41 CFR 102-117.140 - What is cargo preference?

Code of Federal Regulations, 2013 CFR

2013-07-01

..., Office of Cargo Preference, 1200 New Jersey Ave., SE., Washington, DC 20590, http://marad.dot.gov/. Tel. 1-800-987-3524. E-mail: [email protected]gov. [65 FR 60060, Oct. 6, 2000; 65 FR 81405, Dec. 26, 2000...

41 CFR 102-117.140 - What is cargo preference?

Code of Federal Regulations, 2014 CFR

2014-01-01

..., Office of Cargo Preference, 1200 New Jersey Ave., SE., Washington, DC 20590, http://marad.dot.gov/. Tel. 1-800-987-3524. E-mail: [email protected]gov. [65 FR 60060, Oct. 6, 2000; 65 FR 81405, Dec. 26, 2000...

41 CFR 102-117.140 - What is cargo preference?

Code of Federal Regulations, 2011 CFR

2011-01-01

..., Office of Cargo Preference, 1200 New Jersey Ave., SE., Washington, DC 20590, http://marad.dot.gov/. Tel. 1-800-987-3524. E-mail: [email protected]gov. [65 FR 60060, Oct. 6, 2000; 65 FR 81405, Dec. 26, 2000...

41 CFR 102-117.140 - What is cargo preference?

Code of Federal Regulations, 2012 CFR

2012-01-01

..., Office of Cargo Preference, 1200 New Jersey Ave., SE., Washington, DC 20590, http://marad.dot.gov/. Tel. 1-800-987-3524. E-mail: [email protected]gov. [65 FR 60060, Oct. 6, 2000; 65 FR 81405, Dec. 26, 2000...

seNorge2 daily precipitation, an observational gridded dataset over Norway from 1957 to the present day

NASA Astrophysics Data System (ADS)

Lussana, Cristian; Saloranta, Tuomo; Skaugen, Thomas; Magnusson, Jan; Tveito, Ole Einar; Andersen, Jess

2018-02-01

The conventional climate gridded datasets based on observations only are widely used in atmospheric sciences; our focus in this paper is on climate and hydrology. On the Norwegian mainland, seNorge2 provides high-resolution fields of daily total precipitation for applications requiring long-term datasets at regional or national level, where the challenge is to simulate small-scale processes often taking place in complex terrain. The dataset constitutes a valuable meteorological input for snow and hydrological simulations; it is updated daily and presented on a high-resolution grid (1 km of grid spacing). The climate archive goes back to 1957. The spatial interpolation scheme builds upon classical methods, such as optimal interpolation and successive-correction schemes. An original approach based on (spatial) scale-separation concepts has been implemented which uses geographical coordinates and elevation as complementary information in the interpolation. seNorge2 daily precipitation fields represent local precipitation features at spatial scales of a few kilometers, depending on the station network density. In the surroundings of a station or in dense station areas, the predictions are quite accurate even for intense precipitation. For most of the grid points, the performances are comparable to or better than a state-of-the-art pan-European dataset (E-OBS), because of the higher effective resolution of seNorge2. However, in very data-sparse areas, such as in the mountainous region of southern Norway, seNorge2 underestimates precipitation because it does not make use of enough geographical information to compensate for the lack of observations. The evaluation of seNorge2 as the meteorological forcing for the seNorge snow model and the DDD (Distance Distribution Dynamics) rainfall-runoff model shows that both models have been able to make profitable use of seNorge2, partly because of the automatic calibration procedure they incorporate for precipitation. The seNorge2 dataset 1957-2015 is available at https://doi.org/10.5281/zenodo.845733. Daily updates from 2015 onwards are available at http://thredds.met.no/thredds/catalog/metusers/senorge2/seNorge2/provisional_archive/PREC1d/gridded_dataset/catalog.html.

2016 Guidelines of the American Society of Mammalogists for the use of wild mammals in research and education.

PubMed

Sikes, Robert S

2016-06-09

Guidelines for use of wild mammal species in research are updated from Sikes et al. (2011) . These guidelines cover current professional techniques and regulations involving the use of mammals in research and teaching; they also incorporate new resources, procedural summaries, and reporting requirements. Included are details on capturing, marking, housing, and humanely killing wild mammals. It is recommended that Institutional Animal Care and Use Committees (IACUCs), regulatory agencies, and investigators use these guidelines as a resource for protocols involving wild mammals, whether studied in the field or in captivity. These guidelines were prepared and approved by the American Society of Mammalogists (ASM), in consultation with professional veterinarians experienced in wildlife research and IACUCs, whose collective expertise provides a broad and comprehensive understanding of the biology of nondomesticated mammals. The current version of these guidelines and any subsequent modifications are available online on the Animal Care and Use Committee page of the ASM website ( http://mammalogy.org/uploads/committee_files/CurrentGuidelines.pdf ). Additional resources pertaining to the use of wild animals in research are available at: http://www.mammalsociety.org/committees/animal-care-and-use#tab3 . Los lineamientos para el uso de especies de mamíferos de vida silvestre en la investigación con base en Sikes et al. (2011) se actualizaron. Dichos lineamientos cubren técnicas y regulaciones profesionales actuales que involucran el uso de mamíferos en la investigación y enseñanza; también incorporan recursos nuevos, resúmenes de procedimientos y requisitos para reportes. Se incluyen detalles acerca de captura, marcaje, manutención en cautiverio y eutanasia de mamíferos de vida silvestre. Se recomienda que los comités institucionales de uso y cuidado animal (cifras en inglés: IACUCs), las agencias reguladoras y los investigadores se adhieran a dichos lineamientos como fuente base de protocolos que involucren mamíferos de vida silvestre, ya sea investigaciones de campo o en cautiverio. Dichos lineamientos fueron preparados y aprobados por la ASM, en consulta con profesionales veterinarios experimentados en investigaciones de vida silvestre y IACUCS, de quienes cuya experiencia colectiva provee un entendimiento amplio y exhaustivo de la biología de mamíferos no-domesticados. La presente versión de los lineamientos y modificaciones posteriores están disponibles en línea en la página web de la ASM, bajo Cuidado Animal y Comité de Uso: ( http://mammalogy.org/uploads/committee_files/CurrentGuidelines.pdf ). Recursos adicionales relacionados con el uso de animales de vida silvestre para la investigación se encuentran disponibles en ( http://www.mammalsociety.org/committees/animal-care-and-use#tab3 ).

2016 Guidelines of the American Society of Mammalogists for the use of wild mammals in research and education

PubMed Central

Sikes, Robert S.

2016-01-01

Abstract Guidelines for use of wild mammal species in research are updated from Sikes et al. (2011) . These guidelines cover current professional techniques and regulations involving the use of mammals in research and teaching; they also incorporate new resources, procedural summaries, and reporting requirements. Included are details on capturing, marking, housing, and humanely killing wild mammals. It is recommended that Institutional Animal Care and Use Committees (IACUCs), regulatory agencies, and investigators use these guidelines as a resource for protocols involving wild mammals, whether studied in the field or in captivity. These guidelines were prepared and approved by the American Society of Mammalogists (ASM), in consultation with professional veterinarians experienced in wildlife research and IACUCs, whose collective expertise provides a broad and comprehensive understanding of the biology of nondomesticated mammals. The current version of these guidelines and any subsequent modifications are available online on the Animal Care and Use Committee page of the ASM website ( http://mammalogy.org/uploads/committee_files/CurrentGuidelines.pdf ). Additional resources pertaining to the use of wild animals in research are available at: http://www.mammalsociety.org/committees/animal-care-and-use#tab3 . R esumen Los lineamientos para el uso de especies de mamíferos de vida silvestre en la investigación con base en Sikes et al. (2011) se actualizaron. Dichos lineamientos cubren técnicas y regulaciones profesionales actuales que involucran el uso de mamíferos en la investigación y enseñanza; también incorporan recursos nuevos, resúmenes de procedimientos y requisitos para reportes. Se incluyen detalles acerca de captura, marcaje, manutención en cautiverio y eutanasia de mamíferos de vida silvestre. Se recomienda que los comités institucionales de uso y cuidado animal (cifras en inglés: IACUCs), las agencias reguladoras y los investigadores se adhieran a dichos lineamientos como fuente base de protocolos que involucren mamíferos de vida silvestre, ya sea investigaciones de campo o en cautiverio. Dichos lineamientos fueron preparados y aprobados por la ASM, en consulta con profesionales veterinarios experimentados en investigaciones de vida silvestre y IACUCS, de quienes cuya experiencia colectiva provee un entendimiento amplio y exhaustivo de la biología de mamíferos no-domesticados. La presente versión de los lineamientos y modificaciones posteriores están disponibles en línea en la página web de la ASM, bajo Cuidado Animal y Comité de Uso: ( http://mammalogy.org/uploads/committee_files/CurrentGuidelines.pdf ). Recursos adicionales relacionados con el uso de animales de vida silvestre para la investigación se encuentran disponibles en ( http://www.mammalsociety.org/committees/animal-care-and-use#tab3 ). PMID:29692469

galaxie--CGI scripts for sequence identification through automated phylogenetic analysis.

PubMed

Nilsson, R Henrik; Larsson, Karl-Henrik; Ursing, Björn M

2004-06-12

The prevalent use of similarity searches like BLAST to identify sequences and species implicitly assumes the reference database to be of extensive sequence sampling. This is often not the case, restraining the correctness of the outcome as a basis for sequence identification. Phylogenetic inference outperforms similarity searches in retrieving correct phylogenies and consequently sequence identities, and a project was initiated to design a freely available script package for sequence identification through automated Web-based phylogenetic analysis. Three CGI scripts were designed to facilitate qualified sequence identification from a Web interface. Query sequences are aligned to pre-made alignments or to alignments made by ClustalW with entries retrieved from a BLAST search. The subsequent phylogenetic analysis is based on the PHYLIP package for inferring neighbor-joining and parsimony trees. The scripts are highly configurable. A service installation and a version for local use are found at http://andromeda.botany.gu.se/galaxiewelcome.html and http://galaxie.cgb.ki.se

PON-Sol: prediction of effects of amino acid substitutions on protein solubility.

PubMed

Yang, Yang; Niroula, Abhishek; Shen, Bairong; Vihinen, Mauno

2016-07-01

Solubility is one of the fundamental protein properties. It is of great interest because of its relevance to protein expression. Reduced solubility and protein aggregation are also associated with many diseases. We collected from literature the largest experimentally verified solubility affecting amino acid substitution (AAS) dataset and used it to train a predictor called PON-Sol. The predictor can distinguish both solubility decreasing and increasing variants from those not affecting solubility. PON-Sol has normalized correct prediction ratio of 0.491 on cross-validation and 0.432 for independent test set. The performance of the method was compared both to solubility and aggregation predictors and found to be superior. PON-Sol can be used for the prediction of effects of disease-related substitutions, effects on heterologous recombinant protein expression and enhanced crystallizability. One application is to investigate effects of all possible AASs in a protein to aid protein engineering. PON-Sol is freely available at http://structure.bmc.lu.se/PON-Sol The training and test data are available at http://structure.bmc.lu.se/VariBench/ponsol.php mauno.vihinen@med.lu.se Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Web-Based Cognitive Remediation Improves Supported Employment Outcomes in Severe Mental Illness: Randomized Controlled Trial.

PubMed

Harris, Anthony Wf; Kosic, Tanya; Xu, Jean; Walker, Chris; Gye, William; Redoblado Hodge, Antoinette

2017-09-20

Finding work is a top priority for most people; however, this goal remains out of reach for the majority of individuals with a severe mental illness (SMI) who remain on benefits or are unemployed. Supported employment (SE) programs aimed at returning people with a severe mental illness to work are successful; however, they still leave a significant number of people with severe mental illness unemployed. Cognitive deficits are commonly found in SMI and are a powerful predictor of poor outcome. Fortunately, these deficits are amenable to treatment with cognitive remediation therapy (CRT) that significantly improves cognition in SMI. CRT combined with SE significantly increases the likelihood of individuals with severe mental illness obtaining and staying in work. However, the availability of CRT is limited in many settings. The aim of this study was to examine whether Web-based CRT combined with a SE program can improve the rate return to work of people with severe mental illness. A total of 86 people with severe mental illness (mean age 39.6 years; male: n=55) who were unemployed and who had joined a SE program were randomized to either a Web-based CRT program (CogRem) or an Internet-based control condition (WebInfo). Primary outcome measured was hours worked over 6 months post treatment. At 6 months, those participants randomized to CogRem had worked significantly more hours (P=.01) and had earned significantly more money (P=.03) than those participants randomized to the WebInfo control condition. No change was observed in cognition. This study corroborates other work that has found a synergistic effect of combining CRT with a SE program and extends this to the use of Web-based CRT. The lack of any improvement in cognition obscures the mechanism by which an improved wage outcome for participants randomized to the active treatment was achieved. However, the study substantially lowers the barrier to the deployment of CRT with other psychosocial interventions for severe mental illness. Australian and New Zealand Clinical Trials Registry (ANZCTR) 12611000849998; http://www.anzctr.org.au/TrialSearch.aspx?searchTxt=12611000849998&isBasic=True (Archived by WebCite at http://www.webcitation.org/6sMKwpeos). ©Anthony WF Harris, Tanya Kosic, Jean Xu, Chris Walker, William Gye, Antoinette Redoblado Hodge. Originally published in JMIR Mental Health (http://mental.jmir.org), 20.09.2017.

Research Operations for Advanced Warfighter Interface Technologies

DTIC Science & Technology

2009-06-01

tk.sourceforge.net 11 Available at http://www.speech.kth.se/ snack 17 Cross-word triphone Multi-Space probability Distribution (MSD)-HMMs [23...prepared and delivered for shipment as part of on-going coating evaluations. 6) The IR terrain board was mounted to an extruded aluminum frame for ease of

VerSeDa: vertebrate secretome database

PubMed Central

Cortazar, Ana R.; Oguiza, José A.

2017-01-01

Based on the current tools, de novo secretome (full set of proteins secreted by an organism) prediction is a time consuming bioinformatic task that requires a multifactorial analysis in order to obtain reliable in silico predictions. Hence, to accelerate this process and offer researchers a reliable repository where secretome information can be obtained for vertebrates and model organisms, we have developed VerSeDa (Vertebrate Secretome Database). This freely available database stores information about proteins that are predicted to be secreted through the classical and non-classical mechanisms, for the wide range of vertebrate species deposited at the NCBI, UCSC and ENSEMBL sites. To our knowledge, VerSeDa is the only state-of-the-art database designed to store secretome data from multiple vertebrate genomes, thus, saving an important amount of time spent in the prediction of protein features that can be retrieved from this repository directly. Database URL: VerSeDa is freely available at http://genomics.cicbiogune.es/VerSeDa/index.php PMID:28365718

tRNAscan-SE On-line: integrating search and context for analysis of transfer RNA genes.

PubMed

Lowe, Todd M; Chan, Patricia P

2016-07-08

High-throughput genome sequencing continues to grow the need for rapid, accurate genome annotation and tRNA genes constitute the largest family of essential, ever-present non-coding RNA genes. Newly developed tRNAscan-SE 2.0 has advanced the state-of-the-art methodology in tRNA gene detection and functional prediction, captured by rich new content of the companion Genomic tRNA Database. Previously, web-server tRNA detection was isolated from knowledge of existing tRNAs and their annotation. In this update of the tRNAscan-SE On-line resource, we tie together improvements in tRNA classification with greatly enhanced biological context via dynamically generated links between web server search results, the most relevant genes in the GtRNAdb and interactive, rich genome context provided by UCSC genome browsers. The tRNAscan-SE On-line web server can be accessed at http://trna.ucsc.edu/tRNAscan-SE/. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

VerSeDa: vertebrate secretome database.

PubMed

Cortazar, Ana R; Oguiza, José A; Aransay, Ana M; Lavín, José L

2017-01-01

Based on the current tools, de novo secretome (full set of proteins secreted by an organism) prediction is a time consuming bioinformatic task that requires a multifactorial analysis in order to obtain reliable in silico predictions. Hence, to accelerate this process and offer researchers a reliable repository where secretome information can be obtained for vertebrates and model organisms, we have developed VerSeDa (Vertebrate Secretome Database). This freely available database stores information about proteins that are predicted to be secreted through the classical and non-classical mechanisms, for the wide range of vertebrate species deposited at the NCBI, UCSC and ENSEMBL sites. To our knowledge, VerSeDa is the only state-of-the-art database designed to store secretome data from multiple vertebrate genomes, thus, saving an important amount of time spent in the prediction of protein features that can be retrieved from this repository directly. VerSeDa is freely available at http://genomics.cicbiogune.es/VerSeDa/index.php. © The Author(s) 2017. Published by Oxford University Press.

The Pfam protein families database

PubMed Central

Finn, Robert D.; Mistry, Jaina; Tate, John; Coggill, Penny; Heger, Andreas; Pollington, Joanne E.; Gavin, O. Luke; Gunasekaran, Prasad; Ceric, Goran; Forslund, Kristoffer; Holm, Liisa; Sonnhammer, Erik L. L.; Eddy, Sean R.; Bateman, Alex

2010-01-01

Pfam is a widely used database of protein families and domains. This article describes a set of major updates that we have implemented in the latest release (version 24.0). The most important change is that we now use HMMER3, the latest version of the popular profile hidden Markov model package. This software is ∼100 times faster than HMMER2 and is more sensitive due to the routine use of the forward algorithm. The move to HMMER3 has necessitated numerous changes to Pfam that are described in detail. Pfam release 24.0 contains 11 912 families, of which a large number have been significantly updated during the past two years. Pfam is available via servers in the UK (http://pfam.sanger.ac.uk/), the USA (http://pfam.janelia.org/) and Sweden (http://pfam.sbc.su.se/). PMID:19920124

WebPrInSeS: automated full-length clone sequence identification and verification using high-throughput sequencing data.

PubMed

Massouras, Andreas; Decouttere, Frederik; Hens, Korneel; Deplancke, Bart

2010-07-01

High-throughput sequencing (HTS) is revolutionizing our ability to obtain cheap, fast and reliable sequence information. Many experimental approaches are expected to benefit from the incorporation of such sequencing features in their pipeline. Consequently, software tools that facilitate such an incorporation should be of great interest. In this context, we developed WebPrInSeS, a web server tool allowing automated full-length clone sequence identification and verification using HTS data. WebPrInSeS encompasses two separate software applications. The first is WebPrInSeS-C which performs automated sequence verification of user-defined open-reading frame (ORF) clone libraries. The second is WebPrInSeS-E, which identifies positive hits in cDNA or ORF-based library screening experiments such as yeast one- or two-hybrid assays. Both tools perform de novo assembly using HTS data from any of the three major sequencing platforms. Thus, WebPrInSeS provides a highly integrated, cost-effective and efficient way to sequence-verify or identify clones of interest. WebPrInSeS is available at http://webprinses.epfl.ch/ and is open to all users.

WebPrInSeS: automated full-length clone sequence identification and verification using high-throughput sequencing data

PubMed Central

Massouras, Andreas; Decouttere, Frederik; Hens, Korneel; Deplancke, Bart

2010-01-01

High-throughput sequencing (HTS) is revolutionizing our ability to obtain cheap, fast and reliable sequence information. Many experimental approaches are expected to benefit from the incorporation of such sequencing features in their pipeline. Consequently, software tools that facilitate such an incorporation should be of great interest. In this context, we developed WebPrInSeS, a web server tool allowing automated full-length clone sequence identification and verification using HTS data. WebPrInSeS encompasses two separate software applications. The first is WebPrInSeS-C which performs automated sequence verification of user-defined open-reading frame (ORF) clone libraries. The second is WebPrInSeS-E, which identifies positive hits in cDNA or ORF-based library screening experiments such as yeast one- or two-hybrid assays. Both tools perform de novo assembly using HTS data from any of the three major sequencing platforms. Thus, WebPrInSeS provides a highly integrated, cost-effective and efficient way to sequence-verify or identify clones of interest. WebPrInSeS is available at http://webprinses.epfl.ch/ and is open to all users. PMID:20501601

49 CFR 385.405 - How does a motor carrier apply for a safety permit?

Code of Federal Regulations, 2010 CFR

2010-10-01

..., and instructions for completing the forms, may be obtained on the Internet at http://www.fmcsa.dot.gov, or by contacting FMCSA at Federal Motor Carrier Safety Administration, Office of Information Technology (MC-RI), 1200 New Jersey Ave., SE., Washington, DC 20590-0001, Telephone: 1-800-832-5660. (c...

21 CFR 118.8 - Testing methodology for Salmonella Enteritidis (SE).

Code of Federal Regulations, 2012 CFR

2012-04-01

... Salmonella Web site is located at http://www.fda.gov/Food/ScienceResearch/LaboratoryMethods/ucm114716.htm... Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy., College Park, MD 20740, 301-436-2364, or... Branch Pkwy., College Park, MD, 301-436-2163, or at the National Archives and Records Administration...

75 FR 39629 - Use of One Additional Portable Oxygen Concentrator Device on Board Aircraft

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-12

... in SFAR 106, published July 12, 2005, were the AirSep Corporation's LifeStyle and the Inogen, Inc.'s... devices, AirSep Corporation's FreeStyle, SeQual Technologies' Eclipse, and Respironics Inc.'s EverGo, to... Department of Transportation's Docket Management System. That documentation is available at http://www...

78 FR 33149 - Requested Administrative Waiver of the Coastwise Trade Laws: Vessel CATTITUDE; Invitation for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-03

... Administrative Waiver of the Coastwise Trade Laws: Vessel CATTITUDE; Invitation for Public Comments AGENCY... Floor, Room W12-140, 1200 New Jersey Avenue SE., Washington, DC 20590. You may also send comments electronically via the Internet at http://www.regulations.gov . All comments will become part of this docket and...

Emergent Russia: The Geostrategic Impact

DTIC Science & Technology

2012-05-01

1 1 Historical Trends in Regional Dominance ..................................... 3 2 Post-Cold War Standing...Publishing, 2009), 1 . 2 Bressler, Understanding Contemporary Russia, 1 . 3 Olga Oliker et al., Russian Foreign Policy: Sources and Implications...Putin and edvedev,” Swedish Institute of International Affairs, Occasional Paper, no. 1 , 2010, 3 . http://www.ui.se/upl/files/44020.pdf 4 For analysis

46 CFR 170.015 - Incorporation by reference.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Register under 5 U.S.C. 552(a) and 1 CFR part 51. To enforce any edition other than that specified in this... listed below. (b) American Society for Testing and Materials (ASTM), 100 Barr Harbor Drive, West...), Publications Section, 4 Albert Embankment, London SE1 7SR, United Kingdom, +44 (0)20 7735 7611, http://www.imo...

46 CFR 170.015 - Incorporation by reference.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Register under 5 U.S.C. 552(a) and 1 CFR part 51. To enforce any edition other than that specified in this... listed below. (b) American Society for Testing and Materials (ASTM), 100 Barr Harbor Drive, West...), Publications Section, 4 Albert Embankment, London SE1 7SR, United Kingdom, +44 (0)20 7735 7611, http://www.imo...

46 CFR 170.015 - Incorporation by reference.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Register under 5 U.S.C. 552(a) and 1 CFR part 51. To enforce any edition other than that specified in this...) American Society for Testing and Materials (ASTM), 100 Barr Harbor Drive, West Conshohocken, PA 19428-2959... SE1 7SR, United Kingdom, +44 (0)20 7735 7611, http://www.imo.org/. (1) Resolution MSC.216(82...

46 CFR 170.015 - Incorporation by reference.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Register under 5 U.S.C. 552(a) and 1 CFR part 51. To enforce any edition other than that specified in this...) American Society for Testing and Materials (ASTM), 100 Barr Harbor Drive, West Conshohocken, PA 19428-2959... SE1 7SR, United Kingdom, +44 (0)20 7735 7611, http://www.imo.org/. (1) Resolution MSC.216(82...

jSquid: a Java applet for graphical on-line network exploration.

PubMed

Klammer, Martin; Roopra, Sanjit; Sonnhammer, Erik L L

2008-06-15

jSquid is a graph visualization tool for exploring graphs from protein-protein interaction or functional coupling networks. The tool was designed for the FunCoup web site, but can be used for any similar network exploring purpose. The program offers various visualization and graph manipulation techniques to increase the utility for the user. jSquid is available for direct usage and download at http://jSquid.sbc.su.se including source code under the GPLv3 license, and input examples. It requires Java version 5 or higher to run properly. erik.sonnhammer@sbc.su.se Supplementary data are available at Bioinformatics online.

Acute inhibition of neurosteroid estrogen synthesis suppresses status epilepticus in an animal model

PubMed Central

Sato, Satoru M; Woolley, Catherine S

2016-01-01

Status epilepticus (SE) is a common neurological emergency for which new treatments are needed. In vitro studies suggest a novel approach to controlling seizures in SE: acute inhibition of estrogen synthesis in the brain. Here, we show in rats that systemic administration of an aromatase (estrogen synthase) inhibitor after seizure onset strongly suppresses both electrographic and behavioral seizures induced by kainic acid (KA). We found that KA-induced SE stimulates synthesis of estradiol (E2) in the hippocampus, a brain region commonly involved in seizures and where E2 is known to acutely promote neural activity. Hippocampal E2 levels were higher in rats experiencing more severe seizures. Consistent with a seizure-promoting effect of hippocampal estrogen synthesis, intra-hippocampal aromatase inhibition also suppressed seizures. These results reveal neurosteroid estrogen synthesis as a previously unknown factor in the escalation of seizures and suggest that acute administration of aromatase inhibitors may be an effective treatment for SE. DOI: http://dx.doi.org/10.7554/eLife.12917.001 PMID:27083045

Improving tRNAscan-SE Annotation Results via Ensemble Classifiers.

PubMed

Zou, Quan; Guo, Jiasheng; Ju, Ying; Wu, Meihong; Zeng, Xiangxiang; Hong, Zhiling

2015-11-01

tRNAScan-SE is a tRNA detection program that is widely used for tRNA annotation; however, the false positive rate of tRNAScan-SE is unacceptable for large sequences. Here, we used a machine learning method to try to improve the tRNAScan-SE results. A new predictor, tRNA-Predict, was designed. We obtained real and pseudo-tRNA sequences as training data sets using tRNAScan-SE and constructed three different tRNA feature sets. We then set up an ensemble classifier, LibMutil, to predict tRNAs from the training data. The positive data set of 623 tRNA sequences was obtained from tRNAdb 2009 and the negative data set was the false positive tRNAs predicted by tRNAscan-SE. Our in silico experiments revealed a prediction accuracy rate of 95.1 % for tRNA-Predict using 10-fold cross-validation. tRNA-Predict was developed to distinguish functional tRNAs from pseudo-tRNAs rather than to predict tRNAs from a genome-wide scan. However, tRNA-Predict can work with the output of tRNAscan-SE, which is a genome-wide scanning method, to improve the tRNAscan-SE annotation results. The tRNA-Predict web server is accessible at http://datamining.xmu.edu.cn/∼gjs/tRNA-Predict. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Submersible Aircraft Concept Design Study - Amendment 1. Additional Assessment of Design Risks & Sensitivities within the Original Study, and an Initial Assessment of Key Control Aspects

DTIC Science & Technology

2011-02-01

http://www.redhammer.se/tornado/index.html (3) Aircraft Design: A Conceptual Approach, Daniel P. Raymer , AIAA, 1992 (4) (5) Moran, J., Computational...Fluid Dynamics, Wiley & Sons, 1984. Notes on the Stability and Control of Tailless Airplanes, Robert T. Jones, NACA Technical Note No.837, December

CytoSEED: a Cytoscape plugin for viewing, manipulating and analyzing metabolic models created by the Model SEED

PubMed Central

DeJongh, Matthew; Bockstege, Benjamin; Frybarger, Paul; Hazekamp, Nicholas; Kammeraad, Joshua; McGeehan, Travis

2012-01-01

Summary: CytoSEED is a Cytoscape plugin for viewing, manipulating and analyzing metabolic models created using the Model SEED. The CytoSEED plugin enables users of the Model SEED to create informative visualizations of the reaction networks generated for their organisms of interest. These visualizations are useful for understanding organism-specific biochemistry and for highlighting the results of flux variability analysis experiments. Availability and Implementation: Freely available for download on the web at http://sourceforge.net/projects/cytoseed/. Implemented in Java SE 6 and supported on all platforms that support Cytoscape. Contact: dejongh@hope.edu Supplementary information: Installation instructions, a tutorial, and full-size figures are available at http://www.cs.hope.edu/cytoseed/. PMID:22210867

Using online database for landslide susceptibility assessment with an example from the Veneto Region (north-eastern Italy).

NASA Astrophysics Data System (ADS)

Floris, Mario; Squarzoni, Cristina; Zorzi, Luca; D'Alpaos, Andrea; Iafelice, Maria

2010-05-01

Landslide susceptibility maps describe landslide-prone areas by the spatial correlation between landslides and related factors, derived from different kinds of datasets: geological, geotechnical and geomechanical maps, hydrogeological maps, landslides maps, vector and raster terrain data, real-time inclinometer and pore pressure data. In the last decade, thanks to the increasing use of web-based tools for management, sharing and communication of territorial information, many Web-based Geographical Information Systems (WebGIS) were created by local governments or nations, University and Research Centres. Nowadays there is a strong proliferation of geological WebGIS or GeoBrowser, allowing free download of spatial information. There are global Cartographical Portals that provide a free download of DTM and other vector data related to the whole planet (http://www.webgis.com). At major scale, there are WebGIS regarding entire nation (http://www.agiweb.org), or specific region of a country (http://www.mrt.tas.gov.au), or single municipality (http://sitn.ne.ch/). Moreover, portals managed by local government and academic government (http://turtle.ags.gov.ab.ca/Peace_River/Site/) or by a private agency (http://www.bbt-se.com) are noteworthy. In Italy, the first national projects for the creation of WebGIS and web-based databases begun during the 1980s, and evolved, through years, to the present number of different WebGIS, which have different territorial extensions: national (Italian National Cartographical Portal, http://www.pcn.minambiente.it; E-GEO Project, http://www.egeo.unisi.it), interregional (River Tiber Basin Authority, www.abtevere.it ), and regional (Veneto Region, www.regione.veneto.it). In this way we investigated most of the Italian WebGIS in order to verify their geographic range and the availability and quality of data useful for landslide hazard analyses. We noticed a large variability of the accessing information among the different browsers. In particular, the Trento and Bolzano Provinces Geobrowsers (http://www.provincia.bz.it; http://www.territorio.provincia.tn.it) provide a large availability of data respect to the other regional and interregional WebGIS, which generally allow only the download of topographic data. Recently, the Italian Institute for Environmental Protection and Research, ISPRA (Istituto Superiore per la Protezione e la ricerca Ambientale), makes available and free usable the Italian Inventory of Landslides (IFFI Project). The inventory contains information derived from the census of all the instability phenomena in Italy, offering a base-cognitive instrument for the landslide hazard evaluation. For the landslide hazard assessment it is essential to evaluate the real effectiveness of the available data. Hence, we test the effectiveness of the web databases to evaluate the landslides susceptibility in the Euganean Hill Regional Park (185.5 km2), located at SE of Padua (Veneto Region, Italy). We used data available from three online spatial databases: Veneto Region Cartographic Portal (http://www.regione.veneto.it), for vector terrain data at 1:5000 scale; the IFFI archive (http://www.sinanet.apat.it), for information concerning landslides; and the National Cartographic Portal of the Italian Ministry of Environment (http://www.pcn.minambiente.it), for the multi-temporal orthophotos. The landslide susceptibility was evaluated using a simple probabilistic analysis considering the relationships between landslides and DEM-derived factors, such as slope, curvature and aspect. For the validation of the analysis, we made a spatial test by subdividing the study area in two sectors: training area and test area. The obtained results show that the actual no-completeness of online available spatial databases related to the Veneto Region allows only regional and medium scale (>1:25,000) susceptibility analysis. Data about lithology, land use, groundwater and others relevant factors are absent. In addition, the lack of data on the temporal evolution of the landslides permits only a spatial analysis, impeding a complete evaluation of the landslide hazard.

The Northern Circumpolar Soil Carbon Database: spatially distributed datasets of soil coverage and soil carbon storage in the northern permafrost regions

NASA Astrophysics Data System (ADS)

Hugelius, G.; Tarnocai, C.; Broll, G.; Canadell, J. G.; Kuhry, P.; Swanson, D. K.

2012-08-01

High latitude terrestrial ecosystems are key components in the global carbon (C) cycle. Estimates of global soil organic carbon (SOC), however, do not include updated estimates of SOC storage in permafrost-affected soils or representation of the unique pedogenic processes that affect these soils. The Northern Circumpolar Soil Carbon Database (NCSCD) was developed to quantify the SOC stocks in the circumpolar permafrost region (18.7 × 106 km2). The NCSCD is a polygon-based digital database compiled from harmonized regional soil classification maps in which data on soil order coverage has been linked to pedon data (n = 1647) from the northern permafrost regions to calculate SOC content and mass. In addition, new gridded datasets at different spatial resolutions have been generated to facilitate research applications using the NCSCD (standard raster formats for use in Geographic Information Systems and Network Common Data Form files common for applications in numerical models). This paper describes the compilation of the NCSCD spatial framework, the soil sampling and soil analyses procedures used to derive SOC content in pedons from North America and Eurasia and the formatting of the digital files that are available online. The potential applications and limitations of the NCSCD in spatial analyses are also discussed. The database has the doi:10.5879/ecds/00000001. An open access data-portal with all the described GIS-datasets is available online at: http://dev1.geo.su.se/bbcc/dev/ncscd/.

The Northern Circumpolar Soil Carbon Database: spatially distributed datasets of soil coverage and soil carbon storage in the northern permafrost regions

NASA Astrophysics Data System (ADS)

Hugelius, G.; Tarnocai, C.; Broll, G.; Canadell, J. G.; Kuhry, P.; Swanson, D. K.

2013-01-01

High-latitude terrestrial ecosystems are key components in the global carbon (C) cycle. Estimates of global soil organic carbon (SOC), however, do not include updated estimates of SOC storage in permafrost-affected soils or representation of the unique pedogenic processes that affect these soils. The Northern Circumpolar Soil Carbon Database (NCSCD) was developed to quantify the SOC stocks in the circumpolar permafrost region (18.7 × 106 km2). The NCSCD is a polygon-based digital database compiled from harmonized regional soil classification maps in which data on soil order coverage have been linked to pedon data (n = 1778) from the northern permafrost regions to calculate SOC content and mass. In addition, new gridded datasets at different spatial resolutions have been generated to facilitate research applications using the NCSCD (standard raster formats for use in geographic information systems and Network Common Data Form files common for applications in numerical models). This paper describes the compilation of the NCSCD spatial framework, the soil sampling and soil analytical procedures used to derive SOC content in pedons from North America and Eurasia and the formatting of the digital files that are available online. The potential applications and limitations of the NCSCD in spatial analyses are also discussed. The database has the doi:10.5879/ecds/00000001. An open access data portal with all the described GIS-datasets is available online at: http://www.bbcc.su.se/data/ncscd/.

Air and Space Power Journal (ASPJ). Volume 25, Number 1

DTIC Science & Technology

2011-01-01

gators who began their careers at US military R&D centers supervised the development of licensed vaccines for yellow fever, mumps, measles, varicella ...of the 27th Special Operations Medical Group, Cannon AFB, New Mexico . Colonel Hall has supported numerous combat operations, including Iraqi Freedom... Mexico Press (http://www.unmpress.com), 1312 Basehart Road SE, Albuquerque, New Mexico 87106-4363, 2009, 485 pages, $44.00 (hardcover), ISBN 978-0

The William Perry Center for Hemispheric Defense Studies (The Perry Center)

Science.gov Websites

de usuario multilingüe para sus visitantes, y consolidará el contenido que solía extenderse a sites. * * * 21 septiembre, 2017 El Centro William J. Perry se complace en anunciar su nuevo hogar virtual. La nueva página, ubicada en [http://williamjperrycenter.org], ofrece una verdadera experiencia

Web site access statistics and delivery of research results

Treesearch

Daniel L. Schmoldt; Matthew F. Winn; Philip A. Araman

1998-01-01

For the past 2-1/2 years, our Research Work Unit (RWU) has been operating a Web site (http://www.se4702.forprod.vt.edu). The site became operational in October 1995. In the beginning, it was primarily designed to stake out a piece of the Internet with our name and our RWU’s organizational mission. Quickly, it became apparent to us, however, that our user community...

Designing clinically useful systems: examples from medicine and dentistry.

PubMed

Koch, S

2003-12-01

Despite promising results in medical informatics research and the development of a large number of different systems, few systems get beyond a prototype state and are really used in practice. Among other factors, the lack of explicit user focus is one main reason. The research projects presented in this paper follow a user-centered system development approach based on extensive work analyses in interdisciplinary working groups, taking into account human cognitive performance. Different medical and health-care specialists, together with researchers in human-computer interaction and medical informatics, specify future clinical work scenarios. Special focus is put on analysis and design of the information and communication flow and on exploration of intuitive visualization and interaction techniques for clinical information. Adequate choice of the technical access device is made depending on the user's work situation. It is the purpose of this paper to apply this method in two different research projects and thereby to show its potential for designing clinically useful systems that do support and not hamper clinical work. These research projects cover IT support for chairside work in dentistry (http://www.dis.uu.se/mdi/research/projects/orquest) and ICT support for home health care of elderly citizens (http://www.medsci.uu.se/mie/project/closecare).

Effects of Pressure on Optically Active Deep Levels in Phosphorus Doped ZnSe

NASA Astrophysics Data System (ADS)

Weinstein, B. A.; Iota, V.

1998-03-01

We report high pressure photoluminescence (PL) and PL-excitation (PLE) studies at 8K of the 'midgap' emission in P-doped ZnSe using a diamond-cell with He medium. The dominant emission at low pressure is due to donor-acceptor-pair (DAP) transitions between shallow donors and deep trigonally relaxed P_Se acceptors.(J. Davies, et al., J. Luminescence 18/19, 322 (1979)) Its PL and PLE peaks shift by 8.2meV/kbar and 5.9meV/kbar, respectively -- Stokes shift decreasing with pressure. At 35kbar a new PL band, shifting to lower energy (-5.4meV/kbar), emerges from above the absorption edge, and concurrently the original DAP PL quenches. This shows that a resonant level, a deep donor or possibly a P_Se antibonding state,(R. Watts, et al., Phys. Rev. B3), 404 (1971) crosses the conduction edge into the gap. A third PL band is seen only with internse UV excitation. It occurs initially as a high energy shoulder of the original DAP peak, but shifts more rapidly upward (9.4meV/kbar) until it crosses the edge and quenches at 40kbar. We discuss candidates for this band, including donor-P_Se complexes, and we compare our results to similar work on the Zn vacancy in ZnSe. (figures)

Civitas: Toward a Secure Voting System

DTIC Science & Technology

2008-05-01

voting, we believe that remote vot- ing is the right problem to solve. One of our goals was therefore to strike a reasonable compromise between enabling...versions of this work. References [1] Ben Adida . Advances in Cryptographic Voting Systems. PhD thesis, MIT, Aug. 2006. [2] Roberto Araújo, Sébastien...3] Association for Computing Machinery. SIG elections. http://www.acm.org/sigs/elections, 2007. [4] Jonathan Bannet, David W. Price , Algis Rudys

Islamist Terrorist Networks in Bosnia and Herzegovina

DTIC Science & Technology

2009-09-01

for citizens to participate in politics and political processes, education, medical and health care systems, physical and communications...Are Changes in Bosnia Real or Rhetorical?” The Washington Report on Middle East Affairs 25, no. 1 (January 1, 2006): 38–39. 98 Goran Vezic and Zana ...1, 2006). 86 Vezic, Goran and Zana Kovacevic. “Ante Jelavic za RSE-Necu se vracati u BiH.” Slobodnaeuropa.org. July 19, 2006. http

The Malacca Dilemma - Countering China’s String of Pearls with Land-Based Airpower

DTIC Science & Technology

2006-06-01

30 Linus Hagström and Johan Lagerkvist, “Sino-Japanese cold war,” Axess Magazine, vol. 1, 2005, http://www.axess.se/english/2005/01...ways carrier aviation cannot. General Paul Hester, Commander of the Pacific Air Forces, observed, “The capability for airmen to rapidly respond...land-based airpower in the Pacific, Generals Paul Hester and David Deptula were instrumental in setting up RESULTANT FURY, a PACOM exercise

Creating a Library of Climate Change Education Resources for Audiences in the Southeast United States

NASA Astrophysics Data System (ADS)

Carroll, J.; McNeal, K. S.; Williams, C. C.; Paz, J. O.; Cho, H. "; Nair, U. S.; Geroux, J.; Guthrie, C.; Wright, K.; Hill, J.

2011-12-01

The Climate Literacy Partnership in the Southeast (CLiPSE) is a part of the Climate Change Education Program supported by the National Science Foundation (http://CLiPSE-project.org). The established CLiPSE partnership is dedicated to improving climate literacy in the southeast and promoting scientifically accurate, formal educational resources for the K-12 classroom audience, as well as informal educational resources for audiences such as agriculture, education, leisure, and religious organizations, to name a few. The CLiPSE project has been successful in creating partnerships with the National Geographic Alliances, Departments of Education, and Mississippi Environmental Education Alliance, among others, to determine an effective strategic plan for reaching K-12 audiences. One goal in the strategic plan is to create a catalog of climate change education resources that are aligned to state standards in the SE. Eighty-seven resources from the Climate Literacy and Energy Awareness Network (http://cleanet.org) have been aligned with the state education standards for grades six through twelve in the southeast, beginning with science in Mississippi and expanding to include science and math in the remaining SE states. The criteria for aligning the existing resources includes: matching key terms, topics, and lesson activities with the content strands and essential skills included in the state science framework. By developing a searchable database containing climate resources already aligned with state standards, CLiPSE will have made these resources more appealing to educators in the SE, increasing the likelihood of resources being implemented in the classroom. The CLiPSE Climate Science Team has also created an inventory of scientifically sound, informal resources, which will be available for dispersion to appropriate audiences and communities. Cataloged resources, both formal and informal, grouped by a variety of means, to include audience, grade level, and resource origin (e.g. government agency, organization, museum, climate-related websites, etc.), will be made available to the public through the CLiPSE website, promoting accessibility of these resources to the various CLiPSE publics. The process of alignment and vetting will be discussed in this paper, along with the information and education "gaps" that exist for the specific CLiPSE audiences in the SE US.

Selenium extraction: development on extraction chromatographic resins compatible with Diffusive Gradient in Thin film (DGT)

NASA Astrophysics Data System (ADS)

Rad, S.; Dirks-Fandrei, C.; Happel, S. A.; Bombard, A.; Cary, L.

2016-12-01

Measurement of Selenium is of importance regarding public health as the ratio between beneficial daily intake and toxicity is rather low [1], [2]. Also from the radiological perspective, Se-79 as a long-lived fission nuclide (T1/2=2.8x105y) with high mobility in environment, is of concern regarding waste management and decommissioning [3], [4]. Due to the existence of different oxidation states Selenium has a complex speciation chemistry which makes extraction and separation schemes not straightforward. The aim of this research is to develop extraction methods for Selenium based on extraction chromatographic resins allowing for the extraction of Se(VI), as well as Se(IV), from water samples for later use on DGT (Diffusive Gradients in Thin films) devices. Extraction chromatographic resins have been tested and characterized for Se and other elements. For Se(VI) a commercially available Aliquat 336 based extraction chromatographic resin (TEVA resin[5]) was found to be most suitable, for Se(IV) a newly developed extraction chromatographic resin based on Piazselenol chemistry was found to be most effective, data on the selectivity of this resin will be presented. The extraction of Se(IV) and Se(VI) by these resins was tested on water sampled in Lille City, where a high Se spatial variability has been observed. Concentrations in groundwater can reach 30µg/L as a consequence; most Se-contaminated wells are no longer exploited by the water operators. One of the applications of this development is to be able to measure Se concentrations insitu in contaminated areas including very complex object such as hyporheic zone. [1] Cary L. et al. Applied Geochemistry 48 (2014) 70-82 [2] Chen C. et al. Biological Trace Element Research Vols. 71-72 (1999) 131-138 [3] http://www.irsn.fr/FR/Larecherche/publications-documentation/fiches-radionucleides/Documents/environnement/Selenium_Se79_v2.pdf last access 03/03/2016 [4] Uchida et al. WM2009 Conference, March 1-5, 2009, Phoenix, AZ [5] Horwitz P. et al. Analytica Chimica Acta 310 (1995) 63-78

The Pfam protein families database.

PubMed

Punta, Marco; Coggill, Penny C; Eberhardt, Ruth Y; Mistry, Jaina; Tate, John; Boursnell, Chris; Pang, Ningze; Forslund, Kristoffer; Ceric, Goran; Clements, Jody; Heger, Andreas; Holm, Liisa; Sonnhammer, Erik L L; Eddy, Sean R; Bateman, Alex; Finn, Robert D

2012-01-01

Pfam is a widely used database of protein families, currently containing more than 13,000 manually curated protein families as of release 26.0. Pfam is available via servers in the UK (http://pfam.sanger.ac.uk/), the USA (http://pfam.janelia.org/) and Sweden (http://pfam.sbc.su.se/). Here, we report on changes that have occurred since our 2010 NAR paper (release 24.0). Over the last 2 years, we have generated 1840 new families and increased coverage of the UniProt Knowledgebase (UniProtKB) to nearly 80%. Notably, we have taken the step of opening up the annotation of our families to the Wikipedia community, by linking Pfam families to relevant Wikipedia pages and encouraging the Pfam and Wikipedia communities to improve and expand those pages. We continue to improve the Pfam website and add new visualizations, such as the 'sunburst' representation of taxonomic distribution of families. In this work we additionally address two topics that will be of particular interest to the Pfam community. First, we explain the definition and use of family-specific, manually curated gathering thresholds. Second, we discuss some of the features of domains of unknown function (also known as DUFs), which constitute a rapidly growing class of families within Pfam.

RatMap--rat genome tools and data.

PubMed

Petersen, Greta; Johnson, Per; Andersson, Lars; Klinga-Levan, Karin; Gómez-Fabre, Pedro M; Ståhl, Fredrik

2005-01-01

The rat genome database RatMap (http://ratmap.org or http://ratmap.gen.gu.se) has been one of the main resources for rat genome information since 1994. The database is maintained by CMB-Genetics at Goteborg University in Sweden and provides information on rat genes, polymorphic rat DNA-markers and rat quantitative trait loci (QTLs), all curated at RatMap. The database is under the supervision of the Rat Gene and Nomenclature Committee (RGNC); thus much attention is paid to rat gene nomenclature. RatMap presents information on rat idiograms, karyotypes and provides a unified presentation of the rat genome sequence and integrated rat linkage maps. A set of tools is also available to facilitate the identification and characterization of rat QTLs, as well as the estimation of exon/intron number and sizes in individual rat genes. Furthermore, comparative gene maps of rat in regard to mouse and human are provided.

RatMap—rat genome tools and data

PubMed Central

Petersen, Greta; Johnson, Per; Andersson, Lars; Klinga-Levan, Karin; Gómez-Fabre, Pedro M.; Ståhl, Fredrik

2005-01-01

The rat genome database RatMap (http://ratmap.org or http://ratmap.gen.gu.se) has been one of the main resources for rat genome information since 1994. The database is maintained by CMB–Genetics at Göteborg University in Sweden and provides information on rat genes, polymorphic rat DNA-markers and rat quantitative trait loci (QTLs), all curated at RatMap. The database is under the supervision of the Rat Gene and Nomenclature Committee (RGNC); thus much attention is paid to rat gene nomenclature. RatMap presents information on rat idiograms, karyotypes and provides a unified presentation of the rat genome sequence and integrated rat linkage maps. A set of tools is also available to facilitate the identification and characterization of rat QTLs, as well as the estimation of exon/intron number and sizes in individual rat genes. Furthermore, comparative gene maps of rat in regard to mouse and human are provided. PMID:15608244

THOR contribution to space weather science

NASA Astrophysics Data System (ADS)

Vaivads, A.; Opgenoorth, H. J.; Retino, A.; Khotyaintsev, Y. V.; Soucek, J.; Valentini, F.; Escoubet, C. P.; Chen, C. H. K.; Vainio, R. O.; Fazakerley, A. N.; Lavraud, B.; Narita, Y.; Marcucci, M. F.; Kucharek, H.; Bale, S. D.; Moore, T. E.; Kistler, L. M.; Samara, M.

2016-12-01

Turbulence Heating ObserveR - THOR is a mission proposal to study energy dissipation and particle acceleration in turbulent space plasma. THOR will focus on turbulent plasma in pristine solar wind, bow shock and magnetosheath. The orbit of THOR is tuned to spend long times in those regions allowing THOR to obtain high resolution data sets that can be used also for space weather science. Here we will discuss the space weather science questions that can be addressed and significantly advanced using THOR. Link to THOR: http://thor.irfu.se.

SeMPI: a genome-based secondary metabolite prediction and identification web server.

PubMed

Zierep, Paul F; Padilla, Natàlia; Yonchev, Dimitar G; Telukunta, Kiran K; Klementz, Dennis; Günther, Stefan

2017-07-03

The secondary metabolism of bacteria, fungi and plants yields a vast number of bioactive substances. The constantly increasing amount of published genomic data provides the opportunity for an efficient identification of gene clusters by genome mining. Conversely, for many natural products with resolved structures, the encoding gene clusters have not been identified yet. Even though genome mining tools have become significantly more efficient in the identification of biosynthetic gene clusters, structural elucidation of the actual secondary metabolite is still challenging, especially due to as yet unpredictable post-modifications. Here, we introduce SeMPI, a web server providing a prediction and identification pipeline for natural products synthesized by polyketide synthases of type I modular. In order to limit the possible structures of PKS products and to include putative tailoring reactions, a structural comparison with annotated natural products was introduced. Furthermore, a benchmark was designed based on 40 gene clusters with annotated PKS products. The web server of the pipeline (SeMPI) is freely available at: http://www.pharmaceutical-bioinformatics.de/sempi. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

The orbifolder: A tool to study the low-energy effective theory of heterotic orbifolds

NASA Astrophysics Data System (ADS)

Nilles, H. P.; Ramos-Sánchez, S.; Vaudrevange, P. K. S.; Wingerter, A.

2012-06-01

The orbifolder is a program developed in C++ that computes and analyzes the low-energy effective theory of heterotic orbifold compactifications. The program includes routines to compute the massless spectrum, to identify the allowed couplings in the superpotential, to automatically generate large sets of orbifold models, to identify phenomenologically interesting models (e.g. MSSM-like models) and to analyze their vacuum configurations. Program summaryProgram title: orbifolder Catalogue identifier: AELR_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AELR_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU General Public License version 3 No. of lines in distributed program, including test data, etc.: 145 572 No. of bytes in distributed program, including test data, etc.: 930 517 Distribution format: tar.gz Programming language:C++ Computer: Personal computer Operating system: Tested on Linux (Fedora 15, Ubuntu 11, SuSE 11) Word size: 32 bits or 64 bits Classification: 11.1 External routines: Boost (http://www.boost.org/), GSL (http://www.gnu.org/software/gsl/) Nature of problem: Calculating the low-energy spectrum of heterotic orbifold compactifications. Solution method: Quadratic equations on a lattice; representation theory; polynomial algebra. Running time: Less than a second per model.

The Pfam protein families database

PubMed Central

Punta, Marco; Coggill, Penny C.; Eberhardt, Ruth Y.; Mistry, Jaina; Tate, John; Boursnell, Chris; Pang, Ningze; Forslund, Kristoffer; Ceric, Goran; Clements, Jody; Heger, Andreas; Holm, Liisa; Sonnhammer, Erik L. L.; Eddy, Sean R.; Bateman, Alex; Finn, Robert D.

2012-01-01

Pfam is a widely used database of protein families, currently containing more than 13 000 manually curated protein families as of release 26.0. Pfam is available via servers in the UK (http://pfam.sanger.ac.uk/), the USA (http://pfam.janelia.org/) and Sweden (http://pfam.sbc.su.se/). Here, we report on changes that have occurred since our 2010 NAR paper (release 24.0). Over the last 2 years, we have generated 1840 new families and increased coverage of the UniProt Knowledgebase (UniProtKB) to nearly 80%. Notably, we have taken the step of opening up the annotation of our families to the Wikipedia community, by linking Pfam families to relevant Wikipedia pages and encouraging the Pfam and Wikipedia communities to improve and expand those pages. We continue to improve the Pfam website and add new visualizations, such as the ‘sunburst’ representation of taxonomic distribution of families. In this work we additionally address two topics that will be of particular interest to the Pfam community. First, we explain the definition and use of family-specific, manually curated gathering thresholds. Second, we discuss some of the features of domains of unknown function (also known as DUFs), which constitute a rapidly growing class of families within Pfam. PMID:22127870

An online spaced-education game among clinicians improves their patients' time to blood pressure control: a randomized controlled trial.

PubMed

Kerfoot, B Price; Turchin, Alexander; Breydo, Eugene; Gagnon, David; Conlin, Paul R

2014-05-01

Many patients with high blood pressure (BP) do not have antihypertensive medications appropriately intensified at clinician visits. We investigated whether an online spaced-education (SE) game among primary care clinicians can decrease time to BP target among their hypertensive patients. A 2-arm randomized trial was conducted over 52 weeks among primary care clinicians at 8 hospitals. Educational content consisted of 32 validated multiple-choice questions with explanations on hypertension management. Providers were randomized into 2 groups: SE clinicians were enrolled in the game, whereas control clinicians received identical educational content in an online posting. SE game clinicians were e-mailed 1 question every 3 days. Adaptive game mechanics resent questions in 12 or 24 days if answered incorrectly or correctly, respectively. Clinicians retired questions by answering each correctly twice consecutively. Posting of relative performance among peers fostered competition. Primary outcome measure was time to BP target (<140/90 mm Hg). One hundred eleven clinicians enrolled. The SE game was completed by 87% of clinicians (48/55), whereas 84% of control clinicians (47/56) read the online posting. In multivariable analysis of 17 866 hypertensive periods among 14 336 patients, the hazard ratio for time to BP target in the SE game cohort was 1.043 (95% confidence interval, 1.007-1.081; P=0.018). The number of hypertensive episodes needed to treat to normalize one additional patient's BP was 67.8. The number of clinicians needed to teach to achieve this was 0.43. An online SE game among clinicians generated a modest but significant reduction in the time to BP target among their hypertensive patients. http://www.clinicaltrials.gov. Unique identifier: NCT00904007. © 2014 American Heart Association, Inc.

Simulated single molecule microscopy with SMeagol.

PubMed

Lindén, Martin; Ćurić, Vladimir; Boucharin, Alexis; Fange, David; Elf, Johan

2016-08-01

SMeagol is a software tool to simulate highly realistic microscopy data based on spatial systems biology models, in order to facilitate development, validation and optimization of advanced analysis methods for live cell single molecule microscopy data. SMeagol runs on Matlab R2014 and later, and uses compiled binaries in C for reaction-diffusion simulations. Documentation, source code and binaries for Mac OS, Windows and Ubuntu Linux can be downloaded from http://smeagol.sourceforge.net johan.elf@icm.uu.se Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press.

Survey on workforce retention and attrition

NASA Astrophysics Data System (ADS)

Showstack, Randy

2013-03-01

The Society of Petroleum Engineers (SPE) is conducting a survey to gather information on why technical professionals change jobs or quit working. The survey, prompted by concern about the retention of skilled workers, aims to provide information to employers that can assist them in addressing practices that can lead to significant workforce attrition. To participate in the survey, which is open to everyone (including those who are not SPE members), go to http://research.spe.org/se.ashx?s=705E3F1335720258 through 15 May 2013. For more information, contact speresearch@spe.org.

A Video Game Promoting Cancer Risk Perception and Information Seeking Behavior Among Young-Adult College Students: A Randomized Controlled Trial.

PubMed

Khalil, Georges Elias; Beale, Ivan L; Chen, Minxing; Prokhorov, Alexander V

2016-07-28

Risky behaviors tend to increase drastically during the transition into young adulthood. This increase may ultimately facilitate the initiation of carcinogenic processes at a young age, highlighting a serious public health problem. By promoting information seeking behavior (ISB), young adults may become aware of cancer risks and potentially take preventive measures. Based on the protection motivation theory, the current study seeks to evaluate the impact of challenge in a fully automated video game called Re-Mission on young adult college students' tendency to perceive the severity of cancer, feel susceptible to cancer, and engage in ISB. A total of 216 young adults were recruited from a university campus, consented, screened, and randomized in a single-blinded format to 1 of 3 conditions: an intervention group playing Re-Mission at high challenge (HC; n=85), an intervention group playing Re-Mission at low challenge (LC; n=81), and a control group with no challenge (NC; presented with illustrated pictures of Re-Mission; n=50). Measurement was conducted at baseline, immediate posttest, 10-day follow-up, and 20-day follow-up. Repeated-measures mixed-effect models were conducted for data analysis of the main outcomes. A total of 101 young adults continued until 20-day follow-up. Mixed-effect models showed that participants in the HC and LC groups were more likely to increase in perceived susceptibility to cancer (P=.03), perceived severity of cancer (P=.02), and ISB (P=.01) than participants in the NC group. The LC group took until 10-day follow-up to show increase in perceived susceptibility (B=0.47, standard error (SE) 0.16, P=.005). The HC group showed an immediate increase in perceived susceptibility at posttest (B=0.43, SE 0.14, P=.002). The LC group exhibited no changes in perceived severity (B=0.40, SE 0.33, P=.24). On the other hand, the HC group showed a significant increase from baseline to posttest (B=0.39, SE 0.14, P=.005), maintaining this increase until 20-day follow-up (B=-0.007, SE 0.26, P=.98). Further analyses indicated that perceived threat from virtual cancer cells in the game is related to the increase in perceived severity (B=0.1, SE 0.03, P=.001), and perceived susceptibility is related to changes in ISB at 10-day follow-up (B=0.21, SE 0.08, P=.008). The feature of challenge with cancer cells in a virtual environment has the potential to increase cancer risk perception and ISB. The results are promising considering that the Re-Mission intervention was neither designed for cancer risk communication, nor applied among healthy individuals. Further research is needed to understand the theoretical framework underlying the effects of Re-Mission on ISB. The findings call for the development of a Web-based, game-based intervention for cancer risk communication and information seeking among young adults. International Standard Randomized Controlled Trial Number (ISRCTN): 15789289; http://www.controlled-trials.com/ISRCTN15789289 (Archived by WebCite at http://www.webcitation.org/6jGYZC3lZ).

Leadership behaviours and healthcare research performance: prospective correlational study.

PubMed

Patel, Vanash M; Ashrafian, Hutan; Uzoho, Chukwudi; Nikiteas, Nikolaos; Panzarasa, Pietro; Sevdalis, Nick; Darzi, Ara; Athanasiou, Thanos

2016-05-16

The aims of the study were to determine whether differences in leadership self-perception/behaviour in healthcare researchers may influence research performance and to evaluate whether certain leadership characteristics are associated with enhanced leadership efficiency in terms of motivation, effectiveness and satisfaction. All Faculty of Medicine Professors at Imperial College London (n=215) were sent the Multifactor Leadership Questionnaire (MLQ) Self form as a means of evaluating self-perception of leadership behaviours. For each professor, we extracted objective research performance measures (total number of publications, total number of citations and h index) from 1 January 2007 to 31 December 2009. The MLQ measured three leadership outcomes, which included motivation, effectiveness and satisfaction. Regression analysis was used to determine associations. A total number of 90 responses were received, which equated to a 42% response rate. There were no significant correlations between transformational, transactional or passive/avoidant leadership behaviours and any of the research performance measures. The five transformational leadership behaviours (ie, idealised attributes (IA), idealised behaviours (IB), inspirational motivation (IM), intellectual stimulation (IS), individual consideration (IC)) were highly significant predictors of leadership outcomes, extra effort (all B>0.404, SE=0.093-0.146, p<0.001), effectiveness (IA, IM, IS, IC B>0.359, SE=0.093-0.146, p<0.001; IB B=0.233, SE=0.103, p=0.026) and satisfaction (IA, IM, IS, IC B>0.483, SE=0.086-0.139, p<0.001; IB B=0.296, SE=0.101, p=0.004). Similarly, contingent reward was a significant predictor of extra effort (B=0.400, SE=0.123, p=0.002), effectiveness (B=0.353, SE=0.113, p=0.002) and satisfaction (B=0.326, SE=0.114, p=0.005). This study demonstrates that transformational leadership and contingent reward positively influence leadership efficiency in healthcare researchers. Although we did not show an association between leadership behaviours and research performance metrics, further studies using contextual performance measures at team and organisational levels are required. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

The clinical impact of contemporary stress echocardiography in morbid obesity for the assessment of coronary artery disease.

