Sample records for zone vii appendix

  1. 40 CFR Appendix Vii to Part 600 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 31 2013-07-01 2013-07-01 false [Reserved] VII Appendix VII to Part 600 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES Appendix VII to Part 600 [Reserved] ...

  2. 40 CFR Appendix Vii to Part 600 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 31 2012-07-01 2012-07-01 false [Reserved] VII Appendix VII to Part 600 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES Appendix VII to Part 600 [Reserved] ...

  3. 40 CFR Appendix Vii to Part 600 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 30 2014-07-01 2014-07-01 false [Reserved] VII Appendix VII to Part 600 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES Appendix VII to Part 600 [Reserved] ...

  4. 40 CFR Appendixes I-Vii to Part 85 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 18 2011-07-01 2011-07-01 false [Reserved] I Appendixes I-VII to Part 85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM MOBILE SOURCES Appendixes I-VII to Part 85 [Reserved] ...

  5. 40 CFR Appendixes I-Vii to Part 85 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false [Reserved] I Appendixes I-VII to Part 85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM MOBILE SOURCES Appendixes I-VII to Part 85 [Reserved] ...

  6. 40 CFR Appendixes I-Vii to Part 85 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 19 2012-07-01 2012-07-01 false [Reserved] I Appendixes I-VII to Part 85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM MOBILE SOURCES Appendixes I-VII to Part 85 [Reserved] ...

  7. 40 CFR Appendixes I-Vii to Part 85 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 19 2013-07-01 2013-07-01 false [Reserved] I Appendixes I-VII to Part 85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM MOBILE SOURCES Appendixes I-VII to Part 85 [Reserved] ...

  8. 40 CFR Appendixes I-Vii to Part 85 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 19 2014-07-01 2014-07-01 false [Reserved] I Appendixes I-VII to Part 85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM MOBILE SOURCES Appendixes I-VII to Part 85 [Reserved] ...

  9. 40 CFR Appendixes Vi-Vii to Part 600 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false [Reserved] VI Appendixes VI-VII to Part 600 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Appendixes VI-VII to Part 600 [Reserved] ...

  10. 40 CFR Appendixes Vi-Vii to Part 600 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 30 2011-07-01 2011-07-01 false [Reserved] VI Appendixes VI-VII to Part 600 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Appendixes VI-VII to Part 600 [Reserved] ...

  11. 40 CFR Appendix Vii to Part 86 - Standard Bench Cycle (SBC)

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... VII Appendix VII to Part 86—Standard Bench Cycle (SBC) 1. The standard bench aging durability procedures [Ref. § 86.1823-08(d)] consist of aging a catalyst-oxygen-sensor system on an aging bench which follows the standard bench cycle (SBC) described in this appendix. 2. The SBC requires use of an aging...

  12. 40 CFR Appendix Vii to Part 86 - Standard Bench Cycle (SBC)

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... VII Appendix VII to Part 86—Standard Bench Cycle (SBC) 1. The standard bench aging durability procedures [Ref. § 86.1823-08(d)] consist of aging a catalyst-oxygen-sensor system on an aging bench which follows the standard bench cycle (SBC) described in this appendix. 2. The SBC requires use of an aging...

  13. 20 CFR Appendix Vii to Subpart C... - “Old-Law” Contribution and Benefit Base

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false âOld-Lawâ Contribution and Benefit Base VII... Appendix VII to Subpart C of Part 404—“Old-Law” Contribution and Benefit Base Explanation: We use these... appendix IV). This is the contribution and benefit base that would have been effective under the Social...

  14. 20 CFR Appendix Vii to Subpart C... - “Old-Law” Contribution and Benefit Base

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Appendix VII to Subpart C of Part 404 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Computing Primary Insurance Amounts Pt. 404, Subpt. C, App. VII... Security Act without the enactment of the 1977 amendments. Year Amount 1979 $18,900 1980 20,400 1981 22,200...

  15. Light Helicopter Family Trade-Off Analysis. Volume 4. Appendix N

    DTIC Science & Technology

    1985-05-15

    Figur«! N -V1I-9 through N -VII-U ahow th« futl flow CMp«rlsoas chac comt|>oad r.o th« powar r«qutr«««nt* thown by flguraa (J-VII-l through M-VII-4...HELICOPTER. FAMILY TRADE-OFF ANALYSIS APPENDIX N VOLUME IV ACN: 69396 • Copy l_Q] of 130 c:optea. 15 Nay 198S ~ .. 8 06 .0&1 OTIC ELECTE AU613...TITLE (- ..... do) I. TYPf ’!! ~POitT a PI!I’IOD COVI:IU!O LIGHT HELICOPTER FAMILY TRADE-OFF ANALYSIS, Fina t y Report, APPENDIX N , VOLUME IV of XI

  16. Multiple-Purpose Project, Osage River Basin, Osage River, Missouri. Harry S. Truman Dam & Reservoir Operation and Maintenance Manual. Appendix VII. Volume 1. Construction Foundation Report.

    DTIC Science & Technology

    1984-01-01

    RIVER MISSOURI Report from September 1966 HARRY S. TROMAN DAM & RESERVOIR November 1979 OPERATION AND MAINTENANCE MANUAL 6 PERFORMING DRG. REPORT N4040E...Two of this report ) VII- I- xxiv ............................. .... ... .... ... . .2. . . OPERATION AND MAINTENANCE MANUAL HARRY S. TRUMAN DAM AND...RESERVOIR OSAGE RIVER, MISSOURI APPENDIX VII CONSTRUCTION FOUNDATION REPORT CHAPTER 1 INTRODUCTION 1-01. Location and Description of Project: Harry S

  17. 40 CFR Appendix Vii to Part 86 - Standard Bench Cycle (SBC)

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... VII to Part 86—Standard Bench Cycle (SBC) 1. The standard bench aging durability procedures [Ref. § 86.1823-08(d)] consist of aging a catalyst-oxygen-sensor system on an aging bench which follows the standard bench cycle (SBC) described in this appendix. 2. The SBC requires use of an aging bench with an...

  18. 14 CFR Appendix A to Part 141 - Recreational Pilot Certification Course

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... navigation using pilotage with the aid of a magnetic compass; (e) Recognition of critical weather situations...) Ground reference maneuvers; (vii) Navigation; (viii) Slow flight and stalls; (ix) Emergency operations..., and go-arounds; (vi) Performance maneuvers; (vii) Navigation; (viii) Emergency operations; and (ix...

  19. A Strategy for DoD Manufacturing Science and Technology R and D in Precision Fabrication

    DTIC Science & Technology

    1994-01-01

    3-11 vii Contents (Continued) Bibliography Appendix A. Progress Since the 1991 Plan Appendix B. Why "Precision" Appendix C...preci- sion fabrication R&D. Appendix A summarizes progress in precision fabrication R&D since the previous plan was prepared in 1991. Appendix B...lathe’s power consumption may indicate worn bearings. Detecting and acting on this condition can prevent costly spindle damage and associated machine down

  20. 29 CFR Appendix C to Subpart Cc of... - Operator Certification: Written Examination: Technical Knowledge Criteria

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... (iv) Boom cages. (v) Proximity to electric power lines, radii, and microwave structures. (5) The...-in-place and tilt-up. (vi) Demolition operations. (vii) Operations on water. (viii) Magnet operations... extensions. (vi) Lifting loads from beneath the surface of the water. (vii) Using various approved...

  1. 29 CFR Appendix C to Subpart Cc of... - Operator Certification: Written Examination: Technical Knowledge Criteria

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... (iv) Boom cages. (v) Proximity to electric power lines, radii, and microwave structures. (5) The...-in-place and tilt-up. (vi) Demolition operations. (vii) Operations on water. (viii) Magnet operations... extensions. (vi) Lifting loads from beneath the surface of the water. (vii) Using various approved...

  2. 44 CFR Appendix A(4) to Part 61 - Appendix A(4) to Part 61

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program INSURANCE... Insurance Administration Standard Flood Insurance Policy Endorsement to Dwelling Form This endorsement... in the inspection procedure, and become eligible for the sale of flood insurance. VII.B.4. This...

  3. 44 CFR Appendix A(4) to Part 61 - Appendix A(4) to Part 61

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program INSURANCE... Insurance Administration Standard Flood Insurance Policy Endorsement to Dwelling Form This endorsement... in the inspection procedure, and become eligible for the sale of flood insurance. VII.B.4. This...

  4. 44 CFR Appendix A(5) to Part 61 - Appendix A(5) to Part 61

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program INSURANCE... Insurance Administration Standard Flood Insurance Policy Endorsement to General Property Form This... in the inspection procedure, and become eligible for the sale of flood insurance. VII.B.4. This...

  5. 44 CFR Appendix A(4) to Part 61 - Appendix A(4) to Part 61

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program INSURANCE... Insurance Administration Standard Flood Insurance Policy Endorsement to Dwelling Form This endorsement... in the inspection procedure, and become eligible for the sale of flood insurance. VII.B.4. This...

  6. 44 CFR Appendix A(5) to Part 61 - Appendix A(5) to Part 61

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program INSURANCE... Insurance Administration Standard Flood Insurance Policy Endorsement to General Property Form This... in the inspection procedure, and become eligible for the sale of flood insurance. VII.B.4. This...

  7. 44 CFR Appendix A(5) to Part 61 - Appendix A(5) to Part 61

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program INSURANCE... Insurance Administration Standard Flood Insurance Policy Endorsement to General Property Form This... in the inspection procedure, and become eligible for the sale of flood insurance. VII.B.4. This...

  8. 44 CFR Appendix A(5) to Part 61 - Appendix A(5) to Part 61

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program INSURANCE... Insurance Administration Standard Flood Insurance Policy Endorsement to General Property Form This... in the inspection procedure, and become eligible for the sale of flood insurance. VII.B.4. This...

  9. 44 CFR Appendix A(4) to Part 61 - Appendix A(4) to Part 61

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program INSURANCE... Insurance Administration Standard Flood Insurance Policy Endorsement to Dwelling Form This endorsement... in the inspection procedure, and become eligible for the sale of flood insurance. VII.B.4. This...

  10. 44 CFR Appendix A(4) to Part 61 - Appendix A(4) to Part 61

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program INSURANCE... Insurance Administration Standard Flood Insurance Policy Endorsement to Dwelling Form This endorsement... in the inspection procedure, and become eligible for the sale of flood insurance. VII.B.4. This...

  11. 44 CFR Appendix A(5) to Part 61 - Appendix A(5) to Part 61

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program INSURANCE... Insurance Administration Standard Flood Insurance Policy Endorsement to General Property Form This... in the inspection procedure, and become eligible for the sale of flood insurance. VII.B.4. This...

  12. 49 CFR Appendix A to Part 385 - Explanation of Safety Audit Evaluation Criteria

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... safety management controls in place, is included in Appendix B, VII. List of Acute and Critical... having similar characteristics are combined together into six regulatory areas called “factors.” The regulatory factors, evaluated on the basis of the adequacy of the carrier's safety management controls, are...

  13. Digital Fingerprinting of Field Programmable Gate Arrays

    DTIC Science & Technology

    2008-03-01

    48 vii Page Appendix B . Tranistional Sampling Outputs . . . . . . . . . . . . . . 49 Appendix C. VHDL Entities...cumulative sampling outputs by pin . . . . . . . . . . . 48 B .1. FPGA outputs for Sample 0, Clk 18 . . . . . . . . . . . . . . . 49 B .2. FPGA outputs for...Sample 0, Clk 19 . . . . . . . . . . . . . . . 49 B .3. FPGA outputs for Sample 0, Clk 21 . . . . . . . . . . . . . . . 50 B .4. FPGA outputs for Sample

  14. 40 CFR Appendix Vii to Part 261 - Basis for Listing Hazardous Waste

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., acrylamide. K015 Benzyl chloride, chlorobenzene, toluene, benzotrichloride. K016 Hexachlorobenzene... Benzotrichloride, benzyl chloride, chloroform, chloromethane, chlorobenzene, 1,4-dichlorobenzene, hexachlorobenzene...

  15. 40 CFR Appendix Vii to Part 261 - Basis for Listing Hazardous Waste

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., acrylamide. K015 Benzyl chloride, chlorobenzene, toluene, benzotrichloride. K016 Hexachlorobenzene... Benzotrichloride, benzyl chloride, chloroform, chloromethane, chlorobenzene, 1,4-dichlorobenzene, hexachlorobenzene...

  16. 40 CFR Appendix Vii to Part 261 - Basis for Listing Hazardous Waste

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., acrylamide. K015 Benzyl chloride, chlorobenzene, toluene, benzotrichloride. K016 Hexachlorobenzene... Benzotrichloride, benzyl chloride, chloroform, chloromethane, chlorobenzene, 1,4-dichlorobenzene, hexachlorobenzene...

  17. 40 CFR Appendix Vii to Part 261 - Basis for Listing Hazardous Waste

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., acrylamide. K015 Benzyl chloride, chlorobenzene, toluene, benzotrichloride. K016 Hexachlorobenzene... Benzotrichloride, benzyl chloride, chloroform, chloromethane, chlorobenzene, 1,4-dichlorobenzene, hexachlorobenzene...

  18. Environmental Impact Analysis Process. Environmental Impact Statement for Realignment of Beale Air Force Base

    DTIC Science & Technology

    1990-04-01

    CONTACTED .......... 6-2 APPENDIX A.- Average Daily Air Emissions Inventory for Yuba County .............................. A-1 APPENDIX B...Civilian Wage and Salary Employment, Yuba City Metropolitan Statistical Area, 1987 (Yuba and Sutter Counties , CA) ................... 3-46 vii LIST OF...Beale AFB Students Enrolled in Yuba and Sutter County Public Schools, FY 1989-90, by Assistance Category and School Capacity ................... 3-50 4

  19. Development of a User Support Package for CPESIM II (A Computer Simulation for CPE (Computer Performance Evaluation) Use.

    DTIC Science & Technology

    1984-12-01

    Appendix D: CPESIM II Student Manual .........D-1 Appendix E: CPESIM II Instructor Manual .......E-1 Appendix F: The Abridged Report..........F-i Bibliography...operating system is implemented on. A student and instructor user’s manual is provided. vii I • - Development of a User Support Package for CPESIM II (a...was a manual one. The student changes should be collected into a database to ease the instructor workload and to provide a "history" of the evolution of

  20. Pneumatically Modulated Liquid Delivery System for Nebulizers

    DTIC Science & Technology

    2011-12-02

    VII. Acknowledgements 18 APPENDIX A: Complete Parts List 19 APPENDIX B: Source code for the Arduino Uno microcontroller (CD) 23 1 I...implemented. The Arduino Uno is a well-established hobbyist microcontroller, focused on ease-of-use and teaching non-computer programmers about embedded...circuits. The Arduino Uno uses an Atmega328 microcontroller with thirteen digital TTL control lines, six 10-bit resolution 0-5 V analog inputs, TTL

  1. 49 CFR Appendix C to Part 222 - Guide to Establishing Quiet Zones

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Guide to Establishing Quiet Zones C Appendix C to.... 222, App. C Appendix C to Part 222—Guide to Establishing Quiet Zones Introduction This Guide to... without implementation of additional safety measures at any crossings in the quiet zone; or c. Additional...

  2. Case Study of the Application of the Weapon System Warranty on the C-130 Program.

    DTIC Science & Technology

    1986-09-01

    31 Appendix A: Air Force Contract Law Center Suggested Systems Level Warranty Clauses . . . . . 33 Appendix B: Original C-130 Warranty ClauseCs...avoidance and still protect the government’s interest can work. vii This study recommends that the Department of Defense use the Air Force Contract Law Center’s...would have had the potential For allowing Lockheed to void a system level warranty had one been in effect such as the Air Force Contract Law Center’s

  3. Fe(II)- and sulfide-facilitated reduction of 99Tc(VII)O4- in microbially reduced hyporheic zone sediments

    NASA Astrophysics Data System (ADS)

    Lee, Ji-Hoon; Zachara, John M.; Fredrickson, James K.; Heald, Steve M.; McKinley, James P.; Plymale, Andrew E.; Resch, Charles T.; Moore, Dean A.

    2014-07-01

    Redox-reactive, biogeochemical phases generated by reductive microbial activity in hyporheic zone sediments from a dynamic groundwater-river interaction zone were evaluated for their ability to reduce soluble pertechnetate [99Tc(VII)O4-] to less soluble Tc(IV). The sediments were bioreduced by indigenous microorganisms that were stimulated by organic substrate addition in synthetic groundwater with or without sulfate. In most treatments, 20 μmol L-1 initial aqueous Tc(VII) was reduced to near or below detection (3.82 × 10-9 mol L-1) over periods of days to months in suspensions of variable solids concentrations. Native sediments containing significant lithogenic Fe(II) in various phases were, in contrast, unreactive with Tc(VII). The reduction rates in the bioreduced sediments increased with increases in sediment mass, in proportion to weak acid-extractable Fe(II) and sediment-associated sulfide (AVS). The rate of Tc(VII) reduction was first order with respect to both aqueous Tc(VII) concentration and sediment mass, but correlations between specific reductant concentrations and reaction rate were not found. X-ray microprobe measurements revealed a strong correlation between Tc hot spots and Fe-containing mineral particles in the sediment. However, only a portion of Fe-containing particles were Tc-hosts. The Tc-hot spots displayed a chemical signature (by EDXRF) similar to pyroxene. The application of autoradiography and electron microprobe allowed further isolation of Tc-containing particles that were invariably found to be ca 100 μm aggregates of primary mineral material embedded within a fine-grained phyllosilicate matrix. EXAFS spectroscopy revealed that the Tc(IV) within these were a combination of a Tc(IV)O2-like phase and Tc(IV)-Fe surface clusters, with a significant fraction of a TcSx-like phase in sediments incubated with SO42-. AVS was implicated as a more selective reductant at low solids concentration even though its concentration was below that required for stoichiometric reduction of Tc(VII). These results demonstrate that composite mineral aggregates may be redox reaction centers in coarse-textured hyporheic zone sediments regardless of the dominant anoxic biogeochemical processes.

  4. Fe(II)- and Sulfide-Facilitated Reduction of 99Tc(VII)O4- in Microbially Reduced Hyporheic Zone Sediments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lee, Ji-Hoon; Zachara, John M.; Fredrickson, Jim K.

    Redox-reactive, biogeochemical phases generated by reductive microbial activity in hyporheic zone sediments from a dynamic groundwater-river interaction zone were evaluated for their ability to reduce soluble pertechnetate [99Tc(VII)O4-] to less soluble Tc(IV). The sediments were bioreduced by indigenous microorganisms that were stimulated by organic substrate addition in synthetic groundwater with or without sulfate. In most treatments, 20 µmol L-1 initial aqueous Tc(VII) was reduced to near or below detection (3.82×10-9 mol L-1) over periods of days to months in suspensions of variable solids concentrations. Native sediments containing significant lithogenic Fe(II) in various phases were, in contrast, unreactive with Tc(VII). Themore » reduction rates in the bioreduced sediments increased with increases in sediment mass, in proportion to weak acid-extractable Fe(II) and sediment-associated sulfide (AVS). The rate of Tc(VII) reduction was first order with respect to both aqueous Tc(VII) concentration and sediment mass, but correlations between specific reductant concentrations and reaction rate were not found. X-ray microprobe measurements revealed a strong correlation between Tc hot spots and Fe-containing mineral particles in the sediment. However, only a portion of Fe-containing particles were Tc-hosts. The Tc-hot spots displayed a chemical signature (by EDXRF) similar to pyroxene. The application of autoradiography and electron microprobe allowed further isolation of Tc-containing particles that were invariably found to be ca 100 µm aggregates of primary mineral material embedded within a fine-grained phyllosilicate matrix. EXAFS spectroscopy revealed that the Tc(IV) within these were a combination of a Tc(IV)O2-like phase and Tc(IV)-Fe surface clusters, with a significant fraction of a TcSx-like phase in sediments incubated with SO42-. AVS was implicated as a more selective reductant at low solids concentration even though its concentration was below that required for stoichiometric reduction of Tc(VII). These results demonstrate that composite mineral aggregates may be redox reaction centers in coarse-textured hyporheic zone sediments regardless of the dominant anoxic biogeochemical processes.« less

  5. The Economy and Enlisted Retention in the Navy. Volume 2: Technical Appendixes

    DTIC Science & Technology

    2014-06-01

    Appendix C 13 Table 1. Selected summary statistics of Zone A sailors Statistic Men Women SRB 1.2 0.7 Months of sea duty in past 24 months 19.3 10.7...525,535 89,925 Appendix C 14 Table 2. Selected summary statistics of Zone B sailors Statistic Men Women SRB 1.0 0.5 Months of sea duty in...relationship holds for Zone A women as well as Zone B men and women as that found for Zone A men. Table 5. Changes in the unemployment and Treasury

  6. 15 CFR Appendix F to Subpart M of... - Davidson Seamount Management Zone

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Davidson Seamount Management Zone F Appendix F to Subpart M of Part 922 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign... Sanctuary Pt. 922, Subpt. M, App. F Appendix F to Subpart M of Part 922—Davidson Seamount Management Zone...

  7. 40 CFR Appendix Vii to Part 261 - Basis for Listing Hazardous Waste

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Tetrachloroethylene, methylene chloride trichloroethylene, 1,1,1-trichloroethane, carbon tetrachloride, chlorinated fluorocarbons. F002 Tetrachloroethylene, methylene chloride, trichloroethylene, 1,1,1-trichloroethane, 1,1,2...-dichloroethylene, 1,1-dichloroethylene, 1,1,1-trichloroethane, 1,1,2-trichloroethane, trichloroethylene, 1,1,1,2...

  8. 75 FR 42786 - Accounting Guide for LSC Recipients (2010 Edition)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ... adequate accounting and financial reporting system, including the use of specific internal controls and... the Accounting Procedures and Internal Control Checklist in Appendix VII. Sections G2, G3, and M of... the responsibilities of a recipient to maintain adequate accounting records and internal control...

  9. 32 CFR Appendix A to Part 290 - DCAA's Organization and Mission

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... practices and procedures to give advice and recommendations to procurement and contract administration... administration with financial information and advice on proposed or existing contracts and contractors, as... Counsel provides legal and legislative advice to the Director and all members of the Agency staff. (vii...

  10. Osage River Basin, Osage River, Missouri, Harry S. Trumman Dam & Reservoir. Multiple-Purpose Project. Operation and Maintenance Manual. Appendix 7, Volume 2. Construction Foundation Report.

    DTIC Science & Technology

    1984-01-01

    PROJECT S TYPE OF REPORT & PERIOD COVEREDOSAGE RIVER BASIN ConStruction Foundation OSAGE RIVER MISSOURI Report from September 1966 HARRY S. TRUMAN DAM...OPERATION AND MAINTENANCE MANUAL HARRY S. TRUMAN DAM AND RESERVOIR OSAGE RIVER, MISSOURI APPENDIX VII CONSTRUCTION FOUNDATION REPORT VOLUME II TABLE OF...09r IWNI’(ANSAS CITY M?5OU ....... 11 1 O IA R, MISSOURI HARRY S TRUMA DAM & 1K5(V01 = CONSTRUCT"ON FOUNDATION REPORT IGEOLOGIC UNIT DESCRIPTIONS

  11. 15 CFR Appendix B to Subpart M of... - Zones Within the Sanctuary Where Overflights Below 1000 Feet Are Prohibited

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Zones Within the Sanctuary Where Overflights Below 1000 Feet Are Prohibited B Appendix B to Subpart M of Part 922 Commerce and Foreign Trade... Monterey Bay National Marine Sanctuary Pt. 922, Subpt. M, App. B Appendix B to Subpart M of Part 922—Zones...

  12. 49 CFR Appendix F to Part 229 - Recommended Practices for Design and Safety Analysis

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... expected order of use; (v) Group similar controls together; (vi) Design for high stimulus-response compatibility (geometric and conceptual); (vii) Design safety-critical controls to require more than one... description of all backup methods of operation; and (s) The configuration/revision control measures designed...

  13. 49 CFR Appendix F to Part 229 - Recommended Practices for Design and Safety Analysis

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... expected order of use; (v) Group similar controls together; (vi) Design for high stimulus-response compatibility (geometric and conceptual); (vii) Design safety-critical controls to require more than one... description of all backup methods of operation; and (s) The configuration/revision control measures designed...

  14. 49 CFR Appendix F to Part 229 - Recommended Practices for Design and Safety Analysis

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... expected order of use; (v) Group similar controls together; (vi) Design for high stimulus-response compatibility (geometric and conceptual); (vii) Design safety-critical controls to require more than one... description of all backup methods of operation; and (s) The configuration/revision control measures designed...

  15. 12 CFR Appendix A to Part 701 - Federal Credit Union Bylaws

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... NCUA Regulations. (d) Report of the financial officer or the chief management official. (e) Report of... board officers of this credit union are comprised of a chair, one or more vice chairs, a financial... Directors Article VII. Board Officers, Management Officials and Executive Committee Article VIII. Credit...

  16. 77 FR 40938 - Pilot Program on NAFTA Trucking Provisions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ... regulations is included in 49 CFR part 385, Appendix B, Section VII. Parts of the FMCSRs and HMRs having similar characteristics are combined together into six regulatory areas called ``factors.'' The regulatory factors are intended to evaluate the adequacy of a carrier's management controls. M. Passed Phase 1...

  17. 78 FR 24293 - Pilot Program on NAFTA Trucking Provisions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ... Part 385, Appendix B, Section VII. Parts of the FMCSRs and HMRs having similar characteristics are combined together into six regulatory areas called ``factors.'' The regulatory factors are intended to evaluate the adequacy of a carrier's management controls. M. Passed Phase 1, Factor 1: A ``yes'' in this...

  18. 76 FR 56868 - Pilot Project on NAFTA Trucking Provisions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... part 385, Appendix B, Section VII. Parts of the FMCSRs and HMRs having similar characteristics are combined together into six regulatory areas called ``factors.'' The regulatory factors are intended to evaluate the adequacy of a carrier's management controls. L. Passed Phase 1, Factor 1: A ``yes'' in this...

  19. 77 FR 12356 - Pilot Program on NAFTA Trucking Provisions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ... part 385, Appendix B, Section VII. Parts of the FMCSRs and HMRs having similar characteristics are combined together into six regulatory areas called ``factors.'' The regulatory factors are intended to evaluate the adequacy of a carrier's management controls. M. Passed Phase 1, Factor 1: A ``yes'' in this...

  20. 12 CFR Appendix B to Part 1720 - Policy Guidance; Non-Mortgage Liquidity Investments

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... control standards; v. The limits structure; vi. The performance standards and measures; and vii. The... risk oversight group. f. The Enterprise should adopt a limit structure to promote diversification in..., management should consider the discrete risks associated with the non-mortgage liquidity investment portfolio...

  1. 12 CFR Appendix B to Part 1720 - Policy Guidance; Non-Mortgage Liquidity Investments

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... control standards; v. The limits structure; vi. The performance standards and measures; and vii. The... risk oversight group. f. The Enterprise should adopt a limit structure to promote diversification in..., management should consider the discrete risks associated with the non-mortgage liquidity investment portfolio...

  2. 12 CFR Appendix B to Part 1720 - Policy Guidance; Non-Mortgage Liquidity Investments

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... control standards; v. The limits structure; vi. The performance standards and measures; and vii. The... risk oversight group. f. The Enterprise should adopt a limit structure to promote diversification in..., management should consider the discrete risks associated with the non-mortgage liquidity investment portfolio...

  3. 12 CFR Appendix B to Part 1720 - Policy Guidance; Non-Mortgage Liquidity Investments

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... control standards; v. The limits structure; vi. The performance standards and measures; and vii. The... risk oversight group. f. The Enterprise should adopt a limit structure to promote diversification in..., management should consider the discrete risks associated with the non-mortgage liquidity investment portfolio...

  4. 15 CFR 400.24 - Application for zone.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...; (vii) If part of a port facility, a summary of port and transportation services and facilities; if not... from those firms that are considered prime prospects; and (vii) A description of proposed manufacturing and processing operations, if applicable, with information covering the factors described in § 400.31...

  5. 15 CFR Appendix Vii to Subpart P... - Areas To Be Avoided Boundary Coordinates

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ....10′ W In the Vicinity of Key West Harbor [Reference Chart: United States 11434, 21st Edition—August... COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT NATIONAL MARINE SANCTUARY PROGRAM REGULATIONS Florida Keys... Avoided Boundary Coordinates In The Vicinity of the Florida Keys [Reference Charts: United States 11466...

  6. 76 FR 56272 - Pilot Project on NAFTA Trucking Provisions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-12

    ... controls. A list of acute and critical regulations is included in 49 CFR part 385, Appendix B, Section VII... areas called ``factors.'' The regulatory factors are intended to evaluate the adequacy of a carrier's management controls. L. Passed Phase 1, Factor 1: A ``yes'' in this column indicates the carrier has...

  7. 14 CFR Appendix B to Part 29 - Airworthiness Criteria for Helicopter Instrument Flight

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... Dynamic stability. (a) Any oscillation having a period of less than 5 seconds must damp to 1/2 amplitude... achieve double amplitude in less than 9 seconds. VII. Stability Augmentation System (SAS) (a) If a SAS is... control system must be considered. In addition— (i) The controllability and maneuverability requirements...

  8. 40 CFR 63.788 - Recordkeeping and reporting requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... containers meet the standards as described in § 63.783(b)(2); and (vii) The results of any Method 24 of appendix A to 40 CFR part 60 or approved VOHAP measurement test conducted on individual containers of... summary of the number and total duration of incidents that the monitoring protocol failed to perform in...

  9. An Extended Multi-Zone Model for the MCG-6-30-15 Warm Absorber

    NASA Technical Reports Server (NTRS)

    Morales, R.; Fabian, A. C.; Reynolds, C. S.

    2000-01-01

    The variable warm absorber seen with ASCA in the X-ray spectrum of MCG 6-30-15 shows complex time behaviour in which the optical depth of O VIII anticorrelates with the flux whereas that of O VII is unchanging. The explanation in terms of a two zone absorber has since been challenged by BeppoSAX observations. These present a more complicated behaviour for the O VII edge. The explanation we offer for both ASCA and BeppoSAX observations requires a very simple photoionization model together with the presence of a third, intermediate, zone and a period of very low luminosity. In practice warm absorbers are likely to be extended, multi-zone regions of which only part causes directly observable absorption edges at any given time depending on the value of the luminosity.

  10. An autotrophic H 2 -oxidizing, nitrate-respiring, Tc(VII)-reducing A cidovorax sp. isolated from a subsurface oxic-anoxic transition zone: H 2 -oxidizing, Tc-reducing Acidovorax spp.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lee, Ji-Hoon; Fredrickson, James K.; Plymale, Andrew E.

    2015-04-08

    Increasing concentrations of H 2 with depth were observed across a geologic unconformity and associated redox transition zone in the subsurface at the Hanford Site in south-central Washington, USA. An opposing gradient characterized by decreasing O 2 and nitrate concentrations was consistent with microbial-catalyzed biogeochemical processes. Sterile sand was incubated in situ within a multi-level sampler placed across the redox transition zone to evaluate the potential for Tc(VII) reduction and for enrichment of H 2-oxidizing denitrifiers capable of reducing Tc(VII). H 2-driven TcO 4- reduction was detected in sand incubated at all depths but was strongest in material from amore » depth of 17.1 m. Acidovorax spp. were isolated from H 2-nitrate enrichments from colonized sand from 15.1 m, with one representative, strain JHL-9, subsequently characterized. JHL-9 grew on acetate with either O 2 or nitrate as electron acceptor (data not shown) and on medium with bicarbonate, H 2 and nitrate. JHL-9 also reduced pertechnetate (TcO 4-) under denitrifying conditions with H 2 as the electron donor. H 2-oxidizing Acidovorax spp. in the subsurface at Hanford and other locations may contribute to the maintenance of subsurface redox gradients and offer the potential for Tc(VII) reduction.« less

  11. 32 CFR Appendix C to Part 110 - Application of Basic Course Formula (Male and Female Members) (Sample)

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Application of Basic Course Formula (Male and Female Members) (Sample) C Appendix C to Part 110 National Defense Department of Defense OFFICE OF THE... Appendix C to Part 110—Application of Basic Course Formula (Male and Female Members) (Sample) Zone I Zone...

  12. 32 CFR Appendix E to Part 110 - Application of 4-Week Summer Field Training Formula (Sample)

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Application of 4-Week Summer Field Training Formula (Sample) E Appendix E to Part 110 National Defense Department of Defense OFFICE OF THE SECRETARY... Appendix E to Part 110—Application of 4-Week Summer Field Training Formula (Sample) Zone I Zone II Total...

  13. 32 CFR Appendix E to Part 110 - Application of 4-Week Summer Field Training Formula (Sample)

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Application of 4-Week Summer Field Training Formula (Sample) E Appendix E to Part 110 National Defense Department of Defense OFFICE OF THE SECRETARY... Appendix E to Part 110—Application of 4-Week Summer Field Training Formula (Sample) Zone I Zone II Total...

  14. 32 CFR Appendix E to Part 110 - Application of 4-Week Summer Field Training Formula (Sample)

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Application of 4-Week Summer Field Training Formula (Sample) E Appendix E to Part 110 National Defense Department of Defense OFFICE OF THE SECRETARY... Appendix E to Part 110—Application of 4-Week Summer Field Training Formula (Sample) Zone I Zone II Total...

  15. 32 CFR Appendix E to Part 110 - Application of 4-Week Summer Field Training Formula (Sample)

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Application of 4-Week Summer Field Training Formula (Sample) E Appendix E to Part 110 National Defense Department of Defense OFFICE OF THE SECRETARY... Appendix E to Part 110—Application of 4-Week Summer Field Training Formula (Sample) Zone I Zone II Total...

  16. 32 CFR Appendix E to Part 110 - Application of 4-Week Summer Field Training Formula (Sample)

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Formula (Sample) E Appendix E to Part 110 National Defense Department of Defense OFFICE OF THE SECRETARY... COMMUTATION INSTEAD OF UNIFORMS FOR MEMBERS OF THE SENIOR RESERVE OFFICERS' TRAINING CORPS Pt. 110, App. E Appendix E to Part 110—Application of 4-Week Summer Field Training Formula (Sample) Zone I Zone II Total...

  17. 32 CFR Appendix C to Part 110 - Application of Basic Course Formula (Male and Female Members) (Sample)

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Female Members) (Sample) C Appendix C to Part 110 National Defense Department of Defense OFFICE OF THE... COMMUTATION INSTEAD OF UNIFORMS FOR MEMBERS OF THE SENIOR RESERVE OFFICERS' TRAINING CORPS Pt. 110, App. C Appendix C to Part 110—Application of Basic Course Formula (Male and Female Members) (Sample) Zone I Zone...

  18. 15 CFR Appendix C to Subpart H of... - No-Anchoring Seagrass Protection Zones in Tomales Bay

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false No-Anchoring Seagrass Protection Zones in Tomales Bay C Appendix C to Subpart H of Part 922 Commerce and Foreign Trade Regulations Relating... of the Farallones National Marine Sanctuary Pt. 922, Subpt. H, App. C Appendix C to Subpart H of Part...

  19. MIZEX: A Program for Mesoscale Air-Ice-Ocean Interaction Experiments in Arctic Marginal Ice Zones. MIZEX Bulletin VII.

    DTIC Science & Technology

    1986-03-01

    8217 ILI L2.2363 31-25 UICRQCCW p O TEST C4ART’OPSMa, -f AoA IV 4 86 9 ’ 5 MIZEX BULLETIN SERIES: INFORMATION FOR CONTRIBUTORS The main purpose of the...Ice-Ocean Interaction Experiments in Arctic Marginal Ice Zones MIZEX BULLETIN VII LEC T E SEP 2 9 1986 ’Jl P March 1986 J A ’QOzltnal OontsSn$ ooLoP...studies in both the northern and southern hemispheres. W.D. HIBLER Ill March 1986 ii CONTENTS* Page P reface

  20. Sand Waves in Tidal Channels

    DTIC Science & Technology

    2007-01-01

    sincerely thank Steven Borgeld, from Humboldt State University, for providing the grain size data for the Humboldt Entrance Channel. iv SAND...Wave Characteristics at Moriches Inlet... 182 APPENDIX VII – Sediment Data , Humboldt Entrance Channel, CA ........................... 186 References...waves may be limited by wave action, sand supply, and dredging activity. Bathymetric data collected at Humboldt Inlet, California, show sand waves

  1. 77 FR 24436 - Approval and Promulgation of Air Quality Implementation Plans; Wisconsin; Milwaukee-Racine...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-24

    .... How did EPA address missing data? V. Proposed Action VI. What is the effect of this action? VII.... ** Indicates incomplete data due to monitor shut down. IV. How did EPA address missing data? Appendix N of 40... in Milwaukee, where there are missing or incomplete data due to monitor shutdown or other factors...

  2. 14 CFR Appendix A to Part 43 - Major Alterations, Major Repairs, and Preventive Maintenance

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... hub design. (iii) Changes in the governor or control design. (iv) Installation of a propeller governor.... (iv) Engine mounts. (v) Control system. (vi) Landing gear. (vii) Hull or floats. (viii) Elements of an... of gravity limits of the aircraft. (xii) Changes to the basic design of the fuel, oil, cooling...

  3. Ice-VII inclusions in diamonds: Evidence for aqueous fluid in Earth’s deep mantle

    NASA Astrophysics Data System (ADS)

    Tschauner, O.; Huang, S.; Greenberg, E.; Prakapenka, V. B.; Ma, C.; Rossman, G. R.; Shen, A. H.; Zhang, D.; Newville, M.; Lanzirotti, A.; Tait, K.

    2018-03-01

    Water-rich regions in Earth’s deeper mantle are suspected to play a key role in the global water budget and the mobility of heat-generating elements. We show that ice-VII occurs as inclusions in natural diamond and serves as an indicator for such water-rich regions. Ice-VII, the residue of aqueous fluid present during growth of diamond, crystallizes upon ascent of the host diamonds but remains at pressures as high as 24 gigapascals; it is now recognized as a mineral by the International Mineralogical Association. In particular, ice-VII in diamonds points toward fluid-rich locations in the upper transition zone and around the 660-kilometer boundary.

  4. Type VII Collagen Expression in the Human Vitreoretinal Interface, Corpora Amylacea and Inner Retinal Layers

    PubMed Central

    Wullink, Bart; Pas, Hendri H.; Van der Worp, Roelofje J.; Kuijer, Roel; Los, Leonoor I.

    2015-01-01

    Type VII collagen, as a major component of anchoring fibrils found at basement membrane zones, is crucial in anchoring epithelial tissue layers to their underlying stroma. Recently, type VII collagen was discovered in the inner human retina by means of immunohistochemistry, while proteomic investigations demonstrated type VII collagen at the vitreoretinal interface of chicken. Because of its potential anchoring function at the vitreoretinal interface, we further assessed the presence of type VII collagen at this site. We evaluated the vitreoretinal interface of human donor eyes by means of immunohistochemistry, confocal microscopy, immunoelectron microscopy, and Western blotting. Firstly, type VII collagen was detected alongside vitreous fibers6 at the vitreoretinal interface. Because of its known anchoring function, it is likely that type VII collagen is involved in vitreoretinal attachment. Secondly, type VII collagen was found within cytoplasmic vesicles of inner retinal cells. These cells resided most frequently in the ganglion cell layer and inner plexiform layer. Thirdly, type VII collagen was found in astrocytic cytoplasmic inclusions, known as corpora amylacea. The intraretinal presence of type VII collagen was confirmed by Western blotting of homogenized retinal preparations. These data add to the understanding of vitreoretinal attachment, which is important for a better comprehension of common vitreoretinal attachment pathologies. PMID:26709927

  5. 40 CFR Appendix C to Part 63 - Determination of the Fraction Biodegraded (Fbio) in a Biological Treatment Unit

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... designed and operated to approach or achieve uniform biomass distribution and organic compound... required by the rule. Unless otherwise specified, the procedures presented in this appendix are designed to... subdivided into a series of zones that have uniform characteristics within each zone. The number of zones...

  6. 40 CFR Appendix C to Part 63 - Determination of the Fraction Biodegraded (Fbio) in a Biological Treatment Unit

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... designed and operated to approach or achieve uniform biomass distribution and organic compound... required by the rule. Unless otherwise specified, the procedures presented in this appendix are designed to... subdivided into a series of zones that have uniform characteristics within each zone. The number of zones...

  7. 40 CFR Appendix C to Part 63 - Determination of the Fraction Biodegraded (Fbio) in a Biological Treatment Unit

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... designed and operated to approach or achieve uniform biomass distribution and organic compound... required by the rule. Unless otherwise specified, the procedures presented in this appendix are designed to... subdivided into a series of zones that have uniform characteristics within each zone. The number of zones...

  8. 40 CFR Appendix C to Part 63 - Determination of the Fraction Biodegraded (Fbio) in a Biological Treatment Unit

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... designed and operated to approach or achieve uniform biomass distribution and organic compound... required by the rule. Unless otherwise specified, the procedures presented in this appendix are designed to... subdivided into a series of zones that have uniform characteristics within each zone. The number of zones...

  9. 40 CFR Appendix C to Part 63 - Determination of the Fraction Biodegraded (Fbio) in a Biological Treatment Unit

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... designed and operated to approach or achieve uniform biomass distribution and organic compound... required by the rule. Unless otherwise specified, the procedures presented in this appendix are designed to... subdivided into a series of zones that have uniform characteristics within each zone. The number of zones...

  10. 29 CFR Appendix D to Subpart R of... - Illustration of the Use of Control Lines To Demarcate Controlled Decking Zones (CDZs): Non...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Controlled Decking Zones (CDZs): Non-mandatory Guidelines for Complying With § 1926.760(c)(3) D Appendix D... of Control Lines To Demarcate Controlled Decking Zones (CDZs): Non-mandatory Guidelines for Complying..., tapes, or equivalent materials, and supporting stanchions as follows: (i) Each line is rigged and...

  11. 29 CFR Appendix D to Subpart R of... - Illustration of the Use of Control Lines To Demarcate Controlled Decking Zones (CDZs): Non...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Controlled Decking Zones (CDZs): Non-mandatory Guidelines for Complying With § 1926.760(c)(3) D Appendix D... of Control Lines To Demarcate Controlled Decking Zones (CDZs): Non-mandatory Guidelines for Complying..., tapes, or equivalent materials, and supporting stanchions as follows: (i) Each line is rigged and...

  12. 40 CFR Appendix Vii to Part 266 - Health-Based Limits for Exclusion of Waste-Derived Residues*

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Constituent CAS No. Concentration limits (mg/L) Antimony 7440-36-0 1xE+00 Arsenic 7440-38-2 5xE+00 Barium 7440... alcohol 107-18-6 2xE−01 Aluminum phosphide 20859-73-8 1xE−02 Aniline 62-53-3 6xE−02 Barium cyanide 542-62...

  13. 40 CFR Appendix Vii to Part 86 - Standard Bench Cycle (SBC)

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... procedures [Ref. § 86.1823-08(d)] consist of aging a catalyst-oxygen-sensor system on an aging bench which... bench with an engine as the source of feed gas for the catalyst. 3. The SBC is a 60-second cycle which... occurs in the hottest catalyst. Alternatively, the feed gas temperature may be measured and converted to...

  14. 40 CFR Appendix Vii to Part 86 - Standard Bench Cycle (SBC)

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... procedures [Ref. § 86.1823-08(d)] consist of aging a catalyst-oxygen-sensor system on an aging bench which... bench with an engine as the source of feed gas for the catalyst. 3. The SBC is a 60-second cycle which... occurs in the hottest catalyst. Alternatively, the feed gas temperature may be measured and converted to...

  15. 40 CFR Appendix Vii to Part 266 - Health-Based Limits for Exclusion of Waste-Derived Residues*

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-chloroethyl) ether 111-44-4 3xE−04 Bis(chloromethyl) ether 542-88-1 2xE−06 Bis(2-ethylhexyl) phthalate 117-81...-57-1 2xE−05 Diethyl phthalate 84-66-2 3xE+01 Diethylstilbesterol 56-53-1 7xE−07 Dimethoate 60-51-5 3x...

  16. 40 CFR Appendix Vii to Part 266 - Health-Based Limits for Exclusion of Waste-Derived Residues*

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-chloroethyl) ether 111-44-4 3xE−04 Bis(chloromethyl) ether 542-88-1 2xE−06 Bis(2-ethylhexyl) phthalate 117-81...-57-1 2xE−05 Diethyl phthalate 84-66-2 3xE+01 Diethylstilbesterol 56-53-1 7xE−07 Dimethoate 60-51-5 3x...

  17. 40 CFR Appendix Vii to Part 266 - Health-Based Limits for Exclusion of Waste-Derived Residues*

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-chloroethyl) ether 111-44-4 3xE−04 Bis(chloromethyl) ether 542-88-1 2xE−06 Bis(2-ethylhexyl) phthalate 117-81...-57-1 2xE−05 Diethyl phthalate 84-66-2 3xE+01 Diethylstilbesterol 56-53-1 7xE−07 Dimethoate 60-51-5 3x...

  18. 40 CFR Appendix Vii to Part 266 - Health-Based Limits for Exclusion of Waste-Derived Residues*

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...-chloroethyl) ether 111-44-4 3xE−04 Bis(chloromethyl) ether 542-88-1 2xE−06 Bis(2-ethylhexyl) phthalate 117-81...-57-1 2xE−05 Diethyl phthalate 84-66-2 3xE+01 Diethylstilbesterol 56-53-1 7xE−07 Dimethoate 60-51-5 3x...

  19. Brazilian Arms Production: Partial Dependence

    DTIC Science & Technology

    1988-09-01

    neighbors, before the Great Depression Brazil relied upon the export of primary commodities such as coffee, sugar and cocoa for its hard currency...24 Conclusions 26 Appendix 29 - VII - TABLES A.l. Brazilian arms exports and imports, 1968-86 30 A.2. Destination of...Embracr aircraft delivered outside of Brazil, 1975- 83 31 FIGURE 1. Brazilian arms exports and imports, 1968-86 25 IX - ACKNOWLEDGMENTS

  20. 29 CFR Appendix D to Subpart R of... - Illustration of the Use of Control Lines To Demarcate Controlled Decking Zones (CDZs): Non...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of Control Lines To Demarcate Controlled Decking Zones (CDZs): Non-mandatory Guidelines for Complying... 29 Labor 8 2012-07-01 2012-07-01 false Illustration of the Use of Control Lines To Demarcate Controlled Decking Zones (CDZs): Non-mandatory Guidelines for Complying With § 1926.760(c)(3) D Appendix D...

  1. 29 CFR Appendix D to Subpart R of... - Illustration of the Use of Control Lines To Demarcate Controlled Decking Zones (CDZs): Non...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of Control Lines To Demarcate Controlled Decking Zones (CDZs): Non-mandatory Guidelines for Complying... 29 Labor 8 2010-07-01 2010-07-01 false Illustration of the Use of Control Lines To Demarcate Controlled Decking Zones (CDZs): Non-mandatory Guidelines for Complying With § 1926.760(c)(3) D Appendix D...

  2. 29 CFR Appendix D to Subpart R of... - Illustration of the Use of Control Lines To Demarcate Controlled Decking Zones (CDZs): Non...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of Control Lines To Demarcate Controlled Decking Zones (CDZs): Non-mandatory Guidelines for Complying... 29 Labor 8 2013-07-01 2013-07-01 false Illustration of the Use of Control Lines To Demarcate Controlled Decking Zones (CDZs): Non-mandatory Guidelines for Complying With § 1926.760(c)(3) D Appendix D...

  3. 29 CFR Appendix to Part 1604 - Questions and Answers on the Pregnancy Discrimination Act, Public Law 95-555, 92 Stat. 2076 (1978)

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GUIDELINES ON DISCRIMINATION BECAUSE OF SEX Pt. 1604, App... prohibits, among other things, discrimination in employment on the basis of sex. The Pregnancy Discrimination Act makes it clear that “because of sex” or “on the basis of sex”, as used in title VII, includes...

  4. 49 CFR Appendix B to Part 238 - Test Methods and Performance Criteria for the Flammability and Smoke Emission Characteristics of...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Flammability of Flexible Cellular Materials Using a Radiant Heat Energy Source. (v) ASTM E 119-00a, Standard... Method for Surface Flammability of Materials Using a Radiant Heat Energy Source. (vii) ASTM E 648-00, Standard Test Method for Critical Radiant Flux of Floor-Covering Systems Using a Radiant Heat Energy Source...

  5. 49 CFR Appendix B to Part 238 - Test Methods and Performance Criteria for the Flammability and Smoke Emission Characteristics of...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Flammability of Flexible Cellular Materials Using a Radiant Heat Energy Source. (v) ASTM E 119-00a, Standard... Method for Surface Flammability of Materials Using a Radiant Heat Energy Source. (vii) ASTM E 648-00, Standard Test Method for Critical Radiant Flux of Floor-Covering Systems Using a Radiant Heat Energy Source...

  6. 49 CFR Appendix B to Part 238 - Test Methods and Performance Criteria for the Flammability and Smoke Emission Characteristics of...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Flammability of Flexible Cellular Materials Using a Radiant Heat Energy Source. (v) ASTM E 119-00a, Standard... Method for Surface Flammability of Materials Using a Radiant Heat Energy Source. (vii) ASTM E 648-00, Standard Test Method for Critical Radiant Flux of Floor-Covering Systems Using a Radiant Heat Energy Source...

