Sample records for zymogenic chief cell

  1. Metaplastic Cells in the Stomach Arise, Independently of Stem Cells, via Dedifferentiation or Transdifferentiation of Chief Cells.

    PubMed

    Radyk, Megan D; Burclaff, Joseph; Willet, Spencer G; Mills, Jason C

    2018-03-01

    Spasmolytic polypeptide-expressing metaplasia (SPEM) develops in patients with chronic atrophic gastritis due to infection with Helicobacter pylori; it might be a precursor to intestinal metaplasia and gastric adenocarcinoma. Lineage tracing experiments of the gastric corpus in mice have not established whether SPEM derives from proliferating stem cells or differentiated, post-mitotic zymogenic chief cells in the gland base. We investigated whether differentiated cells can give rise to SPEM using a nongenetic approach in mice. Mice were given intraperitoneal injections of 5-fluorouracil, which blocked gastric cell proliferation, plus tamoxifen to induce SPEM. Based on analyses of molecular and histologic markers, we found SPEM developed even in the absence of cell proliferation. SPEM therefore did not arise from stem cells. In histologic analyses of gastric resection specimens from 10 patients with adenocarcinoma, we found normal zymogenic chief cells that were transitioning into SPEM cells only in gland bases, rather than the proliferative stem cell zone. Our findings indicate that SPEM can arise by direct reprogramming of existing cells-mainly of chief cells. Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.

  2. Proliferative capability of parietal and zymogen cells.

    PubMed Central

    Chen, K Y; Withers, H R

    1975-01-01

    Six to eight week old male mice of C3Hf/Bu strain were killed and studied at various times from 30 minutes to 30 days after tritiated thymidine (3H-TdR) injection. Labelling of parietal and zymogen cells was observed in autoradiographic histological specimens. There were 590 +/- 22 gastric glands per circumference at the body of the stomach. Parietal cells were counted as 16-2 (14-0-18-4) per gland or 9600 per circumference. There were 11-4 (9-4-13-7) zymogen cells per gland or 6700 per circumference. Two labelled immature parietal cells per circumference were seen 30 minutes after 3H-TdR injection, equivalent to a ratio of 1:5000; more mature labelled parietal cells were seen at later times up to 30 days. There was evidence for proliferation during maturation and downward migration of cells toward the body and the lower part of the gastric gland. Our data support earlier evidence that immature parietal cells constantly supply mature parietal cells through migration from a proliferative zone. Whether the parietal cells are derived from the same stem cell compartment as surface epithelium cells is unclear at the present time. An average of 2-6 zymogen cells per circumference, or 1:2500, was found to be labelled. While most zymogen cells were not proliferating, cells entered the proliferating cycle at random. Based on the findings reported in this paper and the radiation responses of both parietal and zymogen cells, it is postulated that they form part of a slow renewal system. Images Fig. 1 (cont.) Fig. 1 (cont.) Fig. 1 (cont.) Fig. 1 Fig. 2 (cont.) Fig. 2 (cont.) Fig. 2 PMID:1213947

  3. Alcohols enhance caerulein-induced zymogen activation in pancreatic acinar cells

    PubMed Central

    LU, ZHAO; KARNE, SURESH; KOLODECIK, THOMAS; GORELICK, FRED S.

    2010-01-01

    Activation of zymogens within the pancreatic acinar cell is an early feature of acute pancreatitis. Supraphysiological concentrations of cholecystokinin (CCK) cause zymogen activation and pancreatitis. The effects of the CCK analog, caerulein, and alcohol on trypsin and chymotrypsin activation in isolated pancreatic acini were examined. Caerulein increased markers of zymogen activation in a time- and concentration-dependent manner. Notably, trypsin activity reached a peak value within 30 min, then diminished with time, whereas chymotrypsin activity increased with time. Ethanol (35 mM) sensitized the acinar cells to the effects of caerulein (10−10 to 10−7 M) on zymogen activation but had no effect alone. The effects of ethanol were concentration dependent. Alcohols with a chain length of ≥2 also sensitized the acinar cell to caerulein; the most potent was butanol. Branched alcohols (2-propanol and 2-butanol) were less potent than aliphatic alcohols (1-propanol and 1-butanol). The structure of an alcohol is related to its ability to sensitize acinar cells to the effects of caerulein on zymogen activation. PMID:11842000

  4. The origin of pre-neoplastic metaplasia in the stomach: Chief cells emerge from the Mist

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Goldenring, James R., E-mail: jim.goldenring@vanderbilt.edu; Departments of Surgery and Cell and Developmental Biology, Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, TN; Nam, Ki Taek

    2011-11-15

    The digestive-enzyme secreting, gastric epithelial chief (zymogenic) cell is remarkable and underappreciated. Here, we discuss how all available evidence suggests that mature chief cells in the adult, mammalian stomach are postmitotic, slowly turning over cells that arise via a relatively long-lived progenitor, the mucous neck cell, The differentiation of chief cells from neck cells does not involve cell division, and the neck cell has its own distinct pattern of gene expression and putative physiological function. Thus, the ontogeny of the normal chief cell lineage exemplifies transdifferentiation. Furthermore, under pathophysiogical loss of acid-secreting parietal cell, the chief cell lineage can itselfmore » trasndifferentiate into a mucous cell metaplasia designated Spasmolytic Polypeptide Expressing Metaplasia (SPEM). Especially in the presence of inflammation, this metaplastic lineage can regain proliferative capacity and, in humans may also further differentiate into intestinal metaplasia. The results indicate that gastric fundic lineages display remarkable plasticity in both physiological ontogeny and pathophysiological pre-neoplastic metaplasia.« less

  5. Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury.

    PubMed

    Grady, T; Mah'Moud, M; Otani, T; Rhee, S; Lerch, M M; Gorelick, F S

    1998-11-01

    The pathological activation of digestive zymogens within the pancreatic acinar cell probably plays a central role in initiating many forms of pancreatitis. To examine the relationship between zymogen activation and acinar cell injury, we investigated the effects of secretagogue treatment on isolated pancreatic acini. Immunofluorescence studies using antibodies to the trypsinogen-activation peptide demonstrated that both CCK (10(-7) M) hyperstimulation and bombesin (10(-5) M) stimulation of isolated acini resulted in trypsinogen processing to trypsin. These treatments also induced the proteolytic processing of procarboxypeptidase A1 to carboxypeptidase A1 (CA1). After CCK hyperstimulation, most CA1 remained in the acinar cell. In contrast, the CA1 generated by bombesin was released from the acinar cell. CCK hyperstimulation of acini was associated with cellular injury, whereas bombesin treatment did not induce injury. These studies suggest that 1) proteolytic zymogen processing occurs within the pancreatic acinar cell and 2) both zymogen activation and the retention of enzymes within the acinar cell may be required to induce injury.

  6. Isolation of zymogen granules from rat pancreas.

    PubMed

    Rindler, Michael J

    2006-01-01

    This unit describes methods for preparing zymogen granules from rat pancreas. Zymogen granules are storage organelles in pancreatic acinar cells containing digestive enzymes that are released into the pancreatic duct. The protocols in this unit take advantage of the large size (up to 1 microm diameter) and high density (>1.20 g/cm(3) on sucrose gradients) of the granules as compared to other cellular organelles. They use a combination of differential sedimentation and density gradient separation to accomplish the purification. Similar procedures can be used to isolate zymogen granules from mouse pancreas and canine pancreas. A protocol for preparing zymogen granules from dog pancreas is also included.

  7. Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injury.

    PubMed

    Muili, Kamaldeen A; Ahmad, Mahwish; Orabi, Abrahim I; Mahmood, Syeda M; Shah, Ahsan U; Molkentin, Jeffery D; Husain, Sohail Z

    2012-04-15

    Acute pancreatitis is a major health burden for which there are currently no targeted therapies. Premature activation of digestive proenzymes, or zymogens, within the pancreatic acinar cell is an early and critical event in this disease. A high-amplitude, sustained rise in acinar cell Ca(2+) is required for zymogen activation. We previously showed in a cholecystokinin-induced pancreatitis model that a potential target of this aberrant Ca(2+) signaling is the Ca(2+)-activated phosphatase calcineurin (Cn). However, in this study, we examined the role of Cn on both zymogen activation and injury, in the clinically relevant condition of neurogenic stimulation (by giving the acetylcholine analog carbachol) using three different Cn inhibitors or Cn-deficient acinar cells. In freshly isolated mouse acinar cells, pretreatment with FK506, calcineurin inhibitory peptide (CiP), or cyclosporine (CsA) blocked intra-acinar zymogen activation (n = 3; P < 0.05). The Cn inhibitors also reduced leakage of lactate dehydrogenase (LDH) by 79%, 62%, and 63%, respectively (n = 3; P < 0.05). Of the various Cn isoforms, the β-isoform of the catalytic A subunit (CnAβ) was strongly expressed in mouse acinar cells. For this reason, we obtained acinar cells from CnAβ-deficient mice (CnAβ-/-) and observed an 84% and 50% reduction in trypsin and chymotrypsin activation, respectively, compared with wild-type controls (n = 3; P < 0.05). LDH release in the CnAβ-deficient cells was reduced by 50% (n = 2; P < 0.05). The CnAβ-deficient cells were also protected against zymogen activation and cell injury induced by the cholecystokinin analog caerulein. Importantly, amylase secretion was generally not affected by either the Cn inhibitors or Cn deficiency. These data provide both pharmacological and genetic evidence that implicates Cn in intra-acinar zymogen activation and cell injury during pancreatitis.

  8. Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injury

    PubMed Central

    Muili, Kamaldeen A.; Ahmad, Mahwish; Orabi, Abrahim I.; Mahmood, Syeda M.; Shah, Ahsan U.; Molkentin, Jeffery D.

    2012-01-01

    Acute pancreatitis is a major health burden for which there are currently no targeted therapies. Premature activation of digestive proenzymes, or zymogens, within the pancreatic acinar cell is an early and critical event in this disease. A high-amplitude, sustained rise in acinar cell Ca2+ is required for zymogen activation. We previously showed in a cholecystokinin-induced pancreatitis model that a potential target of this aberrant Ca2+ signaling is the Ca2+-activated phosphatase calcineurin (Cn). However, in this study, we examined the role of Cn on both zymogen activation and injury, in the clinically relevant condition of neurogenic stimulation (by giving the acetylcholine analog carbachol) using three different Cn inhibitors or Cn-deficient acinar cells. In freshly isolated mouse acinar cells, pretreatment with FK506, calcineurin inhibitory peptide (CiP), or cyclosporine (CsA) blocked intra-acinar zymogen activation (n = 3; P < 0.05). The Cn inhibitors also reduced leakage of lactate dehydrogenase (LDH) by 79%, 62%, and 63%, respectively (n = 3; P < 0.05). Of the various Cn isoforms, the β-isoform of the catalytic A subunit (CnAβ) was strongly expressed in mouse acinar cells. For this reason, we obtained acinar cells from CnAβ-deficient mice (CnAβ−/−) and observed an 84% and 50% reduction in trypsin and chymotrypsin activation, respectively, compared with wild-type controls (n = 3; P < 0.05). LDH release in the CnAβ-deficient cells was reduced by 50% (n = 2; P < 0.05). The CnAβ-deficient cells were also protected against zymogen activation and cell injury induced by the cholecystokinin analog caerulein. Importantly, amylase secretion was generally not affected by either the Cn inhibitors or Cn deficiency. These data provide both pharmacological and genetic evidence that implicates Cn in intra-acinar zymogen activation and cell injury during pancreatitis. PMID:22323127

  9. Intracellular proteolysis of pancreatic zymogens.

    PubMed Central

    Gorelick, F. S.; Modlin, I. M.; Leach, S. D.; Carangelo, R.; Katz, M.

    1992-01-01

    Activation of pancreatic digestive zymogens within the pancreatic acinar cell may be an early event in the development of pancreatitis. To detect such activation, an immunoblot assay has been developed that measures the relative amounts of inactive zymogens and their respective active enzyme forms. Using this assay, high doses of cholecystokinin or carbachol were found to stimulate the intracellular conversion of at least three zymogens (procarboxypeptidase A1, procarboxypeptidase B, and chymotrypsinogen 2) to their active forms. Thus, this conversion may be a generalized phenomenon of pancreatic zymogens. The conversion is detected within ten minutes of treatment and is not associated with changes in acinar cell morphology; it has been predicted that the lysosomal thiol protease, cathepsin B, may initiate this conversion. Small amounts of cathepsin B are found in the secretory pathway, and cathepsin B can activate trypsinogen in vitro; however, exposure of acini to a thiol protease inhibitor (E64) did not block this conversion. Conversion was inhibited by the serine protease inhibitor, benzamidine, and by raising the intracellular pH, using chloroquine or monensin. This limited proteolytic conversion appears to require a low pH compartment and a serine protease activity. After long periods of treatment (60 minutes), the amounts of the active enzyme forms began to decrease; this observation suggested that the active enzyme forms were being degraded. Treatment of acini with E64 reduced this late decrease in active enzyme forms, suggesting that thiol proteases, including lysosomal hydrolases, may be involved in the degradation of the active enzyme forms. These findings indicate that pathways for zymogen activation as well as degradation of active enzyme forms are present within the pancreatic acinar cell. Images FIG. 1 FIG. 6 PMID:1340058

  10. Intracellular activation of digestive zymogens in rat pancreatic acini. Stimulation by high doses of cholecystokinin.

    PubMed Central

    Leach, S D; Modlin, I M; Scheele, G A; Gorelick, F S

    1991-01-01

    The mechanism by which digestive zymogens become activated during acute pancreatitis remains poorly understood. Given the ability for cholecystokinin (CCK) to induce pancreatitis in vivo, the effects of high dose CCK on preparations of isolated pancreatic acini were examined. Using an immunologic technique for the detection of zymogen activation, CCK was found to stimulate the conversion of procarboxypeptidase A1 to a 35-kD form having the same net charge and electrophoretic mobility as purified recombinant carboxypeptidase A1. This enhanced conversion was proportional to the dose of CCK (maximal at 100 nM), and time dependent. CCK also produced changes in the electrophoretic mobility of procarboxypeptidase B and chymotrypsinogen 2 immunoreactivity, consistent with activation of these zymogens. These events were detectable only within acinar cell pellets and not in the incubation medium, suggesting an intracellular site of conversion. The conversion of procarboxypeptidase A1 to its active form was inhibited by pretreatment with the weak base chloroquine (40 microM) and the protonophore monensin (10 microM). This conversion was also inhibited by pretreatment with the serine protease inhibitor benzamidine (10 mM) but not the cysteine protease inhibitor E64 (100 microM). The results suggest that high dose CCK stimulates the intracellular activation of digestive zymogens within isolated pancreatic acini. This event appears to require an acidic subcellular compartment and serine protease activity. Images PMID:1985109

  11. Roles of CUB and LDL receptor class A domain repeats of a transmembrane serine protease matriptase in its zymogen activation

    PubMed Central

    Inouye, Kuniyo; Tomoishi, Marie; Yasumoto, Makoto; Miyake, Yuka; Kojima, Kenji; Tsuzuki, Satoshi; Fushiki, Tohru

    2013-01-01

    Matriptase is a type II transmembrane serine protease containing two complement proteases C1r/C1s–urchin embryonic growth factor–bone morphogenetic protein domains (CUB repeat) and four low-density lipoprotein receptor class A domains (LDLRA repeat). The single-chain zymogen of matriptase has been found to exhibit substantial protease activity, possibly causing its own activation (i.e. conversion to a disulfide-linked two-chain fully active form), although the activation seems to be mediated predominantly by two-chain molecules. Our aim was to assess the roles of CUB and LDLRA repeats in zymogen activation. Transient expression studies of soluble truncated constructs of recombinant matriptase in COS-1 cells showed that the CUB repeat had an inhibitory effect on zymogen activation, possibly because it facilitated the interaction of two-chain molecules with a matriptase inhibitor, hepatocyte growth factor activator inhibitor type-1. By contrast, the LDLRA repeat had a promoting effect on zymogen activation. The effect of the LDLRA repeat seems to reflect its ability to increase zymogen activity. The proteolytic activities were higher in pseudozymogen forms of recombinant matriptase containing the LDLRA repeat than in a pseudozymogen without the repeat. Our findings provide new insights into the roles of these non-catalytic domains in the generation of active matriptase. PMID:23038671

  12. Identification of SNAREs that mediate zymogen granule exocytosis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pickett, James A.; Campos-Toimil, Manuel; Thomas, Paul

    2007-08-03

    A secretagogue-stimulated pancreatic acinar cell releases digestive enzymes from its apical pole. We attempted to identify the SNAREs involved in zymogen granule exocytosis. Antibodies against syntaxins 2 and 3, SNAP-23 and VAMP 8, and the corresponding recombinant SNAREs, inhibited amylase secretion from streptolysin O-permeabilised acini; other anti-SNARE antibodies and SNAREs had no effect. Botulinum neurotoxin C, which cleaved syntaxin 2 and (to a lesser extent) syntaxin 3, but not syntaxins 4, 7 or 8, also inhibited exocytosis. We propose that syntaxin 2, SNAP-23 and VAMP 8 mediate primary granule-plasma membrane fusion. Syntaxin 3 may be involved in secondary granule-granule fusion.

  13. Structure and dynamics of zymogen human blood coagulation factor X.

    PubMed

    Venkateswarlu, Divi; Perera, Lalith; Darden, Tom; Pedersen, Lee G

    2002-03-01

    The solution structure and dynamics of the human coagulation factor X (FX) have been investigated to understand the key structural elements in the zymogenic form that participates in the activation process. The model was constructed based on the 2.3-A-resolution x-ray crystallographic structure of active-site inhibited human FXa (PDB:1XKA). The missing gamma-carboxyglutamic acid (GLA) and part of epidermal growth factor 1 (EGF1) domains of the light chain were modeled based on the template of GLA-EGF1 domains of the tissue factor (TF)-bound FVIIa structure (PDB:1DAN). The activation peptide and other missing segments of FX were introduced using homology modeling. The full calcium-bound model of FX was subjected to 6.2 ns of molecular dynamics simulation in aqueous medium using the AMBER6.0 package. We observed significant reorientation of the serine-protease (SP) domain upon activation leading to a compact multi-domain structure. The solution structure of zymogen appears to be in a well-extended conformation with the distance between the calcium ions in the GLA domain and the catalytic residues estimated to be approximately 95 A in contrast to approximately 83 A in the activated form. The latter is in close agreement with fluorescence studies on FXa. The S1-specificity residues near the catalytic triad show significant differences between the zymogen and activated structures.

  14. Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity

    PubMed Central

    Barndt, Robert; Gu, Yayun; Chen, Chien-Yu; Tseng, I-Chu; Su, Sheng-Fang; Wang, Jehng-Kang; Johnson, Michael D.

    2017-01-01

    The type 2 transmembrane serine protease matriptase is involved in many pathophysiological processes probably via its enzymatic activity, which depends on the dynamic relationship between zymogen activation and protease inhibition. Matriptase shedding can prolong the life of enzymatically active matriptase and increase accessibility to substrates. We show here that matriptase shedding occurs via a de novo proteolytic cleavage at sites located between the SEA domain and the CUB domain. Point or combined mutations at the four positively charged amino acid residues in the region following the SEA domain allowed Arg-186 to be identified as the primary cleavage site responsible for matriptase shedding. Kinetic studies further demonstrate that matriptase shedding is temporally coupled with matriptase zymogen activation. The onset of matriptase shedding lags one minute behind matriptase zymogen activation. Studies with active site triad Ser-805 point mutated matriptase, which no longer undergoes zymogen activation or shedding, further suggests that matriptase shedding depends on matriptase zymogen activation, and that matriptase proteolytic activity may be involved in its own shedding. Our studies uncover an autonomous mechanism coupling matriptase zymogen activation, proteolytic activity, and shedding such that a proportion of newly generated active matriptase escapes HAI-1-mediated rapid inhibition by shedding into the extracellular milieu. PMID:28829816

  15. Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation.

    PubMed

    Scannevin, Robert H; Alexander, Richard; Haarlander, Tara Mezzasalma; Burke, Sharon L; Singer, Monica; Huo, Cuifen; Zhang, Yue-Mei; Maguire, Diane; Spurlino, John; Deckman, Ingrid; Carroll, Karen I; Lewandowski, Frank; Devine, Eric; Dzordzorme, Keli; Tounge, Brett; Milligan, Cindy; Bayoumy, Shariff; Williams, Robyn; Schalk-Hihi, Celine; Leonard, Kristi; Jackson, Paul; Todd, Matthew; Kuo, Lawrence C; Rhodes, Kenneth J

    2017-10-27

    Aberrant activation of matrix metalloproteinases (MMPs) is a common feature of pathological cascades observed in diverse disorders, such as cancer, fibrosis, immune dysregulation, and neurodegenerative diseases. MMP-9, in particular, is highly dynamically regulated in several pathological processes. Development of MMP inhibitors has therefore been an attractive strategy for therapeutic intervention. However, a long history of failed clinical trials has demonstrated that broad-spectrum MMP inhibitors have limited clinical utility, which has spurred the development of inhibitors selective for individual MMPs. Attaining selectivity has been technically challenging because of sequence and structural conservation across the various MMPs. Here, through a biochemical and structural screening paradigm, we have identified JNJ0966, a highly selective compound that inhibited activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. JNJ0966 had no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and did not inhibit activation of the highly related MMP-2 zymogen. The molecular basis for this activity was characterized as an interaction of JNJ0966 with a structural pocket in proximity to the MMP-9 zymogen cleavage site near Arg-106, which is distinct from the catalytic domain. JNJ0966 was efficacious in reducing disease severity in a mouse experimental autoimmune encephalomyelitis model, demonstrating the viability of this therapeutic approach. This discovery reveals an unprecedented pharmacological approach to MMP inhibition, providing an opportunity to improve selectivity of future clinical drug candidates. Targeting zymogen activation in this manner may also allow for pharmaceutical exploration of other enzymes previously viewed as intractable drug targets. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  16. Corin mutations K317E and S472G from preeclamptic patients alter zymogen activation and cell surface targeting. [Corrected].

    PubMed

    Dong, Ningzheng; Zhou, Tiantian; Zhang, Yue; Liu, Meng; Li, Hui; Huang, Xiaoyi; Liu, Zhenzhen; Wu, Yi; Fukuda, Koichi; Qin, Jun; Wu, Qingyu

    2014-06-20

    Corin is a membrane-bound serine protease that acts as the atrial natriuretic peptide (ANP) convertase in the heart. Recent studies show that corin also activates ANP in the pregnant uterus to promote spiral artery remodeling and prevent pregnancy-induced hypertension. Two CORIN gene mutations, K317E and S472G, were identified in preeclamptic patients and shown to have reduced activity in vitro. In this study, we carried out molecular modeling and biochemical experiments to understand how these mutations impair corin function. By molecular modeling, the mutation K317E was predicted to alter corin LDL receptor-2 module conformation. Western blot analysis of K317E mutant in HEK293 cells showed that the mutation did not block corin expression on the cell surface but inhibited corin zymogen activation. In contrast, the mutation S472G was predicted to abolish a β-sheet critical for corin frizzled-2 module structure. In Western blot analysis and flow cytometry, S472G mutant was not detected on the cell surface in transfected HEK293 cells. By immunostaining, the S472G mutant was found in the ER, indicating that the mutation S472G disrupted the β-sheet, causing corin misfolding and ER retention. Thus, these results show that mutations in the CORIN gene may impair corin function by entirely different mechanisms. Together, our data provide important insights into the molecular basis underlying corin mutations that may contribute to preeclampsia in patients. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  17. Early to Late Endosome Trafficking Controls Secretion and Zymogen Activation in Rodent and Human Pancreatic Acinar Cells.

    PubMed

    Messenger, Scott W; Thomas, Diana Dh; Cooley, Michelle M; Jones, Elaina K; Falkowski, Michelle A; August, Benjamin K; Fernandez, Luis A; Gorelick, Fred S; Groblewski, Guy E

    2015-11-01

    Pancreatic acinar cells have an expanded apical endosomal system, the physiological and pathophysiological significance of which is still emerging. Phosphatidylinositol-3,5-bisphosphate (PI(3,5)P 2 ) is an essential phospholipid generated by PIKfyve, which phosphorylates phosphatidylinositol-3-phosphate (PI(3)P). PI(3,5)P 2 is necessary for maturation of early endosomes (EE) to late endosomes (LE). Inhibition of EE to LE trafficking enhances anterograde endosomal trafficking and secretion at the plasma membrane by default through a recycling endosome (RE) intermediate. We assessed the effects of modulating PIKfyve activity on apical trafficking and pancreatitis responses in pancreatic acinar cells. Inhibition of EE to LE trafficking was achieved using pharmacological inhibitors of PIKfyve, expression of dominant negative PIKfyve K1877E, or constitutively active Rab5-GTP Q79L. Anterograde endosomal trafficking was manipulated by expression of constitutively active and dominant negative Rab11a mutants. The effects of these agents on secretion, endolysosomal exocytosis of lysosome associated membrane protein (LAMP1), and trypsinogen activation in response to high-dose CCK-8, bile acids and cigarette toxin was determined. PIKfyve inhibition increased basal and stimulated secretion. Adenoviral overexpression of PIKfyve decreased secretion leading to cellular death. Expression of Rab5-GTP Q79L or Rab11a-GTP Q70L enhanced secretion. Conversely, dominant-negative Rab11a-GDP S25N reduced secretion. High-dose CCK inhibited endolysosomal exocytosis that was reversed by PIKfyve inhibition. PIKfyve inhibition blocked intracellular trypsin accumulation and cellular damage responses to high CCK-8, tobacco toxin, and bile salts in both rodent and human acini. These data demonstrate that EE-LE trafficking acutely controls acinar secretion and the intracellular activation of zymogens leading to the pathogenicity of acute pancreatitis.

  18. The Zymogen-Enteropeptidase System: A Practical Approach to Study the Regulation of Enzyme Activity by Proteolytic Cleavage

    ERIC Educational Resources Information Center

    Pizauro, Joao M., Jr.; Ferro, Jesus A.; de Lima, Andrea C. F.; Routman, Karina S.; Portella, Maria Celia

    2004-01-01

    The present research describes an efficient procedure to obtain high levels of trypsinogen and chymotrypsinogen by using a simple, rapid, and easily reproducible method. The extraction process and the time-course of activation of zymogens can be carried out in a single laboratory period, without sophisticated equipment. The main objective was to…

  19. Chief Information Officer > Library

    Science.gov Websites

    Skip to main content (Press Enter). Toggle navigation Chief Information Officer Search Search Chief Information Officer: Search Search Chief Information Officer: Search Chief Information Officer U.S. Department of Defense Chief Information Officer Home About DoD CIO Bios Organization DCIO C4&IIC DCIO IE

  20. Kashlev Named First Deputy Chief, GRCBL | Poster

    Cancer.gov

    By Nancy Parrish, Staff Writer Editor’s note: The text for this article was adapted from an e-mail announcement to the Center for Cancer Research community from Robert Wiltrout, Ph.D., on September 8, 2014. Robert Wiltrout, Ph.D., director, NCI Center for Cancer Research (CCR), recently announced the appointment of Mikhail Kashlev, Ph.D., to deputy chief of the Gene Regulation and Chromosome Biology Laboratory (GRCBL). The first deputy chief to be named in the GRCBL, Kashlev joins Jeff Strathern, Ph.D., GRCBL chief, in leading the laboratory in an active research environment that focuses on chromosome dynamics (recombination, chromosome segregation, and transposable elements) and regulation (transcription, silencing, and cell cycle control).

  1. TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa

    PubMed Central

    Quante, Michael; Marrache, Frederic; Goldenring, James R.; Wang, Timothy C.

    2010-01-01

    Background and Aims Gastric stem cells are located in the isthmus of the gastric glands, and give rise to epithelial progenitors that undergo bipolar migration and differentiation into pit and oxyntic lineages. While gastric mucus neck cells, located below the isthmus, express trefoil factor family 2 (TFF2) protein, TFF2 mRNA transcripts are concentrated in cells above the neck region in normal corpus mucosa, suggesting that TFF2 transcription is a marker of gastric progenitor cells. Methods Using a BAC strategy, we generated a transgenic mouse with a tamoxifen-inducible Cre under the control of the TFF2 promoter (TFF2-BAC-CreERT2) and analyzed the lineage derivation from TFF2 mRNA transcript-expressing (TTE) cells. Results TTE cells were localized to the isthmus, above and distinct from TFF2 protein-expressing mucus neck cells. Lineage tracing revealed that these cells migrated towards the bottom of the gland within 20 days, giving rise to parietal, mucous neck and chief cells, but not to ECL cells. Surface mucus cells were not derived from TTE cells, and the progeny of the TTE lineage did not survive beyond 200 days. TTE cells were localized in the isthmus adjacent to Dclk1+ putative progenitor cells. Induction of spasmolytic polypeptide-expressing metaplasia (SPEM) with DMP-777-induced acute parietal cell loss revealed that this metaplastic phenotype might arise in part through transdiferentiation of chief cells as opposed to expansion of mucus neck or progenitor cells. Conclusion TFF2-transcript-expressing cells are progenitors for mucus neck, parietal and zymogenic, but not for pit or ECL cell lineages in the oxyntic gastric mucosa. PMID:20708616

  2. 12 CFR 1710.17 - Certification of disclosures by chief executive officer and chief financial officer.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... officer and chief financial officer. 1710.17 Section 1710.17 Banks and Banking OFFICE OF FEDERAL HOUSING... Corporate Practices and Procedures § 1710.17 Certification of disclosures by chief executive officer and chief financial officer. The chief executive officer and the chief financial officer of an Enterprise...

  3. Joint Chiefs of Staff > Media > News

    Science.gov Websites

    Facebook on Flickr Joint Chiefs Army Chief of Staff Marine Corps Commandant Chief of Naval Operations Air Force Chief of Staff Chief of National Guard Bureau Biographies Directorates Directorates of Management Readout of Chairman of the Joint Chiefs of Staff Gen. Dunford's Meeting with Chief of the Turkish General

  4. Joint Chiefs of Staff > Media > Speeches

    Science.gov Websites

    Facebook on Flickr Joint Chiefs Army Chief of Staff Marine Corps Commandant Chief of Naval Operations Air Force Chief of Staff Chief of National Guard Bureau Biographies Directorates Directorates of Management introduce you to somebody. Right there is the chief of staff of the Air Force. Now, why am I - why am I

  5. Gastric adenocarcinoma with chief cell differentiation: a proposal for reclassification as oxyntic gland polyp/adenoma.

    PubMed

    Singhi, Aatur D; Lazenby, Audrey J; Montgomery, Elizabeth A

    2012-07-01

    Gastric adenocarcinoma with chief cell differentiation (GA-CCD) has been reported as a new, rare variant of gastric adenocarcinoma. Only 12 cases in Japanese patients have been described to date, but they demonstrate distinct clinicopathologic features. To further characterize these lesions, we have collected 10 additional cases. Patients ranged in age from 44 to 79 years (mean, 64.2 y) with a relatively equal sex distribution (6 women and 4 men). Stratified by race, 4 patients were Hispanic, 2 were White, 2 were African American, 1 was Asian (Chinese), and the race was unknown for 1 patient. All patients presented with gastroesophageal reflux that prompted an endoscopic examination. The majority of GA-CCDs were identified in the fundus (7 of 10, 70%) and the remaining in the cardia (n=3). Grossly, they were solitary and polypoid, ranging in size from 0.2 to 0.8 cm (mean, 0.4 cm). Histologically, all cases were centered in the deep mucosa, with focal involvement of surface foveolar epithelium in 3 (30%) cases but not the submucosa. The tumors consisted of clustered glands and irregular branching cords of oxyntic epithelium. Thin wisps of radiating smooth muscle separated the epithelium, but desmoplasia was distinctly absent in all cases. The oxyntic mucosa was 1 to 2 cells thick and composed of a mixture of mucous neck, parietal, and chief cells. In 7 of 10 (70%) cases, chief cells were the predominant cell type, whereas the remaining 3 cases consisted primarily of mucous neck cells. The nuclei were mildly enlarged with slight nuclear pleomorphism, but no mitotic figures were identified. In addition, necrosis, lymphovascular invasion, and perineural invasion were absent. Immunohistochemically, GA-CCDs were diffusely positive for MUC6 (10 of 10, 100%) and negative for MUC5AC (0%) and MUC2 (0%). Ki-67 immunolabeling demonstrated variable expression, with the highest areas ranging from 0.2% to 10%. Clinical follow-up was available for 9 of 10 (90%) patients and ranged

  6. Joint Chiefs of Staff > Media > Publications

    Science.gov Websites

    Facebook on Flickr Joint Chiefs Army Chief of Staff Marine Corps Commandant Chief of Naval Operations Air Force Chief of Staff Chief of National Guard Bureau Biographies Directorates Directorates of Management - Upholding Our Oath SEAC's Publications Book | The Noncommissioned Officer and Petty Officer SEAC's Articles

  7. Chief Information Officer > DoDSection508

    Science.gov Websites

    Skip to main content (Press Enter). Toggle navigation Chief Information Officer Search Search Chief Information Officer: Search Search Chief Information Officer: Search Chief Information Officer U.S. Department of Defense Chief Information Officer Home About DoD CIO Bios Organization DCIO C4&IIC DCIO IE

  8. Chief Information Officer > In the News

    Science.gov Websites

    Skip to main content (Press Enter). Toggle navigation Chief Information Officer Search Search Chief Information Officer: Search Search Chief Information Officer: Search Chief Information Officer U.S. Department of Defense Chief Information Officer Home About DoD CIO Bios Organization DCIO C4&IIC DCIO IE

  9. Chief Information Officer > About DoD CIO

    Science.gov Websites

    Skip to main content (Press Enter). Toggle navigation Chief Information Officer Search Search Chief Information Officer: Search Search Chief Information Officer: Search Chief Information Officer U.S. Department of Defense Chief Information Officer Home About DoD CIO Bios Organization DCIO C4&IIC DCIO IE

  10. Current perspectives on chief residents in psychiatry.

    PubMed

    Warner, Christopher H; Rachal, James; Breitbach, Jill; Higgins, Michael; Warner, Carolynn; Bobo, William

    2007-01-01

    The authors examine qualitative data from outgoing chief residents in psychiatry from the 2004-2005 academic year to 1) determine common characteristics between programs, 2) examine the residents' perspectives on their experiences, and 3) determine their common leadership qualities. The authors sent out self-report surveys via e-mail to 89 outgoing chief residents who attended the APA/Lilly Chief Resident Executive Leadership Program. Fifty-three (60%) chief residents responded. Although most chief residents are senior residents, over 20% are in their third postgraduate year. Two-thirds of programs have more than one chief resident each year. Most chief residents believe that their "participating" leadership style, existing leadership skills, and interpersonal skills contributed to their overall positive experiences. Successfully performing duties as a chief resident entails functioning in a variety of roles and demands attention to leadership qualities of the individual. Developing existing leadership skills, clarifying expectations, and providing mentorship to chief residents will ensure successful transition into practice, and the advancement of the field of psychiatry.

  11. Owen Barwell - Chief Financial Officer | NREL

    Science.gov Websites

    Owen Barwell - Chief Financial Officer Owen Barwell - Chief Financial Officer A photo of Owen , analysis, and management. He previously served as the Acting Chief Financial Officer and Deputy Chief Financial Officer of the U.S. Department of Energy (DOE), where he was directly responsible for DOE's

  12. Highly Conserved Arg Residue of ERFNIN Motif of Pro-Domain is Important for pH-Induced Zymogen Activation Process in Cysteine Cathepsins K and L.

