Automated segmentation of chronic stroke lesions using LINDA: Lesion Identification with Neighborhood Data Analysis

PubMed Central

Pustina, Dorian; Coslett, H. Branch; Turkeltaub, Peter E.; Tustison, Nicholas; Schwartz, Myrna F.; Avants, Brian

2015-01-01

The gold standard for identifying stroke lesions is manual tracing, a method that is known to be observer dependent and time consuming, thus impractical for big data studies. We propose LINDA (Lesion Identification with Neighborhood Data Analysis), an automated segmentation algorithm capable of learning the relationship between existing manual segmentations and a single T1-weighted MRI. A dataset of 60 left hemispheric chronic stroke patients is used to build the method and test it with k-fold and leave-one-out procedures. With respect to manual tracings, predicted lesion maps showed a mean dice overlap of 0.696±0.16, Hausdorff distance of 17.9±9.8mm, and average displacement of 2.54±1.38mm. The manual and predicted lesion volumes correlated at r=0.961. An additional dataset of 45 patients was utilized to test LINDA with independent data, achieving high accuracy rates and confirming its cross-institutional applicability. To investigate the cost of moving from manual tracings to automated segmentation, we performed comparative lesion-to-symptom mapping (LSM) on five behavioral scores. Predicted and manual lesions produced similar neuro-cognitive maps, albeit with some discussed discrepancies. Of note, region-wise LSM was more robust to the prediction error than voxel-wise LSM. Our results show that, while several limitations exist, our current results compete with or exceed the state-of-the-art, producing consistent predictions, very low failure rates, and transferable knowledge between labs. This work also establishes a new viewpoint on evaluating automated methods not only with segmentation accuracy but also with brain-behavior relationships. LINDA is made available online with trained models from over 100 patients. PMID:26756101

Master Mentors: Linda Golian-Lui University of Hawaii-Hilo--George Oberle George Mason University, VA

ERIC Educational Resources Information Center

Library Journal, 2005

2005-01-01

Many movers and shakers inspire admiration and even awe, but those who inspire love are the mentors who have changed lives. That is why many grateful librarians nominated Linda Golian-Lui and George Oberle. Both of them were accidental librarians, work-study students whose supervisors encouraged them to become paraprofessionals, and then…

76 FR 13271 - Gulf & Ohio Railways, Inc., H. Peter Claussen and Linda C. Claussen-Continuance in Control...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-10

... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35414] Gulf & Ohio Railways, Inc., H. Peter Claussen and Linda C. Claussen--Continuance in Control Exemption--Lancaster & Chester Railroad, LLC AGENCY: Surface Transportation Board, DOT. ACTION: Correction to notice of exemption...

STS-37 MS Linda M. Godwin during water egress exercise in JSC's WETF Bldg 29

NASA Technical Reports Server (NTRS)

1990-01-01

STS-37 Mission Specialist (MS) Linda M. Godwin, wearing launch and entry suit (LES) and launch and entry helmet (LEH), is suspended above pool via a parachute harness during water egress exercises in JSC's Weightless Environment Training Facility (WETF) Bldg 29. Godwin simulates emergency egress from a Space Shuttle. The WETF's 25-ft pool served as a simulated ocean into which a parachute landing might be made.

STS-37 MS Linda M. Godwin during water egress exercise in JSC's WETF Bldg 29

NASA Image and Video Library

1990-06-25

S90-45238 (25 June 1990) ---- Astronaut Linda M. Godwin, STS 37 mission specialist, simulates emergency egress from a Space Shuttle. The training session was held in the Johnson Space Center's (JSC) weightless environment training facility (WET-F). The 25-ft. pool in the facility served as a simulated ocean into which a parachute landing might be made. Early next year, Godwin, along with four other astronauts, will fly onboard Atlantis for a five-day mission.

Applicability of computer-aided comprehensive tool (LINDA: LINeament Detection and Analysis) and shaded digital elevation model for characterizing and interpreting morphotectonic features from lineaments

NASA Astrophysics Data System (ADS)

Masoud, Alaa; Koike, Katsuaki

2017-09-01

Detection and analysis of linear features related to surface and subsurface structures have been deemed necessary in natural resource exploration and earth surface instability assessment. Subjectivity in choosing control parameters required in conventional methods of lineament detection may cause unreliable results. To reduce this ambiguity, we developed LINDA (LINeament Detection and Analysis), an integrated tool with graphical user interface in Visual Basic. This tool automates processes of detection and analysis of linear features from grid data of topography (digital elevation model; DEM), gravity and magnetic surfaces, as well as data from remote sensing imagery. A simple interface with five display windows forms a user-friendly interactive environment. The interface facilitates grid data shading, detection and grouping of segments, lineament analyses for calculating strike and dip and estimating fault type, and interactive viewing of lineament geometry. Density maps of the center and intersection points of linear features (segments and lineaments) are also included. A systematic analysis of test DEMs and Landsat 7 ETM+ imagery datasets in the North and South Eastern Deserts of Egypt is implemented to demonstrate the capability of LINDA and correct use of its functions. Linear features from the DEM are superior to those from the imagery in terms of frequency, but both linear features agree with location and direction of V-shaped valleys and dykes and reference fault data. Through the case studies, LINDA applicability is demonstrated to highlight dominant structural trends, which can aid understanding of geodynamic frameworks in any region.

Effects of MeJA on Arabidopsis metabolome under endogenous JA deficiency

NASA Astrophysics Data System (ADS)

Cao, Jingjing; Li, Mengya; Chen, Jian; Liu, Pei; Li, Zhen

2016-11-01

Jasmonates (JAs) play important roles in plant growth, development and defense. Comprehensive metabolomics profiling of plants under JA treatment provides insights into the interaction and regulation network of plant hormones. Here we applied high resolution mass spectrometry based metabolomics approach on Arabidopsis wild type and JA synthesis deficiency mutant opr3. The effects of exogenous MeJA treatment on the metabolites of opr3 were investigated. More than 10000 ion signals were detected and more than 2000 signals showed significant variation in different genotypes and treatment groups. Multivariate statistic analyses (PCA and PLS-DA) were performed and a differential compound library containing 174 metabolites with high resolution precursor ion-product ions pairs was obtained. Classification and pathway analysis of 109 identified compounds in this library showed that glucosinolates and tryptophan metabolism, amino acids and small peptides metabolism, lipid metabolism, especially fatty acyls metabolism, were impacted by endogenous JA deficiency and exogenous MeJA treatment. These results were further verified by quantitative reverse transcription PCR (RT-qPCR) analysis of 21 related genes involved in the metabolism of glucosinolates, tryptophan and α-linolenic acid pathways. The results would greatly enhance our understanding of the biological functions of JA.

Research activities at the Loma Linda University and Proton Treatment Facility--an overview

NASA Technical Reports Server (NTRS)

Nelson, G. A.; Green, L. M.; Gridley, D. S.; Archambeau, J. O.; Slater, J. M.

2001-01-01

The Loma Linda University (LLU) Radiobiology Program coordinates basic research and proton beam service activities for the university and extramural communities. The current focus of the program is on the biological and physical properties of protons and the operation of radiobiology facilities for NASA-sponsored projects. The current accelerator, supporting facilities and operations are described along with a brief review of extramural research projects supported by the program. These include space craft electronic parts and shielding testing as well as tumorigenesis and animal behavior experiments. An overview of research projects currently underway at LLU is also described. These include: 1) acute responses of the C57Bl/6 mouse immune system, 2) modulation of gene expression in the nematode C. elegans and rat thyroid cells, 3) quantitation of dose tolerance in rat CNS microvasculature, 4) behavioral screening of whole body proton and iron ion-irradiated C57Bl/6 mice, and 5) investigation of the role of cell integration into epithelial structures on responses to radiation.

Coordinate expression of AOS genes and JA accumulation: JA is not required for initiation of closing layer in wound healing tubers

USDA-ARS?s Scientific Manuscript database

Wounding induces a series of coordinated physiological responses essential for protection and healing of the damaged tissue. Wound-induced formation of jasmonic acid (JA) is important in defense responses in leaves, but comparatively little is known about the induction of JA biosynthesis and its ro...

Synthesis, structural characterization and biological activity of two diastereomeric JA-Ile macrolactones.

PubMed

Jimenez-Aleman, Guillermo H; Machado, Ricardo A R; Görls, Helmar; Baldwin, Ian T; Boland, Wilhelm

2015-06-07

Jasmonates are phytohormones involved in a wide range of plant processes, including growth, development, senescence, and defense. Jasmonoyl-L-isoleucine (JA-Ile, 2), an amino acid conjugate of jasmonic acid (JA, 1), has been identified as a bioactive endogenous jasmonate. However, JA-Ile (2) analogues trigger different responses in the plant. ω-Hydroxylation of the pentenyl side chain leads to the inactive 12-OH-JA-Ile (3) acting as a “stop” signal. On the other hand, a lactone derivative of 12-OH-JA (5) (jasmine ketolactone, JKL) occurs in nature, although with no known biological function. Inspired by the chemical structure of JKL (6) and in order to further explore the potential biological activities of 12-modified JA-Ile derivatives, we synthesized two macrolactones (JA-Ile-lactones (4a) and (4b)) derived from 12-OH-JA-Ile (3). The biological activity of (4a) and (4b) was tested for their ability to elicit nicotine production, a well-known jasmonate dependent secondary metabolite. Both macrolactones showed strong biological activity, inducing nicotine accumulation to a similar extent as methyl jasmonate does in Nicotiana attenuata leaves. Surprisingly, the highest nicotine contents were found in plants treated with the JA-Ile-lactone (4b), which has (3S,7S) configuration at the cyclopentanone not known from natural jasmonates. Macrolactone (4a) is a valuable standard to explore for its occurrence in nature.

Endogenous Bioactive Jasmonate Is Composed of a Set of (+)-7-iso-JA-Amino Acid Conjugates1

PubMed Central

Li, Suhua; Li, Yuwen; Chen, Juan; Yang, Mai; Tong, Jianhua; Xiao, Langtao; Nan, Fajun; Xie, Daoxin

2016-01-01

Jasmonates (JAs) regulate a wide range of plant defense and development processes. The bioactive JA is perceived by its receptor COI1 to trigger the degradation of JASMONATE ZIM-DOMAIN (JAZ) proteins and subsequently derepress the JAZ-repressed transcription factors for activation of expression of JA-responsive genes. So far, (+)-7-iso-JA-l-Ile has been the only identified endogenous bioactive JA molecule. Here, we designed coronafacic acid (CFA) conjugates with all the amino acids (CFA-AA) to mimic the JA amino acid conjugates, and revealed that (+)-7-iso-JA-Leu, (+)-7-iso-JA-Val, (+)-7-iso-JA-Met, and (+)-7-iso-JA-Ala are new endogenous bioactive JA molecules. Furthermore, our studies uncover the general characteristics for all the bioactive JA molecules, and provide a new strategy to synthetically generate novel active JA molecules. PMID:27756820

Food intake diet and sperm characteristics in a blue zone: a Loma Linda Study.

PubMed

Orzylowska, Eliza M; Jacobson, John D; Bareh, Gihan M; Ko, Edmund Y; Corselli, Johannah U; Chan, Philip J

2016-08-01

The study examined the effect the life-long vegetarian diet on male fertility and focused on vegetarians living in the Loma Linda blue zone, a demographic area known for life longevity. The objective was to compare sperm characteristics of vegetarian with non-vegetarian males. The cross-sectional observational study was based on semen analyses of 474 males from 2009 to 2013. Patients categorized themselves as either life-long lacto-ovo vegetarians (N=26; vegetable diet with dairy and egg products), vegans (N=5; strictly vegetables with no animal products) or non-vegetarians (N=443; no diet restrictions). Sperm quality was assessed using a computer-aided sperm analyzer and strict morphology and chromatin integrity were manually evaluated. Lacto-ovo vegetarians had lower sperm concentration (50.7±7.4M/mL versus non-vegetarians 69.6±3.2M/mL, mean±S.E.M.). Total motility was lower in the lacto-ovo and vegan groups (33.2±3.8% and 51.8±13.4% respectively) versus non-vegetarians (58.2±1.0%). Vegans had lowest hyperactive motility (0.8±0.7% versus lacto-ovo 5.2±1.2 and non-vegetarians 4.8±0.3%). Sperm strict morphologies were similar for the 3 groups. There were no differences in rapid progression and chromatin integrity. The study showed that the vegetables-based food intake decreased sperm quality. In particular, a reduction in sperm quality in male factor patients would be clinically significant and would require review. Furthermore, inadequate sperm hyperactivation in vegans suggested compromised membrane calcium selective channels. However, the study results are cautiously interpreted and more corroborative studies are needed. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Effect of MeJA treatment on polyamine, energy status and anthracnose rot of loquat fruit.

PubMed

Cao, Shifeng; Cai, Yuting; Yang, Zhenfeng; Joyce, Daryl C; Zheng, Yonghua

2014-02-15

The effect of methyl jasmonate (MeJA) on changes in polyamines content and energy status and their relation to disease resistance was investigated. Freshly harvested loquat fruit were treated with 10 μmol l(-1) MeJA and wound inoculated with Colletotrichum acutatum spore suspension (1.0 × 10(5) spores ml(-1)) after 24h, and then stored at 20 °C for 6 days. MeJA treatment significantly reduced decay incidence. MeJA treated fruit manifested higher contents of polyamines (putrescine, spermidine and spermine) compared with the control fruit, during storage. MeJA treatment also maintained higher levels of adenosine triphosphate, and suppressed an increase in adenosine monophosphate content in loquat fruit. These results suggest that MeJA treatment may inhibit anthracnose rot by increasing polyamine content and maintaining the energy status. Copyright © 2013. Published by Elsevier Ltd.

JaSTA-2: Second version of the Java Superposition T-matrix Application

NASA Astrophysics Data System (ADS)

Halder, Prithish; Das, Himadri Sekhar

2017-12-01

In this article, we announce the development of a new version of the Java Superposition T-matrix App (JaSTA-2), to study the light scattering properties of porous aggregate particles. It has been developed using Netbeans 7.1.2, which is a java integrated development environment (IDE). The JaSTA uses double precision superposition T-matrix codes for multi-sphere clusters in random orientation, developed by Mackowski and Mischenko (1996). The new version consists of two options as part of the input parameters: (i) single wavelength and (ii) multiple wavelengths. The first option (which retains the applicability of older version of JaSTA) calculates the light scattering properties of aggregates of spheres for a single wavelength at a given instant of time whereas the second option can execute the code for a multiple numbers of wavelengths in a single run. JaSTA-2 provides convenient and quicker data analysis which can be used in diverse fields like Planetary Science, Atmospheric Physics, Nanoscience, etc. This version of the software is developed for Linux platform only, and it can be operated over all the cores of a processor using the multi-threading option.

High-Rate Mechanical Properties of JA2 Propellant at Temperatures from -50 to 80 deg C

DTIC Science & Technology

2015-07-01

panorama of postcompression JA2 grain sample (uniaxially compressed at a rate of ~100 s–1, 80 °C, and strain greater than 40%), 50× magnification...19 Fig. 36 SEM panorama of postcompression JA2 grain sample...19 Fig. 37 SEM panorama of postcompression JA2 grain sample (uniaxially compressed at a rate of ~100 s–1, 60 °C, and strain

Arabidopsis GOLDEN2-LIKE (GLK) transcription factors activate jasmonic acid (JA)-dependent disease susceptibility to the biotrophic pathogen Hyaloperonospora arabidopsidis, as well as JA-independent plant immunity against the necrotrophic pathogen Botrytis cinerea.

PubMed

Murmu, Jhadeswar; Wilton, Michael; Allard, Ghislaine; Pandeya, Radhey; Desveaux, Darrell; Singh, Jas; Subramaniam, Rajagopal

2014-02-01

Arabidopsis thaliana GOLDEN2-LIKE (GLK1 and 2) transcription factors regulate chloroplast development in a redundant manner. Overexpression of AtGLK1 (35S:AtGLK1) in Arabidopsis also confers resistance to the cereal pathogen Fusarium graminearum. To further elucidate the role of GLK transcription factors in plant defence, the Arabidopsis glk1 glk2 double-mutant and 35S:AtGLK1 plants were challenged with the virulent oomycete pathogen Hyaloperonospora arabidopsidis (Hpa) Noco2. Compared with Col-0, glk1 glk2 plants were highly resistant to Hpa Noco2, whereas 35S:AtGLK1 plants showed enhanced susceptibility to this pathogen. Genetic studies suggested that AtGLK-mediated plant defence to Hpa Noco2 was partially dependent on salicylic acid (SA) accumulation, but independent of the SA signalling protein NONEXPRESSOR OF PATHOGENESIS-RELATED 1 (NPR1). Pretreatment with jasmonic acid (JA) dramatically reversed Hpa Noco2 resistance in the glk1 glk2 double mutant, but only marginally affected the 35S:AtGLK1 plants. In addition, overexpression of AtGLK1 in the JA signalling mutant coi1-16 did not increase susceptibility to Hpa Noco2. Together, our GLK gain-of-function and loss-of-function experiments suggest that GLK acts upstream of JA signalling in disease susceptibility to Hpa Noco2. In contrast, glk1 glk2 plants were more susceptible to the necrotrophic fungal pathogen Botrytis cinerea, whereas 35S:AtGLK1 plants exhibited heightened resistance which could be maintained in the absence of JA signalling. Together, the data reveal that AtGLK1 is involved in JA-dependent susceptibility to the biotrophic pathogen Hpa Noco2 and in JA-independent resistance to the necrotrophic pathogen B. cinerea. © 2013 HER MAJESTY THE QUEEN IN RIGHT OF CANADA. MOLECULAR PLANT PATHOLOGY © 2013 BSPP. REPRODUCED WITH THE PERMISSION OF THE MINISTER OF AGRICULTURE AND AGRI-FOOD CANADA.

Parasitism by Cuscuta pentagona sequentially induces JA and SA defence pathways in tomato.

PubMed

Runyon, Justin B; Mescher, Mark C; Felton, Gary W; De Moraes, Consuelo M

2010-02-01

While plant responses to herbivores and pathogens are well characterized, responses to attack by other plants remain largely unexplored. We measured phytohormones and C(18) fatty acids in tomato attacked by the parasitic plant Cuscuta pentagona, and used transgenic and mutant plants to explore the roles of the defence-related phytohormones salicylic acid (SA) and jasmonic acid (JA). Parasite attachment to 10-day-old tomato plants elicited few biochemical changes, but a second attachment 10 d later elicited a 60-fold increase in JA, a 30-fold increase in SA and a hypersensitive-like response (HLR). Host age also influenced the response: neither Cuscuta seedlings nor established vines elicited a HLR in 10-day-old hosts, but both did in 20-day-old hosts. Parasites grew larger on hosts deficient in SA (NahG) or insensitive to JA [jasmonic acid-insensitive1 (jai1)], suggesting that both phytohormones mediate effective defences. Moreover, amounts of JA peaked 12 h before SA, indicating that defences may be coordinated via sequential induction of these hormones. Parasitism also induced increases in free linolenic and linoleic acids and abscisic acid. These findings provide the first documentation of plant hormonal signalling induced by a parasitic plant and show that tomato responses to C. pentagona display characteristics similar to both herbivore- and pathogen-induced responses.

Transcriptome Analysis in Haematococcus pluvialis: Astaxanthin Induction by Salicylic Acid (SA) and Jasmonic Acid (JA).

PubMed

Gao, Zhengquan; Li, Yan; Wu, Guanxun; Li, Guoqiang; Sun, Haifeng; Deng, Suzhen; Shen, Yicheng; Chen, Guoqiang; Zhang, Ruihao; Meng, Chunxiao; Zhang, Xiaowen

2015-01-01

Haematococcus pluvialis is an astaxanthin-rich microalga that can increase its astaxanthin production by salicylic acid (SA) or jasmonic acid (JA) induction. The genetic transcriptome details of astaxanthin biosynthesis were analyzed by exposing the algal cells to 25 mg/L of SA and JA for 1, 6 and 24 hours, plus to the control (no stress). Based on the RNA-seq analysis, 56,077 unigenes (51.7%) were identified with functions in response to the hormone stress. The top five identified subcategories were cell, cellular process, intracellular, catalytic activity and cytoplasm, which possessed 5600 (~9.99%), 5302 (~9.45%), 5242 (~9.35%), 4407 (~7.86%) and 4195 (~7.48%) unigenes, respectively. Furthermore, 59 unigenes were identified and assigned to 26 putative transcription factors (TFs), including 12 plant-specific TFs. They were likely associated with astaxanthin biosynthesis in Haematococcus upon SA and JA stress. In comparison, the up-regulation of differential expressed genes occurred much earlier, with higher transcript levels in the JA treatment (about 6 h later) than in the SA treatment (beyond 24 h). These results provide valuable information for directing metabolic engineering efforts to improve astaxanthin biosynthesis in H. pluvialis.

Transcriptome sequencing and de novo analysis of cytoplasmic male sterility and maintenance in JA-CMS cotton.

PubMed

Yang, Peng; Han, Jinfeng; Huang, Jinling

2014-01-01

Cytoplasmic male sterility (CMS) is the failure to produce functional pollen, which is inherited maternally. And it is known that anther development is modulated through complicated interactions between nuclear and mitochondrial genes in sporophytic and gametophytic tissues. However, an unbiased transcriptome sequencing analysis of CMS in cotton is currently lacking in the literature. This study compared differentially expressed (DE) genes of floral buds at the sporogenous cells stage (SS) and microsporocyte stage (MS) (the two most important stages for pollen abortion in JA-CMS) between JA-CMS and its fertile maintainer line JB cotton plants, using the Illumina HiSeq 2000 sequencing platform. A total of 709 (1.8%) DE genes including 293 up-regulated and 416 down-regulated genes were identified in JA-CMS line comparing with its maintainer line at the SS stage, and 644 (1.6%) DE genes with 263 up-regulated and 381 down-regulated genes were detected at the MS stage. By comparing the two stages in the same material, there were 8 up-regulated and 9 down-regulated DE genes in JA-CMS line and 29 up-regulated and 9 down-regulated DE genes in JB maintainer line at the MS stage. Quantitative RT-PCR was used to validate 7 randomly selected DE genes. Bioinformatics analysis revealed that genes involved in reduction-oxidation reactions and alpha-linolenic acid metabolism were down-regulated, while genes pertaining to photosynthesis and flavonoid biosynthesis were up-regulated in JA-CMS floral buds compared with their JB counterparts at the SS and/or MS stages. All these four biological processes play important roles in reactive oxygen species (ROS) homeostasis, which may be an important factor contributing to the sterile trait of JA-CMS. Further experiments are warranted to elucidate molecular mechanisms of these genes that lead to CMS.

Transcriptome Sequencing and De Novo Analysis of Cytoplasmic Male Sterility and Maintenance in JA-CMS Cotton

PubMed Central

Yang, Peng; Han, Jinfeng; Huang, Jinling

2014-01-01

Cytoplasmic male sterility (CMS) is the failure to produce functional pollen, which is inherited maternally. And it is known that anther development is modulated through complicated interactions between nuclear and mitochondrial genes in sporophytic and gametophytic tissues. However, an unbiased transcriptome sequencing analysis of CMS in cotton is currently lacking in the literature. This study compared differentially expressed (DE) genes of floral buds at the sporogenous cells stage (SS) and microsporocyte stage (MS) (the two most important stages for pollen abortion in JA-CMS) between JA-CMS and its fertile maintainer line JB cotton plants, using the Illumina HiSeq 2000 sequencing platform. A total of 709 (1.8%) DE genes including 293 up-regulated and 416 down-regulated genes were identified in JA-CMS line comparing with its maintainer line at the SS stage, and 644 (1.6%) DE genes with 263 up-regulated and 381 down-regulated genes were detected at the MS stage. By comparing the two stages in the same material, there were 8 up-regulated and 9 down-regulated DE genes in JA-CMS line and 29 up-regulated and 9 down-regulated DE genes in JB maintainer line at the MS stage. Quantitative RT-PCR was used to validate 7 randomly selected DE genes. Bioinformatics analysis revealed that genes involved in reduction-oxidation reactions and alpha-linolenic acid metabolism were down-regulated, while genes pertaining to photosynthesis and flavonoid biosynthesis were up-regulated in JA-CMS floral buds compared with their JB counterparts at the SS and/or MS stages. All these four biological processes play important roles in reactive oxygen species (ROS) homeostasis, which may be an important factor contributing to the sterile trait of JA-CMS. Further experiments are warranted to elucidate molecular mechanisms of these genes that lead to CMS. PMID:25372034

Partial Activation of SA- and JA-Defensive Pathways in Strawberry upon Colletotrichum acutatum Interaction.

PubMed

Amil-Ruiz, Francisco; Garrido-Gala, José; Gadea, José; Blanco-Portales, Rosario; Muñoz-Mérida, Antonio; Trelles, Oswaldo; de Los Santos, Berta; Arroyo, Francisco T; Aguado-Puig, Ana; Romero, Fernando; Mercado, José-Ángel; Pliego-Alfaro, Fernando; Muñoz-Blanco, Juan; Caballero, José L

2016-01-01

Understanding the nature of pathogen host interaction may help improve strawberry (Fragaria × ananassa) cultivars. Plant resistance to pathogenic agents usually operates through a complex network of defense mechanisms mediated by a diverse array of signaling molecules. In strawberry, resistance to a variety of pathogens has been reported to be mostly polygenic and quantitatively inherited, making it difficult to associate molecular markers with disease resistance genes. Colletotrichum acutatum spp. is a major strawberry pathogen, and completely resistant cultivars have not been reported. Moreover, strawberry defense network components and mechanisms remain largely unknown and poorly understood. Assessment of the strawberry response to C. acutatum included a global transcript analysis, and acidic hormones SA and JA measurements were analyzed after challenge with the pathogen. Induction of transcripts corresponding to the SA and JA signaling pathways and key genes controlling major steps within these defense pathways was detected. Accordingly, SA and JA accumulated in strawberry after infection. Contrastingly, induction of several important SA, JA, and oxidative stress-responsive defense genes, including FaPR1-1, FaLOX2, FaJAR1, FaPDF1, and FaGST1, was not detected, which suggests that specific branches in these defense pathways (those leading to FaPR1-2, FaPR2-1, FaPR2-2, FaAOS, FaPR5, and FaPR10) were activated. Our results reveal that specific aspects in SA and JA dependent signaling pathways are activated in strawberry upon interaction with C. acutatum. Certain described defense-associated transcripts related to these two known signaling pathways do not increase in abundance following infection. This finding suggests new insight into a specific putative molecular strategy for defense against this pathogen.

Partial Activation of SA- and JA-Defensive Pathways in Strawberry upon Colletotrichum acutatum Interaction

PubMed Central

Amil-Ruiz, Francisco; Garrido-Gala, José; Gadea, José; Blanco-Portales, Rosario; Muñoz-Mérida, Antonio; Trelles, Oswaldo; de los Santos, Berta; Arroyo, Francisco T.; Aguado-Puig, Ana; Romero, Fernando; Mercado, José-Ángel; Pliego-Alfaro, Fernando; Muñoz-Blanco, Juan; Caballero, José L.

2016-01-01

Understanding the nature of pathogen host interaction may help improve strawberry (Fragaria × ananassa) cultivars. Plant resistance to pathogenic agents usually operates through a complex network of defense mechanisms mediated by a diverse array of signaling molecules. In strawberry, resistance to a variety of pathogens has been reported to be mostly polygenic and quantitatively inherited, making it difficult to associate molecular markers with disease resistance genes. Colletotrichum acutatum spp. is a major strawberry pathogen, and completely resistant cultivars have not been reported. Moreover, strawberry defense network components and mechanisms remain largely unknown and poorly understood. Assessment of the strawberry response to C. acutatum included a global transcript analysis, and acidic hormones SA and JA measurements were analyzed after challenge with the pathogen. Induction of transcripts corresponding to the SA and JA signaling pathways and key genes controlling major steps within these defense pathways was detected. Accordingly, SA and JA accumulated in strawberry after infection. Contrastingly, induction of several important SA, JA, and oxidative stress-responsive defense genes, including FaPR1-1, FaLOX2, FaJAR1, FaPDF1, and FaGST1, was not detected, which suggests that specific branches in these defense pathways (those leading to FaPR1-2, FaPR2-1, FaPR2-2, FaAOS, FaPR5, and FaPR10) were activated. Our results reveal that specific aspects in SA and JA dependent signaling pathways are activated in strawberry upon interaction with C. acutatum. Certain described defense-associated transcripts related to these two known signaling pathways do not increase in abundance following infection. This finding suggests new insight into a specific putative molecular strategy for defense against this pathogen. PMID:27471515

MAPK-dependent JA and SA signalling in Nicotiana attenuata affects plant growth and fitness during competition with conspecifics

PubMed Central

2012-01-01

Background Induced defense responses to herbivores are generally believed to have evolved as cost-saving strategies that defer the fitness costs of defense metabolism until these defenses are needed. The fitness costs of jasmonate (JA)-mediated defenses have been well documented. Those of the early signaling units mediating induced resistance to herbivores have yet to be examined. Early signaling components that mediate herbivore-induced defense responses in Nicotiana attenuata, have been well characterized and here we examine their growth and fitness costs during competition with conspecifics. Two mitogen-activated protein kinases (MAPKs), salicylic acid (SA)-induced protein kinase (SIPK) and wound-induced protein kinase (WIPK) are rapidly activated after perception of herbivory and both kinases regulate herbivory-induced JA levels and JA-mediated defense metabolite accumulations. Since JA-induced defenses result in resource-based trade-offs that compromise plant productivity, we evaluated if silencing SIPK (irSIPK) and WIPK (irWIPK) benefits the growth and fitness of plants competiting with wild type (WT) plants, as has been shown for plants silenced in JA-signaling by the reduction of Lipoxygenase 3 (LOX3) levels. Results As expected, irWIPK and LOX3-silenced plants out-performed their competing WT plants. Surprisingly, irSIPK plants, which have the largest reductions in JA signaling, did not. Phytohormone profiling of leaves revealed that irSIPK plants accumulated higher levels of SA compared to WT. To test the hypothesis that these high levels of SA, and their presumed associated fitness costs of pathogen associated defenses in irSIPK plants had nullified the JA-deficiency-mediated growth benefits in these plants, we genetically reduced SA levels in irSIPK plants. Reducing SA levels partially recovered the biomass and fitness deficits of irSIPK plants. We also evaluated whether the increased fitness of plants with reduced SA or JA levels resulted from

Two bHLH-type transcription factors, JA-ASSOCIATED MYC2-LIKE2 and JAM3, are transcriptional repressors and affect male fertility

PubMed Central

Nakata, Masaru; Ohme-Takagi, Masaru

2013-01-01

The jasmonate (JA) plant hormones regulate responses to biotic and abiotic stress and aspects of plant development, including male fertility in Arabidopsis thaliana. The bHLH-type transcription factor JA-ASSOCIATED MYC2-LIKE1 (JAM1) negatively regulates JA signaling and gain-of-function JAM1 transgenic plants have impaired JA-mediated male fertility. Here we report that JAM2 and JAM3, 2 bHLHs closely related to JAM1, also act as transcriptional repressors. Moreover, overexpression of JAM2 and JAM3 also results in reduced male fertility. These results suggest that JAM1, JAM2, and JAM3 act redundantly as negative regulators of JA-mediated male fertility. PMID:24056034

Launching and Undergraduate Earth System Science Curriculum with a Focus on Global Sustainability: the Loma Linda University Experience

NASA Astrophysics Data System (ADS)

Ford, R. E.; Dunbar, S. G.; Soret, S.; Wiafe, S.; Gonzalez, D.; Rossi, T.

2004-12-01

The vision of the School of Science and Technology (SST) at Loma Linda University (LLU) is to develop an interdisciplinary approach to doing science that bridges the social, biological, earth, and health sciences. It will provide opportunities for undergraduate, graduate, and professional students to apply new tools and concepts to the promotion of global service and citizenship while addressing issues of global poverty, health and disease, environmental degradation, poverty, and social inequality. A primary teaching strategy will be to involve students with faculty in applied field social and science policy research on "global sustainability" issues and problems in real places such as Fiji, Jamaica, Honduras, Bahamas, East Africa, and the US southwest (Great Basin, Salton Sea, coastal California, southern Utah). Recently we became a partner in the NASA/USRA ESSE21 Project (Earth System Science Education for the 21st Century). We bring to that consortium strengths and experience in areas such as social policy, sustainable development, medicine, environmental health, disaster mitigation, humanitarian relief, geoinformatics and bioinformatics. This can benefit ESSE21, the NASA Earth Enterprise Mission, and the wider geosciences education community by demonstrating the relevance of such tools, and methods outside the geosciences. Many of the graduate and undergraduate students who will participate in the new program come from around the world while many others represent underserved populations in the United States. The PI and Co-PIs have strong global as well as domestic experience serving underrepresented communities, e.g. Seth Wiafe from Ghana, Sam Soret from Spain, Stephen Dunbar from the South Pacific, and Robert Ford from Latin America and Africa. Our partnership in implementation will include other institutions such as: La Sierra University, the California State University, Pomona, Center for Geographic Information Science Research, ESRI, Inc., the University of

Physiological Characteristics and Production of Folic Acid of Lactobacillus plantarum JA71 Isolated from Jeotgal, a Traditional Korean Fermented Seafood

PubMed Central

Lim, Sang-Dong

2014-01-01

Folic acid, one of the B group of vitamins, is an essential substance for maintaining the functions of the nervous system, and is also known to decrease the level of homocysteine in plasma. Homocysteine influences the lowering of the cognitive function in humans, and especially in elderly people. In order to determine the strains with a strong capacity to produce folic acid, 190 bacteria were isolated from various kinds of jeotgal and chungkuk-jang. In our test experiment, JA71 was found to contain 9.03μg/mL of folic acid after 24 h of incubation in an MRS broth. This showed that JA71 has the highest folic acid production ability compared to the other lactic acid bacteria that were isolated. JA71 was identified as Lactobacillus plantarum by the result of API carbohydrate fermentation pattern and 16s rDNA sequence. JA71 was investigated for its physiological characteristics. The optimum growth temperature of JA71 was 37℃, and the cultures took 12 h to reach pH 4.4. JA71 proved more sensitive to bacitracin when compared with fifteen different antibiotics, and showed most resistance to neomycin and vancomycin. Moreover, it was comparatively tolerant of bile juice and acid, and displayed resistance to Escherichia coli, Salmonella Typhimurium, and Staphylococcus aureus with restraint rates of 60.4%, 96.7%, and 76.2%, respectively. These results demonstrate that JA71 could be an excellent strain for application to functional products. PMID:26760752

Application of a JA-Ile Biosynthesis Inhibitor to Methyl Jasmonate-Treated Strawberry Fruit Induces Upregulation of Specific MBW Complex-Related Genes and Accumulation of Proanthocyanidins.

PubMed

Delgado, Laura D; Zúñiga, Paz E; Figueroa, Nicolás E; Pastene, Edgar; Escobar-Sepúlveda, Hugo F; Figueroa, Pablo M; Garrido-Bigotes, Adrián; Figueroa, Carlos R

2018-06-13

Fleshy fruits are an important source of anthocyanins and proanthocyanidins (PAs), which protect plants against stress, and their consumption provides beneficial effects for human health. In strawberry fruit, the application of exogenous methyl jasmonate (MeJA) upregulates anthocyanin accumulation, although the relationship between the jasmonate pathway and anthocyanin and PA biosynthesis in fruits remains to be understood. Anthocyanin and PA accumulation is mainly regulated at the transcriptional level through R2R3-MYB and bHLH transcription factors in different plant species and organs. Here, the effect of jarin-1, a specific inhibitor of bioactive JA (jasmonoyl-isoleucine, JA-Ile) biosynthesis, on anthocyanin and PA accumulation was evaluated during strawberry ( Fragaria × ananassa ) fruit development using an in vitro ripening system for 48 h. Also, we observed the effects of MeJA and the application of jarin-1 to MeJA-treated fruits (MeJA + jarin-1 treatment). We assessed changes of expression levels for the JA-Ile and MeJA biosynthetic ( FaJAR1.2 and FaJMT ), JA signaling-related ( FaMYC2 and FaJAZ1 ), MYB-bHLH-WD40 (MBW) complex-related ( FabHLH3/33 , FaMYB9/10/11 , and repressor FaMYB1 ), and anthocyanin and PA biosynthetic (FaANS , FaUFGT , FaANR , and FaLAR ) genes. In addition, the promoter region of MBW complex-related MYB genes was isolated and sequenced. We found a higher redness of strawberry fruit skin and anthocyanin content in MeJA-treated fruits with respect to jarin-1-treated ones concomitant with an upregulation of FaANS and FaUFGT genes. Inversely, the PA content was higher in jarin-1- and MeJA + jarin-1-treated than in MeJA-treated fruits. MeJA + jarin-1 treatment resulted in an upregulation of FaANR and associated transcription factors such as FabHLH33 and FaMYB9/11 along with FaJMT and FaJAR1.2 . Finally, we found JA-responsive elements in the promoter regions of FaMYB1/9/10/11 genes. It is proposed that PA biosynthesis-related genes

External versus Intuitive Reasoning: The Conjunction Fallacy in Probability Judgment.

DTIC Science & Technology

1983-06-01

tions. Linda is a teacher in elementary school . Linda works in a bookstore and takes Yoga classes. Linda is active in the feminist movement. (F) Linda...sophisticated group consisted of PhD students in the decision science program of the Stanford Busi- ness School , all with several advanced courses in... mind by seemingly incon- sequential cues. There is a contrast worthy of note between the effectiveness of exten- sional cues in the health-survey

JA, a new type of polyunsaturated fatty acid isolated from Juglans mandshurica Maxim, limits the survival and induces apoptosis of heptocarcinoma cells.

PubMed

Gao, Xiu-Li; Lin, Hua; Zhao, Wei; Hou, Ya-Qin; Bao, Yong-Li; Song, Zhen-Bo; Sun, Lu-Guo; Tian, Shang-Yi; Liu, Biao; Li, Yu-Xin

2016-03-01

Juglans mandshurica Maxim (Juglandaceae) is a famous folk medicine for cancer treatment and some natural compounds isolated from it have been studied extensively. Previously we isolated a type of ω-9 polyunsaturated fatty acid (JA) from the bark of J. mandshurica, however little is known about its activity and the underlying mechanisms. In this study, we studied anti-tumor activity of JA on several human cancer cell lines. Results showed that JA is cytotoxic to HepG2, MDA-MB-231, SGC-7901, A549 and Huh7 cells at a concentration exerting minimal toxic effects on L02 cells. The selective toxicity of JA was better than other classical anti-cancer drugs. Further investigation indicated that JA could induce cell apoptosis, characterized by chromatin condensation, DNA fragmentation and activation of the apoptosis-associated proteins such as Caspase-3 and PARP-1. Moreover, we investigated the cellular apoptosis pathway involved in the apoptosis process in HepG2 cells. We found that proteins involved in mitochondrion (cleaved-Caspase-9, Apaf-1, HtrA2/Omi, Bax, and Mitochondrial Bax) and endocytoplasmic reticulum (XBP-1s, GRP78, cleaved-Caspase-7 and cleaved-Caspase-12) apoptotic pathways were up-regulated when cells were treated by JA. In addition, a morphological change in the mitochondrion was detected. Furthermore, we found that JA could inhibit DNA synthesis and induce G2/M cell cycle arrest. The expression of G2-to-M transition related proteins, such as CyclinB1 and phosphorylated-CDK1, were reduced. In contrast, the G2-to-M inhibitor p21 was increased in JA-treated cells. Overall, our results suggest that JA can induce mitochondrion- and endocytoplasmic reticulum-mediated apoptosis, and G2/M phase arrest in HepG2 cells, making it a promising therapeutic agent against hepatoma.

The tomato res mutant which accumulates JA in roots in non-stressed conditions restores cell structure alterations under salinity.

PubMed

Garcia-Abellan, José O; Fernandez-Garcia, Nieves; Lopez-Berenguer, Carmen; Egea, Isabel; Flores, Francisco B; Angosto, Trinidad; Capel, Juan; Lozano, Rafael; Pineda, Benito; Moreno, Vicente; Olmos, Enrique; Bolarin, Maria C

2015-11-01

Jasmonic acid (JA) regulates a wide spectrum of plant biological processes, from plant development to stress defense responses. The role of JA in plant response to salt stress is scarcely known, and even less known is the specific response in root, the main plant organ responsible for ionic uptake and transport to the shoot. Here we report the characterization of the first tomato (Solanum lycopersicum) mutant, named res (restored cell structure by salinity), that accumulates JA in roots prior to exposure to stress. The res tomato mutant presented remarkable growth inhibition and displayed important morphological alterations and cellular disorganization in roots and leaves under control conditions, while these alterations disappeared when the res mutant plants were grown under salt stress. Reciprocal grafting between res and wild type (WT) (tomato cv. Moneymaker) indicated that the main organ responsible for the development of alterations was the root. The JA-signaling pathway is activated in res roots prior to stress, with transcripts levels being even higher in control condition than in salinity. Future studies on this mutant will provide significant advances in the knowledge of JA role in root in salt-stress tolerance response, as well as in the energy trade-off between plant growth and response to stress. © 2015 Scandinavian Plant Physiology Society.

NtWRKY-R1, a Novel Transcription Factor, Integrates IAA and JA Signal Pathway under Topping Damage Stress in Nicotiana tabacum

PubMed Central

Jin, Weihuan; Zhou, Qi; Wei, Yuanfang; Yang, Jinmiao; Hao, Fengsheng; Cheng, Zhipeng; Guo, Hongxiang; Liu, Weiqun

2018-01-01

Topping damage can induce the nicotine synthesis in tobacco roots, which involves the activation of JA and auxin signal transduction. It remains unclear how these hormone signals are integrated to regulate nicotine synthesis. Here we isolated a transcription factor NtWRKY-R1 from the group IIe of WRKY family and it had strong negative correlation with the expression of putrescine N-methyltransferase, the key enzyme of nicotine synthesis pathway. NtWRKY-R1 was specifically and highly expressed in tobacco roots, and it contains two transcriptional activity domains in the N- and C-terminal. The promoter region of NtWRKY-R1 contains two cis-elements which are responding to JA and auxin signals, respectively. Deletion of NtWRKY-R1 promoter showed that JA and auxin signals were subdued by NtWRKY-R1, and the expression of NtWRKY-R1 was more sensitive to auxin than JA. Furthermore, Yeast two-hybrid experiment demonstrated that NtWRKY-R1 can interact with the actin-binding protein. Our data showed that the intensity of JA and auxin signals can be translated into the expression of NtWRKY-R1, which regulates the balance of actin polymerization and depolymerization through binding actin-binding protein, and then regulates the expression of genes related to nicotine synthesis. The results will help us better understand the function of the WRKY-IIe family in the signaling crosstalk of JA and auxin under damage stress. PMID:29379516

Transcriptome Analysis of ABA/JA-Dual Responsive Genes in Rice Shoot and Root.

PubMed

Kim, Jin-Ae; Bhatnagar, Nikita; Kwon, Soon Jae; Min, Myung Ki; Moon, Seok-Jun; Yoon, In Sun; Kwon, Taek-Ryoun; Kim, Sun Tae; Kim, Beom-Gi

2018-01-01

The phytohormone abscisic acid (ABA) enables plants to adapt to adverse environmental conditions through the modulation of metabolic pathways and of growth and developmental programs. We used comparative microarray analysis to identify genes exhibiting ABA-dependent expression and other hormone-dependent expression among them in Oryza sativa shoot and root. We identified 854 genes as significantly up- or down-regulated in root or shoot under ABA treatment condition. Most of these genes had similar expression profiles in root and shoot under ABA treatment condition, whereas 86 genes displayed opposite expression responses in root and shoot. To examine the crosstalk between ABA and other hormones, we compared the expression profiles of the ABA-dependently regulated genes under several different hormone treatment conditions. Interestingly, around half of the ABA-dependently expressed genes were also regulated by jasmonic acid based on microarray data analysis. We searched the promoter regions of these genes for cis-elements that could be responsible for their responsiveness to both hormones, and found that ABRE and MYC2 elements, among others, were common to the promoters of genes that were regulated by both ABA and JA. These results show that ABA and JA might have common gene expression regulation system and might explain why the JA could function for both abiotic and biotic stress tolerance.

Integrated metabolomic and proteomic analysis reveals systemic responses of Rubrivivax benzoatilyticus JA2 to aniline stress.

PubMed

Mujahid, Md; Prasuna, M Lakshmi; Sasikala, Ch; Ramana, Ch Venkata

2015-02-06

Aromatic amines are widely distributed in the environment and are major environmental pollutants. Although degradation of aromatic amines is well studied in bacteria, physiological adaptations and stress response to these toxic compounds is not yet fully understood. In the present study, systemic responses of Rubrivivax benzoatilyticus JA2 to aniline stress were deciphered using metabolite and iTRAQ-labeled protein profiling. Strain JA2 tolerated high concentrations of aniline (30 mM) with trace amounts of aniline being transformed to acetanilide. GC-MS metabolite profiling revealed aniline stress phenotype wherein amino acid, carbohydrate, fatty acid, nitrogen metabolisms, and TCA (tricarboxylic acid cycle) were modulated. Strain JA2 responded to aniline by remodeling the proteome, and cellular functions, such as signaling, transcription, translation, stress tolerance, transport and carbohydrate metabolism, were highly modulated. Key adaptive responses, such as transcription/translational changes, molecular chaperones to control protein folding, and efflux pumps implicated in solvent extrusion, were induced in response to aniline stress. Proteo-metabolomics indicated extensive rewiring of metabolism to aniline. TCA cycle and amino acid catabolism were down-regulated while gluconeogenesis and pentose phosphate pathways were up-regulated, leading to the synthesis of extracellular polymeric substances. Furthermore, increased saturated fatty acid ratios in membranes due to aniline stress suggest membrane adaptation. The present study thus indicates that strain JA2 employs multilayered responses: stress response, toxic compound tolerance, energy conservation, and metabolic rearrangements to aniline.

Improving Interagency Coordination and Unity of Effort: An Organizational Analysis of the Contemporary Provincial Reconstruction Team

DTIC Science & Technology

2010-05-20

capability. A DOS PRT member, Linda Specht , recalls that: The contemporary PRT hierarchical organization achieves such integration and accountability...Linda Specht , 4 February 2008" (Fort Leavenworth, Kansas: Combat Studies Institute, 2008), 9, http://comarms.ipac.dynixasp.com/ipac20/ipac. jsp...term=interview+with+linda+ specht &index=.GW#focus (accessed February 10, 2010). Figure 2 represents the cross-functional contemporary PRT organization

JaK/STAT Inhibition to Prevent Post-Traumatic Epileptogenesis

DTIC Science & Technology

2013-07-31

months 22-28) 2i. Assess mossy fiber sprouting, cell loss and glial proliferation 10 weeks post injury using Timm and Nissl staining (40 mice...1e. Assess protein levels and regional/cellular expression of JaK1 and 2, pSTAT1-5 using fluorescent immunohistochemistry with co- staining for cell...treated with CCI, 10 of which were treated with WP1066. Early post-injury experiments are underway; Timm staining has not revealed mossy fiber

OsMPK3 positively regulates the JA signaling pathway and plant resistance to a chewing herbivore in rice.