  7. 49 CFR Appendix B to Part 238 - Test Methods and Performance Criteria for the Flammability and Smoke Emission Characteristics of...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Flammability of Flexible Cellular Materials Using a Radiant Heat Energy Source. (v) ASTM E 119-00a, Standard... Method for Surface Flammability of Materials Using a Radiant Heat Energy Source. (vii) ASTM E 648-00, Standard Test Method for Critical Radiant Flux of Floor-Covering Systems Using a Radiant Heat Energy Source...

  8. 49 CFR Appendix C to Part 222 - Guide to Establishing Quiet Zones

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Guide to Establishing Quiet Zones C Appendix C to Part 222 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION USE OF LOCOMOTIVE HORNS AT PUBLIC HIGHWAY-RAIL GRADE CROSSINGS Pt...

  9. 49 CFR Appendix C to Part 222 - Guide to Establishing Quiet Zones

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Guide to Establishing Quiet Zones C Appendix C to Part 222 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION USE OF LOCOMOTIVE HORNS AT PUBLIC HIGHWAY-RAIL GRADE CROSSINGS Pt...

  10. 49 CFR Appendix C to Part 222 - Guide to Establishing Quiet Zones

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Guide to Establishing Quiet Zones C Appendix C to Part 222 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION USE OF LOCOMOTIVE HORNS AT PUBLIC HIGHWAY-RAIL GRADE CROSSINGS Pt...

  11. 49 CFR Appendix C to Part 222 - Guide to Establishing Quiet Zones

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Horns will not be subject to annual reviews. (5) The use of FRA's web-based Quiet Zone Calculator is... appendix A (e.g., shorter than required traffic channelization devices), non-engineering ASMs (e.g., programmed law enforcement), and engineering ASMs (i.e., engineering improvements other than modified SSMs...

  12. 15 CFR Appendix F to Subpart M of... - Davidson Seamount Management Zone

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Davidson Seamount Management Zone F Appendix F to Subpart M of Part 922 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND...

  13. Ice-VII inclusions in diamonds: Evidence for aqueous fluid in Earth's deep mantle.

    PubMed

    Tschauner, O; Huang, S; Greenberg, E; Prakapenka, V B; Ma, C; Rossman, G R; Shen, A H; Zhang, D; Newville, M; Lanzirotti, A; Tait, K

    2018-03-09

    Water-rich regions in Earth's deeper mantle are suspected to play a key role in the global water budget and the mobility of heat-generating elements. We show that ice-VII occurs as inclusions in natural diamond and serves as an indicator for such water-rich regions. Ice-VII, the residue of aqueous fluid present during growth of diamond, crystallizes upon ascent of the host diamonds but remains at pressures as high as 24 gigapascals; it is now recognized as a mineral by the International Mineralogical Association. In particular, ice-VII in diamonds points toward fluid-rich locations in the upper transition zone and around the 660-kilometer boundary. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

  14. Domestic Aluminum Resources: Dilemmas of Development. Volume II. Appendixes II-VII. Detailed Agency Comments and GAO Response.

    DTIC Science & Technology

    1980-07-17

    31 Clay/hydrochloric acid, gas - induced crystallization 32 Clay/nitric acid evaporative crystallization 32 Clay/hydrochloric acid, evapora- tive...ALUMINA AND ALUMINUM TECHNOLOGIES 53 Evaluation of nonbauxitic alumina production processes 54 Clay/carbo-chlorination 54 Clay/hydrochloric acid, gas ...reports that the miniplant program is centered on a single process-- clay/hydrochloric acid- gas precipitation. The Bureau of Mines has not retreated

  15. Investigations Concerning Hydrolysis and Stabilization of Antiradiation Compounds

    DTIC Science & Technology

    1982-01-01

    a. HPLC Unit A 3 b. HPLC Unit B 3 c. Solvents 3 d. Reagents 3 B. In Vivo Studies 3 C. Microencapsulation 4 1. Materials 4 a... Microencapsulation 63 VI. CONCLUSIONS 64 VII. RECOMMENDATIONS 65 LITERATURE CITED 66 APPENDU A - IN VIVO PILOT STUDIES 67 APPENDIX B...stomach. One convenient method of applying such a coating is microencapsulation , a process which may subject the drug to elevated temperatures

  16. 40 CFR Appendix Vii to Part 268 - LDR Effective Dates of Surface Disposed Prohibited Hazardous Wastes

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Dates of Surface Disposed Wastes (Non-Soil and Debris) Regulated in the LDRS a—Comprehensive List Waste... radioactive wastes June 30, 1994. F039 Wastewater Aug. 8, 1990. F039 Nonwastewater May 8, 1992. K001 (organics.... K085 All Aug. 8, 1990. K086 (organics) b All Aug. 8, 1988. K086 All others Aug. 8, 1988. K087 All Aug...

  17. 40 CFR Appendix Vii to Part 268 - LDR Effective Dates of Surface Disposed Prohibited Hazardous Wastes

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Dates of Surface Disposed Wastes (Non-Soil and Debris) Regulated in the LDRS a—Comprehensive List Waste... radioactive wastes June 30, 1994. F039 Wastewater Aug. 8, 1990. F039 Nonwastewater May 8, 1992. K001 (organics.... K085 All Aug. 8, 1990. K086 (organics) b All Aug. 8, 1988. K086 All others Aug. 8, 1988. K087 All Aug...

  18. 40 CFR Appendix Vii to Part 268 - LDR Effective Dates of Surface Disposed Prohibited Hazardous Wastes

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Dates of Surface Disposed Wastes (Non-Soil and Debris) Regulated in the LDRS a—Comprehensive List Waste... radioactive wastes June 30, 1994. F039 Wastewater Aug. 8, 1990. F039 Nonwastewater May 8, 1992. K001 (organics.... K085 All Aug. 8, 1990. K086 (organics) b All Aug. 8, 1988. K086 All others Aug. 8, 1988. K087 All Aug...

  19. 40 CFR Appendix Vii to Part 268 - LDR Effective Dates of Surface Disposed Prohibited Hazardous Wastes

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Dates of Surface Disposed Wastes (Non-Soil and Debris) Regulated in the LDRS a—Comprehensive List Waste... radioactive wastes June 30, 1994. F039 Wastewater Aug. 8, 1990. F039 Nonwastewater May 8, 1992. K001 (organics.... K085 All Aug. 8, 1990. K086 (organics) b All Aug. 8, 1988. K086 All others Aug. 8, 1988. K087 All Aug...

  20. 40 CFR Appendix Vii to Part 268 - LDR Effective Dates of Surface Disposed Prohibited Hazardous Wastes

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Dates of Surface Disposed Wastes (Non-Soil and Debris) Regulated in the LDRS a—Comprehensive List Waste... radioactive wastes June 30, 1994. F039 Wastewater Aug. 8, 1990. F039 Nonwastewater May 8, 1992. K001 (organics.... K085 All Aug. 8, 1990. K086 (organics) b All Aug. 8, 1988. K086 All others Aug. 8, 1988. K087 All Aug...

  1. 15 CFR Appendix E to Subpart M of... - Motorized Personal Watercraft Zones and Access Routes Within the Sanctuary

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Motorized Personal Watercraft Zones and Access Routes Within the Sanctuary E Appendix E to Subpart M of Part 922 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC...

  2. Tectonic Divisions Based on Gravity Data and Earthquake Distribution Characteristics in the North South Seismic Belt, China

    NASA Astrophysics Data System (ADS)

    Tian, T.; Zhang, J.; Jiang, W.

    2017-12-01

    The North South Seismic Belt is located in the middle of China, and this seismic belt can be divided into 12 tectonic zones, including the South West Yunnan (I), the Sichuan Yunnan (II), the Qiang Tang (III), the Bayan Har (IV), the East Kunlun Qaidam (V), the Qi Lian Mountain (VI), the Tarim(VII), the East Alashan (VIII), the East Sichuan (IX), the Ordos(X), the Middle Yangtze River (XI) and the Edge of Qinghai Tibet Block (XII) zone. Based on the Bouguer Gravity data calculated from the EGM2008 model, the Euler deconvolution was used to obtain the edge of tectonic zone to amend the traditional tectonic divisions. In every tectonic zone and the whole research area, the logarithm of the total energy of seismic was calculated. The Time Series Analysis (TSA) for all tectonic zones and the whole area were progressed in R, and 12 equal divisions were made (A1-3, B1-3, C1-3, D1-3) by latitude and longitude as a control group. A simple linear trend fitting of time was used, and the QQ figure was used to show the residual distribution features. Among the zones according to Gravity anomalies, I, II and XII show similar statistical characteristic, with no earthquake free year (on which year there was no earthquake in the zone), and it shows that the more seismic activity area is more similar in statistical characteristic as the large area, no matter how large the zone is or how many earthquakes are in the zone. Zone IV, V, IX, III, VII and VIII show one or several seismic free year during 1970s (IV, V and IX) and 1980s (III, VII and VIII), which may implicate the earthquake activity were low decades ago or the earthquake catalogue were not complete in these zones, or both. Zone VI, X and XI show many earthquake free years even in this decade, which means in these zones the earthquake activity were very low even if the catalogue were not complete. In the control group, the earthquake free year zone appeared random and independent of the seismic density, and in all equal divided zones with seismic free years, the seismic free years all appeared in 1970s, which only related to the incompleteness of the earthquake catalogue in the west area of China. In conclusion, the tectonic divisions based on Gravity anomalies can provide a more efficient way to add space factor in the time series analysis with specific tectonic implications.

  3. 15 CFR Appendix B to Subpart M of... - Zones Within the Sanctuary Where Overflights Below 1000 Feet Are Prohibited

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Zones Within the Sanctuary Where Overflights Below 1000 Feet Are Prohibited B Appendix B to Subpart M of Part 922 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION...

  4. SupportNet for Frontline Behavioral Health Providers

    DTIC Science & Technology

    2013-07-01

    hired. (Objective 3) d) We have facilitated six, on -site Focus Group meetings at Fort Carson. (Objective 3) (Appendix VII) e) We have reviewed the...Based on these results, the final model with factor loadings and the covariance constrained to be equal across both groups (Model 6; Table 3) was...and 2.17 hours of group clinical supervision per month. On average, they were receiving peer support by discussing the patients with colleagues on

  5. 15 CFR Appendix Vii to Subpart P... - Areas To Be Avoided Boundary Coordinates

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ....50′N 80°07.00′W 22 25°39.70′N 80°06.85′W 23 25°45.00′N 80°06.10′W In the Vicinity of Key West Harbor... COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT NATIONAL MARINE SANCTUARY PROGRAM REGULATIONS Florida Keys... Avoided Boundary Coordinates In The Vicinity of the Florida Keys [Reference Charts: United States 11466...

  6. 15 CFR Appendix Vii to Subpart P... - Areas To Be Avoided Boundary Coordinates

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ....50′N 80°07.00′W 22 25°39.70′N 80°06.85′W 23 25°45.00′N 80°06.10′W In the Vicinity of Key West Harbor... COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT NATIONAL MARINE SANCTUARY PROGRAM REGULATIONS Florida Keys... Avoided Boundary Coordinates In The Vicinity of the Florida Keys [Reference Charts: United States 11466...

  7. 15 CFR Appendix Vii to Subpart P... - Areas To Be Avoided Boundary Coordinates

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ....50′N 80°07.00′W 22 25°39.70′N 80°06.85′W 23 25°45.00′N 80°06.10′W In the Vicinity of Key West Harbor... COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT NATIONAL MARINE SANCTUARY PROGRAM REGULATIONS Florida Keys... Avoided Boundary Coordinates In The Vicinity of the Florida Keys [Reference Charts: United States 11466...

  8. 15 CFR Appendix Vii to Subpart P... - Areas To Be Avoided Boundary Coordinates

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ....50′N 80°07.00′W 22 25°39.70′N 80°06.85′W 23 25°45.00′N 80°06.10′W In the Vicinity of Key West Harbor... COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT NATIONAL MARINE SANCTUARY PROGRAM REGULATIONS Florida Keys... Avoided Boundary Coordinates In The Vicinity of the Florida Keys [Reference Charts: United States 11466...

  9. Defense Acquisition Workforce: Better Identification, Development, and Oversight Needed for Personnel Involved in Acquiring Services

    DTIC Science & Technology

    2011-09-01

    suggestions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway...maintenance or operations support for a missile range to grass cutting, and many things in between. According to the Defense Science Board, buying...may be found on the last Belva M. Martin page of this report. Staff acknowledgements are listed in appendix VII. t Director, Acquisition and

  10. Single Crystal Diffractometry

    NASA Astrophysics Data System (ADS)

    Arndt, U. W.; Willis, B. T. M.

    2009-06-01

    Preface; Acknowledgements; Part I. Introduction; Part II. Diffraction Geometry; Part III. The Design of Diffractometers; Part IV. Detectors; Part V. Electronic Circuits; Part VI. The Production of the Primary Beam (X-rays); Part VII. The Production of the Primary Beam (Neutrons); Part VIII. The Background; Part IX. Systematic Errors in Measuring Relative Integrated Intensities; Part X. Procedure for Measuring Integrated Intensities; Part XI. Derivation and Accuracy of Structure Factors; Part XII. Computer Programs and On-line Control; Appendix; References; Index.

  11. Military Operations in Selected Lebanese Built-Up Areas, 1975 - 1978

    DTIC Science & Technology

    1979-06-01

    highway. July 21, 1976 Forces: Saudi Arabian members of the Arab peacekeeping forces v. Christian militiamen of the NLP Sector: the museum at the...predominantly Arab country located on the eastern Mediterranean shore. It is heavily Westernized, and the capital, Beirut (pop. about 800,000 to 1,000,000), is...APPENDIX D. PHOTOGRAPHS APPEN•DIX E. QUESTIONNAIRE vii ABBREVIATIONS AAA Anti-Aircraft Artillery AT Anti-Tank ADF Arab Deterrent Force ALF Arab Liberation

  12. Duped by the Frailty Myth: USMC Gender Based Physical Fitness Standards

    DTIC Science & Technology

    2012-05-07

    REFERENCES TO THIS STUDY SHOULD INCLUDE THE FOREGOING STATEMENT. QUOTATION FROM, ABSTRACTION FROM, OR REPRODUCTION OF ALL OR ANY PART OF THIS DOCUMENT...hike’s conclusion. The hike was difficult, yet I completed it with all my gear without “falling out”. Never the less, even though the Marines who...for all Marines, regardless of gender. For work-out specific details, see Appendix A. vii Acknowledgements I would like to thank John

  13. The Commander’s Handbook on the Law of Naval Operations NWP 9 (REV.A)/ FMFM 1-10. Annotated Supplement

    DTIC Science & Technology

    1989-01-01

    respecting the Rights and Duties of Neutral Powers and Persons in Case of War on Land, 18 October 1907 Hague VII Hague Convention No. VII relating to the...their internal waters, archipelagic waters, territorial seas and exclusive economic zones, and on their continental shelves. In the case of artificial... Studies , v.61, 1980). For the ambiguous Soviet views, see Franckx, The U.S.S.R. Position on the Innocent Passage of Warships Through Foreign Territorial

  14. Long-Term Management Strategy for Dredged Material Disposal for Naval Facilities at Pearl Harbor, Hawaii. Phase II - Evaulation of Alternatives

    DTIC Science & Technology

    2000-03-01

    26 Leachate Pathway.................................... 31 Plant Uptake Pathway.................................. 35 Volatization and Odor...Bi13 Appendix C - Surface Runoff Testing............................Cl Appendix D - Leachate Evaluation..............................D1 Appendix E...Oxidized Dredged Material..........................29 Table 7. Mixing Zone Requirement for Runoff Discharges............ 30 Table 8. Leachate Quality

  15. 50 CFR 654.24 - Shrimp/stone crab separation zones.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Shrimp/stone crab separation zones. 654.24... Measures § 654.24 Shrimp/stone crab separation zones. Five zones are established in the management area and... trapping. The zones are as shown in Appendix A, Figure 3, of this part. Although Zone II is entirely within...

  16. 50 CFR 654.24 - Shrimp/stone crab separation zones.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Shrimp/stone crab separation zones. 654... Measures § 654.24 Shrimp/stone crab separation zones. Five zones are established in the management area and... trapping. The zones are as shown in Appendix A, Figure 3, of this part. Although Zone II is entirely within...

  17. 32 CFR Appendix D to Part 110 - Application of Advanced Course Formula (Male and Female Members) (Sample)

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Application of Advanced Course Formula (Male and Female Members) (Sample) D Appendix D to Part 110 National Defense Department of Defense OFFICE OF THE... Appendix D to Part 110—Application of Advanced Course Formula (Male and Female Members) (Sample) Zone I...

  18. 32 CFR Appendix D to Part 110 - Application of Advanced Course Formula (Male and Female Members) (Sample)

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Female Members) (Sample) D Appendix D to Part 110 National Defense Department of Defense OFFICE OF THE... COMMUTATION INSTEAD OF UNIFORMS FOR MEMBERS OF THE SENIOR RESERVE OFFICERS' TRAINING CORPS Pt. 110, App. D Appendix D to Part 110—Application of Advanced Course Formula (Male and Female Members) (Sample) Zone I...

  19. 33 CFR 148.707 - What type of criteria will be used in an environmental review and how will they be applied?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Archaeological, cultural and historic sites; (v) Water and air; (vi) Coastal zone management; (vii) Coastal... human health and welfare, including socioeconomic impacts, environmental justice and protection of...

  20. 33 CFR 148.707 - What type of criteria will be used in an environmental review and how will they be applied?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) Archaeological, cultural and historic sites; (v) Water and air; (vi) Coastal zone management; (vii) Coastal... human health and welfare, including socioeconomic impacts, environmental justice and protection of...

  1. 33 CFR 148.707 - What type of criteria will be used in an environmental review and how will they be applied?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) Archaeological, cultural and historic sites; (v) Water and air; (vi) Coastal zone management; (vii) Coastal... human health and welfare, including socioeconomic impacts, environmental justice and protection of...

  2. 33 CFR 148.707 - What type of criteria will be used in an environmental review and how will they be applied?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) Archaeological, cultural and historic sites; (v) Water and air; (vi) Coastal zone management; (vii) Coastal... human health and welfare, including socioeconomic impacts, environmental justice and protection of...

  3. 33 CFR 148.707 - What type of criteria will be used in an environmental review and how will they be applied?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) Archaeological, cultural and historic sites; (v) Water and air; (vi) Coastal zone management; (vii) Coastal... human health and welfare, including socioeconomic impacts, environmental justice and protection of...

  4. 15 CFR Appendix F to Subpart M of... - Davidson Seamount Management Zone

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT NATIONAL MARINE SANCTUARY PROGRAM REGULATIONS Monterey Bay National Marine... [Coordinates in this appendix are unprojected (Geographic Coordinate System) and are calculated using the North...

  5. 15 CFR Appendix F to Subpart M of... - Davidson Seamount Management Zone

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT NATIONAL MARINE SANCTUARY PROGRAM REGULATIONS Monterey Bay National Marine... [Coordinates in this appendix are unprojected (Geographic Coordinate System) and are calculated using the North...

  6. 15 CFR Appendix F to Subpart M of... - Davidson Seamount Management Zone

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT NATIONAL MARINE SANCTUARY PROGRAM REGULATIONS Monterey Bay National Marine... [Coordinates in this appendix are unprojected (Geographic Coordinate System) and are calculated using the North...

  7. 32 CFR Appendix A to Part 110 - Climatic Zones Used To Determine Rates of Commutation Allowance

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Virginia 42. Wisconsin 43. Wyoming The climate zones listed above are to be used as a guide to determine... commanders may request a zone change by submitting evidence to the Major Command of the appropriate Military...

  8. 32 CFR Appendix A to Part 110 - Climatic Zones Used To Determine Rates of Commutation Allowance

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Virginia 42. Wisconsin 43. Wyoming The climate zones listed above are to be used as a guide to determine... commanders may request a zone change by submitting evidence to the Major Command of the appropriate Military...

  9. 32 CFR Appendix A to Part 110 - Climatic Zones Used To Determine Rates of Commutation Allowance

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Virginia 42. Wisconsin 43. Wyoming The climate zones listed above are to be used as a guide to determine... commanders may request a zone change by submitting evidence to the Major Command of the appropriate Military...

  10. 32 CFR Appendix A to Part 110 - Climatic Zones Used To Determine Rates of Commutation Allowance

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Virginia 42. Wisconsin 43. Wyoming The climate zones listed above are to be used as a guide to determine... commanders may request a zone change by submitting evidence to the Major Command of the appropriate Military...

  11. Multiple-Purpose Project, Osage River Basin, Hundred and Ten Mile Creek Kansas, Pomona Lake, Operation and Maintenance Manual. Appendix VII. Construction Foundation Report. Revision.

    DTIC Science & Technology

    1983-10-01

    Rock, from required excavation, was utilized in the embankment. Amonium nitrate and 60 percent dynamite were used. No blasting records were kept...AD A135 578 MULTPLE-PURPOSE PROJECT OSAGE RIVER BASIN HUNDRED AND 1;TEN MILE CREEK KAA U) CORPS OF ENGINEERS KANSASOASS DS C C ES C IT UNCLASIFE D ...ADDRESS 12. REPORT DATE Estimates & Specifications Section (MRKED-DE), 1977 Revised October 1983 Design Branch (MRKED- D ), Kansas City District, 13

  12. 49 CFR Appendix A to Part 222 - Approved Supplementary Safety Measures

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... crossings located within New Partial Quiet Zones shall be closed from 10 p.m. until 7 a.m. every day. Public... apply only to New Quiet Zones or New Partial Quiet Zones. Constant warning time devices and power-out...-Rule Partial Quiet Zones are renewed, or new automatic warning device systems are installed, power-out...

  13. 40 CFR Appendix E to Part 122 - Rainfall Zones of the United States

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Appendix E to Part 122 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS EPA ADMINISTERED PERMIT PROGRAMS: THE NATIONAL POLLUTANT DISCHARGE ELIMINATION SYSTEM Pt. 122, App. E... Protection Agency, Office of Water, Nonpoint Source Division, Washington, DC, 1986. [55 FR 48073, Nov. 16...

  14. 40 CFR Appendix E to Part 122 - Rainfall Zones of the United States

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Appendix E to Part 122 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS EPA ADMINISTERED PERMIT PROGRAMS: THE NATIONAL POLLUTANT DISCHARGE ELIMINATION SYSTEM Pt. 122, App. E... Protection Agency, Office of Water, Nonpoint Source Division, Washington, DC, 1986. [55 FR 48073, Nov. 16...

  15. Technetium and iodine aqueous species immobilization and transformations in the presence of strong reductants and calcite-forming solutions: Remedial action implications

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lawter, Amanda R.; Garcia, Whitney L.; Kukkadapu, Ravi K.

    At the Hanford Site in southeastern Washington State, radionuclide (Tc-99/I-129) laden liquid wastes have been discharged to ground, resulting in vadose zone contamination, which provides a continuous source of these contaminants to groundwater. The presence of multiple contaminants increases the complexity of finding viable remediation technologies to sequester vadose zone contaminants in situ and protect groundwater. Although previous studies have shown the efficiency of zero valent iron (ZVI) and sulfur modified iron (SMI) in reducing mobile Tc(VII) to immobile Tc(IV) and iodate incorporation into calcite, the coupled effects from simultaneously using these remedial technologies have not been previously studied. Inmore » this first-of-a-kind laboratory study, we used two efficient reductants (i.e., ZVI and SMI) and calcite-forming solutions to simultaneously remove aqueous Tc(VII) and iodate via reduction and incorporation, respectively. The results confirmed that Tc(VII) was rapidly removed from the aqueous phase via reduction to Tc(IV). ZVI removed Tc(VII) faster than SMI, although both had removed the same amount by the end of the experiments. Most of the aqueous iodate was rapidly transformed to iodide, and therefore was not incorporated into calcite, but instead remained in the aqueous phase. The iodate reduction to iodide was much faster than iodate incorporation into calcite, suggesting that this remedial pathway is not efficient in removing aqueous iodate when strong reductants are present. Other experiments suggested that iodate removal via calcite precipitation should occur first and then reductants should be added for Tc(VII) removal. Although ZVI can negatively impact microbial populations and thereby inhibit natural attenuation mechanisms, only changes in the makeup of the microbial community were observed. However, these changes in the microbial community may have an impact on remediation efforts in the long term that could not be seen in a short-term study. The results underscore the importance of identifying interactions between natural attenuation pathways and remediation technologies that only target individual contaminants.« less

  16. Reputation-Based Trust for a Cooperative, Agent-Based Backup Protection Scheme for Power Networks

    DTIC Science & Technology

    2010-03-01

    85 Appendix B . Performance Charts for Data by Scenario...protection for that line. For example Relay 3 provides zone 1 coverage for line B and zone 3 coverage for line C. Relay 4 would also provide zone 1...coverage for line B but zone 3 coverage for line A instead since it is directional. Relay 1 and relay 6 would provide zone 3 coverage for line B . A

  17. 15 CFR Appendix C to Subpart H of... - No-Anchoring Seagrass Protection Zones in Tomales Bay

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... to Commerce and Foreign Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT NATIONAL MARINE SANCTUARY PROGRAM REGULATIONS Gulf of the Farallones National Marine Sanctuary Pt. 922, Subpt. H, App. C Appendix C to Subpart H of Part...

  18. Appendix C: GLEES Macroinvertebrates

    Treesearch

    B. C. Kondratieff

    1994-01-01

    This Appendix identifies macroinvertebrate species found in streams and lakes at GLEES during a preliminary qualitative survey conducted in the summer of 1988 by Dr. Boris Kondratieff. The littoral zones of each lake and each stream were sampled by hand-picking and with a triangle net. Insect voucher specimens are maintained in the Gillette Entomological Museum at...

  19. 77 FR 21397 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-10

    ... electrical circuit in the Right Hand (RH) wing must be modified in order to ensure better segregation between... RH wing pylon area to the generator wire bundle of engine 2. The modification of this zone was... authority of the FAA Administrator. ``Subtitle VII: Aviation Programs,'' describes in more detail the scope...

  20. Closing the Chasm: Preparing and Building Post-Conflict Civil Capacity

    DTIC Science & Technology

    2010-03-18

    vii Background and Analysis ...CLOSING THE CHASM: PREPARING AND BUILDING POST-CONFLICT CIVIL CAPACITY Background and Analysis Introduction Plans fail for lack of counsel... rhythmic comfort zone. The lack of Human Resource depth in the military and other Federal agencies‘ directly impact their priorities of ongoing

  1. Damage to urban buildings in zones of intensities VIII and VII during the Wenchuan earthquake and discussion on some typical damages

    NASA Astrophysics Data System (ADS)

    Sun, Jingjiang; Tang, Yuhong; Zheng, Chao; Shi, Hongbin; Lin, Lin; Sun, Zhongxian

    2009-04-01

    The outline and typical characteristics of damages to building in Jiangyou city and Anxian county (intensity VIII), Mianyang city and Deyang city (intensity VII) are introduced in the paper. The damage ratios, based on the sample statistics of multi-story brick buildings together with multi-story brick buildings with RC frame at first story (BBF), are presented. Then some typical damages, such as horizontal cricks of brick masonry buildings, X-shaped cricks on the walls under windows, the damages to columns, beams and infill walls of frame buildings and the damage to half circle-shaped masonry walls, are discussed.

  2. 40 CFR Appendix I to Subpart B of... - Appendix I to Subpart B of Part 205

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...: Acceleration Test: Deceleration Test: Acceleration Test Run No. 1 2 3 4 5 dBA Left Right Highest RPM attained in End Zone Calculated Sound Pressure dBA Deceleration Test with Exhaust Brake Applied dBA Left Right Calculated Sound Pressure dBA TEST Personnel: (Name) Recorded By: Date:......... (Signature) Supervisor...

  3. 40 CFR Appendix I to Subpart B of... - Appendix I to Subpart B of Part 205

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...: Acceleration Test: Deceleration Test: Acceleration Test Run No. 1 2 3 4 5 dBA Left Right Highest RPM attained in End Zone Calculated Sound Pressure dBA Deceleration Test with Exhaust Brake Applied dBA Left Right Calculated Sound Pressure dBA TEST Personnel: (Name) Recorded By: Date:......... (Signature) Supervisor...

  4. 49 CFR Appendix A to Part 194 - Guidelines for the Preparation of Response Plans

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Oil spill removal organization field equipment deployment drills conducted yearly. (5) A drill that... PLANS FOR ONSHORE OIL PIPELINES Pt. 194, App. A Appendix A to Part 194—Guidelines for the Preparation of... substantial harm to the environment; (4) A list of line sections contained in the response zone, identified by...

  5. 49 CFR Appendix A to Part 194 - Guidelines for the Preparation of Response Plans

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) Oil spill removal organization field equipment deployment drills conducted yearly. (5) A drill that... PLANS FOR ONSHORE OIL PIPELINES Pt. 194, App. A Appendix A to Part 194—Guidelines for the Preparation of... substantial harm to the environment; (4) A list of line sections contained in the response zone, identified by...

  6. 49 CFR Appendix A to Part 194 - Guidelines for the Preparation of Response Plans

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) Oil spill removal organization field equipment deployment drills conducted yearly. (5) A drill that... PLANS FOR ONSHORE OIL PIPELINES Pt. 194, App. A Appendix A to Part 194—Guidelines for the Preparation of... substantial harm to the environment; (4) A list of line sections contained in the response zone, identified by...

  7. 49 CFR Appendix A to Part 194 - Guidelines for the Preparation of Response Plans

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) Oil spill removal organization field equipment deployment drills conducted yearly. (5) A drill that... PLANS FOR ONSHORE OIL PIPELINES Pt. 194, App. A Appendix A to Part 194—Guidelines for the Preparation of... substantial harm to the environment; (4) A list of line sections contained in the response zone, identified by...

  8. 49 CFR Appendix A to Part 194 - Guidelines for the Preparation of Response Plans

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) Oil spill removal organization field equipment deployment drills conducted yearly. (5) A drill that... PLANS FOR ONSHORE OIL PIPELINES Pt. 194, App. A Appendix A to Part 194—Guidelines for the Preparation of... substantial harm to the environment; (4) A list of line sections contained in the response zone, identified by...

  9. 33 CFR 155.5035 - Nontank vessel response plan requirements: Specific content.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-hour basis; (3) A list of the Captain of the Port (COTP) zones, ports, and offshore transit areas in... areas and information for key components within each functional area— (i) Command and control; (ii...; (vi) Planning; (vii) Logistics support; and (viii) Finance; and (5) The responsibilities and duties of...

  10. The Revalidation of an Instrument to Measure Zones of Indifference of Teachers to Directives Issued by Administrators.

    ERIC Educational Resources Information Center

    Wilkes, Sam T.; Blackbourn, Joe M.

    This project attempts to refine the Zones of Indifference Instrument, (included in appendix) that measures zones of indifference of teachers to typical directives issued by administrators. As a result of the original validation study, a 78-item, two-factor instrument was developed. These two factors explained 52 percent of the variance. The…

  11. 14 CFR Appendix A to Part 151 - Appendix A to Part 151

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... zones at ends of eligible runways. (d) Approach lights (land for ALS eligible for 75 percent participation will be limited to an area 3200′ × 400′ for a Standard ALS and to an area 1700′ × 400′ for a short ALS located symmetrically about the runway centerline extended, beginning at the end of the runway...

  12. 14 CFR Appendix A to Part 151 - Appendix A to Part 151

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... zones at ends of eligible runways. (d) Approach lights (land for ALS eligible for 75 percent participation will be limited to an area 3200′ × 400′ for a Standard ALS and to an area 1700′ × 400′ for a short ALS located symmetrically about the runway centerline extended, beginning at the end of the runway...

  13. 14 CFR Appendix A to Part 151 - Appendix A to Part 151

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... zones at ends of eligible runways. (d) Approach lights (land for ALS eligible for 75 percent participation will be limited to an area 3200′ × 400′ for a Standard ALS and to an area 1700′ × 400′ for a short ALS located symmetrically about the runway centerline extended, beginning at the end of the runway...

  14. 14 CFR Appendix A to Part 151 - Appendix A to Part 151

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... zones at ends of eligible runways. (d) Approach lights (land for ALS eligible for 75 percent participation will be limited to an area 3200′ × 400′ for a Standard ALS and to an area 1700′ × 400′ for a short ALS located symmetrically about the runway centerline extended, beginning at the end of the runway...

  15. 14 CFR Appendix A to Part 151 - Appendix A to Part 151

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... zones at ends of eligible runways. (d) Approach lights (land for ALS eligible for 75 percent participation will be limited to an area 3200′ × 400′ for a Standard ALS and to an area 1700′ × 400′ for a short ALS located symmetrically about the runway centerline extended, beginning at the end of the runway...

  16. 40 CFR Appendix E to Part 63 - Monitoring Procedure for Nonthoroughly Mixed Open Biological Treatment Systems at Kraft Pulp...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... for each data set that is collected during the initial performance test. A single composite value of... Multiple Zone Concentrations Calculations Procedure based on inlet and outlet concentrations (Column A of... composite value of Ks discussed in section III.C of this appendix. This value of Ks is calculated during the...

  17. Photometric and spectral evolution of the symbiotic eclipsing variable V1329 Cygni at a late stage of its nova-like outburst

    NASA Astrophysics Data System (ADS)

    Arkhipova, V. P.; Esipov, V. F.; Ikonnikova, N. P.; Komissarova, G. V.

    2015-03-01

    The photoelectric UBV observations of the peculiar symbiotic star V1329 Cyg performed at the Crimean Station of the SAI-MSU during 245 nights over the period 2003-2014 are presented. The star's light curves since 1973 from the Crimean observations are shown. The brightness decline after its outburst over the last 40 years was . The phase color curves at phases 0.2 and 0.8 have maxima. Their qualitative interpretation in terms of the model of interacting winds in symbiotic binary star systems is proposed. The orbital period of the binary system has been redetermined. The spectroscopic observations at the 125-cm telescope of the Crimean Station from 1994 to 2014 have confirmed the change in the system's emission spectrum with orbital phase. The HI, He I, and Fe II line fluxes clearly trace the orbital motion. The Balmer hydrogen lines as well as the continuum at λ6000 and the V-band flux change by a factor of ˜3.5 from minimum to maximum light. The neutral helium lines change by a factor of 5. The high-excitation He II, [FeVII], [Ca VII] lines and the Raman O VI λ6825 line have shown changes in the fluxes by a factor of ˜2-3 weakly correlating with the orbital phase. The equivalent widths of the HI and He I lines are maximal at the star's maximum light and have distinct minima at phases 0.2 and 0.8, while the equivalent widths of the He II, [FeVII], and [CaVII] lines are minimal in the range of phases 0.2-0.8. The question about the location of the permitted and forbidden line emission zones in the binary system V1329 Cyg is discussed. The evolution of the emission spectrum for V1329 Cyg from 1980 to 2014 has been studied on the basis of new and archival data. A gradual decrease in the absolute fluxes of the nebular emission lines has been detected. The [O III] and [Fe VII] lines have weakened significantly. However, the [Fe X] λ6375 Å line has appeared and gradually strengthened, suggesting an increase in the degree of gas ionization in the line formation zone.

  18. 15 CFR Appendix E to Subpart M of... - Motorized Personal Watercraft Zones and Access Routes Within the Sanctuary

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... access route southwest along a bearing of approximately 196° true (180° magnetic) to the red and white...° magnetic) to the red and white bell buoy at the eastern boundary of Zone Three bounded by: Point ID No...° true (0° magnetic) to the southern boundary of Zone Four bounded by: Point ID No. Latitude Longitude 1...

  19. 47 CFR 101.113 - Transmitter power limitations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... of harmful interference, the Commission may, after notice and opportunity for hearing, order a change... frequency band. (ii) The climate zones in Table 1 are defined for different geographic locations within the US as shown in Appendix 28 of the ITU Radio Regulations. Table 1 1 Climate zone e.i.r.p. Spectral...

  20. 47 CFR 101.113 - Transmitter power limitations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... of harmful interference, the Commission may, after notice and opportunity for hearing, order a change... frequency band. (ii) The climate zones in Table 1 are defined for different geographic locations within the US as shown in Appendix 28 of the ITU Radio Regulations. Table 1 1 Climate zone e.i.r.p. Spectral...

  1. 47 CFR 101.113 - Transmitter power limitations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... of harmful interference, the Commission may, after notice and opportunity for hearing, order a change... frequency band. (ii) The climate zones in Table 1 are defined for different geographic locations within the US as shown in Appendix 28 of the ITU Radio Regulations. Table 1 1 Climate zone e.i.r.p. Spectral...

  2. 47 CFR 101.113 - Transmitter power limitations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of harmful interference, the Commission may, after notice and opportunity for hearing, order a change... frequency band. (ii) The climate zones in Table 1 are defined for different geographic locations within the US as shown in Appendix 28 of the ITU Radio Regulations. Table 1 1 Climate zone e.i.r.p. Spectral...

  3. Two-incision laparoscopic appendectomy for a severe hemophilia A child patient with coagulation factor VII deficiency: Case report and review of literature.

    PubMed

    He, Jin Peng; Feng, Jie Xiong

    2017-10-01

    The main complication of patients with severe hemophilia is recurrent bleeding events that usually affected musculoskeletal contractures. And replacement therapy methods were continuously improved to minimize adverse impacts brought by those complications. However, only several cases reported about the appendectomy for hemophilia A. We report a case of acute appendicitis treated by two-incision laparoscopy in a boy with hemophilia A and coagulation factor VII deficiency for the first time. An 8y7m-old Chinese boy presented with half a day of right sided abdominal pain, fever, nausea, and vomiting. He received a computed tomography (CT) scan which revealed an enlarged appendix, thickened wall and appendiceal fecalith, and had received a conservative anti-bacterial treatment for his acute appendicitis but failed. He was diagnosed with hemophilia A and coagulation factor VII deficiency. Two-incision laparoscopic appendectomy was made in success with a careful management of perioperative period. We monitored the clotting factor FVIII level and gave him a replacement therapy. The patient had an uneventful recovery. It is important to exclude intraabdominal or retroperitoneal hemorrhage in patients suffering from hemophilia and acute abdominal pain. Pre-operative evaluation of validity of the FVIII replacement therapy is another effective strategy to assess the safety and feasibility of applying an operation procedure. The two-incision laparoscopic appendectomy is an effective treatment for this kind of patients for its minimal trauma and fast recovery characteristics. Our report shows that laparoscopic appendectomy is feasible in a child suffering from hemophilia after adequate blood clotting factor replacement treatment.

  4. MITHRAS: A Program of Simultaneous Radar Observations of the High-Latitude Auroral Zone.

    DTIC Science & Technology

    1982-11-01

    Latitude * and Time for Chatanika ..... ................. ... 38 111-5 Cross Polar Cap Potential Versus Solar-Wind Energy Parameter...49 vii 9 III-10 Scatter Plot of Pedersen Conductivities as a Function of Average Energy for Two Levels of Total...Precipitated Energy ....... ....... ......... .. 51 -IIl-1 For Initial Time and Steady State, (a) Latitudinal Profile of the Meridional Electric-Field

  5. 40 CFR Appendix E to Part 63 - Monitoring Procedure for Nonthoroughly Mixed Open Biological Treatment Systems at Kraft Pulp...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... II. Definitions Biological treatment unit = wastewater treatment unit designed and operated to... last zone in the series and ending with the first zone. B. Data Collection Requirements This method is based upon modeling the nonthoroughly mixed open biological treatment unit as a series of well-mixed...

  6. 40 CFR Appendix E to Part 300 - Oil Spill Response

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., other waters of the high seas subject to the NCP, and the land surface or land substrata, ground waters... response equipment; and a district response advisory team. Contiguous zone means the zone of the high seas... of the discharge. 2.2Priorities. (a) Safety of human life must be given the highest priority during...

  7. Marine biology

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Thurman, H.V.; Webber, H.H.

    1984-01-01

    This book discusses both taxonomic and ecological topics on marine biology. Full coverage of marine organisms of all five kingdoms is provided, along with interesting and thorough discussion of all major marine habitats. Organization into six major parts allows flexibility. It also provides insight into important topics such as disposal of nuclear waste at sea, the idea that life began on the ocean floor, and how whales, krill, and people interact. A full-color photo chapter reviews questions, and exercises. The contents are: an overview marine biology: fundamental concepts/investigating life in the ocean; the physical ocean, the ocean floor, the naturemore » of water, the nature and motion of ocean water; general ecology, conditions for life in the sea, biological productivity and energy transfer; marine organisms; monera, protista, mycota and metaphyta; the smaller marine animals, the large animals marine habitats, the intertidal zone/benthos of the continental shelf, the photic zone, the deep ocean, the ocean under stress, marine pollution, appendix a: the metric system and conversion factors/ appendix b: prefixes and suffixes/ appendix c: taxonomic classification of common marine organisms, and glossary, and index.« less

  8. Standard for Ground Vehicle Mobility

    DTIC Science & Technology

    2005-02-01

    Zone Dry climates (2), humid mesothermal (3), See Appendix A humid microthermal (4), undifferentiated highland (6) Condition Dry, wet, snow See...represent the Dry, the Humid Mesothermal, and the Humid Microthermal climate zones, respectively. Scenarios ERDC-GSL was sponsored by WARSIM to...Coast D. Humid Microthermal Climates Humid Continental, Warm Summer, Humid Continental, Cool Summer, Sub-Arctic E. Polar Climates Tundra, Ice Caps F

  9. MX Siting Investigation Gravity Survey - Wah Wah Valley, Utah.

    DTIC Science & Technology

    1981-05-15

    Bouguer Anomaly (see Section A1.4, Appendix A1.0). The Defense Mapping Agency Aerospace Center (DMAAC), St. Louis, Missouri, calculates outer zone...Utah .... 12 LIST OF DRAWINGS Drawing Number 1 Complete Bouguer Anomaly Contours In Pocket at 2 Deptn to Rock - Interpreted from End of Report...DMAHTC/GSS obtained the basic observations for the new stations and reduced them to Simple Bouguer Anomalies (SBA) as described in Appendix A1.0. Up to

  10. Two-incision laparoscopic appendectomy for a severe hemophilia A child patient with coagulation factor VII deficiency

    PubMed Central

    He, Jin Peng; Feng, Jie Xiong

    2017-01-01

    Abstract Rationale: The main complication of patients with severe hemophilia is recurrent bleeding events that usually affected musculoskeletal contractures. And replacement therapy methods were continuously improved to minimize adverse impacts brought by those complications. However, only several cases reported about the appendectomy for hemophilia A. We report a case of acute appendicitis treated by two-incision laparoscopy in a boy with hemophilia A and coagulation factor VII deficiency for the first time. Patient concerns: An 8y7m-old Chinese boy presented with half a day of right sided abdominal pain, fever, nausea, and vomiting. Diagnoses: He received a computed tomography (CT) scan which revealed an enlarged appendix, thickened wall and appendiceal fecalith, and had received a conservative anti-bacterial treatment for his acute appendicitis but failed. He was diagnosed with hemophilia A and coagulation factor VII deficiency. Interventions: Two-incision laparoscopic appendectomy was made in success with a careful management of perioperative period. We monitored the clotting factor FVIII level and gave him a replacement therapy. Outcomes: The patient had an uneventful recovery. Lessons: It is important to exclude intraabdominal or retroperitoneal hemorrhage in patients suffering from hemophilia and acute abdominal pain. Pre-operative evaluation of validity of the FVIII replacement therapy is another effective strategy to assess the safety and feasibility of applying an operation procedure. The two-incision laparoscopic appendectomy is an effective treatment for this kind of patients for its minimal trauma and fast recovery characteristics. Our report shows that laparoscopic appendectomy is feasible in a child suffering from hemophilia after adequate blood clotting factor replacement treatment. PMID:29019885

  11. The Utility and Consequences of Using Impressed Child Soldiers in Africa’s Contemporary Wars

    DTIC Science & Technology

    2000-04-01

    AU/ACSC/090/2000-04 AIR COMMAND AND STAFF COLLEGE AIR UNIVERSITY THE UTILITY AND CONSEQUENCES OF USING IMPRESSED CHILD SOLDIERS IN AFRICA’S...4. TITLE AND SUBTITLE The Utility and Consequences of Using Impressed Child Soldiers in Africa’s Contemporary Wars 5a. CONTRACT NUMBER 5b...VII THE NEW ERA OF THE CHILD SOLDIERS IN AFRICA’S COMBAT ZONES.......................1

  12. Guidelines and Data to Support Plans for Reallocating Food during Crisis Relocation. Regional Appendix. FEMA Region VII,

    DTIC Science & Technology

    1982-09-01

    using approximation techniques developed in earlier SYSTAN work (Food Systn.em Suport of the Rclocntion Strategy, September, 1975). Using this technique...INC VOONE IA 1 0 0 0 1 0 5,000 SUFER VALU STORES INC DES MOINES IA I 0 0 1 0 0 3,000 COUNTY TOTAL: 3 1 0 1 1 0 3,750 M;,HASKA FARE!AY STORES INC SOCNE...5,000 SUFER VALU SCPES INC DES tFOINES IA 1 0 0 1 0 0 3,000 U’lITED A G SIORES OMAHA NE 3 3 0 0 0 0 2,250 COUNTY TOTAL: 6 3 0 1 2 0 15,250 SI[’UX

  13. A history of the treatment of appendicitis in children: lessons learned.

    PubMed

    Hamill, James K; Hill, Andrew G

    2016-10-01

    During the latter half of the 19th century, surgeons increasingly reported performing appendicectomies. Fitz from Harvard, Groves from Canada and Tait from Britain all recorded successful removal of the appendix. McBurney described the point of maximal tenderness in classic appendicitis and also the muscle-splitting incision centred on this point. Priority is given to McArthur in describing the lateral muscle-splitting incision. The direction of the cutaneous incision was later modified by Elliott and Lanz. Incisions that healed well were essential to recovery. Appendicectomy became a 'fashionable' operation after the London surgeon, Treves, removed the appendix of King Edward VII. Through the 20th century, the mortality from appendicitis fell notably with the advent of sulphonamide and penicillin, improvements in fluid therapy and safer anaesthesia. By 1990, diagnostic delay was the main cause of death. Semm performed the first laparoscopic appendicectomy in 1990, roundly criticized at the time for what is now a routine procedure. We view contemporary debates on the indications for appendicectomy, the best approach and how to optimize recovery in the light of the history of this intriguing disease. © 2016 Royal Australasian College of Surgeons.

  14. Critical Evaluation of State-of-the-Art In Situ Thermal Treatment Technologies for DNAPL Source Zone Treatment

    DTIC Science & Technology

    2010-01-01

    from steel pipe , copper plate for heating distinct zones and sheet pile. Sheet pile electrodes allow for quick installation with little to no drilling...as electrodes. Electrodes constructed using Thermal Remediation Services - Electrical Resistance Heating ER-0314 18 Appendix B steel pipe are...who authored state- of-the-art descriptions for the most common in-situ thermal technologies currently employed:  Electrical Resistance Heating

  15. QCD as a Theory of Hadrons

    NASA Astrophysics Data System (ADS)

    Narison, Stephan

    2004-05-01

    About Stephan Narison; Outline of the book; Preface; Acknowledgements; Part I. General Introduction: 1. A short flash on particle physics; 2. The pre-QCD era; 3. The QCD story; 4. Field theory ingredients; Part II. QCD Gauge Theory: 5. Lagrangian and gauge invariance; 6. Quantization using path integral; 7. QCD and its global invariance; Part III. MS scheme for QCD and QED: Introduction; 8. Dimensional regularization; 9. The MS renormalization scheme; 10. Renormalization of operators using the background field method; 11. The renormalization group; 12. Other renormalization schemes; 13. MS scheme for QED; 14. High-precision low-energy QED tests; Part IV. Deep Inelastic Scattering at Hadron Colliders: 15. OPE for deep inelastic scattering; 16. Unpolarized lepton-hadron scattering; 17. The Altarelli-Parisi equation; 18. More on unpolarized deep inelastic scatterings; 19. Polarized deep-inelastic processes; 20. Drell-Yan process; 21. One 'prompt photon' inclusive production; Part V. Hard Processes in e+e- Collisions: Introduction; 22. One hadron inclusive production; 23. gg scatterings and the 'spin' of the photon; 24. QCD jets; 25. Total inclusive hadron productions; Part VI. Summary of QCD Tests and as Measurements; Part VII. Power Corrections in QCD: 26. Introduction; 27. The SVZ expansion; 28. Technologies for evaluating Wilson coefficients; 29. Renormalons; 30. Beyond the SVZ expansion; Part VIII. QCD Two-Point Functions: 31. References guide to original works; 32. (Pseudo)scalar correlators; 33. (Axial-)vector two-point functions; 34. Tensor-quark correlator; 35. Baryonic correlators; 36. Four-quark correlators; 37. Gluonia correlators; 38. Hybrid correlators; 39. Correlators in x-space; Part IX. QCD Non-Perturbative Methods: 40. Introduction; 41. Lattice gauge theory; 42. Chiral perturbation theory; 43. Models of the QCD effective action; 44. Heavy quark effective theory; 45. Potential approaches to quarkonia; 46. On monopole and confinement; Part X. QCD Spectral Sum Rules: 47. Introduction; 48. Theoretical foundations; 49. Survey of QCD spectral sum rules; 50. Weinberg and DMO sum rules; 51. The QCD coupling as; 52. The QCD condensates; 53. Light and heavy quark masses, etc.; 54. Hadron spectroscopy; 55. D, B and Bc exclusive weak decays; 56. B0(s)-B0(s) mixing, kaon CP violation; 57. Thermal behaviour of QCD; 58. More on spectral sum rules; Part XI. Appendix A: physical constants and unites; Appendix B: weight factors for SU(N)c; Appendix C: coordinates and momenta; Appendix D: Dirac equation and matrices; Appendix E: Feynman rules; Appendix F: Feynman integrals; Appendix G: useful formulae for the sum rules; Bibliography; Index.

