 3(1):211, 1995; Hilfer, Chaos Solitons Fractals 5:1475, 1995; Hilfer, Fractals 3:549, 1995; Hilfer, Physica A 221:89, 1995; Hilfer, On fractional diffusion and its relation with continuous time random walks. In: Pekalski et al. (eds) Anomalous diffusion: from basis to applications. Springer, Berlin, p 77, 1999; Hilfer, Fractional evolution equations and irreversibility. In: Helbing et al. (eds) Traffic and granular flow'99. Springer, Berlin, p 215, 2000; Hilfer, Fractional time evolution. In: Hilfer (ed) Applications of fractional calculus in physics. World Scientific, Singapore, p 87, 2000; Hilfer, Remarks on fractional time. In: Castell and Ischebeck (eds) Time, quantum and information. Springer, Berlin, p 235, 2003; Hilfer, Physica A 329:35, 2003; Hilfer, Threefold introduction to fractional derivatives. In: Klages et al. (eds) Anomalous transport: foundations and applications. Wiley-VCH, Weinheim, pp 17-74, 2008; Hilfer, Foundations of fractional dynamics: a short account. In: Klafter et al. (eds) Fractional dynamics: recent advances. World Scientific, Singapore, p 207, 2011) and demonstrate its relevance and application to broadband dielectric spectroscopy (Hilfer, J Phys Condens Matter 14:2297, 2002; Hilfer, Chem Phys 284:399, 2002; Hilfer, Fractals 11:251, 2003; Hilfer et al., Fractional Calc Appl Anal 12:299, 2009). It was argued, that broadband dielectric spectroscopy might be useful to test effective field theories based on fractional dynamics.

  6. The Works of Henry Moseley, 1887-1915

    NASA Astrophysics Data System (ADS)

    Scerri, Eric

    2013-04-01

    In 1913 Henry Moseley, an unknown young English physicist published an article in the Philosophical Magazine under the title of ``The High Frequency Spectra of the Elements.'' The 10-page article was to have far reaching implications in both chemistry and physics and helped to resolve a major conundrum in the periodic table of the elements. The talk will briefly examine the life and work of Moseley who died tragically while fighting in the trenches of World War I in 1915. The build-up to the discovery of atomic number took several different avenues including contributions from Rutherford and Barkla. However the more direct motivation for Moseley's work, as he readily acknowledged, were the articles of an unknown Dutch econometrician Anton Van den Broek who attempted to improve on Mendeleev's periodic table. Moseley began as a student of Rutherford at Manchester and took a keen interest in the development of research using X-rays following the work of Roentgen, von Laue and Bragg. Although Rutherford was at first reluctant to enter this new field he soon yielded to young Moseley's request and sent him to Leeds for brief training with Bragg. On returning to Manchester, Moseley devised an ingenious apparatus in which a set of metal samples could be rotated so as to become the target for a beam of electrons in order to measure the frequencies of the emitted K X-rays. The first set of such experiments used nine successive elements in the periodic table, from titanium to zinc. Moseley's now immense fame rests with the results of this study as well as a subsequent one which extended the study into a further 30 elements, in addition to the use that his method was put to by himself as well as subsequent chemists and physicists.

  7. Critical properties and high-pressure volumetric behavior of the carbon dioxide+propane system at T=308.15 k. Krichevskii function and related thermodynamic properties.

    PubMed

    Blanco, Sofía T; Gil, Laura; García-Giménez, Pilar; Artal, Manuela; Otín, Santos; Velasco, Inmaculada

    2009-05-21

    Critical properties and volumetric behavior for the {CO2(1)+C3H8(2)} system have been studied. The critical locus was measured with a flow apparatus and detected by critical opalescence. For the mixtures, repeatabilities in critical temperature and pressure are rTcAnton Paar DMA 512-P vibrating-tube densimeter calibrated with the forced path mechanical calibration model. The mean relative standard deviation of density, srhor, was estimated to be better than 0.1%, and the uncertainties in temperature and pressure are +/-0.01 K and +/-0.001 MPa, respectively. In the experimental setup, an uncertainty in the mole fraction, u(xj)=+/-0.0015, has been achieved. Other properties related to P-rho-T-x data such as saturated densities, rhoL and rhoV, compressibility factor, Z, excess molar volumes,VmE, and partial molar volumes, Vi, have been calculated. Structural properties such as direct and total correlation function integrals and cluster size were calculated using the Krichevskii function concept. Both the critical and volumetric behavior have been compared with literature data and with those obtained from the PC-SAFT and Patel-Teja equations of state.

  8. Analysis of the IMS Location Accuracy in Northern Eurasia and North America Using Regional and Global Pn Travel-time Tables

    NASA Astrophysics Data System (ADS)

    United States Calibration Working Group, Russian Federation/

    - Joint Research Program of Seismic Calibration of the International Monitoring System (IMS) in Northern Eurasia and North America has been signed by the Nuclear Treaty Programs Office (NTPO), Department of Defense USA, and the Special Monitoring Service (SMS) of the Ministry of Defense, Russian Federation (RF). Under the Program historical data from nuclear and large chemical explosions of known location and shot time, together with appropriate geological and geophysical data, has been used to derive regional Pn/P travel-time tables for seismic event location within the lower 48 States of the USA and the European part of the RF. These travel-time tables are up to 5seconds faster in shields than the IASPEI91 tables, and up to 5seconds slower in the Western USA. Relocation experiments using the regional Pn travel-time curves and surrogate networks for the IMS network generally improved locations for regional seismic events. The distance between true and estimated location (mislocation) was decreased from an average of 18.8km for the IASPEI91 tables to 10.1km for the regional Pn travel-time tables. However, the regional travel-time table approach has limitations caused by travel-time variations inside major tectonic provinces and paths crossing several tectonic provinces with substantially different crustal and upper mantle velocity structure.The RF members of the Calibration Working Group (WG): Colonel Vyacheslav Gordon (chairman); Dr. Prof. Marat Mamsurov, and Dr. Nikolai Vasiliev. The US members of the WG: Dr. Anton Dainty (chairman), Dr. Douglas Baumgardt, Mr. John Murphy, Dr. Robert North, and Dr. Vladislav Ryaboy.

  9. Modeling and Assessing Insect Disturbance on Boreal Forests in the Krasnoyarsk region of Russia by Employing the FAREAST Gap Model and Local Forest Inventory and Disturbance Data.

    NASA Astrophysics Data System (ADS)

    Erler, A. E.; Shuman, J. K.; Soukhavolosky, V.; Kovalev, A.; Stevens, T.; Shugart, H. H.

    2008-12-01

    FAREAST: an individual-based forest dynamics model was initially developed to simulate the forested region around Changbai Mountain in northern China. In recent years the model has been expanded across Siberia. The model output for biomass (tCha-1) has been verified against forest inventory data for a number of sites across Russia. With this success, an additional module for the model was written by Anton Kovalev to predict the impact of insect disturbance on the Boreal forests. This model predicts the probability of an insect outbreak occurring, and then, by assessing each individual tree in a modeled stand, predicts whether a tree will be killed as a result of insect predation. From this, a disturbance index is calculated that includes lost biomass as a result of insect disturbance and subsequent species composition. This disturbance "fingerprint" is being compared to forest inventory and insect disturbance data from the Usolsky forests in the Krasnoyarsk region of central Siberia. Silkworm disturbance is expressed in this geo- database as a percentage of trees damaged or killed in a stand. The forest inventory data allows us to calculate a biomass estimate that will be compared to the biomass outputs generated by the model post insect disturbance. The validation of simulated biomass with independent inventory data confirms that FAREAST is a robust model of Russian forest dynamics. Effective validation of the insect disturbance model will allow us to generate a more complete picture of the changing ecology of the Siberian Boreal landscape. The economic cost of lumber lost as a result of Silkworm damage has been enormous, if verified, FAREAST will afford us the opportunity to estimate the extent of that loss and predict the changing ecological dynamics of the Boreal forest system under the worlds evolving climate.

  10. Microgravity can activate signals urging cells to S-phase entry during tissue and organ regeneration in Urodele amphibians exposed to real and simulated microgravity

    NASA Astrophysics Data System (ADS)

    Grigoryan, E.; Anton, H.-J.; Mitashov, V.

    Regenerative response following local injury or tissue removal in urodele amphibians is dependent on cell cycle entry of cells sources for regeneration in the remaining tissue. In a number of our experiments performed aboard biosatellites in orbital flights and fast rotated clinostat we found enhanced proliferative activity and, as a result, regeneration quicker than that in controls. In each investigated case an activity of cell proliferation evaluated by 3H-thymidine radioautography and BrdU assay at the early stages of lens, retina, forelimb and tail regeneration in newts was about 1,2-1,7 fold higher both under conditions of real and physiological weightlessness as compared with controls. Faster S-phase entry under conditions of micro- g was demonstrated by cycling multipotent cells as well as by differentiated postmitotic cells both participated in regeneration. Important, that cycling cells outside areas of regeneration were also found as displayed faster cellular growth. In our papers (1,2,3,4) we offered some hypothesis that could explain mechanisms of low g stimulating effect upon cell growth in regeneration in Urodela. In particular, changes in expression of some growth factors and their receptors, as well as the synthesis of specific range of generalized stress proteins (AGSPs) were proposed. However, in fact, molecular mechanisms of micro- g effect upon cell proliferation are mediated by changes on organismic level induced by micro- g environment. Some of them which are able to trigger off signaling changes on the cellular level that, in turn, evoke cells to grow faster would be represented in our report. 1. Mitashov V. et al. Adv. Space Res. 1996. 17 (6/7): 241-255 2. Anton H.-J. et al. Adv. Space Res. 1996. 17 (6/7): 55-65 3. Grigoryan E. et al. Adv. Space Res. 1998. 22 (2): 293-301 4. Grigoryan E. et al. Adv. Space Res. 2002. 30 (4): 757-764

  11. Involvement of the exomer complex in the polarized transport of Ena1 required for Saccharomyces cerevisiae survival against toxic cations.

    PubMed

    Anton, Carlos; Zanolari, Bettina; Arcones, Irene; Wang, Congwei; Mulet, Jose Miguel; Spang, Anne; Roncero, Cesar

    2017-12-01

    Exomer is an adaptor complex required for the direct transport of a selected number of cargoes from the trans -Golgi network (TGN) to the plasma membrane in Saccharomyces cerevisiae However, exomer mutants are highly sensitive to increased concentrations of alkali metal cations, a situation that remains unexplained by the lack of transport of any known cargoes. Here we identify several HAL genes that act as multicopy suppressors of this sensitivity and are connected to the reduced function of the sodium ATPase Ena1. Furthermore, we find that Ena1 is dependent on exomer function. Even though Ena1 can reach the plasma membrane independently of exomer, polarized delivery of Ena1 to the bud requires functional exomer. Moreover, exomer is required for full induction of Ena1 expression after cationic stress by facilitating the plasma membrane recruitment of the molecular machinery involved in Rim101 processing and activation of the RIM101 pathway in response to stress. Both the defective localization and the reduced levels of Ena1 contribute to the sensitivity of exomer mutants to alkali metal cations. Our work thus expands the spectrum of exomer-dependent proteins and provides a link to a more general role of exomer in TGN organization. © 2017 Anton et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  12. "No doubt this childhood disease on Vestmannö can be prevented"--neonatal tetanus on the Westman Islands.

    PubMed

    Jacobsen, Geir W; Hem, Erlend; Sigurdsson, Jóhann A

    2011-04-08

    At the beginning of the 1800 s neonatal tetanus was a major health hazard on the Westman Islands, an archipelago immediately south of Iceland. Up to 60–70% of newborn babies died in the course of the first two weeks of life, and Danish health authorities were almost helpless in the face of this mysterious disease. In 1847 the young Danish doctor Peter Anton Schleisner (1818-1900) was sent to the islands to investigate the conditions there. He established a maternity hospital, gave advice on hygiene and encouraged breast-feeding and a number of changes in diet. Since there was no known treatment, Schleisner's only option was to resort to preventive measures. He dressed the umbilical stump with balsamum copaivae and tried well-established methods such as opium tincture with saffron and mercurial ointment if there was any sign of infection. By the time he returned to Denmark after nine months, mortality had been halved. Neonatal mortality on the Westman Islands remained at the same low level throughout the rest of the 19th century. According to popular belief this was due to the naflaolian (navel oil) which Schleisner introduced. Nevertheless, it can be partly attributed to generally improved living standards, a relatively higher number of mothers in better social circumstances, a greater urban influence, changed lifestyle and hygienic measures. Schleisner's efforts are considered to have had major significance when conditions are compared with those on the Scottish island of St Kilda where the situation was the same and improved only just before the turn of the century.

  13. Correlation between Organic Matter Degradation and the Rheological Performance of Waste Sludge During Anaerobic Digestion

    NASA Astrophysics Data System (ADS)

    Morel, Evangelina S.; Hernández-Hernándes, José A.; Méndez-Contreras, Juan M.; Cantú-Lozano, Denis

    2008-07-01

    Anaerobic digestion has demonstrated to be a good possibility to reduce the organic matter contents in waste activated sludge resulting in the effluents treatment. An anaerobic digestion was carried out in a 3.5 L reactor at 35 °C for a period of 20 days. An electronic thermostat controlled the temperature. The reactor was agitated at a rate of 200 rpm. The study of the rheological behavior of the waste activated sludge was done with an Anton Paar™ rheometer model MCR301 with a peltier plate for temperature control. Four-blade vane geometry was used with samples of 37 mL for determining rheological properties. Sampling (two samples) was taken every four days of anaerobic digestion through a peristaltic pump. The samples behavior was characterized by the Herschel-Bulkley model, with R2>0.99 for most cases. In all samples were found an apparent viscosity (ηap) and yield stress (τo) decrement when organic matter content diminishes. This demonstrates a relationship between rheological properties and organic matter concentration (% volatile solids). Also the flow activation energy (Ea) was calculated using the Ahrrenius correlation and samples of waste activated sludge before anaerobic digestion. In this case, samples were run in the rheometer at 200 rpm and a temperature range of 25 to 75 °C with an increment rate of 2 °C per minute. The yield stress observed was in a range of 0.93-0.18 Pa, the apparent viscosity was in a range of 0.0358-0.0010 Pa.s, the reduction of organic matter was in a range of 62.57-58.43% volatile solids and the average flow activation energy was 1.71 Calṡg-mol-1.