    PubMed

    Aich, Pulakesh; Biswas, Sampa

    2018-06-01

    Pro-domain of a cysteine cathepsin contains a highly conserved Ex 2 Rx 2 Fx 2 Nx 3 Ix 3 N (ERFNIN) motif. The zymogen structure of cathepsins revealed that the Arg(R) residue of the motif is a central residue of a salt-bridge/H-bond network, stabilizing the scaffold of the pro-domain. Importance of the arginine is also demonstrated in studies where a single mutation (Arg → Trp) in human lysosomal cathepsin K (hCTSK) is linked to a bone-related genetic disorder "Pycnodysostosis". In the present study, we have characterized in vitro Arg → Trp mutant of hCTSK and the same mutant of hCTSL. The R → W mutant of hCTSK revealed that this mutation leads to an unstable zymogen that is spontaneously activated and auto-proteolytically degraded rapidly. In contrast, the same mutant of hCTSL is sufficiently stable and has proteolytic activity almost like its wild-type counterpart; however it shows an altered zymogen activation condition in terms of pH, temperature and time. Far and near UV circular dichroism and intrinsic tryptophan fluorescence experiments have revealed that the mutation has minimal effect on structure of the protease hCTSL. Molecular modeling studies shows that the mutated Trp31 in hCTSL forms an aromatic cluster with Tyr23 and Trp30 leading to a local stabilization of pro-domain and supplements the loss of salt-bridge interaction mediated by Arg31 in wild-type. In hCTSK-R31W mutant, due to presence of a non-aromatic Ser30 residue such interaction is not possible and may be responsible for local instability. These differences may cause detrimental effects of R31W mutation on the regulation of hCTSK auto-activation process compared to altered activation process in hCTSL.

  13. Modeling strength data for CREW CHIEF

    NASA Technical Reports Server (NTRS)

    Mcdaniel, Joe W.

    1990-01-01

    The Air Force has developed CREW CHIEF, a computer-aided design (CAD) tool for simulating and evaluating aircraft maintenance to determine if the required activities are feasible. CREW CHIEF gives the designer the ability to simulate maintenance activities with respect to reach, accessibility, strength, hand tool operation, and materials handling. While developing the CREW CHIEF, extensive research was performed to describe workers strength capabilities for using hand tools and manual handling of objects. More than 100,000 strength measures were collected and modeled for CREW CHIEF. These measures involved both male and female subjects in the 12 maintenance postures included in CREW CHIEF. The data collection and modeling effort are described.

  14. 7 CFR 1700.27 - Chief of Staff.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 11 2014-01-01 2014-01-01 false Chief of Staff. 1700.27 Section 1700.27 Agriculture... GENERAL INFORMATION Agency Organization and Functions § 1700.27 Chief of Staff. The Chief of Staff aids and assists the Administrator and the Deputy Administrator. The Chief of Staff advises the...

  15. 7 CFR 1700.27 - Chief of Staff.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 11 2012-01-01 2012-01-01 false Chief of Staff. 1700.27 Section 1700.27 Agriculture... GENERAL INFORMATION Agency Organization and Functions § 1700.27 Chief of Staff. The Chief of Staff aids and assists the Administrator and the Deputy Administrator. The Chief of Staff advises the...

  16. 7 CFR 1700.27 - Chief of Staff.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 11 2011-01-01 2011-01-01 false Chief of Staff. 1700.27 Section 1700.27 Agriculture... GENERAL INFORMATION Agency Organization and Functions § 1700.27 Chief of Staff. The Chief of Staff aids and assists the Administrator and the Deputy Administrator. The Chief of Staff advises the...

  17. 7 CFR 1700.27 - Chief of Staff.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 11 2013-01-01 2013-01-01 false Chief of Staff. 1700.27 Section 1700.27 Agriculture... GENERAL INFORMATION Agency Organization and Functions § 1700.27 Chief of Staff. The Chief of Staff aids and assists the Administrator and the Deputy Administrator. The Chief of Staff advises the...

  18. 7 CFR 1700.27 - Chief of Staff.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Chief of Staff. 1700.27 Section 1700.27 Agriculture... GENERAL INFORMATION Agency Organization and Functions § 1700.27 Chief of Staff. The Chief of Staff aids and assists the Administrator and the Deputy Administrator. The Chief of Staff advises the...

  19. 17 CFR 200.22 - The Chief Accountant.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false The Chief Accountant. 200.22... § 200.22 The Chief Accountant. The Chief Accountant of the Commission is the principal adviser to the... administration of the federal securities laws. The Chief Accountant oversees the accounting profession's standard...

  20. 17 CFR 200.22 - The Chief Accountant.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false The Chief Accountant. 200.22... § 200.22 The Chief Accountant. The Chief Accountant of the Commission is the principal adviser to the... administration of the federal securities laws. The Chief Accountant oversees the accounting profession's standard...

  1. 17 CFR 200.22 - The Chief Accountant.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false The Chief Accountant. 200.22... § 200.22 The Chief Accountant. The Chief Accountant of the Commission is the principal adviser to the... administration of the federal securities laws. The Chief Accountant oversees the accounting profession's standard...

  2. 17 CFR 200.22 - The Chief Accountant.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false The Chief Accountant. 200.22... § 200.22 The Chief Accountant. The Chief Accountant of the Commission is the principal adviser to the... administration of the federal securities laws. The Chief Accountant oversees the accounting profession's standard...

  3. 17 CFR 200.22 - The Chief Accountant.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 3 2014-04-01 2014-04-01 false The Chief Accountant. 200.22... § 200.22 The Chief Accountant. The Chief Accountant of the Commission is the principal adviser to the... administration of the federal securities laws. The Chief Accountant oversees the accounting profession's standard...

  4. Isolation and functional studies of human fetal gastric epithelium in primary culture.

    PubMed

    Chailler, Pierre; Beaulieu, Jean-François; Ménard, Daniel

    2012-01-01

    Our understanding of gastric epithelial physiology in man is limited by the absence of normal or appropriate cancer cell lines that could serve as an in vitro model. Research mostly relied on primary culture of gastric epithelial cells of animal species, enriched with surface mucous cells, and devoid of glandular zymogenic chief cells. We successfully applied a new nonenzymatic procedure using Matrisperse Cell Recovery Solution to dissociate the entire epithelium from human fetal stomach. Cultures were generated by seeding multicellular aggregates prepared by mechanical fragmentation. We further demonstrate that this simple and convenient technique allows for the maintenance of heterogenous gastric epithelial primary cultures on plastic without a biological matrix as well as the persistence of viable chief cells able to synthesize and secrete gastric digestive enzymes, i.e., pepsinogen and gastric lipase. In wounding experiments, epithelial restitution occurred in serum-reduced conditions and was modulated by exogenous agents. This culture system is thus representative of the foveolus-gland axis and offers new perspectives to establish the influence of individual growth factors and extracellular matrix components as well as their combinatory effects on gastric epithelium homeostasis.

  5. 7 CFR 2.70 - Deputy Chief Economist.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Deputy Chief Economist. 2.70 Section 2.70 Agriculture... GENERAL OFFICERS OF THE DEPARTMENT Delegations of Authority by the Chief Economist § 2.70 Deputy Chief Economist. Pursuant to § 2.29, the following delegation of authority is made by the Chief Economist to the...

  6. Chitosan Nanoencapsulated Exogenous Trypsin Biomimics Zymogen-Like Enzyme in Fish Gastrointestinal Tract

    PubMed Central

    Singh, Arvind R.; Ferosekhan, S.; Kothari, Dushyant C.; Pal, Asim Kumar; Jadhao, Sanjay Balkrishna

    2013-01-01

    Exogenous proteolytic enzyme supplementation is required in certain disease conditions in humans and animals and due to compelling reasons on use of more plant protein ingredients and profitability in animal feed industry. However, limitations on their utility in diet are imposed by their pH specificity, thermolabile nature, inhibition due to a variety of factors and the possibility of intestinal damage. For enhancing the efficacy and safety of exogenous trypsin, an efficient chitosan (0.04%) nanoencapsulation-based controlled delivery system was developed. An experiment was conducted for 45 days to evaluate nanoencapsulated trypsin (0.01% and 0.02%) along with 0.02% bare trypsin and 0.4% chitosan nanoparticles against a control diet on productive efficiency (growth rate, feed conversion and protein efficiency ratio), organo-somatic indices, nutrient digestibility, tissue enzyme activities, hematic parameters and intestinal histology of the fish Labeo rohita. All the synthesized nanoparticles were of desired characteristics. Enhanced fish productive efficiency using nanoencapsulated trypsin over its bare form was noticed, which corresponded with enhanced (P<0.01) nutrient digestibility, activity of intestinal protease, liver and muscle tissue transaminases (alanine and aspartate) and dehydrogenases (lactate and malate), serum blood urea nitrogen and serum protein profile. Intestinal tissues of fish fed with 0.02% bare trypsin showed broadened, marked foamy cells with lipid vacuoles. However, villi were healthier in appearance with improved morphological features in fish fed with nanoencapsulated trypsin than with bare trypsin, and the villi were longer in fish fed with 0.01% nanoencapsulated trypsin than with 0.02% nanoencapsulated trypsin. The result of this premier experiment shows that nanoencapsulated trypsin mimics zymogen-like proteolytic activity via controlled release, and hence the use of 0.01% nanoencapsulated trypsin (in chitosan nanoparticles) over bare

  7. Chitosan nanoencapsulated exogenous trypsin biomimics zymogen-like enzyme in fish gastrointestinal tract.

    PubMed

    Kumari, Rakhi; Gupta, Subodh; Singh, Arvind R; Ferosekhan, S; Kothari, Dushyant C; Pal, Asim Kumar; Jadhao, Sanjay Balkrishna

    2013-01-01

    Exogenous proteolytic enzyme supplementation is required in certain disease conditions in humans and animals and due to compelling reasons on use of more plant protein ingredients and profitability in animal feed industry. However, limitations on their utility in diet are imposed by their pH specificity, thermolabile nature, inhibition due to a variety of factors and the possibility of intestinal damage. For enhancing the efficacy and safety of exogenous trypsin, an efficient chitosan (0.04%) nanoencapsulation-based controlled delivery system was developed. An experiment was conducted for 45 days to evaluate nanoencapsulated trypsin (0.01% and 0.02%) along with 0.02% bare trypsin and 0.4% chitosan nanoparticles against a control diet on productive efficiency (growth rate, feed conversion and protein efficiency ratio), organo-somatic indices, nutrient digestibility, tissue enzyme activities, hematic parameters and intestinal histology of the fish Labeo rohita. All the synthesized nanoparticles were of desired characteristics. Enhanced fish productive efficiency using nanoencapsulated trypsin over its bare form was noticed, which corresponded with enhanced (P<0.01) nutrient digestibility, activity of intestinal protease, liver and muscle tissue transaminases (alanine and aspartate) and dehydrogenases (lactate and malate), serum blood urea nitrogen and serum protein profile. Intestinal tissues of fish fed with 0.02% bare trypsin showed broadened, marked foamy cells with lipid vacuoles. However, villi were healthier in appearance with improved morphological features in fish fed with nanoencapsulated trypsin than with bare trypsin, and the villi were longer in fish fed with 0.01% nanoencapsulated trypsin than with 0.02% nanoencapsulated trypsin. The result of this premier experiment shows that nanoencapsulated trypsin mimics zymogen-like proteolytic activity via controlled release, and hence the use of 0.01% nanoencapsulated trypsin (in chitosan nanoparticles) over bare

  8. STAT5-glucocorticoid receptor interaction and MTF-1 regulate the expression of ZnT2 (Slc30a2) in pancreatic acinar cells

    PubMed Central

    Guo, Liang; Lichten, Louis A.; Ryu, Moon-Suhn; Liuzzi, Juan P.; Wang, Fudi; Cousins, Robert J.

    2010-01-01

    The exocrine pancreas plays an important role in endogenous zinc loss by regulating excretion into the intestinal tract and hence influences the dietary zinc requirement. The present experiments show that the zinc transporter ZnT2 (Slc30a2) is localized to the zymogen granules and that dietary zinc restriction in mice decreased the zinc concentration of zymogen granules and ZnT2 expression. Excess zinc given orally increased ZnT2 expression and was associated with increased pancreatic zinc accumulation. Rat AR42J acinar cells when induced into a secretory phenotype, using the glucocorticoid analog dexamethasone (DEX), exhibited increased ZnT2 expression and labile zinc as measured with a fluorophore. DEX administrated to mice also induced ZnT2 expression that accompanied a reduction of the pancreatic zinc content. ZnT2 promoter analyses identified elements required for responsiveness to zinc and DEX. Zinc regulation was traced to a MRE located downstream from the ZnT2 transcription start site. Responsiveness to DEX is produced by two upstream STAT5 binding sites that require the glucocorticoid receptor for activation. ZnT2 knockdown in the AR42J cells using siRNA resulted in increased cytoplasmic zinc and decreased zymogen granule zinc that further demonstrated that ZnT2 may mediate the sequestration of zinc into zymogen granules. We conclude, based upon experiments with intact mice and pancreatic acinar cells in culture, that ZnT2 participates in zinc transport into pancreatic zymogen granules through a glucocorticoid pathway requiring glucocorticoid receptor and STAT5, and zinc-regulated signaling pathways requiring MTF-1. The ZnT2 transporter appears to function in a physiologically responsive manner involving entero-pancreatic zinc trafficking. PMID:20133611

  9. Machiavelli and the chief resident.

    PubMed

    Raviglione, M C

    1990-06-01

    A good chief resident is under pressure from residents and the department director and must work for the welfare of both the housestaff and the institution. Using precepts from Niccoló Machiavelli's The Prince, the author gives advice for chief residents on how to balance their responsibilities. The author, using Machiavelli's precepts, discusses the difficulties of introducing change, supervising former colleagues and peers, the opprobrium that inevitably attaches to tough decisions, the need to set good examples, and other aspects of being a chief resident.

  10. 5 CFR 2421.10 - Chief Administrative Law Judge.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Chief Administrative Law Judge. 2421.10... § 2421.10 Chief Administrative Law Judge. Chief Administrative Law Judge means the Chief Administrative Law Judge of the Authority. ...

  11. Chief Information Officer > DoDSection508 > Std_Stmt

    Science.gov Websites

    Skip to main content (Press Enter). Toggle navigation Chief Information Officer Search Search Chief Information Officer: Search Search Chief Information Officer: Search Chief Information Officer U.S. Department of Defense Chief Information Officer Home About DoD CIO Bios Organization DCIO C4&IIC DCIO IE

  12. Chief Information Officer - U.S. Department of Defense

    Science.gov Websites

    Skip to main content (Press Enter). Toggle navigation Chief Information Officer Search Search Chief Information Officer: Search Search Chief Information Officer: Search Chief Information Officer U.S. Department of Defense Chief Information Officer Home About DoD CIO Bios Organization DCIO C4&IIC DCIO IE

  13. 22 CFR 1421.9 - Chief Administrative Law Judge.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Chief Administrative Law Judge. 1421.9 Section... OF TERMS AS USED IN THIS SUBCHAPTER § 1421.9 Chief Administrative Law Judge. Chief Administrative Law Judge means the Chief Administrative Law Judge of the Authority. ...

  14. 46 CFR 11.553 - Chief engineer (OSV).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Chief engineer (OSV). 11.553 Section 11.553 Shipping... OFFICER ENDORSEMENTS Professional Requirements for National Engineer Officer Endorsements § 11.553 Chief engineer (OSV). (a) The minimum service required to qualify an applicant for an endorsement as chief...

  15. Coleadership Among Chief Residents: Exploration of Experiences Across Specialties

    PubMed Central

    Pettit, Jeffrey E.

    2015-01-01

    Background Many departments have multiple chief residents. How these coleaders relate to each other could affect their performance, the residency program, and the department. Objective This article reports on how co-chiefs work together during the chief year, and what may allow them to be more effective coleaders. Methods A phenomenological research design was used to investigate experiences of outgoing chief residents from 13 specialties at the University of Iowa Hospitals and Clinics over a 2-year period from 2012 through 2013. Thematic analysis of semistructured interviews was conducted to investigate commonalities and recommendations. Results Face-to-face interviews with 19 chief residents from 13 different specialties identified experiences that helped co-chiefs work effectively with each other in orienting new co-chiefs, setting goals and expectations, making decisions, managing interpersonal conflict, leadership styles, communicating, working with program directors, and providing evaluations and feedback. Although the interviewed chief residents received guidance on how to be an effective chief resident, none had been given advice on how to effectively work with a co-chief, and 26% (5 of 19) of the respondents reported having an ineffective working relationship with their co-chief. Conclusions Chief residents often colead in carrying out their multiple functions. To successfully function in a multichief environment, chief residents may benefit from a formal co-orientation in which they discuss goals and expectations, agree on a decision-making process, understand each other's leadership style, and receive feedback on their efficacy as leaders. PMID:26221435

  16. Penny Burton - Chief Human Resources Officer | NREL

    Science.gov Websites

    Penny Burton - Chief Human Resources Officer Penny Burton - Chief Human Resources Officer A photo of Penny Burton. As chief human resources officer, Penny Burton is responsible for development of a human capital management system to more effectively manage NREL's workforce, all while achieving

  17. 32 CFR 536.11 - Chief of Engineers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 3 2013-07-01 2013-07-01 false Chief of Engineers. 536.11 Section 536.11 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY CLAIMS AND ACCOUNTS CLAIMS AGAINST THE UNITED STATES The Army Claims System § 536.11 Chief of Engineers. The Chief of Engineers...

  18. 32 CFR 536.11 - Chief of Engineers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 3 2011-07-01 2009-07-01 true Chief of Engineers. 536.11 Section 536.11 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY CLAIMS AND ACCOUNTS CLAIMS AGAINST THE UNITED STATES The Army Claims System § 536.11 Chief of Engineers. The Chief of Engineers...

  19. 46 CFR 11.553 - Chief Engineer (OSV).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Chief Engineer (OSV). 11.553 Section 11.553 Shipping... OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.553 Chief Engineer (OSV). (a) Except as provided by paragraph (b) of this section, to qualify for an endorsement as Chief engineer (OSV...

  20. 46 CFR 11.553 - Chief Engineer (OSV).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Chief Engineer (OSV). 11.553 Section 11.553 Shipping... OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.553 Chief Engineer (OSV). (a) Except as provided by paragraph (b) of this section, to qualify for an endorsement as Chief engineer (OSV...

  1. 32 CFR 536.11 - Chief of Engineers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 3 2012-07-01 2009-07-01 true Chief of Engineers. 536.11 Section 536.11 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY CLAIMS AND ACCOUNTS CLAIMS AGAINST THE UNITED STATES The Army Claims System § 536.11 Chief of Engineers. The Chief of Engineers...

  2. 32 CFR 536.11 - Chief of Engineers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Chief of Engineers. 536.11 Section 536.11 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY CLAIMS AND ACCOUNTS CLAIMS AGAINST THE UNITED STATES The Army Claims System § 536.11 Chief of Engineers. The Chief of Engineers...

  3. 32 CFR 536.11 - Chief of Engineers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 3 2014-07-01 2014-07-01 false Chief of Engineers. 536.11 Section 536.11 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY CLAIMS AND ACCOUNTS CLAIMS AGAINST THE UNITED STATES The Army Claims System § 536.11 Chief of Engineers. The Chief of Engineers...

  4. 46 CFR 11.553 - Chief Engineer (OSV).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Chief Engineer (OSV). 11.553 Section 11.553 Shipping... OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.553 Chief Engineer (OSV). (a) Except as provided by paragraph (b) of this section, to qualify for an endorsement as Chief engineer (OSV...

  5. 46 CFR 11.553 - Chief Engineer (OSV).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Chief Engineer (OSV). 11.553 Section 11.553 Shipping... OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.553 Chief Engineer (OSV). (a) Except as provided by paragraph (b) of this section, to qualify for an endorsement as Chief engineer (OSV...

  6. NASA chief scientist visit

    NASA Image and Video Library

    2011-07-19

    NASA Chief Scientist Dr. Waleed Abdalati visited Stennis Space Center on July 19, to learn about the extensive science capabilities onsite. Shown at right are: (seated, l to r), Stennis Center Director Patrick Scheuermann; Dr. Abdalati; U.S. Navy Rear Adm. Jonathan White; NOAA National Data Buoy Center Program Manager Shannon McArthur; (standing, l to r) Stennis Project Directorate Assistant Director Anne Peek; Stennis Applied Science & Technology Project Office Chief Duane Armstrong; and Stennis Project Directorate Director Keith Brock.

  7. Gen. Paul J. Selva > Joint Chiefs of Staff > Article View

    Science.gov Websites

    aircraft systems and executive officer, Deputy Chief of Staff, Plans and Resources, Headquarters Strategic Facebook on Flickr Joint Chiefs Army Chief of Staff Marine Corps Commandant Chief of Naval Operations Air Force Chief of Staff Chief of National Guard Bureau Biographies Directorates Directorates of Management

  8. Joint Chiefs of Staff > Directorates > J6 | C4 & Cyber

    Science.gov Websites

    the Joint Staff Chief Information Officer (CIO), the J-6 provides business class Information on Facebook on Flickr Joint Chiefs► Army Chief of Staff Marine Corps Commandant Chief of Naval Operations Air Force Chief of Staff Chief of National Guard Bureau Biographies Directorates Directorates of

  9. East bay fire chiefs' consortium

    Treesearch

    Michael Bradley

    1995-01-01

    The traditional approach to planning for public fire protection has been based on independent actions by each fire department or district. The county fire chiefs’ associations, while providing interagency communication, were not adequate to deal with the regional nature of the wildland urban interface problem. The formation of the East Bay Fire Chiefs’ Consortium grew...

  10. Joint Chiefs of Staff > Directorates > J2 | Joint Staff Intelligence

    Science.gov Websites

    on Facebook on Flickr Joint Chiefs► Army Chief of Staff Marine Corps Commandant Chief of Naval Operations Air Force Chief of Staff Chief of National Guard Bureau Biographies Directorates Directorates of

  11. Characteristics of a Bacteriocin Derived from Streptococcus faecalis var. zymogenes Antagonistic to Diplococcus peumoniae

    PubMed Central

    Bottone, Edward; Allerhand, Jona; Pisano, Michael A.

    1971-01-01

    A bacteriocin-producing strain of Streptococcus faecalis var. zymogenes (E-1) was isolated from clinical material (conjunctiva). The active substance differed from bacteriocins described by other investigators primarily in its spectrum of antibacterial activity, especially by its marked inhibition of Diplococcus pneumoniae. The E-1 bacteriocin also inhibited nonhemolytic strains of enterococci as well as one-third of the Viridans group of streptococcal strains investigated. The degree of inhibition, however, as indicated by the size of the zones against the latter organisms, was significantly reduced. No activity was detected against any of the strains belonging to the following groups of bacteria: hemolytic enterococci, beta-hemolytic streptococci, nonhemolytic streptococci, staphylococci, and various gram-negative species. Similarly, three strains each of Bacillus cereus and Listeria monocytogenes and one strain of Erysipelothrix insidiosa were not inhibited. The bacteriocin was able to diffuse through bacterial membranes as well as cellulose dialyzer tubing. It was inactivated by heating to 80 C for 20 min but resisted inactivation by either trypsin or chloroform. Images PMID:4398532

  12. An Investigation of Chief Administrator Turnover in International Schools

    ERIC Educational Resources Information Center

    Benson, John

    2011-01-01

    This article explores chief administrator turnover in international schools. Quantitative and qualitative data from the 83 chief administrators who participated in the study suggests that the average tenure of an international school chief administrator is 3.7 years and that the main reason chief administrators leave international schools is…

  13. 32 CFR 700.333 - The Chief of Naval Research.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false The Chief of Naval Research. 700.333 Section 700... The Office of the Secretary of the Navy/the Staff Assistants § 700.333 The Chief of Naval Research. (a) The Chief of Naval Research shall command the Office of the Chief of Naval Research, the Office of...

  14. 32 CFR 700.333 - The Chief of Naval Research.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false The Chief of Naval Research. 700.333 Section 700... The Office of the Secretary of the Navy/the Staff Assistants § 700.333 The Chief of Naval Research. (a) The Chief of Naval Research shall command the Office of the Chief of Naval Research, the Office of...

  15. 14 CFR 1212.703 - NASA Chief Information Officer.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false NASA Chief Information Officer. 1212.703 Section 1212.703 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS NASA Authority and Responsibilities § 1212.703 NASA Chief Information Officer. (a) The NASA Chief...

  16. Chief Information Officer > About DoD CIO > Organization > DCIO IE

    Science.gov Websites

    Skip to main content (Press Enter). Toggle navigation Chief Information Officer Search Search Chief Information Officer: Search Search Chief Information Officer: Search Chief Information Officer U.S. Department of Defense Chief Information Officer Home About DoD CIO Bios Organization DCIO C4&IIC DCIO IE

  17. 7 CFR 2.400 - Deputy Chief Information Officer.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Deputy Chief Information Officer. 2.400 Section 2.400... AND GENERAL OFFICERS OF THE DEPARTMENT Delegations of Authority by the Chief Information Officer § 2.400 Deputy Chief Information Officer. Pursuant to § 2.89, the following delegation of authority is...

  18. 7 CFR 2.400 - Deputy Chief Information Officer.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Deputy Chief Information Officer. 2.400 Section 2.400... AND GENERAL OFFICERS OF THE DEPARTMENT Delegations of Authority by the Chief Information Officer § 2.400 Deputy Chief Information Officer. Pursuant to § 2.89, the following delegation of authority is...

  19. 7 CFR 2.400 - Deputy Chief Information Officer.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Deputy Chief Information Officer. 2.400 Section 2.400... AND GENERAL OFFICERS OF THE DEPARTMENT Delegations of Authority by the Chief Information Officer § 2.400 Deputy Chief Information Officer. Pursuant to § 2.89, the following delegation of authority is...

  20. 7 CFR 2.200 - Deputy Chief Information Officer.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Deputy Chief Information Officer. 2.200 Section 2.200... AND GENERAL OFFICERS OF THE DEPARTMENT Delegations of Authority by the Chief Information Officer § 2.200 Deputy Chief Information Officer. Pursuant to § 2.37, the following delegation of authority is...

  1. 7 CFR 2.400 - Deputy Chief Information Officer.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Deputy Chief Information Officer. 2.400 Section 2.400... AND GENERAL OFFICERS OF THE DEPARTMENT Delegations of Authority by the Chief Information Officer § 2.400 Deputy Chief Information Officer. Pursuant to § 2.89, the following delegation of authority is...

  2. 46 CFR 15.820 - Chief engineer.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Chief engineer. 15.820 Section 15.820 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN MANNING REQUIREMENTS Computations § 15.820 Chief engineer. (a) There must be an individual holding an MMC or license endorsed as...

  3. 46 CFR 15.820 - Chief engineer.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Chief engineer. 15.820 Section 15.820 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN MANNING REQUIREMENTS Computations § 15.820 Chief engineer. (a) There must be an individual holding an MMC or license endorsed as...

  4. 46 CFR 15.820 - Chief engineer.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Chief engineer. 15.820 Section 15.820 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN MANNING REQUIREMENTS Computations § 15.820 Chief engineer. (a) There must be an individual holding an MMC or license endorsed as...

  5. 46 CFR 15.820 - Chief engineer.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Chief engineer. 15.820 Section 15.820 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN MANNING REQUIREMENTS Computations § 15.820 Chief engineer. (a) There must be an individual holding an MMC or license endorsed as...

  6. 46 CFR 15.820 - Chief engineer.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Chief engineer. 15.820 Section 15.820 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN MANNING REQUIREMENTS Computations § 15.820 Chief engineer. (a) There must be an individual holding an MMC or license endorsed as...

  7. 7 CFR 2.75 - Deputy Chief Financial Officer.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Deputy Chief Financial Officer. 2.75 Section 2.75... AND GENERAL OFFICERS OF THE DEPARTMENT Delegations of Authority by the Chief Financial Officer § 2.75 Deputy Chief Financial Officer. Pursuant to § 2.28, the following delegation of authority is made by the...

  8. 46 CFR 2.20-40 - Chief engineer's reports.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Chief engineer's reports. 2.20-40 Section 2.20-40... INSPECTIONS Reports and Forms § 2.20-40 Chief engineer's reports. (a) Repairs to boilers and pressure vessels. The chief engineer is required to report any repairs to boilers or unfired pressure vessels in...

  9. 46 CFR 2.20-40 - Chief engineer's reports.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Chief engineer's reports. 2.20-40 Section 2.20-40... INSPECTIONS Reports and Forms § 2.20-40 Chief engineer's reports. (a) Repairs to boilers and pressure vessels. The chief engineer is required to report any repairs to boilers or unfired pressure vessels in...

  10. 46 CFR 2.20-40 - Chief engineer's reports.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Chief engineer's reports. 2.20-40 Section 2.20-40... INSPECTIONS Reports and Forms § 2.20-40 Chief engineer's reports. (a) Repairs to boilers and pressure vessels. The chief engineer is required to report any repairs to boilers or unfired pressure vessels in...

  11. 46 CFR 2.20-40 - Chief engineer's reports.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Chief engineer's reports. 2.20-40 Section 2.20-40... INSPECTIONS Reports and Forms § 2.20-40 Chief engineer's reports. (a) Repairs to boilers and pressure vessels. The chief engineer is required to report any repairs to boilers or unfired pressure vessels in...

  12. 46 CFR 2.20-40 - Chief engineer's reports.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Chief engineer's reports. 2.20-40 Section 2.20-40... INSPECTIONS Reports and Forms § 2.20-40 Chief engineer's reports. (a) Repairs to boilers and pressure vessels. The chief engineer is required to report any repairs to boilers or unfired pressure vessels in...

  13. Joint Chiefs of Staff > About > Origin of Joint Concepts

    Science.gov Websites

    Commander in Chief of the Army and Navy; General George C. Marshall, Chief of Staff of the Army; Admiral Ernest J. King, Chief of Naval Operations and Commander in Chief of the U.S. Fleet; and General Henry H JCS: Search Home Media News Photos Videos Publications About The Joint Staff Chairman Vice Chairman

  14. Chief Information Officer > About DoD CIO > Organization > DCIO CS

    Science.gov Websites

    Skip to main content (Press Enter). Toggle navigation Chief Information Officer Search Search Chief Information Officer: Search Search Chief Information Officer: Search Chief Information Officer U.S. Department of Defense Chief Information Officer Home About DoD CIO Bios Organization DCIO C4&IIC DCIO IE

  15. 14 CFR 141.35 - Chief instructor qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... gliders, balloons, or airships, the chief instructor must meet the applicable requirements in paragraphs (b), (c), and (d) of this section; and (6) A chief instructor for a course of training for gliders...

  16. 14 CFR 141.35 - Chief instructor qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... gliders, balloons, or airships, the chief instructor must meet the applicable requirements in paragraphs (b), (c), and (d) of this section; and (6) A chief instructor for a course of training for gliders...

  17. 14 CFR 141.35 - Chief instructor qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... gliders, balloons, or airships, the chief instructor must meet the applicable requirements in paragraphs (b), (c), and (d) of this section; and (6) A chief instructor for a course of training for gliders...

  18. 14 CFR 141.35 - Chief instructor qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... gliders, balloons, or airships, the chief instructor must meet the applicable requirements in paragraphs (b), (c), and (d) of this section; and (6) A chief instructor for a course of training for gliders...

  19. 14 CFR 141.35 - Chief instructor qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... gliders, balloons, or airships, the chief instructor must meet the applicable requirements in paragraphs (b), (c), and (d) of this section; and (6) A chief instructor for a course of training for gliders...

  20. Gen. Joseph F. Dunford, Jr. > Joint Chiefs of Staff > Article View

    Science.gov Websites

    Facebook on Flickr Joint Chiefs Army Chief of Staff Marine Corps Commandant Chief of Naval Operations Air Force Chief of Staff Chief of National Guard Bureau Biographies Directorates Directorates of Management Chiefs of Staff, the nation's highest-ranking military officer, and the principal military advisor to the

  1. 29 CFR 793.9 - “Chief engineer.”

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false âChief engineer.â 793.9 Section 793.9 Labor Regulations... Exemption § 793.9 “Chief engineer.” A chief engineer is an employee who primarily supervises the operation... such engineer may be employed, and in some cases he may be assisted by part-time workers from other...

  2. 29 CFR 793.9 - “Chief engineer.”

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false âChief engineer.â 793.9 Section 793.9 Labor Regulations... Exemption § 793.9 “Chief engineer.” A chief engineer is an employee who primarily supervises the operation... such engineer may be employed, and in some cases he may be assisted by part-time workers from other...

  3. 29 CFR 793.9 - “Chief engineer.”

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false âChief engineer.â 793.9 Section 793.9 Labor Regulations... Exemption § 793.9 “Chief engineer.” A chief engineer is an employee who primarily supervises the operation... such engineer may be employed, and in some cases he may be assisted by part-time workers from other...

  4. 29 CFR 793.9 - “Chief engineer.”

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false âChief engineer.â 793.9 Section 793.9 Labor Regulations... Exemption § 793.9 “Chief engineer.” A chief engineer is an employee who primarily supervises the operation... such engineer may be employed, and in some cases he may be assisted by part-time workers from other...

  5. 29 CFR 793.9 - “Chief engineer.”

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false âChief engineer.â 793.9 Section 793.9 Labor Regulations... Exemption § 793.9 “Chief engineer.” A chief engineer is an employee who primarily supervises the operation... such engineer may be employed, and in some cases he may be assisted by part-time workers from other...

  6. Mister Chief Justice. A Study Guide.

    ERIC Educational Resources Information Center

    Kuehl, John W.

    Intended to accompany the film "Mister Chief Justice," this study guide introduces the life of John Marshall and early U.S. history through a fictional account of a dinner party at the home of the chief justice in March, 1801. The guide presents the historical characters who attended the dinner, including John Marshall, Mary Willis…

  7. 47 CFR 73.1870 - Chief operators.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... to be an employee of the station on duty for whatever number of hours each week the station licensee... Rules Applicable to All Broadcast Stations § 73.1870 Chief operators. (a) The licensee of each AM, FM, TV or Class A TV broadcast station must designate a person to serve as the station's chief operator...

  8. 47 CFR 73.1870 - Chief operators.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... to be an employee of the station on duty for whatever number of hours each week the station licensee... Rules Applicable to All Broadcast Stations § 73.1870 Chief operators. (a) The licensee of each AM, FM, TV or Class A TV broadcast station must designate a person to serve as the station's chief operator...

  9. 47 CFR 73.1870 - Chief operators.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... to be an employee of the station on duty for whatever number of hours each week the station licensee... Rules Applicable to All Broadcast Stations § 73.1870 Chief operators. (a) The licensee of each AM, FM, TV or Class A TV broadcast station must designate a person to serve as the station's chief operator...

  10. 47 CFR 73.1870 - Chief operators.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... to be an employee of the station on duty for whatever number of hours each week the station licensee... Rules Applicable to All Broadcast Stations § 73.1870 Chief operators. (a) The licensee of each AM, FM, TV or Class A TV broadcast station must designate a person to serve as the station's chief operator...

  11. 47 CFR 73.1870 - Chief operators.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... to be an employee of the station on duty for whatever number of hours each week the station licensee... Rules Applicable to All Broadcast Stations § 73.1870 Chief operators. (a) The licensee of each AM, FM, TV or Class A TV broadcast station must designate a person to serve as the station's chief operator...

  12. A CASE OF ACUTE ENDOCARDITIS CAUSED BY MICROCOCCUS ZYMOGENES (NOV. SPEC.), WITH A DESCRIPTION OF THE MICROORGANISM

    PubMed Central

    MacCallum, William G.; Hastings, Thomas W.