  16. QCD as a Theory of Hadrons

    NASA Astrophysics Data System (ADS)

    Narison, Stephan

    2007-07-01

    About Stephan Narison; Outline of the book; Preface; Acknowledgements; Part I. General Introduction: 1. A short flash on particle physics; 2. The pre-QCD era; 3. The QCD story; 4. Field theory ingredients; Part II. QCD Gauge Theory: 5. Lagrangian and gauge invariance; 6. Quantization using path integral; 7. QCD and its global invariance; Part III. MS scheme for QCD and QED: Introduction; 8. Dimensional regularization; 9. The MS renormalization scheme; 10. Renormalization of operators using the background field method; 11. The renormalization group; 12. Other renormalization schemes; 13. MS scheme for QED; 14. High-precision low-energy QED tests; Part IV. Deep Inelastic Scattering at Hadron Colliders: 15. OPE for deep inelastic scattering; 16. Unpolarized lepton-hadron scattering; 17. The Altarelli-Parisi equation; 18. More on unpolarized deep inelastic scatterings; 19. Polarized deep-inelastic processes; 20. Drell-Yan process; 21. One 'prompt photon' inclusive production; Part V. Hard Processes in e+e- Collisions: Introduction; 22. One hadron inclusive production; 23. gg scatterings and the 'spin' of the photon; 24. QCD jets; 25. Total inclusive hadron productions; Part VI. Summary of QCD Tests and as Measurements; Part VII. Power Corrections in QCD: 26. Introduction; 27. The SVZ expansion; 28. Technologies for evaluating Wilson coefficients; 29. Renormalons; 30. Beyond the SVZ expansion; Part VIII. QCD Two-Point Functions: 31. References guide to original works; 32. (Pseudo)scalar correlators; 33. (Axial-)vector two-point functions; 34. Tensor-quark correlator; 35. Baryonic correlators; 36. Four-quark correlators; 37. Gluonia correlators; 38. Hybrid correlators; 39. Correlators in x-space; Part IX. QCD Non-Perturbative Methods: 40. Introduction; 41. Lattice gauge theory; 42. Chiral perturbation theory; 43. Models of the QCD effective action; 44. Heavy quark effective theory; 45. Potential approaches to quarkonia; 46. On monopole and confinement; Part X. QCD Spectral Sum Rules: 47. Introduction; 48. Theoretical foundations; 49. Survey of QCD spectral sum rules; 50. Weinberg and DMO sum rules; 51. The QCD coupling as; 52. The QCD condensates; 53. Light and heavy quark masses, etc.; 54. Hadron spectroscopy; 55. D, B and Bc exclusive weak decays; 56. B0(s)-B0(s) mixing, kaon CP violation; 57. Thermal behaviour of QCD; 58. More on spectral sum rules; Part XI. Appendix A: physical constants and unites; Appendix B: weight factors for SU(N)c; Appendix C: coordinates and momenta; Appendix D: Dirac equation and matrices; Appendix E: Feynman rules; Appendix F: Feynman integrals; Appendix G: useful formulae for the sum rules; Bibliography; Index.

  17. Technetium and iodine aqueous species immobilization and transformations in the presence of strong reductants and calcite-forming solutions: Remedial action implications.

    PubMed

    Lawter, Amanda R; Garcia, Whitney L; Kukkadapu, Ravi K; Qafoku, Odeta; Bowden, Mark E; Saslow, Sarah A; Qafoku, Nikolla P

    2018-04-30

    At the Hanford Site in southeastern Washington, discharge of radionuclide laden liquid wastes resulted in vadose zone contamination, providing a continuous source of these contaminants to groundwater. The presence of multiple contaminants (i.e., 99 Tc and 129 I) increases the complexity of finding viable remediation technologies to sequester contaminants in situ and protect groundwater. Although previous studies have shown the efficiency of zero valent iron (ZVI) and sulfur modified iron (SMI) in reducing mobile Tc(VII) to immobile Tc(IV) and iodate incorporation into calcite, the coupled effects from simultaneously using these remedial technologies have not been previously studied. In this first-of-a-kind laboratory study, we used reductants (ZVI or SMI) and calcite-forming solutions to simultaneously remove aqueous Tc(VII) and iodate via reduction and incorporation, respectively. The results confirmed that Tc(VII) was rapidly removed from the aqueous phase via reduction to Tc(IV). Most of the aqueous iodate was transformed to iodide faster than incorporation into calcite occurred, and therefore the I remained in the aqueous phase. These results suggested that this remedial pathway is not efficient in immobilizing iodate when reductants are present. Other experiments suggested that iodate removal via calcite precipitation should occur prior to adding reductants for Tc(VII) removal. When microbes were included in the tests, there was no negative impact on the microbial population but changes in the makeup of the microbial community were observed. These microbial community changes may have an impact on remediation efforts in the long-term that could not be seen in a short-term study. The results underscore the importance of identifying interactions between natural attenuation pathways and remediation technologies that only target individual contaminants. Copyright © 2018 Elsevier B.V. All rights reserved.

  18. Immunomodulatory activity of various fractions derived from Physalis angulata L extract.

    PubMed

    Lin, Y S; Chiang, H C; Kan, W S; Hone, E; Shih, S J; Won, M H

    1992-01-01

    The immunomodulatory effects of Physalis angulata L. extract fraction VII (PA-VII), PA-VII-A, PA-VII-B and PA-VII-C were investigated in this study. The results showed that PA-VII and PA-VII-C strongly enhanced blastogenesis response, PA-VII-B had moderate activity, and PA-VII-A exerted only slight effect on cell proliferation. A synergistic effect was observed when the suboptimal dosage of phytohemagglutinin (PHA) or lipopolysaccharide (LPS) was added to the culture. Furthermore, PA-VII and PA-VII-C possessed stimulatory activity on B cells and less effect on T cells. The antibody responses were also augmented by PA-VII, PA-VII-B and PA-VII-C, but not by PA-VII-A. The enhancement of antibody response could be observed both in BALB/c and C3H/HeJ mice.

  19. Increased volume of distribution for recombinant activated factor VII and longer plasma-derived factor VII half-life may explain their long lasting prophylactic effect.

    PubMed

    Mathijssen, Natascha C J; Masereeuw, Rosalinde; Holme, Pal Andre; van Kraaij, Marian G J; Laros-van Gorkom, Britta A P; Peyvandi, Flora; van Heerde, Waander L

    2013-08-01

    Prophylaxis with plasma-derived or recombinant activated factor VII is beneficial in severe factor VII deficiency. To understand why prophylactic treatment with both products is efficacious, we conducted a pharmacokinetic study. Ten factor VII deficient patients were treated with either recombinant activated (20 μg/kg) or plasma-derived (25 IU/kg) factor VII in a cross-over design. Pharmacokinetic parameters were analyzed through activated factor VII activity, factor VII clotting activity, and factor VII antigen levels on depicted time points. Factor VII activity half-lifes, determined by non-compartmental and one-compartmental analysis (results in brackets), were shorter for recombinant activated (1.4h; 0.7h) than for plasma-derived factor VII (6.8h; 3.2h); both recombinant activated (5.1h; 2.1h and plasma-derived factor VII (5.8h; 3.2h) resulted in longer half-lives of factor VII antigen. Activated factor VII half-lives (based on activated factor VII activity levels) were significantly higher compared to factor VII clotting activity (1.6h; 0.9h). Volumes of distribution were significantly higher for activated factor VII (236 ml/kg; 175 ml/kg, measured by activated factor VII) as compared to plasma-derived factor VII (206 ml/kg; 64 ml/kg, measured by factor FVII activity), suggesting a plasma- and extracellular fluid distribution for recombinant activated factor VII. Recombinant activated factor VII showed significantly shorter half-lifes than plasma-derived factor VII. Volumes of distribution were significantly higher for treatment with recombinant activated factor VII. The longer half-life for plasma-derived factor VII, compared to recombinant activated factor VII, and the increased volume of distribution for recombinant activated factor VII, compared to plasma-derived factor VII may further elucidate the beneficial effect of prophylactic treatment of both products. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. Port Needs Study (Vessel Traffic Services Benefits) : Volume 2. Appendices, Part 1.

    DOT National Transportation Integrated Search

    1991-08-01

    Volume II focuses on organization and presentation of information for each individual study zone. It contains the appendix tables of input data, output statistics and the documentation of the candidate Vessel Traffic Service (VTS) Design by NavCom Sy...

  1. Port Needs Study (Vessel Traffic Services Benefits) : Volume 2. Appendices, Part 2.

    DOT National Transportation Integrated Search

    1991-01-01

    Volume II focuses on organization and presentation of information for each individual study zone. It contains the appendix tables of input data, output statistics and the documentation of the candidate Vessel Traffic Services (VTS) Design by NavCom S...

  2. 10 CFR Appendix A to Part 600 - Generally Applicable Requirements

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Zone Management Act of 1972, as amended (16 U.S.C. 1451 et seq.) (15 CFR part 930). Endangered Species...), Power Plant and Industrial Fuel Use Act of 1978, (42 U.S.C. 8373(b)); Executive Order 12185 (December 17...

  3. 10 CFR Appendix A to Part 600 - Generally Applicable Requirements

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Zone Management Act of 1972, as amended (16 U.S.C. 1451 et seq.) (15 CFR part 930). Endangered Species...), Power Plant and Industrial Fuel Use Act of 1978, (42 U.S.C. 8373(b)); Executive Order 12185 (December 17...

  4. 10 CFR Appendix A to Part 600 - Generally Applicable Requirements

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Zone Management Act of 1972, as amended (16 U.S.C. 1451 et seq.) (15 CFR part 930). Endangered Species...), Power Plant and Industrial Fuel Use Act of 1978, (42 U.S.C. 8373(b)); Executive Order 12185 (December 17...

  5. Environmental application of remote sensing methods to coastal zone land use and marine resource management. Appendix F: User's guide for advection, convection prototype. [southeastern Virginia

    NASA Technical Reports Server (NTRS)

    1972-01-01

    A user's manual is provided for the environmental computer model proposed for the Richmond-Cape Henry Environmental Laboratory (RICHEL) application project for coastal zone land use investigations and marine resources management. The model was developed around the hydrologic cycle and includes two data bases consisting of climate and land use variables. The main program is described, along with control parameters to be set and pertinent subroutines.

  6. Western Shallow Oil Zone, Elk Hills Field, Kern County, California: General reservoir study, Appendix 4, Fourth Wilhelm sand

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Carey, K.B.

    1987-09-01

    The general Reservoir Study of the Western Shallow Oil Zone was prepared by Evans, Carey and Crozier as Task Assignment 009 with the United States Department of Energy. This study, Appendix IV, addresses the Fourth Wilhelm Sand and its sub units and pools. Basic pressure, production and assorted technical data were provided by the US Department of Energy staff at Elk Hills. Basic pressure production and assorted technical data were provided by the US Department of Energy staff at Elk Hills. These data were accepted as furnished with no attempt being made by Evans, Carey and Crozier for independent verification.more » This study has identified the petrophysical properties and the past productive performance of the reservoir. Primary reserves have been determined and general means of enhancing future recovery have been suggested. It is hoped that this volume can now additionally serve as a take off point for exploitation engineers to develop specific programs toward the end. 12 figs., 9 tabs.« less

  7. Western Shallow Oil Zone, Elk Hills Field, Kern County, California: General reservoir study, Appendix 3, Second Wilhelm Sand

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Carey, K.B.

    1987-09-01

    The general Reservoir Study of the Western Shallow Oil Zone was prepared by Evans, Carey and Crozier as Task Assignment 009 under Contract No. DE-ACO1-85FE60600 with the United States Department of Energy. This study Appendix III, the second Wilhelm Sand and it's sub units and pools. Basic pressure, production and assorted technical data were provided by the U.S. Department of Energy staff at Elk Hills. These data were accepted as furnished with no attempt being made by Evans, Carey and Crozier for independent verification. This study has identified the petrophysical properties and the past productive performance of the reservoir. Primarymore » reserves have been determined and general means of enhancing future recovery have been suggested. It is hoped that this volume can not additionally serve as a take off point for exploitation engineers to develop specific programs towards these ends. 15 figs., 9 tabs.« less

  8. 32 CFR Appendix B to Part 989 - Categorical Exclusions

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... influence, activity, or effect in areas not already significantly modified from their natural condition. A2... areas of critical environmental concern, such as prime or unique agricultural lands, wetlands, coastal zones, wilderness areas, floodplains, or wild and scenic river areas. A2.2.8. Proposals with...

  9. 32 CFR Appendix B to Part 989 - Categorical Exclusions

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... influence, activity, or effect in areas not already significantly modified from their natural condition. A2... areas of critical environmental concern, such as prime or unique agricultural lands, wetlands, coastal zones, wilderness areas, floodplains, or wild and scenic river areas. A2.2.8. Proposals with...

  10. 32 CFR Appendix B to Part 989 - Categorical Exclusions

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... influence, activity, or effect in areas not already significantly modified from their natural condition. A2... areas of critical environmental concern, such as prime or unique agricultural lands, wetlands, coastal zones, wilderness areas, floodplains, or wild and scenic river areas. A2.2.8. Proposals with...

  11. 32 CFR Appendix B to Part 989 - Categorical Exclusions

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... influence, activity, or effect in areas not already significantly modified from their natural condition. A2... areas of critical environmental concern, such as prime or unique agricultural lands, wetlands, coastal zones, wilderness areas, floodplains, or wild and scenic river areas. A2.2.8. Proposals with...

  12. 32 CFR Appendix B to Part 989 - Categorical Exclusions

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... influence, activity, or effect in areas not already significantly modified from their natural condition. A2... areas of critical environmental concern, such as prime or unique agricultural lands, wetlands, coastal zones, wilderness areas, floodplains, or wild and scenic river areas. A2.2.8. Proposals with...

  13. 15 CFR 922.121 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... MARINE SANCTUARY PROGRAM REGULATIONS Flower Garden Banks National Marine Sanctuary § 922.121 Definitions... stipulations for OCS lease sale 112 over and surrounding the East and West Flower Garden Banks, and the... East and West Flower Garden Banks are provided in appendix B of this subpart; the no-activity zone...

  14. 15 CFR 922.121 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... MARINE SANCTUARY PROGRAM REGULATIONS Flower Garden Banks National Marine Sanctuary § 922.121 Definitions... stipulations for OCS lease sale 112 over and surrounding the East and West Flower Garden Banks, and the... East and West Flower Garden Banks are provided in appendix B of this subpart; the no-activity zone...

  15. 15 CFR 922.121 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... MARINE SANCTUARY PROGRAM REGULATIONS Flower Garden Banks National Marine Sanctuary § 922.121 Definitions... stipulations for OCS lease sale 112 over and surrounding the East and West Flower Garden Banks, and the... East and West Flower Garden Banks are provided in appendix B of this subpart; the no-activity zone...

  16. 44 CFR Appendix B to Part 62 - National Flood Insurance Program

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... quality control departments, or both, and independent Certified Public Accountant (CPA) firms. This Plan... individual State Insurance Departments, NAIC Zone examinations, and independent CPA firms. (c) Standards... company must— (A) Have a biennial audit of the flood insurance financial statements conducted by a CPA...

  17. 44 CFR Appendix B to Part 62 - National Flood Insurance Program

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... quality control departments, or both, and independent Certified Public Accountant (CPA) firms. This Plan... individual State Insurance Departments, NAIC Zone examinations, and independent CPA firms. (c) Standards... company must— (A) Have a biennial audit of the flood insurance financial statements conducted by a CPA...

  18. CRYPTOSPORIDIUM LOG INACTIVATION CALCULATION METHODS

    EPA Science Inventory

    Appendix O of the Surface Water Treatment Rule (SWTR) Guidance Manual introduces the CeffT10 (i.e., reaction zone outlet C value and T10 time) method for calculating ozone CT value and Giardia and virus log inactivation. The LT2ESWTR Pre-proposal Draft Regulatory Language for St...

  19. Cattaraugus Creek Harbor, New York General Design Memorandum. Phase II. (Detailed Design). Volume II. Appendix E. Littoral Processes and Sedimentation in the Cattaraugus Embayment, New York. Appendix F. Sediment Transport in Cattaraugus Creek.

    DTIC Science & Technology

    1976-03-01

    beaches than any other part of the southeastern shoreline of Lake Erie . It is the only major sand accumulation zone with the exception of Presque Isle , in...52 20. Photographs of zonal site #10. 54 21. Photograph and map of zonal site #11, Presque Isle , Pa. 57 F22. Photographs and beach profiles at zonal...site #11. 59 23. Photograph of zonal site #12, the recurved spit area on Presque Isle , Pa. 62 24. Block diagram of recurved spit area of Presque Isle

  20. 49 CFR Appendix A to Part 222 - Approved Supplementary Safety Measures

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION USE OF LOCOMOTIVE HORNS AT PUBLIC HIGHWAY-RAIL GRADE... safety measures (SSMs) that may be installed at highway-rail grade crossings within quiet zones for risk... research and demonstration projects are completed and data is gathered and refined. Sections B and C govern...

  1. 49 CFR Appendix A to Part 222 - Approved Supplementary Safety Measures

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION USE OF LOCOMOTIVE HORNS AT PUBLIC HIGHWAY-RAIL GRADE... safety measures (SSMs) that may be installed at highway-rail grade crossings within quiet zones for risk... research and demonstration projects are completed and data is gathered and refined. Sections B and C govern...

  2. 49 CFR Appendix A to Part 222 - Approved Supplementary Safety Measures

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION USE OF LOCOMOTIVE HORNS AT PUBLIC HIGHWAY-RAIL GRADE... safety measures (SSMs) that may be installed at highway-rail grade crossings within quiet zones for risk... research and demonstration projects are completed and data is gathered and refined. Sections B and C govern...

  3. 49 CFR Appendix A to Part 222 - Approved Supplementary Safety Measures

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION USE OF LOCOMOTIVE HORNS AT PUBLIC HIGHWAY-RAIL GRADE... safety measures (SSMs) that may be installed at highway-rail grade crossings within quiet zones for risk... research and demonstration projects are completed and data is gathered and refined. Sections B and C govern...

  4. 49 CFR Appendix B to Part 222 - Alternative Safety Measures

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-Engineering ASMs, and Engineering ASMs. Modified SSMs are SSMs that do not fully comply with the provisions... reduction credit for pre-existing modified SSMs under the final rule. Non-engineering ASMs consist of... reduce risk within a quiet zone. Engineering ASMs consist of engineering improvements that address...

  5. 49 CFR Appendix B to Part 222 - Alternative Safety Measures

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...-Engineering ASMs, and Engineering ASMs. Modified SSMs are SSMs that do not fully comply with the provisions... reduction credit for pre-existing modified SSMs under the final rule. Non-engineering ASMs consist of... reduce risk within a quiet zone. Engineering ASMs consist of engineering improvements that address...

  6. 49 CFR 194.113 - Information summary.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Information summary. 194.113 Section 194.113... Response Plans § 194.113 Information summary. (a) The information summary for the core plan, required by... state(s). (b) The information summary for the response zone appendix, required in § 194.107, must...

  7. 49 CFR Appendix A to Part 611 - Description of Measures Used for Project Evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... within 1/2-mile of boarding points associated with the proposed system increment. (b) Environmental... in British Thermal Units (BTU), compared to the baseline alternative; and (3) Current Environmental...) Transit-supportive corridor policies; (5) Supportive zoning regulations near transit stations; (6) Tools...

  8. 12 CFR Appendix A to Subpart D of... - Interagency Guidelines for Real Estate Lending

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... comprehensive, and consistent with safe and sound lending practices, and must ensure that the institution... employment trends. • Zoning requirements. • Current and projected vacancy, construction, and absorption rates... property. • Maximum loan maturities by type of property. • Amortization schedules. • Pricing structure for...

  9. 12 CFR Appendix A to Subpart D of... - Interagency Guidelines for Real Estate Lending

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... comprehensive, and consistent with safe and sound lending practices, and must ensure that the institution... employment trends. • Zoning requirements. • Current and projected vacancy, construction, and absorption rates... property. • Maximum loan maturities by type of property. • Amortization schedules. • Pricing structure for...

  10. 12 CFR Appendix A to Subpart D of... - Interagency Guidelines for Real Estate Lending

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... comprehensive, and consistent with safe and sound lending practices, and must ensure that the institution... employment trends. • Zoning requirements. • Current and projected vacancy, construction, and absorption rates... property. • Maximum loan maturities by type of property. • Amortization schedules. • Pricing structure for...

  11. 40 CFR Appendix III to Part 1042 - Not-to-Exceed Zones

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... marine engines used with controllable-pitch propellers or with electrically coupled propellers, as... CONTROLS CONTROL OF EMISSIONS FROM NEW AND IN-USE MARINE COMPRESSION-IGNITION ENGINES AND VESSELS Pt. 1042... (or at Maximum Test Torque for constant-speed engines). (2) Percent speed means the percentage of...

  12. 40 CFR Appendix III to Part 1042 - Not-to-Exceed Zones

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... marine engines used with controllable-pitch propellers or with electrically coupled propellers, as... CONTROLS CONTROL OF EMISSIONS FROM NEW AND IN-USE MARINE COMPRESSION-IGNITION ENGINES AND VESSELS Pt. 1042... (or at Maximum Test Torque for constant-speed engines). (2) Percent speed means the percentage of...

  13. 40 CFR Appendix III to Part 1042 - Not-to-Exceed Zones

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... marine engines used with controllable-pitch propellers or with electrically coupled propellers, as... CONTROLS CONTROL OF EMISSIONS FROM NEW AND IN-USE MARINE COMPRESSION-IGNITION ENGINES AND VESSELS Pt. 1042... (or at Maximum Test Torque for constant-speed engines). (2) Percent speed means the percentage of...

  14. 40 CFR Appendix III to Part 1042 - Not-to-Exceed Zones

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... marine engines used with controllable-pitch propellers or with electrically coupled propellers, as... CONTROLS CONTROL OF EMISSIONS FROM NEW AND IN-USE MARINE COMPRESSION-IGNITION ENGINES AND VESSELS Pt. 1042... (or at Maximum Test Torque for constant-speed engines). (2) Percent speed means the percentage of...

  15. 40 CFR Appendix III to Part 1042 - Not-to-Exceed Zones

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... marine engines used with controllable-pitch propellers or with electrically coupled propellers, as... CONTROLS CONTROL OF EMISSIONS FROM NEW AND IN-USE MARINE COMPRESSION-IGNITION ENGINES AND VESSELS Pt. 1042... (or at Maximum Test Torque for constant-speed engines). (2) Percent speed means the percentage of...

  16. 49 CFR Appendix D to Part 222 - Determining Risk Levels

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... collision probability. There are three formulas, one for each warning device category: 1. automatic gates... risk for all public highway-rail grade crossings that are part of a quiet zone. The Prediction Formulas (a) The Prediction Formulas were developed by DOT as a guide for allocating scarce traffic safety...

  17. 49 CFR Appendix D to Part 222 - Determining Risk Levels

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... collision probability. There are three formulas, one for each warning device category: 1. automatic gates... risk for all public highway-rail grade crossings that are part of a quiet zone. The Prediction Formulas (a) The Prediction Formulas were developed by DOT as a guide for allocating scarce traffic safety...

  18. 49 CFR Appendix D to Part 222 - Determining Risk Levels

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... collision probability. There are three formulas, one for each warning device category: 1. automatic gates... risk for all public highway-rail grade crossings that are part of a quiet zone. The Prediction Formulas (a) The Prediction Formulas were developed by DOT as a guide for allocating scarce traffic safety...

  19. 49 CFR Appendix F to Subchapter B... - Commercial Zones

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ....J.; the area within the borough limits of Alpine, Tenafly, Englewood Cliffs, Leonia, Fort Lee... along U.S. Highway 40 to its junction with the Lee's Summit, Mo., corporate limits. Thence along the eastern Lee's Summit corporate limits to the Jackson-Cass County line, thence west along Jackson-Cass...

  20. A Numerical Investigation of Metabolic Reductive Dechlorination in DNAPL Source Zones

    DTIC Science & Technology

    2005-01-01

    APPENDICES ..................................................................................... 249 APPENDIX A UTCHEM VALIDATION...using UTCHEM ............................................................... 82 Table IV.2: Statistics for saturation distribution metrics in 2-D and...Saturation profiles simulated in (a) 2D using UTCHEM and (b) in the same 2D slice extracted from a 3D UTCHEM simulation

  1. Propagation and Directional Scattering of Ocean Waves in the Marginal Ice Zone and Neighboring Seas

    DTIC Science & Technology

    2015-09-30

    expected to be the average of the kernel for 10 s and 12 s. This means that we should be able to calculate empirical formulas for 2 the scattering kernel...floe packing. Thus, establish a way to incorporate what has been done by Squire and co-workers into the wave model paradigm (in which the phase of the...cases observed by Kohout et al. (2014) in Antarctica . vii. Validation: We are planning validation tests for wave-ice scattering / attenuation model by

  2. Coastal mapping handbook

    USGS Publications Warehouse

    ,; ,; Ellis, Melvin Y.

    1978-01-01

    Passage of the Coastal Zone Management Act of 1972 focused attention on the Nation's coastal land and water areas. As plans for more effective management of the coastal zone evolved, it soon became apparent that improved maps and charts of these areas were needed. This handbook was prepared with the requirements of the entire coastal community in mind, giving greatest attention to the needs of coastal zone managers and planners at the State and local levels. Its principal objective is to provide general information and guidance; it is neither a textbook nor a technical manual, but rather a primer on coastal mapping. This handbook should help planners and managers of coastal programs to determine their mapping requirements, select the best maps and charts for their particular needs, and to deal effectively with personnel who gather data and prepare maps. The sections on "Sources of Assistance and Advice" and "Product and Data Sources" should be especially useful to all involved in mapping the coastal zone. Brief summaries of the mapping efforts of several State coastal zone management programs are included. "Future outlook" discusses anticipated progress and changes in mapping procedures and techniques. Illustrations are inserted, where appropriate, to illustrate the products and equipment discussed. Because of printing restrictions, the colors in map illustrations may vary from those in the original publication. The appendixes include substantial material which also should be of interest. In addition a glossary and an index are included to provide easy and quick access to the terms and concepts used in the text. For those interested in more technical detail than is provided in this handbook, the "Selected references" will be useful. Also, the publications of the professional societies listed in appendix 4 will provide technical information in detail.

  3. 29 CFR 1608.1 - Statement of purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... upon the principles of title VII. Any uncertainty as to the meaning and application of title VII in... Commission believes that it is now necessary to clarify and harmonize the principles of title VII in order to... who comply with the principles of title VII. (b) Purposes of title VII. Congress enacted title VII in...

  4. NUSTAR AND XMM-Newton Observations of the Neutron Star X-Ray Binary 1RXS J180408.9-34205

    NASA Astrophysics Data System (ADS)

    Ludlam, Renee; Miller, Jon M.; Cackett, Edward; Fabian, Andrew C.; Bachetti, Matteo; Parker, Michael; Tomsick, John; Barret, Didier; Natalucci, Lorenzo; Rana, Vikram; Harrison, Fiona

    2016-04-01

    We report on observations of the neutron star (NS) residing in the low-mass X-ray binary 1RXS J180408.9-34205 taken 2015 March by NuSTAR and XMM-Newton while the source was in the hard spectral state. We findmultiple reflection features (Fe Kα detected with NuSTAR N VII, O VII, and O VIII detected in the RGS) fromdifferent ionization zones. Through joint fits using the self consistent relativistic reflection model RELXILL,we determine the inner radius to be 6.6(+13.2,-0.6) Rg. We find the inclination of the system to be between 18-29 degrees.If the disk is truncated at a radius greater than the innermost stable circular orbit (ISCO), then the position at which the inner disk terminates likely corresponds to the magnetospheric radius. For a spin parameter of a = 0, we estimate a conservative upper limit on the strength of the magnetic field to be B ≤ (0.9 - 3.0) × 109 G at the magnetic poles depending on the choice of conversion factor between spherical and disk accretion.

  5. Nereis alacranensis, a new species of polychaete (Annelida, Nereididae) from Alacranes Reef, southern Gulf of Mexico, with a key to Nereis from the Grand Caribbean.

    PubMed

    Ramírez Hernández, Adriana; Hernández-Alcántara, Pablo; Solís-Weiss, Vivianne

    2015-09-02

    A new species of polychaete, Nereis alacranensis n. sp., was found in dead coral rocks in the intertidal zone of Alacranes reef, southern Gulf of Mexico. N. alacranensis n. sp. can be included in a group of nereidids characterized by the absence of paragnaths in areas I and V of the pharynx, the presence of cones in a single row or absent in areas VII-VIII, and short blades in notopodial homogomph falcigers. The new species can be separated from the other species of the group by the presence of 3-7 cones in area VI and 7 cones arranged in a row in areas VII-VIII, finely dentate blades in notopodial homogomph falcigers, but most of all, by the presence of an unusual brown coarse arc shaped plate on the external ventral region of the peristomium. This structure has not yet been reported, at least in this genus. A taxonomic key of the species of Nereis recorded from the Grand Caribbean region is included.

  6. Preparation of factor VII concentrate using CNBr-activated Sepharose 4B immunoaffinity chromatography

    PubMed Central

    Mousavi Hosseini, Kamran; Nasiri, Saleh

    2015-01-01

    Background: Factor VII concentrates are used in patients with congenital or acquired factor VII deficiency or treatment of hemophilia patients with inhibitors. In this research, immunoaffinity chromatography was used to purify factor VII from prothrombin complex (Prothrombin- Proconvertin-Stuart Factor-Antihemophilic Factor B or PPSB) which contains coagulation factors II, VII, IX and X. The aim of this study was to improve purity, safety and tolerability as a highly purified factor VII concentrate. Methods: PPSB was prepared using DEAE-Sephadex and was used as the starting material for purification of coagulation factor VII. Prothrombin complex was treated by solvent/detergent at 24°C for 6 h with constant stirring. The mixture of PPSB in the PBS buffer was filtered and then chromatographed using CNBr-activated Sepharose 4B coupled with specific antibody. Factors II, IX, VII, X and VIIa were assayed on the fractions. Fractions of 48-50 were pooled and lyophilized as a factor VII concentrate. Agarose gel electrophoresis was performed and Tween 80 was measured in the factor VII concentrate. Results: Specific activity of factor VII concentrate increased from 0.16 to 55.6 with a purificationfold of 347.5 and the amount of activated factor VII (FVIIa) was found higher than PPSB (4.4-fold). Results of electrophoresis on agarose gel indicated higher purity of Factor VII compared to PPSB; these finding revealed that factor VII migrated as alpha-2 proteins. In order to improve viral safety, solvent-detergent treatment was applied prior to further purification and nearly complete elimination of tween 80 (2 μg/ml). Conclusion: It was concluded that immuonoaffinity chromatography using CNBr-activated Sepharose 4B can be a suitable choice for large-scale production of factor VII concentrate with higher purity, safety and activated factor VII. PMID:26034723

  7. Preparation of factor VII concentrate using CNBr-activated Sepharose 4B immunoaffinity chromatography.

    PubMed

    Mousavi Hosseini, Kamran; Nasiri, Saleh

    2015-01-01

    Factor VII concentrates are used in patients with congenital or acquired factor VII deficiency or treatment of hemophilia patients with inhibitors. In this research, immunoaffinity chromatography was used to purify factor VII from prothrombin complex (Prothrombin- Proconvertin-Stuart Factor-Antihemophilic Factor B or PPSB) which contains coagulation factors II, VII, IX and X. The aim of this study was to improve purity, safety and tolerability as a highly purified factor VII concentrate. PPSB was prepared using DEAE-Sephadex and was used as the starting material for purification of coagulation factor VII. Prothrombin complex was treated by solvent/detergent at 24°C for 6 h with constant stirring. The mixture of PPSB in the PBS buffer was filtered and then chromatographed using CNBr-activated Sepharose 4B coupled with specific antibody. Factors II, IX, VII, X and VIIa were assayed on the fractions. Fractions of 48-50 were pooled and lyophilized as a factor VII concentrate. Agarose gel electrophoresis was performed and Tween 80 was measured in the factor VII concentrate. Specific activity of factor VII concentrate increased from 0.16 to 55.6 with a purificationfold of 347.5 and the amount of activated factor VII (FVIIa) was found higher than PPSB (4.4-fold). RESULTS of electrophoresis on agarose gel indicated higher purity of Factor VII compared to PPSB; these finding revealed that factor VII migrated as alpha-2 proteins. In order to improve viral safety, solvent-detergent treatment was applied prior to further purification and nearly complete elimination of tween 80 (2 μg/ml). It was concluded that immuonoaffinity chromatography using CNBr-activated Sepharose 4B can be a suitable choice for large-scale production of factor VII concentrate with higher purity, safety and activated factor VII.

  8. 15 CFR Appendix II to Part 921 - Typology of National Estuarine Research Reserves

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... form. This also includes the rocky coast tidepools that fall within the intertidal zone. Dominant fauna... found above sea level in volcanic crater remnants forms as a result of poor drainage characteristics of..., American Samoa. 8. Anchialine systems: These small coastal exposures of brackish water form in lava...

  9. 15 CFR Appendix II to Part 921 - Typology of National Estuarine Research Reserves

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... form. This also includes the rocky coast tidepools that fall within the intertidal zone. Dominant fauna... found above sea level in volcanic crater remnants forms as a result of poor drainage characteristics of..., American Samoa. 8. Anchialine systems: These small coastal exposures of brackish water form in lava...

  10. 15 CFR Appendix II to Part 921 - Typology of National Estuarine Research Reserves

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... form. This also includes the rocky coast tidepools that fall within the intertidal zone. Dominant fauna... found above sea level in volcanic crater remnants forms as a result of poor drainage characteristics of..., American Samoa. 8. Anchialine systems: These small coastal exposures of brackish water form in lava...

  11. 15 CFR Appendix II to Part 921 - Typology of National Estuarine Research Reserves

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... form. This also includes the rocky coast tidepools that fall within the intertidal zone. Dominant fauna... found above sea level in volcanic crater remnants forms as a result of poor drainage characteristics of..., American Samoa. 8. Anchialine systems: These small coastal exposures of brackish water form in lava...

  12. 15 CFR Appendix II to Part 921 - Typology of National Estuarine Research Reserves

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... form. This also includes the rocky coast tidepools that fall within the intertidal zone. Dominant fauna... found above sea level in volcanic crater remnants forms as a result of poor drainage characteristics of..., American Samoa. 8. Anchialine systems: These small coastal exposures of brackish water form in lava...

  13. Disposal Site Selection Technical Appendix. Phase 2. (North and South Puget Sound)

    DTIC Science & Technology

    1989-09-01

    target species were sampled at each site. This reflects in part variation in the habitat preferences of the selected target species. The ichthyofauna ...Region. Mar. Geol., 64:291-312. Carr, W.E.S. and C.A. Adams. 1973. Food Habits of Juvenile Marine Fishes Occupying Seagrass Beds in the Estuarine Zone

  14. 49 CFR Appendix F to Subchapter B... - Commercial Zones

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Cincinnati, Ohio 8 Kansas City, Mo.-Kansas City, Kans. 9 Boston, Mass. 10 Davenport, Iowa; Rock Island and... with the right-of-way of the Chicago, Rock Island and Pacific Railroad, thence in an easterly direction... commercially a part of the San Pedro, Wilmington, and Terminal Island Districts of Los Angeles and Long Beach...

  15. 49 CFR Appendix F to Subchapter B... - Commercial Zones

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Cincinnati, Ohio 8 Kansas City, Mo.-Kansas City, Kans. 9 Boston, Mass. 10 Davenport, Iowa; Rock Island and... with the right-of-way of the Chicago, Rock Island and Pacific Railroad, thence in an easterly direction... commercially a part of the San Pedro, Wilmington, and Terminal Island Districts of Los Angeles and Long Beach...

  16. 49 CFR Appendix F to Subchapter B... - Commercial Zones

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Cincinnati, Ohio 8 Kansas City, Mo.-Kansas City, Kans. 9 Boston, Mass. 10 Davenport, Iowa; Rock Island and... with the right-of-way of the Chicago, Rock Island and Pacific Railroad, thence in an easterly direction... commercially a part of the San Pedro, Wilmington, and Terminal Island Districts of Los Angeles and Long Beach...

  17. A Mass-balance nitrate model for predicting the effects of land use on ground-water quality in municipal wellhead-protection areas

    USGS Publications Warehouse

    Frimpter, M.H.; Donohue, J.J.; Rapacz, M.V.; Beye, H.G.

    1990-01-01

    A mass-balance accounting model can be used to guide the management of septic systems and fertilizers to control the degradation of groundwater quality in zones of an aquifer that contributes water to public supply wells. The nitrate nitrogen concentration of the mixture in the well can be predicted for steady-state conditions by calculating the concentration that results from the total weight of nitrogen and total volume of water entering the zone of contribution to the well. These calculations will allow water-quality managers to predict the nitrate concentrations that would be produced by different types and levels of development, and to plan development accordingly. Computations for different development schemes provide a technical basis for planners and managers to compare water quality effects and to select alternatives that limit nitrate concentration in wells. Appendix A contains tables of nitrate loads and water volumes from common sources for use with the accounting model. Appendix B describes the preparation of a spreadsheet for the nitrate loading calculations with a software package generally available for desktop computers. (USGS)

  18. Bone Marrow Cell Transfer into Fetal Circulation Can Ameliorate Genetic Skin Diseases by Providing Fibroblasts to the Skin and Inducing Immune Tolerance

    PubMed Central

    Chino, Takenao; Tamai, Katsuto; Yamazaki, Takehiko; Otsuru, Satoru; Kikuchi, Yasushi; Nimura, Keisuke; Endo, Masayuki; Nagai, Miki; Uitto, Jouni; Kitajima, Yasuo; Kaneda, Yasufumi

    2008-01-01

    Recent studies have shown that skin injury recruits bone marrow-derived fibroblasts (BMDFs) to the site of injury to accelerate tissue repair. However, whether uninjured skin can recruit BMDFs to maintain skin homeostasis remains uncertain. Here, we investigated the appearance of BMDFs in normal mouse skin after embryonic bone marrow cell transplantation (E-BMT) with green fluorescent protein-transgenic bone marrow cells (GFP-BMCs) via the vitelline vein, which traverses the uterine wall and is connected to the fetal circulation. At 12 weeks of age, mice treated with E-BMT were observed to have successful engraftment of GFP-BMCs in hematopoietic tissues accompanied by induction of immune tolerance against GFP. We then investigated BMDFs in the skin of the same mice without prior injury and found that a significant number of BMDFs, which generate matrix proteins both in vitro and in vivo, were recruited and maintained after birth. Next, we performed E-BMT in a dystrophic epidermolysis bullosa mouse model (col7a1−/−) lacking type VII collagen in the cutaneous basement membrane zone. E-BMT significantly ameliorated the severity of the dystrophic epidermolysis bullosa phenotype in neonatal mice. Type VII collagen was deposited primarily in the follicular basement membrane zone in the vicinity of the BMDFs. Thus, gene therapy using E-BMT into the fetal circulation may offer a potential treatment option to ameliorate genetic skin diseases that are characterized by fibroblast dysfunction through the introduction of immune-tolerated BMDFs. PMID:18688022

  19. Recombinant factor VIIa treatment for asymptomatic factor VII deficient patients going through major surgery.

    PubMed

    Livnat, Tami; Shenkman, Boris; Spectre, Galia; Tamarin, Ilia; Dardik, Rima; Israeli, Amnon; Rivkind, Avraham; Shabtai, Moshe; Marinowitz, Uri; Salomon, Ophira

    2012-07-01

    Factor VII deficiency is the most common among the rare autosomal recessive coagulation disorders worldwide. In factor VII deficient patients, the severity and clinical manifestations cannot be reliably determined by factor VII levels. Severe bleeding tends to occur in individuals with factor VII activity levels of 2% or less of normal. Patients with 2-10% factor VII vary between asymptomatic to severe life threatening haemorrhages behaviour. Recombinant factor VIIa (rFVIIa) is the most common replacement therapy for congenital factor VII deficiency. However, unlike haemophilia patients for whom treatment protocols are straight forward, in asymptomatic factor VII deficiency patients it is still debatable. In this study, we demonstrate that a single and very low dose of recombinant factor VIIa enabled asymptomatic patients with factor VII deficiency to go through major surgery safely. This suggestion was also supported by thrombin generation, as well as by thromboelastometry.

  20. 19 CFR Annex Vii to Part 351 - Antidumping Investigations Timeline

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Antidumping Investigations Timeline VII Annex VII to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex VII Annex VII to Part 351—Antidumping Investigations Timeline ER19MY97.001 ...

  1. 19 CFR Annex Vii to Part 351 - Antidumping Investigations Timeline

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Antidumping Investigations Timeline VII Annex VII to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex VII Annex VII to Part 351—Antidumping Investigations Timeline ER19MY97.001 ...

  2. 19 CFR Annex Vii to Part 351 - Antidumping Investigations Timeline

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Antidumping Investigations Timeline VII Annex VII to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex VII Annex VII to Part 351—Antidumping Investigations Timeline ER19MY97.001 ...

  3. 19 CFR Annex Vii to Part 351 - Antidumping Investigations Timeline

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Antidumping Investigations Timeline VII Annex VII to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex VII Annex VII to Part 351—Antidumping Investigations Timeline ER19MY97.001 ...

  4. 19 CFR Annex Vii to Part 351 - Antidumping Investigations Timeline

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 3 2012-04-01 2012-04-01 false Antidumping Investigations Timeline VII Annex VII to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex VII Annex VII to Part 351—Antidumping Investigations Timeline ER19MY97.001 ...

  5. Gulf Coast Deep Water Port Facilities Study. Appendix C. Eastern Gulf Hydrobiological Zones.

    DTIC Science & Technology

    1973-04-01

    MARINE 5IOTA C-22 1. Benthic Plants C-22 2. Plankton C;23 3. Benthic Invertebrates C-27 4. Fish C-33 5. Marine Mammals C-35 6. Marine Birds C-37 7. Rare...56 B. RESIDENT AND TRANSIENT MARINE BIOTA C-56 1. Plankton C-56 2. Benthic Invertebrates C-62 3. Fish C-62 4. Marine Mammals C-684 Artur D Little Inc...TRANSIENT MARINE BIOTA C-78 l.-Plankton C-78 .-2. Benthic Invertebrates C8 3. F ish C-81 4. Marine Mammals C-85 V. ZONAL ANALYSIS C-87 A. ZONE V

  6. 40 CFR Appendix E to Part 63 - Monitoring Procedure for Nonthoroughly Mixed Open Biological Treatment Systems at Kraft Pulp...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... two separate components. The first data collection component demonstrates that the open biological... each zone of the open biological treatment unit. After the first two components of data collection are... determined using actual sampling data from the open biological treatment unit. This is done during the...

  7. 40 CFR Appendix E to Part 63 - Monitoring Procedure for Nonthoroughly Mixed Open Biological Treatment Systems at Kraft Pulp...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... two separate components. The first data collection component demonstrates that the open biological... each zone of the open biological treatment unit. After the first two components of data collection are... determined using actual sampling data from the open biological treatment unit. This is done during the...

  8. 49 CFR Appendix F to Subchapter B... - Commercial Zones

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., N. Mex. 18 Ravenswood, W. Va. 19 Lake Charles, La. 20 Syracuse, N.Y. 21 Baltimore, Md. 22 Cleveland... in respect of a shipment which has had a prior, or will have a subsequent movement by water carrier... Boulevard to its junction with St. Charles Rock Road, thence westerly along St. Charles Rock Road to its...

  9. 14 CFR Appendix C to Part 121 - C-46 Nontransport Category Airplanes

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... discharge shall be such as to provide a minimum of one adequate discharge for each designated fire zone... of discharging, e.g., mechanical cutterheads, electric cartridge, or other method; and whether a one- or two-shot system is used; and if the latter is used, means of cross-feeding or otherwise selecting...

  10. 40 CFR Appendix E to Part 63 - Monitoring Procedure for Nonthoroughly Mixed Open Biological Treatment Systems at Kraft Pulp...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Systems at Kraft Pulp Mills Under Unsafe Sampling Conditions I. Purpose This procedure is required to be... conditions. The purpose of this procedure is to estimate the concentration of HAP within the open biological... zones with internal recycling between the units and assuming that two Monod biological kinetic...

  11. 14 CFR Appendix C to Part 121 - C-46 Nontransport Category Airplanes

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Agency is one requiring the landing gear control to be placed in the up position in case of in-flight... airworthiness directives or FAA approved equivalent; and (2) Drain lines from supercharger case, engine-driven... discharge shall be such as to provide a minimum of one adequate discharge for each designated fire zone...

  12. 14 CFR Appendix C to Part 121 - C-46 Nontransport Category Airplanes

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Agency is one requiring the landing gear control to be placed in the up position in case of in-flight... airworthiness directives or FAA approved equivalent; and (2) Drain lines from supercharger case, engine-driven... discharge shall be such as to provide a minimum of one adequate discharge for each designated fire zone...

  13. 14 CFR Appendix C to Part 121 - C-46 Nontransport Category Airplanes

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Agency is one requiring the landing gear control to be placed in the up position in case of in-flight... airworthiness directives or FAA approved equivalent; and (2) Drain lines from supercharger case, engine-driven... discharge shall be such as to provide a minimum of one adequate discharge for each designated fire zone...

  14. 14 CFR Appendix C to Part 121 - C-46 Nontransport Category Airplanes

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Agency is one requiring the landing gear control to be placed in the up position in case of in-flight... airworthiness directives or FAA approved equivalent; and (2) Drain lines from supercharger case, engine-driven... discharge shall be such as to provide a minimum of one adequate discharge for each designated fire zone...

  15. 44 CFR Appendix A to Part 353 - Memorandum of Understanding Between Federal Emergency Management Agency and Nuclear Regulatory...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Commission on the Accident at Three Mile Island, directed that FEMA assume lead responsibility for all... can degrade the capabilities of offsite response organizations in the 10-mile plume emergency planning... affected offsite jurisdictions located in the 10-mile emergency planning zone and is not intended to be a...

  16. 44 CFR Appendix A to Part 353 - Memorandum of Understanding Between Federal Emergency Management Agency and Nuclear Regulatory...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Commission on the Accident at Three Mile Island, directed that FEMA assume lead responsibility for all... can degrade the capabilities of offsite response organizations in the 10-mile plume emergency planning... affected offsite jurisdictions located in the 10-mile emergency planning zone and is not intended to be a...

  17. Three-dimensional Monte Carlo calculation of some nuclear parameters

    NASA Astrophysics Data System (ADS)

    Günay, Mehtap; Şeker, Gökmen

    2017-09-01

    In this study, a fusion-fission hybrid reactor system was designed by using 9Cr2WVTa Ferritic steel structural material and the molten salt-heavy metal mixtures 99-95% Li20Sn80 + 1-5% RG-Pu, 99-95% Li20Sn80 + 1-5% RG-PuF4, and 99-95% Li20Sn80 + 1-5% RG-PuO2, as fluids. The fluids were used in the liquid first wall, blanket and shield zones of a fusion-fission hybrid reactor system. Beryllium (Be) zone with the width of 3 cm was used for the neutron multiplication between the liquid first wall and blanket. This study analyzes the nuclear parameters such as tritium breeding ratio (TBR), energy multiplication factor (M), heat deposition rate, fission reaction rate in liquid first wall, blanket and shield zones and investigates effects of reactor grade Pu content in the designed system on these nuclear parameters. Three-dimensional analyses were performed by using the Monte Carlo code MCNPX-2.7.0 and nuclear data library ENDF/B-VII.0.

  18. Contributions of each isotope in some fluids on neutronic performance in a fusion-fission hybrid reactor: a Monte Carlo method

    NASA Astrophysics Data System (ADS)

    Günay, M.; Şarer, B.; Kasap, H.

    2014-08-01

    In the present investigation, a fusion-fission hybrid reactor system was designed by using 9Cr2WVTa ferritic steel structural material and 99-95 % Li20Sn80-1-5 % SFG-Pu, 99-95 % Li20Sn80-1-5 % SFG-PuF4, 99-95 % Li20Sn80-1-5 % SFG-PuO2 the molten salt-heavy metal mixtures, as fluids. The fluids were used in the liquid first wall, blanket and shield zones of a fusion-fission hybrid reactor system. Beryllium zone with the width of 3 cm was used for the neutron multiplicity between liquid first wall and blanket. The contributions of each isotope in fluids on the nuclear parameters of a fusion-fission hybrid reactor such as tritium breeding ratio, energy multiplication factor, heat deposition rate were computed in liquid first wall, blanket and shield zones. Three-dimensional analyses were performed by using Monte Carlo code MCNPX-2.7.0 and nuclear data library ENDF/B-VII.0.