PubMed

Wang, Qi; Li, Jiancai; Hu, Lingfei; Zhang, Tongfang; Zhang, Guren; Lou, Yonggen

2013-07-01

KEY MESSAGE : Silencing OsMPK3 decreased elicited JA levels, which subsequently reduced levels of herbivore-induced trypsin protease inhibitors (TrypPIs) and improved the performance of SSB larvae, but did not influence BPH. Mitogen-activated protein kinases (MPKs) are known to play an important role in plant defense by transferring biotic and abiotic signals into programmed cellular responses. However, their functions in the herbivore-induced defense response in rice remain largely unknown. Here, we identified a MPK3 gene from rice, OsMPK3, and found that its expression levels were up-regulated in response to infestation by the larvae of the striped stem borer (SSB) (Chilo suppressalis), to mechanical wounding and to treatment with jasmonic acid (JA), but not to infestation by the brown planthopper (BPH) Nilaparvata lugens or to treatment with salicylic acid. Moreover, mechanical wounding and SSB infestation induced the expression of OsMPK3 strongly and quickly, whereas JA treatment induced the gene more weakly and slowly. Silencing OsMPK3 (ir-mpk3) reduced the expression of the gene by 50-70 %, decreased elicited levels of JA and diminished the expression of a lipoxygenase gene OsHI-LOX and an allene oxide synthase gene OsAOS1. The reduced JA signaling in ir-mpk3 plants decreased the levels of herbivore-induced trypsin protease inhibitors (TrypPIs) and improved the performance of SSB larvae, but did not influence BPH. Our findings suggest that the gene OsMPK3 responds early in herbivore-induced defense and can be regulated by rice plants to activate a specific and appropriate defense response to different herbivores.

Transformation of miniature potted rose (Rosa hybrida cv. Linda) with P( SAG12 )-ipt gene delays leaf senescence and enhances resistance to exogenous ethylene.

PubMed

Zakizadeh, Hedayat; Lütken, Henrik; Sriskandarajah, Sridevy; Serek, Margrethe; Müller, Renate

2013-02-01

KEY MESSAGE : The P ( SAG12 ) -ipt gene was transferred to miniature rose, as the first woody species, resulting in increased ethylene resistance due to specific up-regulation of the ipt gene under senescence promoting conditions. Transgenic plants of Rosa hybrida 'Linda' were obtained via transformation with Agrobacterium tumefaciens strain harboring the binary vector pSG529(+) containing the P( SAG12 )-ipt construct. A. tumefaciens strains AGL1, GV3850 and LBA4404 (containing P(35S)-INTGUS gene) were used for transformation of embryogenic callus, but transgenic shoots were obtained only when AGL1 was applied. The highest transformation frequency was 10 % and it was achieved when half MS medium was used for the dilution of overnight culture of Agrobacterium. Southern blot confirmed integration of 1-6 copies of the nptII gene into the rose genome in the tested lines. Four transgenic lines were obtained which were morphologically true-to-type and indistinguishable from Wt shoots while they were in in vitro cultures. Adventitious root induction was more difficult in transgenic shoots compared to the Wt shoots, however, one of the transgenic lines (line 6) was rooted and subsequently analyzed phenotypically. The ipt expression levels were determined in this line after exposure to exogenous ethylene (3.5 μl l(-1)) and/or darkness. Darkness resulted in twofold up-regulation of ipt expression, whereas darkness combined with ethylene caused eightfold up-regulation in line 6 compared to Wt plants. The transgenic line had significantly higher content of chlorophyll at the end of the treatment period compared to Wt plants.

Metacomputing on Commodity Computers

DTIC Science & Technology

1999-05-01

on NOWs, and this has contributed to the popularity of systems such as PVM [59], MPI [67], Linda [33], and TreadMarks [2]. 26 Challenges Given that...presents the performance of Calypso and Persistent Linda (PLinda) [77] programs and compares how they can tolerate failures. A biological pattern...adds fault tolerance to Linda programs by using light-weight transac- tions, whereas Calypso uses the combination of eager scheduling and two-phase

Stable Isotope-Assisted Metabolic Profiling Reveals Growth Mode Dependent Differential Metabolism and Multiple Catabolic Pathways of l-Phenylalanine in Rubrivivax benzoatilyticus JA2.

PubMed

Mekala, Lakshmi Prasuna; Mohammed, Mujahid; Chintalapati, Sasikala; Chintalapati, Venkata Ramana

2018-01-05

Anoxygenic phototrophic bacteria are metabolically versatile and survive under different growth modes using diverse organic compounds, yet their metabolic diversity is largely unexplored. In the present study, we employed stable-isotope-assisted metabolic profiling to unravel the l-phenylalanine catabolism in Rubrivivax benzoatilyticus JA2 under varying growth modes. Strain JA2 grows under anaerobic and aerobic conditions by utilizing l-phenylalanine as a nitrogen source. Furthermore, ring-labeled 13 C 6 -phenylalanine feeding followed by liquid chromatography-mass spectrometry exometabolite profiling revealed 60 labeled metabolic features (M + 6, M + 12, and M + 18) derived solely from l-phenylalanine, of which 11 were identified, 7 putatively identified, and 42 unidentified under anaerobic and aerobic conditions. However, labeled metabolites were significantly higher in aerobic compared to anaerobic conditions. Furthermore, detected metabolites and enzyme activities indicated multiple l-phenylalanine catabolic routes mainly Ehrlich, homogentisate-dependent melanin, benzenoid, and unidentified pathways operating under anaerobic and aerobic conditions in strain JA2. Interestingly, the study indicated l-phenylalanine-dependent and independent benzenoid biosynthesis in strain JA2 and a differential flux of l-phenylalanine to Ehrlich and benzenoid pathways under anaerobic and aerobic conditions. Additionally, unidentified labeled metabolites strongly suggest the presence of unknown phenylalanine catabolic routes in strain JA2. Overall, the study uncovered the l-phenylalanine catabolic diversity in strain JA2 and demonstrated the potential of stable isotope-assisted metabolomics in unraveling the hidden metabolic repertoire.

Parallel computation for biological sequence comparison: comparing a portable model to the native model for the Intel Hypercube.

PubMed Central

Nadkarni, P. M.; Miller, P. L.

1991-01-01

A parallel program for inter-database sequence comparison was developed on the Intel Hypercube using two models of parallel programming. One version was built using machine-specific Hypercube parallel programming commands. The other version was built using Linda, a machine-independent parallel programming language. The two versions of the program provide a case study comparing these two approaches to parallelization in an important biological application area. Benchmark tests with both programs gave comparable results with a small number of processors. As the number of processors was increased, the Linda version was somewhat less efficient. The Linda version was also run without change on Network Linda, a virtual parallel machine running on a network of desktop workstations. PMID:1807632

Parallel computation for biological sequence comparison: comparing a portable model to the native model for the Intel Hypercube.

PubMed

Nadkarni, P M; Miller, P L

1991-01-01

A parallel program for inter-database sequence comparison was developed on the Intel Hypercube using two models of parallel programming. One version was built using machine-specific Hypercube parallel programming commands. The other version was built using Linda, a machine-independent parallel programming language. The two versions of the program provide a case study comparing these two approaches to parallelization in an important biological application area. Benchmark tests with both programs gave comparable results with a small number of processors. As the number of processors was increased, the Linda version was somewhat less efficient. The Linda version was also run without change on Network Linda, a virtual parallel machine running on a network of desktop workstations.

Aniline Is an Inducer, and Not a Precursor, for Indole Derivatives in Rubrivivax benzoatilyticus JA2

PubMed Central

Mohammed, Mujahid; Ch, Sasikala; Ch, Ramana V.

2014-01-01

Rubrivivax benzoatilyticus JA2 and other anoxygenic photosynthetic bacteria produce indole derivatives when exposed to aniline, a xenobiotic compound. Though this phenomenon has been reported previously, the role of aniline in the production of indoles is still a biochemical riddle. The present study aims at understanding the specific role of aniline (as precursor or stimulator) in the production of indoles and elucidating the biochemical pathway of indoles in aniline-exposed cells by using stable isotope approaches. Metabolic profiling revealed tryptophan accumulation only in aniline exposed cells along with indole 3-acetic acid (IAA) and indole 3-aldehyde (IAld), the two major catabolites of tryptophan. Deuterium labelled aniline feeding studies revealed that aniline is not a precursor of indoles in strain JA2. Further, production of indoles only in aniline-exposed cells suggests that aniline is an indoles stimulator. In addition, production of indoles depended on the presence of a carbon source, and production enhanced when carbon sources were added to the culture. Isotope labelled fumarate feeding identified, fumarate as the precursor of indole, indicating de novo synthesis of indoles. Glyphosate (shikimate pathway inhibitor) inhibited the indoles production, accumulation of tryptophan, IAA and IAld indicating that indoles synthesis in strain JA2 occurs via the de novo shikimate pathway. The up-regulation of anthranilate synthase gene and induction of anthranilate synthase activity correlated well with tryptophan production in strain JA2. Induction of tryptophan aminotransferase and tryptophan 2-monooxygenase activities corroborated well with IAA levels, suggesting that tryptophan catabolism occurs simultaneously in aniline exposed cells. Our study demonstrates that aniline (stress) stimulates tryptophan/indoles synthesis via the shikimate pathway by possibly modulating the metabolic pathway. PMID:24533057

Aniline is an inducer, and not a precursor, for indole derivatives in Rubrivivax benzoatilyticus JA2.

PubMed

Mujahid, Mohammed; Sasikala, Ch; Ramana, Ch V

2014-01-01

Rubrivivax benzoatilyticus JA2 and other anoxygenic photosynthetic bacteria produce indole derivatives when exposed to aniline, a xenobiotic compound. Though this phenomenon has been reported previously, the role of aniline in the production of indoles is still a biochemical riddle. The present study aims at understanding the specific role of aniline (as precursor or stimulator) in the production of indoles and elucidating the biochemical pathway of indoles in aniline-exposed cells by using stable isotope approaches. Metabolic profiling revealed tryptophan accumulation only in aniline exposed cells along with indole 3-acetic acid (IAA) and indole 3-aldehyde (IAld), the two major catabolites of tryptophan. Deuterium labelled aniline feeding studies revealed that aniline is not a precursor of indoles in strain JA2. Further, production of indoles only in aniline-exposed cells suggests that aniline is an indoles stimulator. In addition, production of indoles depended on the presence of a carbon source, and production enhanced when carbon sources were added to the culture. Isotope labelled fumarate feeding identified, fumarate as the precursor of indole, indicating de novo synthesis of indoles. Glyphosate (shikimate pathway inhibitor) inhibited the indoles production, accumulation of tryptophan, IAA and IAld indicating that indoles synthesis in strain JA2 occurs via the de novo shikimate pathway. The up-regulation of anthranilate synthase gene and induction of anthranilate synthase activity correlated well with tryptophan production in strain JA2. Induction of tryptophan aminotransferase and tryptophan 2-monooxygenase activities corroborated well with IAA levels, suggesting that tryptophan catabolism occurs simultaneously in aniline exposed cells. Our study demonstrates that aniline (stress) stimulates tryptophan/indoles synthesis via the shikimate pathway by possibly modulating the metabolic pathway.

Environmental Analysis of Lake Pontchartrain, Louisiana, Its Surrounding Wetlands, and Selected Land Uses. Volume 1.

DTIC Science & Technology

1980-02-01

M. Darnell,* Richard W. Heard,* Robert C. Cashner,* and Olivia House* e Graduate Modeling Robert E. Hinchee and Linda A. Deegan Students Grassbeds...James H. Stone, B. T. Gael, Linda A. Deegan , Robert E. Hinchee, John W. Day, Jr., Leonard M. Bahr, Jr., and R. E. Turner R. C. Cashner is affiliated with...Sciences Linda A. Deegan , Graduate Assistant David D. Dow, Research Associate III Nancy A. Drummond, Graduate Assistant Marion Fannaly, Research Associate

Uterine artery embolization - discharge

MedlinePlus

... Kauh C. Complications of gynecological procedures, abortion, and assisted reproductive technology. In: Adams JG, ed. ... of Obstetrics and Gynecology, Loma Linda University School of Medicine, Loma Linda Center for Fertility, Loma ...

Genome Analysis of the Biotechnologically Relevant Acidophilic Iron Oxidising Strain JA12 Indicates Phylogenetic and Metabolic Diversity within the Novel Genus “Ferrovum”

PubMed Central

Ullrich, Sophie R.; Poehlein, Anja; Tischler, Judith S.; González, Carolina; Ossandon, Francisco J.; Daniel, Rolf; Holmes, David S.; Schlömann, Michael; Mühling, Martin

2016-01-01

Background Members of the genus “Ferrovum” are ubiquitously distributed in acid mine drainage (AMD) waters which are characterised by their high metal and sulfate loads. So far isolation and microbiological characterisation have only been successful for the designated type strain “Ferrovum myxofaciens” P3G. Thus, knowledge about physiological characteristics and the phylogeny of the genus “Ferrovum” is extremely scarce. Objective In order to access the wider genetic pool of the genus “Ferrovum” we sequenced the genome of a “Ferrovum”-containing mixed culture and successfully assembled the almost complete genome sequence of the novel “Ferrovum” strain JA12. Phylogeny and Lifestyle The genome-based phylogenetic analysis indicates that strain JA12 and the type strain represent two distinct “Ferrovum” species. “Ferrovum” strain JA12 is characterised by an unusually small genome in comparison to the type strain and other iron oxidising bacteria. The prediction of nutrient assimilation pathways suggests that “Ferrovum” strain JA12 maintains a chemolithoautotrophic lifestyle utilising carbon dioxide and bicarbonate, ammonium and urea, sulfate, phosphate and ferrous iron as carbon, nitrogen, sulfur, phosphorous and energy sources, respectively. Unique Metabolic Features The potential utilisation of urea by “Ferrovum” strain JA12 is moreover remarkable since it may furthermore represent a strategy among extreme acidophiles to cope with the acidic environment. Unlike other acidophilic chemolithoautotrophs “Ferrovum” strain JA12 exhibits a complete tricarboxylic acid cycle, a metabolic feature shared with the closer related neutrophilic iron oxidisers among the Betaproteobacteria including Sideroxydans lithotrophicus and Thiobacillus denitrificans. Furthermore, the absence of characteristic redox proteins involved in iron oxidation in the well-studied acidophiles Acidithiobacillus ferrooxidans (rusticyanin) and Acidithiobacillus

Underrepresented Minority High School and College Students Report STEM-Pipeline Sustaining Gains After Participating in the Loma Linda University Summer Health Disparities Research Program

PubMed Central

Salto, Lorena M.; Riggs, Matt L.; Delgado De Leon, Daisy; Casiano, Carlos A.; De Leon, Marino

2014-01-01

An urgent need exists for graduate and professional schools to establish evidence-based STEM (science, technology, engineering, and math) pipeline programs to increase the diversity of the biomedical workforce. An untapped yet promising pool of willing participants are capable high school students that have a strong STEM interest but may lack the skills and the guided mentoring needed to succeed in competitive STEM fields. This study evaluates and compares the impact of the Loma Linda University (LLU) Summer Health Disparities Research Program on high school (HS) and undergraduate (UG) student participants. The primary focus of our summer research experience (SRE) is to enhance the research self-efficacy of the participants by actively involving them in a research project and by providing the students with personalized mentoring and targeted career development activities, including education on health disparities. The results of our study show that our SRE influenced terminal degree intent and increased participant willingness to incorporate research into future careers for both the HS and the UG groups. The quantitative data shows that both the HS and the UG participants reported large, statistically significant gains in self-assessed research skills and research self-efficacy. Both participant groups identified the hands-on research and the mentor experience as the most valuable aspects of our SRE and reported increased science skills, increased confidence in science ability and increased motivation and affirmation to pursue a science career. The follow-up data indicates that 67% of the HS participants and 90% of the UG participants graduated from college with a STEM degree; for those who enrolled in graduate education, 61% and 43% enrolled in LLU, respectively. We conclude that structured SREs can be highly effective STEM strengthening interventions for both UG and HS students and may be a way to measurably increase institutional and biomedical workforce

Underrepresented minority high school and college students report STEM-pipeline sustaining gains after participating in the Loma Linda University Summer Health Disparities Research Program.

PubMed

Salto, Lorena M; Riggs, Matt L; Delgado De Leon, Daisy; Casiano, Carlos A; De Leon, Marino

2014-01-01

An urgent need exists for graduate and professional schools to establish evidence-based STEM (science, technology, engineering, and math) pipeline programs to increase the diversity of the biomedical workforce. An untapped yet promising pool of willing participants are capable high school students that have a strong STEM interest but may lack the skills and the guided mentoring needed to succeed in competitive STEM fields. This study evaluates and compares the impact of the Loma Linda University (LLU) Summer Health Disparities Research Program on high school (HS) and undergraduate (UG) student participants. The primary focus of our summer research experience (SRE) is to enhance the research self-efficacy of the participants by actively involving them in a research project and by providing the students with personalized mentoring and targeted career development activities, including education on health disparities. The results of our study show that our SRE influenced terminal degree intent and increased participant willingness to incorporate research into future careers for both the HS and the UG groups. The quantitative data shows that both the HS and the UG participants reported large, statistically significant gains in self-assessed research skills and research self-efficacy. Both participant groups identified the hands-on research and the mentor experience as the most valuable aspects of our SRE and reported increased science skills, increased confidence in science ability and increased motivation and affirmation to pursue a science career. The follow-up data indicates that 67% of the HS participants and 90% of the UG participants graduated from college with a STEM degree; for those who enrolled in graduate education, 61% and 43% enrolled in LLU, respectively. We conclude that structured SREs can be highly effective STEM strengthening interventions for both UG and HS students and may be a way to measurably increase institutional and biomedical workforce

75 FR 53692 - Pesticide Products; Registration Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-01

...: Pistachio. Contact: Linda A. DeLuise, (703) 305-5428, [email protected] . 4. Registration number: 279..., buckwheat, oat, pistachio, and rye. Contact: Linda A. DeLuise, (703) 305-5428, [email protected] . List...

78 FR 69658 - Domtar Wisconsin Dam Corporation; Notice of Application To Amend License and Accepted for Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-20

... Point Basse Avenue, Nekoosa, Wisconsin 54457; telephone (715) 886-7711. i. FERC Contact: Linda Stewart at (202) 502-6680; or email at linda.stewart@ferc.gov . j. Deadline for filing comments, motions to...

The Rapid Diagnosis of Leptospirosis: A Prospective Comparison of the Dot Enzyme-Linked Immunosorbent Assay and the Genus-Specific Microscopic Agglutination Test at Different Stages of Illness

DTIC Science & Technology

1988-04-01

stages of illness. 12 09RSONAL AU’THORt(S) George WttT4y M . Aiquiza, Laurei P. Padre, Ma. Linda Tuazon, Lar,:y- W. awbi 13s. TYPE OF REPORT I ]b TIME...agglutination test at different stages of illness George Watt, Lily M , Alquiza, Laurena Padre, Ma. Linda Tuazon, and Larry W. Laughlin REPORT NO. TR...MICROSCOPIC AGGLUTINATION TEST AT DIFFERENT STAGES OF ILLNESS GLORGE WATT. LILY M . ALQUIZA, LAURENA P. PADRE. MAR! • LINDA TAUZON, and LARRY W

On the Study of Statistical Intuitions.

DTIC Science & Technology

1981-05-15

teller; 3. Linda is a bank teller who is PAGE 10 active in the feminist movement. In a large sample of statistically naive undergraduates, 86% judged...Linda is both a bank teller and an active feminist must be smaller than the probability that she is a bank teller. (ii) B is more probable than A...because Linda resembles a bank teller who is active in the feminist movement more than she resembles a bank teller. Argument (i) favoring the conjunction

Early dust formation and a massive progenitor for SN 2011ja?

NASA Astrophysics Data System (ADS)

Andrews, J. E.; Krafton, Kelsie M.; Clayton, Geoffrey C.; Montiel, E.; Wesson, R.; Sugerman, Ben E. K.; Barlow, M. J.; Matsuura, M.; Drass, H.

2016-04-01

SN 2011ja was a bright (I = -18.3) Type II supernova occurring in the nearby edge on spiral galaxy NGC 4945. Flat-topped and multipeaked H α and H β spectral emission lines appear between 64 and 84 d post-explosion, indicating interaction with a disc-like circumstellar medium inclined ˜45° from edge-on. After day 84, an increase in the H- and K-band flux along with heavy attenuation of the red wing of the emission lines are strong indications of early dust formation, likely located in the cool dense shell created between the forward shock of the SN ejecta and the reverse shock created as the ejecta plows into the existing circumstellar material. Radiative transfer modelling reveals both ≈1 × 10-5 M⊙ of pre-existing dust located ˜1016.7 cm away and up to ≈6 × 10-4 M⊙ of newly formed dust. Spectral observations after 1.5 yr reveal the possibility that the fading SN is located within a young (3-6 Myr) massive stellar cluster, which when combined with tentative 56Ni mass estimates of 0.2 M⊙ may indicate a massive (≥25 M⊙) progenitor for SN 2011ja.

Global Reach-Global Power Air Force Strategic Vision, Past and Future

DTIC Science & Technology

1995-06-01

10 Patrick E. Conner and Linda K. Lake, Managing Organizational Change (Westport, Connecticut: Praeger...Linda K. Lake. Managing Organizational Change . 2nd edition. Westport, Connecticut: Praeger, 1994. Cound, Dana M. A Leader’s Journey to Quality

New Enhanced Artificial Bee Colony (JA-ABC5) Algorithm with Application for Reactive Power Optimization

PubMed Central

2015-01-01

The standard artificial bee colony (ABC) algorithm involves exploration and exploitation processes which need to be balanced for enhanced performance. This paper proposes a new modified ABC algorithm named JA-ABC5 to enhance convergence speed and improve the ability to reach the global optimum by balancing exploration and exploitation processes. New stages have been proposed at the earlier stages of the algorithm to increase the exploitation process. Besides that, modified mutation equations have also been introduced in the employed and onlooker-bees phases to balance the two processes. The performance of JA-ABC5 has been analyzed on 27 commonly used benchmark functions and tested to optimize the reactive power optimization problem. The performance results have clearly shown that the newly proposed algorithm has outperformed other compared algorithms in terms of convergence speed and global optimum achievement. PMID:25879054

New enhanced artificial bee colony (JA-ABC5) algorithm with application for reactive power optimization.

PubMed

Sulaiman, Noorazliza; Mohamad-Saleh, Junita; Abro, Abdul Ghani

2015-01-01

The standard artificial bee colony (ABC) algorithm involves exploration and exploitation processes which need to be balanced for enhanced performance. This paper proposes a new modified ABC algorithm named JA-ABC5 to enhance convergence speed and improve the ability to reach the global optimum by balancing exploration and exploitation processes. New stages have been proposed at the earlier stages of the algorithm to increase the exploitation process. Besides that, modified mutation equations have also been introduced in the employed and onlooker-bees phases to balance the two processes. The performance of JA-ABC5 has been analyzed on 27 commonly used benchmark functions and tested to optimize the reactive power optimization problem. The performance results have clearly shown that the newly proposed algorithm has outperformed other compared algorithms in terms of convergence speed and global optimum achievement.

Biosynthesis of silver and zinc oxide nanoparticles using Pichia fermentans JA2 and their antimicrobial property

NASA Astrophysics Data System (ADS)

Chauhan, Ritika; Reddy, Arpita; Abraham, Jayanthi

2015-01-01

The development of eco-friendly alternative to chemical synthesis of metal nanoparticles is of great challenge among researchers. The present study aimed to investigate the biological synthesis, characterization, antimicrobial study and synergistic effect of silver and zinc oxide nanoparticles against clinical pathogens using Pichia fermentans JA2. The extracellular biosynthesis of silver and zinc oxide nanoparticles was investigated using Pichia fermentans JA2 isolated from spoiled fruit pulp bought in Vellore local market. The crystalline and stable metallic nanoparticles were characterized evolving several analytical techniques including UV-visible spectrophotometer, X-ray diffraction pattern analysis and FE-scanning electron microscope with EDX-analysis. The biosynthesized metallic nanoparticles were tested for their antimicrobial property against medically important Gram positive, Gram negative and fungal pathogenic microorganisms. Furthermore, the biosynthesized nanoparticles were also evaluated for their increased antimicrobial activities with various commercially available antibiotics against clinical pathogens. The biosynthesized silver nanoparticles inhibited most of the Gram negative clinical pathogens, whereas zinc oxide nanoparticles were able to inhibit only Pseudomonas aeruginosa. The combined effect of standard antibiotic disc and biosynthesized metallic nanoparticles enhanced the inhibitory effect against clinical pathogens. The biological synthesis of silver and zinc oxide nanoparticles is a novel and cost-effective approach over harmful chemical synthesis techniques. The metallic nanoparticles synthesized using Pichia fermentans JA2 possess potent inhibitory effect that offers valuable contribution to pharmaceutical associations.

Cyclic lipopeptide iturin A structure-dependently induces defense response in Arabidopsis plants by activating SA and JA signaling pathways.

PubMed

Kawagoe, Yumi; Shiraishi, Soma; Kondo, Hiroko; Yamamoto, Shoko; Aoki, Yoshinao; Suzuki, Shunji

2015-05-15

Iturin A is the most well studied antifungal cyclic lipopeptide produced by Bacillus species that are frequently utilized as biological control agents. Iturin A not only shows strong antifungal activity against phytopathogens but also induces defense response in plants, thereby reducing plant disease severity. Here we report the defense signaling pathways triggered by iturin A in Arabidopsis salicylic acid (SA) or jasmonic acid (JA)-insensitive mutants. Iturin A activated the transcription of defense genes PR1 and PDF1.2 through the SA and JA signaling pathways, respectively. The role of iturin A as an elicitor was dependent on the cyclization of the seven amino acids and/or the β-hydroxy fatty acid chain. The iturin A derivative peptide, NH2-(L-Asn)-(D-Tyr)-(D-Asn)-(L-Gln)-(L-Pro)-(D-Asn)-(L-Ser)-COOH, completely suppressed PR1 and PDF1.2 gene expression in wild Arabidopsis plants. The identification of target molecules binding to iturin A and its derivative peptide is expected to shed new light on defense response in plants through the SA and JA signaling pathways. Copyright © 2015 Elsevier Inc. All rights reserved.

QA Activities on Two Large RARE Projects at the US EPA, RTP, NC ─ from Fish to Humans

EPA Science Inventory

Two RARE (Regional Applied Research Effort) projects are being managed by Janet Diliberto, Linda Birnbaum, and Thomas Hughes. Janet is the Project Officer, Linda is the science advisor and Thomas is the QA and Records Manager for these two RARE projects. These are high visibili...

Organizational Change for Acquisition Reform: Proposed Core Competencies

DTIC Science & Technology

1997-03-01

21Patrick Connor, and Linda Lake, Managing Organizational Change (Westport, CT: Praeger, 1994), 74. Schein, 328. Tichy, 242. 22Tichy, 246. 23Conner and...Connor, Patrick and Linda Lake. Managing Organizational Change . Westport, CT: Praeger, 1994. “Cultural Shift Clutches Acquisition Work Force.” National

Pim-1: A Molecular Target to Modulate Cellular Resistance to Therapy in Prostate Cancer

DTIC Science & Technology

2006-10-01

flavonoids , has been determined. We have also shown that quercetagetin is able to inhibit the activity of the PIM1 kinase in prostate cancer cells...Adventist University, Collegedale, TN 1967-1971, B.A. (biology, chemistry ) Loma Linda University, Loma Linda, CA 1971-1975, M.D

Introduction to Retail Security.

ERIC Educational Resources Information Center

Thomas, James E., Ed.

This collection consists of 15 articles dealing with retail security. Included in the volume are the following papers: "Retail Security--an Introduction," by Andrew J. Thacker and Linda Cressman; "Systematic Planning and Retail Security," by Linda T. Thomas; "Identifying Potentially Dishonest Employees," by James E.…

Deep Sequencing Reveals the Effect of MeJA on Scutellarin Biosynthesis in Erigeron breviscapus

PubMed Central

Xiao, Ying; Zhang, Feng; Chen, Jun-feng; Ji, Qian; Tan, He-Xin; Huang, Xin; Feng, Hao; Huang, Bao-Kang; Chen, Wan-Sheng; Zhang, Lei

2015-01-01

Background Erigeron breviscapus, a well-known traditional Chinese medicinal herb, is broadly used in the treatment of cerebrovascular disease. Scutellarin, a kind of flavonoids, is considered as the material base of the pharmaceutical activities in E. breviscapus. The stable and high content of scutellarin is critical for the quality and efficiency of E. breviscapus in the clinical use. Therefore, understanding the molecular mechanism of scutellarin biosynthesis is crucial for metabolic engineering to increase the content of the active compound. However, there is virtually no study available yet concerning the genetic research of scutellarin biosynthesis in E. breviscapus. Results Using Illumina sequencing technology, we obtained over three billion bases of high-quality sequence data and conducted de novo assembly and annotation without prior genome information. A total of 182,527 unigenes (mean length = 738 bp) were found. 63,059 unigenes were functionally annotated with a cut-off E-value of 10−5. Next, a total of 238 (200 up-regulated and 38 down-regulated genes) and 513 (375 up-regulated and 138 down-regulated genes) differentially expressed genes were identified at different time points after methyl jasmonate (MeJA) treatment, which fell into categories of ‘metabolic process’ and ‘cellular process’ using GO database, suggesting that MeJA-induced activities of signal pathway in plant mainly led to re-programming of metabolism and cell activity. In addition, 13 predicted genes that might participate in the metabolism of flavonoids were found by two co-expression analyses in E. breviscapus. Conclusions Our study is the first to provide a transcriptome sequence resource for E. breviscapus plants after MeJA treatment and it reveals transcriptome re-programming upon elicitation. As the result, several putative unknown genes involved in the metabolism of flavonoids were predicted. These data provide a valuable resource for the genetic and genomic studies of

Proceedings of the Conference on the Design of Experiments in Army Research Development and Testing (34th) Held in Las Cruces, New Mexico on 19-21 October 1988

DTIC Science & Technology

1989-07-01

Webb and Linda L.C. Moss.............,,...,....., 27 COMPARISON OF RELIABILITY CONFIDENCE INTERVALS Paul H . Thrasher. ......... . 0 1...Webb and Linda L.C. Moss, U.S. Army Ballistic Research Laboratory COMPARISON OF RELIABILITY CONFIDENCE INTERVALS Paul H. Thrasher, White Sands Missile...RELEVANT Paul H. Thrasher, White Sands Missile Range 0930 - 1000 BREAK 1000 - 1130 GENERAL SESSION III Chairperson: Douglas B. Tang, Valter Reed Army

Environmental Risk Assessment and Dredged Material Management: Issues and Application

DTIC Science & Technology

1998-12-01

Co-Chair Jeff Ward Peter Seligman John Wakeman Mark Siipola Chapter 2 Exposure Assessment Workgroup Summary 13 Effects Assessment Workgroup...Doug Nester Dick Peddicord - Co-Chair Mark Reiss Brian Ross Linda Schmeising Patrick Sheehan Leanne Stahl Donna Vorhees - Co-Chair Bill Wild...STATION ES-Q 3909 HALLS FERRY ROAD VICKSBURG MS 39180-6199 601-634-3874/3129 ruizc@exl .wes.army.mil LINDA SCHMEISING PTI ENVIRONMENTAL SERVICES

Clinical Investigation Program Annual Progress Report

DTIC Science & Technology

1989-10-01

Investigators: Linda K. Kullama, Ph.D., Dr. Kenneth T. Nakamura,MD; Dr. Venkataraman Balaraman, MD, Wayne M. Ichimura, Biomedical Engineer. Department/Section...Investigators: John R. Claybaugh, Ph.D.; Kenneth T. Nakamura, MD; Dr. Venkataraman Balaraman, M.D. Department/Section: Clinical Investigation/Physiology Key...Pigs and Rats Principal ’Investigator: Linda K. Kullama, Ph.D.; John R. Claybaugh, Ph.D. Associate Investigators: Dr. Venkataraman Balaraman, M.D.; Dr

Effects of Redundant Alerts on Platoon Leader Performance and Decision Making

DTIC Science & Technology

2007-04-01

Effects of Redundant Alerts on Platoon Leader Performance and Decision Making by Andrea S . Krausman, Rodger A. Pettitt, and Linda R. Elliott...and Decision Making Andrea S . Krausman, Rodger A. Pettitt, and Linda R. Elliott Human Research and Engineering Directorate, ARL...Decision Making 5c. PROGRAM ELEMENT NUMBER 5d. PROJECT NUMBER 62716AH70 5e. TASK NUMBER 6. AUTHOR( S ) Andrea S . Krausman, Rodger A

The Combined Effects of Ethylene and MeJA on Metabolic Profiling of Phenolic Compounds in Catharanthus roseus Revealed by Metabolomics Analysis

PubMed Central

Liu, Jia; Liu, Yang; Wang, Yu; Zhang, Zhong-Hua; Zu, Yuan-Gang; Efferth, Thomas; Tang, Zhong-Hua

2016-01-01

Phenolic compounds belong to a class of secondary metabolites and are implicated in a wide range of responsive mechanisms in plants triggered by both biotic and abiotic elicitors. In this study, we approached the combinational effects of ethylene and MeJA (methyl jasmonate) on phenolic compounds profiles and gene expressions in the medicinal plant Catharanthus roseus. In virtue of a widely non-targeted metabolomics method, we identified a total of 34 kinds of phenolic compounds in the leaves, composed by 7 C6C1-, 11 C6C3-, and 16 C6C3C6 compounds. In addition, 7 kinds of intermediates critical for the biosynthesis of phenolic compounds and alkaloids were identified and discussed with phenolic metabolism. The combinational actions of ethylene and MeJA effectively promoted the total phenolic compounds, especially the C6C1 compounds (such as salicylic acid, benzoic acid) and C6C3 ones (such as cinnamic acid, sinapic acid). In contrast, the C6C3C6 compounds displayed a notably inhibitory trend in this case. Subsequently, the gene-to-metabolite networks were drawn up by searching for correlations between the expression profiles of 5 gene tags and the accumulation profiles of 41 metabolite peaks. Generally, we provide an insight into the controlling mode of ethylene-MeJA combination on phenolic metabolism in C. roseus leaves. PMID:27375495

The Combined Effects of Ethylene and MeJA on Metabolic Profiling of Phenolic Compounds in Catharanthus roseus Revealed by Metabolomics Analysis.

PubMed

Liu, Jia; Liu, Yang; Wang, Yu; Zhang, Zhong-Hua; Zu, Yuan-Gang; Efferth, Thomas; Tang, Zhong-Hua

2016-01-01

Phenolic compounds belong to a class of secondary metabolites and are implicated in a wide range of responsive mechanisms in plants triggered by both biotic and abiotic elicitors. In this study, we approached the combinational effects of ethylene and MeJA (methyl jasmonate) on phenolic compounds profiles and gene expressions in the medicinal plant Catharanthus roseus. In virtue of a widely non-targeted metabolomics method, we identified a total of 34 kinds of phenolic compounds in the leaves, composed by 7 C6C1-, 11 C6C3-, and 16 C6C3C6 compounds. In addition, 7 kinds of intermediates critical for the biosynthesis of phenolic compounds and alkaloids were identified and discussed with phenolic metabolism. The combinational actions of ethylene and MeJA effectively promoted the total phenolic compounds, especially the C6C1 compounds (such as salicylic acid, benzoic acid) and C6C3 ones (such as cinnamic acid, sinapic acid). In contrast, the C6C3C6 compounds displayed a notably inhibitory trend in this case. Subsequently, the gene-to-metabolite networks were drawn up by searching for correlations between the expression profiles of 5 gene tags and the accumulation profiles of 41 metabolite peaks. Generally, we provide an insight into the controlling mode of ethylene-MeJA combination on phenolic metabolism in C. roseus leaves.

Data Integration: Charting a Path Forward to 2035

DTIC Science & Technology

2011-02-14

New York, NY: Gotham Books, 2004. Seligman , Len. Mitre Corporation, e-mail interview, 6 Dec 2010. Singer, P.W. Wired for War: The Robotics...articles.aspx (accessed 4 Dec 2010). Ultra-Large-Scale Systems: The Software Challenge of the Future. Study lead Linda Northrup. Pittsburgh, PA: Carnegie...Virtualization?‖ 1. 41 Ultra-Large-Scale Systems: The Software Challenge of the Future. Study lead Linda Northrup. Pittsburgh, PA: Carnegie Mellon Software

Soldier-Based Assessment of a Dual-Row Tactor Display during Simultaneous Navigational and Robot-Monitoring Tasks

DTIC Science & Technology

2015-08-01

Navigational and Robot -Monitoring Tasks by Gina Pomranky-Hartnett, Linda R Elliott, Bruce JP Mortimer, Greg R Mort, Rodger A Pettitt, and Gary A...Tactor Display during Simultaneous Navigational and Robot -Monitoring Tasks by Gina Pomranky-Hartnett, Linda R Elliott, and Rodger A Pettitt...2014–31 March 2015 4. TITLE AND SUBTITLE Soldier-Based Assessment of a Dual-Row Tactor Display during Simultaneous Navigational and Robot -Monitoring

Effects of Visual, Auditory, and Tactile Alerts on Platoon Leader Performance and Decision Making

DTIC Science & Technology

2005-12-01

Effects of Visual, Auditory, and Tactile Alerts on Platoon Leader Performance and Decision Making by Andrea S . Krausman, Linda R. Elliott...Tactile Alerts on Platoon Leader Performance and Decision Making Andrea S . Krausman, Linda R. Elliott, and Rodger A. Pettitt Human Research and...Platoon Leader Performance and Decision Making 5c. PROGRAM ELEMENT NUMBER 5d. PROJECT NUMBER 62716AH70 5e. TASK NUMBER 6. AUTHOR( S

Changes in ABA, IAA and JA levels during calyx, fruit and leaves development in cape gooseberry plants (Physalis peruviana L.).

PubMed

Álvarez-Flórez, F; López-Cristoffanini, C; Jáuregui, O; Melgarejo, L M; López-Carbonell, M

2017-06-01

Changes in abscisic acid (ABA), indole-3-acetic acid (IAA) and jasmonic acid (JA) content in developing calyx, fruits and leaves of Physalis peruviana L. plants were analysed. Plant hormones have been widely studied for their roles in the regulation of various aspects related to plant development and, in particular, into their action during development and ripening of fleshly fruits. The obtained evidences suggest that the functions of these hormones are no restricted to a particular development stage, and more than one hormone is involved in controlling various aspects of plant development. Our results will contribute to understand the role of these hormones during growth and development of calyx, fruits and leaves in cape gooseberry plants. This work offers a good, quickly and efficiently protocol to extract and quantify simultaneously ABA, IAA and JA in different tissues of cape gooseberry plants. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Studies of Tissue Perfusion Failure at LAC+USCMC and the Incorporation of the Results into a National Trauma Database

DTIC Science & Technology

2005-04-01

Context Link] 29. Gibson JG, Seligman AM, Peacock WC, et al: The circulating red cell and plasma volume and the distribution of blood in large and...BS; Gandhi, Ashutosh BS; Chien, Li-Chien MD; Lu, Kevin MD; Martin, Matthew J. MD; Chan, Linda S. PhD; Demetriades, Demetrios MD, PhD; Ahmadpour...Physicians Outcome Prediction of Emergency Patients by Noninvasive Hemodynamic Monitoring* William C. Shoemaker, MD; Charles C. J. Wo, BS; Linda

Regeneration of the Adult Rat Spinal Cord in Response to Ensheathing Cells and Methylprednisolone

DTIC Science & Technology

2002-01-01

me in academics and research, and also as my friend. I thank Dr. Linda L. Porter, for her continuous efforts on my behalf as the Chairperson of...and Spinal Cord Injury Program. We are grateful to Drs. Barbara S. Bregman and Linda L. Porter for their wonderful suggestions and guidance; to Anna...ES, Pietronigro DD, Seligman ML (1980) The free radical pathology and the microcirculation in the major central nervous system disorders. Acta

The United States Army Medical Department Journal. October - December 2010

DTIC Science & Technology

2010-12-01

Fail, Just Ask Them 65 Carita DeVilbiss, PhD; Valerie J. Rice, PhD; Linda Laws; Petra Alfred Understanding the Leadership and Cultural Dimensions...educators prepared to affect the affective domain? Natl Forum Teach Educ J [serial online], 2006;16(3E):2005-2006. 17. Martin BL, Briggs LJ. The...J. Rice, PhD Linda Laws Petra Alfred ABSTRACT One method to discover possible reasons why individuals fail academic training is to ask them

Rescuing Our Warriors from Chronic Pain: A Battlefield-to-Nondeployment Means to Prevent Opioid-induced Amplification of Neuropathic Pain from Traumatic Injury

DTIC Science & Technology

2017-10-01

Amplification of Neuropathic Pain from Traumatic Injury PRINCIPAL INVESTIGATOR: Linda R. Watkins , Ph.D. CONTRACTING ORGANIZATION: Regents of the...0161 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Linda R Watkins , Ph.D. Peter M Grace, Ph.D. Suzanne M Fulgham, M.S. 5d. PROJECT NUMBER 5e. TASK...but from their action on glia cells by binding to the TLR4 receptor ( Watkins , Hutchinson, Rice, Maier, Trends Pharmacol Sci., 2009). Opioid

Sealing of Corneal Lacerations Using Photo-Activated Rose Bengal Dye and Amniotic Membrane

DTIC Science & Technology

2017-05-05

MDW/SGVU) (Contact 292-7141 for email instructions) Mar 10, 201 7 17150 3. DATE REVIEWED 4. DATE FORWARDED TO PA Mar 15, 2017 5. AUTHOR CONTACTED...REVIEWER DATE SIGNATURE OF REVIEWER Linda D Harris, GS-14, Chief, Ops Branch Mar 15, 2017 HARRIS.LINDA.OAWN.113189058 =._"::’ .. ~~;::;,..-;:_ 0...PA) Mar 21, 2017 Mar21,2017 6. COMMENTS ~ APPROVED (In compliance with security and policy review directives.) 0 DISAPPROVED PRINTED NAME, RANK

European network for Health Technology Assessment Joint Action (EUnetHTA JA): a process evaluation performed by questionnaires and documentary analysis.

PubMed

Woodford Guegan, Eleanor; Cook, Andrew

2014-06-01

The European network for Health Technology Assessment Joint Action (EUnetHTA JA) project's overarching objective was to 'establish an effective and sustainable HTA [Health technology assessment] collaboration in Europe that brings added value at the regional, national and European level'. Specific objectives were to develop a strategy and business model for sustainable European collaboration on HTA, develop HTA tools and methods and promote good practice in HTA methods and processes. We describe activities performed on behalf of the National Institute for Health Research HTA programme; evaluating the project processes and developing a data set for a registry of planned clinical studies of relevance to public funders. Annual self-completion online questionnaires were sent to project participants and external stakeholders to identify their views about the project processes. Documentary review was undertaken at the project end on the final technical reports from the work packages to examine whether or not their deliverables had been achieved. The project's impact was assessed by whether or not the deliverables were produced, the objectives met and additional 'added value' generated. The project's effectiveness was evaluated by its processes, communication, administration, workings of individual work packages and involvement of external stakeholders. A two-stage Delphi exercise was undertaken to identify the data elements that should be included in a registry of planned clinical studies of relevance to public funders. The data set was validated by an efficacy testing exercise. High response rates were achieved for the questionnaires sent to project participants and this was attributed to the evidence-based strategy implemented. Response rates to questionnaires sent to external stakeholders were disappointingly lower. Most of the high-level objectives were achieved, although applying the developed tools in practice will be implemented in the European network for Health

European network for Health Technology Assessment Joint Action (EUnetHTA JA): a process evaluation performed by questionnaires and documentary analysis.

PubMed Central

Woodford Guegan, Eleanor; Cook, Andrew

2014-01-01

BACKGROUND The European network for Health Technology Assessment Joint Action (EUnetHTA JA) project's overarching objective was to 'establish an effective and sustainable HTA [Health technology assessment] collaboration in Europe that brings added value at the regional, national and European level'. Specific objectives were to develop a strategy and business model for sustainable European collaboration on HTA, develop HTA tools and methods and promote good practice in HTA methods and processes. We describe activities performed on behalf of the National Institute for Health Research HTA programme; evaluating the project processes and developing a data set for a registry of planned clinical studies of relevance to public funders. METHODS Annual self-completion online questionnaires were sent to project participants and external stakeholders to identify their views about the project processes. Documentary review was undertaken at the project end on the final technical reports from the work packages to examine whether or not their deliverables had been achieved. The project's impact was assessed by whether or not the deliverables were produced, the objectives met and additional 'added value' generated. The project's effectiveness was evaluated by its processes, communication, administration, workings of individual work packages and involvement of external stakeholders. A two-stage Delphi exercise was undertaken to identify the data elements that should be included in a registry of planned clinical studies of relevance to public funders. The data set was validated by an efficacy testing exercise. RESULTS AND DISCUSSION High response rates were achieved for the questionnaires sent to project participants and this was attributed to the evidence-based strategy implemented. Response rates to questionnaires sent to external stakeholders were disappointingly lower. Most of the high-level objectives were achieved, although applying the developed tools in practice will be

GA3 and other signal regulators (MeJA and IAA) improve xanthumin biosynthesis in different manners in Xanthium strumarium L.

PubMed

Li, Changfu; Chen, Fangfang; Zhang, Yansheng

2014-08-25

Xanthanolides from Xanthium strumarium L. exhibit various pharmacological activities and these compounds are mainly produced in the glandular trichomes of aerial plant parts. The regulation of xanthanolide biosynthesis has never been reported in the literature. In this study, the effects of phytohormonal stimulation on xanthumin (a xanthanolide compound) biosynthesis, glandular trichomes and germacrene A synthase (GAS) gene expression in X. strumarium L. young leaves were investigated. The exogenous applications of methyl jasmonate (MeJA), indole-3-acetic acid (IAA), and gibberrellin A3 (GA3) at appropriate concentrations were all found to improve xanthumin biosynthesis, but in different ways. It was suggested that a higher gland density stimulated by MeJA (400 µM) or IAA (200 µM) treatment caused at least in part an improvement in xanthumin production, whereas GA3 (10 µM) led to an improvement by up-regulating xanthumin biosynthetic genes within gland cells, not by forming more glandular trichomes. Compared to the plants before the flowering stage, plants that had initiated flowering showed enhanced xanthumin biosynthesis, but no higher gland density, an effect was similar to that caused by exogenous GA3 treatment.

Assessment of iodine nutritional status in the general population in the province of Jaén.

PubMed

Olmedo Carrillo, Pablo; García Fuentes, Eduardo; Gutiérrez Alcántara, Carmen; Serrano Quero, Manuel; Moreno Martínez, Macarena; Ureña Fernández, Tomás; Santiago Fernández, Piedad

2015-10-01

Iodine deficiency affecting both pregnant women and schoolchildren has been reported in Jaén. Iodine deficiency is one of the leading causes of thyroid dysfunction and goiter, and adequate iodine prophylaxis with iodized salt, milk, and dairy products, or iodine supplementation have been shown to significantly improve iodine status in pregnancy. The purpose of this study was to assess iodine nutritional status in the general population of a iodine-deficient area with no previous institutional campaigns of iodine prophylaxis. A descriptive, cross-sectional study. Urinary iodine levels were measured in subjects from the Jaén healthcare district. The data were stratified by sex and age groups, and a survey was conducted on iodized salt consumption. Median and mean urinary iodine levels were 110.59 mcg/L and 130.11 mcg/L respectively. Urinary iodine levels were significantly higher in schoolchildren as compared to other age groups (161.52μg/L vs 109.33μg/L in subjects older than 65 years). Forty-three percent of the population had urinary iodine levels less than 100μg/L, and 68% of women of childbearing age had levels less than 150μg/L. Iodine nutritional status appears to be adequate, but the proportion of the population with urinary iodine levels less than 100μg/L is still very high, and iodized salt consumption is much less common than recommended by the WHO. Copyright © 2015 SEEN. Published by Elsevier España, S.L.U. All rights reserved.

RNA sequencing on Amomum villosum Lour. induced by MeJA identifies the genes of WRKY and terpene synthases involved in terpene biosynthesis.