PubMed

Shah, Benoy N; Zacharias, Konstantinos; Pabla, Jatinder S; Karogiannis, Nikolaos; Calicchio, Francesca; Balaji, Gothandaraman; Alhajiri, Abdalla; Ramzy, Ihab S; Elghamaz, Ahmed; Gurunathan, Sothinathan; Khattar, Rajdeep S; Senior, Roxy

2016-03-01

Non-invasive cardiac imaging may suffer from poor image quality in morbidly obese individuals. This study aimed to determine the clinical value of contemporary stress echocardiography (SE) in morbidly obese patients referred for assessment of suspected coronary artery disease (CAD). This prospective, multicentre observational study was conducted in two district hospitals and one tertiary centre in London, UK. Individuals with body mass index ≥35 kg/m(2) referred for SE were evaluated. The percentage of patients with obstructive CAD on coronary angiography, following abnormal SE, was assessed. Patient outcomes were determined with follow-up for the composite end-point of all-cause mortality, myocardial infarction and late revascularisation. Over a 13-month period, 209 morbidly obese patients underwent SE, and contrast agent was used in 96% of patients. A diagnostic result was obtained in 200/209 (96%) patients. Of 32 (15%) patients with inducible ischaemia, 25 underwent angiography, 22 (88%) had corresponding significant CAD and, of these, 16 (77%) underwent revascularisation. Conversely, only 2/157 patients (1.3%) with normal SE underwent angiography, and none underwent revascularisation. Over a mean follow-up period of 17.8±5.4 months, there were nine events. The annualised cardiac event rate after a normal SE was 0.95%. Events were more frequent in patients with inducible ischaemia versus those without ischaemia (5/32 (15.6%) vs 4/153 (2.6%); p=0.002). Ejection fraction <50% (HR 9.5; 95% CI 2.4 to 38.0; p=0.002) and inducible ischaemia (HR 9.4; 95% CI 2.5 to 35.8; p=0.001) were predictors of outcome on univariable Cox regression analysis. Contemporary SE has excellent feasibility and positive predictive value and resulted in appropriate risk stratification of symptomatic patients with significant obesity. A normal SE portends an excellent outcome over the short-intermediate term in this high-risk patient population. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

NATO Transformation and Operational Support in the Canadian Forces: Part 2: The Military and Institutional Dimensions

DTIC Science & Technology

2010-11-01

Dimensions David Rudd; DRDC CORA TR 2010-246; R & D pour la défense Canada – CORA; Novembre 2010. Contexte: La première décennie du XXIe siècle a...décennie. D’ici novembre 2010, lorsque les chefs d’État et de gouvernement se rassembleront à Lisbonne, il faudrait établir un consensus notamment...12 Jiri Kominek, “Czech Republic and Slovakia look to defence co-operation,” Jane’s Defence Weekly, 13 August 2010, http://www4.janes.com/subscribe

Memnonia Sulci

NASA Image and Video Library

2017-01-09

Today's VIS image shows some of the extensive wind etched terrain in Memnonia Sulci, located south west of Olympus Mons. The linear ridges are called yardangs and form by wind removal of semi-cemented material. The ridges are parallel to wind direction, so the predominate winds that created the yardangs in this image blew NW/SE. At the bottom of the image several of the ridges have been eroded into smaller ridges aligned perpendicular to the large yardangs, indicating winds at a different angle. Orbit Number: 66197 Latitude: -5.91796 Longitude: 183.886 Instrument: VIS Captured: 2016-11-15 13:08 http://photojournal.jpl.nasa.gov/catalog/PIA21283

Design and Implementation of A DICOM PACS With Secure Access Via Internet

DTIC Science & Technology

2001-10-25

which we have called SINFIM ( Sistema de INFormación de Imágenes Médicas). This system permits the automatic acquisition of DICOM images [2] [3...1] MA. Martínez, AJR. Jiménez, BV. Medina, LJ. Azpiroz. “Los Sistemas PACS”. [Last access 08/12/2000]. Available URL http://itzamna.uam.mx...junio, por el que se aprueba el Reglamento de medidas de seguridad de los ficheros automatizados que contengan datos de carácter personal” (Boletín Oficial del Estado, número 151, de 25 de junio de 1999)

The Carnegie Supernova Project I. Analysis of stripped-envelope supernova light curves

NASA Astrophysics Data System (ADS)

Taddia, F.; Stritzinger, M. D.; Bersten, M.; Baron, E.; Burns, C.; Contreras, C.; Holmbo, S.; Hsiao, E. Y.; Morrell, N.; Phillips, M. M.; Sollerman, J.; Suntzeff, N. B.

2018-02-01

Stripped-envelope (SE) supernovae (SNe) include H-poor (Type IIb), H-free (Type Ib), and He-free (Type Ic) events thought to be associated with the deaths of massive stars. The exact nature of their progenitors is a matter of debate with several lines of evidence pointing towards intermediate mass (Minit< 20 M⊙) stars in binary systems, while in other cases they may be linked to single massive Wolf-Rayet stars. Here we present the analysis of the light curves of 34 SE SNe published by the Carnegie Supernova Project (CSP-I) that are unparalleled in terms of photometric accuracy and wavelength range. Light-curve parameters are estimated through the fits of an analytical function and trends are searched for among the resulting fit parameters. Detailed inspection of the dataset suggests a tentative correlation between the peak absolute B-band magnitude and Δm15(B), while the post maximum light curves reveals a correlation between the late-time linear slope and Δm15. Making use of the full set of optical and near-IR photometry, combined with robust host-galaxy extinction corrections, comprehensive bolometric light curves are constructed and compared to both analytic and hydrodynamical models. This analysis finds consistent results among the two different modeling techniques and from the hydrodynamical models we obtained ejecta masses of 1.1-6.2M⊙, 56Ni masses of 0.03-0.35M⊙, and explosion energies (excluding two SNe Ic-BL) of 0.25-3.0 × 1051 erg. Our analysis indicates that adopting κ = 0.07 cm2 g-1 as the mean opacity serves to be a suitable assumption when comparing Arnett-model results to those obtained from hydrodynamical calculations. We also find that adopting He I and O I line velocities to infer the expansion velocity in He-rich and He-poor SNe, respectively, provides ejecta masses relatively similar to those obtained by using the Fe II line velocities, although the use of Fe II as a diagnostic does imply higher explosion energies. The inferred range of ejecta masses are compatible with intermediate mass (MZAMS ≤ 20M⊙) progenitor stars in binary systems for the majority of SE SNe. Furthermore, our hydrodynamical modeling of the bolometric light curves suggests a significant fraction of the sample may have experienced significant mixing of 56Ni, particularly in the case of SNe Ic. Based on observations collected at Las Campanas Observatory.Bolometric light curve tables are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/609/A136

Spatial resolution test of a beam diagnostic system for DESIREE

NASA Astrophysics Data System (ADS)

Das, Susanta; Kallberg, A.

2010-11-01

A diagnostic system based on the observation of low energy ( ˜ 10 eV) secondary electrons (SE) produced by a beam, striking a metallic foil has been built to monitor and to cover the wide range of beam intensities and energies for Double ElectroStatic Ion Ring ExpEriment [1,2].The system consists of a Faraday cup to measure the beam current, a collimator with circular apertures of different diameters to measure the spatial resolution of the system, a beam profile monitoring system (BPMS), and a control unit. The BPMS, in turn, consists of an aluminim (Al) foil, a grid placed in front of the Al foil to accelerate the SE, position sensitive MCP, fluorescent screen, and a CCD camera to capture the images. The collimator contains a set of circular holes of different diameters and separations (d) between them. The collimator cuts out from the beam areas equal to the holes with separation d mm between the beams centers and creates well separated (distinguishable) narrow beams of approximately same intensity close to each other. A 10 keV proton beam was used. The spatial resolution of the system was tested for different Al plate and MCP voltages and resolution of better than 2 mm was achieved. Ref.: 1. K. Kruglov {et al}., NIM A 441 (2000) 595; 701 (2002) 193c, 2. MSL and Atomic Physics, Stockholm Univ.(www.msl.se, http://www.atom.physto.se/Cederquist/desiree/web/hc.html).

Pressure-Photoluminescence Study of the Zn Vacancy and Donor Zn-Vacancy Complexes in ZnSe

NASA Astrophysics Data System (ADS)

Iota, V.; Weinstein, B. A.

1997-03-01

We report photoluminescence (PL) results to 65kbar (at 8K) on n-type electron irradiated ZnSe containing high densities of isolated Zn vacancies (V_Zn) and donor-V_Zn complexes (A-centers).^1 Isotropic pressure is applied using a diamond-anvil cell with He medium, and laser excitations above and below the ZnSe bandgap (2.82eV) are employed. The 1 atm. spectra exhibit excitonic lines, shallow donor-acceptor pair (DAP) peaks, and two broad bands due to DAP transitions between shallow donors and deep acceptor states at A-centers (2.07eV) or V_Zn (1.72eV). At all pressures, these broad bands are prominent only for sub-gap excitation, which results in: i) A-center PL at energies above the laser line, and ii) strong enhancement of the first LO-replica in the shallow DAP series compared to 3.41eV UV excitation. This suggests that sub-gap excitation produces long-lived metastable acceptor states. The broad PL bands shift to higher energy with pressure faster than the ZnSe direct gap, indicating that compression causes the A-center and V_Zn deep acceptor levels to approach the hole continuum. This behavior is similar to that found by our group for P and As deep acceptor levels in ZnSe, supporting the view that deep substitutional defects often resemble the limiting case of a vacancy. ^1D. Y. Jeon, H. P. Gislason, G. D. Watkins Phys. Rev. B 48, 7872 (1993); we thank G. D. Watkins for providing the samples. (figures)

Stellar laboratories . IX. New Se v, Sr iv-vii, Te vi, and I vi oscillator strengths and the Se, Sr, Te, and I abundances in the hot white dwarfs G191-B2B and RE 0503-289

NASA Astrophysics Data System (ADS)

Rauch, T.; Quinet, P.; Knörzer, M.; Hoyer, D.; Werner, K.; Kruk, J. W.; Demleitner, M.

2017-10-01

Context. To analyze spectra of hot stars, advanced non-local thermodynamic equilibrium (NLTE) model-atmosphere techniques are mandatory. Reliable atomic data is crucial for the calculation of such model atmospheres. Aims: We aim to calculate new Sr iv-vii oscillator strengths to identify for the first time Sr spectral lines in hot white dwarf (WD) stars and to determine the photospheric Sr abundances. To measure the abundances of Se, Te, and I in hot WDs, we aim to compute new Se v, Te vi, and I vi oscillator strengths. Methods: To consider radiative and collisional bound-bound transitions of Se v, Sr iv - vii, Te vi, and I vi in our NLTE atmosphere models, we calculated oscillator strengths for these ions. Results: We newly identified four Se v, 23 Sr v, 1 Te vi, and three I vi lines in the ultraviolet (UV) spectrum of RE 0503-289. We measured a photospheric Sr abundance of 6.5+ 3.8-2.4× 10-4 (mass fraction, 9500-23 800 times solar). We determined the abundances of Se (1.6+ 0.9-0.6× 10-3, 8000-20 000), Te (2.5+ 1.5-0.9× 10-4, 11 000-28 000), and I (1.4+ 0.8-0.5× 10-5, 2700-6700). No Se, Sr, Te, and I line was found in the UV spectra of G191-B2B and we could determine only upper abundance limits of approximately 100 times solar. Conclusions: All identified Se v, Sr v, Te vi, and I vi lines in the UV spectrum of RE 0503-289 were simultaneously well reproduced with our newly calculated oscillator strengths. Based on observations with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26666. Based on observations made with the NASA-CNES-CSA Far Ultraviolet Spectroscopic Explorer. Full Tables A.15 to A.21 are only available via the German Astrophysical Virtual Observatory (GAVO) service TOSS (http://dc.g-vo.org/TOSS).

Web Intervention for Adolescents Affected by Disaster: Population-Based Randomized Controlled Trial.

PubMed

Ruggiero, Kenneth J; Price, Matthew; Adams, Zachary; Stauffacher, Kirstin; McCauley, Jenna; Danielson, Carla Kmett; Knapp, Rebecca; Hanson, Rochelle F; Davidson, Tatiana M; Amstadter, Ananda B; Carpenter, Matthew J; Saunders, Benjamin E; Kilpatrick, Dean G; Resnick, Heidi S

2015-09-01

To assess the efficacy of Bounce Back Now (BBN), a modular, Web-based intervention for disaster-affected adolescents and their parents. A population-based randomized controlled trial used address-based sampling to enroll 2,000 adolescents and parents from communities affected by tornadoes in Joplin, MO, and several areas in Alabama. Data collection via baseline and follow-up semi-structured telephone interviews was completed between September 2011 and August 2013. All families were invited to access the BBN study Web portal irrespective of mental health status at baseline. Families who accessed the Web portal were assigned randomly to 1 of 3 groups: BBN, which featured modules for adolescents and parents targeting adolescents' mental health symptoms; BBN plus additional modules targeting parents' mental health symptoms; or assessment only. The primary outcomes were adolescent symptoms of posttraumatic stress disorder (PTSD) and depression. Nearly 50% of families accessed the Web portal. Intent-to-treat analyses revealed time × condition interactions for PTSD symptoms (B = -0.24, SE = 0.08, p < .01) and depressive symptoms (B = -0.23, SE = 0.09, p < .01). Post hoc comparisons revealed fewer PTSD and depressive symptoms for adolescents in the experimental versus control conditions at 12-month follow-up (PTSD: B = -0.36, SE = 0.19, p = .06; depressive symptoms: B = -0.42, SE = 0.19, p = 0.03). A time × condition interaction also was found that favored the BBN versus BBN + parent self-help condition for PTSD symptoms (B = 0.30, SE = 0.12, p = .02) but not depressive symptoms (B = 0.12, SE = 0.12, p = .33). Results supported the feasibility and initial efficacy of BBN as a scalable disaster mental health intervention for adolescents. Technology-based solutions have tremendous potential value if found to reduce the mental health burden of disasters. Web-based Intervention for Disaster-Affected Youth and Families; http://clinicaltrials.gov; NCT01606514. Copyright © 2015 American Academy of Child and Adolescent Psychiatry. All rights reserved.

For Whom Does It Work? Moderators of Outcome on the Effect of a Transdiagnostic Internet-Based Maintenance Treatment After Inpatient Psychotherapy: Randomized Controlled Trial

PubMed Central

Gollwitzer, Mario; Riper, Heleen; Cuijpers, Pim; Baumeister, Harald; Berking, Matthias

2013-01-01

Background Recent studies provide evidence for the effectiveness of Internet-based maintenance treatments for mental disorders. However, it is still unclear which participants might or might not profit from this particular kind of treatment delivery. Objective The study aimed to identify moderators of treatment outcome in a transdiagnostic Internet-based maintenance treatment (TIMT) offered to patients after inpatient psychotherapy for mental disorders in routine care. Methods Using data from a randomized controlled trial (N=400) designed to test the effectiveness of TIMT, we performed secondary analyses to identify factors moderating the effects of TIMT (intervention) when compared with those of a treatment-as-usual control condition. TIMT involved an online self-management module, asynchronous patient–therapist communication, a peer support group, and online-based progress monitoring. Participants in the control condition had unstructured access to outpatient psychotherapy, standardized outpatient face-to-face continuation treatment, and psychotropic management. Self-reports of psychopathological symptoms and potential moderators were assessed at the start of inpatient treatment (T1), at discharge from inpatient treatment/start of TIMT (T2), and at 3-month (T3) and 12-month follow-up (T4). Results Education level, positive outcome expectations, and diagnoses significantly moderated intervention versus control differences regarding changes in outcomes between T2 and T3. Only education level moderated change differences between T2 and T4. The effectiveness of the intervention (vs control) was more pronounced among participants with a low (vs high) education level (T2-T3: B=–0.32, SE 0.16, P=.049; T2-T4: B=–0.42, SE 0.21, P=.049), participants with high (vs low) positive outcome expectations (T2-T3: B=–0.12, SE 0.05, P=.02) and participants with anxiety disorder (vs mood disorder) (T2-T3: B=–0.43, SE 0.21, P=.04). Simple slope analyses revealed that despite some subgroups benefiting less from the intervention than others, all subgroups still benefited significantly. Conclusions This transdiagnostic Internet-based maintenance treatment might be suitable for a wide range of participants differing in various clinical, motivational, and demographic characteristics. The treatment is especially effective for participants with low education levels. These findings may generalize to other Internet-based maintenance treatments. Trial Registration International Standard Randomized Controlled Trial Number (ISRCTN): 28632626; http://www.controlled-trials.com/isrctn/pf/28632626 (Archived by WebCite at http://www.webcitation.org/6IqZjTLrx). PMID:24113764

SLAM, a Mathematica interface for SUSY spectrum generators

NASA Astrophysics Data System (ADS)

Marquard, Peter; Zerf, Nikolai

2014-03-01

We present and publish a Mathematica package, which can be used to automatically obtain any numerical MSSM input parameter from SUSY spectrum generators, which follow the SLHA standard, like SPheno, SOFTSUSY, SuSeFLAV or Suspect. The package enables a very comfortable way of numerical evaluations within the MSSM using Mathematica. It implements easy to use predefined high scale and low scale scenarios like mSUGRA or mhmax and if needed enables the user to directly specify the input required by the spectrum generators. In addition it supports an automatic saving and loading of SUSY spectra to and from a SQL data base, avoiding the rerun of a spectrum generator for a known spectrum. Catalogue identifier: AERX_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AERX_v1_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 4387 No. of bytes in distributed program, including test data, etc.: 37748 Distribution format: tar.gz Programming language: Mathematica. Computer: Any computer where Mathematica version 6 or higher is running providing bash and sed. Operating system: Linux. Classification: 11.1. External routines: A SUSY spectrum generator such as SPheno, SOFTSUSY, SuSeFLAV or SUSPECT Nature of problem: Interfacing published spectrum generators for automated creation, saving and loading of SUSY particle spectra. Solution method: SLAM automatically writes/reads SLHA spectrum generator input/output and is able to save/load generated data in/from a data base. Restrictions: No general restrictions, specific restrictions are given in the manuscript. Running time: A single spectrum calculation takes much less than one second on a modern PC.

Hyperdiploidy with 58-66 chromosomes in childhood B-acute lymphoblastic leukemia is highly curable: 58951 CLG-EORTC results.

PubMed

Dastugue, Nicole; Suciu, Stefan; Plat, Geneviève; Speleman, Frank; Cavé, Hélène; Girard, Sandrine; Bakkus, Marleen; Pagès, Marie Pierre; Yakouben, Karima; Nelken, Brigitte; Uyttebroeck, Anne; Gervais, Carine; Lutz, Patrick; Teixeira, Manuel R; Heimann, Pierre; Ferster, Alice; Rohrlich, Pierre; Collonge, Marie Agnès; Munzer, Martine; Luquet, Isabelle; Boutard, Patrick; Sirvent, Nicolas; Karrasch, Matthias; Bertrand, Yves; Benoit, Yves

2013-03-28

The aim of our study was to analyze the factors contributing to heterogeneity of prognosis in patients with hyperdiploidy>50 chromosomes (HD>50), a group of B-cell precursor acute lymphoblastic leukemia with favorable outcome. The 541 HD>50 patients registered prospectively in the 58951 European Organisation for Research and Treatment of Cancer (EORTC) Children's Leukemia Group (CLG) trial, identified by karyotype (446 patients) and by DNA index (DI) (490 patients), had a 6-year event-free survival (EFS) of 89.0% (standard error [SE] = 1.5%) and a 6-year overall survival (OS) of 95.9% (SE = 0.9%). The strongest prognostic factor was the modal number of chromosomes (MNC): the 6-year EFS of 51-53, 54-57, and 58-66 MNC groups were 80%, 89%, and 99%, respectively (P < .0001). Ploidy assessed by DI was also a favorable factor: the higher the DI, the better the outcome. The 6-year EFS of the 3 subgroups of DI < 1.16/≥1.16-<1.24/≥1.24 were 83%, 90%, and 95%, respectively (P = .009). All usual combinations of trisomies (chromosomes 4, 10, 17, 18) were significant favorable factors but had lower EFS when MNC was lower than 58. In multivariate analysis, MNC remained the strongest factor. Consequently, the best indicator for excellent outcome was ploidy assessed by karyotype because patients with 58-66 chromosomes stood every chance of being cured (OS of 100% at 6-year follow-up) with less-intensive therapy. This trial was registered at www.clinicaltrials.gov as #NCT00003728. Registered: http://www.eortc.org/, http://clinicaltrials.gov/show/NCT00003728.

Caries experience of some countries and areas expressed by the Significant Caries Index.

PubMed

Nishi, Makiko; Stjernswärd, Jayanthi; Carlsson, Peter; Bratthall, Douglas

2002-08-01

To calculate and present the caries prevalence for some countries/states among 12-year-olds, expressed as Significant Caries Index (SiC Index) and to analyse the relationship between the mean DMFT and the SiC Index for these countries. SiC Index is the mean DMFT of the one-third of a population with the highest caries values. An Excel(R) application for calculating SiC was developed (http://www.whocollab.od.mah.se/expl/siccalculation.xls) and indices were calculated from the data collected for 14 countries and one state from the Country/Area Profile Programme (http://www.whocollab.od.mah.se/index.html). To investigate the provinces of a country that had already reached the proposed SiC Index goal of 3 DMFT among the 12-year-olds, data for 17 counties and a city from Sweden were collected and the respective mean DMFT and SiC Indices calculated. The mean DMFT varied from 1.0 to 8.5 and the SiC Index varied from 2.8 to 13.7 in the national data. Jamaica, Senegal and Sweden were the only three countries that showed SiC Indices that were less than 3 DMFT. The mean DMFT varied from 0.5 to 1.4 and the SiC Index varied from 1.4 to 3.6 in the Swedish county/city data examined. A strong linear relationship between the mean DMFT and the SiC Index was found for the populations presented in this study. The SiC Index is an indicator that reflects the situation among the most caries-exposed individuals and could be included in future population-based oral health surveys together with the mean DMFT.

Communicating and visualizing data quality through Web Map Services

NASA Astrophysics Data System (ADS)

Roberts, Charles; Blower, Jon; Maso, Joan; Diaz, Daniel; Griffiths, Guy; Lewis, Jane

2014-05-01

The sharing and visualization of environmental data through OGC Web Map Services is becoming increasingly common. However, information about the quality of data is rarely presented. (In this presentation we consider mostly data uncertainty as a measure of quality, although we acknowledge that many other quality measures are relevant to the geoscience community.) In the context of the GeoViQua project (http://www.geoviqua.org) we have developed conventions and tools for using WMS to deliver data quality information. The "WMS-Q" convention describes how the WMS specification can be used to publish quality information at the level of datasets, variables and individual pixels (samples). WMS-Q requires no extensions to the WMS 1.3.0 specification, being entirely backward-compatible. (An earlier version of WMS-Q was published as OGC Engineering Report 12-160.) To complement the WMS-Q convention, we have also developed extensions to the OGC Symbology Encoding (SE) specification, enabling uncertain geoscience data to be portrayed using a variety of visualization techniques. These include contours, stippling, blackening, whitening, opacity, bivariate colour maps, confidence interval triangles and glyphs. There may also be more extensive applications of these methods beyond the visual representation of uncertainty. In this presentation we will briefly describe the scope of the WMS-Q and "extended SE" specifications and then demonstrate the innovations using open-source software based upon ncWMS (http://ncwms.sf.net). We apply the tools to a variety of datasets including Earth Observation data from the European Space Agency's Climate Change Initiative. The software allows uncertain raster data to be shared through Web Map Services, giving the user fine control over data visualization.

Using ecological momentary assessment to test the effectiveness of a web-based brief alcohol intervention over time among heavy-drinking students: randomized controlled trial.

PubMed

Voogt, Carmen; Kuntsche, Emmanuel; Kleinjan, Marloes; Poelen, Evelien; Engels, Rutger

2014-01-08

Web-based brief alcohol interventions are effective in reducing alcohol use among students when measured at limited follow-up time points. To date, no studies have tested Web-based brief alcohol intervention effectiveness over time by using a large number of measurements. Testing whether the What Do You Drink (WDYD) Web-based brief alcohol intervention can sustain a reduction in alcohol use among heavy-drinking students aged 18-24 years at 1-, 3-, and 6-month follow-up intervals. A purely Web-based, 2-arm, parallel-group randomized controlled trial applying an ecological momentary assessment approach with 30 weekly measurements was conducted in the Netherlands (2010-2011). Participants were recruited offline and online. A total of 907 participants were randomized into the experimental condition (n=456) including the single-session and fully automated WDYD intervention, or into the control condition (n=451) including assessment only. Weekly alcohol consumption and frequency of binge drinking were the self-assessed outcome measures. Attrition rates of the 907 participants were 110 (12.1%), 130 (14.3%), and 162 (17.9%) at 1-, 3-, and 6-month follow-up intervals, respectively. Latent growth curve analyses according to the intention-to-treat principle revealed that participants in the experimental condition had significantly lower weekly alcohol consumption compared to participants in the control condition that was sustained at 3-month follow-up (intercept=-2.60, P<.001; slope=0.16, P=.08). Additional linear regression analyses indicated that this intercept difference resulted from significantly higher levels of alcohol units per week for participants in the control condition compared to those in the experimental condition at 1-month (beta=-2.56, SE 0.74, Cohen's d=0.20, P=.001), 3-month (beta=-1.76, SE 0.60, Cohen's d=0.13, P=.003), and 6-month (beta=-1.21, SE 0.58, Cohen's d=0.09, P=.04) follow-up intervals. Latent growth curve analyses further indicated that participants in the experimental condition had a significantly lower frequency of binge drinking compared to participants in the control condition that was sustained at 6-month follow-up (intercept=-0.14, P=.01; slope=0.004, P=.19). This intercept difference resulted from higher levels in this outcome for participants in the control condition relative to participants in the experimental condition at 1-month (beta=-1.15, SE 0.06, Cohen's d=0.16, P=.01), 3-month (beta=-0.12, SE 0.05, Cohen's d=0.09, P=.01), and 6-month (beta=-0.09, SE 0.05, Cohen's d=0.03, P=.045) follow-up intervals. The WDYD intervention was shown to be effective in preventing an increase in weekly alcohol consumption and frequency of binge drinking directly after the intervention. This effect was sustained 3 and 6 months after the intervention. Netherlands Trial Register NTR2665; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2665 (Archived by WebCite at http://webcitation.org/6LuQVn12M).

Increased colonic bile acid exposure: a relevant factor for symptoms and treatment in IBS.

PubMed

Bajor, Antal; Törnblom, Hans; Rudling, Mats; Ung, Kjell-Arne; Simrén, Magnus

2015-01-01

Bile acids may play a role in the pathogenesis of IBS. We investigated the potential effects of bile acids entering the colon and its role in the symptom pattern in IBS. We measured 75Se-labelled homocholic acid-taurine (75SeHCAT) retention, and serum levels of 7α-hydroxy-4-cholesten-3-one (C4) and fibroblast growth factor (FGF) 19 in patients with IBS (n=141) and control subjects (75SeHCAT n=29; C4 and FGF19 n=435). In patients with IBS stool frequency and form, as well as GI symptom severity were registered, and in a proportion of patients colonic transit time and rectal sensitivity were measured (n=66). An 8-week open-label treatment with colestipol was offered to patients with 75SeHCAT <20%, and the effect of treatment was evaluated with IBS severity scoring system and adequate relief of IBS symptoms. Compared with controls, patients with IBS had lower 75SeHCAT values (p=0.005), higher C4c levels (C4 corrected for cholesterol) (p<0.001), but similar FGF19 levels. Abnormal 75SeHCAT retention (<10%) was seen in 18% of patients, whereas 23% had elevated C4c levels. Patients with IBS with 75SeHCAT retention <10% had more frequent stools, accelerated colonic transit time, rectal hyposensitivity, a higher body mass index, higher C4c and lower FGF19 levels. Colestipol treatment improved IBS symptoms (IBS severity scoring system 220±109 vs. 277±106; p<0.01), and 15/27 patients fulfilled criteria for treatment response (adequate relief ≥50% of weeks 5-8). Increased colonic bile acid exposure influences bowel habit and colonic transit time in patients with IBS. A high response rate to open label treatment with colestipol supports this, but placebo-controlled studies are warranted. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Educating the Public about the 2017 Total Solar Eclipse

NASA Astrophysics Data System (ADS)

Pasachoff, Jay M.

2017-01-01

On behalf of the International Astronomical Union's Working Group on Solar Eclipses, I have long worked to bring knowledge about eclipses and how to observe the safely to the people of the various countries from which partial, annular, or total solar eclipses are visible. In 2017, we have first a chance to educate the people of South America on the occasion of the February 26 annular eclipse through southern Chile and Argentina that is partial throughout almost the entire continent (and an eclipse workshop will be held February 22-24 in Esquel, Argentina: http://sion.frm.utn.edu.ar/WDEAII) and then a chance to educate the 300 million people of the United States and others in adjacent countries as far south as northern South America about the glories of totality and how to observe partial phases. Our website, a compendium of links to information about maps, safe observing, science, and more is at http://eclipses.info. We link to important mapping sites at EclipseWise.com, GreatAmericanEclipse.com, and http://xjubier.free.fr/en/site_pages/solar_eclipses/xSE_GoogleMap3.php?Ecl=+20170821&Acc=2&Umb=1&Lmt=1&Mag=1&Max=1, and information about cloudiness statistics at http://eclipsophile.com, as well as simulation sites at https://svs.gsfc.nasa.gov/cgi-bin/details.cgi?aid=4314 and http://eyes.jpl.nasa.gov. The American Astronomical Society's task force on the 2017 eclipse has a website at http://eclipse.aas.org. We are working to disseminate accurate information about how and why to observe the total solar eclipse, trying among other things to head off common misinformation about the hazards of looking at the sun at eclipses or otherwise. About 12 million Americans live within the 70-mile-wide band of totality, and we encourage others to travel into it, trying to make clear the difference between even a 99% partial eclipse and a total eclipse, with its glorious Baily's beads, diamond rings, and totality that on this occasion lasts between 2 minutes and 2 minutes 40 seconds on the centerline. Our research on the 2017 total solar eclipse is supported by grants from the Committee for Research and Exploration of the National Geographic Society and from the Solar Terrestrial Program of the Atmospheric and Geospace Sciences Division of the National Science Foundation.

Molray--a web interface between O and the POV-Ray ray tracer.

PubMed

Harris, M; Jones, T A

2001-08-01

A publicly available web-based interface is presented for producing high-quality ray-traced images and movies from the molecular-modelling program O [Jones et al. (1991), Acta Cryst. A47, 110-119]. The interface allows the user to select O-plot files and set parameters to create standard input files for the popular ray-tracing renderer POV-Ray, which can then produce publication-quality still images or simple movies. To ensure ease of use, we have made this service available to the O user community via the World Wide Web. The public Molray server is available at http://xray.bmc.uu.se/molray.

Flooding at Iron-Ore Mine, SE Brazil

NASA Image and Video Library

2015-11-14

On Nov. 5, 2015, a dam at an iron-ore mine in southeastern Brazil burst, sending a wall of water, clay-red mud and debris downstream, overwhelming several villages in the path as seen by NASA Terra spacecraft. The Germano mine is near the town of Mariana in Minas Gerais state. The region is seen in this image from the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) instrument aboard NASA's Terra spacecraft was acquired Nov. 12, 2015, covers an area of 6.8 by 14.3 miles (11 by 23 kilometers), and is located at 20.2 degrees south, 43.5 degrees west. http://photojournal.jpl.nasa.gov/catalog/PIA20156

ProQ3D: improved model quality assessments using deep learning.

PubMed

Uziela, Karolis; Menéndez Hurtado, David; Shu, Nanjiang; Wallner, Björn; Elofsson, Arne

2017-05-15

Protein quality assessment is a long-standing problem in bioinformatics. For more than a decade we have developed state-of-art predictors by carefully selecting and optimising inputs to a machine learning method. The correlation has increased from 0.60 in ProQ to 0.81 in ProQ2 and 0.85 in ProQ3 mainly by adding a large set of carefully tuned descriptions of a protein. Here, we show that a substantial improvement can be obtained using exactly the same inputs as in ProQ2 or ProQ3 but replacing the support vector machine by a deep neural network. This improves the Pearson correlation to 0.90 (0.85 using ProQ2 input features). ProQ3D is freely available both as a webserver and a stand-alone program at http://proq3.bioinfo.se/. arne@bioinfo.se. Supplementary data are available at Bioinformatics online. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

FilTer BaSe: A web accessible chemical database for small compound libraries.

PubMed

Kolte, Baban S; Londhe, Sanjay R; Solanki, Bhushan R; Gacche, Rajesh N; Meshram, Rohan J

2018-03-01

Finding novel chemical agents for targeting disease associated drug targets often requires screening of large number of new chemical libraries. In silico methods are generally implemented at initial stages for virtual screening. Filtering of such compound libraries on physicochemical and substructure ground is done to ensure elimination of compounds with undesired chemical properties. Filtering procedure, is redundant, time consuming and requires efficient bioinformatics/computer manpower along with high end software involving huge capital investment that forms a major obstacle in drug discovery projects in academic setup. We present an open source resource, FilTer BaSe- a chemoinformatics platform (http://bioinfo.net.in/filterbase/) that host fully filtered, ready to use compound libraries with workable size. The resource also hosts a database that enables efficient searching the chemical space of around 348,000 compounds on the basis of physicochemical and substructure properties. Ready to use compound libraries and database presented here is expected to aid a helping hand for new drug developers and medicinal chemists. Copyright © 2017 Elsevier Inc. All rights reserved.

Effects of Vascular and Nonvascular Adverse Events and of Extended-Release Niacin With Laropiprant on Health and Healthcare Costs.

PubMed

Kent, Seamus; Haynes, Richard; Hopewell, Jemma C; Parish, Sarah; Gray, Alastair; Landray, Martin J; Collins, Rory; Armitage, Jane; Mihaylova, Borislava

2016-07-01

Extended-release niacin with laropiprant did not significantly reduce the risk of major vascular events and increased the risk of serious adverse events in Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events (HPS2-THRIVE), but its net effects on health and healthcare costs are unknown. 25 673 participants aged 50 to 80 years with previous cardiovascular disease were randomized to 2 g of extended-release niacin with 40 mg of laropiprant daily versus matching placebo, in addition to effective statin-based low-density lipoprotein cholesterol-lowering treatment. The net effects of niacin-laropiprant on quality-adjusted life years and hospital care costs (2012 UK £; converted into US $ using purchasing power parity index) during 4 years in HPS2-THRIVE were evaluated using estimates of the impact of serious adverse events on health-related quality of life and hospital care costs. During the study, participants assigned niacin-laropiprant experienced marginally but not statistically significantly lower survival (0.012 fewer years [standard error (SE) 0.007]), fewer quality-adjusted life years (0.023 [SE 0.007] fewer using UK EQ-5D scores; 0.020 [SE 0.006] fewer using US EQ-5D scores) and accrued greater hospital costs (UK £101 [SE £37]; US $145 [SE $53]). Stroke, heart failure, musculoskeletal events, gastrointestinal events, and infections were associated with significant decreases in health-related quality of life in both the year of the event and in subsequent years. All serious vascular and nonvascular events were associated with substantial increases in hospital care costs. In HPS2-THRIVE, the addition of extended-release niacin-laropiprant to statin-based therapy reduced quality of life-adjusted survival and increased hospital costs. URL: http://clinicaltrials.gov. Unique identifier: NCT00461630. © 2016 American Heart Association, Inc.

Intraoperative aberrometry-based aphakia refraction in patients with cataract: status and options.

PubMed

Huelle, Jan O; Druchkiv, Vasyl; Habib, Nabil E; Richard, Gisbert; Katz, Toam; Linke, Stephan J

2017-02-01

To explore the application of intraoperative wavefront aberrometry (IWA) for aphakia-based biometry using three existing formulae derived from autorefractive retinoscopy and introducing new improved formulae. In 74 patients undergoing cataract surgery, three repeated measurements of aphakic spherical equivalent (SE) were taken. All measurements were objectively graded for their quality and evaluated with the 'limits of agreement' approach. ORs were calculated and analysis of variance was applied. The intraocular lens (IOL) power that would have given the target refraction was back-calculated from manifest refraction at 3 months postoperatively. Regression analysis was performed to generate two aphakic SE-based formulae for predicting this IOL. The accuracy of the formulae was determined by comparing them to conventional biometry and published aphakia formulae. In 32 eyes, three consecutive aphakic measurements were successful. Objective parameters of IWA map quality significantly impacted measurement variability (p<0.05). The limits of agreement of repeated aphakic SE readings were +0.66 dioptre (D) and -0.69 D. Intraoperative biometry by our formula resulted in 25% and 53% of all cases ±0.50D and ±1.00 D within SE target, respectively. A second formula that took axial length (AL) into account resulted in improved ratios of 41% and 70%, respectively. A reliable application of IWA to calculate IOL power during routine cataract surgery may not be feasible given the high rate of measurement failures and the large variations of the readings. To enable reliable IOL calculation from IWA, measurement precision must be improved and aphakic IOL formulae need to be fine-tuned. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Mentoring perception and academic performance: an Academic Health Science Centre survey.

PubMed

Athanasiou, Thanos; Patel, Vanash; Garas, George; Ashrafian, Hutan; Shetty, Kunal; Sevdalis, Nick; Panzarasa, Pietro; Darzi, Ara; Paroutis, Sotirios

2016-10-01

To determine the association between professors' self-perception of mentoring skills and their academic performance. Two hundred and fifteen professors from Imperial College London, the first Academic Health Science Centre (AHSC) in the UK, were surveyed. The instrument adopted was the Mentorship Skills Self-Assessment Survey. Statement scores were aggregated to provide a score for each shared core, mentor-specific and mentee-specific skill. Univariate and multivariate regression analyses were used to evaluate their relationship with quantitative measures of academic performance (publications, citations and h-index). There were 104 professors that responded (response rate 48%). There were no statistically significant negative correlations between any mentoring statement and any performance measure. In contrast, several mentoring survey items were positively correlated with academic performance. The total survey score for frequency of application of mentoring skills had a statistically significant positive association with number of publications (B=0.012, SE=0.004, p=0.006), as did the frequency of acquiring mentors with number of citations (B=1.572, SE=0.702, p=0.030). Building trust and managing risks had a statistically significant positive association with h-index (B=0.941, SE=0.460, p=0.047 and B=0.613, SE=0.287, p=0.038, respectively). This study supports the view that mentoring is associated with high academic performance. Importantly, it suggests that frequent use of mentoring skills and quality of mentoring have positive effects on academic performance. Formal mentoring programmes should be considered a fundamental part of all AHSCs' configuration. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Federal actions to incentivise state adoption of 0.08 g/dL blood alcohol concentration laws.

PubMed

Tung, Gregory J; Vernick, Jon S; Stuart, Elizabeth A; Webster, Daniel W; Gielen, Andrea C

2017-10-01

To model rates of 0.08 g/dL blood alcohol concentration (BAC) per se law implementation among the states associated with (1) a federal incentive grant programme and (2) a threat from the federal government to withhold highway transportation funds. An observational study of state-level 0.08 g/dL BAC per se law enactment among all 50 US states from 1982 to 2006 using a parametric survival analysis to assess the time-dependent risk of policy enactment. The federal government's threat to withhold transportation funds was associated with a 10.30 times greater hazard (HR: 10.30, 95% CI 3.88 to 27.36) of states adopting a 0.08 g/dL BAC law compared with periods of time when this threat was not in place. The incentive grant programme created by the federal government was associated with a non-significant 17% decrease in the hazard of states adopting a 0.08 g/dL BAC law (HR: 0.83, 95% CI 0.35 to 2.0). In the case of 0.08 g/dL BAC per se laws, the federal government's threat to withhold transportation funds was effective at accelerating policy adoption. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

The effects of the lower ignition propensity cigarettes standard in Estonia: time-series analysis.

PubMed

Saar, Indrek

2018-02-01

In 2011, the lower ignition propensity (LIP) standard for cigarettes was implemented in the European Union. Evidence about the impact of that safety measure is scarce. The aim of this paper is to examine the effects of the LIP standard on fire safety in Estonia. The absolute level of smoking-related fire incidents and related deaths was modelled using dynamic time-series regression analysis. The data about house fire incidents for the 2007-2013 period were obtained from the Estonian Rescue Board. Implementation of the LIP standard has reduced the monthly level of smoking-related fires by 6.2 (p<0.01, SE=1.95) incidents and by 26% (p<0.01, SE=9%) when estimated on the log scale. Slightly weaker evidence was found about the fatality reduction effects of the LIP regulation. All results were confirmed through counterfactual models for non-smoking-related fire incidents and deaths. This paper indicates that implementation of the LIP cigarettes standard has improved fire safety in Estonia. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Initial assessment of the intensity distribution of the 2011 Mw5.8 Mineral, Virginia, earthquake

USGS Publications Warehouse

Hough, Susan E.

2012-01-01

The intensity data collected by the U.S. Geological Survey (USGS) "Did You Feel It?" (DYFI) Website (USGS, DYFI; http://earthquake.usgs.gov/earthquakes/dyfi/events/se/082311a/us/index.html, last accessed Sept 2011) for the Mw5.8 Mineral, Virginia, earthquake, are unprecedented in their spatial richness and geographical extent. More than 133,000 responses were received during the first week following the earthquake. Although intensity data have traditionally been regarded as imprecise and generally suspect (e.g., Hough 2000), there is a growing appreciation for the potential utility of spatially rich, systematically determined DYFI data to address key questions in earthquake ground-motions science (Atkinson and Wald, 2007; Hauksson et al., 2008).

Freiburg RNA tools: a central online resource for RNA-focused research and teaching.

PubMed

Raden, Martin; Ali, Syed M; Alkhnbashi, Omer S; Busch, Anke; Costa, Fabrizio; Davis, Jason A; Eggenhofer, Florian; Gelhausen, Rick; Georg, Jens; Heyne, Steffen; Hiller, Michael; Kundu, Kousik; Kleinkauf, Robert; Lott, Steffen C; Mohamed, Mostafa M; Mattheis, Alexander; Miladi, Milad; Richter, Andreas S; Will, Sebastian; Wolff, Joachim; Wright, Patrick R; Backofen, Rolf

2018-05-21

The Freiburg RNA tools webserver is a well established online resource for RNA-focused research. It provides a unified user interface and comprehensive result visualization for efficient command line tools. The webserver includes RNA-RNA interaction prediction (IntaRNA, CopraRNA, metaMIR), sRNA homology search (GLASSgo), sequence-structure alignments (LocARNA, MARNA, CARNA, ExpaRNA), CRISPR repeat classification (CRISPRmap), sequence design (antaRNA, INFO-RNA, SECISDesign), structure aberration evaluation of point mutations (RaSE), and RNA/protein-family models visualization (CMV), and other methods. Open education resources offer interactive visualizations of RNA structure and RNA-RNA interaction prediction as well as basic and advanced sequence alignment algorithms. The services are freely available at http://rna.informatik.uni-freiburg.de.

Clinical laboratory sciences data transmission : the NPU coding system

PubMed Central

PONTET, Françoise; PETERSEN, Ulla MAGDAL; FUENTES-ARDERIU, Xavier; NORDIN, Gunnar; BRUUNSHUUS, Ivan; IHALAINEN, Jarkko; KARLSSON, Daniel; FORSUM, Urban; DYBKAER, René; SCHADOW, Gunther; KUELPMANN, Wolf; FÉRARD, Georges; KANG, Dongchon; McDONALD, Clement; HILL, Gilbert

2011-01-01

Introduction In health care services, technology requires that correct information be duly available to professionals, citizens and authorities, worldwide. Thus, clinical laboratory sciences require standardized electronic exchanges for results of laboratory examinations. Methods. The NPU (Nomenclature, Properties and Units) coding system provides a terminology for identification of result values (property values). It is structured according to BIPM, ISO, IUPAC and IFCC recommendations. It uses standard terms for established concepts and structured definitions describing: which part of the universe is examined, which component of relevance in that part, which kind-of-property is relevant. Unit and specifications can be added where relevant [System(spec) Component(spec); kind-of-property(spec) = ? unit]. Results. The English version of this terminology is freely accessible at http://dior.imt.liu.se/cnpu/ and http://www.labterm.dk, directly or through the IFCC and IUPAC websites. It has been nationally used for more than 10 years in Denmark and Sweden and has been translated into 6 other languages. Conclusions. The NPU coding system provides a terminology for dedicated kinds-of-property following the international recommendations. It fits well in the health network and is freely accessible. Clinical laboratory professionals worldwide will find many advantages in using the NPU coding system, notably with regards to an accreditation process. PMID:19745311

Capturing domain knowledge from multiple sources: the rare bone disorders use case.

PubMed

Groza, Tudor; Tudorache, Tania; Robinson, Peter N; Zankl, Andreas

2015-01-01

Lately, ontologies have become a fundamental building block in the process of formalising and storing complex biomedical information. The community-driven ontology curation process, however, ignores the possibility of multiple communities building, in parallel, conceptualisations of the same domain, and thus providing slightly different perspectives on the same knowledge. The individual nature of this effort leads to the need of a mechanism to enable us to create an overarching and comprehensive overview of the different perspectives on the domain knowledge. We introduce an approach that enables the loose integration of knowledge emerging from diverse sources under a single coherent interoperable resource. To accurately track the original knowledge statements, we record the provenance at very granular levels. We exemplify the approach in the rare bone disorders domain by proposing the Rare Bone Disorders Ontology (RBDO). Using RBDO, researchers are able to answer queries, such as: "What phenotypes describe a particular disorder and are common to all sources?" or to understand similarities between disorders based on divergent groupings (classifications) provided by the underlying sources. RBDO is available at http://purl.org/skeletome/rbdo. In order to support lightweight query and integration, the knowledge captured by RBDO has also been made available as a SPARQL Endpoint at http://bio-lark.org/se_skeldys.html.

Clinical laboratory sciences data transmission: the NPU coding system.

PubMed

Pontet, Françoise; Magdal Petersen, Ulla; Fuentes-Arderiu, Xavier; Nordin, Gunnar; Bruunshuus, Ivan; Ihalainen, Jarkko; Karlsson, Daniel; Forsum, Urban; Dybkaer, René; Schadow, Gunther; Kuelpmann, Wolf; Férard, Georges; Kang, Dongchon; McDonald, Clement; Hill, Gilbert

2009-01-01

In health care services, technology requires that correct information be duly available to professionals, citizens and authorities, worldwide. Thus, clinical laboratory sciences require standardized electronic exchanges for results of laboratory examinations. The NPU (Nomenclature, Properties and Units) coding system provides a terminology for identification of result values (property values). It is structured according to BIPM, ISO, IUPAC and IFCC recommendations. It uses standard terms for established concepts and structured definitions describing: which part of the universe is examined, which component of relevance in that part, which kind-of-property is relevant. Unit and specifications can be added where relevant [System(spec)-Component(spec); kind-of-property(spec) = ? unit]. The English version of this terminology is freely accessible at http://dior.imt.liu.se/cnpu/ and http://www.labterm.dk, directly or through the IFCC and IUPAC websites. It has been nationally used for more than 10 years in Denmark and Sweden and has been translated into 6 other languages. The NPU coding system provides a terminology for dedicated kinds-of-property following the international recommendations. It fits well in the health network and is freely accessible. Clinical laboratory professionals worldwide will find many advantages in using the NPU coding system, notably with regards to an accreditation process.

Identificação de variáveis cataclísmicas eruptivas na direção do bojo galáctico e Nuvens de Magalhães usando dados do OGLE

NASA Astrophysics Data System (ADS)

Cieslinski, D.; Diaz, M. P.; Mennickent, R.; Pietrzyski, G.

2003-08-01

Na década de 90 iniciaram-se vários programas para a pesquisa de matéria escura na Galáxia usando o efeito de microlentes gravitacionais. Entre os projetos mais bem conhecidos podemos mencionar o OGLE (Optical Gravitational Lensing Experiment) e o MACHO (MAssive Compact Halo Objects). A estratégia usada por eles consiste em fazer fotometria de banda larga (normalmente B, R e I) de um grande número de estrelas (dezenas de milhões) tão freqüentemente quanto possí vel e por longos perí odos de tempo (anos). Uma tal sistemática de observação, além de descobrir inúmeras lentes gravitacionais, é também muito apropriada para a descoberta de estrelas variáveis. De fato, inúmeras novas variáveis de vários tipos foram descobertas como subproduto. Exemplos podem ser encontrados nos endereços http://bulge.princeton.edu/~ogle/ e http://wwwmacho.mcmaster.ca/. As variáveis cataclí smicas eruptivas (novas clássicas, novas recorrentes e novas anãs) são objetos que apresentam variabilidade de grande amplitude com escalas de tempo de dias a centenas de dias e, por esta razão, devem ter sido detectadas em grande número nestes "surveys". Para testar esta possibilidade nós procuramos nos dados do OGLE por tais sistemas e o presente trabalho mostra os resultados desta pesquisa. Os objetos foram selecionados entre as variáveis detectadas usando a amplitude de variação de brilho como critério principal. Este critério forneceu 13756 objetos, sendo 2169 na direção da Grande Nuvem de Magalhães, 1162 na direção da Pequena Nuvem de Magalhães e o restante na direção do Bojo Galáctico. A análise foi feita inspecionando-se visualmente cada curva de luz por erupções com as características acima mencionadas. Os resultados obtidos podem ser sumarizados como: descoberta de duas novas clássicas e 33 novas anãs. Além disso, pode-se mencionar a identificação de candidatas a outros tipos de variáveis como: estrelas simbióticas, RV Tauri, R Coronae Borealis, Miras, etc.

The Effect of Doctor-Consumer Interaction on Social Media on Consumers' Health Behaviors: Cross-Sectional Study.

PubMed

Wu, Tailai; Deng, Zhaohua; Feng, Zhanchun; Gaskin, Darrell J; Zhang, Donglan; Wang, Ruoxi

2018-02-28

Both doctors and consumers have engaged in using social media for health purposes. Social media has changed traditional one-to-one communication between doctors and patients to many-to-many communication between doctors and consumers. However, little is known about the effect of doctor-consumer interaction on consumers' health behaviors. The aim of this study was to investigate how doctor-consumer interaction in social media affects consumers' health behaviors. On the basis of professional-client interaction theory and social cognitive theory, we propose that doctor-consumer interaction can be divided into instrumental interaction and affective interaction. These two types of interactions influence consumers' health behaviors through declarative knowledge (DK), self-efficacy (SE), and outcome expectancy (OE). To validate our proposed research model, we employed the survey method and developed corresponding measurement instruments for constructs in our research model. A total of 352 valid answers were collected, and partial least square was performed to analyze the data. Instrumental doctor-consumer interaction was found to influence consumers' DK (t 294 =5.763, P<.001), SE (t 294 =4.891, P<.001), and OE (t 294 =7.554, P<.001) significantly, whereas affective doctor-consumer interaction also impacted consumers' DK (t 294 =4.025, P<.001), SE (t 294 =4.775, P<.001), and OE (t 294 =4.855, P<.001). Meanwhile, consumers' DK (t 294 =3.838, P<.001), SE (t 294 =3.824, P<.001), and OE (t 294 =2.985, P<.01) all significantly affected consumers' health behaviors. Our mediation analysis showed that consumers' DK, SE, and OE partially mediated the effect of instrumental interaction on health behaviors, whereas the three mediators fully mediated the effect of affective interaction on health behaviors. Compared with many intentional intervention programs, doctor-consumer interaction can be treated as a natural cost-effective intervention to promote consumers' health behaviors. Meanwhile, both instrumental and affective interaction should be highlighted for the best interaction results. DK, SE, and OE are working mechanisms of doctor-consumer interaction. ©Tailai Wu, Zhaohua Deng, Zhanchun Feng, Darrell J Gaskin, Donglan Zhang, Ruoxi Wang. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 28.02.2018.

Physical incorporation of particles in a porous media: a path to a smart wood

NASA Astrophysics Data System (ADS)

Zerriaa, Azza; El Ganaoui, Mohammed; Gerardin, Christine; Tazibt, Abdel; Gabsi, Slimane

2016-05-01

The aim of this work is to develop a functional wood incorporating, in its surface, physical and chemical properties that meet society demand. For instance: fire resistance, magnetic electrical conduction (metal-wood particles), antibacterial reaction (copper-wood), anti-pollution (zeolite-wood), dry coloring, reflective effects (minerals-wood). As part of the research on wooden materials, the technique of "JAZOLTHOP1" driving micrometric particles before combining them and moving in supersonic speeds was used in the framework of enriching a wooden substrate. Various tests were conducted on two wooden materials (fir and ash tree) submitted to four typologies of particles (steel shot, garnet, corundum and glass beads). The surfaces of the test samples were machined beforehand for a use of conventional smooth quality, thus defining a reference surface before incorporation. The enriched samples were characterized by using two optical techniques; firstly a surface technique through macroscopy Leica 110X ZP, then a volume technique through tomography2. Subsequently, volume simulations (wood-inclusions) were implemented to study the thermal transfer. The obtained results showcase the existence of certain set conditions to reach the critical fluency of incorporation and to localize the enrichment on a parallel plan to the sample surface. The results show also the influence of particles concentration and the kind of the chosen wood on the final composite matrix/particle media. Contribution to the topical issue "Materials for Energy Harvesting, Conversion and Storage (ICOME 2015) - Elected submissions", edited by Jean-Michel Nunzi, Rachid Bennacer and Mohammed El Ganaoui http:// http:// http:// http:// http:// http://Nunzihttp:// http://Jean-Michelhttp:// http:// http:// http:// http:// http://Bennacerhttp:// http://Rachidhttp:// http:// http:// http:// http:// http://El Ganaouihttp:// http://Mohammedhttp:// http:// http:// http://Guest editorshttp:// http:// http:// http:// http:// http://Zerriaahttp:// http://Azzahttp:// http:// http://1http:// http://ahttp:// http:// http:// http:// http://El Ganaouihttp:// http://Mohammedhttp:// http:// http://1http:// http:// http:// http:// http://Gerardinhttp:// http://Christinehttp:// http:// http://2http:// http:// http:// http:// http://Tazibthttp:// http://Abdelhttp:// http:// http://3http:// http:// http:// http:// http://Gabsihttp:// http://Slimanehttp:// http:// http://4http:// http:// http:// http:// http:// http://Lorraine University, LERMAB-Longwy, IUT Henri Poincaré Longwyhttp://, http://186 rue de Lorrainehttp://, http://54400http:// http://Cosnes-et-Romainhttp://, http://Francehttp:// http:// http:// http:// http:// http://Lorraine University, LERMAB-Nancy, FST, rue des aiguilletteshttp://, http://54000http:// http://Nancyhttp://, http://Francehttp:// http:// http:// http:// http:// http://CRITT Techniques Jet Fluides et Usinagehttp://, http://55000http:// http://Bar-le-Duchttp://, http://Francehttp:// http:// http:// http:// http:// http://Unité de Recherche Environnement, Catalyse et Analyse Des Procédés, Ecole nationale d'ingénieurs de Gabeshttp://, http://Tunisiehttp:// http:// http:// http:// http:// e-mail: azza.zerriaa@univ-lorraine.fr http:// http://http://http://03http://http://05http://http://2016http://http:// http:// http://05http:// http://2016http:// http:// http:// http://03http:// http://05http:// http://2016http:// http://http:// http://03http:// http://05http:// http://2016http:// http:// http://74http:// http://2http://http://epjap/2016/05http:// http://Materials for Energy Harvesting, Conversion and Storage (ICOME 2015)http://http://24607http:// http:// http:// http://03http:// http://09http:// http://2015http:// http:// http:// http://18http:// http://09http:// http://2015http:// http:// http:// http://18http:// http://11http:// http://2015http:// http:// http:// http:// http://EDP Sciences, 2016http:// http://2016http:// http://EDP Scienceshttp:// http:// http:// http://The aim of this work is to develop a functional wood incorporating, in its surface, physical and chemical properties that meet society demand. For instance: fire resistance, magnetic electrical conduction (metal-wood particles), antibacterial reaction (copper-wood), anti-pollution (zeolite-wood), dry coloring, reflective effects (minerals-wood). As part of the research on wooden materials, the technique of "JAZOLTHOPhttp://1http://" driving micrometric particles before combining them and moving in supersonic speeds was used in the framework of enriching a wooden substrate. Various tests were conducted on two wooden materials (fir and ash tree) submitted to four typologies of particles (steel shot, garnet, corundum and glass beads). The surfaces of the test samples were machined beforehand for a use of conventional smooth quality, thus defining a reference surface before incorporation. The enriched samples were characterized by using two optical techniques; firstly a surface technique through macroscopy Leica 110X ZP, then a volume technique through tomographyhttp://2http://. Subsequently, volume simulations (wood-inclusions) were implemented to study the thermal transfer. The obtained results showcase the existence of certain set conditions to reach the critical fluency of incorporation and to localize the enrichment on a parallel plan to the sample surface. The results show also the influence of particles concentration and the kind of the chosen wood on the final composite matrix/particle media. http:// http:// http:// http:// http:// http:// http:// http:// http:// http:// http://idlinehttp:// http://Eur. Phys. J. Appl. Phys. (2016) 74: 24607http:// http:// http:// http://cover_datehttp:// http://May 2016http:// http:// http:// http://first_monthhttp:// http://05http:// http:// http:// http://last_monthhttp:// http://05http:// http:// http:// http://first_yearhttp:// http://2016http:// http:// http:// http://last_yearhttp:// http://2016http:// http:// http:// http:// http:// http:// http://CRITT-TJFUENS CACHAN facilities

Masculine discrepancy stress, substance use, assault and injury in a survey of US men.

PubMed

Reidy, Dennis E; Berke, Danielle S; Gentile, Brittany; Zeichner, Amos

2016-10-01

To understand and ultimately prevent injury and behavioural health outcomes associated with masculinity, we assessed the influence of masculine discrepancy stress (stress that occurs when men perceive themselves as falling short of the traditional gender norms) on the propensity to engage in stereotypically masculine behaviours (eg, substance use, risk taking and violence) as a means of demonstrating masculinity. Six-hundred men from the USA were recruited via Amazon's Mechanical Turk (MTurk) online data collection site to complete surveys assessing self-perceptions of gender role discrepancy and consequent discrepancy stress, substance use/abuse, driving while intoxicated (DWI) and violent assaults. Negative binomial regression analyses indicated significant interactive effects wherein men high on gender role discrepancy and attendant discrepancy stress reported significantly more assaults with a weapon (B=1.01; SE=0.63; IRR=2.74; p=0.05) and assaults causing injury (B=1.01; SE=0.51; IRR=2.74; p<0.05). There was no association of discrepancy stress to substance abuse, but there was a protective effect of gender role discrepancy for DWI among men low on discrepancy stress (B=-1.19, SE=0.48; IRR=0.30; p=0.01). These findings suggest that gender role discrepancy and associated discrepancy stress, in particular, represent important injury risk factors and that prevention of discrepancy stress may prevent acts of violence with the greatest consequences and costs to the victim, offender and society. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Siderophile-element Anomalies in CK Carbonaceous Chondrites: Implications for Parent-body Aqueous Alteration and Terrestrial Weathering of Sulfides

NASA Technical Reports Server (NTRS)

Huber, Heinz; Rubin, Alan E.; Kallemeyn, Gregory W.; Wasson, John T.

2006-01-01

CK chondrites constitute the most oxidized anhydrous carbonaceous chondrite group; most of the Fe occurs in magnetite and in FeO-rich mafic silicates. The two observed CK falls (Karoonda and Kobe), along with thirteen relatively unweathered CK finds, have unfractionated siderophile-element abundance patterns. In contrast, a sizable fraction of CK finds (9 of 24 investigated) shows fractionated siderophile abundance patterns including low abundances of Ni, Co, Se and Au; the most extreme depletions are in Ni (0.24 of normal CK) and Au (0.14 of normal CK). This depletion pattern has not been found in other chondrite groups. Out of the 74 CK chondrites listed in the Meteoritical Bulletin Database (2006; excluded considerably paired specimens; see http://tin.er.usgs.gov/meteor/ metbull.php) we analyzed 24 and subclassified the CK chondrites in terms of their chemical composition and sulfide mineralogy: sL (siderophiles low; six samples) for large depletions in Ni, Co, Se and Au (>50% of sulfides lost); sM (siderophiles medium; two CKs) for moderately low Ni and Co abundances (sulfides are highly altered or partly lost); sH (siderophiles high; one specimen) for enrichments in Ni, Co, Se and Au; 'normal' for unfractionated samples (13 samples). The sole sH sample may have obtained additional sulfide from impact redistribution in the parent asteroid. We infer that these elements became incorporated into sulfides after asteroidal aqueous processes oxidized nebular metal; thermal metamorphism probably also played a role in their mineral siting. The siderophile losses in the SL and sM samples are mainly the result of oxidation of pentlandite, pyrite and violarite by terrestrial alteration followed by leaching of the resulting phases. Some Antarctic CK chondrites have lost most of their sulfides but retained Ni, Co, Se and Au, presumably as insoluble weathering products.

Real-time patterns of smoking and alcohol use: an observational study protocol of risky-drinking smokers.

PubMed

Cohn, Amy; Brandon, Thomas; Armeli, Stephen; Ehlke, Sarah; Bowers, Molly

2015-01-06

Despite the strong relationship between smoking and health-related consequences, very few smokers quit. Heavy drinking is a significant risk factor for health consequences, and is implicated in persistent smoking and less success at quitting smoking. Self-efficacy (SE) to abstain from smoking is an important determinant of smoking outcomes and may link alcohol use to poor quit rates. Even though research has demonstrated a strong association between drinking and smoking, and the multiplicative effect of these substances on cancer-related, heavy-drinking smokers has been largely ignored in the literature. Further, research has not taken advantage of innovative methods, such as ecological momentary assessment, to capture the impact of daily factors on smoking cessation outcomes in this particular group. The proposed study identifies daily changing factors that impede or promote SE and future smoking cessation efforts in risky-drinking smokers. This is an observational study of 84 regular smokers (≥10 cigarettes per day) who drink at risky levels, report a desire to quit in the next 6 months, and show no evidence of psychiatric disturbance, severe history of alcohol withdrawal or drug dependence (excluding nicotine and caffeine). Participants report on their smoking, alcohol consumption and SE related to smoking twice a day for 28 days using interactive voice response (IVR) surveys. Multilevel regression and path models will examine within-person daily associations among drinking, smoking and SE, and how these variables predict the likelihood of future smoking behaviour at 1 and 6 months follow-up. This protocol was approved by an accredited Institutional Review Board. The findings will help us understand the factors that promote or impede smoking cessation among a high-risk group of smokers (heavy-drinking smokers) and will be disseminated through peer-reviewed journal articles and presentations at national conferences. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PconsD: ultra rapid, accurate model quality assessment for protein structure prediction.

PubMed

Skwark, Marcin J; Elofsson, Arne

2013-07-15

Clustering methods are often needed for accurately assessing the quality of modeled protein structures. Recent blind evaluation of quality assessment methods in CASP10 showed that there is little difference between many different methods as far as ranking models and selecting best model are concerned. When comparing many models, the computational cost of the model comparison can become significant. Here, we present PconsD, a fast, stream-computing method for distance-driven model quality assessment that runs on consumer hardware. PconsD is at least one order of magnitude faster than other methods of comparable accuracy. The source code for PconsD is freely available at http://d.pcons.net/. Supplementary benchmarking data are also available there. arne@bioinfo.se Supplementary data are available at Bioinformatics online.

Perils of Neglecting Lattice Relaxation in the Pressure Dependence of Deep Luminescence Bands in Wide Gap Semiconductors

NASA Astrophysics Data System (ADS)

Iota, V.; Weinstein, B. A.