  19. Factor VII assay

    MedlinePlus

    Stable factor; Proconvertin; Autoprothrombin I ... be caused by an abnormally low level of factor VII. ... Decreased factor VII activity may be related to: Deficiency of factor VII Disorder in which the proteins that control ...

  20. Empirical transfer functions for stations in the Central California seismological network

    USGS Publications Warehouse

    Bakun, W.H.; Dratler, Jay

    1976-01-01

    A sequence of calibration signals composed of a station identification code, a transient from the release of the seismometer mass at rest from a known displacement from the equilibrium position, and a transient from a known step in voltage to the amplifier input are generated by the automatic daily calibration system (ADCS) now operational in the U.S. Geological Survey central California seismographic network. Documentation of a sequence of interactive programs to compute, from the calibration data, the complex transfer functions for the seismographic system (ground motion through digitizer) the electronics (amplifier through digitizer), and the seismometer alone are presented. The analysis utilizes the Fourier transform technique originally suggested by Espinosa et al (1962). Section I is a general description of seismographic calibration. Section II contrasts the 'Fourier transform' and the 'least-squares' techniques for analyzing transient calibration signals. Theoretical consideration for the Fourier transform technique used here are described in Section III. Section IV is a detailed description of the sequence of calibration signals generated by the ADCS. Section V is a brief 'cookbook description' of the calibration programs; Section VI contains a detailed sample program execution. Section VII suggests the uses of the resultant empirical transfer functions. Supplemental interactive programs by which smooth response functions, suitable for reducing seismic data to ground motion, are also documented in Section VII. Appendices A and B contain complete listings of the Fortran source Codes while Appendix C is an update containing preliminary results obtained from an analysis of some of the calibration signals from stations in the seismographic network near Oroville, California.

  1. Role of hepsin in factor VII activation in zebrafish.

    PubMed

    Khandekar, Gauri; Jagadeeswaran, Pudur

    2014-01-01

    Factor VII, the initiator of the extrinsic coagulation cascade, circulates in human plasma mainly in its zymogen form, factor VII and in small amounts in its activated form, factor VIIa. However, the mechanism of initial generation of factor VIIa is not known despite intensive research using currently available model systems. Earlier findings suggested serine proteases factor VII activating protease and hepsin play a role in activating factor VII, however, it has remained controversial. In this paper we estimated the levels of factor VIIa and factor VII for the first time in zebrafish adult population and also reevaluated the role of the above two serine proteases in activating factor VII in vivo using zebrafish as a model system. Knockdown of factor VII activating protease and hepsin was performed followed by assaying for their effect on factor VIIa concentration and extrinsic coagulation as measured by the kinetic prothrombin time. Factor VII activating protease knockdown showed no change in kinetic prothrombin time and no effect on factor VIIa levels while hepsin knockdown increased the kinetic prothrombin time and significantly reduced the factor VIIa plasma levels. Our results thus indicate that hepsin plays a physiologically important role in factor VII activation and hemostasis in zebrafish. © 2013.

  2. Genetics Home Reference: factor VII deficiency

    MedlinePlus

    ... Facebook Twitter Home Health Conditions Factor VII deficiency Factor VII deficiency Printable PDF Open All Close All Enable Javascript to view the expand/collapse boxes. Description Factor VII deficiency is a rare bleeding disorder that varies ...

  3. First living-related liver transplant to cure factor VII deficiency.

    PubMed

    Mohan, Neelam; Karkra, Sakshi; Jolly, Anu S; Vohra, Vijay; Mohanka, Ravi; Rastogi, Amit; Soin, A S

    2015-09-01

    Congenital factor VII deficiency is an autosomal recessive serious disorder of blood coagulation with wide genotypic and phenotypic variations. The clinical presentation can vary from asymptomatic patients to patients with major bleedings in severe deficiency (factor VII <1%). Investigations show prolonged PT and low factor VII. Treatment modalities include FFP and repeated recombinant factor VII infusions. We hereby report the first successful LRLT for factor VII deficiency in an infant, the first-ever youngest baby reported worldwide. A six-month-old male child presented with easy bruisability, ecchymotic patches, hematuria, and convulsions. CT of the head showed subdural hemorrhage, which was treated conservatively. He had markedly increased PT (120 s) with normal platelets, and aPTT with factor VII level <1%. Despite the treatment by rFVIIa administration weekly, which was very expensive, he still had repeated life-threatening bleeding episodes. LRLT was performed with mother as the donor, whose factor VII level was 57%. A factor VII infusion plan for pre-, intra- and postoperative periods was formulated and TEG followed. Postoperatively, his factor VII started increasing from third day and was 38% on 24th day with PT <14 s. He had uneventful intraoperative and postoperative courses. LT is a safe and definite cure for factor VII deficiency. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  4. 19 CFR Appendix to Part 146 - Guidelines for Determining Producibility and Relative Values for Oil Refinery Zones

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Producibility Showing Manufacturing Periods From Admission t o Removal Within a Calender Month. Volume losses and gains accounted for by weight. Day 1 Receipt into the refinery subzone during a 30-day month: 50... 50,000 pounds of aviation gasoline. The period of manufacture for the aviation gasoline is Day 1 to...

  5. 19 CFR Appendix to Part 146 - Guidelines for Determining Producibility and Relative Values for Oil Refinery Zones

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Producibility Showing Manufacturing Periods From Admission t o Removal Within a Calender Month. Volume losses and gains accounted for by weight. Day 1 Receipt into the refinery subzone during a 30-day month: 50... 50,000 pounds of aviation gasoline. The period of manufacture for the aviation gasoline is Day 1 to...

  6. 19 CFR Appendix to Part 146 - Guidelines for Determining Producibility and Relative Values for Oil Refinery Zones

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Producibility Showing Manufacturing Periods From Admission to Removal Within a Calendar Month. Volume losses and gains accounted for by weight. Day 1 Receipt into the refinery subzone during a 30-day month: 50,000... pounds of aviation gasoline. The period of manufacture for the aviation gasoline is Day 1 to Day 10. The...

  7. Earth resources requirements Skylab missions SL-1/SL-2, SL-3, and SL-4. Appendix B: Mission requirements

    NASA Technical Reports Server (NTRS)

    1972-01-01

    Earth resources requirements to be investigated by Skylab missions 1 through 4 are presented tabularly. Areas to be investigated include: (1) agriculture, range, and forestry; (2) geology; (3) continental water resources; (4) ocean investigations; (5) atmospheric investigations; (6) coastal zones, shoals, and bays; (7) remote sensing techniques; and (8) cartography.

  8. Recharge

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fayer, Michael J.

    2008-01-17

    This chapter describes briefly the nature and measurement of recharge in support of the CH2M HILL Tank Farm Vadose Zone Project. Appendix C (Recharge) and the Recharge Data Package (Fayer and Keller 2007) provide a more thorough and extensive review of the recharge process and the estimation of recharge rates for the forthcoming RCRA Facility Investigation report for Hanford single-shell tank (SST) Waste Management Areas (WMAs).

  9. 32 CFR Appendix A to Part 110 - Climatic Zones Used To Determine Rates of Commutation Allowance

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... Louisiana 11. Mississippi 12. New Mexico, only 100 mile-wide belt along south border 13. North Carolina 14.... Montana 22. Nebraska 23. Nevada 24. New Hampshire 25. New Jersey 26. New Mexico, except a 100 mile-wide belt along south border 27. New York 28. North Dakota 29. Ohio 30. Oklahoma, except the southeast...

  10. Blood glucose may condition factor VII levels in diabetic and normal subjects.

    PubMed

    Ceriello, A; Giugliano, D; Quatraro, A; Dello Russo, P; Torella, R

    1988-12-01

    Increased factor VII levels have been reported in Type 1 (insulin-dependent) diabetic subjects. A direct correlation between fasting plasma glucose and factor VII level was found to exist in both diabetic and normal subjects. Induced-hyperglycaemia was able to increase factor VII levels in both diabetic patients and normal control subjects while, when euglycaemia was achieved in diabetic patients, factor VII values returned to normal range. This study shows that the level of factor VII may be directly conditioned by circulating blood glucose and, therefore, stresses the role of hyperglycaemia in conditioning coagulation abnormalities in diabetes mellitus.

  11. Altered lumbar spine structure, biochemistry and biomechanical properties in a canine model of mucopolysaccharidosis type VII

    PubMed Central

    Smith, Lachlan J; Martin, John T; Szczesny, Spencer E; Ponder, Katherine P; Haskins, Mark E; Elliott, Dawn M

    2010-01-01

    Mucopolysaccharidosis VII (MPS VII) is a lysosomal storage disorder characterized by a deficiency in β-glucuronidase activity, leading to systemic accumulation of poorly degraded glycosaminoglycans (GAG). Along with other morbidities, MPS VII is associated with paediatric spinal deformity. The objective of this study was to examine potential associations between abnormal lumbar spine matrix structure and composition in MPS VII, and spine segment and tissue-level mechanical properties, using a naturally occurring canine model with a similar clinical phenotype to the human form of the disorder. Segments from juvenile MPS VII and unaffected dogs were allocated to: radiography, gross morphology, histology, biochemistry, and mechanical testing. MPS VII spines had radiolucent lesions in the vertebral body epiphyses. Histologically, this corresponded to a GAG-rich cartilaginous region in place of bone, and elevated GAG staining was seen in the annulus fibrosus. Biochemically, MPS VII samples had elevated GAG in the outer annulus fibrosus and epiphyses, low calcium in the epiphyses, and high water content in all regions except the nucleus pulposus. MPS VII spine segments had higher range of motion and lower stiffness than controls. Endplate indentation stiffness and failure loads were significantly lower in MPS VII samples, while annulus fibrosus tensile mechanical properties were normal. Vertebral body lesions in MPS VII spines suggest a failure to convert cartilage to bone during development. Low stiffness in these regions likely contributes to mechanical weakness in motion segments and is a potential factor in the progression of spinal deformity. PMID:19918911

  12. Characterization of the Hosgri Fault Zone and adjacent structures in the offshore Santa Maria Basin, south-central California: Chapter CC of Evolution of sedimentary basins/onshore oil and gas investigations - Santa Maria province

    USGS Publications Warehouse

    Willingham, C. Richard; Rietman, Jan D.; Heck, Ronald G.; Lettis, William R.

    2013-01-01

    The Hosgri Fault Zone trends subparallel to the south-central California coast for 110 km from north of Point Estero to south of Purisima Point and forms the eastern margin of the present offshore Santa Maria Basin. Knowledge of the attributes of the Hosgri Fault Zone is important for petroleum development, seismic engineering, and environmental planning in the region. Because it lies offshore along its entire reach, our characterizations of the Hosgri Fault Zone and adjacent structures are primarily based on the analysis of over 10,000 km of common-depth-point marine seismic reflection data collected from a 5,000-km2 area of the central and eastern parts of the offshore Santa Maria Basin. We describe and illustrate the along-strike and downdip geometry of the Hosgri Fault Zone over its entire length and provide examples of interpreted seismic reflection records and a map of the structural trends of the fault zone and adjacent structures in the eastern offshore Santa Maria Basin. The seismic data are integrated with offshore well and seafloor geologic data to describe the age and seismic appearance of offshore geologic units and marker horizons. We develop a basin-wide seismic velocity model for depth conversions and map three major unconformities along the eastern offshore Santa Maria Basin. Accompanying plates include maps that are also presented as figures in the report. Appendix A provides microfossil data from selected wells and appendix B includes uninterpreted copies of the annotated seismic record sections illustrated in the chapter. Features of the Hosgri Fault Zone documented in this investigation are suggestive of both lateral and reverse slip. Characteristics indicative of lateral slip include (1) the linear to curvilinear character of the mapped trace of the fault zone, (2) changes in structural trend along and across the fault zone that diminish in magnitude toward the ends of the fault zone, (3) localized compressional and extensional structures characteristic of constraining and releasing bends and stepovers, (4) changes in the sense and magnitude of vertical separation along strike within the fault zone, and (5) changes in downdip geometry between the major traces and segments of the fault zone. Characteristics indicative of reverse slip include (1) reverse fault geometries that occur across major strands of the fault zone and (2) fault-bend folds and localized thrust faults that occur along the northern and southern reaches of the fault. Analyses of high-resolution, subbottom profiler and side-scan sonar records indicate localized Holocene activity along most of the extent of the fault zone. Collectively, these features are the basis of our characterization of the Hosgri Fault Zone as an active, 110-km-long, convergent right-oblique slip (transpressional) fault with identified northern and southern terminations. This interpretation is consistent with recently published analyses of onshore geologic data, regional tectonic kinematic models, and instrumental seismicity.

  13. U.S.-Soviet Collaborative Geological and Geophysical Survey of the Mid-Atlantic Ridge near 31 degrees N, the Petrov Fracture Zone

    USGS Publications Warehouse

    Klitgord, Kim D.; Dmitriev, Leonard V.; Casey, John F.; Silantiev, Sergei; Johnson, Kevin

    1993-01-01

    IntroductionIn February 1989, the first formal U.S.-Soviet joint marine geologic-geophysical study in 10 years was undertaken along the Mid-Atlantic Ridge near 31°N on the 12th Cruise of the RN Akademik Boris Petrov of the Vernadsky Institute of Geochemistry (USSR Academy of Sciences, Moscow). This survey was initiated as part of the U.S.S.R.-U.S. cooperative research project "Mid-Atlantic Ridge Crest Processes" within the framework of the Soviet-U.S. bilateral Ocean Studies Agreement (Ostenso, 1989). U.S. scientists from the U.S. Geological Survey, University of Houston, and Woods Hole Oceanographic Institution participated in this program with Soviet scientists from the Vernadsky Institute of Geochemistry, Institute of Geology, and Schmidt Institute of Physics of the Earth, all institutes of the USSR Academy of Sciences in Moscow (Appendix 1 ). The ship departed from Rotterdam, Nederlands on February 2, 1989 and docked in Bridgetown, Barbados on February 28, 1989. A log of the ship's schedule during this cruise is given in Appendix 2. This study involved a limited multibeam-bathymetric, gravity, magnetic, and seismic- reflection survey. and dredging program of a short-offset transform fault named the Petrov Fracture Zone near 31 °N, located just north of the Atlantis Fracture Zone on the Mid Atlantic Ridge. A site survey at King's Trough in the northeast Atlantic for a MIR submersible program in June 1989 was originally planned as part of this program, but bad weather and the resultant poor quality geophysical data forced this work to be terminated after only one day. Nearly 6000 km of geophysical profile data and 13 dredge stations were completed during this cruise. A description of the geophysical systems aboard the RN Petrov is given in Appendices 3 and 4. All geophysical data were recorded on magnetic tape in data formats described in Appendix 5. Dredge locales and description summaries only are presented in Appendix 6. Detailed descriptions of dredge samples will be presented elsewhere. Operational plan for the studies on this cruise was developed as a cooperative effort between U.S. and Soviet scientists, who established jointly the basic objectives of the study. The U.S. scientists were given the responsibility for developing the detailed survey and dredge sampling plans. Dredge operations and basic geophysical systems operations were the responsibility of the Soviet personnel.

  14. Tissue Factor-Factor VII Complex As a Key Regulator of Ovarian Cancer Phenotypes.

    PubMed

    Koizume, Shiro; Miyagi, Yohei

    2015-01-01

    Tissue factor (TF) is an integral membrane protein widely expressed in normal human cells. Blood coagulation factor VII (fVII) is a key enzyme in the extrinsic coagulation cascade that is predominantly secreted by hepatocytes and released into the bloodstream. The TF-fVII complex is aberrantly expressed on the surface of cancer cells, including ovarian cancer cells. This procoagulant complex can initiate intracellular signaling mechanisms, resulting in malignant phenotypes. Cancer tissues are chronically exposed to hypoxia. TF and fVII can be induced in response to hypoxia in ovarian cancer cells at the gene expression level, leading to the autonomous production of the TF-fVII complex. Here, we discuss the roles of the TF-fVII complex in the induction of malignant phenotypes in ovarian cancer cells. The hypoxic nature of ovarian cancer tissues and the roles of TF expression in endometriosis are discussed. Arguments will be extended to potential strategies to treat ovarian cancers based on our current knowledge of TF-fVII function.

  15. Functional topography of the cerebellum for motor and cognitive tasks: an fMRI study

    PubMed Central

    Stoodley, Catherine J.; Valera, Eve M.; Schmahmann, Jeremy D.

    2011-01-01

    Anatomical, clinical and imaging findings suggest that the cerebellum is engaged in cognitive and affective functions as well as motor control. Evidence from converging modalities also indicates that there is a functional topography in the human cerebellum for overt control of movement vs. higher functions, such that the cerebellum can be divided into zones depending on connectivity with sensorimotor vs. multimodal association cortices. Using functional MRI, we show that regions active during overt movement differ from those involved in higher-level language, spatial processing and working memory tasks. Nine healthy participants each completed five tasks in order to determine the relative activation patterns for the different paradigms. Right-handed finger-tapping activated right cerebellar lobules IV-V and VIII, consistent with descriptions of the cerebellar homunculi. Verb generation engaged right cerebellar lobules VI-Crus I and a second cluster in lobules VIIB-VIIIA. Mental rotation activation peaks were localized to medial left cerebellar lobule VII (Crus II). A 2-back working memory task activated bilateral regions of lobules VI-VII. Viewing arousing vs. neutral images did not reliably activate the cerebellum or cerebral limbic areas in this study. The cerebellar functional topography identified in this study reflects the involvement of different cerebro-cerebellar circuits depending on the demands of the task being performed: overt movement activated sensorimotor cortices along with contralateral cerebellar lobules IV-VI and VIII, whereas more cognitively demanding tasks engaged prefrontal and parietal cortices along with cerebellar lobules VI and VII. These findings provide further support for a cerebellar role in both motor and cognitive tasks, and better establish the existence of functional subregions in the cerebellum. Future studies are needed to determine the exact contribution of the cerebellum – and different cerebro-cerebellar circuits – to task performance. PMID:21907811

  16. Prophylaxis in congenital factor VII deficiency: indications, efficacy and safety. Results from the Seven Treatment Evaluation Registry (STER).

    PubMed

    Napolitano, Mariasanta; Giansily-Blaizot, Muriel; Dolce, Alberto; Schved, Jean F; Auerswald, Guenter; Ingerslev, Jørgen; Bjerre, Jens; Altisent, Carmen; Charoenkwan, Pimlak; Michaels, Lisa; Chuansumrit, Ampaiwan; Di Minno, Giovanni; Caliskan, Umran; Mariani, Guglielmo

    2013-04-01

    Because of the very short half-life of factor VII, prophylaxis in factor VII deficiency is considered a difficult endeavor. The clinical efficacy and safety of prophylactic regimens, and indications for their use, were evaluated in factor VII-deficient patients in the Seven Treatment Evaluation Registry. Prophylaxis data (38 courses) were analyzed from 34 patients with severe factor VII deficiency (<1-45 years of age, 21 female). Severest phenotypes (central nervous system, gastrointestinal, joint bleeding episodes) were highly prevalent. Twenty-one patients received recombinant activated factor VII (24 courses), four received plasma-derived factor VII, and ten received fresh frozen plasma. Prophylactic schedules clustered into "frequent" courses (three times weekly, n=23) and "infrequent" courses (≤ 2 times weekly, n=15). Excluding courses for menorrhagia, "frequent" and "infrequent" courses produced 18/23 (78%) and 5/12 (41%) "excellent" outcomes, respectively; relative risk, 1.88; 95% confidence interval, 0.93-3.79; P=0.079. Long term prophylaxis lasted from 1 to >10 years. No thrombosis or new inhibitors occurred. In conclusion, a subset of patients with factor VII deficiency needed prophylaxis because of severe bleeding. Recombinant activated factor VII schedules based on "frequent" administrations (three times weekly) and a 90 μg/kg total weekly dose were effective. These data provide a rationale for long-term, safe prophylaxis in factor VII deficiency.

  17. Intelsat VII program and the future

    NASA Astrophysics Data System (ADS)

    Madon, P. J.; Sachdev, D. K.

    The evolution of the Intelsat VII spacecraft is discussed. The role of competitive procurement process in this evolution is addressed, and the overall system-level features of the spacecraft are reviewed. The time frame for the five Intelsat VII missions is summarized, and follow-up projects to Intelsat VII are discussed.

  18. Use of recombinant factor VII for tooth extractions in a patient with severe congenital factor VII deficiency: a case report.

    PubMed

    Weinstock, Robert J; Onyejiuwa, Andrew; Shnayder, Garry; Clarkson, Earl I

    2015-04-01

    Patients with factor VII deficiency have an increased risk of prolonged perioperative hemorrhage. In this article, the authors present a case of severe factor VII deficiency in a patient who required tooth extraction. A 44-year-old woman with severe congenital factor VII deficiency sought care for a symptomatic, carious, and nonrestorable maxillary right second molar that required extraction. The authors obtained hematologic consultation, and the patient underwent the extraction under general anesthesia in the inpatient setting. Perioperative management included performing relevant laboratory studies, preoperative recombinant factor VII infusion, and postoperative intravenous aminocaproic acid administration. No hemorrhagic complications occurred throughout the perioperative course. The degree of factor VII deficiency correlates poorly with bleeding risk. Perioperative management is variable, requiring preoperative consultation with a hematologist. Copyright © 2015 American Dental Association. Published by Elsevier Inc. All rights reserved.

  19. Synergistic effect of factor VII gene polymorphisms causing mild factor VII deficiency in a case of severe factor X deficiency.

    PubMed

    Deshpande, Rutuja; Ghosh, Kanjaksha; Shetty, Shrimati

    2017-01-01

    Congenital combined deficiency of coagulation factors VII and X are mainly attributed to large deletions involving both the genes in chromosome 13 or occasionally due to the coincidental occurrence of independently occurring mutations. We report the molecular basis of congenital combined deficiency of factors VII and X in a 6-year-old female child. Direct DNA sequencing of both factor VII (F7) and factor X (F10) genes showed a novel homozygous missense mutation p.Cys90Tyr (c.307G>A) in exon 4 of F10. No mutations were detected in F7; however, the patient was homozygous for three polymorphic alleles known to be associated with reduced factor VII levels. The present case illustrates the synergistic effect of multiple polymorphisms resulting in phenotypic factor VII deficiency in the absence of a pathogenic mutation.

  20. 77 FR 5396 - Recordkeeping and Reporting Requirements Under Title VII, the ADA, and GINA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-03

    ... Requirements Under Title VII, the ADA, and GINA AGENCY: Equal Employment Opportunity Commission. ACTION: Final... rule, extends its existing recordkeeping requirements under title VII of the Civil Rights Act of 1964 (Title VII) and the Americans with Disabilities Act (ADA) to entities covered by title II of the Genetic...

  1. 76 FR 31892 - Recordkeeping and Reporting Requirements Under Title VII, the ADA, and GINA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ... Requirements Under Title VII, the ADA, and GINA AGENCY: Equal Employment Opportunity Commission. ACTION: Notice...'' or ``Commission'') proposes to extend its existing recordkeeping requirements under title VII of the Civil Rights Act of 1964 (Title VII) and the Americans with Disabilities Act (ADA) to entities covered...

  2. Recombinant activated factor VII in cardiac surgery: single-center experience.

    PubMed

    Singh, Sarvesh Pal; Chauhan, Sandeep; Choudhury, Minati; Malik, Vishwas; Choudhary, Shiv Kumar

    2014-02-01

    The widespread off-label use of recombinant activated factor VII for the control of refractory postoperative hemorrhage continues despite a warning from the Food and Drug Administration. Although effective in reducing the need for transfusion of blood and blood products, safety concerns still prevail. To compare the dosing and efficacy of recombinant activated factor VII between pediatric and adult patients, and in the operating room and intensive care unit. The records of 69 patients (33 children and 36 adults) who underwent cardiovascular surgery and received recombinant activated factor VII were reviewed retrospectively. The dose of recombinant activated factor VII, mediastinal drainage, use of blood and blood products, incidence of thrombosis, and 28-day mortality were studied. the efficacy of recombinant activated factor VII was comparable in adults and children, despite the lower dose in adults. Prophylactic use of recombinant activated factor VII decreased the incidence of mediastinal exploration and the duration of intensive care unit stay. A 4.3% incidence of thrombotic complications was observed in this study. The efficacious dose of recombinant activated factor VII is much less in adults compared to children. Prophylactic use of recombinant activated factor VII decreases the dose required, the incidence of mediastinal exploration, and intensive care unit stay, with no survival benefit.

  3. Life-threatening bleeding in a case of autoantibody-induced factor VII deficiency.

    PubMed

    Okajima, K; Ishii, M

    1999-02-01

    A male patient presented with life-threatening bleeding induced by autoantibody-induced factor VII (F.VII) deficiency. This patient had macroscopic hematuria, skin ecchymosis, gastrointestinal bleeding, and a neck hematoma that was causing disturbed respiration. He developed acute renal failure and acute hepatic failure, probably due to obstruction of the ureters and the biliary tract, respectively. Although activated partial thromboplastin time was normal, prothrombin time (PT) was remarkably prolonged at 71.8 seconds compared to 14.0 seconds in a normal control. Both the immunoreactive level of F.VII antigen and the F.VII activity of the patient's plasma samples were < 1.0% of normal. Although an equal part of normal plasma was added to the patient's plasma, PT was not corrected. The patient's plasma inhibited F.VII activity. These findings suggested the presence of a plasma inhibitor for F.VII. After administration of large doses of methylprednisolone, PT was gradually shortened and plasma levels of F.VII increased over time. Bleeding, acute renal failure, and acute hepatic failure improved markedly following the steroid treatment. These observations suggest that life-threatening bleeding can be induced by autoantibody-induced F.VII deficiency and that immunosuppressive therapy using large doses of steroid can be successful in inhibiting the production of the autoantibody.

  4. Factor VII deficiency: a novel missense variant and genotype-phenotype correlation in patients from Southern Italy.

    PubMed

    Tiscia, Giovanni; Favuzzi, Giovanni; Chinni, Elena; Colaizzo, Donatella; Fischetti, Lucia; Intrieri, Mariano; Margaglione, Maurizio; Grandone, Elvira

    2017-01-01

    This study aimed at attempting to correlate genotype and phenotype in factor VII deficiency. Here, we present molecular and clinical findings of 10 patients with factor VII deficiency. From 2013 to 2016, 10 subjects were referred to our center because of a prolonged prothrombin time identified during routine or presurgery examinations or after a laboratory assessment of a bleeding episode. Mutation characterization was performed using the bioinformatics applications PROMO, SIFT, and Polyphen-2. Structural changes in the factor VII protein were analyzed using the SPDB viewer tool. Of the 10 variants we identified, 1 was responsible for a novel missense change (c.1199G>C, p.Cys400Ser); in 2 cases we identified the c.-54G>A and c.509G>A (p.Arg170His) polymorphic variants in the 5'-upstream region of the factor VII gene and exon 6, respectively. To our knowledge, neither of these polymorphic variants has been described previously in factor VII-deficient patients. In silico predictions showed differences in binding sites for transcription factors caused by the c.-54G>A variant and a probable damaging effect of the p.Cys400Ser missense change on factor VII active conformation, leading to breaking of the Cys400-Cys428 disulfide bridge. Our findings further suggest that, independently of factor VII levels and of variants potentially affecting factor VII levels, environmental factors, e.g., trauma, could heavily influence the clinical phenotype of factor VII-deficient patients.

  5. A core viral protein binds host nucleosomes to sequester immune danger signals

    PubMed Central

    Avgousti, Daphne C.; Herrmann, Christin; Kulej, Katarzyna; Pancholi, Neha J.; Sekulic, Nikolina; Petrescu, Joana; Molden, Rosalynn C.; Blumenthal, Daniel; Paris, Andrew J.; Reyes, Emigdio D.; Ostapchuk, Philomena; Hearing, Patrick; Seeholzer, Steven H.; Worthen, G. Scott; Black, Ben E.; Garcia, Benjamin A.; Weitzman, Matthew D.

    2016-01-01

    Viral proteins mimic host protein structure and function to redirect cellular processes and subvert innate defenses1. Small basic proteins compact and regulate both viral and cellular DNA genomes. Nucleosomes are the repeating units of cellular chromatin and play an important role in innate immune responses2. Viral encoded core basic proteins compact viral genomes but their impact on host chromatin structure and function remains unexplored. Adenoviruses encode a highly basic protein called protein VII that resembles cellular histones3. Although protein VII binds viral DNA and is incorporated with viral genomes into virus particles4,5, it is unknown whether protein VII impacts cellular chromatin. Our observation that protein VII alters cellular chromatin led us to hypothesize that this impacts antiviral responses during adenovirus infection. We found that protein VII forms complexes with nucleosomes and limits DNA accessibility. We identified post-translational modifications on protein VII that are responsible for chromatin localization. Furthermore, proteomic analysis demonstrated that protein VII is sufficient to alter protein composition of host chromatin. We found that protein VII is necessary and sufficient for retention in chromatin of members of the high-mobility group protein B family (HMGB1, HMGB2, and HMGB3). HMGB1 is actively released in response to inflammatory stimuli and functions as a danger signal to activate immune responses6,7. We showed that protein VII can directly bind HMGB1 in vitro and further demonstrated that protein VII expression in mouse lungs is sufficient to decrease inflammation-induced HMGB1 content and neutrophil recruitment in the bronchoalveolar lavage fluid. Together our in vitro and in vivo results show that protein VII sequesters HMGB1 and can prevent its release. This study uncovers a viral strategy in which nucleosome binding is exploited to control extracellular immune signaling. PMID:27362237

  6. Is prophylaxis required for delivery in women with factor VII deficiency?

    PubMed Central

    Baumann Kreuziger, Lisa M.; Morton, Colleen T.; Reding, Mark T.

    2013-01-01

    Introduction Factor VII (fVII) deficiency is a rare congenital bleeding disorder in which fVII activity level and bleeding tendency do not completely correlate. Pregnancy and delivery present a significant hemostatic challenge to women with fVII deficiency. Treatment with recombinant factor VIIa (rfVIIa) carries a thrombotic risk and the literature is unclear whether prophylaxis is necessary prior to delivery. Aim To define management, hemorrhagic and thrombotic complications of pregnant women with fVII deficiency through a systematic review. Methods Medical databases (PubMed, MEDLINE, CINAHL, Academic Search Premier, Cochrane Library, Web of Science and Scopus) were searched using “factor VII deficiency” and “pregnancy” or “surgery.” Overall 34 articles, 4 abstracts, and 3 institutional cases were reviewed. Results Literature from 1953–2011 reported 94 live births from 62 women with fVII deficiency. The median fVII activity was 5.5%. Hemostatic prophylaxis was used in 32% of deliveries. Without prophylaxis, 40 vaginal deliveries and 16 cesarean sections were completed. The odds of receiving prophylaxis were 2.9 times higher in women undergoing cesarean section compared to vaginal delivery. Post-partum hemorrhage occurred in 10% of deliveries with prophylaxis and 13% of deliveries without prophylaxis. The fVII level did not significantly differ between women who did and did not receive prophylaxis. Conclusion We present the only systematic review of the management of pregnancy in fVII deficient women. No difference in post-partum hemorrhage was seen in deliveries with and without prophylaxis. Therefore we recommend that rfVIIa be available in the case of hemorrhage or surgical intervention, but not as mandatory prophylaxis. PMID:23607277

  7. Modified Filamentous Bacteriophage as a Scaffold for Carbon Nanofiber.

    PubMed

    Szot-Karpińska, Katarzyna; Golec, Piotr; Leśniewski, Adam; Pałys, Barbara; Marken, Frank; Niedziółka-Jönsson, Joanna; Węgrzyn, Grzegorz; Łoś, Marcin

    2016-12-21

    With the advent of nanotechnology, carbon nanomaterials such as carbon nanofibers (CNF) have aroused substantial interest in various research fields, including energy storage and sensing. Further improvement of their properties might be achieved via the application of viral particles such as bacteriophages. In this report, we present a filamentous M13 bacteriophage with a point mutation in gene VII (pVII-mutant-M13) that selectively binds to the carbon nanofibers to form 3D structures. The phage-display technique was utilized for the selection of the pVII-mutant-M13 phage from the phage display peptide library. The properties of this phage make it a prospective candidate for a scaffold material for CNFs. The results for binding of CNF by mutant phage were compared with those for maternal bacteriophage (pVII-M13). The efficiency of binding between pVII-mutant-M13 and CNF is about 2 orders of magnitude higher compared to that of the pVII-M13. Binding affinity between pVII-mutant-M13 and CNF was also characterized using atomic force microscopy, scanning electron microscopy, and transmission electron microscopy, which confirmed the specificity of the interaction of the phage pVII-mutant-M13 and the CNF; the binding occurs via the phage's ending, where the mutated pVII protein is located. No similar behavior has been observed for other carbon nanomaterials such as graphite, reduced graphene oxide, single-walled carbon nanotubes, and multiwalled carbon nanotubes. Infrared spectra confirmed differences in the interaction with CNF between the pVII-mutant-M13 and the pVII-M13. Basing on conducted research, we hypothesize that the interactions are noncovalent in nature, with π-π interactions playing the dominant role. Herein, the new bioconjugate material is introduced.

  8. Is prophylaxis required for delivery in women with factor VII deficiency?

    PubMed

    Baumann Kreuziger, L M; Morton, Colleen T; Reding, Mark T

    2013-11-01

    Factor VII (fVII) deficiency is a rare congenital bleeding disorder in which fVII activity level and bleeding tendency do not completely correlate. Pregnancy and delivery present a significant haemostatic challenge to women with fVII deficiency. Treatment with recombinant factor VIIa (rfVIIa) carries a thrombotic risk and the literature is not clear whether prophylaxis is necessary prior to delivery. The aim of this study was to define management, haemorrhagic and thrombotic complications of pregnant women with fVII deficiency through a systematic review. Medical databases (PubMed, MEDLINE, CINAHL, Academic Search Premier, Cochrane Library, Web of Science and Scopus) were searched using "factor VII deficiency" and "pregnancy" or "surgery." Overall 34 articles, four abstracts, and three institutional cases were reviewed. Literature from 1953 to 2011 reported 94 live births from 62 women with fVII deficiency. The median fVII activity was 5.5%. Haemostatic prophylaxis was used in 32% of deliveries. Without prophylaxis, 40 vaginal deliveries and 16 caesarean sections were completed. The odds of receiving prophylaxis were 2.9 times higher in women undergoing caesarean section compared to vaginal delivery. Post-partum haemorrhage occurred in 10% of deliveries with prophylaxis and 13% of deliveries without prophylaxis. The fVII level did not significantly differ between women who did and did not receive prophylaxis. We present the only systematic review of the management of pregnancy in fVII deficient women. No difference in post-partum haemorrhage was seen in deliveries with and without prophylaxis. Therefore, we recommend that rfVIIa be available in the case of haemorrhage or surgical intervention, but not as mandatory prophylaxis. © 2013 John Wiley & Sons Ltd.

  9. Onset of Tlx-3 expression in the chick cerebellar cortex correlates with the morphological development of fissures and delineates a posterior transverse boundary.

    PubMed

    Logan, Cairine; Millar, Cassie; Bharadia, Vinay; Rouleau, Katherine

    2002-06-24

    Recent studies have shown that the mammalian cerebellar cortex can be subdivided into a reproducible array of zones and stripes. In particular, discontinuous patterns of gene expression together with mutational analysis suggest that there are at least four distinct transverse zones along the rostrocaudal axis in mouse: the anterior zone (lobules I-V), the central zone (lobules VI and VII), the posterior zone (lobules VIII and IX), and the nodular zone (lobule X). Here we show that the divergent homeobox-containing transcription factor, Tlx- 3 (also known as Hox11L2 or Rnx) is transiently expressed in external granule cells in a distinct transverse domain of the developing chick cerebellar cortex. Expression is first detected at Hamburger and Hamilton (HH) stage 35. Interestingly, Tlx-3 mRNA expression is initially confined to, and coincident with, the morphological development of fissures. Slightly later, at HH stage 38, expression extends throughout the developing external granular layer (EGL) of lobules I-IXab. Notably, no Tlx-3 expression was detected in lobules IXc and X at any developmental time point examined. Expression is noticeably stronger in nonproliferating cells located in the deep layer of the EGL. Tlx-3 expression is downregulated as granule cells migrate inward to form the internal granule layer and is undetectable shortly after birth. These results suggest that Tlx-3 is expressed as granule cells become postmitotic and suggest that Tlx-3 may play a role in the differentiation of distinct neuronal populations in the cerebellum. Copyright 2002 Wiley-Liss, Inc.

  10. Miscellaneous chemical basin expedited site characterization report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Riha, B.D.; Pemberton, B.E.; Rossabi, J.

    1996-12-01

    A total of twenty nine cone penetrometer test (CPT) pushes in three weeks were conducted for vadose zone characterization of the Miscellaneous Chemical Basin (MCB) waste unit at the Savannah River Site. The shallow, unlined basin received liquid chemical wastes over an 18 year period beginning in 1956. This characterization was initiated to determine the vertical and lateral extent of contamination in the vadose zone and to install vadose zone wells for remediation by barometric pumping or active vapor extraction to help prevent further contamination of groundwater. The CPT locations within the waste site were selected based on results frommore » previous shallow soil gas surveys, groundwater contamination data, and the suspected basin center. Geophysical data and soil gas samples were collected at twenty five locations and twenty five vadose zone wells were installed. The wells were screened to target the clay zones and areas of higher soil gas concentrations. The well construction diagrams are provided in Appendix B. Baro-Ball{trademark} valves for enhanced barometric pumping were installed on each well upon completion to immediately begin the remediation treatability study at the site.« less

  11. 76 FR 52656 - Lock+Hydro Friends Fund VII; Notice of Preliminary Permit Application Accepted for Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ... Friends Fund VII; Notice of Preliminary Permit Application Accepted for Filing and Soliciting Comments, Motions To Intervene, and Competing Applications On August 4, 2011, Lock+Hydro Friends Fund VII, filed an... Friends Fund VII, 5090 Richmond Avenue 390, Houston, TX 77056; phone (877) 556- 6566 x709. FERC Contact...

  12. 76 FR 79065 - Recordkeeping and Reporting Requirements Under Title VII, the ADA and GINA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-21

    ... DEPARTMENT OF LABOR Equal Employment Opportunity Commission 29 CFR Part 1602 Recordkeeping and Reporting Requirements Under Title VII, the ADA and GINA CFR Correction In Title 29 of the Code of Federal... title VII or section 107 of the ADA'' and add in their place the words ``section 709(c) of title VII...

  13. Type VII Collagen is Enriched in the Enamel Organic Matrix Associated with the Dentin-Enamel Junction of Mature Human Teeth

    PubMed Central

    McGuire, Jacob D.; Walker, Mary P.; Mousa, Ahmad; Wang, Yong; Gorski, Jeff P.

    2014-01-01

    The inner enamel region of erupted teeth is known to exhibit higher fracture toughness and crack growth resistance than bulk phase enamel. However, an explanation for this behavior has been hampered by the lack of compositional information for the residual enamel organic matrix. Since enamel-forming ameloblasts are known to express type VII collagen and type VII collagen null mice display abnormal amelogenesis, the aim of this study was to determine whether type VII collagen is a component of the enamel organic matrix at the dentin-enamel junction (DEJ) of mature human teeth. Immunofluorescent confocal microscopy of demineralized tooth sections localized type VII collagen to the organic matrix surrounding individual enamel rods near the DEJ. Morphologically, immunoreactive type VII collagen helical-bundles resembled the gnarled-pattern of enamel rods detected by Coomassie Blue staining. Western blotting of whole crown or enamel matrix extracts also identified characteristic Mr=280 and 230 kDa type VII dimeric forms, which resolved into 75 and 25 kDa bands upon reduction. As expected, the collagenous domain of type VII collagen was resistant to pepsin digestion, but was susceptible to purified bacterial collagenase. These results demonstrate the inner enamel organic matrix in mature teeth contains macromolecular type VII collagen. Based on its physical association with the DEJ and its well-appreciated capacity to complex with other collagens, we hypothesize that enamel embedded type VII collagen fibrils may contribute not only to the structural resilience of enamel, but may also play a role in bonding enamel to dentin. PMID:24594343

  14. Learning from history: the legacy of Title VII in academic family medicine.

    PubMed

    Newton, Warren; Arndt, Jane E

    2008-11-01

    The current renaissance of interest in primary care could benefit from reviewing the history of federal investment in academic family medicine. The authors review 30 years of experience with the Title VII, Section 747 Training in Primary Care Medicine and Dentistry (Title VII) grant program, addressing three questions: (1) What Title VII grant programs were available to family medicine, and what were their goals? (2) How did Title VII change the discipline? and (3) What impact did Title VII family medicine programs have outside the discipline?Title VII grant programs evolved from broad support for the new discipline of family medicine to a sharper focus on specific national workforce objectives such as improving care for underserved and vulnerable populations and increasing diversity in the health professions. Grant programs were instrumental in establishing family medicine in nearly all medical schools and in supporting the educational underpinnings of the field. Title VII grants helped enhance the social capital of the discipline. Outside family medicine, Title VII fostered the development of innovative ambulatory education, institutional initiatives focusing on underserved and vulnerable populations, and primary care research capacity. Adverse effects include relative inattention to clinical and research missions in family medicine academic units and, institutionally, the development of medical education initiatives without core institutional support, which has put innovation and extension of education to communities at risk as grant funding has decreased. Reinvestment in academic family medicine can yield substantial benefits for family medicine and help reorient academic health centers. This article is part of a theme issue of Academic Medicine on the Title VII health professions training programs.

  15. Oxidation of Microcystins by Permanganate: pH and Temperature-Dependent Kinetics, Effect of DOM Characteristics, and Oxidation Mechanism Revisited.

    PubMed

    Kim, Min Sik; Lee, Hye-Jin; Lee, Ki-Myeong; Seo, Jiwon; Lee, Changha

    2018-05-23

    Oxidative degradation of six representative microcystins (MCs) (MC-RR, -LR, -YR, -LF, -LW and -LA) by potassium permanganate (KMnO4; Mn(VII)) was investigated, focusing on the temperature- and pH-dependent reaction kinetics, the effect of dissolved organic matter (DOM), and the oxidation mechanisms. Second-order rate constants for the reactions of the six MCs with Mn(VII) (kMn(VII),MC) were determined to be 160.4-520.1 M-1 s-1 (MC-RR > -LR  -YR > -LF  -LW > -LA) at pH 7.2 and 21°C. The kMn(VII),MC values exhibited activation energies ranging from 15.1 to 22.4 kJ mol-1. With increasing pH from 2 to 11, the kMn(VII),MC values decreased until pH 5, and plateaued over the pH range of 5-11, except for that of MC-YR (which increased at pH > 8). Species-specific second-order rate constants were calculated using predicted pKa values of MCs. The oxidation of MCs in natural waters was accurately predicted by the kinetic model using kMn(VII),MC and Mn(VII) exposure ([Mn(VII)]dt) values. Among different characteristics of DOM in natural waters, UV254, SUVA254, and the abundance of humic-like substances characterized by fluorescence spectroscopy exhibited good correlation with [Mn(VII)]dt. A thorough product study of MC-LR oxidation by Mn(VII) was performed using liquid chromatography-mass spectrometry.

  16. Quantitative analysis of the synthesis and secretion of type VII collagen in cultured human dermal fibroblasts with a sensitive sandwich enzyme-linked immunoassay.

    PubMed

    Amano, Satoshi; Ogura, Yuki; Akutsu, Nobuko; Nishiyama, Toshio

    2007-02-01

    Type VII collagen is the major component of anchoring fibrils in the epidermal basement membrane. Its expression has been analyzed by immunostaining or Northern blotting, but rarely at the protein level. In this study, we have quantitatively examined the effects of ascorbic acid and various cytokines/growth factors on the protein synthesis and secretion of type VII collagen by human dermal fibroblasts in culture, using a developed, highly sensitive sandwich enzyme-linked immunoassay with two kinds of specific monoclonal antibodies against the non-collagenous domain-1. Ascorbic acid and its derivative induced a twofold increase in type VII collagen synthesis, and markedly increased the secretion of type VII collagen into the medium when compared with the control culture. This effect was not influenced by the presence of transforming growth factor-beta1 (TGF-beta1). The synthesis of type VII collagen was elevated by TGF-beta1, platelet-derived growth factor, tumor necrosis factor-alpha, and interleukin-1beta, but not by TGF-alpha. Thus, our data indicate that the synthesis and secretion of type VII collagen in human dermal fibroblasts are regulated by ascorbate and the enhancement of type VII collagen gene expression by cytokines/growth factors is accompanied with elevated production of type VII collagen at the protein level.

  17. Enhanced functional recombinant factor VII production by HEK 293 cells stably transfected with VKORC1 where the gamma-carboxylase inhibitor calumenin is stably suppressed by shRNA transfection.

    PubMed

    Wajih, Nadeem; Owen, John; Wallin, Reidar

    2008-01-01

    Recombinant members of the vitamin K-dependent protein family (factors IX and VII and protein C) have become important pharmaceuticals in treatment of bleeding disorders and sepsis. However, because the in vivo gamma-carboxylation system in stable cell lines used for transfection has a limited capacity of post translational gamma-carboxylation, the recovery of fully gamma-carboxylated and functional proteins is low. In this work we have engineered recombinant factor VII producing HEK 293 cells to stably overexpress VKORC1, the reduced vitamin K gamma-carboxylase cofactor and in addition stably silenced the gamma-carboxylase inhibitory protein calumenin. Stable cell lines transfected with only a factor VII cDNA had a 9% production of functional recombinant factor VII. On the other hand, these recombinant factor VII producing cells when engineered to overexpress VKORC1 and having calumenin stably suppressed more than 80% by shRNA expression, produced 68% functional factor VII. The technology presented should be applicable to all vertebrae members of the vitamin K-dependent protein family and should lower the production cost of the clinically used factors VII, IX and protein C.

  18. Structural incorporation of MgCl2 into ice VII at room temperature

    NASA Astrophysics Data System (ADS)

    Watanabe, Mao; Komatsu, Kazuki; Noritake, Fumiya; Kagi, Hiroyuki

    2017-05-01

    Raman spectra and X-ray diffraction patterns were obtained from 1:100 and 1:200 \\text{MgCl}2:\\text{H}2\\text{O} solutions (in molar ratio) at pressures up to 6 GPa using diamond anvil cells (DACs) and compared with those of pure water. The O-H stretching band from ice VII crystallized from the 1:200 solution was approximately 10 cm-1 higher than that of pure ice VII. The phase boundaries between ice VII and VIII crystallized from the MgCl2 solutions at 4 GPa were 2 K lower than those of pure ice VII and VIII. These observations indicate that ice VII incorporates MgCl2 into its structure. The unit cell volumes of ice VII crystallized from pure water and the two solutions coincided with each other within the experimental error, and salt incorporation was not detectable from the cell volume. Possible configurations of ion substitution and excess volume of ice VIII were simulated on the basis of density functional theory (DFT) calculations.

  19. 15 CFR Appendix B to Subpart M of... - Zones Within the Sanctuary Where Overflights Below 1000 Feet Are Prohibited

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... high water to 3 nautical miles (nmi) offshore between a line extending from Point Santa Cruz on a southwesterly bearing of 220° true and a line extending from 2.0 nmi north of Pescadero Point on a southwesterly bearing of 240° true; (2) From mean high water to 3 nmi offshore between a line extending from the Carmel...

  20. 15 CFR Appendix B to Subpart M of... - Zones Within the Sanctuary Where Overflights Below 1000 Feet Are Prohibited

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... high water to 3 nautical miles (nmi) offshore between a line extending from Point Santa Cruz on a southwesterly bearing of 220° true and a line extending from 2.0 nmi north of Pescadero Point on a southwesterly bearing of 240° true; (2) From mean high water to 3 nmi offshore between a line extending from the Carmel...

  1. 15 CFR Appendix B to Subpart M of... - Zones Within the Sanctuary Where Overflights Below 1000 Feet Are Prohibited

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... high water to 3 nautical miles (nmi) offshore between a line extending from Point Santa Cruz on a southwesterly bearing of 220° true and a line extending from 2.0 nmi north of Pescadero Point on a southwesterly bearing of 240° true; (2) From mean high water to 3 nmi offshore between a line extending from the Carmel...

  2. Geophysical investigation of seamounts near the Ogasawara Fracture Zone, western Pacific

    NASA Astrophysics Data System (ADS)

    Lee, T.-G.; Lee, K.; Hein, J. R.; Moon, J.-W.

    2009-03-01

    This paper provides an analysis of multi-channel seismic data obtained during 2000-2001 on seamounts near the Ogasawara Fracture Zone (OFZ) northwest of the Marshall Islands in the western Pacific. The OFZ is unique in that it is a wide rift zone that includes many seamounts. Seven units are delineated on the basis of acoustic characteristics and depth: three units (I, II, and III) on the summit of seamounts and four units (IV, V, VI, and VII) in basins. Acoustic characteristics of layers on the summit of guyots and dredged samples indicate that the seamounts had been built above sea level by volcanism. This was followed by reef growth along the summit margin, which enabled deposition of shallow-water carbonates on the summit, and finally by subsidence of the edifices. The subsidence depth of the seamounts, estimated from the lower boundary of unit II, ranges between 1,550 and 2,040 m. The thick unit I of the southern seamounts is correlated with proximity to the equatorial high productivity zone, whereas local currents may have strongly affected the distribution of unit I on northern seamounts. A seismic profile in the basin around the Ita Mai Tai and OSM4 seamounts shows an unconformity between units IV and V, which is widespread from the East Mariana Basin to the Pigafetta Basin.