PubMed

He, Xueying; Wang, Huan; Yang, Jinfen; Deng, Ke; Wang, Teng

2018-02-01

Amomum villosum Lour. is an important Chinese medicinal plant that has diverse medicinal functions, and mainly contains volatile terpenes. This study aims to explore the WRKY transcription factors (TFs) and terpene synthase (TPS) unigenes that might be involved in terpene biosynthesis in A. villosum, and thus providing some new information on the regulation of terpenes in plants. RNA sequencing of A. villosum induced by methyl jasmonate (MeJA) revealed that the WRKY family was the second largest TF family in the transcriptome. Thirty-six complete WRKY domain sequences were expressed in response to MeJA. Further, six WRKY unigenes were highly correlated with eight deduced TPS unigenes. Ultimately, we combined the terpene abundance with the expression of candidate WRKY TFs and TPS unigenes to presume a possible model wherein AvWRKY61, AvWRKY28, and AvWRKY40 might coordinately trans-activate the AvNeoD promoter. We propose an approach to further investigate TF unigenes that might be involved in terpenoid biosynthesis, and identified four unigenes for further analyses.

Pro Memoria. Professor Bolesław Jałowy (1906-1943): Mortui viventes obligant - the livings are obligated to the dead.

PubMed

Wincewicz, Andrzej

2016-01-01

Professor Bolesław Jałowy (1906-1943) was a chairman of Department of Histology and Embryology at Faculty of Medicine of King John Casimir University (Polish: Universytet Jana Kazimierza: UJK) in Lvov. He succeeded Professor Władysław Szymonowicz (1869-1939) who held this position for decades. As the most skillful followers of his tutor, Bolesław Jałowy was a great investigator of physiology of human tissue, embryogenesis, histological consequences of female sex hormones on blood clotting action as well as regeneration of nerves in addition to description of silver staining technique for reticulin fibers of skin. He was a hard working person with gentle attitude to such a subtle matter as microscopic structure of human body. However, he happened to live in brutal conditions of nationalistic struggles. His example shows how much a dedicated scientist could do in a very short time as his life was tragically ended with murdering him during World War Two. His story is a great lesson for generations of academic workers how to meet high moral standards with efficient and creative scientific work in evil and destructive, nationalistic climate that occurs usually in wartime.

Integrated Performance of Next Generation High Data Rate Receiver and AR4JA LDPC Codec for Space Communications

NASA Technical Reports Server (NTRS)

Cheng, Michael K.; Lyubarev, Mark; Nakashima, Michael A.; Andrews, Kenneth S.; Lee, Dennis

2008-01-01

Low-density parity-check (LDPC) codes are the state-of-the-art in forward error correction (FEC) technology that exhibits capacity approaching performance. The Jet Propulsion Laboratory (JPL) has designed a family of LDPC codes that are similar in structure and therefore, leads to a single decoder implementation. The Accumulate-Repeat-by-4-Jagged- Accumulate (AR4JA) code design offers a family of codes with rates 1/2, 2/3, 4/5 and lengths 1024, 4096, 16384 information bits. Performance is less than one dB from capacity for all combinations.Integrating a stand-alone LDPC decoder with a commercial-off-the-shelf (COTS) receiver faces additional challenges than building a single receiver-decoder unit from scratch. In this work, we outline the issues and show that these additional challenges can be over-come by simple solutions. To demonstrate that an LDPC decoder can be made to work seamlessly with a COTS receiver, we interface an AR4JA LDPC decoder developed on a field-programmable gate array (FPGA) with a modern high data rate receiver and mea- sure the combined receiver-decoder performance. Through optimizations that include an improved frame synchronizer and different soft-symbol scaling algorithms, we show that a combined implementation loss of less than one dB is possible and therefore, most of the coding gain evidence in theory can also be obtained in practice. Our techniques can benefit any modem that utilizes an advanced FEC code.

Investigation of sodium arsenite, thioacetamide, and diethanolamine in the alkaline comet assay: Part of the JaCVAM comet validation exercise.

PubMed

Beevers, Carol; Henderson, Debbie; Lillford, Lucinda

2015-07-01

As part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiative international validation study of the in vivo rat alkaline comet assay (comet assay), we examined sodium arsenite, thioacetamide, and diethanolamine. Using the JaCVAM approved study protocol version 14.2, each chemical was tested in male rats up to maximum tolerated dose levels and DNA damage in the liver and stomach was assessed approximately 3h after the final administration by gavage. Histopathology assessments of liver and stomach sections from the same animals were also examined for evidence of cytotoxicity or necrosis. No evidence of DNA damage was observed in the stomach of animals treated with sodium arsenite at 7.5, 15, or 30 mg/kg/day. However, equivocal findings were found in the liver, where increases in DNA migration were observed in two independent experiments, but not in all treated animals and not at the same dose levels. Thioacetamide caused an increase in DNA migration in the stomach of rats treated at 19, 38, and 75 mg/kg/day, but not in the liver, despite evidence of marked hepatotoxicity following histopathology assessments. No evidence of DNA damage was observed in the stomach or liver of animals treated with diethanolamine at 175, 350, or 700 mg/kg/day. Copyright © 2015 Elsevier B.V. All rights reserved.

["The madhouse" by W. Kaulbach and the meaning of the picture interpreted by J.A. Schilling, 1863].

PubMed

Rothkopf, A

1980-01-01

This article deals with the picture "Das Narrenhaus" (the Madhouse) by W. Kaulbach and its interpretation by the psychiatrist J.A. Schilling, which he gave in his book "Psychiatrische Briefe" (psychiatric letters) in 1863. This picture is often used as a contemporary document for the situation in the treatment of the mentally ill at the beginning of the last century. The article points out doubts in this procedure. The interpretation by Schilling cannot be considered a document for psychiatric records; on the contrary, it is influenced by contemporary romantic medicine and utilises the picture to exemplify the theoretical concept of culpable human offence as the cause for mental illness.

Risk of malnutrition (over and under-nutrition): validation of the JaNuS screening tool.

PubMed

Donini, Lorenzo M; Ricciardi, Laura Maria; Neri, Barbara; Lenzi, Andrea; Marchesini, Giulio

2014-12-01

Malnutrition (over and under-nutrition) is highly prevalent in patients admitted to hospital and it is a well-known risk factor for increased morbidity and mortality. Nutritional problems are often misdiagnosed, and especially the coexistence of over and undernutrition is not usually recognized. We aimed to develop and validate a screening tool for the easy detection and reporting of both undernutrition and overnutrition, specifically identifying the clinical conditions where the two types of malnutrition coexist. The study consisted of three phases: 1) selection of an appropriate study population (estimation sample) and of the hospital admission parameters to identify overnutrition and undernutrition; 2) combination of selected variables to create a screening tool to assess the nutritional risk in case of undernutrition, overnutrition, or the copresence of both the conditions, to be used by non-specialist health care professionals; 3) validation of the screening tool in a different patient sample (validation sample). Two groups of variables (12 for undernutrition, 7 for overnutrition) were identified in separate logistic models for their correlation with the outcome variables. Both models showed high efficacy, sensitivity and specificity (overnutrition, 97.7%, 99.6%, 66.6%, respectively; undernutrition, 84.4%, 83.6%, 84.8%). The logistic models were used to construct a two-faced test (named JaNuS - Just A Nutritional Screening) fitting into a two-dimension Cartesian coordinate graphic system. In the validation sample the JaNuS test confirmed its predictive value. Internal consistency and test-retest analysis provide evidence for the reliability of the test. The study provides a screening tool for the assessment of the nutritional risk, based on parameters easy-to-use by health care personnel lacking nutritional competence and characterized by excellent predictive validity. The test might be confidently applied in the clinical setting to determine the importance of

Validation of Rules to Predict Emergent Surgical Intervention in Pediatric Trauma Patients

PubMed Central

Boatright, Dowin H; Byyny, Richard L; Hopkins, Emily; Bakes, Katherine; Hissett, Jennifer; Tunson, Java; Easter, Joshua S; Vogel, Jody A; Bensard, Denis; Haukoos, Jason S

2014-01-01

Background Trauma centers use guidelines to determine when a trauma surgeon is needed in the emergency department (ED) on patient arrival. A decision rule from Loma Linda University identified patients with penetrating injury and tachycardia as requiring emergent surgical intervention. Our goal was to validate this rule and to compare it to the American College of Surgeons’ Major Resuscitation Criteria (MRC). Study Design We used data from 1993 through 2010 from two Level 1 trauma centers in Denver, Colorado. Patient demographics, injury severity, times of ED arrival and surgical intervention, and all variables of the Loma Linda Rule and the MRC were obtained. The outcome, emergent intervention (defined as requiring operative intervention by a trauma surgeon within one hour of arrival to the ED or performance of cricothyroidotomy or thoracotomy in the ED) was confirmed using standardized abstraction. Sensitivities, specificities, and 95% confidence intervals (CIs) were calculated. Results 8,078 patients were included and 47 (0.6%) required emergent intervention. Of the 47 patients, the median age was 11 years (IQR: 7–14), 70% were male, 30% had penetrating mechanisms, and the median ISS was 25 (IQR: 9–41). At the two institutions, the Loma Linda Rule had a sensitivity and specificity of 69% (95% CI: 45%–94%) and 76% (95% CI: 69%–83%), respectively, and the MRC had a sensitivity and specificity of 80% (95% CI: 70%–92%) and 81% (95% CI: 77%–85%), respectively. Conclusions Emergent surgical intervention is rare in the pediatric trauma population. Although precision of predictive accuracies of the Loma Linda Rule and MRC were limited by small numbers of outcomes, neither set of criteria appears to be sufficiently accurate to recommend their routine use. PMID:23623222

Hester Prynne and Linda Lovelace: Pure or Prurient.

ERIC Educational Resources Information Center

Berger, Gertrude

A June 21, 1973, Supreme Court ruling yielded jurisdiction in matters of obscenity to individual communities and the decision as to what is prurient to"contemporary community standards." This ruling leaves the courts in the powerful position of surgeon, judge, film critic, and arbiter of community taste. An analysis of past court cases…

People with disabilities are facing increased hostility.

PubMed

Moon, Cath

2012-02-22

Community learning disability nurse Linda Phillips is to be commended for a comprehensive literature review on improving care for people with learning disabilities in hospital ( art&science February 8 ).

Citrus leprosis virus C Infection Results in Hypersensitive-Like Response, Suppression of the JA/ET Plant Defense Pathway and Promotion of the Colonization of Its Mite Vector

PubMed Central

Arena, Gabriella D.; Ramos-González, Pedro L.; Nunes, Maria A.; Ribeiro-Alves, Marcelo; Camargo, Luis E. A.; Kitajima, Elliot W.; Machado, Marcos A.; Freitas-Astúa, Juliana

2016-01-01

Leprosis is a serious disease of citrus caused by Citrus leprosis virus C (CiLV-C, genus Cilevirus) whose transmission is mediated by false spider mites of the genus Brevipalpus. CiLV-C infection does not systemically spread in any of its known host plants, thus remaining restricted to local lesions around the feeding sites of viruliferous mites. To get insight into this unusual pathosystem, we evaluated the expression profiles of genes involved in defense mechanisms of Arabidopsis thaliana and Citrus sinensis upon infestation with non-viruliferous and viruliferous mites by using reverse-transcription qPCR. These results were analyzed together with the production of reactive oxygen species (ROS) and the appearance of dead cells as assessed by histochemical assays. After interaction with non-viruliferous mites, plants locally accumulated ROS and triggered the salicylic acid (SA) and jasmonate/ethylene (JA/ET) pathways. ERF branch of the JA/ET pathways was highly activated. In contrast, JA pathway genes were markedly suppressed upon the CiLV-C infection mediated by viruliferous mites. Viral infection also intensified the ROS burst and cell death, and enhanced the expression of genes involved in the RNA silencing mechanism and SA pathway. After 13 days of infestation of two sets of Arabidopsis plants with non-viruliferous and viruliferous mites, the number of mites in the CiLV-C infected Arabidopsis plants was significantly higher than in those infested with the non-viruliferous ones. Oviposition of the viruliferous mites occurred preferentially in the CiLV-C infected leaves. Based on these results, we postulated the first model of plant/Brevipalpus mite/cilevirus interaction in which cells surrounding the feeding sites of viruliferous mites typify the outcome of a hypersensitive-like response, whereas viral infection induces changes in the behavior of its vector. PMID:27933078

78 FR 24747 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-26

..., Missouri; David N. Flowers, Greenville, Illinois; Duane Flowers, Trustee of the Linda Flowers Trust, Greenville, Illinois; John Curtis Flowers Trust dtd 2-17-1998, John Curtis Trustee, Greenville, Illinois; J...

Vicarious Collecting: A Review of Some Notable Books about Books - and where to acquire them!

NASA Astrophysics Data System (ADS)

Koester, Jack

Reviews on Milestones of Science, Ruth A. Sparrow, Buffalo Museum of Science, 1972, The Face of the Moon, from the Linda Hall Library, Out of this World - The Golden Age of the Celestial Atlas, Linda Hall Library, including Bayer's Uranometria, Schiller's Coelum Christianum, Hevelius' Firmamentum, Flamsteed's Atlas Coelestis, and Bode's Uranographia, as well as Argelander, Bode, Cellarius, Coronelli, Doppelmaier, Kepler, La Caille, Messier, Piccolomini, and Wollaston, Heavenly Library, Angus MacDonald and A.D. Morrison-Low from Royal Observatory Edinburgh, Library, 1994, Catalogue of the Rare Astronomical Books in the San Diego State University Library, Louis A. Kenney, 1988, and Vanity Fair, from 1869 to 1914, including caricatures of famous astronomers and scientists, such as Airy, Ball, Huggins, and Proctor.

75 FR 65365 - National Institute of Environmental Health Sciences;

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-22

... Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709. Contact Person: Linda K. Bass, PhD... grant applications. Place: Nat. Inst. of Environmental Health Sciences, Building 101, Rodbell Auditorium...

78 FR 106 - National Institute of Neurological Disorders and Stroke, Interagency Pain Research Coordinating...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-02

..., ethnicity, gender, sexual orientation, disability, and cultural, religious, or socioeconomic status. The... due by COB, January 25, 2013, and should be sent to Linda Porter, Ph.D., NINDS/NIH, 31 Center Drive...

Mentoring in Nursing: A Historical Approach.

ERIC Educational Resources Information Center

Fields, Willa L.

1991-01-01

Nursing leaders such as Florence Nightingale, Linda Richards, Mary Adelaide Nutting, and Annie Goodrich were all encouraged by mentors to develop professionally. Most successful professionals have had at least one mentor. (SK)

Buckwheat (Fagopyrum esculentum M.) Sprout Treated with Methyl Jasmonate (MeJA) Improved Anti-Adipogenic Activity Associated with the Oxidative Stress System in 3T3-L1 Adipocytes

PubMed Central

Lee, Young-Jun; Kim, Kui-Jin; Park, Kee-Jai; Yoon, Bo-Ra; Lim, Jeong-Ho; Lee, Ok-Hwan

2013-01-01

Buckwheat sprouts contain various bioactive compounds including rutin which have a number of biological activities. We have previously shown that buckwheat sprouts (TBWE) treated with methyl jasmonate (MeJA) significantly increased the amount of phenolics and the antioxidant activity. The aim of this study was to demonstrate the effect of TBWE on anti-adipogenesis and pro-oxidant enzyme in 3T3-L1 adipocytes. We also evaluated the anti-oxidative activity of TBWE in adipocytes by using the nitroblue tetrazolium assay. Our data showed that TBWE markedly inhibited adipocyte differentiation and ROS production in 3T3-L1 cells compared with control groups. Moreover, TBWE has strongly shown the inhibition of adipogenic transcription factor as well as pro-oxidant enzymes. Together, we demonstrate that the MeJA treatment significantly increased the amount of phenolic compound, resulting in the suppression of adipogenesis and ROS production in the 3T3-L1 cells. These findings indicate that TBWE has the potential for anti-adipogenesis activity with anti-oxidative properties. PMID:23344050

Earthquake and ambient vibration monitoring of the steel-frame UCLA factor building

USGS Publications Warehouse

Kohler, M.D.; Davis, P.M.; Safak, E.

2005-01-01

Dynamic property measurements of the moment-resisting steel-frame University of California, Los Angeles, Factor building are being made to assess how forces are distributed over the building. Fourier amplitude spectra have been calculated from several intervals of ambient vibrations, a 24-hour period of strong winds, and from the 28 March 2003 Encino, California (ML = 2.9), the 3 September 2002 Yorba Linda, California (ML = 4.7), and the 3 November 2002 Central Alaska (Mw = 7.9) earthquakes. Measurements made from the ambient vibration records show that the first-mode frequency of horizontal vibration is between 0.55 and 0.6 Hz. The second horizontal mode has a frequency between 1.6 and 1.9 Hz. In contrast, the first-mode frequencies measured from earthquake data are about 0.05 to 0.1 Hz lower than those corresponding to ambient vibration recordings indicating softening of the soil-structure system as amplitudes become larger. The frequencies revert to pre-earthquake levels within five minutes of the Yorba Linda earthquake. Shaking due to strong winds that occurred during the Encino earthquake dominates the frequency decrease, which correlates in time with the duration of the strong winds. The first shear wave recorded from the Encino and Yorba Linda earthquakes takes about 0.4 sec to travel up the 17-story building. ?? 2005, Earthquake Engineering Research Institute.

76 FR 77283 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-12

... Laurence S. Moy, Pearl Zuchlewski, Linda A. Neilan and Katherine Blostein, The Neutral Corner (Volume 1--2008). In light of the changes set forth in the Dodd-Frank Act that invalidate predispute arbitration...

Employees with Myasthenia Gravis

MedlinePlus

... of Disabilities Publications Resources Home | Accommodation and Compliance Series: Employees with Myasthenia Gravis By Linda Carter Batiste, ... rest breaks Fine Motor Impairment: Implement ergonomic workstation design Provide alternative computer and telephone access Provide arm ...

National Center for Mathematics and Science - publications

Science.gov Websites

Approach to Teaching Evolution Speaks to Debate (press release) Fourth Grade Math Makes the News: VIEW , Megan Loef Franke, Linda Levi Publisher: Heinemann, 2003 Transforming Teaching in Math and Science: How

Chorionic villus sampling

MedlinePlus

... SG, Niebyl JR, Simpson JL, et al, eds. Obstetrics: Normal and Problem Pregnancies. 7th ed. Philadelphia, PA: ... Updated by: John D. Jacobson, MD, Professor of Obstetrics and Gynecology, Loma Linda University School of Medicine, ...

78 FR 40738 - Proposed CERCLA Administrative Cost Recovery Settlement; Double H Pesticide Burial Site

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-08

... are Double H, L.P.; James T. Hansen; Linda L. Hansen; George W. Higgins; and Edith M. Higgins. The... their original terms. Dated: June 27, 2013. Chris D. Field, Manager, Emergency Management Program, U.S...

JPL-082917-CASSINf-0001-Cassini A Saturn Odyssey

NASA Image and Video Library

2017-08-29

A look at the 13-year Cassini-Huygens mission to Saturn and its moon Titan with key moments described by Linda Spilker, Cassini Project Scientist; Earl Maize, Cassini Program Manager; and Julie Webster, Cassini Operations Manager.

Wrist pain

MedlinePlus

... Silver JK, Rizzo TD Jr, eds. Essentials of Physical Medicine and Rehabilitation: Musculoskeletal Disorders, Pain, and Rehabilitation . 3rd ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 36. Review Date 5/14/2017 Updated by: Linda J. ...

Mechanical Properties of Aerojet, Thiokol, and JA2 High-Energy Gun Propellants at 1.5 m/s Deformation Rate

DTIC Science & Technology

2002-01-01

a2 6 n -32 4C La /C A> i c 4S Figure 5. Remains of specimens tested at 210, 630, and -32 0C. 5 I AUg 2001 "-1t AERQJET/"THIDKOL LOTS 0111W PM 4-40.00...10.00 +78.00 STRESS (Mra) -THIOKOL LOT LA -10T3--01 +5.C THIOKOL LOT JA-IEZ35--Z-02 JAZ LOT HCL03JO14-001 -28.00 AE J>:T? +0.00 4.00 0.0 .0 *20.0 O30 +40M0...WARREN MI 48397-5000 MATERIAL SCIENCE TEAM AMSSB RSS 14 BENET LABORATORIES J HERBERT AMSTA AR CCB M SENNETT R FISCELLA KANSAS ST M SOJA NATICK MA 01760

Staff - Linda D. Natrop | Alaska Division of Geological & Geophysical

Science.gov Websites

DGGS library, timesheet processing, state credit card accounting, public information desk, mail and postage, vehicle coordinator, property records, maintain supplies, and other administrative duties as

Sailors' scurvy before and after James Lind--a reassessment.

PubMed

Baron, Jeremy Hugh

2009-06-01

Scurvy is a thousand-year-old stereotypical disease characterized by apathy, weakness, easy bruising with tiny or large skin hemorrhages, friable bleeding gums, and swollen legs. Untreated patients may die. In the last five centuries sailors and some ships' doctors used oranges and lemons to cure and prevent scurvy, yet university-trained European physicians with no experience of either the disease or its cure by citrus fruits persisted in reviews of the extensive but conflicting literature. In the 20(th) century scurvy was shown to be due to a deficiency of the essential food factor ascorbic acid. This vitamin C was synthesized, and in adequate quantities it completely prevents and completely cures the disease, which is now rare. The protagonist of this medical history was James Lind. His report of a prospective controlled therapeutic trial in 1747 preceded by a half-century the British Navy's prevention and cure of scurvy by citrus fruits. After lime-juice was unwittingly substituted for lemon juice in about 1860, the disease returned, especially among sailors on polar explorations. In recent decades revisionist historians have challenged normative accounts, including that of scurvy, and the historicity of Lind's trial. It is therefore timely to reassess systematically the strengths and weaknesses of the canonical saga.

77 FR 66500 - Notice of Final Federal Agency Actions on Proposed Highway in California

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-05

... will be barred unless the claim is filed on or before April 4, 2013. If the Federal law that authorizes... Anaheim and Yorba Linda to Pierce Street in the City of Riverside. The existing express lanes in Orange...

Avation Safety Reporting System (ASRS) 40th Anniversary.

NASA Image and Video Library

2016-09-28

Avation Safety Reporting System (ASRS) 40th Anniversary lunch and open house at the Sunnyvale office. Linda J. Connell, ASRS Program Director (left); Dr. John Lauber, Resident Scientist and early pioneer of the ASRS at Ames, 1972-1985 (Right).

Narrowing the Gap between Research and Practice. Special Edition.

ERIC Educational Resources Information Center

Wilson, Richard, Ed.

1989-01-01

This monograph summarizes recent research on the education of learning disabled students. After an introduction by the editor, individual articles include: "Teaching Listening Skills" (Linda Higbee Mandlebaum and Richard Wilson); "Study-Skills Instruction for Students with Learning Disabilities" (Deborah Gartland);…

MAINTAINING DATA QUALITY IN THE PERFORMANCE OF A LARGE SCALE INTEGRATED MONITORING EFFORT

EPA Science Inventory

Macauley, John M. and Linda C. Harwell. In press. Maintaining Data Quality in the Performance of a Large Scale Integrated Monitoring Effort (Abstract). To be presented at EMAP Symposium 2004: Integrated Monitoring and Assessment for Effective Water Quality Management, 3-7 May 200...

In-Forming Practice through Action Research. Family and Consumer Sciences Teacher Education. Yearbook.

ERIC Educational Resources Information Center

Peterat, Linda, Ed.; Smith, M. Gale

This book contains 16 papers about informing family and consumer sciences educational practice through action research. The following papers are included: "Informing Practice through Classroom Inquiry" (Linda Peterat, M. Gale Smith); "Focusing Praxis Research on Sexism in a Primary Classroom" (Emily Sutherland);…

Pityriasis rosea

MedlinePlus

... Pityriasis rosea. In: Lebwohl MG, Heymann WR, Berth-Jones J, Coulson I, eds. Treatment of Skin Disease: Comprehensive Therapeutic Strategies . 4th ed. Philadelphia, PA: Elsevier; 2014:chap 186. Review Date 12/10/2016 Updated by: Linda J. Vorvick, MD, Clinical Associate ...

MS Godwin works on stowage transfer during STS-108's visit

NASA Image and Video Library

2001-12-05

ISS003-307-032 (5-17 December 2001) --- Astronaut Linda M. Godwin, STS-108 mission specialist, is photographed on the mid deck of the Space Shuttle Endeavour during the transfer of supplies and equipment between the shuttle and the International Space Station (ISS).

78 FR 25755 - Announcement of Funding Awards; Energy Innovation Fund-Multifamily Pilot Program Fiscal Year 2010

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-02

... Awards; Energy Innovation Fund-- Multifamily Pilot Program Fiscal Year 2010 AGENCY: Office of the... funding under the Notice of Funding Availability (NOFA) for the Energy Innovation Fund--Multifamily Pilot.... FOR FURTHER INFORMATION CONTACT: Linda W. Field, Director of Portfolio Management, Office of...

76 FR 81932 - Auction of FM Broadcast Construction Permits; Revised Construction Permit Number in Auction 93

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-29

... Construction Permits; Revised Construction Permit Number in Auction 93 AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: This document announces a change to the construction permit number for one of the FM broadcast construction permits for Auction 93. FOR FURTHER INFORMATION CONTACT: Linda...

Energy Conservation: Three Projects That Worked.

ERIC Educational Resources Information Center

American School and University, 1981

1981-01-01

Compact design and insulation cut energy use at a junior high school in Rexon (New Brunswick). Loma Linda University in California has reduced consumption of natural gas by installing cogeneration equipment. Morningside College in Sioux City (Iowa) has replaced deteriorating windows. (Author/MLF)

76 FR 46308 - National Institute of Environmental Health Sciences; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-02

... Environmental Health Sciences; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... clearly unwarranted invasion of personal privacy. Name of Committee: Environmental Health Sciences Review... Person: Linda K Bass, PhD, Scientific Review Administrator, Scientific Review Branch, Division of...

78 FR 39739 - National Institute of Environmental Health Sciences; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-02

... Environmental Health Sciences; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... clearly unwarranted invasion of personal privacy. Name of Committee: Environmental Health Sciences Review...: Linda K Bass, Ph.D., Scientific Review Officer, Scientific Review Branch, Division of Extramural...

76 FR 62080 - National Institute of Environmental Health Sciences; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-06

... Environmental Health Sciences; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... clearly unwarranted invasion of personal privacy. Name of Committee: Environmental Health Sciences Review... Person: Linda K Bass, PhD, Scientific Review Administrator, Scientific Review Branch, Division of...

75 FR 63532 - Lancaster & Chester Railroad, LLC-Acquisition and Operation Exemption-Line of Lancaster & Chester...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-15

..., Gulf & Ohio Railways Holding Co., Inc., H. Peter Claussen and Linda C. Claussen--Continuance in Control... 20423-0001. In addition, a copy of each pleading must be served on Troy W. Garris, 2904 Corporate Cir....gov . Decided: October 7, 2010. [[Page 63533

"Making Better Colleges": AAC's Century of Change and Commitment

ERIC Educational Resources Information Center

Eisenmann, Linda

2015-01-01

In this article, Linda Eisenman reviews the history of the "Association of American Colleges" (AAC), whose 150 college executives gathered in Chicago in 1915 to create the Association, and chose "inclusiveness" and "interhelpfulness" as twin themes to animate their organization. "Inclusiveness" allowed many…

Condensed-Phase Processes during Solid Propellant Combustion. Part 2: Chemical and Microscopic Examination of Conductively Quenched Samples of RDX, XM39, JA2, M30, and HMX-Binder Compositions

DTIC Science & Technology

1992-05-01

combustion of most of the propellants, with the possible exception of JA2; scanning electron microcope examination shows the existence of a liquid layer but... compounds are similar (Fifer et Sl. 1985; Hoffsommer, Glover, and Elban 1985), the relative Intensities In Table 2 should provide rough, order-of...top of the liquid layer. In addition, the HPLC chromatograms contained a number of very weak, unknown peaks apparently corresponding to compounds

Red Blood Cell Volume, Plasma Volume and Total Blood Volume in Healthy Elderly Men and Women Aged 64 to 100

DTIC Science & Technology

1992-05-06

Robert Valeri, Linda E. Pivacek, Hiliary Siebens, and Mark D. Altschule ». PERFORMING ORGANIZATION NAME AND AOORESS Naval Blood Research Laboratory...Gibson JG, Peacock WC, Seligman AM, Sack T: Circulating red cell volume measured simultaneously by the radioactive iron and dye methods. J Clin

Gigabit Nectar: Architecture and Performance.

DTIC Science & Technology

1995-09-01

proposed American National Standard for Information Systems, 1992. [3] Jose Arabe, Adam Beguelin, Bruce Lowekamp, Eric Seligman , Mike Starkey, and Peter...Shekhar Borkar, Robert Cohn, George Cox, Sha Gleason, Thomas Gross, H. T. Kung, Monica Lam, Brian Moore, Craig Peterson, John Pieper, Linda Rankin, P

Apparent Herbivory and Indigenous Pathogens of Invasive Flowering Rush (Butomus umbellatus L.) in the Pacific Northwest

DTIC Science & Technology

2015-06-01

Boutwell 1990; Rice and Dupuis 2009) and may increase the occurrence of swimmer’s itch (cercarial dermatitis ) by increasing suitable habitat for pond...leadership of Dr. Linda Nelson. POINTS OF CONTACT : For additional information, contact the authors, Nathan Harms (601-634- 2976, Nathan.E.Harms

Predicting Database Requirements for Geographic Information Systems in the Year 2000: Long-Term Design Issues for GRASS

DTIC Science & Technology

1992-08-01

Image Processing. Reading, Massachusetts: Addison-Wesley (1977). Graefe, G., "Parallelizing the Volcano Query Processor," Proc. IEEE COMPCON 90...Approach to a Next Generation of Hypermedia System," Proc. IEEE COMPCON 90 (February 1990), pp 520-527. Jellinghaus, R., " Eiffel Linda: An Object

Math and Science Education. IDRA Focus.

ERIC Educational Resources Information Center

IDRA Newsletter, 1996

1996-01-01

This newsletter focuses on efforts to make math and science more attractive, relevant, and accessible to students, especially limited-English-proficient, minority, economically disadvantaged, female, and at-risk students. "TAAS Math Performance" (Linda Cantu) outlines recent statewide results for the controversial Texas Assessment of…

AOP Knowledge Base/Wiki Tool Set

EPA Science Inventory

Utilizing ToxCast Data and Lifestage Physiologically-Based Pharmacokinetic (PBPK) models to Drive Adverse Outcome Pathways (AOPs)-Based Margin of Exposures (ABME) to Chemicals. Hisham A. El-Masri1, Nicole C. Klienstreur2, Linda Adams1, Tamara Tal1, Stephanie Padilla1, Kristin Is...

Forging Connections in Adult Higher Education. National Conference on Alternative and External Degree Programs for Adults (14th, San Francisco, California, October 6-8, 1994).

ERIC Educational Resources Information Center

American Council on Education, Washington, DC.

This document contains the following 25 papers from a conference on adult higher educational practices: "Learning and Workplace Linkages via Applied Research Projects" (Elaine Cahalan Hollensbe, Linda Hauber); "Practical Action Research in Non-Traditional Students' Senior Projects" (Elliott Lauderdale); "Obtaining the Elusive: An Innovative Degree…

Enhancing Diversity in Agricultural Education.

ERIC Educational Resources Information Center

Bowen, Blannie E., Ed.

This booklet on enhancing diversity in agricultural education consists of six papers. In section 1, the paper, "Embedded Biases in Agricultural Education" (Linda Whent), identifies unconscious biases of agricultural teacher educators toward students of diverse populations, actions that reduce minority student participation in agricultural…

75 FR 51486 - Comment Request for Information Collection for OMB 1205-0030, Job Corps Enrollee Allotment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-20

..., Job Corps Enrollee Allotment Determination, Extension Without Revisions AGENCY: Employment and..., 2010. ADDRESSES: Submit written comments to Linda Estep, Office of Job Corps, Room N4507 Employment and... INFORMATION: I. Background Job Corps is an intensive, residential training program for at-risk youth age 16...

SEEING THE LIGHT: A WATER CLARITY INDEX FOR INTEGRATED WATER QUALITY ASSESSMENTS

EPA Science Inventory

Smith, Lisa M. and Linda C. Harwell. In press. Seeing the Light: A Water Clarity Index for Integrated Water Quality Assessments (Abstract). To be presented at EMAP Symposium 2004: Integrated Monitoring & Assessment for Effective Water Quality Management. 1 p. (ERL,GB R970).
<...

Adventures in Assessment: Learner-Centered Approaches to Assessment and Evaluation in Adult Literacy, 2002.

ERIC Educational Resources Information Center

Cora, Marie, Ed.

2002-01-01

This journal presents the following articles: "Introduction: Volume 14--Examining Performance" (Marie Cora) "Fair Assessment Practices: Giving Students Equitable Opportunities to Demonstrate Learning" (Linda Suskie); "Assessing Oral Communication at the Community Learning Center Development of the OPT (Oral Proficiency Test)" (JoAnne Hartel and…

Modern African, Asian, Latin American, and Middle Eastern Military History: A Bibliography of English-Language Books and Articles Published From 1960-2013

DTIC Science & Technology

2014-03-01

Nutrition , Sanitation, Hygiene, and the Likelihood of Death: The British Army in India c. 1870-1920.” Population Studies XLVII 3 (November 1993...77    Reed, Nelson. The Caste War of Yucatan . Stanford: Stanford University Press, 1964. Rodriguez, Linda Alexander, ed. Rank and Privilege

Florida Journal of Communication Disorders, 2000.

ERIC Educational Resources Information Center

Rosa-Lugo, Linda I., Ed.

2000-01-01

This volume of the Florida Journal of Communication Disorders contains the following featured articles: (1) Using Descriptive Language Assessment Procedure with African-American English Preschool Child Speakers: Advantages and Limitations (Kenyatta O. Rivers and Linda J. Lombardino), which discusses best practices for using descriptive language…

Merging the U.S. Army and the U.S. Marine Corps: Another Crazy Idea or An Inevitable Fact?

DTIC Science & Technology

2004-01-01

looks good on paper, major cultural differences could undermine the merger. In their book “ Managing Organizational Change ,” Connor, Lake, and...Patrick E., Linda K. Lake, and Richard W. Stackman. Managing Organizational Change . 3rd ed. West port, CT.: Praeger Publishers, 2003. Davies

78 FR 13358 - National Institute of Environmental Health Sciences Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

... Environmental Health Sciences Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory... Health Sciences Special Emphasis Panel Research Careers in Environmental Health. Date: March 19, 2013... Conference Call). Contact Person: Linda K Bass, Scientific Review Officer, Scientific Review Branch, Division...

Utilizing ToxCast Data and Lifestage Physiologically-Based Pharmacokinetic (PBPK) models to Drive Adverse Outcome Pathways (AOPs)-Based Margin of Exposures (ABME) to Chemicals.

EPA Science Inventory

Utilizing ToxCast Data and Lifestage Physiologically-Based Pharmacokinetic (PBPK) models to Drive Adverse Outcome Pathways (AOPs)-Based Margin of Exposures (ABME) to Chemicals. Hisham A. El-Masri1, Nicole C. Klienstreur2, Linda Adams1, Tamara Tal1, Stephanie Padilla1, Kristin I...

Teaching "Music" in the Flat World: Reflections on the Work of Darling-Hammond and Rothman

ERIC Educational Resources Information Center

Vaughan-Marra, Jessica C.; Marra, Christopher M.

2017-01-01

Authors and scholars published within "Arts Education Policy Review" have been diligent to investigate various topics surrounding music educator preparation, mentoring, retention, as well as avenues for continued professional development and growth. Linda Darling-Hammond and Robert Rothman, along with various chapter authors, address…

Gifted and Talented Students. IDRA Focus.

ERIC Educational Resources Information Center

IDRA Newsletter, 1998

1998-01-01

This theme issue includes five articles that focus on issues surrounding gifted and talented students, especially as they relate to poor, minority, or limited-English-proficient children. "Traditional Methods of Identifying Gifted Students Overlooks Many" (Linda Cantu) presents findings from the National Educational Longitudinal Study…

RACE AND UNEQUAL EXPOSURE TO POLYCHLORINATED COMPOUNDS - THE ROLE OF DIET

EPA Science Inventory

Max Weintraub, MS, Toxics Office, US Environmental Protection Agency, 75 Hawthorne Street, Mail Code CMD-4, San Francisco, CA 94105 and Linda S. Birnbaum, PhD, Experimental Toxicology Division, NHEERL, US EPA, 66 USEPA Mailroom, Research Triangle Park, NC 27711
The Centers for...

Extending MAM5 Meta-Model and JaCalIV E Framework to Integrate Smart Devices from Real Environments

PubMed Central

2016-01-01

This paper presents the extension of a meta-model (MAM5) and a framework based on the model (JaCalIVE) for developing intelligent virtual environments. The goal of this extension is to develop augmented mirror worlds that represent a real and virtual world coupled, so that the virtual world not only reflects the real one, but also complements it. A new component called a smart resource artifact, that enables modelling and developing devices to access the real physical world, and a human in the loop agent to place a human in the system have been included in the meta-model and framework. The proposed extension of MAM5 has been tested by simulating a light control system where agents can access both virtual and real sensor/actuators through the smart resources developed. The results show that the use of real environment interactive elements (smart resource artifacts) in agent-based simulations allows to minimize the error between simulated and real system. PMID:26926691

Extending MAM5 Meta-Model and JaCalIV E Framework to Integrate Smart Devices from Real Environments.

PubMed

Rincon, J A; Poza-Lujan, Jose-Luis; Julian, V; Posadas-Yagüe, Juan-Luis; Carrascosa, C

2016-01-01

This paper presents the extension of a meta-model (MAM5) and a framework based on the model (JaCalIVE) for developing intelligent virtual environments. The goal of this extension is to develop augmented mirror worlds that represent a real and virtual world coupled, so that the virtual world not only reflects the real one, but also complements it. A new component called a smart resource artifact, that enables modelling and developing devices to access the real physical world, and a human in the loop agent to place a human in the system have been included in the meta-model and framework. The proposed extension of MAM5 has been tested by simulating a light control system where agents can access both virtual and real sensor/actuators through the smart resources developed. The results show that the use of real environment interactive elements (smart resource artifacts) in agent-based simulations allows to minimize the error between simulated and real system.

Counseling the Gifted and Talented.

ERIC Educational Resources Information Center

Silverman, Linda Kreger, Ed.

This graduate-level textbook provides a framework for understanding giftedness, and considers the counseling process and strategies for counseling in the schools. Chapters include: "The Gifted Individual" (Linda Kreger Silverman); "The Quest for Meaning: Counseling Issues with Gifted Children and Adolescents" (Deirdre V. Lovecky); "A Developmental…

Remote Evaluation of the Coherence of Indirect Manipulation Interface Systems For Agent-Mediated Legacy Data

DTIC Science & Technology

2000-05-21

High School Chemistry teacher, for my first thorough appreciation and fine immersion in the scientific method. Mrs. Linda Giffin, Eleventh-Grade...Scott Renner, and Len Seligman . 1997. A consumer viewpoint on `mediator languages -- a proposal for a standard`. SIGMOD Record 26, no. 1: 45-46. http

Database Translator (DATALATOR) for Integrated Exploitation

DTIC Science & Technology

2010-10-31

Modelling in Information Systems Engineering. 2007, Berlin : Springer, pp. 39-58. 2. Arnon Rosenthal, Len Seligman . Pragmatics and Open Problems for Inter...2004, Vol. 2938 . 21. Ahuja, S., N. Carriero and D. Gelemte,. Linda and friends. IEEE Computer. August 1986, pp. 26- 32. 40 Next Generation Software

Selecting, Evaluating and Creating Policies for Computer-Based Resources in the Behavioral Sciences and Education.

ERIC Educational Resources Information Center

Richardson, Linda B., Comp.; And Others

This collection includes four handouts: (1) "Selection Critria Considerations for Computer-Based Resources" (Linda B. Richardson); (2) "Software Collection Policies in Academic Libraries" (a 24-item bibliography, Jane W. Johnson); (3) "Circulation and Security of Software" (a 19-item bibliography, Sara Elizabeth Williams); and (4) "Bibliography of…

76 FR 27653 - National Institute of Environmental Health Sciences; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-12

... Southpoint, 7007 Fayetteville Road, Durham, NC 27713. Contact Person: Linda K. Bass, PhD, Scientific Review... Estimation--Health Risks from Environmental Exposures; 93.142, NIEHS Hazardous Waste Worker Health and Safety Training; 93.143, NIEHS Superfund Hazardous Substances--Basic Research and Education; 93.894, Resources and...

Authors in the Fast Lane!

ERIC Educational Resources Information Center

Follos, Alison M. G.; Rubin, Ellen

2009-01-01

This article introduces various writers, including Laurie Halse Anderson, Linda Sue Park, Richard Peck, James Patterson, and Charles R. Smith, Jr., who will give their presentations at the 2009 American Association of School Librarians (AASL) National Conference & Exhibition in Charlotte. This November the AASL National Conference and…

76 FR 7907 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-11

... EISENBIEGLER PRATIWI ADININGRUM ELSEN MARIA ANTOINETTE FACON DOMINIQUE B. FAIRMAN GARY L FARRAR CHIHO FERDON... ELIZABETH U FUNG PASCALE N GIBSON MATTHEW CHARLES GIBSON SARAH CLAIRE GIDRON GILLA MEZZAN GINDIN DMITRY... LINDA ANETTE HANSEN PAUL ROBERT HARDWICK III CHARLES CHEEVER HARRIS JANE VELDA HARSONO SUDARGO HARTLEY...

STUDIES ON THE METABOLISM OF 6-NITROCHRYSENE AND THE FORMATION OF DNA ADDUCTS IN THE LIVER, LUNG AND BLADDER OF A/J MICE

EPA Science Inventory

/
Studies On The Metabolism of 6-Nitrochrysene and The Formation of DNA Adducts in the Liver, Lung and Bladder ofAJJ Mice
Moses McDaniel*, Linda Adamst, Joycelyn Allisont, Michael George"l", Dhimant Desai+, 5hantu Amin+, Guy Lambertt, William Padgettt, Stephen Nesnowt and...

Global Education Reform: How Privatization and Public Investment Influence Education Outcomes

ERIC Educational Resources Information Center

Adamson, Frank, Ed.; Astrand, Bjorn, Ed.; Darling-Hammond, Linda, Ed.

2016-01-01

With contributions from Linda Darling-Hammond, Michael Fullan, Pasi Sahlberg, and Martin Carnoy, "Global Education Reform" is an eye-opening analysis of national educational reforms and the types of high-achieving systems needed to serve all students equitably.The collection documents the ideologically and educationally distinctive…

A Brighter Future: Solutions to Policy Issues Affecting America's Children.

ERIC Educational Resources Information Center

McQuillan, Lawrence J., Ed.

This collection of papers explains why deep reforms are necessary if today's children are to reach their full potential as productive, independent, and responsible adults. The papers are: (1) "Orphanages as Villages" (Richard B. McKenzie); (2) "Medicating Children" (Linda Gorman); (3) "Government Drug Pushers and the…

77 FR 36012 - Notice of Availability of Funds and Solicitation for Grant Applications for Pay for Success Pilot...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-15

... Workforce Innovation Fund in the Department of Labor Appropriations Act, 2012 (Pub. L. 112-74, Div. F, Tit. I). The Workforce Innovation Fund supports innovative approaches to the design and delivery of... December 11, 2012. FOR FURTHER INFORMATION CONTACT: Linda Forman, Grants Management Specialist, Office of...

Novel Pestivirus Species in Pigs, Austria, 2015.

PubMed

Lamp, Benjamin; Schwarz, Lukas; Högler, Sandra; Riedel, Christiane; Sinn, Leonie; Rebel-Bauder, Barbara; Weissenböck, Herbert; Ladinig, Andrea; Rümenapf, Till

2017-07-01

A novel pestivirus species was discovered in a piglet-producing farm in Austria during virologic examinations of congenital tremor cases. The emergence of this novel pestivirus species, provisionally termed Linda virus, in domestic pigs may have implications for classical swine fever virus surveillance and porcine health management.

Gifted Education Quarterly, 1998.

ERIC Educational Resources Information Center

Fisher, Maurice, Ed.

1998-01-01

These four issues of "Gifted Education Quarterly" include the following articles: (1) "Using Test Results To Support Clinical Judgment" (Linda Kreger Silverman), which discusses some of the difficulties in obtaining accurate indications of a child's level of giftedness and the importance of using professional judgment in…

75 FR 38124 - Final Notice of Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-01

... Web site at http://www.reginfo.gov/public/do/PRAMain or by contacting Linda Watts Thomas on 202-693..., including whether the information will have practical utility; (2) Evaluate the accuracy of the agency's... Burden: $0. Description: This information collection covers complaints of labor standards violations...

Beyond the Wild Blue Yonder: Creating an Air and Space Culture in Today’s Air Force

DTIC Science & Technology

1998-04-01

Organizational Change . 2nd ed. Westport, C.T.: Praeger Publishers, 1994. Estes III, Gen Howell M. “Air Force at a Crossroad” Speech, Air Force...American Military Styles in Strategy and Analysis. Baltimore: Johns Hopkins University Press, 1989. Conner, Patrick E., and Linda K. Lake. Managing

Assessment Update: Progress, Trends, and Practices in Higher Education. Volume 25, Issue 2, March-April 2013

ERIC Educational Resources Information Center

Banta, Trudy W., Ed.

2013-01-01

This issue of "Assessment Update" presents the following articles: (1) "Just Right" Outcomes Assessment: A Fable for Higher Education (Catherine M. Wehlburg); (2) Editor's Notes: Helping Faculty Members Learn (Linda Suskie); (3) Focus on the Bottom-Line: Assessing Business Writing (Michael Cherry and George Klemic); (4)…

Travel in Time: Tradition to Technology. Proceedings of the 1985 ABC International Convention (Chicago, Illinois, October 1985).

ERIC Educational Resources Information Center

Bruno, Sam J., Ed.; Pettit, John D., Jr., Ed.

These conference proceedings contain the following 23 presentations: "Development of a Communication Skill Model Using Interpretive Structural Modeling" (Karen S. Nantz and Linda Gammill); "The Coincidence of Needs: An Inventional Model for Audience Analysis" (Gina Burchard); "A Computer Algorithm for Measuring Readability" (Terry D. Lundgren);…

Avation Safety Reporting System (ASRS) 40th Anniversary.

NASA Image and Video Library

2016-09-28

Avation Safety Reporting System (ASRS) 40th Anniversary lunch and open house at the Sunnyvale office. Linda J. Connell, ASRS Program Director (Left); Thomas A Edwards, Deputy Center Director NASA Ames; Dr. John Lauber, Resident Scientist and pioneer of the ASRS at Ames from 1972-1985 (Right).

Putting the Medical Library Online: Electronic Bulletin Boards. . . and Beyond.

ERIC Educational Resources Information Center

Kittle, Paul W.

1985-01-01

Describes use of microcomputers with system called "TBBS" ("The Bread Board System") at Loma Linda University Medical Center to allow users enhanced services from home, whether library facilities are open or not. Flexibility and security, dialing into medical library, and suggestions for setting up similar computerized…

Building Bridges to Tomorrow in Business and Marketing Education. Atlantic Coast Business and Marketing Education Conference Proceedings (15th, Raleigh, North Carolina, February 20-21, 1998).

ERIC Educational Resources Information Center

Swope, John A., Ed.

This proceedings includes the following papers: "Using Multimedia in Computer Applications" (Delores Barnhill); "Becoming an International Educator: Why, How, and What" (Ray D. Bernardi); "Online Courses--A Bridge for Education" (Phyllis J. Broughton); "Web Page Maintenance" (Linda Carr, Mary Cauley); "Teaching Suggestions to Help Students Prevent…

Nutrition Knowledge among Navy Recruits

DTIC Science & Technology

1987-03-27

Nutrition Knovledge among Navy Recruits DTIC AELEOI7E flS SEP 2 8 1987 Terry L. Conway Linda K. Hervig D Ross R. Vickers, Jr. Health Psychology Department...5 Participants ............................................................. 5 Nutrition Knowledge Questionnaire...Students ............................... 6 Recruits’ Nutrition Knowledge .................................... ...... 8 Correlates of Nutrition Knowledge

Why Henry Giroux's Democratic Pedagogy Is Crucial for Confronting Failed Corporate School Reform and How Liberals Like Ravitch and Darling-Hammond Are Making Things Worse

ERIC Educational Resources Information Center

Saltman, Kenneth J.