  14. Energy landscape of LeuT from molecular simulations

    NASA Astrophysics Data System (ADS)

    Gur, Mert; Zomot, Elia; Cheng, Mary Hongying; Bahar, Ivet

    2015-12-01

    The bacterial sodium-coupled leucine transporter (LeuT) has been broadly used as a structural model for understanding the structure-dynamics-function of mammalian neurotransmitter transporters as well as other solute carriers that share the same fold (LeuT fold), as the first member of the family crystallographically resolved in multiple states: outward-facing open, outward-facing occluded, and inward-facing open. Yet, a complete picture of the energy landscape of (sub)states visited along the LeuT transport cycle has been elusive. In an attempt to visualize the conformational spectrum of LeuT, we performed extensive simulations of LeuT dimer dynamics in the presence of substrate (Ala or Leu) and co-transported Na+ ions, in explicit membrane and water. We used both conventional molecular dynamics (MD) simulations (with Anton supercomputing machine) and a recently introduced method, collective MD, that takes advantage of collective modes of motions predicted by the anisotropic network model. Free energy landscapes constructed based on ˜40 μs trajectories reveal multiple substates occluded to the extracellular (EC) and/or intracellular (IC) media, varying in the levels of exposure of LeuT to EC or IC vestibules. The IC-facing transmembrane (TM) helical segment TM1a shows an opening, albeit to a smaller extent and in a slightly different direction than that observed in the inward-facing open crystal structure. The study provides insights into the spectrum of conformational substates and paths accessible to LeuT and highlights the differences between Ala- and Leu-bound substates.

  15. [Medical cybernetics in Czechoslovakia--the first steps].

    PubMed

    Wünsch, Z

    1998-09-01

    During fifties there were at most few tens of persons in this country who believed in the future of computers and cybernetics. One group of such enthusiasts, headed by Antonín Svoboda, was working at a construction of the first Czech computer SAPO. The other group tried to analyse, anticipate, and prepare in advance various applications for the new systemic conceptions and for the information processing machines. Members of both groups met for discussions which opened prospects to the future and influenced many of other activities for a long time. At the early sixties, the Czechoslovak Cybernetic Society was established at the Czechoslovak Academy of Sciences and in 1962 the Main Problem Committee for the Medical Cybernetics was founded at the Department of Health. It coordinated majority of the research programmes in the medical cybernetics and informatics. In 1967-1969 the Committee prepared an extensive project of a medical information system (ZIS), but its accomplishment was finally blocked by the then authorities. However, interests for that topics kept growing and the new working places equipped with available computer technology were formed at the health and clinical centres. The first tentative lectures in medical cybernetics and biocybernetics at our faculty were introduced into the students curricula in the late sixties. Thematically, medical cybernetics subsequently differentiated into the medical informatics, simulations of biological and medical systems, and the biosignal analysis. The growing interest enabled to hold conferences since the middle of seventies, some of which were held periodically, sometimes with international participation. It is not possible in brevity to include the whole spectrum to those goal-directed activities nor to appraise adequately their future significance.

  16. Cosmic acceleration from a single fluid description

    NASA Astrophysics Data System (ADS)

    Capozziello, Salvatore; D'Agostino, Rocco; Luongo, Orlando

    2018-06-01

    We here propose a new class of barotropic factor for matter, motivated by properties of isotropic deformations of crystalline solids. Our approach is dubbed Anton-Schmidt's equation of state and provides a non-vanishing, albeit small, pressure term for matter. The corresponding pressure is thus proportional to the logarithm of universe's volume, i.e. to the density itself since V ∝ρ-1. In the context of solid state physics, we demonstrate that by only invoking standard matter with such a property, we are able to frame the universe speed up in a suitable way, without invoking a dark energy term by hand. Our model extends a recent class of dark energy paradigms named logotropic dark fluids and depends upon two free parameters, namely n and B. Within the Debye approximation, we find that n and B are related to the Grüneisen parameter and the bulk modulus of crystals. We thus show the main differences between our model and the logotropic scenario, and we highlight the most relevant properties of our new equation of state on the background cosmology. Discussions on both kinematics and dynamics of our new model have been presented. We demonstrate that the ΛCDM model is inside our approach, as limiting case. Comparisons with CPL parametrization have been also reported in the text. Finally, a Monte Carlo analysis on the most recent low-redshift cosmological data allowed us to place constraints on n and B. In particular, we found n = - 0 . 147-0.107+0.113 and B = 3.54 × 10-3.

  17. Energy landscape of LeuT from molecular simulations.

    PubMed

    Gur, Mert; Zomot, Elia; Cheng, Mary Hongying; Bahar, Ivet

    2015-12-28

    The bacterial sodium-coupled leucine transporter (LeuT) has been broadly used as a structural model for understanding the structure-dynamics-function of mammalian neurotransmitter transporters as well as other solute carriers that share the same fold (LeuT fold), as the first member of the family crystallographically resolved in multiple states: outward-facing open, outward-facing occluded, and inward-facing open. Yet, a complete picture of the energy landscape of (sub)states visited along the LeuT transport cycle has been elusive. In an attempt to visualize the conformational spectrum of LeuT, we performed extensive simulations of LeuT dimer dynamics in the presence of substrate (Ala or Leu) and co-transported Na(+) ions, in explicit membrane and water. We used both conventional molecular dynamics (MD) simulations (with Anton supercomputing machine) and a recently introduced method, collective MD, that takes advantage of collective modes of motions predicted by the anisotropic network model. Free energy landscapes constructed based on ∼40 μs trajectories reveal multiple substates occluded to the extracellular (EC) and/or intracellular (IC) media, varying in the levels of exposure of LeuT to EC or IC vestibules. The IC-facing transmembrane (TM) helical segment TM1a shows an opening, albeit to a smaller extent and in a slightly different direction than that observed in the inward-facing open crystal structure. The study provides insights into the spectrum of conformational substates and paths accessible to LeuT and highlights the differences between Ala- and Leu-bound substates.

  18. 75 FR 71648 - Federal Motor Vehicle Safety Standards, Child Restraint Systems; Hybrid III 10-Year-Old Child...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-24

    ...This document proposes to amend Federal Motor Vehicle Safety Standard (FMVSS) No. 213, Child Restraint Systems, regarding a Hybrid III 10-year-old child test dummy that the agency seeks to use in the compliance test procedures of the standard. This document supplements a 2005 notice of proposed rulemaking (NPRM) and a 2008 SNPRM previously published in this rulemaking (RIN 2127-AJ44) regarding this test dummy. In the 2005 NPRM, in response to Anton's Law, NHTSA proposed to adopt the 10-year-old child test dummy into FMVSS No. 213 to test child restraints for older children. Subsequently, to address variation that was found in dummy readings due to chin-to-chest contact, NHTSA published the 2008 SNPRM to propose a NHTSA-developed procedure for positioning the test dummy in belt-positioning seats. Comments on the SNPRM objected to the positioning procedure, and some suggested an alternative procedure developed by the University of Michigan Transportation Research Institute (UMTRI). Today's SNPRM proposes to use the UMTRI procedure to position the test dummy rather than the NHTSA-developed procedure. We note that the 10-year-old child dummy may sometimes experience stiff contact between its chin and upper sternal bib region which may result in an unrealistically high value of the head injury criterion (HIC) \\1\\ referenced in the standard. Accordingly, NHTSA proposes that the dummy's HIC measurement will not be used to assess the compliance of the tested child restraint. This SNPRM also proposes other amendments to FMVSS No. 213, including a proposal to permit NHTSA to use, at the manufacturer's option, the Hybrid II or Hybrid III versions of the 6-year-old test dummy, and a proposal to use the UMTRI procedure to position the Hybrid III 6-year- old and 10-year-old dummies when testing belt-positioning seats. ---------------------------------------------------------------------------

  19. PREFACE: 2nd International School and Conference Saint-Petersburg OPEN on Optoelectronics, Photonics, Engineering and Nanostructures (SPbOPEN2015)

    NASA Astrophysics Data System (ADS)

    2015-11-01

    The 2nd International School and Conference ''Saint Petersburg OPEN 2015'' on Optoelectronics, Photonics, Engineering and Nanostructures was held on April 6 - 8, 2015 at St. Petersburg Academic University. The School and Conference included a series of invited talks given by leading professors with the aim to introduce young scientists with actual problems and major advances in physics and technology. The keynote speakers were Mikhail V. Maximov (Ioffe Physico-Technical Institute RAS, Russia) Vladimir G. Dubrovskii (St. Petersburg Academic University and St. Petersburg State University, Russia) Anton Yu. Egorov (JSC Connector Optics, Russia) Victor V. Luchinin (St. Petersburg State Electrotechnical University, Russia) Vladislav E. Bugrov (St. Petersburg University of Internet Technologies, Mechanics and Optics, Russia) Vitali A. Schukin (VI Systems, Germany) Yuri P. Svirko (University of Eastern Finland, Finland) During the poster session all undergraduate and graduate students attending the conference presented their works. A sufficiently large number of participants, with more than 170 student attendees from all over the world, allowed the Conference to provide a fertile ground for fruitful discussions between the young scientists as well as to become a perfect platform for valuable discussions between student authors and highly experienced scientists. The best student papers, which were selected by the Program Committee and by the invited speakers basing on the theses and their poster presentation, were awarded with diplomas of the conference - see the photos. This year ''Saint Petersburg OPEN 2015'' is organized by St. Petersburg Academic University in cooperation with Peter the Great St. Petersburg Polytechnic University. The School and Conference is supported by Russian Science Foundation, SPIE (The International Society for Optics and Photonics), OSA (The Optical Society) and by Skolkovo Foundation. It is a continuation of the annual schools and seminars for

  20. Energy landscape of LeuT from molecular simulations

    PubMed Central

    Gur, Mert; Zomot, Elia; Cheng, Mary Hongying; Bahar, Ivet

    2015-01-01

    The bacterial sodium-coupled leucine transporter (LeuT) has been broadly used as a structural model for understanding the structure-dynamics-function of mammalian neurotransmitter transporters as well as other solute carriers that share the same fold (LeuT fold), as the first member of the family crystallographically resolved in multiple states: outward-facing open, outward-facing occluded, and inward-facing open. Yet, a complete picture of the energy landscape of (sub)states visited along the LeuT transport cycle has been elusive. In an attempt to visualize the conformational spectrum of LeuT, we performed extensive simulations of LeuT dimer dynamics in the presence of substrate (Ala or Leu) and co-transported Na+ ions, in explicit membrane and water. We used both conventional molecular dynamics (MD) simulations (with Anton supercomputing machine) and a recently introduced method, collective MD, that takes advantage of collective modes of motions predicted by the anisotropic network model. Free energy landscapes constructed based on ∼40 μs trajectories reveal multiple substates occluded to the extracellular (EC) and/or intracellular (IC) media, varying in the levels of exposure of LeuT to EC or IC vestibules. The IC-facing transmembrane (TM) helical segment TM1a shows an opening, albeit to a smaller extent and in a slightly different direction than that observed in the inward-facing open crystal structure. The study provides insights into the spectrum of conformational substates and paths accessible to LeuT and highlights the differences between Ala- and Leu-bound substates. PMID:26723619

  1. Elongational flow of polymer melts at constant strain rate, constant stress and constant force

    NASA Astrophysics Data System (ADS)

    Wagner, Manfred H.; Rolón-Garrido, Víctor H.

    2013-04-01

    Characterization of polymer melts in elongational flow is typically performed at constant elongational rate or rarely at constant tensile stress conditions. One of the disadvantages of these deformation modes is that they are hampered by the onset of "necking" instabilities according to the Considère criterion. Experiments at constant tensile force have been performed even more rarely, in spite of the fact that this deformation mode is free from necking instabilities and is of considerable industrial relevance as it is the correct analogue of steady fiber spinning. It is the objective of the present contribution to present for the first time a full experimental characterization of a long-chain branched polyethylene melt in elongational flow. Experiments were performed at constant elongation rate, constant tensile stress and constant tensile force by use of a Sentmanat Extensional Rheometer (SER) in combination with an Anton Paar MCR301 rotational rheometer. The accessible experimental window and experimental limitations are discussed. The experimental data are modelled by using the Wagner I model. Predictions of the steady-start elongational viscosity in constant strain rate and creep experiments are found to be identical, albeit only by extrapolation of the experimental data to Hencky strains of the order of 6. For constant stress experiments, a minimum in the strain rate and a corresponding maximum in the elongational viscosity is found at a Hencky strain of the order of 3, which, although larger than the steady-state value, follows roughly the general trend of the steady-state elongational viscosity. The constitutive analysis also reveals that constant tensile force experiments indicate a larger strain hardening potential than seen in constant elongation rate or constant tensile stress experiments. This may be indicative of the effect of necking under constant elongation rate or constant tensile stress conditions according to the Considère criterion.

  2. Observations of V420 Aur (HD 34921) needed to support spectroscopy

    NASA Astrophysics Data System (ADS)

    Waagen, Elizabeth O.

    2016-10-01

    Marcella Wijngaarden and Kelly Gourdji (graduate students at the University of Amsterdam/Anton Pannekoek Institute for Astronomy) have requested AAVSO observers' assistance in providing optical photometry of V420 Aur in support of their high-resolution spectroscopy with the Mercator telescope + Hermes spectrograph in La Palma 2016 October 7 through 17. They write: "[V420 Aur (HD 34921) is] the optical Be star that is part of a peculiar High Mass X-ray Binary...[that exhibits highly] complex and variable spectra...it is difficult to construct a physical model of this HMXB system, though based on these observations, the system is thought to contain a B[e] star with a dense plasma region, an accretion disk around a neutron star, a shell and circumstellar regions of cold dust. It has been over a decade since the last spectra were taken, and, given the highly variable nature of this star, we expect new observations to yield new information that will contribute to a better understanding of this system." Observations in BVRI (preferred over other bands) are requested beginning immediately and continuing through October 24. In all cases, timeseries in a few bands (i.e. BVRI) are preferred over single/a few observations in the other bands as it is the variability on relatively short timescales that is most important. "The target is bright so exposures should be long enough to reach good signal to noise in order to see the small variability amplitude but without saturating the target/comparison stars. We will study the variability on several timescales, so observations starting from a few per night to high cadence timeseries are useful." Finder charts with sequence may be created using the AAVSO Variable Star Plotter (https://www.aavso.org/vsp). Observations should be submitted to the AAVSO International Database. See full Alert Notice for more details.