    1899-01-01

    From a case of acute endocarditis of the aortic and mitral valves with infarctions m the spleen and kidneys a micrococcus was twice isolated in pure culture from the blood during life and was demonstrated after death both microscopically and in pure culture in large numbers in the valvular vegetations, the infarctions and other parts. No other species of microorganism was found. This micrococcus is very small, occurs mainly in pairs, sometimes in short chains, stains by Gram's method, grows in small, pale, grayish-white colonies on gelatine and agar, at first clouds bouillon, which then becomes clear with a whitish sediment, does not produce gas in glucose media, liquefies gelatine slowly and to some extent also blood serum, and is especially characterized by its behavior in milk, which it acidifies, coagulates and subsequently liquefies. It produces a milk-curdling ferment and also a proteolytic ferment, each of which is separable from the bacterial cells. It remains viable for months in old cultures and is tolerably resistant to the action of heat and antiseptics. The micrococcus is pathogenic for mice and rabbits, causing either abscesses or general infections. Typical acute vegetative endocarditis was experimentally produced by intravenous inoculation of the organism in a rabbit and a dog, and the cocci were demonstrated in pure culture in the vegetations and other parts of these animals after death. Although the micrococcus here described has some points of resemblance to the pneumococcus and Streptococcus pyogenes on the one hand and to the pyogenic staphylococci on the other, it is readily distinguished from each of these species by cultural features which have been described and which are so obvious that the differentiation of these species from our micrococcus need not be discussed in detail. We have searched through the records concerning microorganisms described in association with endocarditis and other diseases, as well as those isolated from water

  13. A CASE OF ACUTE ENDOCARDITIS CAUSED BY MICROCOCCUS ZYMOGENES (NOV. SPEC.), WITH A DESCRIPTION OF THE MICROORGANISM.

    PubMed

    Maccallum, W G; Hastings, T W

    1899-09-01

    From a case of acute endocarditis of the aortic and mitral valves with infarctions m the spleen and kidneys a micrococcus was twice isolated in pure culture from the blood during life and was demonstrated after death both microscopically and in pure culture in large numbers in the valvular vegetations, the infarctions and other parts. No other species of microorganism was found. This micrococcus is very small, occurs mainly in pairs, sometimes in short chains, stains by Gram's method, grows in small, pale, grayish-white colonies on gelatine and agar, at first clouds bouillon, which then becomes clear with a whitish sediment, does not produce gas in glucose media, liquefies gelatine slowly and to some extent also blood serum, and is especially characterized by its behavior in milk, which it acidifies, coagulates and subsequently liquefies. It produces a milk-curdling ferment and also a proteolytic ferment, each of which is separable from the bacterial cells. It remains viable for months in old cultures and is tolerably resistant to the action of heat and antiseptics. The micrococcus is pathogenic for mice and rabbits, causing either abscesses or general infections. Typical acute vegetative endocarditis was experimentally produced by intravenous inoculation of the organism in a rabbit and a dog, and the cocci were demonstrated in pure culture in the vegetations and other parts of these animals after death. Although the micrococcus here described has some points of resemblance to the pneumococcus and Streptococcus pyogenes on the one hand and to the pyogenic staphylococci on the other, it is readily distinguished from each of these species by cultural features which have been described and which are so obvious that the differentiation of these species from our micrococcus need not be discussed in detail. We have searched through the records concerning microorganisms described in association with endocarditis and other diseases, as well as those isolated from water

  14. About the Joint Chiefs of Staff

    Science.gov Websites

    JCS: Search Home Media News Photos Videos Publications About The Joint Staff Chairman Vice Chairman J8 | Force Structure, Resources & Assessment Contact Joint Staff Structure Home : About About the Joint Chiefs of Staff Download the CJCS Historic Guide The Joint Chiefs of Staff consist of the Chairman

  15. 29 CFR 20.10 - Responsibilities of the Chief Financial Officer.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Responsibilities of the Chief Financial Officer. 20.10... to Credit Reporting Agencies § 20.10 Responsibilities of the Chief Financial Officer. The Chief... guidelines and instructions, which he or she may deem appropriate. The Chief Financial Officer shall also...

  16. 29 CFR 20.37 - Responsibilities of the Chief Financial Officer.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Responsibilities of the Chief Financial Officer. 20.37....37 Responsibilities of the Chief Financial Officer. The Chief Financial Officer, or his or her..., which he or she may deem appropriate. The Chief Financial Officer shall also take such administrative...

  17. 29 CFR 20.90 - Responsibilities of the Chief Financial Officer.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Responsibilities of the Chief Financial Officer. 20.90... Responsibilities of the Chief Financial Officer. The Chief Financial Officer, or his or her designee, shall provide... appropriate. The Chief Financial Officer shall also take such administrative steps as may be appropriate to...

  18. 29 CFR 20.62 - Responsibilities of the Chief Financial Officer.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Responsibilities of the Chief Financial Officer. 20.62... Administrative Costs § 20.62 Responsibilities of the Chief Financial Officer. The Chief Financial Officer, or his... instructions, which he or she may deem appropriate. The Chief Financial Officer shall also take such...

  19. 39 CFR 3004.60 - Chief Freedom of Information Act Officer.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Chief Freedom of Information Act Officer. 3004.60... INFORMATION ACT § 3004.60 Chief Freedom of Information Act Officer. The Commission designates the Secretary of the Commission as the Chief FOIA Officer. The Chief FOIA Officer shall be responsible for the...

  20. 39 CFR 3004.60 - Chief Freedom of Information Act Officer.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Chief Freedom of Information Act Officer. 3004.60... INFORMATION ACT § 3004.60 Chief Freedom of Information Act Officer. The Commission designates the Secretary of the Commission as the Chief FOIA Officer. The Chief FOIA Officer shall be responsible for the...

  1. 39 CFR 3004.60 - Chief Freedom of Information Act Officer.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Chief Freedom of Information Act Officer. 3004.60... INFORMATION ACT § 3004.60 Chief Freedom of Information Act Officer. The Commission designates the Secretary of the Commission as the Chief FOIA Officer. The Chief FOIA Officer shall be responsible for the...

  2. 39 CFR 3004.60 - Chief Freedom of Information Act Officer.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Chief Freedom of Information Act Officer. 3004.60... INFORMATION ACT § 3004.60 Chief Freedom of Information Act Officer. The Commission designates the Secretary of the Commission as the Chief FOIA Officer. The Chief FOIA Officer shall be responsible for the...

  3. 46 CFR 11.542 - Endorsement as chief engineer (MODU).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Endorsement as chief engineer (MODU). 11.542 Section 11... REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.542 Endorsement as chief engineer (MODU). To qualify for an endorsement as chief engineer (MODU) an applicant must: (a...

  4. 46 CFR 11.542 - Endorsement as chief engineer (MODU).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Endorsement as chief engineer (MODU). 11.542 Section 11... REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.542 Endorsement as chief engineer (MODU). To qualify for an endorsement as chief engineer (MODU) an applicant must: (a...

  5. 46 CFR 11.542 - Endorsement as chief engineer (MODU).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Endorsement as chief engineer (MODU). 11.542 Section 11... REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.542 Endorsement as chief engineer (MODU). To qualify for an endorsement as chief engineer (MODU) an applicant must: (a...

  6. 46 CFR 11.542 - Endorsement as chief engineer (MODU).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Endorsement as chief engineer (MODU). 11.542 Section 11... REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for National Engineer Officer Endorsements § 11.542 Endorsement as chief engineer (MODU). (a) To qualify for an endorsement as chief engineer (MODU...

  7. 46 CFR 11.542 - Endorsement as chief engineer (MODU).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Endorsement as chief engineer (MODU). 11.542 Section 11... REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.542 Endorsement as chief engineer (MODU). To qualify for an endorsement as chief engineer (MODU) an applicant must: (a...

  8. 28 CFR 0.117 - Office of Chief Immigration Judge.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Office of Chief Immigration Judge. 0.117... Executive Office for Immigration Review § 0.117 Office of Chief Immigration Judge. The Chief Immigration Judge shall provide general supervision to the Immigration Judges in performance of their duties in...

  9. 17 CFR 3.3 - Chief compliance officer.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Chief compliance officer. 3.3 Section 3.3 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION REGISTRATION Registration § 3.3 Chief compliance officer. (a) Designation. Each futures commission merchant, swap dealer...

  10. 17 CFR 3.3 - Chief compliance officer.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 1 2014-04-01 2014-04-01 false Chief compliance officer. 3.3 Section 3.3 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION REGISTRATION Registration § 3.3 Chief compliance officer. (a) Designation. Each futures commission merchant, swap dealer...

  11. 75 FR 15430 - Chief Joseph Hatchery Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-29

    ...: Bonneville Power Administration (BPA), Department of Energy (DOE). ACTION: Notice of availability of Record... proposed action identified in BPA's Chief Joseph Hatchery Program Environmental Impact Statement (DOE/EIS-0384, November 2009). BPA has decided to fund the construction, operation, and maintenance of the Chief...

  12. Bobi A. Garrett - Deputy Laboratory Director and Chief Operating Officer

    Science.gov Websites

    | NREL Bobi A. Garrett - Deputy Laboratory Director and Chief Operating Officer Bobi A. Garrett - Deputy Laboratory Director and Chief Operating Officer A photo of Bobi A. Garrett, Deputy Laboratory Director and Chief Operating Officer In her role as deputy laboratory director/chief operating officer (COO

  13. 47 CFR 54.704 - The Administrator's Chief Executive Officer.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false The Administrator's Chief Executive Officer. 54... Administrator shall nominate by consensus a Chief Executive Officer. The Board of Directors shall submit the... Administrator's Chief Executive Officer. (3) If the Board of Directors does not reach consensus on a nominee or...

  14. 14 CFR § 1212.703 - NASA Chief Information Officer.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false NASA Chief Information Officer. § 1212.703 Section § 1212.703 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS NASA Authority and Responsibilities § 1212.703 NASA Chief Information Officer. (a) The NASA Chief...

  15. 32 CFR 552.37 - Acquisition by Chief of Engineers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 3 2011-07-01 2009-07-01 true Acquisition by Chief of Engineers. 552.37 Section... Interest Therein § 552.37 Acquisition by Chief of Engineers. (a) Statutory authority. The Chief of Engineers, under the direction of the Secretary of the Army, is charged with the acquisition of all real...

  16. 32 CFR 552.37 - Acquisition by Chief of Engineers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 3 2012-07-01 2009-07-01 true Acquisition by Chief of Engineers. 552.37 Section... Interest Therein § 552.37 Acquisition by Chief of Engineers. (a) Statutory authority. The Chief of Engineers, under the direction of the Secretary of the Army, is charged with the acquisition of all real...

  17. 32 CFR 552.37 - Acquisition by Chief of Engineers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 3 2014-07-01 2014-07-01 false Acquisition by Chief of Engineers. 552.37... Interest Therein § 552.37 Acquisition by Chief of Engineers. (a) Statutory authority. The Chief of Engineers, under the direction of the Secretary of the Army, is charged with the acquisition of all real...

  18. 32 CFR 552.37 - Acquisition by Chief of Engineers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 3 2013-07-01 2013-07-01 false Acquisition by Chief of Engineers. 552.37... Interest Therein § 552.37 Acquisition by Chief of Engineers. (a) Statutory authority. The Chief of Engineers, under the direction of the Secretary of the Army, is charged with the acquisition of all real...

  19. 32 CFR 552.37 - Acquisition by Chief of Engineers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Acquisition by Chief of Engineers. 552.37 Section... Interest Therein § 552.37 Acquisition by Chief of Engineers. (a) Statutory authority. The Chief of Engineers, under the direction of the Secretary of the Army, is charged with the acquisition of all real...

  20. The Chief Clinical Informatics Officer (CCIO)

    PubMed Central

    Sengstack, Patricia; Thyvalikakath, Thankam Paul; Poikonen, John; Middleton, Blackford; Payne, Thomas; Lehmann, Christoph U

    2016-01-01

    Summary Introduction The emerging operational role of the “Chief Clinical Informatics Officer” (CCIO) remains heterogeneous with individuals deriving from a variety of clinical settings and backgrounds. The CCIO is defined in title, responsibility, and scope of practice by local organizations. The term encompasses the more commonly used Chief Medical Informatics Officer (CMIO) and Chief Nursing Informatics Officer (CNIO) as well as the rarely used Chief Pharmacy Informatics Officer (CPIO) and Chief Dental Informatics Officer (CDIO). Background The American Medical Informatics Association (AMIA) identified a need to better delineate the knowledge, education, skillsets, and operational scope of the CCIO in an attempt to address the challenges surrounding the professional development and the hiring processes of CCIOs. Discussion An AMIA task force developed knowledge, education, and operational skillset recommendations for CCIOs focusing on the common core aspect and describing individual differences based on Clinical Informatics focus. The task force concluded that while the role of the CCIO currently is diverse, a growing body of Clinical Informatics and increasing certification efforts are resulting in increased homogeneity. The task force advised that 1.) To achieve a predictable and desirable skillset, the CCIO must complete clearly defined and specified Clinical Informatics education and training. 2.) Future education and training must reflect the changing body of knowledge and must be guided by changing day-to-day informatics challenges. Conclusion A better defined and specified education and skillset for all CCIO positions will motivate the CCIO workforce and empower them to perform the job of a 21st century CCIO. Formally educated and trained CCIOs will provide a competitive advantage to their respective enterprise by fully utilizing the power of Informatics science. PMID:27081413

  1. Chief Information Officer > About DoD CIO > Organization > DCIO R&A

    Science.gov Websites

    provide strategy, leadership, and guidance to create a unified information management and technology Skip to main content (Press Enter). Toggle navigation Chief Information Officer Search Search Chief Information Officer: Search Search Chief Information Officer: Search Chief Information Officer U.S. Department

  2. Engineer Equipment Chief.

    ERIC Educational Resources Information Center

    Marine Corps Inst., Washington, DC.

    This student guide, one of a series of correspondence training courses designed to improve the job performance of members of the Marine Corps, deals with the skills needed by engineer equipment chiefs. Addressed in the five individual units of the course are the following topics: construction management (planning, scheduling, and supervision);…

  3. Chief Information Officer > About DoD CIO > Organization > DCIO C4&IIC

    Science.gov Websites

    Skip to main content (Press Enter). Toggle navigation Chief Information Officer Search Search Chief Information Officer: Search Search Chief Information Officer: Search Chief Information Officer U.S. Department of Defense Chief Information Officer Home About DoD CIO Bios Organization DCIO C4&IIC DCIO IE

  4. [Improvement of work of chiefs of therapeutic and diagnostic hospital departments--chief medical specialists of military districts (fleet)].

    PubMed

    Tregubov, V N; Kostiuchenko, A I; Stetsenko, B G

    2009-03-01

    In now-day conditions, on the background of enlargement and complication of tasks', solved by military health service, it's supervised the increase of significance of qualitative and effective administration by collectives of military-medical organizations. An important role belongs to activity of chiefs of treatment-diagnostic units (centers) of military hospitals. These chiefs in the same time are staff or inorganic medical specialists of military regions (NAVYs).

  5. 7 CFR 2.69 - Director, Office of the Chief Scientist.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Research, Education, and Economics § 2.69 Director, Office of the Chief Scientist. (a) Delegations... Secretary for Research, Education, and Economics to the Director, Office of the Chief Scientist. (1) Provide to the Under Secretary (Chief Scientist of the Department) information on topics that can benefit...

  6. 7 CFR 2.69 - Director, Office of the Chief Scientist.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Research, Education, and Economics § 2.69 Director, Office of the Chief Scientist. (a) Delegations... Secretary for Research, Education, and Economics to the Director, Office of the Chief Scientist. (1) Provide to the Under Secretary (Chief Scientist of the Department) information on topics that can benefit...

  7. 49 CFR 1.49 - Delegations to the Chief Information Officer.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Delegations to the Chief Information Officer. 1.49... POWERS AND DUTIES Office of the Secretary Ost Officials § 1.49 Delegations to the Chief Information Officer. The Chief Information Officer is delegated authority to carry out all functions and...

  8. 49 CFR 1.48 - Office of the Chief Information Officer.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Office of the Chief Information Officer. 1.48... POWERS AND DUTIES Office of the Secretary Ost Officials § 1.48 Office of the Chief Information Officer. The Chief Information Officer (CIO) is the principal information technology (IT), cyber security...

  9. 49 CFR 1.48 - Office of the Chief Information Officer.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Office of the Chief Information Officer. 1.48... POWERS AND DUTIES Office of the Secretary Ost Officials § 1.48 Office of the Chief Information Officer. The Chief Information Officer (CIO) is the principal information technology (IT), cyber security...

  10. 49 CFR 1.49 - Delegations to the Chief Information Officer.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Delegations to the Chief Information Officer. 1.49... POWERS AND DUTIES Office of the Secretary Ost Officials § 1.49 Delegations to the Chief Information Officer. The Chief Information Officer is delegated authority to carry out all functions and...

  11. 49 CFR 1.48 - Office of the Chief Information Officer.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Office of the Chief Information Officer. 1.48... POWERS AND DUTIES Office of the Secretary Ost Officials § 1.48 Office of the Chief Information Officer. The Chief Information Officer (CIO) is the principal information technology (IT), cyber security...

  12. 49 CFR 1.49 - Delegations to the Chief Information Officer.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Delegations to the Chief Information Officer. 1.49... POWERS AND DUTIES Office of the Secretary Ost Officials § 1.49 Delegations to the Chief Information Officer. The Chief Information Officer is delegated authority to carry out all functions and...

  13. Chief Information Officers in Service Organizations: A Survey.

    ERIC Educational Resources Information Center

    Brumm, Eugenia E.

    1988-01-01

    Describes a survey of the 50 top ranked Fortune 500 service organizations that was conducted to determine the prevalence of chief information officers, their reporting relationships, and their reporting responsibilities. Differences between chief information officers and management information systems directors are identified, and suggestions for…

  14. NASA Chief Technologist Douglas Terrier Tours Jacobs' Engineering Development Facility

    NASA Image and Video Library

    2017-08-10

    NASA Chief Technologist Douglas Terrier joins Jacobs General Manager Lon Miller during a tour of the company's Engineering Development Facility in Houston. Jacobs provides advanced technologies used aboard the International Space Station and for deep space exploration. From left: NASA’s Johnson Space Center Chief Technologist Chris Culbert, Chief Technologist Douglas Terrier, Jacobs Clear Lake Group Deputy General Manager Joy Kelly and Jacobs Clear Lake Group General Manager Lon Miller. Date: 08-10-2017 Location: B1 & Jacobs Engineering Subject: NASA Acting Chief Technology Officer Douglas Terrier Tours JSC and Jacobs Photographer: David DeHoyos

  15. Joint Chiefs of Staff > Directorates > Directorates of Management

    Science.gov Websites

    establishes information management requirements and manages the corporate Joint Staff decision process to Force Chief of Staff Chief of National Guard Bureau Biographies Directorates Directorates of Management J8 | Force Structure, Resources & Assessment Contact Directorate of Management Home

  16. 28 CFR 301.313 - Chief Operating Officer review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Chief Operating Officer review. 301.313... ACCIDENT COMPENSATION Compensation for Work-Related Physical Impairment or Death § 301.313 Chief Operating Officer review. Any claimant not satisfied with the Committee's reconsidered decision or decision after a...

  17. 49 CFR 800.28 - Delegation to the Chief Financial Officer.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Delegation to the Chief Financial Officer. 800.28... Authority to Staff Members § 800.28 Delegation to the Chief Financial Officer. The Board delegates to the Chief Financial Officer the authority to settle claims for money damages of $2,500 or less against the...

  18. 46 CFR 97.45-1 - Master and chief engineer responsible.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Master and chief engineer responsible. 97.45-1 Section... VESSELS OPERATIONS Carrying of Excess Steam § 97.45-1 Master and chief engineer responsible. It shall be the duty of the master and the chief engineer of any vessel to require that a steam pressure is not...

  19. 46 CFR 97.45-1 - Master and chief engineer responsible.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Master and chief engineer responsible. 97.45-1 Section... VESSELS OPERATIONS Carrying of Excess Steam § 97.45-1 Master and chief engineer responsible. It shall be the duty of the master and the chief engineer of any vessel to require that a steam pressure is not...

  20. 46 CFR 97.45-1 - Master and chief engineer responsible.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Master and chief engineer responsible. 97.45-1 Section... VESSELS OPERATIONS Carrying of Excess Steam § 97.45-1 Master and chief engineer responsible. It shall be the duty of the master and the chief engineer of any vessel to require that a steam pressure is not...

  1. 46 CFR 97.45-1 - Master and chief engineer responsible.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Master and chief engineer responsible. 97.45-1 Section... VESSELS OPERATIONS Carrying of Excess Steam § 97.45-1 Master and chief engineer responsible. It shall be the duty of the master and the chief engineer of any vessel to require that a steam pressure is not...

  2. 46 CFR 97.45-1 - Master and chief engineer responsible.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Master and chief engineer responsible. 97.45-1 Section... VESSELS OPERATIONS Carrying of Excess Steam § 97.45-1 Master and chief engineer responsible. It shall be the duty of the master and the chief engineer of any vessel to require that a steam pressure is not...

  3. Children's Spirit: Leadership Standards and Chief School Executives

    ERIC Educational Resources Information Center

    Boske, Christa

    2009-01-01

    Purpose: The purpose of this study is to increase awareness of the interactions among school leadership standards, cultural competence, and decision-making practices for chief school executives. Design/methodology/approach: To achieve this objective, 1,087 chief school executives, who were members of the American Association of School…

  4. 32 CFR 700.334 - The Chief of Information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) The Chief of Information is the direct representative of the Secretary of the Navy in all public affairs and internal relations matters. The Chief of Information is authorized to implement Navy public affairs and internal relations policies and to coordinate those Navy and Marine Corps activities of mutual...

  5. Hospitalists: a chief nursing officer's perspective.

    PubMed

    Olender, Lynda

    2005-11-01

    The hospitalist "specialty" is sweeping the inpatient setting with numbers of physicians choosing this specialty expected to exceed 20,000 by 2010. Yet, little is known about the involvement of nursing in the design, implementation, and evaluation of a hospitalist initiative. The author suggests the chief nursing officer's pivotal role in proactively encouraging the design and implementation of a hospitalist-nurse manager patient-centered care delivery model. The chief nursing officer can create an environment to foster research designed to identify outcomes from this partnership of hospitalist and clinical (nurse) manager.

  6. Experiential leadership training for pediatric chief residents: impact on individuals and organizations.

    PubMed

    Doughty, Robert A; Williams, Patricia D; Brigham, Timothy P; Seashore, Charles

    2010-06-01

    The past decade has seen a proliferation of leadership training programs for physicians that teach skills outside the graduate medical education curriculum. To determine the perceived value and impact of an experiential leadership training program for pediatric chief residents on the chief residents and on their programs and institutions. The authors conducted a retrospective study. Surveys were sent to chief residents who completed the Chief Resident Training Program (CRTP) between 1988 and 2003 and to their program directors and department chairs asking about the value of the program, its impact on leadership capabilities, as well as the effect of chief resident training on programs and institutions. Ninety-four percent of the chief residents and 94% of program directors and department chairs reported that the CRTP was "very" or "somewhat" relevant, and 92% of the chief residents indicated CRTP had a positive impact on their year as chief resident; and 75% responded it had a positive impact beyond residency. Areas of greatest positive impact included awareness of personality characteristics, ability to manage conflict, giving and receiving feedback, and relationships with others. Fifty-six percent of chief residents reported having held a formal leadership position since chief residency, yet only 28% reported having received additional leadership training. The study demonstrates a perceived positive impact on CRTP participants and their programs and institutions in the short and long term.

  7. Lawyers in Corporate Chief Executive Positions: A Historical Analysis of Careers.

    ERIC Educational Resources Information Center

    Priest, T. B.; Rothman, Robert A.

    1985-01-01

    The backgrounds and careers of lawyer-corporate chief executive officers in each of three historical populations of corporate chief executive officers are examined. Data indicate that the backgrounds of lawyer-chief executives frequently include attendance at prestigious undergraduate educational institutions and law schools and initial positions…

  8. Vice Chief, National Guard Bureau - The National Guard

    Science.gov Websites

    the ARNG Deputy Director of the ARNG Chief of Staff of the ARNG Command Chief Warrant Officer of the Civic Leader's Guide ARNG Vision 2020 Posture Statement Strategic Direction CNGB ARNG Financial Report -7 J-8 Personal Staff Inspector General Judge Advocate General Officer Management Public Affairs

  9. Outcomes Analysis of Chief Cosmetic Clinic Over 13 Years.

    PubMed

    Walker, Nicholas J; Crantford, John C; Rudolph, Megan A; David, Lisa R

    2018-06-01

    Adequate resident training in aesthetic surgery has become increasingly important with rising demand. Chief resident aesthetic clinics allow hands on experience with an appropriate amount of autonomy. The purpose of this study was to compare resident cosmetic clinic outcomes to those reported in the literature. Furthermore, we sought to assess how effective these clinics can be in preparing residents in performing common aesthetic surgery procedures. A retrospective chart review of 326 patients and 714 aesthetic procedures in our chief cosmetic clinic over a 13-year period was performed, and complication and revision rates were recorded. In addition, an electronic survey was sent to 26 prior chief residents regarding their experience and impressions of the chief resident aesthetic clinic. A total of 713 procedures were performed on 326 patients. Patient ages ranged from 5 to 75 years old (mean, 40.8 years old) with a mean follow-up of 76.2 days. On average, there were 56 procedures performed per year. Of the 714 total procedures performed, there were 136 minor procedures and 578 major procedures. Of the 136 minor procedures, there were no complications and there was 1 revision of a cosmetic injection. Of the 578 major procedures, the overall complication rate was 6.1% and the revision rate was 12.8%. Complication and revision rates for each individual surgery were further analyzed and compared with the literature. The complication rates for these procedures fell within the reference ranges reported. In regards to the chief resident survey, there was a 77% response rate. All respondents reported that the chief resident clinic positively affected their residency education and future practice. Ninety percent of respondents felt "very comfortable" performing facelifts, body contouring, and aesthetic breast surgery. No respondents completed a subsequent cosmetic fellowship, and 60% stated that their positive experience in chief clinic contributed to their decision not

  10. 10 CFR 1.39 - Office of the Chief Human Capital Officer.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Office of the Chief Human Capital Officer. 1.39 Section 1... Headquarters Staff Offices § 1.39 Office of the Chief Human Capital Officer. The Office of the Chief Human... effective organization, utilization, and development of the agency's human resources; (b) Provides labor...

  11. 76 FR 67472 - Order of Succession for the Office of the Chief Information Officer

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-01

    ...: Juanita Galbreath, Deputy Chief Information Officer for Cyber Security and Privacy, Office of the Chief...) Deputy Chief Information Officer, for IT Operations; (3) Deputy Chief Information Officer, for Cyber...

  12. Removal of Hepatitis C Virus-Infected Cells by a Zymogenized Bacterial Toxin

    PubMed Central

    Shapira, Assaf; Shapira, Shiran; Gal-Tanamy, Meital; Zemel, Romy; Tur-Kaspa, Ran; Benhar, Itai

    2012-01-01

    Hepatitis C virus (HCV) infection is a major cause of chronic liver disease and has become a global health threat. No HCV vaccine is currently available and treatment with antiviral therapy is associated with adverse side effects. Moreover, there is no preventive therapy for recurrent hepatitis C post liver transplantation. The NS3 serine protease is necessary for HCV replication and represents a prime target for developing anti HCV therapies. Recently we described a therapeutic approach for eradication of HCV infected cells that is based on protein delivery of two NS3 protease-activatable recombinant toxins we named “zymoxins”. These toxins were inactivated by fusion to rationally designed inhibitory peptides via NS3-cleavable linkers. Once delivered to cells where NS3 protease is present, the inhibitory peptide is removed resulting in re-activation of cytotoxic activity. The zymoxins we described suffered from two limitations: they required high levels of protease for activation and had basal activities in the un-activated form that resulted in a narrow potential therapeutic window. Here, we present a solution that overcame the major limitations of the “first generation zymoxins” by converting MazF ribonuclease, the toxic component of the E. coli chromosomal MazEF toxin-antitoxin system, into an NS3-activated zymoxin that is introduced to cells by means of gene delivery. We constructed an expression cassette that encodes for a single polypeptide that incorporates both the toxin and a fragment of its potent natural antidote, MazE, linked via an NS3-cleavable linker. While covalently paired to its inhibitor, the ribonuclease is well tolerated when expressed in naïve, healthy cells. In contrast, activating proteolysis that is induced by even low levels of NS3, results in an eradication of NS3 expressing model cells and HCV infected cells. Zymoxins may thus become a valuable tool in eradicating cells infected by intracellular pathogens that express

  13. Chief Information Officer Leadership: Reflections of Former U.S. Government Chief Information Officers

    ERIC Educational Resources Information Center

    Ma, Katherine C. L.

    2010-01-01

    Since enactment of the Clinger-Cohen Act in 1996, the median tenure of federal chief information officers (CIOs) has been approximately 2 years and high CIO turnover is a problem (U.S. Government Accountability Office [GAO], 2004). Researchers have conducted little research on what leads to effective performance for government CIOs. This…

  14. 18 CFR 154.308 - Representation of chief accounting officer.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Representation of chief accounting officer. 154.308 Section 154.308 Conservation of Power and Water Resources FEDERAL ENERGY... Material To Be Filed With Changes § 154.308 Representation of chief accounting officer. The filing must...

  15. 18 CFR 154.308 - Representation of chief accounting officer.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Representation of chief accounting officer. 154.308 Section 154.308 Conservation of Power and Water Resources FEDERAL ENERGY... Material To Be Filed With Changes § 154.308 Representation of chief accounting officer. The filing must...

  16. 18 CFR 154.308 - Representation of chief accounting officer.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Representation of chief accounting officer. 154.308 Section 154.308 Conservation of Power and Water Resources FEDERAL ENERGY... Material To Be Filed With Changes § 154.308 Representation of chief accounting officer. The filing must...

  17. 18 CFR 154.308 - Representation of chief accounting officer.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Representation of chief accounting officer. 154.308 Section 154.308 Conservation of Power and Water Resources FEDERAL ENERGY... Material To Be Filed With Changes § 154.308 Representation of chief accounting officer. The filing must...

  18. 18 CFR 154.308 - Representation of chief accounting officer.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Representation of chief accounting officer. 154.308 Section 154.308 Conservation of Power and Water Resources FEDERAL ENERGY... Material To Be Filed With Changes § 154.308 Representation of chief accounting officer. The filing must...

  19. 2016 National Profile of Higher Education Chief Business Officers

    ERIC Educational Resources Information Center

    National Association of College and University Business Officers, 2016

    2016-01-01

    The "2016 National Profile of Higher Education Chief Business Officers" is a triennial report that tracks changes in the demographic characteristics, job duties, and plans for career transitions and retirements of business office chief executives at colleges and universities in 2010, 2013, and 2016. The 2016 study also provides a…

  20. 32 CFR 12.3 - Office of the Chief Prosecutor.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Office of the Chief Prosecutor. 12.3 Section 12.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS... the Department of Defense. (3) The Chief Prosecutor shall have authority to subpoena any individual to...

  1. 32 CFR 12.3 - Office of the Chief Prosecutor.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Office of the Chief Prosecutor. 12.3 Section 12.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS... the Department of Defense. (3) The Chief Prosecutor shall have authority to subpoena any individual to...

  2. 32 CFR 12.3 - Office of the Chief Prosecutor.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Office of the Chief Prosecutor. 12.3 Section 12.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS... the Department of Defense. (3) The Chief Prosecutor shall have authority to subpoena any individual to...

  3. 32 CFR 12.3 - Office of the Chief Prosecutor.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Office of the Chief Prosecutor. 12.3 Section 12.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS... the Department of Defense. (3) The Chief Prosecutor shall have authority to subpoena any individual to...

  4. 32 CFR 12.3 - Office of the Chief Prosecutor.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Office of the Chief Prosecutor. 12.3 Section 12.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS... the Department of Defense. (3) The Chief Prosecutor shall have authority to subpoena any individual to...

  5. 32 CFR 644.491 - Coordination with the Chief of Chaplains.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the Related Land) § 644.491 Coordination with the Chief of Chaplains. The DE will submit applications... advertising, the DE will so advise the Chief of Chaplains, reporting steps taken to obtain a purchaser, and...

  6. Curriculum Design and Implementation of the Emergency Medicine Chief Resident Incubator.

    PubMed

    Gisondi, Michael A; Chou, Adaira; Joshi, Nikita; Sheehy, Margaret K; Zaver, Fareen; Chan, Teresa M; Riddell, Jeffrey; Sifford, Derek P; Lin, Michelle

    2018-02-24

    Background Chief residents receive minimal formal training in preparation for their administrative responsibilities. There is a lack of professional development programs specifically designed for chief residents. Objective In 2015, Academic Life in Emergency Medicine designed and implemented an annual, year-long, training program and virtual community of practice for chief residents in emergency medicine (EM). This study describes the curriculum design process and reports measures of learner engagement during the first two cycles of the curriculum. Methods Kern's Six-Step Approach for curriculum development informed key decisions in the design and implementation of the Chief Resident Incubator. The resultant curriculum was created using constructivist social learning theory, with specific objectives that emphasized the needs for a virtual community of practice, longitudinal content delivery, mentorship for participants, and the facilitation of multicenter digital scholarship. The 12-month curriculum included 11 key administrative or professional development domains, delivered using a combination of digital communications platforms. Primary outcomes measures included markers of learner engagement with the online curriculum, recognized as modified Kirkpatrick Level One outcomes for digital learning. Results An average of 206 chief residents annually enrolled in the first two years of the curriculum, with an overall participation by 33% (75/227) of the allopathic EM residency programs in the United States (U.S.). There was a high level of learner engagement, with an average 13,414 messages posted per year. There were also 42 small group teaching sessions held online, which included 39 faculty and 149 chief residents. The monthly e-newsletter had a 50.7% open rate. Digital scholarship totaled 23 online publications in two years, with 67 chief resident co-authors and 21 faculty co-authors. Conclusions The Chief Resident Incubator is a virtual community of practice that

  7. Curriculum Design and Implementation of the Emergency Medicine Chief Resident Incubator

    PubMed Central

    Chou, Adaira; Joshi, Nikita; Sheehy, Margaret K; Zaver, Fareen; Chan, Teresa M; Riddell, Jeffrey; Sifford, Derek P; Lin, Michelle

    2018-01-01

    Background Chief residents receive minimal formal training in preparation for their administrative responsibilities. There is a lack of professional development programs specifically designed for chief residents. Objective In 2015, Academic Life in Emergency Medicine designed and implemented an annual, year-long, training program and virtual community of practice for chief residents in emergency medicine (EM). This study describes the curriculum design process and reports measures of learner engagement during the first two cycles of the curriculum. Methods Kern’s Six-Step Approach for curriculum development informed key decisions in the design and implementation of the Chief Resident Incubator. The resultant curriculum was created using constructivist social learning theory, with specific objectives that emphasized the needs for a virtual community of practice, longitudinal content delivery, mentorship for participants, and the facilitation of multicenter digital scholarship. The 12-month curriculum included 11 key administrative or professional development domains, delivered using a combination of digital communications platforms. Primary outcomes measures included markers of learner engagement with the online curriculum, recognized as modified Kirkpatrick Level One outcomes for digital learning. Results An average of 206 chief residents annually enrolled in the first two years of the curriculum, with an overall participation by 33% (75/227) of the allopathic EM residency programs in the United States (U.S.). There was a high level of learner engagement, with an average 13,414 messages posted per year. There were also 42 small group teaching sessions held online, which included 39 faculty and 149 chief residents. The monthly e-newsletter had a 50.7% open rate. Digital scholarship totaled 23 online publications in two years, with 67 chief resident co-authors and 21 faculty co-authors. Conclusions The Chief Resident Incubator is a virtual community of practice

  8. 75 FR 32418 - Meeting of the Chief of Naval Operations Executive Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-08

    ... DEPARTMENT OF DEFENSE Department of the Navy Meeting of the Chief of Naval Operations Executive Panel AGENCY: Department of the Navy, DoD. ACTION: Notice of closed meeting. SUMMARY: The Chief of Naval... in the Middle East'' Subcommittee to the Chief of Naval Operations. The meeting will consist of...