2012-01-01

Progressive media and the academic community outside of education has largely embraced liberal criticisms of corporate school reform or neoliberal educational restructuring, typified by the highly publicized writing and speaking of Diane Ravitch and Linda Darling-Hammond. Despite offering valuable policy information, the liberal view is grounded…

Literacy across the CurriculuMedia Focus, 2000.

ERIC Educational Resources Information Center

Shohet, Linda, Ed.

2000-01-01

This volume presents articles and information to support and improve literacy practices in schools, the community, and the workplace. Selected article titles are as follows: "Reaching Learners Where They Are" (Linda Shohet); "The Learners' Wall: Experiences in the Health Care System"; "In-Sites: A Study in Workforce…

Proton Radiation Therapy in the Hospital Environment: Conception, Development, and Operation of the Initial Hospital-Based Facility

NASA Astrophysics Data System (ADS)

Slater, James M.; Slater, Jerry D.; Wroe, Andrew J.

The world's first hospital-based proton treatment center opened at Loma Linda University Medical Center in 1990, following two decades of development. Patients' needs were the driving force behind its conception, development, and execution; the primary needs were delivery of effective conformal doses of ionizing radiation and avoidance of normal tissue to the maximum extent possible. The facility includes a proton synchrotron and delivery system developed in collaboration with physicists and engineers at Fermi National Accelerator Laboratory and from other high-energy-physics laboratories worldwide. The system, operated and maintained by Loma Linda personnel, was designed to be safe, reliable, flexible in utilization, efficient in use, and upgradeable to meet demands of changing patient needs and advances in technology. Since the facility opened, nearly 14,000 adults and children have been treated for a wide range of cancers and other diseases. Ongoing research is expanding the applications of proton therapy, while reducing costs.

78 FR 70237 - Operation of Wireless Communications Services in the 2.3 GHz Band; Establishment of Rules and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-25

... Docket No. 90-357; RM- 8610; FCC 12-130] Operation of Wireless Communications Services in the 2.3 GHz... Amendment of part 27 of its rules to Govern the Operation of Wireless Communications Services in the 2.3 GHz... FURTHER INFORMATION CONTACT: Linda Chang, Federal Communications Commission, Wireless Telecommunications...

CHEMICAL AND TOXICOLOGICAL EVALUATION OF CHLORINATED AND OZONATED-CHLORINATED DRINKING WATER: A COLLABORATION OF THE FOUR NATIONAL LABS OF THE U. S. EPA

EPA Science Inventory

CHEMICAL AND TOXICOLOGICAL EVALUATION OF CHLORINATED AND OZONATED-CHLORINATED DRINKING WATER: A COLLABORATION OF THE FOUR NATIONAL LABS OF THE U.S. EPA
Susan D. Richardson1, Linda K. Teuschler2, Alfred D. Thruston, Jr.,1 Thomas Speth3, Richard J. Miltner3, Glenn Rice2, Kathle...

Citizenship for All in the Literate Community: An Ethnography of Young Children with Significant Disabilities in Inclusive Early Childhood Settings

ERIC Educational Resources Information Center

Kliewer, Christopher; Fitzgerald, Linda May; Meyer-Mork, Jodi; Hartman, Patresa; English-Sand, Pat; Raschke, Donna

2004-01-01

In this study, Christopher Kliewer, Linda Fitzgerald, Jodi Meyer-Mork, Patresa Hartman, Pat English-Sand, and Donna Raschke use ethnographic methods to explore literacy development in young children considered to have significant disabilities. The study settings included nine preschool and kindergarten classrooms across five programs, all of which…

Buyer Beware: Lessons Learned from EdTPA Implementation in New York State

ERIC Educational Resources Information Center

Greenblatt, Deborah; O'Hara, Kate E.

2015-01-01

As states across the country continue their implementation of the Teacher Performance Assessment Portfolio (edTPA), a complex and high-stakes certification requirement for teacher certification, there are important lessons for educators and education advocates to learn from New York State's implementation. As Linda Darling-Hammond, developer and…

78 FR 76598 - Membership of the Performance Review Board

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-18

..., LARRY G. KIM, ROBERT KOEPPEL, DENNIS LABRECK, JANET L. LAKIN, KENNETH CHARLES LHAMON, CATHERINE E. LIM..., SEAN P. CANELLOS, ERNEST C. CARR, PEGGY G. CARTER, DENISE L. CHAVEZ, ANTHONY S. CHISM, MONIQUE M..., LIBIA S. GOMEZ, GABRIELLA GONIPROW, ALEXANDER GRAHAM, DARRELL W. GREWAL, SATYAMDEEP S. HALL, LINDA W...

On Your Mark, Get Set, Wait! Are Your Teacher Candidates Prepared to Embed Assistive Technology in Teaching and Learning?

ERIC Educational Resources Information Center

Nelson, Betty

2006-01-01

Linda Darling-Hammond's simplistic, yet profound observation addresses the basis of reform in teacher education today. Our challenge is to develop the knowledge, disposition, and teaching performance or skills of initial and advanced teacher candidates to enable them to deliver the foundations of education necessary to meet the critical…

Congressional Hearings « Coast Guard Maritime Commons

Science.gov Websites

- Implementation of programs Rear Adm. Linda Fagan, deputy commandant for operations, policy, and capabilities testimony regarding El Faro reports Rear Admiral John Nadeau, assistant commandant for prevention policy final action memo Rear Admiral John Nadeau, assistant commandant for prevention policy, will testify

The Constructivist Leader.

ERIC Educational Resources Information Center

Lambert, Linda; And Others

This book introduces the concept of leadership as the facilitation of constructivist reciprocal processes among participants in an educational community. Chapter 1, "Learning and Leading Theory: A Century in the Making," (Deborah Walker and Linda Lambert) traces the dynamic history of learning and leading during this century, concluding…

Off White: Readings on Race, Power, and Society.

ERIC Educational Resources Information Center

Fine, Michelle, Ed.; Weis, Lois, Ed.; Powell, Linda C., Ed.; Wong, L. Mun, Ed.

The contributions in this volume analyze the white racialization process in the context of multiculturalism and examine how racism is established in institutional structures. The chapters are: (1) "The Achievement (K)not: Whiteness and 'Black Underachievement'" (Linda C. Powell); (2) "White Experimenters, White Blood, and Other White Conditions:…

Adult Learning: A Key for the 21st Century. CONFINTEA V Background Papers (Hamburg, Germany, July 14-18, 1997).

ERIC Educational Resources Information Center

Adult Education and Development, 1997

1997-01-01

The following papers are included: "Foreword" (Jakob Horn, Paul Belanger); "Internationalization and Globalization" (Ove Korsgaard); "Adult Learning and the Challenges of the 21st Century" (Marc-Laurent Hazoume); "Diversity in Adult Education: Some Key Concepts in Minority and Indigenous Issues" (Linda King de Jardon); "The Culture of Peace: The…

Reading, Language Arts & Literacy. [SITE 2001 Section].

ERIC Educational Resources Information Center

Matthew, Kathy, Ed.

This document contains the following papers on reading, language arts, and literacy from the SITE (Society for Information Technology & Teacher Education) 2001 conference: (1) "Improving the Teaching of Reading, Language Arts and Literacy through WebCT: A Work in Progress" (Linda Akanbi); (2) "A Survey of Computer Software…

Celebrating Excellence: Learning and Teaching in Adult Higher Education. National Conference on Alternative and External Degree Programs for Adults (15th, Columbus, Ohio, October 5-7, 1995).

ERIC Educational Resources Information Center

Alliance, an Association for Alternative Degree Programs.

These 23 presentations are organized in five categories: diversity, assessment, distance education, learning, and teaching. Five papers on diversity include the following: "From Rosie the Riveter to Comparable Worth: The Infusion of Gender and Women's Issues into an Interdisciplinary Curriculum for Working Adults" (Linda L. Hulbert, Theodore A.…

Technology for Education. IDRA Focus.

ERIC Educational Resources Information Center

IDRA Newsletter, 1998

1998-01-01

This theme issue includes five articles that focus on technology for education to benefit all students, including limited-English-proficient, minority, economically disadvantaged, and at-risk students. "Coca-Cola Valued Youth Program Students Meet Peers Via Video Conference" (Linda Cantu, Leticia Lopez-De La Garza) describes how at-risk…

Politics, the Media, and the Right to Know.

ERIC Educational Resources Information Center

Berry, John; And Others

1992-01-01

Report on the 1992 American Library Association (ALA) conference discusses featured speakers, political actions of the ALA Council, guidelines on patron behavior, the resignation of ALA Executive Director Linda Crismond, and conference exhibits. Excerpts from an address by new ALA president Marilyn Miller on empowering people through libraries are…

Proceedings of the EMU Conference on Foreign Languages for Business and the Professions (Dearborn, Michigan, April 5-7, 1984). Part VIII: Spanish for Business and the Professions.

ERIC Educational Resources Information Center

Voght, Geoffrey M., Ed.

Part VIII of the proceedings includes 16 presentations. They are: "Strengthening Internationalism through the Establishment of a Center for Spanish Language Training for Engineering Students" (David C. Kraft, Pamela J. Madl, Robert C. Spires, and Rusty McClanahan); "Training Court Interpreters: A Practitioner's Perspective" (Linda E. Haughton);…

Emotions Targeting Moral Exemplarity: Making Sense of the Logical Geography of Admiration, Emulation and Elevation

ERIC Educational Resources Information Center

Kristjánsson, Kristján

2017-01-01

Despite renewed interest in moral role-modelling and its emotional underpinnings, further conceptual work is needed on the logical geography of the emotions purportedly driving it, in particular, admiration, emulation and elevation. In this article, I explore admiration (as understood by Linda Zagzebski), emulation (as understood by Aristotle) and…

The Positive Impact of Early Intervention for Children with Developmental Delays, Gestational Cocaine Exposure, and Co-Occurring Risk Factors

ERIC Educational Resources Information Center

Ullery, Mary Anne; Katz, Lynne

2017-01-01

This article examined transition rates of young children (n = 102) from an early intervention program at the Linda Ray Intervention Program (LRIP) who had documented developmental delays and co-occurring prenatal drug exposure often coupled with verified child maltreatment. Findings indicated that there was significant group improvement from…

Reflecting Visions. New Perspectives on Adult Education for Indigenous Peoples.

ERIC Educational Resources Information Center

King, Linda, Ed.

This book contains 14 papers: "Indigenous Peoples and Adult Education: A Growing Challenge" (Rodolfo Stavenhagen); "Indigenous Peoples: Progress in the International Recognition of Human Rights and the Role of Education" (Julian Burger); "Adult Learning in the Context of Indigenous Societies" (Linda King); "Linguistic Rights and the Role of…

The Inside-Out Approach

ERIC Educational Resources Information Center

Lindsey, Delores B.; MacDonell, Linda

2011-01-01

Linda MacDonell is the assistant superintendent of the Instructional Services Division of the Orange County (California) Department of Education and over the years, Delores Lindsey served as MacDonell's leadership coach. In this article, they talk about their experiences as external/internal partners building internal capacity for culturally…

A Collection of Papers on Self-Study and Institutional Improvement, 2003. Volume 1: Establishing and Sustaining Effective Connections. 2003 Edition.

ERIC Educational Resources Information Center

Van Kollenburg, Susan E., Ed.

Papers in this collection were prepared for the annual meeting of the North Central Association of Colleges and Schools. This volume contains papers discussing establishing and sustaining effective connections. Chapter 1, "Building New Partnerships for Learning," contains: (1) "Developing the ABCs of Successful Partnerships" (Linda L. Baer and Ann…

Collaborative Learning in Higher Education. Proceedings of the Teaching Conference (Bloomington, Indiana, October 11-12, 1990). Panel Discussions and Selected Presentations.

ERIC Educational Resources Information Center

Hansen, Edmund, Ed.; And Others

This conference report contains selected presentations and panel discussions concerning the experiences of faculty and students with learner-oriented approaches to college teaching. Following a welcome address by Kenneth R. R. Gross-Louis and keynote addresses by Faith Gabelnick and Linda Harasim, papers are organized in two categories:…

Promoting Evidence-Based Practices: New Teaching Module for Early Childhood Teacher Educators

ERIC Educational Resources Information Center

Young Children, 2009

2009-01-01

Linda Halgunseth, head of NAEYC's Office of Applied Research (OAR), tells readers about Child Care and Early Education Research Connections, a Web site (www.researchconnections.org/teaching_modules) to help teacher educators integrate knowledge about evidence-based practices into teacher education programs. In addition, the article touts the…

Monograph: Young Adulthood and Middle Age, 1989.

ERIC Educational Resources Information Center

Monograph: Young Adulthood and Middle Age, 1989

1989-01-01

The inaugural volume of this serial contains 12 articles that represent a diverse population of counselors: (1) "Issues in Counseling Immigrants" (Linda Sheppard); (2) "Family Support and Starting a Small Business" (Michael Cusack and Peter Emerson); (3) "Professional Disillusionment: Crisis or Catalyst" (Kay Miller, Susan Cooper-Shoup and…

Novel Pestivirus Species in Pigs, Austria, 2015

PubMed Central

Schwarz, Lukas; Högler, Sandra; Riedel, Christiane; Sinn, Leonie; Rebel-Bauder, Barbara; Weissenböck, Herbert; Ladinig, Andrea; Rümenapf, Till

2017-01-01

A novel pestivirus species was discovered in a piglet-producing farm in Austria during virologic examinations of congenital tremor cases. The emergence of this novel pestivirus species, provisionally termed Linda virus, in domestic pigs may have implications for classical swine fever virus surveillance and porcine health management. PMID:28628456

Ke Ha'a La Puna i Ka Makani: Pele and Hi'iaka Mo'olelo and the Possibilities for Hawaiian Literary Analysis

ERIC Educational Resources Information Center

ho'omanawanui, ku'ualoha

2013-01-01

In 2003, the University of Hawai'i sponsored a symposium titled "Indigenizing the University." This symposium featured indigenous scholars such as Linda Tuhiwai Smith, Graham Smith, and Taiaiake Alfred, who addressed how indigenous political theory and methods of research were necessary to support indigenous research and how changes…

Mentoring in nursing: a historical approach.

PubMed

Fields, W L

1991-01-01

Most nurses today have or have had mentors. Several historical nurse leaders also had mentors. Florence Nightingale's mentor gave her the opportunity to work as a nurse during the Crimean War. Linda Richards, Mary Adelaide Nutting, and Annie Goodrich were all encouraged by their respective mentors to develop professionally.

Education Policy Analysis Archives, 2000.

ERIC Educational Resources Information Center

Glass, Gene V., Ed.

2000-01-01

This document consists of the 2000 edition of the "Education Policy Analysis Archives." The papers include: (1) "Teacher Quality and Student Achievement: A Review of State Policy Evidence" (Linda Darling-Hammond); (2) "America Y2K: The Obsolescence of Educational Reforms" (Sherman Dorn); (3) "Forces for Change in…

Come to the River: Using Spirituality to Cope, Resist, and Develop Identity

ERIC Educational Resources Information Center

Watt, Sherry K.

2003-01-01

This chapter describes and discusses spiritual lives of African American female college students, including elements of coping, resisting, and developing identity. The theoretical frameworks of James Fowler, Sharon Parks, and Linda James Myers are viewed through the lens of experiences of African American women in college. Qualitative research…

Making Connections, Building Communities. Proceedings of the Annual Rural & Small Schools Conference (19th, Manhattan, Kansas, October 26-27, 1997).

ERIC Educational Resources Information Center

Kansas State Univ., Manhattan. Center for Rural Education and Small Schools.

This proceedings contains 26 summaries of conference presentations and discussions. Titles and authors are: "Is a Sexual Harassment Policy Enough To Protect Against Liability?" (Camille Barnett); "Recreating the Communities of Our Youth" (Marlyn Benson); "Creating a Language of Ethics in Rural Schooling" (Terry R. Berkeley, Linda P. Thurston);…

Redefining Professional Development. Newsletter

ERIC Educational Resources Information Center

Center for Comprehensive School Reform and Improvement, 2006

2006-01-01

The research on effective professional development is consistent across many studies. Researchers Willis Hawley and Linda Valli (Westchester Institute for Human Services Research, n.d.), in their synthesis of the professional development literature, find that high-quality teacher development is as follows: (1) Informed by research on teaching and…

Writing Instruction.

ERIC Educational Resources Information Center

Richgels, Donald J.

2003-01-01

Discusses four recent writing books: "Teaching to Write: Theory Into Practice" (Jane B. Hughey and Charlotte Slack); "The Writing Teacher's Handbook" (Jo Phenix); "Scaffolding Young Writers: A Writers' Workshop Approach" (Linda J. Dorn and Carla Soffos); and "Directing the Writing Workshop: An Elementary Teacher's Handbook" (Jean Wallace Gillet…

Vienna in the Early Twentieth Century: The Cultural Response to Modernization. Curriculum Units, NEH Institute, Summer 1993.

ERIC Educational Resources Information Center

Oregon Univ., Eugene.

These curriculum units were developed by participants in the National Endowment for the Humanities seminar at the University of Oregon in 1993. The lessons include: (1) "Schule, Freunde, Liebe: Wien um die Jahrhundertwende (School, Friends, Love: Vienna at the Turn of the Century)" (Linda Hansen; Glenn Tetterton-Opheim); (2) "Kultur…

SALT (Strategic Arms Limitation Talks): A Selective Bibliography, 1971-1981.

DTIC Science & Technology

1982-08-01

European Security: Mutual and Balance Force Reductions." Linda P. Brady. INTERNATIONAL SECURITY REVIEW 6:189-208, Summer 1981 "Negotiating With The...Danger." D. Seligman . FORTUNE 99:50-56, July 2, 1979 "Participation of the European States in the SALT III Negotiations." Hubertus Hoffmann and Rolf

Career Choice and Development. Third Edition.

ERIC Educational Resources Information Center

Brown, Duane; And Others

This book contains 12 papers examining established and newly emerging theories of career choice and development. Following prefaces to the third, second, and first editions by Duane Brown and Linda Brooks, the following papers are included: "Introduction to Theories of Career Development and Choice: Origins, Evolution, and Current Efforts" (Duane…

Species Profiles: Life Histories and Environmental Requirements of Coastal Fishes and Invertebrates (Mid-Atlantic): Weakfish

DTIC Science & Technology

1989-08-01

Linda P. Mercer North Carolina Division of Marine Fisheries Morehead City, NC 28557 Project Officer David Moran U.S. Fish and Wildlife Service National...of the nomenclature, taxonomy, morphology, distribution, life history, population structure and dynamics, and the fishery of the blue crab...AND RECREATIONAL FISHERIES .. ............. ........ ECOLOGICAL ROLE. .... ................... .......... 9 Food habits

Does Scale Really Matter? Ultra-Large-Scale Systems Seven Years after the Study

DTIC Science & Technology

2013-05-24

Beyonce Knowles releases second consecutive No.1 album and fourth No.1 single in the US BlackBerry users numbered 4,900,000 in March, 2006...And yet…there is a fast growing gap between our research and reality. 75 Does Scale Really Matter?: ULS Systems Seven Years Later Linda Northrop

STS-37 Mission Specialist (MS) Godwin during simulation in JSC's FB-SMS

NASA Technical Reports Server (NTRS)

1991-01-01

STS-37 Mission Specialist (MS) Linda M. Godwin rehearses some phases of her scheduled duties on the middeck of the fixed-based (FB) shuttle mission simulator (SMS) located in JSC's Mission Simulation and Training Facility Bldg 5. Godwin is inspecting supplies stowed in the middeck lockers during this unsuited simulation.

78 FR 15024 - National Institute of Neurological Disorders and Stroke, Interagency Pain Research Coordinating...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-08

..., 31 Center Drive, Room 8A03, Bethesda, MD 20892, or by email to [email protected] . Nominations... CONTACT: Contact Linda Porter, Ph.D., NINDS/ NIH, 31 Center Drive, Room 8A03, Bethesda, MD 20892, porterl... made without discrimination on the basis of age, race, ethnicity, gender, sexual orientation...

International Reports on Literacy Research: Canada, France, Russia

ERIC Educational Resources Information Center

Malloy, Jacquelynn A., Comp.; Botzakis, Stergios, Comp.

2006-01-01

This article is a compilation of reports on international literacy research. The report includes 3 separate reports on Canada, France and Russia. In the first report, research correspondent Linda M. Phillips, in collaboration with Christian Beaulieu, reports on the Canadian Language and Literacy Research Network (CLLRNet). The vision of CLLRNet is…

Toward 21st Century Supports

ERIC Educational Resources Information Center

Umphrey, Jan

2010-01-01

This article presents an interview with Linda Darling-Hammond, Charles Ducommun Professor of Education at Stanford University, director of the Stanford Center for Opportunity Policy and Education, and codirector of the school redesign network at Stanford. In this interview, Darling-Hammond describes the term "21st century skills" and shares her…

NASA Chief Technologist on Panel at Massachusetts Institute of Technology

NASA Image and Video Library

2018-02-15

During MIT's "Better MIT Innovation Week 2018," a group of experts discussed innovation as a critical component to and professional accomplishment. From left: Rebecca Chui, founder, RootsStudio; Reinaldo Normand, entrepreneur in residence, MIT; Douglas Terrier, NASA chief technologist; Linda Foster, chief technologist, Lockheed Martin. (Photo: Damian Barabonkov/MIT Technique)

Questions of Intimacy: Rethinking Population Education.

ERIC Educational Resources Information Center

King, Linda, Ed.

This document contains 14 papers that examine recent changes in the definition, principles, and delivery of population education throughout the world. The paper titles are as follows: "Introduction" (Linda King); "Reaching Men for Health and Development" (Benno de Keijzer); "Boys, Men and Questions of Masculinity in South Africa" (Robert Morrell);…

Economic Education Experiences of Enterprising Teachers. Volume 30.

ERIC Educational Resources Information Center

Nappi, Andrew T., Ed.

This book describes award-winning teacher-developed projects and courses in economics. The reports are condensed versions of the original projects and are divided into grade levels. Primary Level includes: "Peanut Economics" (Janet Lancaster; Dena L. Meade); "Consumer Education Circus" (Pearl Eloshway; Linda McGeehan); "Critter Cards" (Joyce G.…

Multiple Voices for Ethnically Diverse Exceptional Learners, 2000.

ERIC Educational Resources Information Center

Ford, Bridgie Alexis, Ed.

2001-01-01

This publication presents seven articles concerned with the education of students with disabilities or special talents who also have cultural or linguistic differences. Section 1 contains the following four articles: (1) "Code Switching: A Bridge or Barrier between Two Languages?" (Alejandro Brice and Linda I. Rosa-Lugo); (2) "Resistance Theories:…

Intensive Care

ERIC Educational Resources Information Center

Edmunds, Lavinia

2004-01-01

This article describes how two Baltimore teachers, Rachel Rosenblatt and Linda Andersen, provide tutorial work with hospital patients at the Kennedy Krieger Institute. Their work is part of the in-hospital educational aid offered by Baltimore school district to help students recover from serious illnesses or injuries. The Baltimore program, which…

A More Realistic Approach to the Measurement of Occupational Interests in a Service Setting. Part 1. Form EZ.

DTIC Science & Technology

1979-12-01

their engagement who use a specific outside job opportunity in support could have the reality of their plans evaluated by either previously recorded...programme. Factored data on this are now to hand 3 at the suggestion of P. J. Oswnld Nita Cherry, Linda Gatiss, John Urbano and will be discussed in

78 FR 42805 - Nixon Presidential Historical Materials: Opening of Materials

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-17

... Library in Yorba Linda. The newly released tapes will also be available on August 21, 2013 on the Web at... Nixon Presidential Historical Materials by the Richard Nixon Presidential Library and Museum, a division... required by law, including the PRMPA. DATES: The Richard Nixon Presidential Library and Museum intends to...

A Fresh Start for New Orleans' Children: Improving Education after Katrina. Hearing before the Subcommittee on Education and Early Childhood Development of the Committee on Health, Education, Labor, and Pensions, United States Senate. One Hundred Ninth Congress, Second Session on Examining the Education System of New Orleans (July 14, 2006, New Orleans, LA). Senate Hearing 109-626

ERIC Educational Resources Information Center

US Senate, 2007

2007-01-01

The purpose of this hearing was to examine the education system of New Orleans. Statements were presented by: Honorable Lamar Alexander, Chairman, Subcommittee on Education and Early Childhood Development; Honorable Mary L. Landrieu, U.S. Senator from Louisiana; Honorable Richard Burr, U.S. Senator from North Carolina; Linda Johnson, President,…

Undergraduate Student Perspectives on Electronic Portfolio Assessment in College Composition Courses

ERIC Educational Resources Information Center

Fullerton, Bridget Katherine Jean

2017-01-01

Though Linda Adler-Kassner and Peggy O'Neill claim that ethical writing assessment models "must be designed and built collaboratively, with careful attention to the values and passions of all involved, through a process that provides access to all," college students have not typically been included in scholarly conversations about…

Science Learning: Processes and Applications.

ERIC Educational Resources Information Center

Santa, Carol Minnick, Ed.; Alvermann, Donna E., Ed.

Reflecting a collaboration in terms of content areas, levels, and audience, this volume represents the efforts of science teachers and reading teachers to understand and help one another fine tune their craft. Chapters in the volume include: (1) "Metacognition, Reading and Science Education" (Linda Baker); (2) "Science and Reading:…

75 FR 61998 - Programs for Specific Positions and Examinations (Miscellaneous)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-07

...-mail at [email protected] ; or fax at (202) 606-2329. FOR FURTHER INFORMATION CONTACT: Ms. Linda Watson [email protected] . SUPPLEMENTARY INFORMATION: On March 20, 2007, OPM published a final rule at 72 FR 12947..., the potential differences between the ethical requirements that pertain to an advocate and those...

"Response to Comments": Straw Makeovers, Dogmatic Holism, and Interesting Conversation

ERIC Educational Resources Information Center

Howe, Kenneth R.

2009-01-01

This paper presents the author's response to commentaries by Eric Bredo, R. Burke Johnson, and Linda Tillman on his article "Positivist Dogmas, Rhetoric, and the Education Science Question." Each of the commentaries goes beyond merely characterizing and assessing the author's analysis to also suggest an alternative emphasis, if not an alternative…

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (74th, Boston, Massachusetts, August 7-10, 1991). Part VII: Journalism and Media History, Section A.

ERIC Educational Resources Information Center

Association for Education in Journalism and Mass Communication.

Section A of the Journalism and Media History section of the proceedings contains the following 16 papers: "Covering the 'World's Most Famous' Trial: An Examination of the Choices Made by Georgia Reporters" (Gregory C. Lisby and Linda L. Harris); "Market Segmentation and Political Capital as Supports for Newspaper Partisanship: The…

75 FR 62366 - Notice of Public Information Collections Being Reviewed by the U.S. Agency for International...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-08

... mail comments to: Linda Walker, Bureau for Economic Growth, Agriculture and Trade, Office of Education... where foreign nationals must travel to the U.S. to participate in training or invitational travel, the... traveling to the U.S.; second, to enable USAID to be in compliance with external requirements of the...

Leadership Development. IDRA Focus.

ERIC Educational Resources Information Center

IDRA Newsletter, 1997

1997-01-01

This newsletter includes three articles on the theme of leadership development, particularly in relation to high-risk students or Mexican American communities. "Coca-Cola Valued Youth Program: 'Because All Children Are Valuable'" (Linda Cantu) shares some success stories from the program, which recruits high-risk students to be tutors of…

A Matter of Degrees: Preparing Teachers for the Pre-K Classroom. Education Reform Series

ERIC Educational Resources Information Center

Bueno, Marisa; Darling-Hammond, Linda; Gonzales, Danielle

2010-01-01

Research indicates that state pre-k programs with higher teacher qualification requirements improve children's school readiness so states get the most out of their investment in early education. This 2010 report, authored by Marisa Bueno, Linda Darling-Hammond and Danielle Gonzales, reviewed research on training for pre-k teachers and concluded…

Role of HRD in Women's Career Development. Symposium 17. [AHRD Conference, 2001].

ERIC Educational Resources Information Center

2001

This symposium on the role of human resource development (HRD) in women's career development consists of three presentations. "Career Goals of Non-Managerial Women: An Adaptive Approach" (Linda M. Hite, Kimberly S. McDonald) reports an exploratory study that produced data from which these four themes emerged--adaptive goals, family…

Translation of Evidence-Based Practices in a Behaviour Support Implementation Model for Youth with Autism Spectrum Disorders

ERIC Educational Resources Information Center

Lyons, Gregory

2011-01-01

Linda Miller describes a model for the practical implementation of behaviour supports. This model, the "5P approach", attempts to delineate a comprehensive and sequentially-stepped model of the assessment and treatment of challenging behaviour with consistent colour-coded themes. The 5Ps include profiling the child, prioritising the challenging…

Networking the Light Fantastic--CD-ROMs on LANs.

ERIC Educational Resources Information Center

Kittle, Paul W.

1992-01-01

Describes the development of a local area network (LAN) at Loma Linda University that allows remote access for both IBM and Macintosh microcomputers to CD-ROMs. Topics discussed include types of networks; fiber optic technology; networking CD-ROM drives; remote access; modems; CD-ROM databases; memory management; interface software; and future…

Bridges, 1999.

ERIC Educational Resources Information Center

Wilcox, Bonita; Manear, John; Slifkin, Josh M.

This volume contains articles about writing, best practice, portfolio assessment, and technology, as well as original poetry and book reviews. Articles in the volume are: "Teaching Writing: Making Connections" (Eric Schott); "Empowering Teachers: A Success Story" (Sandra L. Krivak); "Bridging the Gap between the Classroom and Employment" (Linda C.…

Seed germination ecology of feather lovegrass [Eragrostis tenella (L.) Beauv. Ex Roemer & J.A. Schultes].

PubMed

Chauhan, Bhagirath S

2013-01-01

Feather lovegrass [Eragrostis tenella (L.) Beauv. Ex Roemer & J.A. Schultes] is a C4 grass weed that has the ability to grow in both lowland and upland conditions. Experiments were conducted in the laboratory and screenhouse to evaluate the effect of environmental factors on germination, emergence, and growth of this weed species. Germination in the light/dark regime was higher at alternating day/night temperatures of 30/20 °C (98%) than at 35/25 °C (83%) or 25/15 °C (62%). Germination was completely inhibited by darkness. The osmotic potential and sodium chloride concentrations required for 50% inhibition of maximum germination were -0.7 MPa and 76 mM, respectively. The highest seedling emergence (69%) was observed from the seeds sown on the soil surface and no seedlings emerged from seeds buried at depths of 0.5 cm or more. The use of residue as mulches significantly reduced the emergence and biomass of feather lovegrass seedlings. A residue amount of 0.5 t ha(-1) was needed to suppress 50% of the maximum seedlings. Because germination was strongly stimulated by light and seedling emergence was the highest for the seeds sown on the soil surface, feather lovegrass is likely to become a problematic weed in zero-till systems. The knowledge gained from this study could help in developing effective and sustainable weed management strategies.

The JaCVAM international validation study on the in vivo comet assay: Selection of test chemicals.

PubMed

Morita, Takeshi; Uno, Yoshifumi; Honma, Masamitsu; Kojima, Hajime; Hayashi, Makoto; Tice, Raymond R; Corvi, Raffaella; Schechtman, Leonard

2015-07-01

The Japanese Center for the Validation of Alternative Methods (JaCVAM) sponsored an international prevalidation and validation study of the in vivo rat alkaline pH comet assay. The main objective of the study was to assess the sensitivity and specificity of the assay for correctly identifying genotoxic carcinogens, as compared with the traditional rat liver unscheduled DNA synthesis assay. Based on existing carcinogenicity and genotoxicity data and chemical class information, 90 chemicals were identified as primary candidates for use in the validation study. From these 90 chemicals, 46 secondary candidates and then 40 final chemicals were selected based on a sufficiency of carcinogenic and genotoxic data, differences in chemical class or genotoxic or carcinogenic mode of action (MOA), availability, price, and ease of handling. These 40 chemicals included 19 genotoxic carcinogens, 6 genotoxic non-carcinogens, 7 non-genotoxic carcinogens and 8 non-genotoxic non-carcinogens. "Genotoxicity" was defined as positive in the Ames mutagenicity test or in one of the standard in vivo genotoxicity tests (primarily the erythrocyte micronucleus assay). These chemicals covered various chemicals classes, MOAs, and genotoxicity profiles and were considered to be suitable for the purpose of the validation study. General principles of chemical selection for validation studies are discussed. Copyright © 2015 Elsevier B.V. All rights reserved.

"Like Melody or Witchcraft": Empowerment through Literature

ERIC Educational Resources Information Center

Miranda, Deborah A.

2004-01-01

This document, written by a Native American woman, examines the authors' personal feelings of writing about being a child of color in a white world. The author hopes to evoke a resonance within her readers through her writing. She discusses quotes from two of her favorite poets, Emily Dickinson and Linda Hogan.

75 FR 69061 - Senior Executive Service; Performance Review Board

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-10

..., Linda C Burrows, Charles W Buttress, Larry D Buzzard, Christine M Cadieux, Gena E Callahan, Samuel N... Bekkedahl, Larry N Bell, Melody C Berkowitz, Barry E Bieniawski, Andrew J Bishop, Clarence T Bishop, Tracey..., Douglas E Kane, Michael C Kaplan, Stan M Kearney, James H Kelly, Henry C Kelly, Larry C Kenchington, Henry...

A Disability Studies Response to JTE's Themed Issue on Diversity and Disability in Teacher Education

ERIC Educational Resources Information Center

Collins, Kathleen M.

2013-01-01

In a recent themed issue of "Journal of Teacher Education" ("JTE" 63.4) about issues of disability, diversity, and teacher education, guest editors Marleen Pugach, Linda Blanton, and Lani Florian (2012) invite readers to participate in "honest, difficult, and much needed dialogue across the many diversity constituencies in teacher education" (p.…

The Problematics of Postmodernism: The Double-Voiced Honors Canon.

ERIC Educational Resources Information Center

McCracken, Tim

Honors education is not immune from the current controversy concerning the role of the literary canon. Indeed, the problem seems especially crucial for honors programs, for their curriculums are often multi-disciplinary in their approaches to culture and history. The solution may lie in what Linda Hutcheon calls the "poetics of the…

Women in the 80’s; A Selective Bibliography, 1980-1984 in Observance of National Women’s History Week, 4-10 March 1984.

DTIC Science & Technology

1984-03-01

OF BLACK WOMEN TO AMERICA. Columbia, SC: Kenday Press, 1982. 2 vols. E185.86 .C585 1982 De Pauw, Linda Grant. SEAFARING WOMEN. Boston, MA: Houghton...a Tough Fight Ahead." J.M. Von Seldeneck. MANAGEMENT WORLD 11:1+, November 1982 "Truth in Discrimination." (Unisex insurance) D. Seligman . FORTUNE

Species Profiles: Life Histories and Environmental Requirements of Coastal Fishes and Invertebrates (South Atlantic). Black Sea Bass

DTIC Science & Technology

1989-07-01

Environmental Requirements of Coastal Fishes and Invertebrates (South Atlantic) BLACK SEA BASS BY Linda P. Mercer North Carolina Division of Marine Fisheries ...CHARACTERISTICS. .. ....... ....... ...... ..... 6 FISHERY .. .. ....... ...... ....... ....... ..... 7 Commnercial Harvest...Manooch, III, Gene Huntsman, and R.O. Parker, Jr., of the National Marine Fisheries Service, Beaufort Laboratory, and C. Wayne Waltz of the South

We May Well Become Accomplices: To Rear a Generation of Spectators Is Not to Educate at All

ERIC Educational Resources Information Center

King, Joyce E.

2016-01-01

Research on education and society is the focus in discussing four essays of AERA past presidents, Newton Edwards, Maxine Greene, Linda Darling-Hammond, and William F. Tate, IV. The title, "We May Well Become Accomplices... ," is taken from Greene's speech to foreground inherent moral obligations of scholars when racial and social justice…

Adult Learning and Literacy in Canada

ERIC Educational Resources Information Center

Shohet, Linda

2001-01-01

In Chapter Six, Linda Shohet offers a description of the adult literacy and learning system in Canada. In providing a historical overview of the development of the field, Shohet notes key political events that have influenced the funding and development of services for adults. Through her description, the author reveals the complexity and…

Gender-Based Violence Prevention. Issues in Prevention

ERIC Educational Resources Information Center

Higher Education Center for Alcohol, Drug Abuse, and Violence Prevention, 2012

2012-01-01

This issue of "Issues in Prevention" focuses on gender-based violence prevention. This issue contains the following articles: (1) Preventing Gender-Based Violence: An Overview (Linda Langford); (2) Q&A With Amelia Cobb; (3) Denim Day at HBCUs; (4) Dear Colleague Letter; (5) ED Grants for Violence Prevention; and (6) Higher Education Center…

Oscar F. Smith Middle School: One Extra Degree

ERIC Educational Resources Information Center

Principal Leadership, 2012

2012-01-01

This article features Oscar F. Smith Middle School, a challenging school in Chesapeake, Virginia. When Principal Linda Scott exclaims, "Oscar F. Smith Middle School is "hot"!" to visitors, she is not referring to the inside temperature of the bustling school of grades 6-8 located in the historic South Norfolk borough of…

Social Security: The Notch Issue.

DTIC Science & Technology

1988-03-24

the Exact Match Study, see Beth Kilss, Fritz Scheuren, Fay Aziz, and Linda DelBane, "The 1973 CPS-IRS-SSA Exact Match Study: Past, Present and Future...34 inPolicy Analysis with Social Security Research Files, Proceedings, SSA, 1978. 2For more discussion of the project, see Haber (1985) and, in the

"Affection in Education": Edward Carpenter, John Addington Symonds and the Politics of Greek Love

ERIC Educational Resources Information Center

Quinn, Josephine Crawley; Brooke, Christopher

2011-01-01

The paper examines Edward Carpenter's 1899 essay on education that defended the value of powerful same-sex attachments, either between older and younger boys or between teachers and pupils, in the context of Victorian ideologies of same-sex affection. Linda Dowling has described how "a homosexual counterdiscourse able to justify male love in…

CYP1A2 DOES NOT PLAY A CRITICAL ROLE IN 2, 3 7, 8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED IMMUNOSUPRESSION

EPA Science Inventory

CYP1A2 IS NOT REQUIRED FOR 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED IMMUNOSUPPRESSION Smialowicz, Ralph J1; Burgin, Deborah E2; Williams, Wanda C1; Diliberto, Janet J1; Birnbaum, Linda S1
1 Experimental Toxicology Division, US EPA, RTP, NC, USA; 2Curriculum in Toxicology, U...

Notes from the Pressure Cooker: Sharpening Our Professional Edge

ERIC Educational Resources Information Center

Osborne, Carol; Piver, Patricia

2011-01-01

Advocates for teacher education reform are calling for university faculty to become more in tune with conditions in the schools. Linda Darling-Hammond (2006), for one, says that "the enterprise of teacher education must venture out further and further from the university and engage ever more closely with schools in a mutual transformation…

Life Affirming Work and Social Justice. Symposium.

ERIC Educational Resources Information Center

2002

This document contains three papers from a symposium on life-affirming work and social justice that was conducted as part of a conference on human resource development (HRD). "Doing Good or Doing Well? A Counter-story of Continuing Professional Education (CPE)" (Laurel Jeris, Linda Armacost) reports on an exploratory study in which a…

What Are We Observing and How?

ERIC Educational Resources Information Center

Davis, Linda

2016-01-01

In this talk, Linda Davis discusses observation at the adolescent level. She explains that we must "adjust our approach for the third plane of development, for when they are becoming adults." Using examples, she discusses the characteristics of this plane, which are helpful to recall when thinking about what to expect when observing…

Thoughts on "Reconsidering the Washington-Du Bois Debate: Two Black Colleges in 1910-1911" and Thoughts on "Liberalism at the Crossroads: Jimmy Carter, Joseph Califano, and Public College Desegregation."

ERIC Educational Resources Information Center

Edwards, Anthony

These two papers offer critiques of two essays that appeared in "Essays in Twentieth-Century Southern Education: Exceptionalism and its Limits," edited by Wayne J. Urban. The first paper examines Linda Buchanan and Philo Hutcheson's interpretation of the debate which underscored the well-known conflict between Booker T. Washington-W.E.B.…

Best Leadership Practices for High-Poverty Schools

ERIC Educational Resources Information Center

Lyman, Linda L.; Villani, Christine J.

2004-01-01

This book presents both the practice and theory of best leadership practices in high-poverty schools. Authors Linda Lyman and Christine Villani take a unique approach by inviting readers into two high-poverty elementary schools where they will experience, through in-depth case studies, how two extraordinary principals model and practice their…

The Not-So-Dirty Dozen: Reflections on a President's Two Lives

ERIC Educational Resources Information Center

Bowman, Linda S.

2017-01-01

Having come into community colleges as an adjunct instructor 25 years ago, Linda Bowman notes that much has changed since then. Demographics are shifting, high school enrollments are declining, state budgets are tightening, and community colleges are grappling with greater competition from public and private/nonprofit, as well as from for-profit…

Higher Education for Women in Postwar America, 1945-1965

ERIC Educational Resources Information Center

Eisenmann, Linda

2006-01-01

This history explores the nature of postwar advocacy for women's higher education, acknowledging its unique relationship to the expectations of the era and recognizing its particular type of adaptive activism. Linda Eisenmann illuminates the impact of this advocacy in the postwar era, identifying a link between women's activism during World War II…

Developing "Argumentation" with the 4-11 Age Range

ERIC Educational Resources Information Center

Russell, Terry; McGuigan, Linda; Hamilton, Janet; Geldard, Joanne

2016-01-01

Terry Russell and Linda McGuigan of the University of Liverpool draw on their classroom research to offer their thoughts on argumentation, an aspect of "working scientifically," with contributions from two recent research collaborators: Janet Hamilton teaching 4-6 year-olds and Joanne Geldard teaching science to 10-11 year-olds. Between…

The Activist WPA in Action: A Profile of the Firstyear Writing Program at Eastern Michigan University

ERIC Educational Resources Information Center

Irvin, L. Lennie

2009-01-01

This writing program profile examines the work of Dr. Linda Adler-Kassner and the ways in which she has redefined writing and the place of first-year writing at her university. The profile highlights Adler-Kassner's development of an "open systems" curriculum and her use of assessment for program visibility and continuous program…

Invited Reaction: Black and White Women Managers--Access to Opportunity

ERIC Educational Resources Information Center

Higginbotham, Elizabeth

2004-01-01

In a survey of Black and White women managers, Linda M. Hite identifies differences in the managers' perceptions of opportunities available to different race and gender groups. Her findings reveal divergent beliefs about the opportunities for people of color; there is more similarity in Black and White women's views when comparing opportunities…

Race Equity in Education: The History of School Desegregation 1849-1979.

ERIC Educational Resources Information Center

Aquila, Frank D., Ed.

This book is a compilation of articles by Linda Zook, Steven Bower, Thomas Black, Frank Aquila, Patrick Tydings, Robert Powers, and Bruce Graham on the legal and educational history of school segregation. An initial article reviews the Federal court process. Also presented is a general historical review of Supreme Court doctrine on the issue of…

Documenting the Diaspora: Historian Couple Investigate Central Africa's Place in World History, Rooting Black Studies in an International Context

ERIC Educational Resources Information Center

Roach, Ronald

2004-01-01

At a time when Black studies programs at American colleges and universities are placing increasing emphasis on the impact of Black migrations and movements throughout the world, scholars such as Drs. John Thornton and Linda Heywood, husband and wife historians, are gaining prominence in the discipline due to the shilling focus. Scholars like this…

76 FR 70711 - Senior Executive Service; Performance Review Board

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-15

... BROWN, FRED L BROWN, STEPHANIE H BRUCE, SANDRA D BRYAN, PAUL F BRYAN, WILLIAM N BURROWS, CHARLES W... GEERNAERT, GERALD L GEISER, DAVID W GELLES, CHRISTINE M GENDRON, MARK O GERRARD, JOHN E GIBBS, ROBERT C... HOLLETT, DOUGLAS W HOLLRITH, JAMES W HORTON, LINDA L HOWARD, MICHAEL F HOWELL JR, J T HUIZENGA, DAVID G...

Healing Systemic Fragmentation in Education through Multicultural Education

ERIC Educational Resources Information Center

Saathoff, Stacy D.

2017-01-01

The dismissal of students' backgrounds by the educational system has a deep effect on communities of color, perpetuating a system that sets them up for academic failure. Maori scholar Linda Tuhiwai Smith (2012) created terminology for the process of systematic fragmentation, which she describes as an act of dismissal on a macro-level. This article…

Chronic Pain Following Spinal Cord Injury: The Role of Immunogenetics and Time of Injury Pain Treatment

DTIC Science & Technology

2017-12-01

for the expression of spontaneous activity in damaged sensory axons of mice. The Journal of Physiology 550, 921-926 3. Milligan, E.D. & Linda Watkins ...http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus &list_uids=19833175 8. Watkins , L.R., Hutchinson, M.R., Rice, K.C

Effects of the Administration's Fiscal Year 1984 Budget on Children and Youth. Hearing before the Task Force on Entitlements, Uncontrollables, and Indexing of the Committee on the Budget. House of Representatives, Ninety-Eighth Congress, First Session (March 9, 1983). Serial No. TF8-4.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Committee on the Budget.

In this report of a hearing on the effects on children and youth of President Reagan's proposed budget cuts of means-tested entitlement programs, Linda S. McMahon, Associate Commissioner of the Office of Family Assistance, and Robert E. Leard, Acting Administrator of the Food and Nutrition Service at the Department of Agriculture, present the…

75 FR 81998 - Notice of Performance Review Board Membership

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-29

..., Thomas N. Mr. Leikach, Kalmen I. Mr. Lewis, David H. RDML Ligler, Frances S. Dr. Maguire, Margaret M. Ms... McManamon, James P. RDML McNair, John W. Mr. Meadows, Linda J. Ms. Mitchell, Stephen E. Mr. Montgomery, John..., Office of Civilian Human Resources, telephone 202-685-6341. Dated: December 22, 2010. H.E. Higgins...

Accountability Is More than a Test Score

ERIC Educational Resources Information Center

Turnipseed, Stephan; Darling-Hammond, Linda

2015-01-01

The number one quality business leaders look for in employees is creativity and yet the U.S. education system undermines the development of the higher-order skills that promote creativity by its dogged focus on multiple-choice tests. Stephan Turnipseed and Linda DarlingHammond discuss the kind of rich accountability system that will help students…

Hawaii Literacy Hui Conference, 1997: Changing Lives, Building Communities. [Videotape].

ERIC Educational Resources Information Center

Darling-Hammond, Linda; Holt, Linda

This videotape presents the keynote speeches of the 1997 Hawai'i Literacy Hui conference on the theme of "Changing Lives, Building Communities." Featured in the videotape are two speeches: Linda Darling-Hammond's "The Right To Learn and Teach: Towards Democratic Education," in which she discusses how authentic assessment in the context of the new…

Where Focus on the Family Falls Short on Character Development.

ERIC Educational Resources Information Center

Berman, Sheldon H.

1995-01-01

Linda Page's article ("A Conservative Christian View on Values," this issue) mistakenly argues that the source of this country's moral crisis lies in a 30-year history of moral relativism in schools promoted by the values-clarification movement. Page unfairly blames educators for the growth in crime and violence and the decline of moral…

They're a Hard Act to Follow: Four Professors Who Make Them Laugh in Liberal Arts.