  3. Changes in visual and sensory-motor resting-state functional connectivity support motor learning by observing

    PubMed Central

    McGregor, Heather R.

    2015-01-01

    Motor learning occurs not only through direct first-hand experience but also through observation (Mattar AA, Gribble PL. Neuron 46: 153–160, 2005). When observing the actions of others, we activate many of the same brain regions involved in performing those actions ourselves (Malfait N, Valyear KF, Culham JC, Anton JL, Brown LE, Gribble PL. J Cogn Neurosci 22: 1493–1503, 2010). Links between neural systems for vision and action have been reported in neurophysiological (Strafella AP, Paus T. Neuroreport 11: 2289–2292, 2000; Watkins KE, Strafella AP, Paus T. Neuropsychologia 41: 989–994, 2003), brain imaging (Buccino G, Binkofski F, Fink GR, Fadiga L, Fogassi L, Gallese V, Seitz RJ, Zilles K, Rizzolatti G, Freund HJ. Eur J Neurosci 13: 400–404, 2001; Iacoboni M, Woods RP, Brass M, Bekkering H, Mazziotta JC, Rizzolatti G. Science 286: 2526–2528, 1999), and eye tracking (Flanagan JR, Johansson RS. Nature 424: 769–771, 2003) studies. Here we used a force field learning paradigm coupled with resting-state fMRI to investigate the brain areas involved in motor learning by observing. We examined changes in resting-state functional connectivity (FC) after an observational learning task and found a network consisting of V5/MT, cerebellum, and primary motor and somatosensory cortices in which changes in FC were correlated with the amount of motor learning achieved through observation, as assessed behaviorally after resting-state fMRI scans. The observed FC changes in this network are not due to visual attention to motion or observation of movement errors but rather are specifically linked to motor learning. These results support the idea that brain networks linking action observation and motor control also facilitate motor learning. PMID:25995349

  4. All-Manganite Tunnel Junctions with Interface-Induced Barrier Magnetism

    NASA Astrophysics Data System (ADS)

    Sefrioui, Zouhair

    2011-03-01

    The recent discovery of several unexpected phases at complex oxide interfaces is providing new insights into the physics of strongly correlated electron systems. The possibility of tailoring the electronic structure of such interfaces has triggered a great technological drive to functionalize them into devices. In this communication, we describe an alternative strategy to produce spin filtering by inducing a ferromagnetic insulating state in an ultrathin antiferromagnetic layer in contact with a ferromagnetic layer. This artificially induced spin filtering persists up to relatively high temperatures and operates at high applied bias voltages. The results suggest that after playing a key role in exchange-bias for spin-valves, uncompensated moments at engineered antiferromagnetic interfaces represent a novel route for generating highly spin-polarized currents with antiferromagnets. Work done in collaboration with M. Bibes, C. Carrétéro, A. Barthélémy (Unité Mixte de Physique CNRS/Thales, Campus de Polytechnique, 1, Avenue A. Fresnel, 91767 Palaiseau (France) and Université Paris-Sud, 91045 Orsay (France)), F.A. Cuellar, C. Visani, A. Rivera-Calzada, , C. León, J. Santamaria (Grupo de Física de Materiales Complejos, Universidad Complutense de Madrid, 28040 Madrid (Spain)), M.J. Calderón, L. Brey (Instituto de Ciencia de Materiales de Madrid, CSIC, Cantoblanco, 28049 Madrid (Spain)), K. March, M. Walls, D. Imhoff (Laboratoire de Physique des Solides, CNRS, Université Paris-Sud, 91405 Orsay (France)), R. Lopez Anton, T.R. Charlton (ISIS, Rutherford Appleton Laboratory, Chilton, Oxon OX11 0QX (United Kingdom)), E. Iborra (Universidad Politécnica de Madrid, Escuela Técnica Superior de Ingenieros de Telecomunicaciones, 28040 Madrid (Spain)), F. Ott (Léon Brillouin, CEA/CNRS, UMR 12, 91191 Gif-sur-Yvette (France)). This work was supported by the Spanish Ministry for Science and Education programs MAT2008 06517, and the Réseau Thématique de Recherche Avanc

  5. [Electroconvulsive therapy and level of evidence: From causality to dose-effect relationship].

    PubMed

    Micoulaud-Franchi, J-A; Quilès, C; Cermolacce, M; Belzeaux, R; Adida, M; Fakra, E; Azorin, J-M

    2016-12-01

    The first objective of this article is to summarize the history of electroconvulsive therapy (ECT) in psychiatry in order to highlight the transition from clinical level of evidence based on phenomenological descriptions to controlled trial establishing causal relationship. The second objective is to apply the criteria of causation for ECT, to focus on the dose-effect relationship criteria, and thus to analyze the conditions of application of these criteria for ECT. A literature review exploring the use of electricity, ECT and electroencephalography (EEG) in psychiatry was conducted. The publications were identified from the Pubmed and GoogleScholar electronic databases. The scientific literature search of international articles was performed in July 2016. In 1784, a Royal commission established in France by King Louis XVI tested Mesmer's claims concerning animal magnetism. By doing that, the commission, including such prominent scientists as the chemist Anton Lavoisier and the scientist and researcher on electricity and therapeutics Benjamin Franklin, played a central role in establishing the criteria needed to assess the level of evidence of electrical therapeutics in psychiatry. Surprisingly, it is possible to identify the classical Bradford Hill criteria of causation in the report of the commission, except the dose-effect relationship criteria. Since then, it has been conducted blinded randomized controlled trials that confirmed the effectiveness of ECT against ECT placebos for the treatment of psychiatric disorders. At present, the dose-effect relationship criteria can be analyzed through an EEG quality assessment of ECT-induced seizures. EEG quality assessment includes several indices: TSLOW (time to onset of seizure activity ≤5Hz, seconds), peak mid-ictal amplitude (mm), regularity (intensity or morphology of the seizure (0-6)), stereotypy (global seizure patterning, 0-3) and post-ictal suppression (0-3). A manual rating sheet is needed to score theses

  6. The update of resist outgas testing for metal containing resists at EIDEC

    NASA Astrophysics Data System (ADS)

    Shiobara, Eishi; Mikami, Shinji

    2017-10-01

    work was supported by Ministry of Economy, Trade and Industry (METI) and New Energy and Industrial Technology Development Organization (NEDO). [1] Eishi Shiobara, Shinji Mikami, Satoshi Tanaka, International Symposium on EUV Lithography, Hiroshima, Japan, P-RE-01, (2016). [2] Mark van de Kerkhof, Hans Jasper, Leon Levasier, Rudy Peeters, Roderik van Es, Jan-Willem Bosker, Alexander Zdravkov, Egbert Lenderink, Fabrizio Evangelista, Par Broman, Bartosz Bilski, Thorsten Last, Proc. of SPIE Vol. 10143, 101430D (2017). [3] Oktay Yildirim, Elizabeth Buitrago, Rik Hoefnagels, Marieke Meeuwissen, Sander Wuister, Gijsbert Rispens, Anton van Oosten, Paul Derks, Jo Finders, Michaela Vockenhuber, Yasin Ekinci, Proc. of SPIE Vol. 10143, 101430Q (2017).

  7. Shear thinning behaviors in magmas

    NASA Astrophysics Data System (ADS)

    Vetere, F. P.; Cassetta, M.; Perugini, D.

    2017-12-01

    Studies on magma rheology are of fundamental importance to understanding magmatic processes from depth to surface. Since viscosity is one of the most important parameter controlling eruption mechanisms, as well as lava flow emplacement, a comprehensive knowledge on the evolution of magma viscosities during crystallization is required. We present new viscosity data on partly crystalized basalt, andesite and analogue lavas comparable to those erupted on Mercury's northern volcanic plains. High-temperature viscosity measurements were performed using a rotational Anton Paar RheolabQC viscometer head at the PVRG labs, in Perugia (Italy) (http://pvrg.unipg.it). The relative proportion of phases in each experimental run were determined by image analysis on BS-SEM images at different magnifications; phases are glasses, clinopyroxene, spinel, plagioclase for the basalt, plagioclase and spinel for the andesite and pure enstatite and clinopyroxenes, for the analogue Mercury's composition. Glass and crystalline fractions determined by image analysis well correlate with compositions of residual melts. In order to constrain the viscosity (η) variations as a function of crystallinity, shear rate (γ) was varied from 0.1 to 5 s-1. Viscosity vs. time at constant temperature shows a typical S-shape curve. In particular, for basaltic composition η vary from 3.1-3.8 Pa s [log η] at 1493 K and crystallinity of 19 area % as γ vary from 1.0 to 0.1 s-1; the andesite viscosity evolution is 3.2 and 3.7 Pa s [log η] as γ varies from 1 to 0.1 at 1493 K and crystal content of 17 area %; finally, Mercury's analogue composition was investigated at different temperature ranging from 1533 to 1502 K (Vetere et al., 2017). Results, for γ = 0.1, 1.0 and 5.0 s-1, show viscosity variation between 2.7-4.0, 2.5-3.4 and 2.0-3.0 [log η inPa s] respectively while crystallinity vary from 9 to 27 (area %). As viscosity decreases as shear rate increases, these data points to a shear thinning behaviour

  8. Maribor General Hospital from its foundation until World War II.

    PubMed

    Pivec, Gregor

    2006-01-01

    The author describes the history of Maribor General Hospital from its foundation in 1799 until the beginning of World War II. In 1799 the magistrate of the town of Maribor issued a memorandum regarding the establishment of a town hospital in the renovated building of the town hospice, providing space for 24 patients. The work of the hospital was carried out in the former hospice building until 1855. In the period between its establishment and eventual relocation 26 beds were added. The last two decades of the hospital's operation at the original location were marked by the assiduous work of the town's physicist, Dr. Anton Kuker. In the first half of the 19th century, the population of Maribor grew rapidly as a consequence of the construction of the Southern Railway. The town authorities therefore purchased the Prosenjak family villa in the Magdalena suburbs and relocated the hospital to it in 1855, providing 28 rooms for 110 patients. For a whole century, the care of patients was taken over by the Daughters of Charity of Saint Vincent de Paul. The hospital was soon admitting over 1000 patients a year, the most common complaints being pulmonary catarrh, gastritis and fever. In 1872, when the Master of Surgery Feliks Ferk joined the hospital, the internal "medical" and the "external" surgical departments were formed. Although medical studies were not easily accessible, there were a number of Slovene physicians working in the hospital and the town in that period. In the last decades of the 19th century, the hospital was often renovated and enlarged. The infrastructure (telephone, water supply system, heating, lighting) had also been modernized before World War I. In 1914, the first X-ray apparatus was purchased. Between the wars, the hospital's development was boosted by recruitment of the Slovene physicians Ivan Matko, Mirko Cernic, Janko Dernovsek and Hugon Robic. The initial external and medical departments split into several departments: internal medicine, surgery

  9. Viscosity of carbonate-rich melts under different oxygen fugacity conditions

    NASA Astrophysics Data System (ADS)

    Di Genova, Danilo; Hess, Kai-Uwe; Cimarelli, Corrado; Dingwell, Donald B.

    2015-04-01

    Viscosity is a fundamental property of many materials and its changes affects the fluid dynamics of natural system as well as industrial processes. The mobility of carbonatitic melts, which are carbonate-rich and very fluid melts, has attracted renewed interest in both earth science and industry. In fact, these melts are considered the main transport agent of carbon from the mantle to the crust and may be intimately linked to the generation of kimberlites. At the same time lithium, potassium and sodium carbonate are used as electrolytes in molten carbonate fuel cells which operate at high temperatures (~650° C) for the production of electricity without CO2 emissions. Accurate measurement of the transport property (i.e. viscosity) of carbonatitic melts is a priority in order to understand the carbonatite mobility and reaction rates. Additionally, obtaining accurate viscosity measurements of such low viscosity melts is however an experimental challenge due to volatility, very low torques and chemical melt instability in the viscometer. To overcome these limitations we have customized a Modular Compact Rheometer (MCR 502 from Anton Paar) ad hoc equipped with 2 narrow gap concentric-cylinder geometries of steel and Pt-Au. The rheometer is characterized by an air-bearing-supported synchronous motor with torque ranging between 0.01 μNm and 230 mNm (resolution of 0.1 nNm), achieving very low viscosity measurements in the order of mPa s, temperatures up to 1000° C and shear rates ranging between 1 and 100 sec-1. These experimental conditions well match the temperature-viscosity-shear rate window relevant for carbonate melts. Here we present the calibration of the rheometer and the results of a rheological characterization study on a series of very low viscous synthetic and natural carbonatitic melts at different oxygen fugacity (air and CO2 saturated atmosphere). Viscosity measurements on carbonate melts have been performed in the temperature range between ~650 and 1000

  10. Perspective View with Color-Coded Shaded Relief, Central Panama

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This perspective view shows central Panama, with the remnants of the extinct volcano El Valle in the foreground and the Caribbean Sea in the distance. El Valle underwent an explosive eruption about 3 million years ago, forming a crater 5 kilometers (3.1 miles) across, one of the largest in the Americas. The crater subsequently filled with water forming a huge lake, but about 12,000 years ago a breach at the present site of the waterfall Choro de las Mozas caused it to drain, forming the present valley. Within the crater is the town of El Valle de Anton, whose 600-meter (1,968-foot) elevation and resulting cooler climate make it a popular tourist and vacation site.

    The lake in the distance is Lake Gatun, at the west end of the Panama Canal. The canal itself extends to the southwest (to the right in this northeast facing view) but is hidden by the intervening terrain.

    This shaded relief perspective view was generated using topographic data from the Shuttle Radar Topography Mission (SRTM). A computer-generated artificial light source illuminates the elevation data to produce a pattern of light and shadows. Slopes facing the light appear bright, while those facing away are shaded. On flatter surfaces, the pattern of light and shadows can reveal subtle features in the terrain. Colors show the elevation as measured by SRTM, and range from green at the lowest elevations to white at the highest elevations.