  9. Ethical dilemmas facing chief nurses in Japan: A Pilot study.

    PubMed

    Ito, Chiharu; Natsume, Mikiko

    2016-06-01

    Chief nurses are most likely to take the lead in discussing and working to resolve ethical dilemmas, creating an ethical culture within their organization that results in effective ethics training. As the first step in this process, there is a need to define the kinds of ethical dilemmas that chief nurses grapple with on a regular basis as a target for future study. Anonymous written questionnaires and semi-structured interviews. All research procedures were approved by the Chubu University Ethics Review Board, the research institution to which the authors belong (authorization no. 250016). Responses from four chief nurses indicated that ethical dilemmas could be categorized as either those related to patient dignity or those related to management (unique to their roles as administrators). It was also learned that chief nurses struggle with the fact that although they consult with their superiors and others, these efforts do not lead to resolution. The expectation is that going forward, chief nurses will play a central role in acting as coordinators with physicians to promote better communication as well as lead group discussions aimed at providing care that respects patient dignity. © The Author(s) 2015.

  10. Select Higher Education Chief Diversity Officers: Roles, Realities, and Reflections

    ERIC Educational Resources Information Center

    Pittard, Lesley-Anne

    2010-01-01

    This naturalistic inquiry sought to obtain the "essence" of select administrative chief diversity officers (CDOs), by exploring their participant profiles, organizational realities, and career reflections. Participants self-identified as their institution's senior most chief executive, were poised executively, and charged to facilitate an…

  11. Enzymatic aspects in ENT cancer-Matrix metalloproteinases

    PubMed Central

    Zamfir Chiru, AA; Popescu, CR; Gheorghe, DC

    2014-01-01

    Abstract The study of ENT cancer allows the implementation of molecular biology methods in diagnosis, predicting the evolution of the disease and suggesting a certain treatment. MMPs are proteolytic enzymes, zinc dependent endopeptidases, secreted by tissues and proinflammatory cells that play a role in the clearance of cell surface receptors. They are expressed as zymogens (inactive forms). Proteolytic enzymes cleave zymogens generating active forms. They are involved in cell proliferation, adhesion, differentiation, migration, angiogenesis, apoptosis and host defense. PMID:25408759

  12. Navy Leadership -- Master Chief Petty Officer of the Navy

    Science.gov Websites

    Communication Specialist Seaman Jackson Woods (Released) 180501-N-SB460-349 The 2017 Navy Sailors of the Year Communication Specialist 2nd Class Andrew N. Skipworth (Released) 180514-N-OM610-221 Vice Chief of Naval . (Released) 180517-N-MD297-0228 Master Chief Petty Officer of the Navy Steven S. Giordano, speaks during the

  13. A novel protein kinase D inhibitor attenuates early events of experimental pancreatitis in isolated rat acini.

    PubMed

    Thrower, Edwin C; Yuan, Jingzhen; Usmani, Ashar; Liu, Yannan; Jones, Courtney; Minervini, Samantha N; Alexandre, Martine; Pandol, Stephen J; Guha, Sushovan

    2011-01-01

    Novel protein kinase C isoforms (PKC δ and ε) mediate early events in acute pancreatitis. Protein kinase D (PKD/PKD1) is a convergent point of PKC δ and ε in the signaling pathways triggered through CCK or cholinergic receptors and has been shown to activate the transcription factor NF-κB in acute pancreatitis. For the present study we hypothesized that a newly developed PKD/PKD1 inhibitor, CRT0066101, would prevent the initial events leading to pancreatitis. We pretreated isolated rat pancreatic acinar cells with CRT0066101 and a commercially available inhibitor Gö6976 (10 μM). This was followed by stimulation for 60 min with high concentrations of cholecystokinin (CCK, 0.1 μM), carbachol (CCh, 1 mM), or bombesin (10 μM) to induce initial events of pancreatitis. PKD/PKD1 phosphorylation and activity were measured as well as zymogen activation, amylase secretion, cell injury and NF-κB activation. CRT0066101 dose dependently inhibited secretagogue-induced PKD/PKD1 activation and autophosphorylation at Ser-916 with an IC(50) ∼3.75-5 μM but had no effect on PKC-dependent phosphorylation of the PKD/PKD1 activation loop (Ser-744/748). Furthermore, CRT0066101 reduced secretagogue-induced zymogen activation and amylase secretion. Gö6976 reduced zymogen activation but not amylase secretion. Neither inhibitor affected basal zymogen activation or secretion. CRT0066101 did not affect secretagogue-induced cell injury or changes in cell morphology, but it reduced NF-κB activation by 75% of maximal for CCK- and CCh-stimulated acinar cells. In conclusion, CRT0066101 is a potent and specific PKD family inhibitor. Furthermore, PKD/PKD1 is a potential mediator of zymogen activation, amylase secretion, and NF-κB activation induced by a range of secretagogues in pancreatic acinar cells.

  14. 8 CFR 1003.9 - Office of the Chief Immigration Judge.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Office of the Chief Immigration Judge. 1003.9 Section 1003.9 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE GENERAL PROVISIONS EXECUTIVE OFFICE FOR IMMIGRATION REVIEW Office of the Chief Immigration Judge...

  15. NASA Chief Technologist Hosts Town Hall

    NASA Image and Video Library

    2010-05-24

    NASA's Chief Technologists, Bobby Braun, hosts a Town Hall meeting to discuss agency-wide technology policy and programs at NASA Headquarters on Tuesday, May 25, 2010, in Washington. Photo Credit: (NASA/Carla Cioffi)

  16. Machiavelli and the Chief Resident.

    ERIC Educational Resources Information Center

    Raviglione, Mario C.

    1990-01-01

    Precepts from Machiavelli's "The Prince" are used in giving advice to chief residents on how to balance their responsibilities in working for the welfare of both the housestaff and the institution. Subject discussions include the difficulties of introducing change, setting good examples, and supervising former colleagues and peers. (GLR)

  17. Chief Information Officers on Campus.

    ERIC Educational Resources Information Center

    Woodsworth, Anne; And Others

    1987-01-01

    Describes changes in management structures on college campuses that have led to the emergence of the position of chief information officer (CIO) to improve information services. The merging of new information technologies with traditional resources is discussed, the responsibilities of CIOs are described, and possible future developments are…

  18. NHS trust chief executives as heroes?

    PubMed

    Learmonth, M

    2001-01-01

    This paper presents a reading of the transcripts of interviews with NHS Trust Chief Executives. Using a poststructuralist understanding of the interviews, it privileges a reading that (ironically) represents these Chief Executives as heroes. Following the classic hero story line, they leave the civilized order of home and journey into a threatening wilderness where they encounter dangerous and magical things but overcome them all because of their masculine characteristics such as rationality, strength and resourcefulness. One way in which these stories can be understood to have significance is that they (misleadingly but powerfully) portray management as obvious and necessary by evocatively drawing on a myth of ancient origin. The piece concludes with some reflections on the ontological implications of the analysis and reflexive comments on the production of truth as a problem.

  19. NASA Chief Technologist Hosts Town Hall

    NASA Image and Video Library

    2010-05-24

    Bobby Braun, NASA's Chief Technologist, answers questions during a Town Hall meeting to discuss agency-wide technology policy and programs at NASA Headquarters on Tuesday, May 25, 2010, in Washington. Photo Credit: (NASA/Carla Cioffi)

  20. The Eighth Stage of Information Management: Information Resources Management (IRM) vs. Knowledge Management (KM), and the Chief Information Officer (CIO) vs. the Chief Knowledge Officer (CKO).

    ERIC Educational Resources Information Center

    Chen, Rui

    1998-01-01

    Describes the characteristics of the transfer point of information management to knowledge management (KM), what information resources management (IRM) does, and compares information and knowledge management and the roles of chief information officer (CIO) and chief knowledge officer (CKO). (PEN)

  1. The integrity of the RRGDL sequence of the proprotein convertase PC1 is critical for its zymogen and C-terminal processing and for its cellular trafficking.

    PubMed Central

    Lusson, J; Benjannet, S; Hamelin, J; Savaria, D; Chrétien, M; Seidah, N G

    1997-01-01

    In order to define the functional importance of the conserved RRGDL motif in the P-domain of the mammalian proprotein convertases(PCs) we generated and cellularly expressed three mutant PC1 vaccinia-virus (VV) recombinants: ARGDL-PC1, RAGDL-PC1 and RRGEL-PC1. Functionally, these mutants caused a decreased level of processing of pro-opiomelanocortin (POMC) into beta-lipotropic pituitary hormone (beta-LPH), especially in the constitutively secreting BSC40 cells. Pulse-chase analyses demonstrated that, in part, this effect was due to both an increased degradation of the mutant PC1s within the endoplasmic reticulum and to a diminished level of zymogen processing in the same compartment. In addition, within cells containing secretory granules such as PC12 and GH4C1 cells, such mutations prevented the C-terminal auto-processing of PC1 into the fully mature 66 kDa form stored in the secretory granules of regulated cells. Since the 66 kDa PC1 is the most active form of the enzyme, it is proposed that the RRGDL sequence is critical for the generation of maximal intracellular PC1 activity. In regulated cells, co-expression of POMC with PC1 or its mutants together with the general PC inhibitor alpha1-antitrypsin Portland (alpha1-PDX), which acts primarily within the constitutive secretory pathway, demonstrated that the latter completely inhibited the formation of beta-LPH by PC1 mutants, whereas it only partially inhibited the ability of wild-type PC1 to process POMC. This suggests that RRGDL mutations prevent PC1 from entering secretory granules and hence the formation of the 66 kDa PC1, and result in the mis-sorting of PC1 mutants towards the constitutive secretory pathway. This conclusion was further supported by immunocytochemical data demonstrating that RRGDL mutants exhibit an intracellular localization pattern different from that of the granule-associated wild-type PC1,but similar to that of the Golgi-localized convertase PC5-B. PMID:9307023

  2. Non-auditory health effects among air force crew chiefs exposed to high level sound.

    PubMed

    Jensen, Anker; Lund, Søren Peter; Lücke, Thorsten Høgh; Clausen, Ole Voldum; Svendsen, Jørgen Torp

    2009-01-01

    The possibility of non-auditory health effects in connection with occupational exposure to high level sound is supposed by some researchers, but is still debated. Crew chiefs on airfields are exposed to high-level aircraft sound when working close to aircraft with running engines. We compared their health status with a similar control group who were not subject to this specific sound exposure. Health records of 42 crew chiefs were compared to health records of 42 aircraft mechanics and 17 former crew chiefs. The specific sound exposure of crew chiefs was assessed. The number of reported disease cases was generally small, but generally slightly higher among mechanics than among crew chiefs. Diseases of the ear were more frequent among crew chiefs (not significant). Former crew chiefs reported fewer diseases of the ear and more airways infections (both significant). The sound exposure during launch was up to 144 dB (peak) and 124 dB (L(eq) ), but for limited time. The study did not reveal a higher disease frequency in general among crew chiefs. However, it did reveal a tendency to ear diseases, possibly due to their exposure to high-level sound.

  3. 39 CFR 3004.60 - Chief Freedom of Information Act Officer.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Chief Freedom of Information Act Officer. 3004.60 Section 3004.60 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL PUBLIC RECORDS AND FREEDOM OF INFORMATION ACT § 3004.60 Chief Freedom of Information Act Officer. The Commission designates the Secretary of...

  4. NASA Chief Technologist on Panel at Massachusetts Institute of Technology

    NASA Image and Video Library

    2018-02-15

    During MIT's "Better MIT Innovation Week 2018," a group of experts discussed innovation as a critical component to and professional accomplishment. From left: Rebecca Chui, founder, RootsStudio; Reinaldo Normand, entrepreneur in residence, MIT; Douglas Terrier, NASA chief technologist; Linda Foster, chief technologist, Lockheed Martin. (Photo: Damian Barabonkov/MIT Technique)

  5. 76 FR 53935 - Delegation Authority for the Office of the Chief Financial Officer

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... Office of the Chief Financial Officer AGENCY: Office of the Secretary, HUD. ACTION: Notice of delegation of authority. SUMMARY: In this notice, the Secretary of HUD, pursuant to the Chief Financial Officers Act of 1990 (CFO Act), which established the position of the Chief Financial Officer within HUD, is...

  6. NASA Chief Technologist Hosts Town Hall

    NASA Image and Video Library

    2010-05-24

    Bobby Braun, right, NASA's Chief Technologist, answers questions during a Town Hall meeting to discuss agency-wide technology policy and programs at NASA Headquarters on Tuesday, May 25, 2010, in Washington. Photo Credit: (NASA/Carla Cioffi)

  7. 32 CFR 705.2 - Chief of Information and the Office of Information (CHINFO).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of the Secretary of the Navy and of the Chief of Naval Operations in all public affairs and internal... Navy, Chief of Naval Operations, and Chief of Information, the NAVINFOs have a primary mission of... ways through these media to inform the public about naval personnel and activities. (iii) Provide...

  8. 32 CFR 705.2 - Chief of Information and the Office of Information (CHINFO).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of the Secretary of the Navy and of the Chief of Naval Operations in all public affairs and internal... Navy, Chief of Naval Operations, and Chief of Information, the NAVINFOs have a primary mission of... ways through these media to inform the public about naval personnel and activities. (iii) Provide...

  9. 32 CFR 705.2 - Chief of Information and the Office of Information (CHINFO).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of the Secretary of the Navy and of the Chief of Naval Operations in all public affairs and internal... Navy, Chief of Naval Operations, and Chief of Information, the NAVINFOs have a primary mission of... ways through these media to inform the public about naval personnel and activities. (iii) Provide...

  10. Joint Chiefs of Staff > Leadership

    Science.gov Websites

    Senior Enlisted Advisor Joint Staff History Joint Staff Inspector General Joint Staff Structure Origin of J8 | Force Structure, Resources & Assessment Contact Joint Staff Structure Joint Staff Organizational Chart Joint Chiefs of Staff Links Home Today in DOD About DOD Top Issues News Photos/Videos

  11. Correlates of Women's Chief Executive Status: Comparisons with Men Chief Executives and Women Top Managers.

    ERIC Educational Resources Information Center

    Tharenou, Phyllis

    1995-01-01

    In Australia, a sample of 50 female and 52 male chief executive officers (CEOs) and 53 top women managers was drawn from a larger survey. Results showed interpersonal and organizational situation factors (such as female management hierarchy, personal encouragement) were more associated with women CEOs' status. Status was less related to…

  12. Chief Knowledge Officers? Perceptions, Pitfalls, & Potential.

    ERIC Educational Resources Information Center

    Corcoran, Mary; Jones, Rebecca

    1997-01-01

    Argues that few librarians possess the needed competencies to fill the role of "chief knowledge officer" or "knowledge executive." Outlines executive competencies required: communications, leadership, experience, financial management, customer focus, entrepreneurial insight, and information technology grounding; examines gaps…

  13. NASA Chief Technologist Hosts Town Hall

    NASA Image and Video Library

    2010-05-24

    Bobby Braun, NASA's Chief Technologist, is seen on a video monitor during a Town Hall meeting to discuss agency-wide technology policy and programs at NASA Headquarters on Tuesday, May 25, 2010, in Washington. Photo Credit: (NASA/Carla Cioffi)

  14. 46 CFR 78.55-1 - Master and chief engineer responsible.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 3 2014-10-01 2014-10-01 false Master and chief engineer responsible. 78.55-1 Section... OPERATIONS Carrying of Excess Steam § 78.55-1 Master and chief engineer responsible. It shall be the duty of the master and the engineer in charge of the boilers of any vessel to require that a steam pressure is...

  15. 46 CFR 196.45-1 - Master and chief engineer responsible.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Master and chief engineer responsible. 196.45-1 Section... VESSELS OPERATIONS Carrying of Excess Steam § 196.45-1 Master and chief engineer responsible. (a) It shall be the duty of the master and the engineer in charge of the boilers of any vessel to require that a...

  16. 46 CFR 78.55-1 - Master and chief engineer responsible.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 3 2011-10-01 2011-10-01 false Master and chief engineer responsible. 78.55-1 Section... OPERATIONS Carrying of Excess Steam § 78.55-1 Master and chief engineer responsible. It shall be the duty of the master and the engineer in charge of the boilers of any vessel to require that a steam pressure is...

  17. 46 CFR 196.45-1 - Master and chief engineer responsible.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Master and chief engineer responsible. 196.45-1 Section... VESSELS OPERATIONS Carrying of Excess Steam § 196.45-1 Master and chief engineer responsible. (a) It shall be the duty of the master and the engineer in charge of the boilers of any vessel to require that a...

  18. 46 CFR 196.45-1 - Master and chief engineer responsible.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Master and chief engineer responsible. 196.45-1 Section... VESSELS OPERATIONS Carrying of Excess Steam § 196.45-1 Master and chief engineer responsible. (a) It shall be the duty of the master and the engineer in charge of the boilers of any vessel to require that a...

  19. 46 CFR 78.55-1 - Master and chief engineer responsible.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 3 2012-10-01 2012-10-01 false Master and chief engineer responsible. 78.55-1 Section... OPERATIONS Carrying of Excess Steam § 78.55-1 Master and chief engineer responsible. It shall be the duty of the master and the engineer in charge of the boilers of any vessel to require that a steam pressure is...

  20. 46 CFR 78.55-1 - Master and chief engineer responsible.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 3 2013-10-01 2013-10-01 false Master and chief engineer responsible. 78.55-1 Section... OPERATIONS Carrying of Excess Steam § 78.55-1 Master and chief engineer responsible. It shall be the duty of the master and the engineer in charge of the boilers of any vessel to require that a steam pressure is...

  1. 46 CFR 196.45-1 - Master and chief engineer responsible.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Master and chief engineer responsible. 196.45-1 Section... VESSELS OPERATIONS Carrying of Excess Steam § 196.45-1 Master and chief engineer responsible. (a) It shall be the duty of the master and the engineer in charge of the boilers of any vessel to require that a...

  2. 46 CFR 196.45-1 - Master and chief engineer responsible.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Master and chief engineer responsible. 196.45-1 Section... VESSELS OPERATIONS Carrying of Excess Steam § 196.45-1 Master and chief engineer responsible. (a) It shall be the duty of the master and the engineer in charge of the boilers of any vessel to require that a...

  3. Classifying free-text triage chief complaints into syndromic categories with natural language processing.

    PubMed

    Chapman, Wendy W; Christensen, Lee M; Wagner, Michael M; Haug, Peter J; Ivanov, Oleg; Dowling, John N; Olszewski, Robert T

    2005-01-01

    Develop and evaluate a natural language processing application for classifying chief complaints into syndromic categories for syndromic surveillance. Much of the input data for artificial intelligence applications in the medical field are free-text patient medical records, including dictated medical reports and triage chief complaints. To be useful for automated systems, the free-text must be translated into encoded form. We implemented a biosurveillance detection system from Pennsylvania to monitor the 2002 Winter Olympic Games. Because input data was in free-text format, we used a natural language processing text classifier to automatically classify free-text triage chief complaints into syndromic categories used by the biosurveillance system. The classifier was trained on 4700 chief complaints from Pennsylvania. We evaluated the ability of the classifier to classify free-text chief complaints into syndromic categories with a test set of 800 chief complaints from Utah. The classifier produced the following areas under the ROC curve: Constitutional = 0.95; Gastrointestinal = 0.97; Hemorrhagic = 0.99; Neurological = 0.96; Rash = 1.0; Respiratory = 0.99; Other = 0.96. Using information stored in the system's semantic model, we extracted from the Respiratory classifications lower respiratory complaints and lower respiratory complaints with fever with a precision of 0.97 and 0.96, respectively. Results suggest that a trainable natural language processing text classifier can accurately extract data from free-text chief complaints for biosurveillance.

  4. The changing role of the health care chief information officer.

    PubMed

    Wood, G M

    2000-09-01

    Information is the lifeblood of the health care organization. In the past, chief information officers were responsible for nothing else but assuring a constant flow of information. Today, they are being asked to do a great deal more. From E-business to E-health strategy, the chief information officer is the focal point of an organization's ability to leverage new technology.

  5. Fight Crime: Invest in Kids Survey of Police Chief Views of Effective Crime-Fighting Strategies.

    ERIC Educational Resources Information Center

    McDevitt, Jack; Baum, Katrina

    This report provides, in tabular and graphic format, the results of a national poll conducted for the Fight Crime: Invest in Kids campaign. The survey sought opinions of 780 police chiefs: all chiefs from cities with populations over 100,000, a sample of 288 chiefs from cities of less than 25,000, and a sample of 292 chiefs from cities of between…

  6. 41 CFR 102-173.40 - Who is my Chief Information Officer (CIO)?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...-INTERNET GOV DOMAIN Registration § 102-173.40 Who is my Chief Information Officer (CIO)? Your Chief... General Services Administration (GSA) recognizes the cabinet level CIOs listed at http://www.cio.gov. For...

  7. 41 CFR 102-173.40 - Who is my Chief Information Officer (CIO)?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...-INTERNET GOV DOMAIN Registration § 102-173.40 Who is my Chief Information Officer (CIO)? Your Chief... General Services Administration (GSA) recognizes the cabinet level CIOs listed at http://www.cio.gov. For...

  8. 41 CFR 102-173.40 - Who is my Chief Information Officer (CIO)?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...-INTERNET GOV DOMAIN Registration § 102-173.40 Who is my Chief Information Officer (CIO)? Your Chief... General Services Administration (GSA) recognizes the cabinet level CIOs listed at http://www.cio.gov. For...

  9. 41 CFR 102-173.40 - Who is my Chief Information Officer (CIO)?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-INTERNET GOV DOMAIN Registration § 102-173.40 Who is my Chief Information Officer (CIO)? Your Chief... General Services Administration (GSA) recognizes the cabinet level CIOs listed at http://www.cio.gov. For...

  10. 41 CFR 102-173.40 - Who is my Chief Information Officer (CIO)?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-INTERNET GOV DOMAIN Registration § 102-173.40 Who is my Chief Information Officer (CIO)? Your Chief... General Services Administration (GSA) recognizes the cabinet level CIOs listed at http://www.cio.gov. For...

  11. CREW CHIEF: A computer graphics simulation of an aircraft maintenance technician

    NASA Technical Reports Server (NTRS)

    Aume, Nilss M.

    1990-01-01

    Approximately 35 percent of the lifetime cost of a military system is spent for maintenance. Excessive repair time is caused by not considering maintenance during design. Problems are usually discovered only after a mock-up has been constructed, when it is too late to make changes. CREW CHIEF will reduce the incidence of such problems by catching design defects in the early design stages. CREW CHIEF is a computer graphic human factors evaluation system interfaced to commercial computer aided design (CAD) systems. It creates a three dimensional man model, either male or female, large or small, with various types of clothing and in several postures. It can perform analyses for physical accessibility, strength capability with tools, visual access, and strength capability for manual materials handling. The designer would produce a drawing on his CAD system and introduce CREW CHIEF in it. CREW CHIEF's analyses would then indicate places where problems could be foreseen and corrected before the design is frozen.

  12. 76 FR 53939 - Order of Succession for the Office of the Chief Financial Officer

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... Office of the Chief Financial Officer AGENCY: Office of the Secretary, HUD. ACTION: Notice of Order of... Chief Financial Officer. This Order of Succession supersedes all prior Orders of Succession for the Office of the Chief Financial Officer. DATES: Effective Date: August 19, 2011. FOR FURTHER INFORMATION...

  13. 32 CFR 700.403 - Statutory authority and responsibility of the Chief of Naval Operations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Chief of Naval Operations. 700.403 Section 700.403 National Defense Department of Defense (Continued... OFFICIAL RECORDS The Chief of Naval Operations § 700.403 Statutory authority and responsibility of the Chief of Naval Operations. (a) Except as otherwise prescribed by law, and subject to the statutory...

  14. 32 CFR 700.403 - Statutory authority and responsibility of the Chief of Naval Operations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Chief of Naval Operations. 700.403 Section 700.403 National Defense Department of Defense (Continued... OFFICIAL RECORDS The Chief of Naval Operations § 700.403 Statutory authority and responsibility of the Chief of Naval Operations. (a) Except as otherwise prescribed by law, and subject to the statutory...

  15. Gastric adenocarcinoma of the fundic gland (chief cell-predominant type): A review of endoscopic and clinicopathological features

    PubMed Central

    Miyazawa, Masaki; Matsuda, Mitsuru; Yano, Masaaki; Hara, Yasumasa; Arihara, Fumitaka; Horita, Yosuke; Matsuda, Koichiro; Sakai, Akito; Noda, Yatsugi

    2016-01-01

    Gastric adenocarcinoma of the fundic gland (chief cell-predominant type, GA-FG-CCP) is a rare variant of well-differentiated adenocarcinoma, and has been proposed to be a novel disease entity. GA-FG-CCP originates from the gastric mucosa of the fundic gland region without chronic gastritis or intestinal metaplasia. The majority of GA-FG-CCPs exhibit either a submucosal tumor-like superficial elevated shape or a flat shape on macroscopic examination. Narrow-band imaging with endoscopic magnification may reveal a regular or an irregular microvascular pattern, depending on the degree of tumor exposure to the mucosal surface. Pathological analysis of GA-FG-CCPs is characterized by a high frequency of submucosal invasion, rare occurrences of lymphatic and venous invasion, and low-grade malignancy. Detection of diffuse positivity for pepsinogen-I by immunohistochemistry is specific for GA-FG-CCP. Careful endoscopic examination and detailed pathological evaluation are essential for early and accurate diagnosis of GA-FG-CCP. Nearly all GA-FG-CCPs are treated by endoscopic resection due to their small tumor size and low risk of recurrence or metastasis. PMID:28082804

  16. You, the CIO: Can Librarians Make the Jump to "Chief Information Officer"?

    ERIC Educational Resources Information Center

    Rowe, Richard R.

    1987-01-01

    Examines the possible role of the chief information officer in universities and corporations, and the ways in which librarians need to restructure their professional role to qualify for the chief information officer function. (CLB)

  17. NASA chief technologist visits Stennis

    NASA Image and Video Library

    2010-08-26

    NASA Chief Technologist Bobby Braun visited John C. Stennis Space Center on Aug. 26. While at Stennis, he spoke to employees and the media about innovation and technology in NASA's future and the important role Stennis will play in space exploration programs. Braun also toured facilities and received briefings on work under way at the nation's premier rocket engine test facility.

  18. Plastic surgery chief resident clinics: the current state of affairs.

    PubMed

    Neaman, Keith C; Hill, Brian C; Ebner, Ben; Ford, Ronald D

    2010-08-01

    One of the goals of plastic surgery residency programs is to provide effective training in aesthetic surgery. Recently, programs have adopted the idea of chief clinics to provide senior residents with the opportunity to perform cosmetic surgery with an increased level of autonomy. The goal of this article is to characterize chief clinics currently in place and their usefulness in providing effective training in plastic surgery under the precepts set forth by the Accreditation Council for Graduate Medical Education. A survey was created focusing on six broad categories: respondent identifier, clinic structure, clinic monetary earnings, patient demographics, procedures, and educational utility. Surveys were distributed to all plastic surgery residency programs targeting current and recently graduated chief residents, and program directors. A total of 123 surveys were returned. Eighty of the 88 plastic surgery residency programs (91 percent) were represented. Of the programs responding, 71.3 percent (57 programs) had a chief resident clinic. Thirty-two of the respondents (43.8 percent) reported that 100 percent of the procedures performed were cosmetic in nature. Programs differed widely on their frequency of occurrence and support staff available. A majority of respondents felt these clinics enhanced resident understanding of the six Accreditation Council for Graduate Medical Education core competencies. A majority of plastic surgery training programs use the chief clinic model to enhance resident education. These clinics vary in makeup and case distribution but serve as an effective way of teaching autonomy, surgical maturity, and the six Accreditation Council for Graduate Medical Education core competencies.

  19. The chief nurse executive role in large healthcare systems.

    PubMed

    Englebright, Jane; Perlin, Jonathan

    2008-01-01

    Community hospitals are most frequently led by nonclinicians. Although some may have employed physician leaders, most often clinical leadership is provided by a chief nurse executive (CNE) or chief nursing officer. Clinical leadership of community hospital and health systems may similarly be provided by a system-level nursing executive or, often, by a council of facility CNEs. The increasingly competitive healthcare environment in which value-based purchasing of healthcare and pay-for-performance programs demand improved clinical performance for financial success has led to reconsideration of whether a council model can provide either the leadership or adequate attention to clinical (and operational) improvement. In turn, community hospitals and health systems look to CNE or chief nursing officer roles at the highest level of the organization as resources that are able to segue between the clinical and operational domains, translating clinical performance demands into operating strategies and tactics. This article explores CNE characteristics required for success in these increasingly responsible and visible roles.

  20. The Education Chief Resident in Medical Student Education: Indicators of Success

    ERIC Educational Resources Information Center

    Roman, Brenda; Khavari, Andrew; Hart, David

    2010-01-01

    Objective: Although residents are actively involved in teaching medical students, some students do not feel that they get adequate teaching from residents. The position of Education Chief Resident in Medical Student Education was developed to enhance the educational experience for the students, cultivate the academic skills of the education chief,…

  1. 32 CFR 643.4 - Responsibilities of the Chief of Engineers (COE).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Responsibilities of the Chief of Engineers (COE... (CONTINUED) REAL PROPERTY REAL ESTATE General § 643.4 Responsibilities of the Chief of Engineers (COE). (a... estate will be delegated, to the extent feasible, to U.S. Army Division and District Engineers (DE). (e...

  2. 32 CFR 643.4 - Responsibilities of the Chief of Engineers (COE).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true Responsibilities of the Chief of Engineers (COE... (CONTINUED) REAL PROPERTY REAL ESTATE General § 643.4 Responsibilities of the Chief of Engineers (COE). (a... estate will be delegated, to the extent feasible, to U.S. Army Division and District Engineers (DE). (e...

  3. 32 CFR 643.4 - Responsibilities of the Chief of Engineers (COE).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false Responsibilities of the Chief of Engineers (COE... (CONTINUED) REAL PROPERTY REAL ESTATE General § 643.4 Responsibilities of the Chief of Engineers (COE). (a... estate will be delegated, to the extent feasible, to U.S. Army Division and District Engineers (DE). (e...

  4. 32 CFR 643.4 - Responsibilities of the Chief of Engineers (COE).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true Responsibilities of the Chief of Engineers (COE... (CONTINUED) REAL PROPERTY REAL ESTATE General § 643.4 Responsibilities of the Chief of Engineers (COE). (a... estate will be delegated, to the extent feasible, to U.S. Army Division and District Engineers (DE). (e...

  5. 32 CFR 643.4 - Responsibilities of the Chief of Engineers (COE).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Responsibilities of the Chief of Engineers (COE... (CONTINUED) REAL PROPERTY REAL ESTATE General § 643.4 Responsibilities of the Chief of Engineers (COE). (a... estate will be delegated, to the extent feasible, to U.S. Army Division and District Engineers (DE). (e...

  6. The Chief Diversity Officer: An Examination of CDO Models and Strategies

    ERIC Educational Resources Information Center

    Stanley, Christine A.

    2014-01-01

    Herein, C. A. Stanley comments on R. A. Leon's "Journal of Diversity in Higher Education" article, "The Chief Diversity Officer: An Examination of CDO Models and Strategies" that focuses on the role of the chief diversity officer (CDO) in higher education. Stanley, in her position as Vice President and Associate Provost…

  7. Developing a Management Information System for the Chief of Supply.

    DTIC Science & Technology

    1985-09-01

    This study examined the information needs of the Chief of Supply in order to facilitate the development of a Management Information System (MIS...information items found to be available within the SBSS program, it was determined feasible to continue the development of this Management Information System . The...results of this study led to two recommendations. The first was to immediately implement a Management Information System for the Chief of

  8. 78 FR 46239 - Designations of Chief Acquisition Officer and Senior Procurement Executive

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-30

    ... Designations of Chief Acquisition Officer and Senior Procurement Executive and Delegation of Procurement... No. FR-5701-D-01] Designations of Chief Acquisition Officer and Senior Procurement Executive AGENCY... Procurement Officer as the Senior Procurement Executive. DATES: Effective Date: July 24, 2013. FOR FURTHER...

  9. 32 CFR 700.404 - Statutory authority and responsibility of the Office of the Chief of Naval Operations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Office of the Chief of Naval Operations. 700.404 Section 700.404 National Defense Department of Defense... REGULATIONS AND OFFICIAL RECORDS The Chief of Naval Operations § 700.404 Statutory authority and responsibility of the Office of the Chief of Naval Operations. (a) The Office of the Chief of Naval Operations...

  10. The Chief Financial Officer and Government Relations.

    ERIC Educational Resources Information Center

    Lasher, William F.; Grigsby, Gwen; Sullivan, Charlotte

    1999-01-01

    Examines the work of the college or university chief financial officer (CFO) in government relations, focusing on the CFO's responsibilities, methods of working with state legislatures, pitfalls in legislative relations, and special problems faced by institutions in capital cities. (Author/MSE)

  11. Chief nursing officer turnover: chief nursing officers and healthcare recruiters tell their stories.

    PubMed

    Havens, Donna Sullivan; Thompson, Pamela A; Jones, Cheryl B

    2008-12-01

    Chief nursing officers (CNOs) develop environments in which quality patient care is delivered and nurses enjoy professional practice. Because of the growing turbulence in this vital role, the American Organization of Nurse Executives conducted a study to examine CNO turnover as described in interviews with CNOs and healthcare recruiters to inform the development of strategies to improve CNO recruitment and retention and ease transition for those who turn over. The authors present the findings from this research and describe American Organization of Nurse Executives' initiatives to address the identified needs.

  12. 75 FR 53959 - Meeting of the Chief of Naval Operations Executive Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-02

    ... DEPARTMENT OF DEFENSE Department of the Navy Meeting of the Chief of Naval Operations Executive Panel AGENCY: Department of the Navy, DoD. ACTION: Notice of open meeting. SUMMARY: The Chief of Naval Operations (CNO) Executive Panel will deliberate on the findings and proposed recommendations of the Navy...

  13. Perception and Use of Information Sources by Chief Executives in Environmental Scanning.

    ERIC Educational Resources Information Center

    Choo, Chun Wei

    1994-01-01

    Reports on a study of the information sources used in environmental scanning by chief executives of the Canadian telecommunications industry that investigated the relationship between perceived source quality and source use and the chief executives' perception and use of the company library and electronic information sources. (Contains 23…

  14. Dual modulation of chloride conductance by nucleotides in pancreatic and parotid zymogen granules.

    PubMed Central

    Thévenod, F; Gasser, K W; Hopfer, U

    1990-01-01

    The regulation of Cl- conductance by cytoplasmic nucleotides was investigated in pancreatic and parotid zymogen granules. Cl- conductance was assayed by measuring the rate of cation-ionophore-induced osmotic lysis of granules suspended in iso-osmotic salt solutions. Both inhibition and stimulation were observed, depending on the type and concentration of nucleotide. Under optimal conditions, the average inhibition measured in different preparations was 1.6-fold, whereas the average stimulation was 4.4-fold. ATP was inhibitory at 1-10 microM but stimulated Cl- conductance above 50 microM. Stimulation by ATP was more pronounced in granules with low endogenous Cl- conductance. The potency of nucleotides in terms of inhibition was ATP greater than adenosine 5'-[gamma-thio]triphosphate (ATP[S]) greater than UTP much greater than or equal to CTP much greater than or equal to GTP much greater than or equal to guanosine 5'-[gamma-thio]triphosphate (GTP[S]) much greater than or equal to ITP. The potency with respect to stimulation had the following order: adenosine 5'-[beta gamma-methylene]triphosphate (App[CH2]p) greater than ATP greater than guanosine 5'-[beta-thio]diphosphate (GDP[S]). Adenosine 5'-[beta gamma-imido]triphosphate (App[NH]p) was also stimulatory, and was more potent than ATP in the parotid granules, but less potent in the pancreatic granules. Aluminium fluoride stimulated Cl- conductance maximally at 15-30 microM-Al3+ and 10-15 mM-F. F was less effective at higher concentrations. Protein phosphorylation by kinases was apparently not involved, since the nucleotide effects (1) could be mimicked by non-hydrolysable analogues of ATP and GTP, (2) showed reversibility, and (3) were not abolished by the protein kinase inhibitors 1-(5-isoquinolinesulphonyl)-2-methylpiperazine (H-7) or staurosporine. The data suggest the presence of at least two binding sites for nucleotides, whereby occupancy of one induces inhibition and occupancy of the other induces stimulation

  15. 46 CFR 11.510 - Service requirements for chief engineer of steam and/or motor vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Service requirements for chief engineer of steam and/or... Officer § 11.510 Service requirements for chief engineer of steam and/or motor vessels. The minimum service required to qualify an applicant for endorsement as chief engineer of steam and/or motor vessels...