ERIC Educational Resources Information Center

Blue, Thomas R.; And Others

Four teachers at Fort Lewis College, Colorado, use humor to send messages which "leap frog" resistance to the new and different, and go directly to the preconscious. The power in these humorous conceptual leaps is that the entering information sticks to the anger and passions of the human psyche, thus fostering retention. Linda Mack, a…

Teaching for Joy and Justice: Re-Imagining the Language Arts Classroom

ERIC Educational Resources Information Center

Christensen, Linda

2009-01-01

"Teaching for Joy and Justice" is the much-anticipated sequel to Linda Christensen's bestselling, "Reading, Writing, and Rising Up." Christensen is recognized as one of the country's finest teachers. Her latest book shows why. Through story upon story, Christensen demonstrates how she draws on students' lives and the world to teach poetry, essay,…

Making Strides

ERIC Educational Resources Information Center

Roach, Ronald

2008-01-01

Since 1980, Dr. Linda Hayden has been able to bring innovation to Elizabeth City State University (ECSU) by seeking out and partnering with entities like the U.S. Navy and NASA. For years, these partnerships allowed faculty, students, and administrators in the computer science department and other departments to gain early exposure to cutting-edge…

Brown Plus Thirty: Perspectives on Desegregation. Proceedings of a Conference Commemorating the Thirtieth Anniversary of the 1954 Supreme Court Decision in Brown v. The Board of Education of Topeka, Kansas (New York, New York, September 11-14, 1984).

ERIC Educational Resources Information Center

Miller, Lamar P., Ed.

This report comprises papers delivered at a conference assessing the impact of the Supreme Court decision in the case of Brown v. Board of Education 30 years after it was passed in 1954. The following papers (and authors) are included: (1) "Reflections on Brown after Thirty Years" (Linda Brown Smith); (2) "School Integration and the…

Waging Peace in Our Schools: Beginning with the Children. Peace Education Miniprints No. 80.

ERIC Educational Resources Information Center

Lantieri, Linda

The Resolving Conflict Creatively Program (RCCP) began in New York City by Linda Lantieri who is now the national director. This program is for teachers, students, administrators, and parents who seek to make schools and society more peaceful through creative means. RCCP was developed because of the increasing statistics of violent acts that take…

STS-37 crewmembers watch Pilot Cameron juggle cassettes on OV-104's middeck

NASA Technical Reports Server (NTRS)

1991-01-01

STS-37 crewmembers watch Pilot Kenneth D. Cameron juggle cassette tapes on the middeck of Atlantis, Orbiter Vehicle (OV) 104. Laughing at Cameron's stunt are Mission Specialist (MS) Linda M. Godwin (foreground), Commander Steven R. Nagel (behind Cameron), and MS Jerry L. Ross (at floor level). Ross snacks on chocolate candy during the performance.

Unintended Consequences of A-76 and Downsizing of the Military

DTIC Science & Technology

2002-12-01

AIR WAR COLLEGE AIR UNIVERSITY UNINTENDED CONSEQUENCES OF A-76 AND DOWNSIZING OF THE MILITARY by Linda M. Thomas, Lt Col, USAF A Research...REPORT DATE DEC 2002 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Unintended Consequences of A-76 and Downsizing of the...of A-76. ...................................................................................15 UNINTENDED CONSEQUENCES

Gender Tracing and Literacy Narratives.

ERIC Educational Resources Information Center

Kuhne, Michael

A good way "to get at gender" is to ask students to write about their literacy because literacy is a good catalyst for discussion and analysis regarding the complexities of gender. A number of recent articles connect composition studies with issues of gender, including those by Elizabeth Flynn, Geoff Sirc, Linda Peterson, Don Kraemer…

Who Says There Have Been Great Women Artists? Some Afterthoughts

ERIC Educational Resources Information Center

Clark, Roger; Folgo, Ashley

2006-01-01

Last year these authors addressed an issue in these pages that echoed Linda Nochlin 's (1971) haunting question, "Why have there been no great women artists?" (Clark, Folgo, & Pichette, 2005). That essay examined the question, "Have there now been any great women artists?" through a study of art history textbooks primarily written for college…

Risky Business: Taking and Managing Risks in Library Services for Teens

ERIC Educational Resources Information Center

Braun, Linda W.; Martin, Hillias J.; Urquhart, Connie

2010-01-01

Do we add that edgy urban novel to our teen collection? Should we initiate social networking? What about abandoning Dewey for a bookstore arrangement? Change is risky business, but librarians must be prepared to initiate change to best serve teens. YA (young adult) service innovators Linda W. Braun, Hillias J. Martin, and Connie Urquhart explain…

Investigation of plasma behavior during noble gas injection in the end-cell of GAMMA 10/PDX by using the multi-fluid code ‘LINDA’

NASA Astrophysics Data System (ADS)

Islam, M. S.; Nakashima, Y.; Hatayama, A.

2017-12-01

The linear divertor analysis with fluid model (LINDA) code has been developed in order to simulate plasma behavior in the end-cell of linear fusion device GAMMA 10/PDX. This paper presents the basic structure and simulated results of the LINDA code. The atomic processes of hydrogen and impurities have been included in the present model in order to investigate energy loss processes and mechanism of plasma detachment. A comparison among Ar, Kr and Xe shows that Xe is the most effective gas on the reduction of electron and ion temperature. Xe injection leads to strong reduction in the temperature of electron and ion. The energy loss terms for both the electron and the ion are enhanced significantly during Xe injection. It is shown that the major energy loss channels for ion and electron are charge-exchange loss and radiative power loss of the radiator gas, respectively. These outcomes indicate that Xe injection in the plasma edge region is effective for reducing plasma energy and generating detached plasma in linear device GAMMA 10/PDX.

Interoperability, Data Control and Battlespace Visualization using XML, XSLT and X3D

DTIC Science & Technology

2003-09-01

26 Rosenthal, Arnon, Seligman , Len and Costello, Roger, XML, Databases, and Interoperability, Federal Database Colloquium, AFCEA, San Diego...79 Rosenthal, Arnon, Seligman , Len and Costello, Roger, “XML, Databases, and Interoperability”, Federal Database Colloquium, AFCEA, San Diego, 1999... Linda , Mastering XML, Premium Edition, SYBEX, 2001 Wooldridge, Michael , An Introduction to MultiAgent Systems, Wiley, 2002 PAPERS Abernathy, M

Construction Sites: Excavating Race, Class, and Gender among Urban Youth. The Teaching for Social Justice Series.

ERIC Educational Resources Information Center

Weis, Lois, Ed.; Fine, Michelle, Ed.

This book presents a collection of papers on the lives of urban youths in and out of school. There are 17 chapters in 4 parts. Part 1, "Spaces for Identity Work," includes: (1) "Writing on the Bias" (Linda Brodkey); (2) "Learning to Speak Out in an Abstinence-Based Sex Education Group: Gender and Race Work in an Urban…

Parallel Evolution in Science: The Historical Roots and Central Concepts of General Systems Theory; and "General Systems Theory,""Modern Organizational Theory," and Organizational Communication.

ERIC Educational Resources Information Center

Lederman, Linda Costigan; Rogers, Don

The two papers in this document focus on general systems theory. In her paper, Linda Lederman discusses the emergence and evolution of general systems theory, defines its central concepts, and draws some conclusions regarding the nature of the theory and its value as an epistemology. Don Rogers, in his paper, relates some of the important features…

Problematizing Assumptions, Examining Dilemmas, and Exploring Promising Possibilities in Culturally Relevant Pedagogy. A Response to "'I Didn't See It as a Cultural Thing': Supervisors of Student Teachers Define and Describe Culturally Responsive Supervision"

ERIC Educational Resources Information Center

Dantas-Whitney, Maria; Ulveland, R. Dana

2016-01-01

In response to the study and recommendations presented in the article "I Didn't See it as a Cultural Thing," written by Linda Griffin, Dyan Watson and Tonda Liggett, we explore three interrelated topics. First, we seek to problematize some of the assumptions in the study. We review some of the authors' approaches and assertions that seem…

Expanding the Vision of Self: Why the Arts Matter

ERIC Educational Resources Information Center

Nathan, Linda F.

2013-01-01

In this reflective essay, Linda F. Nathan, the founding headmaster of the Boston Arts Academy and currently the executive director of Center for Arts in Education at Boston Arts Academy, shares a story about how one student, Ronald, expands his vision of self through his engagement with the arts. In presenting this reflection on Ronald's…

Mitigating the Effects of Poverty and Crime: The Long-Term Effects of an Early Intervention Programme for Children Who Were Developmentally Delayed and Prenatally Exposed to Cocaine

ERIC Educational Resources Information Center

Ullery, Mary Anne; Gonzalez, Antonio; Katz, Lynne

2016-01-01

This study explores the long-term impact on participation in the Linda Ray Intervention Program (LRIP) for children (n = 54) who were developmentally delayed and prenatally exposed to cocaine. By identifying a group of programme graduates from a high crime/high poverty neighbourhood in Miami-Dade County using ArcGIS 10.2 software, a…

Social Studies: Selected Teaching Approaches.

ERIC Educational Resources Information Center

Thomas, John I., Ed.

Nine essays serving as springboards to the study of historical events and cultures focus on the use of memorabilia and primary resources for teaching social studies. Following a short preface by John I. Thomas, Linda Carrillo examines ways in which folk songs can be used to arouse a child's interest in the study of other cultures. In "Using…

Chronic Pain Following Spinal Cord Injury: The Role of Immunogenetics and Time of Injury Pain Treatment

DTIC Science & Technology

2016-10-01

sensory axons of mice. The Journal of Physiology 550, 921-926 3. Milligan, E.D. & Linda Watkins , L.R. (2009) Pathological and protective roles of glia in...pubmed&cmd=Retrieve&dopt=AbstractPlus &list_uids=19833175 8. Watkins , L.R., Hutchinson, M.R., Rice, K.C. & Maier, S.F. (2009) The "toll" of opioid

The Harbour School, A Very Special School. IssueTrak: A CEFPI Brief on Educational Facility Issues

ERIC Educational Resources Information Center

Stenzler, Yale

2005-01-01

The Harbour School in Baltimore County, Maryland and provides a unique and outstanding setting that was designed to enhance and support the programs and services required for 125 special-needs students between the ages of 6 and 21. The director of the school, Dr. Linda Jacobs, had previous experience with establishing a school in a commercial…

The Peep Show

ERIC Educational Resources Information Center

Gamble, David L.

2010-01-01

Three years ago, the author and Linda Arbuckle (University of Florida ceramic professor and internationally known majolica clay artist) were on the phone discussing how electric kilns just don't have any artistic design flair to them. The round kiln has basic properties that allow it to function properly, but its looks are far from exciting. They…

LJ Q&A "ALA Candidates": Library Advocacy x 2

ERIC Educational Resources Information Center

Berry, John N., III

2008-01-01

Library advocacy in one of two directions is the top priority of both Camila Alire and J. Linda Williams, the candidates campaigning to capture the 2009-10 term as president of the American Library Association (ALA). Alire, dean emeritus of the libraries of both the University of New Mexico and Colorado State University, will push for enhancements…

STS-59 crewmembers during WETF bailouts

NASA Image and Video Library

1993-12-02

S93-50711 (22 Dec 1993) --- Astronauts Kevin P. Chilton (right), pilot, and Linda M. Godwin, payload commander, are assisted by SCUBA-equipped divers during emergency bailout training at the Johnson Space Center's (JSC) Weightless Environment Training Facility (WET-F). Godwin, Chilton and four other NASA astronauts are scheduled to fly aboard the Space Shuttle Endeavour next year.

From School-Culture-to-Family-Culture: Reflections on Four Generations of a Deweyan Education in Hawai'i

ERIC Educational Resources Information Center

Makaiau, Amber Strong

2015-01-01

In 1918, the author's great great aunt, Sophie Judd Cooke founded a small progressive school in Honolulu. Her brother Henry named it Hanahau'oli School, which means joyful work school. In this essay the author's mother, Linda Summers Strong and the author reflect on the impact of Hanahau'oli School's Deweyan approach to education on the…

Leadership. Research in Management Series.

ERIC Educational Resources Information Center

Neider, Linda L. Ed.; Schriesheim, Chester A., Ed.

This volume in the Research in Management series is devoted to the field of leadership--a look at where it has been and where it seems to be going. A "Foreword" (Linda L. Neider, Chester A. Schriesheim) is followed by seven chapters highlighting creative, new looks at leadership and adept analyses of leadership theories that have already…

Is Space Big Enough for a US-SINO Partnership

DTIC Science & Technology

2010-04-01

the other, I believe that space is big enough, that there is a future for the US and China in space. I would like to thank Lt Col Rick Rogers, my... Riordan , Jeff Yuen and Cathy Perro; Lt Cols James Quinn, Stan Kekauoha and Linda Cole; and Major Dave Ashley, who continues to push harder and run

Indigenous Art

ERIC Educational Resources Information Center

Hu, Helen

2012-01-01

Linda Lomahaftewa, a noted painter, has taught at much bigger places than the Institute of American Indian Arts (IAIA). But Lomahaftewa, who is Hopi-Choctaw, and others on the faculty of IAIA are intensely devoted to the mission of this small but unique school. IAIA--the nation's only four-year fine arts institution devoted to American Indian and…

Installation Restoration Program, Stage 3, McClellan Air Force Base. Preliminary Groundwater Operable Unit Remedial Investigation (Hydrogeologic Assessment) Sampling and Analysis Plan

DTIC Science & Technology

1990-02-01

PRESENT C,(8;2) 131o sia &1 OTE MUNICIPAL WATER b9PLY WELLS: ON-BASE CW CITY OSARMENTO AREAS NW NORTHRIDGE WATEtj DISTRICT RW RIO LINDA AW ARCADE WATER...1ASE PRODUCTION WELL ACTIVE BAS PRODUCTION WELL ., CITY WELL T #f CALTRANS WELL . EXTRACTION WELL 0 500 1000 N : SCALL IN FEET If-3. 82

Weaving Wisdom with Hard Work: Accomplished Student Learns, Grows, and Gives Back

ERIC Educational Resources Information Center

Kuhl, Eleanor

2010-01-01

Linda Taylor (Dine) raises sheep and horses, creates sculpture, paints, teaches traditional weaving classes, hunts solo for elk and deer, and volunteers at the Methodist Thrift Shop. In the past, she has also cared for Native children in need, and she is currently applying to foster a Navajo girl. On weekends, she sells bales of hay at the…

Our Visions of Possibility for Literacy

ERIC Educational Resources Information Center

O'Keefe, Tim; Reinier, Rise; Gallagher, Kevin; Morgan, Bruce; Lopez-Robertson, Julia; Santman, Donna; Wong-Kam, JoAnn; Hill, Sharon; Christensen, Linda

2006-01-01

Tim O'Keefe, Rise Reinier and Kevin Gallagher, Bruce Morgan, Julia Lopez-Robertson, Donna Santman, JoAnn Wong-Kam, Sharon Hill, and Linda Christensen provide short essays describing their personal visions of possibility about literacy and how they maintain that passion and vision. Across a range of contexts, they reflect on the ways in which their…

Amazing Altered Books

ERIC Educational Resources Information Center

Kieling, Linda W.

2006-01-01

Linda Kieling, an art teacher at Rosemont Ridge Middle school in West Linn, Oregon, describes an altered book art project she introduced to her students. Alteration of books is a form of recycling that started in the eleventh century when Italian monks recycled old manuscripts written on vellum by scraping off the ink and adding new text and…

Writing Is Not Just a Basic Skill

ERIC Educational Resources Information Center

Richardson, Mark

2008-01-01

At many colleges, professors trained in the discipline of rhetoric and composition are finding that the specialized knowledge they bring to teaching writing is held in thrall to older notions of how students learn to write--what Linda Brodkey, an author and director of the Warren College Writing Program at the University of California at San…

Getting Teacher Evaluation Right: What Really Matters for Effectiveness and Improvement

ERIC Educational Resources Information Center

Darling-Hammond, Linda

2013-01-01

Teacher evaluation systems are being overhauled by states and districts across the United States. And, while intentions are admirable, the result for many new systems is that good--often excellent--teachers are lost in the process. In the end, students are the losers. In her new book, Linda Darling-Hammond makes a compelling case for a…

Education Reformer: Robert J. Marzano. Models for Education Reform, Part 1

ERIC Educational Resources Information Center

Dessoff, Alan

2012-01-01

Frederick M. Hess, director of education policy studies at the American Enterprise Institute, a public policy think tank in Washington, D.C., and Linda Darling-Hammond, a professor of education at Stanford University, wrote in "How to Rescue Education Reform" in The New York Times on December 5 that the federal government can and should play a…

Total Warrant Officer System (TWOS). Volume 1

DTIC Science & Technology

1985-08-30

Compensation DiGirolamo, Nicholas A. CW4 OD ARNG Representative Dougherty, John R. CW4 AV Action Officer Hawk, Chuck CW4 AV Branch Chief Jinks, Dennis M. CW4...NCOIC Knight, Lewis D. SSG 81E Illustrator Cunningham, Linda L. SGT 71C Secretary/ Steno Grigsby, Steven A. SP4 64C Driver iv - ---- . "%o EXECUTIVE

"A Lifelong Aversion to Writing": What if Writing Courses Emphasized Motivation?

ERIC Educational Resources Information Center

Sullivan, Patrick

2011-01-01

There has been a great deal of groundbreaking research done on motivation during the last twenty-five years, and all of it points to the importance of intrinsic motivation. This research has very significant ramifications for teachers of English. In this essay, the author engages the issue of "aversion" that Linda Brodkey raises in her essay…

Supporting Moral Development: The Virtues Project[TM

ERIC Educational Resources Information Center

de Moor, Gerrit

2011-01-01

The Virtues Project[TM] was founded in Canada in 1991 by Linda Kavelin Popov, Dan Popov, and John Kavelin who were concerned about the level of violence among families and youth. In studying sacred traditions and cultures around the world, they identified a set of common virtues. These were used to develop a pedagogical model that has applications…

"We Were Those Who Walked out of Bullets and Hunger": Representation of Trauma and Healing in "Solar Storms"

ERIC Educational Resources Information Center

Vernon, Irene S.

2012-01-01

Scholars Kali Tal and Cathy Caruth express the importance of trauma literature as "the need to tell and retell the story of the traumatic experience, to make it "real" both to the victim and to the community," and to tell "a reality or truth that is not otherwise available." In "Solar Storms" Linda Hogan vividly recounts the consequences of…

JPL-20170811-CASSINf-0001a-A World Unveiled Cassini at TItan

NASA Image and Video Library

2017-08-11

A look at the Cassini-Huygens mission's discoveries at Saturn's moon Titan and a description of how flybys of Titan allowed the mission to change to new orbits repeatedly without wasting fuel. Featuring Linda Spilker, Cassini Project Scientist, JPL; Jonathan Lunine, Cassini Titan Scientist, Cornell University; and Elizabeth "Zibi" Turtle, Cassini Imaging Team, John Hopkins Applied Physics Laboratory.

EMPLOYEE SPIRITUAL CARE: Supporting Those Who Care for Others.

PubMed

McMillan, Kathleen

2016-01-01

In order to provide whole-person care for patients and families, Loma Linda University Health recognizes the importance of supporting employee wholeness. The Employee Spiritual Care department helps create and support an environment that nurtures the spiritual health and wholeness of employees, and provides employees tools and knowledge about providing whole-person care to patients and colleagues.

2,3,7, 8-TETRACHLORODIBENZO-P-DIOXIN (TCDD)-MEDIATED OXIDATIVE STRESS IN FEMALE CYP1A-2 KNOCKOUT (CYP1A2-/-) MICE

EPA Science Inventory

2,3,7,8-Tetrachlordibenzo-p-dioxin (TCDD)-Mediated Oxidative Stress in Female CYP1A2 Knockout (CYP1A2-/-) Mice

Deborah Burgin1, Janet Diliberto2, Linda Birnbaum2
1UNC Toxicology; 2USEPA/ORD/NHEERL, RTP, NC

Most of the effects due to TCDD exposure are mediated via...

76 FR 66972 - Linda Sue Cheek, M.D., Decision and Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-28

... only pain management doctor reasonably available in southwestern Virginia,'' ALJ at 34; here again... the hearing. (See ALJ Exs. 3 & 4.) Both parties called witnesses to testify and introduced documentary... practice to include a specialty in pain management and alternative medicine. Since 1998, Respondent has...

Engaging 21st-Century Adolescents: Video Games in the Reading Classroom

ERIC Educational Resources Information Center

Adams, Megan Glover

2009-01-01

Cross-age tutoring, in which older and younger students work together to improve their ELA skills, is not a new concept; Linda D. Labbo and William H. Teale explored it as a tool for poor readers as early as 1990. The author has found that using tutoring with video games also works well. Students have the opportunity to read aloud collaboratively…

Socioeconomic Impact Analysis Study. Disposal and Reuse of Loring Air Force Base, Maine

DTIC Science & Technology

1994-03-01

Regional Airport by approximately 23.2 percent ( Hoyle , Tanner and Associates, Inc., 1993). 3.7.3 Rail Recent Trends Rail service is provided to Loring...1993. Personal communication with Chief Hotelling, Volunteer Fire Department, Town of Stockholm. Hoyle , Tanner & Associates, Inc., 1993. Regional...with Linda Richardson, Administrative Assistant, Aroostook County Government. St. Pierre, F., 1993. Personal communication with Fred St. Pierre, 1st

JPL-20170825-CASSINf-0001-Cassini Nears the End of Its Mission Video File

NASA Image and Video Library

2017-08-25

On Sept. 15, 2017, NASA's Cassini spacecraft will end it mission by diving into the atomosphere of Saturn. Animation: one of Cassini's final passes between Saturn and its rings, Cassini's final 22 orbits, final plunge. Footage: construction of Cassini at JPL. Interview excerpts from Linda Spilker, Cassini Project Scientist; Earl Maize, Cassini Project Manager; Julie Webster, Cassini Spacecraft Operations Manager.

Automated Program Recognition by Graph Parsing

DTIC Science & Technology

1992-07-01

structures (cliches) in a program can help an experienced programmer understand the program. Based on the known relationships between the clichis, a...Graph Parsing Linda Mary Wills Abstract The recognition of standard computational structures (cliches) in a program can help an experienced programmer...3.4.1 Structure -Sharing ....... ............................ 76 3.4.2 Aggregation ....................................... 80 2 3.5 Chart Parsing Flow

Towards Enhancing Written Communication Skills in the Army: Cognitive and Metacognitive Perspective

DTIC Science & Technology

1987-08-01

Din: 2 Technical Report 755 Towards Enhancing Written Communication Skills in the Army: Cognitive and Metacognitive Perspective (v) Linda Baker O...University of Maryland I Technologies for Skill Acquisition and Retention Training Research Laboratory DTICSELECTE JUL 0 8 1988 H U. S. Army Research...Include Security Classification) Towards Enhancing Written Communication Skills in the Army: Cognitive and Metacognitive Perspective 12. PERSONAL AUTHOR(S

Who, What and How? Commentary on Cheney, F. N. (1963) the Teaching of Reference in American Library Schools. (Journal of Education for Librarianship, 3(3), 188-198)

ERIC Educational Resources Information Center

Smith, Linda C.

2015-01-01

Cheney's paper was the first major article on the subject of teaching reference in American library schools. In the article, she addressed three questions: (1) Who is teaching reference?; (2) What is being taught?; and (3) How is it being taught? In this article, Linda Smith discusses how the teaching of reference has changed in the more than 50…

Interactions Between IGFBP-3 and Nuclear Receptors in Prostate Cancer Apoptosis

DTIC Science & Technology

2009-01-01

Genova, Italy . September 2008. 14 Conclusions Thus, we conclude that IGFBP-3 is a potent apoptosis inducer with potential implications in...11780 Pecan Way Loma Linda, CA 92354 Ph: (909) 799-1510 E-mail: kukwhalee@mednet.ucla.edu Present Position Assistant...Metabolism Utilizing IGFBP-3 KO mice. GRS/IGF 4th International Congress. Genova, Italy . September 2008. Poster presentations Lee, K.-W

Shared Versus Distributed Memory Multiprocessors

DTIC Science & Technology

1991-01-01

multiprocessors should hawe shared or dis.trimuted meieo-% ha~ trr ~ g ’’~ de~i c4~accio;, S Cm teaicners argue S trongly tor Outiding (li15 tri huted...Applications, MIT Press (1985). 161 D. Gajski et el., "Cedar," Proc. Compcon, pp. 306-309 (Spring 19S9). 171 S. Ahuja, N. Carriero and D. Gelernter, "Linda

Gaming: Eat Breakfast, Drink Milk, Play Xbox

ERIC Educational Resources Information Center

O'Hanlon, Charlene

2007-01-01

Plagued by one of the most overweight populaces in the country, the state of West Virginia was looking for a solution to its obesity problem that would appeal to the school-age crowd. It turned to Linda Carson, a professor at West Virginia University's School of Physical Education. Carson recalled witnessing kids lining up in an arcade to play a…

Gene-to-metabolite network for biosynthesis of lignans in MeJA-elicited Isatis indigotica hairy root cultures

PubMed Central

Chen, Ruibing; Li, Qing; Tan, Hexin; Chen, Junfeng; Xiao, Ying; Ma, Ruifang; Gao, Shouhong; Zerbe, Philipp; Chen, Wansheng; Zhang, Lei

2015-01-01

Root and leaf tissue of Isatis indigotica shows notable anti-viral efficacy, and are widely used as “Banlangen” and “Daqingye” in traditional Chinese medicine. The plants' pharmacological activity is attributed to phenylpropanoids, especially a group of lignan metabolites. However, the biosynthesis of lignans in I. indigotica remains opaque. This study describes the discovery and analysis of biosynthetic genes and AP2/ERF-type transcription factors involved in lignan biosynthesis in I. indigotica. MeJA treatment revealed differential expression of three genes involved in phenylpropanoid backbone biosynthesis (IiPAL, IiC4H, Ii4CL), five genes involved in lignan biosynthesis (IiCAD, IiC3H, IiCCR, IiDIR, and IiPLR), and 112 putative AP2/ERF transcription factors. In addition, four intermediates of lariciresinol biosynthesis were found to be induced. Based on these results, a canonical correlation analysis using Pearson's correlation coefficient was performed to construct gene-to-metabolite networks and identify putative key genes and rate-limiting reactions in lignan biosynthesis. Over-expression of IiC3H, identified as a key pathway gene, was used for metabolic engineering of I. indigotica hairy roots, and resulted in an increase in lariciresinol production. These findings illustrate the utility of canonical correlation analysis for the discovery and metabolic engineering of key metabolic genes in plants. PMID:26579184

Partial amino acid sequence of the branched chain amino acid aminotransferase (TmB) of E. coli JA199 pDU11

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feild, M.J.; Armstrong, F.B.

1987-05-01

E. coli JA199 pDU11 harbors a multicopy plasmid containing the ilv GEDAY gene cluster of S. typhimurium. TmB, gene product of ilv E, was purified, crystallized, and subjected to Edman degradation using a gas phase sequencer. The intact protein yielded an amino terminal 31 residue sequence. Both carboxymethylated apoenzyme and (/sup 3/H)-NaBH-reduced holoenzyme were then subjected to digestion by trypsin. The digests were fractionated using reversed phase HPLC, and the peptides isolated were sequenced. The borohydride-treated holoenzyme was used to isolate the cofactor-binding peptide. The peptide is 27 residues long and a comparison with known sequences of other aminotransferases revealedmore » limited homology. Peptides accounting for 211 of 288 predicted residues have been sequenced, including 9 residues of the carboxyl terminus. Comparison of peptides with the inferred amino acid sequence of the E. coli K-12 enzyme has helped determine the sequence of the amino terminal 59 residues; only two differences between the sequences are noted in this region.« less

Monitoring of selected priority and emerging contaminants in the Guadalquivir River and other related surface waters in the province of Jaén, South East Spain.

PubMed

Robles-Molina, José; Gilbert-López, Bienvenida; García-Reyes, Juan F; Molina-Díaz, Antonio

2014-05-01

The province of Jaén counts with four natural parks, numerous rivers, reservoirs and wetlands; moreover, it is probably the region with higher olive oil production in the world, which makes this zone a proper target to be studied based on the European Water Framework Directive 2000/60/CE. The aim of this survey is to monitor a total number of 373 compounds belonging to different families (pesticides, PAHs, nitrosamines, drugs of abuse, pharmaceuticals and life-style compounds) in surface waters located at different points of the province of Jaén. Among these compounds some priority organic substances (regulated by the EU Directive 2008/105/EC) and pollutants of emerging concern (not regulated yet) can be found. A liquid chromatography electrospray time-of-flight mass spectrometry (LC-TOFMS) method covering 340 compounds was developed and applied, together with a gas chromatography triple-quadrupole mass spectrometry (GC-MS/MS) method which enabled the analysis of 63 organic contaminants (30 of these compounds are analyzed by LC-TOFMS as well). From April 2009 to November 2010 a total of 83 surface water samples were collected (rivers, reservoirs and wetlands). In this period numerous organic contaminants were detected, most of them at the ng L(-1) level. The most frequently priority substances found were chlorpyrifos ethyl, diuron and hexachlorobenzene. Within the other groups, the most frequently detected compounds were: terbuthylazine, oxyfluorfen, desethyl terbuthylazine, diphenylamine (pesticide family); fluorene, phenanthrene, pyrene (PAHs group), codeine, paracetamol (pharmaceuticals compounds) and caffeine, nicotine (life-style compounds). As is could be expected, the total concentration of emerging contaminants is distinctly larger than that of priority pollutants, highlighting the importance of continuing with the study of their presence, fate and effects in aquatic environments. However, concentration levels (at the ng per liter level) are low in

Recruitment and Selection of Minorities in High-Tech Organizations. A Sociological Perspective.

DTIC Science & Technology

1984-09-01

Gretchen M. Luebbe Doris R. Entwisle Nancy A. Madden Joyce L. Epstein Kirk Nabors James Fennessey Alejandro Portes Denise C. Gottfredson Donald C. Rickert...Jr. Gary D. Gottfredson Laura Hersh Salganik Linda S. Gottfredson Robert E. Slavin Edward J. Harsch Jane St. John John H. Hollifield Valarie...and intelligence --as the primary determinants of minority and female underrepresentation in high-tech occupations. Despite voluminous research

Medical Rehabilitation Program: 3. Psychological Factors Related to Program Effectiveness

DTIC Science & Technology

1991-08-27

Donaldson’ Craig W. Bischoff Linda K. Hervig’ Cognitive Performance and Psychophysiology Department’ and Physiological Performance and Operational Medicine... Seligman , 1975). The inference that the development of a health problem is the starting point for psychological reactions that culminate in attrition is...mood questionnaire. Psychological Reports 35, 479-484. Seligman , M. E. P. (1975). Helplessness: On depression development and death. San Francisco: WH

Symposium Proceedings on Intervention Programs Aimed at Increasing Minority Participation in Mathematics-Based Fields Held in Washington, DC on 27-28 May 1988

DTIC Science & Technology

1988-05-28

I Seligman (1975), after having observed animals, theorized that people can also become victims of learned helplessness in that they readily perceive...Abramson, Seligman , and Teasdale (1978) hypothesized that the condition-I ing of helplessness causes individuals to attribute their failure to succeed... Linda Hayden, was able to collect and analyze pertinent data relative to the present performance of Saturday Academy alumni when compared to a peer

Use of Marine Fouling Communities to Evaluate the Ecological Effects of Pollution

DTIC Science & Technology

1990-06-01

Released by Under authority of P. F. Seligman , Head S. Yamiamoto, Head Marine Environment Branch Environmental Sciences Division ACKNOWLEDGMENTS I especially...printing, Elaine Corets for help with bryozoan identification; and Linda Oestreich for editorial review of the manuscript and teaching me valuable...research. I sincerely thank Peter Seligman and Sachio Yamamoto for their managerial support and understanding in allowing me to achieve my research

Sediment Budget Analysis; Masonboro Inlet, North Carolina

DTIC Science & Technology

2017-08-15

O. Box 1890 Wilmington, NC 28403 Linda S. Lillycrop U.S. Army Engineer Research and Development Center Coastal and Hydraulics Laboratory 3909...by the Coastal Engineering Branch (CEERD-HN-C) of the Navigation Division (CEERD-HN), U.S. Army Engineer Research and Development Center, Coastal ...Figure 1). It provides an entrance channel connecting the Atlantic Intracoastal Waterway (AIWW) to the Atlantic Ocean. The inlet is protected by

Crewmember activity in the middeck

NASA Image and Video Library

1996-04-26

STS076-370-005 (22-31 March 1996) --- Astronaut Shannon W. Lucid, mission specialist and future cosmonaut guest researcher, appears to enjoy her last hours aboard the Space Shuttle Atlantis before becoming a crew member supporting the Mir-21 mission aboard the Russia's Mir Space Station. Astronaut Linda M. Godwin is partially visible at left as she works at one of the mid deck lockers.

JPL-20170915-CASSINf-0002-Cassini End of Mission Post Event Press ConferenceAVAIL

NASA Image and Video Library

2017-09-15

This press briefing summarizes the end of NASA-ESA's Cassini-Huygens mission to Saturn and presents the final images made by the spacecraft before its planned disintegration in Saturn's atmosphere on September 15, 2017. Featured: Earl Maize, Cassini Program Manager, JPL; Linda Spilker, Cassini Project Scientist, JPL; Julie Webster, Cassini Spacecraft operations Manager, JPL; and Thomas Zurbuchen, Associate Administrator, Science Mission Directorate, NASA HQ.

A National Security Strategy for Sweden: Balancing Risks and Opportunities in the 21st Century

DTIC Science & Technology

2010-04-01

Command and Staff College. International Security Studies: AY10 Coursebook . Montgomery, 2009. Air Command and Staff College. War Studies Course: AY10... Coursebook . Montgomery, 2009. Assadourian, Eric (Project Director at the World Watch Institute). Vital Signs 2007-2008; The Trends that are Shaping Our...Air Command and Staff College International Security Studies: AY10 Coursebook . Montgomery, 2009. Edgar, Johan, Linda Hjerten, Mira Micic and Eric

Proliferation, Potential TMD Roles, Demarcation and ABM Treaty Compatibility.

DTIC Science & Technology

1994-09-01

Dr. Sergei Blagovolin Dr. Stephen Cambone Amb. Sidney Graybeal Dr. Patricia McFate Dr. Alexander Savelyev Mr. Willis Stanley Ms. Linda Vlahos...control, missile defense, and other international security issues. He served as the director of this study. Dr. Alexander Savelyev is Vice President of...Interview with Dr. Sergei Blagovolin and Alexander Savelyev , July 15,1994, 69. Interview with Amb. Kathleen Bailey, former Assistant Director of

Total Copper Analyzer for Rapid In Situ Characterization of Effluent Discharges

DTIC Science & Technology

2008-08-01

Building 345 Airdrome Road Wahiawa, HI 96786 SBWWTP operations superintendent Linda Bingler Battelle Sequim Operations PNNL 1529 West Sequim Bay ...concentration measurements by ICP-MS at the Battelle Marine Sciences Laboratory in Sequim , Washington, and a second sample was sent for analysis by GFAA...Road Sequim , WA 98382 Commercial laboratory liaison Steve West Orion Research, Inc. 500 Cummings Center Beverly, MA 01915 Industry partner A

Data Warehouse Architecture for Army Installations

DTIC Science & Technology

1999-11-01

Laboratory (CERL). Dr. Moonja Kim is Chief, CN-B and Dr. John Bandy is Chief, CN. The technical editor was Linda L. Wheatley, Information Technology...1994. Devlin, Barry, Data Warehouse, From Architecture to Implementation (Addison-Wesley, 1997). Inmon, W.H., Building the Data Warehouse ( John ...Magazine, August 1997. Kimball, Ralph, "Digging into Data Mining," DBMS Magazine, October 1997. Lewison , Lisa, "Data Mining: Intelligent Technology

Fracture Strength of Titanium based Lithium Disilicate and Zirconia Abutment Crowns

DTIC Science & Technology

2017-06-12

to assisting you in your future publication/presentation efforts. LINDA STEEL -GOODWIN, Col, USAF, BSC Director, Clinical Investigations & Research...The specimens were cemented to a titanium-base implant system, subjected to thermocycling and cyclic loading, and fractured in a material testing...being lost. No complications were noted with respect to the abutments and only three crowns had complications (i.e., 2 debonded, 1 excess cement

Effect of Split-File Digital Workflow on Crown Margin Adaptation

DTIC Science & Technology

2017-03-30

you in your future publication/presentation efforts. LINDA STEEL -GOODWIN, Col, USAF, BSC Director, Clinical Investigations & Research Support...METHODS Multiple pilot studies were completed to define a working model with appropriate restoration settings ( cement gap 20 µm, extra cement gap 40...depressions for standardization. Right: Zirconia and e.max restorations had a cement gap (CG) = 20 µm ; extra cement gap (ECG) = 40 µm, and distance to

A Fatigue Management System for Sustained Military Operations

DTIC Science & Technology

2008-03-31

Bradford, Brenda Jones, Margaret Campbell, Heather McCrory, Amy Campbell, Linda Mendez, Juan Cardenas, Beckie Moise, Samuel Cardenas, Fernando...always under the direct observation of research personnel or knowingly monitored from a central control station by closed circuit television, excluding...blocks 1, 5, 9, and 13). Statistical Analyses To determine the appropriate sample size for this study, a power analysis was based on the post

Modeling Interpersonal Trust in Distributed Command and Control Teams

DTIC Science & Technology

2010-06-01

Journal of Applied Psychology, 92(4), 909-927. Dirks, K. T. & Ferrin, D. L. (2001). The role of trust in organizational settings. Organization Science ...Command Performance Research, Inc.), Arwen E. Hunter (U. S. Army Research Institute for the Behavioral and Social Sciences ) & Linda G. Pierce (U. S...Army Research Institute for the Behavioral and Social Sciences ) Command Performance Research, Inc. U. S. Army Research Institute 206 N

Evaluation of DoD Information Analysis Centers Program: Representative Sample Study - Benefits to DoD from Use of DoD Information Analysis Centers

DTIC Science & Technology

1990-06-01

RAC asserted in general terms that the results of IAC special tasks were general increases in the productivity of their owi organization . In...Linda H. Berkhouse 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8.PERFORMING ORGANIZATION REPORT NUMSER Institute for Defense Analyses 1801 N...In still other instances, we were able to obtain firm estimates from users regarding improvements in their organizations ’ productivity, labor

The Probabilities of Unique Events

DTIC Science & Technology

2012-08-30

social justice and also participated in antinuclear demonstrations. The participants ranked the probability that Linda is a feminist bank teller as...investigated them. We propose a new theory (implemented in a computer program) in which such estimates depend on an intuitive non-numerical system capable only...of simple procedures, and a deliberative system that maps intuitions into numbers. The theory predicts that estimates of the probabilities of

Military Competency-Based Human Capital Management: A Step Toward the Future

DTIC Science & Technology

2006-01-27

upon competencies rather than test scores.”3 Competency concepts, however, only truly began to enter the mainstream business sector with the work of Dr...categorized. In a Personnel Psychology article on competency analysis, the following observation by Shippmann, et al., contrasting job analysis...5. 4 Ibid, 5. 5 Shippman, Jeffery S; Ash, Ronald A.; Battista, Mariangela; Carr, Linda; Eyde , Lorraine D.; Hesketh, Beryl; Kehoe, Jerry; Pearlman

Synthesis and mode of action studies of N-[(-)-jasmonyl]-S-tyrosin and ester seiridin jasmonate.

PubMed

Reveglia, Pierluigi; Chini, Andrea; Mandoli, Alessandro; Masi, Marco; Cimmino, Alessio; Pescitelli, Gennaro; Evidente, Antonio

2018-03-01

Recent analyses on fungal jasmonic acid (JA)-containing metabolites suggest a mode-of-action of these naturally occurring compounds as inactive storage pools of JA. Plants and/or fungi can catabolize JA into the bioactive jasmonyl-isoleucine (JA-Ile) that in turn activates the JA-Ile-pathway in planta. To extend our knowledge on JA-derivates related to natural occurring JA conjugates, N-[(-)-jasmonyl]-S-tyrosin (JA-Tyr) and the ester JA-Sei between JA and seiridin, a fungal disubstituted furanone, were synthesized. The classical procedures for ester synthesis were applied for compound JA-Sei, while N-[(-)-jasmonyl]-S-tyrosin was synthesized with an optimized procedure. JA-Tyr and JA-Sei were characterized by spectroscopic method (essentially 1D and 2D NMR spectroscopy and ESI-MS) and their stereochemical composition was determined by means of HPLC and circular dichroism analysis. Finally, the activity of these JA-derivates was analyzed in planta. JA-Tyr and JA-Sei trigger JA-regulated plant responses, such as protein degradation and growth inhibition. These effects require the conversion of JA into JA-Ile and its recognition by the plant JA-Ile perception complex COI1-JAZ. Overall, these data suggest a mode-of-action of JA-Tyr and JA-Sei as inactive pool of JA that can be transformed into the bioactive JA-Ile to induce the canonical JA-Ile-pathway. Copyright © 2017 Elsevier Ltd. All rights reserved.

Unclassified Publications of Lincoln Laboratory, 1 January - 31 December 1991. Volume 17

DTIC Science & Technology

1991-12-31

FIBER OPTIC ANALOG LINK MS-9183 MS-8873 FABRY - PEROT LASER FIBER OPTIC APPLICATIONS JA-6656 JA-6686 FABRY - PEROT SCANNING FIBER OPTIC LINK JA-6567 MS...8532, MS-9353 FABRY - PEROT SPECTRUM ANALYZER FIBER OPTICS TECHNOLOGY JA-6682 JA-6458 FAR-FIELD BEAM DIVERGENCE FIELD EFFECT TRANSISTORS JA-6505 JA-6662...8734 JA-6604, JA-6680 CRAMER-RAO LOWER BOUND DELAY LINES JA-6461 MS-8890 CROSS-CORRELATION DEMODULATION MS-8734 TR-91 0 CROSSLINK DEPOSITION METHODS JA

Use of a standardized JaCVAM in vivo rat comet assay protocol to assess the genotoxicity of three coded test compounds; ampicillin trihydrate, 1,2-dimethylhydrazine dihydrochloride, and N-nitrosodimethylamine.

PubMed

McNamee, J P; Bellier, P V

2015-07-01

As part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiative international validation study of the in vivo rat alkaline comet assay (comet assay), our laboratory examined ampicillin trihydrate (AMP), 1,2-dimethylhydrazine dihydrochloride (DMH), and N-nitrosodimethylamine (NDA) using a standard comet assay validation protocol (v14.2) developed by the JaCVAM validation management team (VMT). Coded samples were received by our laboratory along with basic MSDS information. Solubility analysis and range-finding experiments of the coded test compounds were conducted for dose selection. Animal dosing schedules, the comet assay processing and analysis, and statistical analysis were conducted in accordance with the standard protocol. Based upon our blinded evaluation, AMP was not found to exhibit evidence of genotoxicity in either the rat liver or stomach. However, both NDA and DMH were observed to cause a significant increase in % tail DNA in the rat liver at all dose levels tested. While acute hepatoxicity was observed for these compounds in the high dose group, in the investigators opinion there were a sufficient number of consistently damaged/measurable cells at the medium and low dose groups to judge these compounds as genotoxic. There was no evidence of genotoxicity from either NDA or DMH in the rat stomach. In conclusion, our laboratory observed increased DNA damage from two blinded test compounds in rat liver (later identified as genotoxic carcinogens), while no evidence of genotoxicity was observed for the third blinded test compound (later identified as a non-genotoxic, non-carcinogen). This data supports the use of a standardized protocol of the in vivo comet assay as a cost-effective alternative genotoxicity assay for regulatory testing purposes. Crown Copyright © 2015. Published by Elsevier B.V. All rights reserved.

On Blue Tongues, Undergraduates, and Science: An Interview With Linda M. Bartoshuk

ERIC Educational Resources Information Center

King, Camille Tessitore

2004-01-01

Camille Tessitore King is an Assistant Professor in the Department of Psychology at Stetson University in DeLand, Florida, where she teaches Introduction to Psychology, Great Experiments in Psychology, Biological Psychology, as well as other advanced topic courses such as Drugs and Behavior. She received her BA, MA, and PhD from the University of…

Unclassified Publications of Lincoln Laboratory, 1 January - 31 December 1989. Volume 15

DTIC Science & Technology

1989-12-01

BOLTZMANN MACHINE JA-6051 JA-6290 BEAM PATH CONDITIONING BORON CONTAINING MOLECULES MS-8143 JA-6135 BEAM STEERING BORON TRICHLORIDE MS-8285 JA-6129...BERNZOMATIC TOTE TORCH BORON TRICHLORIDE -ARGON DISCHARGE JA-6260 JA-6129 BIAS CORRELATION BOUNDARY LAYER JA-6326 JA-6192, MS-8141 BINARY INTEGRATION BROADBAND...MS-8345 MODULATORS IRIDIUM MS-7998 JA-6192 67 Subject Index IRIDIUM SILICIDE SCHOTTKY-BARRIER KWAJALEIN DISCRIMINATION SYSTEM INFRARED DETECTORS JA

A Biogeochemical and Spectral Analysis of Vegetation Affected by External Abiotic Agents: Results of an Investigation from Kitsap County, Washington

DTIC Science & Technology

1990-12-01

zinc and arsenic levels in vegetation growing on the landfill compared with the control site . This observation may indicate the value of ground-based...Stanford. CA CANADA \\iateur De Champlain. DS.A.. Matane. Quebec LINDA HALL LIBRARY Doc Dept. Kansas City . MO NATL ACADEMY OF ENGRG Alexandria. VA PRESNELL... site and fromn an elclroJplating acid wvaste disposal site near Bangor. Washington. The samples were mecasured with a spectroradiomecter employing

Inverse Scattering and Applications. Proceedings of Conference on Inverse Scattering on the Line, Held in Amherst, Massachusetts on June 7 - 13, 1990

DTIC Science & Technology

1990-01-01

J. Laurie Snell S. A. Amitsur, D. J. Saltman, and 2 Proceedings of the conference on G. B. Seligman , Editors integration, topology, and geometry in...Rational constructions of modules 17 Nonlinear partial differential equations. for simple Lie algebras, George B. Joel A. Smoller, Editor Seligman 18...number theory, Michael R. Stein and Linda Keen, Editor R. Keith Dennis, Editors 65 Logic and combinatorics, Stephen G. 84 Partition problems in

Dome: Distributed Object Migration Environment

DTIC Science & Technology

1994-05-01

Best Available Copy AD-A281 134 Computer Science Dome: Distributed object migration environment Adam Beguelin Erik Seligman Michael Starkey May 1994...Beguelin Erik Seligman Michael Starkey May 1994 CMU-CS-94-153 School of Computer Science Carnegie Mellon University Pittsburgh, PA 15213 Abstract Dome... Linda [4], Isis [2], and Express [6] allow a pro- grammer to treat a heterogeneous network of computers as a parallel machine. These tools allow the

Accelerating our Second Transformation. 2010 Annual Report

DTIC Science & Technology

2010-01-01

Practice,” by Robert Tremaine and Donna Seligman “Adaptation of Porter’s Five Forces Model to Risk Management,” by John Rice Defense AT&L Magazine The...Stan Rosen John Sarakatsannis Donna Seligman Marty Sherman Steve Skotte Woody Spring Robert Tremaine (Team Lead) Denise Wheaton Andy Zaleski Goal 4...DoD Acquisition Insight Days Conference Team Paul Brierley Bernadette Crumb Linda Perry Susan Shirey Matthew Snedeker Jonathan Specht Jeffrey Tkach

Mission control activity during STS-61 EVA-2

NASA Image and Video Library

1993-12-05

Harry Black, at the Integrated Communications Officer's console in the Mission Control Center (MCC), monitors the second extravehicular activity (EVA-2) of the STS-61 Hubble Space Telescope (HST) servicing mission. Others pictured, left to right, are Judy Alexander, Kathy Morrison and Linda Thomas. Note monitor scene of one of HST's original solar array panels floating in space moments after being tossed away by Astronaut Kathryn C. Thornton.