  3. Low-temperature overpressurization protection system setpoint analysis using RETRAN-02/MOD5 for Salem

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dodson, R.J.; Feltus, M.A.

    The low-temperature overpressurization protection system (LTOPS) is designed to protect the reactor pressure vessel (RPV) from brittle failure during startup and cooldown maneuvers in Westinghouse pressurized water reactors. For the Salem power plants, the power-operated relief valves (PORVs) mitigate pressure increases above a setpoint where an operational startup transient may put the RPV in the embrittlement fracture zone. The Title 10, Part 50, Code of Federal Regulations Appendix G limit, given by plant technical specifications, conservatively bounds the maximum pressure allowed during those transients where the RPV can suffer brittle fracture (usually below 350{degrees}F). The Appendix G limit is amore » pressure versus temperature curve that is more restrictive at lower RPV temperatures and allows for higher pressures as the temperature approaches the upper bounding fracture temperature.« less

  4. Evolving Service Roles in Presence Missions,

    DTIC Science & Technology

    1995-08-01

    Service chronology of discrete presence incidents for the period from the beginning of the end of the Cold War (1983) through late 1994. Six detailed...Discussion Vi-8 VI VII. OBSERVATIONS AND RECOMMENDATIONS VII-1 A. Observations VII-1 B. Recommendations VII-2 APPENDICES A. Chronology of...great value in improving understanding between nations, it also seems extremely unlikely that such activities could substitute for well- trained

  5. Delayed hypertrophic differentiation of epiphyseal chondrocytes contributes to failed secondary ossification in mucopolysaccharidosis VII dogs

    PubMed Central

    Peck, Sun H.; O'Donnell, Philip J.M.; Kang, Jennifer L.; Malhotra, Neil R.; Dodge, George R.; Pacifici, Maurizio; Shore, Eileen M.; Haskins, Mark E.; Smith, Lachlan J.

    2015-01-01

    Mucopolysaccharidosis (MPS) VII is a lysosomal storage disorder characterized by deficient β-glucuronidase activity, which leads to the accumulation of incompletely degraded glycosaminoglycans (GAGs). MPS VII patients present with severe skeletal abnormalities, which are particularly prevalent in the spine. Incomplete cartilage-to-bone conversion in MPS VII vertebrae during postnatal development is associated with progressive spinal deformity and spinal cord compression. The objectives of this study were to determine the earliest postnatal developmental stage at which vertebral bone disease manifests in MPS VII and to identify the underlying cellular basis of impaired cartilage-to-bone conversion, using the naturally-occurring canine model. Control and MPS VII dogs were euthanized at 9 and 14 days-of-age, and vertebral secondary ossification centers analyzed using micro-computed tomography, histology, qPCR, and protein immunoblotting. Imaging studies and mRNA analysis of bone formation markers established that secondary ossification commences between 9 and 14 days in control animals, but not in MPS VII animals. mRNA analysis of differentiation markers revealed that MPS VII epiphyseal chondrocytes are unable to successfully transition from proliferation to hypertrophy during this critical developmental window. Immunoblotting demonstrated abnormal persistence of Sox9 protein in MPS VII cells between 9 and 14 days-of-age, and biochemical assays revealed abnormally high intra and extracellular GAG content in MPS VII epiphyseal cartilage at as early as 9 days-of-age. In contrast, assessment of vertebral growth plates and primary ossification centers revealed no significant abnormalities at either age. The results of this study establish that failed vertebral bone formation in MPS VII can be traced to the failure of epiphyseal chondrocytes to undergo hypertrophic differentiation at the appropriate developmental stage, and suggest that aberrant processing of Sox9 protein may contribute to this cellular dysfunction. These results also highlight the importance of early diagnosis and therapeutic intervention to prevent the progression of debilitating skeletal disease in MPS patients. PMID:26422116

  6. Type VII collagen is enriched in the enamel organic matrix associated with the dentin-enamel junction of mature human teeth.

    PubMed

    McGuire, Jacob D; Walker, Mary P; Mousa, Ahmad; Wang, Yong; Gorski, Jeff P

    2014-06-01

    The inner enamel region of erupted teeth is known to exhibit higher fracture toughness and crack growth resistance than bulk phase enamel. However, an explanation for this behavior has been hampered by the lack of compositional information for the residual enamel organic matrix. Since enamel-forming ameloblasts are known to express type VII collagen and type VII collagen null mice display abnormal amelogenesis, the aim of this study was to determine whether type VII collagen is a component of the enamel organic matrix at the dentin-enamel junction (DEJ) of mature human teeth. Immunofluorescent confocal microscopy of demineralized tooth sections localized type VII collagen to the organic matrix surrounding individual enamel rods near the DEJ. Morphologically, immunoreactive type VII collagen helical-bundles resembled the gnarled-pattern of enamel rods detected by Coomassie Blue staining. Western blotting of whole crown or enamel matrix extracts also identified characteristic Mr=280 and 230 kDa type VII dimeric forms, which resolved into 75 and 25 kDa bands upon reduction. As expected, the collagenous domain of type VII collagen was resistant to pepsin digestion, but was susceptible to purified bacterial collagenase. These results demonstrate the inner enamel organic matrix in mature teeth contains macromolecular type VII collagen. Based on its physical association with the DEJ and its well-appreciated capacity to complex with other collagens, we hypothesize that enamel embedded type VII collagen fibrils may contribute not only to the structural resilience of enamel, but may also play a role in bonding enamel to dentin. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Pathogenesis of lumbar spine disease in mucopolysaccharidosis VII

    PubMed Central

    Smith, Lachlan J; Baldo, Guilherme; Wu, Susan; Liu, Yuli; Whyte, Michael P; Giugliani, Roberto; Elliott, Dawn M; Haskins, Mark E; Ponder, Katherine P

    2012-01-01

    Mucopolysaccharidosis type VII (MPS VII) is characterized by deficient β-glucuronidase (GUSB) activity, which leads to accumulation of chondroitin, heparan and dermatan sulfate glycosaminoglycans (GAGs), and multisystemic disease. MPS VII patients can develop kypho-scoliotic deformity and spinal cord compression due to disease of intervertebral discs, vertebral bodies, and associated tissues. We have previously demonstrated in MPS VII dogs that intervertebral discs degenerate, vertebral bodies have irregular surfaces, and vertebral body epiphyses have reduced calcification, but the pathophysiological mechanisms underlying these changes are unclear. We hypothesized that some of these manifestations could be due to upregulation of destructive proteases, possibly via the binding of GAGs to Toll-like receptor 4 (TLR4), as has been proposed for other tissues in MPS models. In this study, the annulus fibrosus of the intervertebral disc of 6 month-old MPS VII dogs had cathepsin B and K activities that were 117- and 2-fold normal, respectively, which were associated with elevations in mRNA levels for cathepsins as well as TLR4. The epiphyses of MPS VII dogs had a marked elevation in mRNA for the cartilage-associated gene collagen II, consistent with a developmental delay in the conversion of the cartilage to bone in this region. A spine from a human patient with MPS VII exhibited similar increased cartilage in the vertebral bodies adjacent to the end plates, disorganization of the intervertebral discs, and irregular vertebral end plate morphology. These data suggest that the pathogenesis of destructive changes in the spine in MPS VII may involve upregulation of cathepsins. Inhibition of destructive proteases, such as cathepsins, might reduce spine disease in patients with MPS VII or related disorders. PMID:22513347

  8. Gentamicin induces functional type VII collagen in recessive dystrophic epidermolysis bullosa patients

    PubMed Central

    Woodley, David T.; Cogan, Jon; Hou, Yingping; Lyu, Chao; Marinkovich, M. Peter; Keene, Douglas

    2017-01-01

    BACKGROUND. Recessive dystrophic epidermolysis bullosa (RDEB) is an incurable disease caused by mutations in the gene encoding type VII collagen, the major component of anchoring fibrils (AF). We previously demonstrated that gentamicin produced functional type VII collagen in RDEB cells harboring nonsense mutations. Herein, we determined whether topical or intradermal gentamicin administration induces type VII collagen and AFs in RDEB patients. METHODS. A double-blind, placebo-controlled pilot trial assessed safety and efficacy of topical and intradermal gentamicin in 5 RDEB patients with nonsense mutations. The topical arm tested 0.1% gentamicin ointment or placebo application 3 times daily at 2 open erosion sites for 2 weeks. The intradermal arm tested daily intradermal injection of gentamicin solution (8 mg) or placebo into 2 intact skin sites for 2 days in 4 of 5 patients. Primary outcomes were induction of type VII collagen and AFs at the test sites and safety assessment. A secondary outcome assessed wound closure of topically treated erosions. RESULTS. Both topical and intradermal gentamicin administration induced type VII collagen and AFs at the dermal-epidermal junction of treatment sites. Newly created type VII collagen varied from 20% to 165% of that expressed in normal human skin and persisted for 3 months. Topical gentamicin corrected dermal-epidermal separation, improved wound closure, and reduced blister formation. There were no untoward side effects from gentamicin treatments. Type VII collagen induction did not generate anti–type VII collagen autoantibodies in patients’ blood or skin. CONCLUSION. Topical and intradermal gentamicin suppresses nonsense mutations and induces type VII collagen and AFs in RDEB patients. Gentamicin therapy may provide a readily available treatment for RDEB patients with nonsense mutations. TRIAL REGISTRATION. ClinicalTrials.gov NCT02698735. FUNDING. Epidermolysis Bullosa Research Partnership, Epidermolysis Bullosa Medical Research Foundation, NIH, and VA Merit Award. PMID:28691931

  9. Pseudane-VII Isolated from Pseudoalteromonas sp. M2 Ameliorates LPS-Induced Inflammatory Response In Vitro and In Vivo

    PubMed Central

    Kim, Mi Eun; Jung, Inae; Na, Ju Yong; Kim, Woo Jung; Kim, Young-Ok; Park, Yong-Duk; Lee, Jun Sik

    2017-01-01

    The ocean is a rich resource of flora, fauna, food, and biological products. We found a wild-type bacterial strain, Pseudoalteromonas sp. M2, from marine water and isolated various secondary metabolites. Pseudane-VII is a compound isolated from the Pseudoalteromonas sp. M2 metabolite that possesses anti-melanogenic activity. Inflammation is a response of the innate immune system to microbial infections. Macrophages have a critical role in fighting microbial infections and inflammation. Recent studies reported that various compounds derived from natural products can regulate immune responses including inflammation. However, the anti-inflammatory effects and mechanism of pseudane-VII in macrophages are still unknown. In this study, we investigated the anti-inflammatory effects of pseudane-VII. In present study, lipopolysaccharide (LPS)-induced nitric oxide (NO) production was significantly decreased by pseudane-VII treatment at 6 μM. Moreover, pseudane-VII treatment dose-dependently reduced mRNA levels of pro-inflammatory cytokines including inos, cox-2, il-1β, tnf-α, and il-6 in LPS-stimulated macrophages. Pseudane-VII also diminished iNOS protein levels and IL-1β secretion. In addition, Pseudane-VII elicited anti-inflammatory effects by inhibiting ERK, JNK, p38, and nuclear factor (NF)-κB-p65 phosphorylation. Consistently, pseudane-VII was also shown to inhibit the LPS-stimulated release of IL-1β and expression of iNOS in mice. These results suggest that pseudane-VII exerted anti-inflammatory effects on LPS-stimulated macrophage activation via inhibition of ERK, JNK, p38 MAPK phosphorylation, and pro-inflammatory gene expression. These findings may provide new approaches in the effort to develop anti-inflammatory therapeutics. PMID:29104209

  10. Pseudane-VII Isolated from Pseudoalteromonas sp. M2 Ameliorates LPS-Induced Inflammatory Response In Vitro and In Vivo.

    PubMed

    Kim, Mi Eun; Jung, Inae; Lee, Jong Suk; Na, Ju Yong; Kim, Woo Jung; Kim, Young-Ok; Park, Yong-Duk; Lee, Jun Sik

    2017-11-01

    The ocean is a rich resource of flora, fauna, food, and biological products. We found a wild-type bacterial strain, Pseudoalteromonas sp. M2, from marine water and isolated various secondary metabolites. Pseudane-VII is a compound isolated from the Pseudoalteromonas sp. M2 metabolite that possesses anti-melanogenic activity. Inflammation is a response of the innate immune system to microbial infections. Macrophages have a critical role in fighting microbial infections and inflammation. Recent studies reported that various compounds derived from natural products can regulate immune responses including inflammation. However, the anti-inflammatory effects and mechanism of pseudane-VII in macrophages are still unknown. In this study, we investigated the anti-inflammatory effects of pseudane-VII. In present study, lipopolysaccharide (LPS)-induced nitric oxide (NO) production was significantly decreased by pseudane-VII treatment at 6 μM. Moreover, pseudane-VII treatment dose-dependently reduced mRNA levels of pro-inflammatory cytokines including inos , cox-2 , il-1β , tnf-α , and il-6 in LPS-stimulated macrophages. Pseudane-VII also diminished iNOS protein levels and IL-1β secretion. In addition, Pseudane-VII elicited anti-inflammatory effects by inhibiting ERK, JNK, p38, and nuclear factor (NF)-κB-p65 phosphorylation. Consistently, pseudane-VII was also shown to inhibit the LPS-stimulated release of IL-1β and expression of iNOS in mice. These results suggest that pseudane-VII exerted anti-inflammatory effects on LPS-stimulated macrophage activation via inhibition of ERK, JNK, p38 MAPK phosphorylation, and pro-inflammatory gene expression. These findings may provide new approaches in the effort to develop anti-inflammatory therapeutics.

  11. [Coagulation factor VII levels in uremic patients and theirs influence factors].

    PubMed

    Fang, Jun; Xia, Ling-Hui; Wei, Wen-Ning; Song, Shan-Jun

    2004-12-01

    This study was aimed to investigate coagulation factor VII level in uremic patients with chronic renal failure and to explore theirs influence factors. The plasma levels of coagulation factor VII were detected in 30 uremic patients with chronic renal failure before and after hemodialysis for 1 month, the factor VII activity (FVII:C) was determined by one-stage coagulation method, while activated factor VII (FVIIa) was measured by one-stage coagulation method using recombinant soluble tissue factor, and factor VII antigen was detected by ELISA. The results showed that: (1) The FVIIa, FVII:C and FVIIAg levels in chronic uremic patients before hemodialysis were 4.00 +/- 0.86 microg/L, (148.5 +/- 40.4)% and (99.8 +/- 21.1)% respectively, which were significantly increased, as compared with healthy controls [2.77 +/- 1.02 microg/L, (113.1 +/- 33.0)% and (73.7 +/- 18.3)% respectively, P < 0.05]. (2) After hemodialysis the FVIIa, FVII:C and FVIIAg levels in uremic patients significantly enhanced to 5.56 +/- 1.45 microg/L, (200.8 +/- 68.7)% and (124.1 +/- 19.3)% respectively (P < 0.05). (3) The abnormal increase of coagulation factor VII was positively correlated with levels of blood uria nitrogen and serum creatinine before hemodialysis but not after hemodialysis. It is concluded that the enhanced levels of coagulation factor VII in chronic uremic patients suggested abnormal activated state, herperactivity and elevated production of factor VII which correlated with renal functional injury. The abnormality of factor VII in uremia may be aggravated by hemodialysis. Coagulation factor (FVII) may be a risk factor for cardiovascular events in uremic patients who especially had been accepted long-term hemodialysis.

  12. Expanding the versatility of phage display II: improved affinity selection of folded domains on protein VII and IX of the filamentous phage.

    PubMed

    Løset, Geir Åge; Roos, Norbert; Bogen, Bjarne; Sandlie, Inger

    2011-02-24

    Phage display is a leading technology for selection of binders with affinity for specific target molecules. Polypeptides are normally displayed as fusions to the major coat protein VIII (pVIII) or the minor coat protein III (pIII). Whereas pVIII display suffers from drawbacks such as heterogeneity in display levels and polypeptide fusion size limitations, toxicity and infection interference effects have been described for pIII display. Thus, display on other coat proteins such as pVII or pIX might be more attractive. Neither pVII nor pIX display have gained widespread use or been characterized in detail like pIII and pVIII display. Here we present a side-by-side comparison of display on pIII with display on pVII and pIX. Polypeptides of interest (POIs) are fused to pVII or pIX. The N-terminal periplasmic signal sequence, which is required for phage integration of pIII and pVIII and that has been added to pVII and pIX in earlier studies, is omitted altogether. Although the POI display level on pIII is higher than on pVII and pIX, affinity selection with pVII and pIX display libraries is shown to be particularly efficient. Display through pVII and/or pIX represent platforms with characteristics that differ from those of the pIII platform. We have explored this to increase the performance and expand the use of phage display. In the paper, we describe effective affinity selection of folded domains displayed on pVII or pIX. This makes both platforms more attractive alternatives to conventional pIII and pVIII display than they were before.

  13. Enhanced Functional Recombinant Factor VII Production by HEK 293 Cells Stably Transfected with VKORC1 where the Gamma-Carboxylase Inhibitor Calumenin is Stably Suppressed by shRNA Transfection

    PubMed Central

    Wajih, Nadeem; Owen, John; Wallin, Reidar

    2008-01-01

    Introduction Recombinant members of the vitamin K-dependent protein family (factors IX and VII and protein C) have become important pharmaceuticals in treatment of bleeding disorders and sepsis. However, because the in vivo γ-carboxylation system in stable cell lines used for transfection has a limited capacity of post translational γ carboxylation, the recovery of fully γ-carboxylated and functional proteins is low. Materials and Methods In this work we have engineered recombinant factor VII producing HEK 293 cells to stably overexpress VKORC1, the reduced vitamin K γ-carboxylase cofactor and in addition stably silenced the γ-carboxylase inhibitory protein calumenin. Results and Conclusions Stable cell lines transfected with only a factor VII cDNA had a 9% production of functional recombinant factor VII. On the other hand, these recombinant factor VII producing cells when engineered to overexpress VKORC1 and having calumenin stably suppressed more than 80% by shRNA expression, produced 68% functional factor VII. The technology presented should be applicable to all vertebrae members of the vitamin K-dependent protein family and should lower the production cost of the clinically used factors VII, IX and protein C. PMID:18177690

  14. (99)Tc(VII) Retardation, Reduction, and Redox Rate Scaling in Naturally Reduced Sediments.

    PubMed

    Liu, Yuanyuan; Liu, Chongxuan; Kukkadapu, Ravi K; McKinley, James P; Zachara, John; Plymale, Andrew E; Miller, Micah D; Varga, Tamas; Resch, Charles T

    2015-11-17

    An experimental and modeling study was conducted to investigate pertechnetate (Tc(VII)O4(-)) retardation, reduction, and rate scaling in three sediments from Ringold formation at U.S. Department of Energy's Hanford site, where (99)Tc is a major contaminant in groundwater. Tc(VII) was reduced in all the sediments in both batch reactors and diffusion columns, with a faster rate in a sediment containing a higher concentration of HCl-extractable Fe(II). Tc(VII) migration in the diffusion columns was reductively retarded with retardation degrees correlated with Tc(VII) reduction rates. The reduction rates were faster in the diffusion columns than those in the batch reactors, apparently influenced by the spatial distribution of redox-reactive minerals along transport paths that supplied Tc(VII). X-ray computed tomography and autoradiography were performed to identify the spatial locations of Tc(VII) reduction and transport paths in the sediments, and results generally confirmed the newly found behavior of reaction rate changes from batch to column. The results from this study implied that Tc(VII) migration can be reductively retarded at Hanford site with a retardation degree dependent on reactive Fe(II) content and its distribution in sediments. This study also demonstrated that an effective reaction rate may be faster in transport systems than that in well-mixed reactors.

  15. Heptavalent Actinide Tetroxides NpO 4 – and PuO 4 –: Oxidation of Pu(V) to Pu(VII) by Adding an Electron to PuO 4

    DOE PAGES

    Gibson, John K.; de Jong, Wibe A.; Dau, Phuong D.; ...

    2017-11-14

    The highest known actinide oxidation states are Np(VII) and Pu(VII), both of which have been identified in solution and solid compounds. Recently a molecular Np(VII) complex, NpO 3(NO 3) 2-, was prepared and characterized in the gas phase. In accord with the lower stability of heptavalent Pu, no Pu(VII) molecular species has been identified. Reported here are the gas-phase syntheses and characterizations of NpO 4 - and PuO 4 -. Reactivity studies and density functional theory computations indicate the heptavalent metal oxidation state in both. This is the first instance of Pu(VII) in the absence of stabilizing effects due tomore » condensed phase solvation or crystal fields. Here, the results indicate that addition of an electron to neutral PuO 4, which has a computed electron affinity of 2.56 eV, counterintuitively results in oxidation of Pu(V) to Pu(VII), concomitant with superoxide reduction.« less

  16. Heptavalent Actinide Tetroxides NpO 4 – and PuO 4 –: Oxidation of Pu(V) to Pu(VII) by Adding an Electron to PuO 4

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gibson, John K.; de Jong, Wibe A.; Dau, Phuong D.

    The highest known actinide oxidation states are Np(VII) and Pu(VII), both of which have been identified in solution and solid compounds. Recently a molecular Np(VII) complex, NpO 3(NO 3) 2-, was prepared and characterized in the gas phase. In accord with the lower stability of heptavalent Pu, no Pu(VII) molecular species has been identified. Reported here are the gas-phase syntheses and characterizations of NpO 4 - and PuO 4 -. Reactivity studies and density functional theory computations indicate the heptavalent metal oxidation state in both. This is the first instance of Pu(VII) in the absence of stabilizing effects due tomore » condensed phase solvation or crystal fields. Here, the results indicate that addition of an electron to neutral PuO 4, which has a computed electron affinity of 2.56 eV, counterintuitively results in oxidation of Pu(V) to Pu(VII), concomitant with superoxide reduction.« less

  17. Synergetic Action of Domain II and IV Underlies Persistent Current Generation in Nav1.3 as revealed by a tarantula toxin

    PubMed Central

    Tang, Cheng; Zhou, Xi; Zhang, Yunxiao; xiao, Zhaohua; Hu, Zhaotun; Zhang, Changxin; Huang, Ying; Chen, Bo; Liu, Zhonghua; Liang, Songping

    2015-01-01

    The persistent current (INaP) through voltage-gated sodium channels enhances neuronal excitability by causing prolonged depolarization of membranes. Nav1.3 intrinsically generates a small INaP, although the mechanism underlying its generation remains unclear. In this study, the involvement of the four domains of Nav1.3 in INaP generation was investigated using the tarantula toxin α-hexatoxin-MrVII (RTX-VII). RTX-VII activated Nav1.3 and induced a large INaP. A pre-activated state binding model was proposed to explain the kinetics of toxin-channel interaction. Of the four domains of Nav1.3, both domain II and IV might play important roles in the toxin-induced INaP. Domain IV constructed the binding site for RTX-VII, while domain II might not participate in interacting with RTX-VII but could determine the efficacy of RTX-VII. Our results based on the use of RTX-VII as a probe suggest that domain II and IV cooperatively contribute to the generation of INaP in Nav1.3. PMID:25784299

  18. Experimental evidence for competitive growth advantage of genotype VII over VI: implications for foot-and-mouth disease virus serotype A genotype turnover in nature.

    PubMed

    Mohapatra, J K; Subramaniam, S; Singh, N K; Sanyal, A; Pattnaik, B

    2012-04-01

    In India, systematic genotype replacement has been observed for serotype A foot-and-mouth disease virus. After a decade of co-circulation of genotypes VI and VII, genotype VII emerged as the single dominant genotype since 2001. To derive possible explanations for such epochal evolution dynamics, in vitro intergenotype growth competition experiments involving both co- and superinfection regimes were conducted. Coinfection of BHK-21 cells demonstrated abrupt loss in the genotype VI viral load with commensurate increase in the load of genotype VII as measured by the genotype differentiating ELISA, RT-PCR and real-time RT-PCR. The superinfection dynamics was shaped by temporal spacing of infection, where the invading genotype VII took more number of passages than coinfection to eventually overtake the resident genotype VI. It was speculated that such superior replicative fitness of genotype VII could have been a possible factor for the ultimate dominance of genotype VII in nature. Copyright © 2011 Elsevier Ltd. All rights reserved.

  19. Effects of the Application of the New Nuclear Data Library ENDF/B to the Criticality Analysis of AP1000

    NASA Astrophysics Data System (ADS)

    Kuntoro, Iman; Sembiring, T. M.; Susilo, Jati; Deswandri; Sunaryo, G. R.

    2018-02-01

    Calculations of criticality of the AP1000 core due to the use of new edition of nuclear data library namely ENDF/B-VII and ENDF/B-VII.1 have been done. This work is aimed to know the accuracy of ENDF/B-VII.1 compared to ENDF/B-VII and ENDF/B-VI.8. in determining the criticality parameter of AP1000. Analysis ws imposed to core at cold zero power (CZP) conditions. The calculations have been carried out by means of MCNP computer code for 3 dimension geometry. The results show that criticality parameter namely effective multiplication factor of the AP1000 core are higher than that ones resulted from ENDF/B-VI.8 with relative differences of 0.39% for application of ENDF/B-VII and of 0.34% for application of ENDF/B-VII.1.

  20. Antimicrobial peptide scolopendrasin VII, derived from the centipede Scolopendra subspinipes mutilans, stimulates macrophage chemotaxis via formyl peptide receptor 1

    PubMed Central

    Park, Yoo Jung; Lee, Ha Young; Jung, Young Su; Park, Joon Seong; Hwang, Jae Sam; Bae, Yoe-Sik

    2015-01-01

    In this study, we report that one of the antimicrobial peptides scolopendrasin VII, derived from Scolopendra subspinipes mutilans, stimulates actin polymerization and the subsequent chemotactic migration of macrophages through the activation of ERK and protein kinase B (Akt) activity. The scolopendrasin VII-induced chemotactic migration of macrophages is inhibited by the formyl peptide receptor 1 (FPR1) antagonist cyclosporine H. We also found that scolopendrasin VII stimulate the chemotactic migration of FPR1-transfected RBL-2H3 cells, but not that of vector-transfected cells; moreover, scolopendrasin VII directly binds to FPR1. Our findings therefore suggest that the antimicrobial peptide scolopendrasin VII, derived from Scolopendra subspinipes mutilans, stimulates macrophages, resulting in chemotactic migration via FPR1 signaling, and the peptide can be useful in the study of FPR1-related biological responses. [BMB Reports 2015; 48(8): 479-484] PMID:26129676

  1. Gulf Coast Deep Water Port Facilities study. Appendix B. North Central Gulf Hydrobiological Zones.

    DTIC Science & Technology

    1973-04-01

    bottom and surface salinities , but their effect is more noticeable at the surface. Because of variation in these factors along the Gulf Coast... effects of discharge on salinity have been considered above. Numerous streams empty into the Gulf of Mexico along its north central portion but the...1967) investigated various aspects of osmoregulation in blue crabs in Mississippi Sound and adjacent waters and observed that salinity and temperature

  2. A Generalized Method for Vertical Profiles of Mean Layer Values of Meteorological Variables

    DTIC Science & Technology

    2015-09-01

    NUMBER OF PAGES 62 19a. NAME OF RESPONSIBLE PERSON James Cogan a. REPORT Unclassified b. ABSTRACT Unclassified c . THIS PAGE...Message Zones, Primary Data Structure, and Sample METB3 Weighting Array 35 Appendix C . Samples of Input and Output 41 List of Symbols...39 Table C -1 Example of RAOB for Albuquerque, New Mexico. The first 3 mandatory levels are below the actual terrain surface and

  3. Joint Services Electronics Program. Appendix

    DTIC Science & Technology

    1992-11-01

    the accu- clude surface waves, creeping waves, multiple racy, convergence, and CPU times for the MM diffractions, shadowing effects , etc. A second ad...Method which is an approximation to the true current J Jn= A /m on the strip. The next section will discuss the - computation of the far zone...to the cavity (0 part of the incident plane wave captured by interior E•,. After a background discussion of the aperture at the open end is divided

  4. 40 CFR Appendix A to Subpart IIIi... - Determination of Capture Efficiency of Automobile and Light-Duty Truck Spray Booth Emissions From...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... coating, i. 2.5.1You must weigh the blank panel. (Same as in bake oven panel test.) The mass of the blank... spray booth zones being tested. (Different than bake oven panel test.) This weighing must be conducted... and before the bake oven where the coating applied to the panel is cured, 2.5.5.2All of the flash-off...

  5. 40 CFR Appendix A to Subpart IIIi... - Determination of Capture Efficiency of Automobile and Light-Duty Truck Spray Booth Emissions From...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... coating, i. 2.5.1You must weigh the blank panel. (Same as in bake oven panel test.) The mass of the blank... spray booth zones being tested. (Different than bake oven panel test.) This weighing must be conducted... and before the bake oven where the coating applied to the panel is cured, 2.5.5.2All of the flash-off...

  6. 40 CFR Appendix A to Subpart IIIi... - Determination of Capture Efficiency of Automobile and Light-Duty Truck Spray Booth Emissions From...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... coating, i. 2.5.1You must weigh the blank panel. (Same as in bake oven panel test.) The mass of the blank... spray booth zones being tested. (Different than bake oven panel test.) This weighing must be conducted... and before the bake oven where the coating applied to the panel is cured, 2.5.5.2All of the flash-off...

  7. 40 CFR Appendix A to Subpart IIIi... - Determination of Capture Efficiency of Automobile and Light-Duty Truck Spray Booth Emissions From...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... coating, i. 2.5.1You must weigh the blank panel. (Same as in bake oven panel test.) The mass of the blank... spray booth zones being tested. (Different than bake oven panel test.) This weighing must be conducted... and before the bake oven where the coating applied to the panel is cured, 2.5.5.2All of the flash-off...

  8. 40 CFR Appendix A to Subpart IIIi... - Determination of Capture Efficiency of Automobile and Light-Duty Truck Spray Booth Emissions From...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... coating, i. 2.5.1You must weigh the blank panel. (Same as in bake oven panel test.) The mass of the blank... spray booth zones being tested. (Different than bake oven panel test.) This weighing must be conducted... and before the bake oven where the coating applied to the panel is cured, 2.5.5.2All of the flash-off...

  9. The World Grain Economy and Climate Change to the Year 2000: Implications for Policy

    DTIC Science & Technology

    1983-01-01

    THE WORLD GRAIN ECONOMY AND CUMATE CHANGE TO THE YEAR 2000: IMPUCATIONS FOR POUCY REPORT ON THE FINAL PHASE OF A CLIMATE IMPACT ASSESSMENT CONDUCTED...MODEL...................................... 37 APPENDIX B-A SUMMARY OF CROP YIELDS AND CLIMATE CHANGE TOTHE YR00............33 CONTENTS LIST OF FIGURES...114. PROJECTED BASE 2000 YIELDS .................. 1S LIST OF TABLES 1. CLIMATE PARAMETERS BY LATITUDINAL ZONES .. S 2. SOURCES OF CLIMATE CHANGE

  10. Effect of neonatal gene therapy on lumbar spine disease in mucopolysaccharidosis VII dogs

    PubMed Central

    Smith, Lachlan J; Martin, John T; O'Donnell, Patricia; Wang, Ping; Elliott, Dawn M; Haskins, Mark E; Ponder, Katherine P

    2012-01-01

    Mucopolysaccharidosis VII (MPS VII) is due to deficient β-glucuronidase (GUSB) activity, which leads to accumulation of chondroitin, heparan, and dermatan sulfate glycosaminoglycans in various tissues including those of the spine. Associated spine disease can be due to abnormalities in the vertebrae, the intervertebral discs, or other spine tissues. The goal of this study was to determine if neonatal gene therapy could prevent lumbar spine disease in MPS VII dogs. MPS VII dogs were injected intravenously with a retroviral vector (RV) expressing canine GUSB at 2 to 3 days after birth, which resulted in transduction of hepatocytes that secreted GUSB into blood. Expression was stable for up to 11 years, and mean survival was increased from 0.4 years in untreated dogs to 6.1 years in treated dogs. Despite a profound positive clinical effect, 6-month-old RV-treated MPS VII dogs still had hypoplastic ventral epiphyses with reduced calcification in the lumbar spine, which resulted in a reduced stiffness and increased range of motion that was not improved relative to untreated MPS VII dogs. At six to 11 years of age, ventral vertebrae remained hypoplastic in RV-treated MPS VII dogs, and there was desiccation of the nucleus pulposus in some discs. Histochemical staining demonstrated that discs did not have detectable GUSB activity despite high serum GUSB activity, which is likely due to poor diffusion into this relatively avascular structure. Thus, neonatal gene therapy cannot prevent lumbar spine disease in MPS VII dogs, which predicts that enzyme replacement therapy (ERT) will similarly be relatively ineffective even if started at birth. PMID:22510705

  11. [Establishment of nude mouse model with ovarian carcinomaand the effect of Paris Phyllin VII combined with silica nano complex on the inhibition and the antioxidant ability of ovarian carcinoma in nude mice].

    PubMed

    Chen, Jun; Wang, Bihang; Zhang, Jialing; Yang, Ruiqi; Fan, Limei

    2015-08-04

    To establish the research model of ovarian carcinoma in nude mice, and to explore the effect of Paris Phyllin VII combined with silica nano complex on the inhibition and the antioxidant ability of ovarian carcinoma in nude mice. Nude mice models with ovarian carcinoma were established by axillary subcutaneous inoculation of human SKOV3/DDP resistant ovarian cancer cell 200 µl and were used in the experiment. Treating the nude mice with Paris Phyllin VII combined with silica nano complex by gavage for 15 days to observe the weight change of the nude mice, tumor inhibition effect and changes of serum antioxidant capacity. Compared with the negative control group, tumor inhibition rate increased significantly in Paris Phyllin VII combined with silica nano complex treatment group, and was higher than that in both Paris Phyllin VII treatment only and silica nano composites treatment only group. The serum superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) level of Paris Phyllin VII combined with silica nano complex treatment group was significantly higher than that of control group, Paris Phyllin VII treatment only and silica nano composites treatment only group. The serum malonaldehyde (MDA) level of Paris Phyllin VII combined with silica nano complex treatment group was significantly lower than that of the negative control group. Paris Phyllin VII combined with silica nano complex treatment can inhibit the ovarian carcinoma in nude mice, which may mediate by the enhancement of antioxidant capability in nude mice with ovarian cancer.

  12. Angola Seismicity MAP

    NASA Astrophysics Data System (ADS)

    Neto, F. A. P.; Franca, G.

    2014-12-01

    The purpose of this job was to study and document the Angola natural seismicity, establishment of the first database seismic data to facilitate consultation and search for information on seismic activity in the country. The study was conducted based on query reports produced by National Institute of Meteorology and Geophysics (INAMET) 1968 to 2014 with emphasis to the work presented by Moreira (1968), that defined six seismogenic zones from macro seismic data, with highlighting is Zone of Sá da Bandeira (Lubango)-Chibemba-Oncócua-Iona. This is the most important of Angola seismic zone, covering the epicentral Quihita and Iona regions, geologically characterized by transcontinental structure tectono-magmatic activation of the Mesozoic with the installation of a wide variety of intrusive rocks of ultrabasic-alkaline composition, basic and alkaline, kimberlites and carbonatites, strongly marked by intense tectonism, presenting with several faults and fractures (locally called corredor de Lucapa). The earthquake of May 9, 1948 reached intensity VI on the Mercalli-Sieberg scale (MCS) in the locality of Quihita, and seismic active of Iona January 15, 1964, the main shock hit the grade VI-VII. Although not having significant seismicity rate can not be neglected, the other five zone are: Cassongue-Ganda-Massano de Amorim; Lola-Quilengues-Caluquembe; Gago Coutinho-zone; Cuima-Cachingues-Cambândua; The Upper Zambezi zone. We also analyzed technical reports on the seismicity of the middle Kwanza produced by Hidroproekt (GAMEK) region as well as international seismic bulletins of the International Seismological Centre (ISC), United States Geological Survey (USGS), and these data served for instrumental location of the epicenters. All compiled information made possible the creation of the First datbase of seismic data for Angola, preparing the map of seismicity with the reconfirmation of the main seismic zones defined by Moreira (1968) and the identification of a new seismic zone Porto Amboim in the coastal portion of Kwanza basin sedimentary.

  13. Gene disruption reveals a dispensable role for plasmepsin VII in the Plasmodium berghei life cycle.

    PubMed

    Mastan, Babu S; Kumari, Anchala; Gupta, Dinesh; Mishra, Satish; Kumar, Kota Arun

    2014-06-01

    Plasmepsins (PM), aspartic proteases of Plasmodium, comprises a family of ten proteins that perform critical functions in Plasmodium life cycle. Except VII and VIII, functions of the remaining plasmepsin members have been well characterized. Here, we have generated a mutant parasite lacking PM VII in Plasmodium berghei using reverse genetics approach. Systematic comparison of growth kinetics and infection in both mosquito and vertebrate host revealed that PM VII depleted mutants exhibited no defects in development and progressed normally throughout the parasite life cycle. These studies suggest a dispensable role for PM VII in Plasmodium berghei life cycle. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. National Waterways Study. Waterway Science and Technology.

    DTIC Science & Technology

    1981-08-01

    Revetments 278 VII-A Split Hull Type Trailing Suction Hopper Dredge 304 VII-B Drag Heads 306 VII-C Overflow Systems 307 VII-D Trailing Suction Hopper... head reversals are possible. Poor approach conditions currently exist at some locks which could have been mitigated if modern, improved design...of ti,.c that a navigable pass section can be used. Navigation dams must be designed to pass high flows and floods with minor swell head and without in

  15. Improving the Timeliness of Equal Employment Opportunity Complaint Processing in Department of Defense

    DTIC Science & Technology

    2015-01-01

    1964 (Title VII) and the Pregnancy Discrimination Act amendment to Title VII, the Equal Pay Act of 1963, the Age Discrimi- nation in Employment Act of...Act of 1964 (Title VII) and the Pregnancy Discrimination Act amendment to Title VII, the Equal Pay Act of 1963, the Age Discrimination in...EEO programs uti - lize training on the EEO complaint process and framing of claims and that they use more-structured investigation requests

  16. Age-dependent regulation of ERF-VII transcription factor activity in Arabidopsis thaliana.

    PubMed

    Giuntoli, Beatrice; Shukla, Vinay; Maggiorelli, Federica; Giorgi, Federico M; Lombardi, Lara; Perata, Pierdomenico; Licausi, Francesco

    2017-10-01

    The Group VII Ethylene Responsive Factors (ERFs-VII) RAP2.2 and RAP2.12 have been mainly characterized with regard to their contribution as activators of fermentation in plants. However, transcriptional changes measured in conditions that stabilize these transcription factors exceed the mere activation of this biochemical pathway, implying additional roles performed by the ERF-VIIs in other processes. We evaluated gene expression in transgenic Arabidopsis lines expressing a stabilized form of RAP2.12, or hampered in ERF-VII activity, and identified genes affected by this transcriptional regulator and its homologs, including some involved in oxidative stress response, which are not universally induced under anaerobic conditions. The contribution of the ERF-VIIs in regulating this set of genes in response to chemically induced or submergence-stimulated mitochondria malfunctioning was found to depend on the plant developmental stage. A similar age-dependent mechanism also restrained ERF-VII activity upon the core-hypoxic genes, independently of the N-end rule pathway, which is accounted for the control of the anaerobic response. To conclude, this study shed new light on a dual role of ERF-VII proteins under submergence: as positive regulators of the hypoxic response and as repressors of oxidative-stress related genes, depending on the developmental stage at which plants are challenged by stress conditions. © 2017 John Wiley & Sons Ltd.

  17. Active site mutant transgene confers tolerance to human β-glucuronidase without affecting the phenotype of MPS VII mice

    PubMed Central

    Sly, William S.; Vogler, Carole; Grubb, Jeffrey H.; Zhou, Mi; Jiang, Jinxing; Zhou, Xiao Yan; Tomatsu, Shunji; Bi, Yanhua; Snella, Elizabeth M.

    2001-01-01

    Mucopolysaccharidosis type VII (MPS VII; Sly syndrome) is an autosomal recessive lysosomal storage disorder due to an inherited deficiency of β-glucuronidase. A naturally occurring mouse model for this disease was discovered at The Jackson Laboratory and shown to be due to homozygosity for a 1-bp deletion in exon 10 of the gus gene. The murine model MPS VII (gusmps/mps) has been very well characterized and used extensively to evaluate experimental strategies for lysosomal storage diseases, including bone marrow transplantation, enzyme replacement therapy, and gene therapy. To enhance the value of this model for enzyme and gene therapy, we produced a transgenic mouse expressing the human β-glucuronidase cDNA with an amino acid substitution at the active site nucleophile (E540A) and bred it onto the MPS VII (gusmps/mps) background. We demonstrate here that the mutant mice bearing the active site mutant human transgene retain the clinical, morphological, biochemical, and histopathological characteristics of the original MPS VII (gusmps/mps) mouse. However, they are now tolerant to immune challenge with human β-glucuronidase. This “tolerant MPS VII mouse model” should be useful for preclinical trials evaluating the effectiveness of enzyme and/or gene therapy with the human gene products likely to be administered to human patients with MPS VII. PMID:11226217

  18. Gene therapy ameliorates cardiovascular disease in dogs with mucopolysaccharidosis VII.

    PubMed

    Sleeper, M M; Fornasari, B; Ellinwood, N M; Weil, M A; Melniczek, J; O'Malley, T M; Sammarco, C D; Xu, L; Ponder, K P; Haskins, M E

    2004-08-17

    Mucopolysaccharidosis VII (MPS VII) is a lysosomal storage disease caused by deficient beta-glucuronidase (GUSB) activity resulting in defective catabolism of glycosaminoglycans (GAGs). Cardiac disease is a major cause of death in MPS VII because of accumulation of GAGs in cardiovascular cells. Manifestations include cardiomyopathy, mitral and aortic valve thickening, and aortic root dilation and may cause death in the early months of life or may be compatible with a fairly normal lifespan. We previously reported that neonatal administration of a retroviral vector (RV) resulted in transduction of hepatocytes, which secreted GUSB into the blood and could be taken up by cells throughout the body. The goal of this study was to evaluate the effect on cardiac disease. Six MPS VII dogs were treated intravenously with an RV-expressing canine GUSB. Echocardiographic parameters, cardiovascular lesions, and biochemical parameters of these dogs were compared with those of normal and untreated MPS VII dogs. RV-treated dogs were markedly improved compared with untreated MPS VII dogs. Most RV-treated MPS VII dogs had mild or moderate mitral regurgitation at 4 to 5 months after birth, which improved or disappeared when evaluated at 9 to 11 and at 24 months. Similarly, mitral valve thickening present early in some animals disappeared over time, whereas aortic dilation and aortic valve thickening were absent at all times. Both myocardium and aorta had significant levels of GUSB and reduction in GAGs.

  19. 29 CFR 1604.8 - Relationship of title VII to the Equal Pay Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... GUIDELINES ON DISCRIMINATION BECAUSE OF SEX § 1604.8 Relationship of title VII to the Equal Pay Act. (a) The employee coverage of the prohibitions against discrimination based on sex contained in title VII is...

  20. Weather applications and products enabled through vehicle infrastructure integration (VII) : feasibility and concept development study

    DOT National Transportation Integrated Search

    2007-01-01

    Vehicle Infrastructure Integration (VII) involves the two-way wireless transmission of data from vehicle-to-vehicle and vehicle-to-infrastructure utilizing Dedicated Short Range Communications (DSRC). VII will enable the development of weather-relate...

  1. Vehicle infrastructure integration proof of concept : technical description--vehicle : final report

    DOT National Transportation Integrated Search

    2009-05-19

    This report provides the technical description of the VII system developed for the Cooperative Agreement VII Program between the USDOT and the VII Consortium. The basic architectural elements are summarized and detailed descriptions of the hardware a...

  2. Reduction and removal of heptavalent technetium from solution by Escherichia coli.

    PubMed

    Lloyd, J R; Cole, J A; Macaskie, L E

    1997-03-01

    Anaerobic, but not aerobic, cultures of Escherichia coli accumulated Tc(VII) and reduced it to a black insoluble precipitate. Tc was the predominant element detected when the precipitate was analyzed by proton-induced X-ray emission. Electron microscopy in combination with energy-dispersive X-ray analysis showed that the site of Tc deposition was intracellular. It is proposed that Tc precipitation was a result of enzymatically mediated reduction of Tc(VII) to an insoluble oxide. Formate was an effective electron donor for Tc(VII) reduction which could be replaced by pyruvate, glucose, or glycerol but not by acetate, lactate, succinate, or ethanol. Mutants defective in the synthesis of the transcription factor FNR, in molybdenum cofactor (molybdopterin guanine dinucleotide [MGD]) synthesis, or in formate dehydrogenase H synthesis were all defective in Tc(VII) reduction, implicating a role for the formate hydrogenlyase complex in Tc(VII) reduction. The following observations confirmed that the hydrogenase III (Hyc) component of formate hydrogenlyase in both essential and sufficient for Tc(VII) reduction: (i) dihydrogen could replace formate as an effective electron donor for Tc(VII) reduction by wild-type bacteria and mutants defective in MGD synthesis; (ii) the inability of fnr mutants to reduce Tc(VII) can be suppressed phenotypically by growth with 250 microM Ni2+ and formate; (iii) Tc(VII) reduction is defective in a hyc mutant; (iv) the ability to reduce Tc(VII) was repressed during anaerobic growth in the presence of nitrate, but this repression was counteracted by the addition of formate to the growth medium; (v) H2, but not formate, was an effective electron donor for a Sel- mutant which is unable to incorporate selenocysteine into any of the three known formate dehydrogenases of E. coli. This appears to be the first report of Hyc functioning as an H2-oxidizing hydrogenase or as a dissimilatory metal ion reductase in enteric bacteria.

  3. Expanding the Versatility of Phage Display II: Improved Affinity Selection of Folded Domains on Protein VII and IX of the Filamentous Phage

    PubMed Central

    Løset, Geir Åge; Roos, Norbert; Bogen, Bjarne; Sandlie, Inger

    2011-01-01

    Background Phage display is a leading technology for selection of binders with affinity for specific target molecules. Polypeptides are normally displayed as fusions to the major coat protein VIII (pVIII) or the minor coat protein III (pIII). Whereas pVIII display suffers from drawbacks such as heterogeneity in display levels and polypeptide fusion size limitations, toxicity and infection interference effects have been described for pIII display. Thus, display on other coat proteins such as pVII or pIX might be more attractive. Neither pVII nor pIX display have gained widespread use or been characterized in detail like pIII and pVIII display. Methodology/Principal Findings Here we present a side-by-side comparison of display on pIII with display on pVII and pIX. Polypeptides of interest (POIs) are fused to pVII or pIX. The N-terminal periplasmic signal sequence, which is required for phage integration of pIII and pVIII and that has been added to pVII and pIX in earlier studies, is omitted altogether. Although the POI display level on pIII is higher than on pVII and pIX, affinity selection with pVII and pIX display libraries is shown to be particularly efficient. Conclusions/Significance Display through pVII and/or pIX represent platforms with characteristics that differ from those of the pIII platform. We have explored this to increase the performance and expand the use of phage display. In the paper, we describe effective affinity selection of folded domains displayed on pVII or pIX. This makes both platforms more attractive alternatives to conventional pIII and pVIII display than they were before. PMID:21390283

  4. Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures

    PubMed Central

    Ruusuvuori, Eva; Huebner, Antje K; Kirilkin, Ilya; Yukin, Alexey Y; Blaesse, Peter; Helmy, Mohamed; Jung Kang, Hyo; El Muayed, Malek; Christopher Hennings, J; Voipio, Juha; Šestan, Nenad; Hübner, Christian A; Kaila, Kai

    2013-01-01

    Brain carbonic anhydrases (CAs) are known to modulate neuronal signalling. Using a novel CA VII (Car7) knockout (KO) mouse as well as a CA II (Car2) KO and a CA II/VII double KO, we show that mature hippocampal pyramidal neurons are endowed with two cytosolic isoforms. CA VII is predominantly expressed by neurons starting around postnatal day 10 (P10). The ubiquitous isoform II is expressed in neurons at P20. Both isoforms enhance bicarbonate-driven GABAergic excitation during intense GABAA-receptor activation. P13–14 CA VII KO mice show behavioural manifestations atypical of experimental febrile seizures (eFS) and a complete absence of electrographic seizures. A low dose of diazepam promotes eFS in P13–P14 rat pups, whereas seizures are blocked at higher concentrations that suppress breathing. Thus, the respiratory alkalosis-dependent eFS are exacerbated by GABAergic excitation. We found that CA VII mRNA is expressed in the human cerebral cortex before the age when febrile seizures (FS) occur in children. Our data indicate that CA VII is a key molecule in age-dependent neuronal pH regulation with consequent effects on generation of FS. PMID:23881097

  5. Skull Base Invasion Patterns and Survival Outcomes of Nonmelanoma Skin Cancers

    PubMed Central

    Dundar, Yusuf; Cannon, Richard B.; Monroe, Marcus M.; Buchmann, Luke Oliver; Hunt, Jason Patrick

    2016-01-01

    Objective Report routes of skull base invasion for head and neck nonmelanoma skin cancers (NMSCs) and their survival outcomes. Design Retrospective. Participants Ninety patients with NMSC with skull base invasion between 2004 and 2014. Major Outcome Measures Demographic, tumor characteristics, and treatments associated with different types of skull base invasion and disease-specific survival (DSS) and overall survival (OS). Results Perineural invasion (PNI) to the skull base occurred in 69% of patients, whereas 38% had direct skull base invasion. Age, histology, orbital invasion, active immunosuppression, cranial nerve (CN) involved, and type of skull base invasion were significantly associated with DSS and OS (p < 0.05). Patients with basal cell carcinoma (BCC) had significantly improved DSS and OS compared with other histologies (p < 0.05). Patients with CN V PNI had significantly improved DSS and OS compared with CN VII PNI (p < 0.05). Patients with zone II PNI had significantly improved DSS and OS compared with those with direct invasion or zone III PNI (p < 0.05). Nonsurgical therapy was rarely used and is associated with a reduction in DSS and OS (p < 0.05). Conclusion Patterns and survival outcomes for NMSC skull base invasion are reported. Zone II PNI, BCC, and CN V PNI are associated with improved survival outcomes. PMID:28321381

  6. Acquired factor VII deficiency associated with acute myeloid leukemia.

    PubMed

    Anoun, Soumaya; Lamchahab, Mouna; Oukkache, Bouchra; Qachouh, Maryam; Benchekroun, Said; Quessar, Asmaa

    2015-04-01

    Isolated acquired factor VII deficiency is a rare coagulopathy. It has been reported in 31 patients with malignancy, sepsis, postoperatively, aplastic anemia, and during bone marrow transplantation. We discuss, through a new case of acquired factor VII deficiency, the characteristics of this disease when it is associated with acute myeloid leukemia. Acquired factor VII deficiency in hematological diseases can be caused by intensive chemotherapy, infections, or hepatic dysfunction. The best treatment in developing countries remains corticosteroids associated with plasma exchange, frozen plasma, and antibiotics.