  16. NASA Chief Technologist Douglas Terrier Learns How Jacobs Uses 3-D Printing

    NASA Image and Video Library

    2017-08-10

    A Jacobs engineer shows NASA Chief Technologist Douglas Terrier how the company uses 3-D printers to create inexpensive physical models of new electronically designed hardware. Date: 08-10-2017 Location: B1 & Jacobs Engineering Subject: NASA Acting Chief Technology Officer Douglas Terrier Tours JSC and Jacobs Photographer: David DeHoyos

  17. 17 CFR 200.17 - Chief Management Analyst.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Chief Management Analyst. 200.17 Section 200.17 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Organization and Program Management General Organization...

  18. 7 CFR 2.89 - Chief Information Officer.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... continue, modify, or terminate an information technology program or project. (3) Provide advice and other... computer-based systems for message exchange, scheduling, computer conferencing, televideo technologies, and... removal or replacement of information technology project managers, when, in the opinion of the Chief...

  19. 7 CFR 2.89 - Chief Information Officer.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... continue, modify, or terminate an information technology program or project. (3) Provide advice and other... computer-based systems for message exchange, scheduling, computer conferencing, televideo technologies, and... removal or replacement of information technology project managers, when, in the opinion of the Chief...

  20. The chief information officer in Canadian hospitals: fact or fancy?

    PubMed

    Protti, D J; Carmichael, V

    1992-01-01

    Although the title "chief information officer" (CIO) has enjoyed some success in the private sector, it is not yet a common term in Canadian health care. However, with the explosion of information technology, the particular responsibilities of the person overseeing hospital information are significantly different from those using the title "chief financial officer", "chief operating officer" or "associate/assistant executive director". To determine the popularity of the term in Canada, 146 hospitals with more than 200 beds were surveyed. In all, the person handling hospital information had 40 different titles, with 11 appearing more than once. Only two respondents used CIO as a title. It is suggested that a CIO is a bridge between older systems and models, and new technologies and techniques. The future success of CIOs in Canadian health care, however, depends partly on those holding the positions today, and their acceptance that information is both a resource and a strategic opportunity.

  1. How to appoint a new chief nurse, win friends and influence people.

    PubMed

    Butterworth, Tony

    2004-07-01

    OUR CHIEF nurse for England, Sarah Mullally, has announced her intention to leave the NHS and the search is on for her replacement. Speculation on who it will be is rife; this is an opportune moment therefore to reflect on the ideal qualities of the new chief nursing officer (CNO) for England.

  2. 17 CFR 200.30-11 - Delegation of authority to the Chief Accountant.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Chief Accountant. 200.30-11 Section 200.30-11 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... General Organization § 200.30-11 Delegation of authority to the Chief Accountant. Pursuant to the... Accountant of the Commission, to be performed by him or her or under his or her direction by such person or...

  3. 17 CFR 200.30-11 - Delegation of authority to the Chief Accountant.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Chief Accountant. 200.30-11 Section 200.30-11 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... General Organization § 200.30-11 Delegation of authority to the Chief Accountant. Pursuant to the... Accountant of the Commission, to be performed by him or her or under his or her direction by such person or...

  4. 17 CFR 200.30-11 - Delegation of authority to the Chief Accountant.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Chief Accountant. 200.30-11 Section 200.30-11 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... General Organization § 200.30-11 Delegation of authority to the Chief Accountant. Pursuant to the... Accountant of the Commission, to be performed by him or her or under his or her direction by such person or...

  5. 17 CFR 200.30-11 - Delegation of authority to the Chief Accountant.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Chief Accountant. 200.30-11 Section 200.30-11 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... General Organization § 200.30-11 Delegation of authority to the Chief Accountant. Pursuant to the... Accountant of the Commission, to be performed by him or her or under his or her direction by such person or...

  6. 17 CFR 200.17 - Chief Management Analyst.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Organization and Program Management General Organization...) Organizational structures and delegations of authority; (d) Management information systems and concepts; and (e... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Chief Management Analyst. 200...

  7. 7 CFR 2.37 - Chief Information Officer.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... technology program or project. (3) Providing advice and other assistance to the Secretary and other senior... selection of agency Chief Information Officers and agency major information technology system project... recommendations to Agency Heads for the removal or replacement of information technology project managers, when...

  8. Models for Selecting Chief State School Officers. Policy Memo Series, No. 1.

    ERIC Educational Resources Information Center

    Sanchez, Karen L. Van Til; Hall, Gayle C.

    The process of selecting a chief state school officer (CSSO) can be a significant means of allocating policymaking power in state educational governance. This paper examines the role of the chief state school officer and explains how that role is influenced by the selection process. Four selection models are described, along with the advantages…

  9. The Chief Information Officer in Smaller Organizations.

    ERIC Educational Resources Information Center

    Brown, Eric H.; And Others

    1988-01-01

    Describes a survey of small to moderately sized organizations in South Carolina that examined the role of chief information officers. The discussion covers barriers to the establishment of these positions, the involvement of senior management in information resources management, organizational power structures, and the organizational role of…

  10. Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1.

    PubMed

    Bae, Jong-Sup; Yang, Likui; Rezaie, Alireza R

    2010-11-05

    We recently demonstrated that the Gla domain-dependent interaction of protein C with endothelial protein C receptor (EPCR) leads to dissociation of the receptor from caveolin-1 and recruitment of PAR-1 to a protective signaling pathway. Thus, the activation of PAR-1 by either thrombin or PAR-1 agonist peptide elicited a barrier-protective response if endothelial cells were preincubated with protein C. In this study, we examined whether other vitamin K-dependent coagulation protease zymogens can modulate PAR-dependent signaling responses in endothelial cells. We discovered that the activation of both PAR-1 and PAR-2 in endothelial cells pretreated with factor FX (FX)-S195A, but not other procoagulant protease zymogens, also results in initiation of protective intracellular responses. Interestingly, similar to protein C, FX interaction with endothelial cells leads to dissociation of EPCR from caveolin-1 and recruitment of PAR-1 to a protective pathway. Further studies revealed that, FX activated by factor VIIa on tissue factor bearing endothelial cells also initiates protective signaling responses through the activation of PAR-2 independent of EPCR mobilization. All results could be recapitulated by the receptor agonist peptides to both PAR-1 and PAR-2. These results suggest that a cross-talk between EPCR and an unknown FX/FXa receptor, which does not require interaction with the Gla domain of FX, recruits PAR-1 to protective signaling pathways in endothelial cells.

  11. 75 FR 1001 - U.S. Chief Financial Officer Council; Grants Policy Committee (GPC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-07

    ... NATIONAL SCIENCE FOUNDATION U.S. Chief Financial Officer Council; Grants Policy Committee (GPC... committee of the U.S. Chief Financial Officers (CFO) Council. The Office of Management and Budget (OMB... Government. The GPC is charged with improving the management of federal financial assistance government-wide...

  12. Joint Chiefs of Staff > Directorates > J3 | Operations

    Science.gov Websites

    Joint Staff Structure Joint Staff Inspector General Origin of Joint Concepts U.S. Code | Joint Chiefs of J8 | Force Structure, Resources & Assessment Contact J3 Operations Home : Directorates : J3

  13. Chief Business Officers' Functions: Responsibilities and Importance.

    ERIC Educational Resources Information Center

    Calver, Richard A.; Vogler, Daniel E.

    1985-01-01

    Reports on a survey of 177 chief business officers of public community colleges regarding their responsibilities and the importance they assigned to various role functions. Highlights findings concerning the perceived importance of fiscal/financial duties; endowments as a job function; role in shared planning; and personal attention given to…

  14. Current Perspectives on Chief Residents in Psychiatry

    ERIC Educational Resources Information Center

    Warner, Christopher H.; Rachal, James; Breitbach, Jill; Higgins, Michael; Warner, Carolynn; Bobo, William

    2007-01-01

    Objective: The authors examine qualitative data from outgoing chief residents in psychiatry from the 2004-2005 academic year to 1) determine common characteristics between programs, 2) examine the residents' perspectives on their experiences, and 3) determine their common leadership qualities. Method: The authors sent out self-report surveys via…

  15. 75 FR 19627 - Meeting of the Chief of Naval Operations (CNO) Executive Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-15

    ... DEPARTMENT OF DEFENSE Department of the Navy Meeting of the Chief of Naval Operations (CNO) Executive Panel AGENCY: Department of the Navy, DoD. ACTION: Notice of open meeting. SUMMARY: The CNO... interested groups may submit written statements for consideration by the Chief of Naval Operations Executive...

  16. 17 CFR 49.22 - Chief compliance officer.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... that the registered swap data repository provide fair and open access as set forth in § 49.27 of this...) SWAP DATA REPOSITORIES § 49.22 Chief compliance officer. (a) Definition of Board of Directors. For... data repository, or for those swap data repositories whose organizational structure does not include a...

  17. Wanted: Schools Chiefs for Big-Name Districts

    ERIC Educational Resources Information Center

    Zubrzycki, Jaclyn

    2013-01-01

    Districts across the country, including some of the nation's largest, are facing a spate of superintendent vacancies. Schools chiefs or interim superintendents will be leaving this year or next in at least 17 well-known districts, including Baltimore, Maryland; Boston, Massachusetts; Clark County, Nevada; Indianapolis, Indiana; and Wake County,…

  18. Chief Information Officers: New and Continuing Issues.

    ERIC Educational Resources Information Center

    Edutech Report, 1988

    1988-01-01

    Examines the functions of chief information officers on college campuses, and describes three major categories that the functions fall into, depending on the nature of computing within the institution; i.e., information technology as (1) a strategic resource, (2) an aid to operations, and (3) a source of confusion. (CLB)

  19. Quantitative characterization of the protein contents of the exocrine pancreatic acinar cell by soft x-ray microscopy and advanced digital imaging methods

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Loo, Jr., Billy W.

    2000-06-01

    The study of the exocrine pancreatic acinar cell has been central to the development of models of many cellular processes, especially of protein transport and secretion. Traditional methods used to examine this system have provided a wealth of qualitative information from which mechanistic models have been inferred. However they have lacked the ability to make quantitative measurements, particularly of the distribution of protein in the cell, information critical for grounding of models in terms of magnitude and relative significance. This dissertation describes the development and application of new tools that were used to measure the protein content of the majormore » intracellular compartments in the acinar cell, particularly the zymogen granule. Soft x-ray microscopy permits image formation with high resolution and contrast determined by the underlying protein content of tissue rather than staining avidity. A sample preparation method compatible with x-ray microscopy was developed and its properties evaluated. Automatic computerized methods were developed to acquire, calibrate, and analyze large volumes of x-ray microscopic images of exocrine pancreatic tissue sections. Statistics were compiled on the protein density of several organelles, and on the protein density, size, and spatial distribution of tens of thousands of zymogen granules. The results of these measurements, and how they compare to predictions of different models of protein transport, are discussed.« less

  20. Chief Executive Compensation and Benefits Survey 1995.

    ERIC Educational Resources Information Center

    College and Univ. Personnel Association, Washington, DC.

    This report provides data on salaries, benefits, and perquisites commonly included in the total compensation packages available to higher education chief executives, along with data on employment policies and practices. It is based on a survey of 916 institutions representing all segments of higher education. Data are presented in 141 tables under…

  1. The role of the chief ethics officer in a physician's office.

    PubMed

    Guten, Gary N; Kohn, Harvey S; Zoltan, Donald J; Black, Brian B; Coran, David L; Schneider, John A; Pauers, William

    2004-04-01

    The unique role of the chief ethics officer in a sports medicine office is described and guided by the four principles of ethics, as well as the principles and codes of ethics of the American Medical Association, the International Sports Medicine Federation, and the American Academy of Orthopaedic Surgeons. The chief ethics officer should understand and be conversant with these principles and these codes of medical ethics, and transmit this information in order to further patient goals, physician goals, and employee goals.

  2. 33 CFR 211.13 - Approval of the Office of the Chief of Engineers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Chief of Engineers. 211.13 Section 211.13 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION... of the Office of the Chief of Engineers. In any case in which it may be necessary or advisable in the...

  3. Glycoconjugate pattern of membranes in the acinar cell of the rat pancreas.

    PubMed

    Willemer, S; Köhler, H; Naumann, R; Kern, H F; Adler, G

    1990-01-01

    Lectin-binding studies were performed at the ultrastructural level to characterize glycoconjugate patterns on membrane systems in pancreatic acinar cells of the rat. Five lectins reacting with different sugar moieties were applied to ultrathin frozen sections: concanavalin A (ConA): glucose, mannose; wheat-germ agglutinin (WGA): N-acetylglucosamine, sialic acid; Ricinus communis agglutinin I (RCA I): galactose; Ulex europaeus agglutinin I (UEA I): L-fucose; soybean agglutinin (SBA): N-acetylgalactosamine). Binding sites of lectins were visualized either by direct conjugation to colloidal gold or by the use of a three-step procedure involving additional immune reactions. The rough endoplasmic reticulum and the nuclear envelope of acinar cells was selectively labelled for ConA. The membranes of the Golgi apparatus bound all lectins applied with an increasing intensity proceeding from the cis- to the trans-Golgi area for SBA, UEA I and WGA. In contrast RCA I selectively labelled the trans-Golgi cisternae. The membranes of condensing vacuoles and zymogen granules were labelled for all lectins used although the density of the label differed between the lectins. In contrast the content of zymogen granules failed to bind SBA and WGA. Lysosomal bodies (membranes and content) revealed binding sites for all lectins used. The plasma membranes were heavily labelled by all lectins except for SBA which showed only a weak binding to the lateral and the apical plasma membrane. These results are in accordance to current biochemical knowledge of the successive steps in the glycosylation of membrane proteins. It could be demonstrated, that the cryo-section technique is suitable for the fine structural localisation of surface glycoconjugates of plasma membranes and internal membranes in pancreatic acinar cells using plant lectins.

  4. Waiver Given for New York Schools Chief

    ERIC Educational Resources Information Center

    Samuels, Christina A.

    2010-01-01

    The author reports on a promise to name a chief academic officer as second in charge of the New York City schools which paved the way for Cathleen P. Black to succeed Joel I. Klein as the district's next chancellor. The compromise plan, announced amid intensifying debate over her selection by Mayor Michael R. Bloomberg, won a state waiver…

  5. New Expectations Make State Chiefs Hot Commodities

    ERIC Educational Resources Information Center

    Richard, Alan

    2004-01-01

    This article discusses Arkansas' new compensation package for its new education chief. One recent candidate for the state education director's job is said to have had discussions that included a salary of about $240,000, a substantial bonus for staying a certain number of years, and possibly even a professor's chair at a state university upon…

  6. Schools Chief Search off Schedule in Boston

    ERIC Educational Resources Information Center

    Gewertz, Catherine

    2006-01-01

    The closely watched search for a new superintendent in Boston has taken such a rocky turn that the search committee's revised timeline now envisions January as the starting time for the new schools chief. The district's search committee had planned to select a group of finalists who would then go through public interviews before the school…

  7. Occupational Education, Vocational Education, Career Education--The Issues and Alternatives for Chief State School Officers: Dialogues with Chief State School Officers. Report of a National Invitational Conference for Chief State School Officers.

    ERIC Educational Resources Information Center

    Shook, Mollie W., Ed.; King, Sue J., Ed.

    Collected in the document are eight presentations which were made before a national invitational conference of Chief State School officers at Pinehurst, North Carolina, in April, 1974, taken directly from tapes of the conference. In his introduction, "The Quest for Unity and Understanding," John K. Coster enumerates conference goals: (1)…

  8. 75 FR 22754 - Federal Advisory Committee; Chief of Engineers Environmental Advisory Board; Charter Renewal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... recommendations to the Secretary of Defense, through the Secretary of the Army, Assistant Secretary of the Army (Civil Works), and the Chief of Engineers (U.S. Army Corps of Engineers) on matters relating to... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Chief of Engineers...

  9. Office of the Chief Financial Officer Annual Report 2009

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fernandez, Jeffrey

    2009-12-15

    Presented is the 2009 Chief Financial Officer's Annual Report. The data included in this report has been compiled from the Budget Office, the Controller, Procurement and Property Management and the Sponsored Projects Office.

  10. 76 FR 53938 - Order of Succession for the Office of the Chief Procurement Officer

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5561-D-02] Order of Succession for the...: Notice of Order of Succession. SUMMARY: In this notice, the Chief Procurement Officer designates the Order of Succession for the Office of the Chief Procurement Officer. DATES: Effective Date: August 19...

  11. The Temporal Logic of the Tower Chief System

    NASA Technical Reports Server (NTRS)

    Hazelton, Lyman R., Jr.

    1990-01-01

    The purpose is to describe the logic used in the reasoning scheme employed in the Tower Chief system, a runway configuration management system. First, a review of classical logic is given. Defensible logics, truth maintenance, default logic, temporally dependent propositions, and resource allocation and planning are discussed.

  12. Kashlev Named First Deputy Chief, GRCBL | Poster

    Cancer.gov

    By Nancy Parrish, Staff Writer Editor’s note: The text for this article was adapted from an e-mail announcement to the Center for Cancer Research community from Robert Wiltrout, Ph.D., on September 8, 2014. Robert Wiltrout, Ph.D., director, NCI Center for Cancer Research (CCR), recently announced the appointment of Mikhail Kashlev, Ph.D., to deputy chief of the Gene Regulation

  13. The changing role of the hospital chief financial officer.

    PubMed

    Freitag, T R; Freitag, W

    1980-01-01

    Things are changing. That statement is obviously true of things political, economic and scientific. Not surprisingly, therefore, the statement applies to the activities, responsibilities, qualifications and, ultimately, status of the hospital chief financial officer (CFO).

  14. 71. CHIEF PETTY OFFICERS' LOUNGE AFT LOOKING FORWARD PORT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    71. CHIEF PETTY OFFICERS' LOUNGE - AFT LOOKING FORWARD PORT TO STARBOARD SHOWING COFFEE MESS, ICE CREAM COOLER, ICE MACHINE AND SCUTTLEBUTT. - U.S.S. HORNET, Puget Sound Naval Shipyard, Sinclair Inlet, Bremerton, Kitsap County, WA

  15. User’s Guide for Crew Chief: A Computer Graphics Simulation of an Aircraft Maintenance Technician (Version 1 - CD 20)

    DTIC Science & Technology

    1988-05-25

    theoretical approaches used in developing the proqrams. The introduction of the report (Section 1) gives general background of the concepts and... GENERATION 1-5 1.3 WORKPLACE DESIGN 1-6 1.4 THE CREW CHIEF MAINTENANCE ANALYSIS PROGRAMS 1-7 1.5 GETTING STARTED 1-11 2 CREW CHIEF GENERATION FUNCTIONS...OPTIONS 8-1 9 QUICK REFERENCE 9-1 9.1 CREW CHIEF GENERATION FUNCTIONS (@CCGEN) 9-1 9.1.1 CREW CHIEF Initialization Function (CCINIT) 9-1 9.1.2 CREW CHIEF

  16. EDITORIAL: Outgoing Editor-in-Chief Outgoing Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Hauptmann, Peter

    2012-01-01

    I started in 2002 as Editor-in-Chief of a well established journal—MST (Measurement Science and Technology). It was a time when modern means of communication offered new opportunities for the scientific community—for all scientists and engineers whether at universities, in industry or at other institutions—to access better quality information in a shorter time. This development helped us to be more efficient in our daily scientific work and to anticipate new trends faster than before. A flood of information was created by different search engines. A few online journals or journals published in emerging countries with a similar profile to MST appeared on the market. MST had to provide new answers in response to these developments. In 2002 I postulated two requirements to the journal. Firstly, the publisher has to be up to date. My impression over the years has been that IOPP is excellently organized. That has made it easier for the board members and all our reviewers to concentrate on the scientific aspects of our input to the journal. During all my visits to Bristol or my contacts with the IOPP staff I always met very professional and enthusiastic staff members. They have not only supported and encouraged the ideas and initiatives of the Editorial Board members, but they have also worked hard on establishing one of the most effective journal operations in the field of measurement science and technology. Many authors are well aware of this. Thus I am able to declare that the first requirement for a successful journal has been met. Secondly, the scientific level has to be high and the journal should attract readers from all over the world. This task was the responsibility of the Editorial Board members and of myself. Our strategy was on the one hand to ensure continuity in MST but on the other hand to be open to new trends and developments. Examples of these new aspects of the journal are fields like micro- and nanometrology, measurement techniques for

  17. 8 CFR 1003.9 - Office of the Chief Immigration Judge.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... JUSTICE GENERAL PROVISIONS EXECUTIVE OFFICE FOR IMMIGRATION REVIEW Office of the Chief Immigration Judge..., including procedural instructions regarding the implementation of new statutory or regulatory authorities...

  18. 11 CFR 9428.6 - Chief state election official.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 11 Federal Elections 1 2011-01-01 2011-01-01 false Chief state election official. 9428.6 Section 9428.6 Federal Elections ELECTION ASSISTANCE COMMISSION NATIONAL VOTER REGISTRATION ACT (42 U.S.C... constitution or statutory citations, including but not limited to the specific state requirements, if any...

  19. 11 CFR 9428.6 - Chief state election official.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 11 Federal Elections 1 2014-01-01 2014-01-01 false Chief state election official. 9428.6 Section 9428.6 Federal Elections ELECTION ASSISTANCE COMMISSION NATIONAL VOTER REGISTRATION ACT (42 U.S.C... constitution or statutory citations, including but not limited to the specific state requirements, if any...

  20. 11 CFR 9428.6 - Chief state election official.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Chief state election official. 9428.6 Section 9428.6 Federal Elections ELECTION ASSISTANCE COMMISSION NATIONAL VOTER REGISTRATION ACT (42 U.S.C... constitution or statutory citations, including but not limited to the specific state requirements, if any...

  1. Chief Information Officers in Service and Industrial Organizations.

    ERIC Educational Resources Information Center

    Brumm, Eugenia K.

    1990-01-01

    Describes a survey that examined the role of chief information officers (CIOs) in service and industry organizations. The findings discussed include prevalence of CIOs and their level in the organization, scope of authority, control of resources, involvement in corporate strategy, and personal backgrounds. Conclusions about the actual and intended…

  2. 77 FR 61468 - Delegation by the Chief Financial Officer to the Comptroller of Certain Authorities Under the CFO...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    ... DEPARTMENT OF STATE [Delegation of Authority No. 345] Delegation by the Chief Financial Officer to... the Chief Financial Officer Act, 31 U.S.C. 901 et seq., and by the designation from the President... time. Notwithstanding this delegation of authority, the Chief Financial Officer may at any time...

  3. Understanding School System Administration: Studies of the Contemporary Chief Education Officer. Educational Policy Perspective Series.

    ERIC Educational Resources Information Center

    Leithwood, Kenneth, Ed.; Musella, Donald, Ed.

    This volume presents several distinctive but related empirical studies and opinion pieces about chief education officers (CEOs). The collection begins with (1) "Introduction: A Framework for Understanding School System Administration" (Kenneth Leithwood and Donald Musella). Section A, "Chief Education Officers' Practices and…

  4. Chief information officer--try it on for size.

    PubMed

    Buckland, A E

    1988-08-01

    There is a vital executive-level job emerging in progressive health care settings--chief information officer (CIO). This is a position you might wish to measure against your talents and then tailor your career plans accordingly. This article is designed to help you learn more about health information management career options.

  5. Psychiatry chief resident opinions toward basic and clinical neuroscience training and practice.

    PubMed

    Bennett, Jeffrey I; Handa, Kamna; Mahajan, Aman; Deotale, Pravesh

    2014-04-01

    The authors queried attendees to a chief resident conference on whether program education and training in neuroscience or in translating neuroscience research into practice is sufficient and what changes are needed. The authors developed and administered a 26-item voluntary questionnaire to each attendee at the Chief Residents' Leadership Conference at the American Psychiatric Association 2013 annual meeting in San Francisco, CA. Out of 94 attendees, 55 completed and returned questionnaires (58.5%). A majority of respondents stated that their program provided adequate training in neuroscience (61.8%); opportunities for neuroscience research existed for them (78.2%), but that their program did not prepare them for translating future neuroscience research findings into clinical practice (78.9%) or educate them on the NIMH Research Domain Criteria (83.3%). A majority of respondents stated that the ACGME should require a specific neuroscience curriculum (79.6%). Chief residents believe that curricular and cultural change is needed in psychiatry residency neuroscience education.

  6. May 2018 Letters to the Editor-in-Chief.

    PubMed

    2018-05-01

    Letters to the Editor-in-Chief of JOSPT as follows: "Regarding 'Unraveling the Mechanisms of Manual Therapy'" with Authors' Response "The Use of a Broad or Narrow Definition of Injury in Dance Surveillance" with Authors' Response J Orthop Sports Phys Ther 2018;48(5):421-424. doi:10.2519/jospt.2018.0201.

  7. Reclaiming the Educational Role of Chief Admission Officers.

    ERIC Educational Resources Information Center

    McDonough, Patricia; Robertson, Larry

    1995-01-01

    Describes changes that have occurred in high schools, colleges, and the entrepreneurial admission sector. Relates the evolution of the admission officer's job since the early 1960s and the profession's rapid growth. Details the hybrid role of marketer and educator for chief admissions officers, and issues a call for professional standards. (RJM)

  8. Chief Complaint-Based Performance Measures: A New Focus For Acute Care Quality Measurement

    PubMed Central

    Griffey, Richard T; Pines, Jesse M.; Farley, Heather L.; Phelan, Michael P; Beach, Christopher; Schuur, Jeremiah D; Venkatesh, Arjun K.

    2014-01-01

    Performance measures are increasingly important to guide meaningful quality improvement efforts and value-based reimbursement. Populations included in most current hospital performance measures are defined by recorded diagnoses using International Disease Classification (ICD)-9 codes in administrative claims data. While the diagnosis-centric approach allows the assessment of disease-specific quality, it fails to measure one of the primary functions of emergency department (ED) care which involves diagnosing, risk-stratifying, and treating patients’ potentially life-threatening conditions based on symptoms (i.e. chief complaints). In this paper we propose chief complaint-based quality measures as a means to enhance the evaluation of quality and value in emergency care. We discuss the potential benefits of chief-complaint based measures, describe opportunities to mitigate challenges, propose an example measure set, and present several recommendations to advance this paradigm in ED-based performance measurement. PMID:25443989

  9. Alignment of the system's chief nursing officer: staff or direct line structure?

    PubMed

    Kerfoot, Karlene M; Luquire, Rosemary

    2012-01-01

    The role of the system chief nursing officer nationally and internationally has been traditionally structured as a staff model, a direct line model, or a hybrid that includes parts of each model. The choice of structure should be made after a thorough investigation of what outcomes the system wants this position to accomplish, developing the appropriate structure to achieve these outcomes, and then engaging a chief nursing officer with the skills indicated by the type of structure chosen. This article describes these 3 structures and the support infrastructure necessary for each model.

  10. 76 FR 69031 - Order of Succession for the Office of the Chief Human Capital Officer

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5562-D-02] Order of Succession for the...: Notice of order of succession. SUMMARY: In this notice, the Chief Human Capital Officer for the Department of Housing and Urban Development designates the Order of Succession for the Office of the Chief...

  11. History of the Joint Chiefs of Staff. The Joint Chiefs of Staff and National Policy 1955-1956. Volume VI.

    DTIC Science & Technology

    1992-01-01

    allocation of responsibility among the military services for de- veloping and operating the new weapons systems. This turned out to be a con- tentious...the choices made regarding the allocation of resources and the deployments and strategies to be pursued. The Joint Chiefs of Staff developed their...decisions or preparing recommendations on such specific matters as force levels and budget allocations , clearly took his principal guidance from the

  12. 49. SAC Chief of Staff office, second floor, Awing, building ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    49. SAC Chief of Staff office, second floor, A-wing, building 500, looking northwest - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  13. 46. SAC Commander in Chief entry, second floor, Awing, building ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    46. SAC Commander in Chief entry, second floor, A-wing, building 500, looking north - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  14. 47. SAC Commander in Chief office, second floor, Awing, building ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    47. SAC Commander in Chief office, second floor, A-wing, building 500, looking northwest - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  15. 48. SAC Deputy Commander in Chief office, second floor, Awing, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    48. SAC Deputy Commander in Chief office, second floor, A-wing, building 500, looking southeast - Offutt Air Force Base, Strategic Air Command Headquarters & Command Center, Headquarters Building, 901 SAC Boulevard, Bellevue, Sarpy County, NE

  16. New 'PropCo' chief sets out goals.

    PubMed

    Baillie, Jonathan

    2013-02-01

    Plans now well into implementation, to transfer ownership, this April, of the assets and buildings formerly owned by Primary Care Trusts on their abolition to a new limited company, NHS Property Services, have naturally aroused considerable interest across the healthcare estates community. At last October's Healthcare Estates 2012 conference, Simon Holden, who was appointed Chief Executive of the new Government-owned company in August 2012, explained 'how the organisation will work in practice'.

  17. 32 CFR 644.491 - Coordination with the Chief of Chaplains.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Land) § 644.491 Coordination with the Chief of Chaplains. The DE will submit applications for the... DAEN-REM of his selection. Where no applications are obtained as a result of the advertising, the DE...

  18. Using Chief Complaint in Addition to Diagnosis Codes to Identify Falls in the Emergency Department.

    PubMed

    Patterson, Brian W; Smith, Maureen A; Repplinger, Michael D; Pulia, Michael S; Svenson, James E; Kim, Michael K; Shah, Manish N

    2017-09-01

    To compare incidence of falls in an emergency department (ED) cohort using a traditional International Classification of Diseases, Ninth Revision (ICD-9) code-based scheme and an expanded definition that included chief complaint information and to examine the clinical characteristics of visits "missed" in the ICD-9-based scheme. Retrospective electronic record review. Academic medical center ED. Individuals aged 65 and older seen in the ED between January 1, 2013, and September 30, 2015. Two fall definitions were applied (individually and together) to the cohort: an ICD-9-based definition and a chief complaint definition. Admission rates and 30-day mortality (per encounter) were measured for each definition. Twenty-three thousand eight hundred eighty older adult visits occurred during the study period. Using the most-inclusive definition (ICD-9 code or chief complaint indicating a fall), 4,363 visits (18%) were fall related. Of these visits, 3,506 (80%) met the ICD-9 definition for a fall-related visit, and 2,664 (61%) met the chief complaint definition. Of visits meeting the chief complaint definition, 857 (19.6%) were missed when applying the ICD-9 definition alone. Encounters missed using the ICD-9 definition were less likely to lead to an admission (42.9%, 95% confidence interval (CI) = 39.7-46.3%) than those identified (54.4%, 95% CI = 52.7-56.0%). Identifying individuals in the ED who have fallen based on diagnosis codes underestimates the true burden of falls. Individuals missed according to the code-based definition were less likely to have been admitted than those who were captured. These findings call attention to the value of using chief complaint information to identify individuals who have fallen in the ED-for research, clinical care, or policy reasons. © 2017, Copyright the Authors Journal compilation © 2017, The American Geriatrics Society.

  19. CHIEF SCHOOL OFFICERS, RECOMMENDATIONS AND REPORT OF A SURVEY.

    ERIC Educational Resources Information Center

    PERKINS, JAMES A.; AND OTHERS

    A SUBCOMMITTEE OF THE NEW YORK REGENTS ADVISORY COMMITTEE ON EDUCATIONAL LEADERSHIP INVESTIGATED THE LEADERSHIP POSITION OF CHIEF SCHOOL OFFICERS (CSO'S). THE DATA COLLECTION PROCESS WAS CONDUCTED IN TWO PHASES. A QUESTIONNAIRE SURVEY WAS MADE OF 818 CSO'S (SUPERINTENDENTS, SUPERVISING PRINCIPALS, DISTRICT PRINCIPALS, AND SCHOOL PRINCIPALS). DATA…

  20. The Self-Perceived Leadership Styles of Chief State School Officers and Models of Educational Governance

    ERIC Educational Resources Information Center

    Wiggins, Lori A.

    2013-01-01

    This study examined the leadership styles of the chief state school officers of the United States and the District of Columbia. The entire population of 51 chief state school officers was surveyed and a response rate of 60% was obtained. The study examined the relationship between the leadership style, select demographic variables, and the…

  1. History of the Joint Chiefs of Staff. The Joint Chiefs of Staff and National Policy. Volume 8, 1961 - 1964

    DTIC Science & Technology

    2011-01-01

    Focusing on Internal Security and Civic Action 22" Concentrating on Civic Action 227 Case Studies 231 Cuba: Threat and Target 232 16. Middle East...colleagues, and particularly with senior civilians—more so, possibly, than was actually the case . The Chief Executive extended General LeMay’s term until 1...in order to make his program more palatable politically. In any case , his testimony triggered—or perhaps provided the pretext for—another JCS debate

  2. 2013 Occupant Protection Risk Standing Review Panel Status Review Comments to the Human Research Program, Chief Scientist

    NASA Technical Reports Server (NTRS)

    Steinberg, Susan

    2014-01-01

    On December 17, 2013, the OP Risk SRP, participants from the JSC, HQ, and NRESS participated in a WebEx/teleconference. The purpose of the call was to allow the SRP members to: 1. Receive an update by the Human Research Program (HRP) Chief Scientist or Deputy Chief Scientist on the status of NASA's current and future exploration plans and the impact these will have on the HRP. 2. Receive an update on any changes within the HRP since the 2012 SRP meeting. 3. Receive an update by the Element or Project Scientist(s) on progress since the 2012 SRP meeting. 4. Participate in a discussion with the HRP Chief Scientist, Deputy Chief Scientist, and the Element regarding possible topics to be addressed at the next SRP meeting.

  3. Official Website of the Joint Chiefs of Staff

    Science.gov Websites

    Corps photo by Lance Cpl. Haley McMenamin May 22, 2018 - Fitness means more than just passing a test Australia's Chief of Defence Did You Know We're on Instagram? Check out our latest post! Check out our latest Instagram post! #GenDunford and #SecDef Mattis brief reporters on the U.S., French and UK coordinated

  4. Chief Joseph: The Story of an American Indian.

    ERIC Educational Resources Information Center

    Johnson, R. P.

    Written for children in grades 5-9, this biography of the Nez Perce leader, Chief Joseph, describes the conflict between the Nez Perce American Indian tribe and the United States government, known as the Nez Perce War of 1877. Describing the 1,700 mile retreat of those Nez Perce who refused to surrender their lands to white settlers, ranchers, and…

  5. Confronting the Quiet Crisis: How Chief State School Officers Are Advancing Quality Early Childhood Opportunities

    ERIC Educational Resources Information Center

    Council of Chief State School Officers, 2012

    2012-01-01

    In 2009, the Council of Chief State School Officers (CCSSO) adopted a new policy statement on early childhood education. Based on the work of a task force of 13 chiefs, "A Quiet Crisis: The Urgent Need to Build Early Childhood Systems and Quality Programs for Children Birth to Age Five" presents a compelling argument for why public…

  6. Equity Starts Early: How Chiefs Will Build High-Quality Early Education. A Policy Statement of the Council of Chief State School Officers

    ERIC Educational Resources Information Center

    Stark, Deborah Roderick

    2016-01-01

    With the achievement gap beginning to manifest in children as young as nine months, and 90 percent of brain development occurring during the first five years of life, chiefs are committed to expanding and upgrading early childhood programs and strengthening early elementary teaching and learning to provide equal educational opportunities for every…

  7. The General Surgery Chief Resident Operative Experience

    PubMed Central

    Drake, Frederick Thurston; Horvath, Karen D.; Goldin, Adam B.; Gow, Kenneth W.