1998-03-01

Deep defect states are often assumed to be insensitive to pressure because of their localized atomic-like character. In apparent conflict with this, experiments on widegap II-VI materials find that the pressure shifts of many 'midgap' photoluminescence (PL) bands associated with large-lattice-relaxation defects are more rapid than the shift of the bandgap(B. Weinstein, T. Ritter, et. al., Phys. Stat. Sol. (b) 198), 167 (1996). To study this, we measured the effects of pressure on the PL and PL-excitation (PLE) bands arising from the Zn-vacancy (V_Zn) and the P_Se deep acceptor centers in ZnSe. Using the observed pressure variation of the Stokes shifts and the established 1 atm. configuration coordinate (CC) models( D.Y. Jeon, H.P Gislason, G.D. Watkins, Phys. Rev. B 48), 7872 (1993), we were able to infer quantitative CC-diagrams at any pressure. Our results show that the pressure dependence of the lattice relaxation contributes a substantial fraction (several meV/kbar) to the overall shift of the PL-bands, and, hence, must be included. For the case of the V_Zn, simple calculations of the Jahn-Teller splitting using dangling-bond orbitals support this conclusion. figures

Using Real-Time Social Media Technologies to Monitor Levels of Perceived Stress and Emotional State in College Students: A Web-Based Questionnaire Study.

PubMed

Liu, Sam; Zhu, Miaoqi; Yu, Dong Jin; Rasin, Alexander; Young, Sean D

2017-01-10

College can be stressful for many freshmen as they cope with a variety of stressors. Excess stress can negatively affect both psychological and physical health. Thus, there is a need to find innovative and cost-effective strategies to help identify students experiencing high levels of stress to receive appropriate treatment. Social media use has been rapidly growing, and recent studies have reported that data from these technologies can be used for public health surveillance. Currently, no studies have examined whether Twitter data can be used to monitor stress level and emotional state among college students. The primary objective of our study was to investigate whether students' perceived levels of stress were associated with the sentiment and emotions of their tweets. The secondary objective was to explore whether students' emotional state was associated with the sentiment and emotions of their tweets. We recruited 181 first-year freshman students aged 18-20 years at University of California, Los Angeles. All participants were asked to complete a questionnaire that assessed their demographic characteristics, levels of stress, and emotional state for the last 7 days. All questionnaires were completed within a 48-hour period. All tweets posted by the participants from that week (November 2 to 8, 2015) were mined and manually categorized based on their sentiment (positive, negative, neutral) and emotion (anger, fear, love, happiness) expressed. Ordinal regressions were used to assess whether weekly levels of stress and emotional states were associated with the percentage of positive, neutral, negative, anger, fear, love, or happiness tweets. A total of 121 participants completed the survey and were included in our analysis. A total of 1879 tweets were analyzed. A higher level of weekly stress was significantly associated with a greater percentage of negative sentiment tweets (beta=1.7, SE 0.7; P=.02) and tweets containing emotions of fear (beta=2.4, SE 0.9; P=.01) and love (beta=3.6, SE 1.4; P=.01). A greater level of anger was negatively associated with the percentage of positive sentiment (beta=-1.6, SE 0.8; P=.05) and tweets related to the emotions of happiness (beta=-2.2, SE 0.9; P=.02). A greater level of fear was positively associated with the percentage of negative sentiment (beta=1.67, SE 0.7; P=.01), particularly a greater proportion of tweets related to the emotion of fear (beta=2.4, SE 0.8; P=.01). Participants who reported a greater level of love showed a smaller percentage of negative sentiment tweets (beta=-1.3, SE 0.7; P=0.05). Emotions of happiness were positively associated with the percentage of tweets related to the emotion of happiness (beta=-1.8, SE 0.8; P=.02) and negatively associated with percentage of negative sentiment tweets (beta=-1.7, SE 0.7; P=.02) and tweets related to the emotion of fear (beta=-2.8, SE 0.8; P=.01). Sentiment and emotions expressed in the tweets have the potential to provide real-time monitoring of stress level and emotional well-being in college students. ©Sam Liu, Miaoqi Zhu, Dong Jin Yu, Alexander Rasin, Sean D Young. Originally published in JMIR Mental Health (http://mental.jmir.org), 10.01.2017.

Vertical profiling of aerosol particles and trace gases over the central Arctic Ocean during summer

NASA Astrophysics Data System (ADS)

Kupiszewski, P.; Leck, C.; Tjernström, M.; Sjogren, S.; Sedlar, J.; Graus, M.; Müller, M.; Brooks, B.; Swietlicki, E.; Norris, S.; Hansel, A.

2013-04-01

Unique measurements of vertical size resolved aerosol particle concentrations, trace gas concentrations and meteorological data were obtained during the Arctic Summer Cloud Ocean Study (ASCOS, http://www.ascos.se), an International Polar Year project aimed at establishing the processes responsible for formation and evolution of low-level clouds over the high Arctic summer pack ice. The experiment was conducted from onboard the Swedish icebreaker Oden, and provided both ship- and helicopter-based measurements. This study focuses on the vertical helicopter profiles and onboard measurements obtained during a three-week period when Oden was anchored to a drifting ice floe, and sheds light on the characteristics of Arctic aerosol particles and their distribution throughout the lower atmosphere. Distinct differences in aerosol particle characteristics within defined atmospheric layers are identified. Near the surface (lowermost couple hundred meters), transport from the marginal ice zone (MIZ), if sufficiently short (less than ca. 2 days), condensational growth and cloud-processing develop the aerosol population. During two of the four representative periods defined in this study, such influence is shown. At altitudes above about 1 km, long-range transport occurs frequently. However, only infrequently does large-scale subsidence descend such air masses to become entrained into the mixed layer in the high Arctic, and therefore they are unlikely to directly influence low-level stratiform cloud formation. Nonetheless, long-range transport plumes can influence the radiative balance of the PBL by influencing formation and evolution of higher clouds, as well as through precipitation transport of particles downwards. New particle formation was occasionally observed, particularly in the near-surface layer. We hypothesize that the origin of these ultrafine particles can be from biological processes, both primary and secondary, within the open leads between the pack ice and/or along the MIZ. In general, local sources, in combination with upstream boundary layer transport of precursor gases from the MIZ, are suggested to constitute the origin of CCN particles and thus be of importance for the formation of interior Arctic low level clouds during summer, and subsequently, through cloud influences, on the melting and freezing of sea ice.

Executive Functioning in Alcoholics Following an mHealth Cognitive Stimulation Program: Randomized Controlled Trial

PubMed Central

Oliveira, Jorge; Lopes, Paulo; Brito, Rodrigo; Morais, Diogo; Silva, Diana; Silva, Ana; Rebelo, Sara; Bastos, Marta; Deus, Alberto

2014-01-01

Background The consequences of alcohol dependence are severe and may range from physical disease to neuropsychological deficits in several cognitive domains. Alcohol abuse has also been related to brain dysfunction specifically in the prefrontal cortex. Conventional neuropsychological interventions (paper-and-pencil cognitive stimulation training) have a positive effect but are time-consuming, costly, and not motivating for patients. Objective Our goal was to test the cognitive effects of a novel approach to neuropsychological intervention, using mobile technology and serious games, on patients with alcohol dependence. Methods The trial design consisted of a two-arm study assessing the cognitive outcomes of neuropsychological intervention with mobile serious games (mHealth) versus control (treatment-as-usual with no neuropsychological intervention) in patients undergoing treatment for alcohol dependence syndrome. Sixty-eight patients were recruited from an alcohol-rehab clinic and randomly assigned to the mHealth (n=33) or control condition (n=35). The intervention on the experimental group consisted of a therapist-assisted cognitive stimulation therapy for 4 weeks on a 2-3 days/week basis. Results Fourteen patients dropped out of the study. The results of the neuropsychological assessments with the remaining 54 patients showed an overall increase (P<.05) of general cognitive abilities, mental flexibility, psychomotor processing speed, and attentional ability in both experimental (n=26) and control groups (n=28). However, there was a more pronounced improvement (P=.01) specifically in frontal lobe functions from baseline (mean 13.89, SE 0.58) to follow-up (mean 15.50, SE 0.46) in the experimental group but not in the control group. Conclusions The overall increase in general cognitive function for both experimental and control groups supports the beneficial role of existing alcohol treatment protocols aimed at minimizing withdrawal symptoms, but the differential improvements observed in frontal lobe functioning supports the use of mobile serious games for neuropsychological stimulation to overcome executive dysfunction in patients with alcohol dependence. This trial was negative on two neuropsychological/cognitive tests, and positive on one. Trial Registration ClinicalTrials.gov NCT01942954; http://www.clinicaltrials.gov/ct2/show/NCT01942954 (Archived by WebCite at http://www.webcitation.org/6OYDqHLwB). PMID:24742381

An exploratory study of illegal gamblers in Hong Kong.

PubMed

Tessler, Andrew; El Beyrouty, Kareen; Crapnell, Natasha

2017-01-01

This study investigates the nature and behaviour of illegal gamblers in Hong Kong. A face-to-face street survey of 512 gamblers was conducted in Hong Kong between September and December 2015 with supplementary convenience sampling allowing for analysis of a total sample of 103 illegal gamblers. 56% of illegal gamblers recorded results consistent with this study's definition of 'excessive gambling' [i.e. moderate risk and problem gamblers under the Problem Gambling Severity Index (PGSI)]. 81% of surveyed illegal gamblers were male, 77% were aged between 30 and 49 and 67% were in blue collar occupations. Illegal gamblers bet more frequently on both legal and illegal games than their legal counterparts and spent more when they did bet. While this research did not indicate the direction of causality between illegal and excessive gambling, international work (de Bruin et al. in verslingerd aan meer dan een spel: Een onderzoek naar de aard en omvang van kansspelproblematiek in Nederland, WODC/CVO, Utrecht, http://www.lexandgaming.eu/nl/wp-content/uploads/2015/01/Verslingerd-aan-meer-dan-een-spel.pdf, 2005; Binde in What are the most harmful forms of gambling? Analysing problem gambling prevalence surveys, http://www.utbildning.gu.se/digitalAssets/1327/1327132_cefos-wp12.pdf, 2011) suggests that excessive gamblers are drawn to illegal gambling. Reform could allow excessive gambling by illegal gamblers to be better addressed and initial work suggests some financial benefits to Hong Kong.

NMR Evidences of the Coupling between Conduction Electrons and Molecular Degrees of Freedom in the Exotic Member of the Bechgaard Salt (TMTSF)2FSO3

NASA Astrophysics Data System (ADS)

Satsukawa, Hidetaka; Yajima, Akio; Hiraki, Ko-ichi; Takahashi, Toshihiro; Kang, Haeyong; Jo, Younjung; Kang, Woun; Chung, Ok-Hee

2016-12-01

We performed 77Se- and 19F-NMR measurements on single crystals of (TMTSF)2FSO3 to characterize the electronic structures of different phases in the temperature-pressure phase diagram, determined by precise transport measurements [Jo et al., Phys. Rev. B 67, 014516 (2003)]. We claim that such varieties of electronic states in the refined phase diagram are caused by strong couplings of the conduction electrons with FSO3 anions, especially with the permanent electric dipoles on the anions. We suggest that as temperature decreases, the FSO3 anions form orientational ordering through two steps; first, only the tetrahedrons form an orientational order leaving the orientations of the electronic dipoles in random (transition I); then the dipoles form a perfect orientational order at a lower temperature (transition II). In the intermediate temperature range between transitions I and II, we found an appreciable enhancement of homogeneous and inhomogeneous widths of the 77Se-NMR spectrum. From the analysis of the angular dependence of the linewidth, we attributed these anomalies to the intramolecular charge disproportionation or imbalance and its slow dynamics caused by the coupling with the permanent electric dipole of the anion. Results of 19F-NMR relaxation and lineshape measurements support this picture very well. Electronic structures at higher pressures up to 1.25 GPa are discussed on the basis of the results of the 77Se- and 19F-NMR measurements.

Application of a three-dimensional hydrodynamic model to the Himmerfjärden, Baltic Sea

NASA Astrophysics Data System (ADS)

Sokolov, Alexander

2014-05-01

Himmerfjärden is a coastal fjord-like bay situated in the north-western part of the Baltic Sea. The fjord has a mean depth of 17 m and a maximum depth of 52 m. The water is brackish (6 psu) with small salinity fluctuation (±2 psu). A sewage treatment plant, which serves about 300 000 people, discharges into the inner part of Himmerfjärden. This area is the subject of a long-term monitoring program. We are planning to develop a publicly available modelling system for this area, which will perform short-term forecast predictions of pertinent parameters (e.g., water-levels, currents, salinity, temperature) and disseminate them to users. A key component of the system is a three-dimensional hydrodynamic model. The open source Delft3D Flow system (http://www.deltaressystems.com/hydro) has been applied to model the Himmerfjärden area. Two different curvilinear grids were used to approximate the modelling domain (25 km × 50 km × 60 m). One grid has low horizontal resolution (cell size varies from 250 to 450 m) to perform long-term numerical experiments (modelling period of several months), while another grid has higher resolution (cell size varies from 120 to 250 m) to model short-term situations. In vertical direction both z-level (50 layers) and sigma coordinate (20 layers) were used. Modelling results obtained with different horizontal resolution and vertical discretisation will be presented. This model will be a part of the operational system which provides automated integration of data streams from several information sources: meteorological forecast based on the HIRLAM model from the Finnish Meteorological Institute (https://en.ilmatieteenlaitos.fi/open-data), oceanographic forecast based on the HIROMB-BOOS Model developed within the Baltic community and provided by the MyOcean Project (http://www.myocean.eu), riverine discharge from the HYPE model provided by the Swedish Meteorological Hydrological Institute (http://vattenwebb.smhi.se/modelarea/).

Trends in suicidal behaviour in Dutch general practice 1983-2013: a retrospective observational study.

PubMed

de Beurs, Derek P; Hooiveld, Mariette; Kerkhof, Ad J F M; Korevaar, Joke C; Donker, Gé A

2016-05-10

To analyse trends in suicidal behaviour as reported by the Dutch sentinel general practices from 1983 to 2013. Second, to examine the relationship between suicidal behaviour and several patient characteristics. Finally, to compare the relationship between suicidal behaviour and patient characteristics before (1983-2007) and after (2008-2013) the start of the crisis. 40 general practices in the Netherlands during the period 1983-2013. Patients with an ICPC code of P77 (suicide attempt). Primary outcomes were age-adjusted and gender-specific trends in reported suicides (342) and suicide attempts (1614). Secondary outcomes were the relationship between suicidal behaviour and age, household composition, history of depression, recognition of suicide ideation, treatment before the suicidal behaviour and contact within the past month before suicidal behaviour for the period 1983-2013. Additionally, separate frequencies for the periods 1983-2007 and 2008-2013 were presented. Join-point analyses revealed a significant rise in male suicides from 2008 (b=0.32, SE=0.1, p=0.008), and an increase in male suicide attempts since 2009 (b=0.19, SE=0.04, p<0.001). Female suicidal behaviour showed a steady decrease from 1989 to 2013(b=-0.03, SE=0.007, p<0.0001 for female suicide, b=-0.02, SE=0.002, p<0.001 for female attempts). Before 2007, a history of depression was reported in 65% (168/257) of the suicides. After the start of the recession, a depression was recognised in 44% (22/50) of the patients who died by suicide. Since 2008, there was a rise in the male suicide rate while female suicide behaviour has continued to decline. General practitioners less often reported a history of depression within patients who died due to suicide after 2007 than before. Training in the early recognition of suicide ideation in depressive patients might improve suicide prevention in primary care. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Creating a Partnering Community Aimed to Foster Climate Literacy in the Southeastern United States

NASA Astrophysics Data System (ADS)

Rutherford, D.; McNeal, K. S.; Smith, R.; Hare, D.; Nair, U. S.

2011-12-01

The Climate Literacy Partnership in the Southeast (CLiPSE) is a part of the Climate Change Education Program supported by the National Science Foundation (http://CLiPSE-project.org). The established CLiPSE partnership is dedicated to improving climate literacy in the southeast through crafting a shared vision and strategic plan among stakeholders that promotes scientific formal and informal educational resources, materials and programs; a diverse network of key partnering organizations throughout the Southeastern United States (SE US); and effective public dialogues that address diverse learners and audiences and supports learning of climate, climate change, and its relevance upon human and environmental systems. The CLiPSE project has been successful in creating partnerships with more than fifty key stakeholders that stem from a few key publics such as agriculture, education, leisure, religious organizations, and culturally diverse communities. These key publics in the SE US frequently consist of individuals that place great trust in local, private efforts, and CLiPSE has realized the importance of the role of the partnering organizations in providing information through a trusted source. A second unique characteristic of the SE US is the predominately conservative and Protestant citizenry in the region. Working with and through these communities enhances climate change education outreach to this citizenry. The CLiPSE project rests on solid climate science and learning science research in order to formulate an effective plan with desired learning outcomes of critical thinking and civil conversation through effective communication strategies. This paper will present the CLiPSE model in reaching the key publics that traditionally hold ideologies that are traditionally perceived as incompatible with climate change science. We will present the strategies utilized to bring together experts and researchers in climate science, learning science, and social science with practitioners and leaders of key stakeholder groups to formulate a shared climate change education plan in the SE US that is uniquely formatted for each target audience. We will also share what we have learned from interacting with the leaders of our partnering organizations in crafting effective messages for their audiences and addressing learners' affective and cognitive domains.

"Stop, You're Killing us!" An Alternative Take on Populism and Public Health Comment on "The Rise of Post-truth Populism in Pluralist Liberal Democracies: Challenges for Health Policy".

PubMed

Schrecker, Ted

2017-04-26

Ewen Speed and Russell Mannion correctly identify several contours of the challenges for health policy in what it is useful to think of as a post-democratic era. I argue that the problem for public health is not populism per se, but rather the distinctive populism of the right coupled with the failure of the left to develop compelling counternarratives. Further, defences of 'science' must be tempered by recognition of the unavoidably political dimensions of the (mis)use of scientific findings in public policy. © 2017 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Motif discovery and motif finding from genome-mapped DNase footprint data.

PubMed

Kulakovskiy, Ivan V; Favorov, Alexander V; Makeev, Vsevolod J

2009-09-15

Footprint data is an important source of information on transcription factor recognition motifs. However, a footprinting fragment can contain no sequences similar to known protein recognition sites. Inspection of genome fragments nearby can help to identify missing site positions. Genome fragments containing footprints were supplied to a pipeline that constructed a position weight matrix (PWM) for different motif lengths and selected the optimal PWM. Fragments were aligned with the SeSiMCMC sampler and a new heuristic algorithm, Bigfoot. Footprints with missing hits were found for approximately 50% of factors. Adding only 2 bp on both sides of a footprinting fragment recovered most hits. We automatically constructed motifs for 41 Drosophila factors. New motifs can recognize footprints with a greater sensitivity at the same false positive rate than existing models. Also we discuss possible overfitting of constructed motifs. Software and the collection of regulatory motifs are freely available at http://line.imb.ac.ru/DMMPMM.

Ground-based multi-station spectroscopic imaging with ALIS. - Scientific highlights, project status and future prospects

NASA Astrophysics Data System (ADS)

Brändström; Gustavsson, Björn; Pellinen-Wannberg, Asta; Sandahl, Ingrid; Sergienko, Tima; Steen, Ake

2005-08-01

The Auroral Large Imaging System (ALIS) was first proposed at the ESA-PAC meeting in Lahnstein 1989. The first spectroscopic imaging station was operational in 1994, and since then up to six stations have been in simultaneous operation. Each station has a scientific-grade CCD-detector and a filter-wheel for narrow-band interference-filters with six positions. The field-of-view is around 70°. Each imager is mounted in a positioning system, enabling imaging of a common volume from several sites. This enables triangulation and tomography. Raw data from ALIS is freely available at ("http://alis.irf.se") and ALIS is open for scientific colaboration. ALIS made the first unambiguous observations of Radio-induced optical emissions at high latitudes, and the detection of water in a Leonid meteor-trail. Both rockets and satellite coordination are considered for future observations with ALIS.

IsoCor: correcting MS data in isotope labeling experiments.

PubMed

Millard, Pierre; Letisse, Fabien; Sokol, Serguei; Portais, Jean-Charles

2012-05-01

Mass spectrometry (MS) is widely used for isotopic labeling studies of metabolism and other biological processes. Quantitative applications-e.g. metabolic flux analysis-require tools to correct the raw MS data for the contribution of all naturally abundant isotopes. IsoCor is a software that allows such correction to be applied to any chemical species. Hence it can be used to exploit any isotopic tracer, from well-known ((13)C, (15)N, (18)O, etc) to unusual ((57)Fe, (77)Se, etc) isotopes. It also provides new features-e.g. correction for the isotopic purity of the tracer-to improve the accuracy of quantitative isotopic studies, and implements an efficient algorithm to process large datasets. Its user-friendly interface makes isotope labeling experiments more accessible to a wider biological community. IsoCor is distributed under OpenSource license at http://metasys.insa-toulouse.fr/software/isocor/

Foggy perception slows us down.

PubMed

Pretto, Paolo; Bresciani, Jean-Pierre; Rainer, Gregor; Bülthoff, Heinrich H

2012-10-30

Visual speed is believed to be underestimated at low contrast, which has been proposed as an explanation of excessive driving speed in fog. Combining psychophysics measurements and driving simulation, we confirm that speed is underestimated when contrast is reduced uniformly for all objects of the visual scene independently of their distance from the viewer. However, we show that when contrast is reduced more for distant objects, as is the case in real fog, visual speed is actually overestimated, prompting drivers to decelerate. Using an artificial anti-fog-that is, fog characterized by better visibility for distant than for close objects, we demonstrate for the first time that perceived speed depends on the spatial distribution of contrast over the visual scene rather than the global level of contrast per se. Our results cast new light on how reduced visibility conditions affect perceived speed, providing important insight into the human visual system.DOI:http://dx.doi.org/10.7554/eLife.00031.001.

Tropical Depression Debbie in the Atlantic

NASA Image and Video Library

2006-08-22

These images show Tropical Depression Debbie in the Atlantic, from the Atmospheric Infrared Sounder (AIRS) on NASA's Aqua satellite on August 22, 2006. This AIRS image shows the temperature of the cloud tops or the surface of the Earth in cloud-free regions. The lowest temperatures (in purple) are associated with high, cold cloud tops that make up the top of the storm. The infrared signal does not penetrate through clouds. Where there are no clouds the AIRS instrument reads the infrared signal from the surface of the Earth, revealing warmer temperatures (red). At the time the data were taken from which these images were made the eye had not yet opened but the storm is now well organized. The location of the future eye appears as a circle at 275 K brightness temperature in the microwave image just to the SE of the Azores. http://photojournal.jpl.nasa.gov/catalog/PIA00508

Information-computational system for storage, search and analytical processing of environmental datasets based on the Semantic Web technologies

NASA Astrophysics Data System (ADS)

Titov, A.; Gordov, E.; Okladnikov, I.

2009-04-01

In this report the results of the work devoted to the development of working model of the software system for storage, semantically-enabled search and retrieval along with processing and visualization of environmental datasets containing results of meteorological and air pollution observations and mathematical climate modeling are presented. Specially designed metadata standard for machine-readable description of datasets related to meteorology, climate and atmospheric pollution transport domains is introduced as one of the key system components. To provide semantic interoperability the Resource Description Framework (RDF, http://www.w3.org/RDF/) technology means have been chosen for metadata description model realization in the form of RDF Schema. The final version of the RDF Schema is implemented on the base of widely used standards, such as Dublin Core Metadata Element Set (http://dublincore.org/), Directory Interchange Format (DIF, http://gcmd.gsfc.nasa.gov/User/difguide/difman.html), ISO 19139, etc. At present the system is available as a Web server (http://climate.risks.scert.ru/metadatabase/) based on the web-portal ATMOS engine [1] and is implementing dataset management functionality including SeRQL-based semantic search as well as statistical analysis and visualization of selected data archives [2,3]. The core of the system is Apache web server in conjunction with Tomcat Java Servlet Container (http://jakarta.apache.org/tomcat/) and Sesame Server (http://www.openrdf.org/) used as a database for RDF and RDF Schema. At present statistical analysis of meteorological and climatic data with subsequent visualization of results is implemented for such datasets as NCEP/NCAR Reanalysis, Reanalysis NCEP/DOE AMIP II, JMA/CRIEPI JRA-25, ECMWF ERA-40 and local measurements obtained from meteorological stations on the territory of Russia. This functionality is aimed primarily at finding of main characteristics of regional climate dynamics. The proposed system represents a step in the process of development of a distributed collaborative information-computational environment to support multidisciplinary investigations of Earth regional environment [4]. Partial support of this work by SB RAS Integration Project 34, SB RAS Basic Program Project 4.5.2.2, APN Project CBA2007-08NSY and FP6 Enviro-RISKS project (INCO-CT-2004-013427) is acknowledged. References 1. E.P. Gordov, V.N. Lykosov, and A.Z. Fazliev. Web portal on environmental sciences "ATMOS" // Advances in Geosciences. 2006. Vol. 8. p. 33 - 38. 2. Gordov E.P., Okladnikov I.G., Titov A.G. Development of elements of web based information-computational system supporting regional environment processes investigations // Journal of Computational Technologies, Vol. 12, Special Issue #3, 2007, pp. 20 - 28. 3. Okladnikov I.G., Titov A.G. Melnikova V.N., Shulgina T.M. Web-system for processing and visualization of meteorological and climatic data // Journal of Computational Technologies, Vol. 13, Special Issue #3, 2008, pp. 64 - 69. 4. Gordov E.P., Lykosov V.N. Development of information-computational infrastructure for integrated study of Siberia environment // Journal of Computational Technologies, Vol. 12, Special Issue #2, 2007, pp. 19 - 30.

Anesthesia Basics

MedlinePlus

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Asthma Diary

MedlinePlus

... FrameworkServlet.doGet(FrameworkServlet.java:549) at javax.servlet.http.HttpServlet.service(HttpServlet.java:617) at javax.servlet.http.HttpServlet.service(HttpServlet.java:717) at org.apache. ...

Cardiac Catheterization (For Teens)

MedlinePlus

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Senses and Your 8- to 12-Month-Old

MedlinePlus

... FrameworkServlet.doGet(FrameworkServlet.java:549) at javax.servlet.http.HttpServlet.service(HttpServlet.java:617) at javax.servlet.http.HttpServlet.service(HttpServlet.java:717) at org.apache. ...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tomopy is a Python toolbox to perform x-ray data processing, image reconstruction and data exchange tasks at synchrotron facilities. The dependencies of the software are currently as follows: -Python related python standard library (http://docs.python.org/2/library/) numpy (http://www.numpy.org/) scipy (http://scipy.org/) matplotlib (http://matplotlip.org/) sphinx (http://sphinx-doc.org) pil (http://www.pythonware.com/products/pil/) pyhdf (http://pysclint.sourceforge.net/pyhdf/) h5py (http://www.h5py.org) pywt (http://www.pybytes.com/pywavelets/) file.py (https://pyspec.svn.sourceforge.net/svnroot/pyspec/trunk/pyspec/ccd/files.py) -C/C++ related: gridec (anonymous?? C-code written back in 1997 that uses standard C library) fftw (http://www.fftw.org/) tomoRecon (multi-threaded C++ verion of gridrec. Author: Mark Rivers from APS. http://cars9.uchicago.edu/software/epics/tomoRecon.html) epics (http://www.aps.anl.gov/epics/)

Test characteristics of milk amyloid A ELISA, somatic cell count, and bacteriological culture for detection of intramammary pathogens that cause subclinical mastitis.

PubMed

Jaeger, S; Virchow, F; Torgerson, P R; Bischoff, M; Biner, B; Hartnack, S; Rüegg, S R

2017-09-01

Bovine mastitis is an important disease in the dairy industry, causing economic losses as a result of withheld milk and treatment costs. Several studies have suggested milk amyloid A (MAA) as a promising biomarker in the diagnosis of mastitis. In the absence of a gold standard for diagnosis of subclinical mastitis, we estimated the diagnostic test accuracy of a commercial MAA-ELISA, somatic cell count (SCC), and bacteriological culture using Bayesian latent class modeling. We divided intramammary infections into 2 classes: those caused by major pathogens (e.g., Escherichia coli, Staphylococcus aureus, streptococci, and lacto-/enterococci) and those caused by all pathogens (major pathogens plus Corynebacterium bovis, coagulase-negative staphylococci, Bacillus spp., Streptomyces spp.). We applied the 3 diagnostic tests to all samples. Of 433 composite milk samples included in this study, 275 (63.5%) contained at least 1 colony of any bacterial species; of those, 56 contained major pathogens and 219 contained minor pathogens. The remaining 158 samples (36.5%) were sterile. We determined 2 different thresholds for the MAA-ELISA using Bayesian latent class modeling: 3.9 µg/mL to detect mastitis caused by major pathogens and 1.6 µg/mL to detect mastitis caused by all pathogens. The optimal SCC threshold for identification of subclinical mastitis was 150,000 cells/mL; this threshold led to higher specificity (Sp) than 100,000 cells/mL. Test accuracy for major-pathogen intramammary infections was as follows: SCC, sensitivity (Se) 92.6% and Sp 72.9%; MAA-ELISA, Se 81.4% and Sp 93.4%; bacteriological culture, Se 23.8% and Sp 95.2%. Test accuracy for all-pathogen intramammary infections was as follows: SCC, sensitivity 90.3% and Sp 71.8%; MAA-ELISA, Se 88.0% and Sp 65.2%; bacteriological culture, Se 83.8% and Sp 54.8%. We suggest the use of SCC and MAA-ELISA as a combined screening procedure for situations such as a Staphylococcus aureus control program. With Bayesian latent class analysis, we were able to identify a more differentiated use of the 3 diagnostic tools. The MAA-ELISA is a valuable addition to existing tools for the diagnosis of subclinical mastitis. The Authors. Published by the Federation of Animal Science Societies and Elsevier Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

Biomarkers for bile acid diarrhoea in functional bowel disorder with diarrhoea: a systematic review and meta-analysis.

PubMed

Valentin, Nelson; Camilleri, Michael; Altayar, Osama; Vijayvargiya, Priya; Acosta, Andres; Nelson, Alfred D; Murad, M Hassan

2016-12-01

There is no universally available laboratory test to diagnose bile acid diarrhoea (BAD). To conduct a systematic review and meta-analysis to identify a biomarker for idiopathic BAD in patients with functional bowel disorder (FBD) with diarrhoea. We searched multiple databases through 15 May 2015. Data were only available to estimate the diagnostic yield of each test (the prevalence of a positive test). Estimates were pooled across studies using the random effects model. We included 36 studies, enrolling 5028 patients (24 using 75 selenium homotaurocholic acid test ( 75 SeHCAT) retention of <10%, 6 using fasting serum C4, 3 using fasting serum fibroblast growth factor 19 (FGF19) and 2 based on total faecal bile acid (BA) excretion over 48 h). The diagnostic yields (and 95% CI) of abnormal tests were: 0.308 (0.247 to 0.377) for 75 SeHCAT retention (<10%), 0.171 (0.134 to 0.217) for serum C4, 0.248 (0.147 to 0.385) for serum FGF19 and 0.255 (0.071 to 0.606) for total faecal BA excretion over 48 h. The majority of the analyses were associated with substantial heterogeneity. Performance characteristics relative to a gold standard test could not be estimated. Overall, the test with the highest diagnostic yield conducted in the largest number of studies was 75 SeHCAT retention, which is not widely available in many countries outside Europe and Canada. Using different diagnostic tests, 25% (average) of patients with lower FBD with diarrhoea has evidence of idiopathic BAD. These tests serve to identify idiopathic BAD among patients with FBD with diarrhoea. Further studies are required to appraise the performance characteristics of tests for idiopathic BAD. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Positive Regulation of Staphylococcal Enterotoxin H by Rot (Repressor of Toxin) Protein and Its Importance in Clonal Complex 81 Subtype 1 Lineage-Related Food Poisoning

PubMed Central

Sato'o, Yusuke; Hisatsune, Junzo; Nagasako, Yuria; Ono, Hisaya K.; Omoe, Katsuhiko

2015-01-01

We previously demonstrated the clonal complex 81 (CC81) subtype 1 lineage is the major staphylococcal food poisoning (SFP)-associated lineage in Japan (Y. Sato'o et al., J Clin Microbiol 52:2637–2640, 2014, http://dx.doi.org/10.1128/JCM.00661-14). Strains of this lineage produce staphylococcal enterotoxin H (SEH) in addition to SEA. However, an evaluation of the risk for the recently reported SEH has not been sufficiently conducted. We first searched for staphylococcal enterotoxin (SE) genes and SE proteins in milk samples that caused a large SFP outbreak in Japan. Only SEA and SEH were detected, while there were several SE genes detected in the samples. We next designed an experimental model using a meat product to assess the productivity of SEs and found that only SEA and SEH were detectably produced in situ. Therefore, we investigated the regulation of SEH production using a CC81 subtype 1 isolate. Through mutant analysis of global regulators, we found the repressor of toxin (Rot) functioned oppositely as a stimulator of SEH production. SEA production was not affected by Rot. seh mRNA expression correlated with rot both in media and on the meat product, and the Rot protein was shown to directly bind to the seh promoter. The seh promoter sequence was predicted to form a loop structure and to hide the RNA polymerase binding sequences. We propose Rot binds to the promoter sequence of seh and unfolds the secondary structure that may lead the RNA polymerase to bind the promoter, and then seh mRNA transcription begins. This alternative Rot regulation for SEH may contribute to sufficient toxin production by the CC81 subtype 1 lineage in foods to induce SFP. PMID:26341202

Positive Regulation of Staphylococcal Enterotoxin H by Rot (Repressor of Toxin) Protein and Its Importance in Clonal Complex 81 Subtype 1 Lineage-Related Food Poisoning.

PubMed

Sato'o, Yusuke; Hisatsune, Junzo; Nagasako, Yuria; Ono, Hisaya K; Omoe, Katsuhiko; Sugai, Motoyuki

2015-11-01

We previously demonstrated the clonal complex 81 (CC81) subtype 1 lineage is the major staphylococcal food poisoning (SFP)-associated lineage in Japan (Y. Sato'o et al., J Clin Microbiol 52:2637-2640, 2014, http://dx.doi.org/10.1128/JCM.00661-14). Strains of this lineage produce staphylococcal enterotoxin H (SEH) in addition to SEA. However, an evaluation of the risk for the recently reported SEH has not been sufficiently conducted. We first searched for staphylococcal enterotoxin (SE) genes and SE proteins in milk samples that caused a large SFP outbreak in Japan. Only SEA and SEH were detected, while there were several SE genes detected in the samples. We next designed an experimental model using a meat product to assess the productivity of SEs and found that only SEA and SEH were detectably produced in situ. Therefore, we investigated the regulation of SEH production using a CC81 subtype 1 isolate. Through mutant analysis of global regulators, we found the repressor of toxin (Rot) functioned oppositely as a stimulator of SEH production. SEA production was not affected by Rot. seh mRNA expression correlated with rot both in media and on the meat product, and the Rot protein was shown to directly bind to the seh promoter. The seh promoter sequence was predicted to form a loop structure and to hide the RNA polymerase binding sequences. We propose Rot binds to the promoter sequence of seh and unfolds the secondary structure that may lead the RNA polymerase to bind the promoter, and then seh mRNA transcription begins. This alternative Rot regulation for SEH may contribute to sufficient toxin production by the CC81 subtype 1 lineage in foods to induce SFP. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Cluster-Randomized Trial of Personalized Site Performance Feedback in Get With The Guidelines-Heart Failure.

PubMed

DeVore, Adam D; Cox, Margueritte; Heidenreich, Paul A; Fonarow, Gregg C; Yancy, Clyde W; Eapen, Zubin J; Peterson, Eric D; Hernandez, Adrian F

2015-07-01

There is significant variation in the delivery of evidence-based care for patients with heart failure (HF), but there is limited evidence defining the best methods to improve the quality of care. We performed a cluster-randomized trial of personalized site performance feedback at 147 hospitals participating in the Get With The Guidelines-Heart Failure quality improvement program from October 2009 to March 2011. The intervention provided sites with specific data on their heart failure achievement and quality measures in addition to the usual Get With The Guidelines-Heart Failure tools. The primary outcome for our trial was improvement in site composite quality of care score. Overall, 73 hospitals (n=33 886 patients) received the intervention, whereas 74 hospitals (n=37 943 patients) did not. One year after the intervention, both the intervention and control arms had a similar mean change in percentage points in their composite quality score (absolute change, +0.31 [SE, 1.51] versus +3.18 [SE, 1.68] in control; P=0.21). Similarly, none of the individual achievement measures or quality measures improved more at intervention versus control hospitals. Our site-based intervention, which included personalized site feedback on adherence to quality metrics, was not able to elicit more quality improvement beyond that already associated with participation in the Get With The Guidelines-Heart Failure program. URL: http://www.clinicaltrials.gov. Unique identifier: NCT00979264. © 2015 American Heart Association, Inc.

DNASU plasmid and PSI:Biology-Materials repositories: resources to accelerate biological research

PubMed Central

Seiler, Catherine Y.; Park, Jin G.; Sharma, Amit; Hunter, Preston; Surapaneni, Padmini; Sedillo, Casey; Field, James; Algar, Rhys; Price, Andrea; Steel, Jason; Throop, Andrea; Fiacco, Michael; LaBaer, Joshua

2014-01-01

The mission of the DNASU Plasmid Repository is to accelerate research by providing high-quality, annotated plasmid samples and online plasmid resources to the research community through the curated DNASU database, website and repository (http://dnasu.asu.edu or http://dnasu.org). The collection includes plasmids from grant-funded, high-throughput cloning projects performed in our laboratory, plasmids from external researchers, and large collections from consortia such as the ORFeome Collaboration and the NIGMS-funded Protein Structure Initiative: Biology (PSI:Biology). Through DNASU, researchers can search for and access detailed information about each plasmid such as the full length gene insert sequence, vector information, associated publications, and links to external resources that provide additional protein annotations and experimental protocols. Plasmids can be requested directly through the DNASU website. DNASU and the PSI:Biology-Materials Repositories were previously described in the 2010 NAR Database Issue (Cormier, C.Y., Mohr, S.E., Zuo, D., Hu, Y., Rolfs, A., Kramer, J., Taycher, E., Kelley, F., Fiacco, M., Turnbull, G. et al. (2010) Protein Structure Initiative Material Repository: an open shared public resource of structural genomics plasmids for the biological community. Nucleic Acids Res., 38, D743–D749.). In this update we will describe the plasmid collection and highlight the new features in the website redesign, including new browse/search options, plasmid annotations and a dynamic vector mapping feature that was developed in collaboration with LabGenius. Overall, these plasmid resources continue to enable research with the goal of elucidating the role of proteins in both normal biological processes and disease. PMID:24225319

Ca2+ block and flickering both contribute to the negative slope of the IV curve in BK channels.

PubMed

Schroeder, Indra; Thiel, Gerhard; Hansen, Ulf-Peter

2013-04-01

Single-channel current-voltage (IV) curves of human large-conductance, voltage- and Ca(2+)-activated K(+) (BK) channels are quite linear in 150 mM KCl. In the presence of Ca(2+) and/or Mg(2+), they show a negative slope conductance at high positive potentials. This is generally explained by a Ca(2+)/Mg(2+) block as by Geng et al. (2013. J. Gen. Physiol. http://dx.doi.org/10.1085/jgp.201210955) in this issue. Here, we basically support this finding but add a refinement: the analysis of the open-channel noise by means of β distributions reveals what would be found if measurements were done with an amplifier of sufficient temporal resolution (10 MHz), namely that the block by 2.5 mM Ca(2+) and 2.5 mM Mg(2+) per se would only cause a saturating curve up to +160 mV. Further bending down requires the involvement of a second process related to flickering in the microsecond range. This flickering is hardly affected by the presence or absence of Ca(2+)/Mg(2+). In contrast to the experiments reported here, previous experiments in BK channels (Schroeder and Hansen. 2007. J. Gen. Physiol. http://dx.doi.org/10.1085/jgp.200709802) showed saturating IV curves already in the absence of Ca(2+)/Mg(2+). The reason for this discrepancy could not be identified so far. However, the flickering component was very similar in the old and new experiments, regardless of the occurrence of noncanonical IV curves.

Fast and accurate resonance assignment of small-to-large proteins by combining automated and manual approaches.

PubMed

Niklasson, Markus; Ahlner, Alexandra; Andresen, Cecilia; Marsh, Joseph A; Lundström, Patrik

2015-01-01

The process of resonance assignment is fundamental to most NMR studies of protein structure and dynamics. Unfortunately, the manual assignment of residues is tedious and time-consuming, and can represent a significant bottleneck for further characterization. Furthermore, while automated approaches have been developed, they are often limited in their accuracy, particularly for larger proteins. Here, we address this by introducing the software COMPASS, which, by combining automated resonance assignment with manual intervention, is able to achieve accuracy approaching that from manual assignments at greatly accelerated speeds. Moreover, by including the option to compensate for isotope shift effects in deuterated proteins, COMPASS is far more accurate for larger proteins than existing automated methods. COMPASS is an open-source project licensed under GNU General Public License and is available for download from http://www.liu.se/forskning/foass/tidigare-foass/patrik-lundstrom/software?l=en. Source code and binaries for Linux, Mac OS X and Microsoft Windows are available.

Giving advice on cost effective measures for a cleaner Baltic Sea: a challenge for science.

PubMed

Wulff, F; Bonsdorff, E; Gren, I M; Johansson, S; Stigebrandt, A

2001-08-01

The Baltic Sea is one of the world's seas that is most severely affected by human activities. Although there is an international agreement that nutrient input to the Baltic should be reduced, the measures taken so far have not resulted in major reductions in nutrient inputs nor in environmental improvements. The reasons for this are partly due to lack of knowledge on large-scale relationships and couplings between physics, biogeochemistry and ecological properties. But there is also a lack of overall drainage basin-wide analyses on cost-effective measures. There is a danger in making the wrong decisions, e.g. implement reduction schemes that are at worst ineffective or at best, far from cost effective. Researchers from many disciplines are faced with a common challenge: To develop a decision-support system, which can be used as the scientific base for cost-effective measures for the entire Baltic Sea. Such an effort is now being made within the research program MARE (http://www.mare.su.se).

The ADS All Sky Survey: footprints of astronomy literature, in the sky

NASA Astrophysics Data System (ADS)

Pepe, Alberto; Goodman, A. A.; Muench, A. A.; Seamless Astronomy Group at the CfA

2014-01-01

The ADS All-Sky Survey (ADSASS) aims to transform the NASA Astrophysics Data System (ADS), widely known for its unrivaled value as a literature resource for astronomers, into a data resource. The ADS is not a data repository per se, but it implicitly contains valuable holdings of astronomical data, in the form of images, tables and object references contained within articles. The objective of the ADSASS effort is to extract these data and make them discoverable and available through existing data viewers. In this talk, the ADSASS viewer - http://adsass.org/ - will be presented: a sky heatmap of astronomy articles based on the celestial objects they reference. The ADSASS viewer is as an innovative research and visual search tool for it allows users to explore astronomical literature based on celestial location, rather than keyword string. The ADSASS is a NASA-funded initiative carried out by the Seamless Astronomy Group at the Harvard-Smithsonian Center for Astrophysics.

FTIR spectroscopic study of biofilms formed by the rhizobacterium Azospirillum brasilense Sp245 and its mutant Azospirillum brasilense Sp245.1610

NASA Astrophysics Data System (ADS)

Tugarova, Anna V.; Scheludko, Andrei V.; Dyatlova, Yulia A.; Filip'echeva, Yulia A.; Kamnev, Alexander A.

2017-07-01

Biofilms are spatially and metabolically structured communities of microorganisms, representing a mode of their existence which is ubiquitous in nature, with cells localised within an extracellular biopolymeric matrix, attached to each other, at an interface. For plant-growth-promoting rhizobacteria (PGPR), the formation of biofilms is of special importance due to their primary localisation at the surface of plant root systems. In this work, FTIR spectroscopy was used, for the first time for bacteria of the genus Azospirillum, to comparatively study 6-day-mature biofilms formed on the surface of ZnSe discs by the rhizobacterium Azospirillum brasilense Sp245 and its mutant A. brasilense Sp245.1610. The mutant strain, having an Omegon Km insertion in the gene of lipid metabolism fabG1 on the plasmid AZOBR_p1, as compared to the wild-type strain Sp245 (see http://dx.doi.org/10.1134/S1022795413110112)

Foggy perception slows us down

PubMed Central

Pretto, Paolo; Bresciani, Jean-Pierre; Rainer, Gregor; Bülthoff, Heinrich H

2012-01-01

Visual speed is believed to be underestimated at low contrast, which has been proposed as an explanation of excessive driving speed in fog. Combining psychophysics measurements and driving simulation, we confirm that speed is underestimated when contrast is reduced uniformly for all objects of the visual scene independently of their distance from the viewer. However, we show that when contrast is reduced more for distant objects, as is the case in real fog, visual speed is actually overestimated, prompting drivers to decelerate. Using an artificial anti-fog—that is, fog characterized by better visibility for distant than for close objects, we demonstrate for the first time that perceived speed depends on the spatial distribution of contrast over the visual scene rather than the global level of contrast per se. Our results cast new light on how reduced visibility conditions affect perceived speed, providing important insight into the human visual system. DOI: http://dx.doi.org/10.7554/eLife.00031.001 PMID:23110253

Integrated action of pheromone signals in promoting courtship behavior in male mice

PubMed Central

Haga-Yamanaka, Sachiko; Ma, Limei; He, Jie; Qiu, Qiang; Lavis, Luke D; Looger, Loren L; Yu, C Ron

2014-01-01

The mammalian vomeronasal organ encodes pheromone information about gender, reproductive status, genetic background and individual differences. It remains unknown how pheromone information interacts to trigger innate behaviors. In this study, we identify vomeronasal receptors responsible for detecting female pheromones. A sub-group of V1re clade members recognizes gender-identifying cues in female urine. Multiple members of the V1rj clade are cognate receptors for urinary estrus signals, as well as for sulfated estrogen (SE) compounds. In both cases, the same cue activates multiple homologous receptors, suggesting redundancy in encoding female pheromone cues. Neither gender-specific cues nor SEs alone are sufficient to promote courtship behavior in male mice, whereas robust courtship behavior can be induced when the two cues are applied together. Thus, integrated action of different female cues is required in pheromone-triggered mating behavior. These results suggest a gating mechanism in the vomeronasal circuit in promoting specific innate behavior. DOI: http://dx.doi.org/10.7554/eLife.03025.001 PMID:25073926

EVALLER: a web server for in silico assessment of potential protein allergenicity

PubMed Central

Barrio, Alvaro Martinez; Soeria-Atmadja, Daniel; Nistér, Anders; Gustafsson, Mats G.; Hammerling, Ulf; Bongcam-Rudloff, Erik

2007-01-01

Bioinformatics testing approaches for protein allergenicity, involving amino acid sequence comparisons, have evolved appreciably over the last several years to increased sophistication and performance. EVALLER, the web server presented in this article is based on our recently published ‘Detection based on Filtered Length-adjusted Allergen Peptides’ (DFLAP) algorithm, which affords in silico determination of potential protein allergenicity of high sensitivity and excellent specificity. To strengthen bioinformatics risk assessment in allergology EVALLER provides a comprehensive outline of its judgment on a query protein's potential allergenicity. Each such textual output incorporates a scoring figure, a confidence numeral of the assignment and information on high- or low-scoring matches to identified allergen-related motifs, including their respective location in accordingly derived allergens. The interface, built on a modified Perl Open Source package, enables dynamic and color-coded graphic representation of key parts of the output. Moreover, pertinent details can be examined in great detail through zoomed views. The server can be accessed at http://bioinformatics.bmc.uu.se/evaller.html. PMID:17537818

The SubCons webserver: A user friendly web interface for state-of-the-art subcellular localization prediction.

PubMed

Salvatore, M; Shu, N; Elofsson, A

2018-01-01

SubCons is a recently developed method that predicts the subcellular localization of a protein. It combines predictions from four predictors using a Random Forest classifier. Here, we present the user-friendly web-interface implementation of SubCons. Starting from a protein sequence, the server rapidly predicts the subcellular localizations of an individual protein. In addition, the server accepts the submission of sets of proteins either by uploading the files or programmatically by using command line WSDL API scripts. This makes SubCons ideal for proteome wide analyses allowing the user to scan a whole proteome in few days. From the web page, it is also possible to download precalculated predictions for several eukaryotic organisms. To evaluate the performance of SubCons we present a benchmark of LocTree3 and SubCons using two recent mass-spectrometry based datasets of mouse and drosophila proteins. The server is available at http://subcons.bioinfo.se/. © 2017 The Protein Society.

Fast and Accurate Resonance Assignment of Small-to-Large Proteins by Combining Automated and Manual Approaches

PubMed Central

Niklasson, Markus; Ahlner, Alexandra; Andresen, Cecilia; Marsh, Joseph A.; Lundström, Patrik

2015-01-01

The process of resonance assignment is fundamental to most NMR studies of protein structure and dynamics. Unfortunately, the manual assignment of residues is tedious and time-consuming, and can represent a significant bottleneck for further characterization. Furthermore, while automated approaches have been developed, they are often limited in their accuracy, particularly for larger proteins. Here, we address this by introducing the software COMPASS, which, by combining automated resonance assignment with manual intervention, is able to achieve accuracy approaching that from manual assignments at greatly accelerated speeds. Moreover, by including the option to compensate for isotope shift effects in deuterated proteins, COMPASS is far more accurate for larger proteins than existing automated methods. COMPASS is an open-source project licensed under GNU General Public License and is available for download from http://www.liu.se/forskning/foass/tidigare-foass/patrik-lundstrom/software?l=en. Source code and binaries for Linux, Mac OS X and Microsoft Windows are available. PMID:25569628

Efficacy and safety of left atrial appendage closure versus medical treatment in atrial fibrillation: a network meta-analysis from randomised trials.

PubMed

Sahay, Shweta; Nombela-Franco, Luis; Rodes-Cabau, Josep; Jimenez-Quevedo, Pilar; Salinas, Pablo; Biagioni, Corina; Nuñez-Gil, Ivan; Gonzalo, Nieves; de Agustín, Jose Alberto; Del Trigo, Maria; Perez de Isla, Leopoldo; Fernández-Ortiz, Antonio; Escaned, Javier; Macaya, Carlos

2017-01-15

The effectiveness of vitamin K antagonist (VKA) versus placebo and antiplatelet therapy (APT) is well established for stroke prevention in atrial fibrillation (AF). Non-vitamin K antagonist oral anticoagulants (NOAC) are mostly superior to VKA in stroke and intracranial bleeding prevention. Recent randomised controlled trials (RCTs) suggested the non-inferiority of percutaneous left atrial appendage closure (LAAC) versus VKA. However, comparisons between LAAC versus placebo, APT or NOAC are lacking. The purpose of this network meta-analysis was to assess the efficacy and safety of LAAC compared with other strategies for stroke prevention in patients with AF. We pooled together all RCTs comparing warfarin with placebo, APT or NOAC in patients with AF using meta-analysis guidelines. Two major trials of LAAC were also included and a network meta-analysis was performed to compare the impact of LAAC on mortality, stroke/systemic embolism (SE) and major bleeding in relation to medical treatment. The network meta-analysis included 19 RCTs with a total of 87 831 patients with AF receiving anticoagulants, APT, placebo or LAAC. Indirect comparison with network meta-analysis using warfarin as the common comparator revealed efficacy benefit favouring LAAC as compared with placebo (mortality: HR 0.38, 95% CI 0.22 to 0.67, p<0.001; stroke/SE: HR 0.24, 95% CI 0.11 to 0.52, p<0.001) and APT (mortality: HR 0.58, 95% CI 0.37 to 0.91, p=0.0018; stroke/SE: HR 0.44, 95% CI 0.23 to 0.86, p=0.017) and similar to NOAC (mortality: HR 0.76, 95% CI 0.50 to 1.16, p=0.211; stroke/SE: HR 1.01, 95% CI 0.53 to 1.92, p=0.969). LAAC showed comparable rates of major bleeding when compared with placebo (HR 2.33, 95% CI 0.67 to 8.09, p=0.183), APT (HR 0.75, 95% CI 0.30 to 1.88, p=0.542) and NOAC (HR 0.80, 95% CI 0.33 to 1.94, p=0.615). The findings of this meta-analysis suggest that LAAC is superior to placebo and APT, and comparable to NOAC for preventing mortality and stroke or SE, with similar bleeding risk in patients with non-valvular AF. However, these results should be interpreted with caution and more studies are needed to further substantiate this advantage, in view of the wide CIs with some variables in the current meta-analysis. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

43 CFR Appendix B to Part 2 - Internet Addresses

Code of Federal Regulations, 2010 CFR

2010-10-01

... Page: http://www.doi.gov 2. DOI FOIA Home Page: http://www.doi.gov/foia/ 3. DOI Reference Guide for Obtaining Information: http://www.doi.gov/foia/foitabl.htm 4. List of DOI Public Affairs Offices: http://www.doi.gov/foia/list.html 5. DOI FOIA Contacts: http://www.doi.gov/foia/contacts.html 6. DOI FOIA...

43 CFR Appendix B to Part 2 - Internet Addresses

Code of Federal Regulations, 2012 CFR

2012-10-01

... Page: http://www.doi.gov 2. DOI FOIA Home Page: http://www.doi.gov/foia/ 3. DOI Reference Guide for Obtaining Information: http://www.doi.gov/foia/foitabl.htm 4. List of DOI Public Affairs Offices: http://www.doi.gov/foia/list.html 5. DOI FOIA Contacts: http://www.doi.gov/foia/contacts.html 6. DOI FOIA...

News from Online: Industrial Chemicals and Polymers

NASA Astrophysics Data System (ADS)

Sweeney Judd, Carolyn

1999-02-01

Paper or plastic? I am asked this question every time I go grocery shopping. Asked another way, the question is, "Which polymer do you want?" To learn about polymers, go shopping at a great site from the University of Southern Mississippi, The Macrogalleria, a cyberwonderland of polymer fun at http://www.psrc.usm.edu/macrog/index.html . Plan to spend some time here. Bring along Chime and Shockwave plug-ins or download them from The Macrogalleria. The Macrogalleria shopping mall is divided into five levels. On the first level, Polymers are Everywhere at http:/ /www.psrc.usm.edu/macrog/floor1.html, you can visit stores selling sporting goods, food, and clothing. Learn about natural polymers in shoes and in French fries at http://www.psrc.usm.edu/macrog/natupoly.html . Find out about nylon in toothbrushes at http://www.psrc.usm.edu/macrog/nylon.html and about carbon fibers in tennis racquets at http://www.psrc.usm.edu/macrog /carfib.html-great graphics and even better chemistry. Skip up to level three for How They Work at http:/ /www.psrc.usm.edu/macrog/floor3.html. Take a look at the history of rubber on The Cross-linking Page at http:/ /www.psrc.usm.edu/macrog/xlink.html. Move on to level four for Makin' Polymers at http://www.psrc.usm.edu/macrog /floor4.html. Let's go right to the Ziegler-Natta Vinyl Polymerization at http://www.psrc.usm.edu/macrog/ziegler.html . Don't miss the humor in the initial explanation of the process. This page is excellent-with graphics, reactions, and a movie of a polymerization ( http://www.psrc.usm.edu/macrog/movies/zns.html ). This movie is worth seeing several times. Next take a look at another catalyst metallocene at http:/ /www.psrc.usm.edu/macrog/mcene.html. Explanations, graphics, and mechanisms help make this site worth visiting and great for teaching. Several people contributed to The Macrogalleria, with major contributions from Mark Michalovic of the University of Southern Mississippi. Grants were from POLYED, a joint committee of the American Chemical Society Divisions of Polymer Chemistry and Polymeric Materials: Science and Engineering and General Electric Corporation. The POLYED site, http:/ /chemdept.uwsp.edu/polyed/index.htm, is hosted by the University of Wisconsin at Stevens Point. This National Center for Polymer Education is another good place to go for information. More education is available at the Ziegler Research Group Home Page at http://www.chem.ucalgary.ca/groups/ziegler/index.html . Go to Metallocene as Olefin Polymerization Catalysis: An Introduction ( http://www.chem.ucalgary.ca/groups/ziegler/met_intro.html ) for historical accounts of metallocene and Ziegler-Natta catalysts. Movies are available here too. This Canadian site is well-documented and educational. Back at the University of Wisconsin-Madison, The Why Files site at http://whyfiles.news.wisc.edu helps bring important chemical and technology news to the public. Go to the archived files of October 1997 ( http://whyfiles.news.wisc.edu/shorties/catalyst.html ) to find information about the importance of low-temperature metallocene catalysts. The Why Files received funding from the National Science Foundation. Go here for science information in an easy-to-read format. One of the driving forces toward better catalysis is the attempt to reach 100% product, combining efficiency with lowered pollution. Companies can look to the Environmental Protection Agency for information: Environsense at http://es.epa.gov/ is pledged to offer "Common Sense Solutions to Environmental Problems". So where can we get these polymers? The American Chemical Society can help. Go to Chemcylopedia at http://pubs.acs.org/chemcy99/ for great information. Both purchasers and users of chemicals can benefit from this site. Searches can be made on the chemical or on the supplier. Information provided includes CAS Registry Numbers and special shipping requirements as well as potential applications. Do you remember that we started with paper? Let's end with information about making paper. Go to http://www.sci.fi /~saarives/pulpmfl.htm for Ahlstrom Machinery's Typical Offerings for Chemical Pulp Mills. Now this is a chemically rich plant that is worth the trip. Carolyn Sweeney Judd teaches at Houston Community College System, 1300 Holman, Houston, TX 77004; phone: 713/718-6315; email: cjudd@tenet.edu. World Wide Web Addresses The Macrogalleria http://www.psrc.usm.edu/macrog/index.html Polymers Are Everywhere http://www.psrc.usm.edu/macrog/floor1.html Natural Polymers http://www.psrc.usm.edu/macrog/natupoly.html Nylon http://www.psrc.usm.edu/macrog/nylon.html Carbon Fibers http://www.psrc.usm.edu/macrog/carfib.html How They Work http://www.psrc.usm.edu/macrog/floor3.html The Cross-linking Page http://www.psrc.usm.edu/macrog/xlink.html Makin' Polymers http://www.psrc.usm.edu/macrog/floor4.html Ziegler-Natta Vinyl Polymerization http://www.psrc.usm.edu/macrog/ziegler.html Syndiotactic Ziegler-Natta Polymerization (movie, Shockwave plug-in required for viewing) at http://www.psrc.usm.edu/macrog/movies/zns.html Metallocene Catalysis Polymerization http://www.psrc.usm.edu/macrog/mcene.html POLYED Welcome Page http://chemdept.uwsp.edu/polyed/index.htm Ziegler Research Group Home Page http://www.chem.ucalgary.ca/groups/ziegler/index.html Metallocene as Olefin Polymerization Catalysis: An Introduction at http://www.chem.ucalgary.ca/groups/ziegler/met_intro.html The Why Files http://whyfiles.news.wisc.edu Low-Temperature Metallocene Catalysts http://whyfiles.news.wisc.edu/shorties/catalyst.html Environsense http://es.epa.gov/ Chemcylopedia 99 http://pubs.acs.org/chemcy99/ Ahlstrom Machinery's Typical Offerings for Chemical Pulp Mills at http://www.sci.fi/~saarives/pulpmfl.htm access date for all sites: December 1998

An outflow in the Seyfert ESO 362-G18 revealed by Gemini-GMOS/IFU observations

NASA Astrophysics Data System (ADS)

Humire, Pedro K.; Nagar, Neil M.; Finlez, Carolina; Firpo, Verónica; Slater, Roy; Lena, Davide; Soto-Pinto, Pamela; Muñoz-Vergara, Dania; Riffel, Rogemar A.; Schmitt, Henrique R.; Kraemer, Steven B.; Schnorr-Müller, Allan; Fischer, Travis C.; Robinson, Andrew; Storchi-Bergmann, Thaisa; Crenshaw, Mike; Elvis, Martin S.