    SRTM, launched on February 11, 2000, uses the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. The mission is designed to collect three-dimensional measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter-long (200-foot) mast, an additional C-band imaging antenna and improved tracking and navigation devices. The mission is a cooperative project between NASA, the National Imagery and Mapping Agency (NIMA) and the

  11. Deriving Equations of State for Specific Lakes and Inland Seas from Laboratory Measurements

    NASA Astrophysics Data System (ADS)

    Andrulionis, Natalia; Zavialov, Ivan; Zavialov, Peter; Osadchiev, Alexander; Kolokolova, Alexandra; Alukaeva, Alevtina; Izhitskiy, Alexander; Izhitskaya, Elena

    2017-04-01

    The equation of state is the dependence of water density on temperature, salinity, and pressure. It is important in many respects, in particular, for numerical modeling of marine systems. The widely used UNESCO equation of state, as well as the more recent and general TEOS-10 equation, are intended for the ocean waters. Hence, they are confined to salinities below 40 ‰ and, even more restrictively, valid only for ionic salt composition characteristic for the ocean. Both conditions do not hold for many lakes. Moreover, significant deviations of the ionic composition from the oceanic one have been documented for coastal zones, especially those exposed to river discharges. Therefore, the objective of this study was to find equations of state for areas or water bodies with non-oceanic ionic salt composition. In order to obtain the required equations, we analyzed water samples obtained in expeditions of 2014-2016 from the Black Sea, the Aral Sea, Lake Issyk-Kul and Caspian Sea. The filtered samples were submitted to high accuracy (up to 0.00001 g/cm3) density measurements in laboratory using the Anton Paar DMA 5000M in the temperature range from 1 to 29°C. The absolute salinity values of the initial samples were obtained through the dry residue method. Further, we diluted the samples by purified deionized water to produce different salinities. To control the accuracy of the dilution process, we used a reference sample of standard IAPSO-certified seawater at 35‰. The density versus salinity and temperature data obtained thereby were then approximated by a best fitting 2-order polynomial surface using the least squares method. This procedure yielded the approximate empirical equations of state for the selected marine areas (the Russian Black Sea shelf) and inland water bodies (the Aral Sea, the Lake Issyk-Kul, the Caspian Sea). The newly derived equations - even the one for the Black Sea shelf - are different from the oceanic equation significantly within the

  12. Local Heroes Live!

    NASA Astrophysics Data System (ADS)

    1999-09-01

    Physics teacher Andrew Morrison from High Pavement College in Nottingham has recently been appointed as Schools' officer for particle physics by the Particle Physics and Astronomy Research Council, as part of the Council's Public Understanding of Science programme. As well as his role as an experienced physics teacher, Andrew has acted as marketing manager for his college and chair of the Nottinghamshire section of the Association for Science Education. He will now be working two days each week in his new role with PPARC, acting as a link between the science education and research communities, helping researchers develop ideas for promoting particle physics and leading some specific new projects for the production of schools materials. Andrew can be contacted at High Pavement Sixth Form College, Gainsford Crescent, Nottingham NG5 5HT (tel: 0115 916 6165 or e-mail: morrison@innotts.co.uk). On the other side of the Atlantic, an 18 year-old student at Atlee High School in Mechanicsville, Virginia, USA was the recipient of the `1999 Young Scientist of the Year' award. Jakob Harmon submitted a project on magnetic levitation (maglev) in this extracurricular competition organized by PhysLINK.com, a leading Internet authority on physics and engineering education. The prize was a summer placement at Virginia Polytechnic Institute, Blacksburg, where Jakob continued his education in one of the most active maglev research and development groups in the USA. He also received science books and software as part of the award. The PhysLINK.com award was established to recognize, encourage and foster talented high school students in physics and engineering, with the prize being designed to fit the specific needs and aspirations of each individual winner. Details of next year's competition, along with Jakob's project and more about magnetic levitation can be viewed at www.physlink.com or by contacting Anton Skorucak of PhysLINK.com at 11271 Ventura Blvd #299, Studio City, CA 91606

  13. Possible changes in ground-water flow to the Pecos River caused by Santa Rosa Lake, Guadalupe County, New Mexico

    Risser, D.W.

    1987-01-01

    In 1980 Santa Rosa Dam began impounding water on the Pecos River about 7 miles north of Santa Rosa, New Mexico, to provide flood control, sediment control, and storage for irrigation. Santa Rosa Lake has caused changes in the groundwater flow system, which may cause changes in the streamflow of the Pecos River that cannot be detected at the present streamflow gaging stations. Data collected at these stations are used to measure the amount of water available for downstream users. A three-dimensional groundwater flow model for a 950 sq mi area between Anton Chico and Puerto de Luna was used to simulate the effects of Santa Rosa Lake on groundwater flow to a gaining reach of the Pecos River for lake levels of 4,675, 4,715, 4,725, 4,750, 4,776, and 4,797 feet above sea level and durations of impoundment of 30, 90, 182, and 365 days for all levels except 4 ,797 feet. These simulations indicated that streamflow in the Pecos River could increase by as much as 2 cu ft/sec between the dam and Puerto de Luna if the lake level were maintained at 4 ,797 feet for 90 days or 4,776 feet for 1 year. About 90% of this increased streamflow would occur < 0.5 mi downstream from the dam, some of which would be measured at the streamflow gaging station located 0.2 mile downstream from the dam. Simulations also indicated that the lake will affect groundwater flow such that inflow to the study area may be decreased by as much as 1.9 cu ft/sec. This water may leave the Pecos River drainage basin or be diverted back to the Pecos River downstream from the gaging station near Puerto de Luna. In either case, this quantity represents a net loss of water upstream from Puerto de Luna. Most simulations indicated that the decrease in groundwater flow into the study area would be of about the same quantity as the simulated increase in streamflow downstream from the dam. Therefore, the net effect of the lake on the flow of the Pecos River in the study area appears to be negligible. Model simulations

  14. The Physicist and Astronomer Christoper Scheiner - Biography Letters, Works

    NASA Astrophysics Data System (ADS)

    Daxecker, Franz

    The Jesuit priest Christopher Scheiner was one of the most influential astronomers of the first half of the 17th century. He was a creative and down-to-earth natural scientist who worked in the fields of astronomy, physics, optics and ophthalmology, while following his vocations as university lecturer, church builder and pastor. In scientific matters he was Galilei's opponent. Their dispute centred on the priority of discovery in regard to the sunspots. Scheiner was not the first to discover the sunspots, but he gave the most detailed account thereofin his main work "Rosa Ursina sive Sol". He was, however, ceaseless in his defense of the geocentric system. In 1891, Anton v.Braunmühl published a biography of Father Scheiner. Ever since then, new documents have come to light, justifying the publication of a new biography. Among the documents now available is Scheiner's hitherto unknown dissertation. Notes taken during his lectures in Ingolstadt provide valuable information on astronomy using the telescope, an invention of his lifetime. His exchange of letters with personalities like Archduke Leopold V of Austria-Tyrol, with scientists like Magini, Galilei, Gassendi, Kepler and confriars Rader, Guldin, Alber, Minutuli, Cysat und Kircher is a source of precious insights. Letters to Scheiner from the Father Generals of his order display evidence of his superiors' zero tolerance for the helincentric system. They also disclose Scheiner's wish to become a missionary in China, the financial difficulties he faced while trying to find a publisher for his "Rosa Ursina sive Sol" and his personal shortcomings. A Scheiner obituary from 1650 was found in Cracow in 2001. It contains information on the troublesome last years of his life and has finally allowed us to determine the year of his birth. Scheiner's personality has been praised as well as criticized by many authors - sometimes depending on their ideological backgrounds. This holds true especially regarding the argument

  15. Viral Hepatitis Strategic Information to Achieve Elimination by 2030: Key Elements for HIV Program Managers.

    PubMed

    Hutin, Yvan; Low-Beer, Daniel; Bergeri, Isabel; Hess, Sarah; Garcia-Calleja, Jesus Maria; Hayashi, Chika; Mozalevskis, Antons; Rinder Stengaard, Annemarie; Sabin, Keith; Harmanci, Hande; Bulterys, Marc

    2017-12-15

    Yvan Hutin, Daniel Low-Beer, Isabel Bergeri, Sarah Hess, Jesus Maria Garcia-Calleja, Chika Hayashi, Antons Mozalevskis, Annemarie Rinder Stengaard, Keith Sabin, Hande Harmanci, Marc Bulterys. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 15.12.2017.

  16. VizieR Online Data Catalog: The Initial Gaia Source List (IGSL) (Smart, 2013)

    NASA Astrophysics Data System (ADS)

    Smart, R. L.; Nicastro, L.

    2013-11-01

    The IGSL is a compilation catalog produced for the Gaia mission. We have combined data from the following catalogs or datasets to produce a homogenous list of positons, proper motions, photometry in a blue and red band and estimates of the magnitudes in the Gaia G and G_RVS bands. Included Catalogs: Tycho2, LQRF, UCAC4, SDSS-DR9, PPMXL, GSC23, GEPC, OGLE, Sky2000, 2MASS. Note that in compiling the various entries we did not consider the individual flags. Overall, we think this catalog is reliable but there will be errors, mismatches and duplicates. The user should use this catalog with that in mind, it is fine for statistical studies that has some way to remove obviously incorrect entries but it should only be used with care for individual objects. The source catalogs used to produce the IGSL are: * The Gaia Ecliptic Pole Catalog, version 3.0 (GEPC) Altmann & Bastian 2009, "Ecliptic Poles Catalogue Version 1.1" ESA Document GAIA-C3-TN-ARI-MA-002 URL http://www.rssd.esa.int/llink/livelink/open/2885828 * GSC2.3: GSC2 version 2.3, Lasker et al. 2008AJ....136..735L (I/305) * an excerpt of the 4th version of the Gaia Initial QSO Catalog (GIQC) as compiled by the GWP-S-335-13000, formed by Alexandre H. Andrei, Christophe Barache, Dario N. da Silva Neto, Francois Taris, Geraldine Bourda, Jean-Francois Le Campion, Jean Souchay, J.J. Pereira Osorio, Julio I. Bueno de Camargo, Marcelo Assafin, Roberto Vieira Martins, Sebastien Bouquillon, Sebastien Lambert, Sonia Anton, Patrick Charlot * OGLE: Optical Gravitational Lensing Experiment version III (Szymaski et al., 2011, Cat. J/AcA/61/83) * PPMXL: Positions and Proper Motions "Extra Large" Catalog, Roeser et al. (2010, Cat. I/317) * SDSS: Sloan Digital Sky Survey data release 9, Cat. V/139 * UCAC4: Zacharias et al., 2012, Cat. I/322 * Tycho-2, Hoeg et al., 2000, Cat. I/259 (1 data file).

  17. Music and the Nature: Input of the Czech Composers

    NASA Astrophysics Data System (ADS)

    Nemec, Vaclav; Nemcova, Lidmila

    2014-05-01

    Extraordinary occasions for art of any kind - music, creative graphic and plastic arts, literature (classic, modern incl. science fiction), theatre, cinema, etc. - exist to harmonise individual personal interests with those of the humanity well-being and of the Nature and also to cultivate individual spirituality and the appropriate values. Arts can be applied as irreplaceable means for making any human being better, for improving his sense for solidarity and for increasing his ethical sensibility. An interest for the art should be cultivated already since the childhood. - How much of inspiration for numerous composers all over the world has been given by the Nature, how much of inspiration for people who by listening to such a music are increasing nobility of their behaviour as well as their friendly approach to the Nature. - Many classical music works have been written with a strong inspiration by the Nature itself from the past until today. The actual Year of the Czech Music gives the possibility to present the most famous Czech composers inspired by the Nature (selected examples only): Bedřich Smetana (1824 - 1884): At the sea shore - a concert etude for piano inspired by his stay in Göteborg (Sweden); Vltava (Moldau) - a symphonic poem from the cycle "My country" inspired by the river crossing Bohemia from the South to Prague; From the Bohemian woods and meadows - another symphonic poem from the same cycle. Antonín Dvořák (1841 - 1904): V přírodě (In the Nature) - a work for orchestra Leoš Janáček (1854 - 1928): Příhody li\\vsky Bystrou\\vsky (The Cunning Little Vixen) - an opera situated mostly in a forest. Josef Bohuslav Foerster (1859-1951): Velké širé rodné lány (Big large native fields) - a choir for men singers inspired by the nature in the region where the composer as a boy from Prague was visiting his grand-father. Vítězslav Novák (1870 - 1949): In Tatra mountains - a symphonic poem expressing the author's passion for the famous

  18. [Mental disease in two classical music composers].

    PubMed

    Rempelakos, L; Poulakou-Rebelakou, E; Ploumpidis, D

    2012-01-01

    A study οn two neglected classical music composers suffering a not syphilitic mental disease, is attempted here, syphilis of the central nervous system being frequent in that time. A brief overview on the psychiatric ailments of many great composers reveals suicide attempts and more or less severe depression following external events. The issue of a possible relationship between mental disease and (musical) creativity can be discussed, as mood swings and a certain tendency to melancholia are frequent features of a talented brain (a fact that can also be detected in their works). The first case presented here is Hans Rott from Austria, the beloved student of Anton Bruckner, who was considered to be at least equal to his famous classmate Gustav Mahler. The great expectations of his teacher and his friends suddenly came to an end, when he suffered a crisis of schizophrenia and was hospitalized in an insane asylum in Lower Austria. The tragic psychiatric adventure of the young musician lasted almost four years. He was diagnosed as a case of "hallucinatory insanity" and "persecution mania" by the medical staff, before dying of tuberculosis, aged only 26, and having completed only one symphony and several smaller works. His name came again on surface only a century after his death, when in 1989 his Symphony in E Major was discovered and premiered with great success, permitting to its creator a posthumous recognition, among Bruckner and Mahler. The second case of mental illness is that of the Armenian Komitas Vardapet. He was an orphan who grew up in theological schools and became a monk and later a priest, though he spent some years in Berlin in order to develop his musical skills. He is considered to be an authority of Armenian ecclesiastic music, introducing polyphony in the Armenian Church's music and collecting numerous traditional songs from all parts of Armenia. In 1915, during the Armenian genocide he was deported, tortured but finally saved, due to interventions

  19. Kinematics of an oblique deformation front using paleomagnetic data; the Altomira-Loranca structures (Iberian Chain, Central Spain)

    NASA Astrophysics Data System (ADS)

    Valcarcel, M.