Forgetting the Lessons of Vietnam: Army Force Structure Changes as a Result of Reduced Budgets

DTIC Science & Technology

2016-02-16

9. 34 Ibid. 35 Ibid. 36 Valerie J. Lofland, “Somalia: U.S. Intervention and Operation Restore Hope” in Case Studies in Policy Making...and Miranda A. Carlton-Carew, 34-67. Washington : The Center for Strategic and International Studies, 2006. 23 Lofland, Valerie J. “Somalia...Szayna, Thomas S., Kevin F. McCarthy, Jerry M. Sollinger, Linda J. Demaine, Jefferson P. Marquis, Brett Steele . The Civil-Military Gap in the

Final Environmental Assessment Addressing Construction of a Fitness Center at Beale Air Force Base, California

DTIC Science & Technology

2009-10-01

adverse impacts on geology and soils would be anticipated due to construction and demolition activities, such as grading, excavation, and...2, during construction and demolition activities would limit adverse impacts on geology and soils. Therefore, no long-term, adverse, direct or...20 99 113 70 70 99 65 70 20 Live Oak Loma Rica Tierra Buena Wheatland Lincoln Linda Marysville Olivehurst South Yuba City Yuba City Source: ESRI

Implementation of an Integrated Orthopedic Curriculum to Increase Clinical and Procedural Competency amongst Pediatric Residents

DTIC Science & Technology

2017-04-05

59 MDW/SGVU SUBJECT: Professional Presentation Approval 7 FEB 2016 1. Your paper, entitled Implementation of an Integrated Orthopedic Curriculum... Research Division inay pay for your basic journal publishing charges (to include costs for tables and black and white photos). We cannot pay for...efforts. LnJ.a ~~e.\\- b,.,.,d~Wi LINDA STEEL-GOODWIN;Col, USAF, BSC Director, Clinical Investigations & Research Support Warrior Medics - Mission Ready

59th Clinical Research Division Research Day Briefing

DTIC Science & Technology

2016-10-27

59th Medical Wing a ’r’. ’ ( ~ ~ ’ ""· ~... ’ .,,,. lS! lflof!’~l. 59th Clinical Research Division Research Day Briefing Colonel Linda Steel...oversight and guidance to researchers in the development, performance, and dissemination of clinical investigations. CRD directly supports wing...Clinical Investigation Support 2. Training 3. Support of RDT&E protocols 4. Research Subject Protection • Human Subjects: IRS - Institutional

A Study of Precipitation Occurrence Using Visual and Infrared Satellite Data.

DTIC Science & Technology

1983-12-01

THESIS A STUDY OF PRECIPITATION OCCURRENCE USING VISUAL AND INFRARED SATELLITE DATA by Linda Sue Paul December 1983 L1J Thesis Advisor: C . H. Wash Approved...PRECIPITATION SPECIFICATION ............ 18 A. INTRODUCTICI O N ...... • ........ 18 B. BI-SPECTRAL AND INFRARID THRBSH3LD ...... 18 C . LIFE HISTORY 3...4 III. DATA PROCESSING * .• ....... * ...... 󈧮 A. INTRODUCTION o . . . . . .o. . . o o . o 2 B. C ATA SORT o . o . . o o

All-Hazard Consequence Management Planning for the Water Sector: Preparedness, Emergency Response, and Recovery CIPAC Workshop

DTIC Science & Technology

2009-11-01

subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE...of Health Mark Miller Centers for Disease Control and Prevention National Center for Environmental Health Debbie Newberry, co-chair US EPA...Utilities Linda Eichmiller Association of State and Interstate Water Pollution Control Administrators Jeff Fencil US EPA Office of Ground Water and

Charleston Harbor, SC, Regional Sediment Management Study; Beneficial Use of Dredged Material through Nearshore Placement

DTIC Science & Technology

2017-05-01

Project 454632, “Charleston Harbor, SC, Regional Sediment Management Study” Project . The HQUSACE RSM Program Manager was Ms. Linda S. Lillycrop, U.S. Army...objective of the U.S. Army Corps of Engineers (USACE) RSM Program is to improve the management of sediments across multiple projects , manage sediments as a...optimize use of sediments and streamline projects . The adaptive management strategies are developed and implemented through application of the best

Charleston Harbor, SC, Regional Sediment Management Study: Beneficial Use of Dredged Material through Nearshore Placement

DTIC Science & Technology

2017-05-01

Project 454632, “Charleston Harbor, SC, Regional Sediment Management Study” Project . The HQUSACE RSM Program Manager was Ms. Linda S. Lillycrop, U.S. Army...objective of the U.S. Army Corps of Engineers (USACE) RSM Program is to improve the management of sediments across multiple projects , manage sediments as a...optimize use of sediments and streamline projects . The adaptive management strategies are developed and implemented through application of the best

Dynamic Data Driven Operator Error Early Warning System

DTIC Science & Technology

2015-08-13

calibrations, participants started to do the experiment with a 3-minute baselining session. They were rested and listened to the music Bachs Harpsichord...conditions. Further, training data is not necessary to perform the PCA analysis presented here. The second method is the least squares complex...approach for operational modal analysis. In Proceedings of the 25th IMAC, Orlando (FL), USA, 2007. [4] Linda Chlan. Effectiveness of a music therapy

Observations on the Biology of Afrotropical Hesperiidae (Lepidoptera) with particular reference to Kenya. Part 11. Heteropterinae.

PubMed

Cock, Matthew J W; Congdon, T Colin E

2017-01-30

Partial life histories from Kenya or Tanzania are presented for Metisella midas midas (Butler), M. medea medea Evans, M. orientalis orientalis Aurivillius, M. quadrisignatus nanda Evans, M. congdoni De Jong & Kielland and M. willemi Wallengren. The ovum of Metisella formosus linda Evans is also illustrated from Zambia. All feed on species of grasses (Poaceae). The convergence of the biology of the grass-feeding skippers, particularly Heteropterinae and Hesperiinae, Baorini is discussed.

The Supply Effectiveness of Cooperative Logistics.

DTIC Science & Technology

1979-06-01

comparisins need special attention. One- Wav ANOVA The critical item data were run on the computer using the subprogram One-Way (lo:422-425) to...thesis midi -proposal, LSSR 3-79B, Air Force Institute of Technology, Wright-Patterson AFB OH, February 1979. 6. Christenson, Linda. Supply Systems...Pricing Procedures." Unpublished thesis midi -proposal. LSSR 8-79B, Air Force Institute of Technology, Wright-Patterson AFB OH, February 1979. 28

Identity Management Task Force Report 2008

DTIC Science & Technology

2008-01-01

Telecommunication Grid ( GTG ) consists of the public- switched telecommunications network (PSTN), various forms of Internet protocol (IP) networks...to network providers) to a large community of nomadic users and access devices over a wide range of access technologies. The GTG is notional, and...DOC Dr. Myra Gray , DOD Greg Hall, DNI Celia Hanley, DOD Patrick Hannon, DNI James Hass, IC Linda Hill, SSA Bobby Jones, DOC Patrick Hannon

Commercial Digital/ADP Equipment in the Ocean Environment. Volume 2. User Appendices

DTIC Science & Technology

1978-12-15

is that the LINDA system uses a mini computer with a time sharing system software which allows several terminals to be operated at the same time...Acquisition System (ODAS) consists of sensors, computer hardware and computer software . Certain sensors are interfaced to the computers for real time...on USNS KANE, USNS BENT, and USKS WILKES. Commercial automatic data processing equipment used in ODAS includes: Item Model Computer PDP-9 Tape

Early Prediction of Lupus Nephritis Using Advanced Proteomics

DTIC Science & Technology

2009-06-01

We are working with our collaborators at the Applied Biotechnology Branch, A ir Force Research Lab, W right-Patterson Air Force Base, to accomplish...with systemic lupus erythematosus. Arthritis Rheum 2001;44:2350–7. 33. Zappitelli M, Duffy CM, Bernard C, Gupta IR . Evaluation of activity, chronicity...Children’s Hospital, Chicago, IL: Dr. Linda Wagner-Weiner (data collection); Becky Puplava (study coordinator). University of Okla- homa Health Sciences

Unclassified Publications of Lincoln Laboratory 1 January - 31 December 1994, Volume 20.

DTIC Science & Technology

1994-12-31

J. Ehrlich, DJ. Hollis, M.A. Kosicki, B.B. Powdrill, T. Beattie, K. Smith, S. Varma, R. Gangadharan, R. Mallik , A. Burke, B.E. Wallace, D...JA-6972, JA-7028 Mallik , A., JA-7164 Manfra, M.J., JA-7027, MS-10604 Mankiewich, P.M., JA-7001 Maragos, P., JA-6764, JA-6888 Marcus, S., JA-6898

Conference Proceedings: “Down Syndrome: National Conference on Patient Registries, Research Databases, and Biobanks”

PubMed Central

Oster-Granite, Mary Lou; Parisi, Melissa A.; Abbeduto, Leonard; Berlin, Dorit S.; Bodine, Cathy; Bynum, Dana; Capone, George; Collier, Elaine; Hall, Dan; Kaeser, Lisa; Kaufmann, Petra; Krischer, Jeffrey; Livingston, Michelle; McCabe, Linda L.; Pace, Jill; Pfenninger, Karl; Rasmussen, Sonja A.; Reeves, Roger H.; Rubinstein, Yaffa; Sherman, Stephanie; Terry, Sharon F.; Whitten, Michelle Sie; Williams, Stephen; McCabe, Edward R.B.; Maddox, Yvonne T.

2011-01-01

A December 2010 meeting, “Down Syndrome: National Conference on Patient Registries, Research Databases, and Biobanks,” was jointly sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) at the National Institutes of Health (NIH) in Bethesda, MD, and the Global Down Syndrome Foundation (GDSF)/Linda Crnic Institute for Down Syndrome based in Denver, CO. Approximately 70 attendees and organizers from various advocacy groups, federal agencies (Centers for Disease Control and Prevention, and various NIH Institutes, Centers, and Offices), members of industry, clinicians, and researchers from various academic institutions were greeted by Drs. Yvonne Maddox, Deputy Director of NICHD, and Edward McCabe, Executive Director of the Linda Crnic Institute for Down Syndrome. They charged the participants to focus on the separate issues of contact registries, research databases, and biobanks through both podium presentations and breakout session discussions. Among the breakout groups for each of the major sessions, participants were asked to generate responses to questions posed by the organizers concerning these three research resources as they related to Down syndrome and then to report back to the group at large with a summary of their discussions. This report represents a synthesis of the discussions and suggested approaches formulated by the group as a whole. PMID:21835664

An Investigation of the Causes of the Coronary-Prone (Type A) Behavior Pattern and Coronary Heart Disease.

DTIC Science & Technology

1983-09-01

experiences. Uncontrollable Stress Uncontrollable stress arises when an individual’s outcome is not determined by his/her response to a situation. Seligman ... Linda Hervig, and Ray H. Rosenman. "Heritability of Type A Behavior," Psychosomatic Medicine, 40, No. 6 (1978), pp. 478-486. , Robert T. Rubin, and...Performance, 25 (1980), pp. 184-215. Seligman , M. E. P. Helplessness: On Depression, Develop- ment, and Death. San Francisco: Freeman, 1975. Tamir, I., G

Evaluating the Combined UUV Efforts in a Large-Scale Mine Warfare Environment

DTIC Science & Technology

2015-03-01

buddy, COL Fred Lough and Mary Mullin, for being loving and support parents-in-law, and Linda and Harry Thompson, for being the most devoted and...completed in 2015. Until the RMMV and AQS-20B issues are resolved, the RMS operational test cannot be completed onboard LCS ( Seligman , 2015). These poor...available in the foreseeable future. Therefore, the Avenger-Class ships will remain the main MCM platform ( Seligman , 2014). The Avenger-Class ships are

Conference Proceedings. Defense Modeling and Simulation Office Information/Data Base (I/DB) Task Group Meetings Held February 14-18, 1994, and Notes from the Previous Two I/DB Meetings

DTIC Science & Technology

1994-01-01

DB Task Group co-chairs would like to thank Mrs. Janice Hirst of IDA for her help in coordinating and supporting the I/DBTG meetings and Ms. Linda ...Data (co-chairs Len Seligman (Mitre) and Pete Valentine (Army/JDBE)): will start with several recent categorization attempts including those offered in...fbrmed to address categorization of complex data co-chaired by Len Seligman (Mitre) and Pete Valentine (Army/JDBE)); (2) a subgroup to deal with

Natural Resources Research Program: Proceedings of a Workshop on Operational Management Plans: Improving the Process Held in Arlington, Texas on 5-7 December 1989

DTIC Science & Technology

1991-03-01

direction of the work unit was changed to focus on exchanging information in the form of a workshop. It was * eyman-Dove, Linda, Waring, Michael R., and...plan should be broad in scope and evolutionary in principle to permit subsequent revisions neces- sary to fit changing conditions." Cost estimates for...began to update guidance to the field offices in the area of recreation and natural resource manage- ment. Times had changed . New water resource

International Conference on Immunogenetics of the Rabbit.

DTIC Science & Technology

1983-12-09

Md. 20205 We have recently described a method for the direct removal of T lymphocytes by " panning " of rabbit splenocytes on plastic dishes coated...Research University of Illinois Washington, DC 20012 Chicago, IL 60612 Hammadi Ayadi Linda Cook Institut Jacques Monod University of Illinois, Chicago...other species and tested for its ability to inhibit a rabbit Id-anti-Id reaction. Guinea pigs, mice, goats, and chickens were immunized with al IgG and

Incompatible Systems of Logic: Why Design Should Integrate the Mechanistic, Reductionist, and Linear Logic of Military Detailed Planning

DTIC Science & Technology

2011-05-19

24 Eva Boxenbaum, Linda Rouleau, New Knowledge Products as Bricolage : Metaphors and Scripts in Organizational Theory, (Academy of Management Review...marginalize it by reducing it into a supplement to detailed planning methodology. This process of knowledge production, defined as “ bricolage ” in...Boxenbaum, Rouleau, 280-281. A ‘bricoleur’ is a person that conducts ‘ bricolage ’ with new knowledge production. 48 Field Manual 5-0. 1-5, 1-6, 3-1

The Consequences for Women of the Availability and Affordability of Child Care

DTIC Science & Technology

1988-07-01

00 THE CONSEQUENCES FOR WOMEN OF THE AVAILABILITY AND AFFORDABILITY OF CHILD CARE Arleen Leibowitz Linda J. Waite July 1988 DTI -%ELECTEE NOV07 IM P...Research Council’s Committee on Child Care. It focuses on the effects for women of the availability and affordability of child care, concentrating...especially on effects on women’s employment and earnings. The paper discusses the implications of raising the wages of child care workers, of the

Cosmonauts and astronauts during medical operations training

NASA Image and Video Library

1994-06-11

Astronaut Norman E. Thagard (right center), a guest researcher on Russia's Mir 18 mission, monitors a test of a subject (out of frame) in the Lower Body Negative Pressure (LBNP) device. Others pictured, left to right, are Todd Schlegel (seated) of the Medical Sciences Division at JSC, unidentified trainer, Linda Barrows of Krug; cosmonaut Vladimir N. Dezhurov, mission commander; cosmonaut Gennadiy M. Strekalov, Thagard and cosmonaut Alexsandr F. Poleshchuk, Mir 18 reserve flight engineer.

Environmental Analysis of Lake Pontchartrain, Louisiana, Its Surrounding Wetlands, and Selected Land Uses. Volume 2.

DTIC Science & Technology

1980-02-01

CHAPTER 1: PRELIMINARY MODELING OF THE LAKE PONTCHARTRAIN ECOSYSTEM BY COMPUTER SIMULATIONS Janes H. Stone and Linda A. Deegan ...related to the extent and productivity of intertidal wetlands ( Craig et al. 1979). The role of coastal wetlands in estuarine areas has been well documented...site arid a bottomland harlwood stt c ill I Iouisiana swamp. Amer. J. Bot. 63 (10):1354-1364. Craig , N. J., R. E. Turner, aird J. W. Day, Jr. 197

The National Guard Ballistic Missile Defense Mission: Minutemen at the Orbital Plane

DTIC Science & Technology

2004-09-01

2001, he guided me through a change in Thesis Topic, an extension, an interruption while mobilized for Operation Enduring Freedom, the final extension...Command changes its focus.” Army News Service, Washington, DC. Copy obtained from the Internet at [http://www.defenselink.mil] (15 July 1996). 4...testing phase. 12 Kozaryn, Linda D., “Army Reserve Duty Has ’ Changed Forever’” The comments of US Army Reserve Chief, Lt. Gen. Thomas J. Plewes

Integrity Verification for SCADA Devices Using Bloom Filters and Deep Packet Inspection

DTIC Science & Technology

2014-03-27

prevent intrusions in smart grids [PK12]. Parthasarathy proposed an anomaly detection based IDS that takes into account system state. In his implementation...Security, 25(7):498–506, 10 2006. [LMV12] O. Linda, M. Manic, and T. Vollmer. Improving cyber-security of smart grid systems via anomaly detection and...6 2012. 114 [PK12] S. Parthasarathy and D. Kundur. Bloom filter based intrusion detection for smart grid SCADA. In Electrical & Computer Engineering

Rotorcraft Low Altitude IFR Benefit/Cost Analysis: Operations Analysis

DTIC Science & Technology

1991-12-01

Anoll Len D. Dzamba Linda J. LaBelle Randahl N. Lindgren Robert B. Newman Deborah J. Peisen Systems Control Technology , Inc. 1611 N. Kent Street, Suite...Lindgren, Robert B. Newman, Deborah J. Peisen 9. Performing Organization Name and Address 10. Work Unit No. (TRAIS) Systems Control Technology , Inc. 1611...headquarters of United Technology /Sikorsky to get them through this area. 5.7.3.3 Communications Coverage Corporate/executive operators were well satisfied

National Security Consequences of U.S. Oil Dependency

DTIC Science & Technology

2006-11-09

J. DiBona Sentient Council Jessica P. Einhorn Paul H. Nitze School of Advanced International Studies Martin S. Feldstein National Bureau of Economic...Croft James R. Schlesinger John Deutch Peter Schwartz Charles J. DiBona Philip R. Sharp Jessica P. Einhorn James B. Steinberg Martin S. Feldstein Linda G...Director of Central Intelligence. Charles J. DiBona is the current Chairman of the Sentient Council and retired Chairman of the Board of Logistics

STS-37 Mission Specialist (MS) Godwin floating in life raft in JSC WETF pool

NASA Technical Reports Server (NTRS)

1990-01-01

STS-37 Mission Specialist (MS) Linda M. Godwin, wearing launch and entry suit (LES) and launch and entry helmet (LEH), floats in a one-person life raft during a training session in JSC's Weightless Environment Training Facility (WETF) Bldg 29 pool. She was simulating steps involved in emergency egress from a Space Shuttle. The WETF's 25-ft deep pool served as a simulated ocean into which a parachute landing might be made.

Sub-Saharan Africa Report.

DTIC Science & Technology

1985-11-25

25 Oct 85) 88 RSA Fruit Imports Embarrass Irish (Linda Ensor; BUSINESS DAY, 23 Oct 85) 89 Development of Mossel Bay Gas Planned (Tony Stirling...Bureau of the Gabonese Democratic Party which was led by Michel Essonghe, personal minister counselor 0f President Bongo and minister of civil and...tion of non-traditional products like fruits and vegetables which need less import content in the form of machinery for their processing, and •are

Endoplasmic reticulum-associated inactivation of the hormone jasmonoyl-L-isoleucine by multiple members of the cytochrome P450 94 family in Arabidopsis.

PubMed

Koo, Abraham J; Thireault, Caitlin; Zemelis, Starla; Poudel, Arati N; Zhang, Tong; Kitaoka, Naoki; Brandizzi, Federica; Matsuura, Hideyuki; Howe, Gregg A

2014-10-24

The plant hormone jasmonate (JA) controls diverse aspects of plant immunity, growth, and development. The amplitude and duration of JA responses are controlled in large part by the intracellular level of jasmonoyl-L-isoleucine (JA-Ile). In contrast to detailed knowledge of the JA-Ile biosynthetic pathway, little is known about enzymes involved in JA-Ile metabolism and turnover. Cytochromes P450 (CYP) 94B3 and 94C1 were recently shown to sequentially oxidize JA-Ile to hydroxy (12OH-JA-Ile) and dicarboxy (12COOH-JA-Ile) derivatives. Here, we report that a third member (CYP94B1) of the CYP94 family also participates in oxidative turnover of JA-Ile in Arabidopsis. In vitro studies showed that recombinant CYP94B1 converts JA-Ile to 12OH-JA-Ile and lesser amounts of 12COOH-JA-Ile. Consistent with this finding, metabolic and physiological characterization of CYP94B1 loss-of-function and overexpressing plants demonstrated that CYP94B1 and CYP94B3 coordinately govern the majority (>95%) of 12-hydroxylation of JA-Ile in wounded leaves. Analysis of CYP94-promoter-GUS reporter lines indicated that CYP94B1 and CYP94B3 serve unique and overlapping spatio-temporal roles in JA-Ile homeostasis. Subcellular localization studies showed that CYP94s involved in conversion of JA-Ile to 12COOH-JA-Ile reside on endoplasmic reticulum (ER). In vitro studies further showed that 12COOH-JA-Ile, unlike JA-Ile, fails to promote assembly of COI1-JAZ co-receptor complexes. The double loss-of-function mutant of CYP94B3 and ILL6, a JA-Ile amidohydrolase, displayed a JA profile consistent with the collaborative action of the oxidative and the hydrolytic pathways in JA-Ile turnover. Collectively, our results provide an integrated view of how multiple ER-localized CYP94 and JA amidohydrolase enzymes attenuate JA signaling during stress responses. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Endoplasmic Reticulum-associated Inactivation of the Hormone Jasmonoyl-l-Isoleucine by Multiple Members of the Cytochrome P450 94 Family in Arabidopsis*

PubMed Central

Koo, Abraham J.; Thireault, Caitlin; Zemelis, Starla; Poudel, Arati N.; Zhang, Tong; Kitaoka, Naoki; Brandizzi, Federica; Matsuura, Hideyuki; Howe, Gregg A.

2014-01-01

The plant hormone jasmonate (JA) controls diverse aspects of plant immunity, growth, and development. The amplitude and duration of JA responses are controlled in large part by the intracellular level of jasmonoyl-l-isoleucine (JA-Ile). In contrast to detailed knowledge of the JA-Ile biosynthetic pathway, little is known about enzymes involved in JA-Ile metabolism and turnover. Cytochromes P450 (CYP) 94B3 and 94C1 were recently shown to sequentially oxidize JA-Ile to hydroxy (12OH-JA-Ile) and dicarboxy (12COOH-JA-Ile) derivatives. Here, we report that a third member (CYP94B1) of the CYP94 family also participates in oxidative turnover of JA-Ile in Arabidopsis. In vitro studies showed that recombinant CYP94B1 converts JA-Ile to 12OH-JA-Ile and lesser amounts of 12COOH-JA-Ile. Consistent with this finding, metabolic and physiological characterization of CYP94B1 loss-of-function and overexpressing plants demonstrated that CYP94B1 and CYP94B3 coordinately govern the majority (>95%) of 12-hydroxylation of JA-Ile in wounded leaves. Analysis of CYP94-promoter-GUS reporter lines indicated that CYP94B1 and CYP94B3 serve unique and overlapping spatio-temporal roles in JA-Ile homeostasis. Subcellular localization studies showed that CYP94s involved in conversion of JA-Ile to 12COOH-JA-Ile reside on endoplasmic reticulum (ER). In vitro studies further showed that 12COOH-JA-Ile, unlike JA-Ile, fails to promote assembly of COI1-JAZ co-receptor complexes. The double loss-of-function mutant of CYP94B3 and ILL6, a JA-Ile amidohydrolase, displayed a JA profile consistent with the collaborative action of the oxidative and the hydrolytic pathways in JA-Ile turnover. Collectively, our results provide an integrated view of how multiple ER-localized CYP94 and JA amidohydrolase enzymes attenuate JA signaling during stress responses. PMID:25210037

LOW-TEMPERATURE ION TRAP STUDIES OF N{sup +}({sup 3} P{sub ja} ) + H{sub 2}(j) {yields} NH{sup +} + H

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zymak, I.; Hejduk, M.; Mulin, D.

2013-05-01

Using a low-temperature 22-pole ion trap apparatus, detailed measurements for the title reaction have been performed between 10 K and 100 K in order to get some state specific information about this fundamental hydrogen abstraction process. The relative population of the two lowest H{sub 2} rotational states, j = 0 and 1, has been varied systematically. NH{sup +} formation is nearly thermo-neutral; however, to date, the energetics are not known with the accuracy required for low-temperature astrochemistry. Additional complications arise from the fact that, so far, there is no reliable theoretical or experimental information on how the reactivity of themore » N{sup +} ion depends on its fine-structure (FS) state {sup 3} P{sub ja} . Since in the present trapping experiment, thermalization of the initially hot FS population competes with hydrogen abstraction, the evaluation of the decay of N{sup +} ions over long storage times and at various He and H{sub 2} gas densities provides information on these processes. First assuming strict adiabatic behavior, a set of state specific rate coefficients is derived from the measured thermal rate coefficients. In addition, by recording the disappearance of the N{sup +} ions over several orders of magnitude, information on nonadiabatic transitions is extracted including FS-changing collisions.« less

Conference Proceedings of Defense Modeling and Simulation Office Information/Data Base Technology Working Group (I/DBTWG) Meetings Held During the Week of July 11-15, 1994

DTIC Science & Technology

1994-07-15

xi- ACKNOWLEDGMENTS The I/DBTWG co-chairs would like to thank Ms. Linda Quicker of RAND for her efforts in coordinating the I/DBTWG meeting and...Subgroup on Authoritative Data Sources: Mr. Bill Dunn 0930-0945 Report from M&S Complex Data Task Force Subgroup on Categorization: Mr. Len Seligman ...issues; and need to address maintenance of the Authoritative Data Source directory by DMSO/IAC. - 15- Mr. Len Seligman : Report from M&S Complex Data Tasm

Stennis Space Center observes 2009 Energy Awareness Day

NASA Technical Reports Server (NTRS)

2009-01-01

Stennis Space Center employees Maria Etheridge (l to r), Linda Sauland Maurice Prevost visit a Coast Electric Power Association display featuring energy-efficient light bulbs during 2009 Energy Awareness Day activities on Oct. 20. The exhibit was one of several energy-efficiency and energy-awareness displays on-site for employees to visit. Vendors included Mississippi Power Company, Coast Electric Power Association, Mississippi Development Authority - Energy Division,Jacobs FOSC Environmental, Southern Energy Technologies, and Siemens Building Technologies.

A hospital's teamwork and CQI advance shared vision, interdependence among top managers. Interview by Paula Eubanks.

PubMed

Biltz, J; Mild, L

1992-09-20

As quality improvement programs are initiated in growing numbers of hospitals, senior executives in those hospitals find themselves addressing a range of issues: team building, leadership and interpersonal interaction. CEO Jim Biltz and nurse executive Linda Mild of 760-bed HCA Wesley Medical Center, Wichita, KS, tell Hospitals Staff Editor Paula Eubanks how their participative management style and the hospital's continuous quality improvement (CQI) initiative have fostered new levels of teamwork and shared vision among the institution's top managers.

The Effects of Dopamine and Estrogen Upon Cortical Parvalbumin Expression

DTIC Science & Technology

2001-01-01

Tavedi and Susan Alcala for their valuable technical assistance . This work was supported by NIH NS27038 and USUHS RO7096 to Linda L. Porter. 7 Abstract...postnatal days. All procedures were done in accordance with the NIH guide for the care and use of animals as outlined in a protocol approved by the USUHS...250 µm coronal sections. Slices were washed into cold dissecting medium and separated by gentle agitation using a fire polished wide aperture pipette

Operating Systems Standards Working Group (OSSWG) Next Generation Computer Resources (NGCR) Program First Annual Report - October 1990

DTIC Science & Technology

1991-04-01

Rich Bergman NOSC Dale Brouhard NOSC Stephen Cecil CRANE Tom Conrad NUSC Linda Elderhorst NATC Karen Gordon IDA Daniel Green NSWC Steve Howell NSWC Phil...dictate. Some mods for SAFENET have been 22 acceptable to joint WG, some not. 23 o Vendors make prototype and these are evaluated for 24 conformance by...Need to make 13 recommendation to NGCR concern what is feasible for I 34 O.S. 15 o Language binding and/or language independent? Make 16

Use of the Videophone to Collect Quality of Life Data from Burn Patients

DTIC Science & Technology

2012-12-15

from burn patients Linda H Yoder1, D Curk McFall2, Leopoldo C Cancio3 1The University of Texas at Austin, School of Nursing , 1710 Red River Austin, TX...78701; 2The University of Texas at Austin, School of Nursing , 1710 Red River, Austin, TX 78701; 3U.S. Army Institute of Surgical Research, 3698...technology, however, is available to all provid- ers within the healthcare team, to include researchers. Through the use of telehealth, nurses

United States Air Force Research Initiation Program. 1985 Technical Report. Volume 3.

DTIC Science & Technology

1987-04-01

miners exposed to airborne radon (7). Thus the major health effect associated with radon is thought to be production of lung cancers by radon decay...Based Instruction: Effect Dr. Linda J. Buehner of Cognitive Style, Instructional Format, and Subject-Matter Content 160-OMG-085 9 Nonlinear Feedback...Instrumentation 760-OMG-042 16 Investigation of the Effects of Dr. David R. Cochran an Applied Electric Field on the InP Melt 760-OMG-014 17 Below-Melt

Avation Safety Reporting System (ASRS) 40th Anniversary

NASA Image and Video Library

2016-09-28

Avation Safety Reporting System (ASRS) 40th Anniversary lunch and open house at the Sunnyvale office. Thomas A Edwards, Deputy Center Director NASA Ames (Left), presents a plaque On the anniversary of the aviation safety reporting system, this award is in recognition of 18 years of outstanding leadership as Program Director, resulting in strong program growth, expanded partnership and a widely recognized impact on National and Global transportation safety. Presented to Linda J. Connell, ASRS Program Director (Right)

Stennis Space Center observes 2009 Energy Awareness Day

NASA Image and Video Library

2009-10-20

Stennis Space Center employees Maria Etheridge (l to r), Linda Sauland Maurice Prevost visit a Coast Electric Power Association display featuring energy-efficient light bulbs during 2009 Energy Awareness Day activities on Oct. 20. The exhibit was one of several energy-efficiency and energy-awareness displays on-site for employees to visit. Vendors included Mississippi Power Company, Coast Electric Power Association, Mississippi Development Authority - Energy Division,Jacobs FOSC Environmental, Southern Energy Technologies, and Siemens Building Technologies.

STS-59 crewmembers in training for onboard Earth observations

NASA Technical Reports Server (NTRS)

1993-01-01

The six astronauts in training for the STS-59 mission are shown onboard Earth observations tips by Justin Wilkinson (standing, foreground) of the Space Shuttle Earth Observations Project (SSEOP) group. Astronaut Sidney M. Gutierrez, mission commander, is at center on the left side of the table. Others, left to right, are Astronauts Kevin P. Chilton, pilot; Jerome (Jay) Apt and Michael R.U. (Rich) Clifford, both mission specialists; Linda M. Godwin, payload commander; and Thomas D. Jones, mission specialist.

A Leadership Competency Model for U.S. Air Force Wing Chaplains

DTIC Science & Technology

2009-02-12

45th Annual Conference of the International Military Testing Association, 3-6 November 2003, Pensacola, FL, 721-33, http://www.interrnationalmta.org...2005). 19 31 David C. McClelland, “ Testing for Competence Rather than for ‘Intelligence,’” American Psychologist 28, no. 1 (1973): 1-14. 32 C.K...Ronald Ash, Mariana Batista, Linda Carr, Lorraine D. Eyde , Beryl Hesketh, Jerry Kehoe, Kenneth Pearlman, Erich Prien, and Juan I. Sanchez, “The Practice of

Jasmonic acid/methyl jasmonate accumulate in wounded soybean hypocotyls and modulate wound gene expression.

PubMed

Creelman, R A; Tierney, M L; Mullet, J E

1992-06-01

Jasmonic acid (JA) and its methyl ester, methyl jasmonate (MeJA), are plant lipid derivatives that resemble mammalian eicosanoids in structure and biosynthesis. These compounds are proposed to play a role in plant wound and pathogen responses. Here we report the quantitative determination of JA/MeJA in planta by a procedure based on the use of [13C,2H3]MeJA as an internal standard. Wounded soybean (Glycine max [L] Merr. cv. Williams) stems rapidly accumulated MeJA and JA. Addition of MeJA to soybean suspension cultures also increased mRNA levels for three wound-responsive genes (chalcone synthase, vegetative storage protein, and proline-rich cell wall protein) suggesting a role for MeJA/JA in the mediation of several changes in gene expression associated with the plants' response to wounding.

Gene Expression Profiling Confirms the Dosage-Dependent Additive Neuroprotective Effects of Jasminoidin in a Mouse Model of Ischemia-Reperfusion Injury.

PubMed

Li, Haixia; Wang, Jingtao; Wang, Pengqian; Zhang, Yingying; Liu, Jun; Yu, Yanan; Li, Bing; Wang, Zhong

2018-01-01

Recent evidence demonstrates that a double dose of Jasminoidin (2·JA) is more effective than Jasminoidin (JA) in cerebral ischemia therapy, but its dosage-effect mechanisms are unclear. In this study, the software GeneGo MetaCore was used to perform pathway analysis of the differentially expressed genes obtained in microarrays of mice belonging to four groups (Sham, Vehicle, JA, and 2·JA), aiming to elucidate differences in JA and 2·JA's dose-dependent pharmacological mechanism from a system's perspective. The top 10 enriched pathways in the 2·JA condition were mainly involved in neuroprotection (70% of the pathways), apoptosis and survival (40%), and anti-inflammation (20%), while JA induced pathways were mainly involved in apoptosis and survival (60%), anti-inflammation (20%), and lipid metabolism (20%). Regarding shared pathways and processes, 3, 1, and 3 pathways overlapped between the Vehicle and JA, Vehicle and 2·JA, and JA and 2·JA conditions, respectively; for the top ten overlapped processes these numbers were 3, 0, and 4, respectively. The common pathways and processes in the 2·JA condition included differentially expressed genes significantly different from those in JA. Seven representative pathways were only activated by 2·JA, such as Gamma-Secretase regulation of neuronal cell development. Process network comparison indicated that significant nodes, such as alpha-MSH , ACTH , PKR1 , and WNT , were involved in the pharmacological mechanism of 2·JA. Function distribution was different between JA and 2·JA groups, indicating a dosage additive mechanism in cerebral ischemia treatment. Such systemic approach based on whole-genome multiple pathways and networks may provide an effective and alternative approach to identify alterations underlining dosage-dependent therapeutic benefits of pharmacological compounds on complex disease processes.

Jasmonic acid/methyl jasmonate accumulate in wounded soybean hypocotyls and modulate wound gene expression.

PubMed Central

Creelman, R A; Tierney, M L; Mullet, J E

1992-01-01

Jasmonic acid (JA) and its methyl ester, methyl jasmonate (MeJA), are plant lipid derivatives that resemble mammalian eicosanoids in structure and biosynthesis. These compounds are proposed to play a role in plant wound and pathogen responses. Here we report the quantitative determination of JA/MeJA in planta by a procedure based on the use of [13C,2H3]MeJA as an internal standard. Wounded soybean (Glycine max [L] Merr. cv. Williams) stems rapidly accumulated MeJA and JA. Addition of MeJA to soybean suspension cultures also increased mRNA levels for three wound-responsive genes (chalcone synthase, vegetative storage protein, and proline-rich cell wall protein) suggesting a role for MeJA/JA in the mediation of several changes in gene expression associated with the plants' response to wounding. Images PMID:1594598

Down syndrome: national conference on patient registries, research databases, and biobanks.

PubMed

Oster-Granite, Mary Lou; Parisi, Melissa A; Abbeduto, Leonard; Berlin, Dorit S; Bodine, Cathy; Bynum, Dana; Capone, George; Collier, Elaine; Hall, Dan; Kaeser, Lisa; Kaufmann, Petra; Krischer, Jeffrey; Livingston, Michelle; McCabe, Linda L; Pace, Jill; Pfenninger, Karl; Rasmussen, Sonja A; Reeves, Roger H; Rubinstein, Yaffa; Sherman, Stephanie; Terry, Sharon F; Whitten, Michelle Sie; Williams, Stephen; McCabe, Edward R B; Maddox, Yvonne T

2011-01-01

A December 2010 meeting, "Down Syndrome: National Conference on Patient Registries, Research Databases, and Biobanks," was jointly sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) at the National Institutes of Health (NIH) in Bethesda, MD, and the Global Down Syndrome Foundation (GDSF)/Linda Crnic Institute for Down Syndrome based in Denver, CO. Approximately 70 attendees and organizers from various advocacy groups, federal agencies (Centers for Disease Control and Prevention, and various NIH Institutes, Centers, and Offices), members of industry, clinicians, and researchers from various academic institutions were greeted by Drs. Yvonne Maddox, Deputy Director of NICHD, and Edward McCabe, Executive Director of the Linda Crnic Institute for Down Syndrome. They charged the participants to focus on the separate issues of contact registries, research databases, and biobanks through both podium presentations and breakout session discussions. Among the breakout groups for each of the major sessions, participants were asked to generate responses to questions posed by the organizers concerning these three research resources as they related to Down syndrome and then to report back to the group at large with a summary of their discussions. This report represents a synthesis of the discussions and suggested approaches formulated by the group as a whole. Copyright © 2011. Published by Elsevier Inc. All rights reserved.

42 CFR 488.115 - Care guidelines.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Care guidelines. 488.115 Section 488.115 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... § 488.115 Care guidelines. EC01JA91.110 EC01JA91.111 EC01JA91.112 EC01JA91.113 EC01JA91.114 EC01JA91.115...

Self-Care in Women with Breast Cancer.

DTIC Science & Technology

1992-01-01

UNIVERSITY OF ARIZONA TUCSON. ASIZO04A iIM VLIIOF MU23110C oO r. Carrie J9 ftadon V Linda S. ?%Ilipo. PM0. IS. rIJ-%# Duireto of 5eseaef Wt.-: fteto 30...117-193). Atlanta, GA: The American Cancer Society Inc. Seligman , M.E.P. (1975). Helplessness: On depression, development, & death. San Francisco, CA...personality factors in the delay of gratification of hemodialysis patients. Journal of Personality and gocial Psycholoq, 51(2), pp. 357-364. Seligman , M.E.P

First Year Morphological Evolution of an Artificial Berm at Fort Myers Beach, Florida

DTIC Science & Technology

2012-01-01

unclassified b. ABSTRACT unclassified c . THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 ERDC/CHL CHETN-II-54...427-2431 or Linda.S.Lillycrop@usace.army.mil. ERDC/CHL CHETN-II-54 January 2012 10 REFERENCES Aidala, J. A., C . E. Burke, and T. N. McLellan...Forum ’91, American Society of Civil Engineers, pp 1234-1239. Allison, M. C ., and C . B. Pollock. 1993. Nearshore Berms: An Evaluation of Prototype

Acute Dermal Irritation Study of Six Jet Fuels in New Zealand White Rabbits: Comparison of Four Bio-Based Jet Fuels with Two Petroleum JP-8 Fuels

DTIC Science & Technology

2014-02-01

NA 5c. PROGRAM ELEMENT NUMBER 62202F 6. AUTHOR(S) Sterner, Teresa R.1; Hurley, Jonathon M.2; Edwards, James T.3; Shafer, Linda M.4; Mattie , David R... Mattie , D.R. 2014. Acute Dermal Irritation Study of Ten Jet Fuels in New Zealand White Rabbits: Comparison of Synthetic and Bio -Based Jet Fuels with...AFRL-RH-WP-TR-2014-0046 ACUTE DERMAL IRRITATION STUDY OF SIX JET FUELS IN NEW ZEALAND WHITE RABBITS: COMPARISON OF FOUR BIO -BASED JET FUELS

Computational Approaches for Predicting Nonlinear Interactions of Chemical Mixtures in Biological Systems

DTIC Science & Technology

2009-12-01

exposure. Feces samples were collected at 24hrs and 48hrs. No fecal matter was present at 6hrs. Urine samples were collected at 6hrs, 24hrs and 48hrs...atmosphere sampling technique (Tremblay et al, in press) to characterize the inhalation exposure chamber for JP-8 and S- 8 exposures at Loma Linda Veterans... samples were collected for 1 min at 400 mL/min and quantified using thermal desorption gas chromatography mass spectrometry (TDS-GC/MS). The method was

Officers and Council, 1998-1999

NASA Astrophysics Data System (ADS)

1999-10-01

The 1998-1999 Council of the British Astronomical Association photographed on the steps of Burlington House, London, on 1999 May 26. Front row, left to right: Bob Marriott, Hazel McGee, Martin Mobberley, Nick James, Jonathan Shanklin, Ron Johnson; centre: Richard Miles, Gordon Taylor, Jacqueline Mitton, David Tucker, John Mason, Pat Barber, David Reid, Peter Hudson; back: Laurence Anslow, Guy Hurst, Lionel Mayling, Nick Hewitt, Owen Brazell, Tony Kinder, Mark Armstrong, Maurice Gavin. Photo by Hazel McGee and Linda Newton.

Command History for 1989.

DTIC Science & Technology

1990-09-01

13 Bart Kuhn, GM-14 Samantha K. Maddox , GS-04 Mike Nakada, GM- 13 John Wolfe, GM-14 Reynaldo I. Monzon, GS- 12 Jose G. Suarez, GS- 11 19 Product...1410-09 GS-334-09 Janice Whiting Procurement Clerk Code 21 GS-1106-05 Separations Samantha Maddox Hoa T. Lu Supply Clerk Computer Specialist Code 21...Jennifer Thorp Royal S. Magnus Student Aide Personnel Research Psychologist Code 23 Code 12 GW-322-03 GS-180-11 Linda L. Turnmire Yvonne S. Baker Computer

Possible role of jasmonic acid in the regulation of floral induction, evocation and floral differentiation in Lemna minor L.

PubMed

Krajncic, B; Kristl, J; Janzekovic, I

2006-01-01

Jasmonic acid (JA) is implicated in a wide variety of developmental and physiological processes in plants. Here, we studied the effects of JA and the combination of JA and ethylenediamine-dio-hydroxyphenyl-acetic acid (EDDHA) on flowering in Lemna minor in axenical cultures. JA (0.475-47.5 nmol l(-1)) enhanced floral induction in L. minor under long-day (LD) conditions. Under the same conditions, at a concentration of 237.5 nmol l(-1), JA inhibited floral induction, and at a concentration of 475 nmol l(-1) it prevented floral induction. Under LD conditions with LD preculture, a combination of EDDHA (20,500 nmol l(-1)) and JA (47.5 nmol l(-1)) had a synergistic effect on the promotion of floral induction. Floral induction was enhanced to the greatest extent in experiments with LD precultures. Microscopic examination of microphotographs of histological sections showed that JA and, to an even greater extent, JA+EDDHA at optimal concentrations promote apical floral induction (evocation). Furthermore, JA, and to an even greater extent JA in combination with EDDHA in an optimal concentration, also promote flower differentiation, especially the development of stamens, as is evident from the microphotographs. The experimental results show that JA promotes floral induction in other species of Lemnaceae from various groups according to their photoperiodic response. The results support our hypothesis that, in addition to previously ascribed functions, JA may regulate floral induction, evocation and floral differentiation. Our hypothesis is supported also by the results obtained by quantitative determination of endogenous JA levels in L. minor at three growth stages. The levels of endogenous JA decreased from 389 ng JA g(-1) (fresh weight) of L. minor during the vegetative stage to 217 ng JA g(-1) during the evocation stage, and to 37.5 ng JA g(-1) during the flowering stage, which proves that JA is used for flowering.

Jasmonic acid-isoleucine formation in grapevine (Vitis vinifera L.) by two enzymes with distinct transcription profiles.

PubMed

Böttcher, Christine; Burbidge, Crista A; di Rienzo, Valentina; Boss, Paul K; Davies, Christopher

2015-07-01

The plant hormone jasmonic acid (JA) is essential for stress responses and the formation of reproductive organs, but its role in fruit development and ripening is unclear. Conjugation of JA to isoleucine is a crucial step in the JA signaling pathway since only JA-Ile is recognized by the jasmonate receptor. The conjugation reaction is catalyzed by JA-amido synthetases, belonging to the family of Gretchen Hagen3 (GH3) proteins. Here, in vitro studies of two grapevine (Vitis vinifera L. cv Shiraz) GH3 enzymes, VvGH3-7 and VvGH3-9, demonstrated JA-conjugating activities with an overlapping range of amino acid substrates, including isoleucine. Expression studies of the corresponding genes in grape berries combined with JA and JA-Ile measurements suggested a primary role for JA signaling in fruit set and cell division and did not support an involvement of JA in the ripening process. In response to methyl JA (MeJA) treatment, and in wounded and unwounded (distal) leaves, VvGH3-9 transcripts accumulated, indicating a participation in the JA response. In contrast, VvGH3-7 was unresponsive to MeJA and local wounding, demonstrating a differential transcriptional regulation of VvGH3-7 and VvGH3-9. The transient induction of VvGH3-7 in unwounded, distal leaves was suggestive of the involvement of an unknown mobile wound signal. © 2014 Institute of Botany, Chinese Academy of Sciences.

Disentangling the initiation from the response in joint attention: an eye-tracking study in toddlers with autism spectrum disorders.

PubMed

Billeci, L; Narzisi, A; Campatelli, G; Crifaci, G; Calderoni, S; Gagliano, A; Calzone, C; Colombi, C; Pioggia, G; Muratori, F

2016-05-17

Joint attention (JA), whose deficit is an early risk marker for autism spectrum disorder (ASD), has two dimensions: (1) responding to JA and (2) initiating JA. Eye-tracking technology has largely been used to investigate responding JA, but rarely to study initiating JA especially in young children with ASD. The aim of this study was to describe the differences in the visual patterns of toddlers with ASD and those with typical development (TD) during both responding JA and initiating JA tasks. Eye-tracking technology was used to monitor the gaze of 17 children with ASD and 15 age-matched children with TD during the presentation of short video sequences involving one responding JA and two initiating JA tasks (initiating JA-1 and initiating JA-2). Gaze accuracy, transitions and fixations were analyzed. No differences were found in the responding JA task between children with ASD and those with TD, whereas, in the initiating JA tasks, different patterns of fixation and transitions were shown between the groups. These results suggest that children with ASD and those with TD show different visual patterns when they are expected to initiate joint attention but not when they respond to joint attention. We hypothesized that differences in transitions and fixations are linked to ASD impairments in visual disengagement from face, in global scanning of the scene and in the ability to anticipate object's action.

Mapping methyl jasmonate-mediated transcriptional reprogramming of metabolism and cell cycle progression in cultured Arabidopsis cells

PubMed Central

Pauwels, Laurens; Morreel, Kris; De Witte, Emilie; Lammertyn, Freya; Van Montagu, Marc; Boerjan, Wout; Inzé, Dirk; Goossens, Alain

2008-01-01

Jasmonates (JAs) are plant-specific signaling molecules that steer a diverse set of physiological and developmental processes. Pathogen attack and wounding inflicted by herbivores induce the biosynthesis of these hormones, triggering defense responses both locally and systemically. We report on alterations in the transcriptome of a fast-dividing cell culture of the model plant Arabidopsis thaliana after exogenous application of methyl JA (MeJA). Early MeJA response genes encoded the JA biosynthesis pathway proteins and key regulators of MeJA responses, including most JA ZIM domain proteins and MYC2, together with transcriptional regulators with potential, but yet unknown, functions in MeJA signaling. In a second transcriptional wave, MeJA reprogrammed cellular metabolism and cell cycle progression. Up-regulation of the monolignol biosynthesis gene set resulted in an increased production of monolignols and oligolignols, the building blocks of lignin. Simultaneously, MeJA repressed activation of M-phase genes, arresting the cell cycle in G2. MeJA-responsive transcription factors were screened for their involvement in early signaling events, in particular the regulation of JA biosynthesis. Parallel screens based on yeast one-hybrid and transient transactivation assays identified both positive (MYC2 and the AP2/ERF factor ORA47) and negative (the C2H2 Zn finger proteins STZ/ZAT10 and AZF2) regulators, revealing a complex control of the JA autoregulatory loop and possibly other MeJA-mediated downstream processes. PMID:18216250

Unclassified Publications of Lincoln Laboratory 1 January - 31 December 1997. Volume 23.