    2014-01-01

    IMPORTANCE The chief resident (CR) year is a pivotal experience in surgical training. Changes in case volume and diversity may impact the educational quality of this important year. OBJECTIVE To evaluate changes in operative experience for general surgery CRs. DESIGN, SETTING, AND PARTICIPANTS Review of Accreditation Council for Graduate Medical Education case logs from 1989–1990 through 2011–2012 divided into 5 periods. Graduates in period 3 were the last to train with unrestricted work hours; those in period 4 were part of a transition period and trained under both systems; and those in period 5 trained fully under the 80-hour work week. Diversity of cases was assessed based on Accreditation Council for Graduate Medical Education defined categories. MAIN OUTCOMES AND MEASURES Total cases and defined categories were evaluated for changes over time. RESULTS The average total CR case numbers have fallen (271 in period 1 vs 242 in period 5, P < .001). Total CR cases dropped to their lowest following implementation of the 80-hour work week (236 cases), but rebounded in period 5. The percentage of residents’ 5-year operative experience performed as CRs has decreased (30% in period 1 vs 25.6% in period 5, P < .001). Regarding case mix: thoracic, trauma, and vascular cases declined steadily, while alimentary and intra-abdominal operations increased. Recent graduates averaged 80 alimentary and 78 intra-abdominal procedures during their CR years. Compared with period 1, in which these 2 categories represented 47.1% of CR experience, in period 5, they represented 65.2% (P < .001). Endocrine experience has been relatively unchanged. CONCLUSIONS AND RELEVANCE Total CR cases declined especially acutely following implementation of the 80-hour work week but have since rebounded. Chief resident cases contribute less to overall experience, although this proportion stabilized before the 80-hour work week. Case mix has narrowed, with significant increases in alimentary and

  8. The Managerial Roles of Community College Chief Academic Officers.

    ERIC Educational Resources Information Center

    Anderson, Philip Wayne

    This study utilized Mintzberg's taxonomy of managerial roles to examine the roles performed by community college chief academic officers (CAOs). Mintzberg's taxonomy defines managerial roles as a set of behaviors and identifies 10 distinct roles: (1) figurehead; (2) leader; (3) liaison; (4) monitor; (5) disseminator; (6) spokesperson; (7)…

  9. Experiences of Women of Color University Chief Diversity Officers

    ERIC Educational Resources Information Center

    Nixon, Monica L.

    2017-01-01

    Contemporary models of operationalizing diversity on college campuses focus on the integration of diversity goals with the overall educational mission in ways that maximize the benefits of diversity for all. A growing number of institutions have created chief diversity officer (CDO) positions to procedurally and symbolically centralize diversity…

  10. Libraries and the Chief Information Officer: Implications and Trends.

    ERIC Educational Resources Information Center

    Woodsworth, Anne

    1988-01-01

    Describes the roles and responsibilities of Chief Information Officers (CIOs) in research universities and presents five models of the position. Future trends and needs for management of converging information technologies are then discussed with attention to implications for libraries. Qualifications of the CIO and the future outlook of the…

  11. 75 FR 7453 - Notice of Open Meeting of the Chief of Naval Operations (CNO) Executive Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-19

    ... DEPARTMENT OF DEFENSE Department of the Navy Notice of Open Meeting of the Chief of Naval Operations (CNO) Executive Panel AGENCY: Department of the Navy, DoD. ACTION: Notice. SUMMARY: The CNO... interested groups may submit written statements for consideration by the Chief of Naval Operations Executive...

  12. Obstetrics and gynaecology chief resident attitudes toward teaching junior residents under normal working conditions.

    PubMed

    Gil, Karen M; Savitski, Jennifer L; Bazan, Sara; Patterson, Laurene R; Kirven, Melissa

    2009-09-01

    This study aimed to identify factors that chief residents believe impact the teaching of junior residents under normal working conditions and the areas in which they believe education on the role of resident as teacher would be beneficial. Obstetrics and gynaecology (O&G) chief residents were asked to rate the importance of teaching various skills, how often conflict situations arose, and to identify training that would be helpful through a national web-based survey. An e-mail was sent to coordinators of the Residency Review Committee (RRC) O&G residency programmes with a request that they forward the link to their chief residents three times from January through March 2006. Responses were received from 204 postgraduate Year 4 (PGY4) residents (18% of all PGY4 residents) from 133 programmes (54% of all residency programmes) and 33 states. Teaching junior residents how to prioritise patient care and obtain critical information in an emergent situation was considered very to extremely important by 97%. Conflict situations with junior residents were reported to occur between one and five times by 41-58%; an additional 26-28% reported that these situations occurred six or more times. Residents felt it would be helpful to extremely helpful to have training in resolving conflicts that involved patient care (48-59%), as well as in resolving conflict among junior residents, communicating effectively with them and becoming an effective leader (65-78%). The skills that chief residents considered most important to teach junior residents involved direct patient care. Chief residents would like training in how to resolve conflict with, and among, junior residents, and in how to become an effective leader.

  13. 41 CFR 102-173.85 - How long will my application be held, pending approval by the Chief Information Officer (CIO)?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... application be held, pending approval by the Chief Information Officer (CIO)? 102-173.85 Section 102-173.85... long will my application be held, pending approval by the Chief Information Officer (CIO)? Registrations will be held in reserve status for sixty (60) days pending Chief Information Officer (CIO...

  14. 41 CFR 102-173.85 - How long will my application be held, pending approval by the Chief Information Officer (CIO)?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... application be held, pending approval by the Chief Information Officer (CIO)? 102-173.85 Section 102-173.85... long will my application be held, pending approval by the Chief Information Officer (CIO)? Registrations will be held in reserve status for sixty (60) days pending Chief Information Officer (CIO...

  15. 41 CFR 102-173.85 - How long will my application be held, pending approval by the Chief Information Officer (CIO)?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... application be held, pending approval by the Chief Information Officer (CIO)? 102-173.85 Section 102-173.85... long will my application be held, pending approval by the Chief Information Officer (CIO)? Registrations will be held in reserve status for sixty (60) days pending Chief Information Officer (CIO...

  16. 41 CFR 102-173.85 - How long will my application be held, pending approval by the Chief Information Officer (CIO)?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... application be held, pending approval by the Chief Information Officer (CIO)? 102-173.85 Section 102-173.85... long will my application be held, pending approval by the Chief Information Officer (CIO)? Registrations will be held in reserve status for sixty (60) days pending Chief Information Officer (CIO...

  17. 33 CFR 211.3 - Function of Chief of Engineers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Function of Chief of Engineers. 211.3 Section 211.3 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS...

  18. 33 CFR 211.3 - Function of Chief of Engineers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Function of Chief of Engineers. 211.3 Section 211.3 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS...

  19. 33 CFR 211.3 - Function of Chief of Engineers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Function of Chief of Engineers. 211.3 Section 211.3 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS...

  20. 33 CFR 211.3 - Function of Chief of Engineers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Function of Chief of Engineers. 211.3 Section 211.3 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS...

  1. NASA Acting Chief Technologist Douglas Terrier Tours London’s Science Museum

    NASA Image and Video Library

    2017-09-28

    NASA Acting Chief Technologist Douglas Terrier (right) tours London’s Science Museum with Dr. David Rooney, Keeper of Technologies and Engineer and Doug Millard, Deputy Keeper of Technologies and Engineering.

  2. 46 CFR 78.55-1 - Master and chief engineer responsible.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OPERATIONS Carrying of Excess Steam § 78.55-1 Master and chief engineer responsible. It shall be the duty of the master and the engineer in charge of the boilers of any vessel to require that a steam pressure is...

  3. The Chief Student Affairs Officer: Leader, Manager, Mediator, Educator.

    ERIC Educational Resources Information Center

    Sandeen, Arthur

    This book examines the leadership role of higher education chief student affairs officers (CSAO). Organized in three parts, Part One consists of four chapters that survey the CSAO's responsibilities as a campus leader. The first chapter describes the various roles and functions of the position and discusses its origins and evolution. Chapter Two…

  4. Chief of Naval Air Training Resource Planning System (RPS).

    ERIC Educational Resources Information Center

    Hodak, Gary W.; And Others

    The Resource Planning System (RPS) provides the Chief of Naval Air Training (CNATRA) with the capability to determine the resources required to produce a specified number of Naval Aviators and Naval Flight Officers (NAs/NFOs) quickly and efficiently. The training of NAs and NFOs is extremely time consuming and complex. It requires extensive…

  5. Chief Diversity Officers and the Wonderful World of Academe

    ERIC Educational Resources Information Center

    Harvey, William B.

    2014-01-01

    The chief diversity officer (CDO) position is new in the realm of higher education administration. Charged with helping their institutions become more diverse and inclusive, the people who occupy these positions face a variety of challenges as they attempt to modify change-resistant institutional cultures. Still, the emergence of the CDO position…

  6. An interview with the Chief Dental Officer. Interview by Kenneth A. Eaton.

    PubMed

    Bedi, Raman

    2004-10-01

    Some months ago, I mentioned to Professor Raman Bedi, the Chief Dental Officer (CDO) for England, that Primary DENTAL CARE would be celebrating its tenth anniversary in October 2004. He kindly agreed to a special interview during which he would outline his vision for education, research and opportunities for career development in primary dental care in the future. The timing proved to be perfect as earlier on the day of the interview (16th July 2004), the Secretary of State for Health, John Reid, announced the Government's plans for NHS dentistry and NHS Dentistry: Delivering Change. Report from the Chief Dental Officer (England) 2004 was published.

  7. Distribution and relative abundance of fishes in littoral areas of Chief Joseph Reservoir, Columbia River

    USGS Publications Warehouse

    Gadomski, Dena M.; Venditti, David A.; Robinson, T. Craig; Beeman, John W.; Maule, Alec G.

    2004-01-01

    We surveyed fish assemblages in littoral areas of Chief Joseph Reservoir of the upper Columbia River to aid in understanding this ecosystem. Fish distributions and abundances were examined during April-July 1999 in relation to environmental conditions in the reservoir. We also compared the fish assemblages in Chief Joseph reservoir in 1999 to a past study conducted during 1974-1975, and to assemblages in other areas of the Columbia River. During 67 hr of electrofishing and 78 beach seine hauls in Chief Joseph Reservoir, 7460 fishes representing 8 families were collected. The majority of the catch was native – northern pikeminnow; redside shiners; longnose, bridgelip, and largescale suckers; and sculpins. The most abundant introduced species was walleye, and one species, rainbow trout, was mostly of net-pen origin. Larger sizes of suckers and northern pikeminnow were most abundant in the upper reservoir, likely due to upstream spawning migrations. The lower reservoir contained greater abundances of smaller fishes, and this area had lower flows, smaller substrates, and more complex shorelines that offered these fishes refugia. Only adult suckers displayed significant differences in abundances related to substrate. The relative abundances of species appeared to have changed since the 1970s, when the dominant fishes were northern pikeminnow, peamouth, largescale suckers, and walleye. Fish assemblage differences between Chief Joseph Reservoir and lower Columbia River reservoirs were also evident due to the morphology of the reservoir, its more northerly location, and the lack of fish passage facilities at Chief Joseph Dam. Our study is one of the few descriptions of fishes in the upper Columbia Rivers.

  8. NASA Chief Technologist Speaks at Massachusetts Institute of Technology

    NASA Image and Video Library

    2018-02-15

    NASA Chief Technologist Douglas Terrier joined students, faculty and experts in Boston as part of MIT's "Better MIT Innovation Week 2018," a week-long program promoting leadership, entrepreneurship and action for a better future. During the February event, Terrier spoke about a culture of innovation at America's Space Program. (Photo: Damian Barabonkov/MIT Technique)

  9. The Role of the Chief Student Affairs Officer in Promoting the Jesuit Mission of the University

    ERIC Educational Resources Information Center

    Reiter, Lisa Rose

    2012-01-01

    "The Role of the Chief Student Affairs Officer in Promoting the Jesuit Mission of the University" is a qualitative comparative case study of three lay (non-cleric, non-Jesuit) chief student affairs officers employed in three U.S. Jesuit higher educational institutions. As the number of Jesuits decreases, a significant question is how the…

  10. Deficiency of Sbds in the mouse pancreas leads to features of Shwachman-Diamond syndrome, with loss of zymogen granules.

    PubMed

    Tourlakis, Marina E; Zhong, Jian; Gandhi, Rikesh; Zhang, Siyi; Chen, Lingling; Durie, Peter R; Rommens, Johanna M

    2012-08-01

    Shwachman-Diamond syndrome (SDS) is the second leading cause of hereditary exocrine pancreatic dysfunction. More than 90% of patients with SDS have biallelic loss-of-function mutations in the Shwachman-Bodian Diamond syndrome (SBDS) gene, which encodes a factor involved in ribosome function. We investigated whether mutations in Sbds lead to similar pancreatic defects in mice. Pancreas-specific knock-out mice were generated using a floxed Sbds allele and bred with mice carrying a null or disease-associated missense Sbds allele. Cre recombinase, regulated by the pancreatic transcription factor 1a promoter, was used to disrupt Sbds specifically in the pancreas. Models were assessed for pancreatic dysfunction and growth impairment. Disruption of Sbds in the mouse pancreas was sufficient to recapitulate SDS phenotypes. Pancreata of mice with Sbds mutations had decreased mass, fat infiltration, but general preservation of ductal and endocrine compartments. Pancreatic extracts from mutant mice had defects in formation of the 80S ribosomal complex. The exocrine compartment of mutant mice was hypoplastic and individual acini produced few zymogen granules. The null Sbds allele resulted in an earlier onset of phenotypes as well as endocrine impairment. Mutant mice had reduced serum levels of digestive enzymes and overall growth impairment. We developed a mouse model of SDS with pancreatic phenotypes similar to those of the human disease. This model could be used to investigate organ-specific consequences of Sbds-associated ribosomopathy. Sbds genotypes correlated with phenotypes. Defects developed specifically in the pancreata of mice, reducing growth of mice and production of digestive enzymes. SBDS therefore appears to be required for normal pancreatic development and function. Copyright © 2012 AGA Institute. Published by Elsevier Inc. All rights reserved.

  11. GRANITE CHIEF WILDERNESS STUDY AREA, CALIFORNIA.

    USGS Publications Warehouse

    Harwood, David S.; Federspiel, Francis E.

    1984-01-01

    The Granite Chief Wilderness study area encompasses 57 sq mi near the crest of the Sierra Nevada 6 mi west of Tahoe City, California. Geologic, geochemical, and mines and prospect studies were carried out to assess the mineral-resource potential of the area. On the basis of the mineral-resource survey, it is concluded that the area has little promise for the occurrence of precious or base metals, oil, gas, coal, or geothermal resources. Sand, gravel, and glacial till suitable for construction materials occur in the area, but inaccessability and remoteness from available markets preclude their being shown on the map as a potential resource.

  12. 14 CFR 385.21 - Authority of the Chief, Accounting Division, Office of Budget and Policy, Federal Transit...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Authority of the Chief, Accounting Division... ASSIGNMENTS AND REVIEW OF ACTION UNDER ASSIGNMENTS Assignment of Functions to Staff Members § 385.21 Authority of the Chief, Accounting Division, Office of Budget and Policy, Federal Transit Administration. The...

  13. The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

    PubMed Central

    2016-01-01

    Over the past decade, numerous advances have been made in the role and regulation of inflammasomes during pathogenic and sterile insults. An inflammasome complex comprises a sensor, an adaptor, and a zymogen procaspase-1. The functional output of inflammasome activation includes secretion of cytokines, IL-1β and IL-18, and induction of an inflammatory form of cell death called pyroptosis. Recent studies have highlighted the intersection of this inflammatory response with fundamental cellular processes. Novel modulators and functions of inflammasome activation conventionally associated with the maintenance of homeostatic biological functions have been uncovered. In this review, we discuss the biological processes involved in the activation and regulation of the inflammasome. PMID:27325789

  14. 46 CFR 11.518 - Service requirements for chief engineer (limited oceans) of steam and/or motor vessels.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Service requirements for chief engineer (limited oceans... Requirements for Engineer Officer § 11.518 Service requirements for chief engineer (limited oceans) of steam... engineer (limited oceans) of steam and/or motor vessels is five years total service in the engineroom of...

  15. 46 CFR 11.518 - Service requirements for chief engineer (limited oceans) of steam and/or motor vessels.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Service requirements for chief engineer (limited oceans... Requirements for Engineer Officer § 11.518 Service requirements for chief engineer (limited oceans) of steam... engineer (limited oceans) of steam and/or motor vessels is five years total service in the engineroom of...

  16. 46 CFR 11.518 - Service requirements for chief engineer (limited oceans) of steam and/or motor vessels.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Service requirements for chief engineer (limited oceans... Requirements for Engineer Officer § 11.518 Service requirements for chief engineer (limited oceans) of steam... engineer (limited oceans) of steam and/or motor vessels is five years total service in the engineroom of...

  17. 32 CFR 13.3 - Office of the Chief Defense Counsel.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 13.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY... States armed force and shall be designated by the General Counsel of the Department of Defense. (2) The...) of the Department of Defense. (3) The Chief Defense Counsel shall supervise all defense activities...

  18. 32 CFR 13.3 - Office of the Chief Defense Counsel.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Section 13.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY... States armed force and shall be designated by the General Counsel of the Department of Defense. (2) The...) of the Department of Defense. (3) The Chief Defense Counsel shall supervise all defense activities...

  19. 32 CFR 13.3 - Office of the Chief Defense Counsel.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section 13.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY... States armed force and shall be designated by the General Counsel of the Department of Defense. (2) The...) of the Department of Defense. (3) The Chief Defense Counsel shall supervise all defense activities...

  20. 10 CFR 1.31 - Office of the Chief Financial Officer.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... management policy including accounting principles and standards for the agency and provides policy guidance... accounting and financial management system, including an accounting system, and financial reporting and... 10 Energy 1 2010-01-01 2010-01-01 false Office of the Chief Financial Officer. 1.31 Section 1.31...

  1. 28 CFR 0.118 - Office of Chief Administrative Hearing Officer.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Officer. 0.118 Section 0.118 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Executive Office for Immigration Review § 0.118 Office of Chief Administrative Hearing... Law Judges in performance of their duties in accordance with 8 U.S.C. 1324 A and B. ...

  2. 32 CFR 13.3 - Office of the Chief Defense Counsel.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 13.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY... States armed force and shall be designated by the General Counsel of the Department of Defense. (2) The...) of the Department of Defense. (3) The Chief Defense Counsel shall supervise all defense activities...

  3. 32 CFR 13.3 - Office of the Chief Defense Counsel.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 13.3 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY... States armed force and shall be designated by the General Counsel of the Department of Defense. (2) The...) of the Department of Defense. (3) The Chief Defense Counsel shall supervise all defense activities...

  4. New Concepts for the Administrative Training of Psychiatric Chief Residents

    ERIC Educational Resources Information Center

    Griffith, Ezra; And Others

    1978-01-01

    In 1976 a new organizational structure was established in the Lincoln Psychiatric Residency Program of the Albert Einstein College of Medicine in which the chief resident was given responsibility for the residents in all years of training. Problems and benefits of this broad area of control are addressed. (LBH)

  5. HRP Chief Scientist's Office: Conducting Research to Enable Deep Space Exploration

    NASA Technical Reports Server (NTRS)

    Charles, J. B.; Fogarty, J.; Vega, L.; Cromwell, R. L.; Haven, C. P.; McFather, J. C.; Savelev, I.

    2017-01-01

    The HRP Chief Scientist's Office sets the scientific agenda for the Human Research Program. As NASA plans for deep space exploration, HRP is conducting research to ensure the health of astronauts, and optimize human performance during extended duration missions. To accomplish this research, HRP solicits for proposals within the U.S., collaborates with agencies both domestically and abroad, and makes optimal use of ISS resources in support of human research. This session will expand on these topics and provide an opportunity for questions and discussion with the HRP Chief Scientist. Presentations in this session will include: NRA solicitations - process improvements and focus for future solicitations, Multilateral Human Research Panel for Exploration - future directions (MHRPE 2.0), Extramural liaisons - National Science Foundation (NSF) and Department of Defense (DOD), Standardized Measures for spaceflight, Ground-based Analogs - international collaborations, and International data sharing.

  6. EDITORIAL: New Editor-in-Chief for Nanotechnology New Editor-in-Chief for Nanotechnology

    NASA Astrophysics Data System (ADS)

    Couzin, Nina

    2009-01-01

    Nanotechnology is proud to announce the appointment of Professor Mark Reed, Yale University, as the new Editor-in-Chief from January 2009. Mark Reed holds the Harold Hodgkinson Chair of Engineering and Applied Science at Yale University. He has made significant contributions in the areas of quantum dots, electronic transport in nanoscale and mesoscopic systems, artificially structured materials and devices, and molecular electronics. Professor Reed has been associated with the journal as an Editorial Board member for a number of years and we are delighted that he has agreed to take on the scientific leadership of the journal in its 20th year. We also take the opportunity to thank Professor Mark Welland, Cambridge University, for his work as Editor-in-Chief since 2001, and for presiding over the re-launch and remarkable growth of the journal since then. Nanotechnology is unique in that it was the first peer-reviewed journal in the area of nanoscience, the first issue appearing in 1990. Since then it has established a distinguished publication record and has become a leading journal covering all aspects of nanoscale science and technology, as well as specializing in in-depth, comprehensive articles not seen in letter format journals. Published weekly and featuring subject sections, the journal is truly multidisciplinary in nature and is an excellent medium to quickly deliver your research results to readers worldwide. Nanotechnology is proud to be offering some of the fastest publication times around (less than three months on average from receipt to online publication). We offer free online access to all published papers for 30 days, ensuring that anyone with access to the internet will be able to read your paper. We were also the first journal to give our authors the opportunity to communicate their research to a wider audience through nanotechweb.org and other IOP websites. See the journal's homepage at www.iop.org/Journals/nano for more details. We are looking

  7. 2013 Pharmacology Risk SRP Status Review Comments to Chief Scientist. The Risk of Clinically Relevant Unpredicted Effects of Medication

    NASA Technical Reports Server (NTRS)

    2014-01-01

    On December 5, 2013, the Pharmacology Risk SRP, participants from the JSC, HQ, the NSBRI, and NRESS participated in a WebEx/teleconference. The purpose of the call (as stated in the Statement of Task) was to allow the SRP members to: 1. Receive an update by the HRP Chief Scientist or Deputy Chief Scientist on the status of NASA's current and future exploration plans and the impact these will have on the HRP. 2. Receive an update on any changes within the HRP since the 2012 SRP meeting. 3. Receive an update by the Element or Project Scientist(s) on progress since the 2012 SRP meeting. 4. Participate in a discussion with the HRP Chief Scientist, Deputy Chief Scientist, and the Element regarding possible topics to be addressed at the next SRP meeting.

  8. 29 CFR 793.11 - Combination announcer, news editor and chief engineer.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... editor and chief engineer. The 13(b)(9) exemption, as was made clear during the debate on the amendment... television stations. It is known at the time of such debate that these stations employ only a small number of...

  9. 29 CFR 793.11 - Combination announcer, news editor and chief engineer.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... editor and chief engineer. The 13(b)(9) exemption, as was made clear during the debate on the amendment... television stations. It is known at the time of such debate that these stations employ only a small number of...

  10. Chief Diversity Officers' Perceptions of Institutionally Sustainable Diversity Programs

    ERIC Educational Resources Information Center

    Wang, Rong

    2017-01-01

    This exploratory and descriptive study investigated the degree to which a NACUBO Economic Models Project framework is perceived by Chief Diversity Officers (CDOs) as being a relevant tool for sustaining diversity core values in institutional diversity program operations. In response to the rapidly changing demographics of the United States and the…

  11. Suggested Performance Competencies for Chief Student Affairs Officers in Florida.

    ERIC Educational Resources Information Center

    Florida State Dept. of Education, Tallahassee.

    As an informational aid for Florida community college administrators, this manual outlines a set of performance competencies for chief student affairs officers (CSAO's). A professional mission statement for CSAO's is presented first, followed by a brief discussion of the use of the manual in writing job descriptions, selecting candidates for CSAO…

  12. 7 CFR 2.69 - Director, Office of the Chief Scientist.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Director, Office of the Chief Scientist. 2.69 Section 2.69 Agriculture Office of the Secretary of Agriculture DELEGATIONS OF AUTHORITY BY THE SECRETARY OF AGRICULTURE AND GENERAL OFFICERS OF THE DEPARTMENT Delegations of Authority by the Under Secretary for...

  13. NASA Chief Technologist Douglas Terrier Moderates Panel During the AAS 55th Robert H. Goddard Memorial Symposium

    NASA Image and Video Library

    2017-03-08

    NASA Chief Technologist Douglas Terrier moderated the discussion “NASA Leadership in the Future of Science and Technology" during the AAS 55th Robert H. Goddard Memorial Symposium on March 8, 2017. Terrier was joined by Associate Administrator for Space Technology Steve Jurczyk, Chief Scientist Gale Allen and Associate Administrator for Science Thomas Zurbuchen.

  14. NASA Chief Technologist Douglas Terrier Moderates Discussion During the AAS 55th Robert H. Goddard Memorial Symposium

    NASA Image and Video Library

    2017-03-08

    NASA Chief Technologist Douglas Terrier moderated the discussion “NASA Leadership in the Future of Science and Technology" during the AAS 55th Robert H. Goddard Memorial Symposium on March 8, 2017. Terrier was joined by Associate Administrator for Space Technology Steve Jurczyk, Chief Scientist Gale Allen and Associate Administrator for Science Thomas Zurbuchen.

  15. Accounting Support for Preparation of Joint Chiefs of Staff Financial Statements

    DTIC Science & Technology

    1996-03-12

    consolidated financial statements for FY 1996 and each succeeding year. The consolidated DoD financial statements for FY 1996 will include the financial statements for the Joint Chiefs of Staff (JCS). For FY 1994, the JCS received $524 million in appropriated

  16. Connective Heating Improvement for Emergency Fire Shelters (CHIEFS): Composition and Performance of Fire Shelter Concepts at Close-Out

    NASA Technical Reports Server (NTRS)

    Fody, Joshua M.; Daryabeigi, Kamran; Bruce, Walter E., III; Wells, John M.; Wusk, Mary E.; Calomino, Anthony M.; Miller, Steve D.

    2018-01-01

    Summary of highlights of the Convective Heating Improvement for Emergency Fire Shelters (CHIEFS) taskunder NASA. CHIEFS was tasked with providing the US Forest Service with an emergency fire shelter forimproved resistance to flame contact. Emphasis is on the final shelter designs at task close-out (end of FY17).

  17. Surveying the opinions of Pennsylvania Chiefs of Police toward officers carrying and administering naloxone.

    PubMed

    Smyser, Paul A; Lubin, Jeffrey S

    2018-01-01

    Recent legislation in Pennsylvania allows police officers to administer naloxone to individuals in an opioid overdose. Pressure has subsequently been placed on police departments to adopt naloxone programs. To survey Pennsylvania Chiefs of Police regarding potential obstacles to officer-administered naloxone, and their overall opinion toward such programs. A confidential survey was administered at the Annual Conference for the Pennsylvania Chiefs of Police Association and online over the organization's listserv. Respondents rated their level of concern toward four potential obstacles on a Likert scale from 1 to 5. A fifth question asked the degree to which they agree that the benefits of naloxone programs outweigh the risks. Of 180 attendees, 36 Chiefs of Police responded at the conference and 48 to the online survey. The potential agitation of revived victims was their largest reported concern, with 60% responding either a 4 or 5; this was followed by officers correctly identifying situations to use naloxone (42%), the cost of the medication (38%), and the additional administrative duties of the department (32%). Overall 60% responded they "Strongly Agree" or "Agree" the benefits of naloxone programs outweigh the risks, while 23% responded "Strongly Disagree" or "Disagree." No significant differences were seen when separating participants from rural and urban counties or from counties with high, medium, and low rates of overdose fatalities. The results suggest that although a significant subset shows concern for the above obstacles, the majority of Chiefs of Police believe that the benefits of equipping officers with naloxone outweigh the risks.

  18. Audit of the Federal Energy Regulatory Commission`s Office of Chief Accountant

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1995-04-07

    The Federal Energy Regulatory Commission`s (Commission) mission is to oversee America`s natural gas and oil pipeline transportation, electric utility, and hydroelectric power industries to ensure that consumers receive adequate energy supplies at just and reasonable rates. To carry out this mission, the Commission issues regulations covering the accounting, reporting, and rate-making requirements of the regulated utility companies. The Commission`s Office of Chief Accountant performs financial related audits at companies to ensure compliance with these regulations. The purpose of this audit was to evaluate the office of Chief Accountant`s audit performance. Specifically, the objectives were to determine if the most appropriatemore » audit approach was used and if a quality assurance process was in place to ensure reports were accurate and supported by the working papers.« less

  19. The Influence of the CHIEF Pathway on Colorectal Cancer-Specific Mortality

    PubMed Central

    Slattery, Martha L.; Lundgreen, Abbie

    2014-01-01

    Many components of the CHIEF (Convergence of Hormones, Inflammation, and Energy Related Factors) pathway could influence survival given their involvement in cell growth, apoptosis, angiogenesis, and tumor invasion stimulation. We used ARTP (Adaptive Rank Truncation Product) to test if genes in the pathway were associated with colorectal cancer-specific mortality. Colon cancer (n = 1555) and rectal cancer (n = 754) cases were followed over five years. Age, center, stage at diagnosis, and tumor molecular phenotype were considered when calculating ARTP p values. A polygenic risk score was used to summarize the magnitude of risk associated with this pathway. The JAK/STAT/SOC was significant for colon cancer survival (PARTP = 0.035). Fifteen genes (DUSP2, INFGR1, IL6, IRF2, JAK2, MAP3K10, MMP1, NFkB1A, NOS2A, PIK3CA, SEPX1, SMAD3, TLR2, TYK2, and VDR) were associated with colon cancer mortality (PARTP <0.05); JAK2 (PARTP  = 0.0086), PIK3CA (PARTP = 0.0098), and SMAD3 (PARTP = 0.0059) had the strongest associations. Over 40 SNPs were significantly associated with survival within the 15 significant genes (PARTP<0.05). SMAD3 had the strongest association with survival (HRGG 2.46 95% CI 1.44,4.21 PTtrnd = 0.0002). Seven genes (IL2RA, IL8RA, IL8RB, IRF2, RAF1, RUNX3, and SEPX1) were significantly associated with rectal cancer (PARTP<0.05). The HR for colorectal cancer-specific mortality among colon cancer cases in the upper at-risk alleles group was 11.81 (95% CI 7.07, 19. 74) and was 10.99 (95% CI 5.30, 22.78) for rectal cancer. These results suggest that several genes in the CHIEF pathway are important for colorectal cancer survival; the risk associated with the pathway merits validation in other studies. PMID:25541970

  20. Chief Joseph Dam, Columbia River, Washington, Community Impact Reports,

    DTIC Science & Technology

    1980-05-01

    provide a major source of employment. Forested areas in the north and east pro- vide raw materials for an active lumber and wood products industry...Sewage Disposal Systems. The District Engineer of the Washington State Department of Ecology furnished the design flow capacity and its population...latter is without consideration of Chief Joseph Dam contruction impact. The high school is rated 1. 4.03 The individual residents are responsible for

  1. 46 CFR 11.510 - Service requirements for national endorsement as chief engineer of steam, motor, and/or gas...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... engineer of steam, motor, and/or gas turbine-propelled vessels. 11.510 Section 11.510 Shipping COAST GUARD... endorsement as chief engineer of steam, motor, and/or gas turbine-propelled vessels. (a) The minimum service required to qualify an applicant for endorsement as chief engineer of steam, motor, and/or gas turbine...

  2. The Restoration of an Ilkak'mana: A Chief Called Multnomah

    ERIC Educational Resources Information Center

    Fulton, Ann

    2007-01-01

    An ilkak'mana called Multnomah once lived near the river where New England merchants chopped Portland, Oregon, out of a Douglas-fir forest. With a bow and shield slung behind his back, the chief stood imperiously in Hermon A. MacNeil's 1904 statuette inscribed at its base with his name. Nearby tribes preserved Multnomah in words, but years later…

  3. Annual Report 2008 -- Office of the Chief Financial Officer (OCFO)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fernandez, Jeffrey

    2008-12-22

    It is with great pleasure that I present to you the 2008 Chief Financial Officer's Annual Report. The data included in this report has been compiled from the Budget Office, the Controller, Procurement and Property Management and the Sponsored Projects Office. Also included are some financial comparisons with other DOE Laboratories and a glossary of commonly used acronyms.

  4. Joint Chiefs of Staff > Directorates > J1 | Manpower and Personnel

    Science.gov Websites

    Management J1 | Manpower and Personnel J2 | Joint Staff Intelligence J3 | Operations J4 | Logistics► J8 | Force Structure, Resources & Assessment Contact J1 Manpower and Personnel Home : Directorates : J1 | Manpower and Personnel Mission To provide the Chairman of the Joint Chiefs of Staff

  5. Seabrook, N.H. Wastewater Treatment Plant Chief Operator Recognized for Outstanding Service

    EPA Pesticide Factsheets

    Dustin Price, a resident of Berwick Maine and the Chief Operator of the Seabrook, N.H. Wastewater Treatment Plant, was honored by EPA with a 2016 Regional Wastewater Treatment Plant Operator of the Year Excellence Award.

  6. [Determinants in the careers of male and female physicians from the viewpoint of chief physicians].

    PubMed

    Buddeberg-Fischer, B; Spindler, A; Peter, Y; Buddeberg, C

    2003-01-03

    Chief physicians play an important role for physicians' careers by providing advanced training and allocating time and research resources. This study examined which characteristics will help physicians to achieve a leadership position and how chief physicians conduct career promotion. All 532 chief physicians in Switzerland's German speaking cantons with medical schools were approached with a questionnaire covering professional motivation and personal attributes of career-oriented physicians career-promoting personal and institutional factors, and type of career promotion. 207 chief physicians (189 men, 18 women; participation rate 38.9 %;) participated. Respondents rated achievement motivation combined with professional interest and job enjoyment (intrinsic), and interest in advancement and social prestige (extrinsic motivation) as beneficial. Extraprofessional concerns such as family obligations and leisure interests were viewed as less important. Instrumental attributes were rated as advantageous. Expressive qualities were also seen as beneficial but less crucial. Ratings were independent of respondents' age, specialty, or type of workplace. The following personal factors were named: professional commitment, professional and social competence, goal orientation, endurance, and strength of character. The institutional factors referred to quality of training and teaching, a good work atmosphere, a transparent and flexible clinic structure. Career promotion was offered predominantly in the form of coaching, career planning, and support in job search. Career promotion should be more targeted and structured, e. g. be conducted in mentoring programmes, thus providing the prerequisites for a truly equal career promotion of female and male physicians.

  7. Compensation of Chief Executives and Top Earners at 25 Private Universities.

    ERIC Educational Resources Information Center

    Blum, Debra E. Comp.; And Others

    1989-01-01

    A list that shows the compensation of chief executives and five highest-paid employees who are not officers, directors, or trustees of their institutions is presented. Most compensation figures were obtained from federal tax forms that private, tax-exempt colleges and universities must file annually. (MLW)

  8. NASA Chief Technologist Douglas Terrier Moderates a Panel During the AAS 55th Robert H. Goddard Memorial Symposium

    NASA Image and Video Library

    2017-03-08

    NASA Chief Technologist Douglas Terrier moderated the discussion “NASA Leadership in the Future of Science and Technology" during the AAS 55th Robert H. Goddard Memorial Symposium on March 8, 2017. Terrier was joined by Associate Administrator for Space Technology Steve Jurczyk, Chief Scientist Gale Allen and Associate Administrator for Science Thomas Zurbuchen.