  7. Prophylactic Level VII Nodal Dissection as a Prognostic Factor in Papillary Thyroid Carcinoma: a Pilot Study of 27 Patients.

    PubMed

    Fayek, Ihab Samy

    2015-01-01

    Prognostic value of prophylactic level VII nodal dissection in papillary thyroid carcinoma has been highlighted. A total of 27 patients with papillary thyroid carcinoma with N0 neck underwent total thyroidectomy with level VI and VII nodal dissection through same collar neck incision. Multicentricity, bilaterality, extrathyroidal extension, level VI and VII lymph nodes were studied as separate and independent prognostic factors for DFS at 24 months. 21 females and 6 males with a mean age of 34.6 years old, tumor size was 5-24 mm. (mean 12.4 mm.), multicentricity in 11 patients 2-4 foci (mean 2.7), bilaterality in 8 patients and extrathyroidal extension in 8 patients. Dissected level VI LNs 2-8 (mean 5 LNs) and level VII LNs 1-4 (mean 1.9). Metastatic level VI LNs 0-3 (mean 1) and level VII LNs 0-2 (mean 0.5). Follow-up from 6-51 months (mean 25.6) with 7 patients showed recurrence (3 local and 4 distant). Cumulative DFS at 24 months was 87.8% and was significantly affected in relation to bilaterality (p-value<0.001), extrathyroidal extension (p-value<0.001), level VI positive ((p-value<0.001) and level VII positive ((p-value<0.001) LNs. No recurrences were detected during the follow-up period in the absence of level VI and level VII nodal involvement. Level VII prophylactic nodal dissection is an important and integral prognostic factor in papillary thyroid carcinoma. A larger multicenter study is crucial to reach a satisfactory conclusion about the necessity and safety of this approach.

  8. Pathogenesis of aortic dilatation in mucopolysaccharidosis VII mice may involve complement activation

    PubMed Central

    Baldo, Guilherme; Wu, Susan; Howe, Ruth A.; Ramamoothy, Meera; Knutsen, Russell H.; Fang, Jiali; Mecham, Robert P.; Liu, Yuli; Wu, Xiaobo; Atkinson, John P.; Ponder, Katherine P.

    2012-01-01

    Mucopolysaccharidosis VII (MPS VII) is due to mutations within the gene encoding the lysosomal enzyme β-glucuronidase, and results in the accumulation of glycosaminoglycans. MPS VII causes aortic dilatation and elastin fragmentation, which is associated with upregulation of the elastases cathepsin S (CtsS) and matrix metalloproteinase 12 (MMP12). To test the role of these enzymes, MPS VII mice were crossed with mice deficient in CtsS or MMP12, and the effect upon aortic dilatation was determined. CtsS deficiency did not protect against aortic dilatation in MPS VII mice, but also failed to prevent an upregulation of cathepsin enzyme activity. Further analysis with substrates and inhibitors specific for particular cathepsins suggests that this enzyme activity was due to CtsB, which could contribute to elastin fragmentation. Similarly, MMP12 deficiency and deficiency of both MMP12 and CtsS could not prevent aortic dilatation in MPS VII mice. Microarray and reverse-transcriptase real-time PCR were performed to look for upregulation of other elastases. This demonstrated that mRNA for complement component D was elevated in MPS VII mice, while immunostaining demonstrated high levels of complement component C3 on surfaces within the aortic media. Finally, we demonstrate that neonatal intravenous injection of a retroviral vector encoding β-glucuronidase reduced aortic dilatation. We conclude that neither CtsS nor MMP12 are necessary for elastin fragmentation in MPS VII mouse aorta, and propose that CtsB and/or complement component D may be involved. Complement may be activated by the GAGs that accumulate, and may play a role in signal transduction pathways that upregulate elastases. PMID:21944884

  9. Effect of neonatal gene therapy on lumbar spine disease in mucopolysaccharidosis VII dogs.

    PubMed

    Smith, Lachlan J; Martin, John T; O'Donnell, Patricia; Wang, Ping; Elliott, Dawn M; Haskins, Mark E; Ponder, Katherine P

    2012-09-01

    Mucopolysaccharidosis VII (MPS VII) is due to deficient β-glucuronidase (GUSB) activity, which leads to accumulation of chondroitin, heparan, and dermatan sulfate glycosaminoglycans in various tissues including those of the spine. Associated spine disease can be due to abnormalities in the vertebrae, the intervertebral disks, or other spine tissues. The goal of this study was to determine if neonatal gene therapy could prevent lumbar spine disease in MPS VII dogs. MPS VII dogs were injected intravenously with a retroviral vector (RV) expressing canine GUSB at 2 to 3 days after birth, which resulted in transduction of hepatocytes that secreted GUSB into blood. Expression was stable for up to 11 years, and mean survival was increased from 0.4 years in untreated dogs to 6.1 years in treated dogs. Despite a profound positive clinical effect, 6-month-old RV-treated MPS VII dogs still had hypoplastic ventral epiphyses with reduced calcification in the lumbar spine, which resulted in a reduced stiffness and increased range of motion that were not improved relative to untreated MPS VII dogs. At six to 11 years of age, ventral vertebrae remained hypoplastic in RV-treated MPS VII dogs, and there was desiccation of the nucleus pulposus in some disks. Histochemical staining demonstrated that disks did not have detectable GUSB activity despite high serum GUSB activity, which is likely due to poor diffusion into this relatively avascular structure. Thus, neonatal gene therapy cannot prevent lumbar spine disease in MPS VII dogs, which predicts that enzyme replacement therapy (ERT) will similarly be relatively ineffective even if started at birth. Copyright © 2012 Elsevier Inc. All rights reserved.

  10. The Effect of Neonatal Gene Therapy with a Gamma Retroviral Vector on Cardiac Valve Disease in Mucopolysaccharidosis VII Dogs after a Decade

    PubMed Central

    Bigg, Paul W.; Sleeper, Meg M.; O’Donnell, Patricia A.; Liu, Yuli; Wu, Susan; Casal, Margret L.; Haskins, Mark E.; Ponder, Katherine P.

    2013-01-01

    Mucopolysaccharidosis VII (MPS VII) is due to deficient activity of the lysosomal enzyme β-glucuronidase (GUSB) and results in the accumulation of glycosaminoglycans (GAGs). This study determined the long-term effect of neonatal intravenous injection of a gamma retroviral vector (RV) on cardiac valve disease in MPS VII dogs. Transduced hepatocytes secreted GUSB into blood for up to 11 years at levels similar to or greater than those achieved with enzyme replacement therapy (ERT). Valve regurgitation and thickening were scored from 0 (normal) to +4 (severely abnormal). At 1 year, untreated MPS VII dogs had mitral regurgitation, mitral valve thickening, aortic regurgitation, and aortic valve thickening scores of 2.3±0.7, 2.3±0.6, 1.8±0.5, and 1.6±0.7, respectively, which were higher than the values of 0.6±0.1, 0.1±0.4, 0.3±0.8, and 0.1±0.4, respectively, in treated MPS VII dogs. Treated MPS VII dogs maintained low aortic regurgitation and aortic valve thickening scores for their lifetime. Although mitral regurgitation and mitral valve thickening scores increased to 2.0 at ≥8 years of age in the treated MPS VII dogs, older normal dogs from the colony had similar scores, making it difficult to assess mitral valve disease. Older treated dogs had calcification within the mitral and aortic valve annulus, while GUSB staining demonstrated enzyme activity within the mitral valve. We conclude that neonatal RV-mediated gene therapy reduced cardiac valve disease in MPS VII dogs for up to 11 years, and propose that neonatal initiation of ERT should have a similar effect. PMID:23860311

  11. The effect of neonatal gene therapy with a gamma retroviral vector on cardiac valve disease in mucopolysaccharidosis VII dogs after a decade.

    PubMed

    Bigg, Paul W; Sleeper, Meg M; O'Donnell, Patricia A; Liu, Yuli; Wu, Susan; Casal, Margret L; Haskins, Mark E; Ponder, Katherine P

    2013-11-01

    Mucopolysaccharidosis VII (MPS VII) is due to deficient activity of the lysosomal enzyme β-glucuronidase (GUSB) and results in the accumulation of glycosaminoglycans (GAGs). This study determined the long-term effect of neonatal intravenous injection of a gamma retroviral vector (RV) on cardiac valve disease in MPS VII dogs. Transduced hepatocytes secreted GUSB into the blood for up to 11 years at levels similar to or greater than those achieved with enzyme replacement therapy (ERT). Valve regurgitation and thickening were scored from 0 (normal) to +4 (severely abnormal). At 1 year, untreated MPS VII dogs had mitral regurgitation, mitral valve thickening, aortic regurgitation, and aortic valve thickening scores of 2.3 ± 0.7, 2.3 ± 0.6, 1.8 ± 0.5, and 1.6 ± 0.7, respectively, which were higher than the values of 0.6 ± 0.1, 0.1 ± 0.4, 0.3 ± 0.8, and 0.1 ± 0.4, respectively, in treated MPS VII dogs. Treated MPS VII dogs maintained low aortic regurgitation and aortic valve thickening scores in their lifetime. Although mitral regurgitation and mitral valve thickening scores increased to 2.0 at ≥ 8 years of age in the treated MPS VII dogs, older normal dogs from the colony had similar scores, making it difficult to assess mitral valve disease. Older treated dogs had calcification within the mitral and the aortic valve annulus, while GUSB staining demonstrated enzyme activity within the mitral valve. We conclude that neonatal RV-mediated gene therapy reduced cardiac valve disease in MPS VII dogs for up to 11 years, and propose that neonatal initiation of ERT should have a similar effect. © 2013.

  12. Nonredundant functions of Arabidopsis LecRK-V.2 and LecRK-VII.1 in controlling stomatal immunity and jasmonate-mediated stomatal closure.

    PubMed

    Yekondi, Shweta; Liang, Fu-Chun; Okuma, Eiji; Radziejwoski, Amandine; Mai, Hsien-Wei; Swain, Swadhin; Singh, Prashant; Gauthier, Mathieu; Chien, Hsiao-Chiao; Murata, Yoshiyuki; Zimmerli, Laurent

    2018-04-01

    Stomatal immunity restricts bacterial entry to leaves through the recognition of microbe-associated molecular patterns (MAMPs) by pattern-recognition receptors (PRRs) and downstream abscisic acid and salicylic acid signaling. Through a reverse genetics approach, we characterized the function of the L-type lectin receptor kinase-V.2 (LecRK-V.2) and -VII.1 (LecRK-VII.1). Analyses of interactions with the PRR FLAGELLIN SENSING2 (FLS2) were performed by co-immunoprecipitation and bimolecular fluorescence complementation and whole-cell patch-clamp analyses were used to evaluate guard cell Ca 2+ -permeable cation channels. The Arabidopsis thaliana LecRK-V.2 and LecRK-VII.1 and notably their kinase activities were required for full activation of stomatal immunity. Knockout lecrk-V.2 and lecrk-VII.1 mutants were hyper-susceptible to Pseudomonas syringae infection and showed defective stomatal closure in response to bacteria or to the MAMPs flagellin and EF-Tu. By contrast, Arabidopsis over-expressing LecRK-V.2 or LecRK-VII.1 demonstrated a potentiated stomatal immunity. LecRK-V.2 and LecRK-VII.1 are shown to be part of the FLS2 PRR complex. In addition, LecRK-V.2 and LecRK-VII.1 were critical for methyl jasmonate (MeJA)-mediated stomatal closure, notably for MeJA-induced activation of guard cell Ca 2+ -permeable cation channels. This study highlights the role of LecRK-V.2 and LecRK-VII.1 in stomatal immunity at the FLS2 PRR complex and in MeJA-mediated stomatal closure. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

  13. [Epidemiology of occupational skin cancer due to UV-irradiation].

    PubMed

    Diepgen, T L; Drexler, H; Schmitt, J

    2012-10-01

    Skin cancer induced by occupational UV-irradiation is not an official occupational disease number in the appendix of the German ordinance on occupational diseases (Berufskrankheitenverordnung (BKV) but can be recognized as a "virtually" occupational disease according to § 9 (2) of the 7th book of the German Social Code (SGB VII). Epidemiological studies have demonstrated a positive, statistically significant and relevant association between occupational UV-irradiation and the risk of squamous cell carcinoma (SCC) and actinic keratoses (AK). Outdoor workers have on average a 100% higher risk to develop SCC compared to the general population. Therefore, the prerequisites for a new occupational disease are fulfilled and SCC and AK should be reported as an occupational disease if an additional 40% occupationally-related UV-irradiation is documented and the clinical criteria are typical for work- related skin cancer. Epidemiologic evidence also indicates a significant association between work-related UV-irradiation and basal cell carcinoma (BCC) risk: however the results are less consistent and the association is weaker than with SCC. There is an urgent need for further studies in outdoor workers on BCC and lentigo maligna melanoma.

  14. The first royal appendix abscess drainage.

    PubMed

    Ellis, Harold

    2015-05-01

    On January 22nd 1901, at Osborne House on the Isle of Wight, Queen Victoria, nearing her 82nd birthday and having ruled for 64 years, drew her last breath. Edward Prince of Wales, 59 years of age, was now King Edward VII. A year of mourning was proclaimed and his coronation scheduled for June 26th. It was unexpectedly delayed by an attack of royal appendicitis. On Saturday June 14th 1902, less than two weeks before the coronation, Edward travelled to Aldershot to attend a military review. It was a cold, rainy day and the King did not feel well. That night, his abdominal discomfort was getting worse and by five next morning the King's personal physician, Sir Francis Laking, was called to see him. Laking asked Sir Thomas Barlow, Physician-Extraordinary to the King, for a second opinion. By now there was fever, rigor and distinct tenderness in the right iliac fossa of the very obese abdomen. Under heavy sedation, the King was transferred to Windsor Castle, leaving his Queen, Alexandra, to review the parade of 30,000 soldiers gathered at Aldershot.

  15. Blister-inducing antibodies target multiple epitopes on collagen VII in mice

    PubMed Central

    Csorba, Kinga; Chiriac, Mircea Teodor; Florea, Florina; Ghinia, Miruna Georgiana; Licarete, Emilia; Rados, Andreea; Sas, Alexandra; Vuta, Vlad; Sitaru, Cassian

    2014-01-01

    Epidermolysis bullosa acquisita (EBA) is an autoimmune subepidermal blistering disease of mucous membranes and the skin caused by autoantibodies against collagen VII. In silico and wet laboratory epitope mapping studies revealed numerous distinct epitopes recognized by EBA patients' autoantibodies within the non-collagenous (NC)1 and NC2 domains of collagen VII. However, the distribution of pathogenic epitopes on collagen VII has not yet been described. In this study, we therefore performed an in vivo functional epitope mapping of pathogenic autoantibodies in experimental EBA. Animals (n = 10/group) immunized against fragments of the NC1 and NC2 domains of collagen VII or injected with antibodies generated against the same fragments developed to different extent experimental EBA. Our results demonstrate that antibodies targeting multiple, distinct epitopes distributed over the entire NC1, but not NC2 domain of collagen VII induce blistering skin disease in vivo. Our present findings have crucial implications for the development of antigen-specific B- and T cell-targeted therapies in EBA. PMID:25091020

  16. Adenovirus core protein VII contains distinct sequences that mediate targeting to the nucleus and nucleolus, and colocalization with human chromosomes.

    PubMed

    Lee, Tim W R; Blair, G Eric; Matthews, David A

    2003-12-01

    During adenovirus infection, following capsid dissociation, core protein VII enters the host cell nucleus complexed with adenovirus DNA. In order to determine whether protein VII may have an active role in this nuclear import, regions of the preVII gene were amplified by PCR, and further oligonucleotide mutants were designed with site-directed mutation of codons for the basic amino acids arginine and lysine. Fragments were cloned into a mammalian expression plasmid to express the peptides as N-terminal fusions to enhanced green fluorescent protein. Results demonstrate that preVII protein contains both nuclear and nucleolar targeting sequences. Such signals may be important in the delivery of adenovirus DNA to the host cell nucleus during adenovirus infection. Furthermore, the data suggest that protein VII may bind to human chromosomes by means of two distinct domains, one sharing homology with the N-terminal regulatory tail of histone H3.

  17. The Effect of Neonatal Gene Therapy on Skeletal Manifestations in Mucopolysaccharidosis VII Dogs after a Decade

    PubMed Central

    Xing, Elizabeth M.; Knox, Van W.; O'Donnell, Patricia A.; Sikura, Tracey; Liu, Yuli; Wu, Susan; Casal, Margret L.; Haskins, Mark E.; Ponder, Katherine P.

    2013-01-01

    Mucopolysaccharidosis (MPS) VII is a lysosomal storage disease due to deficient activity of β-glucuronidase (GUSB), and results in glycosaminoglycan accumulation. Skeletal manifestations include bone dysplasia, degenerative joint disease, and growth retardation. One gene therapy approach for MPS VII involves neonatal intravenous injection of a gamma retroviral vector expressing GUSB, which results in stable expression in liver and secretion of enzyme into blood at levels predicted to be similar or higher to enzyme replacement therapy. The goal of this study was to evaluate the long-term effect of neonatal gene therapy on skeletal manifestations in MPS VII dogs. Treated MPS VII dogs could walk throughout their lives, while untreated MPS VII dogs could not stand beyond 6 months and were dead by 2 years. Luxation of the coxofemoral joint and the patella, dysplasia of the acetabulum and supracondylar ridge, deep erosions of the distal femur, and synovial hyperplasia were reduced, and the quality of articular bone was improved in treated dogs at 6 to 11 years of age compared with untreated MPS VII dogs at 2 years or less. However, treated dogs continued to have osteophyte formation, cartilage abnormalities, and an abnormal gait. Enzyme activity was found near synovial blood vessels, and there was 2% as much GUSB activity in synovial fluid as in serum. We conclude that neonatal gene therapy reduces skeletal abnormalities in MPS VII dogs, but clinically-relevant abnormalities remain. Enzyme replacement therapy will probably have similar limitations long-term. PMID:23628461

  18. Oxidation of phenolic endocrine disrupting chemicals by potassium permanganate in synthetic and real waters.

    PubMed

    Jiang, Jin; Pang, Su-Yan; Ma, Jun; Liu, Huiling

    2012-02-07

    In this study, five selected environmentally relevant phenolic endocrine disrupting chemicals (EDCs), estrone, 17β-estradiol, estriol, 17α-ethinylestradiol, and 4-n-nonylphenol, were shown to exhibit similarly appreciable reactivity toward potassium permanganate [Mn(VII)] with a second-order rate constant at near neutral pH comparable to those of ferrate(VI) and chlorine but much lower than that of ozone. In comparison with these oxidants, however, Mn(VII) was much more effective for the oxidative removal of these EDCs in real waters, mainly due to the relatively high stability of Mn(VII) therein. Mn(VII) concentrations at low micromolar range were determined by an ABTS [2,2-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid diammonium] spectrophotometric method based on the stoichiometric reaction of Mn(VII) with ABTS [Mn(VII) + 5ABTS → Mn(II) + 5ABTS(•+)] forming a stable green radical cation (ABTS(•+)). Identification of oxidation products suggested the initial attack of Mn(VII) at the hydroxyl group in the aromatic ring of EDCs, leading to a series of quinone-like and ring-opening products. The background matrices of real waters as well as selected model ligands including phosphate, pyrophosphate, NTA, and humic acid were found to accelerate the oxidation dynamics of these EDCs by Mn(VII). This was explained by the effect of in situ formed dissolved Mn(III), which could readily oxidize these EDCs but would disproportionate spontaneously without stabilizing agents.

  19. Performance Monitoring of a Nearshore Berm at Ft. Myers Beach, Florida

    DTIC Science & Technology

    2013-08-01

    prototype designs. Coastal Zone ’93, American Society of Civil Engineers, pp. 2938 -2950. Andrassy, C . J. 1991. Monitoring of a nearshore disposal mound at...ER D C / CH L TR -1 3 -1 1 Performance Monitoring of a Nearshore Berm at Ft. Myers Beach, Florida: Final Report C oa st al a n d H yd...122  Appendix C : USF-CRL Survey Data: morphologic evolution during the first 2 years post construction

  20. 77 FR 546 - Adjustment of Nationwide Significant Risk Threshold

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ...In accordance with Appendix D to Title 49 Code of Federal Regulations (CFR) Part 222, Use of Locomotive Horns at Highway-Rail Grade Crossings, FRA is updating the Nationwide Significant Risk Threshold (NSRT). This action is needed to ensure that the public has the proper threshold of permissible risk for calculating quiet zones established in relationship to the NSRT. This is the fifth update to the NSRT, which has fallen from 14,007 to 13,722.

  1. 75 FR 82136 - Adjustment of Nationwide Significant Risk Threshold

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ...In accordance with Appendix D to Title 49 Code of Federal Regulations (CFR) Part 222, Use of Locomotive Horns at Highway-Rail Grade Crossings, FRA is updating the Nationwide Significant Risk Threshold (NSRT). This action is needed to ensure that the public has the proper threshold of permissible risk for calculating quiet zones established in relationship to the NSRT. This is the fourth update to the NSRT, which has fallen from 18,775 to 14,007.

  2. 78 FR 70623 - Adjustment of Nationwide Significant Risk Threshold

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-26

    ...In accordance with appendix D to title 49 Code of Federal Regulations (CFR) part 222, Use of Locomotive Horns at Public Highway- Rail Grade Crossings, FRA is updating the Nationwide Significant Risk Threshold (NSRT). This action is needed to ensure that the public has the proper threshold of permissible risk for calculating quiet zones established in relationship to the NSRT. This is the sixth update to the NSRT, which is increasing from 13,722 to 14,347.

  3. LEA Title VII Program Evaluations. Panel Presentations.

    ERIC Educational Resources Information Center

    Balu, Raj

    These panel presentations focus on LEA Title VII Program Evaluations. Raj Balu, an administrator of bilingual programs in Chicago presents information regarding the bilingual education program in the Chicago public schools, as well as information on Title VII programs and what kind of evaluation is being done. Jesus Salazar, who is currently…

  4. 32 CFR 2003.7 - Support Staff (Article VII).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Support Staff (Article VII). 2003.7 Section 2003... (ISCAP) BYLAWS, RULES, AND APPEAL PROCEDURES Bylaws § 2003.7 Support Staff (Article VII). The staff of..., provides program and administrative support for the Panel. The Executive Secretary supervises the staff in...

  5. 32 CFR 2003.7 - Support Staff (Article VII).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Support Staff (Article VII). 2003.7 Section 2003... (ISCAP) BYLAWS, RULES, AND APPEAL PROCEDURES Bylaws § 2003.7 Support Staff (Article VII). The staff of..., provides program and administrative support for the Panel. The Executive Secretary supervises the staff in...

  6. Interrelation between factor VII, prekallikrein, and hyperfibrinolysis in advanced cirrhosis.

    PubMed Central

    Violi, F; Alessandri, C; Ferro, D; Saliola, M; Cordova, C; Musca, A; Balsano, F

    1989-01-01

    Factor VII and prekallikrein activities were studied in 37 patients with liver cirrhosis who were in a decompensated state. Sixteen of them died 30-70 days after admission; 21 survived and were discharged after 30-80 days. Seven who died and six survivors had signs of hyperfibrinolysis: factor VII activity differentiated the two groups independently of the presence of hyperfibrinolysis. The presence of hyperfibrinolysis significantly reduced prekallikrein activity, which did not differentiate clearly survivors from non-survivors. Long term follow up of survivors showed a good correlation between factor VII and prekallikrein activities with long term survival. Hyperfibrinolysis seemed to influence the clinical course of patients: 87% of patients with hyperfibrinolysis who died had fatal haemorrhagic episodes. Low factor VII activity may be a precursor of terminal liver insufficiency. PMID:2613916

  7. Onset of ice VII phase during ps laser pulse propagation through liquid water

    NASA Astrophysics Data System (ADS)

    Kumar, V. Rakesh; Kiran, P. Prem

    2017-01-01

    Water dominantly present in liquid state on earth gets transformed to crystalline polymorphs under different dynamic loading conditions. Out of different crystalline phases discovered till date, ice VII is observed to be stable over wide pressure (2-63 GPa) and temperature (>273 K) ranges. The formation of ice VII crystalline structure has been vastly reported during high pressure static compression using diamond anvil cell and propagation of high energy (>50 mJ/pulse) nanosecond laser pulse induced dynamic high pressures through liquid water. We present the onset of ice VII phase at low threshold of 2 mJ/pulse during 30 ps (532 nm, 10 Hz) laser pulse induced shock propagating through liquid water. Role of input pulse energy on the evolution of Stoke's and anti-Stoke's Raman shift of the dominant A1g mode of ice VII, filamentation, free-electrons, plasma shielding is presented. The H-bond network rearrangement, electron ion energy transfer time coinciding with the excitation pulse duration supported by the filamentation and plasma shielding of the ps laser pulses reduced the threshold of ice VII structure formation. Filamentation and the plasma shielding have shown the localized creation and sustenance of ice VII structure in liquid water over 3 mm length and 50 μm area of cross-section.

  8. Management of Surgical Third Lower Molar Extraction and Postoperative Progress in Patients With Factor VII Deficiency: A Clinical Protocol and Focus on This Rare Pathologic Entity.

    PubMed

    Passarelli, Pier Carmine; Pasquantonio, Guido; D'Addona, Antonio

    2017-10-01

    The purpose of the present study was to analyze the management of surgical third molar extraction and postoperative progress in patients with a diagnosis of factor VII deficiency. Close collaboration between the oral-maxillofacial surgeon and hematologist will allow the team to categorize the risk and operate safely, thereby minimizing the incidence and severity of intraoperative and postoperative complications. The present retrospective study included 7 patients with factor VII deficiency who had undergone third lower molar surgery. Their factor VII deficiency ranged from 10.5 to 21.0%. Recombinant activated factor VII (rFVIIa) (coagulation factor VIIa [recombinant]; NovoSeven RT; Novo Nordisk, Bagsvaerd, Denmark) was transfused intravenously in a single dose of 25 μg/kg body weight, 30 minutes before surgical extractions. After the surgery, betamethasone, an analgesic, and an ice pack were administered. Pretreatment with recombinant activated factor VII resulted in excellent hemostasis. No hemorrhagic complications and no postoperative major bleeding were observed. The extraction of the third lower molar appears to be a safe procedure for patients with factor VII deficiency when appropriate prophylaxis with rFVIIa is used. Copyright © 2017 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  9. Adenovirus Core Protein VII Downregulates the DNA Damage Response on the Host Genome

    PubMed Central

    Avgousti, Daphne C.; Della Fera, Ashley N.; Otter, Clayton J.; Herrmann, Christin; Pancholi, Neha J.

    2017-01-01

    ABSTRACT Viral manipulation of cellular proteins allows viruses to suppress host defenses and generate infectious progeny. Due to the linear double-stranded DNA nature of the adenovirus genome, the cellular DNA damage response (DDR) is considered a barrier to successful infection. The adenovirus genome is packaged with protein VII, a virally encoded histone-like core protein that is suggested to protect incoming viral genomes from detection by the cellular DNA damage machinery. We showed that protein VII localizes to host chromatin during infection, leading us to hypothesize that protein VII may affect DNA damage responses on the cellular genome. Here we show that protein VII at cellular chromatin results in a significant decrease in accumulation of phosphorylated H2AX (γH2AX) following irradiation, indicating that protein VII inhibits DDR signaling. The oncoprotein SET was recently suggested to modulate the DDR by affecting access of repair proteins to chromatin. Since protein VII binds SET, we investigated a role for SET in DDR inhibition by protein VII. We show that knockdown of SET partially rescues the protein VII-induced decrease in γH2AX accumulation on the host genome, suggesting that SET is required for inhibition. Finally, we show that knockdown of SET also allows ATM to localize to incoming viral genomes bound by protein VII during infection with a mutant lacking early region E4. Together, our data suggest that the protein VII-SET interaction contributes to DDR evasion by adenovirus. Our results provide an additional example of a strategy used by adenovirus to abrogate the host DDR and show how viruses can modify cellular processes through manipulation of host chromatin. IMPORTANCE The DNA damage response (DDR) is a cellular network that is crucial for maintaining genome integrity. DNA viruses replicating in the nucleus challenge the resident genome and must overcome cellular responses, including the DDR. Adenoviruses are prevalent human pathogens that can cause a multitude of diseases, such as respiratory infections and conjunctivitis. Here we describe how a small adenovirus core protein that localizes to host chromatin during infection can globally downregulate the DDR. Our study focuses on key players in the damage signaling pathway and highlights how viral manipulation of chromatin may influence access of DDR proteins to the host genome. PMID:28794020

  10. Properties of synaptic transmission from the reticular formation dorsal to the facial nucleus to trigeminal motoneurons during early postnatal development in rats.

    PubMed

    Gemba-Nishimura, A; Inoue, T; Nakamura, S; Nakayama, K; Mochizuki, A; Shintani, S; Yoshimura, S

    2010-03-31

    We previously reported that electrical stimulation of the reticular formation dorsal to the facial nucleus (RdVII) elicited excitatory masseter responses at short latencies and that RdVII neurons were antidromically activated by stimulation of the trigeminal motor nucleus (MoV), suggesting that excitatory premotor neurons targeting the MoV are likely located in the RdVII. We thus examined the properties of synaptic transmission from the RdVII to jaw-closing and jaw-opening motoneurons in horizontal brainstem preparations from developing rats using voltage-sensitive dye, patch-clamp recordings and laser photostimulation. Electrical stimulation of the RdVII evoked optical responses in the MoV. Combined bath application of the non-N-methyl-d-aspartate (non-NMDA) receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), and the NMDA receptor antagonist DL-2-amino-5-phosphonopentanoic acid (APV) reduced these optical responses, and addition of the glycine receptor antagonist strychnine and the GABA(A) receptor antagonist bicuculline further reduced the remaining responses. Electrical stimulation of the RdVII evoked postsynaptic currents (PSCs) in all 19 masseter motoneurons tested in postnatal day (P)1-4 rats, and application of CNQX and the NMDA receptor antagonist (+/-)-3(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) reduced the PSC amplitudes by more than 50%. In the presence of CNQX and CPP, the GABA(A) receptor antagonist SR95531 further reduced PSC amplitude, and addition of strychnine abolished the remaining PSCs. Photostimulation of the RdVII with caged glutamate also evoked PSCs in masseter motoneurons of P3-4 rats. In P8-11 rats, electrical stimulation of the RdVII also evoked PSCs in all 14 masseter motoneurons tested, and the effects of the antagonists on the PSCs were similar to those in P1-4 rats. On the other hand, RdVII stimulation evoked PSCs in only three of 16 digastric motoneurons tested. These results suggest that both neonatal and juvenile jaw-closing motoneurons receive strong synaptic inputs from the RdVII through activation of glutamate, glycine and GABA(A) receptors, whereas inputs from the RdVII to jaw-opening motoneurons seem to be weak. Copyright 2010 IBRO. Published by Elsevier Ltd. All rights reserved.

  11. Differential regulation and impact of fucosyltransferase VII and core 2 β1,6-N-acetyl-glycosaminyltransferase for generation of E-selectin and P-selectin ligands in murine CD4+ T cells

    PubMed Central

    Schroeter, Micha F; Ratsch, Boris A; Lehmann, Jeanette; Baumgrass, Ria; Hamann, Alf; Syrbe, Uta

    2012-01-01

    Ligands for E-selectin and P-selectin (E-lig and P-lig) are induced on CD4+ T cells upon differentiation into effector T cells. Glycosyltransferases, especially α 1,3-fucosyltransferase VII (FucT-VII) and core 2 β1,6-N-acetyl-glycosaminyltransferase I (C2GlcNAcT-I), are critical for their synthesis. We here analysed the signals that control the expression of E-lig, P-lig and mRNA coding for FucT-VII and C2GlcNAcT-I. In line with previous reports, we found that P-lig expression correlates with the regulation of C2GlcNAcT-I, whereas E-lig expression can occur at low levels of C2GlcNAcT-I mRNA but requires high FucT-VII mRNA expression. Interestingly, the two enzymes are regulated by different signals. Activation-induced C2GlcNAcT-I up-regulation under permissive (T helper type 1) conditions was strongly reduced by cyclosporin A (CsA), suggesting the involvement of T-cell receptor-dependent, calcineurin/NFAT-dependent signals in combination with interleukin-12 (IL-12) -mediated signals in the regulation of C2GlcNAcT-I. In contrast, expression of FucT-VII mRNA was not significantly inhibited by CsA. Interleukin-4 inhibited the expression of FucT-VII but IL-2 and IL-7 were found to support induction of FucT-VII and E-lig. E-selectin, P-selectin and their ligands initially appeared to have rather overlapping functions. These findings however, unravel striking differences in the regulation of E-lig and P-lig expression, dictated by the dominance of FucT-VII and C2GlcNAcT-I, respectively, and their dependency on signals from either promiscuous or homeostatic cytokines (FucT-VII) or a strong T-cell receptor signal in combination with inflammatory cytokines in case of C2GlcNAcT-I. PMID:23039181

  12. The effect of neonatal gene therapy on skeletal manifestations in mucopolysaccharidosis VII dogs after a decade.

    PubMed

    Xing, Elizabeth M; Knox, Van W; O'Donnell, Patricia A; Sikura, Tracey; Liu, Yuli; Wu, Susan; Casal, Margret L; Haskins, Mark E; Ponder, Katherine P

    2013-06-01

    Mucopolysaccharidosis (MPS) VII is a lysosomal storage disease due to deficient activity of β-glucuronidase (GUSB), and results in glycosaminoglycan accumulation. Skeletal manifestations include bone dysplasia, degenerative joint disease, and growth retardation. One gene therapy approach for MPS VII involves neonatal intravenous injection of a gamma retroviral vector expressing GUSB, which results in stable expression in liver and secretion of enzyme into blood at levels predicted to be similar or higher to enzyme replacement therapy. The goal of this study was to evaluate the long-term effect of neonatal gene therapy on skeletal manifestations in MPS VII dogs. Treated MPS VII dogs could walk throughout their lives, while untreated MPS VII dogs could not stand beyond 6 months and were dead by 2 years. Luxation of the coxofemoral joint and the patella, dysplasia of the acetabulum and supracondylar ridge, deep erosions of the distal femur, and synovial hyperplasia were reduced, and the quality of articular bone was improved in treated dogs at 6 to 11 years of age compared with untreated MPS VII dogs at 2 years or less. However, treated dogs continued to have osteophyte formation, cartilage abnormalities, and an abnormal gait. Enzyme activity was found near synovial blood vessels, and there was 2% as much GUSB activity in synovial fluid as in serum. We conclude that neonatal gene therapy reduces skeletal abnormalities in MPS VII dogs, but clinically-relevant abnormalities remain. Enzyme replacement therapy will probably have similar limitations long-term. Copyright © 2013 Elsevier Inc. All rights reserved.

  13. Radiographic evaluation of bones and joints in mucopolysaccharidosis I and VII dogs after neonatal gene therapy.

    PubMed

    Herati, Ramin Sedaghat; Knox, Van W; O'Donnell, Patricia; D'Angelo, Marina; Haskins, Mark E; Ponder, Katherine P

    2008-11-01

    Mucopolysaccharidosis I (MPS I) and MPS VII are due to deficient activity of the glycosaminoglycan-degrading lysosomal enzymes alpha-L-iduronidase and beta-glucuronidase, respectively, and result in abnormal bones and joints. Here, the severity of skeletal disease in MPS I and MPS VII dogs and the effects of neonatal gene therapy were evaluated. For untreated MPS VII dogs, the lengths of the second cervical vertebrae (C2) and the femur were only 56% and 84% of normal, respectively, and bone dysplasia and articular erosions, and joint subluxation were severe. Previously, we reported that neonatal intravenous injection of a retroviral vector (RV) with the appropriate gene resulted in expression in liver and blood cells, and high serum enzyme activity. In this study, we demonstrate that C2 and femurs of RV-treated MPS VII dogs were longer at 82% and 101% of normal, respectively, and there were partial improvements of qualitative abnormalities. For untreated MPS I dogs, the lengths of C2 and femurs (91% and 96% of normal, respectively) were not significantly different from normal dogs. Qualitative changes in MPS I bones and joints were generally modest and were partially improved with RV treatment, although cervical spine disease was severe and was difficult to correct with gene therapy in both models. The greater severity of skeletal disease in MPS VII than in MPS I dogs may reflect accumulation of chondroitin sulfate in cartilage in MPS VII, or could relate to the specific mutations. Neonatal RV-mediated gene therapy ameliorates, but does not prevent, skeletal disease in MPS I and MPS VII dogs.

  14. Pathogenesis of mitral valve disease in mucopolysaccharidosis VII dogs.

    PubMed

    Bigg, Paul W; Baldo, Guilherme; Sleeper, Meg M; O'Donnell, Patricia A; Bai, Hanqing; Rokkam, Venkata R P; Liu, Yuli; Wu, Susan; Giugliani, Roberto; Casal, Margret L; Haskins, Mark E; Ponder, Katherine P

    2013-11-01

    Mucopolysaccharidosis VII (MPS VII) is due to the deficient activity of β-glucuronidase (GUSB) and results in the accumulation of glycosaminoglycans (GAGs) in lysosomes and multisystemic disease with cardiovascular manifestations. The goal here was to determine the pathogenesis of mitral valve (MV) disease in MPS VII dogs. Untreated MPS VII dogs had a marked reduction in the histochemical signal for structurally-intact collagen in the MV at 6 months of age, when mitral regurgitation had developed. Electron microscopy demonstrated that collagen fibrils were of normal diameter, but failed to align into large parallel arrays. mRNA analysis demonstrated a modest reduction in the expression of genes that encode collagen or collagen-associated proteins such as the proteoglycan decorin which helps collagen fibrils assemble, and a marked increase for genes that encode proteases such as cathepsins. Indeed, enzyme activity for cathepsin B (CtsB) was 19-fold normal. MPS VII dogs that received neonatal intravenous injection of a gamma retroviral vector had an improved signal for structurally-intact collagen, and reduced CtsB activity relative to that seen in untreated MPS VII dogs. We conclude that MR in untreated MPS VII dogs was likely due to abnormalities in MV collagen structure. This could be due to upregulation of enzymes that degrade collagen or collagen-associated proteins, to the accumulation of GAGs that compete with proteoglycans such as decorin for binding to collagen, or to other causes. Further delineation of the etiology of abnormal collagen structure may lead to treatments that improve biomechanical properties of the MV and other tissues. © 2013.

  15. Pathogenesis of Mitral Valve Disease in Mucopolysaccharidosis VII Dogs

    PubMed Central

    Bigg, Paul W.; Baldo, Guilherme; Sleeper, Meg M.; O'Donnell, Patricia A.; Bai, Hanqing; Rokkam, Venkata R.P.; Liu, Yuli; Wu, Susan; Giugliani, Roberto; Casal, Margret L.; Haskins, Mark E.; Ponder, Katherine P.

    2013-01-01

    Mucopolysaccharidosis VII (MPS VII) is due to deficient activity of β-glucuronidase (GUSB) and results in the accumulation of glycosaminoglycans (GAGs) in lysosomes and multisystemic disease with cardiavascular manifestations. The goal here was to determine the pathogenesis of mitral valve (MV) disease in MPS VII dogs. Untreated MPS VII dogs had a marked reduction in the histochemical signal for structurally-intact collagen in the MV at 6 months of age, when mitral regurgitation had developed. Electron microscopy demonstrated that collagen fibrils were of normal diameter, but failed to align into large parallel arrays. mRNA analysis demonstrated a modest reduction in the expression of genes that encode collagen or collagen-associated proteins such as the proteoglycan decorin which helps collagen fibrils assemble, and a marked increase for genes that encode proteases such as cathepsins. Indeed, enzyme activity for cathepsin B (CtsB) was 19-fold normal. MPS VII dogs that received neonatal intravenous injection of a gamma retroviral vector had an improved signal for structurally-intact collagen, and reduced CtsB activity relative to that seen in untreated MPS VII dogs. We conclude that MR in untreated MPS VII dogs was likely due to abnormalities in MV collagen structure. This could be due to upregulation of enzymes that degrade collagen or collagen-associated proteins, to the accumulation of GAGs that compete with proteoglycans such as decorin for binding to collagen, or to other causes. Further delineation of the etiology of abnormal collagen structure may lead to treatments that improve biomechanical properties of the MV and other tissues. PMID:23856419

  16. 29 CFR 1910.16 - Longshoring and marine terminals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Ionizing radiation. Subpart Z, § 1910.1096; (vi) Noise. Subpart G, § 1910.95; (vii) Nonionizing radiation. Subpart G, § 1910.97; Note to paragraph (a)(2)(vii): Exposures to nonionizing radiation emissions from.... Subpart Z, § 1910.1200; (vii) Ionizing radiation. Subpart Z, § 1910.1096; (viii) Noise. Subpart G, § 1910...

  17. 48 CFR 952.227-14 - Rights in data-general. (DOE coverage-alternates VI and VII)

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... (DOE coverage-alternates VI and VII) 952.227-14 Section 952.227-14 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.227-14 Rights in data-general. (DOE coverage—alternates VI and VII) Alternate VI...

  18. 48 CFR 952.227-14 - Rights in data-general. (DOE coverage-alternates VI and VII)

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... (DOE coverage-alternates VI and VII) 952.227-14 Section 952.227-14 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.227-14 Rights in data-general. (DOE coverage—alternates VI and VII) Alternate VI...

  19. 48 CFR 952.227-14 - Rights in data-general. (DOE coverage-alternates VI and VII)

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    .... (DOE coverage-alternates VI and VII) 952.227-14 Section 952.227-14 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.227-14 Rights in data-general. (DOE coverage—alternates VI and VII) Alternate VI...

  20. 77 FR 14516 - Lock+ Hydro Friends Fund VII; Notice of Preliminary Permit Application Accepted for Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-12

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 14339-000] Lock+ Hydro Friends Fund VII; Notice of Preliminary Permit Application Accepted for Filing and Soliciting Comments, Motions To Intervene, and Competing Applications On December 22, 2011, Lock+ Hydro Friends Fund VII filed...

  1. 76 FR 24471 - Qualified Hydro 26, LLC; Lock+ Hydro Friends Fund VII; Western Minnesota Municipal Power Agency...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-02

    ...; 14113-000] Qualified Hydro 26, LLC; Lock+ Hydro Friends Fund VII; Western Minnesota Municipal Power... Hydro), Lock+ Hydro Friends Fund VII (Hydro Friends) and Western Minnesota Municipal Power Agency (WMMPA... 02114; (978) 283-2822. Hydro Friends' proposed Lock and Dam 11 Hydropower Project No. 14112 would...

  2. 76 FR 57013 - Recordkeeping and Reporting Requirements Under Title VII, the ADA, and GINA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... EQUAL EMPLOYMENT OPPORTUNITY COMMISSION 29 CFR Part 1602 RIN 3046-AA89 Recordkeeping and Reporting Requirements Under Title VII, the ADA, and GINA AGENCY: Equal Employment Opportunity Commission. ACTION... under title VII, the ADA, and GINA. (76 FR 31892, June 2, 2011). No requests to present oral testimony...

  3. A Method for Visualization of Incoming Adenovirus Chromatin Complexes in Fixed and Living Cells

    PubMed Central

    Komatsu, Tetsuro; Dacheux, Denis; Kreppel, Florian; Nagata, Kyosuke; Wodrich, Harald

    2015-01-01

    Inside the adenovirus virion, the genome forms a chromatin-like structure with viral basic core proteins. Core protein VII is the major DNA binding protein and was shown to remain associated with viral genomes upon virus entry even after nuclear delivery. It has been suggested that protein VII plays a regulatory role in viral gene expression and is a functional component of viral chromatin complexes in host cells. As such, protein VII could be used as a maker to track adenoviral chromatin complexes in vivo. In this study, we characterize a new monoclonal antibody against protein VII that stains incoming viral chromatin complexes following nuclear import. Furthermore, we describe the development of a novel imaging system that uses Template Activating Factor-I (TAF-I/SET), a cellular chromatin protein tightly bound to protein VII upon infection. This setup allows us not only to rapidly visualize protein VII foci in fixed cells but also to monitor their movement in living cells. These powerful tools can provide novel insights into the spatio-temporal regulation of incoming adenoviral chromatin complexes. PMID:26332038

  4. Contribution of tertiary amino groups to Re(VII) biosorption on modified corn stalk: competitiveness and regularity.

    PubMed

    Lou, Zhenning; Zhao, Ziyi; Li, Yexia; Shan, Weijun; Xiong, Ying; Fang, Dawei; Yue, Shuang; Zang, Shuliang

    2013-04-01

    The effects of basic strength and steric hindrance of gels modified by dimethylamine, diethylamine, di-n-octylamine and di-2-ethylhexylamine, respectively, on rhenium (Re(VII)) adsorption capacity and selectivity were discussed. By comparing with the adsorption of other coexisting metals, such as Mo(VI), Cu(II), Pb(II), Fe(III), Zn(II), Mn(VII) and Ni(II), the gel modified by di-n-octylamine (DNOA-OCS) showed a high affinity for Re(VII) at higher hydrochloric acid concentration (C(H)(+)≥1.0 mol L(-1)), and the maximum adsorption capacity was 98.69 mg g(-1). This article not only described the adsorption behavior but also suggested isotherms, kinetics and thermodynamics of Re(VII) onto the DNOA-OCS gel in an aqueous medium using several models. Further study on adsorption of rhenium in a fixed-bed column packed with the DNOA-OCS gel under continuous and recirculating modes could confirm that the corn stalk gel modified by di-n-octylamine could be used as the adsorbent of Re(VII) from Mo-containing wastewater. Copyright © 2013 Elsevier Ltd. All rights reserved.

  5. Demonstration of resonant photopumping of Mo VII by Mo XII for a VUV laser near 600 {Angstrom}

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ilcisin, K.J.; Aumayr, F.; Schwob, J.L.

    1993-09-01

    We present data of experiments on the resonant photopumping of Mo VII by Mo XII as a method of generating a coherent VUV source near 600 {angstrom}. The experiment is based on a scheme proposed by Feldman and Reader in which the 4p{sup 6} -- 4p{sup 5}6s transition in Mo VII in resonantly photopumped by the 5s {sup 2}S{sub 1/2} -- 4p {sup 2}P{sub 1/2} transition in Mo XII. Results of the laser produced plasma experiments show the successful enhancement of the population of the Mo VII 4p{sup 5}6s upper lasing level when pumped by an adjacent Mo VII plasma.more » No enhancement was seen in a control experiment where the Mo VII plasma was pumped by a Zr X plasma. Improvements of the intensity of the Mo XII pump source, achieved using an additional pump laser, lead to the generation of a population inversion for the VUV transition.« less

  6. Bovine adenovirus 3 core protein precursor pVII localizes to mitochondria, and modulates ATP synthesis, mitochondrial Ca2+ and mitochondrial membrane potential.

    PubMed

    Anand, Sanjeev K; Gaba, Amit; Singh, Jaswant; Tikoo, Suresh K

    2014-02-01

    Viruses modulate the functions of mitochondria by translocating viral proteins to the mitochondria. Subcellular fractionation and sensitivity to proteinase K/Triton X-100 treatment of mitochondrial fractions of bovine adenovirus (BAdV)-3-infected/transfected cells suggested that core protein pVII localizes to the mitochondria and contains a functional mitochondrial localization signal. Moreover, mitochondrial localization of BAdV-3 pVII appears to help in the retention of mitochondrial Ca(2+), inducing a significant increase in the levels of ATP and maintaining the mitochondrial membrane potential (MMP) in transfected cells. In contrast, mitochondrial localization of BAdV-3 pVII has no significant effect on the levels of cytoplasmic Ca(2+) and reactive oxygen species production in the transfected cells. Consistent with these results, expression of pVII in transfected cells treated with staurosporine decreased significantly the activation of caspase-3. Our results suggested that BAdV-3 pVII localizes to mitochondria, and interferes with apoptosis by inhibiting loss of the MMP and by increasing mitochondrial Ca(2+) and ATP production.