DTIC Science & Technology

1997-12-31

ADA333490 7497 Nonconventional 3D Imaging Shirley, L.G. Line. Lab. J., Vol. 9, Using Wavelength-Dependent Hallerman , G.R. No. 2, 1996...11883 11905A 11941 A Comparison of Surface Contour Measurements Based on Speckle Pattern Sampling and Coordinate Measuring Machines Hallerman , G.R...Halbritter, J., MS-11729 Hall, K.L., JA-7354, JA-7367, JA-7462, JA-7477, MS-11776A, MS-12227, MS-12409 Haller, E.E., JA-7433 Hallerman , G.R., JA

Induced plant-defenses suppress herbivore reproduction but also constrain predation of their offspring.

PubMed

Ataide, Livia M S; Pappas, Maria L; Schimmel, Bernardus C J; Lopez-Orenes, Antonio; Alba, Juan M; Duarte, Marcus V A; Pallini, Angelo; Schuurink, Robert C; Kant, Merijn R

2016-11-01

Inducible anti-herbivore defenses in plants are predominantly regulated by jasmonic acid (JA). On tomato plants, most genotypes of the herbivorous generalist spider mite Tetranychus urticae induce JA defenses and perform poorly on it, whereas the Solanaceae specialist Tetranychus evansi, who suppresses JA defenses, performs well on it. We asked to which extent these spider mites and the predatory mite Phytoseiulus longipes preying on these spider mites eggs are affected by induced JA-defenses. By artificially inducing the JA-response of the tomato JA-biosynthesis mutant def-1 using exogenous JA and isoleucine (Ile), we first established the relationship between endogenous JA-Ile-levels and the reproductive performance of spider mites. For both mite species we observed that they produced more eggs when levels of JA-Ile were low. Subsequently, we allowed predatory mites to prey on spider mite-eggs derived from wild-type tomato plants, def-1 and JA-Ile-treated def-1 and observed that they preferred, and consumed more, eggs produced on tomato plants with weak JA defenses. However, predatory mite oviposition was similar across treatments. Our results show that induced JA-responses negatively affect spider mite performance, but positively affect the survival of their offspring by constraining egg-predation. Copyright © 2016 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

Go for EVA!

NASA Technical Reports Server (NTRS)

1995-01-01

In this educational video series, 'Liftoff to Learning', astronauts from the STS-37 Space Shuttle Mission (Jay Apt, Jerry Ross, Ken Cameron, Steve Nagel, and Linda Godwin) show what EVA (extravehicular activity) means, talk about the history and design of the space suits and why they are designed the way they are, describe different ways they are used (payload work, testing and maintenance of equipment, space environment experiments) in EVA work, and briefly discuss the future applications of the space suits. Computer graphics and animation is included.

Landing of STS-59 Endeavour, OV-105, at Edwards Air Force Base

NASA Image and Video Library

1999-04-20

STS059-S-108 (20 April 1994) --- The main landing gear of the Space Shuttle Endeavour touches down at Edwards Air Force Base to complete the 11-day STS-59/SRL-1 mission. Landing occurred at 9:54 a.m. (PDT), April 20, 1994. Mission duration was 11 days, 5 hours, 49 minutes. Guiding Endeavour to a landing was astronaut Sidney M. Gutierrez, STS-59 commander. His crew was Kevin P. Chilton, Linda M. Godwin, Jerome (Jay) Apt, Michael R. (Rich) Clifford and Thomas D. Jones.

Landing of STS-59 Shuttle Endeavour at Edwards Air Force Base

NASA Image and Video Library

1994-04-20

STS059-S-107 (20 April 1994) --- The main landing gear of the Space Shuttle Endeavour touches down at Edwards Air Force Base to complete the 11-day STS-59/SRL-1 mission. Landing occurred at 9:54 a.m. (PDT), April 20, 1994. Mission duration was 11 days, 5 hours, 49 minutes. Guiding Endeavour to a landing was astronaut Sidney M. Gutierrez, STS-59 commander. His crew was Kevin P. Chilton, Linda M. Godwin, Jerome (Jay) Apt, Michael R. (Rich) Clifford and Thomas D. Jones.

MARS PATHFINDER LANDER REMOVED FROM SHIPPING CONTAINER IN SAEF-2

NASA Technical Reports Server (NTRS)

1996-01-01

In the SAEF-2 spacecraft checkout facility at Kennedy Space Center, engineers and technicians from Jet Propulsion Laboratory remove the Mars Pathfinder lander from its shipping container, still covered in protective wrapping. Pictured from L-R, Linda Robeck, Jerry Gutierrez, Lorraine Garcia, Chuck Foehlinger of JPL. The arrival of the spacecraft at KSC from Pasadena, CA occurred on Aug. 13, 1996. Launch of Mars Pathfinder aboard a McDonnell Douglas Delta II rocket will occur from Pad B at Complex 17 on Dec. 2.

The technical editing internship: What makes it work

DOE Office of Scientific and Technical Information (OSTI.GOV)

Caruthers, C.M.; Caruthers, L.E.; Schmidt, B.J.

1988-01-01

The following paper presents the experiences and perceptions of the three main participants of a technical editing internship at Argonne National Laboratory during the summer of 1986. Linda Caruthers, Clifford Caruthers, and Bryan Schmidt/emdash/teacher, supervisor, and intern, respectively/emdash/share what they received as their roles and responsibilities in guiding, managing, and becoming an entry-level technical editor. The following discussions demonstrate how the efforts of three people pursuing different objectives achieve the primary goal of all technical writers and editors: high-quality publications.

Stennis cuts ribbon on records retention facility

NASA Image and Video Library

2010-08-24

NASA's John C. Stennis Space Center cut the ribbon Aug. 24 on a new, storm-resistant Records Retention Facility that consolidates and protects records storage at the nation's premier rocket engine test facility. This facility will also house history office operations. Participants in the ribbon-cutting included: (l to r) Gay Irby, Center Operations deputy director at Stennis; Linda Cureton, NASA chief information officer; Patrick Scheuermann, Stennis director; Jane Odom, NASA chief archivist; Dinna Cottrell, Stennis chief information officer; and James Cluff, Stennis records manager.

Nutrition Knowledge in the U.S. Navy

DTIC Science & Technology

1990-12-31

rAD-A232 085]Y( NUTRITION KNOWLEDGE IN THE U.S. NAVY L. K. TRENT kI DT|C-A91" AfELECTEj •,bMAR 1 ~ REPORT No. 90-27 Approved for public release...BETHESDA, MARYLAND 91 3 11 034 NUTRITION KNOWLEDGE IN THE U. S. NAVY Linda Kelly Trent Health Services Research Department Naval Health Research Center P.O...implicating diet in the etiology of disease continues to mount, national organizations have launched nutrition education campaigns intended to guide the

Complementary action of jasmonic acid on salicylic acid in mediating fungal elicitor-induced flavonol glycoside accumulation of Ginkgo biloba cells.

PubMed

Xu, Maojun; Dong, Jufang; Wang, Huizhong; Huang, Luqi

2009-08-01

The antagonistic action between jasmonic acid (JA) and salicylic acid (SA) in plant defence responses has been well documented. However, their relationship in secondary metabolite production is largely unknown. Here, we report that PB90, a protein elicitor from Phytophthora boehmeriae, triggers JA generation, SA accumulation and flavonol glycoside production of Ginkgo biloba cells. JA inhibitors suppress not only PB90-triggered JA generation, but also the elicitor-induced flavonol glycoside production. However, the elicitor can still enhance flavonol glycoside production even though the JA generation is totally inhibited. Over-expression of SA hydrolase gene NahG not only abolishes SA accumulation, but also suppresses the elicitor-induced flavonol glycoside production when JA signalling is inhibited. Interestingly, expression of NahG does not inhibit the elicitor-induced flavonol glycoside accumulation in the absence of JA inhibitors. Moreover, JA levels are significantly enhanced when SA accumulation is impaired in the transgenic cells. Together, the data suggest that both JA and SA are involved in PB90-induced flavonol glycoside production. Furthermore, we demonstrate that JA signalling might be enhanced to substitute for SA to mediate the elicitor-induced flavonol glycoside accumulation when SA signalling is impaired, which reveals an unusual complementary relationship between JA and SA in mediating plant secondary metabolite production.

Role of jasmonic acid in improving tolerance of rapeseed (Brassica napus L.) to Cd toxicity*

PubMed Central

Ali, Essa; Hussain, Nazim; Shamsi, Imran Haider; Jabeen, Zahra; Siddiqui, Muzammil Hussain; Jiang, Li-xi

2018-01-01

The well-known detrimental effects of cadmium (Cd) on plants are chloroplast destruction, photosynthetic pigment inhibition, imbalance of essential plant nutrients, and membrane damage. Jasmonic acid (JA) is an alleviator against different stresses such as salinity and drought. However, the functional attributes of JA in plants such as the interactive effects of JA application and Cd on rapeseed in response to heavy metal stress remain unclear. JA at 50 μmol/L was observed in literature to have senescence effects in plants. In the present study, 25 μmol/L JA is observed to be a “stress ameliorating molecule” by improving the tolerance of rapeseed plants to Cd toxicity. JA reduces the Cd uptake in the leaves, thereby reducing membrane damage and malondialdehyde content and increasing the essential nutrient uptake. Furthermore, JA shields the chloroplast against the damaging effects of Cd, thereby increasing gas exchange and photosynthetic pigments. Moreover, JA modulates the antioxidant enzyme activity to strengthen the internal defense system. Our results demonstrate the function of JA in alleviating Cd toxicity and its underlying mechanism. Moreover, JA attenuates the damage of Cd to plants. This study enriches our knowledge regarding the use of and protection provided by JA in Cd stress. PMID:29405041

Look into my eyes: Investigating joint attention using interactive eye-tracking and fMRI in a developmental sample.

PubMed

Oberwelland, E; Schilbach, L; Barisic, I; Krall, S C; Vogeley, K; Fink, G R; Herpertz-Dahlmann, B; Konrad, K; Schulte-Rüther, M

2016-04-15

Joint attention, the shared attentional focus of at least two people on a third significant object, is one of the earliest steps in social development and an essential aspect of reciprocal interaction. However, the neural basis of joint attention (JA) in the course of development is completely unknown. The present study made use of an interactive eye-tracking paradigm in order to examine the developmental trajectories of JA and the influence of a familiar interaction partner during the social encounter. Our results show that across children and adolescents JA elicits a similar network of "social brain" areas as well as attention and motor control associated areas as in adults. While other-initiated JA particularly recruited visual, attention and social processing areas, self-initiated JA specifically activated areas related to social cognition, decision-making, emotions and motivational/reward processes highlighting the rewarding character of self-initiated JA. Activation was further enhanced during self-initiated JA with a familiar interaction partner. With respect to developmental effects, activation of the precuneus declined from childhood to adolescence and additionally shifted from a general involvement in JA towards a more specific involvement for self-initiated JA. Similarly, the temporoparietal junction (TPJ) was broadly involved in JA in children and more specialized for self-initiated JA in adolescents. Taken together, this study provides first-time data on the developmental trajectories of JA and the effect of a familiar interaction partner incorporating the interactive character of JA, its reciprocity and motivational aspects. Copyright © 2016 Elsevier Inc. All rights reserved.

Development of marker genes for jasmonic acid signaling in shoots and roots of wheat

PubMed Central

Liu, Hongwei; Carvalhais, Lilia Costa; Kazan, Kemal; Schenk, Peer M.

2016-01-01

ABSTRACT The jasmonic acid (JA) signaling pathway plays key roles in a diverse array of plant development, reproduction, and responses to biotic and abiotic stresses. Most of our understanding of the JA signaling pathway derives from the dicot model plant Arabidopsis thaliana, while corresponding knowledge in wheat is somewhat limited. In this study, the expression of 41 genes implicated in the JA signaling pathway has been assessed on 10 day-old bread wheat seedlings, 24 h, 48 h, and 72 h after methyl-jasmonate (MeJA) treatment using quantitative real-time PCR. The examined genes have been previously reported to be involved in JA biosynthesis and catabolism, JA perception and signaling, and pathogen defense in wheat shoots and roots. This study provides evidence to suggest that the effect of MeJA treatment is more prominent in shoots than roots of wheat seedlings, and substantial regulation of the JA pathway-dependent defense genes occurs at 72 h after MeJA treatment. Results show that the expression of 22 genes was significantly affected by MeJA treatment in wheat shoots. However, only PR1.1 and PR3 were significantly differentially expressed in wheat roots, both at 24 h post-MeJA treatment, with other genes showing large variation in their gene expression in roots. While providing marker genes on JA signaling in wheat, future work may focus on elucidating the regulatory function of JA-modulated transcription factors, some of which have well-studied potential orthologs in Arabidopsis. PMID:27115051

Salicylic acid and jasmonic acid are essential for systemic resistance against tobacco mosaic virus in Nicotiana benthamiana.

PubMed

Zhu, Feng; Xi, De-Hui; Yuan, Shu; Xu, Fei; Zhang, Da-Wei; Lin, Hong-Hui

2014-06-01

Systemic resistance is induced by pathogens and confers protection against a broad range of pathogens. Recent studies have indicated that salicylic acid (SA) derivative methyl salicylate (MeSA) serves as a long-distance phloem-mobile systemic resistance signal in tobacco, Arabidopsis, and potato. However, other experiments indicate that jasmonic acid (JA) is a critical mobile signal. Here, we present evidence suggesting both MeSA and methyl jasmonate (MeJA) are essential for systemic resistance against Tobacco mosaic virus (TMV), possibly acting as the initiating signals for systemic resistance. Foliar application of JA followed by SA triggered the strongest systemic resistance against TMV. Furthermore, we use a virus-induced gene-silencing-based genetics approach to investigate the function of JA and SA biosynthesis or signaling genes in systemic response against TMV infection. Silencing of SA or JA biosynthetic and signaling genes in Nicotiana benthamiana plants increased susceptibility to TMV. Genetic experiments also proved the irreplaceable roles of MeSA and MeJA in systemic resistance response. Systemic resistance was compromised when SA methyl transferase or JA carboxyl methyltransferase, which are required for MeSA and MeJA formation, respectively, were silenced. Moreover, high-performance liquid chromatography-mass spectrometry analysis indicated that JA and MeJA accumulated in phloem exudates of leaves at early stages and SA and MeSA accumulated at later stages, after TMV infection. Our data also indicated that JA and MeJA could regulate MeSA and SA production. Taken together, our results demonstrate that (Me)JA and (Me)SA are required for systemic resistance response against TMV.

17 CFR Appendix 1 to Part 45 - Tables of Minimum Primary Economic Terms Data

Code of Federal Regulations, 2012 CFR

2012-04-01

... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Tables of Minimum Primary Economic Terms Data 1 Appendix 1 to Part 45 Commodity and Securities Exchanges COMMODITY FUTURES TRADING... Minimum Primary Economic Terms Data ER13JA12.003 ER13JA12.004 ER13JA12.005 ER13JA12.006 ER13JA12.007...

17 CFR Appendix 1 to Part 45 - Tables of Minimum Primary Economic Terms Data

Code of Federal Regulations, 2013 CFR

2013-04-01

... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Tables of Minimum Primary Economic Terms Data 1 Appendix 1 to Part 45 Commodity and Securities Exchanges COMMODITY FUTURES TRADING... Minimum Primary Economic Terms Data ER13JA12.003 ER13JA12.004 ER13JA12.005 ER13JA12.006 ER13JA12.007...

Jasmonic acid carboxyl methyltransferase regulates development and herbivory-induced defense response in rice.

PubMed

Qi, Jinfeng; Li, Jiancai; Han, Xiu; Li, Ran; Wu, Jianqiang; Yu, Haixin; Hu, Lingfei; Xiao, Yutao; Lu, Jing; Lou, Yonggen

2016-06-01

Jasmonic acid (JA) and related metabolites play a key role in plant defense and growth. JA carboxyl methyltransferase (JMT) may be involved in plant defense and development by methylating JA to methyl jasmonate (MeJA) and thus influencing the concentrations of JA and related metabolites. However, no JMT gene has been well characterized in monocotyledon defense and development at the molecular level. After we cloned a rice JMT gene, OsJMT1, whose encoding protein was localized in the cytosol, we found that the recombinant OsJMT1 protein catalyzed JA to MeJA. OsJMT1 is up-regulated in response to infestation with the brown planthopper (BPH; Nilaparvata lugens). Plants in which OsJMT1 had been overexpressed (oe-JMT plants) showed reduced height and yield. These oe-JMT plants also exhibited increased MeJA levels but reduced levels of herbivore-induced JA and jasmonoyl-isoleucine (JA-Ile). The oe-JMT plants were more attractive to BPH female adults but showed increased resistance to BPH nymphs, probably owing to the different responses of BPH female adults and nymphs to the changes in levels of H2 O2 and MeJA in oe-JMT plants. These results indicate that OsJMT1, by altering levels of JA and related metabolites, plays a role in regulating plant development and herbivore-induced defense responses in rice. © 2015 Institute of Botany, Chinese Academy of Sciences.

The relationship between joint attention and theory of mind in neurotypical adults.

PubMed

Shaw, Jordan A; Bryant, Lauren K; Malle, Bertram F; Povinelli, Daniel J; Pruett, John R

2017-05-01

Joint attention (JA) is hypothesized to have a close relationship with developing theory of mind (ToM) capabilities. We tested the co-occurrence of ToM and JA in social interactions between adults with no reported history of psychiatric illness or neurodevelopmental disorders. Participants engaged in an experimental task that encouraged nonverbal communication, including JA, and also ToM activity. We adapted an in-lab variant of experience sampling methods (Bryant et al., 2013) to measure ToM during JA based on participants' subjective reports of their thoughts while performing the task. This experiment successfully elicited instances of JA in 17/20 dyads. We compared participants' thought contents during episodes of JA and non-JA. Our results suggest that, in adults, JA and ToM may occur independently. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Adverse Childhood Experiences among a Community of Resilient Centenarians and Seniors: Implications for a Chronic Disease Prevention Framework.

PubMed

Spencer-Hwang, Rhonda; Torres, Xochitl; Valladares, Johanny; Pasco-Rubio, Marco; Dougherty, Molly; Kim, Wonha

2018-03-11

Research has linked adverse childhood experiences (ACEs) with chronic disease in adults and diminished life span. Adverse biological embedding of ACEs potentially occurs through inflammatory mechanisms; inflammatory marker alterations are identified as candidate biomarkers for mediating health consequences. Lifestyle practices of residents of California's Loma Linda Blue Zone, one of five worldwide longevity hotspots, may provide insight into inflammation remediation and chronic disease prevention. Little research has been done on centenarians' early-life experiences or on ACEs in a longevity community. To interview centenarians and seniors in this region regarding their childhood experiences to inform chronic disease prevention frameworks. Qualitative study of Loma Linda Blue Zone community members. Childhood exposures and practices were assessed using focus groups and semistructured key informant interviews, with open-ended questions on general hardships and ACEs and supplemented with lifestyle and resiliency factor questions. Data were audiorecorded and transcribed. Integrative grounded theory methods guided coding and theming. Exposure to ACEs and practice of resiliency factors. Participants (7 centenarians and 29 seniors) reported exposure to multiple ACEs (domains: Economic deprivation, family dysfunction, and community violence). Community members reported practicing resiliency factors, each with anti-inflammatory properties suggesting mitigation of ACE-related toxic stress. This is one of the first studies of its kind to identify a community of resilient members despite their tremendous burden of ACEs. Embedding the identified resiliency factors into chronic disease prevention frameworks has potential for mitigating systemic inflammation, alleviating chronic disease burden, and promoting a culture of health.

A school-wide assessment of social media usage by students in a US dental school.

PubMed

Arnett, M R; Christensen, H L; Nelson, B A

2014-11-01

Social media sites have become an established means of communication due to the exponential growth in number of users across the world and the encouragement of interaction between users through site features. The purpose of this study was to determine the extent to which Loma Linda University School of Dentistry students use social media accounts, the types of accounts they prefer, their interest in incorporating social media into courses and their perceptions of the usefulness of social media in private practice. In addition, we wanted to determine the degree of student interest in the integration of these social tools into their instruction. One thousand one hundred and sixty-two students from Loma Linda University School of Dentistry were invited by e-mail to complete a confidential 18 item multiple choice survey through Surveymonkey.com. The overall response rate was 30% (n = 351) from the pooled response periods; the first in 2011 and the second in 2013. Similar to other studies, Facebook was used by 91% of the School of Dentistry students, and less than half used Google+, Twitter and LinkedIn. Of the respondents, 68% of students reported communicating on social media daily and 80% saw value for practising dentists to operate accounts. Time and privacy concerns were the largest barriers to usage at 16% and 12% respectively. One third of respondents were in favour of the incorporation of social media in their courses.

Genome-wide association study reveals novel players in defense hormone crosstalk in Arabidopsis.

PubMed

Proietti, Silvia; Caarls, Lotte; Coolen, Silvia; Van Pelt, Johan A; Van Wees, Saskia C M; Pieterse, Corné M J

2018-05-31

Jasmonic acid (JA) regulates plant defenses against necrotrophic pathogens and insect herbivores. Salicylic acid (SA) and abscisic acid (ABA) can antagonize JA-regulated defenses, thereby modulating pathogen or insect resistance. We performed a genome-wide association (GWA) study on natural genetic variation in Arabidopsis thaliana for the effect of SA and ABA on the JA pathway. We treated 349 Arabidopsis accessions with methyl JA (MeJA), or a combination of MeJA and either SA or ABA, after which expression of the JA-responsive marker gene PDF1.2 was quantified as a readout for GWA analysis. Both hormones antagonized MeJA-induced PDF1.2 in the majority of the accessions, but with a large variation in magnitude. GWA mapping of the SA- and ABA-affected PDF1.2 expression data revealed loci associated with crosstalk. GLYI4 (encoding a glyoxalase) and ARR11 (encoding an Arabidopsis response regulator involved in cytokinin signaling) were confirmed by T-DNA insertion mutant analysis to affect SA-JA crosstalk and resistance against the necrotroph Botrytis cinerea. In addition, At1g16310 (encoding a cation efflux family protein) was confirmed to affect ABA-JA crosstalk and susceptibility to Mamestra brassicae herbivory. Collectively, this GWA study identified novel players in JA hormone crosstalk with potential roles in the regulation of pathogen or insect resistance. This article is protected by copyright. All rights reserved.

Jasmonate and Phytochrome A Signaling in Arabidopsis Wound and Shade Responses Are Integrated through JAZ1 Stability[C][W

PubMed Central

Robson, Frances; Okamoto, Haruko; Patrick, Elaine; Harris, Sue-Ré; Wasternack, Claus; Brearley, Charles; Turner, John G.

2010-01-01

Jasmonate (JA) activates plant defense, promotes pollen maturation, and suppresses plant growth. An emerging theme in JA biology is its involvement in light responses; here, we examine the interdependence of the JA- and light-signaling pathways in Arabidopsis thaliana. We demonstrate that mutants deficient in JA biosynthesis and signaling are deficient in a subset of high irradiance responses in far-red (FR) light. These mutants display exaggerated shade responses to low, but not high, R/FR ratio light, suggesting a role for JA in phytochrome A (phyA) signaling. Additionally, we demonstrate that the FR light–induced expression of transcription factor genes is dependent on CORONATINE INSENSITIVE1 (COI1), a central component of JA signaling, and is suppressed by JA. phyA mutants had reduced JA-regulated growth inhibition and VSP expression and increased content of cis-(+)-12-oxophytodienoic acid, an intermediate in JA biosynthesis. Significantly, COI1-mediated degradation of JASMONATE ZIM DOMAIN1-β-glucuronidase (JAZ1-GUS) in response to mechanical wounding and JA treatment required phyA, and ectopic expression of JAZ1-GUS resulted in exaggerated shade responses. Together, these results indicate that JA and phyA signaling are integrated through degradation of the JAZ1 protein, and both are required for plant responses to light and stress. PMID:20435902

Ethylene signaling renders the jasmonate response of Arabidopsis insensitive to future suppression by salicylic Acid.

PubMed

Leon-Reyes, Antonio; Du, Yujuan; Koornneef, Annemart; Proietti, Silvia; Körbes, Ana P; Memelink, Johan; Pieterse, Corné M J; Ritsema, Tita

2010-02-01

Cross-talk between jasmonate (JA), ethylene (ET), and Salicylic acid (SA) signaling is thought to operate as a mechanism to fine-tune induced defenses that are activated in response to multiple attackers. Here, 43 Arabidopsis genotypes impaired in hormone signaling or defense-related processes were screened for their ability to express SA-mediated suppression of JA-responsive gene expression. Mutant cev1, which displays constitutive expression of JA and ET responses, appeared to be insensitive to SA-mediated suppression of the JA-responsive marker genes PDF1.2 and VSP2. Accordingly, strong activation of JA and ET responses by the necrotrophic pathogens Botrytis cinerea and Alternaria brassicicola prior to SA treatment counteracted the ability of SA to suppress the JA response. Pharmacological assays, mutant analysis, and studies with the ET-signaling inhibitor 1-methylcyclopropene revealed that ET signaling renders the JA response insensitive to subsequent suppression by SA. The APETALA2/ETHYLENE RESPONSE FACTOR transcription factor ORA59, which regulates JA/ET-responsive genes such as PDF1.2, emerged as a potential mediator in this process. Collectively, our results point to a model in which simultaneous induction of the JA and ET pathway renders the plant insensitive to future SA-mediated suppression of JA-dependent defenses, which may prioritize the JA/ET pathway over the SA pathway during multi-attacker interactions.

Identification of jasmonic acid and its methyl ester as gum-inducing factors in tulips.

PubMed

Skrzypek, Edyta; Miyamoto, Kensuke; Saniewski, Marian; Ueda, Junichi

2005-02-01

The purpose of this study was to identify endogenous factors that induce gummosis and to show their role in gummosis in tulip (Tulipa gesneriana L. cv. Apeldoorn) stems. Using procedures to detect endogenous factors that induce gum in the stem of tulips, jasmonic acid (JA) and methyl jasmonate (JA-Me) were successfully identified using gas-liquid chromatography-mass spectrometry. Total amounts of JA and JA-Me designated as jasmonates in tulip stems were also estimated at about 70-80 ng/g fresh weight, using deuterium-labeled jasmonates as internal standards. The application of JA and JA-Me as lanolin pastes substantially induced gums in tulip stems with ethylene production. The application of ethephon, an ethylene-generating compound, however, induced no gummosis although it slightly affected jasmonate content in tulip stems. These results strongly suggest that JA and JA-Me are endogenous factors that induce gummosis in tulip stems.

KSC-01PP1663

NASA Image and Video Library

2001-11-07

KENNEDY SPACE CENTER, Fla. -- STS-108 Mission Specialist Linda A. Godwin is ready to take her turn driving an M-113 armored personnel carrier. She and other crew members are taking part in Terminal Countdown Demonstration Test activities, which include emergency exit from the launch pad and a simulated launch countdown. The 11-day mission will carry the replacement Expedition 4 crew to the International Space Station, as well as the Multi-Purpose Logistics Module Raffaello, filled with supplies and equipment. STS-108 is scheduled to launch Nov. 29 on Space Shuttle Endeavour

Space Shuttle Projects

NASA Image and Video Library

1991-04-05

Launched aboard the Space Shuttle Atlantis on April 5, 1991 at 9:22:44am (EST), the STS-37 mission hurtles toward space. Her crew included Steven R. Nagel, commander; Kenneth D. (Ken) Cameron, pilot; and Jay Apt, Jerry L. Ross, and Linda M. Godwin, all mission specialists. The crew’s major objective was the deployment of the Gamma Ray Observatory (GRO). Included in the observatory were the Burst and Transient Source Experiment (BATSE); the Imaging Compton Telescope (COMPTEL); the Energetic Gamma Ray Experiment Telescope (EGRET); and the Oriented Scintillation Spectrometer Telescope (OSSEE).

Independent Review of the Defense Logistics Agencys Roles and Missions

DTIC Science & Technology

2014-12-01

3,000 3,500 C-5 F-15 C-130 KC-135 B-1 B-52 E-3 N IIN / N SN s BoM Items Ordered BoM Items Not Ordered Orders Not on BoM Warner- Robbins ALC Tinker... Tony Poleo Fred Pribble Michael Scott BG Steven Shapiro Brig Gen Giovanni Tuck Col Rex Adee Linda Barnett Matthew Beebe CDR Tim Benesh COL...DeVincentis Lt Gen (Ret) Kathleen Gainey RADM (Ret) Mark Heinrich CAPT (Ret) Stuart Jones Eric Peltz Marc Robbins This page is intentionally blank

Embryo-Specific Gene Expression in Microspore-Derived Embryos of Brassica napus. An Interaction between Abscisic Acid and Jasmonic Acid1, 2

PubMed Central

Hays, Dirk B.; Wilen, Ronald W.; Sheng, Chuxing; Moloney, Maurice M.; Pharis, Richard P.

1999-01-01

The induction of napin and oleosin gene expression in Brassica napus microspore-derived embryos (MDEs) was studied to assess the possible interaction between abscisic acid (ABA) and jasmonic acid (JA). Napin and oleosin transcripts were detected sooner following treatment with ABA than JA. Treatment of MDEs with ABA plus JA gave an additive accumulation of both napin and oleosin mRNA, the absolute amount being dependent on the concentration of each hormone. Endogenous ABA levels were reduced by 10-fold after treatment with JA, negating the possibility that the observed additive interaction was due to JA-induced ABA biosynthesis. Also, JA did not significantly increase the uptake of [3H-ABA] from the medium into MDEs. This suggests that the additive interaction was not due to an enhanced carrier-mediated ABA uptake by JA. Finally, when JA was added to MDEs that had been treated with the ABA biosynthesis inhibitor fluridone, napin mRNA did not increase. Based on these results with the MDE system, it is possible that embryos of B. napus use endogenous JA to modulate ABA effects on expression of both napin and oleosin. In addition, JA could play a causal role in the reduction of ABA that occurs during late stages of seed development. PMID:10069845

CYP94-mediated jasmonoyl-isoleucine hormone oxidation shapes jasmonate profiles and attenuates defence responses to Botrytis cinerea infection

PubMed Central

Aubert, Yann; Widemann, Emilie; Miesch, Laurence; Pinot, Franck; Heitz, Thierry

2015-01-01

Induced resistance to the necrotrophic pathogen Botrytis cinerea depends on jasmonate metabolism and signalling in Arabidopsis. We have presented here extensive jasmonate profiling in this pathosystem and investigated the impact of the recently reported jasmonoyl-isoleucine (JA-Ile) catabolic pathway mediated by cytochrome P450 (CYP94) enzymes. Using a series of mutant and overexpressing (OE) plant lines, we showed that CYP94B3 and CYP94C1 are integral components of the fungus-induced jasmonate metabolic pathway and control the abundance of oxidized conjugated but also some unconjugated derivatives, such as sulfated 12-HSO4-JA. Despite causing JA-Ile overaccumulation due to impaired oxidation, CYP94 deficiency had negligible impacts on resistance, associated with enhanced JAZ repressor transcript levels. In contrast, plants overexpressing (OE) CYP94B3 or CYP94C1 were enriched in 12-OH-JA-Ile or 12-COOH-JA-Ile respectively. This shift towards oxidized JA-Ile derivatives was concomitant with strongly impaired defence gene induction and reduced disease resistance. CYP94B3-OE, but unexpectedly not CYP94C1-OE, plants displayed reduced JA-Ile levels compared with the wild type, suggesting that increased susceptibility in CYP94C1-OE plants may result from changes in the hormone oxidation ratio rather than absolute changes in JA-Ile levels. Consistently, while feeding JA-Ile to seedlings triggered strong induction of JA pathway genes, induction was largely reduced or abolished after feeding with the CYP94 products 12-OH-JA-Ile and 12-COOH-JA-Ile, respectively. This trend paralleled in vitro pull-down assays where 12-COOH-JA-Ile was unable to promote COI1–JAZ9 co-receptor assembly. Our results highlight the dual function of CYP94B3/C1 in antimicrobial defence: by controlling hormone oxidation status for signal attenuation, these enzymes also define JA-Ile as a metabolic hub directing jasmonate profile complexity. PMID:25903915

Assessing the Role of ETHYLENE RESPONSE FACTOR Transcriptional Repressors in Salicylic Acid-Mediated Suppression of Jasmonic Acid-Responsive Genes.

PubMed

Caarls, Lotte; Van der Does, Dieuwertje; Hickman, Richard; Jansen, Wouter; Verk, Marcel C Van; Proietti, Silvia; Lorenzo, Oscar; Solano, Roberto; Pieterse, Corné M J; Van Wees, Saskia C M

2017-02-01

Salicylic acid (SA) and jasmonic acid (JA) cross-communicate in the plant immune signaling network to finely regulate induced defenses. In Arabidopsis, SA antagonizes many JA-responsive genes, partly by targeting the ETHYLENE RESPONSE FACTOR (ERF)-type transcriptional activator ORA59. Members of the ERF transcription factor family typically bind to GCC-box motifs in the promoters of JA- and ethylene-responsive genes, thereby positively or negatively regulating their expression. The GCC-box motif is sufficient for SA-mediated suppression of JA-responsive gene expression. Here, we investigated whether SA-induced ERF-type transcriptional repressors, which may compete with JA-induced ERF-type activators for binding at the GCC-box, play a role in SA/JA antagonism. We selected ERFs that are transcriptionally induced by SA and/or possess an EAR transcriptional repressor motif. Several of the 16 ERFs tested suppressed JA-dependent gene expression, as revealed by enhanced JA-induced PDF1.2 or VSP2 expression levels in the corresponding erf mutants, while others were involved in activation of these genes. However, SA could antagonize JA-induced PDF1.2 or VSP2 in all erf mutants, suggesting that the tested ERF transcriptional repressors are not required for SA/JA cross-talk. Moreover, a mutant in the co-repressor TOPLESS, that showed reduction in repression of JA signaling, still displayed SA-mediated antagonism of PDF1.2 and VSP2. Collectively, these results suggest that SA-regulated ERF transcriptional repressors are not essential for antagonism of JA-responsive gene expression by SA. We further show that de novo SA-induced protein synthesis is required for suppression of JA-induced PDF1.2, pointing to SA-stimulated production of an as yet unknown protein that suppresses JA-induced transcription. © The Author 2016. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Complete genome analysis of jasmine virus T from Jasminum sambac in China.

PubMed

Tang, Yajun; Gao, Fangluan; Yang, Zhen; Wu, Zujian; Yang, Liang

2016-07-01

The genome of a potyvirus (isolate JaVT_FZ) recovered from jasmine (Jasminum sambac L.) showing yellow ringspot symptoms in Fuzhou, China, was sequenced. JaVT_FZ is closely related to seven other potyviruses with completely sequenced genomes, with which it shares 66-70 % nucleotide and 52-56 % amino acid sequence identity. However, the coat protein (CP) gene shares 82-92 % nucleotide and 90-97 % amino acid sequence identity with those of two partially sequenced potyviruses, named jasmine potyvirus T (JaVT-jasmine) and jasmine yellow mosaic potyvirus (JaYMV-India), respectively. This suggests that JaVT_FZ, JaVT-jasmine and JaYMV-India should be regarded as members of a single potyvirus species, for which the name "Jasmine virus T" has priority.

Unclassified Publications of Lincoln Laboratory, 1 January - 31 December 1990. Volume 16

DTIC Science & Technology

1990-12-31

Apr. 1990 ADA223419 Hopped Communication Systems with Nonuniform Hopping Distributions 880 Bistatic Radar Cross Section of a Fenn, A.J. 2 May1990...EXPERIMENT JA-6241 MS-8424 LUNAR PERTURBATION MAXIMUM LIKELIHOOD ALGORITHM JA-6241 JA-6467 LWIR SPECTRAL BAND MAXIMUM LIKELIHOOD ESTIMATOR JA-6476 MS-8466

Continuously Monocropped Jerusalem Artichoke Changed Soil Bacterial Community Composition and Ammonia-Oxidizing and Denitrifying Bacteria Abundances.

PubMed

Zhou, Xingang; Wang, Zhilin; Jia, Huiting; Li, Li; Wu, Fengzhi

2018-01-01

Soil microbial communities have profound effects on the growth, nutrition and health of plants in agroecosystems. Understanding soil microbial dynamics in cropping systems can assist in determining how agricultural practices influence soil processes mediated by microorganisms. In this study, soil bacterial communities were monitored in a continuously monocropped Jerusalem artichoke (JA) system, in which JA was successively monocropped for 3 years in a wheat field. Soil bacterial community compositions were estimated by amplicon sequencing of the 16S rRNA gene. Abundances of ammonia-oxidizing and denitrifying bacteria were estimated by quantitative PCR analysis of the amoA , nirS , and nirK genes. Results showed that 1-2 years of monocropping of JA did not significantly impact the microbial alpha diversity, and the third cropping of JA decreased the microbial alpha diversity ( P < 0.05). Principal coordinates analysis and permutational multivariate analysis of variance analyses revealed that continuous monocropping of JA changed soil bacterial community structure and function profile ( P < 0.001). At the phylum level, the wheat field was characterized with higher relative abundances of Latescibacteria , Planctomycetes , and Cyanobacteria , the first cropping of JA with Actinobacteria , the second cropping of JA with Acidobacteria , Armatimonadetes , Gemmatimonadetes , and Proteobacteria . At the genus level, the first cropping of JA was enriched with bacterial species with pathogen-antagonistic and/or plant growth promoting potentials, while members of genera that included potential denitrifiers increased in the second and third cropping of JA. The first cropping of JA had higher relative abundances of KO terms related to lignocellulose degradation and phosphorus cycling, the second cropping of JA had higher relative abundances of KO terms nitrous-oxide reductase and nitric-oxide reductase, and the third cropping of JA had higher relative abundances of KO terms

The Recently Identified Isoleucine Conjugate of cis-12-Oxo-Phytodienoic Acid Is Partially Active in cis-12-Oxo-Phytodienoic Acid-Specific Gene Expression of Arabidopsis thaliana

PubMed Central

Floková, Kristýna; Miersch, Otto; Strnad, Miroslav; Novák, Ondřej; Wasternack, Claus; Hause, Bettina

2016-01-01

Oxylipins of the jasmonate family are active as signals in plant responses to biotic and abiotic stresses as well as in development. Jasmonic acid (JA), its precursor cis-12-oxo-phytodienoic acid (OPDA) and the isoleucine conjugate of JA (JA-Ile) are the most prominent members. OPDA and JA-Ile have individual signalling properties in several processes and differ in their pattern of gene expression. JA-Ile, but not OPDA, is perceived by the SCFCOI1-JAZ co-receptor complex. There are, however, numerous processes and genes specifically induced by OPDA. The recently identified OPDA-Ile suggests that OPDA specific responses might be mediated upon formation of OPDA-Ile. Here, we tested OPDA-Ile-induced gene expression in wild type and JA-deficient, JA-insensitive and JA-Ile-deficient mutant background. Tests on putative conversion of OPDA-Ile during treatments revealed only negligible conversion. Expression of two OPDA-inducible genes, GRX480 and ZAT10, by OPDA-Ile could be detected in a JA-independent manner in Arabidopsis seedlings but less in flowering plants. The data suggest a bioactivity in planta of OPDA-Ile. PMID:27611078

Jasmonic acid and salicylic acid activate a common defense system in rice.

PubMed

Tamaoki, Daisuke; Seo, Shigemi; Yamada, Shoko; Kano, Akihito; Miyamoto, Ayumi; Shishido, Hodaka; Miyoshi, Seika; Taniguchi, Shiduku; Akimitsu, Kazuya; Gomi, Kenji

2013-06-01

Jasmonic acid (JA) and salicylic acid (SA) play important roles in plant defense systems. JA and SA signaling pathways interact antagonistically in dicotyledonous plants, but, the status of crosstalk between JA and SA signaling is unknown in monocots. Our rice microarray analysis showed that more than half of the genes upregulated by the SA analog BTH are also upregulated by JA, suggesting that a major portion of the SA-upregulated genes are regulated by JA-dependent signaling in rice. A common defense system that is activated by both JA and SA is thus proposed which plays an important role in pathogen defense responses in rice.

Jasmonic acid distribution and action in plants: regulation during development and response to biotic and abiotic stress.

PubMed Central

Creelman, R A; Mullet, J E

1995-01-01

Jasmonic acid (JA) is a naturally occurring growth regulator found in higher plants. Several physiological roles have been described for this compound (or a related compound, methyl jasmonate) during plant development and in response to biotic and abiotic stress. To accurately determine JA levels in plant tissue, we have synthesized JA containing 13C for use as an internal standard with an isotopic composition of [225]:[224] 0.98:0.02 compared with [225]:[224] 0.15:0.85 for natural material. GC analysis (flame ionization detection and MS) indicate that the internal standard is composed of 92% 2-(+/-)-[13C]JA and 8% 2-(+/-)-7-iso-[13C]JA. In soybean plants, JA levels were highest in young leaves, flowers, and fruit (highest in the pericarp). In soybean seeds and seedlings, JA levels were highest in the youngest organs including the hypocotyl hook, plumule, and 12-h axis. In soybean leaves that had been dehydrated to cause a 15% decrease in fresh weight, JA levels increased approximately 5-fold within 2 h and declined to approximately control levels by 4 h. In contrast, a lag time of 1-2 h occurred before abscisic acid accumulation reached a maximum. These results will be discussed in the context of multiple pathways for JA biosynthesis and the role of JA in plant development and responses to environmental signals. PMID:11607536

Jasmonic acid distribution and action in plants: regulation during development and response to biotic and abiotic stress.

PubMed

Creelman, R A; Mullet, J E

1995-05-09

Jasmonic acid (JA) is a naturally occurring growth regulator found in higher plants. Several physiological roles have been described for this compound (or a related compound, methyl jasmonate) during plant development and in response to biotic and abiotic stress. To accurately determine JA levels in plant tissue, we have synthesized JA containing 13C for use as an internal standard with an isotopic composition of [225]:[224] 0.98:0.02 compared with [225]:[224] 0.15:0.85 for natural material. GC analysis (flame ionization detection and MS) indicate that the internal standard is composed of 92% 2-(+/-)-[13C]JA and 8% 2-(+/-)-7-iso-[13C]JA. In soybean plants, JA levels were highest in young leaves, flowers, and fruit (highest in the pericarp). In soybean seeds and seedlings, JA levels were highest in the youngest organs including the hypocotyl hook, plumule, and 12-h axis. In soybean leaves that had been dehydrated to cause a 15% decrease in fresh weight, JA levels increased approximately 5-fold within 2 h and declined to approximately control levels by 4 h. In contrast, a lag time of 1-2 h occurred before abscisic acid accumulation reached a maximum. These results will be discussed in the context of multiple pathways for JA biosynthesis and the role of JA in plant development and responses to environmental signals.

Costs of jasmonic acid induced defense in aboveground and belowground parts of corn (Zea mays L.).

PubMed

Feng, Yuanjiao; Wang, Jianwu; Luo, Shiming; Fan, Huizhi; Jin, Qiong

2012-08-01

Costs of jasmonic acid (JA) induced plant defense have gained increasing attention. In this study, JA was applied continuously to the aboveground (AG) or belowground (BG) parts, or AG plus BG parts of corn (Zea mays L.) to investigate whether JA exposure in one part of the plant would affect defense responses in another part, and whether or not JA induced defense would incur allocation costs. The results indicated that continuous JA application to AG parts systemically affected the quantities of defense chemicals in the roots, and vice versa. Quantities of DIMBOA and total amounts of phenolic compounds in leaves or roots generally increased 2 or 4 wk after the JA treatment to different plant parts. In the first 2 wk after application, the increase of defense chemicals in leaves and roots was accompanied by a significant decrease of root length, root surface area, and root biomass. Four weeks after the JA application, however, no such costs for the increase of defense chemicals in leaves and roots were detected. Instead, shoot biomass and root biomass increased. The results suggest that JA as a defense signal can be transferred from AG parts to BG parts of corn, and vice versa. Costs for induced defense elicited by continuous JA application were found in the early 2 wk, while distinct benefits were observed later, i.e., 4 wk after JA treatment.

JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for the detection of genotoxic carcinogens: I. Summary of pre-validation study results.

PubMed

Uno, Yoshifumi; Kojima, Hajime; Omori, Takashi; Corvi, Raffaella; Honma, Masamistu; Schechtman, Leonard M; Tice, Raymond R; Burlinson, Brian; Escobar, Patricia A; Kraynak, Andrew R; Nakagawa, Yuzuki; Nakajima, Madoka; Pant, Kamala; Asano, Norihide; Lovell, David; Morita, Takeshi; Ohno, Yasuo; Hayashi, Makoto

2015-07-01

The in vivo rodent alkaline comet assay (comet assay) is used internationally to investigate the in vivo genotoxic potential of test chemicals. This assay, however, has not previously been formally validated. The Japanese Center for the Validation of Alternative Methods (JaCVAM), with the cooperation of the U.S. NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)/the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), the European Centre for the Validation of Alternative Methods (ECVAM), and the Japanese Environmental Mutagen Society/Mammalian Mutagenesis Study Group (JEMS/MMS), organized an international validation study to evaluate the reliability and relevance of the assay for identifying genotoxic carcinogens, using liver and stomach as target organs. The ultimate goal of this validation effort was to establish an Organisation for Economic Co-operation and Development (OECD) test guideline. The purpose of the pre-validation studies (i.e., Phase 1 through 3), conducted in four or five laboratories with extensive comet assay experience, was to optimize the protocol to be used during the definitive validation study. Copyright © 2015 Elsevier B.V. All rights reserved.

Evaluation of methyl methanesulfonate, 2,6-diaminotoluene and 5-fluorouracil: Part of the Japanese center for the validation of alternative methods (JaCVAM) international validation study of the in vivo rat alkaline comet assay.

PubMed

Plappert-Helbig, Ulla; Junker-Walker, Ursula; Martus, Hans-Joerg

2015-07-01

As a part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiative international validation study of the in vivo rat alkaline comet assay (comet assay), we examined methyl methanesulfonate, 2,6-diaminotoluene, and 5-fluorouracil under coded test conditions. Rats were treated orally with the maximum tolerated dose (MTD) and two additional descending doses of the respective compounds. In the MMS treated groups liver and stomach showed significantly elevated DNA damage at each dose level and a significant dose-response relationship. 2,6-diaminotoluene induced significantly elevated DNA damage in the liver at each dose and a statistically significant dose-response relationship whereas no DNA damage was obtained in the stomach. 5-fluorouracil did not induce DNA damage in either liver or stomach. Copyright © 2015 Elsevier B.V. All rights reserved.