    2013-05-01

    Manoel Valcárcel1, 5, Ruth Soto2, Elisabet Beamud3, Belén Oliva-Urcia4 and Josep Anton Muñoz5 1 IGME, Departamento de Investigación y Prospección Geocientífica. C/ La Calera, 1, 28760 Tres Cantos; m.valcarcel@igme.es 2 IGME, Unidad de Zaragoza, C/ Manuel Lasala 44, 9 B, 50006 Zaragoza, Spain 3 Lab. Paleomagnetisme (CCiT UB-CSIC). ICT "Jaume Almera", Solé i Sabarís, s/n, 08028 Barcelona, Spain. 4 IPE-CSIC, Avda. Montañana 1005, 50059 Zaragoza, Spain 5 Grup Geodinàmica i Anàlisi de Conques, Universitat de Barcelona, Zona Universitària Pedralbes, 08028 Barcelona, Spain The Altomira and Loranca structures consist of a fold-and-thrust system detached on Triassic evaporites. They are oriented N-S to NNE-SSW and NNW-SSE at its northern and southern end, respectively, forming a subtle arc, oblique with respect to the general NW-SE trend of the Iberian Chain. The aim of this work is to characterize with paleomagnetic data the kinematic evolution of the the Altomira Range, located at the southwestern deformation front of the Iberian Chain, and of the structures within its associated piggy-back basin, the Loranca basin. This approach will also give clues regarding the primary and/or secondary origin of these structures to better characterize them in further studies (3D reconstruction and restoration, fault pattern). A total of 180 samples were obtained from 19 sites in Eocene, Oligocene and Miocene rocks (including clays, fine sandstones and limestones). They were analyzed by means of stepwise thermal demagnetization and subsequent measurement of the natural remanent magnetization (NRM). Although fold tests are not statistically significant, a primary origin of the magnetization is deduced by samples showing either normal or reverse polarity after bedding correction of the calculated characteristic components. Declinations of the site mean directions appear scattered after bedding correction suggesting differential vertical-axis rotations. Sites located at the

  20. NVP melt/magma viscosity: insight on Mercury lava flows

    NASA Astrophysics Data System (ADS)

    Rossi, Stefano; Morgavi, Daniele; Namur, Olivier; Vetere, Francesco; Perugini, Diego; Mancinelli, Paolo; Pauselli, Cristina

    2016-04-01

    After more than four years of orbiting Mercury, NASA's MESSENGER spacecraft came to an end in late April 2015. MESSENGER has provided many new and surprising results. This session will again highlight the latest results on Mercury based on MESSENGER observations or updated modelling. The session will further address instrument calibration and science performance both retrospective on MESSENGER and on the ESA/JAXA BepiColombo mission. Papers covering additional themes related to Mercury are also welcomed. Please be aware that this session will be held as a PICO session. This will allow an intensive exchange of expertise and experience between the individual instruments and mission. NVP melt/magma viscosity: insight on Mercury lava flows S. Rossi1, D. Morgavi1, O. Namur2, D. Perugini1, F.Vetere1, P. Mancinelli1 and C. Pauselli1 1 Dipartimento di Fisica e Geologia, Università di Perugia, piazza Università 1, 06123 Perugia, Italy 2 Uni Hannover Institut für Mineralogie, Leibniz Universität Hannover, Callinstraβe 3, 30167 Hannover, Germany In this contribution we report new measurements of viscosity of synthetic komatitic melts, used the behaviour of silicate melts erupted at the surface of Mercury. Composition of Mercurian surface magmas was calculated using the most recent maps produced from MESSENGER XRS data (Weider et al., 2015). We focused on the northern hemisphere (Northern Volcanic Province, NVP, the largest lava flow on Mercury and possibly in the Solar System) for which the spatial resolution of MESSENGER measurements is high and individual maps of Mg/Si, Ca/Si, Al/Si and S/Si were combined. The experimental starting material contains high Na2O content (≈7 wt.%) that strongly influences viscosity. High temperature viscosity measurements were carried out at 1 atm using a concentric cylinder apparatus equipped with an Anton Paar RheolabQC viscometer head at the Department of Physics and Geology (PVRG_lab) at the University of Perugia (Perugia, Italy

  1. Giovanni Verga (1879-1923), author of a pioneering treatise on pituitary surgery: the foundations of this new field in Europe in the early 1900s.

    PubMed

    Pascual, José M; Mongardi, Lorenzo; Prieto, Ruth; Castro-Dufourny, Inés; Rosdolsky, María; Strauss, Sewan; Carrasco, Rodrigo; Winter, Eduard; Mazzarello, Paolo

    2017-10-01

    The field of pituitary surgery was born in the first decade of the twentieth century in Europe, and it evolved rapidly with the development of numerous innovative surgical techniques by some of the founding fathers of neurosurgery. This study investigates the pioneering Italian treatise on pituitary surgery, La Patologia Chirurgica dell'Ipofisi (Surgical Pathology of the Hypophysis), published in 1911 by Giovanni Verga (1879-1923), a surgeon from Pavía and one of Golgi's disciples. This little-known monograph compiles the earliest experience on pituitary surgery through the analysis of the first 50 procedures performed between 1903 and 1911. We conducted a biographical survey of Giovanni Verga and the motivations for his work on pituitary surgery. In addition, a systematic analysis of all original reports and historical documents about these pituitary procedures referenced in Verga's treatise was carried out. Verga's treatise provides a summary of the techniques employed and surgical outcomes for the first 50 attempted procedures of pituitary tumor removal. This monograph is the only scientific source that includes a complete account of the series of 10 pituitary tumors operated on by Sir Victor Horsley in the 1900s. Three major types of surgery were employed: (i) palliative procedures of craniectomy (n = 6); (ii) transcranial approaches to the pituitary gland, either subfrontal or subtemporal (n = 13); and (iii) transphenoidal routes to expose the sella turcica, either using an upper transnasal-transethmoidal approach (n = 19) or a lower sublabial/endonasal-transeptal one (n = 12). An operative mortality rate of 36% (n = 17) was observed in these early series. The pathological nature of the tumors operated on was available in 42 cases. There were 28 adenomas and 15 craniopharyngiomas. Sir Victor Horsley (1857-1916) and the Viennese surgeons Anton von Eiselsberg (1860-1939) and Oskar Hirsch (1877-1965) were the leading European figures in the development

  2. The missing graphical user interface for genomics.

    PubMed

    Schatz, Michael C

    2010-01-01

    The Galaxy package empowers regular users to perform rich DNA sequence analysis through a much-needed and user-friendly graphical web interface. See research article http://genomebiology.com/2010/11/8/R86 RESEARCH HIGHLIGHT: With the advent of affordable and high-throughput DNA sequencing, sequencing is becoming an essential component in nearly every genetics lab. These data are being generated to probe sequence variations, to understand transcribed, regulated or methylated DNA elements, and to explore a host of other biological features across the tree of life and across a range of environments and conditions. Given this deluge of data, novices and experts alike are facing the daunting challenge of trying to analyze the raw sequence data computationally. With so many tools available and so many assays to analyze, how can one be expected to stay current with the state of the art? How can one be expected to learn to use each tool and construct robust end-to-end analysis pipelines, all while ensuring that input formats, command-line options, sequence databases and program libraries are set correctly? Finally, once the analysis is complete, how does one ensure the results are reproducible and transparent for others to scrutinize and study?In an article published in Genome Biology, Jeremy Goecks, Anton Nekrutenko, James Taylor and the rest of the Galaxy Team (Goecks et al. 1) make a great advance towards resolving these critical questions with the latest update to their Galaxy Project. The ambitious goal of Galaxy is to empower regular users to carry out their own computational analysis without having to be an expert in computational biology or computer science. Galaxy adds a desperately needed graphical user interface to genomics research, making data analysis universally accessible in a web browser, and freeing users from the minutiae of archaic command-line parameters, data formats and scripting languages. Data inputs and computational steps are selected from

  3. Müller cell gliotic response in the retina of the newts exposed to real and simulated microgravity

    NASA Astrophysics Data System (ADS)

    Grigoryan, Eleonora N.; Poplinskaya, Valentina; Domaratskaya; Aleinikova, Karina; Novikova, Julia; Anton, Hermann J.; Almeida, Eduardo

    The effects of real and simulated microgravity on the eye tissue regeneration of newts (Pl. waltli) after lens and/or retina removal were investigated. Changes in Müller glial cells in the retina of eyes regenerating after lens extirpation were detected in newts exposed to clinostat-ing. The cells were hypertrophied, and their processes thickened. Such changes were viewed as specific of reactive gliosis [1]. Later experiments onboard the Russian biosatellite Bion-11 showed similar changes in the retinas of newts regenerating after a two-week spaceflight. In the Bion-11 animals, GFAP, the major structural protein of macroglial cells was found to be up-regulated [2]. In more recent experiments onboard Foton-2 (2005) and Foton-M3 (2007), GFAP expression in retinas of space-flown, ground control (kept at 1 g), and basal control (sacrificed on launch day) newts was quantified, using microscopy, immunohistochemistry, and digital image analysis. It was found that Müller cell processes of non-operated animals dis-u played low GFAP immunolabeling. A low level of immunoreactivity was also observed in basal controls. In contrast, retinas of space-flown animals showed greater GFAP immunoreactivity associated with both an increased cell number and a higher density of intermediate filaments [3]. This, in turn, was accompanied by up-regulation of stress protein (HSP90) and growth factor (FGF2) expressions. It can be postulated that such a response of Müller cells was to mitigate the retinal stress in newts exposed to microgravity. Although the exact mechanisms remain unknown, it can be hypothesized that GFAP up-regulation is mediated by HSPs and growth factors, particularly by FGF2. Taken together, these data suggest that the retinal population of macroglial cells is sensitive to gravity changes and that in space it can react by enhancing its neuroprotective function. [1] Grigoryan E.N., Anton H.J., Mitashov V.I. Adv. Space Res. 1998. V. 22. N.2. P. 293-301. [2] Grigoryan E

  4. Meso-Scale Modelling of Deformation, Damage and Failure in Dual Phase Steels

    NASA Astrophysics Data System (ADS)

    Sari Sarraf, Iman

    Advanced high strength steels (AHSS), such as dual phase (DP) and transformation induced plasticity (TRIP) steels, offer high ductility, formability, and strength, as well as high strength-to-weight ratio and improved crash resistance. Dual phase steels belong to a family of high strength grades which consist of martensite, responsible for strengthening, distributed in a ductile ferrite matrix which accommodates the deformation throughout the forming process. It has been shown that the predominant damage mechanism and failure in DP steels depends on the ferrite and martensite grain sizes and their morphology, and can range from a mixture of brittle and ductile rupture to completely ductile rupture in a quasi-static uniaxial tension test. In this study, a hybrid finite element cellular automata model, initially proposed by Anton Shterenlikht (2003), was developed to evaluate the forming behaviour and predict the onset of instability and damage evolution in a dual phase steel. In this model, the finite element constitutive model is used to represent macro-level strain gradients and a damage variable, and two different cell arrays are designed to represent the ductile and brittle fracture modes in meso-scale. In the FE part of the model, a modified Rousselier ductile damage model is developed to account for nucleation, growth and coalescence of voids. Also, several rate-dependent hardening models were developed and evaluated to describe the work hardening flow curve of DP600. Based on statistical analysis and simulation results, a modified Johnson-Cook (JC) model and a multiplicative combination of the Voce-modified JC functions were found to be the most accurate hardening models. The developed models were then implemented in a user-defined material subroutine (VUMAT) for ABAQUS/Explicit finite element simulation software to simulate uniaxial tension tests at strain rates ranging from 0.001 1/s to 1000 1/s, Marciniak tests, and electrohydraulic free-forming (EHFF

  5. Crustal Structure in the Southern Rockall Trough from Satellite Gravity Data: Evidence for Sea-floor Spreading

    NASA Astrophysics Data System (ADS)

    Chappell, A.; Kusznir, N. J.

    2005-05-01

    The southern Rockall Trough south of 57 N has previously been interpreted as either an intra-continental rift floored with highly extended continental crust, or a failed oceanic rift formed by Cretaceous sea floor spreading. Satellite gravity, bathymetry data and seismic estimates of sediment thickness are used to derive crustal basement thickness for the southern Rockall Trough and adjacent regions using a gravity inversion method incorporating a correction for the large negative thermal gravity component present in oceanic and stretched continental lithosphere. The marine Bouguer anomaly, derived from satellite free air gravity (Sandwell & Smith 1997) and Gebco 2003 bathymetry data, is inverted using the method of Oldenberg (1974), incorporating an iteratively applied thermal anomaly correction, to give Moho depth. For oceanic crust the thermal anomaly correction is calculated using isochron ages (Muller et al. 1997) and for continental crust from the beta stretching factors resulting from gravity derived crustal basement thickness and an assumed rift age. When sediment thickness and volcanic addition are assumed to be zero, the resulting upper bound of crustal thickness from the gravity inversion is as little as 10 km in the southern Rockall Trough. A segmented axial thickening of the crust at the centre of the Rockall Trough is predicted, between the Barra volcanic ridge and the Anton Dohrn seamount and is interpreted as having a volcanic origin. Inclusion of a sediment thickness correction in the gravity inversion further reduces predicted crustal thickness. A pseudo-sediment-thickness map has been constructed from the available wide-angle data and incorporated in the gravity inversion. The addition of up to 5.5 km of sediment in the gravity inversion reduces the upper bound of crustal thickness to less than 3 km in some locations. The segmented axial thickening and thin crust shown by the gravity inversion, the lack of intra-basinal faulting, and the volcanic

  6. Optical and Acoustical Techniques for Non-viral Gene Delivery to Mammalian Cells and In-situ Study of Cytoskeletal Mechanics

    NASA Astrophysics Data System (ADS)