  9. NASA Chief Technologist Douglas Terrier Moderates Panel Discussion During the AAS 55th Robert H. Goddard Memorial Symposium

    NASA Image and Video Library

    2017-03-08

    NASA Chief Technologist Douglas Terrier moderated the discussion “NASA Leadership in the Future of Science and Technology" during the AAS 55th Robert H. Goddard Memorial Symposium on March 8, 2017. Terrier was joined by Associate Administrator for Space Technology Steve Jurczyk, Chief Scientist Gale Allen and Associate Administrator for Science Thomas Zurbuchen.

  10. NASA Chief Technologist Douglas Terrier Moderates A Discussion During the AAS 55th Robert H. Goddard Memorial Symposium

    NASA Image and Video Library

    2017-03-08

    NASA Chief Technologist Douglas Terrier moderated the discussion “NASA Leadership in the Future of Science and Technology" during the AAS 55th Robert H. Goddard Memorial Symposium on March 8, 2017. Terrier was joined by Associate Administrator for Space Technology Steve Jurczyk, Chief Scientist Gale Allen and Associate Administrator for Science Thomas Zurbuchen.

  11. The medical librarian as chief information officer.

    PubMed

    Greer, M C

    1998-01-01

    The position of chief information officer (CIO) is gaining popularity, especially in the health care field. The results of an informal electronic and telephone survey indicate that few medical librarians have made a career move to CIO even though this might seem like a logical step. This paper examines the qualities required of an effective information management executive, the role CIOs play within organizations, and the career advancement strategies for librarians interested in becoming CIOs. Questionnaire responses are reported from three medical librarians who have made the transition to CIO-type positions, and a case study illustrates the responsibilities of CIOs in health care organizations.

  12. The Role of the Chief Financial Officer in Large Public Universities.

    ERIC Educational Resources Information Center

    Jenkins, William A.

    1985-01-01

    The characteristics and qualifications of chief financial officers (CFOs) of large public universities, the internal organizational relationships of CFOs, and their responsibilities were studied in 1983. Findings of a similar 1973 study are also considered. A total of 135 usable questionnaire responses provided information on age; sex; length of…

  13. Wearing the crown of Solomon? Chief Justice Roberts and the Affordable Care Act "tax".

    PubMed

    Muise, Robert J; Yerushalmi, David

    2013-04-01

    Attempting to play the role of King Solomon in his PPACA decision, Chief Justice John Roberts split the baby perversely by ruling it was not a tax under the Anti-Injunction Act, which would have likely deprived the Court of jurisdiction to hear this pre-enforcement challenge to the individual mandate, but it was a tax for taxing and spending purposes even though Congress said it was a "penalty" and not a tax. And the Chief Justice had to twist further his "wisdom" to hold that it was not an unconstitutional direct tax, even though that is exactly what it is, if it is a tax in the first instance.

  14. Upper Blackstone Water Pollution Abatement District Chief Operator Recognized for Outstanding Service

    EPA Pesticide Factsheets

    Joseph Nowak, a resident of Ware Mass. and Chief Operator of the Upper Blackstone Water Pollution Abatement District (District) in Milbury, Mass., was honored by EPA with a 2016 Regional Wastewater Treatment Plant Operator of the Year Excellence Award.

  15. Leader of State Chiefs' Group to Step down in August

    ERIC Educational Resources Information Center

    Hoff, David J.

    2006-01-01

    The top executive of the Council of Chief State School Officers (CCSSO) has announced that he will leave his post in 2006 at the end of the summer, giving the group time to plan a lobbying strategy for the reauthorization of the No Child Left Behind Act with a new director. G. Thomas Houlihan, the CCSSO's executive director since 2001, said that…

  16. The California CBO: The 1987-88 Profile of Chief Business Officials in California Public Schools, Kindergarten through Grade Twelve.

    ERIC Educational Resources Information Center

    California State Dept. of Education, Sacramento.

    This report describes the results of a survey designed to provide descriptions of chief business officials (CBOs): their personal characteristics, their career paths, and their preparation. All chief business officials in California K-12 school districts and in offices of county superintendents of schools received questionnaires regarding the CBO…

  17. The Hospital for the Ruptured and Crippled Eugene H. Pool, fourth Surgeon-in-Chief 1933-1935 followed by Philip D. Wilson, fifth Surgeon-in-Chief 1935.

    PubMed

    Levine, David B

    2008-09-01

    In 1933, for the second time in the history of the Hospital for the Ruptured and Crippled (R & C), a general surgeon, Eugene Hillhouse Pool, MD, was appointed Surgeon-in-Chief by the Board of Managers of the New York Society for the Relief of the Ruptured and Crippled. R & C (whose name was changed to the Hospital for Special Surgery in 1940), then the oldest orthopaedic hospital in the country, was losing ground as the leading orthopaedic center in the nation. The R & C Board charged Dr. Pool with the task of recruiting the nation's best orthopaedic surgeon to become the next Surgeon-in-Chief. Phillip D. Wilson, MD, from the Massachusetts General Hospital in Boston and the Harvard Medical School was selected and agreed to accept this challenge. He joined the staff of the Hospital for the Ruptured and Crippled in the spring of 1934 as Director of Surgery and replaced Dr. Pool as Surgeon-in-Chief the next year. It was the time of the Great Depression, which added a heavy financial toll to the daily operations of the hospital. With a clear and courageous vision, Dr. Wilson reorganized the hospital, its staff responsibilities, professional education and care of patients. He established orthopaedic fellowships to support young orthopaedic surgeons interested in conducting research and assisted them with the initiation of their new practices. Recognizing that the treatment of crippling conditions and hernia were becoming separate specialties, one of his first decisions was to restructure the Hernia Department to become the General Surgery Department. His World War I experiences in Europe helped develop his expertise in the fields of fractures, war trauma and amputations, providing a broad foundation in musculoskeletal diseases that was to be beneficial to him in his future role as the leader of R & C.

  18. Equity, Inclusion, and Beyond: Today's Urban Chief Diversity Officer

    ERIC Educational Resources Information Center

    Hancock, Merodie A.

    2018-01-01

    This paper, based primarily on the author's perspective as president of SUNY Empire State College, will explore the need for, and means of leveraging, the chief diversity officer's role in creating an equitable and inclusive environment within the distributed world that is Empire State College's "campus" and, specifically, within SUNY…

  19. The Power of Persuasion: A Model for Effective Political Leadership by State Chiefs. Linking State and Local School Improvement

    ERIC Educational Resources Information Center

    Hill, Paul; Jochim, Ashley

    2017-01-01

    State chiefs have new responsibilities under the Every Student Succeeds Act, but their formal powers are still limited. Despite these constraints, the Center on Reinventing Public Education (CRPE) analysis finds that chiefs can make a difference by wielding their powers strategically, to build coalitions and persuade others. While turnover in the…

  20. Langley Deputy Chief Technologist Julie Williams-Byrd Speaks to Norfolk State University Students

    NASA Image and Video Library

    2018-02-06

    Deputy Chief Technologist Julie Williams-Byrd of NASA Langley Research Center speaks to Norfolk State University students following a “Hidden Figures to Modern Figures” event on February 6, 2018. (Credit: NASA)

  1. The Chief Clinical Informatics Officer (CCIO): AMIA Task Force Report on CCIO Knowledge, Education, and Skillset Requirements.

    PubMed

    Kannry, Joseph; Sengstack, Patricia; Thyvalikakath, Thankam Paul; Poikonen, John; Middleton, Blackford; Payne, Thomas; Lehmann, Christoph U

    2016-01-01

    The emerging operational role of the "Chief Clinical Informatics Officer" (CCIO) remains heterogeneous with individuals deriving from a variety of clinical settings and backgrounds. The CCIO is defined in title, responsibility, and scope of practice by local organizations. The term encompasses the more commonly used Chief Medical Informatics Officer (CMIO) and Chief Nursing Informatics Officer (CNIO) as well as the rarely used Chief Pharmacy Informatics Officer (CPIO) and Chief Dental Informatics Officer (CDIO). The American Medical Informatics Association (AMIA) identified a need to better delineate the knowledge, education, skillsets, and operational scope of the CCIO in an attempt to address the challenges surrounding the professional development and the hiring processes of CCIOs. An AMIA task force developed knowledge, education, and operational skillset recommendations for CCIOs focusing on the common core aspect and describing individual differences based on Clinical Informatics focus. The task force concluded that while the role of the CCIO currently is diverse, a growing body of Clinical Informatics and increasing certification efforts are resulting in increased homogeneity. The task force advised that 1.) To achieve a predictable and desirable skillset, the CCIO must complete clearly defined and specified Clinical Informatics education and training. 2.) Future education and training must reflect the changing body of knowledge and must be guided by changing day-to-day informatics challenges. A better defined and specified education and skillset for all CCIO positions will motivate the CCIO workforce and empower them to perform the job of a 21st century CCIO. Formally educated and trained CCIOs will provide a competitive advantage to their respective enterprise by fully utilizing the power of Informatics science.

  2. Increased matriptase zymogen activation in inflammatory skin disorders

    PubMed Central

    Chen, Cheng-Jueng; Wu, Bai-Yao; Tsao, Pai-In; Chen, Chi-Yung; Wu, Mei-Hsuan; Chan, Yee Lam E.; Lee, Herng-Sheng; Johnson, Michael D.; Eckert, Richard L.; Chen, Ya-Wen; Chou, Fengpai; Lin, Chen-Yong

    2011-01-01

    Matriptase, a type 2 transmembrane serine protease, and its inhibitor hepatocyte growth factor activator inhibitor (HAI)-1 are required for normal epidermal barrier function, and matriptase activity is tightly regulated during this process. We therefore hypothesized that this protease system might be deregulated in skin disease. To test this, we examined the level and activation state of matriptase in examples of 23 human skin disorders. We first examined matriptase and HAI-1 protein distribution in normal epidermis. Matriptase was detected at high levels at cell-cell junctions in the basal layer and spinous layers but was present at minimal levels in the granular layer. HAI-1 was distributed in a similar pattern, except that high-level expression was retained in the granular layer. This pattern of expression was retained in most skin disorders. We next examined the distribution of activated matriptase. Although activated matriptase is not detected in normal epidermis, a dramatic increase is seen in keratinocytes at the site of inflammation in 16 different skin diseases. To gain further evidence that activation is associated with inflammatory stimuli, we challenged HaCaT cells with acidic pH or H2O2 and observed matriptase activation. These findings suggest that inflammation-associated reactive oxygen species and tissue acidity may enhance matriptase activation in some skin diseases. PMID:21123732

  3. EDITORIAL: A word from the new Editor-in-Chief A word from the new Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Mostowski, Jan

    2011-01-01

    TIn the autumn of 2010 I became the Editor-in Chief of European Journal of Physics (EJP). EJP is a place for teachers, instructors and professors to exchange their views on teaching physics at university level and share their experience. It is general opinion that no good research is possible without connection with good, high-quality teaching, at the university level in particular. Therefore excellence in physics teaching is important to the physics community. European Journal of Physics is proud of its contribution to achieving this goal. As Editor-in-Chief, I will continue to work to this general objective of the journal. We will publish articles on specific topics in physics, stressing originality of presentation and suitability for use in students'laboratories, lectures and physics teaching in general. We will also publish more pedagogical papers presenting the achievements of particular teaching methods. In addition, we will continue to publish special sections on particular areas of physics, as well as the annual special section on physics competitions. European Journal of Physics is in good shape. Due to the work of the previous editors and the publisher, the readership is high and growing steadily, and many excellent papers are being submitted and published. I hope that this positive trend for the journal will continue, and I will do my best to keep to this high standard. A few words about myself. I work in the Institute of Physics in Warsaw, Poland. My main research interests are in theoretical quantum optics and I have published about 80 research papers on this topic. For many years I was involved in teaching physics at university and in high school. I am a co-author of a textbook on physics for high-school students and of a problem book in quantum mechanics. For the last ten years, I have been involved in the International Physics Olympiad and over the last few years I have been a member of the Editorial Board of European Journal of Physics.

  4. 46 CFR 11.405 - Service requirements for chief mate of ocean or near-coastal self-propelled vessels of unlimited...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Service requirements for chief mate of ocean or near... of ocean or near-coastal self-propelled vessels of unlimited tonnage. (a) The minimum service required to qualify an applicant for an endorsement as chief mate of ocean or near-coastal self-propelled...

  5. The Joint Chiefs of Staff and National Policy 1951-1953, Volume III, The Korean War: Part Two,

    DTIC Science & Technology

    1998-01-01

    equally by the Commander in Chief, United Nations Com- mand, and the Commander in Chief of the Communist forces in Korea, in num - bers sufficient to...reached on a limiting num - ber that would satisfy General Ridgway’s maximum rotation requirements. The 53 JCS and National Policy important point... sanguine about the success of these efforts.79 The fate of civilian captives of non-ROK origin—missionaries, personnel of neutral embassies, press

  6. 43 CFR 422.6 - Responsibilities of the Chief Law Enforcement Officer.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Responsibilities of the Chief Law Enforcement Officer. 422.6 Section 422.6 Public Lands: Interior Regulations Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR LAW ENFORCEMENT AUTHORITY AT BUREAU OF RECLAMATION PROJECTS Responsibilities § 422.6 Responsibilities of...

  7. 29 CFR 793.11 - Combination announcer, news editor and chief engineer.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Combination announcer, news editor and chief engineer. 793...)(9) OF THE FAIR LABOR STANDARDS ACT Requirements for Exemption § 793.11 Combination announcer, news... as a news editor. In such cases, the primary employment test under the section 13(b)(9) exemption...

  8. 29 CFR 793.11 - Combination announcer, news editor and chief engineer.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Combination announcer, news editor and chief engineer. 793...)(9) OF THE FAIR LABOR STANDARDS ACT Requirements for Exemption § 793.11 Combination announcer, news... as a news editor. In such cases, the primary employment test under the section 13(b)(9) exemption...

  9. 29 CFR 793.11 - Combination announcer, news editor and chief engineer.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Combination announcer, news editor and chief engineer. 793...)(9) OF THE FAIR LABOR STANDARDS ACT Requirements for Exemption § 793.11 Combination announcer, news... as a news editor. In such cases, the primary employment test under the section 13(b)(9) exemption...

  10. 18 CFR 375.304 - Delegations to the Chief Administrative Law Judge.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Delegations to the Chief Administrative Law Judge. 375.304 Section 375.304 Conservation of Power and Water Resources... Law Judge to exercise the power granted to a Presiding Officer by part 385, particularly § 385.504 of...

  11. 18 CFR 375.304 - Delegations to the Chief Administrative Law Judge.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Delegations to the Chief Administrative Law Judge. 375.304 Section 375.304 Conservation of Power and Water Resources... Law Judge to exercise the power granted to a Presiding Officer by part 385, particularly § 385.504 of...

  12. 18 CFR 375.304 - Delegations to the Chief Administrative Law Judge.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Delegations to the Chief Administrative Law Judge. 375.304 Section 375.304 Conservation of Power and Water Resources... Law Judge to exercise the power granted to a Presiding Officer by part 385, particularly § 385.504 of...

  13. 18 CFR 375.304 - Delegations to the Chief Administrative Law Judge.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Delegations to the Chief Administrative Law Judge. 375.304 Section 375.304 Conservation of Power and Water Resources... Law Judge to exercise the power granted to a Presiding Officer by part 385, particularly § 385.504 of...

  14. 18 CFR 375.304 - Delegations to the Chief Administrative Law Judge.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Delegations to the Chief Administrative Law Judge. 375.304 Section 375.304 Conservation of Power and Water Resources... Law Judge to exercise the power granted to a Presiding Officer by part 385, particularly § 385.504 of...

  15. Chief Nursing Officer Survey: BSN and Higher Degree Initiatives in North Carolina.

    PubMed

    Schuler, Mary E; Polly Johnson, Mary P; Stallings, Karen D; Li, Yin

    The purpose of this study was to determine gap areas where North Carolina should implement strategies to promote the Institute of Medicine's recommendation of an 80 percent bachelor of science workforce. The North Carolina Action Coalition sought information about the nursing BSN and higher degree workforce and about human resource policies/strategies that promote BSN and higher degree education. An electronic survey was used to query 120 acute care hospital chief nursing officers over a four-year period and 100 public health chief nursing officers over a two-year period. A majority of acute care and a minority of public health institutions had policies promoting BSN education. Barriers included lack of tuition reimbursement, scheduling/staffing issues, lack of local universities, and a perceived lack of value for nurses. A minority of respondents reported an 80 percent BSN workforce. Strategies are needed statewide to support nursing academic progression.

  16. Factors in adoption of a fire department wellness program: champ-and-chief model.

    PubMed

    Kuehl, Hannah; Mabry, Linda; Elliot, Diane L; Kuehl, Kerry S; Favorite, Kim C

    2013-04-01

    To identify and evaluate determinants of fire departments' wellness program adoption. The Promoting Healthy Lifestyles: Alternative Models' Effects fire service wellness program was offered for free to all medium-sized fire departments in Oregon and Washington. An invitation to participate was mailed to key fire department decision makers (chief, union president, and wellness officer). These key decision makers from 12 sites that adopted the program and 24 matched nonadopting sites were interviewed and results were analyzed to define adoption determinants. Three adoption requirements were identified: (1) mailer connection, (2) local firefighter wellness champion, and (3) willing fire chief, whereas a fourth set of organizational factors had little or no impact on adoption including previous and ongoing wellness activities, financial pressures, and resistance to change. Findings identified determinants of medium-sized fire service wellness program adoption.

  17. 41 CFR 102-173.85 - How long will my application be held, pending approval by the Chief Information Officer (CIO)?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... application be held, pending approval by the Chief Information Officer (CIO)? 102-173.85 Section 102-173.85...) FEDERAL MANAGEMENT REGULATION TELECOMMUNICATIONS 173-INTERNET GOV DOMAIN Registration § 102-173.85 How long will my application be held, pending approval by the Chief Information Officer (CIO...

  18. Balancing Organizational Work with Personal Lives: What Chief Executive Officers Believe

    ERIC Educational Resources Information Center

    Eversole, Barbara A. W.

    2008-01-01

    Chief Executive Officers have an influence on the adoption and implementation of family-friendly initiatives in their organizations, yet little is known about what they believe about the work/life issues of their employees. Often, they themselves are personally removed from the experience of work/family conflict, yet they have a role in supporting…

  19. Moral Judgments of Chief Academic Officers at Institutions of Higher Education

    ERIC Educational Resources Information Center

    Weaver, Megan D.

    2012-01-01

    Chief Academic Officers (CAO) are leaders in institutions of higher education and have wide decision-making scope. Previous research has clearly demonstrated the need for leaders to engage in ethical decision-making. Moral judgments are an aspect of ethical decision-making, so it is important for CAOs to make moral judgments. This study examined…

  20. 49 CFR 604.34 - Chief Counsel decisions and appointment of a PO.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Chief Counsel decisions and appointment of a PO. 604.34 Section 604.34 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CHARTER SERVICE Decisions by FTA and Appointment of a...

  1. The Awakening: The Multicultural Attitudes and Actions of Chief Executive School Officers

    ERIC Educational Resources Information Center

    Boske, Christa

    2007-01-01

    Purpose: The purpose of this study is to examine the interactions among superintendents' chief executive school officers, multicultural attitudes and actions for children from marginalized populations. Design/methodology/approach: Members of the American Association of School Administrators, 945 school superintendents, completed the self-reported,…

  2. The Chief Primary Care Medical Officer: Restoring Continuity

    PubMed Central

    Doohan, Noemi; DeVoe, Jennifer

    2017-01-01

    The year 2016 marked the 20th anniversary of the hospitalist profession, with more than 50,000 physicians identifying as hospitalists. The Achilles heel of hospitalist medicine, however, is discontinuity. Despite many current payment and delivery systems rewarding this discontinuity and severing long-term relationships between patient and primary care teams at the hospital door, primary care does not stop being important when a person is admitted to the hospital. The notion of a broken primary care continuum is not an academic construct, it causes real harm to patients. As a step toward fixing the discontinuity in our health care systems, we propose that every hospital needs a Chief Primary Care Medical Officer (CPCMO), an expert in practice across the spectrum of care. The CPCMO can lead hospital efforts to create systems that ensure primary care’s continuum is complete, while strengthening physician collaboration across specialties, and moving toward achieving the Quadruple Aim of enhancing patient experience, improving population health, reducing costs, and improving the work life of health care providers. For hospitals operating on value-based payment structures, anticipated improvement in measurable outcomes such as decreased length of stay, decreased readmission rates, improved transitions of care, improved patient satisfaction, improved access to primary care, and improved patient health, will enhance the rate of return on the hospital’s investment. The speciality of family medicine should reevaluate our purpose, and reembrace our mission as personal physicians by championing the creation of Chief Primary Care Medical Officers. PMID:28694275

  3. Organization of the Joint Chiefs of Staff and Relationships with the Office of the Secretary of Defense

    DTIC Science & Technology

    1985-05-01

    1958, with respect to the Organization of the Joint Chiefs of Staff and its relationship with the major offices in the Office of the Secretary of...Chiefs of Staff shall avail itself of the views and special skills in the Office of the Secretary of Defense. As a normal procedure, specialized data...necessary for the preparation of such studies shall he obtained from or through the appropriate offices of the Office of the Secretary of Defense. b. The

  4. Archaeological Investigations at Sites 45-OK-250 and 45-OK-4, Chief Joseph Dam Project, Washington.

    DTIC Science & Technology

    1984-01-01

    level behind Chief Joseph Dam. Systematic random sampling using I x I x ’ - 0.1-m collection units in 1 x 1, 1 x 2, or 2 x 2 m cel Is disclosed...ft to the operating pool . level behind Chief Joseph Dam. Systematic random sampling using 1 x 1 x 0.1-i collection units In 1 x 1, 1 x 2, or 2 x 2 m...contingencies under which data were collected , describe data collection and analysis, and organize and summarize data In a torm useful to the widest

  5. The Hospital for the Ruptured and Crippled Eugene H. Pool, Fourth Surgeon-in-Chief 1933–1935 Followed by Philip D. Wilson, Fifth Surgeon-in-Chief 1935

    PubMed Central

    2008-01-01

    In 1933, for the second time in the history of the Hospital for the Ruptured and Crippled (R & C), a general surgeon, Eugene Hillhouse Pool, MD, was appointed Surgeon-in-Chief by the Board of Managers of the New York Society for the Relief of the Ruptured and Crippled. R & C (whose name was changed to the Hospital for Special Surgery in 1940), then the oldest orthopaedic hospital in the country, was losing ground as the leading orthopaedic center in the nation. The R & C Board charged Dr. Pool with the task of recruiting the nation’s best orthopaedic surgeon to become the next Surgeon-in-Chief. Phillip D. Wilson, MD, from the Massachusetts General Hospital in Boston and the Harvard Medical School was selected and agreed to accept this challenge. He joined the staff of the Hospital for the Ruptured and Crippled in the spring of 1934 as Director of Surgery and replaced Dr. Pool as Surgeon-in-Chief the next year. It was the time of the Great Depression, which added a heavy financial toll to the daily operations of the hospital. With a clear and courageous vision, Dr. Wilson reorganized the hospital, its staff responsibilities, professional education and care of patients. He established orthopaedic fellowships to support young orthopaedic surgeons interested in conducting research and assisted them with the initiation of their new practices. Recognizing that the treatment of crippling conditions and hernia were becoming separate specialties, one of his first decisions was to restructure the Hernia Department to become the General Surgery Department. His World War I experiences in Europe helped develop his expertise in the fields of fractures, war trauma and amputations, providing a broad foundation in musculoskeletal diseases that was to be beneficial to him in his future role as the leader of R & C. PMID:18815851

  6. Immunohistochemical localization of hepatopancreatic phospholipase A2 in Hexaplex Trunculus digestive cells

    PubMed Central

    2011-01-01

    Background Mammalian sPLA2-IB localization cell are well characterized. In contrast, much less is known about aquatic primitive ones. The aquatic world contains a wide variety of living species and, hence represents a great potential for discovering new lipolytic enzymes and the mode of digestion of lipid food. Results The marine snail digestive phospholipase A2 (mSDPLA2) has been previously purified from snail hepatopancreas. The specific polyclonal antibodies were prepared and used for immunohistochimical and immunofluorescence analysis in order to determine the cellular location of mSDPLA2. Our results showed essentially that mSDPLA2 was detected inside in specific vesicles tentatively named (mSDPLA2+) granules of the digestive cells. No immunolabelling was observed in secretory zymogene-like cells. This immunocytolocalization indicates that lipid digestion in the snail might occur in specific granules inside the digestive cells. Conclusion The cellular location of mSDPLA2 suggests that intracellular phospholipids digestion, like other food components digestion of snail diet, occurs in these digestive cells. The hepatopancreas of H. trunculus has been pointed out as the main region for digestion, absorption and storage of lipids. PMID:21631952

  7. Immunohistochemical localization of hepatopancreatic phospholipase A2 in Hexaplex trunculus digestive cells.

    PubMed

    Zarai, Zied; Boulais, Nicholas; Karray, Aida; Misery, Laurent; Bezzine, Sofiane; Rebai, Tarek; Gargouri, Youssef; Mejdoub, Hafedh

    2011-06-01

    Mammalian sPLA2-IB localization cell are well characterized. In contrast, much less is known about aquatic primitive ones. The aquatic world contains a wide variety of living species and, hence represents a great potential for discovering new lipolytic enzymes and the mode of digestion of lipid food. The marine snail digestive phospholipase A2 (mSDPLA2) has been previously purified from snail hepatopancreas. The specific polyclonal antibodies were prepared and used for immunohistochimical and immunofluorescence analysis in order to determine the cellular location of mSDPLA2. Our results showed essentially that mSDPLA2 was detected inside in specific vesicles tentatively named (mSDPLA2+) granules of the digestive cells. No immunolabelling was observed in secretory zymogene-like cells. This immunocytolocalization indicates that lipid digestion in the snail might occur in specific granules inside the digestive cells. The cellular location of mSDPLA2 suggests that intracellular phospholipids digestion, like other food components digestion of snail diet, occurs in these digestive cells. The hepatopancreas of H. trunculus has been pointed out as the main region for digestion, absorption and storage of lipids.

  8. Machiavelli's advice to the hospital chief executive officer.

    PubMed

    Papadimos, Thomas J; Marco, Alan P

    2004-01-01

    Hospital chief executive oficers (CEOs) have demanding jobs in which they must, at tims, function as if they are potentates of small principalities. Their ability to elicit loyalty and allegiance, hand out discipline and praise, foster alliances with other organizations, and commit the occasional hostile yet (it is hoped) successful foray onto a competitor's turf are skills that must be mastered for success and longevity. We have taken the thoughts and strategies of the Renaissance political master, Niccolo Machiavelli, and applied them to the modern hospital CEO for whom we feel they still hold elements of wisdom and guidance.

  9. A Review of Chief Information Officer' Main Skills

    NASA Astrophysics Data System (ADS)

    Portela, Luis; Carvalho, Roberto; Varajão, João; Magalhães, Luis

    Information Systems are transforming our lives. Their social and economic impact means opportunities and challenges for people, organizations and governments. Being decisive for competitiveness, they are more and more taken in account by companies, which look at them in order to find a way of improving the business. In this context, the CIO (Chief Information Officer) has a central role, and needs to perform several tasks to ensure that information systems under his supervision are efficient. To be competent in his job, the CIO needs several skills. In this paper, the CIO's main skills are identified and discussed.

  10. EDITORIAL: Greetings from the new Editor-in-Chief Greetings from the new Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Nielsch, Kornelius

    2012-01-01

    On 1 January 2012 I will be assuming the position of Editor-in-Chief of the journal Semiconductor Science and Technology (SST). I am flattered by the confidence expressed in my ability to carry out this challenging job and I will try hard to justify this confidence. The previous Editor-in-Chief, Laurens Molenkamp, University of Würzburg, Germany, has worked tirelessly for the last ten years and has done an excellent job for the journal. Everyone at the journal is profoundly grateful for his leadership and for his achievements In 2012 several new members will join the Editorial Board: Professor Deli Wang (University of California, San Diego) with considerable expertise in semiconductor nanowires, Professor Saskia Fischer (Humboldt University, Berlin, Germany) with a background in semiconductor quantum devices, and Professor Erwin Kessels (Eindhoven University of Technology, Netherlands) with extensive experience in plasma processing of thin films and gate oxides. In particular, I want to express my gratitude to Professor Israel Bar-Joseph (Weizmann Institute of Science, Israel) and Professor Maria Tamargo (The City College of New York, USA), who will leave next year and who have vigorously served the Editorial Board for years. The journal has recently introduced a fast-track option for manuscripts. This option is a high-quality, high-profile outlet for new and important research across all areas of semiconductor research. Authors can expect to receive referee reports in less than 20 days from submission. Once accepted, you can expect the articles to be online within two or three weeks from acceptance and to be published in print in less than a month. Furthermore, all fast-track communications published in 2011 will be free to read for ten years. More detailed information on fast-track publication can be found on the following webpage: http://iopscience.iop.org/0268-1242/page/Fast track communications It is encouraging to see that since the journal introduced pre

  11. Middle States Chief Student Affairs Officer Roles and Succession Planning Considerations

    ERIC Educational Resources Information Center

    Santana, Pedro J.

    2014-01-01

    This study examined chief student affairs officers (CSAOs) within the four-year colleges and universities accredited by the Middle States Commission on Higher Education. The objectives were to: (a) determine the profile of the CSAO; (b) provide a better understanding as to the role of the CSAO; (c) identify the most common career paths taken to…

  12. The Chief Information Officer in Higher Education. Professional Paper Series, #4.

    ERIC Educational Resources Information Center

    Penrod, James I.; And Others

    The monograph examines the literature of the last decade on the rise and role of the Chief Information Officer (CIO) in higher education, business, and health care and reports results of a 1989 survey of higher education CIOs. After a discussion of the origins of the CIO position and concept, chapter 2 presents a survey of the literature,…

  13. Editor in Chief[R] Beginning: Grammar Disasters and Punctuation Faux Pas.

    ERIC Educational Resources Information Center

    Beckwith, Carrie; Block, Cheryl; Broz, Christine; Hockett, Margaret; White, David

    This workbook is designed as an introduction to the "Editor in Chief" series, which reinforces the rules of written English. In this workbook, student first review the rules of grammar and mechanics using multiple-choice questions; then the students learn to apply these rules in context by editing stories in a variety of formats. This "Beginning"…

  14. Choosing a Chief Information Officer: The Myth of the Computer Czar.

    ERIC Educational Resources Information Center

    Fleit, Linda H.

    1986-01-01

    Characteristics of colleges that may indicate the need for a chief information officer (CIO) are identified, along with factors that might lead to failure in taking this direction. An example of an institution that encountered problems when they hired a CIO is included. Factors leading to success are as follows: (1) a well-thought-out position on…

  15. The Chairmanship of the Joint Chiefs of Staff 1949-2016

    DTIC Science & Technology

    2016-01-01

    Distribution Office, Office of the Chief of Naval Operations; the Marine Corps History Division; the Air Force Historical Studies Office; the Pentagon... Studies Group, which came to play a significant role in defin- ing JCS positions but was less successful in winning OSD’s approval of them...force structure issues. To assist in per- forming this function, it recommended additional staff support for him in the studies , analysis, and gaming

  16. An Apprenticeship Rotation Teaches Chief Residents Nontechnical Skills and ACGME Core Competencies.

    PubMed

    Kwakye, Gifty; Chen, Xiaodong Phoenix; Havens, Joaquim M; Irani, Jennifer L; Yule, Steven; Smink, Douglas S

    2015-01-01

    Traditionally, surgical training has used an apprenticeship model but has more recently moved to a service-based model, with groups of residents working with groups of attending surgeons. We developed an apprenticeship rotation to enhance one-on-one interaction between chief residents and selected faculty. We hypothesized that the apprenticeship rotation would be effective for teaching nontechnical skills (NTS) and core competencies. An apprenticeship rotation was created at a university-based surgery residency in which each chief resident selected a single attending surgeon with whom to work exclusively with for a 4-week period. Emphasis was placed on teaching intraoperative NTS as well as the 4 difficult-to-teach Accreditation Council for Graduate Medical Education core competencies (DCC): Interpersonal and Communication Skills, Practice-Based Learning and Improvement, Professionalism, and Systems-Based Practice. Participants were surveyed afterwards about their rotation using a 5-point Likert scale. A Wilcoxon signed rank test was used to compare differences depending on data distribution. All (13/13) the chief residents and 67% (8/12) faculty completed the survey. Overall, 85% of residents and 87.5% of faculty would recommend the rotation to other residents/faculty members. Both residents and faculty reported improvement in trainees' technical skills and NTS. Residents reported improvement in all 4 DCC, particularly, Practice-Based Learning and Improvement, Professionalism, and Interpersonal and Communication Skills. The apprenticeship rotation is an effective means of teaching residents both NTS and DCC essential for independent practice. Consideration should be given to introducing this program into surgical curricula nationally. Copyright © 2015 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

  17. Immunohistochemical localization of hepatopancreatic phospholipase in gastropods mollusc, Littorina littorea and Buccinum undatum digestive cells

    PubMed Central

    2011-01-01

    Background Among the digestive enzymes, phospholipase A2 (PLA2) hydrolyzes the essential dietary phospholipids in marine fish and shellfish. However, we know little about the organs that produce PLA2, and the ontogeny of the PLA2-cells. Accordingly, accurate localization of PLA2 in marine snails might afford a better understanding permitting the control of the quality and composition of diets and the mode of digestion of lipid food. Results We have previously producted an antiserum reacting specifically with mSDPLA2. It labeled zymogen granules of the hepatopancreatic acinar cells and the secretory materials of certain epithelial cells in the depths of epithelial crypts in the hepatopancreas of snail. To confirm this localization a laser capture microdissection was performed targeting stained cells of hepatopancreas tissue sections. A Western blot analysis revealed a strong signal at the expected size (30 kDa), probably corresponding to the PLA2. Conclusions The present results support the presence of two hepatopancreatic intracellular and extracellular PLA2 in the prosobranchs gastropods molluscs, Littorina littorea and Buccinum undatum and bring insights on their localizations. PMID:22114916

  18. The Hospital for Special Surgery 1972–1989; Philip D. Wilson, Jr., Eighth Surgeon-in-Chief

    PubMed Central

    2010-01-01

    After nearly a decade as the seventh Surgeon-in-Chief (1963–1972) of The Hospital for Special Surgery (HSS), Robert Lee Patterson, Jr., MD (1907–1994) retired, having repaired adverse relations between HSS and the New York Hospital-Cornell Medical Center. Patterson, who had first joined the staff of The Hospital for the Ruptured and Crippled in 1936 as a Visiting Surgeon, was able to accomplish this very challenging task mainly through his close relationship with Preston Wade, MD (1901–1982), a general surgeon who had served with Patterson as Co-Chief of the combined New York Hospital-HSS Fracture service. The Board of Trustees of the New York Society for the Relief of the Ruptured and Crippled appointed Philip D. Wilson, Jr. MD, as the eighth Surgeon-in-Chief of The Hospital for Special Surgery. He assumed that office on July 1, 1972. Wilson, who had joined the staff as an Orthopaedic Surgeon to the Out-Patient Department in 1951, had trained as an orthopaedic resident at HSS from 1948 to 1950 and in 1951, finished his residency at the University of California Hospital Medical Center, San Francisco. During his 17 years as Surgeon-in-Chief, he led the hospital into the advanced field of implant research and development and building a world-class center for patient care. Additionally, many other orthopaedic services such as Sports Medicine, Scoliosis and Metabolic Bone Diseases became the leaders in their fields. Supporting Departments of Rheumatology, Anesthesia and others were likewise recognized foremost in the country. PMID:21886524

  19. Transformational Leadership: The Chief Nursing Officer Role in Leading Quality and Patient Safety.

    PubMed

    Jones, Pam; Polancich, Shea; Steaban, Robin; Feistritzer, Nancye; Poe, Terri

    This department column highlights leadership perspectives of quality and patient safety practice. The purpose of this article is to provide strategic direction for transformational quality and safety leadership as the chief nursing officer (CNO) within the academic medical center environment.