In Silico Identification of Mimicking Molecules as Defense Inducers Triggering Jasmonic Acid Mediated Immunity against Alternaria Blight Disease in Brassica Species

PubMed Central

Pathak, Rajesh K.; Baunthiyal, Mamta; Shukla, Rohit; Pandey, Dinesh; Taj, Gohar; Kumar, Anil

2017-01-01

Alternaria brassicae and Alternaria brassicicola are two major phytopathogenic fungi which cause Alternaria blight, a recalcitrant disease on Brassica crops throughout the world, which is highly destructive and responsible for significant yield losses. Since no resistant source is available against Alternaria blight, therefore, efforts have been made in the present study to identify defense inducer molecules which can induce jasmonic acid (JA) mediated defense against the disease. It is believed that JA triggered defense response will prevent necrotrophic mode of colonization of Alternaria brassicae fungus. The JA receptor, COI1 is one of the potential targets for triggering JA mediated immunity through interaction with JA signal. In the present study, few mimicking compounds more efficient than naturally occurring JA in terms of interaction with COI1 were identified through virtual screening and molecular dynamics simulation studies. A high quality structural model of COI1 was developed using the protein sequence of Brassica rapa. This was followed by virtual screening of 767 analogs of JA from ZINC database for interaction with COI1. Two analogs viz. ZINC27640214 and ZINC43772052 showed more binding affinity with COI1 as compared to naturally occurring JA. Molecular dynamics simulation of COI1 and COI1-JA complex, as well as best screened interacting structural analogs of JA with COI1 was done for 50 ns to validate the stability of system. It was found that ZINC27640214 possesses efficient, stable, and good cell permeability properties. Based on the obtained results and its physicochemical properties, it is capable of mimicking JA signaling and may be used as defense inducers for triggering JA mediated resistance against Alternaria blight, only after further validation through field trials. PMID:28487711

Methyl jasmonate-induced defense responses are associated with elevation of 1-aminocyclopropane-1-carboxylate oxidase in Lycopersicon esculentum fruit.

PubMed

Yu, Mengmeng; Shen, Lin; Zhang, Aijun; Sheng, Jiping

2011-10-15

It has been known that methyl jasmonate (MeJA) interacts with ethylene to elicit resistance. In green mature tomato fruits (Lycopersicon esculentum cv. Lichun), 0.02mM MeJA increased the activity of 1-aminocyclopropane-1-carboxylate oxidase (ACO), and consequently influenced the last step of ethylene biosynthesis. Fruits treated with a combination of 0.02 MeJA and 0.02 α-aminoisobutyric acid (AIB, a competitive inhibitor of ACO) exhibited a lower ethylene production comparing to that by 0.02mM MeJA alone. The increased activities of defense enzymes and subsequent control of disease incidence caused by Botrytis cinerea with 0.2mM MeJA treatment was impaired by AIB as well. A close relationship (P<0.05) was found between the activity alterations of ACO and that of chitinase (CHI) and β-1,3-glucanase (GLU). In addition, this study further detected the changes of gene expressions and enzyme kinetics of ACO to different concentrations of MeJA. LeACO1 was found the principal member from the ACO gene family to respond to MeJA. Accumulation of LeACO1/3/4 transcripts followed the concentration pattern of MeJA treatments, where the largest elevations were reached by 0.2mM. For kinetic analysis, K(m) values of ACO stepped up during the experiment and reached the maximums at 0.2mM MeJA with ascending concentrations of treatments. V(max) exhibited a gradual increase from 3h to 24h, and the largest induction appeared with 1.0mM MeJA. The results suggested that ACO is involved in MeJA-induced resistance in tomato, and the concentration influence of MeJA on ACO was attributable to the variation of gene transcripts and enzymatic properties. Copyright © 2011 Elsevier GmbH. All rights reserved.

Transcriptome Analysis of Genes Associated with the Artemisinin Biosynthesis by Jasmonic Acid Treatment under the Light in Artemisia annua

PubMed Central

Hao, Xiaolong; Zhong, Yijun; Fu, Xueqing; Lv, Zongyou; Shen, Qian; Yan, Tingxiang; Shi, Pu; Ma, Yanan; Chen, Minghui; Lv, Xueying; Wu, Zhangkuanyu; Zhao, Jingya; Sun, Xiaofen; Li, Ling; Tang, Kexuan

2017-01-01

Artemisinin is a sesquiterpene lactone endoperoxide extracted from a traditional Chinese medicinal plant Artemisia annua. Artemisinin-based combination therapies (ACTs) are recommended as the best treatment of malaria by the World Health Organization (WHO). Both the phytohormone jasmonic acid (JA) and light promote artemisinin biosynthesis in A. annua. Interestingly, we found that the increase of artemisinin biosynthesis by JA was dependent on light. However, the relationship between the two signal pathways mediated by JA and light remains unclear. Here, we collected the A. annua seedlings of 24 h continuous light (Light), 24 h dark treatment (Dark), 4 h MeJA treatment under the continuous light conditions (Light-MeJA-4h) and 4 h MeJA treatment under the dark conditions (Dark-MeJA-4h) and performed the transcriptome sequencing using Illumina HiSeq 4000 System. A total of 266.7 million clean data were produced and assembled into 185,653 unigenes, with an average length of 537 bp. Among them, 59,490 unigenes were annotated and classified based on the public information. Differential expression analyses were performed between Light and Dark, Light and Light-MeJA-4h, Dark and Dark-MeJA-4h, Light-MeJA-4h, and Dark-MeJA-4h, respectively. Furthermore, transcription factor (TF) analysis revealed that 1588 TFs were identified and divided into 55 TF families, with 284 TFs down-regulated in the Dark relative to Light and 96 TFs up-regulated in the Light-MeJA-4h relative to Light. 8 TFs were selected as candidates for regulating the artemisinin biosynthesis and one of them was validated to be involved in artemisinin transcriptional regulation by Dual-Luciferase (Dual-LUC) assay. The transcriptome data shown in our study offered a comprehensive transcriptional expression pattern influenced by the MeJA and light in A. annua seedling, which will serve as a valuable resource for further studies on transcriptional regulation mechanisms underlying artemisinin biosynthesis. PMID

Unclassified Publications of Lincoln Laboratory 1 January-31 December 1993. Volume 19

DTIC Science & Technology

1993-12-31

Netishen, CM. Rothschild, M. Blundell, R Papa, D.C. Brown, E.R. Parker, CD. Shirley, L.G. Ariel, E.D. Hallerman , G.R. Payson, H.C Vivilecchia...Gustafson, T.K., JA-6838 Hallerman , G.R., JA-6932 Hallowell, R.G., MS-10253 Halversen, S.D., JA-6948, MS-10057, MS-10114 Hanes, A.S., JA-6924

Defense Priming and Jasmonates: A Role for Free Fatty Acids in Insect Elicitor-Induced Long Distance Signaling

PubMed Central

Li, Ting; Cofer, Tristan; Engelberth, Marie; Engelberth, Jurgen

2016-01-01

Green leaf volatiles (GLV) prime plants against insect herbivore attack resulting in stronger and faster signaling by jasmonic acid (JA). In maize this response is specifically linked to insect elicitor (IE)-induced signaling processes, which cause JA accumulation not only around the damage site, but also in distant tissues, presumably through the activation of electrical signals. Here, we present additional data further characterizing these distal signaling events in maize. Also, we describe how exposure to GLV increases free fatty acid (fFA) levels in maize seedlings, but also in other plants, and how increased fFA levels affect IE-induced JA accumulation. Increased fFA, in particular α-linolenic acid (LnA), caused a significant increase in JA accumulation after IE treatment, while JA induced by mechanical wounding (MW) alone was not affected. We also identified treatments that significantly decreased certain fFA level including simulated wind and rain. In such treated plants, IE-induced JA accumulation was significantly reduced when compared to un-moved control plants, while MW-induced JA accumulation was not significantly affected. Since only IE-induced JA accumulation was altered by changes in the fFA composition, we conclude that changing levels of fFA affect primarily IE-induced signaling processes rather than serving as a substrate for JA. PMID:27135225

Jasmonate induction of the monoterpene linalool confers resistance to rice bacterial blight and its biosynthesis is regulated by JAZ protein in rice.

PubMed

Taniguchi, Shiduku; Hosokawa-Shinonaga, Yumi; Tamaoki, Daisuke; Yamada, Shoko; Akimitsu, Kazuya; Gomi, Kenji

2014-02-01

Jasmonic acid (JA) is involved in the regulation of host immunity in plants. Recently, we demonstrated that JA signalling has an important role in resistance to rice bacterial blight caused by Xanthomonas oryzae pv. oryzae (Xoo) in rice. Here, we report that many volatile compounds accumulate in response to exogenous application of JA, including the monoterpene linalool. Expression of linalool synthase was up-regulated by JA. Vapour treatment with linalool induced resistance to Xoo, and transgenic rice plants overexpressing linalool synthase were more resistance to Xoo, presumably due to the up-regulation of defence-related genes in the absence of any treatment. JA-induced accumulation of linalool was regulated by OsJAZ8, a rice jasmonate ZIM-domain protein involving the JA signalling pathway at the transcriptional level, suggesting that linalool plays an important role in JA-induced resistance to Xoo in rice. © 2013 John Wiley & Sons Ltd.

Cognitive and adaptive correlates of an ADOS-derived joint attention composite

PubMed Central

Harrison, Ashley Johnson; Lu, Zhenqiu (Laura); McLean, Rebecca L.; Sheinkopf, Stephen J.

2016-01-01

Joint attention skills have been shown to predict language outcomes in children with autism spectrum disorder (ASD). Less is known about the relationship between joint attention (JA) abilities in children with ASD and cognitive and adaptive abilities. In the current study, a subset of items from the Autism Diagnostic Observation Schedule (ADOS), designed to quantify JA abilities, were used to investigate social attention among an unusually large cross-sectional sample of children with ASD (n = 1061). An examination of the association between JA and a range of functional correlates (cognitive and adaptive) revealed JA was significantly related to verbal (VIQ) and non-verbal (NVIQ) cognitive ability as well as all domains of adaptive functioning (socialization, communication, and daily living skills). Additional analyses examined the degree to which the relation between adaptive abilities (socialization, communication, and daily living skills) and JA was maintained after taking into account the potentially mediating role of verbal and nonverbal cognitive ability. Results revealed that VIQ fully mediated the relation between JA and adaptive functioning, whereas the relation between these adaptive variables and JA was only partially mediated by NVIQ. Moderation analyses were also conducted to examine how verbal and non-verbal cognitive ability and gender impacted the relation between JA and adaptive functioning. In line with research showing a relation between language and JA, this indicates that while JA is significantly related to functional outcomes, this appears to be mediated specifically through a verbal cognitive pathway. PMID:28168003

Jasmonoyl-l-Isoleucine Coordinates Metabolic Networks Required for Anthesis and Floral Attractant Emission in Wild Tobacco (Nicotiana attenuata)[C][W][OPEN

PubMed Central

Stitz, Michael; Hartl, Markus; Baldwin, Ian T.; Gaquerel, Emmanuel

2014-01-01

Jasmonic acid and its derivatives (jasmonates [JAs]) play central roles in floral development and maturation. The binding of jasmonoyl-l-isoleucine (JA-Ile) to the F-box of CORONATINE INSENSITIVE1 (COI1) is required for many JA-dependent physiological responses, but its role in anthesis and pollinator attraction traits remains largely unexplored. Here, we used the wild tobacco Nicotiana attenuata, which develops sympetalous flowers with complex pollination biology, to examine the coordinating function of JA homeostasis in the distinct metabolic processes that underlie flower maturation, opening, and advertisement to pollinators. From combined transcriptomic, targeted metabolic, and allometric analyses of transgenic N. attenuata plants for which signaling deficiencies were complemented with methyl jasmonate, JA-Ile, and its functional homolog, coronatine (COR), we demonstrate that (1) JA-Ile/COR-based signaling regulates corolla limb opening and a JA-negative feedback loop; (2) production of floral volatiles (night emissions of benzylacetone) and nectar requires JA-Ile/COR perception through COI1; and (3) limb expansion involves JA-Ile-induced changes in limb fresh mass and carbohydrate metabolism. These findings demonstrate a master regulatory function of the JA-Ile/COI1 duet for the main function of a sympetalous corolla, that of advertising for and rewarding pollinator services. Flower opening, by contrast, requires JA-Ile signaling-dependent changes in primary metabolism, which are not compromised in the COI1-silenced RNA interference line used in this study. PMID:25326292

Insect-Induced Conifer Defense. White Pine Weevil and Methyl Jasmonate Induce Traumatic Resinosis, de Novo Formed Volatile Emissions, and Accumulation of Terpenoid Synthase and Putative Octadecanoid Pathway Transcripts in Sitka Spruce1[w

PubMed Central

Miller, Barbara; Madilao, Lufiani L.; Ralph, Steven; Bohlmann, Jörg

2005-01-01

Stem-boring insects and methyl jasmonate (MeJA) are thought to induce similar complex chemical and anatomical defenses in conifers. To compare insect- and MeJA-induced terpenoid responses, we analyzed traumatic oleoresin mixtures, emissions of terpenoid volatiles, and expression of terpenoid synthase (TPS) genes in Sitka spruce (Picea sitchensis) following attack by white pine weevils (Pissodes strobi) or application of MeJA. Both insects and MeJA caused traumatic resin accumulation in stems, with more accumulation induced by the weevils. Weevil-induced terpenoid emission profiles were also more complex than emissions induced by MeJA. Weevil feeding caused a rapid release of a blend of monoterpene olefins, presumably by passive evaporation of resin compounds from stem feeding sites. These compounds were not found in MeJA-induced emissions. Both weevils and MeJA caused delayed, diurnal emissions of (−)-linalool, indicating induced de novo biosynthesis of this compound. TPS transcripts strongly increased in stems upon insect attack or MeJA treatment. Time courses and intensity of induced TPS transcripts were different for monoterpene synthases, sesquiterpene synthases, and diterpene synthases. Increased levels of weevil- and MeJA-induced TPS transcripts accompanied major changes in terpenoid accumulation in stems. Induced TPS expression profiles in needles were less complex than those in stems and matched induced de novo emissions of (−)-linalool. Overall, weevils and MeJA induced similar, but not identical, terpenoid defense responses in Sitka spruce. Findings of insect- and MeJA-induced accumulation of allene oxide synthase-like and allene oxide cyclase-like transcripts are discussed in the context of traumatic resinosis and induced volatile emissions in this gymnosperm system. PMID:15618433

Methyl jasmonate as an allelopathic agent: sagebrush inhibits germination of a neighboring tobacco, Nicotiana attenuata.

PubMed

Preston, Catherine A; Betts, Hazel; Baldwi, Ian T

2002-11-01

Artemisia tridentata ssp. tridentata is the dominant and defining shrub in the Great Basin Desert, with well-documented allelopathic tendencies that have generally been ascribed to its most abundantly released secondary metabolites. However, as a minor component, sagebrush releases a highly biologically active substance, methyljasmonate (MeJA), which is known to function as both a germination inhibitor and promoter in laboratory studies. Nicotiana attenuata is a tobacco species native to the Great Basin Desert and grows in newly burned juniper-sagebrush habitats for 2-3 yr following a fire. With a combination of field and laboratory studies, we examined the role of MeJA release from sagebrush by both air and water transport in inhibiting N. attenuata seed germination. We demonstrated that sagebrush interacts allelopathically with the seed bank of N. attenuata through its release of MeJA. In the field, seeds buried 0-40 cm from sagebrush plants for 4 months in net bags had significantly reduced germination compared to seeds buried similarly but protected in plastic bags. Moreover, germination on soils collected from underneath sagebrush plants was reduced by 60% compared to seeds placed on soils collected between sagebrush plants or outside of the sagebrush population. Exposure to A. tridentata seeds and seedlings did not affect N. attenuata germination, suggesting that established sagebrush plants only influence the tobacco's seed bank. In the laboratory, exposure of seeds to sagebrush emissions resulted in germination delays of up to 6 d. Exposure to volatile and aqueous MeJA also inhibited germination of N. attenuata seeds at quantities that are released naturally by sagebrush: 3.5 microg/hr and 1.12 microg/seed cup (56 ng/seed), respectively. A. tridentata seeds were significantly more resistant to MeJA, being inhibited at 336 microg MeJA (16.8 microg/seed), 300 times greater than the level of aqueous MeJA required to inhibit N. attenuata seeds. MeJA inhibited N

17 CFR Appendix 1 to Part 45 - Tables of Minimum Primary Economic Terms Data

Code of Federal Regulations, 2014 CFR

2014-04-01

... 17 Commodity and Securities Exchanges 2 2014-04-01 2014-04-01 false Tables of Minimum Primary Economic Terms Data 1 Appendix 1 to Part 45 Commodity and Securities Exchanges COMMODITY FUTURES TRADING... 45—Tables of Minimum Primary Economic Terms Data ER13JA12.003 ER13JA12.004 ER13JA12.005 ER13JA12.006...

Adverse Childhood Experiences among a Community of Resilient Centenarians and Seniors: Implications for a Chronic Disease Prevention Framework

PubMed Central

Spencer-Hwang, Rhonda; Torres, Xochitl; Valladares, Johanny; Pasco-Rubio, Marco; Dougherty, Molly; Kim, Wonha

2018-01-01

Context Research has linked adverse childhood experiences (ACEs) with chronic disease in adults and diminished life span. Adverse biological embedding of ACEs potentially occurs through inflammatory mechanisms; inflammatory marker alterations are identified as candidate biomarkers for mediating health consequences. Lifestyle practices of residents of California’s Loma Linda Blue Zone, one of five worldwide longevity hotspots, may provide insight into inflammation remediation and chronic disease prevention. Little research has been done on centenarians’ early-life experiences or on ACEs in a longevity community. Objective To interview centenarians and seniors in this region regarding their childhood experiences to inform chronic disease prevention frameworks. Design Qualitative study of Loma Linda Blue Zone community members. Childhood exposures and practices were assessed using focus groups and semistructured key informant interviews, with open-ended questions on general hardships and ACEs and supplemented with lifestyle and resiliency factor questions. Data were audiorecorded and transcribed. Integrative grounded theory methods guided coding and theming. Main Outcome Measures Exposure to ACEs and practice of resiliency factors. Results Participants (7 centenarians and 29 seniors) reported exposure to multiple ACEs (domains: Economic deprivation, family dysfunction, and community violence). Community members reported practicing resiliency factors, each with anti-inflammatory properties suggesting mitigation of ACE-related toxic stress. Conclusion This is one of the first studies of its kind to identify a community of resilient members despite their tremendous burden of ACEs. Embedding the identified resiliency factors into chronic disease prevention frameworks has potential for mitigating systemic inflammation, alleviating chronic disease burden, and promoting a culture of health. PMID:29702049

Feeding by whiteflies suppresses downstream jasmonic acid signaling by eliciting salicylic acid signaling.

PubMed

Zhang, Peng-Jun; Li, Wei-Di; Huang, Fang; Zhang, Jin-Ming; Xu, Fang-Cheng; Lu, Yao-Bin

2013-05-01

Phloem-feeding whiteflies in the species complex Bemisia tabaci cause extensive crop damage worldwide. One of the reasons for their "success" is their ability to suppress the effectual jasmonic acid (JA) defenses of the host plant. However, little is understood about the mechanisms underlying whitefly suppression of JA-regulated defenses. Here, we showed that the expression of salicylic acid (SA)-responsive genes (EDS1 and PR1) in Arabidopsis thaliana was significantly enhanced during feeding by whitefly nymphs. Whereas upstream JA-responsive genes (LOX2 and OPR3) also were induced, the downstream JA-responsive gene (VSP1) was repressed, i.e., whiteflies only suppressed downstream JA signaling. Gene-expression analyses with various Arabidopsis mutants, including NahG, npr-1, ein2-1, and dde2-2, revealed that SA signaling plays a key role in the suppression of downstream JA defenses by whitefly feeding. Assays confirmed that SA activation enhanced whitefly performance by suppressing downstream JA defenses.

TIME FOR COFFEE Represses Accumulation of the MYC2 Transcription Factor to Provide Time-of-Day Regulation of Jasmonate Signaling in Arabidopsis[C][W][OA

PubMed Central

Shin, Jieun; Heidrich, Katharina; Sanchez-Villarreal, Alfredo; Parker, Jane E.; Davis, Seth J.

2012-01-01

Plants are confronted with predictable daily biotic and abiotic stresses that result from the day–night cycle. The circadian clock provides an anticipation mechanism to respond to these daily stress signals to increase fitness. Jasmonate (JA) is a phytohormone that mediates various growth and stress responses. Here, we found that the circadian-clock component TIME FOR COFFEE (TIC) acts as a negative factor in the JA-signaling pathway. We showed that the tic mutant is hypersensitive to growth-repressive effects of JA and displays altered JA-regulated gene expression. TIC was found to interact with MYC2, a key transcription factor of JA signaling. From this, we discovered that the circadian clock rhythmically regulates JA signaling. TIC is a key determinant in this circadian-gated process, and as a result, the tic mutant is defective in rhythmic JA responses to pathogen infection. TIC acts here by inhibiting MYC2 protein accumulation and by controlling the transcriptional repression of CORONATINE INSENSITIVE1 in an evening-phase–specific manner. Taken together, we propose that TIC acts as an output component of the circadian oscillator to influence JA signaling directly. PMID:22693280

Involvement of nitric oxide in the jasmonate-dependent basal defense against root-knot nematode in tomato plants.

PubMed

Zhou, Jie; Jia, Feifei; Shao, Shujun; Zhang, Huan; Li, Guiping; Xia, Xiaojian; Zhou, Yanhong; Yu, Jingquan; Shi, Kai

2015-01-01

Jasmonic acid (JA) and nitric oxide (NO) are well-characterized signaling molecules in plant defense responses. However, their roles in plant defense against root-knot nematode (RKN, Meloidogyne incognita) infection are largely unknown. In this study, we found that the transcript levels of the JA- and NO-related biosynthetic and signaling component genes were induced after RKN infection. Application of exogenous JA and sodium nitroprusside (SNP; a NO donor) significantly decreased the number of egg masses in tomato roots after RKN infection and partially alleviated RKN-induced decreases in plant fresh weight and net photosynthetic rate. These molecules also alleviated RKN-induced increases in root electrolyte leakage and membrane peroxidation. Importantly, NO scavenger partially inhibited JA-induced RKN defense. The pharmacological inhibition of JA biosynthesis significantly increased the plants' susceptibility to RKNs, which was effectively alleviated by SNP application, showing that NO may be involved in the JA-dependent RKN defense pathway. Furthermore, both JA and SNP induced increases in protease inhibitor 2 (PI2) gene expression after RKN infestation. Silencing of PI2 compromised both JA- and SNP-induced RKN defense responses, suggesting that the PI2 gene mediates JA- and NO-induced defense against RKNs. This work will be important for deepening the understanding of the mechanisms involved in basal defense against RKN attack in plants.

Contrasting nutrient-disease relationships: Potassium gradients in barley leaves have opposite effects on two fungal pathogens with different sensitivities to jasmonic acid.

PubMed

Davis, Jayne L; Armengaud, Patrick; Larson, Tony R; Graham, Ian A; White, Philip J; Newton, Adrian C; Amtmann, Anna

2018-05-31

Understanding the interactions between mineral nutrition and disease is essential for crop management. Our previous studies with Arabidopsis thaliana demonstrated that potassium (K) deprivation induced the biosynthesis of jasmonate (JA) and increased the plant's resistance to herbivorous insects. Here we addressed the question how tissue K affects the development of fungal pathogens and whether sensitivity of the pathogens to JA could play a role for the K-disease relationship in barley (Hordeum vulgare cv. Optic). We report that K-deprived barley plants showed increased leaf concentrations of JA and other oxylipins. Furthermore, a natural tip-to base K-concentrations gradient within leaves of K-sufficient plants was quantitatively mirrored by the transcript levels of JA-responsive genes. The local leaf tissue K concentrations affected the development of two economically important fungi in opposite ways, showing a positive correlation with powdery mildew (Blumeria graminis) and a negative correlation with leaf scald (Rhynchosporium commune) disease symptoms. B. graminis induced a JA-response in the plant and was sensitive to methyl-JA treatment while R. commune initiated no JA-response and was JA-insensitive. Our study challenges the view that high K generally improves plant health and suggests that JA-sensitivity of pathogens could be an important factor determining the exact K-disease relationship. This article is protected by copyright. All rights reserved.

MYC2 Orchestrates a Hierarchical Transcriptional Cascade That Regulates Jasmonate-Mediated Plant Immunity in Tomato.

PubMed

Du, Minmin; Zhao, Jiuhai; Tzeng, David T W; Liu, Yuanyuan; Deng, Lei; Yang, Tianxia; Zhai, Qingzhe; Wu, Fangming; Huang, Zhuo; Zhou, Ming; Wang, Qiaomei; Chen, Qian; Zhong, Silin; Li, Chang-Bao; Li, Chuanyou

2017-08-01

The hormone jasmonate (JA), which functions in plant immunity, regulates resistance to pathogen infection and insect attack through triggering genome-wide transcriptional reprogramming in plants. We show that the basic helix-loop-helix transcription factor (TF) MYC2 in tomato ( Solanum lycopersicum ) acts downstream of the JA receptor to orchestrate JA-mediated activation of both the wounding and pathogen responses. Using chromatin immunoprecipitation sequencing (ChIP-seq) coupled with RNA sequencing (RNA-seq) assays, we identified 655 MYC2-targeted JA-responsive genes. These genes are highly enriched in Gene Ontology categories related to TFs and the early response to JA, indicating that MYC2 functions at a high hierarchical level to regulate JA-mediated gene transcription. We also identified a group of MYC2-targeted TFs (MTFs) that may directly regulate the JA-induced transcription of late defense genes. Our findings suggest that MYC2 and its downstream MTFs form a hierarchical transcriptional cascade during JA-mediated plant immunity that initiates and amplifies transcriptional output. As proof of concept, we showed that during plant resistance to the necrotrophic pathogen Botrytis cinerea , MYC2 and the MTF JA2-Like form a transcription module that preferentially regulates wounding-responsive genes, whereas MYC2 and the MTF ETHYLENE RESPONSE FACTOR.C3 form a transcription module that preferentially regulates pathogen-responsive genes. © 2017 American Society of Plant Biologists. All rights reserved.

MYC2 Orchestrates a Hierarchical Transcriptional Cascade That Regulates Jasmonate-Mediated Plant Immunity in Tomato[OPEN

PubMed Central

Liu, Yuanyuan; Deng, Lei; Wu, Fangming; Huang, Zhuo; Zhou, Ming; Chen, Qian; Zhong, Silin

2017-01-01

The hormone jasmonate (JA), which functions in plant immunity, regulates resistance to pathogen infection and insect attack through triggering genome-wide transcriptional reprogramming in plants. We show that the basic helix-loop-helix transcription factor (TF) MYC2 in tomato (Solanum lycopersicum) acts downstream of the JA receptor to orchestrate JA-mediated activation of both the wounding and pathogen responses. Using chromatin immunoprecipitation sequencing (ChIP-seq) coupled with RNA sequencing (RNA-seq) assays, we identified 655 MYC2-targeted JA-responsive genes. These genes are highly enriched in Gene Ontology categories related to TFs and the early response to JA, indicating that MYC2 functions at a high hierarchical level to regulate JA-mediated gene transcription. We also identified a group of MYC2-targeted TFs (MTFs) that may directly regulate the JA-induced transcription of late defense genes. Our findings suggest that MYC2 and its downstream MTFs form a hierarchical transcriptional cascade during JA-mediated plant immunity that initiates and amplifies transcriptional output. As proof of concept, we showed that during plant resistance to the necrotrophic pathogen Botrytis cinerea, MYC2 and the MTF JA2-Like form a transcription module that preferentially regulates wounding-responsive genes, whereas MYC2 and the MTF ETHYLENE RESPONSE FACTOR.C3 form a transcription module that preferentially regulates pathogen-responsive genes. PMID:28733419

Involvement of nitric oxide in the jasmonate-dependent basal defense against root-knot nematode in tomato plants

PubMed Central

Zhou, Jie; Jia, Feifei; Shao, Shujun; Zhang, Huan; Li, Guiping; Xia, Xiaojian; Zhou, Yanhong; Yu, Jingquan; Shi, Kai

2015-01-01

Jasmonic acid (JA) and nitric oxide (NO) are well-characterized signaling molecules in plant defense responses. However, their roles in plant defense against root-knot nematode (RKN, Meloidogyne incognita) infection are largely unknown. In this study, we found that the transcript levels of the JA- and NO-related biosynthetic and signaling component genes were induced after RKN infection. Application of exogenous JA and sodium nitroprusside (SNP; a NO donor) significantly decreased the number of egg masses in tomato roots after RKN infection and partially alleviated RKN-induced decreases in plant fresh weight and net photosynthetic rate. These molecules also alleviated RKN-induced increases in root electrolyte leakage and membrane peroxidation. Importantly, NO scavenger partially inhibited JA-induced RKN defense. The pharmacological inhibition of JA biosynthesis significantly increased the plants’ susceptibility to RKNs, which was effectively alleviated by SNP application, showing that NO may be involved in the JA-dependent RKN defense pathway. Furthermore, both JA and SNP induced increases in protease inhibitor 2 (PI2) gene expression after RKN infestation. Silencing of PI2 compromised both JA- and SNP-induced RKN defense responses, suggesting that the PI2 gene mediates JA- and NO-induced defense against RKNs. This work will be important for deepening the understanding of the mechanisms involved in basal defense against RKN attack in plants. PMID:25914698

The Calcium-Dependent Protein Kinase CPK28 Regulates Development by Inducing Growth Phase-Specific, Spatially Restricted Alterations in Jasmonic Acid Levels Independent of Defense Responses in Arabidopsis[OPEN

PubMed Central

Matschi, Susanne; Hake, Katharina; Herde, Marco; Hause, Bettina; Romeis, Tina

2015-01-01

Phytohormones play an important role in development and stress adaptations in plants, and several interacting hormonal pathways have been suggested to accomplish fine-tuning of stress responses at the expense of growth. This work describes the role played by the CALCIUM-DEPENDENT PROTEIN KINASE CPK28 in balancing phytohormone-mediated development in Arabidopsis thaliana, specifically during generative growth. cpk28 mutants exhibit growth reduction solely as adult plants, coinciding with altered balance of the phytohormones jasmonic acid (JA) and gibberellic acid (GA). JA-dependent gene expression and the levels of several JA metabolites were elevated in a growth phase-dependent manner in cpk28, and accumulation of JA metabolites was confined locally to the central rosette tissue. No elevated resistance toward herbivores or necrotrophic pathogens was detected for cpk28 plants, either on the whole-plant level or specifically within the tissue displaying elevated JA levels. Abolishment of JA biosynthesis or JA signaling led to a full reversion of the cpk28 growth phenotype, while modification of GA signaling did not. Our data identify CPK28 as a growth phase-dependent key negative regulator of distinct processes: While in seedlings, CPK28 regulates reactive oxygen species-mediated defense signaling; in adult plants, CPK28 confers developmental processes by the tissue-specific balance of JA and GA without affecting JA-mediated defense responses. PMID:25736059

Characterization of a JAZ7 activation-tagged Arabidopsis mutant with increased susceptibility to the fungal pathogen Fusarium oxysporum

PubMed Central

Thatcher, Louise F.; Cevik, Volkan; Grant, Murray; Zhai, Bing; Jones, Jonathan D.G.; Manners, John M.; Kazan, Kemal

2016-01-01

In Arabidopsis, jasmonate (JA)-signaling plays a key role in mediating Fusarium oxysporum disease outcome. However, the roles of JASMONATE ZIM-domain (JAZ) proteins that repress JA-signaling have not been characterized in host resistance or susceptibility to this pathogen. Here, we found most JAZ genes are induced following F. oxysporum challenge, and screening T-DNA insertion lines in Arabidopsis JAZ family members identified a highly disease-susceptible JAZ7 mutant (jaz7-1D). This mutant exhibited constitutive JAZ7 expression and conferred increased JA-sensitivity, suggesting activation of JA-signaling. Unlike jaz7 loss-of-function alleles, jaz7-1D also had enhanced JA-responsive gene expression, altered development and increased susceptibility to the bacterial pathogen Pst DC3000 that also disrupts host JA-responses. We also demonstrate that JAZ7 interacts with transcription factors functioning as activators (MYC3, MYC4) or repressors (JAM1) of JA-signaling and contains a functional EAR repressor motif mediating transcriptional repression via the co-repressor TOPLESS (TPL). We propose through direct TPL recruitment, in wild-type plants JAZ7 functions as a repressor within the JA-response network and that in jaz7-1D plants, misregulated ectopic JAZ7 expression hyper-activates JA-signaling in part by disturbing finely-tuned COI1-JAZ-TPL-TF complexes. PMID:26896849

Multimorbidity care model: Recommendations from the consensus meeting of the Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS).

PubMed

Palmer, Katie; Marengoni, Alessandra; Forjaz, Maria João; Jureviciene, Elena; Laatikainen, Tiina; Mammarella, Federica; Muth, Christiane; Navickas, Rokas; Prados-Torres, Alexandra; Rijken, Mieke; Rothe, Ulrike; Souchet, Laurène; Valderas, Jose; Vontetsianos, Theodore; Zaletel, Jelka; Onder, Graziano

2018-01-01

Patients with multimorbidity have complex health needs but, due to the current traditional disease-oriented approach, they face a highly fragmented form of care that leads to inefficient, ineffective, and possibly harmful clinical interventions. There is limited evidence on available integrated and multidimensional care pathways for multimorbid patients. An expert consensus meeting was held to develop a framework for care of multimorbid patients that can be applied across Europe, within a project funded by the European Union; the Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS). The experts included a diverse group representing care providers and patients, and included general practitioners, family medicine physicians, neurologists, geriatricians, internists, cardiologists, endocrinologists, diabetologists, epidemiologists, psychologists, and representatives from patient organizations. Sixteen components across five domains were identified (Delivery of Care; Decision Support; Self Management Support; Information Systems and Technology; and Social and Community Resources). The description and aim of each component are described in these guidelines, along with a summary of key characteristics and relevance to multimorbid patients. Due to the lack of evidence-based recommendations specific to multimorbid patients, this care model needs to be assessed and validated in different European settings to examine specifically how multimorbid patients will benefit from this care model, and whether certain components have more importance than others. Copyright © 2017 Elsevier B.V. All rights reserved.

The endoscopic endonasal approach for the treatment of juvenile angiofibromas.

PubMed

Llorente, José Luis; López, Fernando

2018-05-12

Juvenile angiofibroma (JA) is a benign tumour, for which the treatment of choice is surgery. It may be associated with significant morbidity because of its anatomical location and its locally destructive growth pattern. Severe haemorrhage constitutes a high risk in JA and its surgical management can be complex. The management of JA remains a challenge. The objective of this study was to review a series of patients with JA treated via the endonasal/endoscopic approach. Medical records of patients operated for JA were reviewed. tumour stage, intraoperative blood loss, complications and persistence/recurrence rates. A total of 30 male patients and one female were included. The mean age was 17 years. Using the Radkowski classification, one JA was classified as stage I, 5 stage IIA, 9 stage IIB, 4 stage IIC, 10 stage IIIA and 2 stage IIIB. Thirty-nine percent of the JA was classified as advanced stage JA (IIIA and IIIB). The mean blood loss was 1.156mL Except in one case, no significant complications were observed. Tumour persistence/recurrence was observed in 2 JA (6%), at the end of the follow-up. Mean postoperative follow-up time was 86 months. This retrospective study supports the notion that endonasal endoscopic approaches for a JA are a feasible option associated with good long-term results. Copyright © 2018 Sociedad Española de Otorrinolaringología y Cirugía de Cabeza y Cuello. Publicado por Elsevier España, S.L.U. All rights reserved.

Both the Jasmonic Acid and the Salicylic Acid Pathways Contribute to Resistance to the Biotrophic Clubroot Agent Plasmodiophora brassicae in Arabidopsis.

PubMed

Lemarié, Séverine; Robert-Seilaniantz, Alexandre; Lariagon, Christine; Lemoine, Jocelyne; Marnet, Nathalie; Jubault, Mélanie; Manzanares-Dauleux, Maria J; Gravot, Antoine

2015-11-01

The role of salicylic acid (SA) and jasmonic acid (JA) signaling in resistance to root pathogens has been poorly documented. We assessed the contribution of SA and JA to basal and partial resistance of Arabidopsis to the biotrophic clubroot agent Plasmodiophora brassicae. SA and JA levels as well as the expression of the SA-responsive genes PR2 and PR5 and the JA-responsive genes ARGAH2 and THI2.1 were monitored in infected roots of the accessions Col-0 (susceptible) and Bur-0 (partially resistant). SA signaling was activated in Bur-0 but not in Col-0. The JA pathway was weakly activated in Bur-0 but was strongly induced in Col-0. The contribution of both pathways to clubroot resistance was then assessed using exogenous phytohormone application and mutants affected in SA or JA signaling. Exogenous SA treatment decreased clubroot symptoms in the two Arabidopsis accessions, whereas JA treatment reduced clubroot symptoms only in Col-0. The cpr5-2 mutant, in which SA responses are constitutively induced, was more resistant to clubroot than the corresponding wild type, and the JA signaling-deficient mutant jar1 was more susceptible. Finally, we showed that the JA-mediated induction of NATA1 drove N(δ)-acetylornithine biosynthesis in infected Col-0 roots. The 35S::NATA1 and nata1 lines displayed reduced or enhanced clubroot symptoms, respectively, thus suggesting that in Col-0 this pathway was involved in the JA-mediated basal clubroot resistance. Overall, our data support the idea that, depending on the Arabidopsis accession, both SA and JA signaling can play a role in partial inhibition of clubroot development in compatible interactions with P. brassicae. © The Author 2015. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Multilayered Organization of Jasmonate Signalling in the Regulation of Root Growth

PubMed Central

Gasperini, Debora; Chételat, Aurore; Acosta, Ivan F.; Goossens, Jonas; Pauwels, Laurens; Goossens, Alain; Dreos, René; Alfonso, Esteban; Farmer, Edward E.

2015-01-01

Physical damage can strongly affect plant growth, reducing the biomass of developing organs situated at a distance from wounds. These effects, previously studied in leaves, require the activation of jasmonate (JA) signalling. Using a novel assay involving repetitive cotyledon wounding in Arabidopsis seedlings, we uncovered a function of JA in suppressing cell division and elongation in roots. Regulatory JA signalling components were then manipulated to delineate their relative impacts on root growth. The new transcription factor mutant myc2-322B was isolated. In vitro transcription assays and whole-plant approaches revealed that myc2-322B is a dosage-dependent gain-of-function mutant that can amplify JA growth responses. Moreover, myc2-322B displayed extreme hypersensitivity to JA that totally suppressed root elongation. The mutation weakly reduced root growth in undamaged plants but, when the upstream negative regulator NINJA was genetically removed, myc2-322B powerfully repressed root growth through its effects on cell division and cell elongation. Furthermore, in a JA-deficient mutant background, ninja1 myc2-322B still repressed root elongation, indicating that it is possible to generate JA-responses in the absence of JA. We show that NINJA forms a broadly expressed regulatory layer that is required to inhibit JA signalling in the apex of roots grown under basal conditions. By contrast, MYC2, MYC3 and MYC4 displayed cell layer-specific localisations and MYC3 and MYC4 were expressed in mutually exclusive regions. In nature, growing roots are likely subjected to constant mechanical stress during soil penetration that could lead to JA production and subsequent detrimental effects on growth. Our data reveal how distinct negative regulatory layers, including both NINJA-dependent and -independent mechanisms, restrain JA responses to allow normal root growth. Mechanistic insights from this work underline the importance of mapping JA signalling components to specific

Safety and quality parameters of ready-to-cook minced pork meat products supplemented with Helianthus tuberosus L. tubers fermented by BLIS producing lactic acid bacteria.

PubMed

Stimbirys, Arturas; Bartkiene, Elena; Siugzdaite, Jurate; Augeniene, Dovile; Vidmantiene, Daiva; Juodeikiene, Grazina; Maruska, Audrius; Stankevicius, Mantas; Cizeikiene, Dalia

2015-07-01

The aim of this study was to evaluate the influence of additives of Jerusalem artichoke (JA), fermented with P. acidilactici KTU05-7, P. pentosaceus KTU05-9, L. sakei KTU05-6, on the quality and safety parameters of ready - to cook - minced pork (RCMP). Fermented JA additives reduced pH of the meat products and decreased water holding capacity (WHC) from 2.01 till 2.93 %. Concentrations of biogenic amines in RCMP with additives of the lactic acid bacteria (LAB) - fermented JA were significantly lower comparing with control sample. The number of pathogenic bacteria in artificially contaminated meat samples was significantly reduced in case of LAB-fermented JA additives. The highest antimicrobial activity was obtained using P. acidilactici fermented JA additives. The amounts of microbial pathogens E. coli and Ent. faecalis, S. aureus and Streptococcus spp. were determined 3.41, 3.38, 3,96 and 4.74 log CFU/g correspondingly, whereas without LAB-fermented JA additives were 8.94, 7.75, 8.82 and 8.58 log CFU/g, correspondingly. A possibility to improve sensory properties (flavor) of RCMP using LAB fermented JA additives was investigated. The composition of volatile compounds of RCMP without additive and with LAB-fermented JA additives was analyzed using gas chromatography-mass spectrometry (GC-MS). The results of sensory evaluation of meat products supplemented with fermented JA additives revealed specific odor, which is pleasant and acceptable for consumers might be explainable that LAB-fermented JA additives have shown considerable differences mainly due to the accumulation of volatiles such as toluene, ethylbenzene, decane, undecane, 2 methyl undecane. N-morpholinomethyl-isopropyl-sulfide, 6-undecilamine and N,N-dimethyl-1-pentadecanamine were not determined in RCMP with LAB-fermented JA additives. The results obtained show, that P. acidilactici fermented JA 5 % additive is most suitable for the RCMP processing in order to prevent microbiological spoilage, increase

Liftoff of STS-59 Shuttle Endeavour

NASA Image and Video Library

1994-04-09

STS059-S-036 (9 April 1994) --- The liftoff of the Space Shuttle Endeavour is backdropped against a dawn sky at the Kennedy Space Center (KSC) as six NASA astronauts head for a week and a half in Earth orbit. The morning sky allows for a contrasting backdrop for the diamond shock effect of the thrust from Endeavour's main engines. Liftoff occurred at 7:05 a.m. (EDT), April 9, 1994. Onboard for the Space Radar Laboratory (SRL-1) mission were astronauts Sidney M. Gutierrez, Kevin P. Chilton, Jerome (Jay) Apt, Linda M. Godwin, Michael R. U. (Rich) Clifford and Thomas D. Jones.

STS-37 MS Godwin balances MS Ross using her index finger on OV-104's middeck

NASA Image and Video Library

1991-04-11

STS037-29-002 (5-11 April 1991) --- Astronauts Linda M. Godwin and Jerry L. Ross perform a balancing act on Atlantis' middeck. With little effort Godwin is able to hold Ross up near the ceiling with her index finger. Although the area the two occupy is very small, a number of articles are seen, including two sleep restraints, the escape pole and Bioserve ITA Materials Dispersion Apparatus bioprocessing test bed (attached to stowage lockers at left). This was one of the visuals used by the STS-37 crewmembers during their April 19 post-flight press conference at the Johnson Space Center (JSC).

Space Science

NASA Image and Video Library

1991-01-28

This is the STS-37 Crew portrait. Pictured from left to right are Kenneth D. (Ken) Cameron, pilot; Jay Apt, mission specialist; Steven R. Nagel, commander; and Jerry L. Ross and Linda M. Godwin, mission specialists. Launched aboard the Space Shuttle Atlantis on April 5, 1991 at 9:22:44am (EST), the crew’s major objective was the deployment of the Gamma Ray Observatory (GRO). Included in the observatory were the Burst and Transient Source Experiment (BATSE); the Imaging Compton Telescope (COMPTEL); the Energetic Gamma Ray Experiment Telescope (EGRET); and the Oriented Scintillation Spectrometer Telescope (OSSEE).

Directed Molecular Evolution Improves the Immunogenicity and Protective Efficacy of a Venezuelan Equine Encephalitis Virus DNA Vaccine

DTIC Science & Technology

2009-05-01

p t S S 0 d Vaccine 27 (2009) 4152–4160 Contents lists available at ScienceDirect Vaccine...equine encephalitis virus DNA vaccine esley C. Dupuya,1, Christopher P . Locherc,1,2, Madan Paidhungatc,3, Michelle J. Richardsa, athleen M. Linda...a 8 s t d i t c w w i v i s s i i c f p a [ r p r V i w 2 2 I P L t g t b h i t c m s c T A L A A A A A L.C. Dupuy et al. / Vac ytomegalovirus

Flight deck activity during flyaround of Mir Space Station

NASA Image and Video Library

1996-04-19

STS076-316-008 (23 March 1996) --- On the aft flight deck of the Space Shuttle Atlantis, astronaut Linda M. Godwin uses a hand-held laser instrument to check the range of Russia's Mir Space Station during docking operations. The two spacecraft were in the process of making their third docking in Earth-orbit. With the subsequent delivery of astronaut Shannon W. Lucid to the Mir, the Mir-21 crew grew from two to three, as the mission specialist quickly becomes a cosmonaut guest researcher. Lucid will spend approximately 140 days on Mir before returning to Earth.

Sally Ride Women in Science Panel

NASA Image and Video Library

2013-05-17

Panel discussion participants, from left, Linda Billings, research professor, Media and Public Affairs, The George Washington University, Ellen Ochoa, director, NASA Johnson Space Center, Tom Costello, NBC News and moderator for the event, Margaret Weitekamp, space history curator, National Air and Space Museum, Dan Vergano, science writer for USA Today, and Rene McCormick, director of standards and quality, National Math and Science Initiative, are seen during a program titled "Sally Ride: How Her Historic Space Mission Opened Doors for Women in Science" held on Friday, May 17, 2013 at the National Air and Space Museum in Washington. Photo Credit: (NASA/Bill Ingalls)

Japanese apricot improves symptoms of gastrointestinal dysmotility associated with gastroesophageal reflux disease.

PubMed

Maekita, Takao; Kato, Jun; Enomoto, Shotaro; Yoshida, Takeichi; Utsunomiya, Hirotoshi; Hayashi, Hideyuki; Hanamitsu, Toshiko; Inoue, Izumi; Maeda, Yoshimasa; Moribata, Kosaku; Muraki, Yosuke; Shingaki, Naoki; Deguchi, Hisanobu; Ueda, Kazuki; Iguchi, Mikitaka; Tamai, Hideyuki; Ichinose, Masao

2015-07-14

To investigate the effects of Japanese apricot (JA) consumption on gastroesophageal reflux disease (GERD)-related symptoms. Participants included individuals living in Minabe-cho, a well-known JA-growing region, who received specific medical check-ups by the local community health service in 2010. GERD-related symptoms were examined in 1303 Japanese individuals using a validated questionnaire, the Frequency Scale for Symptoms of GERD (FSSG), which consists of 7 questions associated with acid reflux symptoms and 5 questions asking about gastrointestinal dysmotility symptoms. Each question was answered using a 4-point scale, with higher scores indicating more severe GERD-related symptoms. Subjects were divided into two groups according to their intake of dried and pickled JA: daily intake (≥ 1 JA daily) (392 subjects) and none or occasional intake (< 1 JA daily) (911 subjects). FSSG scores were compared between subjects who consumed JA daily and those who did not. Next, subjects were stratified by age, gender and Helicobacter pylori (H. pylori) status for subanalyses. Those who ate JA daily were significantly older than those who did not (60.6 ± 10.5 years vs 56.0 ± 11.0 years, P < 0.001). Total FSSG scores were significantly lower in subjects with daily JA intake than in those with none or only occasional intake (2.13 ± 3.14 vs 2.70 ± 3.82, P = 0.005). In particular, subjects who consumed JA daily showed significantly improved FSSG dysmotility scores compared with subjects who did not (1.05 ± 1.58 vs 1.46 ± 2.11, P < 0.001). In contrast, the FSSG reflux score did not differ between subjects with and without daily intake of JA (1.08 ± 1.90 vs 1.24 ± 2.11, P = 0.177). Subanalysis indicated that improvement in dysmotility by JA intake was specifically observed in non-elderly (1.24 ± 1.68 vs 1.62 ± 2.22, P = 0.005) and H. pylori-negative subjects (0.99 ± 1.58 vs 1.57 ± 2.06, P < 0.001). GERD patients (total FSSG score ≥ 8) were less frequently observed