    Ma, Zili

    Since the first optical microscope invented by Anton van Leeuwenhoek in 1674, the great development of laser technique and its applications in biophotonics have helped us reveal the mechanisms underlying numerous biological activities gradually. The introduction of fs lasers to the studies of biology has emerged as a fast developing area calling for the efforts and skills both from optics and electric engineering and biology and medicine. Due to the fast update of laser source techniques, there has been an increasing number of commercialized fs lasers available for this growing market of biophotonics. To better utilize the potential offered by fs lasers, we studied the technique of optical gene delivery and tried to narrow the gap between laboratorial research and industrial/clinical applications, in that the strict experimental conditions of specific optical laboratorial studies are generally not appropriate for the practical biological applications. To carry out our experiments, we built a two-stage amplifier fs laser system to generate the desired pulse train. The laser pulse train was coupled into an invert fluorescence microscope for the imaging and manipulation of each cell. To overcome limitations brought by the tight focus of laser beam due to high NA objective, we introduced gold nanorods (GNRs), a metallic nanomaterial, with tunable optical property. With these additional membrane for membrane permeabilization, which could significantly improve the manipulation speed than that based on the tightly focused laser. We used GFP plasmid to demonstrate the applications of this technique in gene delivery, and successfully transfected and GFP-expressed cells were observed one day after the optical transfection. Additionally, as an important trend of biophotonics, the integration of optics with microfluidic chips has become the new frontier of both biology and engineering. Here we firstly demonstrated a technique of gene delivery by an on-chip device generating

  7. The "DREAM" IODP project to drill the Mediterranean Salt Giant on the Balearic Promontory

    NASA Astrophysics Data System (ADS)

    Lofi, Johanna; Camerlenghi, Angelo; Aloisi, Giovanni; Maillard, Agnès; Garcia-Castellanos, Daniel; Huebscher, Christian; Kuroda, Junichiro

    2017-04-01

    should allow testing 1) the contradictory emplacement models that explain its genesis and 2) the presence of halophilic micro-organisms it may host/feed. DREAM is a part of a bigger Multi-phase IODP Drilling Project entitled "Uncovering a Salt Giant" (857-MDP, coord. A. Camerlenghi) born out of a series of workshops and international initiatives carried out since 2014. The DREAM pre-proposal P857B has been accepted by the IODP Science Evaluation Panel in January 2016. The full-proposal will be submitted after the acquisition of complementary Site Survey Data in 2017. The DREAM project is performed in close link with various international initiatives including the COST Action CA15103 and ANR Project MEDSALT (Camerlenghi et al., this congress) and the IMMAGE ICDP-IODP amphibious proposal (Flecker et al., this congress). DREAM co-proponents: J. Anton, M.A. Bassetti, D. Birgel, R. Bourillot, A. Caruso, H. Daigle, G. DeLange, F. Dela Pierre, R. Flecker, V. Gaullier, D. Hodell, F. Jimenez-Espejo, W. Krijgsman, L. Lourens, S. Lugli, V. Manzi, T. McGenity, J. McKenzie, P. Meijer, H. Moreno, A. Moscariello, P. Munch, N. Ohkouchi, J. Peckmann, P. Pezard, J. Poort, M. Roveri, F. Sierro, K. Takai, T. Treude.

  8. Platelet Rich Plasma and Hyaluronic Acid Blend for the Treatment of Osteoarthritis: Rheological and Biological Evaluation

    PubMed Central

    Russo, Fabrizio; D’Este, Matteo; Vadalà, Gianluca; Cattani, Caterina; Papalia, Rocco; Alini, Mauro; Denaro, Vincenzo

    2016-01-01

    Introduction Osteoarthritis (OA) is the most common musculoskeletal disease. Current treatments for OA are mainly symptomatic and inadequate since none results in restoration of fully functional cartilage. Hyaluronic Acid (HA) intra-articular injections are widely accepted for the treatment of pain associated to OA. The goal of HA viscosupplementation is to reduce pain and improve viscoelasticity of synovial fluid. Platelet-rich plasma (PRP) has been also employed to treat OA to possibly induce cartilage regeneration. The combination of HA and PRP could supply many advantages for tissue repair. Indeed, it conjugates HA viscosupplementation with PRP regenerative properties. The aim of this study was to evaluate the rheological and biological properties of different HA compositions in combination with PRP in order to identify (i) the viscoelastic features of the HA-PRP blends, (ii) their biological effect on osteoarthritic chondrocytes and (iii) HA formulations suitable for use in combination with PRP. Materials and Methods HA/PRP blends have been obtained mixing human PRP and three different HA at different concentrations: 1) Sinovial, 0.8% (SN); 2) Sinovial Forte 1.6% (SF); 3) Sinovial HL 3.2% (HL); 4) Hyalubrix 1.5% (HX). Combinations of phosphate buffered saline (PBS) and the four HA types were used as control. Rheological measurements were performed on an Anton PaarMCR-302 rheometer. Amplitude sweep, frequency sweep and rotational measurements were performed and viscoelastic properties were evaluated. The rheological data were validated performing the tests in presence of Bovine Serum Albumin (BSA) up to ultra-physiological concentration (7%). Primary osteoarthritic chondrocytes were cultured in vitro with the HA and PRP blends in the culture medium for one week. Cell viability, proliferation and glycosaminoglycan (GAG) content were assessed. Results PRP addition to HA leads to a decrease of viscoelastic shear moduli and increase of the crossover point, due to a

  9. Visions of Discovery

    NASA Astrophysics Data System (ADS)

    Chiao, Raymond Y.; Cohen, Marvin L.; Leggett, Anthony J.; Phillips, William D.; Harper, Charles L., Jr.

    2010-10-01

    physics? Steven Chu; 20. Quantum information J. Ignacio Cirac; 21. Emergence in condensed matter physics Marvin L. Cohen; 22. Achieving the highest spectral resolution over the widest spectral bandwidth: precision measurement meets ultrafast science Jun Ye; 23. Wireless non-radiative energy transfer Marin Soljačić; Part V. Consciousness and Free Will: 24. The big picture: exploring questions on the boundaries of science - consciousness and free will George F. R. Ellis; 25. Quantum entanglement: from fundamental questions to quantum communication and quantum computation and back Anton Zeilinger; 26. Consciousness, body, and brain: the matter of the mind Gerald M. Edelman; 27. The relation between quantum mechanics and higher brain functions: lessons from quantum computation and neurobiology Christof Koch and Klaus Hepp; 28. Free will and the causal closure of physics Robert C. Bishop; 29. Natural laws and the closure of physics Nancy L. Cartwright; 30. Anti-Cartesianism and downward causation: reshaping the free-will debate Nancey Murphy; 31. Can we understand free will? Charles H. Townes; Part VI. Reflections on the Big Questions: Mind, Matter. Mathematics, and Ultimate Reality: 32. The big picture: exploring questions on the boundaries of science - mind, matter, mathematics George F. R. Ellis; 33. The mathematical universe Max Tegmark; 34. Where do the laws of physics come from? Paul C. W. Davies; 35. Science, energy, ethics, and civilization Vaclav Smil; 36. Life of science, life of faith William T. Newsome; 37. The science of light and the light of science: an appreciative theological reflection on the life and work of Charles Hard Townes Robert J. Russell; 38. Two quibbles about 'ultimate' Gerald Gabrielse; Index.

  10. Adherence to Web-Based Self-Assessments in Long-Term Direct-to-Patient Research: Two-Year Study of Multiple Sclerosis Patients.

    PubMed

    Jongen, Peter Joseph; Kremer, Ingrid E H; Hristodorova, Elena; Evers, Silvia M A A; Kool, Anton; van Noort, Esther M; Hiligsmann, Mickaël

    2017-07-21

    completion adherent for the MSQoL-54 and MA questionnaires, respectively. Whereas 85.5% (142/166) of the patients were interval adherent for the MSIP and MSQoL-54, 25.5% (41/161) were interval adherent for the MA questionnaire, with 73.9% (119/161) exceeding the maximum MA monthly interassessment interval. Completion adherence for the monthly short MA questionnaire was higher in patients with moderately high disability (EDSS 5.0-5.5) than for those with no or minimal disability (EDSS 0-2.5) (OR 5.47, 95% CI 1.08-27.69; P=.040). Completion adherence was also higher in patients with EDSS assessment within 6 months after baseline than in those with later assessment (OR 1.810, 95% CI 0.999-3.280; P=.050). The 2-year completion adherence to Web-based self-assessments did not differ between the low-frequency long questionnaires and a high-frequency short questionnaire, but the interval adherence was substantially higher for the low-frequency long questionnaires. Personal contact with a member of the research team regarding a clinically relevant professional-reported outcome early in the study might positively affect the long-term completion adherence in direct-to-patient studies. ©Peter Joseph Jongen, Ingrid E.H. Kremer, Elena Hristodorova, Silvia M.A.A. Evers, Anton Kool, Esther M van Noort, Mickaël Hiligsmann. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 21.07.2017.

  11. FOREWORD: The XXV IAHR Symposium on Hydraulic Machinery and Systems marks half a century tradition

    NASA Astrophysics Data System (ADS)

    Susan-Resiga, Romeo

    2010-05-01

    'Politehnica' of Timisoara in 1923 'It is not the walls that make a school, but the spirit living inside'. A particular trademark of the 'Politehnica' of Timisoara was the continuous effort to answer industrial problems by training the students not only on theoretical aspects but also in design and manufacturing, as well as in laboratory works. Developing modern laboratories, where students can observe and understand first hand the engineering applications along the years a priority for Timisoara 'Politehnica' University. The School of Hydraulic Machinery within the 'Politehnica' University of Timisoara was established in early 1930 by Professor Aurel Barglazan (1905-1960), and further developed by Professor Ioan Anton (born 1924), both members of the Romanian Academy. The Laboratory of Hydraulic Machines from Timisoara (LMHT) started back in 1928 in a small hut, with a test rig for Francis and Kaplan turbines manufactured by J M Voith. LMHT was continuously developed and was officially recognized in 1959 as being one of the leading research and developing laboratories in Romania. It was the foundation of the Romanian efforts of designing and manufacturing hydraulic turbines starting in 1960 at the Resita Machine Building Factory. Under the leadership of Professor Ioan Anton, the Timisoara School in Hydraulic Machinery has focused the basic and development research activities on the following main topics: (i) Turbine Hydrodynamics, (ii) Hydrofoil Cascade Hydrodynamics, (iii) Cavitation in Hydraulic Machines and Equipments, (iv) Scale-up Effects in Hydraulic Machines. With the establishment in the year 2000 of the National Center for Engineering of Systems with Complex Fluids, within the 'Politehnica' University of Timisoara, the research in turbomachinery hydrodynamics and cavitation included high performance computing for flows in hydraulic machines, as well as the development of novel technologies to mitigate the self-induced flow instabilities in hydraulic turbines operated

  12. EDITORIAL: Focus on Quantum Cryptography: Theory and Practice FOCUS ON QUANTUM CRYPTOGRAPHY: THEORY AND PRACTICE

    NASA Astrophysics Data System (ADS)

    Lütkenhaus, N.; Shields, A. J.

    2009-04-01

    descriptions and are based on observable tests during the run of QKD sessions. It is now 25 years since the first proposal for QKD was published and 20 since the first experimental realization. The intervening years have brought several technological and theoretical advances, which have driven new insights into the application of quantum theory to the wider field of information technology. We are looking forward to the new twists and turns this field will take in the next 25 years! Focus on Quantum Cryptography: Theory and Practice Contents Security of continuous-variable quantum key distribution: towards a de Finetti theorem for rotation symmetry in phase space A Leverrier, E Karpov, P Grangier and N J Cerf Optical networking for quantum key distribution and quantum communications T E Chapuran, P Toliver, N A Peters, J Jackel, M S Goodman, R J Runser, S R McNown, N Dallmann, R J Hughes, K P McCabe, J E Nordholt, C G Peterson, K T Tyagi, L Mercer and H Dardy Proof-of-concept of real-world quantum key distribution with quantum frames I Lucio-Martinez, P Chan, X Mo, S Hosier and W Tittel Composability in quantum cryptography Jörn Müller-Quade and Renato Renner Distributed authentication for randomly compromised networks Travis R Beals, Kevin P Hynes and Barry C Sanders Feasibility of 300 km quantum key distribution with entangled states Thomas Scheidl, Rupert Ursin, Alessandro Fedrizzi, Sven Ramelow, Xiao-Song Ma, Thomas Herbst, Robert Prevedel, Lothar Ratschbacher, Johannes Kofler, Thomas Jennewein and Anton Zeilinger Decoy-state quantum key distribution with both source errors and statistical fluctuations Xiang-Bin Wang, Lin Yang, Cheng-Zhi Peng and Jian-Wei Pan High rate, long-distance quantum key distribution over 250 km of ultra low loss fibres D Stucki, N Walenta, F Vannel, R T Thew, N Gisin, H Zbinden, S Gray, C R Towery and S Ten Topological optimization of quantum key distribution networks R Alléaume, F Roueff, E Diamanti and N Lütkenhaus The SECOQC quantum key

  13. The Secret Lives Of Galaxies Unveiled In Deep Survey

    NASA Astrophysics Data System (ADS)

    2003-06-01

    South This increase in galaxy size is consistent with "bottom-up" models, where galaxies grow hierarchically, through mergers and accretion of smaller satellite galaxies. This is also consistent with the idea the sizes of galaxies match hand-in-glove to a certain fraction of the sizes of their dark-matter halos. Dark matter is an invisible form of mass that comprises most of the matter in the universe. The theory is dark matter essentially pooled into gravitational "puddles" in the early universe, then collected normal gas that quickly contracted to build star clusters and small galaxies. These dwarf galaxies merged piece-by-piece over billions of years to build the immense spiral and elliptical galaxies we see today. The Chandra observations amounted to a "high-energy core sample" of the early universe, allowing us to "study the history of black holes over almost the entire age of the universe," said Niel Brandt of Penn State University, a co-investigator on the Chandra GOODS team. One of the fascinating findings in this deepest X-ray image ever taken is the discovery of mysterious black holes, which have no optical counterparts. "We found seven mysterious sources that are completely invisible in the optical with Hubble," said Anton Koekemoer of the STScI, a co-investigator on both the Hubble and Chandra GOODS teams. "Either they are the most distant black holes ever detected, or they are less distant black holes that are the most dust enshrouded known, a surprising result as well." When comparing the HST and Chandra fields, astronomers also found active black holes in distant, relatively small galaxies were rarer than expected. This may be due to the effects of early generations of massive stars that exploded as supernovae, evacuating galactic gas and thus reducing the supply of gas needed to feed a super massive black hole. These and other results from the GOODS project will be published in a special issue of the Astrophysical Journal Letters, entirely devoted to the

  14. PREFACE: International Conference on Topics in Astroparticle and Underground Physics (TAUP 2011)

    NASA Astrophysics Data System (ADS)