2018-06-01

We present two-dimensional stellar and gaseous kinematics of the inner 0.7 × 1.2 kpc2 of the Seyfert 1.5 galaxy ESO 362-G18, derived from optical (4092-7338 Å) spectra obtained with the GMOS integral field spectrograph on the Gemini South telescope at a spatial resolution of ≈170 pc and spectral resolution of 36 km s-1. ESO 362-G18 is a strongly perturbed galaxy of morphological type Sa or S0/a, with a minor merger approaching along the NE direction. Previous studies have shown that the [O III] emission shows a fan-shaped extension of ≈10'' to the SE. We detect the [O III] doublet, [N II] and Hα emission lines throughout our field of view. The stellar kinematics is dominated by circular motions in the galaxy plane, with a kinematic position angle of ≈137° and is centred approximately on the continuum peak. The gas kinematics is also dominated by rotation, with kinematic position angles ranging from 122° to 139°, projected velocity amplitudes of the order of 100 km s-1, and a mean velocity dispersion of 100 km s-1. A double-Gaussian fit to the [O III]λ5007 and Hα lines, which have the highest signal to noise ratios of the emission lines, reveal two kinematic components: (1) a component at lower radial velocities which we interpret as gas rotating in the galactic disk; and (2) a component with line of sight velocities 100-250 km s-1 higher than the systemic velocity, interpreted as originating in the outflowing gas within the AGN ionization cone. We estimate a mass outflow rate of 7.4 × 10-2 M⊙ yr-1 in the SE ionization cone (this rate doubles if we assume a biconical configuration), and a mass accretion rate on the supermassive black hole (SMBH) of 2.2 × 10-2 M⊙ yr-1. The total ionized gas mass within 84 pc of the nucleus is 3.3 × 105 M⊙; infall velocities of 34 km s-1 in this gas would be required to feed both the outflow and SMBH accretion. The reduced datacube (FITS file) is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/614/A94

THERMINATOR: THERMal heavy-IoN generATOR

NASA Astrophysics Data System (ADS)

Kisiel, Adam; Tałuć, Tomasz; Broniowski, Wojciech; Florkowski, Wojciech

2006-04-01

THERMINATOR is a Monte Carlo event generator designed for studying of particle production in relativistic heavy-ion collisions performed at such experimental facilities as the SPS, RHIC, or LHC. The program implements thermal models of particle production with single freeze-out. It performs the following tasks: (1) generation of stable particles and unstable resonances at the chosen freeze-out hypersurface with the local phase-space density of particles given by the statistical distribution factors, (2) subsequent space-time evolution and decays of hadronic resonances in cascades, (3) calculation of the transverse-momentum spectra and numerous other observables related to the space-time evolution. The geometry of the freeze-out hypersurface and the collective velocity of expansion may be chosen from two successful models, the Cracow single-freeze-out model and the Blast-Wave model. All particles from the Particle Data Tables are used. The code is written in the object-oriented c++ language and complies to the standards of the ROOT environment. Program summaryProgram title:THERMINATOR Catalogue identifier:ADXL_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADXL_v1_0 Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland RAM required to execute with typical data:50 Mbytes Number of processors used:1 Computer(s) for which the program has been designed: PC, Pentium III, IV, or Athlon, 512 MB RAM not hardware dependent (any computer with the c++ compiler and the ROOT environment [R. Brun, F. Rademakers, Nucl. Instrum. Methods A 389 (1997) 81, http://root.cern.ch] Operating system(s) for which the program has been designed:Linux: Mandrake 9.0, Debian 3.0, SuSE 9.0, Red Hat FEDORA 3, etc., Windows XP with Cygwin ver. 1.5.13-1 and gcc ver. 3.3.3 (cygwin special)—not system dependent External routines/libraries used: ROOT ver. 4.02.00 Programming language:c++ Size of the package: (324 KB directory 40 KB compressed distribution archive), without the ROOT libraries (see http://root.cern.ch for details on the ROOT [R. Brun, F. Rademakers, Nucl. Instrum. Methods A 389 (1997) 81, http://root.cern.ch] requirements). The output files created by the code need 1.1 GB for each 500 events. Distribution format: tar gzip file Number of lines in distributed program, including test data, etc.: 6534 Number of bytes in ditribution program, including test data, etc.:41 828 Nature of the physical problem: Statistical models have proved to be very useful in the description of soft physics in relativistic heavy-ion collisions [P. Braun-Munzinger, K. Redlich, J. Stachel, 2003, nucl-th/0304013. [2

Cementless Oxford medial unicompartimental knee replacement: an independent series with a 5-year-follow-up.

PubMed

Panzram, Benjamin; Bertlich, Ines; Reiner, Tobias; Walker, Tilman; Hagmann, Sébastien; Gotterbarm, Tobias

2017-07-01

Cemented unicompartmental knee replacement (UKR) has proven excellent long-term survival rates and functional scores in Price et al. (Clin Orthop Relat Res 435:171-180, 2005), Price and Svard (Clin Orthop Relat Res 469(1):174-179, 2011) and Murray et al. (Bone Joint Surg Br 80(6):983-989, 1998). The main causes for revision, aseptic loosening and pain of unknown origin might be addressed by cementless UKR in Liddle et al. (Bone Joint J 95-B(2):181-187, 2013), Pandit et al. (J Bone Joint Surg Am 95(15):1365-1372, 2013), National Joint Registry for England, Wales and Northern Ireland: 10th Annual Report 2013 ( http://www.njrcentre.org.uk/njrcentre/Portals/0/Documents/England/Reports/10th_annual_report/NJR%2010th%20Annual%20Report%202013%20B.pdf , 2013), Swedish Knee Arthroplasty Register: Annual Report 2013 ( http://www.myknee.se/pdf/SKAR2013_Eng.pdf , 2013). This single-centre retrospective cohort study reports the 5-year follow-up results of our first 30 consecutively implanted cementless Oxford UKR (OUKR). Clinical outcome was measured using the OKS, AKSS, range of movement and level of pain (visual analogue scale). The results were compared to cemented OUKR in a matched-pair analysis. Implant survival was 89.7%. One revision each was performed due to tibial fracture, progression of osteoarthritis (OA) and inlay dislocation. The 5-year survival rate of the cementless group was 89.7% and of the cemented group 94.1%. Both groups showed excellent postoperative clinical scores. Cementless fixation shows good survival rates and clinical outcome compared to cemented fixation.

News from Online: A Spectrum of Color

NASA Astrophysics Data System (ADS)

Sweeney Judd, Carolyn

1999-06-01

Thomas Chasteen's site ( http://www.shsu.edu/~chm_tgc/sounds/sound.html) shows how to separate colors using a tuneable monochromator. This graphic comes from his monochromator animation ( http://www.shsu.edu/~chemistry/monochromator/mono.gif). Science Media's site ( http://www.scimedia.com/index.html#scimedia) includes spectroscopy tutorials by Brian Tissue. This graphic can be found at http://www.scimedia.com/chem-ed/light/graphics/em-rad.gif (©1998 B. M. Tissue, www.scimedia.com). All the colors in the rainbow! Now that is a good place to start. Go to About Rainbows ( http://www.unidata.ucar.edu/staff/blynds/rnbw.html), a tutorial from astronomer Beverly Lynds, working with the University Corporation for Atmospheric Research. The tutorial begins with a historical perspective, complete with a sketch by René Descartes in 1637. The bibliography makes this tutorial a good starting point for color exploration. About Rainbows brings you questions to explorefor example, "What happens when you look at a rainbow through dark glasses?" Try the links to these other sites. Project SkyMath: Making Mathematical Connections ( http://www.unidata.ucar.edu/staff/blynds/Skymath.html) is especially for the middle school student. Reproducible masters of these teaching modules can be printed in English and Spanish. From Project SkyMath, you can go to Blue-Skies, a user-friendly graphical interface from The Weather Underground at the University of Michigan ( http://groundhog.sprl.umich.edu/BS.html). And speaking of blue skies, look at a great site, Why is the Sky Blue at http://acept.la.asu.edu/PiN/act/sky/sky.shtml. This is a super site from the Arizona Collaborative for Excellence in the Preparation of Teachers, by the Department of Physics and Astronomy at Arizona State University. If you go to Patterns in Nature: Light and Optics at http://acept.la.asu.edu/PiN/act/activities.shtml, plan to spend some time, for it is wonderful. Another link from the About Rainbows tutorial goes to an experiment that is suitable for older students, Circles of Light--The Mathematics of Rainbows at http://www.geom.umn.edu/education/calc-init/rainbow/. Frederick J. Wicklin and Paul Edelman of the University of Minnesota note that this comprehensive lab is based on a module developed by Steven Janke. Go back to About Rainbows to link to a Java applet, allowing you to change the incident angle and color of light striking a water droplet. This great teaching device is from Fu-Kwun Hwang of the National Taiwan Normal University at http://science.kongju.ac.kr/phys/shin/experiment/ntnujava /Rainbow/rainbow.html. And while you are here in this site (choose English or Chinese), look at the more than 30 Java applets created by F.-K. Hwang at http://science.kongju.ac.kr/phys/shin/experiment/ntnujava/index.html. The interactive applet on Shadow/Image and Color is great fun, (http://science.kongju.ac.kr/phys/shin/experiment/ntnujava/shadow /shadow.html). From mixing colors, we can go to Thomas Chasteen's fine work at http://www.shsu.edu/~chm_tgc/sounds/sound.html for an animation (and movie also) of how to separate colors using a tuneable monochromator ( http://www.shsu.edu/~chemistry/monochromator/mono.gif). This colorful graphic, showing incoming parallel white light, is clipped from that monochromator animation. While you are here at this site at Sam Houston State University, look at the other great animations and movies, including a movie showing solution-phase chemiluminescence at http://www.shsu.edu/~chm_tgc/chemilumdir/movie.html. So now that we have explored the breaking down of light into its component colors, we need to also look at another process--polarizing light. Let's go to Science Media's comprehensive site ( http://www.scimedia.com/index.html#scimedia) to examine polarized light ( http://www.scimedia.com/chem-ed/spec/molec/polarim.htm). Of course, most sunglasses polarize light--bringing us back to the question of the rainbow again. Explore here for a while--appreciate the beautiful visible electromagnetic spectrum at http://www.scimedia.com/chem-ed/light/graphics/em-visib.jpg. Great spectroscopy tutorials from Brian Tissue of the Virginia Polytechnic Institute and State University are found at Science Media's site. One of my favorite graphics ( http://www.scimedia.com/chem-ed/light/graphics/em-rad.gif) reminds us of why light is electromagnetic radiation. But how to we actually see color? Go to the Access Excellence Classic Collection sponsored by Genentech, Inc. (http://www.gene.com/ae/AE/AEC/CC/). From here, go to How We See: The First Steps of Human Vision at http://www.gene.com/ae/AE/AEC/CC/vision_background.html. Here are good graphics and explanations of the roles of rod and cone cells, and lots more! And marvel a little the next time you see a rainbow. World Wide Web Addresses About Rainbows http://www.unidata.ucar.edu/staff/blynds/rnbw.html Project SkyMath: Making Mathematical Connections http://www.unidata.ucar.edu/staff/blynds/Skymath.html The Weather Underground at the University of Michigan--Blue- Skies http://groundhog.sprl.umich.edu/BS.html Why is the Sky Blue http://acept.la.asu.edu/PiN/act/sky/sky.shtml Patterns in NatureLight and Optics Activities http://acept.la.asu.edu/PiN/act/activities.shtml Circles of Lightthe Mathematics of Rainbows http://www.geom.umn.edu/education/calc-init/rainbow/ The Physics of a Rainbow http://science.kongju.ac.kr/phys/shin/experiment/ntnujava /Rainbow/rainbow.html The NTNU Virtual Physics Laboratory http://science.kongju.ac.kr/phys/shin/experiment/ntnujava /index.html Shadow/Image and Color http://science.kongju.ac.kr/phys/shin/experiment/ntnujava/shadow/shadow.html Thomas Chasteen's Chemistry-Based QuickTime Movies, Animations, and Streaming Audio http://www.shsu.edu/~chm_tgc/sounds/sound.html Tuneable Monochromator http://www.shsu.edu/~chemistry/monochromator/mono.gif The Chemiluminescence Home Page http://www.shsu.edu/~chm_tgc/chemilumdir/movie.html Science Hypermedia Home Page http://www.scimedia.com/index.html#scimedia Polarimetry http://www.scimedia.com/chem-ed/spec/molec/polarim.htm The Visible Spectrum http://www.scimedia.com/chem-ed/light/graphics/em-visib.jpg Propagation Direction of Electromagnetic Radiation http://www.scimedia.com/chem-ed/light/graphics/em-rad.gif Access Excellence Classic Collection http://www.gene.com/ae/AE/AEC/CC/ How We SeeThe First Steps of Human Vision http://www.gene.com/ae/AE/AEC/CC/vision_background.html access date for all sites: April 1999

10 CFR 431.75 - Materials incorporated by reference.

Code of Federal Regulations, 2010 CFR

2010-01-01

...-Conditioning Engineers, Inc., 1971 Tullie Circle, NE., Atlanta, GA 30329, or http://www.ashrae.org/book..., CO 80112, or http://global.ihs.com/, or http://webstore.ansi.org/ansidocstore/. (iii) The UL Standard... 07922, or http://www.gamanet.org/publist/hydroordr.htm. ...

Books and Other Resources for Education about the August 21, 2017, Solar Eclipse

NASA Astrophysics Data System (ADS)

Pasachoff, Jay M.; Fraknoi, Andrew; Kentrianakis, Michael

2017-06-01

As part of our work to reach and educate the 300+ million Americans of all ages about observing the August 21 solar eclipse, especially by being outdoors in the path of totality but also for those who will see only partial phases, we have compiled annotated lists of books, pamphlets, travel guides, websites, and other information useful for teachers, students, and the general public and made them available on the web, at conferences, and through webinars. Our list includes new eclipse books by David Barron, Anthony Aveni, Frank Close, Tyler Nordgren, John Dvorak, Michael Bakich, and others. We list websites accessible to the general public including those of the International Astronomical Union Working Group on Eclipses (http://eclipses.info, which has links to all the sites listed below); the AAS Eclipse 2017 Task Force (http://eclipse2017.aas.org); NASA Heliophysics (http://eclipse.nasa.gov); Fred Espenak (the updated successor to his authoritative "NASA website": http://EclipseWise.com); Michael Zeiler (http://GreatAmericanEclipse.com); Xavier Jubier (http://xjubier.free.fr/en/site_pages/solar_eclipses/); Jay Anderson (meteorology: http://eclipsophile.com); NASA's Eyes (http://eyes.nasa.gov/eyes-on-eclipse.html and its related app); the Astronomical Society of the Pacific (http://www.astrosociety.org/eclipse); Dan McGlaun (http://eclipse2017.org/); Bill Kramer (http://eclipse-chasers.com). Specialized guides include Dennis Schatz and Andrew Fraknoi's Solar Science for teachers (from the National Science Teachers Association:http://www.nsta.org/publications/press/extras/files/solarscience/SolarScienceInsert.pdf), and a printing with expanded eclipse coverage of Jay Pasachoff's, Peterson Field Guide to the Stars and Planets (14th printing of the fourth edition, 2016: http://solarcorona.com).A version of our joint list is to be published in the July issue of the American Journal of Physics as a Resource Letter on Eclipses, adding to JMP's 2010, "Resource Letter SP-1 on Solar Physics," AJP, 78, September, 890-901.

Structural Fingerprinting of Nanocrystals in the Transmission Electron Microscope

NASA Astrophysics Data System (ADS)

Rouvimov, Sergei; Plachinda, Pavel; Moeck, Peter

2010-03-01

Three novel strategies for the structurally identification of nanocrystals in a transmission electron microscope are presented. Either a single high-resolution transmission electron microscopy image [1] or a single precession electron diffractogram (PED) [2] may be employed. PEDs from fine-grained crystal powders may also be utilized. Automation of the former two strategies is in progress and shall lead to statistically significant results on ensembles of nanocrystals. Open-access databases such as the Crystallography Open Database which provides more than 81,500 crystal structure data sets [3] or its mainly inorganic and educational subsets [4] may be utilized. [1] http://www.scientificjournals.org/journals 2007/j/of/dissertation.htm [2] P. Moeck and S. Rouvimov, in: {Drugs and the Pharmaceutical Sciences}, Vol. 191, 2009, 270-313 [3] http://cod.ibt.lt, http://www.crystallography.net, http://cod.ensicaen.fr, http://nanocrystallography.org, http://nanocrystallography.net, http://journals.iucr.org/j/issues/2009/04/00/kk5039/kk5039.pdf [4] http://nanocrystallography.research.pdx.edu/CIF-searchable

SeReNA Project: studying aerosol interactions with cloud microphysics in the Amazon Basin

NASA Astrophysics Data System (ADS)

Correia, A. L.; Catandi, P. B.; Frigeri, F. F.; Ferreira, W. C.; Martins, J.; Artaxo, P.

2012-12-01

Cloud microphysics and its interaction with aerosols is a key atmospheric process for weather and climate. Interactions between clouds and aerosols can impact Earth's radiative balance, its hydrological and energetic cycles, and are responsible for a large fraction of the uncertainty in climatic models. On a planetary scale, the Amazon Basin is one of the most significant land sources of moisture and latent heat energy. Moreover, every year this region undergoes mearked seasonal shifts in its atmospheric state, transitioning from clean to heavily polluted conditions due to the occurrence of seasonal biomass burning fires, that emit large amounts of smoke to the atmosphere. These conditions make the Amazon Basin a special place to study aerosol-cloud interactions. The SeReNA Project ("Remote sensing of clouds and their interaction with aerosols", from the acronym in Portuguese, @SerenaProject on Twitter) is an ongoing effort to experimentally investigate the impact of aerosols upon cloud microphysics in Amazonia. Vertical profiles of droplet effective radius of water and ice particles, in single convective clouds, can be derived from measurements of the emerging radiation on cloud sides. Aerosol optical depth, cloud top properties, and meteorological parameters retrieved from satellites will be correlated with microphysical properties derived for single clouds. Maps of cloud brightness temperature will allow building temperature vs. effective radius profiles for hydrometeors in single clouds. Figure 1 shows an example extracted from Martins et al. (2011), illustrating a proof-of-concept for the kind of result expected within the framework for the SeReNA Project. The results to be obtained will help foster the quantitative knowledge about interactions between aerosols and clouds in a microphysical level. These interactions are a fundamental process in the context of global climatic changes, they are key to understanding basic processes within clouds and how aerosols can influence them. Reference: Martins et al. (2011) ACP, v.11, p.9485-9501. Available at: http://bit.ly/martinspaper Figure 1. Brightness temperature (left panel) and thermodynamic phase (right) of hydrometeors in the convective cloud shown in the middle panel. Extracted from Martins et al. (2011).

The optical properties of galaxies in the Ophiuchus cluster

NASA Astrophysics Data System (ADS)

Durret, F.; Wakamatsu, K.; Adami, C.; Nagayama, T.; Omega Muleka Mwewa Mwaba, J. M.

2018-05-01

Context. Ophiuchus is one of the most massive clusters known, but due to its low Galactic latitude its optical properties remain poorly known. Aims: We investigate the optical properties of Ophiuchus to obtain clues on the formation epoch of this cluster, and compare them to those of the Coma cluster, which is comparable in mass to Ophiuchus but much more dynamically disturbed. Methods: Based on a deep image of the Ophiuchus cluster in the r' band obtained at the Canada France Hawaii Telescope with the MegaCam camera, we have applied an iterative process to subtract the contribution of the numerous stars that, due to the low Galactic latitude of the cluster, pollute the image, and have obtained a photometric catalogue of 2818 galaxies fully complete at r' = 20.5 mag and still 91% complete at r' = 21.5 mag. We use this catalogue to derive the cluster Galaxy Luminosity Function (GLF) for the overall image and for a region (hereafter the "rectangle" region) covering exactly the same physical size as the region in which the GLF of the Coma cluster was previously studied. We then compute density maps based on an adaptive kernel technique, for different magnitude limits, and define three circular regions covering 0.08, 0.08, and 0.06 deg2, respectively, centred on the cluster (C), on northwest (NW) of the cluster, and southeast (SE) of the cluster, in which we compute the GLFs. Results: The GLF fits are much better when a Gaussian is added to the usual Schechter function, to account for the excess of very bright galaxies. Compared to Coma, Ophiuchus shows a strong excess of bright galaxies. Conclusions: The properties of the two nearby very massive clusters Ophiuchus and Coma are quite comparable, though they seem embedded in different large-scale environments. Our interpretation is that Ophiuchus was built up long ago, as confirmed by its relaxed state (see paper I) while Coma is still in the process of forming. The photometric catalogue of Ophiuchus (full Table B.1) is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/613/A20

NWS Marine Links

Science.gov Websites

mariner. The U.S. Coast Guard Maritime Telecommunications webpage contains an excellent description of /owlie/publication_brochures NOAA Data Buoy Center http://www.ndbc.noaa.gov/ NOAA Weather Radio http /ncdc.html NOAA's National Oceanographic Data Center (NODC) http://www.nodc.noaa.gov NOAA Coastwatch http

RISK ASSESSMENT OF FOOD ALLERGENICITY BY A DATA BASE APPROACH

EPA Science Inventory

The overall goal of the proposal is the further development of our Structural Database of Allergenic Proteins (SDAP) (http://fermi.utmb.edu/SDAP/ Performance Analysis of the HTTP Protocol on Geostationary Satellite Links

NASA Technical Reports Server (NTRS)

Krus, Hans; Allman, Mark; Griner, Jim; Tran, Diepchi

1998-01-01

Various issues associated with HTTP protocol on geostationary satellite links are presented in viewgraph form. Specific topics include: 1) Network reference points; 2) The HTTP 1.0 and 1.1 mechanisms; 3) Experimental setup; 4) TCP and HTTP configuration; 5) Modelling slow start and 6) Results and future work.

Coalition Network Defence Common Operational Picture

DTIC Science & Technology

2010-11-01

27000 .org/ iso -27005.htm [26] ISO 8601:2004, Data elements and interchange formats - Information interchange - Representation of dates and times, http://ww.iso.org, http://en.wikipedia.org/wiki/ISO_8601 ...Regular_expression [25] ISO /IEC 27005:2008, Information technology -- Security techniques -- Information security risk management, http://ww.iso.org,; http://www

78 FR 18233 - Medical Devices; Technical Amendment

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-26

... the right column: Section Remove Add 814.20 http://www.fda.gov/ http://www.fda.gov/ cdrh/devadvice.../ PremarketApproval PMA/default.htm. 822.7 http://www.fda.gov/ http://www.fda.gov/ cdrh/ombudsman/ AboutFDA/ dispute.html. CentersOffices/ OfficeofMedicalPr oductsandTobacco/ CDRH/ CDRHOmbudsman/ default.htm. 822.15...

Some Facts About Asbestos

USGS Publications Warehouse

Virta, R.L.

2001-01-01

For information on historic asbestos mines, historic prospects and natural asbestos occurrences in the U.S., see: Eastern U.S. ---> Open-File Report 2005-1189 (http://pubs.usgs.gov/of/2005/1189/); Central U.S. ---> Open-File Report 2006-1211 (http://pubs.usgs.gov/of/2006/1211/); Rocky Mountain States ---> Open-File Report 2007-1182 (http://pubs.usgs.gov/of/2007/1182/); Southwest U.S. ---> Open-File Report 2008-1095 (http://pubs.usgs.gov/of/2008/1095/). For commodity statistics and information see: http://minerals.usgs.gov/minerals/pubs/commodity/asbestos/

47 CFR 73.3617 - Information available on the Internet.

Code of Federal Regulations, 2010 CFR

2010-10-01

... include copies of public notices and texts of recent decisions. The Media Bureau's address is http://www.fcc.gov/mb/; the Audio Division's address is http://www.fcc.gov/mmb/audio; the Video Division's address is http://www.fcc.gov/mb/video; the Policy Division's address is http://www.fcc.gov/mb/policy; the...

47 CFR 73.3617 - Information available on the Internet.

Code of Federal Regulations, 2013 CFR

2013-10-01

....fcc.gov/mb/; the Audio Division's address is http://www.fcc.gov/mmb/audio; the Video Division's address is http://www.fcc.gov/mb/video; the Policy Division's address is http://www.fcc.gov/mb/policy; the Engineering Division's address is http://www.fcc.gov/mb/engineering; and the Industry Analysis Division's...

47 CFR 73.3617 - Information available on the Internet.

Code of Federal Regulations, 2012 CFR

2012-10-01

....fcc.gov/mb/; the Audio Division's address is http://www.fcc.gov/mmb/audio; the Video Division's address is http://www.fcc.gov/mb/video; the Policy Division's address is http://www.fcc.gov/mb/policy; the Engineering Division's address is http://www.fcc.gov/mb/engineering; and the Industry Analysis Division's...

47 CFR 73.3617 - Information available on the Internet.

Code of Federal Regulations, 2014 CFR

2014-10-01

....fcc.gov/mb/; the Audio Division's address is http://www.fcc.gov/mmb/audio; the Video Division's address is http://www.fcc.gov/mb/video; the Policy Division's address is http://www.fcc.gov/mb/policy; the Engineering Division's address is http://www.fcc.gov/mb/engineering; and the Industry Analysis Division's...

HTTP as a Data Access Protocol: Trials with XrootD in CMS’s AAA Project

NASA Astrophysics Data System (ADS)

Balcas, J.; Bockelman, B. P.; Kcira, D.; Newman, H.; Vlimant, J.; Hendricks, T. W.; CMS Collaboration

2017-10-01

The main goal of the project to demonstrate the ability of using HTTP data federations in a manner analogous to the existing AAA infrastructure of the CMS experiment. An initial testbed at Caltech has been built and changes in the CMS software (CMSSW) are being implemented in order to improve HTTP support. The testbed consists of a set of machines at the Caltech Tier2 that improve the support infrastructure for data federations at CMS. As a first step, we are building systems that produce and ingest network data transfers up to 80 Gbps. In collaboration with AAA, HTTP support is enabled at the US redirector and the Caltech testbed. A plugin for CMSSW is being developed for HTTP access based on the DaviX software. It will replace the present fork/exec or curl for HTTP access. In addition, extensions to the XRootD HTTP implementation are being developed to add functionality to it, such as client-based monitoring identifiers. In the future, patches will be developed to better integrate HTTP-over-XRootD with the Open Science Grid (OSG) distribution. First results of the transfer tests using HTTP are presented in this paper together with details about the initial setup.

48 CFR 52.211-2 - Availability of Specifications, Standards, and Data Item Descriptions Listed in the Acquisition...

Code of Federal Regulations, 2010 CFR

2010-10-01

... ASSIST websites: (1) ASSIST (http://assist.daps.dla.mil); (2) Quick Search (http://assist.daps.dla.mil/quicksearch); (3) ASSISTdocs.com (http://assistdocs.com). (b) Documents not available from ASSIST may be... Wizard (http://assist.daps.dla.mil/wizard); (2) Phoning the DoDSSP Customer Service Desk (215) 697-2179...

The Next Linear Collider Program

Science.gov Websites

/graphics.htm Snowmass 2001 http://snowmass2001.org/ Electrical Systems Modulators http://www -project.slac.stanford.edu/lc/local/electrical/e_home.htm DC Magnet Power http://www-project.slac.stanford.edu/lc/local /electrical/e_home.htm Global Systems http://www-project.slac.stanford.edu/lc/local/electrical/e_home.htm

48 CFR 52.211-2 - Availability of Specifications, Standards, and Data Item Descriptions Listed in the Acquisition...

Code of Federal Regulations, 2011 CFR

2011-10-01

... ASSIST websites: (1) ASSIST (http://assist.daps.dla.mil); (2) Quick Search (http://assist.daps.dla.mil/quicksearch); (3) ASSISTdocs.com (http://assistdocs.com). (b) Documents not available from ASSIST may be... Wizard (http://assist.daps.dla.mil/wizard); (2) Phoning the DoDSSP Customer Service Desk (215) 697-2179...

48 CFR 52.211-2 - Availability of Specifications, Standards, and Data Item Descriptions Listed in the Acquisition...

Code of Federal Regulations, 2013 CFR

2013-10-01

... ASSIST websites: (1) ASSIST (http://assist.daps.dla.mil); (2) Quick Search (http://assist.daps.dla.mil/quicksearch); (3) ASSISTdocs.com (http://assistdocs.com). (b) Documents not available from ASSIST may be... Wizard (http://assist.daps.dla.mil/wizard); (2) Phoning the DoDSSP Customer Service Desk (215) 697-2179...

48 CFR 52.211-2 - Availability of Specifications, Standards, and Data Item Descriptions Listed in the Acquisition...

Code of Federal Regulations, 2012 CFR

2012-10-01

... ASSIST websites: (1) ASSIST (http://assist.daps.dla.mil); (2) Quick Search (http://assist.daps.dla.mil/quicksearch); (3) ASSISTdocs.com (http://assistdocs.com). (b) Documents not available from ASSIST may be... Wizard (http://assist.daps.dla.mil/wizard); (2) Phoning the DoDSSP Customer Service Desk (215) 697-2179...

78 FR 3824 - Draft Qualitative Risk Assessment of Risk of Activity/Food Combinations for Activities (Outside...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-16

... available electronically at http://www.regulations.gov and at http://www.fda.gov/Food/ScienceResearch.... Available at: http://www.fda.gov/Food/ScienceResearch/ResearchAreas/RiskAssessmentSafetyAssessment/default...) Conducted in a Facility Co-Located on a Farm,'' 2012. Available at: http://www.fda.gov/ScienceResearch...

77 FR 58443 - Migratory Bird Hunting; Final Frameworks for Late-Season Migratory Bird Hunting Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-20

... address above, or from the Division of Migratory Bird Management's Web site at http://www.fws.gov... INFORMATION CONTACT or from our Web site at http://www.fws.gov/migratorybirds . Review of Public Comments and... http://www.regulations.gov , or from our Web site at http://www.fws.gov/migratorybirds/NewReports...

Does family-centred neonatal discharge planning reduce healthcare usage? A before and after study in South West England.

PubMed

Ingram, Jenny C; Powell, Jane E; Blair, Peter S; Pontin, David; Redshaw, Maggie; Manns, Sarah; Beasant, Lucy; Burden, Heather; Johnson, Debbie; Rose, Claire; Fleming, Peter J

2016-03-10

To implement parent-oriented discharge planning (Train-to-Home) for preterm infants in neonatal care. Before and after study, investigating the effects of the intervention during two 11-month periods before and after implementation. Four local neonatal units (LNUs) in South West England. Infants without major anomalies born at 27-33 weeks' gestation admitted to participating units, and their parents. A family-centred discharge package to increase parents' involvement and understanding of their baby's needs, comprising a train graphic and supporting care pathways to facilitate parents' understanding of their baby's progress and physiological maturation, combined with improved estimation of the likely discharge date. Perceived Maternal Parenting Self-Efficacy (PMP S-E) scores, infant length of stay (LOS) and healthcare utilisation for 8 weeks following discharge. Parents reported that the Train-to-Home improved understanding of their baby's progress and their preparedness for discharge. Despite a lack of change in PMP S-E scores with the intervention, the number of post-discharge visits to emergency departments (EDs) fell from 31 to 20 (p<0.05), with a significant reduction in associated healthcare costs (£3400 to £2200; p<0.05) after discharge. In both study phases, over 50% of infants went home more than 3 weeks before their estimated date of delivery (EDD), though no reduction in LOS occurred. Despite the lack of measurable effect on the parental self-efficacy scores, the reduction in ED attendances and associated costs supports the potential value of this approach. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Dismantling multicomponent behavioral treatment for insomnia in older adults: a randomized controlled trial.

PubMed

Epstein, Dana R; Sidani, Souraya; Bootzin, Richard R; Belyea, Michael J

2012-06-01

Recently, the use of multicomponent insomnia treatment has increased. This study compares the effect of single component and multicomponent behavioral treatments for insomnia in older adults after intervention and at 3 months and 1 yr posttreatment. A randomized, controlled study. Veterans Affairs medical center. 179 older adults (mean age, 68.9 yr ± 8.0; 115 women [64.2%]) with chronic primary insomnia. Participants were randomly assigned to 6 wk of stimulus control therapy (SCT), sleep restriction therapy (SRT), the 2 therapies combined into a multicomponent intervention (MCI), or a wait-list control group. Primary outcomes were subjective (daily sleep diary) and objective (actigraphy) measures of sleep-onset latency (SOL), wake after sleep onset (WASO), total sleep time (TST), time in bed (TIB), and sleep efficiency (SE). Secondary outcomes were clinical measures including response and remission rates. There were no differences between the single and multicomponent interventions on primary sleep outcomes measured by diary and actigraphy. All treatments produced significant improvement in diary-reported sleep in comparison with the control group. Effect sizes for sleep diary outcomes were medium to large. Treatment gains were maintained at follow-up for diary and actigraph measured SOL, WASO, and SE. The MCI group had the largest proportion of treatment remitters. For older adults with chronic primary insomnia, the findings provide initial evidence that SCT, SRT, and MCI are equally efficacious and produce sustainable treatment gains on diary, actigraphy, and clinical outcomes. From a clinical perspective, MCI may be a preferred treatment due to its higher remission rate. Behavioral Intervention for Insomnia in Older Adults. NCT01154023. URL: http://clinicaltrials.gov/ct2/show/NCT01154023?term=Behavioral+Intervention+for+Insomnia+in+Older+Adults&rank=1.

Explorative search of distributed bio-data to answer complex biomedical questions

PubMed Central

2014-01-01

Background The huge amount of biomedical-molecular data increasingly produced is providing scientists with potentially valuable information. Yet, such data quantity makes difficult to find and extract those data that are most reliable and most related to the biomedical questions to be answered, which are increasingly complex and often involve many different biomedical-molecular aspects. Such questions can be addressed only by comprehensively searching and exploring different types of data, which frequently are ordered and provided by different data sources. Search Computing has been proposed for the management and integration of ranked results from heterogeneous search services. Here, we present its novel application to the explorative search of distributed biomedical-molecular data and the integration of the search results to answer complex biomedical questions. Results A set of available bioinformatics search services has been modelled and registered in the Search Computing framework, and a Bioinformatics Search Computing application (Bio-SeCo) using such services has been created and made publicly available at http://www.bioinformatics.deib.polimi.it/bio-seco/seco/. It offers an integrated environment which eases search, exploration and ranking-aware combination of heterogeneous data provided by the available registered services, and supplies global results that can support answering complex multi-topic biomedical questions. Conclusions By using Bio-SeCo, scientists can explore the very large and very heterogeneous biomedical-molecular data available. They can easily make different explorative search attempts, inspect obtained results, select the most appropriate, expand or refine them and move forward and backward in the construction of a global complex biomedical query on multiple distributed sources that could eventually find the most relevant results. Thus, it provides an extremely useful automated support for exploratory integrated bio search, which is fundamental for Life Science data driven knowledge discovery. PMID:24564278

Effect of different exercise modalities plus a hypocaloric diet on inflammation markers in overweight patients: a randomised trial.

PubMed

Loria-Kohen, Viviana; Fernández-Fernández, Ceila; Bermejo, Laura M; Morencos, Esther; Romero-Moraleda, Blanca; Gómez-Candela, Carmen

2013-08-01

Inflammation markers (IM) have been associated with the development of chronic diseases. This study compares the effects on IM of three exercise programs combined with a hypocaloric diet. 119 overweight participants (73 women, 46 men) aged 18-50 years were randomised into four treatment groups: strength training (S; n = 30), endurance training (E; n = 30), combined S + E (SE; n = 30), and a diet and physical activity recommendations group (D; n = 29). Energy intake, anthropometric variables (AV), training variables (VO2peak, strength index, dynamometric strength index [DSI]) and plasma IM were recorded at baseline and after 22 weeks of treatment. 84 participants completed the study. At 22 weeks, all groups showed a significantly reduced energy intake (P < 0.001) and improved AV (P < 0.001). VO2peak significantly increased in all groups (P < 0.01). DSI increased in the exercise groups only (P < 0.05). Plasma leptin fell significantly (P < 0.001) in the S and E groups, but not significantly in the SE group (P = 0.029) (no significant differences between these groups). Tumour necrosis factor-α (TNF-α), and C-reactive protein (CRP) concentrations decreased in all groups when examined together, but not when examined separately. No significant differences were seen in interleukin-6 (IL-6). Combining strength or endurance training with a hypocaloric diet improved AV and reduced plasma leptin concentrations. No differences were seen between groups in terms of TNF-α, IL-6 or CRP reduction. This trial was registered at clinical trials.gov as NCT01116856. http://clinicaltrials.gov/. Copyright © 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Four-year visual outcomes after photorefractive keratectomy in pilots with low-moderate myopia.

PubMed

Moon, Chan Hee

2016-02-01

The photorefractive keratectomy (PRK) is approved for Air Force pilots in several nations. The occupational environments of pilots in the Air Force are unique, including extremely high altitude, low oxygen tension, high ultraviolet light exposure and high G-force load. The short-term efficacy and safety of PRK for pilots are documented. However, the study for long-term visual and refractive outcomes of PRK in pilots is limited. To investigate the long-term visual and refractive outcomes in a 4-year follow-up period after PRK in pilots with low to moderate myopia. Thirty-eight eyes of 20 subjects that underwent PRK and recruited to Air Force pilot were evaluated preoperatively and at 3, 6, 12, 24, and 48 months postoperatively. The mean patient age was 21.42±0.75 years. The mean preoperative manifest refraction spherical equivalent (SE) was -1.51±1.15 diopters (D). At 4 years postoperatively, the mean SE was -0.29±0.51, 89.5% of eyes achieved 20/20 or better Snellen uncorrected visual acuity, 71.1% of eyes were within ±0.50 D of emmetropia. The refraction stabilised by 6 months and was maintained up to the 4-year follow-up stage. PRK for pilots with low to moderate myopia is safe and effective in the long term. High-altitude environmental stress exposure has no effect on the refractive stability after PRK. ROKAF-ASMC-2015-IRB-002. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Tentacle: distributed quantification of genes in metagenomes.

PubMed

Boulund, Fredrik; Sjögren, Anders; Kristiansson, Erik

2015-01-01

In metagenomics, microbial communities are sequenced at increasingly high resolution, generating datasets with billions of DNA fragments. Novel methods that can efficiently process the growing volumes of sequence data are necessary for the accurate analysis and interpretation of existing and upcoming metagenomes. Here we present Tentacle, which is a novel framework that uses distributed computational resources for gene quantification in metagenomes. Tentacle is implemented using a dynamic master-worker approach in which DNA fragments are streamed via a network and processed in parallel on worker nodes. Tentacle is modular, extensible, and comes with support for six commonly used sequence aligners. It is easy to adapt Tentacle to different applications in metagenomics and easy to integrate into existing workflows. Evaluations show that Tentacle scales very well with increasing computing resources. We illustrate the versatility of Tentacle on three different use cases. Tentacle is written for Linux in Python 2.7 and is published as open source under the GNU General Public License (v3). Documentation, tutorials, installation instructions, and the source code are freely available online at: http://bioinformatics.math.chalmers.se/tentacle.

FunCoup 3.0: database of genome-wide functional coupling networks

PubMed Central

Schmitt, Thomas; Ogris, Christoph; Sonnhammer, Erik L. L.

2014-01-01

We present an update of the FunCoup database (http://FunCoup.sbc.su.se) of functional couplings, or functional associations, between genes and gene products. Identifying these functional couplings is an important step in the understanding of higher level mechanisms performed by complex cellular processes. FunCoup distinguishes between four classes of couplings: participation in the same signaling cascade, participation in the same metabolic process, co-membership in a protein complex and physical interaction. For each of these four classes, several types of experimental and statistical evidence are combined by Bayesian integration to predict genome-wide functional coupling networks. The FunCoup framework has been completely re-implemented to allow for more frequent future updates. It contains many improvements, such as a regularization procedure to automatically downweight redundant evidences and a novel method to incorporate phylogenetic profile similarity. Several datasets have been updated and new data have been added in FunCoup 3.0. Furthermore, we have developed a new Web site, which provides powerful tools to explore the predicted networks and to retrieve detailed information about the data underlying each prediction. PMID:24185702

A Five-Year Evolution of a Student-led Elective on Health Disparities at The Alpert Medical School.

PubMed

Leung, Lucinda B; Simmons, James E; Ho, Julius; Anselin, Emma; Yalamanchili, Rian; Rabatin, Joseph S

2016-10-04

Medical students are often unprepared for social challenges in caring for safety net patients. We aim to evaluate and chronicle the evolution of a pre-clinical elective alongside medical disparities curriculum. Medical students designed the course to supplement clinical training on care of vulnerable patients. From 2011-2015, there have been 80 first-year medical student participants, five cohorts of second-year course leaders, and two supporting faculty advisors for this 10-12 session evening elective. Students (n=67) rated the course extremely highly (ranging from 4.4-4.6 on a five-point Likert scale). Medical students reported having significantly more knowledge of underserved populations after taking the course (difference=0.72, SE=0.16, P <0.001). Career interests and attitudes toward health disparities remained strong after taking the course. This student-created elective equipped participants with improved knowledge in caring for underserved patients and contributed to the incorporation of health disparities in medical curriculum. [Full article available at http://rimed.org/rimedicaljournal-2016-10.asp].

NordicDB: a Nordic pool and portal for genome-wide control data.

PubMed

Leu, Monica; Humphreys, Keith; Surakka, Ida; Rehnberg, Emil; Muilu, Juha; Rosenström, Päivi; Almgren, Peter; Jääskeläinen, Juha; Lifton, Richard P; Kyvik, Kirsten Ohm; Kaprio, Jaakko; Pedersen, Nancy L; Palotie, Aarno; Hall, Per; Grönberg, Henrik; Groop, Leif; Peltonen, Leena; Palmgren, Juni; Ripatti, Samuli

2010-12-01

A cost-efficient way to increase power in a genetic association study is to pool controls from different sources. The genotyping effort can then be directed to large case series. The Nordic Control database, NordicDB, has been set up as a unique resource in the Nordic area and the data are available for authorized users through the web portal (http://www.nordicdb.org). The current version of NordicDB pools together high-density genome-wide SNP information from ∼5000 controls originating from Finnish, Swedish and Danish studies and shows country-specific allele frequencies for SNP markers. The genetic homogeneity of the samples was investigated using multidimensional scaling (MDS) analysis and pairwise allele frequency differences between the studies. The plot of the first two MDS components showed excellent resemblance to the geographical placement of the samples, with a clear NW-SE gradient. We advise researchers to assess the impact of population structure when incorporating NordicDB controls in association studies. This harmonized Nordic database presents a unique genome-wide resource for future genetic association studies in the Nordic countries.

FunCoup 3.0: database of genome-wide functional coupling networks.

PubMed

Schmitt, Thomas; Ogris, Christoph; Sonnhammer, Erik L L

2014-01-01

We present an update of the FunCoup database (http://FunCoup.sbc.su.se) of functional couplings, or functional associations, between genes and gene products. Identifying these functional couplings is an important step in the understanding of higher level mechanisms performed by complex cellular processes. FunCoup distinguishes between four classes of couplings: participation in the same signaling cascade, participation in the same metabolic process, co-membership in a protein complex and physical interaction. For each of these four classes, several types of experimental and statistical evidence are combined by Bayesian integration to predict genome-wide functional coupling networks. The FunCoup framework has been completely re-implemented to allow for more frequent future updates. It contains many improvements, such as a regularization procedure to automatically downweight redundant evidences and a novel method to incorporate phylogenetic profile similarity. Several datasets have been updated and new data have been added in FunCoup 3.0. Furthermore, we have developed a new Web site, which provides powerful tools to explore the predicted networks and to retrieve detailed information about the data underlying each prediction.

NordicDB: a Nordic pool and portal for genome-wide control data

PubMed Central

Leu, Monica; Humphreys, Keith; Surakka, Ida; Rehnberg, Emil; Muilu, Juha; Rosenström, Päivi; Almgren, Peter; Jääskeläinen, Juha; Lifton, Richard P; Kyvik, Kirsten Ohm; Kaprio, Jaakko; Pedersen, Nancy L; Palotie, Aarno; Hall, Per; Grönberg, Henrik; Groop, Leif; Peltonen, Leena; Palmgren, Juni; Ripatti, Samuli

2010-01-01

A cost-efficient way to increase power in a genetic association study is to pool controls from different sources. The genotyping effort can then be directed to large case series. The Nordic Control database, NordicDB, has been set up as a unique resource in the Nordic area and the data are available for authorized users through the web portal (http://www.nordicdb.org). The current version of NordicDB pools together high-density genome-wide SNP information from ∼5000 controls originating from Finnish, Swedish and Danish studies and shows country-specific allele frequencies for SNP markers. The genetic homogeneity of the samples was investigated using multidimensional scaling (MDS) analysis and pairwise allele frequency differences between the studies. The plot of the first two MDS components showed excellent resemblance to the geographical placement of the samples, with a clear NW–SE gradient. We advise researchers to assess the impact of population structure when incorporating NordicDB controls in association studies. This harmonized Nordic database presents a unique genome-wide resource for future genetic association studies in the Nordic countries. PMID:20664631

75 FR 65503 - Notice of Availability: Notice of Funding Availability (NOFA) for Fiscal Year (FY) 2010 Continuum...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-25

.... ACTION: Notice of technical correction. SUMMARY: On September 20, 2010, HUD posted on http://www.Grants.gov and http://www.hudhre.info its Notice of Funding Availability (NOFA) for HUD's FY2010 Continuum of... http://www.Grants.gov and http://www.hudhre.info a technical correction that corrects Appendix A of the...

The Emerging Infrastructure of Autonomous Astronomy

NASA Astrophysics Data System (ADS)

Seaman, R.; Allan, A.; Axelrod, T.; Cook, K.; White, R.; Williams, R.

2007-10-01

Advances in the understanding of cosmic processes demand that sky transient events be confronted with statistical techniques honed on static phenomena. Time domain data sets require vast surveys such as LSST {http://www.lsst.org/lsst_home.shtml} and Pan-STARRS {http://www.pan-starrs.ifa.hawaii.edu}. A new autonomous infrastructure must close the loop from the scheduling of survey observations, through data archiving and pipeline processing, to the publication of transient event alerts and automated follow-up, and to the easy analysis of resulting data. The IVOA VOEvent {http://voevent.org} working group leads efforts to characterize sky transient alerts published through VOEventNet {http://voeventnet.org}. The Heterogeneous Telescope Networks (HTN {http://www.telescope-networks.org}) consortium are observatories and robotic telescope projects seeking interoperability with a long-term goal of creating an e-market for telescope time. Two projects relying on VOEvent and HTN are eSTAR {http://www.estar.org.uk} and the Thinking Telescope {http://www.thinkingtelescopes.lanl.gov} Project.

Irish Team Wins SEA & SPACE Super Prize

NASA Astrophysics Data System (ADS)

1998-09-01

A secondary school team from Ireland has won a trip to Europe's Spaceport in Kourou, French Guyana, and to ESO's Very Large Telescope (VLT) at Cerro Paranal, Chile. The trip is the Super-Prize for the Sea & Space Newspaper Competition , organised within the framework of the European Week for Scientific and Technological Culture. ESO PR Photo 33/98 ESO PR Photo 33/98 [Preview - JPEG: 800 x 434 pix - 568k] [High-Res - JPEG: 3000 x 1627 pix - 6.7Mb] The presentation of prize certificates to the winning Irish team (right) in Lisbon, on August 31, 1998, by ESO, ESA and EAAE representatives. Stephen Kearney, Cian Wilson (both aged 16 years), Eamonn McKeogh (aged 17 years) together with their teacher, John Daly of Blackrock College in Dublin, prepared their newspaper, Infinitus , on marine and space themes, and came first in the national round of the competition. Together with other students from all over Europe, they were invited to present their winning newspaper to a jury consisting of representatives of the organisers, during a special programme of events at the Gulbenkian Planetarium and EXPO '98 in Lisbon, from 28-31 August, 1998. The Irish team scored highly in all categories of the judging, which included scientific content and originality and creativity of the articles. Their look at Irish contributions to sea and space research also proved popular in a ballot by fellow student competitors. This vote was also taken into account by the judges. The jury was very impressed by the high quality of the national entries and there were several close runners-up. The width and depth was amazing and the variety of ideas and formats presented by the sixteen teams was enormous. A poster competition was organised for younger students, aged 10 to 13 and winning entries at national level are on display at the Oceanophilia Pavilion at EXPO '98. The SEA & SPACE project is a joint initiative of the European Space Agency (ESA) , the European Southern Observatory (ESO) , and the European Association for Astronomy Education (EAAE) , in cooperation with the German National Research Centre for Information Technology (GMD). It builds on these organisations' several years' successful participation in the European Week for Scientific and Technological Culture organised by the European Commission . Note: [1] This press release is published jointly by ESA, ESO and EAAE. More information about the background of SEA & SPACE is available in ESO PR 02/98 (January 22, 1998) and ESA Press Release N 03-98 (23 January 1998). SEA & SPACE webpages are available at these URL's: * http://www.esrin.esa.int/seaspace * http://www.eso.org/seaspace , and * http://www.algonet.se/~sirius/eaae/seaspace How to obtain ESO Press Information ESO Press Information is made available on the World-Wide Web (URL: http://www.eso.org ). ESO Press Photos may be reproduced, if credit is given to the European Southern Observatory.

Wheezing

MedlinePlus

... in adults. http://www.uptodate.com/home. Accessed March 24, 2017. Oo S, et al. The wheezing child: An ... Elsevier Saunders; 2017. http://www.clinicalkey.com. Accessed March 24, 2017. Wheezing. Merck Manual Professional Version. http://www. ...

Fine Scale Modeling and Forecasts of Upper Atmospheric Turbulence for Operational Use

DTIC Science & Technology

2014-11-30

Weather Center Digital Data Service (ADDS) fhttp://www.aviationweather.gov/adds, http://weather.aero/1 Graphical Turbulence Guidance product, GTG -2.5...analysis GTG - Graphical Turbulence Guidance HRMM - High Resolution Mesoscale/Microscale ICD - Interface Control Document IDE - Integrated Development...site (with GTG 2.5 data) http://www.aviationweather.gov/turbuience • ADDS Experimental site http://weather.aero/ • NCEP FNL data - http

47 CFR 0.441 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... information and general inquiries may be submitted by: (1) Internet at http://www.fcc.gov/cgb/fccinfo or http... in resolving any concerns related to a Freedom of Information Act request. See http://www.fcc.gov...

D-dimer Test

MedlinePlus

... http://www.beckmancoulter.com . Began, T. (2002 October). Elisa D-Dimer: How Accurate For PE Diagnosis? PulmonaryReviews. ... at http://www.pulmonaryreviews.com/oct02/pr_oct02_ELISA.html through http://www.pulmonaryreviews.com . Cortese Hassett, ...

Sexual Assaults in the Marine Corps: Really Increasing?

DTIC Science & Technology

2013-04-11

local law enforcement the following: rape, spousal rape, sodomy, oral copulation, sexual penetration, sexual banerv~ Incest , procurtng any female to...DoD)
 http://www.sapro.mil SAPR Website (USMC)
 www.manpower.usmc.mil/SAPR Rape, Abuse & Incest National Network http://www.rainn.org Office...Against Women: http://www.ovw.usdoj.gov/sexassault.htm National Sexual Violence Resources Center 
 http://www.nsvrc.org Rape Abuse Incest

48 CFR 2901.603-1 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... available at: http://www.arnet.gov/Library/OFPP/PolicyLetters/Letters/PL97-01.html, http://www.arnet.gov...: http://www.faionline.com/fai/campus/index4.htm. (b) The program must cover all contracting personnel in...

48 CFR 2901.603-1 - General.

Code of Federal Regulations, 2012 CFR

2012-10-01

... available at: http://www.arnet.gov/Library/OFPP/PolicyLetters/Letters/PL97-01.html, http://www.arnet.gov...: http://www.faionline.com/fai/campus/index4.htm. (b) The program must cover all contracting personnel in...

48 CFR 2901.603-1 - General.

Code of Federal Regulations, 2013 CFR

2013-10-01

... available at: http://www.arnet.gov/Library/OFPP/PolicyLetters/Letters/PL97-01.html, http://www.arnet.gov...: http://www.faionline.com/fai/campus/index4.htm. (b) The program must cover all contracting personnel in...

48 CFR 2901.603-1 - General.

Code of Federal Regulations, 2014 CFR

2014-10-01

... available at: http://www.arnet.gov/Library/OFPP/PolicyLetters/Letters/PL97-01.html, http://www.arnet.gov...: http://www.faionline.com/fai/campus/index4.htm. (b) The program must cover all contracting personnel in...

Communication with Your Family and Your Doctor about Your Wishes

MedlinePlus

... close to the end of your life. References: http://www.aarp.org/families/end_life/ http://www.nlm.nih.gov/medlineplus/endoflifeissues.html http://agnewsarchive.tamu.edu/dailynews/stories/CFAM/Sep0407a.htm ...

Cuba After Castro: Implications of Change

DTIC Science & Technology

2005-03-18

Down,” Hoover Digest, 3 Summer 2004, available from <http://www.hooverdigest.org/030/ratliff.html>; Internet; accessed 07 January 2005. 39 Edward ...http://usembassy.state.gov/havana/wwwhc1109sp.html>; Internet; accessed 15 January 2005. 49 Vanessa Bauza, “Cuba Mill Closures,” available from <http...Lives, U.N. Report Says.” Available from <http://japan.usembassy.gov/e/p/tp-20041209-20.html>. Internet. Accessed 01 February 2005. Bauza, Vanessa

The Management of Ethnic-Cultural Diversity in Western Armed Forces

DTIC Science & Technology

2012-03-20

192-201. 12 Bruce A. Brant, ―Vanguard of Social Change?‖ Military Review, no. 73 (February 1993): 12-19. 13 Histoire du monde Home Page, http...11, 2008. http://inde.aujourdhuilemonde.com/les-separatistes-gorkhas-entament-un-blocus- general?page=7 (accessed January 25, 2012). 15 ― Histoire ...du monde Home Page, http://www.histoiredumonde.net/Gurkhas.html (accessed January 25, 2012). 16 Histoire du monde Home Page, http

Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85.

PubMed

Kedar, Vishram P; Darby, Martyn K; Williams, Jason G; Blackshear, Perry J

2010-03-08

Tristetraprolin (TTP) is the prototype member of a family of CCCH tandem zinc finger proteins and is considered to be an anti-inflammatory protein in mammals. TTP plays a critical role in the decay of tumor necrosis factor alpha (TNF) mRNA, among others, by binding AU-rich RNA elements in the 3'-untranslated regions of this transcript and promoting its deadenylation and degradation. We used yeast two-hybrid analysis to identify potential protein binding partners for human TTP (hTTP). Various regions of hTTP recovered 31 proteins that fell into 12 categories based on sequence similarities. Among these, the interactions between hTTP and CIN85, cytoplasmic poly (A) binding protein (PABP), nucleolin and heat shock protein 70 were confirmed by co-immunoprecipitation experiments. CIN85 and hTTP co-localized in the cytoplasm of cells as determined by confocal microscopy. CIN85 contains three SH3 domains that specifically bind a unique proline-arginine motif (PXXXPR) found in several CIN85 effectors. We found that the SH3 domains of CIN85 bound to a PXXXPR motif located near the C-terminus of hTTP. Co-expression of CIN85 with hTTP resulted in the increased phosphorylation of hTTP at serine residues in positions 66 and 93, possibly due in part to the demonstrated association of mitogen-activated protein kinase kinase kinase 4 (MEKK4) to both proteins. The presence of CIN85 did not appear to alter hTTP's binding to RNA probes or its stimulated breakdown of TNF mRNA. These studies describe interactions between hTTP and nucleolin, cytoplasmic PABP, heat shock protein 70 and CIN85; these interactions were initially discovered by two-hybrid analysis, and confirmed by co-immunoprecipitation. We found that CIN85 binding to a C-terminal motif within hTTP led to the increased phosphorylation of hTTP, possibly through enhanced association with MEKK4. The functional consequences to each of the members of this putative complex remain to be determined.

48 CFR 752.7019 - Participant training.

Code of Federal Regulations, 2010 CFR

2010-10-01

... contract. The current version of Chapter 253 may be obtained directly from the USAID website at http://www... Agency. The website for academic programs is: http://www.iie.org/fulbright/posts/restrict. U.S.-based... (website: http://policyworks.gov). [64 FR 5011, Feb. 2, 1999] ...

User Manual for IDA Reading Guide Website Visitors

DTIC Science & Technology

2012-01-01

modules. The most important module is called Biblio , which enables the display of bibliographic information. Other modules of special importance are... Biblio : http://drupal.org/project/ biblio • Apache Solr: http://drupal.org/project/apachesolr • Glossary: http://drupal.org/project/glossary

48 CFR 752.7019 - Participant training.

Code of Federal Regulations, 2014 CFR

2014-10-01

... contract. The current version of Chapter 253 may be obtained directly from the USAID website at http://www... Agency. The website for academic programs is: http://www.iie.org/fulbright/posts/restrict. U.S.-based... (website: http://policyworks.gov). [64 FR 5011, Feb. 2, 1999] ...

48 CFR 752.7019 - Participant training.

Code of Federal Regulations, 2013 CFR

2013-10-01

... contract. The current version of Chapter 253 may be obtained directly from the USAID website at http://www... Agency. The website for academic programs is: http://www.iie.org/fulbright/posts/restrict. U.S.-based... (website: http://policyworks.gov). [64 FR 5011, Feb. 2, 1999] ...

48 CFR 752.7019 - Participant training.

Code of Federal Regulations, 2012 CFR

2012-10-01

... contract. The current version of Chapter 253 may be obtained directly from the USAID website at http://www... Agency. The website for academic programs is: http://www.iie.org/fulbright/posts/restrict. U.S.-based... (website: http://policyworks.gov). [64 FR 5011, Feb. 2, 1999] ...

Improving throughput and user experience for information intensive websites by applying HTTP compression technique.

PubMed

Malla, Ratnakar

2008-11-06

HTTP compression is a technique specified as part of the W3C HTTP 1.0 standard. It allows HTTP servers to take advantage of GZIP compression technology that is built into latest browsers. A brief survey of medical informatics websites show that compression is not enabled. With compression enabled, downloaded files sizes are reduced by more than 50% and typical transaction time is also reduced from 20 to 8 minutes, thus providing a better user experience.

HR Public meeting

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heuer, Rolf; Catherin, Anne-Sylvie; Vuillemin, Vin

2010-06-25

Cher(e)s collègues, En collaboration avec le Département HR, le Directeur général a le plaisir de vous convier à une réunion publique qui se tiendra le vendredi 25 juin 2010 à 9h30 dans l’Amphithéâtre principal (Bâtiment 500)*. Un café d’accueil y sera servi à partir de 9h. Cette réunion abordera les thèmes suivants : • Valeurs de l’Organisation (Directeur général) • Code de Conduite (Directeur général / Anne-Sylvie Catherin) • Création du nouveau rôle d’Ombudsperson (Vincent Vuillemin); Ces présentations seront suivies d’une séance de questions-réponses. Nous espérons vous retrouver nombreux le 25 juin ! Meilleures salutations, Anne-Sylvie Catherin Chef du Départementmore » des Ressources humaines *Cette réunion sera retransmise simultanément dans l’Amphithéâtre BE de Prévessin (Bâtiment 864) et également disponible à l’adresse suivante : http://webcast.cern.ch. Dear colleagues, In collaboration with HR Department, the Director-General would like to invite you to an information meeting which will be held on Friday 25 June 2010 at 9:30 am in the Main Auditorium (Building 500)*. A welcome coffee will be available from 9:00 am. During this meeting, information will be given about: • Organization’s values (Director-General) • Code of Conduct (Director-General / Anne-Sylvie Catherin) • New Ombudsperson role (Vincent Vuillemin) These presentations will be followed by a questions & answers session. We look forward to seeing you all on 25 June! Best regards, Anne-Sylvie Catherin Head, Human Resources Department. This meeting will be simultaneously retransmitted in BE Auditorium (Building 864) and available at the following address: http://webcast.cern.ch.« less

HR Public meeting

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2010-10-12

Cher(e)s collègues, En collaboration avec le Département HR, le Directeur général a le plaisir de vous convier à une réunion publique qui se tiendra le vendredi 25 juin 2010 à 9h30 dans l’Amphithéâtre principal (Bâtiment 500)*. Un café d’accueil y sera servi à partir de 9h. Cette réunion abordera les thèmes suivants : Valeurs de l’Organisation (Directeur général); Code de Conduite (Directeur général / Anne-Sylvie Catherin); Création du nouveau rôle d’Ombudsperson (Vincent Vuillemin) Ces présentations seront suivies d’une séance de questions-réponses. Nous espérons vous retrouver nombreux le 25 juin ! Meilleures salutations, Anne-Sylvie Catherin Chef du Département des Ressources humainesmore » *Cette réunion sera retransmise simultanément dans l’Amphithéâtre BE de Prévessin (Bâtiment 864) et également disponible à l’adresse suivante : http://webcast.cern.ch [Dear colleagues, In collaboration with HR Department, the Director-General would like to invite you to an information meeting which will be held on Friday 25 June 2010 at 9:30 am in the Main Auditorium (Building 500)*. A welcome coffee will be available from 9:00 am. During this meeting, information will be given about: Organization’s values (Director-General); Code of Conduct (Director-General / Anne-Sylvie Catherin); New Ombudsperson role (Vincent Vuillemin); These presentations will be followed by a questions & answers session. We look forward to seeing you all on 25 June! Best regards, Anne-Sylvie Catherin Head, Human Resources Department *This meeting will be simultaneously retransmitted in BE Auditorium (Building 864) and available at the following address: http://webcast.cern.ch.« less

Promoting Physical Activity in Low-Active Adolescents via Facebook: A Pilot Randomized Controlled Trial to Test Feasibility.

PubMed

Wójcicki, Thomas R; Grigsby-Toussaint, Diana; Hillman, Charles H; Huhman, Marian; McAuley, Edward

2014-10-30

The World Wide Web is an effective method for delivering health behavior programs, yet major limitations remain (eg, cost of development, time and resource requirements, limited interactivity). Social media, however, has the potential to deliver highly customizable and socially interactive behavioral interventions with fewer constraints. Thus, the evaluation of social media as a means to influence health behaviors is warranted. The objective of this trial was to examine and demonstrate the feasibility of using an established social networking platform (ie, Facebook) to deliver an 8 week physical activity intervention to a sample of low-active adolescents (N=21; estimated marginal mean age 13.48 years). Participants were randomized to either an experimental (ie, Behavioral) or attentional control (ie, Informational) condition. Both conditions received access to a restricted-access, study-specific Facebook group where the group's administrator made two daily wall posts containing youth-based physical activity information and resources. Primary outcomes included physical activity as assessed by accelerometry and self-report. Interactions and main effects were examined, as well as mean differences in effect sizes. Analyses revealed significant improvements over time on subjectively reported weekly leisure-time physical activity (F1,18=8.426, P=.009, η2 = .319). However, there was no interaction between time and condition (F1,18=0.002, P=.968, η2 = .000). There were no significant time or interaction effects among the objectively measured physical activity variables. Examination of effect sizes revealed moderate-to-large changes in physical activity outcomes. Results provide initial support for the feasibility of delivery of a physical activity intervention to low-active adolescents via social media. Whether by employing behavioral interventions via social media can result in statistically meaningful changes in health-related behaviors and outcomes remains to be determined. ClinicalTrials.gov NCT01870323; http://clinicaltrials.gov/show/NCT01870323 (Archived by WebCite at http://www.webcitation.org/6SUTmSeZZ).

77 FR 47084 - Changes in Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-07

... of http:// August 6, 2012....... 210067 Fayette Urban Gray, Mayor, Planning, Current www.bakeraecom... Oxnard (12- The Honorable Planning http:// August 6, 2012....... 060417 09-1132P) Thomas E. Holden... Department of http:// July 13, 2012........ 080087 areas of Jefferson Donald Rosier, Planning and www...

48 CFR 5.601 - Governmentwide database of contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... intended for use by multiple agencies is available via the Internet at http://www.contractdirectory.gov...) Enter the information specified at http://www.contractdirectory.gov, in accordance with the instructions... contracts. (2) Enter the information specified at http://www.contractdirectory.gov in accordance with the...