  7. Spacecraft particulate sizing spectrometer

    NASA Technical Reports Server (NTRS)

    Miranda, Henry A., Jr.

    1992-01-01

    An evaluation prototype device is described, together with conclusions and several recommendations for follow-on flight hardware. The device detects individual particles crossing an external sensing zone, and produces a histogram displaying the size distribution of particles sensed, over the nominal range of 5 to 50 microns. The output is totally independent of the particle refractive index, and is also largely unaffected by particle shape. The reported diameters are in terms of the equivalent sphere, as judged by the scattered light intercepted by the receiving channels, which develop signals whenever a particle crosses the beam of illumination in the sensing zone. Supporting evidence for the latter assertion is discussed on the basis of experimental test data for non-spherical particulates. Also included is a technical appendix which presents theoretical arguments that provide a firm foundation for this assertion.

  8. Developing Performance Cost Index Targets for ASHRAE Standard 90.1 Appendix G – Performance Rating Method

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rosenberg, Michael I.; Hart, Philip R.

    2016-02-16

    Appendix G, the Performance Rating Method in ASHRAE Standard 90.1 has been updated to make two significant changes for the 2016 edition, to be published in October of 2016. First, it allows Appendix G to be used as a third path for compliance with the standard in addition to rating beyond code building performance. This prevents modelers from having to develop separate building models for code compliance and beyond code programs. Using this new version of Appendix G to show compliance with the 2016 edition of the standard, the proposed building design needs to have a performance cost index (PCI)more » less than targets shown in a new table based on building type and climate zone. The second change is that the baseline design is now fixed at a stable level of performance set approximately equal to the 2004 code. Rather than changing the stringency of the baseline with each subsequent edition of the standard, compliance with new editions will simply require a reduced PCI (a PCI of zero is a net-zero building). Using this approach, buildings of any era can be rated using the same method. The intent is that any building energy code or beyond code program can use this methodology and merely set the appropriate PCI target for their needs. This report discusses the process used to set performance criteria for compliance with ASHRAE Standard 90.1-2016 and suggests a method for demonstrating compliance with other codes and beyond code programs.« less

  9. Developing Performance Cost Index Targets for ASHRAE Standard 90.1 Appendix G – Performance Rating Method - Rev.1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rosenberg, Michael I.; Hart, Philip R.

    2016-03-01

    Appendix G, the Performance Rating Method in ASHRAE Standard 90.1 has been updated to make two significant changes for the 2016 edition, to be published in October of 2016. First, it allows Appendix G to be used as a third path for compliance with the standard in addition to rating beyond code building performance. This prevents modelers from having to develop separate building models for code compliance and beyond code programs. Using this new version of Appendix G to show compliance with the 2016 edition of the standard, the proposed building design needs to have a performance cost index (PCI)more » less than targets shown in a new table based on building type and climate zone. The second change is that the baseline design is now fixed at a stable level of performance set approximately equal to the 2004 code. Rather than changing the stringency of the baseline with each subsequent edition of the standard, compliance with new editions will simply require a reduced PCI (a PCI of zero is a net-zero building). Using this approach, buildings of any era can be rated using the same method. The intent is that any building energy code or beyond code program can use this methodology and merely set the appropriate PCI target for their needs. This report discusses the process used to set performance criteria for compliance with ASHRAE Standard 90.1-2016 and suggests a method for demonstrating compliance with other codes and beyond code programs.« less

  10. Treatment of lysosomal storage disease in MPS VII mice using a recombinant adeno-associated virus.

    PubMed

    Watson, G L; Sayles, J N; Chen, C; Elliger, S S; Elliger, C A; Raju, N R; Kurtzman, G J; Podsakoff, G M

    1998-12-01

    Mucopolysaccharidosis type VII (MPS VII) is a lysosomal storage disease caused by a genetic deficiency of beta-glucuronidase (GUS). We used a recombinant adeno-associated virus vector (AAV-GUS) to deliver GUS cDNA to MPS VII mice. The route of vector administration had a dramatic effect on the extent and distribution of GUS activity. Intramuscular injection of AAV-GUS resulted in high, localized production of GUS, while intravenous administration produced low GUS activity in several tissues. This latter treatment of MPS VII mice reduced glycosaminoglycan levels in the liver to normal and reduced storage granules dramatically. We show that a single administration of AAV-GUS can provide sustained expression of GUS in a variety of cell types and is sufficient to reverse the disease phenotype at least in the liver.

  11. Effective treatment of chemoresistant breast cancer in vitro and in vivo by a factor VII-targeted photodynamic therapy.

    PubMed

    Duanmu, J; Cheng, J; Xu, J; Booth, C J; Hu, Z

    2011-04-26

    The purpose of this study was to test a novel, dual tumour vascular endothelial cell (VEC)- and tumour cell-targeting factor VII-targeted Sn(IV) chlorin e6 photodynamic therapy (fVII-tPDT) by targeting a receptor tissue factor (TF) as an alternative treatment for chemoresistant breast cancer using a multidrug resistant (MDR) breast cancer line MCF-7/MDR. The TF expression by the MCF-7/MDR breast cancer cells and tumour VECs in MCF-7/MDR tumours from mice was determined separately by flow cytometry and immunohistochemistry using anti-human or anti-murine TF antibodies. The efficacy of fVII-tPDT was tested in vitro and in vivo and was compared with non-targeted PDT for treatment of chemoresistant breast cancer. The in vitro efficacy was determined by a non-clonogenic assay using crystal violet staining for monolayers, and apoptosis and necrosis were assayed to elucidate the underlying mechanisms. The in vivo efficacy of fVII-tPDT was determined in a nude mouse model of subcutaneous MCF-7/MDR tumour xenograft by measuring tumour volume. To our knowledge, this is the first presentation showing that TF was expressed on tumour VECs in chemoresistant breast tumours from mice. The in vitro efficacy of fVII-tPDT was 12-fold stronger than that of ntPDT for MCF-7/MDR cancer cells, and the mechanism of action involved induction of apoptosis and necrosis. Moreover, fVII-tPDT was effective and safe for the treatment of chemoresistant breast tumours in the nude mouse model. We conclude that fVII-tPDT is effective and safe for the treatment of chemoresistant breast cancer, presumably by simultaneously targeting both the tumour neovasculature and chemoresistant cancer cells. Thus, this dual-targeting fVII-tPDT could also have therapeutic potential for the treatment of other chemoresistant cancers.

  12. The Plant Cysteine Oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors.

    PubMed

    White, Mark D; Kamps, Jos J A G; East, Samuel; Taylor Kearney, Leah J; Flashman, Emily

    2018-05-30

    Group VII Ethylene Response Factors (ERF-VIIs) regulate transcriptional adaptation to flooding-induced hypoxia in plants. ERF-VII stability is controlled in an O 2 -dependent manner by the Cys/Arg branch of the N-end rule pathway, whereby oxidation of a conserved N-terminal cysteine residue initiates target degradation. This oxidation is catalyzed by Plant Cysteine Oxidases (PCOs) which use O 2 as co-substrate to generate Cys-sulfinic acid. The PCOs directly link O2 availability to ERF-VII stability and anaerobic adaptation leading to the suggestion that they act as plant O 2 sensors. However, their ability to respond to fluctuations in O 2 concentration has not been established. Here, we investigated the steady-state kinetics of Arabidopsis thaliana PCOs 1-5 to ascertain whether their activities are sensitive to O 2 levels. We found that the most catalytically competent isoform is AtPCO4, in terms of both responding to O 2 , and oxidizing At RAP2.2 and 2.12, two of the primary hypoxic response activating ERF-VIIs; these data suggest that AtPCO4 plays a central role in ERF-VII regulation. Furthermore, we found that AtPCO activity is susceptible to decreases in pH and that the hypoxia-inducible AtPCOs 1/2 and the non-inducible AtPCOs 4/5 have discrete AtERF-VII substrate preferences. Pertinently, the AtPCOs had K m app (O 2 ) values in a physiologically relevant range, which should enable them to sensitively react to changes in O 2 availability. This work validates an O 2 -sensing role for the PCOs and suggests that differences in expression pattern, ERF-VII selectivity and catalytic capability may enable the different isoforms to have distinct biological functions. Individual PCOs could therefore be targeted to manipulate ERF-VII levels and improve stress tolerance in plants. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.

  13. Newly diagnosed congenital factor VII deficiency and utilization of recombinant activated factor VII (NovoSeven®)

    PubMed Central

    Bartosh, Nicole S; Tomlin, Tara; Cable, Christian; Halka, Kathleen

    2013-01-01

    This case report presents a newly diagnosed congenital factor VII deficiency treated with recombinant activated factor VII (rFVIIa). Congenital factor VII deficiency is a rare autosomal-recessive bleeding disorder that occurs in fewer than 1/500,000 persons. Its presentation can vary from epistaxis to hemarthroses and severe central nervous system bleeding, and correlates poorly with factor VII levels. Our patient had not had a significant hemostatic challenge prior to his presentation and therefore never had any symptomatology suggestive of this disease. He was treated with rFVIIa, and was able to undergo repair of his fractures without bleeding. Case report A 19-year-old African-American male presented to the emergency room after an altercation that resulted in significant trauma. He sustained bilateral mandibular angle fractures and orbital floor fractures, requiring urgent surgical correction. On initial evaluation, he was noted to have a prolonged prothrombin time of 40.1 seconds, with an International Normalized Ratio of 4.0, a normal activated partial thromboplastin time of 29.9 seconds, and a platelet count of 241. After receiving vitamin K and fresh frozen plasma, he was taken to the operating room for a temporary rigid maxillomandibular fixation. A 1:1 mixing study with normal plasma corrected the prothrombin time (decreasing from 40.7 to 14.7 seconds) and a factor VII assay revealed 5% of the normal factor VII level. The patient was diagnosed with congenital factor VII deficiency. Due to his coagulopathy and the extensive surgical correction needed, rFVIIa was administered and surgery was accomplished without hemorrhagic sequelae. Conclusion This case report and review describes a rare congenital disease, the history of rFVIIa use, and its mechanism. rFVIIA use in our patient provided a treatment option that allowed the necessary surgical correction, but further prospective studies on dose optimization would ensure adequate dosing with minimal risk of severe side effects. PMID:23516010

  14. Newly diagnosed congenital factor VII deficiency and utilization of recombinant activated factor VII (NovoSeven(®)).

    PubMed

    Bartosh, Nicole S; Tomlin, Tara; Cable, Christian; Halka, Kathleen

    2013-01-01

    This case report presents a newly diagnosed congenital factor VII deficiency treated with recombinant activated factor VII (rFVIIa). Congenital factor VII deficiency is a rare autosomal-recessive bleeding disorder that occurs in fewer than 1/500,000 persons. Its presentation can vary from epistaxis to hemarthroses and severe central nervous system bleeding, and correlates poorly with factor VII levels. Our patient had not had a significant hemostatic challenge prior to his presentation and therefore never had any symptomatology suggestive of this disease. He was treated with rFVIIa, and was able to undergo repair of his fractures without bleeding. A 19-year-old African-American male presented to the emergency room after an altercation that resulted in significant trauma. He sustained bilateral mandibular angle fractures and orbital floor fractures, requiring urgent surgical correction. On initial evaluation, he was noted to have a prolonged prothrombin time of 40.1 seconds, with an International Normalized Ratio of 4.0, a normal activated partial thromboplastin time of 29.9 seconds, and a platelet count of 241. After receiving vitamin K and fresh frozen plasma, he was taken to the operating room for a temporary rigid maxillomandibular fixation. A 1:1 mixing study with normal plasma corrected the prothrombin time (decreasing from 40.7 to 14.7 seconds) and a factor VII assay revealed 5% of the normal factor VII level. The patient was diagnosed with congenital factor VII deficiency. Due to his coagulopathy and the extensive surgical correction needed, rFVIIa was administered and surgery was accomplished without hemorrhagic sequelae. This case report and review describes a rare congenital disease, the history of rFVIIa use, and its mechanism. rFVIIA use in our patient provided a treatment option that allowed the necessary surgical correction, but further prospective studies on dose optimization would ensure adequate dosing with minimal risk of severe side effects.

  15. Anatomic Variability of the Upper Mediastinal Lymph Node Level VII.

    PubMed

    Hartl, Dana M; Breuskin, Ingrid; Mirghani, Haïtham; Berdelou, Amandine; Déandréis, Désirée; Pottier, Edwige; Borget, Isabelle; Schlumberger, Martin; Leboulleux, Sophie

    2016-08-01

    Lymph node level VII, between the sternal notch and the innominate artery, is a frequent site of lymph node metastases in thyroid cancer. The objective of this study was to determine the cranial-caudal dimensions of level VII in patients undergoing central neck dissection for thyroid cancer and its accessibility through a neck incision only. Consecutive patients undergoing central neck dissection for thyroid cancer, with no previous neck dissection, mediastinal or thoracic surgery. The innominate artery was identified and the distance between the sternal notch and the upper border of the artery was measured to the nearest .5 mm. The sizes of level VII were compared with respect to age, sex, height, body mass index, type of neck dissection (therapeutic or prophylactic), and the incidence of previous thyroidectomy. One-hundred-one consecutive patients (65 women, 36 men, mean age 44 years (range 15-87) underwent prophylactic (n = 55) or therapeutic (n = 46) bilateral central compartment neck dissection. Level VII was accessible via the horizontal neck incision in all cases. Sizes of level VII ranged from 6 cm above the sternal notch to 35 mm below the sternal notch, with a mean distance of 3.5 mm below the sternal notch. The innominate artery was at the level of the sternal notch in 29 patients, and cranial to the sternal notch in 20 cases. No statistical relationship with age, sex, therapeutic/prophylactic neck dissection, previous surgery, body mass index or height was found. The maximal distance below the sternal notch was 35 mm. Level VII did not exist in 49 % of patients, and was less than 25 mm caudal to the sternal notch in 95 % of cases. Distinguishing level VII from level VI in thyroid cancer surgery may not be pertinent, due to the ease of access via a classic horizontal neck incision and the small sizes of level VII in the majority of patients.

  16. Gulf Coast Water Port Facilities Study. Appendix A. Western Gulf Hydrobiological Zones.

    DTIC Science & Technology

    1973-04-01

    canals and A-1 I Arthur D) Lttle. Inc- t.L 0 ~ * IA-2 ArhrDxjte n 4- channels, and satellite industries. As Fisher et al. (1972) point out, the...Christi Causeway to Padre Island. Thus, the principal value of the artificial channels and passes (so long as the latter have remained open) provides...larvae pass to the lagoonal waters where they feed and grow to maturity. Copulation takes place in the estuarine waters. but the inseminated females

  17. United States Air Force F-35A Operational Basing Environmental Impact Statement. Appendix E: Responses

    DTIC Science & Technology

    2013-09-01

    R0287, R0549, R0662, R0740 Concerned that the afterburner was not factored into the noise zone equation. Afterburner takeoffs were factored into...the noise assessment. The F-35s at Burlington International Airport are proposed to use afterburners on only 5 percent of their takeoffs (vice the...90 percent done now by F-16s). However, the afterburner would be turned off shortly after the aircraft becomes airborne, much prior to crossing the

  18. 19 CFR Appendix to Part 146 - Guidelines for Determining Producibility and Relative Values for Oil Refinery Zones

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... × .20). Likewise, the class IV crude oil could produce aviation gasoline in an amount up to 8,500 pounds... Class III PF Crude 35,000 24,500 31,850 14,000 31,150 10,150 Class III D Crude 20,000 14,000 18,200 8,000 17,800 5,800 Class III NPF Crude 20,000 14,000 18,200 8,000 17,800 5,800 Feedstock factors are...

  19. 19 CFR Appendix to Part 146 - Guidelines for Determining Producibility and Relative Values for Oil Refinery Zones

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... × .20). Likewise, the class IV crude oil could produce aviation gasoline in an amount up to 8,500 pounds... Class III PF Crude 35,000 24,500 31,850 14,000 31,150 10,150 Class III D Crude 20,000 14,000 18,200 8,000 17,800 5,800 Class III NPF Crude 20,000 14,000 18,200 8,000 17,800 5,800 Feedstock factors are...

  20. A product Pearson-type VII density distribution

    NASA Astrophysics Data System (ADS)

    Nadarajah, Saralees; Kotz, Samuel

    2008-01-01

    The Pearson-type VII distributions (containing the Student's t distributions) are becoming increasing prominent and are being considered as competitors to the normal distribution. Motivated by real examples in decision sciences, Bayesian statistics, probability theory and Physics, a new Pearson-type VII distribution is introduced by taking the product of two Pearson-type VII pdfs. Various structural properties of this distribution are derived, including its cdf, moments, mean deviation about the mean, mean deviation about the median, entropy, asymptotic distribution of the extreme order statistics, maximum likelihood estimates and the Fisher information matrix. Finally, an application to a Bayesian testing problem is illustrated.

  1. Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells.

    PubMed

    Yokota, N; Koizume, S; Miyagi, E; Hirahara, F; Nakamura, Y; Kikuchi, K; Ruf, W; Sakuma, Y; Tsuchiya, E; Miyagi, Y

    2009-12-15

    Thromboembolic events are a major complication in ovarian cancer patients. Tissue factor (TF) is frequently overexpressed in ovarian cancer tissue and correlates with intravascular thrombosis. TF binds to coagulation factor VII (fVII), changing it to its active form, fVIIa. This leads to activation of the extrinsic coagulation cascade. fVII is produced by the liver and believed to be supplied from blood plasma at the site of coagulation. However, we recently showed that ovarian cancer cells express fVII transcripts under normoxia and that this transcription is inducible under hypoxia. These findings led us to hypothesise that ovarian cancer cells are intrinsically associated with TF-fVIIa coagulation activity, which could result in thrombosis. In this study, we examined whether ectopically expressed fVII could cause thrombosis by means of immunohistochemistry, RT-PCR, western blotting and flow cytometry. Ectopic fVII expression occurs frequently in ovarian cancers, particularly in clear cell carcinoma. We further showed that ovarian cancer cells express TF-fVIIa on the cell surface under normoxia and that this procoagulant activity is enhanced by hypoxic stimuli. Moreover, we showed that ovarian cancer cells secrete microparticles (MPs) with TF-fVIIa activity. Production of this procoagulant secretion is enhanced under hypoxia. These results raise the possibility that cancer cell-derived TF-fVIIa could cause thrombotic events in ovarian cancer patients.

  2. 29 CFR 1605.2 - Reasonable accommodation without undue hardship as required by section 701(j) of title VII of the...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GUIDELINES ON DISCRIMINATION... address other obligations under title VII not to discriminate on grounds of religion, nor other provisions... to discrimination prohibited by title VII on the bases of race, color, sex, and national origin also...

  3. 29 CFR 1604.8 - Relationship of title VII to the Equal Pay Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Relationship of title VII to the Equal Pay Act. 1604.8 Section 1604.8 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GUIDELINES ON DISCRIMINATION BECAUSE OF SEX § 1604.8 Relationship of title VII to the Equal Pay Act. (a) The...

  4. 29 CFR 1605.2 - Reasonable accommodation without undue hardship as required by section 701(j) of title VII of the...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GUIDELINES ON DISCRIMINATION... address other obligations under title VII not to discriminate on grounds of religion, nor other provisions... to discrimination prohibited by title VII on the bases of race, color, sex, and national origin also...

  5. 29 CFR 1604.8 - Relationship of title VII to the Equal Pay Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 4 2012-07-01 2012-07-01 false Relationship of title VII to the Equal Pay Act. 1604.8 Section 1604.8 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GUIDELINES ON DISCRIMINATION BECAUSE OF SEX § 1604.8 Relationship of title VII to the Equal Pay Act. (a) The...

  6. 29 CFR 1604.8 - Relationship of title VII to the Equal Pay Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 4 2013-07-01 2013-07-01 false Relationship of title VII to the Equal Pay Act. 1604.8 Section 1604.8 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GUIDELINES ON DISCRIMINATION BECAUSE OF SEX § 1604.8 Relationship of title VII to the Equal Pay Act. (a) The...

  7. 29 CFR 1604.8 - Relationship of title VII to the Equal Pay Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 4 2011-07-01 2011-07-01 false Relationship of title VII to the Equal Pay Act. 1604.8 Section 1604.8 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GUIDELINES ON DISCRIMINATION BECAUSE OF SEX § 1604.8 Relationship of title VII to the Equal Pay Act. (a) The...

  8. 29 CFR 1605.2 - Reasonable accommodation without undue hardship as required by section 701(j) of title VII of the...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GUIDELINES ON DISCRIMINATION... address other obligations under title VII not to discriminate on grounds of religion, nor other provisions... to discrimination prohibited by title VII on the bases of race, color, sex, and national origin also...

  9. 29 CFR 1605.2 - Reasonable accommodation without undue hardship as required by section 701(j) of title VII of the...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GUIDELINES ON DISCRIMINATION... address other obligations under title VII not to discriminate on grounds of religion, nor other provisions... to discrimination prohibited by title VII on the bases of race, color, sex, and national origin also...

  10. Turning Back the Title VII Clock: The Resegregation of the American Work Force through Validity Generalization.

    ERIC Educational Resources Information Center

    Goldstein, Barry L.; Patterson, Patrick O.

    1988-01-01

    Refers to Title VII of the Civil Rights Act of 1964 and the Supreme Court's disparate impact interpretation of Title VII in Griggs versus Duke Power Company. Contends that attacks on the Griggs decision are legally unsound and that claims made by advocates of validity generalization are scientifically unsupported. (Author/NB)

  11. Title VII Sexual Harassment Guidelines and Educational Employment [and] What Can Students Do About Sex Discrimination?

    ERIC Educational Resources Information Center

    Howard, Susan; And Others

    Guidelines concerning sexual harassment of employees at educational institutions under Title VII of the Civil Rights Act of 1964 are considered. November 1980 final interpretive guidelines issued by the Equal Employment Opportunity Commission state that Title VII prohibits sexual harassment of employees, that employers are responsible for the…

  12. Survey of Land-Grant Colleges and Universities. Bulletin, 1930, No. 9. Volume II. [Part VII - Index

    ERIC Educational Resources Information Center

    Office of Education, United States Department of the Interior, 1930

    1930-01-01

    The attached document covers the concluding sections of the second volume of the Survey of Land-Grant Colleges and Universities: Part VII through the index. Part VII, Extension services, is divided into the following sections: (1) Introduction; (2) Position and objectives of Smith-Lever cooperative extension; (3) Administrative organization of…

  13. 75 FR 67416 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ... Clerical and Grammatical Corrections to Chapter VII, Section 1 (Exercise of Options Contracts) of the... (``BOX'') to make a clerical correction to Chapter VII, Section 1 (Exercise of Options Contracts) of the... Exchange is proposing to make a clerical correction to the rule text of Chapter VII, Section 1 (Exercise of...

  14. Underuse of Title VII Funding for Indian Education in Arizona, Nevada, and Utah

    ERIC Educational Resources Information Center

    West Comprehensive Center at WestEd, 2015

    2015-01-01

    Title VII provides funding for the education of American Indian/Alaska Native students based on a formula grant available to school districts, charter schools, and local education agencies (LEAs). This report explores why some eligible schools and districts do not apply for federal Title VII, potentially resulting in American Indian/Alaska Native…

  15. 77 FR 61753 - Granting of Request for Early Termination of the Waiting Period Under the Premerger Notification...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-11

    ..., Inc.; Astria Semiconductor Holdings, Inc.; FormFactor, Inc. 20121365 G ABRY Partners VII, L.P.; Source.... 20121303 G Wind Point Partners L.P.; Mistral Equity Partners, LP; Wind Point Partners VII-A, L.P. 20121307... Dillard. 20121364 G Apollo Investment Fund VII, L.P.; Jimmy Sanders Incorporated; Apollo Investment Fund...

  16. 78 FR 34545 - Prohibition Against Federal Assistance to Swaps Entities (Regulation KK)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ...) only, call (202) 263- 4869. SUPPLEMENTARY INFORMATION: Section 716 of Title VII of the Dodd-Frank Wall... agencies to enforce compliance with laws such as Title VII of the Dodd-Frank Act against uninsured U.S... 716 and Title VII of the Dodd-Frank Act generally are intended to reduce systemic risks from...

  17. Managing Information Technology: Facing the Issues. Track VII: Applications and Technology Issues.

    ERIC Educational Resources Information Center

    CAUSE, Boulder, CO.

    Eight papers making up Track VII of the 1989 conference of the Professional Association for the Management of Information Technology in Higher Education (known as CAUSE, an acronym of the association's former name) are presented in this document. The focus of Track VII is on applications and technology issues, and the papers include: "The…

  18. Human Adenovirus Infection Causes Cellular E3 Ubiquitin Ligase MKRN1 Degradation Involving the Viral Core Protein pVII.

    PubMed

    Inturi, Raviteja; Mun, Kwangchol; Singethan, Katrin; Schreiner, Sabrina; Punga, Tanel

    2018-02-01

    Human adenoviruses (HAdVs) are common human pathogens encoding a highly abundant histone-like core protein, VII, which is involved in nuclear delivery and protection of viral DNA as well as in sequestering immune danger signals in infected cells. The molecular details of how protein VII acts as a multifunctional protein have remained to a large extent enigmatic. Here we report the identification of several cellular proteins interacting with the precursor pVII protein. We show that the cellular E3 ubiquitin ligase MKRN1 is a novel precursor pVII-interacting protein in HAdV-C5-infected cells. Surprisingly, the endogenous MKRN1 protein underwent proteasomal degradation during the late phase of HAdV-C5 infection in various human cell lines. MKRN1 protein degradation occurred independently of the HAdV E1B55K and E4orf6 proteins. We provide experimental evidence that the precursor pVII protein binding enhances MKRN1 self-ubiquitination, whereas the processed mature VII protein is deficient in this function. Based on these data, we propose that the pVII protein binding promotes MKRN1 self-ubiquitination, followed by proteasomal degradation of the MKRN1 protein, in HAdV-C5-infected cells. In addition, we show that measles virus and vesicular stomatitis virus infections reduce the MKRN1 protein accumulation in the recipient cells. Taken together, our results expand the functional repertoire of the HAdV-C5 precursor pVII protein in lytic virus infection and highlight MKRN1 as a potential common target during different virus infections. IMPORTANCE Human adenoviruses (HAdVs) are common pathogens causing a wide range of diseases. To achieve pathogenicity, HAdVs have to counteract a variety of host cell antiviral defense systems, which would otherwise hamper virus replication. In this study, we show that the HAdV-C5 histone-like core protein pVII binds to and promotes self-ubiquitination of a cellular E3 ubiquitin ligase named MKRN1. This mutual interaction between the pVII and MKRN1 proteins may prime MKRN1 for proteasomal degradation, because the MKRN1 protein is efficiently degraded during the late phase of HAdV-C5 infection. Since MKRN1 protein accumulation is also reduced in measles virus- and vesicular stomatitis virus-infected cells, our results signify the general strategy of viruses to target MKRN1. Copyright © 2018 American Society for Microbiology.

  19. Heptavalent Neptunium in a Gas-Phase Complex: (Np VIIO 3 +)(NO 3 –) 2

    DOE PAGES

    Dau, Phuong D.; Maurice, Remi; Renault, Eric; ...

    2016-09-15

    A central goal of chemistry is to achieve ultimate oxidation states, including in gas-phase complexes with no condensed phase perturbations. In the case of the actinide elements, the highest established oxidation states are labile Pu(VII) and somewhat more stable Np(VII). We have synthesized and characterized gas-phase AnO 3(NO 3) 2- complexes for An = U, Np, and Pu by endothermic NO 2 elimination from AnO 2(NO 3) 3-. It was previously demonstrated that the PuO 3+ core of PuO 3(NO 3) 2- has a Pu—O• radical bond such that the oxidation state is Pu(VI); it follows that in UO 3(NOmore » 3) 2- it is the stable U(VI) oxidation state. On the basis of the relatively more facile synthesis of NpO 3(NO 3) 2-, a Np(VII) oxidation state is inferred. This interpretation is substantiated by reactivity of the three complexes: NO 2 spontaneously adds to UO 3(NO 3) 2- and PuO 3(NO 3) 2- but not to NpO 3(NO 3) 2-. This unreactive character is attributed to a Np(VII)O 3+ core with three stable Np=O bonds, this in contrast to reactive U—O• and Pu—O• radical bonds. The computed structures and reaction energies for the three AnO 3(NO 3) 2- support the conclusion that the oxidation states are U(VI), Np(VII), and Pu(VI). These results establish the extreme Np(VII) oxidation state in a gas-phase complex, and demonstrate the inherently greater stability of Np(VII) versus Pu(VII).« less

  20. Radiographic Evaluation of Bones and Joints in Mucopolysaccharidosis I and VII Dogs After Neonatal Gene Therapy

    PubMed Central

    Herati, Ramin Sedaghat; Knox, Van W.; O’Donnell, Patricia; D’Angelo, Marina; Haskins, Mark E.; Ponder, Katherine P.

    2009-01-01

    Mucopolysaccharidosis I (MPS I) and MPS VII are due to deficient activity of the glycosaminoglycan-degrading lysosomal enzymes α-L-iduronidase and β-glucuronidase, respectively, and result in abnormal bones and joints. Here, the severity of skeletal disease in MPS I and MPS VII dogs and the effects of neonatal gene therapy were evaluated. For untreated MPS VII dogs, the lengths of the second cervical vertebrae (C2) and the femur were only 56% and 84% of normal, respectively, and bone dysplasia and articular erosions, and joint subluxation were severe. Previously, we reported that neonatal intravenous injection of a retroviral vector (RV) with the appropriate gene resulted in expression in liver and blood cells, and high serum enzyme activity. In this study, we demonstrate that C2 and femurs of RV-treated MPS VII dogs were longer at 82% and 101% of normal, respectively, and there were partial improvements of qualitative abnormalities. For untreated MPS I dogs, the lengths of C2 and femurs (91% and 96% of normal, respectively) were not significantly different from normal dogs. Qualitative changes in MPS I bones and joints were generally modest and were partially improved with RV treatment, although cervical spine disease was severe and was difficult to correct with gene therapy in both models. The greater severity of skeletal disease in MPS VII than in MPS I dogs may reflect accumulation of chondroitin sulfate in cartilage in MPS VII, or could relate to the specific mutations. Neonatal RV-mediated gene therapy ameliorates, but does not prevent, skeletal disease in MPS I and MPS VII dogs. PMID:18707908

  1. Anti-Type VII Collagen Antibodies Are Identified in a Subpopulation of Bullous Pemphigoid Patients With Relapse

    PubMed Central

    Giusti, Delphine; Gatouillat, Grégory; Le Jan, Sébastien; Plée, Julie; Bernard, Philippe; Antonicelli, Frank; Pham, Bach-Nga

    2018-01-01

    Bullous pemphigoid (BP) is an autoimmune bullous skin disease characterized by anti-BP180 and anti-BP230 autoantibodies (AAbs). Mucous membrane involvement is an uncommon clinical feature of BP which may evoke epidermolysis bullosa acquisita, another skin autoimmune disease characterized by anti-type VII collagen AAbs. We therefore evaluated the presence of anti-type VII collagen AAbs in the serum of BP patients with and without mucosal lesions at time of diagnosis and under therapy. Anti-BP180, anti-BP230, and anti-type VII collagen AAbs were measured by ELISA in the serum of unselected patients fulfilling clinical and histo/immunopathological BP criteria at baseline (n = 71) and at time of relapse (n = 24). At baseline, anti-type VII collagen AAbs were detected in 2 out of 24 patients with BP presenting with mucosal involvement, but not in patients without mucosal lesions (n = 47). At the time of relapse, 10 out of 24 BP patients either displayed a significant induction or increase of concentrations of anti-type VII collagen AAbs (P < 0.01), independently of mucosal involvement. Those 10 relapsing BP patients were also characterized by a sustained high concentration of anti-BP180 AAb, whereas the serum anti-BP230 AAb concentrations did not vary in BP patients with relapse according to the presence of anti-type VII collagen AAbs. Thus, our study showed that anti-type VII collagen along with anti-BP180 AAbs detection stratified BP patients at time of relapse, illustrating a still dysregulated immune response that could reflect a potential epitope spreading mechanism in those BP patients. PMID:29619029

  2. The adenovirus major core protein VII is dispensable for virion assembly but is essential for lytic infection

    PubMed Central

    Suomalainen, Maarit; Zheng, Yueting; Boucke, Karin

    2017-01-01

    The Adenovirus (Ad) genome within the capsid is tightly associated with a virus-encoded, histone-like core protein—protein VII. Two other Ad core proteins, V and X/μ, also are located within the virion and are loosely associated with viral DNA. Core protein VII remains associated with the Ad genome during the early phase of infection. It is not known if naked Ad DNA is packaged into the capsid, as with dsDNA bacteriophage and herpesviruses, followed by the encapsidation of viral core proteins, or if a unique packaging mechanism exists with Ad where a DNA-protein complex is simultaneously packaged into the virion. The latter model would require an entirely new molecular mechanism for packaging compared to known viral packaging motors. We characterized a virus with a conditional knockout of core protein VII. Remarkably, virus particles were assembled efficiently in the absence of protein VII. No changes in protein composition were evident with VII−virus particles, including the abundance of core protein V, but changes in the proteolytic processing of some capsid proteins were evident. Virus particles that lack protein VII enter the cell, but incoming virions did not escape efficiently from endosomes. This greatly diminished all subsequent aspects of the infectious cycle. These results reveal that the Ad major core protein VII is not required to condense viral DNA within the capsid, but rather plays an unexpected role during virus maturation and the early stages of infection. These results establish a new paradigm pertaining to the Ad assembly mechanism and reveal a new and important role of protein VII in early stages of infection. PMID:28628648

  3. Association of ACE and FACTOR VII gene variability with the risk of coronary heart disease in north Indian population.

    PubMed

    Sobti, R C; Maithil, Nishi; Thakur, Hitender; Sharma, Yashpaul; Talwar, K K

    2010-08-01

    The angiotensin converting enzyme (ACE) is a key factor in the production of angiotensin II and in the degradation of bradykinin. Chronic exposure to high levels of circulating and tissue ACE predispose to vascular wall thickening and atherosclerosis. Factor VII (FACTOR VII) is the first enzyme in the extrinsic pathway of the blood coagulation system and plays a key role in hemostasis; it also contributes to the occurrence of thrombotic events. In this study, we have examined the association of ACE and FACTOR VII gene in coronary heart disease patients (n = 300) and their age-matched controls (n = 300). Genotyping was done by PCR-RFLP method. No significant difference was observed in the distribution of I/D genotypes of ACE between cases and controls. In case of FACTOR VII R353Q polymorphism, there was not much difference in the distribution of alleles. AA genotype had protective effect for CHD (OR 0.56, 95% CI 0.37-0.83, P = 0.001). In case of FACTOR VII VNTR, there was difference in the distribution of alleles, H6 (73.5) and H7 (25.5) in cases, and H6 (70.5) and H7 (30.5) in controls. H6H7 and H7H7 genotypes had a protective effect for CHD with OR 0.27, 95% CI 0.18-0.41, P < 0.001, and OR 0.18, 95% CI 0.09-0.36, P < 0.001. Our study showed D allele of ACE to be associated with marginal risk of CHD, AA genotype of FACTOR VII R353Q and H6H7 and H7H7 genotypes of FACTOR VII VNTR showed protective effect for CHD.

  4. Administration of recombinant activated factor VII in the intensive care unit after complex cardiovascular surgery: clinical and economic outcomes.

    PubMed

    Uber, Walter E; Toole, John M; Stroud, Martha R; Haney, Jason S; Lazarchick, John; Crawford, Fred A; Ikonomidis, John S

    2011-06-01

    Refractory bleeding after complex cardiovascular surgery often leads to increased length of stay, cost, morbidity, and mortality. Recombinant activated factor VII administered in the intensive care unit can reduce bleeding, transfusion, and surgical re-exploration. We retrospectively compared factor VII administration in the intensive care unit with reoperation for refractory bleeding after complex cardiovascular surgery. From 1501 patients who underwent cardiovascular procedures between December 2003 and September 2007, 415 high-risk patients were identified. From this cohort, 24 patients were divided into 2 groups based on whether they either received factor VII in the intensive care unit (n = 12) or underwent reoperation (n = 12) for refractory bleeding. Preoperative and postoperative data were collected to compare efficacy, safety, and economic outcomes. In-hospital survival for both groups was 100%. Factor VII was comparable with reoperation in achieving hemostasis, with both groups demonstrating decreases in chest tube output and need for blood products. Freedom from reoperation was achieved in 75% of patients receiving factor VII, whereas reoperation was effective in achieving hemostasis alone in 83.3% of patients. Prothrombin time, international normalized ratio, and median operating room time were significantly less (P < .05) in patients who received factor VII. Both groups had no statistically significant differences in other efficacy, safety, or economic outcomes. Factor VII administration in the intensive care unit appears comparable with reoperation for refractory bleeding after complex cardiovascular surgical procedures and might represent an alternative to reoperation in selected patients. Future prospective, randomized controlled trials might further define its role. Copyright © 2011 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.

  5. Age-related changes in factor VII proteolysis in vivo.

    PubMed

    Ofosu, F A; Craven, S; Dewar, L; Anvari, N; Andrew, M; Blajchman, M A

    1996-08-01

    Previous studies have reported that pre-operative plasmas of patients over the age of 40 years who developed post-operative deep vein thrombosis (DVT) had approximately twice the amount of proteolysed factor VII found in plasmas of patients in whom prophylaxis with heparin or low M(r) heparin was successful. These and other studies also reported higher concentrations of thrombin-antithrombin III in pre- and post-operative plasmas of patients who developed post-operative thrombosis than in plasmas of patients in whom prophylaxis was successful. Whether the extent of factor VII proteolysis seen in the patients who developed post-operative DVT is related to the severity of their disease or age is not known. This report investigated age-related changes in the concentrations of total factor VII protein, factor VII zymogen, factor VIIa, tissue factor pathway inhibitor, thrombin-antithrombin III, and prothrombin fragment 1 + 2 in normal plasmas and the relationships between these parameters. With the exception of thrombin-antithrombin III, statistically significant increases in the concentrations of these parameters with age were found. Additionally, the differences between the concentrations of total factor VII protein and factor VII zymogen, an index factor VII proteolysis in vivo, were statistically significant only for individuals over age 40. Using linear regression analysis, a significant correlation was found to exist between the concentrations of plasma factor VIIa and prothrombin fragment 1 + 2. Since factor VIIa-tissue factor probably initiates coagulation in vivo, we hypothesize that the elevated plasma factor VIIa (reflecting a less tightly regulated tissue factor activity and therefore increased thrombin production in vivo) accounts for the high risk for post-operative thrombosis seen in individuals over the age of 40.

  6. Proposed re-evaluation of the 154Eu thermal ( n, γ) capture cross-section based on spent fuel benchmarking studies

    DOE PAGES

    Skutnik, Steven E.

    2016-09-22

    154Eu is a nuclide of considerable importance to both non-destructive measurements of used nuclear fuel assembly burnup as well as for calculating the radiation source term for used fuel storage and transportation. But, recent evidence from code validation studies of spent fuel benchmarks have revealed evidence of a systemic bias in predicted 154Eu inventories when using ENDF/B-VII.0 and ENDF/B-VII.1 nuclear data libraries, wherein Eu-154 is consistently over-predicted on the order of 10% or more. Further, this bias is found to correlate with sample burnup, resulting in a larger departure from experimental measurements for higher sample burnups. Here, the bias in Eu-154 is characterized across eleven spent fuel destructive assay benchmarks from five different assemblies. Based on these studies, possible amendments to the ENDF/B-VII.0 and VII.1 evaluations of the 154Eu (n,γ) 155Eu are explored. By amending the location of the first resolved resonance for the 154Eu radiative capture cross-section (centered at 0.195 eV in ENDF/B-VII.0 and VII.1) to 0.188 eV and adjusting the neutron capture width proportional tomore » $$\\sqrt1/E$$, the amended cross-section evaluation was found to reduce the bias in predicted 154Eu inventories by approximately 5–7%. And while the amended capture cross-section still results in a residual over-prediction of 154Eu (ranging from 2% to 9%), the effect is substantially attenuated compared with the nominal ENDF/B-VII.0 and VII.1 evaluations.« less

  7. Clinical course of sly syndrome (mucopolysaccharidosis type VII)

    PubMed Central

    Montaño, Adriana M; Lock-Hock, Ngu; Steiner, Robert D; Graham, Brett H; Szlago, Marina; Greenstein, Robert; Pineda, Mercedes; Gonzalez-Meneses, Antonio; Çoker, Mahmut; Bartholomew, Dennis; Sands, Mark S; Wang, Raymond; Giugliani, Roberto; Macaya, Alfons; Pastores, Gregory; Ketko, Anastasia K; Ezgü, Fatih; Tanaka, Akemi; Arash, Laila; Beck, Michael; Falk, Rena E; Bhattacharya, Kaustuv; Franco, José; White, Klane K; Mitchell, Grant A; Cimbalistiene, Loreta; Holtz, Max; Sly, William S

    2016-01-01

    Background Mucopolysaccharidosis VII (MPS VII) is an ultra-rare disease characterised by the deficiency of β-glucuronidase (GUS). Patients’ phenotypes vary from severe forms with hydrops fetalis, skeletal dysplasia and mental retardation to milder forms with fewer manifestations and mild skeletal abnormalities. Accurate assessments on the frequency and clinical characteristics of the disease have been scarce. The aim of this study was to collect such data. Methods We have conducted a survey of physicians to document the medical history of patients with MPS VII. The survey included anonymous information on patient demographics, family history, mode of diagnosis, age of onset, signs and symptoms, severity, management, clinical features and natural progression of the disease. Results We collected information on 56 patients from 11 countries. Patients with MPS VII were classified based on their phenotype into three different groups: (1) neonatal non-immune hydrops fetalis (NIHF) (n=10), (2) Infantile or adolescent form with history of hydrops fetalis (n=13) and (3) Infantile or adolescent form without known hydrops fetalis (n=33). Thirteen patients with MPS VII who had the infantile form with history of hydrops fetalis and survived childhood, had a wide range of clinical manifestations from mild to severe. Five patients underwent bone marrow transplantation and one patient underwent enzyme replacement therapy with recombinant human GUS. Conclusions MPS VII is a pan-ethnic inherited lysosomal storage disease with considerable phenotypical heterogeneity. Most patients have short stature, skeletal dysplasia, hepatosplenomegaly, hernias, cardiac involvement, pulmonary insufficiency and cognitive impairment. In these respects it resembles MPS I and MPS II. In MPS VII, however, one unique and distinguishing clinical feature is the unexpectedly high proportion of patients (41%) that had a history of NIHF. Presence of NIHF does not, by itself, predict the eventual severity of the clinical course, if the patient survives infancy. PMID:26908836

  8. Proposed re-evaluation of the 154Eu thermal ( n, γ) capture cross-section based on spent fuel benchmarking studies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Skutnik, Steven E.

    154Eu is a nuclide of considerable importance to both non-destructive measurements of used nuclear fuel assembly burnup as well as for calculating the radiation source term for used fuel storage and transportation. But, recent evidence from code validation studies of spent fuel benchmarks have revealed evidence of a systemic bias in predicted 154Eu inventories when using ENDF/B-VII.0 and ENDF/B-VII.1 nuclear data libraries, wherein Eu-154 is consistently over-predicted on the order of 10% or more. Further, this bias is found to correlate with sample burnup, resulting in a larger departure from experimental measurements for higher sample burnups. Here, the bias in Eu-154 is characterized across eleven spent fuel destructive assay benchmarks from five different assemblies. Based on these studies, possible amendments to the ENDF/B-VII.0 and VII.1 evaluations of the 154Eu (n,γ) 155Eu are explored. By amending the location of the first resolved resonance for the 154Eu radiative capture cross-section (centered at 0.195 eV in ENDF/B-VII.0 and VII.1) to 0.188 eV and adjusting the neutron capture width proportional tomore » $$\\sqrt1/E$$, the amended cross-section evaluation was found to reduce the bias in predicted 154Eu inventories by approximately 5–7%. And while the amended capture cross-section still results in a residual over-prediction of 154Eu (ranging from 2% to 9%), the effect is substantially attenuated compared with the nominal ENDF/B-VII.0 and VII.1 evaluations.« less

  9. Finite element models of earthquake cycles in mature strike-slip fault zones

    NASA Astrophysics Data System (ADS)

    Lynch, John Charles

    The research presented in this dissertation is on the subject of strike-slip earthquakes and the stresses that build and release in the Earth's crust during earthquake cycles. Numerical models of these cycles in a layered elastic/viscoelastic crust are produced using the finite element method. A fault that alternately sticks and slips poses a particularly challenging problem for numerical implementation, and a new contact element dubbed the "Velcro" element was developed to address this problem (Appendix A). Additionally, the finite element code used in this study was bench-marked against analytical solutions for some simplified problems (Chapter 2), and the resolving power was tested for the fault region of the models (Appendix B). With the modeling method thus developed, there are two main questions posed. First, in Chapter 3, the effect of a finite-width shear zone is considered. By defining a viscoelastic shear zone beneath a periodically slipping fault, it is found that shear stress concentrates at the edges of the shear zone and thus causes the stress tensor to rotate into non-Andersonian orientations. Several methods are used to examine the stress patterns, including the plunge angles of the principal stresses and a new method that plots the stress tensor in a manner analogous to seismic focal mechanism diagrams. In Chapter 4, a simple San Andreas-like model is constructed, consisting of two great earthquake producing faults separated by a freely-slipping shorter fault. The model inputs of lower crustal viscosity, fault separation distance, and relative breaking strengths are examined for their effect on fault communication. It is found that with a lower crustal viscosity of 1018 Pa s (in the lower range of estimates for California), the two faults tend to synchronize their earthquake cycles, even in the cases where the faults have asymmetric breaking strengths. These models imply that postseismic stress transfer over hundreds of kilometers may play a significant roll in the variability of earthquake repeat times. Specifically, small perturbations in the model parameters can lead to results similar to such observed phenomena as earthquake clustering and disruptions to so-called "characteristic" earthquake cycles.

  10. 42 CFR 57.1507 - Limitations applicable to loan guarantee.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... factors consistent with the purpose of part B of title VII of the Act and this subpart. (3) In determining... under part B of title VII of the Act or any other law of the United States, or to the total of such... part B of title VII of the Act. In making such determinations, the Secretary will in each case consider...

  11. 8 CFR 233.6 - Aliens entering Guam or the Commonwealth of the Northern Mariana Islands pursuant to Title VII of...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, âConsolidated Natural Resources Act of 2008.â 233.6 Section 233.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY... of the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, “Consolidated Natural...

  12. 8 CFR 233.6 - Aliens entering Guam or the Commonwealth of the Northern Mariana Islands pursuant to Title VII of...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, âConsolidated Natural Resources Act of 2008.â 233.6 Section 233.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY... of the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, “Consolidated Natural...

  13. 8 CFR 233.6 - Aliens entering Guam or the Commonwealth of the Northern Mariana Islands pursuant to Title VII of...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, âConsolidated Natural Resources Act of 2008.â 233.6 Section 233.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY... of the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, “Consolidated Natural...

  14. 8 CFR 233.6 - Aliens entering Guam or the Commonwealth of the Northern Mariana Islands pursuant to Title VII of...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, âConsolidated Natural Resources Act of 2008.â 233.6 Section 233.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY... of the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, “Consolidated Natural...

  15. 8 CFR 233.6 - Aliens entering Guam or the Commonwealth of the Northern Mariana Islands pursuant to Title VII of...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, âConsolidated Natural Resources Act of 2008.â 233.6 Section 233.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY... of the Northern Mariana Islands pursuant to Title VII of Public Law 110-229, “Consolidated Natural...

  16. Onset of ice VII phase during ps laser pulse propagation through liquid water

    NASA Astrophysics Data System (ADS)

    Paturi, Prem Kiran; Vaddapally, Rakesh Kumar; Acrhem Team

    2015-06-01

    Water dominantly present in liquid state on earth gets transformed to crystalline polymorphs under different dynamic loading conditions. Out of 15 different crystalline phases discovered till date, ice VII is observed to be stable over wide pressure (2-63 GPa) and temperature (>273 K) ranges. We present the onset of ice VII phase at low threshold of 2 mJ/pulse during 30 ps (532 nm, 10 Hz) laser pulse induced shock propagating through liquid water. Role of input pulse energy on the evolution of Stoke's and anti-Stoke's Raman shift of the dominant A1g mode of ice VII, filamentation, free-electrons, plasma shielding is presented. The H-bond network rearrangement, electron ion energy transfer time coinciding with the excitation pulse duration supported by the filamentation and plasma shielding of the ps laser pulses reduced the threshold of ice VII structure formation. Filamentation and the plasma shielding have shown the localized creation and sustenance of ice VII structure in liquid water over 3 mm length and 50 μm area of cross-section. The work is supported by Defence Research and Developement Organization, India through Grants-in-Aid Program.

  17. Quantitative proteomics identify an association between extracellular matrix degradation and immunopathology of genotype VII Newcastle disease virus in the spleen in chickens.