    Oberauer, Lothar; Raffelt, Georg; Wagner, Robert

    2012-07-01

    The 12th edition of the International Conference on Topics in Astroparticle and Underground Physics (TAUP 2011) was held 5-9 September 2011 in Munich (and for the first time in Germany). It was organized by the Max Planck Institute for Physics (MPP), the Technical University Munich (TUM) and the Cluster of Excellence 'Origin and Structure of the Universe'. The conference was held in the 'Künstlerhaus', a traditional downtown location for artistic festivities. The meeting attracted 317 participants (61 of which were women) from 29 countries, see figure below. The topics covered by the meeting were Cosmology and particle physics, Dark matter and its detection, Neutrino physics and astrophysics, Gravitational waves and High-energy astrophysics and cosmic rays, and the various interfaces between these areas. The scientific sessions consisted of five mornings of plenary talks, four afternoons of parallel sessions, and an evening poster session. The co-founder of the conference series, Alessandro Bottino, has decided to retire from the position of chairman of the TAUP Steering Committee after the completion of TAUP 2011. On behalf of all followers of this series, we thank him for having started these inspiring events and his many years of dedicated service. We thank all speakers, conveners and participants as well as the members of the organizing, steering and international advisory committee for making this a successful and memorable meeting. Lothar Oberauer, Georg Raffelt, Robert Wagner Proceedings editors Figure Committees International Advisory Committee G AntonUniversity of Erlangen E AprileColumbia University M Baldo-CeolinUniversity of Padova R BattistonUniversity of Perugia & INFN L BergströmUniversity Stockholm R BernabeiUniversity of Rome 'Tor Vergata' A BettiniLSC Canfranc P BinetruyAPC Paris J BlümerKarlsruhe Institute of Technology B CabreraStanford University A CaldwellMax Planck Institute for Physics M ChenQueens University E CocciaUniversity of Rome

  15. REPORT OF RESEARCH ACCOMPLISHMENTS AND FUTURE GOALS HIGH ENERGY PHYSICS

    SciT

    Wise, Mark B.; Kapustin, Anton N.; Schwarz, John Henry

    . Areas of activity include: CDMS II data analysis, contributions to SuperCDMS Soudan operations and analysis, R&D towards SuperCDMS SNOLAB, development of a novel screener for radiocontamination (the BetaCage), and development of new WIMP detector concepts. Ren-Yuan Zhu leads the HEP crystal laboratory for the advanced detector R&D effort. The crystal lab is involved in development of novel scintillating crystals and has proposed several crystal based detector concepts for future HEP experiments at the energy and intensity frontiers. Its current research effort is concentrated on development of fast crystal scintillators with good radiation hardness and low cost. II) THEORETICAL PHYSICS The main theme of Sergei Gukov's current research is the relation between the geometry of quantum group invariants and their categorification, on the one hand, and the physics of supersymmetric gauge theory and string theory, on the other. Anton Kapustin's research spans a variety of topics in non-perturbative Quantum Field Theory (QFT). His main areas of interest are supersymmetric gauge theories, non-perturbative dualities in QFT, disorder operators, Topological Quantum Field Theory, and non-relativistic QFT. He is also interested in the foundations and possible generalizations of Quantum Mechanics. Hirosi Ooguri's current research has two main components. One is to find exact results in Calabi-Yau compactification of string theory. Another is to explore applications of the AdS/CFT correspondence. He also plans to continue his project with Caltech postdoctoral fellows on BPS spectra of supersymmetric gauge theories in diverse dimensions. John Preskill works on quantum information science. This field may lead to important future technologies, and also lead to new understanding of issues in fundamental physics John Schwarz has been exploring a number of topics in superstring theory/M-theory, supersymmetric gauge theory, and their AdS/CFT relationships. Much of the motivation for these

  16. EDITORIAL: Fluctuations and noise in photonics and quantum optics: a special issue in memory of Hermann Haus

    NASA Astrophysics Data System (ADS)

    Abbott, Derek; Shapiro, Jeffrey H.; Yamamoto, Yoshihisa

    2004-08-01

    , USA Peter R Smith Loughborough University of Technology, UK Rodney S Tucker University of Melbourne, Australia Howard M Wiseman Griffith University, Brisbane, Australia Stuart A Wolf DARPA, Arlington, VA, USA Anton Zeilinger University of Vienna, Austria Xi-Cheng Zhang Rensselaer Polytechnic Institute, Troy, NY, USA

  17. Sensitivity of ocean model simulation in the coastal ocean to the resolution of the meteorological forcing

    NASA Astrophysics Data System (ADS)

    Chen, Feng; Shapiro, Georgy; Thain, Richard

    2013-04-01

    Zatsepin , Valentina Khan, Valery Prostakishin , Tatiana Akivis , Vladimir Belokopytov , Anton Sviridov , and Vladimir Piotukh . 2011. Response of water temperature in the Black Sea to atmospheric forcing: the sensitivity study. Geophysical Research Abstracts. Vol. 13, EGU2011-933

  18. International Agreement Will Advance Radio Astronomy

    NASA Astrophysics Data System (ADS)

    2007-12-01

    Two of the world's leading astronomical institutions have formalized an agreement to cooperate on joint efforts for the technical and scientific advancement of radio astronomy. The National Radio Astronomy Observatory (NRAO) in the United States and the Max-Planck Institute for Radioastronomy (MPIfR) in Germany concluded a Memorandum of Understanding outlining planned collaborative efforts to enhance the capabilities of each other's telescopes and to expand their cooperation in scientific research. The VLBA The VLBA CREDIT: NRAO/AUI/NSF In the first project pursued under this agreement, the MPIfR will contribute $299,000 to upgrade the continent-wide Very Long Baseline Array's (VLBA) capability to receive radio emissions at a frequency of 22 GHz. This improvement will enhance the VLBA's scientific productivity and will be particularly important for cutting-edge research in cosmology and enigmatic cosmic objects such as gamma-ray blazars. "This agreement follows many years of cooperation between our institutions and recognizes the importance of international collaboration for the future of astronomical research," said Fred K.Y. Lo, NRAO Director. "Our two institutions have many common research goals, and joining forces to keep all our telescopes at the forefront of technology will be highly beneficial for the science," said Anton Zensus, Director at MPIfR. In addition to the VLBA, the NRAO operates the Very Large Array (VLA) in New Mexico and the Robert C. Byrd Green Bank Telescope (GBT) in West Virginia. The MPIfR operates the 100-meter Effelsberg Radio Telescope in Germany and the 12-meter APEX submillimeter telescope in 5100 m altitude in the Cilean Atacama desert (together with the European Southern Observatory and the Swedish Onsala Space Observatory). With the 100-meter telescope, it is part of the VLBA network in providing transatlantic baselines. Both institutions are members of a global network of telescopes (the Global VLBI Network) that uses simultaneous

  19. PREFACE: EmQM13: Emergent Quantum Mechanics 2013

    NASA Astrophysics Data System (ADS)

    2014-04-01

    these proceedings represent the talks of the invited speakers as written immediately after the symposium. The volume starts with a contribution by organizers Jan Walleczek and Gerhard Grössing, essentially explaining why emergent quantum mechanics, and other deterministic approaches to quantum theory, must be considered viable approaches in quantum foundations today. This is followed by the exposition of Stephen Adler's talk who introduced to a general audience key questions at the current frontiers of quantum mechanics during the opening evening (with the contents of his conference talk appearing elsewhere). The conference proceedings then continues with the presentations as given in their chronological order i.e. starting with the opening talk of the scientific program by Gerard 't Hooft. While the page number was restricted for all invited speakers, the paper by Jeff Tollaksen was given more space, as his invited collaborator Yakir Aharonov was unable to deliver a separate talk, in order to represent both contributions in one paper. Note that the talks of all speakers, including the talks of those who could not be represented in this volume (M. Arndt, B. Braverman, C. Brukner, S. Colin, Y. Couder, B. Poirier, A. Steinberg, G. Weihs and H. Wiseman) are freely available on the conference website as video presentations (http://www.emqm13.org). The organizers wish to express their gratitude to Siegfried Fussy and Herbert Schwabl from AINS for the organizational support. The organizers also wish to thank Bruce Fetzer, President and CEO, John E. Fetzer Memorial Trust, and the Members of the Board of Trustees, for their strong support and for funding this symposium. We also wish to thank the Austrian Academy of Sciences for allowing the symposium to be held on their premises, and Anton Zeilinger, President of the Austrian Academy of Sciences, for his welcome address. The expertise of the Members of the Scientific Advisory Board of the EmQM13 symposium, Ana Maria Cetto

  20. Computational study of pristine and titanium-doped sodium alanates for hydrogen storage applications

    NASA Astrophysics Data System (ADS)

    Dathar, Gopi Krishna Phani

    The emphasis of this research is to study and elucidate the underlying mechanisms of reversible hydrogen storage in pristine and Ti-doped sodium aluminum hydrides using molecular modeling techniques. An early breakthrough in using complex metal hydrides as hydrogen storage materials is from the research on sodium alanates by Bogdanovic et al., in 1997 reporting reversible hydrogen storage is possible at moderate temperatures and pressures in transition metal doped sodium alanates. Anton reported titanium salts as the best catalysts compared to all other transition metal salts from his further research on transition metal doped sodium alanates. However, a few questions remained unanswered regarding the role of Ti in reversible hydrogen storage of sodium alanates with improved thermodynamics and kinetics of hydrogen desorption. The first question is about the position of transition metal dopants in the sodium aluminum hydride lattice. The position is investigated by identifying the possible sites for titanium dopants in NaAlH4 lattice and studying the structure and dynamics of possible compounds resulting from titanium doping in sodium alanates. The second question is the role of titanium dopants in improved thermodynamics of hydrogen desorption in Ti-doped NaAlH4. Though it is accepted in the literature that formation of TiAl alloys (Ti-Al and TiAl3) is favorable, reaction pathways are not clearly established. Furthermore, the source of aluminum for Ti-Al alloy formation is not clearly understood. The third question in this area is the role of titanium dopants in improved kinetics of hydrogen absorption and desorption in Ti-doped sodium alanates. This study is directed towards addressing the three longstanding questions in this area. Thermodynamic and kinetic pathways for hydrogen desorption in pristine NaAlH4 and formation of Ti-Al alloys in Ti-doped NaAlH 4, are elucidated to understand the underlying mechanisms of hydrogen desorption. Density functional theory

  1. PREFACE: EmerQuM 11: Emergent Quantum Mechanics 2011 (Heinz von Foerster Congress)

    NASA Astrophysics Data System (ADS)

    Grössing, Gerhard

    2012-05-01

    These proceedings comprise the plenary lectures and poster contributions of the 'Heinz von Foerster Conference 2011' on Emergent Quantum Mechanics (EmerQuM11), which was held at the University of Vienna, 11-13 November 2011. With the 5th International Heinz von Foerster Conference convened at the occasion of von Foerster's 100th birthday, the organizers opted for a twin conference to take place at the Large and Small Ceremonial Halls of the University's main building, respectively. The overall topic was chosen as 'Self-Organization and Emergence', a topic to which von Foerster was an early contributor. While the first conference ('Self-Organization and Emergence in Nature and Society') addressed a more general audience, the second one ('Emergent Quantum Mechanics') was intended as a specialist meeting with a contemporary topic that could both serve as an illustration of von Foerster's intellectual heritage and, more generally, point towards future directions in physics. We thus intended to bring together many of those physicists who are interested in or are working on attempts to understand quantum mechanics as emerging from a suitable classical (or, more generally, deeper level) physics. EmerQuM11 was organized by the Austrian Institute for Nonlinear Studies (AINS), with essential support from the Wiener Institute for Social Science Documentation and Methodology (WISDOM), the Department of Contemporary History at the University of Vienna, and the Heinz von Foerster-Gesellschaft. There were a number of individuals who contributed to the smooth course of our meeting and whom I would like to sincerely thank: Christian Bischof, Thomas Elze, Marianne Ertl, Gertrud Hafner, Werner Korn, Angelika Krawanja, Florian Krug and his team, Sonja Lang, Albert Müller, Ilse Müller, Irene Müller, Karl Müller, Armin Reautschnig, Marion Schirrmacher, Anton Staudinger, Roman Zlabinger, and, last but not least, my AINS colleagues Siegfried Fussy, Herbert Schwabl and Johannes Mesa

  2. Committees

    NASA Astrophysics Data System (ADS)

    2012-11-01

    Leadership Team of the IAHR Committee for Hydraulic Machinery and Systems Eduard EGUSQUIZA, UPC Barcelona, Spain, Chair François AVELLAN, EPFL-LMH, Switzerland, Past Chair Richard K FISHER, Voith Hydro Inc., USA, Past Chair Fidel ARZOLA, Edelca, Venezuela Michel COUSTON, Alstom Hydro, France Niklas DAHLBÄCKCK, Vatenfall, Sweden Normand DESY, Andritz VA TECH Hydro Ltd., Canada Chisachi KATO, University of Tokyo, Japan Andrei LIPEJ, Turboinstitut, Slovenija Torbjørn NIELSEN, NTNU, Norway Romeo SUSAN-RESIGA, 'Politehnica' University Timisoara, Romania Stefan RIEDELBAUCH, Stuggart University, Germany Albert RUPRECHT, Stuttgart University, Germany Qing-Hua SHI, Dong Fang Electrical Machinery Co., China Geraldo TIAGO, Universidade Federal de Itajubá, Brazil International Advisory Committee Shouqi YUAN (principal) Jiangsu University China QingHua SHI (principal) Dong Fang Electrical Machinery Co. China Fidel ARZOLA EDELCA Venezuela Thomas ASCHENBRENNER Voith Hydro GmbH & Co. KG Germany Anton BERGANT Litostroj Power doo Slovenia B C BHAOYAL Research & Technology Centre India Hermod BREKKE NTNU Norway Stuart COULSON Voith Hydro Inc. USA Paul COOPER Fluid Machinery Research Inc USA V A DEMIANOV Power Machines OJSC Russia Bart van ESCH Technische Universiteit Eindhoven Netherland Arno GEHRER Andritz Hydro Graz Austria Akira GOTO Ebara Corporation Japan Adiel GUINZBURG The Boeing Company USA D-H HELLMANN KSB AG Germany Ashvin HOSANGADI Combustion Research and Flow Technology USA Byung-Sun HWANG Korea Institute of Material Science Korea Toshiaki KANEMOTO Kyushu Institute of Technology Japan Mann-Eung KIM Korean Register of Shipping Korea Jiri KOUTNIK Voith Hydro GmbH & Co. KG Germany Jinkook LEE Eaton Corporation USA Young-Ho LEE Korea Maritime University Korea Woo-Seop LIM Hyosung Goodsprings Inc Korea Jun MATSUI Yokohama National University Japan Kazuyoshi Mitsubishi H I Ltd, Japan MIYAGAWA Christophe NICOLET Power Vision Engineering Srl Switzerland Maryse PAGE Hydro