Biogeography of key mesozooplankton species in the North Atlantic, by manual counting methods, and egg production of Calanus finmarchicus

NASA Astrophysics Data System (ADS)

Melle, W.; Runge, J. A.; Head, E.; Plourde, S.; Castellani, C.; Licandro, P.; Pierson, J.; Jonasdottir, S. H.; Johnson, C.; Broms, C.; Debes, H.; Falkenhaug, T.; Gaard, E.; Gislason, A.; Heath, M. R.; Niehoff, B.; Nielsen, T. G.; Pepin, P.; Stenevik, E. K.; Chust, G.

2014-04-01

Here we present a new, pan-Atlantic compilation of data on key mesozooplankton species, including the possibly most important copepod, Calanus finmarchicus. Distributional data of ten representative zooplankton taxa, from recent (2000-2009) Continuous Plankton Recorder data, are presented, along with basin-scale data of the phytoplankton colour index. Then we present a compilation of data on C. finmarchicus including observations of abundance, demography, egg production and female size with accompanying data on temperature and chlorophyll. This is a contribution by Canadian, European and US scientists and their institutions. http://doi.pangaea.de/10.1594/PANGAEA.820732, http://doi.pangaea.de/10.1594/PANGAEA.824423, http://doi.pangaea.de/10.1594/PANGAEA.828393.

Ocean-color remote sensing of the Nile delta shelf and SE Levantine basin and possible linkage to some mesoscale circulation features and Nile river run-off

NASA Astrophysics Data System (ADS)

Moufaddal, Wahid; Lavender, Samantha

To date, and despite the passage of more than 30 years since the launch of the first satellite based ocean-color sensor, no systematic study of the variability of chlorophyll in the Egyptian Mediterranean coast off the Nile delta has been undertaken using this kind of data. Meantime, available in-situ measurements on chlorophyll and other nutrient parameters along this coast are indeed very modest and scarce. The lack of data has in turn created a large gap in our knowledge on the biogeochemical characteristics of the coastal water and impacts of the Aswan High Dam and other land-use changes on the marine ecosystems and nutrient budget in the Nile delta shelf and the SE Mediterranean. The present study aims to fill part of this gap through application of ocean-color remote sensing and satellite retrieval of phytoplankton chlorophyll. For this purpose a 10-year (1997-2006) monthly satellite dataset from ESA Globcolour project (an ESA Data User Element project: http://www.globcolour.info) was retrieved and subjected to time-series analysis. Results of this analysis revealed that the oceanic and coastal parts off the Nile delta coast and SE Mediterranean manifest from time to time some of the most interesting and dynamical marine features including meso-scale gyres, coastal filaments, localized algal blooms and higher concentration of phytoplankton chlorophyll. These features together with certain physical pro-cesses and surface run-off from Nile mouthes and other land-based sources were found to exert pronounced effects on the nutrient supply and quality of the coastal and oceanic surface waters in this region. Results reveled also that there has been a general upward trend in concentration of surface chlorophyll during the 10-year period from 1997 to 2006 with a coincident rise of the coastal fisheries implying that improvement of nutrient supply is most likely responsible for this rise. Results confirmed also shift of the Nile phytoplankton bloom in space and time after construc-tion of the Aswan High Dam and other subsequent anthropogenic activities Conclusions and results achieved by this study show the importance of ocean-color satellite data for monitoring of biogeochemical impacts of land-use changes on coastal ecosystems and the role which it can play in assessment of the marine productivity and state of the marine fisheries.

Nuclear Data on the WWW

NASA Astrophysics Data System (ADS)

Firestone, Richard B.; Chu, S. Y. Frank; Ekstrom, L. Peter; Wu, Shiu-Chin; Singh, Balraj

1997-10-01

The Isotopes Project is developing Internet home pages to provide data for radioactive decay, nuclear structure, nuclear astrophysics, spontaneous fission, thermal neutron capture, and atomic masses. These home pages can be accessed from the Table of Isotopes home page at http://isotopes.lbl.gov/isotopes/toi.html. Data from the Evaluated Nuclear Structure Data File (ENSDF) is now available on the WWW in Nuclear Data Sheet style tables, complete with comments and hypertext linked footnotes. Bibliographic information from the Nuclear Science Reference (NSR) file can be searched on the WWW by combinations of author, A, Z, reaction, and various keywords. Decay gamma-ray data from several databases can be searched by energy. The Table of Superdeformed Nuclear Bands and Fission Isomers is continously updated. Reaction rates from Hoffman and Woosley and from Thielemann, fission yields from England and Rider, thermal neutron cross-sections from BNL-325, atomic masses from Audi, and skeleton scheme drawings and nuclear charts from the Table of Isotopes are among the information available through these websites. The nuclear data home pages are accessed by over 3500 different users each month.

33 CFR 1.05-25 - Public docket.

Code of Federal Regulations, 2010 CFR

2010-07-01

... docket. Public dockets for Coast Guard rulemakings are available electronically at http://www.regulations... http://www.regulations.gov. Paragraph (a) of this section describes how to access and view these... available for inspection at the appropriate Captains of the Port Office or online at http://www.regulations...

75 FR 36015 - Uniformed Services Accounts and Death Benefits; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-24

... http://www.regulations.gov , by mail, by hand deliver/courier, or by facsimile. FOR FURTHER INFORMATION...: Federal Rulemaking Portal: http://www.regulations.gov . Follow the instructions for submitting comments... the exception of redaction of SSNs, profanities, et cetera) on http://www.regulations.gov .'' Dated...

Program Manager - A Bimonthly Magazine of DSMC, Volume 27, Number 2.

DTIC Science & Technology

1998-04-01

catalog. http /www.gsa.gov -------------- - Online shopping for commercial items to http ’Iwww.ndia.org I--- support government interests. Events...funds. Allows users access to GAO "Whats New in Contracting?" educational reports, FAQs. products catalog. http://www.gsa.gov Online shopping for

The Case for Spacecrime: The Rise of Crime and Piracy in the Space Domain

DTIC Science & Technology

2013-06-01

resulted in generally outdated hardware with limited capabilities.21 More recent hardware platforms such as Arduino, BeagleBone, Raspberry Pi and others...www.citizensinspace.org; Arduino platform, http://www.arduino.cc; Beaglebone platform, http://www.beagleboard.org; Raspberry Pi platform, http

14 CFR 1260.9 - Synopses requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... opportunities shall be synopsized. Synopses shall be prepared in the NASA Acquisition Internet Service (NAIS), located at: http://prod.nais.nasa.gov/cgi-bin/nais/index.cgi; by using the Electronic Posting System (EPS), and transmitted to http://www.Fedgrants.gov. Synopses shall be electronically posted to: http://www...

46 CFR 148.8 - Incorporation by reference.

Code of Federal Regulations, 2011 CFR

2011-10-01

... http://www.archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html. Also, it is... 7611, http://www.imo.org. (1) International Maritime Solid Bulk Cargoes Code and Supplement, 2009..., New York, NY 10017, (800) 253-9646, http://unp.un.org. (1) Recommendations on the Transport of...

32 CFR 108.2 - Applicability.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Internet at http://www.dtic.mil/whs/directives/corres/pdf/300005p.pdf. 2 Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/220502p.pdf. 3 Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/231008p.pdf. ...

32 CFR 108.2 - Applicability.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Internet at http://www.dtic.mil/whs/directives/corres/pdf/300005p.pdf. 2 Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/220502p.pdf. 3 Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/231008p.pdf. ...

32 CFR 108.2 - Applicability.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Internet at http://www.dtic.mil/whs/directives/corres/pdf/300005p.pdf. 2 Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/220502p.pdf. 3 Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/231008p.pdf. ...

48 CFR 8.402 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... System.) Ordering activities may access GSA Advantage! through the GSA Federal Supply Service Home Page (http://www.gsa.gov/fss) or the GSA Federal Supply Schedule Home Page at http://www.gsa.gov/schedules..., review the following Web site: http://www.gsa.gov/schedules. Additionally, for on-line training courses...

77 FR 8818 - Publication of FY 2011 Service Contract Inventory

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

... the inventory on the Bureau's Open Government homepage at the following link: http://www.consumerfinance.gov/open/ , specifically at http://www.consumerfinance.gov/wp-content/uploads/2012/01/Appendix-C-FY2011-Inventory-Data-Summary.pdf and http://www.consumerfinance.gov/wp-content/uploads/2012/01/Appendix...

14 CFR 1260.9 - Synopses requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Service (NAIS), located at: http://prod.nais.nasa.gov/cgi-bin/nais/index.cgi; by using the Electronic Posting System (EPS), and transmitted to http://www.Fedgrants.gov. Synopses shall be electronically posted to: http://www.Fedgrants.gov no later than three business days after release of the full announcement...

75 FR 40857 - Webinar About Advanced Defense Technologies RFP

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-14

... Defense Technologies RFP. Please visit http://www.sba.gov/clusters/index.html for more information. The RFP may be found on http://www.fedbizopps.gov . LOGISTICAL INFORMATION: The webinar will be held on Monday, July 19, 2010. For details, please visit http://www.sba.gov/clusters/index.html . SUPPLEMENTARY...

48 CFR 1201.105-3 - Copies.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Office, Washington, DC 20402. The electronic version of the Federal Register may be found at http://www.nara.gov and the CFR at http://www.gpoaccess.gov. (b) The (TAR) 48 CFR chapter 12 and Transportation Acquisition Circulars (TACs) are available on the Internet at http://www.dot.gov/ost/m60. ...

32 CFR 701.102 - Online resources.

Code of Federal Regulations, 2010 CFR

2010-07-01

... online Web site (http://www.privacy.navy.mil). This Web site supplements this subpart and subpart G. It...) Web site (http://www.doncio.navy.mil). This Web site provides detailed guidance on PIAs. (c) DOD's PA Web site (http://www.defenselink.mil/privacy). This Web site is an excellent resource that contains a...

A Few New Things

ERIC Educational Resources Information Center

Valenza, Joyce Kasman

2008-01-01

Citing the website "43 Things" (http://www.43things.com/) and derivatives Learning 2.0 (http://plcmcl2-about.blogspot.com/) and California's School Library Learning 2.0 (http://www.schoollibrarylearning2.blogspot.com/), the author suggests other activities to help librarians and teacher-librarians train themselves for leadership in new information…

76 FR 38585 - Proposed Establishment of Class E Airspace; Wilkes-Barre, PA

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-01

... may also submit and review received comments through the Internet at http:[sol][sol]www.regulations... submit comments through the Internet at http:[sol][sol]www.regulations.gov. Annotators wishing the FAA to... downloaded from and comments submitted through http:[sol][sol]www.regulations.gov. Recently published...

78 FR 32212 - Proposed Amendment of Class E Airspace; Factoryville, PA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-29

... received comments through the Internet at http:[sol][sol]www.regulations.gov. FOR FURTHER INFORMATION... comments through the Internet at http:[sol][sol]www.regulations.gov. Persons wishing the FAA to acknowledge... from and comments submitted through http:[sol][sol]www.regulations.gov. Recently published rulemaking...

75 FR 62024 - Metal and Nonmetal Dams

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-07

... the following methods: (1) Federal Rulemaking Portal: http:[sol][sol]www.regulations.gov. Follow the... receptionist's desk on the 21st floor. (6) Docket: Comments can be accessed electronically at http:[sol][sol... publishes rulemaking documents in the Federal Register. To subscribe, go to http:[sol][sol]www.msha.gov...

76 FR 52297 - Defense Federal Acquisition Regulation Supplement; Safeguarding Unclassified DoD Information

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-22

...: http:[sol][sol]www.regulations.gov. Follow the instructions for submitting comments. [cir] E-mail... without change to http:[sol][sol]www.regulations.gov, including any personal information provided. To confirm receipt of your comment, please check http:[sol][sol]www.regulations.gov approximately two to...

48 CFR 3001.105-3 - Copies.

Code of Federal Regulations, 2014 CFR

2014-10-01

... http://www.dhs.gov. A convenient but unofficial up-to-date version of the HSAR is also available from the Government Printing office at http://www.gpoaccess.gov/ecfr/index.html. The Homeland Security Acquisition Manual (HSAM), which complements the HSAR, can also be found at http://www.dhs.gov. [77 FR 50632...

48 CFR 3001.105-3 - Copies.

Code of Federal Regulations, 2012 CFR

2012-10-01

... http://www.dhs.gov. A convenient but unofficial up-to-date version of the HSAR is also available from the Government Printing office at http://www.gpoaccess.gov/ecfr/index.html. The Homeland Security Acquisition Manual (HSAM), which complements the HSAR, can also be found at http://www.dhs.gov. [77 FR 50632...

48 CFR 3001.105-3 - Copies.

Code of Federal Regulations, 2013 CFR

2013-10-01

... http://www.dhs.gov. A convenient but unofficial up-to-date version of the HSAR is also available from the Government Printing office at http://www.gpoaccess.gov/ecfr/index.html. The Homeland Security Acquisition Manual (HSAM), which complements the HSAR, can also be found at http://www.dhs.gov. [77 FR 50632...

Canadian Ranger Rifle: Human Factors Requirements Validation

DTIC Science & Technology

2010-08-01

index-eng.asp retrieved 9 February 2010 2 http://www.armee.forces.gc.ca/land-terre/cr-rc/history- histoire -eng.asp retrieved 9 February 2010 3 http... histoire -eng.asp Department of National Defence. (2010). Canadian Ranger Patrol (CRPG). Retrieved June 3, 2010, from http://www.army.forces.gc.ca

48 CFR 1201.105-3 - Copies.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Office, Washington, DC 20402. The electronic version of the Federal Register may be found at http://www.nara.gov and the CFR at http://www.gpoaccess.gov. (b) The (TAR) 48 CFR chapter 12 and Transportation Acquisition Circulars (TACs) are available on the Internet at http://www.dot.gov/ost/m60. ...

40 CFR Appendix A to Subpart E of... - References

Code of Federal Regulations, 2012 CFR

2012-07-01

..., WI 53202 (http://qualitypress.asq.org). (2) American National Standard Quality Systems for... American Society for Quality, P.O. Box 3005, Milwaukee, WI 53202 (http://qualitypress.asq.org). (3) Quality... 1998 or later edition. Currently available at http://www.epa.gov/ttn/amtic/pmqainf.html. (4) Military...

9 CFR 121.12 - Biosafety.

Code of Federal Regulations, 2013 CFR

2013-01-01

... http://www.aphis.usda.gov/programs/ag_selectagent/index.html. (2) The Occupational Safety and Health... Involving Recombinant DNA Molecules.” This document is available on the Internet at http://www.aphis.usda...); adding a second sentence to paragraph (c)(2); in paragraph (c)(3), by removing the address “http://www...

48 CFR 1201.105-3 - Copies.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Office, Washington, DC 20402. The electronic version of the Federal Register may be found at http://www.nara.gov and the CFR at http://www.gpoaccess.gov. (b) The (TAR) 48 CFR chapter 12 and Transportation Acquisition Circulars (TACs) are available on the Internet at http://www.dot.gov/ost/m60. ...

48 CFR 1201.105-3 - Copies.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Office, Washington, DC 20402. The electronic version of the Federal Register may be found at http://www.nara.gov and the CFR at http://www.gpoaccess.gov. (b) The (TAR) 48 CFR chapter 12 and Transportation Acquisition Circulars (TACs) are available on the Internet at http://www.dot.gov/ost/m60. ...

48 CFR 1201.105-3 - Copies.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Office, Washington, DC 20402. The electronic version of the Federal Register may be found at http://www.nara.gov and the CFR at http://www.gpoaccess.gov. (b) The (TAR) 48 CFR chapter 12 and Transportation Acquisition Circulars (TACs) are available on the Internet at http://www.dot.gov/ost/m60. ...

12 CFR 7.1016 - Independent undertakings to pay against documents.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Publishing, Inc., 212/206-1150; http://www.iccwbo.org); the Supplements to UCP 500 & 600 for Electronic... Electronic Presentation) (available from ICC Publishing, Inc., 212/206-1150; http://www.iccwbo.org... Banking Law & Practice, 301/869-9840; http://www.iiblp.org); the United Nations Convention on Independent...

47 CFR 15.38 - Incorporation by reference.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., 25 West 43rd Street, 4th Floor, New York, NY 10036 or at http://webstore.ansi.org/ansidocstore/default.asp; or Society of Cable Telecommunications Engineers at http://www.scte.org/standards/index.cfm...: Consumer Electronics Association, 2500 Wilson Blvd., Arlington, VA 22201 or at http://www.ce.org...

Constraining the physical structure of the inner few 100 AU scales of deeply embedded low-mass protostars

NASA Astrophysics Data System (ADS)

Persson, M. V.; Harsono, D.; Tobin, J. J.; van Dishoeck, E. F.; Jørgensen, J. K.; Murillo, N.; Lai, S.-P.

2016-05-01

Context. The physical structure of deeply embedded low-mass protostars (Class 0) on scales of less than 300 AU is still poorly constrained. While molecular line observations demonstrate the presence of disks with Keplerian rotation toward a handful of sources, others show no hint of rotation. Determining the structure on small scales (a few 100 AU) is crucial for understanding the physical and chemical evolution from cores to disks. Aims: We determine the presence and characteristics of compact, disk-like structures in deeply embedded low-mass protostars. A related goal is investigating how the derived structure affects the determination of gas-phase molecular abundances on hot-core scales. Methods: Two models of the emission, a Gaussian disk intensity distribution and a parametrized power-law disk model, are fitted to subarcsecond resolution interferometric continuum observations of five Class 0 sources, including one source with a confirmed Keplerian disk. Prior to fitting the models to the de-projected real visibilities, the estimated envelope from an independent model and any companion sources are subtracted. For reference, a spherically symmetric single power-law envelope is fitted to the larger scale emission (~1000 AU) and investigated further for one of the sources on smaller scales. Results: The radii of the fitted disk-like structures range from ~90-170 AU, and the derived masses depend on the method. Using the Gaussian disk model results in masses of 54-556 × 10-3 M⊙, and using the power-law disk model gives 9-140 × 10-3 M⊙. While the disk radii agree with previous estimates the masses are different for some of the sources studied. Assuming a typical temperature distribution (r-0.5), the fractional amount of mass in the disk above 100 K varies from 7% to 30%. Conclusions: A thin disk model can approximate the emission and physical structure in the inner few 100 AU scales of the studied deeply embedded low-mass protostars and paves the way for analysis of a larger sample with ALMA. Kinematic data are needed to determine the presence of any Keplerian disk. Using previous observations of p-H218O, we estimate the relative gas phase water abundances relative to total warm H2 to be 6.2 × 10-5 (IRAS 2A), 0.33 × 10-5 (IRAS 4A-NW), 1.8 × 10-7 (IRAS 4B), and < 2 × 10-7 (IRAS 4A-SE), roughly an order of magnitude higher than previously inferred when both warm and cold H2 were used as reference. A spherically symmetric single power-law envelope model fails to simultaneously reproduce both the small- and large-scale emission. Based on observations carried out with the IRAM Plateau de Bure Interferometer. IRAM is supported by INSU/CNRS (France), MPG (Germany) and IGN (Spain).Continuum data for the sources are available through http://dx.doi.org/10.5281/zenodo.47642 and at CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/590/A33

PHYSICS EDUCATION AND THE INTERNET: A beginner's guide to a physicist starting out on an Internet journey

NASA Astrophysics Data System (ADS)

Burton, Paul

1998-05-01

Thirty useful physics-related sites are listed to help get you started. I hope you will find some of the following sites of use in your teaching or good for pointing your pupils in the right direction when doing research. I have not attempted to rank or sort them in any order. However, by the time you read this issue of Physics Education some of the sites may not be available; this is the nature of the net. Those not wishing to retype each address can access them from my school's physics page (http://www.bootham.demon.co.uk/physics/links.html) or e-mail me at pkb@bootham.demon.co.uk and I can send you a document with the hypertext live links in. The new IOP sponsored 16-19 Physics project is promising great things with its own Internet site. You will be able to download information, updates, worksheets etc. Any queries about the development of this project at present can be sent to Evelyn van Dyk at: 16-19project@iop.org Engineering and Physical Sciences Research Councilhttp://www.epsrc.ac.uk Particle Physics and Astronomy Research Councilhttp://www.pparc.ac.uk American Institute of Physicshttp://www.aip.org Usenet Physics FAQ (frequently asked questions)http://www.weburbia.demon.co.uk/physics/faq.html CERNhttp://www.cern.ch/ BBC Educationhttp://www.bbc.co.uk/education/ Useful data on the Periodic Tablehttp://www.shef.ac.uk/chemistry/web-elements/ JET WWW index page:http://www.jet.uk NERC satellite station, Dundee Universityhttp://www.sat.dundee.ac.uk/ The Meteorological Officehttp://www.meto.govt.uk/ The Smithsonian Institute, Washington, DChttp://www.si.edu/newstart.htm Frequently asked questions on time and frequencyhttp://www.boulder.nist.gov/timefreq/faq/faq.htm Physics newshttp://www.het.brown.edu/news/index.html TIPTOP: The Internet Pilot to Physicshttp://www.tp.umu.se/TIPTOP/ A Dictionary of Scientific Quotationshttp://naturalscience.com/dsqhome.html ScI-Journal: an on-line publication for science studentshttp://www.soton.ac.uk/~plf/ScI-Journal/ Science On-linehttp://www.shu.ac.uk/schools/sci/sol/contents.htm Physics humourhttp://quark.physics.uwo.ca/~harwood/humor12.htm Searching for someone's e-mail address?http://www.four11.com SKY publicationshttp://www.skypub.com Planet Sciencehttp://www.keysites.com New Scientisthttp://www.newscientist.com NASA links to the American space programhttp://www.nasa.gov NASA Jet Propulsion Laboratoryhttp://www.jpl.nasa.gov Hewlett-Packardhttp://www.hp.com The Bradford Schools Telescope Projecthttp://www.telescope.org/rti/nuffield/ To contact a professional societyhttp://www.lib.uwaterloo.ca/society/overview.html The Schools' Physics Group: post-16 issueshttp://diana.ecs.soton.ac.uk/~pm/Physics/post16.html Sleuth search for physics and chemistryhttp://www.isleuth.com/index.shtml The Particle Adventurehttp://pdg.lbl.gov/cpep/adventure_home.html Acknowledgments I thank colleagues David Robinson and Robin Peach for their help in selecting and validating these sites and William Try, pupil at Bootham School, for preparing and maintaining the department's homepage with hypertext links. Received 21 January 1998

Sea & Space: a New European Educational Programme

NASA Astrophysics Data System (ADS)

1998-01-01

This spring, teachers across Europe will enjoy support for exciting, novel educational projects on astronomy, navigation and environmental observations. The largely web-based and highly interactive SEA & SPACE programme makes it possible for pupils to perform field experiments and astronomical observations and to obtain and process satellite images. A contest will take the best pupils for one week to Lisbon (Portugal), to Europe's space port in Kourou (French Guyana) where the European launcher lifts off or to ESO's Very Large Telescope at the Cerro Paranal Observatory in Chile, the largest optical telescope in the world. The SEA & SPACE project is a joint initiative of the European Space Agency (ESA) , the European Southern Observatory (ESO) , and the European Association for Astronomy Education (EAAE). It builds on these organisations' several years' successful participation in the European Week for Scientific and Technological Culture organised by the European Commission that they intend to continue in 1998. The 1998 World Exhibition EXPO98 in Lisbon will focus on the oceans. This is why the umbrella theme of SEA & SPACE is concerned with the many relations between the oceans and the space that surrounds us, from ancient times to present days. Under the new programme, teaching resources are offered for three major areas, Remote Sensing of Europe's Coastal Environment, Navigation and Oceans of Water. Remote Sensing of Europe's Coastal Environment : observations of the Earth from Space are made accessible to pupils who will appreciate their usefulness through interactive image processing and field observations; Navigation : the capabilities and functioning of different navigation techniques are explored through experiments using navigation by the stars, with GPS, and via satellite images/maps; Oceans of Water : What is the role of water in Nature? How can one detect water from satellites or with telescopes? How much water is there in rivers and floods, in an ocean, on Mars, in comets, in stars, in the Universe? SEA & SPACE will use the Internet and the WWW to transport teaching resources so that teachers and pupils can communicate with the organisers and among themselves. To this end, the National Committees of the European Association for Astronomy Education will operate sites onto which the information and resources provided by ESA and ESO are loaded. The Contest, in which pupils will write and design a poster or a newspaper on a subject related to SEA & SPACE, will be organised simultaneously in most European countries and will not require Internet access. SEA & SPACE will start as from 1 March 1998. Further information is provided on the Home Pages of ESA, ESO and EAAE. In early February, a dedicated joint SEA & SPACE Home Page will be operational where schools can register for the project and for regular mailing of new information: * http://www.esa.int/seaspace * http://www.eso.org/seaspace * http://www.algonet.se/~sirius/eaae/seaspace Note: [1] This press release is published jointly by ESA, ESO and EAAE. How to obtain ESO Press Information ESO Press Information is made available on the World-Wide Web (URL: http://www.eso.org../). ESO Press Photos may be reproduced, if credit is given to the European Southern Observatory.

When Will It Be... USNO Seasons and Apsides Calculator

NASA Astrophysics Data System (ADS)

Chizek Frouard, Malynda; Bartlett, Jennifer Lynn

2018-01-01

The turning of the Earth’s seasons (solstices and equinoxes) and apsides (perihelions and aphelions) are times often used in observational astronomy and also of interest to the public. To avoid tedious calculations, the U.S. Naval Observatory (USNO) has developed an on-line interactive calculator, Earth’s Seasons and Apsides to provide information about events between 1600 and 2200. The new data service uses an Application Programming Interface (API), which returns values in JavaScript Object Notation (JSON) that can be incorporated into third-party websites or applications. For a requested year, the Earth’s Seasons and Apsides API provides the Gregorian calendar date and time of the Vernal Equinox, Summer Solstice, Autumnal Equinox, Winter Solstice, Aphelion, and Perihelion. The user may specify the time zone for their results, including the optional addition of U.S. daylight saving time for years after 1966.On-line documentation for using the API-enabled Earth’s Seasons and Apsides is available, including sample calls (http://aa.usno.navy.mil/data/docs/api.php). A traditional forms-based interface is available as well (http://aa.usno.navy.mil/data/docs/EarthSeasons.php). This data service replaces the popular Earth's Seasons: Equinoxes, Solstices, Perihelion, and Aphelion page that provided a static list of events for 2000–2025. The USNO also provides API-enabled data services for Complete Sun and Moon Data for One Day (http://aa.usno.navy.mil/data/docs/RS_OneDay.php), Dates of the Primary Phases of the Moon (http://aa.usno.navy.mil/data/docs/MoonPhase.php), Selected Christian Observances (http://aa.usno.navy.mil/data/docs/easter.php), Selected Islamic Observances (http://aa.usno.navy.mil/data/docs/islamic.php), Selected Jewish Observances (http://aa.usno.navy.mil/data/docs/passover.php), Julian Date Conversion (http://aa.usno.navy.mil/data/docs/JulianDate.php), and Sidereal Time (http://aa.usno.navy.mil/data/docs/siderealtime.php) as well as its Solar Eclipse Computer (http://aa.usno.navy.mil/data/docs/SolarEclipses.php).

MiCroKit 3.0: an integrated database of midbody, centrosome and kinetochore.

PubMed

Ren, Jian; Liu, Zexian; Gao, Xinjiao; Jin, Changjiang; Ye, Mingliang; Zou, Hanfa; Wen, Longping; Zhang, Zhaolei; Xue, Yu; Yao, Xuebiao

2010-01-01

During cell division/mitosis, a specific subset of proteins is spatially and temporally assembled into protein super complexes in three distinct regions, i.e. centrosome/spindle pole, kinetochore/centromere and midbody/cleavage furrow/phragmoplast/bud neck, and modulates cell division process faithfully. Although many experimental efforts have been carried out to investigate the characteristics of these proteins, no integrated database was available. Here, we present the MiCroKit database (http://microkit.biocuckoo.org) of proteins that localize in midbody, centrosome and/or kinetochore. We collected into the MiCroKit database experimentally verified microkit proteins from the scientific literature that have unambiguous supportive evidence for subcellular localization under fluorescent microscope. The current version of MiCroKit 3.0 provides detailed information for 1489 microkit proteins from seven model organisms, including Saccharomyces cerevisiae, Schizasaccharomyces pombe, Caenorhabditis elegans, Drosophila melanogaster, Xenopus laevis, Mus musculus and Homo sapiens. Moreover, the orthologous information was provided for these microkit proteins, and could be a useful resource for further experimental identification. The online service of MiCroKit database was implemented in PHP + MySQL + JavaScript, while the local packages were developed in JAVA 1.5 (J2SE 5.0).

Discovery of candidate KEN-box motifs using cell cycle keyword enrichment combined with native disorder prediction and motif conservation.

PubMed

Michael, Sushama; Travé, Gilles; Ramu, Chenna; Chica, Claudia; Gibson, Toby J

2008-02-15

KEN-box-mediated target selection is one of the mechanisms used in the proteasomal destruction of mitotic cell cycle proteins via the APC/C complex. While annotating the Eukaryotic Linear Motif resource (ELM, http://elm.eu.org/), we found that KEN motifs were significantly enriched in human protein entries with cell cycle keywords in the UniProt/Swiss-Prot database-implying that KEN-boxes might be more common than reported. Matches to short linear motifs in protein database searches are not, per se, significant. KEN-box enrichment with cell cycle Gene Ontology terms suggests that collectively these motifs are functional but does not prove that any given instance is so. Candidates were surveyed for native disorder prediction using GlobPlot and IUPred and for motif conservation in homologues. Among >25 strong new candidates, the most notable are human HIPK2, CHFR, CDC27, Dab2, Upf2, kinesin Eg5, DNA Topoisomerase 1 and yeast Cdc5 and Swi5. A similar number of weaker candidates were present. These proteins have yet to be tested for APC/C targeted destruction, providing potential new avenues of research.

On the Social Construction of Overdiagnosis Comment on "Medicalisation and Overdiagnosis: What Society Does to Medicine".

PubMed

Hofmann, Bjørn

2017-02-25

In an interesting article Wieteke van Dijk and colleagues argue that societal developments and values influence the practice of medicine, and thus can result in both medicalisation and overdiagnosis. They provide a convincing argument that overdiagnosis emerges in a social context and that it has socially constructed implications. However, they fail to show that overdiagnosis per se is socially constructed and how this construction occurs. Moreover, the authors discuss overdiagnosis on a micro level without acknowledging that overdiagnosis cannot be observed in individuals "in the doctor's office." We cannot tell whether a diagnosed person is overdiagnosed or not. This is the core of the problem. Despite these shortcomings, Wieteke van Dijk and her colleagues are certainly on to something important, and they should be encouraged to elaborate their perspective. We certainly need to deepen our understanding of the social construction of overdiagnosis. © 2017 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

MiCroKit 3.0: an integrated database of midbody, centrosome and kinetochore

PubMed Central

Liu, Zexian; Gao, Xinjiao; Jin, Changjiang; Ye, Mingliang; Zou, Hanfa; Wen, Longping; Zhang, Zhaolei; Xue, Yu; Yao, Xuebiao

2010-01-01

During cell division/mitosis, a specific subset of proteins is spatially and temporally assembled into protein super complexes in three distinct regions, i.e. centrosome/spindle pole, kinetochore/centromere and midbody/cleavage furrow/phragmoplast/bud neck, and modulates cell division process faithfully. Although many experimental efforts have been carried out to investigate the characteristics of these proteins, no integrated database was available. Here, we present the MiCroKit database (http://microkit.biocuckoo.org) of proteins that localize in midbody, centrosome and/or kinetochore. We collected into the MiCroKit database experimentally verified microkit proteins from the scientific literature that have unambiguous supportive evidence for subcellular localization under fluorescent microscope. The current version of MiCroKit 3.0 provides detailed information for 1489 microkit proteins from seven model organisms, including Saccharomyces cerevisiae, Schizasaccharomyces pombe, Caenorhabditis elegans, Drosophila melanogaster, Xenopus laevis, Mus musculus and Homo sapiens. Moreover, the orthologous information was provided for these microkit proteins, and could be a useful resource for further experimental identification. The online service of MiCroKit database was implemented in PHP + MySQL + JavaScript, while the local packages were developed in JAVA 1.5 (J2SE 5.0). PMID:19783819

Sustaining the Knowledge Base of the United States Air Force for Future Operations

DTIC Science & Technology

2015-12-10

Comptroller, 53, no. 1 (Winter 2008), 20. 30 “Lagan Web Self-Service: Knowledge Management,” 19 September 2015, http://www.kana.com/lagan- crm ...2015, http://www.kana.com/lagan- crm /knowledge-management. Madden, Leign. “U.S. Air Force Soaring to the Cloud with Office 365,” http

23 CFR 630.1110 - Maintenance of temporary traffic control devices.

Code of Federal Regulations, 2010 CFR

2010-04-01

... available for purchase from ATSSA through the following URL: http://www.atssa.com/store/bc_item_detail.jsp... http://dot.state.il.us/workzone/wztcd2004r.pdf. The Minnesota Department of Transportation “Quality... Unacceptable” is available online at http://www.dot.state.mn.us/trafficeng/otepubl/fieldmanual2007/FM-2007...

10 CFR 431.303 - Materials incorporated by reference.

Code of Federal Regulations, 2010 CFR

2010-01-01

... this material at NARA, call 202-741-6030 or go to http://www.archives.gov/federal_register/code_of... through Friday, except Federal holidays, or go to: http://www1.eere.energy.gov/buildings/appliance... and Materials, 100 Barr Harbor Drive, West Conshohocken, PA 19428-2959, (610) 832-9500, or http://www...

77 FR 33622 - Airworthiness Directives; Alpha Aviation Concept Limited (Type Certificate Previously Held by...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-07

[email protected]nz ; Internet: http://www.alphaaviation.co.nz . You may review copies of the referenced service... 8040; email: [email protected]nz ; Internet: http://www.alphaaviation.co.nz . You may... 64 7 843 7070; fax: 011 64 7843 8040; email: [email protected]nz ; Internet: http...

32 CFR 117.53 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

...,” (available at http://www.dtic.mil/whs/directives/corres/pdf/520507p.pdf). Classified contract. As defined in... Military and Associated Terms” (available at http://www.dtic.mil/doctrine/new_pubs/jp1_02.pdf). Company. As..., “Joint Communication System” (available at http://www.dtic.mil/doctrine/new_pubs/jp6_0.pdf). Contractor...

77 FR 69591 - President's Export Council: Meeting of the President's Export Council

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-20

... posted in advance of the meeting on the President's Export Council Web site at http://trade.gov/pec... broadcast via live webcast on the Internet at http://whitehouse.gov/live . FOR FURTHER INFORMATION CONTACT...: Electronic Submissions Submit statements electronically via the President's Export Council Web site at http...

32 CFR 239.15 - List of HAP field offices.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Address: http://www.spk.usace.army.mil Alaska, Arizona, California, Nevada, Utah, Idaho, Oregon, Pacific....O. Box 889, Savannah, GA 31402-0889. 1-800-861-8144. Internet Address: http://www.sas.usace.army.mil..., TX 76102-0300. (817) 886-1112. 1-888-231-7751. Internet Address: http://www.swf.usace.army.mil...

48 CFR 522.805 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OFCCP regional office. A list of these offices can be found at http://www.dol.gov/esa/contacts/ofccp/ofcpkeyp.htm. (c) The EEO poster required by FAR 22.805(b) can be found at: http://www.dol.gov/esa/regs... contracting officer shall advise contractors to complete the Employer Information Report (EEO-1) at http://www...

76 FR 31299 - Request for Applications for the Veterinary Medicine Loan Repayment Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-31

... release of the Veterinary Medicine Loan Repayment Program (VMLRP) Request for Applications (RFA) at http...) application package has been made available at http://www.nifa.usda.gov/vmlrp and applications are due by... Education. The NSLDS website can be found at http://www.nslds.ed.gov . Individuals who consolidated their...

75 FR 70956 - Post Office Closing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-19

... electronically via the Commission's Filing Online system at http:[sol][sol]www.prc.gov. Those who cannot submit... supporting material on its Web site at http:[sol][sol]www.prc.gov. Additional filings in this case and...) pursuant to Commission rules 9(a) and 10(a) at the Commission's Web site, http:[sol][sol]www.prc.gov...

75 FR 70965 - Petition for Exemption; Summary of Petition Received

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-19

... rulemaking Web site: Go to http:[sol][sol]www.regulations.gov and follow the instructions for sending your.... Privacy: We will post all comments we receive, without change, to http:[sol][sol]www.regulations.gov... 19477-78). Docket: To read background documents or comments received, go to http:[sol][sol]www...

48 CFR 570.106-1 - Synopsis of lease awards.

Code of Federal Regulations, 2014 CFR

2014-10-01

... officers must synopsize in http://www.FBO.gov awards exceeding $25,000 total contract value that are likely... means where access to the notice of proposed lease action was provided through http://www.FBO.gov; and... than full and open competition must be posted in http://www.FBO.gov. Information exempt from public...

14 CFR § 1260.75 - Summary of report requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... site (eNTRe) at: http://invention.nasa.gov. (6) An Election of Title to a Subject Invention is required... site (eNTRe) at: http://invention.nasa.gov. (8) A Notification of Decision to Forego Patent Protection... (eNTRe) at: http://invention.nasa.gov. (2) A Final Federal Cash Transactions Report, SF 272, is...

14 CFR 1260.75 - Summary of report requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

...NTRe) at: http://invention.nasa.gov. (6) An Election of Title to a Subject Invention is required for... site (eNTRe) at: http://invention.nasa.gov. (8) A Notification of Decision to Forego Patent Protection... (eNTRe) at: http://invention.nasa.gov. (2) A Final Federal Cash Transactions Report, SF 272, is...

14 CFR 1260.75 - Summary of report requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

...NTRe) at: http://invention.nasa.gov. (6) An Election of Title to a Subject Invention is required for... site (eNTRe) at: http://invention.nasa.gov. (8) A Notification of Decision to Forego Patent Protection... (eNTRe) at: http://invention.nasa.gov. (2) A Final Federal Cash Transactions Report, SF 272, is...

14 CFR 1260.75 - Summary of report requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

...NTRe) at: http://invention.nasa.gov. (6) An Election of Title to a Subject Invention is required for... site (eNTRe) at: http://invention.nasa.gov. (8) A Notification of Decision to Forego Patent Protection... (eNTRe) at: http://invention.nasa.gov. (2) A Final Federal Cash Transactions Report, SF 272, is...

14 CFR 1260.75 - Summary of report requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

...NTRe) at: http://invention.nasa.gov. (6) An Election of Title to a Subject Invention is required for... site (eNTRe) at: http://invention.nasa.gov. (8) A Notification of Decision to Forego Patent Protection... (eNTRe) at: http://invention.nasa.gov. (2) A Final Federal Cash Transactions Report, SF 272, is...

48 CFR 570.106-1 - Synopsis of lease awards.

Code of Federal Regulations, 2013 CFR

2013-10-01

... officers must synopsize in http://www.FBO.gov awards exceeding $25,000 total contract value that are likely... means where access to the notice of proposed lease action was provided through http://www.FBO.gov; and... than full and open competition must be posted in http://www.FBO.gov. Information exempt from public...

48 CFR 570.106-1 - Synopsis of lease awards.

Code of Federal Regulations, 2012 CFR

2012-10-01

... officers must synopsize in http://www.FBO.gov awards exceeding $25,000 total contract value that are likely... means where access to the notice of proposed lease action was provided through http://www.FBO.gov; and... than full and open competition must be posted in http://www.FBO.gov. Information exempt from public...

48 CFR 570.106-1 - Synopsis of lease awards.

Code of Federal Regulations, 2011 CFR

2011-10-01

... officers must synopsize in http://www.FBO.gov awards exceeding $25,000 total contract value that are likely... means where access to the notice of proposed lease action was provided through http://www.FBO.gov; and... than full and open competition must be posted in http://www.FBO.gov. Information exempt from public...

40 CFR Appendix A to Subpart A of... - References

Code of Federal Regulations, 2014 CFR

2014-07-01

...-1994. Available from American Society for Quality, P.O. Box 3005, Milwaukee, WI 53202 (http... P.O. Box 3005, Milwaukee, WI 53202 (http://qualitypress.asq.org). (3) Dimensioning and Tolerancing... available at http://www.epa.gov/ttn/amtic/pmqainf.html. [62 FR 38784, July 18, 1997, as amended at 71 FR...

40 CFR Appendix A to Subpart A of... - References

Code of Federal Regulations, 2012 CFR

2012-07-01

...-1994. Available from American Society for Quality, P.O. Box 3005, Milwaukee, WI 53202 (http... P.O. Box 3005, Milwaukee, WI 53202 (http://qualitypress.asq.org). (3) Dimensioning and Tolerancing... available at http://www.epa.gov/ttn/amtic/pmqainf.html. [62 FR 38784, July 18, 1997, as amended at 71 FR...

40 CFR Appendix A to Subpart A of... - References

Code of Federal Regulations, 2013 CFR

2013-07-01

...-1994. Available from American Society for Quality, P.O. Box 3005, Milwaukee, WI 53202 (http... P.O. Box 3005, Milwaukee, WI 53202 (http://qualitypress.asq.org). (3) Dimensioning and Tolerancing... available at http://www.epa.gov/ttn/amtic/pmqainf.html. [62 FR 38784, July 18, 1997, as amended at 71 FR...

End-to-End Service Oriented Architectures (SOA) Security Project

DTIC Science & Technology

2012-02-01

ActivClientforCommonAccessCards/ [CAC3] http://koji.fedoraproject.org/ koji /packageinfo?packageID=5 [CAC4] https://help.ubuntu.com/community...Ubuntu10.4-LTS-32.html [CAC8] http://dodpki.c3pki.chamb.disa.mil/rootca.html [CAC9] http://koji.fedoraproject.org/ koji /packageinfo?packageID=5 [CAC10

Yahoo! Alternatives.

ERIC Educational Resources Information Center

Pack, Thomas

1999-01-01

Presents overviews of three relatively new sites that have much in common with the directory "Yahoo!"-Snap (http://www.snap.com), LookSmart (http://www.looksmart.com), and eBLAST (http://www.eBLAST.com). Describes findings of sample searches to help users compare and contrast the type of results that can be expected from each directory.…

77 FR 75195 - Notice of a Virtual Meeting of the Advisory Committee on Apprenticeship (ACA)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-19

... Office of Apprenticeship's (OA) homepage: http://www.doleta.gov/oa/ . The ACA is a discretionary... will be prominently posted on the OA homepage: http://www.doleta.gov/oa/ . Members of the public are... OA's homepage: http://www.doleta.gov/oa/ . All meeting participants, whether attending virtually or...

NEW METABOLITES FROM THE MICROBIAL OXIDATION OF FLUORINATED AROMATIC COMPOUNDS. (R826113)

EPA Science Inventory

Abstract

m-Bromo-,,45 CFR 170.299 - Incorporation by reference.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., MI 48104; Telephone (734) 677-7777 or http://www.hl7.org/. (1) Health Level Seven Standard Version 2..., PA, 19428-2959 USA; Telephone (610) 832-9585 or http://www.astm.org/. (1) ASTM E2369-05: Standard...) 477-1000; and Facsimile (480) 767-1042 or http://www.ncpdp.org. (1) National Council for Prescription...

24 CFR 100.201a - Incorporation by reference.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., DC 20001-2070, telephone number 1-888-422-7233, http://www.iccsafe.org/e/category.html. (2) American..., DC 20001-2070, telephone number 1-888-422-7233, http://www.iccsafe.org/e/category.html. (3) American..., DC 20001-2070, telephone number 1-888-422-7233, http://www.iccsafe.org/e/category.html. (4) American...

Visualizing and communicating uncertainty in the earth and environmental sciences: a review

NASA Astrophysics Data System (ADS)

Pebesma, Edzer

2014-05-01

I will review past attempts to visualising uncertainty in spatial or spatio-temporal predictions of groundwater quality, quality predictions, sea bed sediment, bird densities, air quality measurements, and exposure to air quality of individuals and populations. The attempts involved software development (aguila [1], greenland [2]), the development of standards for communicating uncertain spatial and spatio-temporal information (UncertML, [3]), and have been illustrated by applications in a number of EU projects (Apmosphere [4], INTAMAP [5], UncertWeb [6] and GeoViQua [7]). I will also report on usability studies that were carried out (e.g. [8]). [1] http://pcraster.geo.uu.nl/projects/developments/aguila/ [2] https://wiki.52north.org/bin/view/Geostatistics/Greenland [3] http://www.uncertml.org/ [4] http://www.apmosphere.org/ [5] http://www.intamap.org/ [6] http://www.uncertweb.org/ [7] http://www.geoviqua.org/ [8] Senaratne, H. L. Gerharz, E. Pebesma, A. Schwering, 2012. Usability of Spatio-Temporal Uncertainty Visualisation Methods. In: Bridging the Geographic Information Sciences, Lecture Notes in Geoinformation and Cartography, J. Gensel, D. Josselin and D. Vandenbroucke. Springer Berlin Heidelberg.

Ensembl BioMarts: a hub for data retrieval across taxonomic space.

PubMed

Kinsella, Rhoda J; Kähäri, Andreas; Haider, Syed; Zamora, Jorge; Proctor, Glenn; Spudich, Giulietta; Almeida-King, Jeff; Staines, Daniel; Derwent, Paul; Kerhornou, Arnaud; Kersey, Paul; Flicek, Paul

2011-01-01

For a number of years the BioMart data warehousing system has proven to be a valuable resource for scientists seeking a fast and versatile means of accessing the growing volume of genomic data provided by the Ensembl project. The launch of the Ensembl Genomes project in 2009 complemented the Ensembl project by utilizing the same visualization, interactive and programming tools to provide users with a means for accessing genome data from a further five domains: protists, bacteria, metazoa, plants and fungi. The Ensembl and Ensembl Genomes BioMarts provide a point of access to the high-quality gene annotation, variation data, functional and regulatory annotation and evolutionary relationships from genomes spanning the taxonomic space. This article aims to give a comprehensive overview of the Ensembl and Ensembl Genomes BioMarts as well as some useful examples and a description of current data content and future objectives. Database URLs: http://www.ensembl.org/biomart/martview/; http://metazoa.ensembl.org/biomart/martview/; http://plants.ensembl.org/biomart/martview/; http://protists.ensembl.org/biomart/martview/; http://fungi.ensembl.org/biomart/martview/; http://bacteria.ensembl.org/biomart/martview/.

Delay Differential Equation-Based Modeling of Passively Mode-Locked Quantum Dot Lasers Using Measured Gain and Loss Spectra (Postprint)

DTIC Science & Technology

2013-01-01

semiconductor laser8, 9: ATAe d dA TQiTGi qg 12 11 2 1 (1) 2 0 1 AeeGgd dG GQ (2) Proc. of SPIE Vol. 8255 82551K-2 Downloaded From: http...1 Downloaded From: http://spiedigitallibrary.org/ on 01/14/2013 Terms of Use: http://spiedl.org/terms 1 Approved for public release; distribution...parameters ( 0g and 0q , respectively) have been derived to yield: Gg0 (10) Proc. of SPIE Vol. 8255 82551K-3 Downloaded From: http

Diagnosis and prediction of neuroendocrine liver metastases: a protocol of six systematic reviews.

PubMed

Arigoni, Stephan; Ignjatovic, Stefan; Sager, Patrizia; Betschart, Jonas; Buerge, Tobias; Wachtl, Josephine; Tschuor, Christoph; Limani, Perparim; Puhan, Milo A; Lesurtel, Mickael; Raptis, Dimitri A; Breitenstein, Stefan

2013-12-23

Patients with hepatic metastases from neuroendocrine tumors (NETs) benefit from an early diagnosis, which is crucial for the optimal therapy and management. Diagnostic procedures include morphological and functional imaging, identification of biomarkers, and biopsy. The aim of six systematic reviews discussed in this study is to assess the predictive value of Ki67 index and other biomarkers, to compare the diagnostic accuracy of morphological and functional imaging, and to define the role of biopsy in the diagnosis and prediction of neuroendocrine tumor liver metastases. An objective group of librarians will provide an electronic search strategy to examine the following databases: MEDLINE, EMBASE and The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials (CENTRAL), Database of Abstracts of Reviews of Effects). There will be no restriction concerning language and publication date. The qualitative and quantitative synthesis of the systematic review will be conducted with randomized controlled trials (RCT), prospective and retrospective comparative cohort studies, and case-control studies. Case series will be collected in a separate database and only used for descriptive purposes. This study is ongoing and presents a protocol of six systematic reviews to elucidate the role of histopathological and biochemical markers, biopsies of the primary tumor and the metastases as well as morphological and functional imaging modalities for the diagnosis and prediction of neuroendocrine liver metastases. These systematic reviews will assess the value and accuracy of several diagnostic modalities in patients with NET liver metastases, and will provide a basis for the development of clinical practice guidelines. The systematic reviews have been prospectively registered with the International Prospective Register of Systematic Reviews (PROSPERO): CRD42012002644; http://www.metaxis.com/prospero/full_doc.asp?RecordID=2644 (Archived by WebCite at http://www.webcitation.org/6LzCLd5sF), CRD42012002647; http://www.metaxis.com/prospero/full_doc.asp?RecordID=2647 (Archived by WebCite at http://www.webcitation.org/6LzCRnZnO), CRD42012002648; http://www.metaxis.com/prospero/full_doc.asp?RecordID=2648 (Archived by WebCite at http://www.webcitation.org/6LzCVeuVR), CRD42012002649; http://www.metaxis.com/prospero/full_doc.asp?RecordID=2649 (Archived by WebCite at http://www.webcitation.org/6LzCZzZWU), CRD42012002650; http://www.metaxis.com/prospero/full_doc.asp?RecordID=2650 (Archived by WebCite at http://www.webcitation.org/6LzDPhGb8), CRD42012002651; http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42012002651#.UrMglPRDuVo (Archived by WebCite at http://www.webcitation.org/6LzClCNff).

One-pot synthesis of hollow NiSe-CoSe nanoparticles with improved performance for hybrid supercapacitors

NASA Astrophysics Data System (ADS)

Chen, Haichao; Fan, Meiqiang; Li, Chao; Tian, Guanglei; Lv, Chunju; Chen, Da; Shu, Kangying; Jiang, Jianjun

2016-10-01

Hollow NiSe-CoSe samples have been synthesized for the first time via a one-pot solvothermal approach. The strategy is robust enough to synthesize NiSe-CoSe nanoparticles with different NiSe to CoSe ratios but with a similar hollow structure. Co ions in the NiSe-CoSe nanoparticles play decisive role for formation of the hollow structure; otherwise, the nanoparticles become solid for the NiSe sample. When used as the positive electroactive materials for energy storage, the NiSe-CoSe samples show excellent electrochemical activity in alkaline electrolyte. Using the synergistic effect between NiSe and CoSe, the electrochemical performance of NiSe-CoSe can be tuned by varying the NiSe to CoSe ratios. The NiSe-CoSe sample with a NiSe to CoSe ratio of 4:2 shows the best electrochemical performance in terms of superior specific capacity, improved rate capability and excellent cycling stability. In addition, the electrochemical performance of NiSe-CoSe sample with a NiSe to CoSe ratio of 4:2 is also evaluated via assembling hybrid supercapacitors with RGO, and the hybrid supercapacitor delivers both high power and energy densities (41.8 Wh kg-1 at 750 W kg-1 and 20.3 Wh kg-1 at 30 kW kg-1).

47 CFR 73.8000 - Incorporation by reference.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Engineering and Technology (OET) Web site: http://www.fcc.gov/oet/info/documents/bulletins/. (1) OET Bulletin...., Suite 1200, Washington, DC 20006, or at the ATSC Web site: http://www.atsc.org/standards.html. (1) ATSC... Standards Institute (ANSI), 25 West 43rd Street, 4th Floor, New York, NY 10036 or at the ANSI Web site: http...

76 FR 7629 - Open Meeting of the President's Council on Jobs and Competitiveness (PCJC)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-10

... open to the public via live webcast at http://www.whitehouse.gov/live . DATES: The meeting will be held... posted on the White House website ( http://www.whitehouse.gov ) without change, including any business or... the internet via live webcast at http://www.whitehouse.gov/live . The purpose of this meeting is to...

Global Jihad: The Role of Europe’s Radical Muslims

DTIC Science & Technology

2007-12-01

Abdelhak Najib and Karim Serraj, “Said Chedadi and Sheik Najib, the Missing Link of May 16?” La Gazette Du Maroc , 29 October 2003, http...Chedadi and Sheik Najib, the Missing Link of May 16?” La Gazette Du Maroc , 29 October 2003. http://translate.google.com/translate?u=http%3 A%2F%2

77 FR 47287 - Bacillus thuringiensis eCry3.1Ab Protein in Corn; Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-08

..., is available either electronically through http://www.regulations.gov or in hard copy at the OPP... instructions and additional information about the docket available at http://www.epa.gov/dockets . FOR FURTHER... methods: Federal eRulemaking Portal: http://www.regulations.gov . Follow the online instructions for...

49 CFR 22.57 - Loan reporting requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... indicates the date in which the loan has been activated/funded. The form is available at http://www.osdbu... repayment of the STLP loan, or upon expiration of the loan guarantee. The form is available at http://www... Report and form DOT F 2305-1 Guaranty Loan Status Report. These forms are available at http://www.osdbu...

77 FR 2098 - Advisory Committee on the Medical Uses of Isotopes: Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-13

... Subcommittee Report. A copy of the agenda for the meeting will be available at http://www.nrc.gov/reading-rm/doc-collections/acmui/agenda . Handouts for the meeting will be available at http://www.nrc.gov... will be available on the ACMUI's web site ( http://www.nrc.gov/reading-rm/doc-collections/acmui/tr...

75 FR 40864 - Notice of Fiscal Year 2010 Border Grant Funding and Solicitation for Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-14

... Federal Grant Web site, http://www.grants.gov . Eligible projects for funding with BEG are identified in... applications for BEG funding at the Federal Grant Web site, http://www.grants.gov . FOR FURTHER INFORMATION... the MOE explanation, http://www.fmcsa.dot.gov/safety-security/grants/beg/moe.aspx . The Border...

75 FR 22736 - Notice of Request for Applications for the Veterinary Medicine Loan Repayment Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-30

... (RFA) at http://www.nifa.usda.gov/vmlrp . DATES: The FY 2010 Veterinary Medicine Loan Repayment Program (VMLRP) application package has been made available at http://www.nifa.usda.gov/vmlrp and applications... http://www.nslds.ed.gov . Individuals who consolidated their DVM loans with non-educational loans or...

75 FR 67392 - Notice of Availability: HUD's Fiscal Year (FY) NOFA for the Choice Neighborhoods Initiative-Round...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-02

..., HUD. ACTION: Notice extension of deadline. SUMMARY: On August 26, 2010, HUD posted on http://www...--Round 1. Today's Federal Register notice announces that HUD has posted on http://www.Grants.gov a... to the Mapping Tool used to determine neighborhood eligibility. HUD will post on http://www.Grants...

78 FR 54476 - Availability of Draft National Toxicology Program Technical Reports; Request for Comments; Notice...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-04

... glycidamide. The draft TRs should be available by September 20, 2013, at http://ntp.niehs.nih.gov/go/36051... attendance and comment. Information about the meeting and registration are available at http://ntp.niehs.nih... Time (EDT). Document Availability: Draft TRs should be available by September 20, 2013, at http://ntp...

76 FR 578 - Notice of Funding Availability (NOFA) for Fiscal Year 2010; Rural Innovation Fund Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-05

.... SUMMARY: On December 22, 2010, HUD posted on http://www.Grants.gov its Notice of Funding Availability... publication announces that HUD has posted on http://www.Grants.gov a technical correction that, most... Fund grant.'' The revised NOFA can be found and downloaded from http://www.Grants.gov , using the CFDA...

78 FR 57457 - Notice of Funds Availability Inviting Applications for Grants for Transportation of Veterans in...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-18

..., VA announced that a copy of the Application Package can be downloaded directly from `` http://www.ruralhealth.va.gov/coordination-pilot/index.asp ''. It should have read, `` http://www.grants.gov/web/grants... CONTACT heading, remove `` http://www.ruralhealth.va.gov/coordination-pilot/index.asp '' and add, in its...

75 FR 40856 - Federal Register Meeting Notice; Webinar About Regional Innovation Clusters RFP

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-14

... potential Offerors about the Regional Innovation Clusters RFP. For more information please go to http://www.sba.gov/clusters/index.html . The RFP may be found on http://www.fedbizopps.gov . Logistical Information: The webinar will be held on Thursday, July 15, 2010. For details, please visit http://www.sba.gov...

76 FR 61478 - Open Meeting of the President's Council on Jobs and Competitiveness (PCJC)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-04

.... Eastern Time. The meeting will be open to the public via live Webcast at http://www.whitehouse.gov/live... Web site ( http://www.whitehouse.gov ) without change, including any business or personal information... meeting will be broadcast on the internet via live Webcast at http://www.whitehouse.gov/live . The purpose...

75 FR 59322 - Notice of Availability of Answers to Frequently Asked Questions Regarding Buy America & FRA's...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-27

... Asked Questions can be found on FRA's Web site at http://www.fra.dot.gov/Pages/11.shtml . DATES: Written... electronic site at http://www.regulations.gov . Commenters should follow the instructions below for mailed and hand-delivered comments. (1) Web Site: http://www.regulations.gov . Follow the instructions for...

14 CFR 11.63 - How and to whom do I submit my petition for rulemaking or petition for exemption?

Code of Federal Regulations, 2010 CFR

2010-01-01

..., submit your petition for rulemaking or exemption to FAA through the Internet at http://www.regulations.gov, the Federal Docket Management System Web site. For additional instructions, you may visit http... 20590 or by electronic submission to this Internet address: http://www.regulations.gov. (c) The FAA may...

49 CFR 365.105 - Starting the application process: Form OP-1.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Offices and Service Centers can be found at: http://www.fmcsa.dot.gov/aboutus/fieldoffices. The forms and information about filing procedures can be downloaded at: http://www.fmcsa.dot.gov/factsfigs/formspubs; and from the do-it-yourself website at: http://www.diy.dot.gov. [66 FR 49870, Oct. 1, 2001, as amended at...

78 FR 16857 - Office of the Assistant Secretary for Financial Resources, Office of Grants and Acquisition...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-19

... Inventory.'' The following should be changed: The notice provided an incorrect URL address: http://www.hhs.gov/grants/servicecontractsfy11.html . The correct URL address is as follows: http://www.hhs.gov... following URL address: http://www.hhs.gov/grants/servicecontractsfy11.html . Change the fiscal year to FY...

76 FR 16629 - Federal Travel Regulation (FTR); Relocation Allowances-Relocation Income Tax Allowance (RITA) Tables

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-24

... other FTR Bulletins can be found at http://www.gsa.gov/ftrbulletin . The RIT allowance tables are located at http://www.gsa.gov/relocationpolicy . DATES: This notice is effective March 24, 2011. FOR... CFR part 301-17 Appendices A through D. The tables will be published at http://www.gsa.gov...

77 FR 32621 - Developing Large-Scale Renewable Energy Projects at Federal Facilities Using Private Capital Draft

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-01

... consider comments and recommendations on the draft guidebook, which is available at: http://www1.eere... draft guidebook is available at: http://www1.eere.energy.gov/femp/pdfs/largereguide.pdf . DOE will... DATES section. More information on DOE's FEMP is available at: http://www1.eere.energy.gov/femp...

76 FR 31680 - Open Meeting of the President's Council on Jobs and Competitiveness (PCJC)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-01

... p.m. Eastern Time. The meeting will be open to the public via live webcast at http://www.whitehouse... Web site ( http://www.whitehouse.gov ) without change, including any business or personal information.... The meeting will be broadcast on the internet via live webcast at http://www.whitehouse.gov/live . The...

76 FR 70412 - Smart Grid Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-14

... recommendations that the Committee will consider at the meeting will be posted on the SGAC Web site at http://www... posted on the Smart Grid Web site at http://www.nist.gov/smartgrid . DATES: The SGAC will hold a meeting... (5 U.S.C. App.). Background information on the Committee is available at http://www.nist.gov...

75 FR 57107 - Open Meeting of the President's Economic Recovery Advisory Board (the PERAB)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-17

... live webcast at http://www.whitehouse.gov/live . DATES: The meeting will be held on October 4, 2010 at... Web site ( http://www.whitehouse.gov ) without change, including any business or personal information... via live webcast at http://www.whitehouse.gov/live . The purpose of this meeting is to continue...

The Battle for Hill 3234: Last Ditch Defense in the Mountains of Afghanistan

DTIC Science & Technology

2011-01-01

tridtsati devyati’ [The Oath of the 39], Krasnay zvezda [Red star], 29 October 1988; Schofield, 121; and time line from http://www.rsva.ru/ biblio /prose_af...Time line from http://www.rsva.ru/ biblio /prose_af/afghan-soldiers/4.shtml (accessed 20 September 2010). 29 Time line from http://www.rsva.ru/ biblio

Net Zero Water Update

DTIC Science & Technology

2011-05-12

www.epa.gov/nrmrl/pubs/600r09048/600r09048.pdf • http://www.epa.gov/awi/res_rehabilitation.html Net Zero Waste • http://www.army.mil/-news/2011/02...24/52403-net- zero - waste -goal-becoming-a-reality- at-jblm/ • http://www.operationfree.net/2011/04/11/u-s-army-looks-to-net- zero - waste / 27

ACHP | New and Improved Course: The Section 106 Essentials

Science.gov Websites

Interior's Standards for the Treatment of Historic Properties: 36 CFR Part 68 http://www.nps.gov/history Park Service History and Culture Publications http://www.nps.gov/history/index.htm National Park ://www.nps.gov/history/nagpra/ Technical Preservation Services for Historic Buildings http://www.nps.gov/tps

78 FR 38027 - Wilkesboro Hydroelectric Company, LLC; Wilkesboro Hydropower, LLC; Notice of Application for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-25

... viewed or printed on the eLibrary link of Commission's Web site at http://www.ferc.gov/docs-filing... Commission's Web site under http://www.ferc.gov/docs-filing/efiling.asp . Commenters can submit brief comments up to 6,000 characters, without prior registration, using the eComment system at http://www.ferc...