    PubMed

    Hu, Zenglei; Gu, Han; Hu, Jiao; Hu, Shunlin; Wang, Xiaoquan; Liu, Xiaowen; Jiao, Xinan; Liu, Xiufan

    2018-06-15

    Pathogenesis of genotype VII Newcastle disease virus (NDV) is characterized with remarkable immunopathology in the spleen in chickens. However, the mechanism for this unique pathological phenotype is not fully understood. Previous transcriptomics data showed that genotype VII NDV JS5/05 caused a greater downregulation of extracellular matrix (ECM) genes than genotype IV virus Herts/33 in the spleen. In this study, the role of ECM in pathology of genotype VII NDV was investigated using quantitative proteomics. Pathology studies showed that JS5/05 caused severe immunopathology characterized with remarkable necrosis in the spleen, whereas Herts/33 only induced mild pathological changes. The ECM was firstly enriched from the spleens and ECM proteins of different categories were identified by LC-MS/MS. Quantitative proteomic analysis showed that JS5/05 caused a significant disruption of ECM integrity and molecular composition compared to Herts/33. Particularly, JS5/05 induced a more remarkable collagen breakdown in the spleen compared to Herts/33. Moreover, matrix metalloproteinase (MMP)-13 and -14 were significantly upregulated by JS5/05 infection. KEGG pathway analysis suggested that differential regulation of ECM proteins by JS5/05 and Herts/33 may impact pathology through different pathways. Therefore, our results suggested that MMP upregulation and consequent ECM degradation contribute to immunopathology of genotype VII NDV in the spleen. Pathogenesis of genotype VII NDV is characterized with severe immunopathology in the spleen in chickens. Elucidating the mechanism of this pathology phenotype is critical to understand pathogenesis of genotype VII NDV. Here, we present the proteomic data of an important non-cellular compartment, the extracellular matrix (ECM), in the spleen from chickens infected with genotype VII and IV NDVs. Our results suggest that significant upregulation of matrix metalloproteinases by genotype VII NDV and consequent disruption of ECM integrity and composition may be associated with immunopathology in the spleen. Moreover, ECM degradation, represented by collagen breakdown, is an important pathology event in the process of genotype VII NDV infection. Our study for the first time presents evidence of ECM regulation by NDV and adds ECM remodeling as a new manifestation for NDV pathology. Our findings also deepen the understanding of NDV pathogenesis. Copyright © 2018. Published by Elsevier B.V.

  18. Expanding the versatility of phage display I: efficient display of peptide-tags on protein VII of the filamentous phage.

    PubMed

    Løset, Geir Åge; Bogen, Bjarne; Sandlie, Inger

    2011-02-24

    Phage display is a platform for selection of specific binding molecules and this is a clear-cut motivation for increasing its performance. Polypeptides are normally displayed as fusions to the major coat protein VIII (pVIII), or the minor coat protein III (pIII). Display on other coat proteins such as pVII allows for display of heterologous peptide sequences on the virions in addition to those displayed on pIII and pVIII. In addition, pVII display is an alternative to pIII or pVIII display. Here we demonstrate how standard pIII or pVIII display phagemids are complemented with a helper phage which supports production of virions that are tagged with octa FLAG, HIS(6) or AviTag on pVII. The periplasmic signal sequence required for pIII and pVIII display, and which has been added to pVII in earlier studies, is omitted altogether. Tagging on pVII is an important and very useful add-on feature to standard pIII and pVII display. Any phagemid bearing a protein of interest on either pIII or pVIII can be tagged with any of the tags depending simply on choice of helper phage. We show in this paper how such tags may be utilized for immobilization and separation as well as purification and detection of monoclonal and polyclonal phage populations.

  19. REVIEW OF DRAFT REVISED BLUE BOOK ON ESTIMATING ...

    EPA Pesticide Factsheets

    In 1994, EPA published a report, referred to as the “Blue Book,” which lays out EPA’s current methodology for quantitatively estimating radiogenic cancer risks. A follow-on report made minor adjustments to the previous estimates and presented a partial analysis of the uncertainties in the numerical estimates. In 2006, the National Research Council of the National Academy of Sciences released a report on the health risks from exposure to low levels of ionizing radiation. Cosponsored by the EPA and several other Federal agencies, Health Risks from Exposure to Low Levels of Ionizing Radiation BEIR VII Phase 2 (BEIR VII) primarily addresses cancer and genetic risks from low doses of low-LET radiation. In the draft White Paper: Modifying EPA Radiation Risk Models Based on BEIR VII (White Paper), ORIA proposed changes in EPA’s methodology for estimating radiogenic cancers, based on the contents of BEIR VII and some ancillary information. For the most part, it proposed to adopt the models and methodology recommended in BEIR VII; however, certain modifications and expansions are considered to be desirable or necessary for EPA’s purposes. EPA sought advice from the Agency’s Science Advisory Board on the application of BEIR VII and on issues relating to these modifications and expansions in the Advisory on EPA’s Draft White Paper: Modifying EPA Radiation Risk Models Based on BEIR VII (record # 83044). The SAB issued its Advisory on Jan. 31, 2008 (EPA-SAB-08-

  20. Geophysical investigation of seamounts near the Ogasawara fracture zone, western Pacific

    USGS Publications Warehouse

    Lee, T.-G.; Lee, Kenneth; Hein, J.R.; Moon, J.-W.

    2009-01-01

    This paper provides an analysis of multi-channel seismic data obtained during 2000-2001 on seamounts near the Ogasawara Fracture Zone (OFZ) northwest of the Marshall Islands in the western Pacific. The OFZ is unique in that it is a wide rift zone that includes many seamounts. Seven units are delineated on the basis of acoustic characteristics and depth: three units (I, II, and III) on the summit of seamounts and four units (IV, V, VI, and VII) in basins. Acoustic characteristics of layers on the summit of guyots and dredged samples indicate that the seamounts had been built above sea level by volcanism. This was followed by reef growth along the summit margin, which enabled deposition of shallow-water carbonates on the summit, and finally by subsidence of the edifices. The subsidence depth of the seamounts, estimated from the lower boundary of unit II, ranges between 1,550 and 2,040 m. The thick unit I of the southern seamounts is correlated with proximity to the equatorial high productivity zone, whereas local currents may have strongly affected the distribution of unit I on northern seamounts. A seismic profile in the basin around the Ita Mai Tai and OSM4 seamounts shows an unconformity between units IV and V, which is widespread from the East Mariana Basin to the Pigafetta Basin. Copyright ?? The Society of Geomagnetism and Earth, Planetary and Space Sciences (SGEPSS); The Seismological Society of Japan; The Volcanological Society of Japan; The Geodetic Society of Japan; The Japanese Society for Planetary Sciences; TERRAPUB.

  1. Effects of Recombinant Activated Factor VII in Traumatic Nonsurgical Intracranial Hemorrhage

    DTIC Science & Technology

    2006-09-01

    with inhibitors to factors VIII and IX, and it is ap- proved in Europe for the treatment of patients with acquired hemophilia, congenital FVII deficiency...GARY P. WRATTEN SURGICAL SYMPOSIUM Effects of Recombinant Activated Factor VII in Traumatic Nonsurgical Intracranial Hemorrhage Christopher E. White...OBJECTIVE: To determine whether treatment with recombi- nant activated factor VII (rFVIIa) will prevent progression of bleeding in nonsurgical

  2. Hybrid Metal/Electrolyte Monolithic Low Temperature SOFCs

    DTIC Science & Technology

    2004-10-15

    Glasses , and Composites VII Ceramic Transactions, 154,131-140, (2003). 9. R. Oh, K. M. Hurysz, and J. K. Cochran, “Effects of Die Geometry and...Paste Rheology on Extrusion Pressure”, Innovative Processes/Synthesis: Ceramics, Glasses , and Composites VII, Ceramic Transactions, 154,153-163, (2003...Processes/Synthesis: Ceramics, Glasses , and Composites VII, Ceramic Transactions, 154, pp.165-175, (2003). 11. Jason H. Nadler, Thomas H. Sanders, Jr

  3. Case report: a 70-year-old man with undiagnosed factor VII deficiency presented with acute ischemic stroke.

    PubMed

    Ip, Hing-Lung; Chan, Anne Yin-Yan; Ng, Kit-Chung; Soo, Yannie Oi-Yan; Wong, Lawrence Ka-Sing

    2013-11-01

    Factor VII deficiency is an uncommon coagulation disorder that patient usually presents with bleeding diathesis, but thrombotic event has been reported. We report a case of unusual clinical presentation in a patient with undiagnosed factor VII deficiency who presented with acute ischemic stroke. Copyright © 2013 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  4. 78 FR 53179 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    ... Proposed Rule Change To Amend Chapter VII, Section 6 of the Rules of the NASDAQ Options Market To Permit... to amend Chapter VII, Section 6 (Market Maker Quotations) of the rules of the NASDAQ Options Market... purpose of this proposed rule change is to amend Chapter VII, Section 6 of the rules of NOM to permit the...

  5. 26 CFR 20.2055-2T - Transfers not exclusively for charitable purposes (temporary).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...)(iii) The rule in paragraphs (e)(2)(vi)(a) and (e)(2)(vii)(a) of this section that guaranteed annuity... application of this rule in paragraphs (e)(2)(vi)(a) and (e)(2)(vii)(a) of this section are provided in the...) and (vii)(a) of this section, and the interest does not qualify for this transitional relief, the...

  6. A STUDY OF THE CONCURRENT VALIDITY OF THE MINNESOTA TESTS OF CREATIVE THINKING, ABBR. FORM VII, FOR EIGHTH GRADE INDUSTRIAL ARTS STUDENTS.

    ERIC Educational Resources Information Center

    DUENK, LESTER G.

    THE PRIMARY OBJECTIVE OF THIS STUDY WAS TO ESTABLISH THE CONCURRENT VALIDITY OF THE MINNESOTA TESTS OF CREATIVE THINKING, ABBREVIATED FORM VII, (MTCT VII) BY DETERMINING THE RELATIONSHIP BETWEEN ITS SCORES AND CREATIVE ABILITY AS MEASURED BY ACCUMULATED TEACHER RATINGS OF INDUSTRIAL ARTS PROJECTS AND INVESTIGATOR-DEVELOPED TESTS OF CREATIVITY. THE…

  7. Western Shallow Oil Zone, Elk Hills Field, Kern County, California:

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Carey, K.B.

    1987-09-01

    The general Reservoir Study of the Western Shallow Oil Zone was prepared by Evans, Carey and Crozier as Task Assignment 009 with the United States Department of Energy. This study, Appendix II addresses the first Wilhelm Sands and its sub unites and pools. Basic pressure, production and assorted technical data were provided by the US Department of Energy staff at Elk Hills. These data were accepted as furnished with no attempt being made by Evans, Carey and Crozier for independent verification. This study has identified the petrophysical properties and the past productive performance of the reservoir. Primary reserves have beenmore » determined and general means of enhancing future recovery have been suggested. It is hoped that this volume can now additionally serve as a take off point for exploitation engineers to develop specific programs toward the end.« less

  8. Factor VII Deficiency: Clinical Phenotype, Genotype and Therapy.

    PubMed

    Napolitano, Mariasanta; Siragusa, Sergio; Mariani, Guglielmo

    2017-03-28

    Factor VII deficiency is the most common among rare inherited autosomal recessive bleeding disorders, and is a chameleon disease due to the lack of a direct correlation between plasma levels of coagulation Factor VII and bleeding manifestations. Clinical phenotypes range from asymptomatic condition-even in homozygous subjects-to severe life-threatening bleedings (central nervous system, gastrointestinal bleeding). Prediction of bleeding risk is thus based on multiple parameters that challenge disease management. Spontaneous or surgical bleedings require accurate treatment schedules, and patients at high risk of severe hemorrhages may need prophylaxis from childhood onwards. The aim of the current review is to depict an updated summary of clinical phenotype, laboratory diagnosis, and treatment of inherited Factor VII deficiency.

  9. Factor VII Deficiency: Clinical Phenotype, Genotype and Therapy

    PubMed Central

    Napolitano, Mariasanta; Siragusa, Sergio; Mariani, Guglielmo

    2017-01-01

    Factor VII deficiency is the most common among rare inherited autosomal recessive bleeding disorders, and is a chameleon disease due to the lack of a direct correlation between plasma levels of coagulation Factor VII and bleeding manifestations. Clinical phenotypes range from asymptomatic condition—even in homozygous subjects—to severe life-threatening bleedings (central nervous system, gastrointestinal bleeding). Prediction of bleeding risk is thus based on multiple parameters that challenge disease management. Spontaneous or surgical bleedings require accurate treatment schedules, and patients at high risk of severe hemorrhages may need prophylaxis from childhood onwards. The aim of the current review is to depict an updated summary of clinical phenotype, laboratory diagnosis, and treatment of inherited Factor VII deficiency. PMID:28350321

  10. Patient Experience and Views on Antiretroviral Treatment—Findings from the Positive Perspectives Survey

    PubMed Central

    Young, Benjamin; Spire, Bruno; Morcillo, Diego Garcia; Muchenje, 
Marvelous; Parkinson, Kneeshe; Krehl, Moritz; Marcotullio, Simone; Allan, Brent; Punekar, Yogesh; Namiba, Angelina; deRuiter, Annemiek; Barthel, Sophie; Koteff, Justin; Garris, Cindy; Nguyen, Christopher; Ustianowski, Andrew; Ferrer, Pedro Eitz; Murungi, Andrew

    2017-01-01

    Abstract Background While advances in treatment have dramatically improved the life-expectancy of people living with HIV (PLHIV), a number of unmet needs remain. We conducted an international survey of PLHIV to explore their level of satisfaction with current treatment and potential areas of improvement for ARVs. Methods Qualitative in-depth interviews were performed with PLHIV to identify key hypotheses. A steering group developed the survey questions which was fielded online from November 2016 to April 2017 in 9 countries across North America, Europe and Australia. A mixed sampling/recruitment approach was used to ensure a broad cross-section of PLHIV. Respondents were screened for eligibility prior to receiving access to the online survey Results Overall 1085 PLHIV completed the survey with 40% of respondents from North America. The demographic breakdown was 25% women, 34% >50 years, 49% diagnosed >10 years ago, 76 % with co-morbidities. 40% had a college degree or higher, 33% were in full-time employment and 62% lived in a large city. Majority (98%) were currently taking ARVs with 53% taking a Single Tablet Regimen (STR). 87% of those diagnosed within last 2 years had started treatment within 6 months of diagnosis, compared with 40% of those diagnosed > 10 years ago. Of those on treatment, 87% were satisfied with their current ARV regimen. 33% had changed treatment in the last 12 months with the main reasons for switching being reducing severity or frequency of side effects (43%) and reducing the pill burden (31%). 73% of those on treatment were worried about the long-term effects of ARVs. Reducing these long-term effects (25%) and the potential availability of longer lasting treatments (21%) were identified as the 2 most important potential improvements to current regimens. 62% were open to changing to an ARV regimen with fewer drugs as long as their HIV remained suppressed. Demographics and results for the North American cohort were generally similar to the overall global results. Conclusion In this international survey, the majority of PLHIV were satisfied with their current regimen, with reducing long-term adverse effects of ARVs and a longer lasting treatment identified as the most important potential improvements. Disclosures B. Young, ViiV Healthcare: Consultant and Scientific Advisor, Consulting fee and Research support; Gilead: Consultant and Scientific Advisor, Consulting fee and Research support; Merck: Consultant, Scientific Advisor and Speaker’s Bureau, Consulting fee and Research support; B. Spire, Gilead: Scientific Advisor, Consulting fee; MSD: Scientific Advisor, Consulting fee; D. Garcia Morcillo, ViiV Healthcare: Consultant, Consulting fee; K. Parkinson, ViiV Healthcare: Consultant, Consulting fee; M. Krehl, ViiV Healthcare: Consultant, Consulting fee; S. Marcotullio, Abbvie, Gilead sciences, Janssen-Cilag: Scientific Advisor, Consulting fee and Research grant; B. Allan, ViiV Healthcare: Consultant, Consulting fee; Y. Punekar, ViiV Healthcare: Employee and Shareholder, Salary; A. deRuiter, ViiV Healthcare: Employee and Shareholder, Salary; S. Barthel, GlaxoSmithKline: Employee and Shareholder, Salary; J. Koteff, ViiV Healthcare: Employee and Shareholder, Salary; C. Garris, ViiV Healthcare: Employee and Shareholder, Salary; C. Nguyen, ViiV Healthcare: Employee and Shareholder, Salary; A. Ustianowski, ViiV: Speaker’s Bureau, Conference sponsorship; Gilead: Grant Investigator, Scientific Advisor and Speaker’s Bureau, Consulting fee, Grant recipient and Speaker honorarium; MSD: Scientific Advisor and Speaker’s Bureau, Consulting fee and Speaker honorarium; Janssen: Scientific Advisor, Consulting fee; Abbvie: Grant Investigator, Grant recipient; P. Eitz Ferrer, ViiV Healthcare: Employee and Shareholder, Salary; A. Murungi, ViiV Healthcare: Employee, Salary

  11. The Economics of Enforcement of Title VII of the Civil Rights Act of 1964. Discussion Papers No. 313-75.

    ERIC Educational Resources Information Center

    Beller, Andrea H.

    The purpose of this paper is to estimate the effects of enforcement of Title VII to determine whether and to what extent it has helped to achieve the elimination of employment discrimination. The model developed in this paper is considered to depart from those of previous Title VII studies in two ways. First, it incorporates the effects of the…

  12. Title VII funding is associated with more family physicians and more physicians serving the underserved.

    PubMed

    Meyers, D; Fryer, G E; Krol, D; Phillips, R L; Green, L A; Dovey, S M

    2002-08-15

    Title VII funding of departments of family medicine at U.S. medical schools is significantly associated with expansion of the primary care physician workforce and increased accessibility to physicians for the residents of rural and underserved areas. Title VII has been successful in achieving its stated goals and has had an important role in addressing U.S. physician workforce policy issues.

  13. Tissue factor is an angiogenic-specific receptor for factor VII-targeted immunotherapy and photodynamic therapy.

    PubMed

    Hu, Zhiwei; Cheng, Jijun; Xu, Jie; Ruf, Wolfram; Lockwood, Charles J

    2017-02-01

    Identification of target molecules specific for angiogenic vascular endothelial cells (VEC), the inner layer of pathological neovasculature, is critical for discovery and development of neovascular-targeting therapy for angiogenesis-dependent human diseases, notably cancer, macular degeneration and endometriosis, in which vascular endothelial growth factor (VEGF) plays a central pathophysiological role. Using VEGF-stimulated vascular endothelial cells (VECs) isolated from microvessels, venous and arterial blood vessels as in vitro angiogenic models and unstimulated VECs as a quiescent VEC model, we examined the expression of tissue factor (TF), a membrane-bound receptor on the angiogenic VEC models compared with quiescent VEC controls. We found that TF is specifically expressed on angiogenic VECs in a time-dependent manner in microvessels, venous and arterial vessels. TF-targeted therapeutic agents, including factor VII (fVII)-IgG1 Fc and fVII-conjugated photosensitizer, can selectively bind angiogenic VECs, but not the quiescent VECs. Moreover, fVII-targeted photodynamic therapy can selectively and completely eradicate angiogenic VECs. We conclude that TF is an angiogenic-specific receptor and the target molecule for fVII-targeted therapeutics. This study supports clinical trials of TF-targeted therapeutics for the treatment of angiogenesis-dependent diseases such as cancer, macular degeneration and endometriosis.

  14. Topical application of recombinant activated factor VII during cesarean delivery for placenta previa.

    PubMed

    Schjoldager, Birgit T B G; Mikkelsen, Emmeli; Lykke, Malene R; Præst, Jørgen; Hvas, Anne-Mette; Heslet, Lars; Secher, Niels J; Salvig, Jannie D; Uldbjerg, Niels

    2017-06-01

    During cesarean delivery in patients with placenta previa, hemorrhaging after removal of the placenta is often challenging. In this condition, the extraordinarily high concentration of tissue factor at the placenta site may constitute a principle of treatment as it activates coagulation very effectively. The presumption, however, is that tissue factor is bound to activated factor VII. We hypothesized that topical application of recombinant activated factor VII at the placenta site reduces bleeding without affecting intravascular coagulation. We included 5 cases with planned cesarean delivery for placenta previa. After removal of the placenta, the surgeon applied a swab soaked in recombinant activated factor VII containing saline (1 mg in 246 mL) to the placenta site for 2 minutes; this treatment was repeated once if the bleeding did not decrease sufficiently. We documented the treatment on video recordings and measured blood loss. Furthermore, we determined hemoglobin concentration, platelet count, international normalized ratio, activated partial thrombin time, fibrinogen (functional), factor VII:clot, and thrombin generation in peripheral blood prior to and 15 minutes after removal of the placenta. We also tested these blood coagulation variables in 5 women with cesarean delivery planned for other reasons. Mann-Whitney test was used for unpaired data. In all 5 cases, the uterotomy was closed under practically dry conditions and the median blood loss was 490 (range 300-800) mL. There were no adverse effects of recombinant activated factor VII and we did not measure factor VII to enter the circulation. Neither did we observe changes in thrombin generation, fibrinogen, activated partial thrombin time, international normalized ratio, and platelet count in the peripheral circulation (all P values >.20). This study indicates that in patients with placenta previa, topical recombinant activated factor VII may diminish bleeding from the placenta site without initiation of systemic coagulation. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  15. United States Air Force F-35A Operational Basing Environmental Impact Statement. Appendix E: Comments

    DTIC Science & Technology

    2013-09-01

    this pork -laden boondoggle down our throats? Finally, to those who accuse F-35 opponents of being unpatriotic, you should know better. Patriotism is...Vermont Air Guard base as the members bring money into the ar ea during training weekends/days for food , housing and entertainment. These monies...adults and children living in the noise zone 3. There was no crash data for FY 13 fo r the F-22 (page BR4-49/50) ’] • Since safety estimates of the F-35A

  16. Prolonged Prothrombin Time After Recombinant Activated Factor VII Therapy in Critically Bleeding Trauma Patients Is Associated With Adverse Outcomes

    DTIC Science & Technology

    2010-07-01

    using the FVII coagulant activity (FVII:C) assay, a one- stage assay using thromboplastin tissue factor , which quantifies FVII clotting activity in...and the resultant production of dysfunctional factors II, VII, and X. This study focused on PT specifically because this measure examines the TF...ORIGINAL ARTICLE Prolonged Prothrombin Time After Recombinant Activated Factor VII Therapy in Critically Bleeding Trauma Patients Is Associated With

  17. 29 CFR 1620.27 - Relationship to the Equal Pay Act of title VII of the Civil Rights Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Relationship to the Equal Pay Act of title VII of the Civil... OPPORTUNITY COMMISSION THE EQUAL PAY ACT § 1620.27 Relationship to the Equal Pay Act of title VII of the Civil... equal pay under the Equal Pay Act has no relationship to whether the employee is in the lower paying job...

  18. Rhenium(VII) Catalysis of Prins Cyclization Reactions

    PubMed Central

    Tadpetch, Kwanruthai; Rychnovsky, Scott D.

    2009-01-01

    The rhenium(VII) complex O3ReOSiPh3 are particularly effective catalyst for Prins cyclizations using aromatic and α,β-unsaturated aldehydes. The reaction conditions are mild and the highly substituted 4-hydroxy tetrahydropyran products are formed stereoselectively. Rhenium(VII) complexes appear to spontaneously form esters with alcohols and to directly activate electron rich alcohols for solvolysis. Re2O7 and perrhenic acid were equally effective in catalyzing these cyclizations. PMID:18816133

  19. Plasmodium falciparum ookinete expression of plasmepsin VII and plasmepsin X.

    PubMed

    Li, Fengwu; Bounkeua, Viengngeun; Pettersen, Kenneth; Vinetz, Joseph M

    2016-02-24

    Plasmodium invasion of the mosquito midgut is a population bottleneck in the parasite lifecycle. Interference with molecular mechanisms by which the ookinete invades the mosquito midgut is one potential approach to developing malaria transmission-blocking strategies. Plasmodium aspartic proteases are one such class of potential targets: plasmepsin IV (known to be present in the asexual stage food vacuole) was previously shown to be involved in Plasmodium gallinaceum infection of the mosquito midgut, and plasmepsins VII and plasmepsin X (not known to be present in the asexual stage food vacuole) are upregulated in Plasmodium falciparum mosquito stages. These (and other) parasite-derived enzymes that play essential roles during ookinete midgut invasion are prime candidates for transmission-blocking vaccines. Reverse transcriptase PCR (RT-PCR) was used to determine timing of P. falciparum plasmepsin VII (PfPM VII) and plasmepsin X (PfPM X) mRNA transcripts in parasite mosquito midgut stages. Protein expression was confirmed by western immunoblot and immunofluorescence assays (IFA) using anti-peptide monoclonal antibodies (mAbs) against immunogenic regions of PfPM VII and PfPM X. These antibodies were also used in standard membrane feeding assays (SMFA) to determine whether inhibition of these proteases would affect parasite transmission to mosquitoes. The Mann-Whitney U test was used to analyse mosquito transmission assay results. RT-PCR, western immunoblot and immunofluorescence assay confirmed expression of PfPM VII and PfPM X in mosquito stages. Whereas PfPM VII was expressed in zygotes and ookinetes, PfPM X was expressed in gametes, zygotes, and ookinetes. Antibodies against PfPM VII and PfPM X decreased P. falciparum invasion of the mosquito midgut when used at high concentrations, indicating that these proteases play a role in Plasmodium mosquito midgut invasion. Failure to generate genetic knockouts of these genes limited determination of the precise role of these proteases in parasite transmission but suggests that they are essential during the intraerythrocytic life cycle. PfPM VII and PfPM X are present in the mosquito-infective stages of P. falciparum. Standard membrane feeding assays demonstrate that antibodies against these proteins reduce the infectivity of P. falciparum for mosquitoes, suggesting their viability as transmission-blocking vaccine candidates. Further study of the role of these plasmepsins in P. falciparum biology is warranted.

  20. A role for very low-dose recombinant activated factor VII in refractory bleeding after cardiac surgery: Lessons from an observational study.

    PubMed

    Hoffmann, Till; Assmann, Alexander; Dierksen, Angelika; Roussel, Elisabeth; Ullrich, Sebastian; Lichtenberg, Artur; Albert, Alexander; Sixt, Stephan

    2018-04-18

    Although off-label use of recombinant activated factor VII against refractory bleeding is incorporated in current guideline recommendations, safety concerns persist predominantly with respect to thromboembolic complications. We analyzed the safety and efficacy of recombinant activated factor VII at a very low dose in cardiosurgical patients with refractory bleeding. This prospective study includes 1180 cardiosurgical patients at risk of bleeding. Goal-directed substitution was based on real-time laboratory testing and clinical scoring of the bleeding intensity. All patients who fulfilled the criteria for enhanced risk of bleeding (n = 281) were consequently included in the present analysis. Patients in whom refractory bleeding developed despite substitution with specific hemostatic compounds (n = 167) received a single shot of very low-dose recombinant activated factor VII (≤20 μg/kg). Mortality and risk of thromboembolic complications, and freedom from stroke and acute myocardial infarction in particular, were analyzed (vs patients without recombinant activated factor VII) by multivariable logistic and Cox regression analyses, as well as Kaplan-Meier estimates. There was no increase in rates of mortality (30-day mortality 4.2% vs 7.0% with P = .418; follow-up survival 85.6% at 13.0 [interquartile range, 8.4-15.7] months vs 80.7% at 10.2 [interquartile range, 7.2-16.1] months with P = .151), thromboembolic complications (6.6% vs 9.6% with P = .637), renal insufficiency, need for percutaneous coronary intervention, duration of ventilation, duration of hospital stay, or rehospitalization in patients receiving very low-dose recombinant activated factor VII compared with patients not receiving recombinant activated factor VII. Complete hemostasis without any need for further hemostatic treatment was achieved after very low-dose recombinant activated factor VII administration in the majority of patients (up to 88.6% vs 0% with P < .001). The key results were confirmed after adjustment by propensity score-based analyses. When combined with early and specific restoration of hemostatic reserves after cardiac surgery, very low-dose recombinant activated factor VII treatment of refractory bleeding is effective and not associated with any apparent increase in adverse events. Copyright © 2018 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

  1. Title VII funding and physician practice in rural or low-income areas.

    PubMed

    Krist, Alex H; Johnson, Robert E; Callahan, David; Woolf, Steven H; Marsland, David

    2005-01-01

    Whether Title VII funding enhances physician supply in underserved areas has not clearly been established. To determine the relation between Title VII funding in medical school, residency, or both, and the number of family physicians practicing in rural or low-income communities. A retrospective cross sectional analysis was carried out using the 2000 American Academy of Family Physicians physician database, Title VII funding records, and 1990 U.S. Census data. Included were 9,107 family physicians practicing in 9 nationally representative states in the year 2000. Physicians exposed to Title VII funding through medical school and residency were more likely to have their current practice in low-income communities (11.9% vs 9.9%, P< or =.02) and rural areas (24.5% vs 21.8%, P< or =.02). Physicians were more likely to practice in rural communities if they attended medical schools (24.2% vs 21.4%; P =.009) and residencies (24.0% vs 20.3%; P =.011) after the school or program had at least 5 years of Title VII funding vs before. Similar increases were not observed for practice in low-income communities. In a multivariate analysis, exposure to funding and attending an institution with more years of funding independently increased the odds of practicing in rural or low-income communities. Title VII funding is associated with an increase in the family physician workforce in rural and low-income communities. This effect is temporally related to initiation of funding and independently associated with effect in a multivariate analysis, suggesting a potential causal relationship. Whereas the absolute 2% increase in family physicians in these underserved communities may seem modest, it can represent a substantial increase in access to health care for community members.

  2. In vitro effects of recombinant activated factor VII on thrombin generation and coagulation following inhibition of platelet procoagulant activity by prasugrel.

    PubMed

    Mazzeffi, Michael; Szlam, Fania; Jakubowski, Joseph A; Tanaka, Kenichi A; Sugidachi, Atsuhiro; Levy, Jerrold H

    2013-07-01

    Prasugrel is a thienopyridyl P2Y12 antagonist with potent antiplatelet effects. At present, little is known about its effects on thrombin generation or what strategies may emergently reverse its anticoagulant effects. In the current study we evaluated whether recombinant activated factor VII may reverse prasugrel induced effects and increase thrombin generation in an in vitro model. The effect of prasugrel active metabolite, PAM (R-138727), was evaluated on platelet aggregation, thrombin generation, and rotational thromboelastometry parameters using blood from 20 healthy volunteers. Additionally, we evaluated the effects of adenosine diphosphate (ADP) and recombinant activated factor VII on restoring these parameters towards baseline values. PAM reduced maximum platelet aggregation and led to platelet disaggregation. It also decreased peak thrombin, increased lag time, and increased time to peak thrombin. Treatment with recombinant activated factor VII restored all three parameters of thrombin generation towards baseline. ADP decreased lag time and time to peak thrombin, but had no effect on peak thrombin. When recombinant activated factor VII and ADP were combined they had a greater effect on thrombin parameters than either drug alone. PAM also increased thromboelastometric clotting time and clot formation time, but had no effect on maximum clot firmness. Treatment with either recombinant activated factor VII or ADP restored these values towards baseline. Recombinant activated factor VII restores thrombin generation in the presence of PAM. In patients taking prasugrel with life-threatening refractory bleeding it has the potential to be a useful therapeutic approach. Additional clinical studies are needed to validate our findings. Copyright © 2013 Elsevier Ltd. All rights reserved.

  3. Coagulation factor VII is regulated by androgen receptor in breast cancer.

    PubMed

    Naderi, Ali

    2015-02-01

    Androgen receptor (AR) is widely expressed in breast cancer; however, there is limited information on the key molecular functions and gene targets of AR in this disease. In this study, gene expression data from a cohort of 52 breast cancer cell lines was analyzed to identify a network of AR co-expressed genes. A total of 300 genes, which were significantly enriched for cell cycle and metabolic functions, showed absolute correlation coefficients (|CC|) of more than 0.5 with AR expression across the dataset. In this network, a subset of 35 "AR-signature" genes were highly co-expressed with AR (|CC|>0.6) that included transcriptional regulators PATZ1, NFATC4, and SPDEF. Furthermore, gene encoding coagulation factor VII (F7) demonstrated the closest expression pattern with AR (CC=0.716) in the dataset and factor VII protein expression was significantly associated to that of AR in a cohort of 209 breast tumors. Moreover, functional studies demonstrated that AR activation results in the induction of factor VII expression at both transcript and protein levels and AR directly binds to a proximal region of F7 promoter in breast cancer cells. Importantly, AR activation in breast cancer cells induced endogenous factor VII activity to convert factor X to Xa in conjunction with tissue factor. In summary, F7 is a novel AR target gene and AR activation regulates the ectopic expression and activity of factor VII in breast cancer cells. These findings have functional implications in the pathobiology of thromboembolic events and regulation of factor VII/tissue factor signaling in breast cancer. Copyright © 2014 Elsevier Inc. All rights reserved.

  4. Understanding the role of manganese dioxide in the oxidation of phenolic compounds by aqueous permanganate.

    PubMed

    Jiang, Jin; Gao, Yuan; Pang, Su-Yan; Lu, Xue-Ting; Zhou, Yang; Ma, Jun; Wang, Qiang

    2015-01-06

    Recent studies have shown that manganese dioxide (MnO2) can significantly accelerate the oxidation kinetics of phenolic compounds such as triclosan and chlorophenols by potassium permanganate (Mn(VII)) in slightly acidic solutions. However, the role of MnO2 (i.e., as an oxidant vs catalyst) is still unclear. In this work, it was demonstrated that Mn(VII) oxidized triclosan (i.e., trichloro-2-phenoxyphenol) and its analogue 2-phenoxyphenol, mainly generating ether bond cleavage products (i.e., 2,4-dichlorophenol and phenol, respectively), while MnO2 reacted with them producing appreciable dimers as well as hydroxylated and quinone-like products. Using these two phenoxyphenols as mechanistic probes, it was interestingly found that MnO2 formed in situ or prepared ex situ greatly accelerated the kinetics but negligibly affected the pathways of their oxidation by Mn(VII) at acidic pH 5. The yields (R) of indicative products 2,4-dichlorophenol and phenol from their respective probes (i.e., molar ratios of product formed to probe lost) under various experimental conditions were quantified. Comparable R values were obtained during the treatment by Mn(VII) in the absence vs presence of MnO2. Meanwhile, it was confirmed that MnO2 could accelerate the kinetics of Mn(VII) oxidation of refractory nitrophenols (i.e., 2-nitrophenol and 4-nitrophenol), which otherwise showed negligible reactivity toward Mn(VII) and MnO2 individually, and the effect of MnO2 was strongly dependent upon its concentration as well as solution pH. These results clearly rule out the role of MnO2 as a mild co-oxidant and suggest a potential catalytic effect on Mn(VII) oxidation of phenolic compounds regardless of their susceptibility to oxidation by MnO2.

  5. Compression Freezing Kinetics of Water to Ice VII

    DOE PAGES

    Gleason, A. E.; Bolme, C. A.; Galtier, E.; ...

    2017-07-11

    Time-resolved x-ray diffraction (XRD) of compressed liquid water shows transformation to ice VII in 6 nsec, revealing crystallization rather than amorphous solidification during compression freezing. Application of classical nucleation theory indicates heterogeneous nucleation and one-dimensional (e.g., needlelike) growth. In conclusion, these first XRD data demonstrate rapid growth kinetics of ice VII with implications for fundamental physics of diffusion-mediated crystallization and thermodynamic modeling of collision or impact events on ice-rich planetary bodies.

  6. Compression Freezing Kinetics of Water to Ice VII

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gleason, A. E.; Bolme, C. A.; Galtier, E.

    Time-resolved x-ray diffraction (XRD) of compressed liquid water shows transformation to ice VII in 6 nsec, revealing crystallization rather than amorphous solidification during compression freezing. Application of classical nucleation theory indicates heterogeneous nucleation and one-dimensional (e.g., needlelike) growth. In conclusion, these first XRD data demonstrate rapid growth kinetics of ice VII with implications for fundamental physics of diffusion-mediated crystallization and thermodynamic modeling of collision or impact events on ice-rich planetary bodies.

  7. Specific DNA binding of a potential transcriptional regulator, inosine 5'-monophosphate dehydrogenase-related protein VII, to the promoter region of a methyl coenzyme m reductase I-encoding operon retrieved from Methanothermobacter thermautotrophicus strain DeltaH.

    PubMed

    Shinzato, Naoya; Enoki, Miho; Sato, Hiroaki; Nakamura, Kohei; Matsui, Toru; Kamagata, Yoichi

    2008-10-01

    Two methyl coenzyme M reductases (MCRs) encoded by the mcr and mrt operons of the hydrogenotrophic methanogen Methanothermobacter thermautotrophicus DeltaH are expressed in response to H(2) availability. In the present study, cis elements and trans-acting factors responsible for the gene expression of MCRs were investigated by using electrophoretic mobility shift assay (EMSA) and affinity particle purification. A survey of their operator regions by EMSA with protein extracts from mrt-expressing cultures restricted them to 46- and 41-bp-long mcr and mrt upstream regions, respectively. Affinity particle purification of DNA-binding proteins conjugated with putative operator regions resulted in the retrieval of a protein attributed to IMP dehydrogenase-related protein VII (IMPDH VII). IMPDH VII is predicted to have a winged helix-turn-helix DNA-binding motif and two cystathionine beta-synthase domains, and it has been suspected to be an energy-sensing module. EMSA with oligonucleotide probes with unusual sequences showed that the binding site of IMPDH VII mostly overlaps the factor B-responsible element-TATA box of the mcr operon. The results presented here suggest that IMPDH VII encoded by MTH126 is a plausible candidate for the transcriptional regulator of the mcr operon in this methanogen.

  8. Energy Savings of Low-E Storm Windows and Panels across US Climate Zones

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Culp, Thomas D.; Cort, Katherine A.

    This report builds off of previous modeling work related to low-e storm windows used to create a "Database of U.S. Climate-Based Analysis for Low-E Storm Windows." This work updates similar studies using new fuel costs and examining the separate contributions of reduced air leakage and reduced coefficients of overall heat transfer and solar heat gain. In this report we examine the energy savings and cost effectiveness of low-E storm windows in residential homes across a broad range of U.S. climates, excluding the impact from infiltration reductions, which tend to vary using the National Energy Audit Tool (NEAT) and RESFEN modelmore » calculations. This report includes a summary of the results, NEAT and RESFEN background, methodology, and input assumptions, and an appendix with detailed results and assumptions by climate zone.« less

  9. Prophylactic treatment of hereditary severe factor VII deficiency in pregnancy.

    PubMed

    Pfrepper, Christian; Siegemund, Annelie; Hildebrandt, Sven; Kronberg, Juliane; Scholz, Ute; Niederwieser, Dietger

    2017-09-01

    : Severe hereditary factor VII deficiency is a rare bleeding disorder and may be associated with a severe bleeding phenotype. We describe a pregnancy in a 33-year-old woman with compound heterozygous factor VII deficiency and a history of severe menorrhagia and mucocutaneous bleedings. After discontinuation of contraceptives, menstruation was covered with recombinant activated factor VII (rFVIIa), and during pregnancy, rFVIIa had to be administered in first trimester in doses ranging from 15 to 90 μg/kg per day because of recurrent retroplacental hematomas and vaginal bleedings. Thrombin generation was measured in first trimester at different doses of rFVIIa and showed an increase in lag time when doses of less than 30 μg/kg/day were administered, whereas time to thrombin peak and peak thrombin were not influenced. A low-dose rFVIIa prophylactic treatment of 15 μg/kg every other day in the late second and in the third trimester was sufficient to allow a successful childbirth in this patient with severe factor VII deficiency.

  10. Antibacterial and DNA cleavage activity of carbonyl functionalized N-heterocyclic carbene-silver(I) and selenium compounds

    NASA Astrophysics Data System (ADS)

    Haque, Rosenani A.; Iqbal, Muhammad Adnan; Mohamad, Faisal; Razali, Mohd R.

    2018-03-01

    The article describes syntheses and characterizations of carbonyl functionalized benzimidazolium salts, I-IV. While salts I-III are unstable at room temperature, salt IV remained stable and was further utilised to form N-heterocyclic carbene (NHC) compounds of silver(I), V and VI, and selenium compound, VII respectively. Compounds IV-VII were tested for their antibacterial potential against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Salt IV shows a very low inhibition potential (minimum inhibitory concentration, MIC 500 μg/mL) compared to the respective silver(I)-NHC, V and VI (MIC 31.25 μg/mL against both, E. coli and S. aureus) and selenium compound, VII (MIC 125 μg/mL against E. coli and 62.50 μg/mL against S. aureus). In DNA cleavage abilities, all the test compounds cleave DNA in which the VII cleaves the DNA at the faster rate. Meanwhile, the silver(I)-NHC complexes V and VI act at the same mode and pattern of DNA cleavage while VII is similar to IV.

  11. New isochromophilones VII and VIII produced by Penicillium sp. FO-4164.

    PubMed

    Yang, D J; Tomoda, H; Tabata, N; Masuma, R; Omura, S

    1996-03-01

    New isochromophilones VII and VIII were isolated from the culture broth of Penicillium sp. FO-4164. The structures were elucidated as 6H-2-benzopyran-6,8(7H)-dione, 5-chloro-3-(3',5'-dimethyl-1',3'-heptadienyl)-1,7,8a-trihydro-7, 8a-dihydroxy-7-methyl-7-acetate for isochromophilone VII and 6H-2-benzopyran-6-one,5-chloro-3-(3',5'-dimethyl-1', 3'-heptadienyl)-1,7,8,8a-tetrahydro-7,8-dihydroxy-7-methyl-8-acetate for isochromophilone VIII. Isochromophilones VII and VIII inhibited diacylglycerol acyltransferase activity with IC50 values of 20.0 and 127 microM and acyl-CoA: cholesterol acyltransferase activity with IC50 values of 24.5 and 47.0 microM, respectively.

  12. Serendipitous Discovery of Factor VII Deficiency and the Ensuing Dilemma.

    PubMed

    Umakanthan, Jayadev M; Dhakal, Prajwal; Gundabolu, Krishna; Koepsell, Scott A; Baljevic, Muhamed

    2018-03-01

    Congenital factor VII deficiency is a challenging disorder to manage, as it is associated with varied genotypes that do not clinically correlate with a bleeding phenotype. Individuals with severe factor VII deficiency (FVII: c <1%) might be asymptomatic, while patients with moderate deficiency (FVII: c level >5%) may experience severe hemorrhages. In modern medicine, due to extensive routine pre-operative laboratory testing, clinically asymptomatic patients without any bleeding history might be incidentally discovered, raising clinical dilemmas. Careful consideration of bleeding versus thrombosis risk has to be made in such cases, especially in the elderly. Clinical history of no prior bleeding complications may be a reassuring factor. Minimal required replacement dosing of recombinant activated factor VII can be given peri-operatively in such situations, with close monitoring.

  13. Emission line spectra of S VII ? S XIV in the 20 ? 75 ? wavelength region

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lepson, J K; Beiersdorfer, P; Behar, E

    As part of a larger project to complete a comprehensive catalogue of astrophysically relevant emission lines in support of new-generation X-ray observatories using the Lawrence Livermore electron beam ion traps EBIT-I and EBIT-II, the authors present observations of sulfur lines in the soft X-ray and extreme ultraviolet regions. The database includes wavelength measurements with standard errors, relative intensities, and line assignments for 127 transitions of S VII through S XIV between 20 and 75 {angstrom}. The experimental data are complemented with a full set of calculations using the Hebrew University Lawrence Livermore Atomic Code (HULLAC). A comparison of the laboratorymore » data with Chandra measurements of Procyon allows them to identify S VII-S XI lines.« less

  14. Reactivated faulting near Cushing, Oklahoma: Increased potential for a triggered earthquake in an area of United States strategic infrastructure

    USGS Publications Warehouse

    McNamara, Daniel E.; Hayes, Gavin; Benz, Harley M.; Williams, Robert; McMahon, Nicole D; Aster, R.C.; Holland, Austin F.; Sickbert, T; Herrmann, Robert B.; Briggs, Richard; Smoczyk, Gregory M.; Bergman, Eric; Earle, Paul S.

    2015-01-01

    In October 2014 two moderate-sized earthquakes (Mw 4.0 and 4.3) struck south of Cushing, Oklahoma, below the largest crude oil storage facility in the world. Combined analysis of the spatial distribution of earthquakes and regional moment tensor focal mechanisms indicate reactivation of a subsurface unnamed and unmapped left-lateral strike-slip fault. Coulomb failure stress change calculations using the relocated seismicity and slip distribution determined from regional moment tensors, allow for the possibility that the Wilzetta-Whitetail fault zone south of Cushing, Oklahoma, could produce a large, damaging earthquake comparable to the 2011 Prague event. Resultant very strong shaking levels (MMI VII) in the epicentral region present the possibility of this potential earthquake causing moderate to heavy damage to national strategic infrastructure and local communities.

  15. [High Resolution Remote Sensing Monitoring and Assessment of Secondary Geological Disasters Triggered by the Lushan Earthquake].

    PubMed

    Wang, Fu-tao; Wang, Shi-xin; Zhou, Yi; Wang, Li-tao; Yan, Fu-li; Li, Wen-jun; Liu, Xiong-fei

    2016-01-01

    The secondary geological disasters triggered by the Lushan earthquake on April 20, 2013, such as landslides, collapses, debris flows, etc., had caused great casualties and losses. We monitored the number and spatial distribution of the secondary geological disasters in the earthquake-hit area from airborne remote sensing images, which covered areas about 3 100 km2. The results showed that Lushan County, Baoxing County and Tianquan County were most severely affected; there were 164, 126 and 71 secondary geological disasters in these regions. Moreover, we analyzed the relationship between the distribution of the secondary geological disasters, geological structure and intensity. The results indicate that there were 4 high-hazard zones in the monitored area, one focused within six kilometers from the epicenter, and others are distributed along the two main fault zones of the Longmen Mountain. More than 97% secondary geological disasters occurred in zones with a seismic intensity of VII to IX degrees, a slope between 25 A degrees and 50 A degrees, and an altitude of between 800 and 2 000 m. At last, preliminary suggestions were proposed for the rehabilitation and reconstruction planning of Lushan earthquake. According to the analysis result, airborne and space borne remote sensing can be used accurately and effectively in almost real-time to monitor and assess secondary geological disasters, providing a scientific basis and decision making support for government emergency command and post-disaster reconstruction.

  16. The Effect of Recombinant Activated Factor VII on Mortality in Combat-Related Casualties With Severe Trauma and Massive Transfusion

    DTIC Science & Technology

    2008-02-01

    The Effect of Recombinant Activated Factor VII on Mortality in Combat-Related Casualties With Severe Trauma and Massive Transfusion Philip C...REPORT TYPE 3. DATES COVERED 00-00-2007 to 00-00-2007 4. TITLE AND SUBTITLE The Effect of Recombinant Activated Factor VII on Mortality in Combat...Boffard study,17 the effect of rFVIIa on 24-hour blood product ad- ministration was only determined for patients who lived for at least 24 hours

  17. Inhalation Toxicology. VII. Times To Incapacitation and Death for Rats Exposed Continuously to Atmospheric Acrolein Vapor

    DTIC Science & Technology

    1986-05-01

    DOT FMAM-6/5INHALATION TOXICOLOGY : Office of Aviation Medicine VII. Times to Incapacitation and Washington, D.C. 20591 D ahfrR t x oe Continuously to...Accession No. 3. Recipient’s Catalog No. pOT/FAA/AM-86/5 ,4%__ _____ 4. T,tle and Subtoie S. Report Doate INHALATION TOXICOLOGY : VII. TIMES TO...Statement " Combustion toxicology ; smoke; irritant This document is available to the public gas; time-to-incapacitation; time-to- through the National

  18. Joint Center for Lessons Learned Quarterly Bulletin. Volume 5, Issue 1, September/December 2002

    DTIC Science & Technology

    2002-09-01

    Federal Response Plan, Basic Plan, April 1999, pgs 1-2. 4 USJFCOM After-action report, XIX Winter Olympic and VII Paralympic Games , Salt Lake City Utah...the Judiciary, United States Senate, May 31, 2001. 7 USJFCOM After-action report, XIX Winter Olympic and VII Paralympic Games , Salt Lake City Utah...Learned from the XIX Winter Olympic and VII Paralympic Games , Salt Lake City Charlene (Charley) Eastman Military Analyst “Time and distance from the events

  19. The Trigeminal (V) and Facial (VII) Cranial Nerves

    PubMed Central

    Sanders, Richard D.

    2010-01-01

    There are close functional and anatomical relationships between cranial nerves V and VII in both their sensory and motor divisions. Sensation on the face is innervated by the trigeminal nerves (V) as are the muscles of mastication, but the muscles of facial expression are innervated mainly by the facial nerve (VII) as is the sensation of taste. This article briefly reviews the anatomy of these cranial nerves, disorders of these nerves that are of particular importance to psychiatry, and some considerations for differential diagnosis. PMID:20386632

  20. Genetics Home Reference: dystrophic epidermolysis bullosa

    MedlinePlus

    ... protein that is used to assemble type VII collagen. Collagens are molecules that give structure and strength to ... tendons, and ligaments, throughout the body. Type VII collagen plays an important role in strengthening and stabilizing ...

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