  3. PREFACE: ARENA 2006—Acoustic and Radio EeV Neutrino detection Activities

    NASA Astrophysics Data System (ADS)

    Thompson, Lee

    2007-06-01

    The International Conference on Acoustic and Radio EeV Neutrino Activities, ARENA 2006 was jointly hosted by the Universities of Northumbria and Sheffield at the City of Newcastle Campus of the University of Northumbria in June 2006. ARENA 2006 was the latest in a series of meetings which have addressed, either separately or jointly, the use of radio and acoustic sensors for the detection of highly relativistic particles. Previous successful meetings have taken place in Los Angeles (RADHEP, 2000), Stanford (2003) and DESY Zeuthen (ARENA 2005). A total of 50 scientists from across Europe, the US and Japan attended the conference presenting status reports and results from a number of projects and initiatives spread as far afield as the Sweden and the South Pole. The talks presented at the meeting and the proceedings contained herein represent a `snapshot' of the status of the fields of acoustic and radio detection at the time of the conference. The three day meeting also included two invited talks by Dr Paula Chadwick and Dr Johannes Knapp who gave excellent summaries of the related astroparticle physics fields of high energy gamma ray detection and high energy cosmic ray detection respectively. As well as a full academic agenda there were social events including a Medieval themed conference banquet at Lumley Castle and a civic reception kindly provided by the Lord Mayor of Newcastle and hosted at the Mansion House. Thanks must go to the International Advisory Board members for their input and guidance, the Local Organising Committee for their hard work in bringing everything together and finally the delegates for the stimulating, enthusiastic and enjoyable spirit in which ARENA 2006 took place. Lee Thompson

    International Advisory Board

    G. Anton, ErlangenD. Besson, Kansas
    J. Blümer, KarlsruheA. Capone, Rome
    H. Falcke, BonnP. Gorham, Hawaii
    G. Gratta

  4. PREFACE: 13th International Conference on Electrorheological Fluids and Magnetorheological Suspensions (ERMR2012)

    NASA Astrophysics Data System (ADS)

    Unal, Halil Ibrahim

    2013-02-01

    F Gonzalez-Caballero in 2014. It is expected that during the next conference, the interaction between polymer chemists synthesizing the new ER/MR materials, experimentalists from the rheological side characterizing their rheological properties, theoretical physicists describing the electric field and magnetic field dependent phenomena in ER/MR fluids rheology, and mechanical engineers conducting vibration damping tests will give rise to a deeper understanding of the ER/MR phenomena and will result in new findings in this field. The conference was sponsored by Gazi University, Anton-Paar GmbH, Kurimoto Ltd., Anamed Analitik Grup, TA Instruments, LORD Corporation, Turkish Powder Metallurgy Association (TTMD), LiKrom Ltd, Atomika Ltd., Turkish Patent Institute (TPI), Berkecan Ltd., Kurukahveci Mehmed Efendi Mahdumlari and Turkish Science-Research Foundation (TUBAV). The organizing committee truly appreciates the support from these organizations. Special appreciation is also due to my students O Erol and H C Gullu. I would also like to thank members of the Local Organizing Committee and International Advisory Board. Guest Editor H Ibrahim Unal Gazi University Science Faculty Chemistry Department 06500 Ankara/Turkey E-mail: hiunal@gazi.edu.tr

  5. Observing a Burst with Sunglasses

    NASA Astrophysics Data System (ADS)

    2003-11-01

    factor by which the lines in the spectrum of an object are shifted towards longer wavelengths. Since the redshift of a cosmological object increases with distance, the observed redshift of a remote galaxy also provides an estimate of its distance. [2]: Members of the team include Jochen Greiner, Arne Rau (Max-Planck-Institut für extraterrestrische Physik, Germany), Sylvio Klose, Bringfried Stecklum (Thüringer Landessternwarte Tautenburg, Germany), Klaus Reinsch (Universitätssternwarte Göttingen, Germany), Hans Martin Schmid (Institut für Astronomie Zürich, Switzerland ), Re'em Sari (California Institute of Technology, USA), Dieter H. Hartmann (Clemson University, USA), Chryssa Kouveliotou (NSSTC, Huntsville, Alabama, USA), Eliana Palazzi (Istituto di Astrofisica Spaziale e Fisica Cosmica, Bologna, Italy), Christian Straubmeier (Physikalisches Institut Köln, Germany), Sergej Zharikov, Gaghik Tovmassian (Instituto de Astronomia Ensenada, Mexico), Otto Bärnbantner, Christop Ries (Wendelstein-Observatorium München, Germany), Emmanuel Jehin, Andreas Kaufer (European Southern Observatory, Chile), Arne Henden (USNO Flagstaff, USA), Anlaug A. Kaas (NOT, La Palma, Spain), Tommy Grav (University of Oslo, N), Jens Hjorth, Holger Pedersen (Astronomical Observatory Copenhagen, Denmark), Ralph A.M.J. Wijers (Astronomical Institute Anton Pannekoek, Amsterdam, The Netherlands), Hye-Sook Park (Lawrence Livermore Nat. Laboratory, USA), Grant Williams (MMT Observatory, Tucson, USA), Olaf Reimer (Theoretische Weltraum- und Astrophysik Universität Bochum, Germany) [3]: When electrons - which are electrically charged - move through a magnetic field, they spiral around an axis defined by the local magnetic field. Electrons of high energy spiral very rapidly, at speeds near the speed of light. Under such conditions, the electrons emit highly polarised electromagnetic radiation. The intensity of this radiation is related to the strength of the magnetic field and the number and energy

  6. A Supermassive Black Hole in a Nearby Galaxy

    NASA Astrophysics Data System (ADS)

    2001-03-01

    black hole. It is the first time infrared spectroscopy has been used to weigh a black hole. Many other galaxies have dust-enshrouded nuclei, and the excellent capabilities of ISAAC now hold a great potential to discover and weigh many more black holes. More Information The research described in this Press Release is reported in a research article ("Peering through the dust: Evidence for a supermassive Black Hole at the Nucleus of Centaurus A from VLT IR spectroscopy"), that will appear in the international research journal the Astrophysical Journal on March 10, 2001. The full article is also available on the web as astro-ph/0011059. Note [1]: The team is composed by Ethan Schreier (Principal Investigator; Space Telescope Science Institute - STScI, Baltimore, USA), Alessandro Marconi (Arcetri Observatory, Italy), Alessandro Capetti (Turin Observatory, Italy), David Axon (University of Hertfordshire, United Kingdom), Anton Koekemoer (STScI, USA) and Duccio Macchetto (ESA/STScI, USA). Technical information about the photos PR Photo 08a/01 is reproduced from three exposures, obtained during the night of January 31 - February 1, 2000. It is a composite of three exposures in B (300 sec exposure, image quality 0.60 arcsec; here rendered in blue colour), V (240 sec, 0.60 arcsec; green) and R (240 sec, 0.55 arcsec; red). The field covered corresponds to about 80 x 80 arcsec 2 (395 x 395 pix 2 , 1 pix = 0.2 arcsec). North is up and East is left. PR Photo 08b+c/01 : The original ISAAC spectra were exposed for 35 min each with an average seeing of 0.5 arcsec. Three spectrograph slits were used, but only one of these is shown here. It was centered on the nucleus of Centaurus A and oriented at 33°, measured counter-clockwise from the North direction. The spectral pixel size is 0.6 Angstrom x 0.15 arcsec (i.e., 14 km/sec x 8.3 light-year). The large and small figures cover 2300 km/s x 1665 light-years and 1150 km/s x 330 light-years, respectively.

  7. The Dark Side of Nature: the Crime was Almost Perfect

    NASA Astrophysics Data System (ADS)

    2006-12-01

    Klose (Thüringer Landessternwarte Tautenburg, Germany), Jean-Baptiste Marquette (Institut d'Astrophysique de Paris, France), Enrico Ramirez-Ruiz (Institute for Advanced Study, Princeton and Department of Astronomy and Astrophysics, University of California, Santa Cruz, USA), Paul M. Vreeswijk (ESO and Departamento de Astronomia, Universidad de Chile, Santiago, Chile), and Ralph A. M. Wijers (Astronomical Institute 'Anton Pannekoek', University of Amsterdam, The Netherlands).

  8. INTRODUCTION: Nonequilibrium Processes in Plasmas

    NASA Astrophysics Data System (ADS)

    Petrović, Zoran; Marić, Dragana; Malović, Gordana

    2009-07-01

    have the presentation of monitoring of the deposition of airborne particles by the group from Belgrade led by Mirjana Tasić, and a study of such particles by elemental analysis by van Grieken and his colleagues from Belgium. We hope that the continuation of our workshops and the publication of our books will contribute to finding a common thread that connects different topics, even different fields, that share some aspects of the phenomena associated with non-equilibrium. As Anton Chekhov once stated 'Only entropy comes easy' so any work aimed at bringing order into the field is difficult. Organization of the workshop and publication of the book are of course not as hard as the pursuit of knowledge itself but we hope that it is, to some degree, a minor contribution to the everlasting human struggle against the entropy. And while we, of course, agree with scientists that are much better than we are that thermodynamics will never be overthrown, it is only human to try to cheat it. Doing the related science is allowing us to achieve exactly that and it is a source of numerous practical applications. The editors are grateful to all the members of the Gaseous Electronics Laboratory for organization of the workshop, in particular the members of the organizing committee and the staff of the Academy of Science and Institute of Physics. Finally and above all we acknowledge great efforts of all the participants who have invested a lot of funds, their time and effort to join us, sometimes travelling from distant continents. This book exists, however, mainly thanks to the efforts of all the authors who have invested their time and experience to write the papers. We also acknowledge the contribution by Professor Rastko Ćirić whose rendering of Maxwell's demon remains as symbol of our meeting and our publications. Perhaps the most chaotic aspect of human society, as our current experience teaches us, is the flow of funds and several agencies helped us get the needed funds to

  9. Chandra and the VLT Jointly Investigate the Cosmic X-Ray Background

    NASA Astrophysics Data System (ADS)

    2001-03-01

    Hasinger , Gyula Szokoly (Astrophysical Institute Potsdam [AIP], Germany), Colin Norman , Roberto Gilli , Lisa Kewley , Wei Zheng , Andrew Zirm , JungXian Wang (Johns Hopkins University [JHU], Baltimore, USA), Ken Kellerman (National Radio Astronomy Observatory [NRAO], Charlottesville, USA), Ethan Schreier , Anton Koekemoer and Norman Grogin (Space Telescope Science Institute (STScI), Baltimore, USA). [2] In astronomy, the redshift denotes the fraction by which the lines in the spectrum of an object are shifted towards longer wavelengths. The observed redshift of a distant galaxy or quasar gives a direct estimate of the apparent recession velocity as caused by the universal expansion. Since the expansion rate increases with the distance, the velocity is itself a function (the Hubble relation) of the distance to the object. Redshifts of 1 and 3.7 correspond to when the Universe was about 43% and 12% of its present age. The distances indicated in this Press Release depend on the cosmological model chosen and are based on an age of 19,000 million years. Technical information about the photos PR Photo 09a/01 shows B-, R- and I-band images of a 20 x 20 arcsec 2 area within the CDFS, centred on the Type II Quasar CXOCDFS J033229.9 -275106 . They were obtained with the MPG/ESO 2.2-m telescope and the Wide-Field Imager (WFI) at La Silla (B-band; 8 hrs exposure time) and the 8.2-m VLT ANTU telescope with the FORS1 multi-mode instrument at Paranal (R- and I-bands; each 2 hrs exposure). The measured magnitudes are R=23.5 and I=22.7. The overlaid contours show the associated Chandra X-ray source (smoothed with a sigma = 1 arcsec gaussian profile). North is up and East is left. The spectrum shown in PR Photo 09b/01 was obtained on November 25, 2000, with VLT ANTU and FORS1 in the multislit mode (150-I grism, 1.2 arcsec slit). The exposure time was 3 hours.

  10. The Most Remote Gamma-Ray Burst

    NASA Astrophysics Data System (ADS)

    2000-10-01

    , Denmark), Johan Fynbo, Palle Møller (European Southern Observatory), Richard Marc Kippen (University of Alabama in Huntsville and NASA/Marshall Space Flight Center, USA), Bjarne Thomsen (University of Århus, Denmark), Marianne Vestergaard (Ohio State University, USA), Nicola Masetti, Eliana Palazzi (Instituto Tecnologie e Studio Radiazoni Extraterresti, Bologna, Italy) Kevin Hurley (University of California, Berkeley, USA), Thomas Cline (NASA Goddard Space Flight Center, Greenbelt, USA), Lex Kaper (Sterrenkundig Instituut ``Anton Pannekoek", the Netherlands) and Andreas O. Jaunsen (formerly University of Oslo, Norway; now ESO-Paranal). [2]: Detailed reports about the early observations of this gamma-ray burst are available at the dedicated webpage within the GRB Coordinates Network website. [3]: The photometric redshift method makes it possible to judge the distance to a remote celestial object (a galaxy, a quasar, a gamma-ray burst afterglow) from its measured colours. It is based on the proportionality between the distance and the velocity along the line of sight (Hubble's law) that reflects the expansion of the Universe. The larger the distance of an object is, the larger is its velocity and, due to the Doppler effect, the spectral shift of its emission towards longer (redder) wavelengths. Thus, the measured colour provides a rough indication of the distance. Examples of this method are shown in ESO PR 20/98 (Photos 48a/00 and 48e/00). [4]: In fact, the object was so faint that the positioning of the spectrograph slit had to be done in "blind" offset, i.e. without actually seeing the object on the slit during the observation. This very difficult observational feat was possible because of excellent preparations by the team of astronomers and the very good precision of the telescope and instrument. [5]: The " Lyman-alpha forest" refers to the crowding of absorption lines from intervening hydrogen clouds, shortward of the strong Lyman-alpha spectral line at rest