77 FR 22328 - Guidance for Industry on the Judicious Use of Medically Important Antimicrobial Drugs in Food...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-13

... electronic comments on the guidance to http:[sol][sol]www.regulations.gov. Submit written comments to the... at either http:[sol][sol]www.fda.gov/AnimalVeterinary/ GuidanceComplianceEnforcement/GuidanceforIndustry/default.htm or http:[sol][sol]www.regulations.gov. Dated: April 5, 2012. David Dorsey, Acting...

76 FR 38340 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-30

...: http:[sol][sol]www.regulations.gov. Follow the on-line instructions. 2. E-mail: [email protected] docket without change and may be made available online at http:[sol][sol]www.regulations.gov, including... otherwise protected should be clearly identified as such and should not be submitted through http:[sol][sol...

75 FR 73996 - Approval and Promulgation of State Air Quality Plans for Designated Facilities and Pollutants...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-30

...:[sol][sol]www.regulations.gov, including any personal information provided, unless the comment includes... http:[sol][sol]www.regulations.gov or e-mail. The http:[sol][sol]www.regulations.gov Web site is an... through http:[sol][sol]www.regulations.gov, your e-mail address will be automatically captured and...

77 FR 35703 - Collection of Information Under Review by Office of Management and Budget

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-14

... the docket on the Internet at http:[sol][sol] www.regulations.gov . A copy of the ICR is available through the docket on the Internet at http:[sol][sol] www.regulations.gov . Additionally, copies are... be received by July 16, 2012. We will post all comments received, without change, to http:[sol][sol...

75 FR 32533 - WTO Dispute Settlement Proceeding Regarding United States-Anti-Dumping Measures on Certain Shrimp...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... should be submitted electronically to http:[sol][sol] www.regulations.gov , docket number USTR-2010-0008. If you are unable to submit comments using http:[sol][sol] www.regulations.gov , please contact Sandy.... Persons may submit public comments electronically to http:[sol][sol] www.regulations.gov docket number...

50 CFR 622.14 - Area closures related to the Deepwater Horizon oil spill.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Web site: http://sero.nmfs.noaa.gov/deepwater_horizon_oil_spill.htm. (b) Gulf EEZ area closure related... the Gulf EEZ identified in the map shown on the NMFS Web site: http://sero.nmfs.noaa.gov/deepwater... shown on the NMFS Web site: http://sero.nmfs.noaa.gov/deepwater_horizon_oil_spill.htm. ...

47 CFR 0.441 - General.

Code of Federal Regulations, 2014 CFR

2014-10-01

... information and general inquiries may be submitted by: (1) Internet at http://www.fcc.gov/cgb/fccinfo or http://www.fcc.gov/foia. (2) Telephone at 1-888-CALL-FCC (1-888-225-5322). (3) TDD/TDY at 1-888-TELL-FCC (1... in resolving any concerns related to a Freedom of Information Act request. See http://www.fcc.gov...

47 CFR 0.441 - General.

Code of Federal Regulations, 2013 CFR

2013-10-01

... information and general inquiries may be submitted by: (1) Internet at http://www.fcc.gov/cgb/fccinfo or http://www.fcc.gov/foia. (2) Telephone at 1-888-CALL-FCC (1-888-225-5322). (3) TDD/TDY at 1-888-TELL-FCC (1... in resolving any concerns related to a Freedom of Information Act request. See http://www.fcc.gov...

47 CFR 0.441 - General.

Code of Federal Regulations, 2011 CFR

2011-10-01

... information and general inquiries may be submitted by: (1) Internet at http://www.fcc.gov/cgb/fccinfo or http://www.fcc.gov/foia. (2) Telephone at 1-888-CALL-FCC (1-888-225-5322). (3) TDD/TDY at 1-888-TELL-FCC (1... in resolving any concerns related to a Freedom of Information Act request. See http://www.fcc.gov...

76 FR 49401 - Universal Service-Intercarrier Compensation Transformation

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-10

... comments. Federal Communications Commission's Web Site: http://fjallfoss.fcc.gov/ecfs2/ . Follow the... available on the Commission's Web site at http://www.fcc.gov . Pursuant to Sec. Sec. 1.415 and 1.419 of the... 12th Street, SW., Room CY-B402, Washington, DC 20554; Web site: http://www.bcpiweb.com ; phone: 1-800...

36 CFR 1206.72 - Where can I find the regulatory requirements that apply to NHPRC grants?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Organizations.” This circular is available at http://www.whitehouse.gov/omb/circulars_default. (b) The OMB Circulars are available at http://www.whitehouse.gov/omb/circulars/index.html. (c) Additional policy... proficiency, is provided in Commission guidance at http://www.archives.gov/nhprc/ and from the NHPRC staff...

49 CFR 22.57 - Loan reporting requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... indicates the date in which the loan has been activated/funded. The form is available at http://www.osdbu... repayment of the STLP loan, or upon expiration of the loan guarantee. The form is available at http://www... Report and form DOT F 2305-1 Guaranty Loan Status Report. These forms are available at http://www.osdbu...

36 CFR 1206.72 - Where can I find the regulatory requirements that apply to NHPRC grants?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Organizations.” This circular is available at http://www.whitehouse.gov/omb/circulars_default. (b) The OMB Circulars are available at http://www.whitehouse.gov/omb/circulars/index.html. (c) Additional policy... proficiency, is provided in Commission guidance at http://www.archives.gov/nhprc/ and from the NHPRC staff...

32 CFR 239.15 - List of HAP field offices.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., Sacramento, CA 95814-2922, (916) 557-6850 OR, 1-800-811-5532, Internet Address: http://www.spk.usace.army.mil..., 1-800-861-8144, Internet Address: http://www.sas.usace.army.mil Alabama, Georgia, North Carolina..., CESWF, P.O. Box 17300, Fort Worth, TX 76102-0300, (817) 886-1112, 1-888-231-7751, Internet Address: http...

49 CFR 7.27 - What are the designated DOT FOIA Requester Service Centers?

Code of Federal Regulations, 2014 CFR

2014-10-01

... numbers identified at http://www.dot.gov/foia or the mailing addresses indicated below (unless a more up-to-date mailing address has been designated at http://www.dot.gov/foia): (1) FOIA Requester Service... Highway Administration, Room E64-302 (unless a more specific address has been designated by FHWA at http...

32 CFR 239.15 - List of HAP field offices.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., Sacramento, CA 95814-2922, (916) 557-6850 OR, 1-800-811-5532, Internet Address: http://www.spk.usace.army.mil..., 1-800-861-8144, Internet Address: http://www.sas.usace.army.mil Alabama, Georgia, North Carolina..., CESWF, P.O. Box 17300, Fort Worth, TX 76102-0300, (817) 886-1112, 1-888-231-7751, Internet Address: http...

36 CFR § 1206.72 - Where can I find the regulatory requirements that apply to NHPRC grants?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Organizations.” This circular is available at http://www.whitehouse.gov/omb/circulars_default. (b) The OMB Circulars are available at http://www.whitehouse.gov/omb/circulars/index.html. (c) Additional policy... proficiency, is provided in Commission guidance at http://www.archives.gov/nhprc/ and from the NHPRC staff...

49 CFR 365.105 - Starting the application process: Form OP-1.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Offices and Service Centers can be found at: http://www.fmcsa.dot.gov/aboutus/fieldoffices. The forms and information about filing procedures can be downloaded at: http://www.fmcsa.dot.gov/factsfigs/formspubs; and from the do-it-yourself website at: http://www.diy.dot.gov. [66 FR 49870, Oct. 1, 2001, as amended at...

49 CFR 365.105 - Starting the application process: Form OP-1.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Offices and Service Centers can be found at: http://www.fmcsa.dot.gov/aboutus/fieldoffices. The forms and information about filing procedures can be downloaded at: http://www.fmcsa.dot.gov/factsfigs/formspubs; and from the do-it-yourself website at: http://www.diy.dot.gov. [66 FR 49870, Oct. 1, 2001, as amended at...

32 CFR 161.4 - Policy.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Instruction 1000.1, “Identity Cards Required by the Geneva Convention” (available at http://www.dtic.mil/whs...” (available at http://www.dtic.mil/whs/directives/corres/pdf/100025p.pdf). (d) The CAC, a form of DoD ID card... Contractors” (available at http://www.dhs.gov/xabout/laws/gc_1217616624097.shtm). (e) ID cards, in a form...

Internet over a Bi-Directional Satellite Link

NASA Technical Reports Server (NTRS)

Griner, Jim; Allman, Mark; Mallasch, Paul; Stewart, David

1998-01-01

Various issues associated with "Internet over a Bi-Directional Satellite Link" are presented in viewgraph form. Specific topics include: 1) Comarison of HTTP over several network channels; 2) Improved performance of HTTP when compared to off-the-shelf software; 3) Demonstration setup of the link between Sheraton Airport Hotel, Dulles and NASA LeRC; and 4) HTTP comparison pages.

77 FR 62264 - Notice of a Virtual Meeting of the Advisory Committee on Apprenticeship (ACA)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-12

... from the Office of Apprenticeship's (OA) homepage: http://www.doleta.gov/oa/ . The ACA is a... instructions to participate in this meeting will be prominently posted on the OA homepage: http://www.doleta... meeting. All meeting updates will be posted to OA's homepage: http://www.doleta.gov/oa/ . All meeting...

75 FR 6688 - Section 8 Housing Assistance Payments Program-Renewal Funding Annual Adjustment Factors, Fiscal...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-10

... were published in a separate notice which can be viewed at: http://www.huduser.org/portal/datasets/aaf... be available electronically from the HUD data information page at http://www.huduser.org/portal... overview and in the FMR documentation at http://www.HUDUSER.org . In this publication, the rent and utility...

49 CFR 575.3 - Matter incorporated by reference.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., Switzerland, +41 22 749 01 11, http://www.iso.org/iso/home.htm. All ISO materials are also available from the..., New York, NY 10036-7417, 212-642-4900, http://www.ansi.org/. (1) International Organization for... Barr Harbor Drive, PO Box C700, West Conshohocken, PA 19428-2959, 610-832-9500, http://www.astm.org...

76 FR 77533 - Mandatory Electronic Filing for Cable Special Relief Petitions and Cable Show Cause Petitions...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-13

... FEDERAL COMMUNICATIONS COMMISSION [DA 11-1930] Mandatory Electronic Filing for Cable Special... Web site http://www.BCPIWEB.com using document number DA 11-1930 for the CSR and CSC Electronic Filing... Commission's Web site: http://hraunfoss.fcc.gov/edocs_public/attachmatch/DA-11-1930A1.doc ; http://hraunfoss...

Especially for High School Teachers

NASA Astrophysics Data System (ADS)

Howell, J. Emory

2001-05-01

Literature Cited

1. National Science Education Standards; National Academy Press: Washington, DC, 1996; http://www. nap.edu/readingroom/books/nses/.
2. Principles and Standards for School Mathematics; National Council of Teachers of Mathematics: Washington, DC, 2000; http://standards.nctm.org/.

Selenium fractions in organic matter from Se-rich soils and weathered stone coal in selenosis areas of China.

PubMed

Qin, Hai-bo; Zhu, Jian-ming; Su, Hui

2012-02-01

A high degree of association between Selenium (Se) and organic matter has been demonstrated in natural environments, but Se fractions and speciation in organic matter is unclear. In this study, a method for quantifying organic matter associated with Se (OM-Se) was developed to investigate Se fractions in organic matter in Se-rich soils and weathered stone coal from Enshi, China, where Se poisoning of humans and livestock has been documented. Initially, Se was extracted using water and a phosphate buffer. Subsequently, OM-Se was extracted using NaOH, and then speciated into Se associated with fulvic acids (FA-Se) and humic acids (HA-Se). Both FA-Se and HA-Se were further speciated into the weakly bound and strongly bound fractions using a customized hydride generation reactor. The results show that FA-Se (1.91-479 mg kg(-1)) is the predominant form of Se in all Se-rich soils and the weathered stone coal samples, accounting for more than 62% of OM-Se (3.07-484 mg kg(-1)). Weakly bound FA-Se (1.33-450 mg kg(-1)) was prevalent in the total FA-Se, while weakly bound HA-Se (0.62-26.2 mg kg(-1)) was variable in the total HA-Se (1.15-32.5 mg kg(-1)). These data indicate that OM-Se could play a significant source and sink role in the biogeochemical cycling of Se in the supergene environment. Weakly bound FA-Se seems to act as a potential source for bioavailable Se, whereas strongly bound HA-Se is a possible OM-Se sink which is not readily transformed into bioavailable Se. Copyright © 2011 Elsevier Ltd. All rights reserved.

75 FR 10241 - Town of Dexter; Notice of Declaration of Intention and Soliciting Comments, Protests, and/or...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-05

..., ME 04930; telephone: (207) 924-0180; e-mail: http: //[email protected]net . i. FERC Contact... site at http://www.ferc.gov .filing- comments.asp. Please include the docket number (DI10-7-000) on any... document. You may also register online at http://www.ferc.gov/docs-filing/esubscription.asp to be notified...

Exploiting Weaknesses: An Approach to Counter Cartel Strategy

DTIC Science & Technology

2011-12-01

AnimalPolitco, September 24, 2011, http://www.animalpolitico.com/2011/09/tranquilidad- en -frontera-de-tamaulipas-por- construccion -de-base-militar...activities. 140 “Informacion de Ubicaciones Casas de Seguridad , Halcones, Etc. Nuevo Laredo en Vivo,” Mapa nuevolaredoenvivo.es.tl, http...148 “Informacion de Ubicaciones Casas de Seguridad , Halcones, Etc. Nuevo Laredo en Vivo,” Mapa nuevolaredoenvivo.es.tl, http

75 FR 16575 - Open Meeting of the President's Economic Recovery Advisory Board (the PERAB)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-01

... meeting will be open to the public via live Webcast at http://www.whitehouse.gov/live . DATES: The meeting... will be posted on the White House Web site ( http://www.whitehouse.gov ) without change, including any...:30 p.m. Eastern Time. The meeting will be broadcast on the Internet via live Webcast at http://www...

76 FR 54195 - 2010 Resources Planning Act (RPA) Assessment Draft

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-31

... Resources Planning Act (RPA) Assessment is available for review and comment at http://www.fs.fed.us/research... facsimile to 703-605-5131 or by email using the comment form on the Web site http://www.fs.fed.us/research... . Additional information about the RPA Assessment can be obtained on the Internet at http://www.fs.fed.us...

The COROT Archive at LAEFF

NASA Astrophysics Data System (ADS)

Velasco, Almudena; Gutiérrez, Raúl; Solano, Enrique; García-Torres, Miguel; López, Mauro; Sarro, Luis Manuel

We describe here the main capabilities of the COROT archive. The archive (http://sdc.laeff.inta.es/corotfa/jsp/searchform.jsp), managed at LAEFF in the framework of the Spanish Virtual Observatory (http://svo.laeff.inta.es), has been developed following the standards and requirements defined by IVOA (http://www.ivoa.net). The COROT archive at LAEFF will be publicly available by the end of 2008.

When Green Goes Bad: A Computational Ecology Approach to a Better Understanding of Cyanobacteria, Nutrients, and Lakes 

EPA Science Inventory

The presentation is part of a larger, similar body of work. Related works include http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=282620, http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=279534, and http://cfpub.epa.gov/si/si_public_record_report.cfm...

76 FR 71037 - Proposed National Toxicology Program (NTP) Review Process for the Report on Carcinogens: Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-16

... the list of speakers, will be posted on the NTP Web site ( http://ntp.niehs.nih.gov/go/rocprocess... ( http://ntp.niehs.nih.gov/go/rocprocess ). The guidelines and deadlines published in the Federal... 27560. Registration for the listening session is via the NTP Web site ( http://ntp.niehs.nih.gov/go...

40 CFR 350.16 - Address to send trade secrecy claims and petitions requesting disclosure.

Code of Federal Regulations, 2010 CFR

2010-07-01

... chemical identities claimed as trade secret are posted on the following EPA Program Web sites, http://www.epa.gov/ceppo and http://www.epa.gov/tri. Any subsequent changes to the address and location will be...) 424-9346 or (703) 412-9810, TDD (800) 553-7672, http://www.epa.gov/epaoswer/hotline/ to obtain this...

36 CFR 1233.16 - How does an agency transfer records to the National Personnel Records Center (NPRC)?

Code of Federal Regulations, 2010 CFR

2010-07-01

...-1800, Web site http://www.opm.gov/feddata/recguide2008.pdf, for the OPM publication “The Guide to... Records Center (NPRC), St. Louis, MO” section of the NARA Federal Records Centers Program Web site (http... assistance consult the NPRC Web site (http://www.archives.gov/facilities/mo/st7_louis.html). ...

76 FR 14017 - Call for Comments on the Draft Report of the Adult Immunization Working Group to the National...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-15

... and recommendations could be found on the Web at http://www.hhs.gov/nvpo/nvac/subgroups/adultimmunization . The Web address where the draft report and recommendations can be found is http://www.hhs.gov...) The draft report and recommendations are available on the Web at http://www.hhs.gov/nvpo/nvac...

75 FR 30105 - Solicitation of Applications for Fiscal Year (FY) 2010 Motor Carrier Safety Assistance Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-28

... on the grants.gov Web site ( http://www.grants.gov ). DATES: FMCSA will initially consider funding... register, go to http://www.grants.gov/applicants/get_registered.jsp . The applicant must download the grant... package. This can be done on the Internet at http://www.grants.gov/applicants/apply_for_grants.jsp . The...

32 CFR 806b.53 - Training tools.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Justice Privacy web pages. Go to http://www.foia.af.mil. Click on “Resources.” (b) “The Privacy Act of... Privacy Act 101 and is available on-line at http://www.foia.af.mil. (d) Training slides for use by the... http://www.foia.af.mil, under “Resources.” Note: Formal school training groups that develop or modify...

76 FR 54533 - Pipeline Safety: Issuance of Draft Decision on GexCon US, Inc. Petition for Approval of Flame...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-01

... inspection at Docket No. PHMSA-2011-0101 at http://www.regulations.gov . DATES: Submit comments by September... following ways: E-Gov Website: http://www.regulations.gov . This Web site allows the public to enter... comments received will be posted without change to http://www.regulations.gov , including any personal...

77 FR 1127 - Open Meeting of the President's Council on Jobs and Competitiveness (PCJC)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-09

... live webcast at http:[sol][sol]www.whitehouse.gov/live. DATES: The meeting will be held on January 17..., DC 20220. In general, all statements will be posted on the White House Web site (http:[sol][sol]www... 2 p.m. Eastern Time. The meeting will be broadcast on the internet via live webcast at http:[sol...

75 FR 52357 - Request for Comment: National Center for Complementary and Alternative Medicine Draft Strategic Plan

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-25

... through the NCCAM Web site at http://nccam.nih.gov from on or about August 30 through September 30, 2010... professionals, have been guided by NCCAM's previous strategic plans, located on the NCCAM Web site at http... provide comments from August 30 through September 30, 2010. The papers may be viewed at http://nccam.nih...

76 FR 800 - Policy and Procedural Change Regarding the Publication of Notices of Funding Opportunities in the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-06

... Web site, http://www.grants.gov , in accordance with the policy directive issued by the Office of... posted at http://www.grants.gov by following the universal resource locator (URL) link included in the synopsis, or by visiting ETA's Web site at http://www.doleta.gov . DATES: Effective Date: January 6, 2011...

2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

Code of Federal Regulations, 2010 CFR

2010-01-01

... registrations in the Central Contractor Registration (http://www.ccr.gov) at all times during which they have... System (DUNS) Number (http://www.dnb.com) is one of the requirements for registration in the Central... Recovery Act using the reporting instructions and data elements that will be provided online at http://www...

75 FR 31937 - Standards of Performance for New Stationary Sources and Emission Guidelines for Existing Sources...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-04

...-and-r[email protected] , Attention Docket ID No. EPA-HQ-OAR-2003-0119. Facsimile: Fax your comments to... otherwise protected through http://www.regulations.gov or e-mail. The http://www.regulations.gov Web site is... following Web site: http://www.epa.gov/airquality/combustion . Please refer to this Web site to confirm the...

75 FR 32005 - National Emission Standards for Hazardous Air Pollutants for Major Sources: Industrial...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-04

... Web site. E-mail: Comments may be sent by electronic mail (e-mail) to a-and-r[email protected] otherwise protected through http://www.regulations.gov or e-mail. The http://www.regulations.gov Web site is... Web site: http://www.epa.gov/airquality/combustion . Please refer to this Web site to confirm the date...

78 FR 14528 - Mayo Hydropower, LLC, Avalon Hydropower, LLC; Notice of Application for Transfer of License, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-06

... this project can be viewed or printed on the eLibrary link of Commission's Web site at http://www.ferc...) and the instructions on the Commission's Web site under http://www.ferc.gov/docs-filing/efiling.asp... system at http://www.ferc.gov/docs-filing/ecomment.asp . You must include your name and contact...

78 FR 78349 - Andrew Peklo III; Notice of Availability of Draft Environmental Assessment

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-26

... draft EA may also be viewed on the Commission's Web site at http://www.ferc.gov using the ``eLibrary... CFR 385.2001(a)(1)(iii) and the instructions on the Commission's Web site http://www.ferc.gov/docs... registration, using the eComment system at http://www.ferc.gov/docs-filing/ecomment.asp . You must include your...

78 FR 60271 - Hollow Dam Power Company; Ampersand Hollow Dam Hydro, LLC; Notice of Application for Transfer of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-01

...Library link of Commission's Web site at http://www.ferc.gov/docs-filing/elibrary.asp . Enter the docket...) and the instructions on the Commission's Web site under http://www.ferc.gov/docs-filing/efiling.asp... system at http://www.ferc.gov/docs-filing/ecomment.asp . You must include your name and contact...

76 FR 10580 - Cascade Creek, LLC; Notice of Draft License Application and Preliminary Draft Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-25

... the Internet. See 18 CFR 385.2001(a)(1)(iii) and the instructions on the Commission's Web site http..., without prior registration, using the eComment system at http://www.ferc.gov/docs-filing/ecomment.asp... at the Commission in the Public Reference Room or may be viewed on the Commission's Web site at http...

Representation

DTIC Science & Technology

2006-09-01

two weeks to arrive. Source: http://beergame.mit.edu/ Permission Granted – MIT Supply Chain Forum 2005 Professor Sterman –Sloan School of...Management - MITSource: http://web.mit.edu/jsterman/www/ SDG /beergame.html Rules of Engagement The MIT Beer Game Simulation 04-04 Slide Number 10 Professor...Sterman –Sloan School of Management - MITSource: http://web.mit.edu/jsterman/www/ SDG /beergame.html What is the Significance of Representation

77 FR 34032 - American River Power III, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-08

... Commission's Web site http:[sol][sol]www.ferc.gov/docs-filing/efiling.asp. Commenters can submit brief comments up to 6,000 characters, without prior registration, using the eComment system at http:[sol][sol... on the ``eLibrary'' link of Commission's Web site at http:[sol][sol]www.ferc.gov/docs-filing...

76 FR 12958 - Amnor Hydro West Inc.; Notice of Preliminary Permit Application Accepted for Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-09

... http:[sol][sol]www.ferc.gov/docs-filing/efiling.asp. Commenters can submit brief comments up to 6,000 characters, without prior registration, using the eComment system at http:[sol][sol]www.ferc.gov/docs-filing...Library'' link of Commission's Web site at http:[sol][sol]www.ferc.gov/docs-filing/ elibrary.asp. Enter...

75 FR 70923 - Office of the National Coordinator for Health Information Technology; HIT Standards Committee...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-19

... be conducted virtually only. Dial into the meeting: 1-877-705-6006; webcast: http:[sol][sol]altarum..., and the background material will be posted on ONC's Web site after the meeting, at http:[sol][sol... committed to the orderly conduct of its advisory committee meetings. Please visit our Web site at http:[sol...

78 FR 22275 - Collection of Information under Review by Office of Management and Budget

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-15

... following means: (1) Online: (a) To Coast Guard docket at http:[sol][sol] www.regulations.gov . (b) To OIRA... Federal holidays. You may also find the docket on the Internet at http:[sol][sol] www.regulations.gov . Copies of the ICRs are available through the docket on the Internet at http:[sol][sol] www.regulations...

32 CFR 806b.53 - Training tools.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Justice Privacy web pages. Go to http://www.foia.af.mil. Click on “Resources.” (b) “The Privacy Act of... Privacy Act 101 and is available on-line at http://www.foia.af.mil. (d) Training slides for use by the... http://www.foia.af.mil, under “Resources.” Note: Formal school training groups that develop or modify...

36 CFR § 1233.16 - How does an agency transfer records to the National Personnel Records Center (NPRC)?

Code of Federal Regulations, 2013 CFR

2013-07-01

...-1800, Web site http://www.opm.gov/feddata/recguide2008.pdf, for the OPM publication “The Guide to... Records Center (NPRC), St. Louis, MO” section of the NARA Federal Records Centers Program Web site (http... assistance consult the NPRC Web site (http://www.archives.gov/facilities/mo/st_louis.html). ...

32 CFR 806b.53 - Training tools.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Justice Privacy web pages. Go to http://www.foia.af.mil. Click on “Resources.” (b) “The Privacy Act of... Privacy Act 101 and is available on-line at http://www.foia.af.mil. (d) Training slides for use by the... http://www.foia.af.mil, under “Resources.” Note: Formal school training groups that develop or modify...

36 CFR 1233.16 - How does an agency transfer records to the National Personnel Records Center (NPRC)?

Code of Federal Regulations, 2014 CFR

2014-07-01

...-1800, Web site http://www.opm.gov/feddata/recguide2008.pdf, for the OPM publication “The Guide to... Records Center (NPRC), St. Louis, MO” section of the NARA Federal Records Centers Program Web site (http... assistance consult the NPRC Web site (http://www.archives.gov/facilities/mo/st_louis.html). ...

32 CFR 806b.53 - Training tools.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Justice Privacy web pages. Go to http://www.foia.af.mil. Click on “Resources.” (b) “The Privacy Act of... Privacy Act 101 and is available on-line at http://www.foia.af.mil. (d) Training slides for use by the... http://www.foia.af.mil, under “Resources.” Note: Formal school training groups that develop or modify...

NOMADS-NOAA Operational Model Archive and Distribution System

Science.gov Websites

Forecast Maps Climate Climate Prediction Climate Archives Weather Safety Storm Ready NOAA Central Library (16km) 6 hours grib filter http OpenDAP-alt URMA hourly - http - Climate Models Climate Forecast System Flux Products 6 hours grib filter http - Climate Forecast System 3D Pressure Products 6 hours grib

Individual, family, and group therapy for adolescents.

PubMed

McCann, Christina M; le Roux, Pieter

2006-02-01

The three main psychotherapeutic treatment modalities include individual,family, and group therapies. Many theoretic orientations guide psychotherapists as they try to help adolescents with mental health problems. PCPs play a critical role in initial assessment of mental health symptoms, in addition to coordinating treatment needs. There is a need for increased education regarding mental health treatment for health care providers to help them connect adolescents and their families to appropriate mental health care providers. Integrative approaches that involve more than one treatment modality are often needed to provide the best treatment for adolescents. Better collaborative care not only improves physician understanding of mental health treatment but also improves the mental health provider's understanding of the medical system [30]. This emerging con-text of increased mutual collaborative care builds a better system that serves the adolescent.Web-based resources related to psychotherapy for adolescents American Academy of Child and Adolescent Psychiatry http://www.AACAP.org American Association for Marriage & Family Therapy http://www.AAMFT.org American Psychological Association http://www.APA.org American Psychiatric Association http://www.psych.org National Mental Health Association http://www.NMHA.org National Alliance for the Mentally Ill http://www.NAMI.org

Rumen Microorganisms Decrease Bioavailability of Inorganic Selenium Supplements.

PubMed

Galbraith, M L; Vorachek, W R; Estill, C T; Whanger, P D; Bobe, G; Davis, T Z; Hall, J A

2016-06-01

Despite the availability of selenium (Se)-enriched trace mineral supplements, we have observed low Se status in cattle and sheep offered traditional inorganic Se supplements. Reasons for this may include inadequate intake or low bioavailability of inorganic Se sources. The objective of this study was to determine whether rumen microorganisms (RMO) alter the bioavailability of Se sources commonly used in Se supplements. Rumen microorganisms were isolated from ewes (n = 4) and incubated ex vivo with no Se (control), with inorganic Na selenite or Na selenate, or with organic selenomethionine (SeMet). Total Se incorporated into RMO and the amount of elemental Se formed were determined under equivalent conditions. Incorporation of Se from Na selenite, Na selenate, or SeMet into RMO was measured as fold change compared with control (no added Se). Incorporation of Se into microbial mass was greater for SeMet (13.2-fold greater than no-Se control) compared with inorganic Se supplements (P = 0.02); no differences were observed between inorganic Na selenate (3.3-fold greater than no-Se control) and Na selenite (3.5-fold greater than no-Se control; P = 0.97). Formation of non-bioavailable, elemental Se was less for RMO incubated with SeMet compared with inorganic Se sources (P = 0.01); no differences were observed between Na selenate and Na selenite (P = 0.09). The clinical importance of these results is that the oral bioavailability of organic SeMet should be greater compared with inorganic Se sources because of greater RMO incorporation of Se and decreased formation of elemental Se by RMO.

Pedagogies in Action: A Community Resource Linking Teaching Methods to Examples of their Use

NASA Astrophysics Data System (ADS)

Manduca, C. A.; Fox, S. P.; Iverson, E. A.; Kirk, K.; Ormand, C. J.

2009-12-01

The Pedagogies in Action portal (http://serc.carleton.edu/sp) provides access to information on more than 40 teaching methods with examples of their use in geoscience and beyond. Each method is described with pages addressing what the method is, why or when it is useful, and how it can be implemented. New methods added this year include Teaching with Google Earth, Jigsaw, Teaching the Process of Science, Guided Discovery Problems, Teaching Urban Students, and Using ConceptTests. Examples then show specifically how the method has been used to teach concepts in a variety of disciplines. The example collection now includes 775 teaching activities of which more than 550 are drawn from the geosciences. Geoscience faculty are invited to add their own examples to this collection or to test examples in the collection and provide a review. Evaluation results show that the combination of modules and activities inspires teachers at all levels to use a new pedagogy and increases their confidence that they can use it successfully. In addition, submitting activities to the collection, including writing summary information for other instructors, helps them think more carefully about the design of their activity. The activity collections are used both for ready to use activities and to find ideas for new activities. The portal provides overarching access to materials developed by a wide variety of collaborating partners each of which uses the service to create a customized pedagogic portal addressing a more specific audience. Of interest to AGU members are pedagogic portals on Starting Point: Teaching Introductory Geoscience (http://serc.carleton.edu/introgeo); On the Cutting Edge (http://serc.carleton.edu/NAGTWorkshops); Enduring Resources for Earth System Education (http://earthref.org/ERESE) Microbial Life Educational Resources (http://serc.carleton.edu/microbe_life); the National Numeracy Network (http://serc.carleton.edu/nnn/index.html); CAUSE: The Consortium for Undergraduate Statistics Education (http://causeweb.org); ComPADRE: Digital Resources for Physics and Astronomy Education (http://www.compadre.org) and Project Kaleidoscope (http://pkal.org). Pedagogies in Action is part of the National Science Digital Library (http://nsdl.org). Projects or groups interested in exploring use of the service can find information about using the service on the project website or contact the authors.

Nitrite Interference with Soluble COD Measurements from Aerobically Treated Wastewater.

PubMed

Ferraz, Fernanda M; Yuan, Qiuyan

2017-06-01

  This study aimed to determine the interference of nitrite () with soluble chemical oxygen demand (COD) measurements from the effluent of landfill leachate treated by sequencing batch reactors (SBRs). Synthetic wastewater assimilating young and old landfill leachate was used as influent for SBR1 and SBR2, respectively. A mixture of raw wastewater and landfill leachate was used as influent for SBR3. Due to the high ammonia concentration in the influent, different levels of partial nitrification were observed in all the reactors and was detected in the effluents. Theoretically, when is present in the effluent, 1 mg/L of accounts for 1.1 mg/L of COD (i.e., 1.1 mg COD/mg ) due to the oxidation of to . It was found that the value of 1.1 mg COD/mg was 3 times higher than the values obtained in the experiments with SBR1 and SBR3. In addition, the values obtained in the experiments with SBR2 were much higher than 1.1 mg COD/mg . These results suggest that the theoretical value of 1.1 mg COD/mg cannot be applied to predict the COD values caused by nitrite in the tested wastewaters. To obtain an accurate measurement of soluble COD in samples that contain nitrite, nitrite should be eliminated before the measurements.

Liquidus Projections of Bi-Se-Ga and Bi-Se-Te Ternary Systems

NASA Astrophysics Data System (ADS)

Lin, Po-han; Chen, Sinn-wen; Hwang, Jenn-dong; Chu, Hsu-shen

2016-12-01

This study determines the liquidus projections of both Bi-Se-Ga and Bi-Se-Te ternary systems which are constituent ternary systems of promising Bi-Se-Te-Ga thermoelectric materials. Ternary Bi-Se-Ga and Bi-Se-Te alloys are prepared. Their primary solidification phases are experimentally determined, and thermal analysis experiments are carried out. The liquidus projections are determined based on the ternary experimental results and phase diagrams of constituent binary systems. The Bi-Se-Ga system includes seven primary solidification phases, Bi, Ga, GaSe, Ga2Se3, Se, Bi2Se3, and (Bi2)n(Bi2Se3)m. In the Bi-Se-Te system, there are five primary solidification phases, Bi, (Bi2)n(Bi2Te3)m, Bi2(Se,Te)3, (Se,Te), and (Bi2)n(Bi2Se3)m. Both the (Bi2)n(Bi2Te3)m and (Bi2)n(Bi2Se3)m phases are not a single phase, but a collection of series undetermined phases. Large miscibility gaps are observed in the Bi-Se-Ga system. The temperatures of the invariant reactions, Liquid + Bi + GaSe = Ga and Liquid + Ga2Se3 = Bi + GaSe, are at 495 K (222 °C) and 533 K (260 °C), respectively.

Dismantling Multicomponent Behavioral Treatment for Insomnia in Older Adults: A Randomized Controlled Trial

PubMed Central

Epstein, Dana R.; Sidani, Souraya; Bootzin, Richard R.; Belyea, Michael J.

2012-01-01

Study Objective: Recently, the use of multicomponent insomnia treatment has increased. This study compares the effect of single component and multicomponent behavioral treatments for insomnia in older adults after intervention and at 3 months and 1 yr posttreatment. Design: A randomized, controlled study. Setting: Veterans Affairs medical center. Participants: 179 older adults (mean age, 68.9 yr ± 8.0; 115 women [64.2%]) with chronic primary insomnia. Interventions: Participants were randomly assigned to 6 wk of stimulus control therapy (SCT), sleep restriction therapy (SRT), the 2 therapies combined into a multicomponent intervention (MCI), or a wait-list control group. Measurements and Results: Primary outcomes were subjective (daily sleep diary) and objective (actigraphy) measures of sleep-onset latency (SOL), wake after sleep onset (WASO), total sleep time (TST), time in bed (TIB), and sleep efficiency (SE). Secondary outcomes were clinical measures including response and remission rates. There were no differences between the single and multicomponent interventions on primary sleep outcomes measured by diary and actigraphy. All treatments produced significant improvement in diary-reported sleep in comparison with the control group. Effect sizes for sleep diary outcomes were medium to large. Treatment gains were maintained at follow-up for diary and actigraph measured SOL, WASO, and SE. The MCI group had the largest proportion of treatment remitters. Conclusions: For older adults with chronic primary insomnia, the findings provide initial evidence that SCT, SRT, and MCI are equally efficacious and produce sustainable treatment gains on diary, actigraphy, and clinical outcomes. From a clinical perspective, MCI may be a preferred treatment due to its higher remission rate. Clinical Trial Information: Behavioral Intervention for Insomnia in Older Adults. NCT01154023. URL: http://clinicaltrials.gov/ct2/show/NCT01154023?term=Behavioral+Intervention+for+Insomnia+in+Older+Adults&rank=1. Citation: Epstein DR; Sidani S; Bootzin RR; Belyea MJ. Dismantling multicomponent behavioral treatment for insomnia in older adults: a randomized controlled trial. SLEEP 2012;35(6):797-805. PMID:22654199

Technical and scale efficiency in the delivery of child health services in Zambia: results from data envelopment analysis.

PubMed

Achoki, Tom; Hovels, Anke; Masiye, Felix; Lesego, Abaleng; Leufkens, Hubert; Kinfu, Yohannes

2017-01-05

Despite tremendous efforts to scale up key maternal and child health interventions in Zambia, progress has not been uniform across the country. This raises fundamental health system performance questions that require further investigation. Our study investigates technical and scale efficiency (SE) in the delivery of maternal and child health services in the country. The study focused on all 72 health districts of Zambia. We compiled a district-level database comprising health outcomes (measured by the probability of survival to 5 years of age), health outputs (measured by coverage of key health interventions) and a set of health system inputs, namely, financial resources and human resources for health, for the year 2010. We used data envelopment analysis to assess the performance of subnational units across Zambia with respect to technical and SE, controlling for environmental factors that are beyond the control of health system decision makers. Nationally, average technical efficiency with respect to improving child survival was 61.5% (95% CI 58.2% to 64.8%), which suggests that there is a huge inefficiency in resource use in the country and the potential to expand services without injecting additional resources into the system. Districts that were more urbanised and had a higher proportion of educated women were more technically efficient. Improved cooking methods and donor funding had no significant effect on efficiency. With the pressing need to accelerate progress in population health, decision makers must seek efficient ways to deliver services to achieve universal health coverage. Understanding the factors that drive performance and seeking ways to enhance efficiency offer a practical pathway through which low-income countries could improve population health without necessarily seeking additional resources. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Cycloplegic autorefraction versus subjective refraction: the Tehran Eye Study.

PubMed

Hashemi, Hassan; Khabazkhoob, Mehdi; Asharlous, Amir; Soroush, Sara; Yekta, AbbasAli; Dadbin, Nooshin; Fotouhi, Akbar

2016-08-01

To compare cycloplegic autorefraction with non-cycloplegic subjective refraction across all age and refractive error groups. In a cross-sectional study with random stratified cluster sampling, 160 clusters were chosen from various districts proportionate to the population of each district in Tehran. Following retinoscopy and autorefraction with the 0.25 D bracketing (Topcon KR-8000, Topcon, Tokyo, Japan), all participants had a subjective refraction. Then all participants underwent cycloplegic autorefraction. The final analysis was performed on 3482 participants with a mean age of 31.7 years (range 5-92 years). Based on cycloplegic and subjective refraction, mean spherical equivalent (SE) was +0.31±1.80 and -0.32±1.61 D, respectively (p<0.001). The 95% limits of agreement (LoA) between these two types of refraction were from -0.40 to 1.70 D. The largest difference between these two types of refraction was seen in the age group of 5-10 years (1.11±0.60 D), and the smallest difference was in the age group of >70 years (0.34±0.45 D). The 95% LoA was -0.52 to 0.89 D in patients with myopia and -0.12 to 2.04 D in patients with hyperopia. We found that female gender (coefficients=0.048), older age (coefficients=-0.247), higher education (coefficients=-0.043) and cycloplegic SE (coefficients=-0.472) significantly correlated with lower intermethod differences. The cycloplegic refraction is more sensitive than the subjective one to measure refractive error at all age groups especially in children and young adults. The cyclorefraction technique is highly recommended to exactly measure the refractive error in momentous conditions such as refractive surgery, epidemiological researches and amblyopia therapy, especially in hypermetropic eyes and paediatric cases. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Efficiency and productivity measurement of rural township hospitals in China: a bootstrapping data envelopment analysis.

PubMed

Cheng, Zhaohui; Cai, Miao; Tao, Hongbing; He, Zhifei; Lin, Xiaojun; Lin, Haifeng; Zuo, Yuling

2016-11-11

Township hospitals (THs) are important components of the three-tier rural healthcare system of China. However, the efficiency and productivity of THs have been questioned since the healthcare reform was implemented in 2009. The objective of this study is to analyse the efficiency and productivity changes in THs before and after the reform process. A total of 48 sample THs were selected from the Xiaogan Prefecture in Hubei Province from 2008 to 2014. First, bootstrapping data envelopment analysis (DEA) was performed to estimate the technical efficiency (TE), pure technical efficiency (PTE) and scale efficiency (SE) of the sample THs during the period. Second, the bootstrapping Malmquist productivity index was used to calculate the productivity changes over time. The average TE, PTE and SE of the sample THs over the 7-year period were 0.5147, 0.6373 and 0.7080, respectively. The average TE and PTE increased from 2008 to 2012 but declined considerably after 2012. In general, the sample THs experienced a negative shift in productivity from 2008 to 2014. The negative change was 2.14%, which was attributed to a 23.89% decrease in technological changes (TC). The sample THs experienced a positive productivity shift from 2008 to 2012 but experienced deterioration from 2012 to 2014. There was considerable space for TE improvement in the sample THs since the average TE was relatively low. From 2008 to 2014, the sample THs experienced a decrease in productivity, and the adverse alteration in TC should be emphasised. In the context of healthcare reform, the factors that influence TE and productivity of THs are complex. Results suggest that numerous quantitative and qualitative studies are necessary to explore the reasons for the changes in TE and productivity. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Socioeconomic gradients in body mass index (BMI) in US immigrants during the transition to adulthood: examining the roles of parental education and intergenerational educational mobility.

PubMed

Albrecht, Sandra S; Gordon-Larsen, Penny

2014-09-01

Despite comparatively lower socioeconomic status (SES), immigrants tend to have lower body weight and weaker SES gradients relative to US-born individuals. Yet, it is unknown how changes in SES over the life-course relate to body weight in immigrants versus US-born individuals. We used longitudinal data from a nationally representative, diverse sample of 13 701 adolescents followed into adulthood to investigate whether associations between SES mobility categories (educational attainment reported by individuals as adults and by their parents during adolescence) and body mass index (BMI) measured in adulthood varied by immigrant generation. Weighted multivariable linear regression models were adjusted for age, sex, race/ethnicity and immigrant generation. Among first-generation immigrants, although parental education was not associated with adult BMI, an immigrant's own education attainment was inversely associated with BMI (β=-2.6 kg/m(2); SE=0.9, p<0.01). In addition, upward educational mobility was associated with lower adult mean BMI than remaining low SES (β=-2.5 kg/m(2); SE=1.2, p<0.05). In contrast, among US-born respondents, college education in adulthood did not attenuate the negative association between parental education and adult BMI. Although an SES gradient emerged in adulthood for immigrants, remaining low SES from adolescence to adulthood was not associated with loss of health advantage relative to US-born respondents of US-born parents of similar SES. Immigrants were able to translate higher SES in adulthood into a lower adult mean BMI regardless of childhood SES, whereas the consequences of lower childhood SES had a longer reach even among the upwardly mobile US born. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Changes in use of types of tobacco products by pack sizes and price segments, prices paid and consumption following the introduction of plain packaging in Australia.

PubMed

Scollo, Michelle; Zacher, Meghan; Coomber, Kerri; Bayly, Megan; Wakefield, Melanie

2015-04-01

To describe changes among smokers in use of various types of tobacco products, reported prices paid and cigarette consumption following the standardisation of tobacco packaging in Australia. National cross-sectional telephone surveys of adult smokers were conducted from April 2012 (6 months before transition to plain packaging (PP)) to March 2014 (15 months afterwards). Multivariable logistic regression assessed changes in products, brands and pack types/sizes; multivariable linear regression examined changes in inflation-adjusted prices paid and reported cigarette consumption between the pre-PP and three subsequent periods-the transition phase, PP year 1 and PP post-tax (post a 12.5% tax increase in December 2013). The proportion of current smokers using roll-your-own (RYO) products fluctuated over the study period. Proportions using value brands of factory-made (FM) cigarettes increased from pre-PP (21.4%) to PP year 1 (25.5%; p=0.002) and PP post-tax (27.8%; p<0.001). Inflation-adjusted prices paid increased in the PP year 1 and PP post-tax phases; the largest increases were among premium FM brands, the smallest among value brands. Consumption did not change in PP year 1 among daily, regular or current smokers or among smokers of brands in any market segment. Consumption among regular smokers declined significantly in PP post-tax (mean=14.0, SE=0.33) compared to PP year 1 (mean=14.8, SE=0.17; p=0.037). Introduction of PP was associated with an increase in use of value brands, likely due to increased numbers available and smaller increases in prices for value relative to premium brands. Reported consumption declined following the December 2013 tax increase. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Ethnic and sex differences in skeletal maturation among the Birth to Twenty cohort in South Africa.

PubMed

Cole, Tim J; Rousham, Emily K; Hawley, Nicola L; Cameron, Noel; Norris, Shane A; Pettifor, John M

2015-02-01

To examine ethnic and sex differences in the pattern of skeletal maturity from adolescence to adulthood using a novel longitudinal analysis technique (SuperImposition by Translation And Rotation (SITAR)). Johannesburg, South Africa. 607 boys and girls of black as well as white ethnicity from the Birth to Twenty bone health study, assessed annually from 9 to 20 years of age. Bone maturity scores (Tanner-Whitehouse III radius, ulna, and short bones (TW3 RUS)) assessed longitudinally from hand-wrist radiographs were used to produce individual and mean growth curves of bone maturity and analysed by the SITAR method. The longitudinal analysis showed that black boys matured later by 7.0 SE 1.6 months (p<0.0001) but at the same rate as white boys, whereas black girls matured at the same age but at a faster rate than white girls (by 8.7% SE 2.6%, p=0.0007). The mean curves for bone maturity score consistently showed a midpubertal double kink, contrasting with the quadratic shape of the commonly used reference centile curves for bone maturity (TW3). Skeletal maturity was reached 1.9 years earlier in girls than boys, and the pattern of maturation differed between the sexes. Within girls, there were no ethnic differences in the pattern or timing of skeletal maturity. Within boys, however, skeletal maturity was delayed by 7 months in black compared with white ethnicity. Skeletal maturation, therefore, varies differentially by sex and ethnicity. The delayed maturity of black boys, but not black girls, supports the hypothesis that boys have greater sensitivity to environmental constraints than girls. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Integration of somatic mutation, expression and functional data reveals potential driver genes predictive of breast cancer survival.

PubMed

Suo, Chen; Hrydziuszko, Olga; Lee, Donghwan; Pramana, Setia; Saputra, Dhany; Joshi, Himanshu; Calza, Stefano; Pawitan, Yudi

2015-08-15

Genome and transcriptome analyses can be used to explore cancers comprehensively, and it is increasingly common to have multiple omics data measured from each individual. Furthermore, there are rich functional data such as predicted impact of mutations on protein coding and gene/protein networks. However, integration of the complex information across the different omics and functional data is still challenging. Clinical validation, particularly based on patient outcomes such as survival, is important for assessing the relevance of the integrated information and for comparing different procedures. An analysis pipeline is built for integrating genomic and transcriptomic alterations from whole-exome and RNA sequence data and functional data from protein function prediction and gene interaction networks. The method accumulates evidence for the functional implications of mutated potential driver genes found within and across patients. A driver-gene score (DGscore) is developed to capture the cumulative effect of such genes. To contribute to the score, a gene has to be frequently mutated, with high or moderate mutational impact at protein level, exhibiting an extreme expression and functionally linked to many differentially expressed neighbors in the functional gene network. The pipeline is applied to 60 matched tumor and normal samples of the same patient from The Cancer Genome Atlas breast-cancer project. In clinical validation, patients with high DGscores have worse survival than those with low scores (P = 0.001). Furthermore, the DGscore outperforms the established expression-based signatures MammaPrint and PAM50 in predicting patient survival. In conclusion, integration of mutation, expression and functional data allows identification of clinically relevant potential driver genes in cancer. The documented pipeline including annotated sample scripts can be found in http://fafner.meb.ki.se/biostatwiki/driver-genes/. yudi.pawitan@ki.se Supplementary data are available at Bioinformatics online. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Psychological stress and short-term hospitalisations or death in patients with heart failure.

PubMed

Endrighi, Romano; Waters, Andrew J; Gottlieb, Stephen S; Harris, Kristie M; Wawrzyniak, Andrew J; Bekkouche, Nadine S; Li, Yisheng; Kop, Willem J; Krantz, David S

2016-06-29

Standard predictors do not fully explain variations in the frequency and timing of heart failure (HF) adverse events (AEs). Psychological stress can trigger acute cardiovascular (CV) events, but it is not known whether stress can precipitate AEs in patients with HF. We investigated prospective associations of psychological stress with AEs in patients with HF. 144 patients with HF (77% male; 57.5±11.5, range 23-87 years, left ventricular ejection fraction ≤40%) were longitudinally evaluated for psychological stress (Perceived Stress Scale) and AEs (CV hospitalisations/death) at 2-week intervals for 3 months and at 9-month follow-up. 42 patients (29.2%) had at least one CV hospitalisation and nine (6.3%) died. Patients reporting high average perceived stress across study measurements had a higher likelihood of AEs during the study period compared with those with lower stress (odds ratio=1.10, 95% confidence interval=1.04 to 1.17). In contrast to average levels, increases in stress did not predict AEs (p=0.96). Perceived stress was elevated after a CV hospitalisation (B=2.70, standard error (SE)=0.93, p=0.004) suggesting that CV hospitalisations increase stress. Subsequent analysis indicated that 24 of 38 (63%) patients showed a stress increase following hospitalisation. However, a prospective association between stress and AEs was present when accounting for prior hospitalisations (B=2.43, SE=1.23, p=0.05). Sustained levels of perceived stress are associated with increased risk of AEs, and increased distress following hospitalisation occurs in many, but not all, patients with HF. Patients with chronically high stress may be an important target group for HF interventions aimed at reducing hospitalisations. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

News from Online: More Spectroscopy

NASA Astrophysics Data System (ADS)

Sweeney Judd, Carolyn

1999-09-01

Absorption (one of three tools) (http://mc2.cchem.berkeley.edu/Chem1A/solar/applets/absorption/ index.html).

Evaporative cooling in a Bose-Einstein condensation ( http://www.colorado.edu/physics/2000/applets/bec.html). Let's start with the spectrum--the electromagnetic spectrum, of course. Go to the EMSpectrum Explorer at http://mc2.cchem.berkeley.edu/chemcnx/light_energy/EMSpectrum /emspectrum.html. Not only do you get information about wavelength, frequency, and energy, but you also get a handy converter that will calculate frequency, wavelength, and energy when one value is entered. And there is more. For example, clicking on red light of 680 nanometers reveals that mitochondria, the power plants of cells, are about the same size as this wavelength, which is also used for photosynthesis. Interesting food for thought! From the EMSpectrum Explorer, go to the Light and Energy page at http://mc2.cchem.berkeley.edu/chemcnx/light_energy/index.html for three Colors of Light Tools. The Color from Emission tool ( http://mc2.cchem.berkeley.edu/chemcnx/light_energy/applets/emission/index.html) illustrates additive color by mixing differing amounts of Red, Blue, and Green light. Then look at the Color from Absorption tool at http://mc2.cchem.berkeley.edu/chemcnx/light_energy/applets/absorption/index.html. The image from the applet shows the white beam and three filters. Take out the blue, green, and red components by altering the scroll bars or text boxes. The third tool, Removing Color with a Single Filter from Colored Light at http://mc2.cchem.berkeley.edu/chemcnx/light_energy/applets/single/index.html, uses a single filter to take out various colors. Excellent for explaining the theory behind the operation of a basic spectrometer. The Light and Energy tools module, which received support from the National Science Foundation, has been developed under the direction of the ChemLinks Coalition--headed by Beloit College; and The ModularChem Consortium, MC2, headed by the University of California at Berkeley. The Project Director is Marco Molinaro from the University of California at Berkeley; the Project Manager is Susan Walden; Susan Ketchner and Leighanne McConnaughey are also members of the team for this excellent teaching site. For your information, all of the applets will soon be moving, along with the MC2 site, but the old addresses will still work. The next place to explore is Physics 2000 at http://www.colorado.edu/physics/2000/introduction.html. The introductory graphic is a harbinger of good things to come: move the negatively charged particle and see the water molecule spin in response to the position of the charged particle. One goal of the Physics 2000 Educational Initiative is to make physics more accessible to students and people of all ages. Sounds like a good goal for all sciences! One of the first sections is called Einstein's Legacy. Here you can find spectral lines explained in terms of team colors for rival football squads ( http://www.colorado.edu/physics/2000/quantumzone/index.html). Choose from 20 elements to see characteristic emission spectra. The cartoon teachers and students help explain emission spectra. Great applets compare the Bohr atom and the Schrödinger model as well as emission and absorption ( http://www.colorado.edu/physics/2000/quantumzone/schroedinger.html). Einstein's Legacy has many topics: X-rays and CAT Scans, Electromagnetic Waves and Particles, the Quantum Atom, Microwave Ovens, Lasers, and TV & Laptop Screens. Several topics also have sections for the advanced student. One of those advanced sections is part of the second major section of Physics 2000: The Atomic Lab. Two topics are Interference Experiments and Bose-Einstein Condensate. An applet illustrating Laser Cooling is at http://www.colorado.edu/physics/2000/bec/lascool1.html. Next go on to Evaporative Cooling at http://www.colorado.edu/physics/2000/bec/evap_cool.html. The cartoon professors begin the explanation with a picture of steam rising from a cup of hot coffee. Next is an applet with atoms in a parabolic magnetic trap at http://www.colorado.edu/physics/2000/applets/bec.html. The height of the magnetic trap can be changed in order to allow for escape of the most energetic atoms, resulting in cooling so that the Bose-Einstein Condensate is formed. Physics 2000 demands robust computing power. Check the system requirements on the introductory screen before venturing too far into this site. Martin V. Goldman, from the University of Colorado at Boulder, is the Director of Physics 2000, which received support from the Colorado Commission on Higher Education and the National Science Foundation. David Rea is the Technical Director, and many others help make this excellent site possible. Mark your calendars: October 31 through December 3, 1999! Bookmark this site-- http://www.ched-ccce.org/confchem/1999/d/index.html --and sign up. The Winter 1999 CONFCHEM Online Conference will focus on Developments in Spectroscopy and Innovative Strategies for Teaching Spectroscopy in the Undergraduate Curriculum. Scott Van Bramer of Widener University is the conference chair. Experts will present six papers, each to be followed by online discussions. CONFCHEM Online Conferences are sponsored by the American Chemical Society Division of Chemical Education's Committee on Computers in Chemical Education (CCCE). Several Online Conferences are held each year--all are well worth your time. World Wide Web Addresses EMSpectrum Explorer http://mc2.cchem.berkeley.edu/chemcnx/light_energy/EMSpectrum/emspectrum.html Light and Energy http://mc2.cchem.berkeley.edu/chemcnx/light_energy/index.html Emission Spectrum Java Applet http://mc2.cchem.berkeley.edu/chemcnx/light_energy/applets/emission/index.html Absorption Java Applet http://mc2.cchem.berkeley.edu/chemcnx/light_energy/applets/absorption/index.html Removing Color with a Single Filter from Colored Light http://mc2.cchem.berkeley.edu/chemcnx/light_energy/applets/single/index.html Physics 2000 http://www.colorado.edu/physics/2000/introduction.html Einstein's Legacy: Spectral lines http://www.colorado.edu/physics/2000/quantumzone/index.html Einstein's: Schrödinger's Atom http://www.colorado.edu/physics/2000/quantumzone /schroedinger.html The Atomic Lab: Laser Cooling http://www.colorado.edu/physics/2000/bec/lascool1.html The Atomic Lab: Evaporative Cooling in a Bose­Einstein Condensation http://www.colorado.edu/physics/2000/bec/evap_cool.html The Winter 1999 CONFCHEM Online Conference will focus on Developments in Spectroscopy and Innovative Strategies for Teaching Spectroscopy in the Undergraduate Curriculum http://www.ched-ccce.org/confchem/1999/d/index.html access date for all sites: July 1999

Selenium speciation in paired serum and cerebrospinal fluid samples of sheep.

PubMed

Humann-Ziehank, Esther; Ganter, Martin; Michalke, Bernhard

2016-01-01

This study was performed to characterise selenium (Se) and Se species in cerebrospinal fluid (CSF) of sheep and its relation to the respective Se concentrations in serum. Paired samples from 10 adult sheep were used for the study. Five sheep were fed a diet with a marginal Se concentration of <0.05mg Se/kg diet dry weight (dw, Se(-)), and five animals were fed the same diet supplemented with sodium selenite revealing a concentration of 0.2mg Se/kg diet dw (Se(+)). The feeding strategy was conducted for two years; The results on metabolic effects were published previously. At the end of the feeding period, paired samples of serum and CSF were collected and analysed using ion exchange chromatography inductively coupled plasma-dynamic reaction cell-mass spectrometry (IEC-ICP-DRC-MS) technique for total Se concentration and concentrations of Se species. Albumin concentrations were analysed additionally. The feeding strategy caused significant differences (p<0.01) in serum Se concentrations with 33.1±5.11μg Se/l in the Se(-) group and 96.5±18.3μg Se/l in the Se(+) group, respectively. The corresponding total Se concentrations in CSF were 4.38±1.02μg Se/l and 6.13±1.64μg Se/l in the Se(-) and the Se(+) group, respectively, missing statistical significance (p=0.077). IEC-ICP-DRC-MS technique was able to differentiate the Se species selenoprotein P-bound Se (SePP), selenomethionine, glutathione peroxidase-bound Se (Se-GPx), selenocystine, thioredoxin reductase-bound Se, ovine serum albumin-bound Se (Se-OSA), SeIV and SeVI in ovine serum and CSF. Quantitatively, SePP is the main selenoprotein in ovine serum followed by Se-GPx. The CSF/blood ratio of albumin (QAlbumin) reflected a physiological function of the blood-CSF barrier in all sheep. QSe-species were higher than QAlbumin both feeding groups, supporting the hypothesis of local production of Se species in the brain. Significant positive regression lines for CSF vs. serum were found for albumin and Se-OSA only, suggesting a role of albumin to convey Se across the blood-CSF barrier. The ovine model, together with the IEC-ICP-DRC-MS technique to characterise the Se species, might be a worthwhile model for further studies as repeated sample collection as well as modification of the nutritional status is feasible and effective. Copyright © 2015 Elsevier GmbH. All rights reserved.

MEST-Do the ``rubble-pile'' asteroid-1950 DA, with low 1700 kg/m3 density, has a structure with spacetime center?

NASA Astrophysics Data System (ADS)

Cao, Dayong

2015-04-01

According to Einstein's equation and observation of flat universe, the paper gives new ideas both of dark massenergy and spacetime center, and supporses that some asteroids were comets which have spacetime center, and some comets were wraped up by rock in 2012. It explains of a observation about low density of the asteroid-1950 DA by spacetime center of the asteroid. (see Ben Rozitis, ``Cohesive forces prevent the rotational breakup of rubble-pile asteroid (29075) 1950 DA,'' http://www. nature.com / nature / journal / v512 / n7513/full/nature13632.html) It also can explain of a rock hull of 67P/Churyumov-Gerasimenko. (see Jonathan O'Callaghan, ``Comets are like deep fried ICE CREAM: Nasa ice-box experiment confirms 67P is hard on the outside but fluffy on the inside,'' http://www.dailymail.co.uk/sciencetech/article-2949020/Comets-like-deep-fried-ICE-CREAM-Nasa-ice-box-experiment-confirms-67P-hard-outside-fluffy-inside.html) (See Dayong Cao, ``MEST-The dark hole, dark comet and dark matter are the space-time center'' and ``MEST- avoid next extinction by a space-time effect'') http://meetings.aps.org/link/BAPS.2014.APR.L1.3 http://meetings.aps.org/link/BAPS.2014.APR.L1.2 http://meetings.aps.org/link/BAPS.2015.APR.L1.2 http://meeting.aps.org/Meeting/CAL12/Session/H1.8 http://meetings.aps.org/link/BAPS.2012.APR.K1.79

Accuracy of Monte Carlo photon transport simulation in characterizing brachytherapy dosimeter energy-response artefacts

NASA Astrophysics Data System (ADS)

Das, R. K.; Li, Z.; Perera, H.; Williamson, J. F.

1996-06-01

Practical dosimeters in brachytherapy, such as thermoluminescent dosimeters (TLD) and diodes, are usually calibrated against low-energy megavoltage beams. To measure absolute dose rate near a brachytherapy source, it is necessary to establish the energy response of the detector relative to that of the calibration energy. The purpose of this paper is to assess the accuracy of Monte Carlo photon transport (MCPT) simulation in modelling the absolute detector response as a function of detector geometry and photon energy. We have exposed two different sizes of TLD-100 (LiF chips) and p-type silicon diode detectors to calibrated , HDR source and superficial x-ray beams. For the Scanditronix electron-field diode, the relative detector response, defined as the measured detector readings per measured unit of air kerma, varied from (40 kVp beam) to ( beam). Similarly for the large and small chips the same quantity varied from and , respectively. Monte Carlo simulation was used to calculate the absorbed dose to the active volume of the detector per unit air kerma. If the Monte Carlo simulation is accurate, then the absolute detector response, which is defined as the measured detector reading per unit dose absorbed by the active detector volume, and is calculated by Monte Carlo simulation, should be a constant. For the diode, the absolute response is . For TLDs of size the absolute response is and for TLDs of it is . From the above results we can conclude that the absolute response function of detectors (TLDs and diodes) is directly proportional to absorbed dose by the active volume of the detector and is independent of beam quality.

Effects of Selenium Supplementation on the Diabetic Condition Depend on the Baseline Selenium Status in KKAy Mice.