  20. NASA Chief Technologist See Technology with Norfolk State University Associate Professor Rasha Morsi

    NASA Image and Video Library

    2018-02-06

    Norfolk State University Associate Professor Rasha Morsi showcases a phone operated, 3D-printed robot sign language interpreter to NASA Chief Technologist Douglas Terrier during a tour of the university’s Creative Gaming Simulation lab on February 6, 2018. (Credit: NASA)

  1. Office of the Chief Financial Officer Strategic Plan2008-2012

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Various

    2007-11-19

    This is an update to the Office of the Chief Financial Officer's (OCFO's) multi-year strategy to continue to build a highly effective, efficient and compliant financial and business approach to support the scientific mission of Lawrence Berkeley National Laboratory (LBNL). The guiding principles of this strategy are to provide the greatest capability for the least cost while continually raising the standards of professional financial management in service to the LBNL science mission.

  2. Women Chief Housing Officers at State Universities in the Northwest United States

    ERIC Educational Resources Information Center

    Hyatt, Jennifer Leigh

    2016-01-01

    This qualitative study explored the experiences of women chief housing officers (CHOs) at state universities within the northwest region of the United States. The study used narrative inquiry methodology with a thematic analysis approach to investigate how seven female CHOs experience and make meaning of their professional career progression and…

  3. The Journey to an Inaugural Chief Diversity Officer: Preparation, Implementation and Beyond

    ERIC Educational Resources Information Center

    Arnold, Jeanne; Kowalski-Braun, Marlene

    2012-01-01

    In this article, we discuss the necessary components for successfully creating and implementing a chief diversity officer (CDO) position within a four-year public institution. We explore information about critical stages of the process such as the creation of the position, the recruitment process, and compatibility with the institution's mission.…

  4. Chief Academic Officers at Black Colleges and Universities: A Comparison by Gender.

    ERIC Educational Resources Information Center

    Williams, Lea E.

    1986-01-01

    Causes of women's underrepresentation among education administrators are explored. The following points are considered: (1) career paths of men and women chief academic officers (CAOs); (2) career aspirations; (3) responsibilities of male and female CAOs; (4) general profile of men and women CAOs; (5) salaries and compensation inequities; and (6)…

  5. Reducing Firearm-Related Violence on College Campuses--Police Chiefs' Perceptions and Practices

    ERIC Educational Resources Information Center

    Thompson, Amy; Price, James H.; Mrdjenovich, Adam J.; Khubchandani, Jagdish

    2009-01-01

    Context: Firearms are used in the majority of college aged suicides and homicides. With recent efforts by various gun lobbying groups to have firearms more accessible to college students on campuses, there is the potential for more firearm-related morbidity and mortality. Objective: This study assessed university police chiefs' perceptions and…

  6. Chief Dull Knife Community Is Strengthening the Northern Cheyenne Language and Culture.

    ERIC Educational Resources Information Center

    Littlebear, Richard E.

    2003-01-01

    Language revitalization programs should focus on whether they want to teach the language, teach about the language, teach with the language, or teach the language for academic credit. A program at Chief Dull Knife College (Montana) teaches the Cheyenne language using the Total Physical Response method, which replicates the manner in which first…

  7. Diversity Work in Contentious Times: The Role of The Chief Diversity Officer

    ERIC Educational Resources Information Center

    Wong, Kathleen

    2017-01-01

    Following the 2016 presidential election, the author, the chief diversity officer at San José State University (SJSU), began receiving calls from professors who were anxious about facilitating discussions in their classrooms. At SJSU, a significant number of students were upset by--and fearful about-- incidents of hate and harassment nationwide,…

  8. The usefulness of chief complaints to predict severity, ventilator dependence, treatment option, and short-term outcome of patients with Guillain-Barré syndrome: a retrospective study.

    PubMed

    Wang, Ying; Shang, Pei; Xin, Meiying; Bai, Jing; Zhou, Chunkui; Zhang, Hong-Liang

    2017-11-21

    It remains an urgent need for early recognition of disease severity, treatment option and outcome of Guillain-Barré syndrome (GBS). The chief complaint may be quickly obtained in clinic and is one of the candidates for early predictors. However, studies on the chief complaint are still lacking in GBS. The aim of the study is to describe the components of chief complaints of GBS patients, and to explore association between chief complaints and disease severity/treatment option/outcome of GBS, so as to aid the early prediction of the disease course and to assist the clinicians to prescribe an optimal early treatment. A total of 523 GBS patients admitted to the First Hospital of Jilin University from 2003 to 2013 were enrolled for retrospective analysis. The data of chief complaints, clinical manifestations, and treatment options, etc. were collected. The clinical severity was evaluated by the Medical Research Council sum score and the Hughes Functional Grading Scale. The prognosis at 6 month after discharge was described by modified Erasmus GBS outcome score. The clinic GBS severity evaluation scale (CGSES), a newly established model in our study, was used to explore the role of chief complaints to predict intravenous immunoglobulin (IVIg). The major components of the chief complaints of GBS patients were weakness, numbness, pain, cranial nerve involvement, dyspnea, ataxia and autonomic dysfunction. Chief complaint of weakness was a predictor of severe disease course and poor short-term outcome, while chief complaint of numbness and cranial nerve involvement were promising predictors. Cranial nerve involvement was the predictor of ventilator dependence. The percentages of 366 GBS patients, who need IVIg treatment at nadir with CGSES ranging from 1 to 4, were 50.00, 67.34, 80.61, and 90.67%, respectively. Chief complaints are clinic predictors of disease severity, ventilator dependence and short-term outcome. IVIg treatment during hospitalisation could be predicted

  9. A Convenient Model of Severe, High Incidence Autoimmune Gastritis Caused by Polyclonal Effector T Cells and without Perturbation of Regulatory T Cells

    PubMed Central

    Tu, Eric; Ang, Desmond K. Y.; Hogan, Thea V.; Read, Simon; Chia, Cheryl P. Z.; Gleeson, Paul A.; van Driel, Ian R.

    2011-01-01

    Autoimmune gastritis results from the breakdown of T cell tolerance to the gastric H+/K+ ATPase. The gastric H+/K+ ATPase is responsible for the acidification of gastric juice and consists of an α subunit (H/Kα) and a β subunit (H/Kβ). Here we show that CD4+ T cells from H/Kα-deficient mice (H/Kα−/−) are highly pathogenic and autoimmune gastritis can be induced in sublethally irradiated wildtype mice by adoptive transfer of unfractionated CD4+ T cells from H/Kα−/− mice. All recipient mice consistently developed the most severe form of autoimmune gastritis 8 weeks after the transfer, featuring hypertrophy of the gastric mucosa, complete depletion of the parietal and zymogenic cells, and presence of autoantibodies to H+/K+ ATPase in the serum. Furthermore, we demonstrated that the disease significantly affected stomach weight and stomach pH of recipient mice. Depletion of parietal cells in this disease model required the presence of both H/Kα and H/Kβ since transfer of H/Kα−/− CD4+ T cells did not result in depletion of parietal cells in H/Kα−/− or H/Kβ−/− recipient mice. The consistency of disease severity, the use of polyclonal T cells and a specific T cell response to the gastric autoantigen make this an ideal disease model for the study of many aspects of organ-specific autoimmunity including prevention and treatment of the disease. PMID:22096532

  10. Glen Henshaw Briefs NASA Chief and Deputy Chief Technologists at the In-Space Assembly Technical Interchange Meeting on September 6, 2017

    NASA Image and Video Library

    2017-09-06

    WASHINGTON, D.C.---S&T Partnership Forum In-Space Assembly Technical Interchange Meeting-On September 6th 2017, many of the United States government experts on In-Space Assembly met at the U.S. Naval Research Lab to discuss both technology development and in-space applications that would advance national capabilities in this area. Expertise from NASA, USAF, NRO, DARPA and NRL met in this meeting which was coordinated by the NASA Headquarters, Office of the Chief Technologist. This technical interchange meeting was the second meeting of the members of this Science and Technology Partnership Forum. Glen Henshaw of Code 8231 talks to the group in the Space Robotics Lab.

  11. Chief Academic Officers and Gateway Courses: Keys to Institutional Retention and Persistence Agendas

    ERIC Educational Resources Information Center

    Matthews, Roberta S.; Newman, Scott

    2017-01-01

    Among persistence and retention agenda initiatives undertaken by colleges and universities, gateway-course improvement efforts are often overlooked. However, the engagement of diverse institutional stakeholders in the transformation of gateway courses can contribute significantly to student success. Chief academic officers are in a unique position…

  12. NASA Acting Deputy Chief Technologist Briefed on Operation of Sonic Boom Prediction Algorithms

    NASA Image and Video Library

    2017-08-29

    NASA Acting Deputy Chief Technologist Vicki Crips being briefed by Tim Cox, Controls Engineer at NASA’s Armstrong Flight Research Center at Edwards, California, on the operation of the sonic boom prediction algorithms being used in engineering simulation for the NASA Supersonic Quest program.

  13. Chief Student Affairs Officers' Perceptions of Institutional Crisis Management, Preparedness, and Response

    ERIC Educational Resources Information Center

    Studenberg, Heather Nicole Lancin

    2017-01-01

    This dissertation examined chief student affairs officers' perceptions of institutional crisis management, preparedness, and response. A goal of this study was to uncover findings that can benefit crisis management protocols or best practices regarding crisis management team training, plan communications, and emergency management personnel on…

  14. Corporate Giving: The Views of Chief Executive Officers of Major American Corporations.

    ERIC Educational Resources Information Center

    White, Arthur H.; Bartolomeo, John S.

    The attitudes of chief executive officers (CEO's) of a sample of major U.S. corporations toward corporate philanthropy were surveyed. The sample consisted of 69 Fortune 1300 companies, 73 companies with $50 to $100 million annual sales volume, and 77 companies with $25 to $49 million annual sales volume. Attention was directed to current giving…

  15. A Photographic Essay of Apache Chiefs and Warriors, Volume 2-Part B.

    ERIC Educational Resources Information Center

    Barkan, Gerald; Jacobs, Ben

    As part of a series designed for instruction of American Indian children and youth, this resource guide constitutes a pictorial essay describing forts, Indian agents, and Apache chiefs, warriors, and scouts of the 19th century. Accompanying each picture is a brief historical-biographical narrative. Focus is on Apache resistance to the reservation.…

  16. Charge-Triggered Membrane Insertion of Matrix Metalloproteinase-7, Supporter of Innate Immunity and Tumors.

    PubMed

    Prior, Stephen H; Fulcher, Yan G; Koppisetti, Rama K; Jurkevich, Alexander; Van Doren, Steven R

    2015-11-03

    Matrix metalloproteinase-7 (MMP-7) sheds signaling proteins from cell surfaces to activate bacterial killing, wound healing, and tumorigenesis. The mechanism targeting soluble MMP-7 to membranes has been investigated. Nuclear magnetic resonance structures of the zymogen, free and bound to membrane mimics without and with anionic lipid, reveal peripheral binding to bilayers through paramagnetic relaxation enhancements. Addition of cholesterol sulfate partially embeds the protease in the bilayer, restricts its diffusion, and tips the active site away from the bilayer. Its insertion of hydrophobic residues organizes the lipids, pushing the head groups and sterol sulfate outward toward the enzyme's positive charge on the periphery of the enlarged interface. Fluorescence probing demonstrates a similar mode of binding to plasma membranes and internalized vesicles of colon cancer cells. Binding of bilayered micelles induces allosteric activation and conformational change in the auto-inhibitory peptide and the adjacent scissile site, illustrating a potential intermediate in the activation of the zymogen. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. PGE2 induces oenocytoid cell lysis via a G protein-coupled receptor in the beet armyworm, Spodoptera exigua

    USDA-ARS?s Scientific Manuscript database

    Eicosanoids mediate cellular and humoral immune responses in the beet armyworm, Spodoptera exigua, including activation of prophenoloxidase (PPO). PPO activation begins with release of its inactive zymogen, PPO, from oenocytoids in response to prostaglandins (PGs). Based on the biomedical literatur...

  18. More than Messages: The Role and Function of Today's Chief Marketing Officer

    ERIC Educational Resources Information Center

    Sevier, Robert A.

    2004-01-01

    Few positions on a college campus have evolved more than that of the chief marketing officer (CMO). Even a few years ago, this person, and position, did not exist. Of late, however, as colleges and universities have begun to appreciate the potential that integrated marketing communications has to offer them, more and more institutions have begun…

  19. Reexamining Joint Chiefs of Staff Involvement in the Bay of Pigs

    DTIC Science & Technology

    2015-05-21

    judged the guerilla plan to be unsound and had recommended improvements. Short of further assurances, the JCS had no way to confirm that the CIA had...Approved for public release; distribution is unlimited Reexamining Joint Chiefs of Staff Involvement in the Bay of Pigs A Monograph by LTC...average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data

  20. Fostering the Intellectual and Tribal Spirit: The Role of the Chief Academic Officer

    ERIC Educational Resources Information Center

    His Horse Is Thunder, Deborah

    2015-01-01

    This article introduces and describes the academic leadership role of the chief academic officer (CAO), also referred to as the academic vice-president, academic dean, or the provost. The CAO is responsible for the development and implementation of all academic programs, including the curriculum content, assessment, instruction quality,…

  1. 14 CFR 385.18 - Authority of the Chief, Coordination Section, Documentary Services Division.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Authority of the Chief, Coordination Section, Documentary Services Division. 385.18 Section 385.18 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ORGANIZATION STAFF ASSIGNMENTS AND REVIEW OF ACTION UNDER ASSIGNMENTS Assignment of Functions...

  2. 14 CFR 385.18 - Authority of the Chief, Coordination Section, Documentary Services Division.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Authority of the Chief, Coordination Section, Documentary Services Division. 385.18 Section 385.18 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ORGANIZATION STAFF ASSIGNMENTS AND REVIEW OF ACTION UNDER ASSIGNMENTS Assignment of Functions...

  3. 14 CFR 385.18 - Authority of the Chief, Coordination Section, Documentary Services Division.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Authority of the Chief, Coordination Section, Documentary Services Division. 385.18 Section 385.18 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ORGANIZATION STAFF ASSIGNMENTS AND REVIEW OF ACTION UNDER ASSIGNMENTS Assignment of Functions...

  4. 14 CFR 385.18 - Authority of the Chief, Coordination Section, Documentary Services Division.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Authority of the Chief, Coordination Section, Documentary Services Division. 385.18 Section 385.18 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ORGANIZATION STAFF ASSIGNMENTS AND REVIEW OF ACTION UNDER ASSIGNMENTS Assignment of Functions...

  5. 14 CFR 385.18 - Authority of the Chief, Coordination Section, Documentary Services Division.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Authority of the Chief, Coordination Section, Documentary Services Division. 385.18 Section 385.18 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ORGANIZATION STAFF ASSIGNMENTS AND REVIEW OF ACTION UNDER ASSIGNMENTS Assignment of Functions...

  6. Chief Executive Officer Power Message Types as a Function of Organizational Target Types.

    ERIC Educational Resources Information Center

    Freiberg, Kevin L.; Hellweg, Susan A.

    To explore the specific types of power that emerge in the communication messages chief executive officers (CEOs) use when interacting with others--particularly superiors, peers, and subordinates--15 CEOs were asked to respond to three hypothetical situations. During 60-minute tape-recorded interviews, they were asked what they would say to…

  7. The Intersections and Impact of Professional Development for Women Chief Student Affairs Officers

    ERIC Educational Resources Information Center

    Wegner, Jennifer

    2017-01-01

    Professional development is learner-centered, where the responsibility to engage in further educational experiences belongs to the individual and is a critical way to prepare for career advancement. In higher education, cisgender women do not hold the majority of chief student affairs officers (CSAO) positions, which is unexpected given their…

  8. 49 CFR 1.33 - Assistant Secretary for Budget and Programs and Chief Financial Officer.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Programs and CFO, in consultation with the Chief Information Officer, may designate any information technology system as a financial management system under the CFO's policy and oversight area of... oversight and policy guidance for all budget, financial management, program performance, and internal...

  9. 49 CFR 1.33 - Assistant Secretary for Budget and Programs and Chief Financial Officer.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Programs and CFO, in consultation with the Chief Information Officer, may designate any information technology system as a financial management system under the CFO's policy and oversight area of... oversight and policy guidance for all budget, financial management, program performance, and internal...

  10. 49 CFR 1.33 - Assistant Secretary for Budget and Programs and Chief Financial Officer.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Programs and CFO, in consultation with the Chief Information Officer, may designate any information technology system as a financial management system under the CFO's policy and oversight area of... oversight and policy guidance for all budget, financial management, program performance, and internal...

  11. 2010 Department of Defense Chief Freedom of Information Act Officer Report

    DTIC Science & Technology

    2010-03-19

    of the Joint Chiefs of Staff (CJCS) has over 15,000 followers on Twitter and one of the most downloaded podcasts on the Pentagon Channel iTunes site...nutrition, recipes, and a link to ask a question of the DeCA Dietician; information concerning customer service, including patron councils, comment cards ...DFAS Financial Integrated Systems Services II contracts and the DFAS Impact Card Holder listing. IV. Steps Taken To Greater Utilize Technology

  12. Emergency Department Chief Complaint and Diagnosis Data to Detect Influenza-Like Illness with an Electronic Medical Record

    PubMed Central

    May, Larissa S.; Griffin, Beth Ann; Bauers, Nicole Maier; Jain, Arvind; Mitchum, Marsha; Sikka, Neal; Carim, Marianne; Stoto, Michael A.

    2010-01-01

    Background: The purpose of syndromic surveillance is early detection of a disease outbreak. Such systems rely on the earliest data, usually chief complaint. The growing use of electronic medical records (EMR) raises the possibility that other data, such as emergency department (ED) diagnosis, may provide more specific information without significant delay, and might be more effective in detecting outbreaks if mechanisms are in place to monitor and report these data. Objective: The purpose of this study is to characterize the added value of the primary ICD-9 diagnosis assigned at the time of ED disposition compared to the chief complaint for patients with influenza-like illness (ILI). Methods: The study was a retrospective analysis of the EMR of a single urban, academic ED with an annual census of over 60, 000 patients per year from June 2005 through May 2006. We evaluate the objective in two ways. First, we characterize the proportion of patients whose ED diagnosis is inconsistent with their chief complaint and the variation by complaint. Second, by comparing time series and applying syndromic detection algorithms, we determine which complaints and diagnoses are the best indicators for the start of the influenza season when compared to the Centers for Disease Control regional data for Influenza-Like Illness for the 2005 to 2006 influenza season using three syndromic surveillance algorithms: univariate cumulative sum (CUSUM), exponentially weighted CUSUM, and multivariate CUSUM. Results: In the first analysis, 29% of patients had a different diagnosis at the time of disposition than suggested by their chief complaint. In the second analysis, complaints and diagnoses consistent with pneumonia, viral illness and upper respiratory infection were together found to be good indicators of the start of the influenza season based on temporal comparison with regional data. In all examples, the diagnosis data outperformed the chief-complaint data. Conclusion: Both analyses

  13. Chief Student Affairs Officers in 2-Year Colleges: Their Demographics and Educational Backgrounds

    ERIC Educational Resources Information Center

    Keim, Marybelle C.

    2008-01-01

    The purpose of this study was to determine demographics and educational backgrounds of chief student affairs officers (CSAOs) in public 2-year colleges. Using systematic sampling techniques, 300 2-year colleges were selected from the AACC Membership Directory for inclusion in the study. Each college's website was visited to determine the name of…

  14. Becoming a Chief Librarian: An Analysis of Transition Stages in Academic Library Leadership.

    ERIC Educational Resources Information Center

    Matthews, Catherine J.

    2002-01-01

    Explores how the four-part model of transition cycles applies to becoming a chief librarian of an academic library. Considers the four stages from various organizational levels, as well as for their psychological and social impact on the new job incumbent, and presents an instrument for assessment of transitional success. (Author/LRW)

  15. The Relationship between Chief Information Officer Transformational Leadership and Computing Platform Operating Systems

    ERIC Educational Resources Information Center

    Anderson, George W.

    2010-01-01

    The purpose of this study was to relate the strength of Chief Information Officer (CIO) transformational leadership behaviors to 1 of 5 computing platform operating systems (OSs) that may be selected for a firm's Enterprise Resource Planning (ERP) business system. Research shows executive leader behaviors may promote innovation through the use of…

  16. Using 3D acoustic telemetry to assess the response of resident salmonids to strobe lights in Lake Roosevelt, Washington: Chief Joseph Kokanee Enhancement Feasibility Study, 2001-2002 annual report

    USGS Publications Warehouse

    Perry, R.W.; Farley, M.J.; Hansen, G.S.; Shurtleff, D.J.; Rondorf, D.W.; LeCaire, R.

    2003-01-01

    In 1995, the Chief Joseph Kokanee Enhancement Project was established to mitigate the loss of anadromous fish due to the construction of Chief Joseph and Grand Coulee dams. The objectives of the Chief Joseph Enhancement Project are to determine the status of resident kokanee (Oncorhynchus nerka) populations above Chief Joseph and Grand Coulee dams and to enhance kokanee and rainbow trout (Oncorhynchus mykiss) populations. Studies conducted at Grand Coulee Dam documented substantial entrainment of kokanee through turbines at the third powerhouse.

  17. Chief nurse executives' balance of their work and personal lives.

    PubMed

    Borman, J S

    1993-01-01

    Stress among chief nurse executives (CNEs) can result from the desire to meet work-related responsibilities and maintain a satisfying personal life. The purpose of this research was to determine if the stress level that results from balancing work-related and personal-life time pressures differs among CNEs by gender. CNEs experienced moderate levels of strain; gender differences were apparent. The research findings demonstrate that the influence of gender within a female-dominated profession is consistent not with the gender norms of females, but with the gender norms seen within the larger society.

  18. Is chief executive officer turnover good for the hospital?

    PubMed

    Khaliq, Amir A; Walston, Stephen L; Thompson, David M

    2007-01-01

    This study examined the general characteristics of chief executive officers (CEOs) and their hospitals and the perceived impact of CEO turnover on various organizational activities. A mail-based survey included 156 hospital CEOs in 6 states in the West South Central, West North Central, and Mountain regions. Neither hospital and CEO characteristics nor the impact on various organizational activities and performance indicators was significantly different among the 6 states compared. Overall, CEOs reported relatively short tenures, frequent promotion from within the organization to CEO level, and common involuntary departure of their predecessors. Respondents overwhelmingly reported a positive impact of leadership change on financial performance, employee morale, and organizational culture.

  19. Know your audience: analysis of chief complaints at clinica esperanza, a student-run free clinic in memphis, tennessee.

    PubMed

    Cesari, Whitney A; Vaikunth, Sumeet S; Lewis, Jim B; Panda, Mukta

    2012-10-01

    To identify the chief complaints and demographics at Clinica Esperanza, a student-run free clinic for an underserved Hispanic population. A retrospective chart review of patient files from 2005 through 2010 was undertaken, as approved by the University of Tennessee Health Science Center's Institutional Review Board. From 2005 through 2010, Clinica Esperanza fielded 2551 patient visits, consisting of 951 unique patients, 609 females and 342 males. Mean age was 34 years, and 60% of patients presented once, while 13% followed up for 1 year, 9% for 2 years, 6% for 3, 6% for 4, and 4% for 5. "Pap smear," "abdominal pain," and "follow-up lab results" ranked, in order, as the 3 top chief complaints. Resulting data have led to several improvements. The clinic has remained open weekly to improve patient continuity. With the top 10 chief complaints identified, they are better addressed. More funding is allocated for speculums and proper training of Pap smear technique. Systematic reporting of lab results is being implemented. Physical therapists and pharmacists now participate to address musculoskeletal and medication-based needs, respectively. A volunteer gastroenterologist has been recruited to provide specialized care for abdominal pain. An electrocardiogram machine is now used to evaluate chest pain. To improve student-patient communication, online language learning modules have been created. Based on these data, improvements in health care services have been made, including better continuity, emphasis on top chief complaints, and provider education in medical Spanish. Future plans include on-site pharmacy, smoother referrals, and similar clinics on the University of Tennessee Health Science Center's other campuses.

  20. 75 FR 52518 - Meeting of the Chief of Naval Operations (CNO) Executive Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ...The Chief of Naval Operations (CNO) Executive Panel will report on the findings and recommendations of the Cyber Warfare Subcommittee to the CNO. The meeting will consist of discussions of current and future Navy strategy, plans, and policies in support of the organizing, manning, training, and equipping of Cyber Warfare forces for current and future operations.

  1. From Bunker to Building: Results from the 2010 Chief Human Resource Officer Survey

    ERIC Educational Resources Information Center

    Wright, Patrick M.; Stewart, Mark

    2011-01-01

    In 2009, the researchers, with funding from the Center for Advanced Human Resource Studies (CAHRS), began conducting the annual Chief Human Resource Officers (CHRO) Survey. The 2009 survey was sent to CHROs at the U.S. Fortune 150 companies, as well as to ten other CHROs at CAHRS partner companies. That survey focused on understanding how CHROs…

  2. 33 CFR 211.13 - Approval of the Office of the Chief of Engineers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Approval of the Office of the Chief of Engineers. 211.13 Section 211.13 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS PROJECTS Disposal of Real Estate...

  3. 77 FR 63835 - Office of the Chief Information Officer; Submission for OMB Review; Temporary Contractor...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... of the Chief Information Officer; Submission for OMB Review; Temporary Contractor Information... information collection requirement regarding temporary contractor information worksheet. A notice was... for temporary contractors as a result of the American Recovery and Reinvestment Act of 2009 (Public...

  4. What Do We Teach Psychiatric Residents about Suicide? A National Survey of Chief Residents

    ERIC Educational Resources Information Center

    Melton, Bengi B.; Coverdale, John H.

    2009-01-01

    Objective: Because of the clinical significance of patient suicide for trainees and current limited information on this essential educational subject, the authors sought to determine what topics involving the care of suicidal patients were taught to residents in psychiatry training programs. Methods: Chief residents of psychiatry training programs…

  5. Chief Diversity Officers in U.S. Higher Education: Impacting the Campus Climate for Diversity

    ERIC Educational Resources Information Center

    Mednick Takami, Lisa

    2017-01-01

    Chief Diversity Officers remain a relatively new phenomenon among higher education executive leadership positions. Existing literature on CDOs' professional profile, their ability to impact campus climate for diversity, and their obstacles in the pursuit of campus climate change and deeper cultural transformation is still quite limited. This basic…

  6. Wildlife Habitat Impact Assessment, Chief Joseph Dam Project, Washington : Project Report 1992.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kuehn, Douglas; Berger, Matthew

    1992-01-01

    Under the Pacific Northwest Electric Power Planning and Conservation Act of 1980, and the subsequent Northwest Power Planning Council`s Columbia River Basin Fish and Wildlife Program, a wildlife habitat impact assessment and identification of mitigation objectives have been developed for the US Army Corps of Engineer`s Chief Joseph Dam Project in north-central Washington. This study will form the basis for future mitigation planning and implementation.

  7. The role of the chief marketing executive in hospitals. A survey.

    PubMed

    Wagle, J S; Kizilbash, A H

    1987-05-01

    The role and support for the Chief Marketing Executive (CME) in hospitals is studies through a 97 hospital survey. The authors found that the majority of CMEs report at a high level in the organization, but their staffs are still small and their duties diverse. However, the budgets for advertising and market research are increasing. The authors anticipate the CME's role to continue evolving into a strategist as hospitals define more clearly the CME's duties and recognize marketing's contribution to the organization.

  8. Strategies for Institutional Transformation: A Multi-Case Study of the Chief Diversity Officer Position

    ERIC Educational Resources Information Center

    Leon, Raul Alejandro

    2010-01-01

    This study is concerned with the fact that many colleges and universities have adopted strategic diversity plans, but many still fall short of reaping the benefits that diversity brings to the college environment (Milem, Chang, & Antonio, 2005). Today, several colleges and universities have developed a chief diversity officer (CDO) position to…

  9. Female College Presidents: Characteristics to Become and Remain Chief Executive Officer of a College

    ERIC Educational Resources Information Center

    Balram, Arlette

    2012-01-01

    Through an ethnographic approach, the perceptions of female college presidents from the northeastern region of the United States regarding leadership styles and the characteristics to become and remain the chief executive officer of a college were investigated. Six presidents from various types of four-year colleges were interviewed. Themes,…

  10. Leadership Characteristics for Health Care Managers: Perspectives of Chief Executive Officers in US Hospitals.

    PubMed

    Collins, Sandra K; McKinnies, Richard; Collins, Kevin S

    2015-01-01

    A study was conducted to determine the perceptions of chief executive officers in US hospitals regarding the most important characteristics aspiring health care executives should possess. The results of this 2012 study were compared with a previous study conducted in 2007 to determine if the perceptions had changed over time.

  11. Office of the Chief Financial Officer 2012 Annual Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Williams, Kim

    2013-01-31

    Fiscal Year 2012 was a year of progress and change in the Office of the Chief Financial Officer (OCFO) organization. The notable accomplishments outlined below strengthened the quality of the OCFO’s stewardship and services in support of the scientific mission of Lawrence Berkeley National Laboratory (LBNL). Three strategies were key to this progress: organizational transformation aligned with our goals; process redesign and effective use of technology to improve efficiency, and innovative solutions to meet new challenges. Over the next year we will continue to apply these strategies to further enhance our contributions to the Lab’s scientific mission. What follows ismore » the budget, funding and costs for the office for FY 2012.« less

  12. [Stanisława Adamowiczowa--first editor in-chief of Journal "Przeglad Epidemiologiczny"].

    PubMed

    Gromulska, Marta

    2010-01-01

    First issue of Epidemiological Review was published in 1920. First editor in chief was Stanisława Adamowiczowa, PhD (1888-1965), who had worked in National Central Epidemiological Institute since 1919, and later, for period of 45 years, interrupted by breaks resulting from political situation, worked in National Institute of Hygiene. In this jubilee article, we present scientific resume of S. Adamowiczowa which focuses on her achievements in infectious diseases epidemiology, and particularly in analysis and evaluation of current epidemiological data distribution in Poland and worldwide in the period. She was the pioneer in systemic organization of registries of new cases of diseases in the highly populated Polish cities; she initiated use of statistical methods in this field. As editor in chief of Epidemiological Review, she started publishing Epidemiological Chronicle, which is continuously added as a supplement to every second issue, each year. Name of S. Adamowiczowa is associated with Ludwik Rajchman--director of Hygiene Section in League of Nations, with Witold Chodźko PhD--she led courses in National School of Hygiene in Warsaw, with prof. Marcin Kacprzak--as co-author and co-editor of books on hygiene and epidemiology. A brief list of scientific publications of S. Adamowiczowa is also presented.

  13. Chief medical officer actions on information security in an Italian rehabilitation centre.

    PubMed

    Reni, Gianluigi; Molteni, Massimo; Arlotti, Stefano; Pinciroli, Francesco

    2004-03-31

    In a multi-speciality rehabilitation centre, where child neuropsychiatrists, neurologists, physical rehabilitators, psychologists, nurses, therapists and other health care professionals actively care for patients, the moment will arrive when information security takes high priority on the chief medical officer (CMO) agenda. This has happened at the La Nostra Famiglia Institution. Local push to high priority arose from several concurrent forces, like privacy both on the patient and on the doctor side, legal and ethical aspects. Recommendations on the protection of medical data require appropriate technical and organisational measures to be taken to protect personal data against unauthorised access, alterations or any other form of inappropriate processing. In the same time quick and easy access to patient information should be granted to authorised personnel to ensure proper and in time treatment of patients. A long lasting sequence of co-operative negotiation meetings between the CMO and the chief information officer (CIO) led to appropriate outline of policies. We developed a suitable and modular architecture for designing systems that can simultaneously manage an increasing number of healthcare actors, objects and related access levels taking into account temporal conditions. Actions for keeping the prototype in use on an everyday basis are directly taken by the CMO.

  14. Leadership Primer for Current and Aspiring Pulmonary, Critical Care, and Sleep Medicine Academic Division Chiefs.

    PubMed

    Nguyen, H Bryant; Thomson, Carey C; Kaminski, Naftali; Schnapp, Lynn M; Madison, J Mark; Glenny, Robb W; Dixon, Anne E

    2018-02-27

    An academic medical career traditionally revolves around patient care, teaching, and scholarly projects. Thus, when an opportunity for a leadership role arises, such as Division Chief, the new leader is often unprepared with little or no formal leadership training. In this article, academic leaders of the Association of Pulmonary, Critical Care and Sleep Division Directors reviewed several leadership concepts adapted from the business sector and applied years of their experience to aid new division chiefs with their first day on the job. The first 90 days are highlighted to include accomplishing the early wins, performing a division Strengths, Weaknesses, Opportunities, and Threats (SWOT) analysis, establishing division rapport, redefining the division infrastructure, avoiding conflicts, and managing their relationship with the department chair. The five levels of leadership applicable to academic medicine are discussed: position, permission, production, people, and pinnacle. Finally, emotional intelligence and behavior styles crucial to leadership success are reviewed.

  15. Leadership Styles of Chief Financial Officers in Higher Education in the Mid-Atlantic Region

    ERIC Educational Resources Information Center

    Benson, Patricia

    2017-01-01

    The purpose of this research was to explore the factors that contribute to a chief financial officer's (CFO) success and demise within a higher education setting. Relatively little attention has been given to the study of leadership in educational institutions (Vroom, 1983). Leadership defines what the future should look like, aligns people with…

  16. The Leadership Orientations of Public College and University Chief Financial Officers: A Frame Analysis

    ERIC Educational Resources Information Center

    Hannah, Charles Russell

    2013-01-01

    The role of the chief financial officer (CFO) is critical to the effective leadership of U.S. four-year public colleges and universities. Self-awareness and the capacity to view situations simultaneously in multiple ways and from different perspectives are essential elements of CFO effectiveness and success in the higher education environment. The…

  17. Facing a "New" Challenge: Chief Student Affairs Officers' Responses to Casino Gambling in Mississippi.

    ERIC Educational Resources Information Center

    Bailey, E. Ann; Dickens, Cynthia S.

    1997-01-01

    Reports on a qualitative study examining chief student affairs officers' (CSAOs) (N=30) perceptions of the impact of legalized casino gambling on student life, service delivery, and student affairs. Results indicate that CSAOs detected few changes in student behavior. Campuses close to casinos reported more dropouts and increases in student debt.…

  18. Creating a Realistic IT Vision: The Roles and Responsibilities of a Chief Information Officer.

    ERIC Educational Resources Information Center

    Penrod, James I.

    2003-01-01

    Discusses the crucial position of the chief information officer (CIO) at higher education institutions and reviews the six major stages of information technology (IT) planning. Includes fundamental elements related to an IT vision; roles of the CIO; the six-stage planning model for a realistic IT vision; and factors for success. (AEF)

  19. Support from Chief Executives to Sponsored Programs Administration at Baccalaureate Universities in the United States

    ERIC Educational Resources Information Center

    Hamilton, Zoya

    2012-01-01

    This research study examined support to sponsored programs administrators (SPAs, or research administrators) at baccalaureate universities from their chief executives. Support to SPAs strengthens the shared purpose of the university, enabling SPAs to serve as effective organizational representatives in business transactions pertaining to grants…

  20. Performance of ’The Star-Spangled Banner,’ Foreign National Anthems, and ’Hail to the Chief’ by Service Bands

    DTIC Science & Technology

    1981-09-18

    traditional musical selection "Hail to the Chief" is designated as a musical tribute to the President of the United States, and may not be per- formed...by military musical organizations as a tribute to other dignitaries. Performances of this selection shall be subject to the following: a. During all...renditions of "Hail to the Chief" by military musical organizations, military personnel in uniform, other than band personnel, shall accord it the same

Some links on this page may take you to non-federal websites. Their policies may differ from this site.