PubMed

Febiyanto, Novian; Yamazaki, Chiho; Kameo, Satomi; Sari, Dian K; Puspitasari, Irma M; Sunjaya, Deni K; Herawati, Dewi M D; Nugraha, Gaga I; Fukuda, Toshio; Koyama, Hiroshi

2018-01-01

Oxidative stress in obesity leads to insulin resistance in type 2 diabetes. Some selenoproteins possess antioxidant properties, suggesting that selenium (Se) may protect against type 2 diabetes; however, evidence from epidemiological studies is contradictory. We hypothesized that Se status before supplementation (baseline) contributes to the supplementation outcome. This study aimed to clarify the influence of baseline Se status on the effect of Se supplementation on the diabetic condition. Six-week-old KKAy mice were fed a diet without supplemental Se or with 0.1 ppm Se in the form of L-selenomethionine (SeM) for 2 weeks to create low-Se and sufficient-Se baseline statuses, respectively. For the next 4 weeks, low-Se mice were given a SeM (0.5 ppm Se)-supplemented diet, and sufficient-Se mice were given either a SeM (0.5 ppm Se)- or sodium selenite (0.5 ppm Se)-supplemented diet; control groups continued on baseline diets. Serum Se concentrations, glutathione peroxidase (GPx) activities, adiponectin levels, glucose tolerance, and insulin sensitivity were analyzed. All mice became diabetic during the 2-week baseline induction period. At the end of the supplementation period, Se-receiving groups demonstrated significantly higher Se concentrations and GPx activities than their respective controls. Sufficient-Se mice receiving SeM had lower blood glucose levels and better insulin sensitivity than control and sodium selenite-receiving mice, whereas low-Se mice receiving SeM showed no such improvements compared with their controls. Our results suggest that Se supplementation in the form of SeM may help prevent type 2 diabetes aggravation in people taking the 55 μg/day Se recommended dietary allowance.

Asymmetry and Electronegativity in the Electron Capture Activation of the Se-Se Bond: σ*(Se-Se) vs σ*(Se-X).

PubMed

Gámez, José A; Yáñez, Manuel

2010-10-12

The effects of electron capture on the structure of XSeSeX' diselenide derivatives in which the substituents attached to the selenium atoms have different electronegativities have been investigated at different levels of theory, namely, DFT, MP2, CCSD, G2, and CASSCF/CASPT2. An analysis of the bonding changes upon electron attachment shows that when the diselenides bear low-electronegativity substituents, the Se-Se bond becomes activated upon electron capture, as previous studies have shown. However, this is no longer the case for very electronegative substituents, where this bond remains practically unaltered and is the Se-X bond the one which becomes strongly activated through a preferential population of the σ*(Se-X) antibonding orbital rather than the σ*(Se-Se) one. When this is the case, several anionic species are also encountered, namely, stretched, bent, and book structures. The present findings are similar to those obtained for a series of analogous disulfide compounds, which points out that these results are not unique and could be extrapolated to a wider range of compounds than the ones covered here. The Se-Se (Se-X) linkage in CH3SeSeOH, CH3SeSeF, FSeSeOH, and FSeSeF bears some of the characteristics of the so-called charge-shift bonds, with a clear charge fluctuation between both selenium atoms. This is more evident in their anions where the bonding reflects the important contribution of the ionic resonant forms Se-Se(-) ↔ (-)Se-Se vs the covalent component Se∴Se. This resonance changes with the nature of the substituents but also depends on the asymmetry of the substitution.

Selenium speciation in Lower Cambrian Se-enriched strata in South China and its geological implications

NASA Astrophysics Data System (ADS)

Fan, Haifeng; Wen, Hanjie; Hu, Ruizhong; Zhao, Hui

2011-12-01

To understand the impact of Selenium (Se) into the biogeochemical cycle and implications for palaeo-redox environment, a sequential extraction method was utilized for samples including black shales, cherts, a Ni-Mo-Se sulfide layer, K-bentonite and phosphorite from Lower Cambrian Se-enriched strata in southern China. Seven species (water-soluble, phosphate exchangeable, base-soluble, acetic acid-soluble, sulfide/selenide associated, residual Se) and different oxidation states (selenate Se(VI), selenite Se(IV), organic Se, Se (0) and mineral Se(-II)) were determinated in this study. We found that the Ni-Mo-Se sulfide layer contained a significantly greater amount of Se(-II) associated with sulfides/selenides than those in host black shales and cherts. Furthermore, a positive correlation between the degree of sulfidation of iron (DOS) and the percentage of the sulfide/selenide-associated Se(-II) was observed for samples, which suggests the proportion of sulfide/selenide-associated Se(-II) could serve as a proxy for palaeo-redox conditions. In addition, the higher percentage of Se(IV) in K-bentonite and phosphorite was found and possibly attributed to the adsorption of Se by clay minerals, iron hydroxide surfaces and organic particles. Based on the negative correlations between the percentage of Se(IV) and that of Se(-II) in samples, we propose that the K-bentonite has been altered under the acid oxic conditions, and the most of black shale (and cherts) and the Ni-Mo-Se sulfide layer formed under the anoxic and euxinic environments, respectively. Concerning Se accumulation in the Ni-Mo-Se sulfide layer, the major mechanism can be described by (1) biotic and abiotic adsorption and further dissimilatory reduction from oxidized Se(VI) and Se(IV) to Se(-II), through elemental Se, (2) contribution of hydrothermal fluid with mineral Se(-II).

[Preventive effects of 4 Se-enriched plants on rat stomach cancer induced by MNNG--3. Se accumulation and distribution in rats of different selenium resources for prevention of stomach cancer].

PubMed

Yang, Wenije; Chen, Jing; Li, Weidong; Chen, Xiaobin

2008-07-01

To investigate the accumulation and distribution of blood and tissue Se in rats with long-term and high-dose of Se supplementation by four Se-enriched plants (Se-enriched garlic, Se-enriched broccoli, Se-enriched green kale and Se-enriched red kale) in the N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced stomach cancer model. Ninety rats were fed by basal diet for a week, divided equally into the control, MNNG and seven Se supplementation groups. Rats were daily given 15 mg/kg bw of MNNG for ten days except those in the control group, and rats in five Se-enriched plant treatment groups were daily given 150 or 300 microg Se/kg of bw of the plant suspension by gavage for 17 weeks. Rats were sacrificed at the end of 18th week, the Se contents of blood, red blood cell, plasma, liver, kidney, spleen, heart, brain and testicle were determined. The Se contents of liver and kidney in rats supplemented by Se-enriched garlic were significantly lower than those in rats supplemented by Se-enriched broccoli and two Se-enriched kales, and the Se contents of red blood cell and spleen higher than those in rats supplemented by Se-enriched broccoli and two Se-enriched kales. The data primarily shows that the differences of the accumulation and distribution of blood and tissue Se in rats are related to the supplemented plant Se components, and that lower Se accumulation of the liver and kidney in rats supplemented by Se-enriched garlic than by other plants may be one of Se safety indices of Se-enriched garlic.

Optical studies of CdSe/HgSe and CdSe/Ag2Se core/shell nanoparticles embedded in gelatin

NASA Astrophysics Data System (ADS)

Azhniuk, Yu M.; Dzhagan, V. M.; Raevskaya, A. E.; Stroyuk, A. L.; Kuchmiy, S. Ya; Valakh, M. Ya; Zahn, D. R. T.

2008-11-01

CdSe/HgSe and CdSe/Ag2Se core-shell nanoparticles are obtained by colloidal synthesis from aqueous solutions in the presence of gelatin. Optical absorption, luminescence, and Raman spectra of the nanoparticles obtained are measured. The variation of the optical spectra of CdSe/HgSe and CdSe/Ag2Se core-shell nanoparticles with the shell thickness is discussed. Sharp non-monotonous variation of the photoluminescence spectra at low shell coverage is observed.

Structure and Properties of Modified and Charge-Compensated Chalcogenide Glasses in the Na/Ba-Ga-Ge Selenide System

NASA Astrophysics Data System (ADS)

Mao, Alvin W.

Chalcogenide glasses exhibit unique optical properties such as infrared transparency owing to the low-phonon energies, optical non-linearity, and photo-induced effects that have important consequences for a wide range of technological applications. However, to fully utilize these properties, it is necessary to better understand the atomic-scale structure and structure-property relationships in this important class of materials. Of particular interest in this regard are glasses in the stoichiometric system Na2Se/BaSe--Ga 2Se3--GeSe2 as they are isoelectronic with the well-studied, oxide glasses of the type M2O(M'O)--Al 2O3--SiO2 (M = alkali, M' = alkaline earth). This dissertation investigates the structure of stoichiometric Na 2Se/BaSe--Ga2Se3--GeSe2 and off-stoichiometric BaSe--Ga2Se3--GeSe 2+/-Se glasses using a combination of Fourier-transform Raman and solid state nuclear magnetic resonance (NMR) spectroscopies. The spectroscopic data is then compared to composition-dependent trends in physical properties such as density, optical band gap, glass transition temperature, and melt fragility to develop predictive structural models of the short- and intermediate-range order in the glass network. These models significantly improve our current understanding of the effects of modifier addition on the structure and properties of chalcogenide glasses, and thus enable a more efficient engineering of these highly functional materials for applications as solid electrolytes in batteries or as optical components in infrared photonics. In general, the underlying stoichiometric Ga2Se3--GeSe 2 network consists primarily of corner-sharing (Ga/Ge)Se4 tetrahedra, where the coordination numbers of Ga, Ge, and Se are 4, 4, and 2, respectively. Some edge-sharing exists, but this configuration is relatively unstable and its concentration tends to decrease with any deviation from the GeSe2 composition. Due to the tetrahedral coordination of Ga, the initial addition of Se-deficient Ga2Se3 to GeSe 2 results in the preferential formation of Ge-Ge bonds, which are distributed such that the clustering of ethane-like (Se3)Ge-Ge(Se3) units is avoided to the maximum extent. This behavior is entirely consistent with the continuously-alloyed structural scenario of chalcogenide glasses. However, for contents of Ga2Se3 greater than about 25--30 mol%, the avoidance of Ga-Ga and mixed Ga-Ge bonds results in the appearance of three-coordinated Se as an alternate mechanism to accommodate the Se deficiency. The addition of either Na2Se or BaSe to Ga2Se 3--GeSe2 glasses introduces an ionic bonding character to an otherwise largely covalently bonded network. As a result, the structure responds by adopting characteristics of the charge-compensated structural scenario of oxide glasses. In the stoichiometric Na2Se/BaSe--Ga 2Se3--GeSe2 glasses, the ratio of Na 2Se/BaSe:Ga2Se3 = 1 serves as a chemical threshold, where the network consists predominantly of corner-sharing (Ga/Ge)e4 tetrahedra, and the charge on the Na(Ba) cations is balanced by the GaSe4- tetrahedra. For glasses with Na 2Se/BaSe:Ga2Se3 < 1, the addition of Se-deficient Ga2Se3 induces the formation of Ge-Ge bonds. However, for glasses with Na2Se/BaSe:Ga2Se3 > 1, the addition of Na2Se/BaSe results in the formation of non-bridging Se atoms, which break up the connectivity of the glassy network. The major difference between the modifying elements Na and Ba is that the high field strength of the Ba cation induces a higher degree of chemical disorder in the glass network. This conclusion is evidenced by the presence of some Ge-Ge bonds in BaSe--Ga2Se3--GeSe2 glasses even at the chemical threshold composition of BaSe:Ga2Se3 = 1. The structural duality of the Na2Se/BaSe--Ga2Se 3--GeSe2 system is best observed in the off-stoichiometric BaSe--Ga2Se3--GeSe2+/-Se glasses. Here, the removal of Se from a stoichiometric glass with BaSe:Ga2Se 3 > 1 results in Ge-Ge bonds, while its addition in excess of stoichiometry forms Se-Se bonds. Although such behavior is consistent with the continuously-alloyed structural model, it should be contrasted with the response of the network to the removal or addition of BaSe. In the latter case especially, the network responds with the formation of non-bridging Se atoms, which is reminiscent of the charge-compensated structural scenario. The aforementioned structural conclusions are supported by trends in physical properties. Of all the properties measured, the glass transition temperature Tg responds most predictably to changes in glass structure in the sense that the removal of heteropolar (Ga/Ge)-Se bonds from the glassy network consistently results in a decrease in Tg. Indeed, Tg is observed to be maximized around chemical threshold compositions that are expected to have a fully-connected network of (Ga/Ge)Se¬4 tetrahedra. The formation of homopolar Ge-Ge bonds causes Tg to drop by ~40--80 °C, while the formation of Se-Se and/or non-bridging Se causes Tg to decrease by at least 120 °C. Trends in density reflect both the packing efficiency of the structural units within the glassy network as well as the masses of the constituent elements, and are generally observed to increase or decrease monotonically. As a result, an increase in density is associated with: 1) the removal of inefficiently packed structural units such as edge-sharing tetrahedra, 2) the formation of efficiently packed units such as three-coordinated Se atoms, 3) the removal of lighter elements like Na, and 4) the addition of heavier elements like Ba. Optical band gap is related to the bonding character within the glassy network, and tends to decrease as the bonding character becomes increasingly metallic. Therefore, a decrease in optical band gap is observed with the formation of homopolar Ge-Ge bonds when Ga2Se3 is added to GeSe2. However, the stoichiometric BaSe--Ga2Se 3--GeSe2 glasses show an anomaly in this regard because optical band gap decreases with the addition of BaSe, and consequently the removal of Ge-Ge bonds. This observation was ascribed instead to the formation of Ba-Se bonds, which are associated with a lower bandgap compared to the (Ga/Ge)-Se bonds that they replace. Finally, there is no straightforward structural explanation for trends in fragility, because it is related to the number of structural configurations dynamically available to the supercooled liquid. In the binary Ga2Se3--GeSe2 glasses, the fragility tends to increase with the formation of homopolar Ge-Ge bonds, which is consistent with other chalcogenide systems in which fragility increases with the removal of heteropolar bonds within corner-sharing tetrahedra and pyramids. In the stoichiometric BaSe--Ga2Se3--GeSe2 glasses on the other hand, a shift in trend near the compositions where BaSe:Ga 2Se3 = 1 coincides with a structural shift between the formation of Ge-Ge bonds and Se-Se/non-bridging Se.

Selenium Assimilation and Volatilization from Selenocyanate-Treated Indian Mustard and Muskgrass1

PubMed Central

de Souza, Mark P.; Pickering, Ingrid J.; Walla, Michael; Terry, Norman

2002-01-01

Selenocyanate (SeCN−) is a major contaminant in the effluents from some oil refineries, power plants, and in mine drainage water. In this study, we determined the potential of Indian mustard (Brassica juncea) and muskgrass (a macroalga, Chara canescens) for SeCN− phytoremediation in upland and wetland situations, respectively. The tolerance of Indian mustard to toxic levels of SeCN− was similar to or higher than other toxic forms of Se. Indian mustard treated with 20 μm SeCN− removed 30% (w/v) of the Se supplied in 5 d, accumulating 554 and 86 μg of Se g−1 dry weight in roots and shoots, respectively. Under similar conditions, muskgrass removed approximately 9% (w/v) of the Se supplied as SeCN− and accumulated 27 μg of Se g−1 dry weight. A biochemical pathway for SeCN− degradation was proposed for Indian mustard. Indian mustard and muskgrass efficiently degraded SeCN− as none of the Se accumulated by either organism remained in this form. Indian mustard accumulated predominantly organic Se, whereas muskgrass contained Se mainly as selenite and organic Se forms. Indian mustard produced volatile Se from SeCN− in the form of less toxic dimethylselenide. Se volatilization by Indian mustard accounted for only 0.7% (w/v) of the SeCN− removed, likely because the biochemical steps in the production of dimethylselenide from organic Se were rate limiting. Indian mustard is promising for the phytoremediation of SeCN−-contaminated soil and water because of its remarkable abilities to phytoextract SeCN− and degrade all the accumulated SeCN− to other Se forms. PMID:11842165

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Asiago spectroscopic classification of three SNe

NASA Astrophysics Data System (ADS)

Elias-Rosa, N.; Cappellaro, E.; Benetti, S.; Tomasella, L.; Ochner, P.; Pastorello, A.; Tartaglia, L.; Terreran, G.; Turatto, M.

2015-09-01

The Asiago Transient Classification Program (Tomasella et al. 2014, AN, 335, 841) reports the spectroscopic classification of three SNe. Informations on these transients are also available from the "Bright Supernova" website (http://www.rochesterastronomy.org/snimages/), the CBAT Transient Object Followup Reports (http://www.cbat.eps.harvard.edu/index.html) and All-Sky Automated Survey for Supernovae (http://www.astronomy.ohio-state.edu/~assassin/index.shtml).

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....2001(a)(1)(iii) and the instructions on the Commission's Web site http:[sol][sol]www.ferc.gov/docs... registration, using the eComment system at http:[sol][sol]www.ferc.gov/docs-filing/ecomment.asp. You must... http:[sol][sol]www.ferc.gov/docs-filing/ elibrary.asp. Enter the docket number (P-14248-000) in the...

76 FR 10054 - Notice of Availability: Notice of Technical Correction to the Notice of Funding Availability for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-23

...: Notice. SUMMARY: On January 20, 2011, HUD posted on http://www.Grants.gov , a Notice of Funding... Housing and Urban Development agency link on the Grants.gov/Find Web site at http://www.grants.gov/search/agency.do . A link to Grants.gov is also available on the HUD Web site at http://www.hud.gov/offices/adm...

Chromate Free Magnesium Gearbox Protection System

DTIC Science & Technology

2014-11-01

default.cfm?page=375 Ref 5: Rolls-Royce Front Frame example Ref 6: http://www.volksworld.com/blog/staff-blogs/jons-blog/stripping- down-a-donor- beetle ...www.fwtec.com/FW/nanosolution.html# Ref 10 http://www.arl.army.mil/www/default.cfm?page=375 Ref 5: Rolls-Royce Front Frame example Ref 6: http://www.volksworld.com/blog/staff-blogs/jons-blog/stripping- down-a-donor- beetle -engine/

Semantic Web Technologies for Mobile Context-Aware Services

DTIC Science & Technology

2006-03-01

for Context-Aware Service Provisioning 6 Communication toolkit (http, e-mail, IM, etc.) User interaction manager Platform manager White & yellow ...NAICS] North American Industry Classification System , http://www.census.gov/epcd/www/naics.html [OS00] Opermann, R., and Specht , M., A Context...toolkit (http, e-mail, IM, etc.) User interaction manager Platform manager White & yellow pages MAS administration toolkit N ET W O R K knowledge

41 CFR 302-5.13 - What methods may my agency use to reimburse me for househunting trip expenses?

Code of Federal Regulations, 2012 CFR

2012-07-01

... allowance at the standard CONUS rate (see http://www.gsa.gov/perdiem), for you and/or your spouse if you... rate by 5.00 (see http://www.gsa.gov/perdiem). (2) If you and your spouse both perform a househunting trip, together or separately, multiply the applicable locality per diem rate by 6.25 (see http://www...

41 CFR 302-5.13 - What methods may my agency use to reimburse me for househunting trip expenses?

Code of Federal Regulations, 2013 CFR

2013-07-01

... allowance at the standard CONUS rate (see http://www.gsa.gov/perdiem), for you and/or your spouse if you... rate by 5.00 (see http://www.gsa.gov/perdiem). (2) If you and your spouse both perform a househunting trip, together or separately, multiply the applicable locality per diem rate by 6.25 (see http://www...

Cyberpeace Through Cyberspace: Nation-Building Against Transnational Terrorism

DTIC Science & Technology

2010-12-01

Haiti,” The Seattle Times, January 27, 2010 at: http://seattletimes.nwsource.com/html/nationworld/2010910268_haiti28.html? syndication =rss (accessed...March 30, 2010 at: http://www.thebulletin.org/web-edition/ columnists /fissile-materials- working-group/reduce-the-civilian-use-of-heu-now (accessed...Bulletin of the Atomic Scientists, March 30, 2010. http://www.thebulletin.org/web- edition/ columnists /fissile-materials-working-group/reduce-the

Protecting Diplomats in Iraq: What Can the U.S. Department of State do to Improve it’s Management and Oversight of Security Contractors in Iraq

DTIC Science & Technology

2008-01-01

2004 Mission." Associated Press Financial Wire, October 24,2007, sec. Business News. http://proquest.com. Lee , Mattew. "Rice: New State Dept. Security...Front Page. http://proquest.com. Strobel , Warren P. "Iraq Panel Charges Feds Interference." Monterey County Herald, September 26,2007, sec. National. http

Lab Note: Training the Cyber Defensive Line

DTIC Science & Technology

2016-05-02

available at http://www.nextgov.com/cybersecurity/2013/03/how-many-cyberattacks-hit-united-states-last- year/61775/. 2 “Verizon 2015 Data Breach Investigation...at http://www.prnewswire.com/news-releases/verizon-2015- data - breach -investigations-report-finds- cyberthreats-are-increasing-in-sophistication-yet...Verizon’s Data Breach Investigations Report (available on request from http://www.verizonenterprise.com/DBIR/). The blue team must ensure that their

Exploration work function and optical properties of monolayer SnSe allotropes

NASA Astrophysics Data System (ADS)

Cui, Zhen; Wang, Xia; Ding, Yingchun; Li, Meiqin

2018-02-01

The work function and optical properties are investigated with density functional theory for three monolayer SnSe allotropes. The calculated results indicate that the α-SnSe, δ-SnSe, ε-SnSe are semiconductor with the band gaps of 0.90, 1.25, and 1.50 eV, respectively. Meanwhile, the work function of δ-SnSe is lower than α-SnSe and ε-SnSe, which indicates that the δ-SnSe can be prepared of photoemission and field emission nanodevices. More importantly, the α-SnSe, δ-SnSe, ε-SnSe with the large static dielectric constants are 4.22, 5.48, and 3.61, which demonstrate that the three monolayer SnSe allotropes can be fabricated the capacitor. In addition, the static refractive index of δ-SnSe is larger than α-SnSe and ε-SnSe. The different optical properties with three monolayer SnSe allotropes reveal that the allotropes can regulate the properties of the materials. Moreover, our researched results show that the three monolayer SnSe allotropes are sufficient for fabrication of optoelectronic nanodevices.

Magnetic fields from domestic appliances in the UK

NASA Astrophysics Data System (ADS)

Preece, A. W.; Kaune, W.; Grainger, P.; Preece, S.; Golding, J.

1997-01-01

In a survey of 50 UK homes the 50 Hz fundamental and harmonic magnetic fields generated by 806 domestic appliances found in the homes, and used regularly by mothers, were measured. Measurements were made in the direction of most likely access, and from the surface of the appliances. Mothers completed a questionnaire on the use of appliances and were monitored for 24 h so that acquired exposure could be compared with the measured ambient fields in the home. Appliances were measured at standard distances and an algorithm was used to calculate fields at 100 and 50 cm to remove room background contributions. A few appliances generated fields in excess of at 1 m: microwave cookers ; washing machines ; dishwashers ; some electric showers and can openers . Of continuously operating devices, only central heating pumps (), central heating boilers () and fish-tank air pumps () produced significant fields at 0.5 m. There were no obvious ways to group different types of appliances as high- or low-strength sources. Mothers spent on average about 4.5 h per day in the kitchen, where the strongest sources of magnetic field were located.

Thermoelectric properties of SrTiO3 nano-particles dispersed indium selenide bulk composites

NASA Astrophysics Data System (ADS)

Lee, Min Ho; Rhyee, Jong-Soo; Vaseem, Mohammad; Hahn, Yoon-Bong; Park, Su-Dong; Jin Kim, Hee; Kim, Sung-Jin; Lee, Hyeung Jin; Kim, Chilsung

2013-06-01

We investigated the thermoelectric properties of the InSe, InSe/In4Se3 composite, and SrTiO3 (STO) nano-particles dispersed InSe/In4Se3 bulk composites. The electrical conductivity of the InSe/In4Se3 composite with self-assembled phase separation is significantly increased compared with those of InSe and In4Se3-δ implying the enhancement of surface conductivity between grain boundaries. The thermal conductivity of InSe/In4Se3 composite is decreased compared to those of InSe. When the STO nano-particle dispersion was employed in the InSe/In4Se3 composite, a coherent interface was observed between nano-particle precipitates and the InSe bulk matrix with a reduction of the thermal conductivity.

Selenium speciation in wheat grain varies in the presence of nitrogen and sulphur fertilisers.

PubMed

Duncan, Elliott G; Maher, William A; Jagtap, Rajani; Krikowa, Frank; Roper, Margaret M; O'Sullivan, Cathryn A

2017-08-01

This study investigated whether selenium species in wheat grains could be altered by exposure to different combinations of nitrogen (N) and sulphur (S) fertilisers in an agronomic biofortification experiment. Four Australian wheat cultivars (Mace, Janz, Emu Rock and Magenta) were grown in a glasshouse experiment and exposed to 3 mg Se kg -1 soil as selenate (Se VI ). Plants were also exposed to 60 mg N kg -1 soil as urea and 20 mg S kg -1 soil as gypsum in a factorial design (N + S + Se; N + Se; S + Se; Se only). Plants were grown to maturity with grain analysed for total Se concentrations via ICP-MS and Se species determined via HPLC-ICP-MS. Grain Se concentrations ranged from 22 to 70 µg Se g -1 grain (dry mass). Selenomethionine (SeMet), Se-methylselenocystine (MeSeCys), selenohomolanthionine (SeHLan), plus a large concentration of uncharacterised Se species were found in the extracts from grains. SeMet was the major Se species identified accounting for between 9 and 24 µg Se g -1 grain. Exposure to different N and S fertiliser combinations altered the SeMet content of Mace, Janz and Emu Rock grain, but not that of Magenta. MeSeCys and SeHLan were found in far lower concentrations (<4 µg Se g -1 grain). A large component of the total grain Se was uncharacterisable (>30 % of total grain Se) in all samples. When N fertiliser was applied (with or without S), the proportion of uncharacterisable Se increased between 60 and 70 % of the total grain Se. The data presented here indicate that it is possible to alter the content of individual Se species in wheat grains via biofortification combined with manipulation of N and S fertiliser regimes. This has potential significance in alleviating or combating both Se deficiency and Se toxicity effects in humans.

Protective Effects of Cannabidiol against Seizures and Neuronal Death in a Rat Model of Mesial Temporal Lobe Epilepsy.

PubMed

Do Val-da Silva, Raquel A; Peixoto-Santos, Jose E; Kandratavicius, Ludmyla; De Ross, Jana B; Esteves, Ingrid; De Martinis, Bruno S; Alves, Marcela N R; Scandiuzzi, Renata C; Hallak, Jaime E C; Zuardi, Antonio W; Crippa, Jose A; Leite, Joao P

2017-01-01

The present study reports the behavioral, electrophysiological, and neuropathological effects of cannabidiol (CBD), a major non-psychotropic constituent of Cannabis sativa , in the intrahippocampal pilocarpine-induced status epilepticus (SE) rat model. CBD was administered before pilocarpine-induced SE (group SE+CBDp) or before and after SE (group SE+CBDt), and compared to rats submitted only to SE (SE group), CBD, or vehicle (VH group). Groups were evaluated during SE (behavioral and electrophysiological analysis), as well as at days one and three post-SE (exploratory activity, electrophysiological analysis, neuron density, and neuron degeneration). Compared to SE group, SE+CBD groups (SE+CBDp and SE+CBDt) had increased SE latency, diminished SE severity, increased contralateral afterdischarge latency and decreased relative powers in delta (0.5-4 Hz) and theta (4-10 Hz) bands. Only SE+CBDp had increased vertical exploratory activity 1-day post SE and decreased contralateral relative power in delta 3 days after SE, when compared to SE group. SE+CBD groups also showed decreased neurodegeneration in the hilus and CA3, and higher neuron density in granule cell layer, hilus, CA3, and CA1, when compared to SE group. Our findings demonstrate anticonvulsant and neuroprotective effects of CBD preventive treatment in the intrahippocampal pilocarpine epilepsy model, either as single or multiple administrations, reinforcing the potential role of CBD in the treatment of epileptic disorders.

Effect of selenium-enriched organic material amendment on selenium fraction transformation and bioavailability in soil.

PubMed

Wang, Dan; Dinh, Quang Toan; Anh Thu, Tran Thi; Zhou, Fei; Yang, Wenxiao; Wang, Mengke; Song, Weiwei; Liang, Dongli

2018-05-01

To exploit the plant byproducts from selenium (Se) biofortification and reduce environmental risk of inorganic Se fertilizer, pot experiment was conducted in this study. The effects of Se-enriched wheat (Triticum aestivum L.) straw (WS + Se) and pak choi (Brassica chinensis L.) (P + Se) amendment on organo-selenium speciation transformation in soil and its bioavailability was evaluated by pak choi uptake. The Se contents of the cultivated pak choi in treatments amended with the same amount of Se-enriched wheat straw and pak choi were 1.7 and 9.7 times in the shoots and 2.3 and 6.3 times in the roots compared with control treatment. Soil respiration rate was significantly increased after all organic material amendment in soil (p < 0.05), which accelerated the mineralization of organic materials and thus resulted in soluble Se (SOL-Se), exchangeable Se (EX-Se), and fulvic acid-bound Se (FA-Se) fraction increasing by 25.2-29.2%, 9-13.8%, and 4.92-8.28%, respectively. In addition, both Pearson correlation and cluster analysis showed that EX-Se and FA-Se were better indicators for soil Se availability in organic material amendment soils. The Marquardt-Levenberg Model well described the dynamic kinetics of FA-Se content after Se-enriched organic material amendment in soil mainly because of the mineralization of organic carbon and organo-selenium. The utilization of Se in P + Se treatment was significantly higher than those in WS + Se treatment because of the different mineralization rates and the amount of FA-Se in soil. Se-enriched organic materials amendment can not only increase the availability of selenium in soil but also avoid the waste of valuable Se source. Copyright © 2018 Elsevier Ltd. All rights reserved.

Selenium species-dependent toxicity, bioavailability and metabolic transformations in Caenorhabditis elegans.

PubMed

Rohn, Isabelle; Marschall, Talke Anu; Kroepfl, Nina; Jensen, Kenneth Bendix; Aschner, Michael; Tuck, Simon; Kuehnelt, Doris; Schwerdtle, Tanja; Bornhorst, Julia

2018-05-17

The essential micronutrient selenium (Se) is required for various systemic functions, but its beneficial range is narrow and overexposure may result in adverse health effects. Additionally, the chemical form of the ingested selenium contributes crucially to its health effects. While small Se species play a major role in Se metabolism, their toxicological effects, bioavailability and metabolic transformations following elevated uptake are poorly understood. Utilizing the tractable invertebrate Caenorhabditis elegans allowed for an alternative approach to study species-specific characteristics of organic and inorganic Se forms in vivo, revealing remarkable species-dependent differences in the toxicity and bioavailability of selenite, selenomethionine (SeMet) and Se-methylselenocysteine (MeSeCys). An inverse relationship was found between toxicity and bioavailability of the Se species, with the organic species displaying a higher bioavailability than the inorganic form, yet being less toxic. Quantitative Se speciation analysis with HPLC/mass spectrometry revealed a partial metabolism of SeMet and MeSeCys. In SeMet exposed worms, identified metabolites were Se-adenosylselenomethionine (AdoSeMet) and Se-adenosylselenohomocysteine (AdoSeHcy), while worms exposed to MeSeCys produced Se-methylselenoglutathione (MeSeGSH) and γ-glutamyl-MeSeCys (γ-Glu-MeSeCys). Moreover, the possible role of the sole selenoprotein in the nematode, thioredoxin reductase-1 (TrxR-1), was studied comparing wildtype and trxr-1 deletion mutants. Although a lower basal Se level was detected in trxr-1 mutants, Se toxicity and bioavailability following acute exposure was indistinguishable from wildtype worms. Altogether, the current study demonstrates the suitability of C. elegans as a model for Se species dependent toxicity and metabolism, while further research is needed to elucidate TrxR-1 function in the nematode.

Supplementation of organic and inorganic selenium to diets using grains grown in various regions of the United States with differing natural Se concentrations and fed to grower-finisher swine.

PubMed

Mahan, D C; Azain, M; Crenshaw, T D; Cromwell, G L; Dove, C R; Kim, S W; Lindemann, M D; Miller, P S; Pettigrew, J E; Stein, H H; van Heugten, E

2014-11-01

Grains grown in various regions of the United States vary in their innate or natural Se contents. A regional study evaluated the effects of adding inorganic Se (sodium selenite) or organic Se (Se yeast) to diets with differing innate Se contents. A 2 × 2 + 1 factorial experiment evaluating 2 Se sources (organic or inorganic) at 2 Se levels (0.15 or 0.30 mg/kg) in 18 total replicates (n = 360 total pigs). A basal diet was fed without supplemental Se and served as the negative (basal) control. The study was conducted as a randomized complete block design in 9 states (Georgia, Illinois, Kentucky, Nebraska, North Carolina, Ohio, South Dakota, Texas, and Wisconsin) with each station conducting 2 replicates. Pigs were fed from 25 to approximately 115 kg BW. Similar dietary formulations were used at each station, incorporating a common source of trace mineral and Se premixes. Three pigs per treatment in 16 replicates (n = 240) were bled at 55, 85, and 115 kg BW and serum Se and glutathione peroxidase (GSH-Px) activities were determined. Three pigs (n = 260) from each treatment pen were killed at 115 kg BW and issues (liver, loin, and hair) were analyzed for Se. The corn Se content from the various states ranged from 0.026 to 0.283 mg Se/kg while the soybean meal Se content ranged from 0.086 to 0.798 mg Se/kg. Tissue and serum Se concentrations were greater (P < 0.01) when supplemental organic Se was fed, whereas serum GSH-Px was greater (P < 0.01) as Se level increased. There were linear increases (P < 0.01) in loin and quadratic increases (P < 0.01) in liver and hair Se concentrations as dietary Se level increased within each state. There was a source × level interaction (P < 0.01) for each tissue resulting in a greater increase when organic Se was fed. Serum Se and GSH-Px activity increased (P < 0.01) when both Se sources were fed and plateaued at each state at 0.15 mg Se/kg. There was a high and significant correlation between each tissue Se, serum Se, and GSH-Px activity to dietary Se level indicating that those states having greater grain natural Se contents also had greater tissue Se concentrations. These results indicate that a large difference in corn and soybean meal Se concentrations exists between states, that the addition of organic or inorganic Se to these grains increased tissue and serum Se in each state, and that organic Se was incorporated at greater concentrations in the loin, liver, and hair tissues of grower-finisher pigs than inorganic Se.

Fractionation of selenium isotopes during bacterial respiratory reduction of selenium oxyanions

USGS Publications Warehouse

Herbel, M.J.; Johnson, T.M.; Oremland, R.S.; Bullen, T.D.

2000-01-01

Reduction of selenium oxyanions by microorganisms is an important process in the biogeochemical cycling of selenium. Numerous bacteria can reduce Se oxyanions, which are used as electron acceptors during the oxidation of organic matter in anoxic environments. In this study, we used a double spike (82Se and 74Se) thermal ionization mass spectrometry technique to quantify the isotopic fractionation achieved by three different species of anaerobic bacteria capable of accomplishing growth by respiratory reduction of selenate [SeO42- or Se(VI)] or selenite [SeO32- or Se(IV)] to Se(IV) or elemental selenium [Se(0)] coupled with the oxidation of lactate. Isotopic discrimination in these closed system experiments was evaluated by Rayleigh fractionation equations and numerical models. Growing cultures of Bacillus selenitireducens, a haloalkaliphile capable of growth using Se(IV) as an electron acceptor, induced a 80Se/76Se fractionation of -8.0 ?? 0.4??? (instantaneous ?? value) during reduction of Se(IV) to Se(0). With Bacillus arsenicoselenatis, a haloalkaliphile capable of growth using Se(VI) as an electron acceptor, fractionations of -5.0 ?? 0.5??? and -6.0 ?? 1.0??? were observed for reduction of Se(VI) to Se(IV) and reduction of Se(IV) to Se(0), respectively. In growing cultures of Sulfurospirillum barnesii, a freshwater species capable of growth using Se(VI), fractionation was small initially, but near the end of the log growth phase, it increased to -4.0 ?? 1.0??? and -8.4 ?? 0.4??? for reduction of Se(VI) to Se(IV) and reduction of Se(IV) to Se(O), respectively. Washed cell suspensions of S. barnesii induced fractionations of -1.1 ?? 0.4??? during Se(VI) reduction, and -9.1 ?? 0.5% for Se(IV) reduction, with some evidence for smaller values (e.g., -1.7???) in the earliest-formed Se(0) results. These results demonstrate that dissimilatory reduction of selenate or selenite induces significant isotopic fractionation, and suggest that significant Se isotope ratio variation will be found in nature. Copyright (C) 2000 Elsevier Science Ltd.

Assessment of the anticancer compounds Se-methylselenocysteine and glucosinolates in Se-biofortified broccoli (Brassica oleracea L. var. italica) sprouts and florets.

PubMed

Ávila, Fabricio William; Faquin, Valdemar; Yang, Yong; Ramos, Silvio Junio; Guilherme, Luiz Roberto G; Thannhauser, Theodore W; Li, Li

2013-07-03

Broccoli (Brassica oleracea L. var. italica) is a rich source of chemopreventive compounds. Here, we evaluated and compared the effect of selenium (Se) treatment on the accumulation of anticancer compounds Se-methylselenocysteine (SeMSCys) and glucosinolates in broccoli sprouts and florets. Total Se and SeMSCys content in sprouts increased concomitantly with increasing Se doses. Selenate was superior to selenite in inducing total Se accumulation, but selenite is equally effective as selenate in promoting SeMSCys synthesis in sprouts. Increasing sulfur doses reduced total Se and SeMSCys content in sprouts treated with selenate, but not in those with selenite. Examination of five broccoli cultivars reveals that sprouts generally have better fractional ability than florets to convert inorganic Se into SeMSCys. Distinctive glucosinolate profiles between sprouts and florets were observed, and sprouts contained approximately 6-fold more glucoraphanin than florets. In contrast to florets, glucosinolate content was not affected by Se treatment in sprouts. Thus, Se-enriched broccoli sprouts are excellent for simultaneous accumulation of chemopreventive compounds SeMSCys and glucoraphanin.

CDPP Tools in the IMPEx infrastructure

NASA Astrophysics Data System (ADS)

Gangloff, Michel; Génot, Vincent; Bourrel, Nataliya; Hess, Sébastien; Khodachenko, Maxim; Modolo, Ronan; Kallio, Esa; Alexeev, Igor; Al-Ubaidi, Tarek; Cecconi, Baptiste; André, Nicolas; Budnik, Elena; Bouchemit, Myriam; Dufourg, Nicolas; Beigbeder, Laurent

2014-05-01

The CDPP (Centre de Données de la Physique des Plasmas, http://cdpp.eu/), the French data center for plasma physics, is engaged for more than a decade in the archiving and dissemination of plasma data products from space missions and ground observatories. Besides these activities, the CDPP developed services like AMDA (http://amda.cdpp.eu/) which enables in depth analysis of large amount of data through dedicated functionalities such as: visualization, conditional search, cataloguing, and 3DView (http://3dview.cdpp.eu/) which provides immersive visualisations in planetary environments and is further developed to include simulation and observational data. Both tools implement the IMPEx protocol (http://impexfp7.oeaw.ac.at/) to give access to outputs of simulation runs and models in planetary sciences from several providers like LATMOS, FMI , SINP; prototypes have also been built to access some UCLA and CCMC simulations. These tools and their interaction will be presented together with the IMPEx simulation data model (http://impex.latmos.ipsl.fr/tools/DataModel.htm) used for the interface to model databases.

Selenium accumulation in plants--phytotechnological applications and ecological implications.

PubMed

Valdez Barillas, José Rodolfo; Quinn, Colin F; Pilon-Smits, Elizabeth A H

2011-01-01

Selenium (Se) is an essential trace element for many organisms including humans, yet toxic at higher levels. Both Se deficiency and toxicity are problems worldwide. Since plants readily accumulate and volatilize Se, they may be used both as a source of dietary Se and for removing excess Se from the environment. Plant species differ in their capacity to metabolize and accumulate Se, from non-Se accumulators (< 100 mg Se/kg DW), to Se-accumulators (100-1000 mg Se/kg DW) to Se hyperaccumulators (> 1,000 mg Se/kg DW). Here we review plant mechanisms of Se metabolism in these various plant types. We also summarize results from genetic engineering that have led to enhanced plant Se accumulation, volatilization, and/or tolerance, including field studies. Before using Se-accumulating plants at a large scale we need to evaluate the ecological implications. Research so far indicates that plant Se accumulation significantly affects the plant's ecological interactions below and above ground. Selenium canprotect plants from fungal pathogens and from a variety of invertebrate and vertebrate herbivores, due to both deterrence and toxicity. However, specialist (Se-tolerant herbivores), detritivores and endophytes appear to utilize Se hyperaccumulator plants as a resource. These findings are relevant for managing phytoremediation of Se and similar elements.

Characterization of a selenium-tolerant rhizosphere strain from a novel Se-hyperaccumulating plant Cardamine hupingshanesis.

PubMed

Tong, Xinzhao; Yuan, Linxi; Luo, Lei; Yin, Xuebin

2014-01-01

A novel selenium- (Se-) hyperaccumulating plant, Cardamine hupingshanesis, accumulating Se as a form of SeCys2, was discovered in Enshi, Hubei, China, which could not be explained by present selenocysteine methyltransferase (SMT) theory. However, it is interesting to investigate if rhizosphere bacteria play some roles during SeCys2 accumulation. Here, one Se-tolerant rhizosphere strain, Microbacterium oxydans, was isolated from C. hupingshanesis. Phylogenetic analysis and 16S rRNA gene sequences determined the strain as a kind of Gram positive bacillus and belonged to the family Brevibacterium frigoritolerans. Furthermore, Se tolerance test indicated the strain could grow in extreme high Se level of 15.0 mg Se L(-1). When exposed to 1.5 mg Se L(-1), SeCys2 was the predominant Se species in the bacteria, consistent with the Se species in C. hupingshanesis. This coincidence might reveal that this strain played some positive effect in SeCys2 accumulation of C. hupingshanesis. Moreover, when exposed to 1.5 mg Se L(-1) or 15.0 mg Se L(-1), As absorption diminished in the logarithmic phase. In contrast, As absorption increased when exposed to 7.5 mg Se L(-1), indicating As metabolism processes could be affected by Se on this strain. The present study provided a sight on the role of rhizosphere bacteria during Se accumulation for Se-hyperaccumulating plant.

Protective Effects of Cannabidiol against Seizures and Neuronal Death in a Rat Model of Mesial Temporal Lobe Epilepsy

PubMed Central

Do Val-da Silva, Raquel A.; Peixoto-Santos, Jose E.; Kandratavicius, Ludmyla; De Ross, Jana B.; Esteves, Ingrid; De Martinis, Bruno S.; Alves, Marcela N. R.; Scandiuzzi, Renata C.; Hallak, Jaime E. C.; Zuardi, Antonio W.; Crippa, Jose A.; Leite, Joao P.

2017-01-01

The present study reports the behavioral, electrophysiological, and neuropathological effects of cannabidiol (CBD), a major non-psychotropic constituent of Cannabis sativa, in the intrahippocampal pilocarpine-induced status epilepticus (SE) rat model. CBD was administered before pilocarpine-induced SE (group SE+CBDp) or before and after SE (group SE+CBDt), and compared to rats submitted only to SE (SE group), CBD, or vehicle (VH group). Groups were evaluated during SE (behavioral and electrophysiological analysis), as well as at days one and three post-SE (exploratory activity, electrophysiological analysis, neuron density, and neuron degeneration). Compared to SE group, SE+CBD groups (SE+CBDp and SE+CBDt) had increased SE latency, diminished SE severity, increased contralateral afterdischarge latency and decreased relative powers in delta (0.5–4 Hz) and theta (4–10 Hz) bands. Only SE+CBDp had increased vertical exploratory activity 1-day post SE and decreased contralateral relative power in delta 3 days after SE, when compared to SE group. SE+CBD groups also showed decreased neurodegeneration in the hilus and CA3, and higher neuron density in granule cell layer, hilus, CA3, and CA1, when compared to SE group. Our findings demonstrate anticonvulsant and neuroprotective effects of CBD preventive treatment in the intrahippocampal pilocarpine epilepsy model, either as single or multiple administrations, reinforcing the potential role of CBD in the treatment of epileptic disorders. PMID:28367124

Endogenous molecules released by haemocytes receiving Sargassum oligocystum extract lead to downstream activation and synergize innate immunity in white shrimp Litopenaeus vannamei.

PubMed

Shi, Yin-Ze; Chen, Jiann-Chu; Chen, Yu-Yuan; Kuo, Yi-Hsuan; Li, Hui-Fang

2018-05-01

White shrimp Litopenaeus vannamei haemocytes receiving immunostimulating Sargassum oligocystum extract (SE) caused necrosis in haemocyte cells, which released endogenous EM-SE molecules. This study examined the immune response of white shrimp L. vannamei receiving SE and EM-SE in vitro and in vivo. Shrimp haemocytes receiving SE exhibited degranulation, changes in cell size and cell viability, necrosis and a release of EM-SE. Shrimp haemocytes receiving SE, EM-SE, and the SE + EM-SE mixture (SE + EM-SE) increased their phenoloxidase (PO) activity which was significantly higher in shrimp haemocytes receiving the SE + EM-SE mixture. Furthermore, shrimp haemocytes receiving EM-SE showed degranulation and changes in cell size and cell viability. Shrimp receiving SE, EM-SE, and SE + EM-SE all increased their immune parameters, phagocytic activity, clearance efficiency and resistance to Vibrio alginolyticus, being significantly higher in shrimp receiving SE + EM-SE. Meanwhile, the recombinant lipopolysaccharide- and β-1,3-glucan binding protein of L. vannamei (rLvLGBP) was bound to SE, EM-SE, and SE + EM-SE. We conclude that in shrimp haemocytes receiving a non-self molecule, SE in dying cells released EM-SE which led to downstream activation and synergization of the immune response. This study demonstrated that the innate immunity of shrimp was elicited and enhanced by a mixture of endogenous molecules and exogenous substances (or immunostimulants). Copyright © 2018 Elsevier Ltd. All rights reserved.

Efficacy of selenium from hydroponically produced selenium-enriched kale sprout (Brassica oleracea var. alboglabra L.) in broilers.

PubMed

Chantiratikul, Anut; Pakmaruek, Pornpan; Chinrasri, Orawan; Aengwanich, Worapol; Chookhampaeng, Sumalee; Maneetong, Sarunya; Chantiratikul, Piyanete

2015-05-01

An experiment was conducted to determine the efficacy of Se from hydroponically produced Se-enriched kale sprout (HPSeKS) on performance, carcass characteristics, tissue Se concentration, and physiological responses of broilers in comparison to that of Se from Se-enriched yeast and sodium selenite. Three hundred and sixty male broilers, 10 days of age, were assigned to 6 groups, 4 replicates of 15 broilers each, according to the completely randomized design. The dietary treatments were the following: T1: control diet; T2: control diet plus 0.3 mg Se/kg from sodium selenite; T3: control diet plus 0.3 mg Se/kg from Se-enriched yeast; and T4, T5, and T6: control diet plus 0.3, 1.0, and 2.0 mg Se/kg from HPSeKS, respectively. The results found that dietary Se supplementation did not (p > 0.05) alter performance and carcass characteristics of broilers. Se supplementation increased (p < 0.05) Se concentrations in the liver and kidney of broilers. Heart tissue Se concentration of broilers fed Se from sodium selenite was lower (p < 0.05) than that of broilers fed Se from HPSeKS and Se-enriched yeast. Selenium from HPSeKS increased higher (p < 0.05) GSH-Px activity when compared to Se from sodium selenite and Se-enriched yeast. The results indicated that the efficacy of Se from HPSeKS was comparable in increasing tissue Se concentration, but higher in improving GSH-Px activity in Rbc when compared to those of Se from Se-enriched yeast.

Defense AT and L. Volume 44, Number 3

DTIC Science & Technology

2015-06-01

CommunityBrowser.aspx?id=527436 Product Support Key References https://acc.dau.mil/productsupport CLL 011 Performance-Based Life Cycle Product Support (PBL...http://icatalog.dau.mil/onlinecatalog/courses.aspx?crs_id=269 CLL 031 PBL Contracting Strategies http://icatalog.dau.mil/onlinecatalog/courses.aspx...CommunityBrowser.aspx?id=527436 Product Support Key References https://acc.dau.mil/productsupport CLL 011 Performance-Based Life Cycle Product Support (PBL) http

78 FR 8154 - Request for Comment: Input on Recommendations from the Council of Councils Working Group on Use...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-05

... Research on January 22, 2013. The report is posted on the NIH Web site at http://dpcpsi.nih.gov/council..., March 23, 2013, via the comment database at http://grants.nih.gov/grants/rfi/rfi.cfm?ID=31 . In the interim, NIH will continue to apply its policy on Research Involving Chimpanzees (see NOT-OD-12-025; http...

Shaping Strategic Defense: The Air Force Nuclear Mission

DTIC Science & Technology

2009-01-01

Strike Command. Washington DC: Department of the Air Force. Kall , Rob. June 20, 2008. “Pentagon: Over 1000 Nuclear Weapons Parts Missing?” http...www.huffingtonpost.com/rob- kall /pentagon-over-1000-nuclea_b_108225.html (accessed December 16, 2008). Rolfsen, B. November 6, 2007. http...16, 2008). 6 Schlesinger. 7 Kall , Rob. June 20, 2008. “Pentagon: Over 1000 Nuclear Weapons Parts Missing?” http://www.huffingtonpost.com/rob- kall

75 FR 70921 - Simon Property Group, Inc.; Analysis of Proposed Agreement Containing Consent Orders To Aid...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-19

... site, at http:[sol][sol]www.ftc.gov[sol]os[sol]publiccomments.shtm. Because comments will be made.../simonproperty . If this Notice appears at http:[sol][sol]www.regulations.gov[sol]search[sol]index.jsp, you may... regulations.gov forwards to it. You may also visit the FTC Web site at http:[sol][sol]www.ftc.gov[sol] to read...

Alternatives to Center of Gravity Analysis

DTIC Science & Technology

2013-04-04

Field Manual 3-0 Operations (FM 3-0), A-1-A-4, and Mission & Values, McDonalds. http://www.aboutmcdonalds.com/ mcd /our_ company...Porter, Competitive Strategy, 1980. “Mission & Values,” McDonalds. http://www.aboutmcdonalds.com/ mcd /our_ company/mission_and_values.html...Thailand and Cambodia reach deal on temple border,”BBC.com, December 11, 2011. http://www.bbc.co.uk/news/world- asia -pacific-16294309. “The

A Deafening Silence: Hizballah After the American Invasion of Iraq

DTIC Science & Technology

2007-01-01

see Saad-Ghorayeb, 168-186. 19 Verse 5:82, as quoted in Saad-Ghorayeb, 175. 20 Naim Kassem , “Hizbullah’s Future.” Available online at http...Lebanon-Israel Border.” Working Paper #368. Washington: Washington Institute for Near East Policy (04 Mar. 2002): online edition. Kassem , Naim...http://www.naimkassem.org (Website of Naim Kassem , Deputy Secretary- General of Hizballah) http://www.nasrollah.com (Website of Hassan

33 CFR 154.106 - Incorporation by reference: Where can I get a copy of the publications incorporated by reference...

Code of Federal Regulations, 2010 CFR

2010-07-01

... NW., Washington, DC 20037, 202-682-8000, http://www.api.org/: (1) API Standard 2000, Venting... Institute (ANSI), 11 West 42nd Street, New York, NY 10036, 202-293-8020, http://www.ansi.org: (1) ANSI B16.5... International, 100 Barr Harbor Drive, West Conshohocken, PA 19428-2959, 610-832-9585, http://www.astm.org/: (1...

Present and Future of the United States-Bolivia Relations

DTIC Science & Technology

2009-12-11

Programa de Gobierno-MAS-IPSP,” Archivo Chile , http://www.archivochile.com/Portada/bol_elecciones05/bolelecciones0009.pdf (accessed May 2, 2009...accessed November 9, 2009). Movimiento al Socialismo. “ Programa de Gobierno-MAS-IPSP.” Archivo Chile . http://www.archivochile.com/Portada/bol_elecciones05...partidos en Bolivia,” Futuros Revista Trimestral Latinoamericana y Caribeña de Desarrollo Sustentable, http://www.revistafuturos.info/ futuros_9

Democratic Security and Defense Policy: A Successful Counterinsurgency Model

DTIC Science & Technology

2012-06-08

Nueva Colombia, “ Programa Agrario de los Guerrilleros de las FARC,” Mbolivariano.blogspot.com, http://mbolivariano.blogspot. com/2007/12/ programa ...Conferencias de FARC.” Archivo Chile . http://www. Archivochile. Com/america_latina/doc_paises_al/co/farc/ al_farc0003. Pdf (accessed 24 September 2011... Programa Agrario de los Guerrilleros de las FARC.” Mbolivariano.blogspot.com, http://mbolivariano.blogspot. com/2007/12/ programa -agrario- de -los

Prospects for automated diagnosis of verbal autopsies.

PubMed

Garenne, Michel

2014-02-04

Verbal autopsy is a method for assessing probable causes of death from lay reporting of signs, symptoms and circumstances by family members or caregivers of a deceased person. Several methods of automated diagnoses of causes of death from standardized verbal autopsy questionnaires have been developed recently (Inter-VA, Tariff, Random Forest and King-Lu). Their performances have been assessed in a series of papers in BMC Medicine. Overall, and despite high specificity, the current strategies of automated computer diagnoses lead to relatively low sensitivity and positive predictive values, even for causes which are expected to be easily assessed by interview. Some methods have even abnormally low sensitivity for selected diseases of public health importance and could probably be improved. Ways to improve the current strategies are proposed: more detailed questionnaires; using more information on disease duration; stratifying for large groups of causes of death by age, sex and main category; using clusters of signs and symptoms rather than quantitative scores or ranking; separating indeterminate causes; imputing unknown cause with appropriate methods. Please see related articles: http://www.biomedcentral.com/1741-7015/12/5; http://www.biomedcentral.com/1741-7015/12/19; http://www.biomedcentral.com/1741-7015/12/20; http://www.biomedcentral.com/1741-7015/12/21; http://www.biomedcentral.com/1741-7015/12/22; http://www.biomedcentral.com/1741-7015/12/23.

Productivity and selenium concentrations in egg and tissue of laying quails fed selenium from hydroponically produced selenium-enriched kale sprout (Brassica oleracea var. alboglabra L.).

PubMed

Chinrasri, Orawan; Chantiratikul, Piyanete; Maneetong, Sarunya; Chookhampaeng, Sumalee; Chantiratikul, Anut

2013-12-01

This study aimed to determine the effectiveness of Se from hydroponically produced Se-enriched kale sprout (HPSeKS) on productive performance, egg quality, and Se concentrations in egg and tissue of laying quails. Two-hundred quails, 63 days of age, were divided into four groups. Each group consisted of five replicates and each replicate had ten birds, according to a completely randomized design. The experiment lasted for 6 weeks. The dietary treatments were T1 (control diet), T2 (control diet plus 0.2 mg Se/kg from sodium selenite), T3 (control diet plus 0.2 mg Se/kg from Se-enriched yeast), T4 (control diet plus 0.2 mg Se/kg from HPSeKS). The findings revealed that productive performance and egg quality of quails were not altered (p > 0.05) by Se sources. Whole egg Se concentrations of quails fed Se from HPSeKS and Se-enriched yeast were higher (p < 0.05) than that of quails fed the control diet. Breast muscle Se concentrations in quails fed Se from HPSeKS were higher (p < 0.05) than that of quails fed Se from sodium selenite and Se-enriched yeast. Heart tissue Se concentrations of quails fed Se from Se-enriched yeast and HPSeKS were similar (p > 0.05), but higher (p < 0.05) than that of quails fed Se from sodium selenite. The results reveal that Se from HPSeKS did not change the performance and egg quality of quails. The effectiveness of Se from HPSeKS was comparable to that of Se-enriched yeast, which was higher than that of Se from sodium selenite.

Synthesis, crystal structure, optical, and electronic study of the new ternary thorium selenide Ba{sub 3}ThSe{sub 3}(Se{sub 2}){sub 2}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prakash, Jai; Mesbah, Adel; ICSM, UMR 5257 CEA/CNRS/UM2/ENSCM, Site de Marcoule-Bât. 426, BP 17171, 30207 Bagnols-sur-Cèze cedex

2015-11-15

The compound Ba{sub 3}ThSe{sub 3}(Se{sub 2}){sub 2} has been synthesized by solid-state methods at 1173 K. Its crystal structure features one-dimensional chains of {sup 1}{sub ∞}[Th(Se){sub 3}(Se{sub 2}){sub 2}{sup 6−}] separated by Ba{sup 2+} cations. Each Th atom in these chains is coordinated to two Se–Se single-bonded pairs and four Se atoms to give rise to a pseudooctahedral geometry around Th. The Th–Se distances are consistent with Th{sup 4+} and hence charge balance of Ba{sub 3}ThSe{sub 3}(Se{sub 2}){sub 2} is achieved as 3×Ba{sup 2+}, 1×Th{sup 4+}, 3×Se{sup 2−}, and 2×Se{sub 2}{sup 2−}. From optical measurements the band gap of Ba{submore » 3}ThSe{sub 3}(Se{sub 2}){sub 2} is 1.96(2) eV. DFT calculations indicate that the compound is a semiconductor. - Graphical abstract: Local coordination environment of Th atoms in the Ba{sub 3}ThSe{sub 3}(Se{sub 2}){sub 2} structure. - Highlights: • Ba{sub 3}ThSe{sub 3}(Se{sub 2}){sub 2} has been synthesized by solid-state methods at 1173 K. • The structure features chains of {sup 1}{sub ∞}[Th(Se){sub 3}(Se{sub 2}){sub 2}{sup 6−}] separated by Ba{sup 2+} cations. • Ba{sub 3}ThSe{sub 3}(Se{sub 2}){sub 2} is a semiconductor with a band gap of 1.96(2) eV.« less

Effect of feed selenium supplementation on milk selenium distribution and mozzarella quality.

PubMed

Liu, H Y; Zhu, W Z; Lu, B Y; Wei, Z H; Ren, D X

2015-12-01

In the present study, the effect of feed Se supplementation on the Se content of raw milk and mozzarella cheese as well as the effect on cheese quality and functionality were determined. The Se milk was produced by supplying dairy cow feed with Se yeast (0.3mg of Se/kg of dry matter), resulting in a Se concentration in milk of 35.81μg/L. The fat, casein, and whey protein of Se milk were separated by ultracentrifugation, and the Se content was determined by atomic absorption spectroscopy. The Se distribution in different milk fractions of fat, casein, and whey protein were 9.82, 45.56, and 44.62%, respectively. The Se mozzarella cheese was made by Se milk, and the composition and texture of Se cheese did not significantly differ from that of the control. However, the functional properties (meltability, flowability, and stretchability) of the Se cheese were better after 8 wk of storage. Moreover, the pH and water activity were lower in Se cheese, which decreased the total plate count. The Se content in mozzarella cheese was 4 fold higher than that in milk, and Se was found in the whey, hot water, and brine collected during cheesemaking. Organic and inorganic Se was found in the Se cheese after 8 wk of storage, and most Se peptides detected after storage were Se-Met and Se-Cys. The results of this study show that feed Se supplementation can improve the Se content of milk and cheese without affecting mozzarella cheese quality. Copyright © 2015 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Selenium speciation and partitioning within Burkholderia cepacia biofilms formed on α-Al 2O 3 surfaces

NASA Astrophysics Data System (ADS)

Templeton, Alexis S.; Trainor, Thomas P.; Spormann, Alfred M.; Brown, Gordon E.

2003-10-01

The distribution and speciation of Se within aerobic Burkholderia cepacia biofilms formed on α-Al 2O 3 (1-102) surfaces have been examined using grazing-angle X-ray spectroscopic techniques. We present quantitative information on the partitioning of 10 -6 M to 10 -3 M selenate and selenite between the biofilms and underlying alumina surfaces derived from long-period X-ray standing wave (XSW) data. Changes in the Se partitioning behavior over time are correlated with microbially induced reduction of Se(VI) and Se(IV) to Se(0), as observed from X-ray absorption near edge structure (XANES) spectroscopy. Selenite preferentially binds to the alumina surfaces, particularly at low [Se], and is increasingly partitioned into the biofilms at higher [Se]. When B. cepacia is metabolically active, B. cepacia rapidly reduces a fraction of the SeO 32- to red elemental Se(0). In contrast, selenate is preferentially partitioned into the B. cepacia biofilms at all [Se] tested due to a lower affinity for binding to the alumina surface. Rapid reduction of SeO 42- by B. cepacia to Se(IV) and Se(0) subsequently results in a vertical segregation of Se species at the B. cepacia/α-Al 2O 3 interface. Elemental Se(0) accumulates within the biofilm with Se(VI), whereas Se(IV) intermediates preferentially sorb to the alumina surface. B. cepacia/α-Al 2O 3 samples incubated with SeO 42- and SeO 32- when the bacteria were metabolically active result in a significant reduction in the mobility of Se vs. X-ray treated biofilms. Remobilization experiments show that a large fraction of the insoluble Se(0) produced within the biofilm is retained during exchange with Se-free solutions. In addition, Se(IV) intermediates generated during Se(VI) reduction are preferentially bound to the alumina surface and do not fully desorb. In contrast, Se(VI) is rapidly and extensively remobilized.

Stellar populations in the Carina region. The Galactic plane at l = 291°

NASA Astrophysics Data System (ADS)

Molina-Lera, J. A.; Baume, G.; Gamen, R.; Costa, E.; Carraro, G.

2016-08-01

Context. Previous studies of the Carina region have revealed its complexity and richness as well as a significant number of early-type stars. However, in many cases, these studies only concentrated on the central region (Trumpler 14/16) or were not homogeneous. This latter aspect, in particular, is crucial because very different ages and distances for key clusters have been claimed in recent years. Aims: The aim of this work is to study in detail an area of the Galactic plane in Carina, eastward η Carina. We analyze the properties of different stellar populations and focus on a sample of open clusters and their population of young stellar objects and highly reddened early stars. We also studied the stellar mass distribution in these clusters and the possible scenario of their formation. Finally, we outline the Galactic spiral structure in this direction. Methods: We obtained deep and homogeneous photometric data (UBVIKC) for six young open clusters: NGC 3752, Trumpler 18, NGC 3590, Hogg 10, 11, and 12, located in Carina at l ~ 291°, and their adjacent stellar fields, which we complemented with spectroscopic observations of a few selected targets. We also culled additional information from the literature, which includes stellar spectral classifications and near-infrared photometry from 2MASS. We finally developed a numerical code that allowed us to perform a homogeneous and systematic analysis of the data. Our results provide more reliable estimates of distances, color excesses, masses, and ages of the stellar populations in this direction. Results: We estimate the basic parameters of the studied clusters and find that they identify two overdensities of young stellar populations located at about 1.8 kpc and 2.8 kpc, with EB - V ~ 0.1 - 0.6. We find evidence of pre-main-sequence populations inside them, with an apparent coeval stellar formation in the most conspicuous clusters. We also discuss apparent age and distance gradients in the direction NW-SE. We study the mass distributions of the covered clusters and several others in the region (which we took form the literature). They consistently show a canonical IMF slope (the Salpeter one). We discover and characterise an abnormally reddened massive stellar population, scattered between 6.6 and 11 kpc. Spectroscopic observations of ten stars of this latter population show that all selected targets were massive OB stars. Their location is consistent with the position of the Carina-Sagittarius spiral arm. The catalogue is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/592/A149

76 FR 37296 - Revision of Patent Fees for Fiscal Year 2012

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-27

..., (SE) $110 $230, (SE) $115 $10, (SE) $5. Application (CPA) (on or after 12/8/2004). 1.16(b)(2) Design... Application $380, (SE) $190 $390, (SE) $195 $10, (SE) $5. Filing (CPA) (before 12/8/2004). 1.16(c)(1) Filing...). 1.16(e)(1) Filing of Reissue $330, (SE) $165 $340, (SE) $170 $10, (SE) $5. Patent Application (CPA...

Selenium accumulation by plants

PubMed Central

White, Philip J.

2016-01-01

Background Selenium (Se) is an essential mineral element for animals and humans, which they acquire largely from plants. The Se concentration in edible plants is determined by the Se phytoavailability in soils. Selenium is not an essential element for plants, but excessive Se can be toxic. Thus, soil Se phytoavailability determines the ecology of plants. Most plants cannot grow on seleniferous soils. Most plants that grow on seleniferous soils accumulate <100 mg Se kg–1 dry matter and cannot tolerate greater tissue Se concentrations. However, some plant species have evolved tolerance to Se, and commonly accumulate tissue Se concentrations >100 mg Se kg–1 dry matter. These plants are considered to be Se accumulators. Some species can even accumulate Se concentrations of 1000–15 000 mg Se kg–1 dry matter and are called Se hyperaccumulators. Scope This article provides an overview of Se uptake, translocation and metabolism in plants and highlights the possible genetic basis of differences in these between and within plant species. The review focuses initially on adaptations allowing plants to tolerate large Se concentrations in their tissues and the evolutionary origin of species that hyperaccumulate Se. It then describes the variation in tissue Se concentrations between and within angiosperm species and identifies genes encoding enzymes limiting the rates of incorporation of Se into organic compounds and chromosomal loci that might enable the development of crops with greater Se concentrations in their edible portions. Finally, it discusses transgenic approaches enabling plants to tolerate greater Se concentrations in the rhizosphere and in their tissues. Conclusions The trait of Se hyperaccumulation has evolved several times in separate angiosperm clades. The ability to tolerate large tissue Se concentrations is primarily related to the ability to divert Se away from the accumulation of selenocysteine and selenomethionine, which might be incorporated into non-functional proteins, through the synthesis of less toxic Se metabilites. There is potential to breed or select crops with greater Se concentrations in their edible tissues, which might be used to increase dietary Se intakes of animals and humans. PMID:26718221

Selenium accumulation by plants.

PubMed

White, Philip J

2016-02-01

Selenium (Se) is an essential mineral element for animals and humans, which they acquire largely from plants. The Se concentration in edible plants is determined by the Se phytoavailability in soils. Selenium is not an essential element for plants, but excessive Se can be toxic. Thus, soil Se phytoavailability determines the ecology of plants. Most plants cannot grow on seleniferous soils. Most plants that grow on seleniferous soils accumulate <100 mg Se kg(-1) dry matter and cannot tolerate greater tissue Se concentrations. However, some plant species have evolved tolerance to Se, and commonly accumulate tissue Se concentrations >100 mg Se kg(-1) dry matter. These plants are considered to be Se accumulators. Some species can even accumulate Se concentrations of 1000-15 000 mg Se kg(-1 )dry matter and are called Se hyperaccumulators. This article provides an overview of Se uptake, translocation and metabolism in plants and highlights the possible genetic basis of differences in these between and within plant species. The review focuses initially on adaptations allowing plants to tolerate large Se concentrations in their tissues and the evolutionary origin of species that hyperaccumulate Se. It then describes the variation in tissue Se concentrations between and within angiosperm species and identifies genes encoding enzymes limiting the rates of incorporation of Se into organic compounds and chromosomal loci that might enable the development of crops with greater Se concentrations in their edible portions. Finally, it discusses transgenic approaches enabling plants to tolerate greater Se concentrations in the rhizosphere and in their tissues. The trait of Se hyperaccumulation has evolved several times in separate angiosperm clades. The ability to tolerate large tissue Se concentrations is primarily related to the ability to divert Se away from the accumulation of selenocysteine and selenomethionine, which might be incorporated into non-functional proteins, through the synthesis of less toxic Se metabilites. There is potential to breed or select crops with greater Se concentrations in their edible tissues, which might be used to increase dietary Se intakes of animals and humans. © The Author 2015. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

The new misfit compound (BiSe){sub 1.15}(TiSe{sub 2}){sub 2} and the role of dimensionality in the Cu{sub x}(BiSe){sub 1+δ}(TiSe{sub 2}){sub n} series

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trump, Benjamin A., E-mail: btrump1@jhu.edu; Department of Physics and Astronomy, Institute for Quantum Matter, Johns Hopkins University, Baltimore, MD 21218; Livi, Kenneth J.T.

The synthesis and physical properties of the new misfit compound (BiSe){sub 1.15}(TiSe{sub 2}){sub 2} are reported. Transmission electron microscopy and powder X-ray diffraction show that the structure consists of alternating rock-salt type BiSe layers and hexagonal (TiSe{sub 2}){sub 2} double layers. Resistivity, specific heat, and magnetization measurements show that it has metallic and diamagnetic behaviors. These results are interpreted and discussed in the context of the transition between single-layer (BiSe){sub 1.13}(TiSe{sub 2}), which shows no charge density wave, and infinite-layered (bulk) 1T-TiSe{sub 2}, which undergoes a charge density wave transition at T=202 K. Intercalation with copper, Cu{sub x}(BiSe){sub 1.15}(TiSe{sub 2}){submore » 2}, (0≤x≤0.10) is also reported, but unlike Cu{sub x}TiSe{sub 2}, no superconductivity is observed down to T=0.05 K. Thus, the series Cu{sub x}(BiSe){sub 1+δ}(TiSe{sub 2}){sub n} provides an effective approach to elucidate the impact of dimensionality on charge density wave formation and superconductivity. - Graphical abstract: The newly discovered misfit compound (BiSe){sub 1.15}(TiSe{sub 2}){sub 2} shown in the series (BiSe){sub 1+δ}(TiSe{sub 2}){sub n}. Display Omitted - Highlights: • Reports the structure and properties of the new misfit compound (BiSe){sub 1.15}(TiSe{sub 2}){sub 2}. • The structure consists of a rock salt type BiSe layer and a double (TiSe{sub 2}){sub 2} layer. • The n=1, 2 misfits (BiSe){sub 1+δ}(TiSe{sub 2}){sub n} are found not to exhibit CDW transitions. • Evidence is presented that there is likely a low-lying CDW excited state. • The series Cu{sub x}(BiSe){sub 1+δ}(TiSe{sub 2}){sub 2} does not superconduct, unlike Cu{sub x}TiSe{sub 2}.« less

Comparison of the metabolism of inorganic and organic selenium species between two selenium accumulator plants, garlic and Indian mustard.

PubMed

Ogra, Yasumitsu; Ogihara, Yurie; Anan, Yasumi

2017-01-25

The metabolism of selenomethionine (SeMet) in two major selenium (Se) accumulator plants, garlic and Indian mustard, was compared to that of stable isotope labeled selenate. Indian mustard more efficiently transported Se from roots to leaves than garlic. In addition, Indian mustard accumulated larger amounts of Se than garlic. γ-Glutamyl-Se-methylselenocysteine (γ-GluMeSeCys) and Se-methylselenocysteine (MeSeCys) were the common metabolites of selenate and SeMet in garlic and Indian mustard. Indian mustard had a specific metabolic pathway to selenohomolanthionine (SeHLan) from both inorganic and organic Se species. SeMet was a more effective fertilizer for cultivating Se-enriched plants than selenate in terms of the production of selenoamino acids.

Reverse Monte Carlo simulation of Se{sub 80}Te{sub 20} and Se{sub 80}Te{sub 15}Sb{sub 5} glasses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abdel-Baset, A. M.; Rashad, M.; Moharram, A. H.

2013-12-16

Two-dimensional Monte Carlo of the total pair distribution functions g(r) is determined for Se{sub 80}Te{sub 20} and Se{sub 80}Te{sub 15}Sb{sub 5} alloys, and then it used to assemble the three-dimensional atomic configurations using the reverse Monte Carlo simulation. The partial pair distribution functions g{sub ij}(r) indicate that the basic structure unit in the Se{sub 80}Te{sub 15}Sb{sub 5} glass is di-antimony tri-selenide units connected together through Se-Se and Se-Te chain. The structure of Se{sub 80}Te{sub 20} alloys is a chain of Se-Te and Se-Se in addition to some rings of Se atoms.

[Selenium uptake and transport of rice under different Se-enriched natural soils].

PubMed

Jiang, Chao-qiang; Shen, Jia; Zu, Chao-long

2015-03-01

In this study, a pot experiment was conducted with "Wandao 205" as test materials to investigate Se uptake and translocation in rice under different Se concentrations (0.5, 1.0, and 1.5 mg . kg-1). Results showed that there was no significant change in rice yield when Se concentration in soil was lower than 1.5 mg . kg-1. Significant linear correlations existed between Se concentration in soil and different rice plant tissues. Se concentration in rice plant followed the order of root > straw > grain. Se concentration in different rice grain fractions followed the order of bran > polished rice > hull. The root absorption index of Se was more than 1.86, suggest that the rice could absorpt Se from soil effectively. However, the transport and accumulation of Se in seeds from Se-enriched soil was relatively constant. The Se transport index in seeds was between 0.53 and 0.59. Soil Se concentration within the range of 0.5 to 1.0 mg . kg-1 could produce Se-enriched rice, which might be enough for human requirement of 60-80 µg . d-1 Se. However, polished rice at high-Se treatment (1.5 mg . kg-1) exceeded the maximum standard limit of Se (0.3 mg . kg-1) for cereals in China. These results suggested that we could produce Se-enriched rice under soil Se concentration in the range of 0.5 to 1.0 mg . kg-1 without spraying Se fertilizer, thus reducing the cost and avoiding soil and water pollution caused by exogenous Se.

A selenium-deficient Caco-2 cell model for assessing differential incorporation of chemical or food selenium into glutathione peroxidase.

PubMed

Zeng, Huawei; Botnen, James H; Johnson, Luann K

2008-01-01

Assessing the ability of a selenium (Se) sample to induce cellular glutathione peroxidase (GPx) activity in Se-deficient animals is the most commonly used method to determine Se bioavailability. Our goal is to establish a Se-deficient cell culture model with differential incorporation of Se chemical forms into GPx, which may complement the in vivo studies. In the present study, we developed a Se-deficient Caco-2 cell model with a serum gradual reduction method. It is well recognized that selenomethionine (SeMet) is the major nutritional source of Se; therefore, SeMet, selenite, or methylselenocysteine (SeMSC) was added to cell culture media with different concentrations and treatment time points. We found that selenite and SeMSC induced GPx more rapidly than SeMet. However, SeMet was better retained as it is incorporated into proteins in place of methionine; compared with 8-, 24-, or 48-h treatment, 72-h Se treatment was a more sensitive time point to measure the potential of GPx induction in all tested concentrations. Based on induction of GPx activity, the cellular bioavailability of Se from an extract of selenobroccoli after a simulated gastrointestinal digestion was comparable with that of SeMSC and SeMet. These in vitro data are, for the first time, consistent with previous published data regarding selenite and SeMet bioavailability in animal models and Se chemical speciation studies with broccoli. Thus, Se-deficient Caco-2 cell model with differential incorporation of chemical or food forms of Se into GPx provides a new tool to study the cellular mechanisms of Se bioavailability.

Biomarkers in critically ill patients with systemic inflammatory response syndrome or sepsis supplemented with high-dose selenium.

PubMed

Brodska, Helena; Valenta, Jiri; Malickova, Karin; Kohout, Pavel; Kazda, Antonin; Drabek, Tomas

2015-01-01

Low levels of selenium (Se) and glutathione peroxidase (GSHPx), a key selenoenzyme, were documented in systemic inflammatory response syndrome (SIRS) and sepsis, both associated with high mortality. Se supplementation had mixed effects on outcome. We hypothesized that Se supplementation could have a different impact on biomarkers and 28-day mortality in patients with SIRS vs. sepsis. Adult patients with SIRS or sepsis were randomized to either high-dose (Se+, n = 75) or standard-dose (Se-, n = 75) Se supplementation. Plasma Se, whole blood GSHPx activity, C-reactive protein (CRP), procalcitonin (PCT), prealbumin, albumin and cholesterol levels were measured serially up to day 14. There was no difference in mortality between Se- (24/75) vs. Se+ group (19/75; p = 0.367) or between SIRS and septic patients (8/26 vs. 35/124; p = 0.794). There was a trend to reduced mortality in SIRS patients in the Se+ vs. Se- group (p = 0.084). Plasma Se levels increased in the Se+ group only in patients with sepsis but not in patients with SIRS. Plasma Se levels correlated with GSHPx. In SIRS/Se+ group, Se correlated only with GSHPx. In SIRS/Se- group, Se correlated with cholesterol but not with other biomarkers. In sepsis patients, Se levels correlated with cholesterol, GSHPx and prealbumin. Cholesterol levels were higher in survivors in the Se- group. Se levels correlated with GSHPx activity and other nutritional biomarkers with significant differences between SIRS and sepsis groups. High-dose Se supplementation did not affect mortality but a strong trend to decreased mortality in SIRS patients warrants further studies in this population. Copyright © 2015 Elsevier GmbH. All rights reserved.

Microbial oxidation of elemental selenium in soil slurries and bacterial cultures

USGS Publications Warehouse

Dowdle, P.R.; Oremland, R.S.

1998-01-01

The microbial oxidation of elemental selenium [Se(O)] was studied by employing 75Se(O) as a tracer. Live, oxic soil slurries demonstrated a linear production of mostly Se(IV), with the formation of smaller quantities of Se(VI). Production of both Se(IV) and Se(VI) was inhibited by autoclaving, formalin, antibiotics, azide, and 2,4-dinitrophenol, thereby indicating the involvement of microbes. Oxidation of Se(O) in slurries was enhanced by addition of acetate, glucose, or sulfide, which implied involvement of chemoheterotrophs as well as chemoautotrophic thiobacilli. Cultures of Thiobacillus ASN-1, Leptothrix MnB1, and a heterotrophic soil enrichment all oxidized Se(O) with Se(VI) observed as the major product rather than Se(IV). This indicated that microbial oxidation in soils is partly constrained by the adsorption of Se(IV) onto soil surfaces. Rate constants for unamended soil slurry Se(O) oxidation ranged from 0.0009 to 0.0117 day-1 which were 3-4 orders of magnitude lower than those reported for dissimilatory Se(VI) reduction in organic-rich, anoxic sediments.The microbial oxidation of elemental selenium [Se(0)] was studied by employing 75Se(0) as a tracer. Live, oxic soil slurries demonstrated a linear production of mostly Se(IV), with the formation of smaller quantities of Se(VI). Production of both Se(IV) and Se(VI) was inhibited by autoclaving, formalin, antibiotics, azide, and 2,4-dinitrophenol, thereby indicating the involvement of microbes. Oxidation of Se(O) in slurries was enhanced by addition of acetate, glucose, or sulfide, which implied involvement of chemoheterotrophs as well as chemoautotrophic thiobacilli. Cultures of Thiobacillus ASN-1, Leptothrix MnB1, and a heterotrophic soil enrichment all oxidized Se(O) with Se(VI) observed as the major product rather than Se(IV). This indicated that microbial oxidation in soils is partly constrained by the adsorption of Se(IV) onto soil surfaces. Rate constants for unamended soil slurry Se(O) oxidation ranged from 0.0009 to 0.0117 day-1 which were 3-4 orders of magnitude lower than those reported for dissimilatory Se(VI) reduction in organic-rich, anoxic sediments.

[Effects of sulfur on transformation of selenium in soil and uptake of selenium in rape].

PubMed

Liu, Xin-wei; Duan, Bi-huil; Xia, Quan-jie; Jiao, Wei; Guo, Zai-hua; Hu, Cheng-xiao; Zhao, Zhu-qing

2014-09-01

The high-quality, high-yield rape (Brassica napus L. cv. Xiangnongyou 571) was chosen as the experimental material to undergo seedling stage soil cultivation and solution cultivation. This study was aimed to investigate the effects of sulfur (S) on the fraction and species of amend selenium (Se) in soil by applying S fertilizer, and to reveal the mechanism through which S controls the Se uptake of rape. The results showed that applications of both Se at 5 mg.kg-1 and S at 150 mg.kg-1 could provide some boost to rape growth, however such boost was unremarkable; S application could significantly reduce Se content in shoots and roots by as much as 64. 0% and 39. 1% , respectively; S application could significantly decrease the pH value and increase the organic matter content by as much as 0. 65 units and 1.76 g.kg-1 , respectively; S application could significantly decrease soluble Se and Fe/Mn oxide-bound Se, and significantly increase organic matter-bound Se, however, there was no remarkable effect on exchangeable and residual Se. S could significantly decrease the content of Se(IV) in the soluble Se and significantly increase the content of Se(IV) in the exchangeable Se, with remarkable decrease in Se(VI) content in both fractions, and no remarkable effect on Se(II). S had a profound effect on the uptake of Se by rape seedlings when Se( IV) and Se( VI) were applied. The Se contents in shoot and root of the Se( VI)-treated rape were 7.3 and 3.2 times respectively as high as that of the Se( IV)-treated rape, while with a S rate of 2 mmolL-1, their Se contents were lower than 32.6% and 8.7% of that of the Se(IV)-treated rape. In conclusion, in addition to improving crop growth, appropriate amount of S fertilizer could also reduce soil pH and increase organic content, causing available Se in soil to be Fe/Mn oxide-bound and organic matter-bound, and retarding its transformation to Se( VI), thus reducing Se uptake by rape. This has significant value for regulation of Se content in crops from Se-rich regions, ensuring food quality and safety, benefiting the long-term use of soil Se resources and regional economic development.

Stable selones in glutathione-peroxidase-like catalytic cycle of selenonicotinamide derivative.

PubMed

Prabhu, Parashiva; Singh, Beena G; Noguchi, Masato; Phadnis, Prasad P; Jain, Vimal K; Iwaoka, Michio; Priyadarsini, K Indira

2014-04-21

Selenonicotinamide, 2,2'-diselenobis[3-amidopyridine] (NictSeSeNict) exhibits glutathione-peroxidase (GPx)-like activity, catalyzing the reduction of hydrogen peroxide (H2O2) by glutathione (GSH). Estimated reactivity parameters for the reaction of selenium species, according to the Dalziel kinetic model, towards GSH (ϕGSH) and H2O2 (ϕH2O2), indicated that the rate constant for the reaction of NictSeSeNict with GSH is higher as compared to that with H2O2, indicating that the activity is initiated by reduction. (77)Se NMR spectroscopy, HPLC analysis, mass spectrometry (MS) and absorption spectroscopy were employed to understand the nature of selenium intermediates responsible for the activity. The (77)Se NMR resonance at 525 ppm due to NictSeSeNict disappeared in the presence of GSH with the initial appearance of signals at δ 364 and 600 ppm, assigned to selone (NictC=Se) and selenenyl sulfide (NictSeSG), respectively. Reaction of H2O2 with NictSeSeNict produced a mixture of selenenic acid (NictSeOH) and seleninic acid (NictSeO2H) with (77)Se NMR resonances appearing at 1069 and 1165 ppm, respectively. Addition of three equivalents of GSH to this mixture produced a characteristic (77)Se NMR signal of NictSeSG. HPLC analysis of the product formed by the reaction of NictSeSeNict with GSH confirmed the formation of NictC=Se absorbing at 375 nm. Stopped-flow kinetic studies with global analysis revealed a bimolecular rate constant of 4.8 ± 0.5 × 10(3) M(-1) s(-1) and 1.7 ± 0.6 × 10(2) M(-1) s(-1) for the formation of NictC=Se produced in two consecutive reactions of NictSeSeNict and NictSeSG with GSH, respectively. Similarly the rate constant for the reaction of NictC=Se with H2O2 was estimated to be 18 ± 1.8 M(-1) s(-1). These studies clearly indicated that the GPx activity of NictSeSeNict is initiated by reduction to form NictSeSG and a stable selone, which is responsible for its efficient GPx activity.

Selenium requirements based on muscle and kidney selenoprotein enzyme activity and transcript expression in the turkey poult (Meleagris gallopavo).

PubMed

Taylor, Rachel M; Sunde, Roger A

2017-01-01

The current NRC selenium (Se) requirement for turkeys is 0.2 μg Se/g diet. We previously fed turkey poults a Se-deficient diet (0.005 μg Se/g) supplemented with 10 graded levels of Se (0, 0.025, 0.05, 0.1, 0.2, 0.3, 0.4, 0.5, 0.75, 1.0 μg Se/g as Na2SeO3, 5/treatment) for 4 wk, and found that the minimum dietary Se requirement was 0.3 μg Se/g based on selenoprotein enzyme activity in blood, liver, gizzard and pancreas. Because the turkey is primarily a production animal, we expanded this analysis to kidney, heart, breast and thigh. Se concentrations in Se-deficient poults were 5.0, 9.8, 33, and 15% of levels in poults fed 0.4 μg Se/g in liver, kidney, thigh and breast, respectively. Increasing Se supplementation resulted in hyperbolic response curves for all tissues; breakpoint analysis indicated minimum Se requirements of 0.34-0.36 μg Se/g based on tissue Se levels in liver, kidney and thigh. Similarly, GPX1 activity in muscle tissues and kidney responded hyperbolically to increasing dietary Se, reaching well-defined plateaus with breakpoints at 0.30-0.36 μg Se/g. Minimum Se requirements based on GPX4 activity were 0.30-0.32 μg Se/g for breast and thigh. Selenoprotein transcript expression decreased significantly in Se deficiency for only 2, 3, 5, and 6 mRNA in breast, thigh, heart, and kidney, respectively, out of 24 known avian selenoproteins. Se response curves for regulated selenoprotein transcripts were hyperbolic, and reached well-defined plateaus with breakpoints in a narrow range of 0.08-0.19 μg Se/g. No selenoprotein transcript was altered by supernutritional Se. In summary, these results clearly indicate that the NRC dietary Se requirement should be raised to 0.4 μg Se/g, at least for poults, to meet the nutritional needs of the young turkey. The Se response curve plateaus further show that limits for turkey supplementation with selenite could safely be raised to 0.5 μg Se/g diet.

A grid of MARCS model atmospheres for late-type stars. II. S stars and their properties

NASA Astrophysics Data System (ADS)

Van Eck, Sophie; Neyskens, Pieter; Jorissen, Alain; Plez, Bertrand; Edvardsson, Bengt; Eriksson, Kjell; Gustafsson, Bengt; Jørgensen, Uffe Gråe; Nordlund, Åke

2017-05-01

S-type stars are late-type giants whose atmospheres are enriched in carbon and s-process elements because of either extrinsic pollution by a binary companion or intrinsic nucleosynthesis and dredge-up on the thermally-pulsing asymptotic giant branch. A grid of MARCS model atmospheres has been computed for S stars, covering the range 2700 ≤ Teff(K) ≤ 4000, 0.50 ≤ C/O ≤ 0.99, 0 ≤ log g ≤ 5, [Fe/H] = 0., -0.5 dex, and [s/Fe] = 0, 1, and 2 dex (where the latter quantity refers to the global overabundance of s-process elements). The MARCS models make use of a new ZrO line list. Synthetic spectra computed from these models are used to derive photometric indices in the Johnson and Geneva systems, as well as TiO and ZrO band strengths. A method is proposed to select the model best matching any given S star, a non-trivial operation since the grid contains more than 3500 models covering a five-dimensional parameter space. The method is based on the comparison between observed and synthetic photometric indices and spectral band strengths, and has been applied on a vast subsample of the Henize sample of S stars. Our results confirm the old claim by Piccirillo (1980, MNRAS, 190, 441) that ZrO bands in warm S stars (Teff>3200 K) are not caused by the C/O ratio being close to unity, as traditionally believed, but rather by some Zr overabundance. The TiO and ZrO band strengths, combined with V-K and J-K photometric indices, are used to select Teff, C/O, [Fe/H] and [s/Fe]. The Geneva U-B1 and B2-V1 indices (or any equivalent) are good at selecting the gravity. The defining spectral features of dwarf S stars are outlined, but none is found among the Henize S stars. More generally, it is found that, at Teff = 3200 K, a change of C/O from 0.5 to 0.99 has a strong impact on V-K (2 mag). Conversely, a range of 2 mag in V-K corresponds to a 200 K shift along the (Teff, V-K) relationship (for a fixed C/O value). Hence, the use of a (Teff, V-K) calibration established for M stars will yield large errors for S stars, so that a specific calibration must be used, as provided in the present paper. Using the atmospheric parameters derived by our method for the sample of Henize S stars, we show that the extrinsic-intrinsic dichotomy among S stars reveals itself very clearly as a bimodal distribution in the effective temperatures. Moreover, the increase of s-process element abundances with increasing C/O ratios and decreasing temperatures is apparent among intrinsic stars, confirming theoretical expectations. Based on observations carried out at the European Southern Observatory (ESO, La Silla, Chile; program 58.E-0942), on the Swiss 70 cm telescope (La Silla, Chile) and on the Mercator telescope (La Palma, Spain).The MARCS S star model atmospheres will be archived on the MARCS website: http://marcs.astro.uu.seFull Tables 2 and 3 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/601/A10

Ocean data management in OMP Data Service

NASA Astrophysics Data System (ADS)

Fleury, Laurence; André, François; Belmahfoud, Nizar; Boichard, Jean-Luc; Brissebrat, Guillaume; Ferré, Hélène; Mière, Arnaud

2014-05-01

The Observatoire Midi-Pyrénées Data Service (SEDOO) is a development team, dedicated to environmental data management and dissemination application set up, in the framework of intensive field campaigns and long term observation networks. SEDOO developped some applications dealing with ocean data only, but also generic databases that enable to store and distribute multidisciplinary datasets. SEDOO is in charge of the in situ data management and the data portal for international and multidisciplinary programmes as large as African Monsoon Multidisciplinary Analyses (AMMA) and Mediterranean Integrated STudies at Regional And Local Scales (MISTRALS). The AMMA and MISTRALS databases are distributed and the data portals enable to access datasets managed by other data centres (IPSL, CORIOLIS...) through interoperability protocols (OPeNDAP, xml requests...). AMMA and MISTRALS metadata (data description) are standardized and comply with international standards (ISO 19115-19139; INSPIRE European Directive; Global Change Master Directory Thesaurus). Most of the AMMA and MISTRALS in situ ocean data sets are homogenized and inserted in a relational database, in order to enable accurate data selection and download of different data sets in a shared format. Data selection criteria are location, period, physical property name, physical property range... The data extraction procedure include format output selection among CSV, NetCDF, Nasa Ames... The AMMA database - http://database.amma-international.org/ - contains field campaign observations in the Guinea Gulf (EGEE 2005-2007) and Atlantic Tropical Ocean (AEROSE-II 2006...), as well as long term monitoring data (PIRATA, ARGO...). Operational analysis (MERCATOR) and satellite products (TMI, SSMI...) are managed by IPSL data centre and can be accessed too. They have been projected over regular latitude-longitude grids and converted into the NetCDF format. The MISTRALS data portal - http://mistrals.sedoo.fr/ - enables to access ocean datasets produced by the contributing programmes: Hydrological cycle in the Mediterranean eXperiment (HyMeX), Chemistry-Aerosol Mediterranean eXperiment (ChArMEx), Marine Mediterranean eXperiment (MERMeX)... The programmes include many field campaigns from 2011 to 2015, collecting general and specific properties. Long term monitoring networks, like Mediterranean Ocean Observing System on Environment (MOOSE) or Mediterranean Eurocentre for Underwater Sciences and Technologies (MEUST-SE), contribute to the MISTRALS data portal as well. Relevant model outputs and satellite products managed by external data centres (IPSL, ENEA...) can be accessed too. SEDOO manages the SSS (Sea Surface Salinity) national observation service data: http://sss.sedoo.fr/. SSS aims at collecting, validating, archiving and distributing in situ SSS measurements derived from Voluntary Observing Ship programs. The SSS data user interface enables to built multicriteria data request and download relevant datasets. SEDOO contributes to the SOLWARA project that aims at understanding the oceanic circulation in the Coral Sea and the Solomon Sea and their role in both the climate system and the oceanic chemistry. The research programme include in situ measurements, numerical modelling and compiled analyses of past data. The website http://thredds.sedoo.fr/solwara/ enables to access, visualize and download Solwara gridded data and model simulations, using Thredds associated services (OPEnDAP, NCSS and WMS). In order to improve the application user-friendliness, SSS and SOLWARA web interfaces are JEE applications build with GWT Framework, and share many modules.

Continued selenium biofortification of carrots and broccoli grown in soils once amended with Se-enriched S. pinnata

USDA-ARS?s Scientific Manuscript database

Selenium (Se) biofortification has been practiced in Se-deficient regions throughout the world primarily by adding inorganic sources of Se to the soil. Adding organic sources of Se could be useful as an alternative Se amendment for the production of Se-biofortified food crops needed in Se-deficient ...

Mission Accomplishment through Outsourcing

DTIC Science & Technology

2006-02-07

salary only and does not include associated benefits. According to the U.S. 7 Chamber of Commerce , employee benefit costs represent 37.6 percent of...articles/ glossary.html#o. 10 Office of Personnel Management, U.S. Government, http://www.opm.gov/oca/06tables/html/dcb.asp. 11 U.S. Chamber of Commerce , http...employee% 20turnover. U.S. Chamber of Commerce . http://www.uschamber.com/press/ releases/2005/january//05-13.htm. USGA. “Employee Turnover

Characterization and Fate of Gun and Rocket Propellant Residues on Testing and Training Ranges

DTIC Science & Technology

2008-01-01

ext/reg_e.html. 36. United States Environmental Protection Agency (2007) Integrated Risk Information System: Hydrogen cyanide, http://www.epa.gov/ iris ...Environmental Protection Agency (2007) Integrated Risk Information System: Benzene, http://www.epa.gov/ iris /subst/0276.htm 42. United States Environmental...Protection Agency (2007) Integrated Risk Information System: Toluene, http://www.epa.gov/ iris /subst/0118.htm. 43. National Library of Medicine’s TOXNET

When is Information Sufficient for Action Search with Unreliable Yet Informative Intelligence

DTIC Science & Technology

2016-03-30

information: http://pubsonline.informs.org When Is Information Sufficient for Action? Search with Unreliable yet Informative Intelligence Michael Atkinson... Search with Unreliable yet Informative Intelligence. Operations Research Published online in Articles in Advance 30 Mar 2016 . http://dx.doi.org/10.1287...print) � ISSN 1526-5463 (online) http://dx.doi.org/10.1287/opre.2016.1488 © 2016 INFORMS When Is Information Sufficient for Action? Search with

Keeping the Dogs in the Fight: What Combatant Commanders Need to Know about MWDs

DTIC Science & Technology

2013-05-20

Manhattan Project that Bombed,” Public Integrity, Last modified August 2011, http://www.publicintegrity.org/2011/03/27/3799/jieddo- manhattan - project -bombed...Carey, Peter. “JIEDDO: The Manhattan Project that Bombed.” Public Integrity. Last modified August 2011. http://www.publicintegrity.org/2011/03/27...3799/jieddo- manhattan - project -bombed. Community Marines. “MCO 5580.2B.” Last modified August 2008. http://community.marines.mil/news

How to Train a Dragon: How the Peoples Liberation Army Air Force (PLAAF) Modernizes to Fight and Win Wars

DTIC Science & Technology

2015-06-01

Initiative: Definition of Initiative in Oxford Dictionary (American English ) (US),” accessed March 19, 2015, http://www.oxforddictionaries.com/us...definition/american_english/initiative. 10 “Autonomy: Definition of Autonomy in Oxford Dictionary (American English ) (US),” accessed March 19, 2015, http...Definition of Autonomy in Oxford Dictionary (American English ) (US).” Accessed March 19, 2015. http://www.oxforddictionaries.com/us/definition

Pyteomics--a Python framework for exploratory data analysis and rapid software prototyping in proteomics.

PubMed

Goloborodko, Anton A; Levitsky, Lev I; Ivanov, Mark V; Gorshkov, Mikhail V

2013-02-01

Pyteomics is a cross-platform, open-source Python library providing a rich set of tools for MS-based proteomics. It provides modules for reading LC-MS/MS data, search engine output, protein sequence databases, theoretical prediction of retention times, electrochemical properties of polypeptides, mass and m/z calculations, and sequence parsing. Pyteomics is available under Apache license; release versions are available at the Python Package Index http://pypi.python.org/pyteomics, the source code repository at http://hg.theorchromo.ru/pyteomics, documentation at http://packages.python.org/pyteomics. Pyteomics.biolccc documentation is available at http://packages.python.org/pyteomics.biolccc/. Questions on installation and usage can be addressed to pyteomics mailing list: pyteomics@googlegroups.com.

Interactive system for geomagnetic data analysis

NASA Astrophysics Data System (ADS)

Solovev, Igor

2017-10-01

The paper suggests the methods for analyzing geomagnetic field variations, which are implemented in "Aurora" software system for complex analysis of geophysical parameters. The software system allows one to perform a detailed magnetic data analysis. The methods allow one to estimate the intensity of geomagnetic perturbations and to allocate increased geomagnetic activity periods. The software system is publicly available (http://aurorasa.ikir.ru:8580, http://www.ikir.ru:8280/lsaserver/MagneticPage.jsp). This research was supported by the Russian Science Foundation (Project No. 14-11-00194).

Sequanix: a dynamic graphical interface for Snakemake workflows.

PubMed

Desvillechabrol, Dimitri; Legendre, Rachel; Rioualen, Claire; Bouchier, Christiane; van Helden, Jacques; Kennedy, Sean; Cokelaer, Thomas

2018-06-01

We designed a PyQt graphical user interface-Sequanix-aimed at democratizing the use of Snakemake pipelines in the NGS space and beyond. By default, Sequanix includes Sequana NGS pipelines (Snakemake format) (http://sequana.readthedocs.io), and is also capable of loading any external Snakemake pipeline. New users can easily, visually, edit configuration files of expert-validated pipelines and can interactively execute these production-ready workflows. Sequanix will be useful to both Snakemake developers in exposing their pipelines and to a wide audience of users. Source on http://github.com/sequana/sequana, bio-containers on http://bioconda.github.io and Singularity hub (http://singularity-hub.org). dimitri.desvillechabrol@pasteur.fr or thomas.cokelaer@pasteur.fr. Supplementary data are available at Bioinformatics online.

Fitbit Charge HR Wireless Heart Rate Monitor: Validation Study Conducted Under Free-Living Conditions.

PubMed

Gorny, Alexander Wilhelm; Liew, Seaw Jia; Tan, Chuen Seng; Müller-Riemenschneider, Falk

2017-10-20

Many modern smart watches and activity trackers feature an optical sensor that estimates the wearer's heart rate. Recent studies have evaluated the performance of these consumer devices in the laboratory. The objective of our study was to examine the accuracy and sensitivity of a common wrist-worn tracker device in measuring heart rates and detecting 1-min bouts of moderate to vigorous physical activity (MVPA) under free-living conditions. Ten healthy volunteers were recruited from a large university in Singapore to participate in a limited field test, followed by a month of continuous data collection. During the field test, each participant would wear one Fitbit Charge HR activity tracker and one Polar H6 heart rate monitor. Fitbit measures were accessed at 1-min intervals, while Polar readings were available for 10-s intervals. We derived intraclass correlation coefficients (ICCs) for individual participants comparing heart rate estimates. We applied Centers for Disease Control and Prevention heart rate zone cut-offs to ascertain the sensitivity and specificity of Fitbit in identifying 1-min epochs falling into MVPA heart rate zone. We collected paired heart rate data for 2509 1-min epochs in 10 individuals under free-living conditions of 3 to 6 hours. The overall ICC comparing 1-min Fitbit measures with average 10-s Polar H6 measures for the same epoch was .83 (95% CI .63-.91). On average, the Fitbit tracker underestimated heart rate measures by -5.96 bpm (standard error, SE=0.18). At the low intensity heart rate zone, the underestimate was smaller at -4.22 bpm (SE=0.15). This underestimate grew to -16.2 bpm (SE=0.74) in the MVPA heart rate zone. Fitbit devices detected 52.9% (192/363) of MVPA heart rate zone epochs correctly. Positive and negative predictive values were 86.1% (192/223) and 92.52% (2115/2286), respectively. During subsequent 1 month of continuous data collection (270 person-days), only 3.9% of 1-min epochs could be categorized as MVPA according to heart rate zones. This measure was affected by decreasing wear time and adherence over the period of follow-up. Under free-living conditions, Fitbit trackers are affected by significant systematic errors. Improvements in tracker accuracy and sensitivity when measuring MVPA are required before they can be considered for use in the context of exercise prescription to promote better health. ©Alexander Wilhelm Gorny, Seaw Jia Liew, Chuen Seng Tan, Falk Müller-Riemenschneider. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 20.10.2017.

The impact of land-use change from forest to oil palm on soil greenhouse gas and volatile organic compound fluxes in Malaysian Borneo

NASA Astrophysics Data System (ADS)

Drewer, Julia; Leduning, Melissa; Kerdraon-Byrne, Deirdre; Sayer, Emma; Sentien, Justin; Skiba, Ute

2017-04-01

Monocultures of oil palm have expanded in SE Asia, and more recently also in Africa and South America, frequently replacing tropical forests. The limited data available clearly show that this conversion is associated with a potentially large greenhouse gas (GHG) burden. The physical process of land-use change, such is felling, drainage and ploughing can significantly increase emissions of N2O and soil CO2 respiration and decrease CH4 oxidation rates in the short term; and in the long-term regular nitrogen applications will impact in particular soil N2O fluxes. Little is known about volatile organic compound (VOC) fluxes from soil and litter in tropical forests and their speciation or about the links between GHG and VOC fluxes. VOC emissions are important as they directly and indirectly influence the concentrations and lifetimes of air pollutants and GHGs. For example, oxidation of VOCs generate tropospheric ozone which is also a potent GHG. Within ecosystems, monoterpenes can mediate plant-microbe and plant- interactions and protect photosynthesis during abiotic stress. However, little is known about monoterpene composition in the tropics - a widely recognized major global source of terpenoids to the atmosphere. These knowledge gaps make it difficult for developing countries in the tropics, especially SE Asia, to develop effective mitigation strategies. Current understanding of soil GHG fluxes associated with land-use change from forest to oil palm is not sufficient to provide reliable estimates of their carbon footprints and sustainability or advice on GHG mitigation strategies. To provide the necessary data we have installed a total of 56 flux chambers in logged forests, forest fragments and mature and young oil palm plantations as well as riparian zones within the SAFE landscape in SE Sabah (Stability of Altered Forest Ecosystems; http://www.safeproject.net). Soil respiration rates, N2O, CH4 and VOC fluxes together with soil moisture, pH, mineral and total C and N were measured over a two year period. Additionally the effects of changes in forest litter diversity on soil properties were investigated using mesocosms. For this experiment leaf litter was transplanted into different forest types and oil palm plantations of different stand ages to simulate the change in litter-fall caused by changes in above ground plant composition. Laboratory incubations using soil and litter from the field sites provide additional detailed data on soil properties, carbon storage capacity and microbial activity to identify potential mechanisms for the field observations.

Delayed formation of zero-valent selenium nanoparticles by Bacillus mycoides SeITE01 as a consequence of selenite reduction under aerobic conditions

PubMed Central

2014-01-01

Background Selenite (SeO32−) oxyanion shows severe toxicity to biota. Different bacterial strains exist that are capable of reducing SeO32− to non-toxic elemental selenium (Se0), with the formation of Se nanoparticles (SeNPs). These SeNPs might be exploited for technological applications due to their physico-chemical and biological characteristics. The present paper discusses the reduction of selenite to SeNPs by a strain of Bacillus sp., SeITE01, isolated from the rhizosphere of the Se-hyperaccumulator legume Astragalus bisulcatus. Results Use of 16S rRNA and GyrB gene sequence analysis positioned SeITE01 phylogenetically close to B. mycoides. On agarized medium, this strain showed rhizoid growth whilst, in liquid cultures, it was capable of reducing 0.5 and 2.0 mM SeO32− within 12 and 24 hours, respectively. The resultant Se0 aggregated to form nanoparticles and the amount of Se0 measured was equivalent to the amount of selenium originally added as selenite to the growth medium. A delay of more than 24 hours was observed between the depletion of SeO32 and the detection of SeNPs. Nearly spherical-shaped SeNPs were mostly found in the extracellular environment whilst rarely in the cytoplasmic compartment. Size of SeNPs ranged from 50 to 400 nm in diameter, with dimensions greatly influenced by the incubation times. Different SeITE01 protein fractions were assayed for SeO32− reductase capability, revealing that enzymatic activity was mainly associated with the membrane fraction. Reduction of SeO32− was also detected in the supernatant of bacterial cultures upon NADH addition. Conclusions The selenite reducing bacterial strain SeITE01 was attributed to the species Bacillus mycoides on the basis of phenotypic and molecular traits. Under aerobic conditions, the formation of SeNPs were observed both extracellularly or intracellullarly. Possible mechanisms of Se0 precipitation and SeNPs assembly are suggested. SeO32− is proposed to be enzimatically reduced to Se0 through redox reactions by proteins released from bacterial cells. Sulfhydryl groups on peptides excreted outside the cells may also react directly with selenite. Furthermore, membrane reductases and the intracellular synthesis of low molecular weight thiols such as bacillithiols may also play a role in SeO32− reduction. Formation of SeNPs seems to be the result of an Ostwald ripening mechanism. PMID:24606965

Selenium status in adult cats and dogs fed high levels of dietary inorganic and organic selenium.

PubMed

Todd, S E; Thomas, D G; Bosch, G; Hendriks, W H

2012-08-01

Cats (Felis catus) maintain greater blood Se concentrations compared with dogs (Canis familiaris) and, unlike dogs, show no signs of chronic Se toxicity (selenosis) when fed dietary organic Se (selenomethionine) concentrations of 10 μg/g DM. This study investigated the response of cats and dogs to high dietary concentrations of sodium selenite and organic Se to determine differences in metabolism between both species. In 2 consecutive studies, 18 adult cats and 18 adult dogs of with equal numbers of each sex were fed a control diet (0.6 μg Se/g DM) or the control diet supplemented to 8 to 10 μg Se/g DM from Na(2)SeO(3) or organic Se for 3 wk. All animals were fed the control diet 1 mo before the start of the study and blood samples were taken on d 0 and 21. The Se balance was assessed during the final week and a liver biopsy was obtained on the final day of the study. Measurements included plasma Se concentrations, plasma glutathione peroxidise (GPx) activities, plasma Se clearance, Se intake, and urinary Se excretion. No clinical signs of selenosis were observed in the cats or dogs, and apart from Se clearance, form of Se had no effect on any of the measurements. Apparent fecal Se absorption was greater in the dogs fed both forms of Se, while greater plasma Se concentrations were observed in the cats on both the control and supplemented diet (P = 0.034). Cats fed the supplemented diets had lower hepatic Se concentrations (P < 0.001) and excreted more Se in urine (P < 0.001) compared with dogs. Furthermore, cats fed the Na(2)SeO(3) supplement had greater Se clearance rates than dogs (P < 0.001). There was no effect of species on plasma GPx activity. We conclude that cats can tolerate greater dietary Se concentrations as they are more efficient at excreting excess Se in the urine and storing less Se in the liver.

[Effect of nano-selenium on the activities of glutathione peroxidase and type-I deiodinase in the liver of weanling pigs].

PubMed

Zhang, Hongmei; Xia, Meisheng; Hu, Caihong

2007-02-01

To study the effects of nano elemental selenium (Nano-Se) or sodium selenite (Na2SeO3) on the activities of glutathione peroxidase (GSH-Px) and Type-I deiodinase in the liver. A total of 234 weanling pigs (Duroc x Landrace x Yorkshire) at an average initial body weight of 8.3 kg were allocated to 13 treatments. The thirteen dietary treatments were basal diet only (containing 0.04 mg/kg Se), basal diet + 0.1, 0.2, 0.3, 0.4, 0.5, 1.0 mg/kg Se as Na2SeO3 or Nano-Se, respectively. The results were as follows: Supplementation with 1.0 mg/ kg Se as Na2SeO3 reduced (P < 0.05) growth performance and GSH-Px activities as compared with the addition of a concentration range of 0.20-0.40 mg/kg Se. When Nano-Se was added to the diet, the growth and GSH-Px activities remained steady at the peak value as at a concentration of 1.0 mg/kg Se; There were no difference in the activities of GSH-Px between the treatments of Nano-Se and Na2SeO3 when added concentration of Se was 0.10-0.40 mg/kg. The pigs had higher (P < 0.05) activities of GSH-Px at a concentration range of 0.50 and 1.0 mg/kg as Nano-Se than Na2SeO3; Supplentation with Se increased the activity of Type- I deiodinase in liver, however, the increased extent was affected by neither Se sources nor added concentration of Se. The results implicated that for the best concentration range of Weinberg curve, Nano-Se is wider than Na2SeO3.

Bioaccumulation of organic and inorganic selenium in a laboratory food chain

USGS Publications Warehouse

Besser, John M.; Canfield, Timothy J.; La Point, Thomas W.

1993-01-01

Aquatic organisms accumulated selenium (Se) from inorganic and organic Se species via aqueous and food-chain exposure routes. We measured aqueous and food-chain Se bioaccumulation from selenate, selenite, and seleno-L-methionine in a laboratory food chain of algae (Chlamydomonas reinhardtii), daphnids (Daphnia magna), and fish (bluegill, Lepomis macrochirus). Selenium concentrations were monitored radiometrically with 75Se-labeled compounds. All three organisms concentrated Se more strongly from aqueous selenomethionine than from either inorganic Se species. Bioconcentration factors (BCFs) estimated from 1 μg Se/L Se-methionine exposures were approximately 16,000 for algae, 200,000 for daphnids, and 5,000 for bluegills. Algae and daphnids concentrated Se more strongly from selenite (BCFs = 220–3,600) than selenate (BCFs = 65–500) whereas bluegills concenrated Se about equally from both inorganic species (estimated BCFs = 13 to 106). Bioaccumulation of foodborne Se by daphnids and bluegills was similar in food chains dosed with different Se species. Daphnids and bluegills did not accumulate Se concentrations greater than those in their diet, except at very low dietary Se concentrations. Food-chain concentration factors (CFs) for daphnids decreased from near 1.0 to 0.5 with increases in algal Se concentrations, whereas CFs estimated from bluegill exposures averaged 0.5 over a range of foodborne Se concentrations. In exposures based on selenite, bluegills accumulated greater Se concentrations from food than from water. Aqueous and food-chain Se uptakes were approximately additive, and depuration rates were similar in aqueous, food-chain, and combined exposures. Our results suggest that bluegills in Secontaminated habitats accumulate inorganic Se species primarily via food-chain uptake, although organoselenium compounds such as Se-methionine may contribute significantly to Se bioaccumulation by bluegills via both aqueous and food-chain uptake.

Selenium and breast-feeding.

PubMed

Dorea, Jose G

2002-11-01

The objective of the present review is to discuss Se nutrition during breast-feeding, encompassing environmental and maternal constitutional factors affecting breast-milk-Se metabolism and secretion. A literature search of Medline and Webofscience was used to retrieve and select papers dealing with Se and breast milk. Although Se in natural foods occurs only in organic form, breast milk responds to organic and inorganic Se in supplements. Inorganic Se (selenite, selenate), which is largely used in maternal supplements, is not detectable in breast milk. The mammary-gland regulating mechanism controls the synthesis and secretion of seleno-compounds throughout lactation, with a high total Se level in colostrum that decreases as lactation progresses. Se appears in breast milk as a component of specific seleno-proteins and seleno-amino-acids in milk proteins that are well tolerated by breast-fed infants even in high amounts. Se in breast milk occurs as glutathione peroxidase (4-32 % total Se) > selenocystamine > selenocystine > selenomethionine. The wide range of breast-milk Se concentrations depends on Se consumed in natural foods, which reflects the Se content of the soils where they are grown. Se prophylaxis, either through soil Se fertilization or maternal supplements, is effective in raising breast-milk Se concentration. In spite of wide variation, the median Se concentration from studies worldwide are 26, 18, 15, and 17 microg/l in colostrum (0-5 d), transitional milk (6-21 d), mature milk (1-3 months) and late lactation (>5 months) respectively. Se recommendations for infants are presently not achieved in 30 % of the reported breast-milk Se concentrations; nevertheless Se status is greater in breast-fed than in formula-fed infants.

Review: Selenium contamination, fate, and reactive transport in groundwater in relation to human health

NASA Astrophysics Data System (ADS)

Bailey, Ryan T.

2017-06-01

Selenium (Se) is an essential micro-nutrient for humans, but can be toxic at high levels of intake. Se deficiency and Se toxicity are linked with serious diseases, with some regions worldwide experiencing Se deficiency due to Se-poor rocks and soils and other areas dealing with Se toxicity due to the presence of Se-enriched geologic materials. In addition, Se is consumed primarily through plants that take up Se from soil and through animal products that consume these plants. Hence, the soil and groundwater system play important roles in determining the effect of Se on human health. This paper reviews current understanding of Se fate and transport in soil and groundwater systems and its relation to human health, with a focus on alluvial systems, soil systems, and the interface between alluvial systems and Cretaceous shale that release Se via oxidation processes. The review focuses first on the relation between Se and human health, followed by a summary of Se distribution in soil-aquifer systems, with an emphasis on the quantitative relationship between Se content in soil and Se concentration in underlying groundwater. The physical, chemical, and microbial processes that govern Se fate and transport in subsurface systems then are presented, followed by numerical modeling techniques used to simulate these processes in study regions and available remediation strategies for either Se-deficient or Se-toxic regions. This paper can serve as a guide to any field, laboratory or modeling study aimed at assessing Se fate and transport in groundwater systems and its relation to human health.

Selenium hyperaccumulation by Astragalus (Fabaceae) does not inhibit root nodule symbiosis.

PubMed

Alford, Elan R; Pilon-Smits, Elizabeth A H; Fakra, Sirine C; Paschke, Mark W

2012-12-01

A survey of the root-nodule symbiosis in Astragalus and its interaction with selenium (Se) has not been conducted before. Such studies can provide insight into how edaphic conditions modify symbiotic interactions and influence partner coevolution. In this paper plant-organ Se concentration ([Se]) was investigated to assess potential Se exposure to endophytes. • Selenium distribution and molecular speciation of root nodules from Se-hyperaccumulators Astragalus bisulcatus, A. praelongus, and A. racemosus was determined by Se K-edge x-ray absorption spectroscopy. A series of greenhouse experiments were conducted to characterize the response of root-nodule symbiosis in Se-hyperaccumulators and nonhyperaccumulators. • Nodules in three Se-hyperaccumulators (Astragalus crotalariae, A. praelongus, and A. preussii) are reported for the first time. Leaves, flowers, and fruits from Se-hyperaccumulators were routinely above the hyperaccumulator threshold (1,000 µg Se g(-1) DW), but root samples rarely contained that amount, and nodules never exceeded 110 µg Se g(-1) DW. Nodules from A. bisulcatus, A. praelongus, and A. racemosus had Se throughout, with a majority stored in C-Se-C form. Finally, an evaluation of nodulation in Se-hyperaccumulators and nonhyperaccumulators indicated that there was no nodulation inhibition because of plant Se tolerance. Rather, we found that in Se-hyperaccumulators higher levels of Se treatment (up to 100 µM Se) corresponded with higher nodule counts, indicating a potential role for dinitrogen fixation in Se-hyperaccumulation. The effect was not found in nonhyperaccumulators. • As the evolution of Se hyperaccumulation in Astragalus developed, root-nodule symbiosis may have played an integral role.

Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres.

PubMed

Bai, Kaikai; Hong, Bihong; He, Jianlin; Hong, Zhuan; Tan, Ran

2017-01-01

Selenium nanoparticles (SeNPs), as a special form of selenium (Se) supplement, have attracted worldwide attention due to their favorable properties and unique bioactivities. Herein, an eco-friendly and economic way to prepare stable SeNPs is introduced. SeNPs were synthesized in aqueous chitosan (CTS) and then embedded into CTS microspheres by spray-drying, forming selenium nanoparticles-loaded chitosan microspheres (SeNPs-M). The physicochemical properties including morphology, elemental state, size distribution and surface potential were investigated. Institute of Cancer Research mice were used as model animal to evaluate the bioactivities of SeNPs-M. Trigonal-phase SeNPs of ~35 nm were synthesized, and SeNPs-M physically embedding those SeNPs were successfully prepared. Amazingly, acute toxicity test indicated that SeNPs-M were much safer than selenite in terms of Se dose, with a LD 50 of around 18-fold of that of selenite. In addition, SeNPs-M possessed powerful antioxidant activities, as evidenced by a dramatic increase of both Se retention and the levels of glutathione peroxidase, superoxide dismutase and catalase. The design of SeNPs-M can offer a new way for further development of SeNPs with a higher efficacy and better biosafety. Thus, SeNPs-M may be a potential candidate for further evaluation as an Se supplement with antioxidant properties and be used against Se deficiency in animals and human beings.

Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres

PubMed Central

Bai, Kaikai; Hong, Bihong; He, Jianlin; Hong, Zhuan; Tan, Ran

2017-01-01

Selenium nanoparticles (SeNPs), as a special form of selenium (Se) supplement, have attracted worldwide attention due to their favorable properties and unique bioactivities. Herein, an eco-friendly and economic way to prepare stable SeNPs is introduced. SeNPs were synthesized in aqueous chitosan (CTS) and then embedded into CTS microspheres by spray-drying, forming selenium nanoparticles-loaded chitosan microspheres (SeNPs-M). The physicochemical properties including morphology, elemental state, size distribution and surface potential were investigated. Institute of Cancer Research mice were used as model animal to evaluate the bioactivities of SeNPs-M. Trigonal-phase SeNPs of ~35 nm were synthesized, and SeNPs-M physically embedding those SeNPs were successfully prepared. Amazingly, acute toxicity test indicated that SeNPs-M were much safer than selenite in terms of Se dose, with a LD50 of around 18-fold of that of selenite. In addition, SeNPs-M possessed powerful antioxidant activities, as evidenced by a dramatic increase of both Se retention and the levels of glutathione peroxidase, superoxide dismutase and catalase. The design of SeNPs-M can offer a new way for further development of SeNPs with a higher efficacy and better biosafety. Thus, SeNPs-M may be a potential candidate for further evaluation as an Se supplement with antioxidant properties and be used against Se deficiency in animals and human beings. PMID:28684913

Influence of Dietary Selenium Species on Selenoamino Acid Levels in Rainbow Trout.

PubMed

Godin, Simon; Fontagné-Dicharry, Stéphanie; Bueno, Maïté; Tacon, Philippe; Prabhu, Philip Antony Jesu; Kaushik, Sachi; Médale, Françoise; Bouyssiere, Brice

2015-07-22

Two forms of selenium (Se) supplementation of fish feeds were compared in two different basal diets. A 12-week feeding trial was performed with rainbow trout fry using either a plant-based or a fish meal-based diet. Se yeast and selenite were used for Se supplementation. Total Se and Se speciation were determined in both diets and whole body of trout fry using inductively coupled plasma mass spectrometry (ICP MS) and high-performance liquid chromatography (HPLC). The two selenoamino acids, selenomethionine (SeMet) and selenocysteine (SeCys), were determined in whole body of fry after enzymatic digestion using protease type XIV with a prior derivatization step in the case of SeCys. The plant-based basal diet was found to have a much lower total Se than the fish meal-based basal diet with concentrations of 496 and 1222 μg(Se) kg(-1), respectively. Dietary Se yeast had a higher ability to raise whole body Se compared to selenite. SeMet concentration in the fry was increased only in the case of Se yeast supplementation, whereas SeCys levels were similar at the end of the feeding trial for both Se supplemented forms. The results show that the fate of dietary Se in fry is highly dependent on the form brought through supplementation and that a plant-based diet clearly benefits from Se supplementation.

Responses of growing Japanese quails that received selenium from selenium enriched kale sprout (Brassica oleracea var. alboglabra L.).

PubMed

Chantiratikul, Anut; Chinrasri, Orawan; Pakmaruek, Pornpan; Chantiratikul, Piyanete; Thosaikham, Withpol; Aengwanich, Worapol

2011-12-01

The objectives of this study were to determine the effect of selenium (Se) from Se-enriched kale sprout (Brassica oleracea var. alboglabra L.) on the performance and Se concentrations in tissues of growing Japanese quails. Two hundred quails were divided into five treatments. Each treatment consisted of four replicates and each replicate contained ten quails in a completely randomize design. The experiment was conducted for 5 weeks. The treatments were T1, control diet; T2, control diet plus 0.2 mg Se/kg from sodium selenite; T3, T4, and T5, control diet plus 0.2, 0.5, and 1.0 mg Se/kg from Se-enriched kale sprout. The results revealed that Se supplementation had no impact on feed intake, performance, and carcass characteristics of quails (p > 0.05). However, Se supplementation from both sodium selenite and Se-enriched kale sprout increased (p < 0.05) Se concentrations in the heart and breast meat of quails. Se concentrations in the liver and breast meat of quails increased (p < 0.05) with increasing Se concentration from Se-enriched kale sprout. The results indicate that Se from Se-enriched kale sprout offers no advantage over Se from sodium selenite on tissue Se concentration.

Biofortification and phytoremediation of selenium in China

PubMed Central

Wu, Zhilin; Bañuelos, Gary S.; Lin, Zhi-Qing; Liu, Ying; Yuan, Linxi; Yin, Xuebin; Li, Miao

2015-01-01

Selenium (Se) is an essential trace element for humans and animals but at high concentrations, Se becomes toxic to organisms due to Se replacing sulfur in proteins. Selenium biofortification is an agricultural process that increases the accumulation of Se in crops, through plant breeding, genetic engineering, or use of Se fertilizers. Selenium phytoremediation is a green biotechnology to clean up Se-contaminated environments, primarily through phytoextraction and phytovolatilization. By integrating Se phytoremediation and biofortification technologies, Se-enriched plant materials harvested from Se phytoremediation can be used as Se-enriched green manures or other supplementary sources of Se for producing Se-biofortified agricultural products. Earlier studies primarily aimed at enhancing efficacy of phytoremediation and biofortification of Se based on natural variation in progenitor or identification of unique plant species. In this review, we discuss promising approaches to improve biofortification and phytoremediation of Se using knowledge acquired from model crops. We also explored the feasibility of applying biotechnologies such as inoculation of microbial strains for improving the efficiency of biofortification and phytoremediation of Se. The key research and practical challenges that remain in improving biofortification and phytoremediation of Se have been highlighted, and the future development and uses of Se-biofortified agricultural products in China has also been discussed. PMID:25852703

Selenium Cycling Across Soil-Plant-Atmosphere Interfaces: A Critical Review

PubMed Central

Winkel, Lenny H.E.; Vriens, Bas; Jones, Gerrad D.; Schneider, Leila S.; Pilon-Smits, Elizabeth; Bañuelos, Gary S.

2015-01-01

Selenium (Se) is an essential element for humans and animals, which occurs ubiquitously in the environment. It is present in trace amounts in both organic and inorganic forms in marine and freshwater systems, soils, biomass and in the atmosphere. Low Se levels in certain terrestrial environments have resulted in Se deficiency in humans, while elevated Se levels in waters and soils can be toxic and result in the death of aquatic wildlife and other animals. Human dietary Se intake is largely governed by Se concentrations in plants, which are controlled by root uptake of Se as a function of soil Se concentrations, speciation and bioavailability. In addition, plants and microorganisms can biomethylate Se, which can result in a loss of Se to the atmosphere. The mobilization of Se across soil-plant-atmosphere interfaces is thus of crucial importance for human Se status. This review gives an overview of current knowledge on Se cycling with a specific focus on soil-plant-atmosphere interfaces. Sources, speciation and mobility of Se in soils and plants will be discussed as well as Se hyperaccumulation by plants, biofortification and biomethylation. Future research on Se cycling in the environment is essential to minimize the adverse health effects associated with unsafe environmental Se levels. PMID:26035246

Selenium cycling across soil-plant-atmosphere interfaces: a critical review.

PubMed

Winkel, Lenny H E; Vriens, Bas; Jones, Gerrad D; Schneider, Leila S; Pilon-Smits, Elizabeth; Bañuelos, Gary S

2015-05-29

Selenium (Se) is an essential element for humans and animals, which occurs ubiquitously in the environment. It is present in trace amounts in both organic and inorganic forms in marine and freshwater systems, soils, biomass and in the atmosphere. Low Se levels in certain terrestrial environments have resulted in Se deficiency in humans, while elevated Se levels in waters and soils can be toxic and result in the death of aquatic wildlife and other animals. Human dietary Se intake is largely governed by Se concentrations in plants, which are controlled by root uptake of Se as a function of soil Se concentrations, speciation and bioavailability. In addition, plants and microorganisms can biomethylate Se, which can result in a loss of Se to the atmosphere. The mobilization of Se across soil-plant-atmosphere interfaces is thus of crucial importance for human Se status. This review gives an overview of current knowledge on Se cycling with a specific focus on soil-plant-atmosphere interfaces. Sources, speciation and mobility of Se in soils and plants will be discussed as well as Se hyperaccumulation by plants, biofortification and biomethylation. Future research on Se cycling in the environment is essential to minimize the adverse health effects associated with unsafe environmental Se levels.